Ichiro Kusumiresearchmap個人ページ

Last Updated : 2018/07/03

Basic Information

Profile

Affiliation
Faculty of Medicine Neurological Disorder
Center for Experimental Research in Social Sciences
Research and Education Center for Brain Science
Hokkaido University Hospital
Job TitleProfessor 
Degree
M.D., Ph.D.
E-mailikusumimed.hokudai.ac.jp
URL
Research funding number30250426
  • My major was psychopharmacology and the main research theme were the pathophysiology of mood disorders and mechanisms of action of psychotropic drugs. I have recently been interested in the neuroimaging and psychophysiology of schizophrenia.

Research Keywords

schizophrenia, dopamine D2 receptor, molecular genetics, psychopharmacology, Calcium, SSRI, atypical antipsychotics, serotonin 5-HT2A receptor, platelet, protein kinase C, bipolar disorder, serotonin, lithium, valproate

Research Areas

Clinical internal medicine / Psychiatric science
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Clinical internal medicine / Psychiatric science

Academic Societies

THE JAPANESE SOCIETY OF NEUROPSYCHOPHARMACOLOGY
JAPANESE SOCIETY MOOD DISORDERS
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THE JAPANESE SOCIETY OF NEUROPSYCHOPHARMACOLOGY
JAPANESE SOCIETY MOOD DISORDERS

Research Activities

Papers

Transethnic replication study to assess the association between clozapine-induced agranulocytosis/granulocytopenia and genes at 12p12.2 in a Japanese population.
Saito T, Ikeda M, Hashimoto R, Iwata N; Members of the Clozapine Pharmacogenomics Consortium of Japan are the following, Yamamori H, Yasuda Y, Fujimoto M, Kondo K, Shimasaki A, Kawase K, Miyata M, Mushiroda T, Ozeki T, Kubo M, Fujita K, Kida N, Nakai M, Otsuru T, Fukuji Y, Murakami M, Mizuno K, Shiratsuchi T, Numata S, Ohmori T, Ueno SI, Yada Y, Tanaka S, Kishi Y, Takaki M, Mamoto A, Taniguchi N, Sawa Y, Watanabe H, Noda T, Amano Y, Kimura T, Fukao T, Suwa T, Murai T, Kubota M, Ueda K, Tabuse H, Kanahara N, Kawai N, Nemoto K, Makinodan M, Nishihata Y, Hashimoto N, Kusumi I, Fujii Y, Miyata R, Hirakawa K, Ozaki N
Biol Psychiatry 82(1) e9-e10 2017
Verbal memory impairments in bipolar disorder: Effect of type of word learning tasks.
Sumiyoshi T, Toyomaki A, Kawano N, Kitajima T, Kusumi I, Ozaki N, Iwata N, Sueyoshi K, Nakagome K
Psychiatry Clin Neurosci 71(8) 570-571 2017
Transient lesions of the splenium of the corpus callosum following rapid withdrawal of levetiracetam.
Sawagashira R, Narita H, Hashimoto N, Kurita T, Nakagawa S, SaithT, Kusumi I
Epileptic Disord 19(3) 379-382 2017
The mediator effect of personality traits on the relationship between childhood abuse and depressive symptoms in schizophrenia.
Okubo R, Inoue T, Hashimoto N, Suzukawa A, Tanabe H, Oka M, Narita H, Ito K, Kako Y, Kusumi I
Psychiatry Res 257 126-131 2017
Verbal memory impairment in patients with subsyndromal bipolar disorder.
Sumiyoshi T, Toyomaki A, Kawano N, Kitajima T, Kusumi I, Ozaki N, Iwata N, Sueyoshi K, Nakagome K
Front Psychiatry 8 168 2017
Mediators of the effects of rice intake on health in individuals consuming a traditional Japanese diet centered on rice.
Koga M, Toyomaki A, Miyazaki A, Nakai Y, Yamaguchi A, Kubo C, Suzuki J, Ohkubo I, Shimizu M, Musashi M, Kiso Y, Kusumi I
PLoS One 12(10) e0185816 2017
Interpersonal sensitivity mediates the effects of child abuse and affective temperaments on depressive symptoms in the general adult population.
Otsuka A, Takaesu Y, Sato M, Masuya J, Ichiki M, Kusumi I, Inoue T
Neuropsychiatr Dis Treat 13 2559-2568 2017
The relationship between a low grain intake dietary pattern and impulsive behaviors in middle-aged Japanese people.
Toyomaki A, Koga M, Okada E, Nakai Y, Miyazaki A, Tamakoshi A, Kiso Y, Kusumi I
PLoS ONE 12(7) e0181057 2017
Neural responses to feedback information produced by self-generated or other-generated decision-making and their impairment in schizophrenia.
Toyomaki A, Hashimoto N, Kako Y, Murohashi H, Kusumi I
PLoS One 12(8) e0183792 2017
Cognitive insight and functional outcome in schizophrenia: a multi-center collaborative study with the specific level of functioning scale-Japanese version.
Sumiyoshi T, Nishida K, Niimura H, Toyomaki A, Morimoto T, Tani M, Inada K, Ninomiya T, Hori H, Manabe J, Katsuki A, Kubo T, Koshikawa Y, Shirahama M, Kohno K, Kinoshita T, Kusumi I, Iwanami A, Ueno T, Kishimoto T, Terao T, Nakagome K
Schizophr Res Cogn 6 9-14 2017
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Transethnic replication study to assess the association between clozapine-induced agranulocytosis/granulocytopenia and genes at 12p12.2 in a Japanese population.
Saito T, Ikeda M, Hashimoto R, Iwata N; Members of the Clozapine Pharmacogenomics Consortium of Japan are the following, Yamamori H, Yasuda Y, Fujimoto M, Kondo K, Shimasaki A, Kawase K, Miyata M, Mushiroda T, Ozeki T, Kubo M, Fujita K, Kida N, Nakai M, Otsuru T, Fukuji Y, Murakami M, Mizuno K, Shiratsuchi T, Numata S, Ohmori T, Ueno SI, Yada Y, Tanaka S, Kishi Y, Takaki M, Mamoto A, Taniguchi N, Sawa Y, Watanabe H, Noda T, Amano Y, Kimura T, Fukao T, Suwa T, Murai T, Kubota M, Ueda K, Tabuse H, Kanahara N, Kawai N, Nemoto K, Makinodan M, Nishihata Y, Hashimoto N, Kusumi I, Fujii Y, Miyata R, Hirakawa K, Ozaki N
Biol Psychiatry 82(1) e9-e10 2017
Verbal memory impairments in bipolar disorder: Effect of type of word learning tasks.
Sumiyoshi T, Toyomaki A, Kawano N, Kitajima T, Kusumi I, Ozaki N, Iwata N, Sueyoshi K, Nakagome K
Psychiatry Clin Neurosci 71(8) 570-571 2017
Transient lesions of the splenium of the corpus callosum following rapid withdrawal of levetiracetam.
Sawagashira R, Narita H, Hashimoto N, Kurita T, Nakagawa S, SaithT, Kusumi I
Epileptic Disord 19(3) 379-382 2017
The mediator effect of personality traits on the relationship between childhood abuse and depressive symptoms in schizophrenia.
Okubo R, Inoue T, Hashimoto N, Suzukawa A, Tanabe H, Oka M, Narita H, Ito K, Kako Y, Kusumi I
Psychiatry Res 257 126-131 2017
Verbal memory impairment in patients with subsyndromal bipolar disorder.
Sumiyoshi T, Toyomaki A, Kawano N, Kitajima T, Kusumi I, Ozaki N, Iwata N, Sueyoshi K, Nakagome K
Front Psychiatry 8 168 2017
Mediators of the effects of rice intake on health in individuals consuming a traditional Japanese diet centered on rice.
Koga M, Toyomaki A, Miyazaki A, Nakai Y, Yamaguchi A, Kubo C, Suzuki J, Ohkubo I, Shimizu M, Musashi M, Kiso Y, Kusumi I
PLoS One 12(10) e0185816 2017
Interpersonal sensitivity mediates the effects of child abuse and affective temperaments on depressive symptoms in the general adult population.
Otsuka A, Takaesu Y, Sato M, Masuya J, Ichiki M, Kusumi I, Inoue T
Neuropsychiatr Dis Treat 13 2559-2568 2017
The relationship between a low grain intake dietary pattern and impulsive behaviors in middle-aged Japanese people.
Toyomaki A, Koga M, Okada E, Nakai Y, Miyazaki A, Tamakoshi A, Kiso Y, Kusumi I
PLoS ONE 12(7) e0181057 2017
Neural responses to feedback information produced by self-generated or other-generated decision-making and their impairment in schizophrenia.
Toyomaki A, Hashimoto N, Kako Y, Murohashi H, Kusumi I
PLoS One 12(8) e0183792 2017
Cognitive insight and functional outcome in schizophrenia: a multi-center collaborative study with the specific level of functioning scale-Japanese version.
Sumiyoshi T, Nishida K, Niimura H, Toyomaki A, Morimoto T, Tani M, Inada K, Ninomiya T, Hori H, Manabe J, Katsuki A, Kubo T, Koshikawa Y, Shirahama M, Kohno K, Kinoshita T, Kusumi I, Iwanami A, Ueno T, Kishimoto T, Terao T, Nakagome K
Schizophr Res Cogn 6 9-14 2017
Association between suicide-related ideations and affective temperaments in the Japanese general adult population.
Mitsui N, Nakai Y, Inoue T, Udo N, Kitagawa K, Wakatsuki Y, Kameyama R, Toyomaki A, Ito YM, Kitaichi Y, Nakagawa S, Kusumi I
PLoS One 12(6) e0179952 2017
The influence of parental care and overprotection, neuroticism and adult stressful life events on depressive symptoms in the general adult population.
Ono Y, Takaesu Y, Nakai Y, Ichiki M, Masuya J, Kusumi I, Inoue T
J Affect Disord 217 66-72 2017
Reliability and validity of the California Verbal Learning Test-II - Japanese version.
Sumiyoshi T, Toyomaki A, Kawano N, Kitajima T, Kusumi I, Ozaki N, Iwata N, Nakagome K
Psychiatry Clin Neurosci 71(6) 47-48 2017
Clinical pharmacokinetic interactions between lamotorigine and hormonal contraceptives in bipolar I disorders.
Sawagashira R, Fujii Y, Kusumi I
Psychiatry Clin Neurosci 71(4) 290 2017
Enrichment of deleterious variants of mitochondrial DNA polymerase gene POLG1 in bipolar disorder.
Kasahara T, Ishiwata M, Kakiuchi C, Fuke S, Iwata N, Ozaki N, Kunugi H, Minabe Y, Nakamura K, Iwata Y, Fujii K, Kanba S, Ujike H, Kusumi I, Kataoka M, Matoba N, Takata A, Iwamoto K, Yoshikawa T, Kato T
Psychiat Clin Neurosci 71(8) 518-529 2017
Validity and reliability of the Cognitive Complaints in Bipolar Disorder Rating Assessment (COBRA) in Japanese patients with bipolar disorder.
Toyoshima K, Fujii Y, Mitsui N, Kako Y, Asakura S, Martinez-Aran A, Vieta E, Kusumi I
Psychiatry Res 254 85-89 2017
Associations among depressive symptoms, childhood abuse, neuroticism, and adult stressful life events in the general adult population.
Ono K, Takaesu Y, Nakai Y, Shimura A, Ono Y, Murakoshi A, Matsumoto Y, Tanabe H, Kusumi I, Inoue T
Neuropsychiatr Dis Treat 13 477-482 2017
The exercise-glucocorticoid paradox: how exercise is beneficial to cognition, mood, and the brain while increasing glucocorticoid levels.
Chen C, Nakagawa S, An Y, Ito K, Kitaichi Y, Kusumi I
Front Neuroendocrinology 44 83-102 2017
Childhood parental bonding affects adulthood trait anxiety trough self-esteem.
Shimura A, Takaesu Y, Nakai Y. Murakoshi A, Ono Y, Matsumoto Y, Kusumi I, Inoue T
Compr Psychiatry 74 15-20 2017
Post-steroid neuropsychiatric manifestations are significantly more frequent in SLE compared with other systemic autoimmune diseases and predict better prognosis compared with de novo neuropsychiatric SLE.
Shimizu Y, Yasuda S, Kako Y, Nakagawa S, Kanda M, Hisada R, Ohmura K, Shimamura S, Shida H, Fujieda Y, Kato M, Oku K, Bohgaki T, Horita T, Kusumi I, Atsumi T
Autoimmun Rev 15 786-794 2016
Very Long-Term Outcome of Non-Surgically Treated Patients with Temporal Lobe Epilepsy with Hippocampal Sclerosis: A Retrospective Study.
Kurita T, Sakurai K, Takeda Y, Horinouchi T, Kusumi I
PLoS One 14;11(7) e0159464 2016
Loss of function mutations in ATP2A2 and psychoses: A case report and literature survey.
Nakamura T, Kazuno A, Nakajima K, Kusumi I, Tsuboi T, Kato T
Psychiat Clin Neurosci 70 342-350 2016
Mean kurtosis alterations of cerebral white matter in patients with schizophrenia revealed by diffusion kurtosis imaging.
Narita H, Tha KK, Hashimoto N, Hamaguchi H, Nakagawa S, Shirato H, Kusumi I
Prog Neuropsychopharmacol Biol Psychiatry 71 169-175 2016
Confirmation of the factorial structure of the Japanese short version of the TEMPS-A in psychiatric patients and general adults.
Nakato Y, Inoue T, Nakagawa S, Kitaichi Y, Kameyama R, Wakatsuki Y, Kitagawa K, Omiya Y, Kusumi I
Neuropsychiatr Dis Treat 12 2173-2179 2016
Mirtazapine exerts an anxiolytic-like effect through activation of the median raphe nucleus-dorsal hippocampal 5-HT pathway in contextual fear conditioning in rats.
An Y, Chen C, Inoue T, Nakagawa S, Kitaichi Y, Wang C, Izumi T, Kusumi I
Prog Neuropsychopharmacol Biol Psychiatry 70 17-23 2016
Combined treatment with subchronic lithium and acute intracerebral mirtazapine microinjection into the median raphe nucleus exerted an anxiolytic-like effect synergistically.
An Y, Inoue T, Kitaichi Y, Chen C, Nakagawa S, Wang C, Kusumi I
Eur J Pharmacol 783 112-116 2016
The influence of childhood abuse, adult life events, and affective temperaments on the well-being of the general, nonclinical adult population.
Kanai Y, Takaesu Y, Nakai Y, Ichiki M, Sato M, Matsumoto Y, Ishikawa J, Ono Y, Murakoshi A, Tanabe H, Kusumi I, Inoue T
Neuropsychiatr Dis Treat 12 823-832 2016
The role of medial prefrontal corticosterone and dopamine in the antidepressant-like effect of exercise.
Chen C, Nakagawa S, Kitaichi Y, An Y, Omiya Y, Song N, Koga M, Kato A, Inoue T, Kusumi I
Psychoneuroendocrinology 69 1-9 2016
Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study.
Hou L, Heilbronner U, Degenhardt F, Adli M, Akiyama K, Akula N, Ardau R, Arias B, Backlund L, Banzato CE, Benabarre A, Bengesser S, Bhattacharjee AK, Biernacka JM, Birner A, Brichant-Petitjean C, Bui ET, Cervantes P, Chen GB, Chen HC, Chillotti C, Cichon S, Clark SR, Colom F, Cousins DA, Cruceanu C, Czerski PM, Dantas CR, Dayer A, Étain B, Falkai P, Forstner AJ, Frisén L, Fullerton JM, Gard S, Garnham JS, Goes FS, Grof P, Gruber O, Hashimoto R, Hauser J, Herms S, Hoffmann P, Hofmann A, Jamain S, Jiménez E, Kahn JP, Kassem L, Kittel-Schneider S, Kliwicki S, König B, Kusumi I, Lackner N, Laje G, Landén M, Lavebratt C, Leboyer M, Leckband SG, Jaramillo CA, MacQueen G, Manchia M, Martinsson L, Mattheisen M, McCarthy MJ, McElroy SL, Mitjans M, Mondimore FM, Monteleone P, Nievergelt CM, Nöthen MM, Ösby U, Ozaki N, Perlis RH, Pfennig A, Reich-Erkelenz D, Rouleau GA, Schofield PR, Schubert KO, Schweizer BW, Seemüller F, Severino G, Shekhtman T, Shilling PD, Shimoda K, Simhandl C, Slaney CM, Smoller JW, Squassina A, Stamm T, Stopkova P, Tighe SK, Tortorella A, Turecki G, Volkert J, Witt S, Wright A, Young LT, Zandi PP, Potash JB, DePaulo JR, Bauer M, Reininghaus EZ, Novák T, Aubry JM, Maj M, Baune BT, Mitchell PB, Vieta E, Frye MA, Rybakowski JK, Kuo PH, Kato T, Grigoroiu-Serbanescu M, Reif A, Del Zompo M, Bellivier F, Schalling M, Wray NR, Kelsoe JR, Alda M, Rietschel M, McMahon FJ, Schulze TG
Lancet 387 1085-1093 2016
The effectiveness of suicide prevention gatekeeper-training for university administrative staff in Japan.
Hashimoto N, Suzuki Y, Kato TA, Fujisawa D, Sato R, Aoyama-Uehara K, Fukasawa M, Asakura S, Kusumi I, Otsuka K
Psychiatry Clin Neurosci 70 62-70 2016
Affective temperaments play an important role in the relationship between childhood abuse and depressive symptoms in major depressive disorder.
Toda H, Inoue T, Tsunoda T, Nakai Y, Tanichi M, Tanaka T, Hashimoto N, Takaesu Y, Nakagawa S, Kitaichi Y, Boku S, Tanabe H, Nibuya M, Yoshino A, Kusumi I
Psychiatr Res 236 142-147 2016
Different P50 sensory gating measures reflect different cognitive dysfunction in schizophrenia.
Toyomaki A, Hashimoto N, Kako Y, Tomimatsu Y, Koyama T, Kusumi I
Schizophr Res Cogn 3 166-169 2015
The moderate effects of affective temperaments, childhood abuse and adult stressful life events on depressive symptoms in the nonclinical general adult population.
Nakai Y, Inoue T, Chen C, Toda H, Toyomaki A, Nakato Y, Nakagawa S, Kitaichi Y, Kameyama R, Wakatsuki Y, Kitagawa K, Tanabe H, Kusumi I
J Affect Disord 187 203-210 2015
The structural equation analysis of childhood abuse, adult stressful life events, and temperaments in major depressive disorders and their influence on refractoriness.
Toda H, Inoue T, Tsunoda T, Nakai Y, Tanichi M, Tanaka T, Hashimoto N, Nakato Y, Nakagawa S, Kitaichi Y, Mitsui N, Boku S, Tanabe H, Nibuya M, Yoshino A, Kusumi I
Neuropsychiatr Dis Treat 14 2079-2090 2015
Reinforcement learning in depression: A review of computational research.
Chen C, Takahashi T, Nakagawa S, Inoue T, Kusumi I
Neurosci Biobehav Rev 12(55) 247-267 2015
Psychopharmacology of atypical antipsychotic drugs: From the receptor binding profile to neuroprotection and neurogenesis.
Kusumi I, Boku S, Takahashi Y
Psychiatry Clin Neurosci 69 243-258 2015
Involvement of Serotonin Transporter Gene Polymorphisms (5-HTT) in Impulsive Behavior in the Japanese Population.
Nomura M, Kaneko M, Okuma Y, Nomura J, Kusumi I, Koyama T, Nomura Y
PLoS One 16(10(3)) e0119743 2015
VGluT3-Expressing CCK-Positive Basket Cells Construct Invaginating Synapses Enriched with Endocannabinoid Signaling Proteins in Particular Cortical and Cortex-Like Amygdaloid Regions of Mouse Brains.
Omiya Y, Uchigashima M, Konno K, Yamasaki M, Miyazaki T, Yoshida T, Kusumi I, Watanabe M
J Neurosci 35 4215-4228 2015
Chronic Ischemia Alters Brain Microstructural Integrity and Cognitive Performance in Adult Moyamoya Disease.
Kazumata K, Khin Tha K, Narita H, Kusumi I, Shichinohe H, Ito M, Nakayama N, Houkin K
Stroke 46 354-360 2015
Subchronic lithium treatment increases the anxiolytic-like effect of mirtazapine on the expression of contextual conditioned fear.
An Y, Inoue T, Kitaichi Y, Nakagawa S, Wang C, Chen C, Song N, Kusumi I
Eur J Pharmacol 747 13-17 2015
Neonatal Maternal Separation Alters the Capacity of Adult Neural Precursor Cells to Differentiate into Neurons Via Methylation of Retinoic Acid Receptor Gene Promoter.
Boku S, Toda H, Nakagawa S, Kato A, Inoue T, Koyama T, Hiroi N, Kusumi I
Biol Psychiatry 77 335-344 2015
Long-term efficacy and tolerability of quetiapine in patients with schizophrenia who switched from other antipsychotics because of inadequate therapeutic response: a prospective open-label study.
Hashimoto N, Toyomaki A, Honda M, Miyano S, Nitta N, Sawayama H, Sugawara Y, Uemura K, Tsukamoto N, Koyama T, Kusumi I
Ann Gen Psychiatry 14 1 2015
Simple pulmonary eosinophilia associated with clozapine treatment.
Hashimoto N, Maeda T, Okubo R, Narita H, Kusumi I
J Clin Psychopharmacol. 35 99-101 2015
Does temperature or sunshine mediate the effect of latitude on affective temperaments? A study of 5 regions in Japan.
Inoue T, Kohno K, Baba H, Takeshima M, Honma H, Nakai Y, Suzuki T, Hatano K, Arai H, Matsubara S, Kusumi I, Terao T
J Affect Disord 172C 141-145 2015
Variant GADL1 and response to lithium in bipolar I disorder
The consortium on lithium genetics
N Engl J Med 370(19) 1857-1859 2014
The potential of SLC6A4 gene methylation analysis for the diagnosis and treatment of major depression
Okada S, Morinobu S, Fuchikami M, Segawa M, Yokomaku K, Kataoka T, Okamoto Y, Yamawaki S, Inoue T, Kusumi I, Koyama T, Tsuchiyama K, Terao T, Mimura M
J Psychiatr Res 53(1) 47-53 2014
The influence of childhood abuse, adult stressful life events and temperaments on depressive symptoms in the non-clinical general adult population
Nakai Y, Inoue T, Toda H, Toyomaki A, Nakato Y, Nakagawa S, Kitaichi Y, Kameyama R, Hayashishita Y, Wakatsuki Y, Oba K, Tanabe H, Kusumi I
J Affect Disord 158 101-107 2014
Video event data recording of a taxi driver used for diagnosis of epilepsy
Sakurai K, Yamamoto J, Kurita T, Takeda Y, Kusumi I
Epilepsy Behav Case Rep 2(1) 24-25 2014
Effect of coadministration of citalopram with mirtazapine or atipamezole on rat contextual conditioned fear
Masuda T, Inoue T, An Y, Takamura N, Nakagawa S, Kitaichi Y, Koyama T, Kusumi I
Neuropsychiatr Dis Treat 10 289-295 2014
The effect of dopamine on adult hippocampal neurogenesis
Takamura N, Nakagawa S, Masuda T, Boku S, Kato A, Song N, An Y, Kitaichi Y, Inoue T, Koyama T, Kusumi I
Prog Neuropsychopharmacol Biol Psychiatry 50 116-124 2014
Valproate recovers the inhibitory effect of dexamethasone on the proliferation of the adult dentate gyrus-derived neural precursor cells via GSK-3β and β-catenin pathway
Boku S, Nakagawa S, Masuda T, Nishikawa H, Kato A, Takamura N, Omiya Y, Kitaichi Y, Inoue T, Kusumi I
Eur J Pharmacol 723(1) 425-430 2014
Akinetopsia as epileptic seizure
Sakurai K, Kurita T, Takeda Y, Kusumi I
Epilepsy Behav Case Rep 1(1) 74-76 2013
Selegiline remarkably improved stage 5 treatment-resistant major depressive disorder: a case report
Kitaichi Y, Inoue T, Mitsui N, Nakagawa S, Kameyama R, Hayashishita Y, Shiga T, Kusumi I, Koyama T
Neuropsychiatric Disease and Treatment 9 1591-1594 2013
Neurocognitive impairments and quality of life in unemployed patients with remitted major depressive disorder
Shimizu Y, Kitagawa N, Mitsui N, Fujii Y, Toyomaki A, Hashimoto N, Kako Y, Tanaka T, Asakura S, Kusumi I
Psychiatry Res 210(3) 913-918 2013
Pilomotor seizures in temporal lobe epilepsy: A case report with sequential changes in magnetic resonance imaging
Kurita T, Sakurai K, Takeda Y, Kusumi I
Epilepsy Behav Case Rep 1(1) 142-145 2013
Anxiolytic-like effect of mirtazapine mediates its effect in the median raphe nucleus
An Y, Inoue T, Kitaichi Y, Izumi T, Nakagawa S, Song N, Chen C, Li X-B, Koyama T, Kusumi I
Eur J Pharmacol 720(1-3) 192-197 2013
Tricyclic antidepressant amitriptyline indirectly Increases the Proliferation of Adult Dentate Gyrus- Derived Neural Precursors: An Involvement of Astrocytes
Boku S, Nakashima KH, Nakagawa S, Kato A, Kajitani N, Inoue T, Kusumi I, Takebayashi M
Plos One 8(11) 2013
Temperament and character profiles of Japanese university students with depressive episodes and ideas of suicide or self-harm: A PHQ-9 screening study
Mitsui N, Asakura S, Shimizu Y, Fujii Y, Kako Y, Tanaka T, Oba K, Inoue T, Kusumi I
Compr Psychiatry 54(8) 1215-1221 2013
Assessment of Response to Lithium Maintenance Treatment in Bipolar Disorder: A Consortium on Lithium Genetics (ConLiGen) Report
Manchia M, Adli M, Akula N, Ardau R, Aubry JM, Backlund L, Banzato CE, Baune BT, Bellivier F, Bengesser S, Biernacka JM, Brichant-Petitjean C, Bui E, Calkin CV, Cheng AT, Chillotti C, Cichon S, Clark S, Czerski PM, Dantas C, Zompo MD, Depaulo JR, Detera-Wadleigh SD, Etain B, Falkai P, Frisén L, Frye MA, Fullerton J, Gard S, Garnham J, Goes FS, Grof P, Gruber O, Hashimoto R, Hauser J, Heilbronner U, Hoban R, Hou L, Jamain S, Kahn JP, Kassem L, Kato T, Kelsoe JR, Kittel-Schneider S, Kliwicki S, Kuo PH, Kusumi I, Laje G, Lavebratt C, Leboyer M, Leckband SG, López Jaramillo CA, Maj M, Malafosse A, Martinsson L, Masui T, Mitchell PB, Mondimore F, Monteleone P, Nallet A, Neuner M, Novák T, O'Donovan C, Osby U, Ozaki N, Perlis RH, Pfennig A, Potash JB, Reich-Erkelenz D, Reif A, Reininghaus E, Richardson S, Rouleau GA, Rybakowski JK, Schalling M, Schofield PR, Schubert OK, Schweizer B, Seemüller F, Grigoroiu-Serbanescu M, Severino G, Seymour LR, Slaney C, Smoller JW, Squassina A, Stamm T, Steele J, Stopkova P, Tighe SK, Tortorella A, Turecki G, Wray NR, Wright A, Zandi PP, Zilles D, Bauer M, Rietschel M, McMahon FJ, Schulze TG, Alda M
PLoS One 8(6) 2013
Severity of generalized social anxiety disorder correlates with low executive functioning
Fujii Y, Kitagawa N, Shimizu Y, Mitsui N, Toyomaki A, Hashimoto N, Kako Y, Tanaka T, Asakura S, Koyama T, Kusumi I
Neurosci Lett 543 42-46 2013
Development and validation of ascreening questionnaire for present or past(hypo)manic episodes based on DSM-IV-TR criteria
Kameyama R, Inoue T, Uchida M, Tanaka T, Kitaichi U, Nakato Y, Hayashishita Y, Nakai Y, Nakagawa S, Kusumi I, Koyama T
J Affect Disord 150(2) 546-550 2013
GDNF facilitates differentiation of the adult dentate gyrus-derived neural precursor cells into astrocytes via STAT3
Boku S, Nakagawa S, Takamura N, Kato A, Takebayashi M, Hisaoka-Nakashima K, Omiya Y, Inoue T, Kusumi I
Biochem Biophys Res Commun. 434(4) 779-784 2013
Differences between bipolar and unipolar depression on Rorschach testing
Kimura H, Osaki A, Kawashima R, Inoue T, Nakagawa S, Suzuki K, Asakura S, Tanaka T, Kitaichi Y, Masui T, Kitagawa N, Kako Y, Abekawa T, Kusumi I, Yamanaka H, Denda K, Koyama T
Neuropsychiatr Dis Treat 9 619-627 2013
Temperament and character profiles of Japanese university student suicide completers
Mitsui N, Asakura S, Inoue T, Shimizu Y, Fujii Y, Kako Y, Tanaka T, Kitagawa N, Kusumi I
Compr Psychiatry 54(5) 556-561 2013
Brain Science (104) The cognitive function of patients with social anxiety disorder
21(4) 444-447 2012/10
Discrepancy of neural response between exogenous and endogenous task switching: an event-related potentials study.
Miyajima M, Toyomaki A, Hashimoto N, Kusumi I, Murohashi H, Koyama T
Neuroreport 23(11) 642-646 2012/08
Tardive laryngeal dystonia associated with aripiprazole monotherapy.
Matsuda N, Hashimoto N, Kusumi I, Ito K, Koyama T
Journal of clinical psychopharmacology 32(2) 297-298 2012/04
Effect of olanzapine orally disintegrating tablet versus oral standard tablet on body weight in patients with schizophrenia: a randomized open-label trial.
Kusumi I, Honda M, Uemura K, Sugawara Y, Kohsaka M, Tochigi A, Koyama T
Progress in neuro-psychopharmacology & biological psychiatry 36(2) 313-317 2012/03
Delays in psychiatric drug development in Japan
Shimazawa R, Kusumi I, Ikeda M
J. Clin. Pharm. Ther. 37(3) 348-351 2012
Social Anxiety/Taijin-Kyofu Scale (SATS): development and psychometric evaluation of a new instrument.
Asakura S, Inoue T, Kitagawa N, Hasegawa M, Fujii Y, Kako Y, Nakato Y, Hashimoto N, Ito K, Tanaka T, Nakagawa S, Kusumi I, Koyama T
Psychopathology 45(2) 96-101 2012
Effect of triiodothyronine (T(3)) augmentation of acute milnacipran administration on monoamine levels: an in vivo microdialysis study in rats.
Kitaichi Y, Inoue T, Nakagawa S, Boku S, Kato A, Kusumi I, Koyama T
Neuropsychiatric disease and treatment 8 501-507 2012
Screening for diabetes using monitoring guidance in schizophrenia patients treated with second-generation antipsychotics: a 1-year follow-up study.
Kusumi I, Ito K, Uemura K, Honda M, Hayashishita T, Miyamoto K, Sawayama H, Kako Y, Tsuchida S, Hashimoto N, Koyama T
Progress in neuro-psychopharmacology & biological psychiatry 35(8) 1922-1926 2011/12
Depressive patients are more impulsive and inconsistent in intertemporal choice behavior for monetary gain and loss than healthy subjects- an analysis based on Tsallis' statistics
Taiki Takahashi, Hidemi Oono, Takeshi Inoue, Shuken Boku, Yuki Kako, Yuji Kitaichi, Ichiro Kusumi, Takuya Masui, Shin Nakagawa, Katsuji Suzuki, Teruaki Tanaka, Tsukasa Koyama, Mark H. B. Radford
Neuro Endocrinol Lett. 2008, 29(3):351-358 2011/11
Screening for diabetes using Japanese monitoring guidance in schizophrenia patients treated with second-generation antipsychotics: a cross-sectional study using baseline data.
Kusumi I, Ito K, Honda M, Hayashishita T, Uemura K, Hashimoto N, Murasaki M, Atsumi Y, Kadowaki T, Koyama T
Psychiatry and clinical neurosciences 65(4) 349-355 2011/06
New generation antipsychotics and metabolic abnormalities
Journal of Japanese Association of Psychiatric Hospitals 30(3) 201-205 2011/03
DNA methylation profiles of the brain-derived neurotrophic factor (BDNF) gene as a potent diagnostic biomarker in major depression.
Fuchikami M, Morinobu S, Segawa M, Okamoto Y, Yamawaki S, Ozaki N, Inoue T, Kusumi I, Koyama T, Tsuchiyama K, Terao T
PloS one 6(8) 2011

Research Projects (Competitive Research Funds)

Neurophysiological study on cognitive pathology of depression : relevant to anterior cingulate cortex
Ministry of Education, Culture, Sports, Science and Technology : Grants-in-Aid for Scientific Research(基盤研究(C))
Date (from‐to) : 2008-2010 Author : Ichiro KUSUMI
The role of endoplasmic reticulum stress response in the pathophysiology of bipolar disorder
Ministry of Education, Culture, Sports, Science and Technology : Grants-in-Aid for Scientific Research(基盤研究(C))
Date (from‐to) : 2005-2006 Author : Ichiro KUSUMI
Study of model for pathophysiology and mechanism for the treatment of the treatment resistant schizophrenia
Ministry of Education, Culture, Sports, Science and Technology : Grants-in-Aid for Scientific Research(基盤研究(C))
Date (from‐to) : 2003-2005 Author : Tomohiro ABEKAWA
Molecular biological study on the pathophysiology of bipolar disorders
Ministry of Education, Culture, Sports, Science and Technology : Grants-in-Aid for Scientific Research(基盤研究(C))
Date (from‐to) : 2003-2004 Author : Ichiro KUSUMI
The mechanism for the effects of atypical antipsychotics on the cognitive dysfunction of schizophreniavia the modulation of the function of the neuronal network
Ministry of Education, Culture, Sports, Science and Technology : Grants-in-Aid for Scientific Research(基盤研究(B))
Date (from‐to) : 2002-2004 Author : Tsukasa KOYAMA
Specification of factors that cause seasonality of birth in schizophrenia : a study for a clue to the preventive measure
Ministry of Education, Culture, Sports, Science and Technology : Grants-in-Aid for Scientific Research(基盤研究(C))
Date (from‐to) : 2002-2003 Author : Tsukasa SASAKI
Molecular biological study of mechanism of action of atypical antipsychotic drugs
Ministry of Education, Culture, Sports, Science and Technology : Grants-in-Aid for Scientific Research(基盤研究(C))
Date (from‐to) : 2001-2002 Author : Ichiro KUSUMI
Transmembranous signal transduction through G proteins : Implication for the pathophysiology of mental disorders
Ministry of Education, Culture, Sports, Science and Technology : Grants-in-Aid for Scientific Research(基盤研究(C))
Date (from‐to) : 1997-2000 Author : Yuji ODAGAKI
Study of mechanism of action of antipsychotic drugs in the animal model of schizophrenia
Ministry of Education, Culture, Sports, Science and Technology : Grants-in-Aid for Scientific Research(基盤研究(C))
Date (from‐to) : 1997-1999 Author : Ichiro KUSUMI
Neurochemical and pharmacological studies on the noves mode of action mechanisms of antipsychotic drugs : Preferential dopaminergic activation in the prefrontal cortex.
Ministry of Education, Culture, Sports, Science and Technology : Grants-in-Aid for Scientific Research(一般研究(B))
Date (from‐to) : 1993-1994 Author : Tsukasa KOYAMA
Display all
Research Projects (Competitive Research Funds)close
Neurophysiological study on cognitive pathology of depression : relevant to anterior cingulate cortex
Ministry of Education, Culture, Sports, Science and Technology : Grants-in-Aid for Scientific Research(基盤研究(C))
Date (from‐to) : 2008-2010 Author : Ichiro KUSUMI
The role of endoplasmic reticulum stress response in the pathophysiology of bipolar disorder
Ministry of Education, Culture, Sports, Science and Technology : Grants-in-Aid for Scientific Research(基盤研究(C))
Date (from‐to) : 2005-2006 Author : Ichiro KUSUMI
Study of model for pathophysiology and mechanism for the treatment of the treatment resistant schizophrenia
Ministry of Education, Culture, Sports, Science and Technology : Grants-in-Aid for Scientific Research(基盤研究(C))
Date (from‐to) : 2003-2005 Author : Tomohiro ABEKAWA
Molecular biological study on the pathophysiology of bipolar disorders
Ministry of Education, Culture, Sports, Science and Technology : Grants-in-Aid for Scientific Research(基盤研究(C))
Date (from‐to) : 2003-2004 Author : Ichiro KUSUMI
The mechanism for the effects of atypical antipsychotics on the cognitive dysfunction of schizophreniavia the modulation of the function of the neuronal network
Ministry of Education, Culture, Sports, Science and Technology : Grants-in-Aid for Scientific Research(基盤研究(B))
Date (from‐to) : 2002-2004 Author : Tsukasa KOYAMA
Specification of factors that cause seasonality of birth in schizophrenia : a study for a clue to the preventive measure
Ministry of Education, Culture, Sports, Science and Technology : Grants-in-Aid for Scientific Research(基盤研究(C))
Date (from‐to) : 2002-2003 Author : Tsukasa SASAKI
Molecular biological study of mechanism of action of atypical antipsychotic drugs
Ministry of Education, Culture, Sports, Science and Technology : Grants-in-Aid for Scientific Research(基盤研究(C))
Date (from‐to) : 2001-2002 Author : Ichiro KUSUMI
Transmembranous signal transduction through G proteins : Implication for the pathophysiology of mental disorders
Ministry of Education, Culture, Sports, Science and Technology : Grants-in-Aid for Scientific Research(基盤研究(C))
Date (from‐to) : 1997-2000 Author : Yuji ODAGAKI
Study of mechanism of action of antipsychotic drugs in the animal model of schizophrenia
Ministry of Education, Culture, Sports, Science and Technology : Grants-in-Aid for Scientific Research(基盤研究(C))
Date (from‐to) : 1997-1999 Author : Ichiro KUSUMI
Neurochemical and pharmacological studies on the noves mode of action mechanisms of antipsychotic drugs : Preferential dopaminergic activation in the prefrontal cortex.
Ministry of Education, Culture, Sports, Science and Technology : Grants-in-Aid for Scientific Research(一般研究(B))
Date (from‐to) : 1993-1994 Author : Tsukasa KOYAMA

Educational Activities

Classes

Principles of Medicine
Year : 2015
Principles of Medicine
Year : 2015
Principles of Medicine
Year : 2015
Master's Thesis Research in Medical Sciences Ⅰ
Year : 2015
Master's Thesis Research in Medical Sciences Ⅱ
Year : 2015
Basic Principles of Medicine
Year : 2015
Dissertation Research in Medical Sciences Ⅰ
Year : 2015
Dissertation Research in Medical Sciences Ⅱ
Year : 2015
Master's Thesis Research in Basic Medicine Ⅰ
Year : 2015
Master's Thesis Research in Basic Medicine Ⅱ
Year : 2015
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Principles of Medicine
Year : 2015
Principles of Medicine
Year : 2015
Principles of Medicine
Year : 2015
Master's Thesis Research in Medical Sciences Ⅰ
Year : 2015
Master's Thesis Research in Medical Sciences Ⅱ
Year : 2015
Basic Principles of Medicine
Year : 2015
Dissertation Research in Medical Sciences Ⅰ
Year : 2015
Dissertation Research in Medical Sciences Ⅱ
Year : 2015
Master's Thesis Research in Basic Medicine Ⅰ
Year : 2015
Master's Thesis Research in Basic Medicine Ⅱ
Year : 2015
Psychiatry
Year : 2015
Psychiatry
Year : 2015
PsychiatryⅢ
Year : 2015
Dissertation Research in Clinical Medicine Ⅰ
Year : 2015
Dissertation Research in Clinical Medicine Ⅱ
Year : 2015
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Principles of Medicine
Year : 2014
Master's Thesis Research in Medical Sciences Ⅰ
Year : 2014
Master's Thesis Research in Medical Sciences Ⅱ
Year : 2014
Basic Principles of Medicine
Year : 2014
Dissertation Research in Medical Sciences Ⅰ
Year : 2014
Dissertation Research in Medical Sciences Ⅱ
Year : 2014
Master's Thesis Research in Basic Medicine Ⅰ
Year : 2014
Master's Thesis Research in Basic Medicine Ⅱ
Year : 2014
Psychiatry
Year : 2014
PsychiatryⅢ
Year : 2014
Dissertation Research in Clinical Medicine Ⅰ
Year : 2014
Dissertation Research in Clinical Medicine Ⅱ
Year : 2014
Display all the previous two years
Classesclose
Principles of Medicine
Year : 2013
Master's Thesis Research in Medical Sciences Ⅰ
Year : 2013
Master's Thesis Research in Medical Sciences Ⅱ
Year : 2013
Basic Principles of Medicine
Year : 2013
Dissertation Research in Medical Sciences Ⅰ
Year : 2013
Dissertation Research in Medical Sciences Ⅱ
Year : 2013
Master's Thesis Research in Basic Medicine Ⅰ
Year : 2013
Master's Thesis Research in Basic Medicine Ⅱ
Year : 2013
PsychiatryⅢ
Year : 2013
Disertation Research in Clinical Medicine Ⅰ
Year : 2013
Disertation Research in Clinical Medicine Ⅱ
Year : 2013

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