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Kuwatani Masaki
| Hokkaido University Hospital Internal Medicine | Lecturer |
Researcher basic information
■ Degree■ URL
researchmap URLホームページURL■ Various IDs
ORCID IDJ-Global ID■ Research Keywords and Fields
Research KeywordResearch Field■ Educational Organization
- Master's degree program, Graduate School of Medicine
- Doctoral (PhD) degree program, Graduate School of Medicine
Research activity information
■ Awards- May 2024, 日本肝胆膵外科学会, JHBPS Best Reviewer Award 2023
- Feb. 2024, Japan Gastroenterological Endoscopy Society, Digestive Endoscopy Best Reviewers Award 2023
- Jun. 2023, Japanese Society of Hepato-Biliary-Pancreatic Surgery, Journal of Hepato-Biliary-Pancreatic Sciences Best Reviewer Award 2022
- Mar. 2023, Japan Gastroenterological Endoscopy Society, DEN Open: Best Reviewers Award 2022
- Feb. 2023, Japan Gastroenterological Endoscopy Society, Digestive Endoscopy Best Reviewers Award 2022
- Jan. 2023, 内視鏡医学研究振興財団, 2022年度研究助成B
抗体と低分子化合物を用いて膵癌細胞と癌関連線維芽細胞を標的とした内視鏡的二重光免疫療法の開発 - Jun. 2022, Japanese Society of Hepato-Biliary-Pancreatic Surgery, Journal of Hepato-Biliary-Pancreatic Sciences Best Reviewers Award 2021
- Jan. 2020, 内視鏡医学研究振興財団, 2019年度研究助成B
胆管癌に対する光感受性色素複合体を用いた内視鏡的光線免疫療法の開発 - Mar. 2019, Japan Gastroenterological Endoscopy Society, Digestive Endoscopy Best Reviewers Award 2018
- Jan. 2011, 内視鏡医学研究振興財団, 2010年度研究助成B
内視鏡的逆行性胆管膵管造影 (ERCP) の苦痛低減のためのCO2送気法の有用性に関する多施設共同無作為化二重盲検比較試験 - Sep. 2008, 秋山記念生命科学振興財団, 研究助成（一般）
骨髄移植後GVHDに対する胎児付属物由来間葉系幹細胞の効果
- Japanese Multi-Institution Study of Success Rates of Wire-Guided Biliary Cannulation During Endoscopic Retrograde Cholangiopancreatography in Relation to Guidewire tip Length (With Video).
Takeshi Ogura; Yuki Tanisaka; Masanari Sekine; Katsumasa Kobayashi; Hirotsugu Maruyama; Shinji Hirai; Hideyuki Shiomi; Minoru Shigekawa; Masaki Kuwatani; Kenji Ikezawa; Masahiro Itonaga; Mamoru Takenaka; Susumu Hijioka; Tsukasa Ikeura; Shinpei Doi; Nao Fujimori; Kazuya Koizumi; Yousuke Nakai; Tadahisa Inoue; Shuntaro Mukai; Kazuyuki Matsumoto; Ryuki Minami; Koichiro Mandai; Atsuhiro Matsuda; Takuji Iwashita; Hiroki Kawashima; Takao Itoi
DEN open, 6, 1, e70144, Apr. 2026, [International Magazine]
English, Scientific journal, OBJECTIVE: Wire-guided cannulation (WGC) reportedly increases the successful biliary cannulation rate and reduces the risk of post-endoscopic retrograde cholangiopancreatography pancreatitis. Currently, various types of guidewires are available. However, the effect of the length of flexible-tip guidewires on the success rate of biliary cannulation under WGC and the rate of adverse events, especially post-endoscopic retrograde cholangiopancreatography pancreatitis, is unclear. The aim of this study was to compare the influence of long-tapered and short-tapered tips of a 0.025-inch guidewire on outcomes in primary selective biliary cannulation. METHODS: Consecutive patients who underwent biliary access under endoscopic retrograde cholangiopancreatography guidance using WGC at 27 high-volume centers in Japan were enrolled in this prospective registration study. The primary outcome was the technical success rate of biliary cannulation. The secondary outcomes were the rates of adverse events, biliary cannulation time, and number of guidewire insertions into the pancreatic duct. RESULTS: A total of 530 patients underwent biliary cannulation for biliary disease with native papilla between April 2021 and December 2023. The technical success rate of biliary cannulation was 86.1% (161/187) in the long-tip group and 84.3% (289/343) in the short-tip group, indicating no significant differences between the two groups. Although the frequency of post-endoscopic retrograde cholangiopancreatography was not significantly different, the successful biliary cannulation rate without guidewire mis-insertion into the main pancreatic duct was significantly higher in the long tip group (64.7%, 121/187) compared with the short tip group (54.2%, 186/343p = 0.02). CONCLUSIONS: In conclusion, WGC using long-tip guidewires might reduce the risk of guidewire insertion into the main pancreatic duct. - High CD73 Expression Is Associated with Poor Prognosis in Biliary Tract Cancer Through Reduced Stromal Tumor-Infiltrating Lymphocytes
Shoya Shiratori; Kazumichi Kawakubo; Kanako C. Hatanaka; Takuma Kobayashi; Teppei Konishi; Yoshiki Shinomiya; Soichiro Oda; Shunichiro Nozawa; Hiroki Yonemura; Ryo Sugiura; Kazuaki Harada; Yoshitsugu Nakanishi; Takehiro Noji; Shinya Tanaka; Satoshi Hirano; Masaki Kuwatani; Yutaka Hatanaka; Naoya Sakamoto
Cancers, Mar. 2026
Scientific journal - Contrast-enhanced endoscopic ultrasound-guided additional ethanol ablation after early detection of occult residual pancreatic insulinoma
Ryo Sugiura; Masaki Kuwatani; Kazumichi Kawakubo; Shoya Shiratori; Soichiro Oda; Katsuma Nakajima; Naoya Sakamoto
Endoscopy, Mar. 2026
Scientific journal - Immediate or On-Demand Endoscopic Necrosectomy for Necrotizing Pancreatitis: A Randomized Controlled Trial (WONDER-01)
Tomotaka Saito; Toshio Fujisawa; Takeshi Ogura; Masaki Kuwatani; Hiroshi Ohyama; Mamoru Takenaka; Shinpei Doi; Keisuke Iwata; Shinichi Hashimoto; Hideki Kamada; Takuji Iwashita; Hideyuki Shiomi; Atsuhiro Masuda; Saburo Matsubara; Nobuhiko Hayashi; Akinori Maruta; Hirofumi Kogure; Tadahisa Inoue; Reiko Yamada; Toshiyasu Shiratori; Tsuyoshi Hamada; Saori Ueno; Atsushi Okuda; Sho Takahashi; Ryo Sugiura; Kazumichi Kawakubo; Koji Takahashi; Motoyasu Kan; Shunsuke Omoto; Tomohiro Yamazaki; Nobuhiro Katsukura; Mitsuru Okuno; Makoto Hinokuchi; Daisuke Namima; Shinya Uemura; Ryota Nakano; Arata Sakai; Kentaro Suda; Kensaku Yoshida; Kei Saito; Rena Kitano; Kenji Nose; So Nakaji; Tsuyoshi Mukai; Kazunari Nakahara; Kenji Chinen; Hiroyuki Isayama; Ichiro Yasuda; Yousuke Nakai
Gastroenterology, Elsevier BV, Feb. 2026
Scientific journal - Chronological change in subcutaneous adipose tissue radiodensity as a predictor of surgical outcome in patients with perihilar cholangiocarcinoma undergoing major hepatectomy
Ryo Sugiura; Masaki Kuwatani; Takehiro Noji; Kazumichi Kawakubo; Yoshitsugu Nakanishi; Kimitaka Tanaka; Satoshi Hirano; Naoya Sakamoto
Hepatobiliary & Pancreatic Diseases International, Elsevier BV, Jan. 2026
Scientific journal - DNMT3B Knockdown Enhances PARP Inhibitor Sensitivity in Biliary Tract Cancer Cells via Opioid Growth Factor Receptor-Mediated Homologous Recombination Impairment
Soichiro Oda; Kazumichi Kawakubo; Masaki Kuwatani; Shugo Tanaka; Katsuma Nakajima; Shoya Shiratori; Hiroki Yonemura; Shunichiro Nozawa; Koji Hirata; Ryo Sugiura; Naoya Sakamoto
Cancers, 09 Dec. 2025
Scientific journal - Efficacy of Perfusion Computed Tomography in Early Prediction of Post–Endoscopic Retrograde Cholangiopancreatography Pancreatitis
Shunichiro Nozawa; Masaki Kuwatani; Ryosuke Shimura; Ryo Sugiura; Kazumichi Kawakubo; Kosuke Nagai; Kazuma Kishi; Hiroki Yonemura; Yusuke Sakuhara; Kohsuke Kudo; Naoya Sakamoto
Pancreas, 55, 1, e33, e40, Ovid Technologies (Wolters Kluwer Health), 18 Sep. 2025
Scientific journal, Background:
Endoscopic retrograde cholangiopancreatography (ERCP) is essential for diagnosing and treating pancreaticobiliary diseases, but post-ERCP pancreatitis (PEP) is a common and potentially severe complication. Perfusion computed tomography (CT) is a method for analyzing blood flow by capturing sequential images after rapid intravenous contrast injection, however, its usefulness in the early detection of PEP is unclear. This study aimed to assess whether ERCP followed by perfusion CT could predict PEP at an early phase.
Methods:
This single-center prospective study included 49 patients (25 women, 24 men; median age, 70 y) who underwent ERCP, who were at high risk for PEP, and who underwent perfusion CT within 2 hours after ERCP. All patients underwent perfusion assessment of blood volume (BV), blood flow (BF), mean transit time (MTT), and time to peak (TTP).
Results:
PEP occurred in 13 patients (26.5%). The PEP group had higher BF and shorter MTT and TTP than the non-PEP group ( P < 0.01). Receiver operating characteristic analysis identified BV, BF, MTT, and TTP as good predictive markers for PEP (with areas under the curve of 0.624, 0.739, 0.735, and 0.748, respectively). The respective sensitivity and specificity for the diagnosis of PEP were as follows: BV, 84.6% and 50.0%; BF, 61.5% and 91.7%; MTT, 84.6% and 66.7%; TTP, 84.6% and 69.4%; serum amylase, 61.5% and 86.1%. The sensitivity and specificity of TTP combined with serum amylase increased to 76.9% and 88.9%, respectively.
Conclusions:
Early perfusion CT findings after ERCP could predict PEP development in high-risk patients. - Hepatocellular carcinoma with recurrent pancreatic metastasis 17 years after radical resection.
Soichiro Oda; Kazumichi Kawakubo; Shoya Shiratori; Hiroki Yonemura; Shunichiro Nozawa; Ryo Sugiura; Masaki Kuwatani; Noriyuki Otsuka; Shinichi Nakazato; Utano Tomaru; Naoya Sakamoto
Clinical journal of gastroenterology, 21 Jul. 2025, [Domestic magazines]
English, Scientific journal, Hepatocellular carcinoma (HCC) has a high recurrence rate, typically within 2 years after surgical radical resection. Pancreatic metastasis from HCC is extremely rare. We present the first case of pancreatic metastasis from HCC recurring 17 years after radical hepatic lobectomy. - What is the ideal shape of a self‐expandable metal stent with no migration or obstruction?
Masaki Kuwatani
Digestive Endoscopy, 09 Jun. 2025, [International Magazine]
English, Scientific journal - Clinical outcomes of initial inside stenting for preoperative malignant hilar biliary obstruction in patients with jaundice.
Ryo Sugiura; Masaki Kuwatani; Kazumichi Kawakubo; Hiroki Yonemura; Shunichiro Nozawa; Shoya Shiratori; Soichiro Oda; Kimitaka Tanaka; Satoshi Hirano; Naoya Sakamoto
Surgery today, 14 May 2025, [Domestic magazines]
English, Scientific journal, PURPOSE: Endoscopic nasobiliary drainage (ENBD) is a widely used primary approach for preoperative endoscopic biliary drainage (PEBD) for malignant hilar biliary obstruction (MHBO) although the utility of inside stenting (IS) remains unknown. This study aimed to compare the clinical outcomes of IS and ENBD as the initial PEBD. METHODS: This retrospective, single-center study included patients with MHBO who underwent IS or ENBD as the initial PEBD and before laparotomy for radical surgical resection at the study institution. The primary outcome was the clinical success rate of the initial PEBD method. RESULTS: The study included 28 and 38 patients who underwent IS and ENBD, respectively, for initial PEBD. The clinical success rates in patients who underwent IS and ENBD were 78.6% and 97.4%, respectively (P = 0.04). Clinical failure was more frequent in patients with jaundice undergoing IS (42.9%) than in those without jaundice undergoing IS and those with or without jaundice undergoing ENBD (0-4.2%; P < 0.01). The rates of cholangitis and PEBD-related adverse events, the cumulative incidence of PEBD dysfunction, and postoperative survival in patients undergoing IS and ENBD did not differ to a statistically significant extent. CONCLUSIONS: Clinical failure of initial PEBD was more frequent in patients with jaundice undergoing IS than in those undergoing ENBD during the initial preoperative period of workup and drainage period. - Treatment of Pancreatic Cancer Using Near-Infrared Photoimmunotherapy Targeting Cancer-Associated Fibroblasts in Combination with Anticancer Chemotherapeutic Drug
Hiroki Yonemura; Masaki Kuwatani; Kohei Nakajima; Atsushi Masamune; Mikako Ogawa; Naoya Sakamoto
Cancers, 07 May 2025
Scientific journal - Rare Pancreatic Neuroendocrine Tumor With Hyalinization Exhibiting Atypical Imaging Features: A Case Report.
Shoya Shiratori; Ryo Sugiura; Masaki Kuwatani; Soichiro Oda; Shunichiro Nozawa; Hiroki Yonemura; Kazuma Kishi; Kazumichi Kawakubo; Aya Matsui; Satoshi Hirano; Satoko Yorinaga; Tomoko Mitsuhashi; Naoya Sakamoto
Pancreas, 54, 5, e499-e501, 01 May 2025, [International Magazine]
English, Scientific journal - Panniculitis of the Lower Extremities Caused by Acute Deterioration of Autoimmune Pancreatitis
Soichiro Oda; Masaki Kuwatani; Shoya Shiratori; Hiroki Yonemura; Syunichiro Nozawa; Ryo Sugiura; Kazumichi Kawakubo; Kazuki Watanabe; Mika Watanabe; Naoya Sakamoto
Journal of Gastroenterology and Hepatology, May 2025
Scientific journal - 特集 ここまでできる! プライマリケア-領域別で考えるプライマリケア医と専門医の役割 第7章:肝･胆･膵 [胆管拡張,胆管狭窄]胆管炎,胆管結石,膵胆道がん
桒谷 将城; 坂本 直哉
内科, 135, 4, 878, 883, 南江堂, 01 Apr. 2025 - Endoscopic treatment for pancreatic fluid collections: Is active intervention always the optimal option?
Masaki Kuwatani
Digestive Endoscopy, 37, 4, 426, 427, Apr. 2025, [International Magazine]
English, Scientific journal - Complete clearance of painless pancreatic stones with endotherapy prevents the progression of pancreatic parenchyma atrophy in patients with chronic pancreatitis: Multicenter cohort study.
Tsukasa Ikeura; Ayaka Takaori; Kazuhiro Kikuta; Ken Ito; Tetsuya Takikawa; Takaaki Eguchi; Tadahisa Inoue; Yasuki Hori; Kenji Nakamura; Mamoru Takenaka; Yoshio Sogame; Tadayuki Takagi; Nao Fujimori; Satoshi Yamamoto; Akira Nakamura; Toshitaka Sakai; Arata Sakai; Takashi Tamura; Tomotaka Saito; Koichi Fujita; Atsushi Kanno; Kunihiro Hosono; Keisuke Iwata; Atsushi Irisawa; Kazuhisa Okamoto; Masaki Kuwatani; Makoto Naganuma; Atsushi Masamune; Yoshifumi Takeyama
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 27 Feb. 2025, [International Magazine]
English, Scientific journal, OBJECTIVES: This retrospective multicenter study aimed to clarify the clinical impact of endotherapy for painless pancreatic duct (PD) stones compared with that in patients who received conservative treatment without endotherapy. METHODS: We enrolled 268 patients suffering from chronic pancreatitis with painless PD stones (145 with endotherapy and 123 without endotherapy) and evaluated the impact of endotherapy for painless PD stones on clinical and radiological outcomes. RESULTS: When conservative treatment without endotherapy was set as a reference, complete clearance of the targeted PD stones decreased the relative risk for atrophy of pancreatic parenchyma after inclusion (hazard ratio [HR] 0.42; 95% confidence interval [CI] 0.21-0.84). Incomplete clearance of the targeted PD stones was identified as a risk factor for new-onset or worsening of diabetes (HR 2.08; 95% CI 1.10-3.91) and inducement of pain attack (HR 4.03; 95% CI 1.45-11.19), although complete clearance was not correlated with these outcomes. CONCLUSION: In chronic pancreatitis patients with painless PD stones, endotherapy with complete stone clearance allows the maintenance of pancreatic parenchymal volume. However, if complete clearance fails, endotherapy could lead to aggravation of glucose tolerance and pain attacks during follow-up. - Uncovered Self-Expandable Metallic Stent with an Ultra-Thin Delivery Sheath in Unresectable Malignant Hilar Biliary Obstruction: A Multicenter Prospective Observational Study.
Kotaro Takeshita; Susumu Hijioka; Kenji Ikezawa; Takeshi Ogura; Masaki Kuwatani; Nao Fujimori; Shinpei Doi; Masato Endo; Saburo Matsubara; Reiko Yamada; Hirosato Mashima; Mikinori Kataoka; Ryoji Takada; Atsushi Okuda; Akihisa Ohno; Nobuhiro Katsukura; Hirosumi Suzuki; Takamitsu Tanaka; Masanari Sekine; Hidetoshi Kitamura; Takuji Okusaka
Digestive diseases and sciences, 19 Feb. 2025, [International Magazine]
English, Scientific journal, BACKGROUND: Although various self-expandable metallic stents (SEMSs) for malignant hilar biliary obstruction (MHBO) have been introduced, the optimal SEMS for MHBO has not yet been established. PURPOSE: This study aimed to evaluate outcomes of the transpapillary placement of an uncovered laser-cut SEMS with an ultra-thin delivery sheath (YABUSAME) for MHBO. METHODS: This multicenter, prospective study was conducted in 11 hospitals for 10 months (from March 2022 to December 2022). The primary outcome was the stent patency rate at 6 months. Key secondary outcomes were the technical success rate, clinical success rate, time to recurrent biliary obstruction (RBO), overall survival (OS), and adverse events. RESULTS: Of 45 enrolled patients, 43 patients underwent biliary drainage, including 42 patients who underwent YABUSAME placement; 66.7% of patients received chemotherapy, and 60% had previously undergone biliary drainage. Drainage methods were partial stent-in-stent, side-by-side, and unilateral in 65.1%, 7.0%, and 27.9% of patients, respectively. Technical and clinical success rates were 93.2% (41/45) and 79.1% (34/45), respectively. The incidence rate of early postprocedural adverse events was 2.2%. The stent patency rate at 6 months was 55.3%. The median time to RBO was 231 days. The median OS was 125 days. CONCLUSION: This study showed that the primary outcome, the 6-month stent patency rate, exceeded the expected rate of 55%, which indicates the efficacy of YABUSAME placement for MHBO. - Subcutaneous adipose tissue radiodensity as a predictor of poor prognosis in advanced biliary tract cancer
Ryo Sugiura; Yasuyuki Kawamoto; Masaki Kuwatani; Kazumichi Kawakubo; Kazuaki Harada; Masatsugu Ohara; Hiroki Yonemura; Shunichiro Nozawa; Naoya Sakamoto
Journal of Hepato-Biliary-Pancreatic Sciences, 32, 3, 194, 202, Wiley, 08 Jan. 2025, [Domestic magazines]
English, Scientific journal, Abstract
Background
High subcutaneous adipose tissue radiodensity (SATr), an indirect surrogate marker of adipose tissue quality, was associated with poor prognosis in various cancers. The present study aimed to assess the association of SATr with survival outcomes in patients with advanced biliary tract cancer (BTC).
Methods
This retrospective, single‐center study included patients with unresectable or recurrent BTC who underwent chemotherapy/chemoradiotherapy. Overall survival (OS) and progression‐free survival (PFS) were assessed using the log‐rank test and the Cox proportional hazards model according to the SATr status.
Results
The study cohort included 234 patients, including 38 and 196 patients with high and non‐high SATr, respectively. The median OS durations were 10.5 and 17.4 months (HR = 1.72, 95% CI: 1.19–2.49, p < .01) and the median PFS durations were 4.9 and 8.0 months (HR = 1.52, 95% CI: 1.05–2.20, p = .03) in patients with high and non‐high SATr, respectively. By multivariate analysis, high SATr, neutrophil/lymphocyte ratio >5, modified Glasgow prognostic score 1–2, and serum carcinoembryonic antigen >5.0 ng/mL were predictors for OS (HR, 1.66, 2.42, 2.00, and 1.56, respectively; p < .05). By multivariate analysis, metastatic disease status, high SATr, neutrophil/lymphocyte ratio >5, and modified Glasgow prognostic score 1–2 were independent risk factors for worse PFS (HR, 1.56, 1.56, 1.81, and 1.57, respectively; p < .05).
Conclusions
High SATr was associated with risk of tumor progression and poor prognosis in patients with advanced BTC treated by palliative chemotherapy/chemoradiotherapy. - Efficacy and Safety of Endoscopic Ultrasonography-Guided Ethanol Injections of Small Pancreatic Neuroendocrine Neoplasms: a prospective, multicenter study.
Kazuyuki Matsumoto; Hironari Kato; Takao Itoi; Masayuki Kitano; Kazuo Hara; Masaki Kuwatani; Mamoru Takenaka; Reiko Ashida; Shuntaro Mukai; Nozomi Okuno; Kazumichi Kawakubo; Tatsuhiro Yamazaki; Jun Sakurai; Yuki Nakatsuka; Michihiro Yoshida; Motoyuki Otsuka
Endoscopy, 57, 4, 321, 329, 25 Oct. 2024, [International Magazine]
English, Scientific journal, BACKGROUND AND STUDY AIMS: Endoscopic ultrasonography (EUS)-guided ethanol injection (EI) has recently been introduced as one of the management strategies for pancreatic neuroendocrine neoplasms (PNENs). However, its role as a surgical alternative is unclear. We evaluated the efficacy and safety of EUS-EI in treating small PNENs through a prospective multicentre study. PATIENTS AND METHODS: Patients with Grade 1 tumours of ≤15 mm confirmed by pathology were included. The primary endpoint assessed efficacy and safety, measuring complete ablation using computed tomography at 1 and 6 months, prevention of adverse events (AEs) within 1 month, severe pancreatic fistula at 1 month, and diabetes mellitus (DM) incidence/worsening at 6 months. The composite endpoint of EUS-EI was compared with that of historical results of a study based on surgical treatment. RESULTS: Twenty-five patients with PNENs, with a median tumour size of 10.1 mm, were treated using EUS-EI. Seventy-six percent of the patients achieved the composite primary endpoint (19/25) (95% confidence interval [CI]=54.9%-90.6%), a proportion significantly higher than that of surgical treatment (P=0.0083). Regarding efficacy, 88% (22/25) of the patients achieved complete ablation at 1 and 6 months (95% CI=68.8%-97.5%). Regarding safety, 96% (24/25) of the patients had no severe AEs within 1 month (95% CI=79.7%-99.9%). No patients had severe pancreatic fistulas at 1 month, and 84% (21/25) of the patients had no incidence or exacerbation, or both, of DM at 6 months (95% CI=63.9%-95.5%). CONCLUSION: EUS-EI is safe and could be a potent treatment option for patients with small PNENs. - WONDER-02: plastic stent vs. lumen-apposing metal stent for endoscopic ultrasound-guided drainage of pancreatic pseudocysts-study protocol for a multicentre randomised non-inferiority trial.
Tomotaka Saito; Mamoru Takenaka; Masaki Kuwatani; Shinpei Doi; Hiroshi Ohyama; Toshio Fujisawa; Atsuhiro Masuda; Takuji Iwashita; Hideyuki Shiomi; Nobuhiko Hayashi; Keisuke Iwata; Akinori Maruta; Tsuyoshi Mukai; Saburo Matsubara; Tsuyoshi Hamada; Tadahisa Inoue; Kazuyuki Matsumoto; Sumio Hirose; Nao Fujimori; Kosuke Kashiwabara; Hideki Kamada; Shinichi Hashimoto; Toshiyasu Shiratori; Reiko Yamada; Hirofumi Kogure; Kazunari Nakahara; Takeshi Ogura; Masayuki Kitano; Ichiro Yasuda; Hiroyuki Isayama; Yousuke Nakai
Trials, 25, 1, 559, 559, 24 Aug. 2024, [International Magazine]
English, Scientific journal, BACKGROUND: Endoscopic ultrasound (EUS)-guided transluminal drainage has become a first-line treatment modality for symptomatic pancreatic pseudocysts. Despite the increasing popularity of lumen-apposing metal stents (LAMSs), plastic stents may resolve non-necrotic fluid collections effectively with lower costs and no LAMS-specific adverse events. To date, there has been a paucity of data on the appropriate stent type in this setting. This trial aims to assess the non-inferiority of plastic stents to a LAMS for the initial EUS-guided drainage of pseudocysts. METHODS: The WONDER-02 trial is a multicentre, open-label, non-inferiority, randomised controlled trial, which will enrol pancreatic pseudocyst patients requiring EUS-guided treatment in 26 centres in Japan. This trial plans to enrol 80 patients who will be randomised at a 1:1 ratio to receive either plastic stents or a LAMS (40 patients per arm). In the plastic stent group, EUS-guided drainage will be performed using two 7-Fr double pigtail stents. In the LAMS group, the treatment will be performed in the same way except for LAMS use. The step-up treatment will be performed via endoscopic and/or percutaneous procedures at the trial investigator's discretion. The primary endpoint is clinical success, which is defined as a decrease in a pseudocyst size to ≤ 2 cm and an improvement in inflammatory indicators (i.e. body temperature, white blood cell count, and serum C-reactive protein). Secondary endpoints include technical success, adverse events including mortality, pseudocyst recurrence, and medical costs. DISCUSSION: The WONDER-02 trial will investigate the efficacy and safety of plastic stents compared to a LAMS in EUS-guided treatment of symptomatic pancreatic pseudocysts with a particular focus on the non-inferior efficacy of plastic stents. The findings will help establish a new treatment algorithm for this population. TRIAL REGISTRATION: ClinicalTrials.gov NCT06133023 registered on 9 November 2023. UMIN000052647 registered on 30 October 2023. jRCT1032230444 registered on 7 November 2023. - Diagnosis of isolated hilar-/extrahepatic-type IgG-4-related sclerosing cholangitis can be increased by improved recognition of this condition-A Japanese multicenter analysis.
Kensuke Kubota; Eisuke Iwasaki; Takuya Ishikawa; Masaki Kuwatani; Mamoru Takenaka; Takuji Iwashita; Atsuhiro Masuda; Tsukasa Ikeura; Akira Nakamura; Atsushi Tanaka; Hiroyuki Isayama; Yoshiki Hirooka; Kenji Hirano; Shomei Ryozawa; Takeshi Ogura; Toshio Fujisawa; Yusuke Kurita; Kazuhiro Kikuta; Nobuhiko Hayashi; Atsushi Masamune; Ichiro Yasuda
Journal of hepato-biliary-pancreatic sciences, 31, 9, 647, 657, 09 Aug. 2024, [Domestic magazines]
English, Scientific journal, BACKGROUND: Patients with isolated IgG4-related sclerosing cholangitis (IgG4-SC) often undergo unnecessary resection. The aim of this study was to validate the revised Japanese diagnostic criteria for isolated IgG-4-SC and to improve awareness about this condition in the population. METHODS: This was a Japanese retrospective multicenter study. We focused on the data and diagnostic yield obtained using the Japanese diagnostic criteria published initially in 2012 and revised later in 2020 for the diagnosis of isolated IgG4-SC. RESULTS: Patients with isolated IgG4-SC could be classified into two groups based on the primary location of the lesion: the hilar type (n = 40) and the extrahepatic type (n = 13). In total, 10 patients with the hilar type had undergone unnecessary resection. The revised 2020 criteria are useful for the diagnosis of extrahepatic lesions, which are not included in the 2012 criteria. The need for a steroid trial was reduced from 37.7% when the diagnosis was based on the 2012 criteria to 7.6% when the diagnosis was based on the revised 2020 criteria. The diagnostic specificity also improved from 58.5% for the 2012 criteria to 88.7% for the revised 2020 criteria. CONCLUSION: Our validation of the 2020 criteria for the diagnosis of IgG4-SC could contribute to avoiding unnecessary resection in patients with isolated IgG4-SC, which can be classified into the hilar and extrahepatic types. The 2020 criteria can enhance the diagnosis rate of isolated IgG4-SC and uncover this tough-to-diagnose entity based on inclusion of the imaging findings and decrease the dependence on a steroid trial. - Risk factors for recurrent biliary obstruction following endoscopic biliary stenting in patients with unresectable ampullary cancer: A multicenter retrospective study
Ryo Sugiura; Masaki Kuwatani; Toshifumi Kin; Ryusuke Matsumoto; Yuki Ikeda; Itsuki Sano; Koji Hirata; Makoto Yoshida; Yoshiharu Masaki; Michihiro Ono; Hajime Hirata; Hiroaki Yamato; Manabu Onodera; Hideaki Nakamura; Yoko Taya; Nobuyuki Ehira; Masahito Nakajima; Hidemasa Kawabata; Hideyuki Ihara; Taiki Kudo; Shin Kato; Akio Katanuma
Journal of Digestive Diseases, 25, 5, 310, 317, Wiley, 20 Jun. 2024, [International Magazine]
English, Scientific journal, Objectives
Unresectable ampullary cancer (AC) is a rare disease entity. The risk factors for recurrent biliary obstruction (RBO) following endoscopic biliary stenting (EBS) for unresectable AC remain unknown. In this study we aimed to evaluate the cumulative RBO rate and to identify risk factors for RBO following palliative EBS in patients with unresectable AC.
Methods
This multicenter retrospective observational study enrolled consecutive patients with unresectable AC who had undergone palliative EBS between April 2011 and December 2021. The cumulative rate of and risk factors for RBO following palliative EBS were evaluated via multivariate analysis.
Results
The study analysis comprised 107 patients with a median age of 84 years (interquartile range 79–88 years). Plastic stents (PSs) and self‐expandable metal stents (SEMSs) were placed in 53 and 54 patients, respectively. Functional success was accomplished in 104 (97.2%) patients. Of these, RBO occurred in 62 (59.6%) patients, with obstruction and complete/partial migration occurring in 47 and 15 patients, respectively. The median time to RBO was 190 days. Multivariate analysis showed that PS was associated with a higher rate of RBO compared to SEMS (hazard ratio [HR] 2.48; P < 0.01) and that the presence of common bile duct stones/sludge immediately after EBS was an independent risk factor for RBO (HR 1.99; P = 0.04).
Conclusions
The use of SEMS compared to PS during EBS reduced the time to RBO in patients with unresectable AC. Common bile duct stones/sludge immediately after EBS was a risk factor for RBO. - Preoperative risk factors for skeletal muscle mass loss in patients with biliary tract cancer
Ryo Sugiura; Masaki Kuwatani; Kazumichi Kawakubo; Kazuma Kishi; Hiroki Yonemura; Shunichiro Nozawa; Masatsugu Ohara; Takehiro Noji; Satoshi Hirano; Naoya Sakamoto
Journal of Hepato-Biliary-Pancreatic Sciences, 31, 8, 549, 558, Wiley, 06 Jun. 2024, [Domestic magazines]
English, Scientific journal, Abstract
Background
Endoscopic retrograde cholangiography (ERC)‐related procedures, usually performed before biliary tract cancer (BTC) surgery, are associated with increased risk for various complications, which can cause sarcopenia. No study has previously elucidated the relationship between preoperative ERC‐related procedures and sarcopenia/skeletal muscle mass loss.
Methods
Patients with BTC who underwent radical surgical resection following ERC‐related procedures were included. Skeletal muscle mass was evaluated using the psoas muscle mass index (PMI), which was determined using computed tomography images, and the change in PMI before the initial pre‐ERC and surgery (ΔPMI) was calculated. Risk factors for advanced skeletal muscle mass loss, defined as a large ΔPMI, were evaluated.
Results
The study cohort included 90 patients with a median age of 72 (interquartile range, 65–75) years. The median PMI pre‐ERC and surgery was 4.40 and 4.15 cm2/m2, respectively (p < .01). The median ΔPMI was −6.2% (interquartile range, −10.9% to 0.5%). By multivariate analysis, post‐ERC pancreatitis and cholangitis before surgery were independent predictive factors for large PMI loss (odds ratio, 4.57 and 3.18, respectively; p = .03 and p = .02, respectively).
Conclusions
Skeletal muscle mass decreases preoperatively in most patients with BTC undergoing ERC. Post‐ERC pancreatitis and cholangitis before surgery were independent risk factors for large skeletal muscle mass loss. - GGT1 is a SNP eQTL gene involved in STAT3 activation and associated with the development of Post-ERCP pancreatitis.
Ryutaro Furukawa; Masaki Kuwatani; Jing-Jing Jiang; Yuki Tanaka; Rie Hasebe; Kaoru Murakami; Kumiko Tanaka; Noriyuki Hirata; Izuru Ohki; Ikuko Takahashi; Takeshi Yamasaki; Yuta Shinohara; Shunichiro Nozawa; Shintaro Hojyo; Shimpei I Kubota; Shigeru Hashimoto; Satoshi Hirano; Naoya Sakamoto; Masaaki Murakami
Scientific reports, 14, 1, 12224, 12224, 28 May 2024, [International Magazine]
English, Scientific journal, Post-ERCP pancreatitis (PEP) is an acute pancreatitis caused by endoscopic-retrograde-cholangiopancreatography (ERCP). About 10% of patients develop PEP after ERCP. Here we show that gamma-glutamyltransferase 1 (GGT1)-SNP rs5751901 is an eQTL in pancreatic cells associated with PEP and a positive regulator of the IL-6 amplifier. More PEP patients had the GGT1 SNP rs5751901 risk allele (C) than that of non-PEP patients at Hokkaido University Hospital. Additionally, GGT1 expression and IL-6 amplifier activation were increased in PEP pancreas samples with the risk allele. A mechanistic analysis showed that IL-6-mediated STAT3 nuclear translocation and STAT3 phosphorylation were suppressed in GGT1-deficient cells. Furthermore, GGT1 directly associated with gp130, the signal-transducer of IL-6. Importantly, GGT1-deficiency suppressed inflammation development in a STAT3/NF-κB-dependent disease model. Thus, the risk allele of GGT1-SNP rs5751901 is involved in the pathogenesis of PEP via IL-6 amplifier activation. Therefore, the GGT1-STAT3 axis in pancreas may be a prognosis marker and therapeutic target for PEP. - Gastrointestinal: Solid pseudopapillary neoplasm of the pancreas with high‐grade malignant transformation
N Wakabayashi; R Kimura; M Kuwatani; A Matsui; N Ino; T Mitsuhashi; K Kishi; S Tsuneta; J Nakagawa; N Nishioka; K Sakamoto; F Kato; A Shimizu; S Hirano; K Kudo
Journal of Gastroenterology and Hepatology, Apr. 2024
Scientific journal - Interventional EUSの現状と展開 小病変の膵神経内分泌腫瘍(G1)に対する超音波内視鏡下エタノール注入療法の有効性と安全性の検証 多施設共同前向き介入研究
向井 俊太郎; 松本 和幸; 加藤 博也; 山崎 辰洋; 北野 雅之; 蘆田 玲子; 桑谷 将城; 原 和生; 竹中 完; 糸井 隆夫
日本消化器病学会雑誌, 121, 臨増総会, A151, A151, (一財)日本消化器病学会, Mar. 2024
Japanese - ERCP using balloon-assisted endoscopes versus EUS-guided treatment for common bile duct stones in Roux-en-Y gastrectomy.
Tatsuya Sato; Yousuke Nakai; Hirofumi Kogure; Toshiyuki Mitsuyama; Masaaki Shimatani; Shinya Uemura; Takuji Iwashita; Yuki Tanisaka; Shomei Ryozawa; Takayoshi Tsuchiya; Takao Itoi; Toshifumi Kin; Akio Katanuma; Ken Kashima; Atsushi Irisawa; Atsuto Kayashima; Eisuke Iwasaki; Akihiro Yoshida; Mamoru Takenaka; Hitomi Himei; Hironari Kato; Atsuhiro Masuda; Hideyuki Shiomi; Kazumichi Kawakubo; Masaki Kuwatani; Takeshi Otsuka; Saburo Matsubara; Nobu Nishioka; Takeshi Ogura; Takaaki Tamura; Masayuki Kitano; Nobuhiko Hayashi; Ichiro Yasuda; Mitsuhiro Fujishiro
Gastrointestinal endoscopy, 99, 2, 193, 203, Feb. 2024, [International Magazine]
English, Scientific journal, BACKGROUND AND AIMS: We compared ERCP using a balloon-assisted endoscope (BE-ERCP) with EUS-guided antegrade treatment (EUS-AG) for removal of common bile duct (CBD) stones in patients with Roux-en-Y (R-Y) gastrectomy. METHODS: Consecutive patients who had previous R-Y gastrectomy undergoing BE-ERCP or EUS-AG for CBD stones in 16 centers were retrospectively analyzed. RESULTS: BE-ERCP and EUS-AG were performed in 588 and 59 patients, respectively. Baseline characteristics were similar, except for CBD diameter and angle. The technical success rate was 83.7% versus 83.1% (P = .956), complete stone removal rate was 78.1% versus 67.8% (P = .102), and early adverse event rate was 10.2% versus 18.6% (P = .076) in BE-ERCP and EUS-AG, respectively. The mean number of endoscopic sessions was smaller in BE-ERCP (1.5 ± .8 vs 1.9 ± 1.0 sessions, P = .01), whereas the median total treatment time was longer (90 vs 61.5 minutes, P = .001). Among patients with biliary access, the complete stone removal rate was significantly higher in BE-ERCP (93.3% vs 81.6%, P = .009). Negative predictive factors were CBD diameter ≥15 mm (odds ratio [OR], .41) and an angle of CBD <90 degrees (OR, .39) in BE-ERCP and a stone size ≥10 mm (OR, .07) and an angle of CBD <90 degrees (OR, .07) in EUS-AG. The 1-year recurrence rate was 8.3% in both groups. CONCLUSIONS: Effectiveness and safety of BE-ERCP and EUS-AG were comparable in CBD stone removal for patients after R-Y gastrectomy, but complete stone removal after technical success was superior in BE-ERCP. - Reconsidering resectable oncological conditions in pancreatic tail cancer: A multicenter retrospective study on prognostic factors in pancreatic tail cancer after resection (HOPS Pt-01).
Yasutoshi Kimura; Toru Nakamura; Masafumi Imamura; Minoru Nagayama; Takeshi Murakami; Tsuyoshi Hayashi; Toru Kato; Kimitaka Tanaka; Makoto Yoshida; Kazuharu Kukita; Koji Imai; Makoto Yoshida; Yoshiharu Masaki; Masayo Motoya; Masaki Kuwatani; Masayuki Koyama; Hirofumi Ohnishi; Ichiro Takemasa
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 12 Dec. 2023, [International Magazine]
English, Scientific journal, BACKGROUND: Pancreatic tail cancer (Pt-PC) is generally considered resectable when metastasis is absent, but doubts persist in clinical practice due to the variability in local tumor extent. We conducted a multicenter retrospective study to comprehensively identify prognostic factors associated with Pt-PC after resection. METHODS: We enrolled 100 patients that underwent distal pancreatectomy. The optimal combination of factors influencing relapse-free survival (RFS) was determined using the maximum likelihood method (MLM) and corrected Akaike and Bayesian information criteria (AICc and BIC). Prognostic elements were then validated to predict oncological outcomes. RESULTS: Therapeutic interventions included neoadjuvant treatment in 16 patients and concomitant visceral resection (CVR) in 37 patients; 89 patients achieved R0. Median RFS and OS after surgery were 23.1 and 37.1 months, respectively. AICc/BIC were minimized in the model with ASA-PS (≥2), CA19-9 (≥112 U/mL at baseline, non-normalized postoperatively), need for CVR, 6 pathological items (tumor diameter ≥19.5 mm, histology G1, invasion of the anterior pancreatic border, splenic vein invasion, splenic artery invasion, lymph node metastasis), and completed adjuvant treatment (cAT) for RFS. Regarding the predictive value of these 11 factors, area under the curve was 0.842 for 5-year RFS. Multivariate analysis of these 11 factors showed that predictors of RFS include CVR (hazard ratio, 2.13; 95 % confidence interval, 1.08-4.19; p = 0.028) and cAT (0.38, 0.19-0.76; p = 0.006). CONCLUSIONS: The MLM identified certain Pt-PC cases warranting consideration beyond resectable during clinical management. Particular attention should be paid to conditions requiring CVR, even though immortal time bias remains unresolved with adjuvant treatment. - Two-step pancreatic duct stenting with endoscopic ultrasonography and balloon-assisted enteroscopy for pancreaticojejunal anastomotic stricture
Kosuke Nagai; Masaki Kuwatani; Yunosuke Takishin; Ryutaro Furukawa; Hajime Hirata; Kazumichi Kawakubo; Naoya Sakamoto
Endoscopy, Dec. 2023
Scientific journal - Utility of a Passive Bending Colonoscope for Endoscopic Retrograde Cholangiopancreatography in Patients with Surgically Altered Anatomy.
Shin Kato; Yuji Ono; Michio Nakamura; Ryo Fukino; Asako Nomura; Mariko Matsumura; Taichi Murai; Kazufumi Itaya; Yuta Koike; Takaaki Izumi; Ayana Endo; Shuji Nishikawa; Masaki Kuwatani
Digestive diseases and sciences, 06 Nov. 2023, [International Magazine]
English, Scientific journal, BACKGROUND AND AIM: The utility of a passive bending colonoscope (PBCS) in ERCP for patients with surgically altered anatomy has not been established. This study compared the outcome of PBCS-ERCP and balloon-assisted enteroscope (BAE)-ERCP. METHODS: This multicenter observational study included 343 patients with surgically altered anatomy who underwent ERCP. Among these, 110 underwent PBCS-ERCP and 233 underwent BAE-ERCP. Propensity score matching was applied, and a final cohort of 210 (105 in each group) with well-balanced backgrounds was analyzed. The primary outcome was the success rate of reaching anastomosis or ampulla of Vater. Secondary endpoints included the cannulation success rate, completion rate, procedure time (to reach, cannulate, complete), and adverse events. RESULTS: The success rate for reaching the target was 91.4% (96/105) with PBCS and 90.5% (95/105) with BAE (odds ratio [95% CI] 1.12, [0.44-2.89], P = 0.809). The mean time required to reach the target was significantly shorter in PBCS: 10.04 min (SD, 9.62) with PBCS versus 18.77 min (SD, 13.21) with BAE (P < 0.001). There were no differences in the success of cannulation or procedure completion, although the required times for cannulation and procedure completion were significantly shorter in PBCS. The incidence of adverse events was significantly higher in BAE (19.0%) than in PBCS (4.8%; P < 0.001). CONCLUSIONS: In patients with surgically altered anatomy, PBCS-ERCP showed promising results with shorter time to reach, cannulate, and a lower incidence of adverse events compared with BAE-ERCP. The success rate of reaching was favorable through PBCS compared with BAE. CLINICAL TRIAL REGISTRATION: UMIN000045546. - 非切除十二指腸乳頭部癌症例における胆管ステント機能不全の危険因子解析 多施設共同後方視的観察研究
杉浦 諒; 桑谷 将城; 金 俊文; 松本 隆祐; 池田 裕貴; 佐野 逸紀; 平田 幸司; 吉田 真誠; 柾木 喜晴; 小野 道洋; 平田 甫; 大和 弘明; 小野寺 学; 中村 英明; 多谷 容子; 江平 宣起; 中島 正人; 潟沼 朗生; Hokkaido Interventional EUS ERCP study(HONEST) group
Gastroenterological Endoscopy, 65, Suppl.2, 1993, 1993, (一社)日本消化器内視鏡学会, Oct. 2023
Japanese - Metabolomics of Duodenal Juice for Biliary Tract Cancer Diagnosis
Kazuma Kishi; Masaki Kuwatani; Yuki Ohnishi; Yasuhiro Kumaki; Hiroyuki Kumeta; Hajime Hirata; Yunosuke Takishin; Ryutaro Furukawa; Kosuke Nagai; Hiroki Yonemura; Shunichiro Nozawa; Ryo Sugiura; Kazumichi Kawakubo; Tomoyasu Aizawa; Naoya Sakamoto
Cancers, 15, 17, 4370, 4370, MDPI AG, 01 Sep. 2023
Scientific journal, The poor prognosis of malignant biliary diseases is partially caused by their difficult early diagnosis. Therefore, many patients are only diagnosed at advanced stages. This study aimed to improve diagnosis by clarifying the differences in the duodenal juice metabolomes of benign and malignant biliary diseases. From October 2021 to January 2023, duodenal juice was obtained from 67 patients with suspected biliary diseases who required endoscopic ultrasonography and endoscopic retrograde cholangiography for diagnosis/treatment. The samples metabolomes were analyzed via nuclear magnet resonance spectroscopy using an 800-MHz spectrometer. Metabolomes of malignant and benign diseases were then compared, and multivariate analysis was performed to determine the relevant factors for malignancy/benignancy. For benignancy, no significant predictors were observed. For malignancy, acetone was a significant predictor, with higher concentrations in the malignant group than in the benign group. Regarding the receiver operating characteristic curve analysis for biliary tract carcinoma diagnosis, the predictive value of acetone in duodenal juice was comparable with serum CA19-9 levels (area under the curve: 0.7330 vs. 0.691, p = 0.697). In conclusion, duodenal juice metabolomics is a feasible method that is available for differential diagnosis in the biliary disease field. - Promising Highly Targeted Therapies for Cholangiocarcinoma: A Review and Future Perspectives.
Masaki Kuwatani; Naoya Sakamoto
Cancers, 15, 14, 20 Jul. 2023, [International Magazine]
English, Scientific journal, To overcome the poor prognosis of cholangiocarcinoma (CCA), highly targeted therapies, such as antibody-drug conjugates (ADCs), photodynamic therapy (PDT) with/without systemic chemotherapy, and experimental photoimmunotherapy (PIT), have been developed. Three preclinical trials have investigated the use of ADCs targeting specific antigens, namely HER2, MUC1, and glypican-1 (GPC1), for CCA. Trastuzumab emtansine demonstrated higher antiproliferative activity in CCA cells expressing higher levels of HER2. Similarly, "staphylococcal enterotoxin A-MUC1 antibody" and "anti-GPC1 antibody-monomethyl auristatin F" conjugates showed anticancer activity. PDT is effective in areas where appropriate photosensitizers and light coexist. Its mechanism involves photosensitizer excitation and subsequent reactive oxygen species production in cancer cells upon irradiation. Hematoporphyrin derivatives, temoporfin, phthalocyanine-4, talaporfin, and chlorine e6 derivatives have mainly been used clinically and preclinically in bile duct cancer. Currently, new forms of photosensitizers with nanotechnology and novel irradiation catheters are being developed. PIT is the most novel anti-cancer therapy developed in 2011 that selectively kills targeted cancer cells using a unique photosensitizer called "IR700" conjugated with an antibody specific for cancer cells. PIT is currently in the early stages of development for identifying appropriate CCA cell targets and irradiation devices. Future human and artificial intelligence collaboration has potential for overcoming challenges related to identifying universal CCA cell targets. This could pave the way for highly targeted therapies for CCA, such as ADC, PDT, and PIT. - WONDER-01: immediate necrosectomy vs. drainage-oriented step-up approach after endoscopic ultrasound-guided drainage of walled-off necrosis-study protocol for a multicentre randomised controlled trial.
Tatsuya Sato; Tomotaka Saito; Mamoru Takenaka; Takuji Iwashita; Hideyuki Shiomi; Toshio Fujisawa; Nobuhiko Hayashi; Keisuke Iwata; Akinori Maruta; Tsuyoshi Mukai; Atsuhiro Masuda; Saburo Matsubara; Tsuyoshi Hamada; Tadahisa Inoue; Hiroshi Ohyama; Masaki Kuwatani; Hideki Kamada; Shinichi Hashimoto; Toshiyasu Shiratori; Reiko Yamada; Hirofumi Kogure; Takeshi Ogura; Kazunari Nakahara; Shinpei Doi; Kenji Chinen; Hiroyuki Isayama; Ichiro Yasuda; Yousuke Nakai
Trials, 24, 1, 352, 352, 24 May 2023, [International Magazine]
English, Scientific journal, BACKGROUND: With the increasing popularity of endoscopic ultrasound (EUS)-guided transmural interventions, walled-off necrosis (WON) of the pancreas is increasingly managed via non-surgical endoscopic interventions. However, there has been an ongoing debate over the appropriate treatment strategy following the initial EUS-guided drainage. Direct endoscopic necrosectomy (DEN) removes intracavity necrotic tissue, potentially facilitating early resolution of the WON, but may associate with a high rate of adverse events. Given the increasing safety of DEN, we hypothesised that immediate DEN following EUS-guided drainage of WON might shorten the time to WON resolution compared to the drainage-oriented step-up approach. METHODS: The WONDER-01 trial is a multicentre, open-label, superiority, randomised controlled trial, which will enrol WON patients aged ≥ 18 years requiring EUS-guided treatment in 23 centres in Japan. This trial plans to enrol 70 patients who will be randomised at a 1:1 ratio to receive either the immediate DEN or drainage-oriented step-up approach (35 patients per arm). In the immediate DEN group, DEN will be initiated during (or within 72 h of) the EUS-guided drainage session. In the step-up approach group, drainage-based step-up treatment with on-demand DEN will be considered after 72-96 h observation. The primary endpoint is time to clinical success, which is defined as a decrease in a WON size to ≤ 3 cm and an improvement of inflammatory markers (i.e. body temperature, white blood cell count, and C-reactive protein). Secondary endpoints include technical success, adverse events including mortality, and recurrence of the WON. DISCUSSION: The WONDER-01 trial will investigate the efficacy and safety of immediate DEN compared to the step-up approach for WON patients receiving EUS-guided treatment. The findings will help us to establish new treatment standards for patients with symptomatic WON. TRIAL REGISTRATION: ClinicalTrials.gov NCT05451901, registered on 11 July 2022. UMIN000048310, registered on 7 July 2022. jRCT1032220055, registered on 1 May 2022. - Significance of Shear Wave Dispersion Slope Values Before Versus After Biliary Drainage in Patients With Obstructive Jaundice
Ryo Sugiura; Masaki Kuwatani; Mutsumi Nishida; Megumi Satoh; Kazumichi Kawakubo; Shin Kato; Koji Hirata; Masahito Nakajima; Hajime Hirata; Yunosuke Takishin; Naoya Sakamoto
Ultrasound Quarterly, Publish Ahead of Print, Ovid Technologies (Wolters Kluwer Health), 22 May 2023
Scientific journal - Clinical significance of dispersion imaging by shear wave elastography in the treatment and diagnosis of pancreatic cancer.
Yunosuke Takishin; Masaki Kuwatani; Mutsumi Nishida; Tomoko Mitsuhashi; Kazuma Kishi; Kosuke Nagai; Ryutaro Furukawa; Hajime Hirata; Koji Hirata; Shin Kato; Kazumichi Kawakubo; Naoya Sakamoto
Journal of gastroenterology and hepatology, 38, 4, 656, 663, Apr. 2023, [International Magazine]
English, Scientific journal, BACKGROUND AND AIM: Recently, dispersion imaging by shear wave elastography has been developed to visualize a tissue viscosity-related factor by measuring the dispersion slope. However, clinical significance of dispersion imaging in the field of pancreatic cancer is unknown. This study aimed to investigate the clinical significance of dispersion imaging in the treatment and diagnosis of pancreatic cancer. METHODS: We measured shear wave dispersion slope (SWD) (m/s/kHz) and shear wave elasticity (SWE) (kPa) in patients with pancreatic ductal adenocarcinoma (PDA). The primary endpoint was the relationship between the changes in SWD and SWE values before and after chemotherapy and the response to chemotherapy. Secondary endpoints included SWD and SWE values in relation to differences between PDA and non-PDA sites and histopathological scores of stroma, inflammation, fibrosis, and necrosis in endoscopic ultrasound-guided fine-needle aspiration specimens. RESULTS: Fifty-six patients were included, 30 of whom underwent chemotherapy. There was no relationship between the changes of SWD and SWE values and chemotherapy responses. In 56 patients, the median SWD value was 12.20 m/s/kHz (interquartile range [IQR]: 10.88-13.61) at PDA sites and 13.57 m/s/kHz (IQR: 12.28-16.20) at non-PDA sites (P = 0.005). The median SWE value was 8.18 kPa (IQR: 7.00-9.74) at PDA sites and 6.14 kPa (IQR: 5.40-6.77) at non-PDA sites (P < 0.001). Histopathological evaluation revealed that inflammation scores were correlated with SWD values (rs = 0.42, P < 0.001). CONCLUSIONS: Dispersion imaging in pancreatic cancer would be useful for diagnosis and assessing inflammation. - Temporary rescue hemostasis for arterial hemorrhage using pentapod forceps during direct endoscopic necrosectomy.
Ryo Sugiura; Kazuma Kishi; Masaki Kuwatani
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 16 Mar. 2023, [International Magazine]
English - Suprapapillary placement of plastic versus metal stents for malignant biliary hilar obstructions: A multicenter randomized trial.
Yoshihide Kanno; Kei Ito; Kazunari Nakahara; Shinya Kawaguchi; Yoshiharu Masaki; Toru Okuzono; Hironari Kato; Masaki Kuwatani; Shotaro Ishii; Toji Murabayashi; Sho Hasegawa; Masatsugu Nagahama; Yuji Iwashita; Yosuke Michikawa; Shuzo Terada; Yujiro Kawakami; Yuki Fujii; Kazumichi Kawakubo
Gastrointestinal endoscopy, 10 Mar. 2023, [International Magazine]
English, Scientific journal, BACKGROUND AND AIMS: The efficacy of the suprapapillary placement of inside plastic stents (iPSs) for unresectable malignant hilar biliary obstructions (MHOs) has been unknown in comparison with that of inside uncovered metal stents (iMSs). This randomized controlled trial was designed to evaluate the outcomes of endoscopic placement of these stents for unresectable MHOs. METHODS: This was an open-label, randomized study at 12 Japanese institutions. The enrolled patients with unresectable MHOs were allocated to iPS and iMS groups. The primary outcome was defined as the time to recurrent biliary obstruction (RBO) in patients for whom the intervention was both technically and clinically successful. RESULTS: Among 87 enrollments, 38 in the iPS group and 46 in the iMS group were analyzed. The technical success rates were 100% (38) and 96.6% (44/46), respectively (p = 1.00). After transferring 1 unsuccessful iMS-group patient to the iPS group, since iPSs were deployed, the clinical success rates were 90.0% (35/39) for the iPS group and 88.9% (40/45) for the iMS group from a per-protocol analysis (p = 1.00). Among the patients with clinical successes, the median times to RBO were 250 (95% confidence interval [CI], 85-415) and 361 (107-615) days, respectively (p = 0.34; log-rank test). No differences were detected in rates of adverse events. CONCLUSIONS: This phase II randomized trial did not demonstrate any statistically significant difference in stent patency between suprapapillary plastic vs. metal stents. Considering the potential advantages of plastic stents for malignant hilar obstruction, these findings suggest that suprapapillary plastic stents could represent a viable alternative to metal stents for this condition. - Novel usage of one nasobiliary drainage tube for cholecystitis with cholangitis from external to internal drainage.
Kazuma Kishi; Masaki Kuwatani; Naoya Sakamoto
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 20 Feb. 2023, [International Magazine]
English, Scientific journal - Gastrointestinal: Repeated acute pancreatitis and peripancreatic fluid collection caused by pancreatic intraepithelial lesion
H Hirata; M Kuwatani; T Mitsuhashi
Journal of Gastroenterology and Hepatology, Feb. 2023
Scientific journal - A rare case of pancreatic acinar cell carcinoma presenting a submucosal tumor
Ryo Sugiura; Hidetoshi Kagaya; Hideaki Nakamura; Shoichi Horita; Takashi Meguro; Kiyotaka Sasaki; Tatsuya Yoshida; Hironori Aoki; Masaki Kuwatani; Masayuki Fukushima; Takayuki Morita; Miyoshi Fujita; Keisuke Okamura; Eiji Tamoto; Takashi Ueno; Akio Tsutaho; Ayano Inoue; Toshiyuki Takahashi
Endoscopic Ultrasound, 12, 2, 300, 300, Medknow, 2023
Scientific journal - Genetic Analyses of Cell-Free DNA in Pancreatic Juice or Bile for Diagnosing Pancreatic Duct and Biliary Tract Strictures
Kosuke Nagai; Masaki Kuwatani; Koji Hirata; Goki Suda; Hajime Hirata; Yunosuke Takishin; Ryutaro Furukawa; Kazuma Kishi; Hiroki Yonemura; Shunichiro Nozawa; Ryo Sugiura; Kazumichi Kawakubo; Naoya Sakamoto
Diagnostics, 12, 11, 2704, 2704, MDPI AG, 05 Nov. 2022
Scientific journal, Poor prognosis of pancreaticobiliary malignancies is attributed to intrinsic biological aggressiveness and the lack of reliable methods for early diagnosis. This study aimed to evaluate the feasibility and availability of pancreatic juice- and bile-derived cell-free DNA (cfDNA) for diagnosing pancreaticobiliary strictures. From October 2020 to February 2022, pancreatic juice or bile was obtained from 50 patients with pancreaticobiliary strictures during endoscopic retrograde cholangiopancreatography. cfDNAs extracted from the samples were analyzed using next-generation sequencing and a cancer gene panel. The obtained cfDNAs, genetic data and clinical information were analyzed for diagnosis. cfDNA concentrations in pancreatic juice were higher in the intraductal papillary mucinous neoplasm group than in the other groups, whereas those in bile were similar in all groups. In pancreatic juice, the sensitivity, specificity and positive and negative predictive values of cfDNA analyses were 33%, 100%, 100% and 71.4%, respectively, whereas those of cytological analyses were 0%, 100%, 0% and 62.5%, respectively. In bile, those of cell-free DNA analyses were 53%, 75%, 89.5% and 28.6%, respectively, whereas those of cytological analyses were 19%, 100%, 100% and 16%, respectively. In conclusion, pancreatic juice- and bile-derived cfDNA is a novel liquid biopsy tool that can diagnose pancreaticobiliary strictures. - Pathological and molecular diagnoses of early cancer with bile and pancreatic juice
Masaki Kuwatani; Naoya Sakamoto
Digestive Endoscopy, Nov. 2022
Scientific journal - 術後再建腸管例に対する受動彎曲機能付大腸内視鏡を用いた胆道および胆管結石処置の有用性
加藤 新; 甲谷 理紗子; 村井 太一; 板谷 一史; 池 祐太; 出水 孝章; 遠藤 文菜; 小野 雄司; 中村 路夫; 西川 秀司; 桑谷 将城
Gastroenterological Endoscopy, 64, Suppl.2, 2141, 2141, (一社)日本消化器内視鏡学会, Oct. 2022
Japanese - 術後再建腸管に対する受動彎曲機能付大腸内視鏡を用いたERCPの有用性
加藤 新; 野村 朝子; 松村 まり子; 村井 太一; 板谷 一史; 小池 祐太; 出水 孝章; 遠藤 文菜; 小野 雄司; 中村 路夫; 西川 秀司; 桑谷 将城
日本消化器病学会北海道支部例会・日本消化器内視鏡学会北海道支部例会プログラム・抄録集, 131回・125回, 41, 41, 日本消化器病学会-北海道支部, Sep. 2022
Japanese - 内科・外科による消化器病共同診療の現況と展望 当科における切除可能境界膵癌に対する術前治療の現状
原田 一顕; 中村 赳晶; 渡辺 亮介; 山村 貴洋; 川本 泰之; 結城 敏志; 桑谷 将城; 田口 大志; 加藤 徳雄; 浅野 賢道; 中村 透; 平野 聡; 小松 嘉人; 坂本 直哉
日本消化器病学会北海道支部例会・日本消化器内視鏡学会北海道支部例会プログラム・抄録集, 131回・125回, 28, 28, 日本消化器病学会-北海道支部, Sep. 2022
Japanese - Assessment of postoperative common bile duct stones after endoscopic extraction and subsequent cholecystectomy
Ryo Sugiura; Hideaki Nakamura; Shoichi Horita; Takashi Meguro; Kiyotaka Sasaki; Hidetoshi Kagaya; Tatsuya Yoshida; Hironori Aoki; Takayuki Morita; Miyoshi Fujita; Eiji Tamoto; Masayuki Fukushima; Yoshitomo Ashitate; Takashi Ueno; Akio Tsutaho; Masaki Kuwatani; Naoya Sakamoto
Surgical Endoscopy, 36, 9, 6535, 6542, Springer Science and Business Media LLC, Sep. 2022
Scientific journal - Analysis of the Pancreatic Cancer Microbiome Using Endoscopic Ultrasound–Guided Fine-Needle Aspiration–Derived Samples
Shintaro Nakano; Yasuyuki Kawamoto; Yoshito Komatsu; Rika Saito; Ken Ito; Takahiro Yamamura; Kazuaki Harada; Satoshi Yuki; Kazumichi Kawakubo; Ryo Sugiura; Shin Kato; Koji Hirata; Hajime Hirata; Masahito Nakajima; Ryutaro Furukawa; Yunosuke Takishin; Kousuke Nagai; Isao Yokota; Keisuke H. Ota; Shinji Nakaoka; Masaki Kuwatani; Naoya Sakamoto
Pancreas, Publish Ahead of Print, 4, 351, 357, Ovid Technologies (Wolters Kluwer Health), 13 Jun. 2022
Scientific journal - Needle tract seeding after endoscopic ultrasound-guided tissue acquisition of pancreatic tumors: A nationwide survey in Japan.
Masayuki Kitano; Makoto Yoshida; Reiko Ashida; Emiri Kita; Akio Katanuma; Takao Itoi; Rintaro Mikata; Kenichiro Nishikawa; Hiroyuki Matsubayashi; Yukiko Takayama; Hironari Kato; Mamoru Takenaka; Toru Ueki; Yohei Kawashima; Yousuke Nakai; Shinichi Hashimoto; Minoru Shigekawa; Hiroko Nebiki; Hidetaka Tsumura; Yosinobu Okabe; Shomei Ryozawa; Yoshiyuki Harada; Akira Mitoro; Tamito Sasaki; Hiroaki Yasuda; Natsuki Miura; Tetsuya Ikemoto; Eisuke Ozawa; Kazuhiko Shioji; Atsushi Yamaguchi; Toru Okuzono; Ichiro Moriyama; Hiroyuki Hisai; Koichi Fujita; Takuma Goto; Nakao Shirahata; Yoshinori Iwata; Yoshihiro Okabe; Kazuo Hara; Yusuke Hashimoto; Masaki Kuwatani; Hiroyuki Isayama; Nao Fujimori; Atsushi Masamune; Keiichi Hatamaru; Toshio Shimokawa; Kazuichi Okazaki; Yoshifumi Takeyama; Hiroki Yamaue
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 66, 3, 03 May 2022, [International Magazine]
English, OBJECTIVES: Endoscopic ultrasound-guided tissue acquisition (EUS-TA) plays a crucial role in the diagnosis of pancreatic tumors. The present study aimed to investigate the current status of needle tract seeding (NTS) after EUS-TA of pancreatic tumors based on a nationwide survey in Japan. METHODS: Patients who underwent surgical resection of primary pancreatic tumors after EUS-TA performed between April 2010 and March 2018 were surveyed. The incidence rates of NTS were determined, and compared in patients with pancreatic ductal adenocarcinomas (PDACs) and other tumors, and in patients who underwent transgastric and transduodenal EUS-TA of PDACs. The detailed features and prognosis of patients with NTS were also assessed. RESULTS: A total of 12,109 patients underwent surgical resection of primary pancreatic tumors after EUS-TA. The overall incidence rate of NTS was 0.330%, and the NTS rate was significantly higher in patients with PDAC than in those with other tumors (0.409% vs. 0.071%, P=0.004). NTS was observed in 0.857% of patients who underwent transgastric EUS-TA, but in none of those who underwent transduodenal EUS-TA. Of the patients with NTS of PDACs, the median time from EUS-TA to occurrence of NTS and median patient survival were 19.3 and 44.7 months, respectively, with 97.4% of NTS located in the gastric wall and 65.8% of NTS resected. The patient survival was significantly longer in patients who underwent NTS resection than in those without NTS resection (P=0.037). CONCLUSIONS: NTS appeared only after transgastric not after transduodenal EUS-TA. Careful follow-up provides an opportunity to remove localized NTS lesions by gastrectomy. - Promising Genomic Testing for Biliary Tract Cancer Using Endoscopic Ultrasound-Guided Fine-Needle Aspiration/Biopsy Specimens.
Masaki Kuwatani; Kazumichi Kawakubo; Naoya Sakamoto
Diagnostics (Basel, Switzerland), 12, 4, 05 Apr. 2022, [International Magazine]
English, Scientific journal, The undesired prognosis of biliary tract cancer is mainly attributed to the difficult detection of cancer lesions, including intraepithelial neoplasia and no standard examination for screening. In addition, pathological diagnosis of biliary stricture, whether it is malignant or benign, is not so easy, because of difficult optimal sampling by forceps biopsy and brush cytology, although various devices and methods for pathological diagnosis have been reported. Furthermore, we have to be careful about post-endoscopic retrograde cholangiography pancreatitis when we approach the biliary tract lesion via a transpapillary route. In order to improve the diagnostic accuracy, there have been several studies that indicate the feasibility and efficacy of genomic analysis for accurate diagnosis of biliary tract cancer by using pathological specimens, including endoscopic ultrasound-guided fine-needle aspiration/biopsy (EUS-FNA/FNB) samples. For efficient and precision medicine for patients with biliary tract cancer, future diagnosis and treatment should also be based on molecular and genetic analyses. In this article, we review and summarize the past knowledge and cutting edge of genomic testing for biliary tract cancer, using EUS-FNA/FNB specimens, and indicate some ingenuities in sample processing to promote effective clinical practice and future perspectives. - 個別化医療を見据えた消化器診療の現状 超音波内視鏡下穿刺吸引法で得られた検体を用いた膵腫瘍内細菌叢の検討
中野 真太郎; 川本 泰之; 小松 嘉人; 伊藤 憲; 原田 一顕; 結城 敏志; 川久保 和道; 杉浦 諒; 加藤 新; 平田 幸司; 平田 甫; 中島 正人; 古川 龍太郎; 滝新 悠之介; 永井 孝輔; 横田 勲; 太田 圭祐; 中岡 慎治; 桑谷 将城; 坂本 直哉
日本消化器病学会北海道支部例会・日本消化器内視鏡学会北海道支部例会プログラム・抄録集, 130回・124回, 36, 36, 日本消化器病学会-北海道支部, Mar. 2022
Japanese - Endoscopic Nasobiliary Drainage Comparable with Endoscopic Biliary Stenting as a Preoperative Drainage Method for Malignant Hilar Biliary Obstruction: A Multicenter Retrospective Study
Ryo Sugiura; Masaki Kuwatani; Tsuyoshi Hayashi; Makoto Yoshida; Hideyuki Ihara; Hiroaki Yamato; Manabu Onodera; Akio Katanuma
Digestion, 103, 3, 205, 216, S. Karger AG, 2022
Scientific journal, <b><i>Introduction:</i></b> Preoperative endoscopic biliary drainage (PEBD) for malignant hilar biliary obstruction (MHBO) is widely accepted. Recent PEBD consists of endoscopic nasobiliary drainage (ENBD), conventional endoscopic biliary stenting (CEBS) with plastic stents across the papilla, and endoscopic biliary inside stenting (EBIS) with plastic stents above the papilla, while ENBD is the primary procedure in Asian countries. Thus, we aimed to compare the efficacy of ENBD with those of CEBS and EBIS as a means of PEBD for MHBO. <b><i>Methods:</i></b> We retrospectively identified patients with MHBO who underwent upfront surgery between January 2011 and December 2018 in a multicenter setting. The outcome measures were cumulative dysfunction of PEBD, risk factors for PEBD dysfunction, and adverse events. <b><i>Results:</i></b> We analyzed a total of 219 patients, comprising 163 males (74.4%); mean age, 69.7 (±7.6) years; Bismuth-Corlette (BC) classification I, II, IIIa, IIIb, and IV in 68, 49, 43, 30, and 29 patients, respectively; and diagnosis of hilar cholangiocarcinoma and gallbladder cancer in 188 and 31 patients, respectively. PEBD procedures were performed in 160 patients with ENBD, 31 patients with CEBS, and 28 patients with EBIS. PEBD dysfunction occurred in 58 patients (26.5%), and the cumulative dysfunction rates were not significantly different among PEBD methods (<i>p</i> = 0.60). Multivariate analysis showed that BC-IV was significantly associated with the occurrence of PEBD dysfunction (hazard ratio = 2.10, <i>p</i> = 0.02). The adverse event rates were not significantly different among PEBD groups (<i>p</i> = 0.70). <b><i>Conclusion:</i></b> ENBD as a means of PEBD for MHBO is comparable with CEBS and EBIS in rates of dysfunction and adverse events. - 再発胆道癌に対する積極的外科切除の成績
野路 武寛; 松井 あや; 田中 公貴; 中西 喜嗣; 渡邉 祐介; 浅野 賢道; 海老原 裕磨; 倉島 庸; 中村 透; 村上 壮一; 土川 貴裕; 岡村 圭佑; 七戸 俊明; 川本 泰之; 桑谷 将城; 平野 聡
日本消化器外科学会雑誌, 54, Suppl.2, 155, 155, (一社)日本消化器外科学会, Nov. 2021
Japanese - 再発胆道癌に対する積極的外科切除の成績
野路 武寛; 松井 あや; 田中 公貴; 中西 喜嗣; 渡邉 祐介; 浅野 賢道; 海老原 裕磨; 倉島 庸; 中村 透; 村上 壮一; 土川 貴裕; 岡村 圭佑; 七戸 俊明; 川本 泰之; 桑谷 将城; 平野 聡
日本消化器外科学会雑誌, 54, Suppl.2, 155, 155, (一社)日本消化器外科学会, Nov. 2021
Japanese - Response to "Comment on Study of Risk of pancreatitis following biliary stenting with/without endoscopic sphincterotomy" by Jia-su Li et al.
Shin Kato; Masaki Kuwatani
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 12 Oct. 2021, [International Magazine]
English - Endoscopic treatment for hepaticojejunostomy anastomotic stricture: Advantages and disadvantages of balloon dilatation with stenting.
Masaki Kuwatani; Naoya Sakamoto
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 29 Sep. 2021, [International Magazine]
English - Reply.
Shin Kato; Masaki Kuwatani
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 20 Sep. 2021, [International Magazine]
English - Immunoglobulin G4-related cholecystitis mimicking gallbladder cancer diagnosed by EUS-guided biopsy.
Kosuke Nagai; Masaki Kuwatani; Yunosuke Takishin; Ryutaro Furukawa; Hajime Hirata; Kazumichi Kawakubo; Tomoko Mitsuhashi; Naoya Sakamoto
Endoscopic ultrasound, 03 Sep. 2021, [International Magazine]
English, Scientific journal - Endoscopic Papillectomy for Adenocarcinoma at the Duodenal Papilla - Will It Still Open a Pandora's Box?
Masaki Kuwatani; Naoya Sakamoto
Internal medicine (Tokyo, Japan), 60, 16, 2523, 2524, 15 Aug. 2021, [Domestic magazines]
English, Scientific journal - Risk of pancreatitis following biliary stenting with/without endoscopic sphincterotomy: A randomized controlled trial.
Shin Kato; Masaki Kuwatani; Manabu Onodera; Taiki Kudo; Itsuki Sano; Akio Katanuma; Minoru Uebayashi; Kazunori Eto; Mitsuharu Fukasawa; Shunpei Hashigo; Takuji Iwashita; Makoto Yoshida; Yoko Taya; Hiroshi Kawakami; Hironari Kato; Yousuke Nakai; Kasen Kobashigawa; Shuhei Kawahata; Susumu Shinoura; Kei Ito; Kimitoshi Kubo; Hiroaki Yamato; Kazuo Hara; Iruru Maetani; Tsuyoshi Mukai; Goro Shibukawa; Takao Itoi
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 20, 6, 1394, 1403, 12 Aug. 2021, [International Magazine]
English, Scientific journal, BACKGROUND AND AIMS: The efficacy of endoscopic sphincterotomy before endoscopic transpapillary biliary drainage in preventing post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP) has not been established. The aim of this study was to evaluate the effect of performing endoscopic sphincterotomy before biliary stent/tube placement on the occurrence of PEP. METHODS: Three-hundred seventy patients with biliary stricture requiring endoscopic biliary stenting were enrolled and randomly allocated to the endoscopic sphincterotomy group (ES group, n = 185) or non-endoscopic sphincterotomy group (non-ES group, n = 185). All participants were followed up for 30 days after the procedure. The data and occurrence of adverse events were prospectively collected. The primary outcome measure of this study was the incidence of PEP within 2 days of initial transpapillary biliary drainage. Secondary outcome measures were the incidence of other adverse events related to biliary stent/tube placement. RESULTS: PEP occurred in 36 (20.6%) patients in the non-ES group and in 7 (3.9%) patients in the ES group (P < .001). The difference in the incidence of PEP between the two groups in the per-protocol population was 16.7% (95% confidence interval, 10.1%-23.3%), which was not within the noninferiority margin of 6%. Except for bleeding, the incidences of other adverse events were not significantly different between the groups. CONCLUSION: ES before endoscopic biliary stenting could have the preventive effect on the occurrence of PEP in patients with biliary stricture.; University Hospital Medical Information Network Number, UMIN000025727. - 診断・治療に難渋した症例～round table discussion 反復する急性膵炎と膵周囲液体貯留を認めたpancreatic fistulaの1例
平田 甫; 桑谷 将城; 永井 孝輔; 瀧新 悠之介; 古川 龍太郎; 坂本 直哉; 浅野 賢道; 平野 聡; 三橋 智子
膵臓, 36, 3, A257, A257, (一社)日本膵臓学会, Aug. 2021
Japanese - Sharp recanalization and rendezvous technique for biliary occlusions due to spacious bile leak after hepatectomy.
Hajime Hirata; Masaki Kuwatani; Daisuke Abo
Journal of hepato-biliary-pancreatic sciences, 28, 8, e38-e39, Aug. 2021, [Domestic magazines]
English, Scientific journal, Highlight Hirata and colleagues report on a difficult case of biliary strictures and extensive bile leak near the hepatic hilum after hepatectomy for metastatic cancer. Treatment with sharp recanalization and the rendezvous technique was effective to establish bridging between the common bile duct and intrahepatic bile duct in this case. - Clinical and Image Characteristics of IgG4-Related Sclerosing Cholecystitis.
Masaki Kuwatani; Naoya Sakamoto
Diagnostics (Basel, Switzerland), 11, 8, 28 Jul. 2021, [International Magazine]
English, Scientific journal, Since autoimmune pancreatitis (AIP) was established as a new disease entity, sclerosing change with abundant immunoglobulin-4 (IgG4)-positive plasma cells, storiform fibrosis, and obliterative phlebitis are main pathological features in IgG4-related diseases. Regarding IgG4-related sclerosing cholecystitis (IgG4-CC), which is occasionally associated with AIP cases and is rarely isolated, there are no diagnostic criteria and insufficient perceptions of the image findings. Although there have been some reports on IgG4-CC, differentiation between IgG4-CC and gallbladder cancer is very difficult in some cases with a localized lesion. In this review, we especially focused on image findings of IgG4-CC and summarized its image features for diagnostic assistance. The ultrasonography and CT findings of IgG4-CC could be classified into diffuse and localized types. Based on these findings, the presence of wall thickening with an intact or smooth mucosal layer, followed by a homogenously thickened outer layer, would be a helpful morphological finding to distinguish IgG4-CC from gallbladder cancer. - Study protocol for endoscopic ultrasonography-guided ethanol injection therapy for patients with pancreatic neuroendocrine neoplasm: a multicentre prospective study.
Kazuyuki Matsumoto; Hironari Kato; Masayuki Kitano; Kazuo Hara; Masaki Kuwatani; Reiko Ashida; Mamoru Takenaka; Tatsuhiro Yamazaki; Jun Sakurai; Michihiro Yoshida; Hiroyuki Okada
BMJ open, 11, 7, e046505, 12 Jul. 2021, [International Magazine]
English, Scientific journal, INTRODUCTION: The management of small pancreatic neuroendocrine neoplasms (PNENs) remains controversial. The standard treatment for PNENs is surgical resection; however, invasiveness of surgical procedure remains higher and the incidence of postoperative adverse events is still high. Recently, the efficacy and safety of endoscopic ultrasonography (EUS)-guided ethanol injection for small PNENs has been preliminarily demonstrated. Thus, a multicentre prospective study is being conducted to evaluate the efficacy and safety of EUS-guided ethanol injection therapy for small PNENs. METHODS AND ANALYSIS: The major eligibility criteria are the presence of pathologically diagnosed grade (G) 1 tumour, a tumour size of ≤15 mm and non-functional PNEN or insulinoma. For treatment, we will use a 25-gauge needle and pure ethanol. Contrast-enhanced CT (CE-CT) will be performed on postoperative day 3-5, and if enhanced areas of the tumour are still apparent, an additional session is scheduled during the same hospitalisation period. We set the total amount of ethanol per session to 2 mL. To evaluate the efficacy and safety, CE-CT will be performed at 1 and 6 months after treatment. The primary endpoint is the percentage of subjects who achieved all of the following evaluated points. Efficacy will be evaluated based on the achievement of complete ablation (defined as no enhanced area within the tumour on CE-CT) at 1 and 6 months. Safety will be evaluated based on the avoidance of severe adverse events within 1 month after treatment, continuing severe pancreatic fistula at 1 month after treatment and the incidence and/or exacerbation of diabetes mellitus at 6 months after treatment. ETHICS AND DISSEMINATION: This protocol has been approved by Okayama University Certified Review Board (approval number. CRB19-007). The results will be submitted to peer-reviewed journals and will be presented at international conferences. TRIAL REGISTRATION NUMBER: jRCTs061200016. - Trial protocol: a randomised controlled trial to verify the non-inferiority of a partially covered self-expandable metal stent to an uncovered self-expandable metal stent for biliary drainage during neoadjuvant therapy in patients with pancreatic cancer with obstructive jaundice (PUN-NAC trial).
Masaki Kuwatani; Kazumichi Kawakubo; Kazuya Sugimori; Hiroyuki Inoue; Hideki Kamada; Hirotoshi Ishiwatari; Shin Kato; Takuji Iwashita; Makoto Yoshida; Shinichi Hashimoto; Masahiro Itonaga; Yusuke Mizukami; Yusuke Nomura; Akio Katanuma; Naoya Sakamoto
BMJ open, 11, 7, e045698, 08 Jul. 2021, [International Magazine]
English, Scientific journal, INTRODUCTION: Neoadjuvant chemotherapy or neoadjuvant chemoradiotherapy (NAC/NACRT) for resectable/borderline resectable pancreatic cancers was recently performed to improve clinical outcomes and led to good results, although it remains controversial whether NAC/NACRT is beneficial for resectable pancreatic cancer. A few recent studies revealed longer patency and lower cost related to the stent occlusion of a metal stent than those of a plastic stent during NAC/NACRT. It also remains controversial which type of self-expandable metal stent (SEMS) is the most suitable for patients with resectable/borderline resectable pancreatic cancer during NAC/NACRT: an uncovered SEMS (USEMS), a fully covered SEMS (FCSEMS) or a partially covered SEMS (PCSEMS). So far, two randomised controlled trials indicated that a USEMS and an FCSEMS were similar in preoperative stent dysfunction and adverse event rate. Thus, we aimed to verify the non-inferiority of a PCSEMS to a USEMS in this multicentre randomised controlled trial. METHODS AND ANALYSIS: We designed a multicentre randomised controlled trial, for which we will recruit 100 patients with resectable/borderline resectable pancreatic cancer and distal biliary obstruction scheduled for NAC/NACRT from 13 high-volume institutions. Patients will be randomly allocated to the PCSEMS group or USEMS group. The primary outcome measure is the preoperative biliary event rate. Data will be analysed after completion of the study. We will calculate the 95% CIs of the incidence of preoperative biliary events in each group and analyse whether the difference between them is within the non-inferiority margin (10%). ETHICS AND DISSEMINATION: This study has been approved by the institutional review board of Hokkaido University Hospital. The results will be submitted for presentation at an international medical conference and published in a peer-reviewed journal. TRIAL REGISTRATION NUMBER: UMIN000041737; jRCT1012200002. - Possible reasons for the regrettable results of patency of an inside stent in endoscopic transpapillary biliary stenting.
Masaki Kuwatani; Kazumichi Kawakubo; Naoya Sakamoto
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 04 May 2021, [International Magazine]
English, Scientific journal, Endoscopic biliary decompression is a minimally invasive procedure for cholestasis since the first endoscopic retrograde cholangiopancreatography-guided biliary stenting performed by Soehendra and Reynders-Frederix. Among the endoscopic biliary decompression, endoscopic transpapillary biliary stenting (EBS), is a mainstream choice and presently has two methods of placement: stenting above the sphincter of Oddi (SO) (suprapapillary) and stenting across the SO (transpapillary). Stent patency is the most important concern for patients, endoscopists and physicians because it can affect both the life prognosis and treatment schedule of patients. Biliary stent occlusion can occur because of several factors. Among them, direct food impaction, biofilm formation, and sludge formation play important roles and are presumed to be theoretically overcome by EBS above the SO. Thus, EBS above the SO is expected to result in a longer patency than EBS across the SO. In the literature, there have been six comparative studies on EBS for distal biliary obstruction in which the stent was placed above or across the SO, including two randomized controlled trials (RCTs) with negative results of stenting above the SO. With respect to EBS for hilar biliary obstruction, there have been no RCTs, whereas four retrospective comparative studies with negative results and four retrospective comparative studies showing positive results of stenting above the SO have been reported. In this review, we focused on EBS above and across the SO, and summarized the positive and negative results of the two types of stenting to promote effective clinical practice and to provide a basis for future studies. - 腫瘍の一部が胆管内腫瘍栓様発育を呈した浸潤型肝門部胆管癌
野路 武寛; 松井 あや; 桑谷 将城; 大場 光信; 三橋 智子; 平野 聡
胆道, 35, 2, 230, 236, (一社)日本胆道学会, May 2021
Japanese - Advanced perihilar cholangiocarcinoma with partial thrombus like lesion
Noji Takehiro; Matsui Aya; Kuwatani Masaki; Ohba Mitsunobu; Mitsuhashi Tomoko; Hirano Satoshi
Tando, 35, 2, 230, 236, Japan Biliary Association, May 2021
Japanese - Spiral stent placement for bile leakage after hepatobiliary surgery.
Yunosuke Takishin; Masaki Kuwatani; Naoya Sakamoto
Endoscopy, 28 Apr. 2021, [International Magazine]
English, Scientific journal - Asymptomatic Choledocholithiasis that Causes a Dilemma between Treatment and Observation.
Masaki Kuwatani; Naoya Sakamoto
JMA journal, 4, 2, 176, 177, 15 Apr. 2021, [Domestic magazines]
English - Endoscopic ultrasonography-guided pancreaticoduodenostomy with a lumen-apposing metal stent to treat main pancreatic duct dilatation.
Masaki Kuwatani; Kosuke Nagai; Yunosuke Takishin; Ryutaro Furukawa; Hajime Hirata; Kazumichi Kawakubo; Naoya Sakamoto
Endoscopy, 30 Mar. 2021, [International Magazine]
English, Scientific journal - Efficacy of a novel ultra-sharp dilation device for dilating bare metal stent mesh in patients with hilar malignant biliary obstruction.
Shin Kato; Masaki Kuwatani; Kazumichi Kawakubo; Ryutaro Furukawa; Koji Hirata; Yunosuke Takishin; Hajime Hirata; Naoya Sakamoto
Scandinavian journal of gastroenterology, 56, 3, 1, 4, 09 Feb. 2021, [International Magazine]
English, Scientific journal, The placement of additional stents in patients with hilar malignant biliary obstruction can be challenging when a metal stent already exists because occasionally, the catheter and delivery system of the additional stent cannot pass through the mesh of the formerly placed stent. We studied ten consecutive patients with hilar malignant biliary obstruction who underwent mesh dilation using a novel ultra-sharp dilation device (ES dilator) to assess the efficacy and safety of the ES dilator for mesh dilation. Mesh dilation using the ES dilator was successful in eight patients (8/10; 80.0%), which was the same rate as that of patients with pre-dilation using a Soehendra biliary dilation catheter (4/5, 80.0%) and patients without pre-dilation (4/5, 80.0%). In the two patients with dilation failure, the angle of the hilar bile duct branch was too steep to permit the passage of a stiff dilation device. Nonetheless, stent placement was uncomplicated in all mesh-dilated patients (8/8, 100.0%), and no adverse events related to the ES dilator were observed. The efficacy of an ultra-sharp dilation device appears promising for metallic stent mesh dilation, especially in patients where conventional methods are unsuccessful. However, additional data are necessary to confirm our findings. - Near-infrared photoimmunotherapy (NIR-PIT) on cholangiocarcinoma using a novel catheter device with light emitting diodes.
Hajime Hirata; Masaki Kuwatani; Kohei Nakajima; Yuki Kodama; Yasuo Yoshikawa; Mikako Ogawa; Naoya Sakamoto
Cancer science, 112, 2, 828, 838, Feb. 2021, [International Magazine]
English, Scientific journal, Near-infrared photoimmunotherapy (NIR-PIT) is a novel therapy for cancers that uses NIR light and antibody-photosensitizer (IR700) conjugates. However, it is difficult to deliver NIR light into the bile duct for cholangiocarcinoma (CCA) from the conventional extracorporeal apparatus. Thus, in this study, we developed a dedicated catheter with light emitting diodes (LEDs) that supersedes conventional external irradiation devices; we investigated the therapeutic effect of NIR-PIT for CCA using the novel catheter. The new catheter was designed to be placed in the bile duct and a temperature sensor was attached to the tip of the catheter to avoid thermal burn. An anti-epidermal growth factor receptor (EGFR) antibody, Panitumumab-IR700 conjugate or anti-human epidermal growth factor receptor type 2 (HER2) antibody, Trastuzumab-IR700 conjugate, was used with EGFR- or HER2-expressing cell lines, respectively. The in vitro efficacy of NIR-PIT was confirmed in cultured cells; the capability of the new catheter for NIR-PIT was then tested in a mouse tumor model. NIR-PIT via the developed catheter treated CCA xenografts in mice. NIR-PIT had an effect in Panitumumab-IR700 conjugate- and Trastuzumab-IR700 conjugate-treated CCA cells that depended on the receptor expression level. Tumor growth was significantly suppressed in mice treated with NIR-PIT using the novel catheter compared with controls (P < .01). NIR-PIT was an effective treatment for EGFR- and HER2-expressing CCA cells, and the novel catheter with mounted LEDs was useful for NIR-PIT of CCA. - A drainage strategy for postoperative pancreatic fistula after left-sided pancreatectomy based on the wall status of collected fluid.
Masaki Kuwatani; Masafumi Imamura; Tsuyoshi Hayashi; Makoto Yoshida; Yasutoshi Kimura; Toshimichi Asano; Toru Nakamura; Masayo Motoya; Makoto Yoshida; Takehiro Noji; Keisuke Okamura; Kuniyuki Takahashi; Akio Katanuma; Satoshi Hirano
Langenbeck's archives of surgery, 406, 3, 743, 751, 03 Jan. 2021, [International Magazine]
English, Scientific journal, PURPOSE: Postoperative pancreatic fistula (POPF) after pancreatectomy is one of the severe postoperative adverse events. We aimed to clarify the outcomes of a strategy for POPF after left-sided pancreatectomy with one-step endoscopic ultrasonography-guided drainage (EUSD) and percutaneous drainage (PCD) based on the wall status of collected fluid. METHODS: From January 2012 to September 2017, 90 of 336 patients developed grade B/C POPF and were retrospectively analyzed. Primary outcome measures were the technical and clinical success and resolution rates. Secondary outcome measures were time from surgery to intervention, and time from intervention to discharge/resolution or stent/tube removal and adverse events. RESULTS: Seventeen patients underwent EUSD and 73 patients underwent PCD for POPF. The technical success rates were 100% in both the EUSD and PCD groups. The clinical success and resolution rates in the EUSD group were 100%, while those in the PCD group were 98.6%. The time from surgery to intervention was significantly longer in the EUSD group than in the PCD group (20 vs. 11 days, p < 0.001). The time from intervention to discharge/resolution was significantly shorter in the EUSD group than in the PCD group (11 vs. 22 days, p < 0.001/10 vs. 20 days, p < 0.001). The time from intervention to stent/tube removal was significantly shorter in the PCD group than in the EUSD group (20.5 vs. 873 days, p < 0.001). Adverse event rates were similar in the two groups (11.8% vs. 5.5%). CONCLUSION: A drainage strategy for POPF based on the wall status of collected fluid is appropriate. - Digital PCR-based plasma cell-free DNA mutation analysis for early-stage pancreatic tumor diagnosis and surveillance.
Tetsuhiro Okada; Yusuke Mizukami; Yusuke Ono; Hiroki Sato; Akihiro Hayashi; Hidemasa Kawabata; Kazuya Koizumi; Sakue Masuda; Shinichi Teshima; Kuniyuki Takahashi; Akio Katanuma; Yuko Omori; Hirotoshi Iwano; Masataka Yamada; Tomoki Yokochi; Shingo Asahara; Kazumichi Kawakubo; Masaki Kuwatani; Naoya Sakamoto; Katsuro Enomoto; Takuma Goto; Junpei Sasajima; Mikihiro Fujiya; Jun Ueda; Seiji Matsumoto; Kenzui Taniue; Ayumu Sugitani; Hidenori Karasaki; Toshikatsu Okumura
Journal of gastroenterology, 55, 12, 1183, 1193, Dec. 2020, [Domestic magazines]
English, Scientific journal, BACKGROUND: Cell-free DNA (cfDNA) shed from tumors into the circulation offers a tool for cancer detection. Here, we evaluated the feasibility of cfDNA measurement and utility of digital PCR (dPCR)-based assays, which reduce subsampling error, for diagnosing pancreatic ductal adenocarcinoma (PDA) and surveillance of intraductal papillary mucinous neoplasm (IPMN). METHODS: We collected plasma from seven institutions for cfDNA measurements. Hot-spot mutations in KRAS and GNAS in the cfDNA from patients with PDA (n = 96), undergoing surveillance for IPMN (n = 112), and normal controls (n = 76) were evaluated using pre-amplification dPCR. RESULTS: Upon Qubit measurement and copy number assessment of hemoglobin-subunit (HBB) and mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 (MT-ND1) in plasma cfDNA, HBB offered the best resolution between patients with PDA relative to healthy subjects [area under the curve (AUC) 0.862], whereas MT-ND1 revealed significant differences between IPMN and controls (AUC 0.851). DPCR utilizing pre-amplification cfDNA afforded accurate tumor-derived mutant KRAS detection in plasma in resectable PDA (AUC 0.861-0.876) and improved post-resection recurrence prediction [hazard ratio (HR) 3.179, 95% confidence interval (CI) 1.025-9.859] over that for the marker CA19-9 (HR 1.464; 95% CI 0.674-3.181). Capturing KRAS and GNAS could also provide genetic evidence in patients with IPMN-associated PDA and undergoing pancreatic surveillance. CONCLUSIONS: Plasma cfDNA quantification by distinct measurements is useful to predict tumor burden. Through appropriate methods, dPCR-mediated mutation detection in patients with localized PDA and IPMN likely to progress to invasive carcinoma is feasible and complements conventional biomarkers. - A case with eosinophilic cholangitis which presented the unique cholangioscopic findings.
Hajime Hirata; Masaki Kuwatani; Tomoko Mitsuhashi
Journal of hepato-biliary-pancreatic sciences, 11 Nov. 2020, [Domestic magazines]
English, Scientific journal - Conversion surgery for initially unresectable biliary malignancies: a multicenter retrospective cohort study.
Takehiro Noji; Minoru Nagayama; Koji Imai; Yasuyuki Kawamoto; Masaki Kuwatani; Masafumi Imamura; Keikuke Okamura; Yastoshi Kimura; Satoshi Hirano
Surgery today, 50, 11, 1409, 1417, Nov. 2020, [Domestic magazines]
English, Scientific journal, PURPOSE: Few studies have focused on conversion surgery for biliary malignancy; thus, it is not clear if this treatment modality can extend the survival of patients with unresectable biliary malignancy. We conducted a multicenter retrospective cohort study to evaluate the surgical outcomes of conversion surgery in this setting and analyze long-term survival. METHODS: We collected clinical data retrospectively on patients who underwent conversion surgery for biliary malignancy. RESULTS: Twenty-four patients met our inclusion criteria. Preoperative chemotherapy regimens or chemoradiation therapy regimens were administered based on the institutional criteria, and surgical procedures were chosen based on tumor location. Morbidity occurred in 16 patients (66.7%), and 1 patient died of liver failure after surgery. The overall 5-year survival rate following initial therapy was 43.2%, and the median survival time was 57.4 months. The corresponding values following surgery were 38.2% and 34.3 months, respectively. The 5-year survival rate of the 24 patients who received both chemotherapy and surgery was significantly better than that of 110 patients treated with chemotherapy only (p < 0.001). CONCLUSION: Conversion surgery for initially unresectable biliary malignancies may be feasible and achieve long-term survival for selected patients. - Angiogenic Dreaded Killer- Cholesterol Crystal Embolization.
Masaki Kuwatani; Naoya Sakamoto
Internal medicine (Tokyo, Japan), 60, 6, 825, 826, 14 Oct. 2020, [Domestic magazines]
English, Scientific journal - 主膵管多発狭窄を呈した膵管上皮内病変の1例
佐々木 貴志; 桑谷 将城; 三橋 智子; 浅野 賢道; 中村 透; 平野 聡; 坂本 直哉
日本消化器病学会北海道支部例会・日本消化器内視鏡学会北海道支部例会プログラム・抄録集, 127回・121回, 68, 68, 日本消化器病学会-北海道支部, Oct. 2020
Japanese - 超音波内視鏡下瘻孔形成術における先端鋭拡張専用カテーテルと通電拡張カテーテルの有用性の比較
加藤 新; 桑谷 将城; 平田 甫; 瀧新 悠之介; 平田 幸司; 古川 龍太郎; 坂本 直哉
Gastroenterological Endoscopy, 62, Suppl.2, 2172, 2172, (一社)日本消化器内視鏡学会, Oct. 2020
Japanese - 難渋する胆道ドレナージの工夫 肝門部胆管金属ステント留置困難症例におけるES dilatorの有用性(Eligible cases of stent-in-stent placement for malignant hilar biliary obstructions in consideration of endoscopic reintervention)
滝新 悠之介; 桑谷 将城; 坂本 直哉; 古川 龍太郎; 平田 甫; 平田 幸司; 加藤 新
胆道, 34, 3, 452, 452, 日本胆道学会, Aug. 2020
English - 乳頭膨張型胆管癌と術前診断された胆管上皮内癌の一例
古川 龍太郎; 桑谷 将城; 三橋 智子; 平田 甫; 瀧新 悠之介; 平田 幸司; 加藤 新; 平野 聡; 坂本 直哉
胆道, 34, 3, 528, 528, 日本胆道学会, Aug. 2020
Japanese - 肝門部金属ステント留置困難例でのESダイレーターを用いたトラブルシューティング
加藤 新; 桑谷 将城; 坂本 直哉; 平田 甫; 瀧新 悠之介; 平田 幸司; 古川 龍太郎
Gastroenterological Endoscopy, 62, Suppl.1, 1234, 1234, (一社)日本消化器内視鏡学会, Aug. 2020
Japanese - 膵周囲液体貯留に対する超音波内視鏡下ドレナージの有効性と安全性
古川 龍太郎; 桑谷 将城; 坂本 直哉; 平田 甫; 瀧新 悠之介; 平田 幸司; 加藤 新
Gastroenterological Endoscopy, 62, Suppl.1, 1312, 1312, (一社)日本消化器内視鏡学会, Aug. 2020
English - 慢性膵炎による主膵管高度狭窄に対する経乳頭的通電拡張術の有効性
加藤 新; 桑谷 将城; 平田 甫; 瀧新 悠之介; 平田 幸司; 古川 龍太郎; 坂本 直哉
膵臓, 35, 3, A326, A326, (一社)日本膵臓学会, Jul. 2020
Japanese - IgG4関連硬化性胆管炎の臨床的特徴とステロイド維持療法の妥当性
瀧新 悠之介; 桑谷 将城; 古川 龍太郎; 平田 甫; 平田 幸司; 加藤 新; 坂本 直哉
日本消化器病学会雑誌, 117, 臨増総会, A297, A297, (一財)日本消化器病学会, Jul. 2020
Japanese - Non-negligible rate of needle tract seeding after endoscopic ultrasound-guided fine-needle aspiration for patients undergoing distal pancreatectomy for pancreatic cancer.
Kei Yane; Masaki Kuwatani; Makoto Yoshida; Takuma Goto; Ryusuke Matsumoto; Hideyuki Ihara; Toshinori Okuda; Yoko Taya; Nobuyuki Ehira; Taiki Kudo; Takeya Adachi; Kazunori Eto; Manabu Onodera; Itsuki Sano; Masanori Nojima; Akio Katanuma
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 32, 5, 801, 811, Jul. 2020, [International Magazine]
English, Scientific journal, BACKGROUND AND AIMS: Needle tract seeding after preoperative endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) for pancreatic body and tail cancer has been reported. This study aimed to investigate the long-term outcomes, including the needle tract seeding ratio, of patients undergoing distal pancreatectomy for pancreatic body and tail cancer diagnosed preoperatively by EUS-FNA. METHODS: This retrospective, observational cohort study assessed patients from three university hospitals and 11 tertiary referral centers. All patients who underwent distal pancreatectomy for invasive cancer of the pancreatic body and tail between January 2006 and December 2015 were identified and reviewed. Needle tract seeding rate, recurrence-free survival (RFS), and overall survival (OS) were evaluated. RESULTS: Of the 301 total patients analyzed, 176 underwent preoperative EUS-FNA (EUS-FNA group) and 125 did not (non-EUS-FNA group). The median follow-up periods of the EUS-FNA group and non-EUS-FNA group were 32.8 and 30.1 months. Six patients (3.4%) in the EUS-FNA group were diagnosed as having needle tract seeding. The 5-year cumulative needle tract seeding rate estimated using Fine and Gray's method was 3.8% (95% CI 1.6-7.8%). The median RFS or OS was not significantly different between the EUS-FNA group and the non-EUS-FNA group (23.7 vs 16.9 months: P = 0.205; 48.0 vs 43.9 months: P = 0.392). CONCLUSION: Although preoperative EUS-FNA for pancreatic body and tail cancer has no negative effect on RFS or OS, needle tract seeding after EUS-FNA was observed to have a non-negligible rate. (UMIN000030719). - Risk factors for dysfunction of preoperative endoscopic biliary drainage for malignant hilar biliary obstruction.
Ryo Sugiura; Masaki Kuwatani; Shin Kato; Kazumichi Kawakubo; Hirofumi Kamachi; Akinobu Taketomi; Takehiro Noji; Keisuke Okamura; Satoshi Hirano; Naoya Sakamoto
Journal of hepato-biliary-pancreatic sciences, 27, 11, 851, 859, 07 Jun. 2020, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, BACKGROUND: Few studies have focused on the risk factors for dysfunction of endoscopic biliary drainage (EBD) in preoperative patients with malignant hilar biliary obstruction (MHBO). METHODS: We searched the database between February 2011 and December 2018 and identified patients with MHBO who underwent radical operation. The rate of dysfunction of the initial EBD, risk factors for dysfunction of the initial EBD and survival after surgery were retrospectively evaluated. RESULTS: We analyzed a total of 131 patients [95 males (72.5%); mean age, 69.5(±7.3) years; Bismuth-Corlette classification (BC) I/II/IIIa/IIIb/IV, 50/26/22/17/16; hilar cholangiocarcinoma/gall bladder cancer, 115/16]. Dysfunction of the initial EBD occurred in 28patients (21.4%). The cumulative incidences of dysfunction of the initial EBD in all patients were 18.4%, 38.2% and 47.0% at 30, 60 and 90days, respectively (Kaplan-Meier method). The rate of dysfunction of the initial EBD increased in patients with BC-IV (P=0.03). Multivariate analysis showed that BC-IV and pre-EBD cholangitis were significantly associated with the occurrence of dysfunction of the initial EBD. Survival rates were not significantly different according to the initial biliary drainage methods and presence/absence of the initial EBD dysfunction. CONCLUSIONS: Dysfunction of the initial EBD frequently occurs in patients with the BC-IV and those with pre-EBD cholangitis. - Side-by-side placement of fully covered self-expandable metal stents for malignant distal biliary obstruction.
Koji Hirata; Masaki Kuwatani; Hajime Hirata; Ryo Sugiura; Shin Kato; Naoya Sakamoto
Clinical journal of gastroenterology, 13, 3, 455, 458, Jun. 2020, [Domestic magazines]
English, Scientific journal, A covered self-expandable metal stent is an efficient and established tool for solution of biliary obstruction. The use of multiple fully covered self-expandable metal stents (SEMSs) for distal malignant biliary obstruction has never been reported. The first case, a 33-year-old female with pancreatic head cancer had low bifurcation of the hepatic ducts and developed obstructive cholangitis by the first single SEMS. The second case, a-59-year-old female with pancreatic head cancer repeatedly underwent biliary decompression by a single SEMS (10-mm, 12-mm), because placed SEMSs were repeatedly dislocated. For solving these problems, we performed side-by-side placement of covered self-expandable metal stents. Finally, side-by-side placement of SEMSs across the papilla for distal malignant biliary obstruction was feasible and available for the two cases. - Feasibility of a distal pigtail shaped stent placement above the papilla for biliary obstruction.
Koji Hirata; Masaki Kuwatani; Naoya Sakamoto
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 32, 4, e73-e74, May 2020, [International Magazine]
English, Scientific journal - Inutility of endoscopic sphincterotomy to prevent pancreatitis after biliary metal stent placement in the patients without pancreatic duct obstruction.
Shin Kato; Masaki Kuwatani; Tsuyoshi Hayashi; Kazunori Eto; Michihiro Ono; Nobuyuki Ehira; Hiroaki Yamato; Itsuki Sano; Yoko Taya; Manabu Onodera; Kimitoshi Kubo; Hideyuki Ihara; Hajime Yamazaki; Naoya Sakamoto
Scandinavian journal of gastroenterology, 55, 4, 503, 508, 10 Apr. 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal, Background: The incidence of post-ERCP pancreatitis (PEP) has been reported to be significantly higher in patients without main pancreatic duct (MPD) obstruction who undergo transpapillary biliary metal stent (MS) placement than in those with ordinary ERCP setting.Objective: To evaluate the benefit of endoscopic sphincterotomy (ES) prior to MS placement in preventing PEP in patients with distal malignant biliary obstruction (MBO) without MPD obstruction.Materials and methods: In total, 160 patients who underwent initial MS placement for MBO were enrolled. Eighty-two patients underwent ES immediately prior to MS placement, whereas 78 underwent MS placement without ES. An inverse probability of treatment weighting method was adopted to adjust the differences of the patients' characteristics. The primary outcome was the incidence of PEP. The secondary outcomes included the incidence of other adverse events (bleeding, cholangitis, perforation and stent dislocation) and time to recurrent biliary obstruction.Results: The incidence of PEP was 26.8% in the ES and 23.1% in the non-ES (unadjusted odds ratio [OR] [95%CI]: 1.22, [0.60-2.51], adjusted OR [95%CI]: 1.23, [0.53-2.81], p = .63). Logistic-regression analysis revealed no factors that could be attributed to the occurrence of PEP. The incidence of other adverse events was not different between the groups. The median time to recurrent biliary obstruction was 131 (2-465) days and 200 (4-864) days in the ES and non-ES, respectively (p = .215).Conclusions: ES prior to MS placement for patients with distal MBO without MPD obstruction does not reduce the incidence of PEP. - Clinical Outcomes of Biliary Drainage during a Neoadjuvant Therapy for Pancreatic Cancer: Metal versus Plastic Stents.
Masaki Kuwatani; Toru Nakamura; Tsuyoshi Hayashi; Yasutoshi Kimura; Michihiro Ono; Masayo Motoya; Koji Imai; Keisuke Yamakita; Takuma Goto; Kuniyuki Takahashi; Hiroyuki Maguchi; Satoshi Hirano
Gut and liver, 14, 2, 269, 273, 15 Mar. 2020, [International Magazine]
English, Scientific journal, Neoadjuvant chemotherapy/neoadjuvant chemoradiotherapy (NAC/NACRT) can be performed in patients with pancreatic cancer to improve survival. We aimed to clarify the clinical outcomes of biliary drainage with a metal stent (MS) or a plastic stent (PS) during NAC/NACRT. Between October 2013 and April 2016, 96 patients with pancreatic cancer were registered for NAC/NACRT. Of these, 29 patients who underwent biliary drainage with MS or PS before NAC/NACRT and a subsequent pancreatoduodenectomy were retrospectively analyzed with regard to patient characteristics, preoperative recurrent biliary obstruction rate, NAC/NACRT delay or discontinuation rate, and operative characteristics. The median age of the patients was 67 years. NAC and NACRT were performed in 14 and 15 patients, respectively, and MS and PS were used in 17 and 12 patients, respectively. Recurrent biliary obstruction occurred in 6% and 83% of the patients in the MS and PS groups, respectively (p<0.001). NAC/NACRT delay was observed in 35% and 50% of the patients in the MS and PS groups, respectively (p=0.680). NAC/NACRT discontinuation was observed in 12% and 17% of the patients in the MS and PS groups, respectively (p=1.000). The operative time in the MS group tended to be longer than that in the PS group (625 minutes vs 497 minutes, p=0.051), and the operative blood loss volumes and postoperative adverse event rates were not different between the two groups. MS was better than PS from the viewpoint of preventing recurrent biliary obstruction, although MS was similar to PS with regards to perioperative outcomes. - 消化器がん内視鏡診断・治療の最前線 胆嚢癌に対する術前胆道ドレナージ 肝門部領域胆管癌との比較検討
平田 幸司; 桑谷 将城; 加藤 新; 坂本 直哉
日本消化器病学会北海道支部例会プログラム・抄録集, 126回, 35, 35, 日本消化器病学会-北海道支部, Mar. 2020
Japanese - 悪性胆道狭窄に対するトリプルルーメンカテーテルの有用性
平田 甫; 桑谷 将城; 瀧新 悠之介; 古川 龍太郎; 平田 幸司; 加藤 新; 坂本 直哉
日本消化器病学会北海道支部例会プログラム・抄録集, 126回, 43, 43, 日本消化器病学会-北海道支部, Mar. 2020
Japanese - 【EUSの現状と将来】治療 胆管挿管困難例に対するRendezvous法
桑谷 将城; 川久保 和道; 加藤 新; 平田 幸司; 平田 甫; 坂本 直哉
肝胆膵, 80, 3, 471, 479, (株)アークメディア, Mar. 2020
Japanese - 【慢性膵炎診療2020】基礎研究・病態 早期慢性膵炎は慢性膵炎確診・準確診例に移行するのか
桑谷 将城; 加藤 新; 平田 幸司; 平田 甫; 坂本 直哉
肝胆膵, 80, 2, 265, 269, (株)アークメディア, Feb. 2020
Japanese - Nationwide epidemiological survey of chronic pancreatitis in Japan: introduction and validation of the new Japanese diagnostic criteria 2019
Atsushi Masamune; Kazuhiro Kikuta; Kiyoshi Kume; Shin Hamada; Ichiro Tsuji; Yoshifumi Takeyama; Tooru Shimosegawa; Kazuichi Okazaki; Shin Miura; Tetsuya Takikawa; Seiji Hongo; Eriko Nakano; Tatsuhide Nabeshima; Ryotaro Matsumoto; Yu Tanaka; Masayuki Ueno; Tsuyoshi Mukai; Masataka Matsumoto; Yasushi Kudo; Shunjiro Azuma; Kosuke Okuwaki; Satoshi Yamamoto; Kazuo Inui; Kasen Kobashigawa; Jun Unno; Nao Fujimori; Katsuya Kitamura; H. iroyuki Miyakawa; Kuniyuki Takahashi; Tsukasa Ikeura; Mamoru Takenaka; Mitsuharu Fukasawa; Hiroyuki Funayama; Akira Mitoro; Tadayuki Takagi; Masanari Sekine; Kanetoshi Suwa; Junichi Sakagami; Masaharu Ishida; Masayuki Ohtsuka; S. hingo Kagawa; Takashi Muraki; Takayuki Watanabe; Takashi Watanabe; Katsunori Yamamoto; T. omohiro Masaka; Masatsugu Nagahama; Ai Sato; Yukio Aruga; Yousuke Nakai; Eisuke Iwasaki; T. akao Itoi; Yuki Kawaji; Masayuki Kitano; Kazuhiro Mizukami; Susumu Iwasaki; Masashi Mori; Naoya Kaneko; Yuzo Kodama; Hiroko Sato; Naoki Yoshida; Katsuko Hatayama; Takashi Kobayashi; Atsuyuki Hirano; Miyuki Kaino; Toshio Fujisawa; Tomoyuki Ushijima; Mitsuru Chiba; K. yoko Shimizu; Hirotaka Ota; Masao Toki; Takao Nishikawa; Yu Yoshida; Kei Tanaka; Kota Uetsuki; Daisuke Motoya; Shinichiro Muro; Hiroyuki Watanabe; Yoshiki Imamura; Tetsuya Ishizawa; Terumi Kamisawa; M. io Tsuruoka; Kazunao Hayashi; Shuji Terai; K. unio Iwatsuka; Keisuke Iwata; Motoyuki Yoshida; T. omofumi Takagi; Manabu Goto; Noriko Oza; Y. asuhito Takeda; Hideki Hagiwara; Toshihiro Tadano; Toshitaka Sakai; Kimi Sumimoto; Nauro Nishimura; Atsushi Irisawa; Masaki Kuwatani; Nakao Shirahata; Masahiro Satoh
Journal of Gastroenterology, 2020
Scientific journal - Nationwide epidemiological survey of autoimmune pancreatitis in Japan in 2016.
Masamune A; Kikuta K; Hamada S; Tsuji I; Takeyama Y; Shimosegawa T; Okazaki K; Collaborators. Collaborators; Kanno A; Sano T; Uchida K; Ikeura T; Fujimori N; Nakai Y; Kamisawa T; Kubota K; Motoya M; Shimizu K; Ushijima T; Fukasawa M; Naitoh I; Ueno M; Okuwaki K; Uza N; Asada M; Mukai T; Kudo Y; Uetsuki K; Mitoro A; Watanabe H; Terai S; Hayashi K; Imamura Y; Haba S; Hara K; Fujisawa T; Iwasaki E; Okumura F; Kawaji Y; Kitano M; Nishino T; Nagahama M; Hirano A; Aruga Y; Yamamoto S; Inui K; Kubota Y; Takahashi K; Sakagami J; Kobayashi T; Miraki T; Watanabe T; Sato H; Takeda Y; Satoh M; Kobashigawa K; Chiba M; Tamura T; Sawada N; Mizukami K; Sekine M; Unno J; Ishizawa T; Funayama H; Hatayama K; Miyakawa H; Sakai T; Kuwatani M; Toki M, To
Journal of Gastroenterology, 55, 4, 462, 470, Dec. 2019, [Peer-reviewed]
English, Scientific journal - 【肝胆膵の救急疾患とその最新の治療現場】肝胆膵における比較的新しい救急疾患概念 膵仮性嚢胞・WONへのアプローチ
桑谷 将城; 川久保 和道; 加藤 新; 平田 幸司; 平田 甫; 坂本 直哉
肝胆膵, 79, 4, 705, 711, (株)アークメディア, Oct. 2019
Japanese - 悪性肝門部胆管閉塞症例の術前内視鏡的経鼻胆管ドレナージチューブ閉塞の危険因子解析
杉浦 諒; 桑谷 将城; 平田 甫; 中島 正人; 平田 幸司; 加藤 新; 坂本 直哉
胆道, 33, 3, 493, 493, 日本胆道学会, Oct. 2019
Japanese - 膵頭部癌に対する術前内視鏡的胆管ステント留置術の臨床成績
平田 甫; 桑谷 将城; 中島 正人; 平田 幸司; 杉浦 諒; 加藤 新; 坂本 直哉; 浅野 賢道; 平野 聡
胆道, 33, 3, 548, 548, 日本胆道学会, Oct. 2019
Japanese - 遠位良性胆道狭窄に対する経乳頭的金属ステント留置の効果
加藤 新; 桑谷 将城; 平田 甫; 滝新 悠之介; 平田 幸司; 古川 龍太郎; 坂本 直哉
胆道, 33, 3, 603, 603, 日本胆道学会, Oct. 2019
Japanese - さあ、どうする?治療内視鏡におけるトラブルシューティング(胆膵編) 胆管金属ステント留置後reintervention困難例におけるESダイレーターの有用性
加藤 新; 桑谷 将城; 坂本 直哉
Gastroenterological Endoscopy, 61, Suppl.2, 2054, 2054, (一社)日本消化器内視鏡学会, Oct. 2019
Japanese - Correlation between Liver Elasticity by Ultrasound Elastography and Liver Functional Reserve
Ryo Sugiura; Masaki Kuwatani; Mutsumi Nishida; Koji Hirata; Itsuki Sano; Shin Kato; Kazumichi Kawakubo; Masato Nakai; Takuya Sho; Goki Suda; Kenichi Morikawa; Koji Ogawa; Naoya Sakamoto
Ultrasound in Medicine & Biology, Oct. 2019, [Peer-reviewed]
Scientific journal - 膵胆管合流異常症における画像所見の検討
古川 龍太郎; 桑谷 将城; 平田 甫; 滝新 悠之介; 平田 幸司; 加藤 新; 岡村 圭佑; 平野 聡; 坂本 直哉
日本消化器病学会北海道支部例会プログラム・抄録集, 125回, 34, 34, 日本消化器病学会-北海道支部, Sep. 2019
Japanese - 胆管空腸吻合部狭窄に対するバルーン内視鏡治療の臨床成績
平田 甫; 桑谷 将城; 瀧新 悠之介; 古川 龍太郎; 平田 幸司; 加藤 新; 坂本 直哉
日本消化器病学会北海道支部例会プログラム・抄録集, 125回, 35, 35, 日本消化器病学会-北海道支部, Sep. 2019
Japanese - 胆嚢原発神経内分泌腫瘍の4症例
滝新 悠之介; 桑谷 将城; 古川 龍太郎; 平田 甫; 平田 幸司; 加藤 新; 坂本 直哉; 岡村 圭祐; 平野 聡; 三橋 智子
日本消化器病学会北海道支部例会プログラム・抄録集, 125回, 37, 37, 日本消化器病学会-北海道支部, Sep. 2019
Japanese - Clinical usefulness of conversion surgery for unresectable pancreatic cancer diagnosed on multidetector computed tomography imaging: Results from a multicenter observational cohort study by the Hokkaido Pancreatic Cancer Study Group (HOPS UR-01).
Yasutoshi Kimura; Toru Nakamura; Tsuyoshi Hayashi; Masaki Kuwatani; Masayo Motoya; Makoto Yoshida; Masafumi Imamura; Minoru Nagayama; Hiroshi Yamaguchi; Keisuke Yamakita; Takuma Goto; Yusuke Sakuhara; Kuniyuki Takahashi; Hiroyuki Maguchi; Satoshi Hirano; Ichiro Takemasa
Annals of gastroenterological surgery, 3, 5, 523, 533, Sep. 2019, [Domestic magazines]
English, Scientific journal, Background and Aim: Effective multidisciplinary approaches for unresectable pancreatic cancer (UR-PC) that include modern chemotherapeutic regimens and subsequent conversion surgery (CS) are being developed. The aim of this study was to evaluate outcomes of patients clinically diagnosed with UR-PC, focusing on the efficacy of CS. Methods: Patients ineligible for two multicenter phase II studies conducted by the Hokkaido Pancreatic Cancer Study Group (HOPS) were recruited. Sequential treatment regimens, conversion to radical surgery, and overall survival (OS) were analyzed by multidetector computed tomography (MDCT)-based UR factors. Univariate and multivariate analyses were performed to identify predictors of OS. Results: Sixty-six of 247 intended recruits for HOPS studies from October 2013 to April 2016 were included. Unresectability was due to locally advanced (LA) disease and metastasis (M) in 42 and 24 patients, respectively. Induction therapy began with chemotherapy (CT) and chemoradiotherapy (CRT) in 44 and 17 patients, respectively, of whom 23 received modern CT regimens. Radical surgery was completed in 12 (LA, 10; M, two) with a median treatment interval of 10.3 months (range, 2-32). Eleven patients (91.6%) achieved pathological R0 resection. Median OS was significantly longer in patients who underwent CS than those who did not (44.1 vs 14.5 months, P < 0.0001). CS was an independent predictor of OS (hazard ratio, 0.078; 95% confident interval, 0.017-0.348; P = 0.001). Conclusion: Conversion surgery after a favorable response to sequential treatment might prolong survival in patients with UR-PC. Precise diagnosis on MDCT followed by sequential multimodal anticancer treatment is essential. - Effect of Pancreatic Mass Size on Clinical Outcomes of Endoscopic Ultrasound-Guided Fine-Needle Aspiration.
Sugiura R; Kuwatani M; Hirata K; Sano I; Kato S; Kawakubo K; Sakamoto N
Digestive diseases and sciences, 64, 7, 2006, 2013, Jul. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: Endoscopic ultrasonography-guided fine-needle aspiration (EUS-FNA) has high diagnostic accuracy for pancreatic diseases. However, the effect of mass size on diagnostic accuracy has yet to be determined, especially for small pancreatic lesions. We aimed to determine the effect of pancreatic mass size on the diagnostic yield of EUS-FNA. METHODS: We searched the database in Hokkaido University Hospital between May 2008 and December 2016 and identified solid pancreatic lesions examined by EUS-FNA. All lesions were stratified into five groups based on mass sizes: groups A (< 10 mm), B (10-20 mm), C (20-30 mm), D (30-40 mm) and E (≥ 40 mm). The sensitivity, specificity, diagnostic accuracy and adverse event rate were retrospectively evaluated. RESULTS: We analyzed a total of 788 solid pancreatic lesions in 761 patients. The patients included 440 males (57.8%) with a mean age of 65.7 years. The sensitivities in groups A (n = 36), B (n = 223), C (n = 304), D (n = 147) and E (n = 78) were 89.3%, 95.0%, 97.4%, 98.5% and 98.7%, respectively, and they significantly increased as the mass size increased (P < 0.01, chi-squared test for trend). The diagnostic accuracies were 91.7%, 96.4%, 97.7%, 98.6% and 98.7%, respectively, and they also significantly increased as the mass size increased (P = 0.03). Multivariate analysis showed that pancreatic mass size was associated with diagnostic accuracy. The adverse event rates were not significantly different among the five groups. CONCLUSIONS: The sensitivities and diagnostic accuracies of EUS-FNA for solid pancreatic lesions are higher for lesions ≥ 10 mm in size, and they are strongly correlated with mass size. - Short- and long-term outcomes of a novel transpapillary dilation technique using a diathermic dilator for severe benign bile duct stricture.
Kato S; Kuwatani M; Kawakubo K; Sugiura R; Hirata K; Nakajima M; Hirata H; Kawakami H; Sakamoto N
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 31, 4, 448, 452, Jul. 2019, [Peer-reviewed], [International Magazine]
English, Endoscopic dilation for severe benign biliary stricture using mechanical dilation devices is occasionally ineffective. Hence, diathermic dilation has recently been gaining attention as a salvage procedure. We evaluated the short- and long-term outcomes of diathermic dilation for severe benign biliary stricture that could not be dilated using conventional mechanical dilation. Thirteen consecutive cases with severe benign biliary stricture that underwent diathermic dilation using 6-Fr electrocautery dilator were enrolled. Short- and long-term outcomes were analyzed. Diathermic dilation was successful in 13 cases (100%), whereas stent was successfully placed in 12 cases (92.3%). Adverse events occurred in two cases (15.4%): mild hemobilia and cholangitis. Recurrence of bile duct stricture was observed in five out of 12 cases (41. 7%) in the 1115-day median follow-up period. Finally, eight cases achieved stent-free state (61.5%) and have remained stent-free without any episode of cholangitis and abnormal liver function test. Diathermic dilation using 6-Fr electrocautery dilator is a promising salvage procedure for severe benign biliary stricture when the conventional dilation technique has been ineffective. - 血漿遊離核酸を用いた膵腫瘍診断
岡田 哲弘; 水上 裕輔; 河本 徹; 林 明宏; 佐藤 裕基; 河端 秀賢; 後藤 拓磨; 笹島 順平; 小泉 一也; 高橋 邦幸; 岩野 博俊; 浅原 新吾; 桑谷 将城; 唐崎 秀則; 奥村 利勝
膵臓, 34, 3, A106, A107, 日本膵臓学会, Jun. 2019
Japanese - Verification of the effectiveness of fucosylated haptoglobin as a pancreatic cancer marker in clinical diagnosis.
Masaki Kuwatani; Hiroshi Kawakami; Yoshimasa Kubota; Kazumichi Kawakubo; Yoichi M Ito; Shinji Togo; Takaaki Ikeda; Ken Kusama; Yuka Kobayashi; Teizo Murata; Naoya Sakamoto
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 19, 4, 569, 577, Jun. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: Fucosylated haptoglobin detected by Pholiota squarrosa lectin (PhoSL) that had specificity for fucose α1-6 was reported as an effective biomarker for several gastrointestinal diseases. The aim of this study was to verify Fucosylated haptoglobin detected by Pholiota squarrosa lectin (PhoSL-HP) as a pancreatic cancer (PC) marker using a new method of PhoSL-ELISA. METHODS: PhoSL-HP in sera from 98 PC patients and 158 non-PC samples including 32 intraductal papillary mucinous neoplasm (IPMN) patients, 21 chronic pancreatitis (CP) patients and 105 non-pancreatic disease controls (NPDC) were measured. We compared sensitivities, specificities and areas under the curves (AUC) of PhoSL-HP, CA19-9 and CEA as single markers. We also evaluated PhoSL-HP as combination marker by comparing AUC of CA19-9 combined with PhoSL-HP or CEA. RESULTS: The sensitivities of PhoSL-HP, CA19-9 and CEA for PC were 58%, 76% and 42%, respectively. Although the specificity of PhoSL-HP for NPDC was inferior to both of CA19-9 and CEA, that for pancreatic diseases was higher than both of CA19-9 and CEA. Combined CA19-9 with PhoSL-HP, the AUC was significantly higher at 0.880 than single use of CA19-9 at 0.825 in case of distinguishing PC from other pancreatic diseases. In contrast, the AUC of CA19-9 was not elevated significantly when combined with CEA. CONCLUSION: PhoSL-HP would be a useful marker for PC and have sufficient complementarity for CA19-9. - 主膵管閉塞を伴わない悪性胆管狭窄に対する金属ステント留置時の乳頭括約筋切開の必要性 多施設共同傾向スコア解析研究
加藤 新; 桑谷 将城; 江藤 和範; 小野 道洋; 大和 弘明; 江平 宣起; 佐野 逸紀; 庵原 秀之; 久保 公利; 坂本 直哉
Gastroenterological Endoscopy, 61, Suppl.1, 864, 864, (一社)日本消化器内視鏡学会, May 2019
Japanese - 内視鏡的乳頭括約筋切開術による出血に対する治療法
平田 甫; 桑谷 将城; 坂本 直哉; 中島 正人; 平田 幸司; 杉浦 諒; 加藤 新
Gastroenterological Endoscopy, 61, Suppl.1, 922, 922, (一社)日本消化器内視鏡学会, May 2019
Japanese - Synchronous multiple pancreatic cancers developed long after severe postendoscopic retrograde cholangiopancreatography pancreatitis.
Sugiura R; Kuwatani M; Hirata K; Kato S; Kawamoto Y; Kawakubo K; Mitsuhashi T; Asano T; Hirano S; Sakamoto N
Endoscopic ultrasound, 8, 3, 213, 214, May 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal - 胆道腫瘍に対する診療の進歩 超音波内視鏡下穿刺生検検体による胆道癌遺伝子解析
平田 幸司; 桑谷 将城; 坂本 直哉
日本消化器病学会雑誌, 116, 臨増総会, A74, A74, (一財)日本消化器病学会, Mar. 2019
Japanese - 胆道病変に対する超音波内視鏡下穿刺吸引法の臨床成績
平田 甫; 桑谷 将城; 中島 正人; 平田 幸司; 杉浦 諒; 加藤 新; 坂本 直哉
日本消化器病学会北海道支部例会プログラム・抄録集, 124回, 66, 66, 日本消化器病学会-北海道支部, Mar. 2019
Japanese - Unusual reintervention through a fistula for ampullary penetration of a plastic stent in malignant distal biliary obstruction
Ryo Sugiura; Masaki Kuwatani; Naoya Sakamoto
Digestive Endoscopy, 31, 2, e48, e49, Mar. 2019, [Peer-reviewed]
Scientific journal - Long-term outcomes after therapeutic endoscopic retrograde cholangiopancreatography using balloon-assisted enteroscopy for anastomotic stenosis of choledochojejunostomy/pancreaticojejunostomy.
Sano I; Katanuma A; Kuwatani M; Kawakami H; Kato H; Itoi T; Ono M; Irisawa A; Okabe Y; Iwashita T; Yasuda I; Ryozawa S; Kaino S; Sakamoto N
Journal of gastroenterology and hepatology, 34, 3, 612, 619, Mar. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND AND AIM: Data on long-term outcomes after therapeutic endoscopic retrograde cholangiopancreatography (ERCP) using balloon-assisted enteroscopy (BAE) for choledochojejunal anastomotic stenosis (CJS) or pancreaticojejunal anastomotic stenosis (PJS) remain limited. We retrospectively assessed the long-term results of patients who achieved clinical success using BAE for CJS and PJS. METHODS: Patients who achieved technical and clinical success for CJS or PJS by BAE-ERCP and were followed up for more than 6 months after the initial BAE-ERCP therapy were retrospectively identified at 11 Japanese institutions. The primary end-point was CJS or PJS recurrence rates. The secondary end-points were initial therapy details, initial therapy complications, and CJS or PJS recurrence treatment details. We also evaluated restenosis-associated factors. RESULTS: From September 2008 to December 2015, 67 patients (CJS, 61; PJS, six) were included. The overall CJS and PJS recurrence rates were 34.4% and 33.3%, respectively. The 1-year CJS recurrence rate was 18.5% (95% confidence interval, 10.7-31.0). Of all the patients, 88.1% underwent balloon dilation at the anastomotic stenosis site; stent placement was performed in 15 of 67 patients (22.4%). The complication rate was 8.2% in CJS and 0% in PJS. In patients who underwent balloon dilation, "remaining waist" was significantly associated with CJS recurrence after anastomotic balloon dilation (P = 0.001). CONCLUSIONS: The long-term outcomes of BAE-ERCP were comparable with those of percutaneous transhepatic treatment or surgical re-anastomosis. - Better too big than too small?
Kawakubo K; Kuwatani M; Kato S; Sakamoto N
Gastrointestinal endoscopy, 89, 3, 650, 651, Mar. 2019, [Peer-reviewed], [International Magazine]
English - Prospective, multicenter, observational study of tissue acquisition through EUS-guided fine-needle biopsy using a 25G Franseen needle.
Sugiura R; Kuwatani M; Yane K; Taya Y; Ihara H; Onodera M; Eto K; Sano I; Kudo T; Mitsuhashi T; Katanuma A; Sakamoto N; Hokkaido Interventional EUS; ERCP study; HONEST) group
Endoscopic ultrasound, Mar. 2019, [Peer-reviewed] - A Novel Approach for the Genetic Analysis of Biliary Tract Cancer Specimens Obtained Through Endoscopic Ultrasound-Guided Fine Needle Aspiration Using Targeted Amplicon Sequencing.
Hirata K; Kuwatani M; Suda G; Ishikawa M; Sugiura R; Kato S; Kawakubo K; Sakamoto N
Clinical and translational gastroenterology, 10, 3, e00022, Mar. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, OBJECTIVES: Biliary tract cancer (BTC) is an aggressive malignant tumor, and biomarker-based clinical trials for this cancer are currently ongoing. Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is a safe procedure and enables pathological diagnoses; however, it is uncertain whether a tiny tumor sample of BTC obtained through EUS-FNA can be analyzed for diverse genetic alterations in the development and tolerance of BTC. Thus, we aimed to verify the feasibility of genetic analyses with EUS-FNA samples of BTC. METHODS: Targeted amplicon sequencing using a cancer gene panel with 50 genes was performed with tissue samples of 21 BTC patients obtained through EUS-FNA with a novel rapid on-site process compared with paired peripheral blood samples. RESULTS: Pathogenic gene alterations were successfully identified in 20 out of 21 patients (95.2%) with EUS-FNA specimens of BTC, which included 19 adenocarcinomas and 2 adenosquamous carcinomas. Eighty single nucleotide variants and 8 indels in 39 genes were identified in total, and 28 pathogenic alterations in 14 genes were identified (average, 1.4 alterations per patient). The most common alterations were TP53, KRAS, and CDKN2A in gallbladder carcinoma; TP53, KRAS, PIK3CA, and BRAF in intrahepatic cholangiocarcinoma; and TP53 and SMAD4 in extrahepatic cholangiocarcinoma. Actionable gene alterations (BRAF, NRAS, PIK3CA, and IDH1) were identified in 7 out of 21 patients. CONCLUSIONS: A novel approach in genetic analysis using targeted amplicon sequencing with BTC specimens obtained through EUS-FNA was feasible and enabled us to identify genomic alterations. - 超音波内視鏡下穿刺吸引検体により診断可能であった後腹膜胚細胞腫瘍の一例
出口 貴祥; 丸川 活司; 高桑 恵美; 安孫子 光春; 清水 知浩; 恩田 千景; 宮越 里絵; 渡部 涼子; 岡田 宏美; 中 智昭; 加藤 新; 桑谷 将城; 三橋 智子; 松野 吉宏
北海道臨床細胞学会会報, 27, 21, 26, 北海道臨床細胞学会, Nov. 2018
Japanese - EUS versus transpapillary drainage of malignant biliary obstruction: still a long way to go.
Kawakubo K; Kuwatani M; Sakamoto N
Gastrointestinal endoscopy, 88, 5, 884, Nov. 2018, [Peer-reviewed] - Interventional EUSのトラブルシューティング 超音波内視鏡下胆管消化管吻合術における瘻孔拡張の実際とトラブルシューティング
平田 幸司; 桑谷 将城; 坂本 直哉
Gastroenterological Endoscopy, 60, Suppl.2, 2048, 2048, (一社)日本消化器内視鏡学会, Oct. 2018
Japanese - Interventional EUSのトラブルシューティング 超音波内視鏡下胆管消化管吻合術における瘻孔拡張の実際とドラブルシューティング
平田 幸司; 桑谷 将城; 坂本 直哉
日本消化器病学会雑誌, 115, 臨増大会, A680, A680, (一財)日本消化器病学会, Oct. 2018
Japanese - Innovative therapeutic endoscopy良性胆管・膵管狭窄に対する内視鏡治療 良性胆管・膵管狭窄に対する経乳頭的通電拡張術の効果
加藤 新; 桑谷 将城; 坂本 直哉
Gastroenterological Endoscopy, 60, Suppl.2, 2013, 2013, (一社)日本消化器内視鏡学会, Oct. 2018
Japanese - 良性胆管・膵管狭窄に対する内視鏡治療 良性胆管・膵管狭窄に対する経乳頭的通電拡張術の効果
加藤 新; 桑谷 将城; 坂本 直哉
日本消化器病学会雑誌, 115, 臨増大会, A633, A633, (一財)日本消化器病学会, Oct. 2018
Japanese - Direct recanalization of pancreaticogastrostomy obstruction with a forward-viewing echoendoscope.
Kuwatani M; Kato S; Sakamoto N
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 31, 1, e18, e19, Oct. 2018, [Peer-reviewed], [International Magazine]
English, Scientific journal - No difference does not always mean equivalent.
Kawakubo K; Kuwatani M; Sakamoto N
Gastrointestinal endoscopy, 88, 3, 573, Sep. 2018, [Peer-reviewed] - 術後胆汁漏・胆道狭窄に対する治療戦略-内科、外科の立場から- 術後胆汁瘻に対する内視鏡的治療の実際と経皮的治療との比較
平田 幸司; 桑谷 将城; 平田 甫
胆道, 32, 3, 408, 408, (一社)日本胆道学会, Aug. 2018
Japanese - Hepatobiliary and Pancreatic: Pancreatic cancer with elevated serum IgG4 level due to multiple myeloma mimicking localized autoimmune pancreatitis
S. Kato; M. Kuwatani; K. Kawakubo; R. Sugiura; K. Hirata; S. Tanikawa; T. Mitsuhashi; S. Shiratori; N. Sakamoto
Journal of Gastroenterology and Hepatology (Australia), 33, 7, 1310, Blackwell Publishing, 01 Jul. 2018, [Peer-reviewed]
English - Successful endoscopic sphincterotomy for choledocholithiasis in a patient with severe hemophilia A and inhibitors
Ryo Sugiura; Masaki Kuwatani; Kazumichi Kawakubo; Itsuki Sano; Shin Kato; Tomoyuki Endo; Naoya Sakamoto
Clinical Journal of Gastroenterology, 11, 3, 188, 192, Springer Tokyo, 01 Jun. 2018, [Peer-reviewed]
English, Scientific journal - A prospective multicenter study evaluating bleeding risk after endoscopic ultrasound-guided fine needle aspiration in patients prescribed antithrombotic agents
Kazumichi Kawakubo; Kei Yane; Kazunori Eto; Hirotoshi Ishiwatari; Nobuyuki Ehira; Shin Haba; Ryusuke Matsumoto; Keisuke Shinada; Hiroaki Yamato; Taiki Kudo; Manabu Onodera; Toshinori Okuda; Yoko Taya-Abe; Shuhei Kawahata; Kimitoshi Kubo; Yoshimasa Kubota; Masaki Kuwatani; Hiroshi Kawakami; Akio Katanuma; Michihiro Ono; Tsuyoshi Hayashi; Minoru Uebayashi; Naoya Sakamoto
Gut and Liver, 12, 3, 353, 359, Editorial Office of Gut and Liver, 01 May 2018, [Peer-reviewed]
English, Scientific journal - Mixed ductal-neuroendocrine carcinoma with unique intraductal growth in the main pancreatic duct.
Hirata K; Kuwatani M; Mitsuhashi T; Sugiura R; Kato S; Kawakubo K; Yamada T; Asano T; Hirano S; Sakamoto N
Endoscopic ultrasound, 8, 2, 129, 130, May 2018, [Peer-reviewed], [International Magazine]
English, Scientific journal - Combined use of a two-channel endoscope and a flexible tip catheter for difficult biliary cannulation
Masaki Kuwatani; Yoshimasa Kubota; Shuhei Kawahata; Kimitoshi Kubo; Kazumichi Kawakubo; Hiroshi Kawakami; Naoya Sakamoto
International Journal of Gastrointestinal Intervention, 7, 1, 34, 35, Society of Gastrointestinal Intervention, 30 Apr. 2018, [Peer-reviewed]
Scientific journal - 遠位胆管金属ステント閉塞への対処 double stentingとpigtail stentによる工夫
平田 幸司; 桑谷 将城; 杉浦 諒; 加藤 新; 川久保 和道; 坂本 直哉
Gastroenterological Endoscopy, 60, Suppl.1, 742, 742, (一社)日本消化器内視鏡学会, Apr. 2018
Japanese - 胆管ステントの現況と将来 悪性胆道狭窄に対するメタリックステント留置時の乳頭括約筋切開術付加は、ERCP後膵炎の発症を抑制するか
加藤 新; 桑谷 将城; 坂本 直哉
Gastroenterological Endoscopy, 60, Suppl.1, 612, 612, (一社)日本消化器内視鏡学会, Apr. 2018
Japanese - 肝門部領域胆管癌の胆管水平方向進展診断における経乳頭的鉗子生検の診断能
杉浦 諒; 桑谷 将城; 平田 幸司; 加藤 新; 川久保 和道; 坂本 直哉
日本消化器病学会雑誌, 115, 臨増総会, A301, A301, (一財)日本消化器病学会, Mar. 2018
Japanese - International study of endoscopic management of distal malignant biliary obstruction combined with duodenal obstruction
Tsuyoshi Hamada; Yousuke Nakai; James Y. Lau; Jong Ho Moon; Tsuyoshi Hayashi; Ichiro Yasuda; Bing Hu; Dong-Wan Seo; Hiroshi Kawakami; Masaki Kuwatani; Akio Katanuma; Masayuki Kitano; Shomei Ryozawa; Keiji Hanada; Takuji Iwashita; Yukiko Ito; Hiroshi Yagioka; Osamu Togawa; Iruru Maetani; Hiroyuki Isayama
Scandinavian Journal of Gastroenterology, 53, 1, 46, 55, Taylor and Francis Ltd, 02 Jan. 2018, [Peer-reviewed]
English, Scientific journal - Effects of human amnion-derived mesenchymal stem cells and conditioned medium in rats with sclerosing cholangitis.
Sugiura R; Ohnishi S; Ohara M; Ishikawa M; Miyamoto S; Onishi R; Yamamoto K; Kawakubo K; Kuwatani M; Sakamoto N
American journal of translational research, 10, 7, 2102, 2114, 2018, [Peer-reviewed]
English, Scientific journal - Identification of novel serum autoantibodies against EID3 in non-functional pancreatic neuroendocrine tumors.
Hontani K; Tsuchikawa T; Hiwasa T; Nakamura T; Ueno T; Kushibiki T; Takahashi M; Inoko K; Takano H; Takeuchi S; Dosaka-Akita H; Kuwatani M; Sakamoto N; Hatanaka Y; Mitsuhashi T; Shimada H; Shichinohe T; Hirano S
Oncotarget, 8, 63, 106206, 106221, Dec. 2017, [Peer-reviewed], [International Magazine]
English, Scientific journal, Pancreatic neuroendocrine tumors (pNETs) are relatively rare heterogenous tumors, comprising only 1-2% of all pancreatic neoplasms. The majority of pNETs are non-functional tumors (NF-pNETs) that do not produce hormones, and as such, do not cause any hormone-related symptoms. As a result, these tumors are often diagnosed at an advanced stage because patients do not present with specific symptoms. Although tumor markers are used to help diagnosis and predict some types of cancers, chromogranin A, a widely used tumor marker of pNETs, has significant limitations. To identify novel NF-pNET-associated antigens, we performed serological identification of antigens by recombinant cDNA expression cloning (SEREX) and identified five tumor antigens (phosphatase and tensin homolog, EP300-interacting inhibitor of differentiation 3 [EID3], EH domain-containing protein 1, galactoside-binding soluble 9, and BRCA1-associated protein). Further analysis using the AlphaLISA® immunoassay to compare serum antibody levels revealed that antibody levels against the EID3 antigen was significantly higher in the patient group than in the healthy donor group (n = 25, both groups). In addition, higher serum anti-EID3 antibody levels in NF-pNET patients correlated with shorter disease-free survival. The AUC calculated by ROC analysis was 0.784 with moderate diagnostic accuracy. In conclusion, serum anti-EID3 antibody levels may be useful as a tumor marker for prediction of tumor recurrence in NF-pNETs. - 先天性胆道拡張症に発生した多発胆道癌に対し、生体肝移植と膵頭十二指腸切除を同時に実施した1例
腰塚 靖之; 川村 典生; 渡辺 正明; 後藤 了一; 太田 稔; 川久保 和道; 桑谷 将城; 山下 健一郎; 武冨 紹信; 蒲池 浩文; 神山 俊哉; 嶋村 剛
移植, 52, 4-5, 454, 455, (一社)日本移植学会, Nov. 2017
Japanese - 転移性および原発性病変による肝門部悪性胆管狭窄に対する内視鏡的胆管ドレナージ術の臨床成績
杉浦 諒; 桑谷 将城; 佐野 逸紀; 加藤 新; 川久保 和道; 坂本 直哉
胆道, 31, 3, 566, 566, (一社)日本胆道学会, Aug. 2017
Japanese - Brain micro-inflammation at specific vessels dysregulates organ-homeostasis via the activation of a new neural circuit
Yasunobu Arima; Takuto Ohki; Naoki Nishikawa; Kotaro Higuchi; Mitsutoshi Ota; Yuki Tanaka; Junko Nio-Kobayashi; Mohamed Elfeky; Ryota Sakai; Yuki Mori; Tadafumi Kawamoto; Andrea Stofkova; Yukihiro Sakashita; Yuji Morimoto; Masaki Kuwatani; Toshihihiko Iwanaga; Yoshichika Yoshioka; Naoya Sakamoto; Akihiko Yoshimura; Mitsuyoshi Takiguchi; Saburo Sakoda; Marco Prinz; Daisuke Kamimura; Masaaki Murakami
ELIFE, 6, Aug. 2017, [Peer-reviewed]
English, Scientific journal - Direct puncture of the ampulla as a modified Endoscopic ultrasound-guided rendezvous technique.
Kawakubo K; Kuwatani M; Kato S; Sugiura R; Sano I; Sakamoto N
Endoscopic ultrasound, Aug. 2017, [Peer-reviewed] - Effect of endoscopic transpapillary biliary drainage with/without endoscopic sphincterotomy on postendoscopic retrograde cholangiopancreatography pancreatitis in patients with biliary stricture (E-BEST): a protocol for a multicentre randomised controlled trial
Shin Kato; Masaki Kuwatani; Ryo Sugiura; Itsuki Sano; Kazumichi Kawakubo; Kota Ono; Naoya Sakamotol
BMJ OPEN, 7, 8, e017160, Aug. 2017, [Peer-reviewed]
English, Scientific journal - Mesenchymal stem cell therapy for acute and chronic pancreatitis.
Kawakubo K; Ohnishi S; Kuwatani M; Sakamoto N
Journal of gastroenterology, 53, 1, 1, 5, Jun. 2017, [Peer-reviewed] - Comparison of efficacy and toxicity of FOLFIRINOX and gemcitabine with nab-paclitaxel in unresectable pancreatic cancer.
Muranaka T; Kuwatani M; Komatsu Y; Sawada K; Nakatsumi H; Kawamoto Y; Yuki S; Kubota Y; Kubo K; Kawahata S; Kawakubo K; Kawakami H; Sakamoto N
Journal of gastrointestinal oncology, 8, 3, 566, 571, Jun. 2017, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: Irinotecan, oxaliplatin and leucovorin-modulated fluorouracil (FOLFIRINOX) and the combination regimen of gemcitabine and nanoparticle albumin-bound paclitaxel (GnP) (nab-PTX) improve the prognosis of patients with metastatic pancreatic cancer. However, no study has compared the efficacy of the two regimens. We compared retrospectively the efficacy and safety of the two regimens in patients with unresectable pancreatic cancer. METHODS: Thirty-eight patients with unresectable locally advanced or metastatic pancreatic cancer received FOLFIRINOX or GnP as first-line chemotherapy between December 2013 and September 2015. In the FOLFIRINOX group, patients received 85 mg/m2 oxaliplatin followed by 180 mg/m2 irinotecan and 200 mg/m2 L-leucovorin, and by 400 mg/m2 fluorouracil as a bolus and 2,400 mg/m2 fluorouracil as a 46-h continuous infusion every 14 days. In the GnP group, patients received 125 mg/m2 nab-PTX followed by 1 g/m2, and gemcitabine on days 1, 8 and 15, repeated every 28 days. RESULTS: Response rate was 6.3% in the FOLFIRINOX group and 40.9% in the GnP group (P=0.025). Median progression-free survival (PFS) was 3.7 months [95% confidence interval (CI), 3.0-4.5] in the FOLFIRINOX group and 6.5 months (95% CI, 6.2-6.9 months) in the GnP group (P=0.031). Drug toxicity in the GnP group was less than in the FOLFIRINOX group. CONCLUSIONS: Efficacy and safety of GnP compare favorably to those of FOLFIRINOX in patients with pancreatic cancer. Additional prospective trials are warranted. - International Study of Endoscopic Management of Distal Malignant Biliary Obstruction Combined With Duodenal Obstruction
Tsuyoshi Hamada; Yousuke Nakai; James Y. Lau; Jong Ho Moon; Bing Hu; Dong Wan Seo; Rungsun Rerknimitr; Christopher Khor; Hsiu-Po Wang; Thawee Ratanachu-ek; Sundeep Lakhtakia; Tiing Leong Ang; Ryan Ponnudurai; Iruru Maetani; Tsuyoshi Hayashi; Ichiro Yasuda; Takuji Iwashita; Hiroshi Kawakami; Masaki Kuwatani; Akio Katanuma; Masayuki Kitano; Shomei Ryozawa; Keiji Hanada; Yukiko Ito; Hiroshi Yagioka; Osamu Togawa; Atsushi Irisawa; Takao Itoi; Hiroyuki Isayama; Kazuhiko Koike
GASTROINTESTINAL ENDOSCOPY, 85, 5, AB621, AB621, May 2017, [Peer-reviewed]
English - 高度悪性胆道狭窄に対する経乳頭的通電拡張術の有効性と諸問題
加藤 新; 桑谷 将城; 杉浦 諒; 佐野 逸紀; 川久保 和道; 坂本 直哉
Gastroenterological Endoscopy, 59, Suppl.1, 993, 993, (一社)日本消化器内視鏡学会, Apr. 2017
Japanese - Too short to choose biliary drainage?
Kazumichi Kawakubo; Masaki Kuwatani; Naoya Sakamoto
GASTROINTESTINAL ENDOSCOPY, 85, 3, 690, 690, Mar. 2017, [Peer-reviewed]
English - Rescue technique using a diathermic dilator for an unremovable stent in malignant perihilar biliary obstruction
Ryo Sugiura; Hiroshi Kawakami; Nobuyuki Ehira; Ichiro Iwanaga; Minoru Uebayashi; Masaki Kuwatani; Naoya Sakamoto
ENDOSCOPY, 49, S 01, E42, E45, Feb. 2017, [Peer-reviewed]
English - Reply to Rimbaș et al.
Kawakami H; Kawakubo K; Kubota Y; Kuwatani M; Sakamoto N
Endoscopy, 48, 7, 687, Jul. 2016, [Peer-reviewed] - Reply to Saritas and Ustundag.
Kawakami H; Kawakubo K; Kubota Y; Kuwatani M; Sakamoto N
Endoscopy, 48, 7, 689, Jul. 2016, [Peer-reviewed] - Feasibility of Using an Enzymatically Activatable Fluorescence Probe for the Rapid Evaluation of Pancreatic Tissue Obtained Using Endoscopic Ultrasound-Guided Fine Needle Aspiration: a Pilot Study.
Kawakubo K; Ohnishi S; Hatanaka Y; Hatanaka KC; Hosono H; Kubota Y; Kamiya M; Kuwatani M; Kawakami H; Urano Y; Sakamoto N
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, 18, 3, 463, 471, Springer, Jun. 2016, [Peer-reviewed]
English, Purpose: Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is the most reliable method for the histological diagnosis of pancreatic tumors. Rapid on-site fluorescence-guided histological diagnosis was evaluated by topically applying an enzymatically activatable probe onto the EUS-FNA samples; the probe fluoresces in the presence of γ-glutamyltranspeptidase (GGT). Procedures: We evaluated GGT expression in pancreatic cancer cell lines in vitro. EUS-FNA was performed in 10 pancreatic tumors. After topical application of the probe, signal intensity was measured using a fluorescence imaging system for 13 min. Results: GGT was expressed in Panc-1, AsPC-1, and AR42J, but not in KP4 cells. In samples from six cases, several regions of the specimens fluoresced and contained adequate tissue for pathological diagnosis. The remaining four non-fluorescent samples contained very small amounts of carcinoma, normal epithelial cells, or no epithelial cells. The signal intensity at 5 min was 25.5 ± 7.7 and 7.7 ± 0.5 in fluorescent and non-fluorescent regions, respectively (p < 0.05). Conclusions: Application of enzymatically activatable probe onto EUS-FNA samples would be feasible for the rapid evaluation of tissues suitable for histological diagnosis. - Effect of Fetal Membrane-Derived Mesenchymal Stem Cell Transplantation in Rats With Acute and Chronic Pancreatitis.
Kawakubo K; Ohnishi S; Fujita H; Kuwatani M; Onishi R; Masamune A; Takeda H; Sakamoto N
Pancreas, 45, 5, 707, 713, May 2016, [Peer-reviewed]
English, Scientific journal - Lower incidence of complications in endoscopic nasobiliary drainage for hilar cholangiocarcinoma.
Kawakubo K; Kawakami H; Kuwatani M; Haba S; Kudo T; Taya YA; Kawahata S; Kubota Y; Kubo K; Eto K; Ehira N; Yamato H; Onodera M; Sakamoto N
World journal of gastrointestinal endoscopy, 8, 9, 385, 390, May 2016, [Peer-reviewed] - Eccentric Abscess Due to Bile Duct Microperforation Caused by Self-expandable Metal Stent and Neoadjuvant Chemoradiation
Masaki Kuwatani; Yasuyuki Kawamoto; Toru Nakamura
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 14, 5, XXIX, XXX, May 2016, [Peer-reviewed]
English, Scientific journal - Transpapillary selective bile duct cannulation technique: Review of Japanese randomized controlled trials since 2010 and an overview of clinical results in precut sphincterotomy since 2004.
Kawakami H; Kubota Y; Kawahata S; Kubo K; Kawakubo K; Kuwatani M; Sakamoto N
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 28 Suppl 1, 77, 95, Apr. 2016, [Peer-reviewed] - Double Penetrated Duodenal Wall during Endoscopic Ultrasound-Guided Choledochoduodenostomy.
Kawakami H; Kuwatani M; Sakamoto N
Gut and liver, 10, 2, 318, 319, Mar. 2016, [Peer-reviewed] - Endoscopic ultrasound-guided choledochoduodenostomy vs. transpapillary stenting for distal biliary obstruction.
Kawakubo K; Kawakami H; Kuwatani M; Kubota Y; Kawahata S; Kubo K; Sakamoto N
Endoscopy, 48, 2, 164, 169, Feb. 2016, [Peer-reviewed] - Effect of a stylet on a histological specimen in EUS-guided fine-needle tissue acquisition by using 22-gauge needles: a multicenter, prospective, randomized, controlled trial.
Yoko Abe; Hiroshi Kawakami; Koji Oba; Tsuyoshi Hayashi; Ichiro Yasuda; Tsuyoshi Mukai; Hiroyuki Isayama; Hirotoshi Ishiwatari; Shinpei Doi; Masanori Nakashima; Natsuyo Yamamoto; Masaki Kuwatani; Tomoko Mitsuhashi; Tadashi Hasegawa; Yoshinobu Hirose; Tetsuya Yamada; Mariko Tanaka; Naoya Sakamoto
Gastrointestinal endoscopy, 82, 5, 837, 844, Nov. 2015, [Peer-reviewed], [International Magazine]
English, Scientific journal - 閉塞性黄疸患者における胆道ドレナージ術前後の肝硬度の変化
久保 公利; 河上 洋; 桑谷 将城; 川久保 和道; 阿部 容子; 川畑 修平; 坂本 直哉; 作原 佑介; 白土 博樹; 工藤 悠輔; 西田 睦
日本消化器病学会雑誌, 112, 臨増大会, A855, A855, (一財)日本消化器病学会, Sep. 2015
Japanese - Recent advances in endoscopic ultrasonography-guided biliary interventions
Kawakubo Kazumichi; Kawakami Hiroshi; Kuwatani Masaki; Haba Shin; Kawahata Shuhei; Abe Yoko; Kubota Yoshimasa; Kubo Kimitoshi; Isayama Hiroyuki; Sakamoto Naoya
WORLD JOURNAL OF GASTROENTEROLOGY, 21, 32, 9494, 9502, 28 Aug. 2015, [Peer-reviewed], [International Magazine]
English, Scientific journal - Peroral ultra-slim endoscopy-guided biliary drainage and stone extraction for postoperative upper gastrointestinal stenosis with a naive papilla (with videos)
Hiroshi Kawakami; Masaki Kuwatani; Shuhei Kawahata
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES, 22, 7, 571, 572, Jul. 2015, [Peer-reviewed]
English, Scientific journal - A Novel Technique for the Detection of Endoscopic Ultrasound-Guided Fine Needle Pancreatic Tissue Acquisition by an Enzymatically Rapid-Activatable Fluorescent Probe
Kawakubo Kazumichi; Ohnishi Shunsuke; Urano Yasuteru; Hatanaka Yutaka; Hatanaka Kanako C; Kawakami Hiroshi; Kuwatani Masaki; Kawahata Shuhei; Abe Yoko; Kubota Yoshimasa; Kubo Kimitoshi; Sakamoto Naoya
GASTROINTESTINAL ENDOSCOPY, 81, 5, AB536, AB537, May 2015, [Peer-reviewed] - Pazopanib-Induced Severe Acute Pancreatitis.
Kawakubo K; Hata H; Kawakami H; Kuwatani M; Kawahata S; Kubo K; Imafuku K; Kitamura S; Sakamoto N
Case reports in oncology, 8, 2, 356, 358, Karger, May 2015, [Peer-reviewed]
English, Pazopanib is an oral angiogenesis inhibitor targeting vascular endothelial growth factor receptors, platelet-derived growth factor receptors, and c-Kit approved for the treatment of renal cell carcinoma and soft tissue sarcoma. Nonselective kinase inhibitors, such as sunitinib and sorafenib, are known to be associated with acute pancreatitis. There are few case reports of severe acute pancreatitis induced by pazopanib treatment. We present a case of severe acute pancreatitis caused by pazopanib treatment for cutaneous angiosarcoma. The patient was an 82-year-old female diagnosed with cutaneous angiosarcoma. She had been refractory to docetaxel treatment and began pazopanib therapy. Three months after pazopanib treatment, CT imaging of the abdomen showed the swelling of the pancreas and surrounding soft tissue inflammation without abdominal pain. After she continued pazopanib treatment for 2 months, she presented with nausea and appetite loss. Abdominal CT showed the worsening of the surrounding soft tissue inflammation of the pancreas. Serum amylase and lipase levels were 296 and 177 IU/l, respectively. She was diagnosed with acute pancreatitis induced by pazopanib treatment and was managed conservatively with discontinuation of pazopanib, but the symptoms did not improve. Subsequently, an abdominal CT scan demonstrated the appearance of a pancreatic pseudocyst. She underwent endoscopic ultrasound-guided pseudocyst drainage using a flared-end fully covered self-expandable metallic stent. Then, the symptoms resolved without recurrence. Due to the remarkable progress of molecular targeted therapy, the oncologist should know that acute pancreatitis was recognized as a potential adverse event of pazopanib treatment and could proceed to severe acute pancreatitis. - Technical tips and troubleshooting of endoscopic biliary drainage for unresectable malignant hilar biliary obstruction.
Kawakami H; Itoi T; Kuwatani M; Kawakubo K; Kubota Y; Sakamoto N
Journal of hepato-biliary-pancreatic sciences, 22, 4, E12, 21, Apr. 2015, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, Unresectable malignant hilar biliary obstruction (MHBO) occurs in various diseases, such as cholangiocarcinoma, gallbladder carcinoma, hepatocellular carcinoma, pancreatic cancer, and lymph node metastasis of the hilum of the liver. The majority of patients with advanced MHBO are not candidates for surgical resection because of the tumor location in the hepatic hilum and adjacent areas, advanced tumor stage, or comorbidities. Therefore, these patients often have a poor prognosis in terms of survival and quality of life. Most of these patients will require non-surgical, palliative biliary drainage. To date, various biliary drainage techniques for unresectable MHBO (UMHBO) have been reported. Of these techniques, endoscopic biliary drainage is currently considered to be the most safe and minimally invasive procedure. However, endoscopic biliary drainage for UMHBO is still not standardized regarding the optimal stent, drainage area, stenting method, and reintervention technique. Recently, towards standardization of this technique for UMHBO, clinical research and trials including randomized controlled trials have been performed. In this article, we reviewed the most important issues regarding endoscopic biliary drainage for UMHBO, focusing on prospective studies. We also described in detail the techniques and future perspectives of endoscopic biliary drainage in patients with UMHBO. - Incidental pancreatic cyst is a significant predictor of mortality? What determines life expectancy?
Kawakubo K; Kawakami H; Kuwatani M; Sakamoto N
Radiology, 274, 3, 939, Mar. 2015, [Peer-reviewed] - [Multidisciplinary treatment of gallbladder cancer--biliary and duodenal stenting].
Kawakami H; Kuwatani M; Sakamoto N
Nihon rinsho. Japanese journal of clinical medicine, 73 Suppl 3, 595, 600, Mar. 2015, [Peer-reviewed] - A Unique Use of a Double-Pigtail Plastic Stent: Correction of Kinking of the Common Bile Duct Due to a Metal Stent
Masaki Kuwatani; Hiroshi Kawakami; Yoka Abe; Shuhei Kawahata; Kazumichi Kawakubo; Kimitoshi Kubo; Naoya Sakamoto
GUT AND LIVER, 9, 2, 251, 252, Mar. 2015, [Peer-reviewed]
English, Scientific journal - Single-step simultaneous side-by-side placement of a self-expandable metallic stent with a 6-Fr delivery system for unresectable malignant hilar biliary obstruction: a feasibility study.
Kawakubo K; Kawakami H; Kuwatani M; Kudo T; Abe Y; Kawahata S; Kubo K; Kubota Y; Sakamoto N
Journal of hepato-biliary-pancreatic sciences, 22, 2, 151, 155, Springer Japan, Feb. 2015, [Peer-reviewed]
English - CTNNB1 mutational analysis of solid-pseudopapillary neoplasms of the pancreas using endoscopic ultrasound-guided fine-needle aspiration and next-generation deep sequencing.
Kubota Y; Kawakami H; Natsuizaka M; Kawakubo K; Marukawa K; Kudo T; Abe Y; Kubo K; Kuwatani M; Hatanaka Y; Mitsuhashi T; Matsuno Y; Sakamoto N
Journal of gastroenterology, 50, 2, 203, 210, Springer, Feb. 2015, [Peer-reviewed]
English, Solid-pseudopapillary neoplasm (SPN), a rare neoplasm of the pancreas, frequently harbors mutations in exon 3 of the cadherin-associated protein beta 1 (CTNNB1) gene. Here, we analyzed SPN tissue for CTNNB1 mutations by deep sequencing using next-generation sequencing (NGS). Tissue samples from 7 SPNs and 31 other pancreatic lesions (16 pancreatic ductal adenocarcinomas (PDAC), 11 pancreatic neuroendocrine tumors (PNET), 1 acinar cell carcinoma, 1 autoimmune pancreatitis lesion, and 2 focal pancreatitis lesions) were analyzed by NGS for mutations in exon 3 of CTNNB1. A single-base-pair missense mutations in exon 3 of CTNNB1 was observed in all 7 SPNs and in 1 of 11 PNET samples. However, mutations were not observed in the tissue samples of any of the 16 PDAC or other four pancreatic disease cases. The variant frequency of CTNNB1 ranged from 5.4 to 48.8 %. Mutational analysis of CTNNB1 by NGS is feasible and was achieved using SPN samples obtained by endoscopic ultrasound-guided fine needle aspiration. - 閉塞性黄疸患者における胆道ドレナージ後の肝硬度の変化
久保 公利; 河上 洋; 桑谷 将城; 川久保 和道; 阿部 容子; 川畑 修平; 坂本 直哉; 作原 佑介; 白土 博樹; 西田 睦
超音波医学, 42, 1, 89, 89, (公社)日本超音波医学会, Jan. 2015
Japanese - Pancreatic cancer with infectious pancreatic pseudocyst communicating to the portal vein
KUBO Kimitoshi; KAWAKAMI Hiroshi; KUWATANI Masaki; MITSUHASHI Tomoko; KAWAKUBO Kazumichi; KAWAHATA Shuhei; KUBOTA Yoshimasa; SAKAMOTO Naoya
Suizo, 30, 5, 679, 688, Japan Pancreas Society, 2015
Japanese, A 69-year-old female with fever, a pancreatic mass and portal vein thrombosis was referred to our hospital. Blood culture test was positive for Escherichia coli. Abdominal contrast-enhanced CT revealed a heterogeneously enhanced oval mass in the head of the pancreas with a size of 16×14mm, and a non-enhanced nodule in the portal vein, which was adjacent to a cystic lesion in the body of the pancreas. Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) of the mass in the head of the pancreas indicated adenocarcinoma. On the diagnosis of pancreatic cancer with infectious pseudocyst and portal vein thrombosis, she underwent subtotal stomach-preserving pancreaticoduodenectomy and partial round resection of the portal vein. Histopathological findings of the resected specimen revealed pancreatic head cancer followed by pancreatitis which caused the pancreatic pseudocyst. Infection of the pancreatic pseudocyst would lead to the communication between the cyst and the portal vein. This is the first case with pancreatic cancer with infectious pancreatic pseudocyst communicating to the portal vein. - Development of selective bile duct cannulation
Kawakami Hiroshi; Kuwatani Masaki; Kawakubo Kazumichi; Kawahata Shuhei; Kubota Yoshimasa; Sakamoto Naoya
J.J.B.A, 29, 4, 752, 761, Japan Biliary Association, 2015
Japanese, Nearly 50 years have passed since the first report of endoscopic retrograde cholangiography. Ever since, endoscopic retrograde cholangiopancreatography (ERCP) have been a basic procedure for practice in pancreatico-biliary diseases. Of the various procedures of ERCP, selective biliary cannulation is the most basic and important technique. Various cannulation techniques have been reported with the development of endoscopes and devices. However, there still does not exist the perfect technique that enables selective biliary cannulation for whichever cases. Although contrast medium injection cannulation technique is important, wire-guided cannulation technique has been extended and is now widely performed since early 2000s in the US and Europe. We should use various techniques to achieve safe, accurate and effective bile duct cannulation with a shorter procedure time and reduced complications. Nowadays, recent development of bile duct cannulation, especially transpapillary approach, is discussed in this report. - Direct peroral ultraslim endoscopy-guided biliary drainage in a patient with cystic duct carcinoma and an occluded self-expandable metallic stent.
Kawakami H; Kuwatani M; Abe Y; Kubota Y; Kawakubo K; Kubo K; Kawahata S; Sakamoto N
Endoscopy, 47 Suppl 1, E43, 4, 2015, [Peer-reviewed] - Risk factors for technical failure of endoscopic double self-expandable metallic stent placement by partial stent-in-stent method.
Kawakubo K; Kawakami H; Toyokawa Y; Otani K; Kuwatani M; Abe Y; Kawahata S; Kubo K; Kubota Y; Sakamoto N
Journal of hepato-biliary-pancreatic sciences, 22, 1, 79, 85, Jan. 2015, [Peer-reviewed] - Direct peroral ultraslim endoscopy-guided biliary drainage in a patient with cystic duct carcinoma and an occluded self-expandable metallic stent.
Kawakami H; Kuwatani M; Abe Y; Kubota Y; Kawakubo K; Kubo K; Kawahata S; Sakamoto N
Endoscopy, 47 Suppl 1 UCTN, E43, 4, 2015, [Peer-reviewed] - Huge hemothorax caused by endoscopic ultrasound-guided fine-needle aspiration of a submucosal tumor of the gastric fornix.
Kawakami H; Kuwatani M; Kubo K; Kubota Y; Kawakubo K; Abe Y; Kawahata S; Homma N; Hida Y; Sakamoto N
Endoscopy, 47 Suppl 1 UCTN, E69, 70, 2015, [Peer-reviewed] - A guidewire-assisted biopsy technique to assist advancement through a biliary stricture to perform selective mapping biopsy.
Kawakami H; Kuwatani M; Abe Y; Kawahata S; Kawakubo K; Kubo K; Sakamoto N
Endoscopy, 47 Suppl 1 UCTN, E217, 8, 2015, [Peer-reviewed] - Endoscopic ultrasound-guided pelvic abscess drainage using a dedicated, wide, flared-end, fully covered self-expandable metal stent.
Kawakami H; Kuwatani M; Kawahata S; Kubota Y; Kubo K; Kawakubo K; Sakamoto N
Endoscopy, 47 Suppl 1 UCTN, E265, 6, 2015, [Peer-reviewed] - Endoscopic ultrasound-guided antegrade bile duct stone treatment followed by direct peroral transhepatic cholangioscopy in a patient with Roux-en-Y reconstruction.
Kawakami H; Kuwatani M; Kubota Y; Kawahata S; Kubo K; Kawakubo K; Sakamoto N
Endoscopy, 47 Suppl 1 UCTN, E340, 1, 2015, [Peer-reviewed] - Acute pancreatitis-like bile leakage around the portal vein system after endoscopic ultrasound-guided choledochoduodenostomy.
Kawakami H; Kuwatani M; Kawakubo K; Kubota Y; Kawahata S; Kubo K; Sakamoto N
Endoscopy, 47 Suppl 1 UCTN, E346, 7, 2015, [Peer-reviewed] - Difference from Bile Duct Cancer and Relationship between Bile Duct Wall Thickness And Serum IgG/IgG4 Levels in IgG4-Related Sclerosing Cholangitis
Masaki Kuwatani; Hiroshi Kawakami; Yoh Zen; Kazumichi Kawakubo; Taiki Kudo; Yoko Abe; Kimitoshi Kubo; Naoya Sakamoto
HEPATO-GASTROENTEROLOGY, 61, 135, 1852, 1856, Oct. 2014, [Peer-reviewed]
English, Scientific journal - Effect of antispasmodic drugs on endoscopic ultrasound/endoscopic ultrasound-guided fine-needle aspiration: A multicenter randomized controlled trial.
Masaki Kuwatani; Hiroshi Kawakami; Tsuyoshi Hayashi; Kazunori Eto; Hiroaki Yamato; Manabu Onodera; Hirohito Naruse; Koji Oba
Endoscopic ultrasound, 3, 3, 167, 73, Jul. 2014, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND AND OBJECTIVE: Antispasmodic drugs (ADs) have been used to reduce examination time or improve the quality of gastrointestinal endoscopy, although the practice is controversial. No evidence about the efficacy of AD for endoscopic ultrasonography/EUS-guided fine-needle aspiration (EUS/EUS-FNA) is available. This study was aimed to evaluate the efficacy of AD in EUS/EUS-FNA. PATIENTS AND METHODS: A total of 400 patients with pancreaticobiliary, peripancreatic, or peribiliary disease or disorder undergoing EUS/EUS-FNA were prospectively and evenly randomized to undergo EUS/EUS-FNA with AD (w-AD) or without AD (w/o-AD). The primary endpoint was total EUS/EUS-FNA examination time. The secondary endpoints were visual analogue scale (VAS) scores of endoscopists (patient body motion, gastrointestinal peristalsis, and accomplishment of the purpose) and patients (pain, discomfort, and willingness to undergo re-examination), vital sign changes, adverse events, and sedative dose. RESULTS: Two hundred patients in the w-AD group and 197 patients in the w/o-AD group were ultimately analyzed. The total examination time was similar between the groups (2299 ± 937 vs. 2259 ± 1019 s). The difference in total examination time from w/o-AD group to w-AD group was -40 s (95% confidence interval, -234-153 s), which was within the noninferiority margin. No statistical differences were observed in endoscopist and patient VAS scores, changes in vital signs, adverse events, or total sedative dose other than fentanyl between the groups. CONCLUSION: EUS/EUS-FNA can be effectively and safely performed w/o-AD. Further, randomized controlled trials on EUS/EUS-FNA in various disease entities may be required to confirm the results of this study (UMIN000008047). - Safety and Utility of Single-Session Endoscopic Ultrasonography and Endoscopic Retrograde Cholangiopancreatography for the Evaluation of Pancreatobiliary Diseases
Kazumichi Kawakubo; Hiroshi Kawakami; Masaki Kuwatani; Shin Haba; Taiki Kudo; Yoko Abe; Shuhei Kawahata; Manabu Onodera; Nobuyuki Ehira; Hiroaki Yamato; Kazunori Eto; Naoya Sakamoto
GUT AND LIVER, 8, 3, 329, 332, May 2014, [Peer-reviewed]
English, Scientific journal - Multicenter retrospective study of endoscopic ultrasound-guided biliary drainage for malignant biliary obstruction in Japan.
Kawakubo K; Isayama H; Kato H; Itoi T; Kawakami H; Hanada K; Ishiwatari H; Yasuda I; Kawamoto H; Itokawa F; Kuwatani M; Iiboshi T; Hayashi T; Doi S; Nakai Y
Journal of hepato-biliary-pancreatic sciences, 21, 5, 328, 334, May 2014, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, BACKGROUND: Endoscopic ultrasound-guided biliary drainage (EUS-BD) is considered to be an effective salvage procedure for failed endoscopic retrograde cholangiopancreatography in patients with unresectable malignant biliary obstruction. The aim of this retrospective study was to evaluate the efficacy and feasibility of EUS-BD. METHODS: From November 2006 to May 2012, a total of 64 patients who underwent EUS-BD (44 EUS-guided choledochoduodenostomy [EUS-CDS] and 20 EUS-guided hepaticogastrostomy [EUS-HGS]) at seven tertiary-care referral centers in Japan were included. The primary outcome was the technical success rate, and the secondary outcomes were the incidence of complications, stent dysfunction rate, time to stent dysfunction, and overall survival. RESULTS: The technical success rate for both EUS-CDS and EUS-HGS was 95%. The reasons for technical failure were two failed dilations of the anastomosis in EUS-CDS and one puncture failure in EUS-HGS. The stent dysfunction rate and 3-month dysfunction-free patency rate were 21% and 80% for EUS-CDS and 32% and 51% for EUS-HGS. There were 12 (six in EUS-CDS and six in EUS-HGS) procedure-related complications (19%): five cases of bile leakage (3/2), three stent misplacements (1/2), one pneumoperitoneum (1/0), two cases of bleeding (1/1), one perforation (1/0), and one biloma (0/1). Bile leakage was more frequently observed in patients who underwent plastic stent placement (11%) than in those with covered metal stents (4%). CONCLUSIONS: This Japanese multicenter study revealed a high success rate in EUS-BD. However, the complication rate was as high as that in previous series. Covered metal stents may be useful to reduce bile leakage in EUS-BD. - Influence of the safety and diagnostic accuracy of preoperative endoscopic ultrasound-guided fine-needle aspiration for resectable pancreatic cancer on clinical performance.
Kudo T; Kawakami H; Kuwatani M; Eto K; Kawahata S; Abe Y; Onodera M; Ehira N; Yamato H; Haba S; Kawakubo K; Sakamoto N
World journal of gastroenterology, 20, 13, 3620, 3627, Apr. 2014, [Peer-reviewed] - Is intraductal papillary mucinous neoplasm of the pancreas just a precursor or identical with pancreatic ductal adenocarcinoma?
Kawakubo K; Kawakami H; Kuwatani M; Sakamoto N
The American journal of gastroenterology, 109, 3, 446, 447, Mar. 2014, [Peer-reviewed] - 脂肪組織と石灰化成分を内部に含有した胆嚢癌の1例
桑谷 将城; 河上 洋; 川久保 和道; 工藤 大樹; 阿部 容子; 羽場 真; 田中 栄一; 平野 聡; 三橋 智子; 坂本 直哉
胆道, 28, 1, 73, 80, 日本胆道学会, Mar. 2014
Japanese - Transpapillary dilation of refractory severe biliary stricture or main pancreatic duct by using a wire-guided diathermic dilator (with video).
Kawakami H; Kuwatani M; Kawakubo K; Eto K; Haba S; Kudo T; Abe Y; Kawahata S; Sakamoto N
Gastrointestinal endoscopy, 79, 2, 338, 343, Mosby-elsevier, Feb. 2014, [Peer-reviewed]
English - Is wire-guided selective bile duct cannulation effective for prevention of post-ERCP pancreatitis by all endoscopists?
Kawakami Hiroshi; Isayama Hiroyuki; Maguchi Hiroyuki; Kuwatani Masaki; Kawakubo Kazumichi; Kudo Taiki; Abe Yoko; Kawahata Shuhei; Kubo Kimitoshi; Koike Kazuhiko; Sakamoto Naoya
ENDOSCOPY, 46, 2, 163, 163, Feb. 2014, [Peer-reviewed], [International Magazine]
English - Endoscopic salvage technique for spontaneous dislocation and tumor ingrowth of a partially covered, self-expandable metallic stent after endoscopic ultrasound-guided choledochoduodenostomy
Hiroshi Kawakami; Masaki Kuwatani; Kazumichi Kawakubo; Taiki Kudo; Yoko Abe; Kimitoshi Kubo; Naoya Sakamoto
ENDOSCOPY, 46, E58, E59, Jan. 2014, [Peer-reviewed]
English - Endoscopic ultrasonography-guided antegrade diathermic dilation for the treatment of complete obstruction of a pancreaticogastrostomy
Hiroshi Kawakami; Masaki Kuwatani; Kazumichi Kawakubo; Yoshimasa Kubota; Yoko Abe; Shuhei Kawahata; Kimitoshi Kubo; Naoya Sakamoto
ENDOSCOPY, 46, E517, E518, 2014, [Peer-reviewed]
English - Candy-like sign during endoscopic ultrasound-guided choledochoduodenostomy as an indication of the long distance between the bile duct and duodenal wall.
Kawakami H; Kuwatani M; Kawakubo K; Kudo T; Abe Y; Kubo K; Kubota Y; Sakamoto N
Endoscopy, 46 Suppl 1 UCTN, E406, 7, 2014, [Peer-reviewed] - Endoscopic placement of a fully covered self-expandable metallic stent to treat an arteriobiliary fistula.
Kawakami H; Okamoto M; Kuwatani M; Kubota Y; Kawakubo K; Abe Y; Kawahata S; Kubo K; Sakamoto N
Endoscopy, 46 Suppl 1 UCTN, E566, 7, 2014, [Peer-reviewed] - Endoscopic ultrasonography-guided liver abscess drainage using a dedicated, wide, fully covered self-expandable metallic stent with flared-ends.
Kawakami H; Kawakubo K; Kuwatani M; Kubota Y; Abe Y; Kawahata S; Kubo K; Sakamoto N
Endoscopy, 46 Suppl 1 UCTN, 1, E982, 3, Georg Thieme Verlag, 2014, [Peer-reviewed]
English - Endoscopic ultrasound-guided antegrade diathermic dilation followed by self-expandable metallic stent placement for anastomotic stricture after hepaticojejunostomy (with video).
Kawakami H; Kuwatani M; Sakamoto N
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 26, 1, 121, 122, Jan. 2014, [Peer-reviewed] - Endoscopic ultrasound-guided antegrade diathermic dilation followed by self-expandable metal stent placement for malignant distal biliary stricture.
Kawakami H; Kuwatani M; Kawakubo K; Kudo T; Abe Y; Kubo K; Kubota Y; Sakamoto N
Endoscopy, 46 Suppl 1 UCTN, E328, 9, 2014, [Peer-reviewed] - Endoscopic ultrasound-guided rendezvous procedure for unidentifiable papilla and non-dilated pancreatic duct (with video).
Kawakami H; Kuwatani M; Sakamoto N
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 25, 4, 466, Jul. 2013, [Peer-reviewed] - Preliminary report on a new, fully covered, metal stent designed for the treatment of pancreatic fluid collections
Yamamoto Natsuyo; Isayama Hiroyuki; Kawakami Hiroshi; Sasahira Naoki; Hamada Tsuyoshi; Ito Yukiko; Takahara Naminatsu; Uchino Rie; Miyabayashi Koji; Mizuno Suguru; Kogure Hirofumi; Sasaki Takashi; Nakai Yousuke; Kuwatani Masaki; Hirano Kenji; Tada Minoru; Koike Kazuhiko
GASTROINTESTINAL ENDOSCOPY, 77, 5, 809, 814, May 2013, [Peer-reviewed], [International Magazine]
English, Scientific journal - Hepatobiliary alveolar echinococcosis infiltration of the hepatic hilum diagnosed by endoscopic ultrasonography-guided fine-needle aspiration.
Kawakami H; Kuwatani M; Sakamoto N
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 25, 3, 339, 340, Wiley-Blackwell, May 2013, [Peer-reviewed]
English - New stent exchange technique following endoscopic ultrasound-guided nasobiliary drainage (with video).
Kawakami H; Kuwatani M; Sakamoto N
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 25, 3, 343, 344, Wiley-Blackwell, May 2013, [Peer-reviewed]
English - Human equilibrative nucleoside transporter 1 and Notch3 can predict gemcitabine effects in patients with unresectable pancreatic cancer.
K Eto; H Kawakami; M Kuwatani; T Kudo; Y Abe; S Kawahata; A Takasawa; M Fukuoka; Y Matsuno; M Asaka; N Sakamoto
British journal of cancer, 108, 7, 1488, 94, 16 Apr. 2013, [International Magazine]
English, Scientific journal, BACKGROUND: Pancreatic ductal carcinoma (PDC) is one of the most lethal human carcinomas. Expression patterns of some genes may predict gemcitabine (GEM) treatment efficacy. We examined predictive indicators of survival in GEM-treated patients by quantifying the expression of several genes in pre-treatment endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) samples from patients with PDC. METHODS: The expressions of human equilibrative nucleoside transporter 1 (hENT1), deoxycitidine kinase, ribonucleoside reductase 1, ribonucleoside reductase 2 and Notch3 in EUS-FNA tissue samples from 71 patients with unresectable PDC were quantified using real-time reverse transcription-polymerase chain reactions and examined for correlations with GEM sensitivity. RESULTS: The log-rank test detected no significant differences in overall survival between GEM-treated patients with low and high mRNA levels of all genes examined. However, low Notch3 mRNA expression was significantly associated with longer overall survival in a multivariate analysis for survival (P=0.0094). High hENT1 expression level was significantly associated with a longer time to progression (P=0.039). Interaction tests for GEM administration and hENT1 or Notch3 mRNA expression were statistically significant (P=0.0054 and 0.0047, respectively). CONCLUSION: hENT1 and Notch3 mRNA expressions in EUS-FNA specimens were the key predictive biomarkers of GEM effect and GEM sensitivity in patients with unresectable PDC. - The role of peroral video cholangioscopy in patients with IgG4-related sclerosing cholangitis
Takao Itoi; Terumi Kamisawa; Yoshinori Igarashi; Hiroshi Kawakami; Ichiro Yasuda; Fumihide Itokawa; Yuui Kishimoto; Masaki Kuwatani; Shinpei Doi; Seiichi Hara; Fuminori Moriyasu; Todd H. Baron
JOURNAL OF GASTROENTEROLOGY, 48, 4, 504, 514, Apr. 2013, [Peer-reviewed]
English, Scientific journal - Carbon dioxide insufflation for endoscopic retrograde cholangiopancreatography: is this beneficial for all patients?
Kuwatani M; Kawakami H; Sakamoto N
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 25, 2, 205, Mar. 2013, [Peer-reviewed] - Guidewire cannulation: friend or foe Response
Kawakami Hiroshi; Isayama Hiroyuki; Maguchi Hiroyuki; Kuwatani Masaki; Nakai Yousuke; Kawakubo Kazumichi; Haba Shin; Kudo Taiki; Abe Yoko; Koike Kazuhiko; Sakamoto Naoya
GASTROINTESTINAL ENDOSCOPY, 76, 4, 920, 921, Oct. 2012, [Peer-reviewed] - Endoscopic Nasobiliary Drainage Should be Initially Selected for Preoperative Biliary Drainage in Patients with Perihilar Bile Duct Cancer
Hiroshi Kawakami; Masaki Kuwatani; Kazunori Eto; Taiki Kudo; Eiichi Tanaka; Satoshi Hirano
WORLD JOURNAL OF SURGERY, 36, 9, 2265, 2266, Sep. 2012, [Peer-reviewed]
English - Wire-guided cannulation is not an ideal technique for preventing post-ERCP pancreatitis
Kawakami Hiroshi; Isayama Hiroyuki; Kuwatani Masaki; Eto Kazunori; Kudo Taiki; Abe Yoko; Kawahata Shuhei; Nakai Yousuke; Sasahira Naoki; Koike Kazuhiko; Kato Mototsugu
GASTROINTESTINAL ENDOSCOPY, 76, 1, 223, Jul. 2012, [Peer-reviewed], [International Magazine]
English - Endoscopic ultrasound-guided transmural drainage for pancreatic fistula or pancreatic duct dilation after pancreatic surgery
Manabu Onodera; Hiroshi Kawakami; Masaki Kuwatani; Taiki Kudo; Shin Haba; Yoko Abe; Shuhei Kawahata; Kazunori Eto; Yuya Nasu; Eiichi Tanaka; Satoshi Hirano; Masahiro Asaka
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, 26, 6, 1710, 1717, Jun. 2012, [Peer-reviewed]
English, Scientific journal - COVERED METALLIC STENT FOR ISCHEMIC HILAR BILIARY STRICTURE
Hiroshi Kawakami; Masaki Kuwatani; Kazunori Eto; Taiki Kudo; Masahiro Asaka
DIGESTIVE ENDOSCOPY, 24, 49, 54, May 2012, [Peer-reviewed]
English, Scientific journal - Is Intraductal Papillary Mucinous Neoplasm Really a Risk Factor of Post-endoscopic Retrograde Cholangiopancreatography Pancreatitis after Pancreatic Stenting?
Masaki Kuwatani; Hiroshi Kawakami; Mototsugu Kato
INTERNAL MEDICINE, 51, 10, 1285, 1285, 2012, [Peer-reviewed]
English - Carbon dioxide insufflation during endoscopic retrograde cholangiopancreatography reduces bowel gas volume but does not affect visual analogue scale scores of suffering: a prospective, double-blind, randomized, controlled trial
Masaki Kuwatani; Hiroshi Kawakami; Tsuyoshi Hayashi; Hirotoshi Ishiwatari; Taiki Kudo; Hiroaki Yamato; Nobuyuki Ehira; Shin Haba; Kazunori Eto; Mototsugu Kato; Masahiro Asaka
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, 25, 12, 3784, 3790, Dec. 2011, [Peer-reviewed]
English, Scientific journal - Preoperative biliary drainage for hilar cholangiocarcinoma: which stent should be selected?
Hiroshi Kawakami; Satoshi Kondo; Masaki Kuwatani; Hiroaki Yamato; Nobuyuki Ehira; Taiki Kudo; Kazunori Eto; Shin Haba; Joe Matsumoto; Kentaro Kato; Takahiro Tsuchikawa; Eiichi Tanaka; Satoshi Hirano; Masahiro Asaka
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES, 18, 5, 630, 635, Sep. 2011, [Peer-reviewed]
English, Scientific journal - Three cases of retroperitoneal schwannoma diagnosed by EUS-FNA
Taiki Kudo; Hiroshi Kawakami; Masaki Kuwatani; Nobuyuki Ehira; Hiroaki Yamato; Kazunori Eto; Kanako Kubota; Masahiro Asaka
WORLD JOURNAL OF GASTROENTEROLOGY, 17, 29, 3459, 3464, Aug. 2011, [Peer-reviewed]
English, Scientific journal - EUS-FNA for suspected malignant biliary strictures after negative endoscopic transpapillary brush cytology and forceps biopsy
Yasuhiro Ohshima; Ichiro Yasuda; Hiroshi Kawakami; Masaki Kuwatani; Tsuyoshi Mukai; Takuji Iwashita; Shinpei Doi; Masanori Nakashima; Yoshinobu Hirose; Masahiro Asaka; Hisataka Moriwaki
JOURNAL OF GASTROENTEROLOGY, 46, 7, 921, 928, Jul. 2011, [Peer-reviewed]
English, Scientific journal - Portobiliary fistula: unusual complication of wire-guided cannulation during endoscopic retrograde cholangiopancreatography
H. Kawakami; M. Kuwatani; T. Kudo; N. Ehira; H. Yamato; M. Asaka
ENDOSCOPY, 43, E98, E99, Mar. 2011, [Peer-reviewed]
English, Scientific journal - Endoscopic nasobiliary drainage is the most suitable preoperative biliary drainage method in the management of patients with hilar cholangiocarcinoma
Hiroshi Kawakami; Masaki Kuwatani; Manabu Onodera; Shin Haba; Kazunori Eto; Nobuyuki Ehira; Hiroaki Yamato; Taiki Kudo; Eiichi Tanaka; Satoshi Hirano; Satoshi Kondo; Masahiro Asaka
JOURNAL OF GASTROENTEROLOGY, 46, 2, 242, 248, Feb. 2011, [Peer-reviewed]
English, Scientific journal - IgG4-related sclerosing cholangitis and autoimmune pancreatitis: Histological assessment of biopsies from Vater's ampulla and the bile duct
Hiroshi Kawakami; Yoh Zen; Masaki Kuwatani; Kazunori Eto; Shin Haba; Hiroaki Yamato; Keisuke Shinada; Kanako Kubota; Masahiro Asaka
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 25, 10, 1648, 1655, Oct. 2010, [Peer-reviewed]
English, Scientific journal - Cystic pancreatic neuroendocrine tumors
河上 洋; 桒谷 将城; 羽場 真; 江藤 和範; 小野寺 学; 近藤 哲; 浅香 正博
肝胆膵画像, 12, 4, 489, 500, 株式会社医学書院, 15 Jul. 2010 - NEEDLE KNIFE SPHINCTEROTOMY FOR AN IMPACTED AMPULLARY STONE WITH DIFFICULT SELECTIVE BILIARY CANNULATION
Hiroshi Kawakami; Masaki Kuwatani; Manabu Onodera; Shin Haba; Masahiro Asaka
DIGESTIVE ENDOSCOPY, 22, S107, S110, Jul. 2010, [Peer-reviewed]
English, Scientific journal - Osteonecrosis and Panniculitis as Life-Threatening Signs
Masaki Kuwatani; Hiroshi Kawakami; Yosuke Yamada
Clinical Gastroenterology and Hepatology, 8, 5, e52, e53, Elsevier BV, May 2010, [Peer-reviewed]
English, Scientific journal - Endoscopic retrograde cholangiography versus peroral cholangioscopy to evaluate intraepithelial tumor spread in biliary cancer
H. Kawakami; M. Kuwatani; K. Etoh; S. Haba; H. Yamato; K. Shinada; Y. Nakanishi; E. Tanaka; S. Hirano; S. Kondo; K. Kubota; M. Asaka
ENDOSCOPY, 41, 11, 959, 964, Nov. 2009, [Peer-reviewed]
English, Scientific journal - A malignant pancreatic neuro-endocrine tumor with intraductal growth within the main pancreatic duct and tumor thrombus within the splenic vein
ETO Kazunori; KAWAKAMI Hiroshi; KUWATANI Masaki; HABA Shin; HIRANO Satoshi; KONDO Satoshi; KUBOTA Kanako; MATUNO Yoshihiro; HIRAYAMA Atushi; GOTOUDA Yuuko; ASAKA Masahiro
Suizo, 24, 4, 537, 547, 25 Aug. 2009
Japanese - A case of adenomyomatous hyperplasia in the distal bile duct
HABA Shin; KAWAKAMI Hiroshi; KUWATANI Masaki; ETO Kazunori; KONDO Satoshi; ASAKA Masahiro
Tando, 23, 2, 181, 187, Japan Biliary Association, 31 May 2009
Japanese, The patient was a 75-year-old woman who was referred to our hospital for detailed examination of liver dysfunction. Abdominal CT and EUS revealed a mass lesion in the distal bile duct, while ERC showed a filling defect. The patient was preoperatively diagnosed with papillary distal bile duct carcinoma, and surgical resection was performed. Macroscopic findings for the resected specimen included a papillary tumor presenting with redness in the distal bile duct. Histologically, mildly atypical gland and hyperplasia of muscle fibers and fibrous tissue were observed. Based on these findings, a final diagnosis of adenomyomatous hyperplasia was made. Benign tumors rarely occur in the bile duct, and among them, adenomyomatous hyperplasia is particularly rare. As no characteristic findings on diagnostic imaging have been elucidated for this disease, accurate preoperative diagnosis is currently difficult. Detailed investigation through accumulation of cases is necessary in the future. - Sonazoid造影下超音波検査が有用であった膵・胆道腫瘤性病変
桑谷 将城; 河上 洋; 西田 睦; 江藤 和範; 羽場 真; 小野寺 祐也; 浅香 正博
日本消化器病学会雑誌, 106, 臨増総会, A385, A385, (一財)日本消化器病学会, Mar. 2009
Japanese - Pancreatic Carcinoma Associated with Portal Vein Tumor Thrombus: Three Case Reports
Hiroaki Yamato; Hiroshi Kawakami; Masaki Kuwatani; Keisuke Shinada; Satoshi Kondo; Kanako Kubota; Masahiro Asaka
INTERNAL MEDICINE, 48, 3, 143, 150, 2009, [Peer-reviewed]
English, Scientific journal - Modalities for Evaluating Chemotherapeutic Efficacy and Survival Time in Patients with Advanced Pancreatic Cancer: Comparison between FDG-PET, CT, and Serum Tumor Markers
Masaki Kuwatani; Hiroshi Kawakami; Kazunori Eto; Shin Haba; Tohru Shiga; Nagara Tamaki; Masahiro Asaka
INTERNAL MEDICINE, 48, 11, 867, 875, 2009, [Peer-reviewed]
English, Scientific journal - Pancreatic metastasis from small cell carcinoma of the uterine cervix demonstrated by endoscopic ultrasonography-guided fine needle aspiration.
Kuwatani M; Kawakami H; Asaka M; Marukawa K; Matsuno Y; Hosaka M
Diagnostic cytopathology, 36, 11, 840, 842, Nov. 2008, [Peer-reviewed] - 【いま,胆道鏡検査 PTCS・POCSを見直す】胆管癌に対する胆道鏡診断の意義と限界 POCS
河上 洋; 桑谷 将城; 大和 弘明; 品田 恵佐; 江藤 和範; 羽場 真; 中西 喜嗣; 近藤 哲; 浅香 正博
肝胆膵画像, 10, 5, 393, 397, (株)医学書院, Sep. 2008
Japanese - 肝移植後膵液瘻による合併症に対し複合的IVRが奏功した1例
長谷川 悠; 阿保 大介; 佐原 祐介; 白土 博樹; 清水 匡; 嶋村 剛; 古川 博之; 桑谷 将城; 河上 洋
IVR: Interventional Radiology, 23, 3, 316, 316, (一社)日本インターベンショナルラジオロジー学会, Jul. 2008
Japanese - Three cases of groove pancreatic carcinoma in which endoscopic ultrasonography was useful for diagnosis before surgery
Masaki Kuwatani; Hiroshi Kawakami; Hiroaki Yamato; Keisuke Shinada; Eiichi Tanaka; Satoshi Hirano; Satoshi Kondoh; Tomoo Itoh; Masahiro Asaka
Japanese Journal of Gastroenterology, 105, 7, 1061, 1069, 2008, [Peer-reviewed]
Japanese, Scientific journal - Autoimmune pancreatitis associated with hemorrhagic pseudocysts: a case report and literature review.
Kawakami H; Kuwatani M; Shinada K; Yamato H; Hirano S; Kondo S; Yonemori A; Itoh T; Matsuno Y; Asaka M
Internal medicine (Tokyo, Japan), 47, 7, 603, 608, The Japanese Society of Internal Medicine, 2008, [Peer-reviewed]
English, Autoimmune pancreatitis (AIP) is a new category of pancreatic diseases. AIP associated with pseudocysts is rare; only 8 cases have been reported in the literature. A 63-year-old man was admitted to our department because of upper left abdominal pain and back pain. Various imaging studies demonstrated swelling of the tail of the pancreas with hemorrhagic pseudocysts. The patient underwent a surgical operation. A pancreatogram of the specimen revealed total occlusion of the main pancreatic duct in the tail of the pancreas. Histopathological examination revealed that it was AIP with hemorrhagic pseudocysts. - Pancreatic metastasis from renal cell carcinoma with intraportal tumor thrombus.
Kawakami H; Kuwatani M; Yamato H; Shinada K; Hirano S; Kondo S; Yonemori A; Matsuno Y; Asaka M
Internal medicine (Tokyo, Japan), 47, 22, 1967, 1970, The Japanese Society of Internal Medicine, 2008, [Peer-reviewed]
English, A 68-year-old woman with a history of renal cell carcinoma (RCC) resected curatively 12 years previously was admitted to our department for scrutiny of pancreatic tumors. Various imaging studies demonstrated heterogeneously well-enhanced masses in the head and tail of the pancreas. The well-enhanced mass in the head of the pancreas was connected with the tumor thrombus in the portal vein. To differentially diagnose the multiple pancreatic lesions, we performed endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNAB). Histopathologic findings of the EUS-FNAB specimens were similar to those of the renal clear cell carcinoma previously resected. The patient underwent a surgical operation with segmental resection of the portal vein with the preoperative diagnosis of RCC metastasis to the pancreas with intraportal growth. Histopathological examination of the resected specimen revealed that the masses in the pancreas were multiple pancreatic metastases with intraportal tumor thrombus of RCC. The pancreas is a rare target for metastasis. This is a rare case of pancreatic metastasis from RCC with intraportal extension, and is the first preoperatively definitely diagnosed case using EUS-FNAB. - Villous adenoma arising in choledochocele
Hiroshi Kawakami; Masaki Kuwatani; Manabu Onodera; Masahiro Asaka; Satoshi Hirano; Satoshi Kondo
GASTROINTESTINAL ENDOSCOPY, 66, 6, 1231, 1232, Dec. 2007, [Peer-reviewed]
English - 肝外胆管にまで広範囲に粘膜下壁内進展した肝内胆管癌の1例
小野寺 学; 河上 洋; 桑谷 将城; 上林 実; 平野 聡; 近藤 哲; 中西 喜嗣; 伊藤 智雄; 浅香 正博
胆道, 21, 4, 527, 533, 日本胆道学会, Oct. 2007
Japanese, 73歳男性。患者は近医にて血清19-9値の上昇、腹部CT上の肝腫瘤性病変を指摘され、著者らの施設へ紹介となった。入院時、肝・胆道系酵素の上昇を認め、腹部CT・MRCP・IDUS・内視鏡的逆行性胆管造影検査にて左肝内胆管癌と上中部胆管癌の重複癌が疑われた。肝左葉尾状葉切除、肝外胆管合併切除、門脈楔状切除、右肝動脈切除、再建術を行なった結果、病理組織学的に本症例は肝外胆管まで広範囲に粘膜下壁内進展した胆管浸潤型肝内胆管癌と最終的に診断された。術後は経過良好で、現在、1年2ヵ月経過で無再発生存中である。 - Primary acinar cell carcinoma of the ampulla of Vater
Hiroshi Kawakami; Masaki Kuwatani; Manabu Onodera; Satoshi Hirano; Satoshi Kondo; Yoshitsugu Nakanishi; Tomoo Itoh; Masahiro Asaka
JOURNAL OF GASTROENTEROLOGY, 42, 8, 694, 697, Aug. 2007, [Peer-reviewed]
English, Scientific journal - G-CSF産生膵管癌の1例
河上 洋; 桑谷 将城; 藤谷 好弘; 上林 実; 小西 康平; 牧山 裕顯; 橋野 聡; 久保田 佳奈子; 伊藤 智雄; 浅香 正博
日本消化器病学会雑誌, 104, 2, 233, 238, (一財)日本消化器病学会, Feb. 2007
Japanese - [A case of granulocyte-colony stimulating factor producing ductal adenocarcinoma of the pancreas].
Kawakami H; Kuwatani M; Fujiya Y; Uebayashi M; Konishi K; Makiyama H; Hashino S; Kubota K; Itoh T; Asaka M
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 104, 2, 233, 238, 2, Feb. 2007, [Peer-reviewed], [Domestic magazines]
Japanese, Scientific journal, We report a case of pancreatic ductal adenocarcinoma producing granulocyte-colony stimulating factor (G-CSF). A 56-year-old Japanese man was admitted to our hospital with back pain and high fever. An abdominal CT scan revealed masses in the pancreatic body to the tail, and both lobes of the liver. A biopsy specimen of the hepatic tumor demonstrated metastatic poorly differentiated adenocarcinoma. We administered oral S-1 in combination with gemcitabine. However, his general condition gradually worsened, and a high serum level of G-CSF persisted. He died 135 days after admission. The diagnosis of autopsy was pancreatic ductal adenocarcinoma. Immunohistochemical staining showed the presence of G-CSF in tumor cells. The final diagnosis was G-CSF-producing pancreatic carcinoma. - Two Cases of Acinar Cell Carcinoma
河上 洋; 桒谷 将城; 小野寺 学; 北上 英彦; 平野 聡; 近藤 哲; 伊藤 智雄; 浅香 正博
消化器画像, 9, 1, 47, 55, 株式会社医学書院, 15 Jan. 2007 - Autoimmune Pancreatitis with Retroperitoneal Fibrosis Which Responded to Steroid Therapy but Was Complicated with Refractory Renal Dysfunction
Masaki Kuwatani; Hiroshi Kawakami; Hiroaki Makiyama; Manabu Onodera; Kakuya Matsumoto; Gakuyo Karasawa; Masahiro Asaka
INTERNAL MEDICINE, 46, 18, 1557, 1564, 2007, [Peer-reviewed]
English, Scientific journal - Pancreatic Endocrine Tumors with Intraductal Growth into the Main Pancreatic Duct and Tumor Thrombus within the Portal Vein: A Case Report and Review of the Literature
Hiroshi Kawakami; Masaki Kuwatani; Satoshi Hirano; Satoshi Kondo; Yoshitsugu Nakanishi; Tomoo Itoh; Masahiro Asaka
INTERNAL MEDICINE, 46, 6, 273, 277, 2007, [Peer-reviewed]
English - Primary cholesterol hepatolithiasis associated with cholangiocellular carcinoma: A case report and literature review
Hiroshi Kawakami; Masaki Kuwatani; Manabu Onodera; Satoshi Hirano; Satoshi Kondo; Yoshitsugu Nakanishi; Tomoo Itoh; Masahiro Asaka
INTERNAL MEDICINE, 46, 15, 1191, 1195, 2007, [Peer-reviewed]
English - 門脈内腫瘍栓および膵管内腫瘍進展を伴った悪性膵内分泌腫瘍の1例
桑谷 将城; 河上 洋; 斉藤 克憲; 平野 聡; 近藤 哲; 中西 喜嗣; 伊藤 智雄; 浅香 正博
日本消化器病学会雑誌, 103, 臨増大会, A1009, A1009, (一財)日本消化器病学会, Sep. 2006
Japanese - Modulation of acute graft-versus-host disease and chimerism after adoptive transfer of in vitro-expanded invariant V alpha 14 natural killer T cells
Masaki Kuwatani; Yoshinori Ikarashi; Akira Iizuka; Chihiro Kawakami; Gary Quinn; Yuji Heike; Mitsuzi Yoshida; Masahiro Asaka; Yoichi Takaue; Hiro Wakasugi
IMMUNOLOGY LETTERS, 106, 1, 82, 90, Jul. 2006, [Peer-reviewed]
English, Scientific journal - misdiagnosisに学ぶ -術前診断-下部胆管癌疑い
河上 洋; 上林 実; 桒谷 将城; 平野 聡; 近藤 哲; 浅香 正博
消化器画像, 8, 2, 133, 137, 株式会社医学書院, 15 Mar. 2006 - An irradiation-free nonmyeloablative bone marrow transplantation model: Importance of the balance between donor T-cell number and the intensity of conditioning
M Kuwatani; Y Ikarashi; S Mineishi; M Asaka; H Wakasugi
TRANSPLANTATION, 80, 9, 1145, 1152, Nov. 2005, [Peer-reviewed]
English, Scientific journal - 30) 5Fr内胸動脈造影用カテーテルをガイデングカテーテルとして用いた,右冠動脈ステント内再狭窄の一例
桑谷 将城; 中川 泉; 陰山 研; 鈴木 善之; 富田 籌夫
64, 736, 社団法人日本循環器学会, 20 Apr. 2000
Japanese
- PLASTIC STENTS VS. LUMEN-APPOSING METAL STENT FOR ENDOSCOPIC ULTRASOUND-GUIDED DRAINAGE OF PANCREATIC PSUEDOCYSTS: A MULTICENTER, RANDOMISED CONTROLLED, NON-INFERIORITY TRIAL (WONDER-02)
Tomotaka Saito; Takeshi Ogura; Nao Fujimori; Hiroshi Ohyama; Kazuyuki Matsumoto; Nobuhiko Hayashi; Toshio Fujisawa; Atsuhiro Masuda; Masaki Kuwatani; Shinpei Doi; Mamoru Takenaka; Keisuke Iwata; Hideyuki Shiomi; Hirofumi Kogure; Tadahisa Inoue; Saburo Matsubara; Shinichi Hashimoto; Hideki Kamada; Masayuki Kitano; Toshiyasu Shiratori; Tsuyoshi Hamada; Kosuke Kashiwabara; Saori Ueno; Atsushi Okuda; Kazuhide Matsumoto; Keijiro Ueda; Koji Takahashi; Motoyasu Kan; Ryosuke Sato; Takuji Iwashita; Sho Takahashi; Masahiro Tsujimae; Ryo Sugiura; Nobuhiro Katsukura; Shunsuke Omoto; Yuhei Iwasa; Ryota Nakano; Kei Saito; Rena Kitano; Kentaro Suda; Makoto Hinokuchi; Ryota Nakabayashi; Takashi Tamura; So Nakaji; Akinori Maruta; Tsuyoshi Mukai; Reiko Yamada; Hiroyuki Isayama; Ichiro Yasuda; Yousuke Nakai, GASTROENTEROLOGY, 169, 1, S2084, S2085, 03 May 2025
English, Summary international conference - IMMEDIATE NECROSECTOMY VS. DRAINAGE-ORIENTED STEP-UP APPROACH AFTER ENDOSCOPIC ULTRASOUND-GUIDED DRAINAGE OF WALLED-OFF NECROSISdSUBGROUP ANALYSES OF A MULTICENTER RANDOMISED CONTROLLED TRIAL (WONDER-01)
Tomotaka Saito; Toshio Fujisawa; Takeshi Ogura; Masaki Kuwatani; Hiroshi Ohyama; Mamoru Takenaka; Shinpei Doi; Keisuke Iwata; Shinichi Hashimoto; Hideki Kamada; Takuji Iwashita; Hideyuki Shiomi; Atsuhiro Masuda; Saburo Matsubara; Nobuhiko Hayashi; Akinori Maruta; Hirofumi Kogure; Tadahisa Inoue; Reiko Yamada; Toshiyasu Shiratori; Tsuyoshi Hamada; Saori Ueno; Atsushi Okuda; Sho Takahashi; Ryo Sugiura; Kazumichi Kawakubo; Koji Takahashi; Motoyasu Kan; Shunsuke Omoto; Tomohiro Yamazaki; Nobuhiro Katsukura; Mitsuru Okuno; Makoto Hinokuchi; Daisuke Namima; Shinya Uemura; Ryota Nakano; Masahiro Tsujimae; Arata Sakai; Kentaro Suda; Kensaku Yoshida; Kei Saito; Rena Kitano; Kenji Nose; So Nakaji; Tsuyoshi Mukai; Kazunari Nakahara; Kenji Chinen; Hiroyuki Isayama; Ichiro Yasuda; Yousuke Nakai, GASTROINTESTINAL ENDOSCOPY, 101, 5, May 2025
English, Summary international conference - Risk factors of post-ERCP pancreatitis from the viewpoint of patient characteristics
桑谷将城; 野澤俊一郎; 小田総一郎; 白鳥翔也; 米村洋輝; 杉浦諒; 川久保和道; 坂本直哉, 肝胆膵, 90, 4, 2025 - 悪性肝門部胆道閉塞に対する初期ドレナージとしての内視鏡的胆道内ステント留置術と内視鏡的経鼻胆道ドレナージ術の比較(Comparison of endoscopic biliary inside stenting with endoscopic nasobiliary drainage as the initial drainage for malignant hilar biliary obstruction)
杉浦 諒; 桑谷 将城; 坂本 直哉, 胆道, 38, 3, 383, 383, Sep. 2024
(一社)日本胆道学会, English - 肝門部悪性胆道閉塞に対する非被覆自己拡張型金属ステント(YABUSAME)の有効性(Efficacy of Uncovered Self-Expandable Metal Stent (YABUSAME) for Malignant Hilar Biliary Obstruction: A Multicenter Prospective Study)
池澤 賢治; 竹下 宏太郎; 肱岡 範; 高田 良司; 奥田 篤; 小倉 健; 桑谷 将城; 藤森 尚; 土井 晋平; 遠藤 壮登; 松原 三郎; 山田 玲子; 奥坂 拓志, 胆道, 38, 3, 383, 383, Sep. 2024
(一社)日本胆道学会, English - 胆道癌患者における術前骨格筋量減少の危険因子解析
杉浦 諒; 桑谷 将城; 坂本 直哉; 小田 総一郎; 白鳥 翔也; 野澤 俊一郎; 米村 洋輝; 川久保 和道, 胆道, 38, 3, 461, 461, Sep. 2024
(一社)日本胆道学会, Japanese - 膵IPMN長期経過観察例の評価 IPMN患者における骨格筋量減少の膵発癌に与える影響
小田 総一郎; 川久保 和道; 白鳥 翔也; 野澤 俊一郎; 米村 洋輝; 岸 法磨; 杉浦 諒; 桑谷 将城; 坂本 直哉, 膵臓, 39, 3, A308, A308, Jul. 2024
(一社)日本膵臓学会, Japanese - 持続可能な膵がん教室にするための現状と課題
田辺 睦子; 中村 透; 寺澤 孝男; 伊藤 元; 白岩 剛; 川本 泰之; 桑谷 将城; 加藤 徳雄; 浅野 賢道; 山田 眞佐美; 池澤 賢治; 安保 義恭; 潟沼 朗生; 平手 大輔, 膵臓, 39, 3, A388, A388, Jul. 2024
(一社)日本膵臓学会, Japanese - 膵管狭窄/拡張に対する内視鏡的逆行性膵管造影下ブラシ細胞診と連続膵液細胞診の診断能の比較
杉浦 諒; 桑谷 将城; 坂本 直哉, Gastroenterological Endoscopy, 66, Suppl.1, 1016, 1016, Apr. 2024
(一社)日本消化器内視鏡学会, Japanese - 【患者さんからよく尋ねられる内科診療のQuestion】(第8章)肝・胆・膵 [39歳女性,胆嚢ポリープ]健康診断で胆嚢ポリープと指摘されて,経過観察と言われましたが,手術は必要ないでしょうか?
桑谷 将城, 内科, 133, 4, 865, 867, Apr. 2024
(株)南江堂, Japanese - 超音波内視鏡下組織採取後の穿刺経路腫瘍細胞播種に関する全国調査
北野 雅之; 吉田 真誠; 蘆田 玲子; 喜多 絵美里; 潟沼 朗生; 糸井 隆夫; 三方 林太郎; 西川 健一郎; 松林 宏行; 高山 敬子; 加藤 博也; 竹中 完; 植木 亨; 川嶌 洋平; 中井 陽介; 橋元 慎一; 重川 稔; 根引 浩子; 津村 英隆; 岡部 義信; 良沢 昭銘; 原田 宜幸; 美登路 昭; 佐々木 民人; 保田 宏明; 三浦 夏希; 池本 哲也; 小澤 栄介; 塩路 和彦; 山口 厚; 奥薗 徹; 森山 一郎; 久居 弘幸; 藤田 光一; 後藤 拓磨; 白幡 名香雄; 岩田 恵典; 岡部 純弘; 原 和生; 橋本 裕輔; 桑谷 将城; 伊佐山 浩通; 藤森 尚; 正宗 淳; 幡丸 景一; 下川 敏雄; 岡崎 和一; 竹山 宜典; 山上 裕機; 日本膵臓学会臨床研究推進委員会, Gastroenterological Endoscopy, 66, 3, 312, 326, Mar. 2024
(一社)日本消化器内視鏡学会, Japanese - Interventional EUSの現状と展開 小病変の膵神経内分泌腫瘍(G1)に対する超音波内視鏡下エタノール注入療法の有効性と安全性の検証 多施設共同前向き介入研究
向井 俊太郎; 松本 和幸; 加藤 博也; 山崎 辰洋; 北野 雅之; 蘆田 玲子; 桑谷 将城; 原 和生; 竹中 完; 糸井 隆夫, 日本消化器病学会雑誌, 121, 臨増総会, A151, A151, Mar. 2024
(一財)日本消化器病学会, Japanese - 膵癌早期診断の試み 十二指腸液中のメタボローム解析による膵良悪性疾患の鑑別
岸 法磨; 桑谷 将城; 小田 総一郎; 白鳥 翔也; 米村 洋輝; 野澤 俊一郎; 杉浦 諒; 川久保 和道; 坂本 直哉, 日本消化器病学会雑誌, 121, 臨増総会, A221, A221, Mar. 2024
(一財)日本消化器病学会, Japanese - 超音波内視鏡下組織採取後の穿刺経路腫瘍細胞播種に関する全国調査
北野 雅之; 吉田 真誠; 蘆田 玲子; 喜多 絵美里; 潟沼 朗生; 糸井 隆夫; 三方 林太郎; 西川 健一郎; 松林 宏行; 高山 敬子; 加藤 博也; 竹中 完; 植木 亨; 川嶌 洋平; 中井 陽介; 橋元 慎一; 重川 稔; 根引 浩子; 津村 英隆; 岡部 義信; 良沢 昭銘; 原田 宜幸; 美登路 昭; 佐々木 民人; 保田 宏明; 三浦 夏希; 池本 哲也; 小澤 栄介; 塩路 和彦; 山口 厚; 奥薗 徹; 森山 一郎; 久居 弘幸; 藤田 光一; 後藤 拓磨; 白幡 名香雄; 岩田 恵典; 岡部 純弘; 原 和生; 橋本 裕輔; 桑谷 将城; 伊佐山 浩通; 藤森 尚; 正宗 淳; 幡丸 景一; 下川 敏雄; 岡崎 和一; 竹山 宜典; 山上 裕機; 日本膵臓学会臨床研究推進委員会, Gastroenterological Endoscopy, 66, 3, 312, 326, Mar. 2024
(一社)日本消化器内視鏡学会, Japanese - 十二指腸液中のメタボローム解析による膵良悪性疾患の鑑別
岸法磨; 桑谷将城; 小田総一郎; 白鳥翔也; 米村洋輝; 野澤俊一郎; 杉浦諒; 川久保和道; 坂本直哉, 日本消化器病学会雑誌(Web), 121, 2024 - 小病変の膵神経内分泌腫瘍(G1)に対する超音波内視鏡下エタノール注入療法の有効性と安全性の検証:多施設共同前向き介入研究
向井俊太郎; 松本和幸; 加藤博也; 山崎辰洋; 北野雅之; 蘆田玲子; 桑谷将城; 原和生; 竹中完; 糸井隆夫, 日本消化器病学会雑誌(Web), 121, 2024 - 持続可能な膵がん教室にするための現状と課題
田辺睦子; 中村透; 寺澤孝男; 伊藤元; 白岩剛; 川本泰之; 桑谷将城; 加藤徳雄; 浅野賢道; 山田眞佐美; 池澤賢治; 安保義恭; 潟沼朗生; 平手大輔, 膵臓(Web), 39, 3, 2024 - IPMN患者における骨格筋量減少の膵発癌に与える影響
小田総一郎; 川久保和道; 白鳥翔也; 野澤俊一郎; 米村洋輝; 岸法磨; 杉浦諒; 桑谷将城; 坂本直哉, 膵臓(Web), 39, 3, 2024 - 膵管狭窄/拡張に対する内視鏡的逆行性膵管造影下ブラシ細胞診と連続膵液細胞診の診断能の比較
杉浦諒; 桑谷将城; 坂本直哉, Gastroenterological Endoscopy (Web), 66, Supplement1, 2024 - 硝子化により非典型的な所見を呈した膵神経内分泌腫瘍の1例
白鳥翔也; 杉浦諒; 小田総一郎; 野澤俊一郎; 米村洋輝; 岸法磨; 川久保和道; 桑谷将城; 坂本直哉; 松井あや; 平野聡; 頼永聡子; 三橋智子, 日本消化器病学会北海道支部例会・日本消化器内視鏡学会北海道支部例会プログラム・抄録集, 134th-128th, 2024 - Efficacy of Uncovered Self-Expandable Metal Stent (YABUSAME) for Malignant Hilar Biliary Obstruction: A Multicenter Prospective Study
池澤賢治; 竹下宏太郎; 竹下宏太郎; 肱岡範; 高田良司; 奥田篤; 小倉健; 桑谷将城; 藤森尚; 土井晋平; 遠藤壮登; 松原三郎; 山田玲子; 奥坂拓志, 胆道(Web), 38, 3, 2024 - 胆道癌患者における術前骨格筋量減少の危険因子解析
杉浦諒; 桑谷将城; 坂本直哉; 小田総一郎; 白鳥翔也; 野澤俊一郎; 米村洋輝; 川久保和道, 胆道(Web), 38, 3, 2024 - IPMN患者における骨格筋量減少の長期予後に与える影響
小田総一郎; 川久保和道; 白鳥翔也; 野澤俊一郎; 米村洋輝; 岸法磨; 杉浦諒; 桑谷将城; 坂本直哉, 日本消化器病学会雑誌(Web), 121, 2024 - 胆管Fully covered self-expandable metal stent留置併用膵管plastic stent閉塞に起因した膵液瘻の1例
米村洋輝; 杉浦諒; 白鳥翔也; 小田総一郎; 野澤俊一郎; 川久保和道; 桑谷将城; 坂本直哉, 日本消化器病学会北海道支部例会・日本消化器内視鏡学会北海道支部例会プログラム・抄録集, 135th-129th, 2024 - Endoscopic Diagnostic Approach for Obstructive Jaundice
桑谷将城; 米村洋輝; 野澤俊一郎; 岸法磨; 杉浦諒; 川久保和道; 坂本直哉, 臨床消化器内科, 38, 13, 1625, 1631, Nov. 2023
(株)日本メディカルセンター, Japanese - 胆道疾患に対するInterventional EUSの現在、およびX線透視の活用—特集 低被ばく進むX線撮影装置
川久保 和道; 桒谷 将城; 杉浦 諒; 永井 孝輔; 岸 法磨; 米村 洋輝; 野澤 俊一郎; 坂本 直哉, 映像情報medical : a monthly journal of medical imaging and information, 55, 2, 12, 16, Feb. 2023
産業開発機構映像情報メディカル編集部, Japanese - A single-center retrospective study on the clinical background and chemotherapy outcomes of patients with metastatic pancreatic cancer in the elderly and non-elderly
川本泰之; 川本泰之; 原田一顕; 山村貴洋; 山村貴洋; 渡辺亮介; 中村赳晶; 中村赳晶; 結城敏志; 桑谷将城; 桑谷将城; 小松嘉人; 坂本直哉, 日本高齢消化器病学会誌, 25, 2, 2023 - 悪性胆道狭窄に対する胆汁を用いたliquid biopsyの検討
永井孝輔; 桑谷将城; 坂本直哉, 日本消化器病学会雑誌(Web), 120, 2023 - Nakazawa分類Type2/3/4IgG4関連硬化性胆管炎の臨床的特徴
杉浦諒; 桑谷将城; 野澤俊一郎; 米村洋輝; 岸法磨; 永井孝輔; 川久保和道; 坂本直哉, 日本消化器病学会雑誌(Web), 120, 2023 - Follow-up survey on HBOC cases in our hospital
佐々木佑菜; 三田村卓; 三田村卓; 松本隆児; 桑谷将城; 細田充主; 安部崇重; 柴田有花; 松島理明; 松島理明; 矢部一郎; 矢部一郎; 山田崇弘, 日本遺伝カウンセリング学会誌, 44, 2, 2023 - ERCP後膵炎の発症に関するIL-6アンプ関連遺伝子の解析
古川龍太郎; 桑谷将城; 岸法磨; 永井孝輔; 平田甫; 瀧新悠之介; 川久保和道; 村上正晃; 平野聡; 坂本直哉, 膵臓(Web), 38, 3, 2023 - Web形式で行う膵がん教室の現状と課題
白岩剛; 中村透; 田辺睦子; 寺澤孝男; 伊藤元; 川本泰之; 桑谷将城; 加藤徳雄; 浅野賢道; 山田眞佐美; 池澤賢治; 秋田裕史; 金丸道太郎; 潟沼朗生; 潟沼朗生; 平野聡, 膵臓(Web), 38, 3, 2023 - 膵管狭窄病変に対する膵液中cell-free DNAを用いた膵液liquid biopsy
永井孝輔; 桑谷将城; 野澤俊一郎; 米村洋輝; 岸法磨; 杉浦諒; 川久保和道, 膵臓(Web), 38, 3, 2023 - 急性膵炎後被包化壊死に対するリスク層別化分類(QNI分類)の検討
野澤俊一郎; 桑谷将城; 坂本直哉, Gastroenterological Endoscopy (Web), 65, Supplement1, 2023 - 良性胆管狭窄に対する円錐らせん型胆管ステント留置の有用性
永井孝輔; 桑谷将城; 坂本直哉, Gastroenterological Endoscopy (Web), 65, Supplement1, 2023 - 急性胆管炎合併急性胆嚢炎に対する経鼻胆道ドレナージチューブの新規使用法が有効であった1例
岸法磨; 桑谷将城; 野澤俊一郎; 米村洋輝; 永井孝輔; 杉浦諒; 川久保和道; 坂本直哉, 日本消化器病学会北海道支部例会・日本消化器内視鏡学会北海道支部例会プログラム・抄録集, 132nd-126th, 2023 - 膵周囲液体貯留(PFC)に対するLumen apposing metal stent(LAMS)を用いた経消化管的超音波内視鏡下ドレナージの臨床成績
米村洋輝; 桑谷将城; 野澤俊一郎; 岸法磨; 永井孝輔; 杉浦諒; 川久保和道; 坂本直哉, 日本消化器病学会北海道支部例会・日本消化器内視鏡学会北海道支部例会プログラム・抄録集, 132nd-126th, 2023 - 非切除十二指腸乳頭部癌症例における胆管ステント機能不全の危険因子解析:多施設共同後方視的観察研究
杉浦諒; 桑谷将城; 金俊文; 松本隆祐; 池田裕貴; 佐野逸紀; 平田幸司; 吉田真誠; 柾木喜晴; 小野道洋; 平田甫; 大和弘明; 小野寺学; 中村英明; 多谷容子; 江平宣起; 中島正人; 潟沼朗生; 杉浦諒; 桑谷将城; 金俊文; 松本隆祐; 池田裕貴; 佐野逸紀; 平田幸司; 吉田真誠; 柾木喜晴; 小野道洋; 平田甫; 大和弘明; 小野寺学; 中村英明; 多谷容子; 江平宣起; 中島正人; 潟沼朗生, Gastroenterological Endoscopy (Web), 65, Supplement2, 2023 - Malignant potentialを有するSolid-pseudo papillary neoplasmの1例
岸法磨; 桑谷将城; 野澤俊一郎; 米村洋輝; 永井孝輔; 杉浦諒; 川久保和道; 坂本直哉, 日本消化器画像診断研究会プログラム・抄録集, 77th, 2023 - 十二指腸液中のメタボローム解析による胆道良悪性疾患の鑑別
岸法磨; 桑谷将城; 野澤俊一郎; 米村洋輝; 杉浦諒; 川久保和道; 坂本直哉, 胆道(Web), 37, 3, 2023 - 胆膵疾患の外科的切除後合併症におけるバルーン内視鏡補助下胆道治療の現状
米村洋輝; 桑谷将城; 野澤俊一郎; 岸法磨; 永井孝輔; 杉浦諒; 川久保和道; 坂本直哉, 胆道(Web), 37, 3, 2023 - 実臨床における切除不能進行・再発胆道癌に対するGEM+CDDP+S-1療法(GCS)と三剤逐次投与の治療成績に関する検討
川本泰之; 川本泰之; 原田一顕; 坂本直哉; 中村赳晶; 金子志帆; 石田浩一; 結城敏志; 桑谷将城; 小松嘉人, 胆道(Web), 37, 3, 2023 - 膵空腸吻合部狭窄に対する超音波内視鏡とバルーン補助下内視鏡を用いた2-step治療
瀧新悠之介; 瀧新悠之介; 桑谷将城; 永井孝輔; 川久保和道; 坂本直哉, 日本消化器病学会北海道支部例会・日本消化器内視鏡学会北海道支部例会プログラム・抄録集, 133rd-127th, 2023 - 多発遠隔転移を伴い,画像上認識困難であった小膵癌の1例
小田総一郎; 高木智史; 中西勝也; 桑谷将城; 坂本直哉, 日本消化器病学会北海道支部例会・日本消化器内視鏡学会北海道支部例会プログラム・抄録集, 133rd-127th, 2023 - 肝門部領域胆管癌の術前超音波内視鏡検査の臨床的意義
杉浦諒; 桑谷将城; 坂本直哉, 胆道(Web), 37, 3, 2023 - 閉塞性黄疸のドレナージ,何を考える?—特集 胆道・膵疾患を診る : 早期診断・早期治療のために ; 胆膵実地診療のコツ
桒谷 将城; 岸 法磨; 永井 孝輔; 川久保 和道; 坂本 直哉, 内科 = Internal medicine : 臨床雑誌, 130, 1, 41, 46, 01 Jul. 2022
南江堂, Japanese - Image findings of malignant lymphoma of the gallbladder
Kuwatani Masaki; Takishin Yunosuke; Mitsuhashi Tomoko; Sakamoto Naoya, Tando, 36, 1, 82, 90, 31 Mar. 2022
Japan Biliary Association, Japanese - IgG4関連疾患に随伴する胆嚢病変の臨床的検討
滝新悠之介; 桑谷将城; 坂本直哉, 日本消化器病学会雑誌(Web), 119, 2022 - Evaluation of the role of shear wave elastography and dispersion slope in patients with pancreatic cancer
滝新悠之介; 桑谷将城; 西田睦; 三橋智子; 岸法磨; 永井孝輔; 古川龍太郎; 平田甫; 川久保和道; 坂本直哉, 超音波医学 Supplement, 49, 2022 - Image findings of malignant lymphoma of the gallbladder
桑谷将城; 瀧新悠之介; 三橋智子; 坂本直哉, 胆道(Web), 36, 1, 2022 - 膵癌に対するrBC2LCN-IR700複合体を利用した近赤外線光免疫治療の基礎的検討
平田甫; 桑谷将城; 坂本直哉, 日本消化器病学会雑誌(Web), 119, 2022 - 選択的胆管アプローチ困難例に対するmulti-lumen catheterの有用性
永井孝輔; 桑谷将城; 坂本直哉; 岸法磨; 平田甫; 滝新悠之介; 古川龍太郎; 川久保和道, Gastroenterological Endoscopy (Web), 64, Supplement1, 2022 - 複数のtrouble shootingによって内視鏡的治療に成功した膵石の1例
加藤茜; 桑谷将城; 岸法磨; 永井孝輔; 瀧新悠之介; 平田甫; 古川龍太郎; 川久保和道; 坂本直哉, 日本消化器病学会北海道支部例会・日本消化器内視鏡学会北海道支部例会プログラム・抄録集, 130th-124th, 2022 - 切除不能進行・再発胆道がんに対するがん遺伝子関連検査と個別化医療の現状
川本泰之; 川本泰之; 原田一顕; 山村貴洋; 山村貴洋; 斎藤里佳; 斎藤里佳; 伊藤憲; 伊藤憲; 結城敏志; 桑谷将城; 小松嘉人; 小松嘉人; 坂本直哉, 日本消化器病学会北海道支部例会・日本消化器内視鏡学会北海道支部例会プログラム・抄録集, 130th-124th, 2022 - ERCP後膵炎の発症におけるIL-6アンプ関連遺伝子の解析
古川龍太郎; 古川龍太郎; 桑谷将城; 岸法磨; 永井孝輔; 平田甫; 瀧新悠之介; 川久保和道; 村上正晃; 平野聡; 坂本直哉, 日本消化器病学会北海道支部例会・日本消化器内視鏡学会北海道支部例会プログラム・抄録集, 130th-124th, 2022 - 標的胆管分枝アプローチ困難例に対するmulti-lumen catheterの有用性
永井孝輔; 桑谷将城; 岸法磨; 滝新悠之介; 古川龍太郎; 平田甫; 川久保和道; 坂本直哉, 日本消化器病学会北海道支部例会・日本消化器内視鏡学会北海道支部例会プログラム・抄録集, 130th-124th, 2022 - 高齢者・非高齢者に転移を有する膵癌患者の臨床的背景と薬物療法治療成績に関する単施設後方視的検討
川本泰之; 川本泰之; 渡辺亮介; 中村赳晶; 中村赳晶; 山村貴洋; 山村貴洋; 原田一顕; 結城敏志; 桑谷将城; 小松嘉人; 坂本直哉, 日本高齢消化器病学会誌, 25, 1, 2022 - 膵空腸吻合部狭窄に対する治療:バルーン内視鏡下治療から超音波内視鏡下治療への順次的移行戦略
岸法磨; 桑谷将城; 永井孝輔; 滝新悠之介; 古川龍太郎; 平田甫; 川久保和道; 坂本直哉, Gastroenterological Endoscopy (Web), 64, Supplement1, 2022 - 術後再建腸管例に対する受動湾曲機能付大腸内視鏡を用いた胆道および胆管結石処置の有用性
加藤新; 甲谷理紗子; 村井太一; 板谷一史; 小池祐太; 出水孝章; 遠藤文菜; 小野雄司; 中村路夫; 西川秀司; 桑谷将城, Gastroenterological Endoscopy (Web), 64, Supplement2, 2022 - 転移を有する高齢・非高齢膵がん患者の臨床的背景と薬物療法治療成績の後方視的検討
川本泰之; 川本泰之; 渡辺亮介; 中村赳晶; 中村赳晶; 山村貴洋; 山村貴洋; 原田一顕; 結城敏志; 桑谷将城; 桑谷将城; 小松嘉人; 坂本直哉, 日本癌治療学会学術集会(Web), 60th, 2022 - 悪性肝門部胆管閉塞に対する術前内視鏡的胆道ドレナージの機能不全リスクの検討
杉浦諒; 桑谷将城; 坂本直哉, 胆道(Web), 36, 3, 2022 - 膵癌術前化学療法における適切な胆管ステントの検討
岸法磨; 桑谷将城; 坂本直哉, 胆道(Web), 36, 3, 2022 - 胆管空腸吻合術後の胆管に棒状構造物が迷入した4例
米村洋輝; 桑谷将城; 野澤俊一郎; 岸法磨; 永井孝輔; 杉浦諒; 川久保和道; 坂本直哉, 日本消化器病学会北海道支部例会・日本消化器内視鏡学会北海道支部例会プログラム・抄録集, 131st-125th, 2022 - 胆膵疾患に対する外科切除症例における胆膵バルーン内視鏡治療の現状
杉浦諒; 桑谷将城; 野澤俊一郎; 米村洋輝; 岸法磨; 永井孝輔; 川久保和道; 坂本直哉, 日本消化器病学会北海道支部例会・日本消化器内視鏡学会北海道支部例会プログラム・抄録集, 131st-125th, 2022 - 当初非切除と診断した胆道癌に対するConversion手術症例の検討
野路武寛; 野路武寛; 永山稔; 永山稔; 今井浩二; 今井浩二; 川本泰之; 川本泰之; 桑谷将城; 桑谷将城; 今村将史; 今村将史; 木村康利; 木村康利; 岡村圭祐; 岡村圭祐; 平野聡; 平野聡, 日本消化器病学会北海道支部例会・日本消化器内視鏡学会北海道支部例会プログラム・抄録集, 131st-125th, 2022 - Near-infrared photoimmunotherapy for pancreatic ductal adenocarcinoma using rBC2LC-N Lectin-photosensitizer conjugate.
平田甫; 中島孝平; 小川美香子; 桑谷将城; 坂本直哉, 日本癌学会学術総会抄録集(Web), 81st, 2022 - The Platform for Evaluating Biomarkers of Early Detection of Cancer for supporting real-world evidence
Kashiro Ayumi; Konishi Hiroshi; Nomura Yumiko; Kutsumi Hiromu; Shimada Hideaki; Nakamori Syoji; Tsubouchi Hirohito; Iwashita Yuji; Ido Akio; Tanoue Shiro; Fujita Hiroshi; Sakamoto Naoya; Kuwatani Masaki; Noro Rintaro; Ohtsuki Sumio; Nara Satoshi; Shibahara Takahiko; Takano Masayuki; Kikuchi Shojiro; Kato Shingo; Uzawa Narikazu; Ochiai Hiroki; Tsuchida Akihiko; Obata Daisuke; Oketani Kaoru; Ehara Sakiko; Takeuchi Keiko; Nagashima Kengo; Honda Kazufumi, Japan Journal of Molecular Tumor Marker Research, 37, 49, 50, 2022
Japanese Society for Molecular Tumor Marker Research, Japanese - リアルワールドエビデンスを支援する「バイオマーカー迅速検証プラットフォーム」について
加城 歩; 小西 宏; 野村 由美子; 久津見 弘; 島田 英昭; 中森 正二; 坪内 博仁; 岩下 祐司; 井戸 章雄; 田ノ上 史郎; 藤田 浩; 坂本 直哉; 桑谷 将城; 野呂 林太郎; 大槻 純男; 奈良 聡; 柴原 孝彦; 高野 正行; 菊池 正二郎; 加藤 真吾; 鵜澤 成一; 落合 大樹; 土田 明彦; 小畑 大輔; 桶谷 薫; 江原 亮子; 武内 恵子; 長島 健悟; 本田 一文, 日本分子腫瘍マーカー研究会プログラム・講演抄録, 41回, 86, 87, Sep. 2021
日本分子腫瘍マーカー研究会, Japanese - 術前胆道ドレナージにおけるステント留置 : 適応と臨床成績—Preoperative endoscopic biliary stenting for malignant biliary obstruction : indication and clinical outcomes—特集 消化器ステント術のすべて ; 臓器別各論 ; 胆・膵
桒谷 将城; 永井 孝輔; 平田 甫; 瀧新 悠之介; 古川 龍太郎; 川久保 和道; 坂本 直哉; 平野 聡, 外科 = Surgery : 臨床雑誌, 83, 8, 917, 927, Jul. 2021
南江堂, Japanese - Preoperative endoscopic biliary stenting for malignant biliary obstruction: indication and clinical outcomes
桑谷将城; 永井孝輔; 平田甫; 瀧新悠之介; 古川龍太郎; 川久保和道; 坂本直哉; 平野聡, 外科, 83, 8, 917, 927, 01 Jul. 2021
南江堂 - 当初非切除とした胆道癌に対する集学的治療後の外科切除(Conversion surgery)の成績 : 北海道多施設共同研究—Conversion surgery for initially unresectable biliary malignancies : a multicenter retrospective cohort study
野路 武寛; 永山 稔; 今井 浩二; 川本 泰之; 桒谷 将城; 今村 将史; 岡村 圭佑; 木村 康利; 平野 聡, 北海道外科雑誌 = The Hokkaido journal of surgery / 北海道外科雑誌編集委員会 編, 66, 1, 42, 46, Jun. 2021
北海道外科学会, Japanese - 緊急ERCP施行の適応判断における緊急EUSの有用性
古川龍太郎; 桑谷将城; 坂本直哉; 永井孝輔; 平田甫; 瀧新悠之介; 川久保和道, Gastroenterological Endoscopy (Web), 63, Supplement1, 2021 - 当初非切除と診断した胆道癌に対するConversion surgery症例の検討:多施設共同後ろ向きコホート研究
野路武寛; 永山稔; 今井浩二; 川本泰之; 桑谷将城; 今村将史; 岡村圭祐; 木村康利; 平野聡, 日本外科学会定期学術集会(Web), 121st, 2021 - EUS-CDSにおける拡張手技:通電法と非通電法の比較検討
永井孝輔; 桑谷将城; 滝新悠之介; 古川龍太郎; 平田甫; 川久保和道; 坂本直哉, 日本消化器病学会北海道支部例会・日本消化器内視鏡学会北海道支部例会プログラム・抄録集, 128th-122nd, 2021 - 胆嚢癌に類似したIgG4関連胆道病変の一例
瀧新悠之介; 桑谷将城; 永井孝輔; 古川龍太郎; 平田甫; 川久保和道; 坂本直哉; 三橋智子, 日本消化器病学会北海道支部例会・日本消化器内視鏡学会北海道支部例会プログラム・抄録集, 128th-122nd, 2021 - 特徴的な胆道鏡所見を呈した好酸球性胆管炎の一例
平田甫; 桑谷将城; 永井孝輔; 瀧新悠之介; 古川龍太郎; 川久保和道; 坂本直哉, 日本消化器病学会北海道支部例会・日本消化器内視鏡学会北海道支部例会プログラム・抄録集, 128th-122nd, 2021 - 膵周囲液体貯留に対する経消化管的超音波内視鏡下ドレナージの臨床成績
永井孝輔; 桑谷将城; 坂本直哉, 日本消化器病学会雑誌(Web), 118, 2021 - 初期画像検査陰性の総胆管結石の診断における超音波内視鏡の有用性の検討:多施設共同非ランダム化非盲検探索的臨床試験(UMIN000028558)
羽場真; 桑谷将城; 潟沼朗生, 胆道(Web), 35, 3, 2021 - 膵周囲液体貯留に対する超音波内視鏡下ドレナージの臨床成績
永井孝輔; 桑谷将城; 岸法磨; 滝新悠之介; 古川龍太郎; 平田甫; 川久保和道; 坂本直哉, 日本消化器病学会北海道支部例会・日本消化器内視鏡学会北海道支部例会プログラム・抄録集, 129th-123rd (CD-ROM), 2021 - 診断に苦慮した悪性リンパ腫による胆道狭窄の一剖検例
平田幸司; 中島克磨; 鈴木和治; 宮本秀一; 木下賢治; 安孫子怜史; 畑中一映; 山本義也; 成瀬宏仁; 桑谷将城; 坂本直哉; 岡崎ななせ; 谷川聖; 田中伸哉, 胆道(Web), 35, 3, 2021 - 膵癌術前内視鏡的胆道ドレナージにおける最適な胆管ステントに関する検討
古川龍太郎; 桑谷将城; 岸法麿; 平田甫; 瀧新悠之介; 川久保和道; 坂本直哉, 日本消化器病学会北海道支部例会・日本消化器内視鏡学会北海道支部例会プログラム・抄録集, 129th-123rd (CD-ROM), 2021 - 膵癌術前内視鏡的胆道ドレナージにおける最適な胆管ステントに関する検討
古川龍太郎; 桑谷将城; 永井孝輔; 平田甫; 瀧新悠之介; 川久保和道; 坂本直哉, 膵臓(Web), 36, 3, 2021 - Advanced perihilar cholangiocarcinoma with partial thrombus like lesion
野路武寛; 松井あや; 桑谷将城; 大場光信; 大場光信; 三橋智子; 平野聡, 胆道(Web), 35, 2, 2021 - 切除不能進行・再発胆道癌に対するGEM・CDDP・S-1の逐次投与と同時併用投与の比較検討
川本泰之; 小松嘉人; 山村貴洋; 斎藤里佳; 伊藤憲; 原田一顕; 結城敏志; 桑谷将城; 坂本直哉, 日本癌治療学会学術集会(Web), 59th, 2021 - 再発胆道癌に対する積極的外科切除の成績
野路武寛; 松井あや; 田中公貴; 中西喜嗣; 渡邉祐介; 浅野賢道; 海老原裕磨; 倉島庸; 中村透; 村上壮一; 土川貴裕; 岡村圭佑; 七戸俊明; 川本泰之; 桑谷将城; 平野聡, 日本消化器外科学会雑誌(Web), 54, Supplement2, 2021 - Can the diagnosis of early chronic pancreatitis lead to the diagnosis of definite chronic pancreatitis?
桑谷将城; 川久保和道; 坂本直哉, 月刊消化器・肝臓内科, 9, 1, 99, 103, Jan. 2021
科学評論社, Japanese - NON-NEGLIGIBLE RATE OF NEEDLE TRACT SEEDING AFTER ENDOSCOPIC ULTRASOUND-GUIDED FINE-NEEDLE ASPIRATION FOR PATIENTS UNDERGOING DISTAL PANCREATECTOMY FOR PANCREATIC CANCER
YANE Kei; KUWATANI Masaki; YOSHIDA Makoto; GOTO Takuma; MATSUMOTO Ryusuke; IHARA Hideyuki; OKUDA Toshinori; TAYA Yoko; EHIRA Nobuyuki; KUDO Taiki; ADACHI Takeya; ETO Kazunori; ONODERA Manabu; SANO Itsuki; NOJIMA Masanori; KATANUMA Akio, GASTROENTEROLOGICAL ENDOSCOPY, 63, 1, 104, 116, 2021
Background and aims: Needle tract seeding after preoperative endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) for pancreatic body and tail cancer has been reported. This study aimed to investigate the long-term outcomes, including the needle tract seeding ratio, of patients undergoing distal pancreatectomy for pancreatic body and tail cancer diagnosed preoperatively by EUS-FNA.
Methods: This retrospective, observational cohort study assessed patients from three university hospitals and 11 tertiary referral centers. All patients who underwent distal pancreatectomy for invasive cancer of the pancreatic body and tail between January 2006 and December 2015 were identified and reviewed. Needle tract seeding rate, recurrence-free survival (RFS), and overall survival (OS) were evaluated.
Results: Of the 301 total patients analyzed, 176 underwent preoperative EUS-FNA (EUS-FNA group) and 125 did not (non- EUS-FNA group). The median follow-up periods of the EUS-FNA group and non-EUS-FNA group were 32.8 and 30.1 months. Six patients (3.4%) in the EUS-FNA group were diagnosed as having needle tract seeding. The 5-year cumulative needle tract seeding rate estimated using Fine and Gray’s method was 3.8% (95% CI 1.6-7.8%). The median RFS or OS was not significantly different between the EUS-FNA group and the non-EUS-FNA group (23.7 vs 16.9 months: P=0.205; 48.0 vs 43.9 months: P=0.392).
Conclusion: Although preoperative EUS-FNA for pancreatic body and tail cancer has no negative effect on RFS or OS, needle tract seeding after EUS-FNA was observed to have a non-negligible rate. (UMIN000030719), Japan Gastroenterological Endoscopy Society, Japanese - Causes and Treatment of Iatrogenic Biliary Infection
桑谷将城; 桑谷将城; 永井孝輔; 平田甫; 瀧新悠之介; 古川龍太郎; 川久保和道; 坂本直哉, 臨床消化器内科, 36, 9, 1215, 1221, 2021
日本メディカルセンター - Endoscopic transpapillary drainage for benign distal biliary stricture
桑谷将城; 永井孝輔; 平田甫; 瀧新悠之介; 古川龍太郎; 川久保和道; 坂本直哉, 消化器内視鏡, 33, 3, 2021 - Risk and Treatment of Postoperative Biliary Stricture After Resection of Gallbladder Cancer
桑谷将城; 桑谷将城; 永井孝輔; 平田甫; 瀧新悠之介; 古川龍太郎; 川久保和道; 坂本直哉, 胆と膵, 42, 7, 2021 - Pseudolithiasis in the gallbladder
桑谷将城, 日本臨床, 2021 - FEASIBILITY OF DIGITAL PCR-BASED QUANTIFICATION AND MUTATION ANALYSIS OF PLASMA CELL-FREE DNA FOR DIAGNOSIS AND SURVEILLANCE OF EARLY-STAGE PANCREATIC TUMORS
Tetsuhiro Okada; Yusuke Mizukami; Kazuya Koizumi; Kuniyuki Takahashi; Hirotoshi Iwano; Shingo Asahara; Masaki Kuwatani; Toru Kawamoto; Hiroki Sato; Akihiro Hayashi; Hidemasa Kawabata; Takuma Goto; Junpei Sasajima; Mikihiro Fujiya; Yusuke Ono; Hidenori Karasaki; Toshikatsu Okumura, GASTROENTEROLOGY, 158, 6, S863, S863, May 2020
English, Summary international conference - Evolution and a promising role of EUS-FNA in gene and future analyses
Masaki Kuwatani; Masaki Kuwatani; Naoya Sakamoto, Endoscopic Ultrasound, 9, 3, 151, 153, May 2020
Report scientific journal - 乳頭膨張型胆管癌と術前診断された胆管上皮内癌の一例
古川龍太郎; 桑谷将城; 三橋智子; 平田甫; 瀧新悠之介; 平田幸司; 加藤新; 平野聡; 坂本直哉, 胆道(Web), 34, 3, 2020 - 肝門部胆管金属ステント留置困難症例におけるES dilatorの有用性
滝新悠之介; 桑谷将城; 坂本直哉; 古川龍太郎; 平田甫; 平田幸司; 加藤新, 胆道(Web), 34, 3, 2020 - 血漿遊離核酸を用いた膵腫瘍診断
岡田 哲弘; 水上 裕輔; 河本 徹; 林 明宏; 佐藤 裕基; 河端 秀賢; 後藤 拓磨; 笹島 順平; 小泉 一也; 高橋 邦幸; 岩野 博俊; 浅原 新吾; 桑谷 将城; 唐崎 秀則; 奥村 利勝, 膵臓, 34, 3, A106, A107, Jun. 2019
日本膵臓学会, Japanese - 十二指腸 傍十二指腸ヘルニア
桑谷将城; 坂本直哉, 日本臨床, 2019 - 膵頭部癌に対する術前内視鏡的胆管ステント留置術の臨床成績
平田甫; 桑谷将城; 中島正人; 平田幸司; 杉浦諒; 加藤新; 坂本直哉; 浅野賢道; 平野聡, 胆道(Web), 33, 3, 2019 - 遠位良性胆道狭窄に対する経乳頭的金属ステント留置の効果
加藤新; 桑谷将城; 平田甫; 滝新悠之介; 平田幸司; 古川龍太郎; 坂本直哉, 胆道(Web), 33, 3, 2019 - 悪性肝門部胆管閉塞症例の術前内視鏡的経鼻胆管ドレナージチューブ閉塞の危険因子解析
杉浦諒; 桑谷将城; 平田甫; 中島正人; 平田幸司; 加藤新; 坂本直哉, 胆道(Web), 33, 3, 2019 - 血漿遊離核酸を用いた膵腫瘍診断
岡田哲弘; 岡田哲弘; 水上裕輔; 水上裕輔; 河本徹; 林明宏; 佐藤裕基; 河端秀賢; 後藤拓磨; 笹島順平; 小泉一也; 高橋邦幸; 岩野博俊; 浅原新吾; 桑谷将城; 唐崎秀則; 奥村利勝, 膵臓(Web), 34, 3, 2019 - 【Biliary access大辞典】EUSガイド下biliary access EUS-RVテクニック
川久保 和道; 桑谷 将城; 杉浦 諒; 加藤 新; 平田 幸司; 平田 甫; 中島 正人; 坂本 直哉, 胆と膵, 39, 臨増特大, 1117, 1121, Nov. 2018
医学図書出版(株), Japanese - 超音波内視鏡下穿刺吸引検体により診断可能であった後腹膜胚細胞腫瘍の一例
出口 貴祥; 丸川 活司; 高桑 恵美; 安孫子 光春; 清水 知浩; 恩田 千景; 宮越 里絵; 渡部 涼子; 岡田 宏美; 中 智昭; 加藤 新; 桑谷 将城; 三橋 智子; 松野 吉宏, 北海道臨床細胞学会会報, 27, 21, 26, Nov. 2018
北海道臨床細胞学会, Japanese - 【あれから5年 抗血栓薬-とめない覚悟と勇気】抗血栓薬服用者におけるEUS-FNAおよびinterventional EUSの留意点
川久保 和道; 桑谷 将城; 杉浦 諒; 加藤 新; 平田 幸司; 坂本 直哉, 消化器内視鏡, 30, 10, 1474, 1479, Oct. 2018
(株)東京医学社, Japanese - 超音波検査を用いた肝予備能評価の検討
杉浦 諒; 桑谷 将城; 西田 睦; 平田 幸司; 加藤 新; 川久保 和道; 坂本 直哉, 超音波医学, 45, Suppl., S688, S688, Apr. 2018
(公社)日本超音波医学会, Japanese - 胆管ステントの現況と将来 悪性胆道狭窄に対するメタリックステント留置時の乳頭括約筋切開術付加は、ERCP後膵炎の発症を抑制するか
加藤 新; 桑谷 将城; 坂本 直哉, Gastroenterological Endoscopy, 60, Suppl.1, 612, 612, Apr. 2018
(一社)日本消化器内視鏡学会, Japanese - 超音波内視鏡ガイド下治療の現状と問題点 膵周囲液体貯留に対する超音波内視鏡下ドレナージの現状と問題点
加藤 新; 桑谷 将城; 坂本 直哉, 日本消化器病学会雑誌, 115, 臨増総会, A69, A69, Apr. 2018
(一財)日本消化器病学会, Japanese - 肝門部領域胆管癌の胆管水平方向進展診断における経乳頭的鉗子生検の診断能
杉浦 諒; 桑谷 将城; 平田 幸司; 加藤 新; 川久保 和道; 坂本 直哉, 日本消化器病学会雑誌, 115, 臨増総会, A301, A301, Apr. 2018
(一財)日本消化器病学会, Japanese - 胆膵疾患内視鏡アトラス III.胆嚢 2.腫瘤 進行癌-典型例,壁肥厚型,胆嚢管癌-
桑谷将城; 三橋智子; 坂本直哉, 消化器内視鏡, 30, 2018 - 「症例に学ぶ実践的胆膵超音波検査」
桑谷将城, 超音波検査技術, 43, 6, 2018 - 【膵疾患に対する内視鏡治療の新展開】 膵切除後膵液瘻に対する内視鏡治療
桑谷 将城; 川久保 和道; 加藤 新; 杉浦 諒; 平田 幸司; 平野 聡; 坂本 直哉, 消化器・肝臓内科, 2, 6, 625, 631, Dec. 2017
(有)科学評論社, Japanese - Gastrointestinal: Transurethral endoscopic retrograde pancreatography
K. Kawakubo; M. Kuwatani; T. Shimamura; K. Yamashita; R. Goto; M. Watanabe; Y. Koshizuka; N. Kawamura; D. Iwami; K. Hotta; I. Sano; R. Sugiura; S. Kato; N. Shinohara; A. Taketomi; N. Sakamoto, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 32, 11, 1791, 1791, Nov. 2017
English, Others - 【急性胆嚢炎に対する最新のマネージメント】 胆嚢癌合併例のマネージメント
中西 喜嗣; 岡村 圭祐; 土川 貴裕; 中村 透; 村上 壮一; 倉島 庸; 海老原 裕磨; 野路 武寛; 浅野 賢道; 田中 公貴; 七戸 俊明; 平野 聡; 桑谷 将城; 平田 幸司, 胆と膵, 38, 10, 1233, 1236, Oct. 2017
医学図書出版(株), Japanese - 【Interventional EUSの最新情報-適応、手技、デバイス-】 胆管挿管困難例に対するEUS-guided rendezvous technique
川久保 和道; 桑谷 将城; 加藤 新; 杉浦 諒; 平田 幸司; 坂本 直哉, 消化器・肝臓内科, 2, 3, 274, 281, Sep. 2017
(有)科学評論社, Japanese - 北海道多施設共同研究における膵癌術前化学(放射線)療法中の胆道ドレナージの臨床成績 metal stent vs.plastic stent
桑谷 将城; 中村 透; 林 毅; 木村 康利; 小野 道洋; 本谷 雅代; 山北 圭介; 後藤 拓磨; 高橋 邦幸; 真口 宏介; 平野 聡; 坂本 直哉, 胆道, 31, 3, 567, 567, Aug. 2017
日本胆道学会, Japanese - 先天性胆道拡張症に併発した多発胆道癌に対し,生体肝移植と膵頭十二指腸切除を同時実施した1例
腰塚靖之; 川村典生; 渡辺正明; 後藤了一; 川久保和道; 桑谷将城; 山下健一郎; 蒲池浩文; 神山俊哉; 武冨紹信; 嶋村剛, 日本移植学会総会プログラム抄録集, 53rd, 総会臨時, 378, 378, Aug. 2017
(一社)日本移植学会, Japanese - A retrospective cohort study of the relations between progress of chemotherapy and outcomes for metastatic pancreatic cancer
Kawamoto Yasuyuki; Yuki Satoshi; Yagisawa Masataka; Muranaka Tetsuhito; Harada Kazuaki; Nakatsumi Hiroshi; Kawakubo Kazumichi; Kuwatani Masaki; Sakamoto Naoya; Komatsu Yoshito, ANNALS OF ONCOLOGY, 28, Jun. 2017
English, Summary international conference - The Efficacy and Safety of a Novel Transpapillary Dilation Technique With a Diathermic Catheter for Severe Malignant Bile Duct Stricture
Shin Kato; Masaki Kuwatani; Ryo Sugiura; Itsuki Sano; Kazumichi Kawakubo; Naoya Sakamoto, GASTROINTESTINAL ENDOSCOPY, 85, 5, AB631, AB632, May 2017
English, Summary international conference - Mid- to Long-Term Outcomes After Therapeutic Ercp Using Balloon-Assisted Enteroscopy for Anastomotic Stenosis of Choledochojejunostomy or Pancreaticojejunostomy: A Multicenter Observation Study in Japan
Itsuki Sano; Akio Katanuma; Masaki Kuwatani; Hiroshi Kawakami; Hironari Kato; Takao Itoi; Michihiro Ono; Atsushi Irisawa; Yoshinobu Okabe; Takuji Iwashita; Ichiro Yasuda; Shomei Ryozawa; Seiji Kaino; Naoya Sakamoto, GASTROINTESTINAL ENDOSCOPY, 85, 5, AB228, AB229, May 2017
English, Summary international conference - Endoscopic Reintervention Following Multiple Metallic Stent Placement for Hilar Malignant Biliary Stricture
Kazumichi Kawakubo; Masaki Kuwatani; Itsuki Sano; Ryo Sugiura; Shin Kato; Naoya Sakamoto, GASTROINTESTINAL ENDOSCOPY, 85, 5, AB617, AB617, May 2017
English, Summary international conference - 北海道内多施設共同研究における切除不能・局所進行膵癌の治療成績
木村 康利; 中村 透; 林 毅; 桑谷 将城; 本谷 雅代; 小野 道洋; 山北 圭介; 後藤 拓磨; 高橋 邦幸; 真口 宏介; 平野 聡; 竹政 伊知朗; 北海道膵癌研究グループ; Hokkaido; Pancreatic Cancer; Study Group; HOPS, 膵臓, 32, 3, 537, 537, May 2017
日本膵臓学会, Japanese - 【今IPMNをどう診るか】 サーベイランスをめぐる諸問題 IPMNの予後を決める因子は?
川久保 和道; 多田 稔; 桑谷 将城; 佐野 逸紀; 杉浦 諒; 加藤 新; 坂本 直哉, 肝・胆・膵, 74, 4, 597, 600, Apr. 2017
(株)アークメディア, Japanese - 膵周囲液体貯留に対する経消化管的超音波内視鏡下ドレナージの臨床成績
加藤新; 桑谷将城; 坂本直哉, Gastroenterological Endoscopy (Web), 59, Supplement2, 2017 - Hepatobiliary and Pancreatic: A rare case of a well-differentiated neuroendocrine tumor in the bile duct with spontaneous regression diagnosed by EUS-FNA
I. Sano; M. Kuwatani; R. Sugiura; S. Kato; K. Kawakubo; T. Ueno; Y. Nakanishi; T. Mitsuhashi; H. Hirata; S. Haba; S. Hirano; N. Sakamoto, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 32, 1, 11, 11, Jan. 2017
English, Others - 切除不能膵癌に対する化学療法の進歩と治療成績の関係の検討(単施設の後方視的検討)
川本泰之; 川本泰之; 結城敏志; 八木澤允貴; 八木澤允貴; 村中徹人; 村中徹人; 原田一顕; 原田一顕; 中積宏之; 中積宏之; 川久保和道; 桑谷将城; 小松嘉人; 坂本直哉, 日本臨床腫瘍学会学術集会(CD-ROM), 15th, ROMBUNNO.P1‐107, 2017
Japanese - A case of bile duct neuroendocrine tumor preoperatively diagnosed by endoscopic ultrasonography-guided fine-needle aspiration biopsy
Shin Kato; Masaki Kuwatani; Ryo Sugiura; Itsuki Sano; Kazumichi Kawakubo; Naoya Sakamoto; Yoshitsugu Nakanishi; Satoshi Hirano; Takashi Ueno; Tomoko Mitsuhashi, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 31, 231, 231, Nov. 2016
English, Summary international conference - Erratum: Liver elasticity measurement before and after biliary drainage in patients with obstructive jaundice: A prospective cohort study [BMC Gastroenterol. 16 (2016) (65)] DOI: 10.1186/s12876-016-0479-3
Kimitoshi Kubo; Hiroshi Kawakami; Hiroshi Kawakami; Masaki Kuwatani; Mutsumi Nishida; Kazumichi Kawakubo; Shuhei Kawahata; Yoko Taya; Yoshimasa Kubota; Yoshimasa Kubota; Toraji Amano; Hiroki Shirato; Naoya Sakamoto, BMC Gastroenterology, 16, 1, 116, 116, 20 Sep. 2016, [International Magazine]
English - Asian consensus statements on endoscopic management of walled-off necrosis. Part 2: Endoscopic management.
Hiroyuki Isayama; Yousuke Nakai; Rungsun Rerknimitr; Christopher Khor; James Lau; Hsiu-Po Wang; Dong Wan Seo; Thawee Ratanachu-Ek; Sundeep Lakhtakia; Tiing Leong Ang; Shomei Ryozawa; Tsuyoshi Hayashi; Hiroshi Kawakami; Natusyo Yamamoto; Takuji Iwashita; Fumihide Itokawa; Masaki Kuwatani; Masayuki Kitano; Keiji Hanada; Hirofumi Kogure; Tsuyoshi Hamada; Ryan Ponnudurai; Jong Ho Moon; Takao Itoi; Ichiro Yasuda; Atsushi Irisawa; Iruru Maetani, Journal of gastroenterology and hepatology, 31, 9, 1555, 65, Sep. 2016, [International Magazine]
Walled-off necrosis (WON) is a new term for encapsulated necrotic tissue after severe acute pancreatitis. Various terminologies such as pseudocyst, necroma, pancreatic abscess, and infected necrosis were previously used in the literature, resulting in confusion. The current and past terminologies must be reconciled to meaningfully interpret past data. Recently, endoscopic necrosectomy was introduced as a treatment option and is now preferred over surgical necrosectomy when the expertise is available. However, high-quality evidence is still lacking, and there is no standard management strategy for WON. The consensus meeting aimed to clarify the diagnostic criteria for WON and the role of endoscopic interventions in its management. In the Consensus Conference, 27 experts from eight Asian countries took an active role and examined key clinical aspects of WON diagnosis and endoscopic management. Statements were crafted based on literature review and expert opinion, employing the modified Delphi method. All statements were substantiated by the level of evidence and the strength of the recommendation. We created 27 consensus statements for WON diagnosis and management, including details of endoscopic procedures. When there was not enough solid evidence to support the statements, this was clearly acknowledged to facilitate future research. Proposed management strategies were formulated and are illustrated using flow charts. These recommendations, which are based on the best current scientific evidence and expert opinion, will be useful for guiding endoscopic management of WON. Part 2 of this statement focused on the endoscopic management of WON., English, Meeting report - Asian consensus statements on endoscopic management of walled-off necrosis Part 1: Epidemiology, diagnosis, and treatment.
Hiroyuki Isayama; Yousuke Nakai; Rungsun Rerknimitr; Christopher Khor; James Lau; Hsiu-Po Wang; Dong Wan Seo; Thawee Ratanachu-Ek; Sundeep Lakhtakia; Tiing Leong Ang; Shomei Ryozawa; Tsuyoshi Hayashi; Hiroshi Kawakami; Natusyo Yamamoto; Takuji Iwashita; Fumihide Itokawa; Masaki Kuwatani; Masayuki Kitano; Keiji Hanada; Hirofumi Kogure; Tsuyoshi Hamada; Ryan Ponnudurai; Jong Ho Moon; Takao Itoi; Ichiro Yasuda; Atsushi Irisawa; Iruru Maetani, Journal of gastroenterology and hepatology, 31, 9, 1546, 54, Sep. 2016, [International Magazine]
Walled-off necrosis (WON) is a relatively new term for encapsulated necrotic tissue after severe acute pancreatitis. Various terminologies such as pseudocyst, necroma, pancreatic abscess, and infected necrosis were previously used in the literature, resulting in confusion. The current and past terminologies must be reconciled to meaningfully interpret past data. Recently, endoscopic necrosectomy was introduced as a treatment option and is now preferred over surgical necrosectomy when the expertise is available. However, high-quality evidence is still lacking, and there is no standard management strategy for WON. The consensus meeting aimed to clarify the diagnostic criteria for WON and the role of endoscopic interventions in its management. In the Consensus Conference, 27 experts from eight Asian countries took an active role and examined key clinical aspects of WON diagnosis and endoscopic management. Statements were crafted based on literature review and expert opinion, employing the modified Delphi method. All statements were substantiated by the level of evidence and the strength of the recommendation. We created 27 consensus statements for WON diagnosis and management, including details of endoscopic procedures. When there was not enough solid evidence to support the statements, this was clearly acknowledged to facilitate future research. Proposed management strategies were formulated and are illustrated using flow charts. These recommendations, which are based on the best current scientific evidence and expert opinion, will be useful for guiding endoscopic management of WON. Part 1 of this statement focused on the epidemiology, diagnosis, and timing of intervention., English, Meeting report - Liver elasticity measurement before and after biliary drainage in patients with obstructive jaundice: A prospective cohort studya prospective cohort study
Kimitoshi Kubo; Hiroshi Kawakami; Hiroshi Kawakami; Masaki Kuwatani; Mutsumi Nishida; Kazumichi Kawakubo; Shuhei Kawahata; Yoko Taya; Yoshimasa Kubota; Yoshimasa Kubota; Toraji Amano; Hiroki Shirato; Naoya Sakamoto, BMC Gastroenterology, 16, 1, 08 Jul. 2016
Springer Science and Business Media LLC - Pancreatic Cancer With Infectious Pancreatic Pseudocyst Communicating to the Portal Vein
Kimitoshi Kubo; Hiroshi Kawakami; Masaki Kuwatani; Tomoko Mitsuhashi; Kazumichi Kawakubo; Shuhei Kawahata; Yoshimasa Kubota; Naoya Sakamoto, PANCREAS, 45, 6, 925, 926, Jul. 2016
English, Summary international conference - Advantage and Disadvantage of Endoscopic Ultrasonography-Guided Fistula Creation As a Biliary Drainage Method
Masaki Kuwatani; Hiroshi Kawakami; Kazumichi Kawakubo; Shuhei Kawahata; Kimitoshi Kubo; Yoshimasa Kubota; Naoya Sakamoto, GASTROINTESTINAL ENDOSCOPY, 83, 5, AB355, AB355, May 2016
English, Summary international conference - Risk of Bleeding After Endoscopic Ultrasnography-Guided Fine Needle Aspiration for Patients With Antithrombotic Agents; a Prospective Multicenter Study
Kazumichi Kawakubo; Kei Yane; Kazunori Eto; Hirotoshi Ishiwatari; Nobuyuki Ehira; Shin Haba; Ryusuke Matsumoto; Keisuke Shinada; Hiroaki Yamato; Taiki Kudo; Manabu Onodera; Toshinori Okuda; Yoko Taya; Shuhei Kawahata; Kimitoshi Kubo; Yoshimasa Kubota; Masaki Kuwatani; Hiroshi Kawakami; Akio Katanuma; Michihiro Ono; Tsuyoshi Hayashi; Minoru Uebayashi; Naoya Sakamoto, GASTROINTESTINAL ENDOSCOPY, 83, 5, AB208, AB208, May 2016
English, Summary international conference - 新たに定義された“肝門部領域胆管癌”の診断と治療 治療方針決定のための診断法-POCSによる診断-
河上洋; 久保田良政; 桑谷将城; 川久保和道; 川畑修平; 久保公利; 坂本直哉, 胆と膵, 37, 1, 2016 - 卵膜由来間葉系幹細胞を用いた急性および慢性膵炎に対する新規治療法
川久保和道; 大西俊介; 桑谷将城; 大西礼造; 坂本直哉, 再生医療, 15, 2016 - Interventional EUSのすべて EUSガイド下膵管ドレナージ術
河上洋; 久保田良政; 桑谷将城; 川久保和道, 消化器内視鏡, 28, 10, 2016 - 胆膵内視鏡自由自在~基本手技を学び応用力をつける集中講座~ERCP関連手技編:乳頭処置 内視鏡的乳頭大径バルーン拡張術(EPLBD)の適応と偶発症予防
川畑修平; 桑谷将城; 川久保和道; 坂本直哉, 胆と膵, 37, 2016 - 生涯教育シリーズ XXI 消化器疾患診療の最前線 16.胆膵疾患に対する内視鏡診断・治療の最前線
桑谷将城; 桑谷将城; 河上洋; 坂本直哉, 北海道医報, 1172, 2016 - A case with a fibrous polyp of the gallbladder with a formal change that was observed for seven years
Kubo Kimitoshi; Kawakami Hiroshi; Kubota Yoshimasa; Kawahata Shuhei; Kawakubo Kazumichi; Kuwatani Masaki; Ueno Takashi; Mitsuhashi Tomoko; Sakamoto Naoya, Tando, 30, 4, 723, 730, 2016
A 60-year-old male with a tumor of the gallbladder that was detected by screening ultrasonography (US) was referred to our hospital for workup. US revealed a pedunculated polyp at the fundus of gallbladder and diffuse thickened wall of the gallbladder. We followed it on the diagnosis of cholesterol polyp and cholesterosis. During the follow-up period, the polyp tended to enlarge and change morphologically. Since adenoma or gallbladder carcinoma in situ could be considered as a diagnosis of the polyp based on various images, a laparoscopic cholecystectomy was carried out. Resected specimen revealed a light yellowish pedunculated polyp at the fundus of gallbladder and cholesterosis. Histologically, it was covered with a simple epithelium with low-grade atypia and was composed of mucinous edematous stroma with few infiltration of foamy cells in lamina propria, and finally diagnosed as a fibrous polyp. This is a rare case with a fibrous polyp of the gallbladder and has been suspected to change from a cholesterol polyp., Japan Biliary Association, Japanese - Endoscopic nasobiliary drainage has lower incidence of complications than endoscopic biliary stenting for the management of hilar cholangiocarcinoma
Kazumichi Kawakubo; Hiroshi Kawakami; Masaki Kuwatani; Shin Haba; Taiki Kudo; Yoko Abe; Shuhei Kawahata; Yoshimasa Kubota; Kimitoshi Kubo; Kazunori Eto; Nobuyuki Ehira; Hiroaki Yamato; Naoya Sakamoto, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 30, 235, 235, Dec. 2015
English, Summary international conference - 【難治な胆道良性疾患の対処法を考える】 良性胆道疾患別の診断と治療(各論) 虚血性胆管炎
Zen Yoh; 河上洋; 桑谷将城; 三橋智子; 坂本直哉, 肝・胆・膵, 71, 3号, 481, 487, Sep. 2015, [Invited]
Japanese, Introduction commerce magazine - A Prospective Multicenter Study of EUS-Guided Choledochoduodenostomy Using a Covered Metallic Stent As a Primary Biliary Drainage in Unresectable Malignant Biliary Obstruction
Yousuke Nakai; Hiroyuki Isayama; Hiroshi Kawakami; Hirotoshi Ishiwatari; Masayuki Kitano; Yukiko Ito; Ichiro Yasuda; Hironari Kato; Saburo Matsubara; Atsushi Irisawa; Takao Itoi; Masaki Kuwatani; Michihiro Ono; Hajime Imai; Takuji Iwashita; Goro Shibukawa; Takayoshi Tsuchiya, GASTROINTESTINAL ENDOSCOPY, 81, 5, AB423, AB423, May 2015
English, Summary international conference - Mutational Analysis of Pancreatic Neuroendocrine Tumor Using Endoscopic Ultrasound-Guided Fine-Needle Aspiration and Next-Generation Deep Sequencing
Yoshimasa Kubota; Hiroshi Kawakami; Mitsuteru Natsuizaka; Masaki Kuwatani; Kazumichi Kawakubo; Yoko Abe; Shuhei Kawahata; Kimitoshi Kubo; Naoya Sakamoto, GASTROENTEROLOGY, 148, 4, S941, S941, Apr. 2015
English, Summary international conference - Merits and Demerits of Steroid Therapy for IgG4-Related Sclerosing Cholangitis
Masaki Kuwatani; Hiroshi Kawakami; Kazumichi Kawakubo; Shuhei Kawahata; Kimitoshi Kubo; Yoko Abe; Naoya Sakamoto, GASTROENTEROLOGY, 148, 4, S292, S293, Apr. 2015
English, Summary international conference - Hepatobiliary and Pancreatic: A splenic artery aneurysm presenting as a calcified pancreatic mass
K. Kawakubo; H. Kawakami; M. Kuwatani; N. Sakamoto, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 30, 4, 655, 655, Apr. 2015
English, Others - EUS下胆道ドレナージ~EUS-BDの安全な導入へ向けて~Endoscopic ultrasound-guided hepaticogastrostomy(EUS-HGS)の偶発症と対処・予防方法
河上洋; 川久保和道; 桑谷将城; 久保田良政; 川畑修平; 久保公利; 坂本直哉, 胆と膵, 36, 8, 2015 - EUS下胆道ドレナージ~EUS-BDの安全な導入へ向けて~EUS-guided rendezvous techniqueの適応と手技の実際
川久保和道; 河上洋; 桑谷将城; 川畑修平; 羽場真; 久保田良政; 久保公利; 坂本直哉, 胆と膵, 36, 8, 2015 - 胆道癌 II.各論 腺癌 胆嚢癌 治療 集学的治療(内視鏡的ステント留置術-胆道,十二指腸)
河上洋; 桑谷将城; 坂本直哉, 日本臨床, 73, 2015 - APPLICATION OF EUS-FNA FOR DIAGNOSIS OF A MEDIASTINAL LESION AND AVAILABILITY OF COMBINED EUS-FNA AND TBLB
KUBO Kimitoshi; ONODERA Manabu; SOGABE Susumu; ODA Hisashi; MIYAGISHIMA Takuto; TAKAHASHI Tatsurou; KUWATANI Masaki, GASTROENTEROLOGICAL ENDOSCOPY, 57, 7, 1467, 1476, 2015
[Background and aim] Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) of mediastinal lesions has been reported as an available method for diagnosis in the last two decades, while transbronchial lung biopsy (TBLB) has been performed for diagnosis of lung cancer. We aimed to investigate the efficacy of EUS-FNA of a mediastinal lesion and the contribution of EUS-FNA to the diagnosis of lung cancer with TBLB. [Method] Between May 2010 and March 2012, we performed EUS-FNA on a total of 102 lesions (mediastinal lesion, 52 ; pancreatic lesion, 40 ; others, 10). Among them, we retrospectively analyzed the results of EUS-FNA of the 52 mediastinal lesions with the results of TBLB. [Results] The diagnostic rate by EUS-FNA in the 52 lesions was 100% (52/52). The final diagnoses were metastasis of lung cancer to a lymph node, 29 ; metastasis of gastrointestinal or prostate cancer to a lymph node, 3 ; sarcoidosis, 4 ; malignant lymphoma, 2 ; and inflammatory or non-specific lymphadenopathy, 14. The acquisition rates of evaluable cells and tissues obtained by EUS-FNA were 100% (52/52) and 98% (51/52), respectively. Among the 29 patients with lung cancer, the diagnostic accuracy of TBLB was 36% (9/25), and that of both EUS-FNA and TBLB was increased to 100%. [Conclusion] EUS-FNA is effective for diagnosis of a mediastinal lesion. Especially for diagnosis of lung cancer, EUS-FNA plays a complementary role to TBLB., Japan Gastroenterological Endoscopy Society, Japanese - Preoperative biliary drainage for cholangiocarcinoma : Which approach or stent should be selected?
河上 洋; 桒谷 将城; 川久保 和道, 臨床外科 = Journal of clinical surgery, 70, 1, 6, 11, Jan. 2015
医学書院, Japanese - 胆道疾患に対するInterventional EUSの現況と展望 (特集 消化器疾患に対する内視鏡的アプローチの最新情報)
川久保 和道; 河上 洋; 桑谷 将城, 映像情報medical, 46, 9, 833, 839,790-792, Sep. 2014
産業開発機構, Japanese - EGFR阻害剤を用いた食道扁平上皮癌幹細胞を標的とした新規治療法の開発(EGFR inhibitors suppress EMT and diminish cancer stem-like cells in esophageal squamous cell carcinoma)
佐藤 史幸; 夏井坂 光輝; 大橋 真也; 賀川 真吾; 桑谷 将城; 河上 洋; 大西 俊介; 小松 嘉人; 加藤 元嗣; 坂本 直哉, 日本癌学会総会記事, 73回, J, 1034, Sep. 2014
日本癌学会, English - CTNNB1 Mutational Analysis of Solid-Pseudopapillary Neoplasms of the Pancreas Using Endoscopic Ultrasound-Guided Fine-Needle Aspiration and Next-Generation Deep Sequencing
Yoshimasa Kubota; Hiroshi Kawakami; Mitsuteru Natsuizaka; Kazumichi Kawakubo; Katsuji Marukawa; Taiki Kudo; Yoko Abe; Kimitoshi Kubo; Masaki Kuwatani; Yutaka Hatanaka; Tomoko Mitsuhashi; Yoshihiro Matsuno; Naoya Sakamoto, GASTROENTEROLOGY, 146, 5, S871, S871, May 2014
English, Summary international conference - Is wire-guided selective bile duct cannulation effective for the selective bile duct cannulation and prevention of post-ERCP pancreatitis?
河上 洋; 桒谷 将城; 川久保 和道, 消化器内科, 58, 4, 535, 542, Apr. 2014
科学評論社, Japanese - 膵がん退治の始まり 切除不能膵癌に対する内視鏡的intervention-現状と本邦よりのevidence-
河上洋; 桑谷将城; 川久保和道; 阿部容子; 川畑修平; 久保公利; 久保田良政; 佐野逸起; 坂本直哉, 肝胆膵, 68, 6, 2014 - 膵がんと胆道がんの実地診療 これからの実地医家のための診断と鑑別診断および術前ドレナージの実際 術前ドレナージの意義と実際 肝門部胆管がんの術前診断・ドレナージ
河上洋; 桑谷将城; 坂本直哉, Medical Practice, 31, 6, 2014 - Rendezvous biliary recanalization combining percutaneous and endoscopic techniques using a diathermic dilator for bile duct obstruction
Hiroshi Kawakami; Daisuke Abo; Kazumichi Kawakubo; Masaki Kuwatani; Yuki Yoshino; Yoshimasa Kubota; Yoko Abe; Shuhei Kawahata; Kimitoshi Kubo; Yusuke Sakuhara; Hiroki Shirato; Naoya Sakamoto, Endoscopy, 46, E460-1, 01 Jan. 2014, [International Magazine]
English - Spontaneous intraductal stent migration after endoscopic ultrasound-guided choledocho-gastrostomy
K. Kawakubo; H. Kawakami; M. Kuwatani; S. Haba; T. Kudo; Y. Abe; N. Sakamoto, ENDOSCOPY, 45, E89, E90, Dec. 2013
English, Others - 食道扁平上皮癌におけるTGF-βおよびNotch1による癌幹細胞維持機構(TGF-β changes a switch of Notch1-mediated signaling to maintain tumor-initiating cells in esophageal SCC(ESCC))
夏井坂 光輝; 大橋 真也; 長沼 誠二; 大西 俊介; 桑谷 将城; 河上 洋; 中馬 誠; 小松 嘉人; 加藤 元嗣; 坂本 直哉, 日本癌学会総会記事, 72回, 137, 137, Oct. 2013
日本癌学会, English - 肝門部胆管癌に対する術前胆道ドレナージ術は何が適切なのか?
河上 洋; 桑谷 将城; 川久保 和道; 羽場 真; 工藤 大樹; 阿部 容子; 川畑 修平; 田中 栄一; 平野 聡; 浅香 正博; 坂本 直哉, 北海道醫學雜誌 = Acta medica Hokkaidonensia, 88, 2, 90, 90, 01 Apr. 2013
Japanese - 組織学的診断を必須とする立場から (誌上ディベート 膵癌の術前診断はどこまで必要か : 組織学的診断は必須か)
羽場 真; 河上 洋; 桒谷 将城, 膵・胆道癌frontier, 3, 1, 14, 17, Mar. 2013
メディカルレビュー社, Japanese - 胆管・膵管拡張をみたら I.胆管拡張をみたら[典型的症例]肝内・肝外胆管拡張を呈する病変
河上洋; 桑谷将城; 坂本直哉, 消化器内視鏡, 25, 2, 2013 - ドレナージ大全 胆道ドレナージ術:悪性肝門部胆道閉塞 悪性肝門部胆管狭窄-切除例に対する術前胆道ドレナージ術
河上洋; 桑谷将城; 川久保和道; 工藤大樹; 阿部容子; 川畑修平; 久保公利; 久保田良政; 坂本直哉, 胆と膵, 34, 2013 - 胆膵内視鏡新潮流 胆道疾患に対する新しい内視鏡手技 ERCP胆管挿管困難例におけるEUSガイド下ランデブー法
河上洋; 羽場真; 川久保和道; 桑谷将城; 工藤大樹; 阿部容子; 川畑修平; 坂本直哉, 肝胆膵, 66, 1, 2013 - A safety and utility of single-session EUS and ERCP for the evaluation of pancreatobiliary diseases
Kazumichi Kawakubo; Hiroshi Kawakami; Masaki Kuwatani; Yoko Abe; Taiki Kudo; Shin Haba; Naoya Sakamoto, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 27, 77, 77, Dec. 2012
English, Summary international conference - 【胆膵ステントの新しい潮流-開発コンセプトとステント選択を学ぶ-】 EUS-guided hepaticogastrostomy(EUS-HGS)におけるcovered metallic stent 専用ステントの開発コンセプト
川久保 和道; 河上 洋; 桑谷 将城; 羽場 真; 工藤 大樹; 阿部 容子; 伊佐山 浩通; 小池 和彦; 坂本 直哉, 胆と膵, 33, 10, 865, 868, Oct. 2012
医学図書出版(株), Japanese - 胆膵ステントの新しい潮流-開発コンセプトとステント選択を学ぶ-悪性中下部胆管閉塞に対するdrug eluting stent
河上洋; 桑谷将城; 川久保和道; 羽場真; 工藤大樹; 阿部容子; 川畑修平; 坂本直哉, 胆と膵, 33, 10, 2012 - 内視鏡“もう一工夫”ERCP 左右肝内胆管への選択的ガイドワイヤー挿入
河上洋; 桑谷将城; 川久保和道; 坂本直哉, 消化器内視鏡, 24, 9, 2012 - 胆膵内視鏡のビデオライブデモ2012 マスターによるテクニックの解説とビデオライブデモ ENBDによる胆管ドレナージ(1本,2本,3本)
河上洋; 桑谷将城; 川久保和道; 羽場真; 工藤大樹; 阿部容子; 川畑修平; 坂本直哉, 胆と膵, 33, 2012 - ERCP後膵炎を減らせ!-膵炎予防への試み-ガイドワイヤーテクニックを用いたカニュレーションによるERCP後膵炎予防
河上洋; 桑谷将城; 江藤和範; 工藤大樹; 阿部容子; 川畑修平; 加藤元嗣; 浅香正博, 胆と膵, 33, 2, 2012 - Resolution of a refractory severe biliary stricture using a diathermic sheath
H. Kawakami; M. Kuwatani; K. Eto; T. Kudo; Y. Abe; S. Kawahata; M. Kato, Endoscopy, 44, 2, E119, E120, 2012
English, Report scientific journal - Reply to the letter by Yucel Ustundag et al. regarding "Endoscopic nasobiliary drainage is most suitable for preoperative management in patients with hilar cholangiocarcinoma"
Hiroshi Kawakami; Masaki Kuwatani; Eiichi Tanaka; Satoshi Hirano, JOURNAL OF GASTROENTEROLOGY, 47, 1, 90, 91, Jan. 2012
English, Report scientific journal - 膵・胆管合流異常 (特集 胆膵疾患診療の最前線--難治疾患のよりよいマネジメントのために) -- (胆膵疾患のマネジメント--胆膵癌を見据えて)
河上 洋; 近藤 哲; 桑谷 将城, 内科, 107, 3, 432, 436, Mar. 2011
南江堂, Japanese - 肝外胆管(胆管,胆嚢管,総胆管)腫瘍 乳頭型肝外胆管癌,乳頭浸潤型肝外胆管癌
桑谷将城; 河上洋; 近藤哲; 浅香正博, 日本臨床, 2011 - 胆管カニュレーションテクニックの現状と進歩-最新の技術と挿管困難例への対処-Wire-guided Cannulation-テクニックの実際と成功のコツ-
河上洋; 桑谷将城; 江藤和範; 羽場真; 工藤大樹; 阿部容子; 川畑修平; 小野寺学; 大和弘明; 江平宣起; 上林実; 加藤元嗣, 胆と膵, 32, 10, 2011 - 肝切除後の胆管閉塞に対し自作穿刺器具を用いて肝外経路作成後に内外瘻化できた1例
阿保大介; 森谷亮; 長谷川悠; 作原祐介; 白土博樹; 寺江聡; 清水匡; 桑谷将城; 河上洋; 田中栄一; 平野聡; 近藤哲, IVR, 25, 4, 557, 557, 01 Oct. 2010
(一社)日本インターベンショナルラジオロジー学会, Japanese - A Malignant Pancreatic Neuro-Endocrine Tumor With Intraductal Growth within the Main Pancreaic Duct and Tumor Thrombus Within the Splenic Vein
Kazunori Eto; Hiroshi Kawakami; Masaki Kuwatani; Shin Haba; Satoshi Hirano; Satoshi Kondo; Kanako Kubota; Yoshihiro Matuno; Atushi Hirayama; Yuuko Gotouda; Masahiro Asaka, PANCREAS, 39, 5, 699, 700, Jul. 2010
English, Summary international conference - Cholangiographic diagnosis of extension of bile duct cancer on the basis of gross patterns
河上 洋; 桑谷 将城; 小野寺 学, Gastroenterology, 50, 2, 175, 179, Feb. 2010
科学評論社, Japanese - 門脈内腫瘍栓を伴った腎細胞癌多発膵転移の1例
江藤和範; 河上洋; 桑谷将城; 小野寺学; 羽場真; 平野聡; 近藤哲; 浅香正博, 肝胆膵画像, 12, 2, 2010 - 胆膵内視鏡ルネサンス〔ここまで進んだ内視鏡診断〕早期胆管癌
河上洋; 桑谷将城; 江藤和範; 江藤和範; 工藤大樹; 江平宣起; 大和弘明; 近藤哲; 浅香正博, 消化器内視鏡, 22, 12, 2010 - Stenting Bible 胆管狭窄に対するStenting Strategy:悪性肝門部胆管狭窄 アプローチルートの選択-内視鏡か経皮か-
河上洋; 桑谷将城; 羽場真; 小野寺学; 江藤和範; 工藤大樹; 江平宣起; 大和弘明; 近藤哲; 浅香正博, 胆と膵, 31, 2010 - 壁在結節高からみたIPMN切除例の検討
桑谷将城; 河上洋; 近藤哲, Gastroenterological Endoscopy, 52, Supplement 1, 2010 - A Wandering Pancreatic Mass
Masaki Kuwatani; Hiroshi Kawakami; Shin Haba; Kazunori Eto; Manabu Onodera; Masahiro Asaka, INTERNAL MEDICINE, 49, 6, 627, 628, 2010
English, Others - Localized Lymphoplasmacytic Sclerosing Cholecystitis in a Patient with Autoimmune Pancreatitis
Hiroshi Kawakami; Kazunori Eto; Masaki Kuwatani; Masahiro Asaka, INTERNAL MEDICINE, 49, 21, 2359, 2360, 2010
English, Others - 胆膵内視鏡のトラブルシューティング-c.胆道鏡 3.胆管壁からの出血・穿孔
河上洋; 桑谷将城; 小野寺学; 羽場真; 近藤哲; 浅香正博, 消化器内視鏡, 21, 12, 2009 - 胆膵治療内視鏡のエキスパートテクニック ERCP関連手技:胆道ドレナージ術 悪性肝門部・上部胆管狭窄に対する両葉胆道ドレナージ(ENBD)
河上洋; 桑谷将城; 江藤和範; 羽場真; 小野寺学; 近藤哲; 浅香正博, 胆と膵, 30, 2009 - A rare complication with extraction of proximally migrated biliary stent by using a basket catheter
Hiroshi Kawakami; Minoru Uebayashi; Kohei Konishi; Masaki Kuwatani; Keisuke Shinada; Hiroaki Yamato; Masahiro Asaka, GASTROINTESTINAL ENDOSCOPY, 67, 7, 1170, 1171, Jun. 2008
English, Others - IgG4関連硬化性胆管炎の検討-画像所見および組織生検を中心に-
河上洋; 桑谷将城; 浅香正博, 日本消化器病学会雑誌, 105, 2008 - 胆道疾患の診断の進め方 画像診断の基本と実際 画像検査をどう使いこなすか-その特徴,使い分け,組み合わせ PTCS/POCS
河上洋; 桑谷将城; 江藤和範; 羽場真; 近藤哲; 浅香正博, 消化器の臨床, 11, 6, 2008 - 超音波内視鏡検査が術前診断に有用であったpancreatic groove carcinomaの3例
桑谷将城; 河上洋; 大和弘明; 品田恵佐; 田中栄一; 平野聡; 近藤哲; 伊藤智雄; 浅香正博, 日本消化器病学会雑誌, 105, 7, 1061, 1069, 2008 - SOLID-VARIANT TYPE OF SEROUS CYSTADENOMA OF THE PANCREAS ; A CASE REPORT AND REVIEW OF LITERATURES
KUWATANI Masaki; KAWAKAMI Hiroshi; ONODERA Manabu; HIRANO Satoshi; KONDO Satoshi; ITOH Tomoo; KOSHIYAMA Tatsumi; KAWAKAMI Ayae; ASAKA Masahiro, Gastroenterol Endosc, 49, 5, 1303, 1309, 2007
Japanese - In response to transplantation 2006; 80 : 1145-1152
Masaki Kuwatani; Yoshinori Ikarashi; Shin Mineishi; Masahiro Asaka; Hiro Wakasugi, TRANSPLANTATION, 81, 9, 1357, 1358, May 2006
English, Report scientific journal - 黄だんを呈したVater乳頭および下部胆管アミロイド沈着症の1例
桑谷将城; 皆内康一郎; 加藤総介; 大原真理子; 常松泉; 片桐雅樹; 成瀬宏仁; 松嶋喬; 下山則彦, 函館医学誌, 25, 1, 2001
- 膵切除後膵液瘻に対する内視鏡治療
桑谷将城, 消化器・肝臓内科
科学評論社, Dec. 2017, [Joint work] - 胆膵疾患に対する内視鏡診断・治療の最前線
桑谷将城, 北海道医報
北海道医師会, May 2016, 8-12, Japanese, [Joint work] - 乳頭型肝外胆管癌、乳頭浸潤型肝外胆管癌
桑谷将城, 別冊肝・胆道系症候群III
日本臨床, Feb. 2011, [Joint work]
- 悪性肝門部胆管閉塞に対する術前内視鏡的胆道ドレナージの機能不全リスクの検討
杉浦諒; 桑谷将城; 坂本直哉
第58回日本胆道学会学術集会, 13 Oct. 2022, Japanese, Public symposium
13 Oct. 2022 - 14 Oct. 2022 - 膵癌に対するrBC2LCN-IR700複合体を利用した近赤外線光免疫治療の基礎的検討
平田 甫; 桑谷 将城; 坂本 直哉
第108回日本消化器病学会総会, 22 Apr. 2022, Japanese, Public symposium
21 Apr. 2022 - 23 Apr. 2022 - 自己免疫性肝胆膵疾患の新展開 IgG4関連疾患に随伴する胆嚢病変の臨床的検討
滝新 悠之介; 桑谷 将城; 坂本 直哉
第108回日本消化器病学会総会, 22 Apr. 2022, Japanese, Public symposium
21 Apr. 2022 - 23 Apr. 2022 - 膵周囲液体貯留に対する経消化管的超音波内視鏡下ドレナージの臨床成績
永井 孝輔; 桑谷 将城; 坂本 直哉
JDDW 2021, 04 Nov. 2021, Japanese, Public symposium
04 Nov. 2021 - 07 Nov. 2021 - 初期画像検査陰性の総胆管結石の診断における超音波内視鏡の有用性の検討 多施設共同非ランダム化非盲検探索的臨床試験
羽場 真; 桑谷 将城; 潟沼 朗生; Hokkaido Interventional EUS; ERCP study group
第57回日本胆道学会学術集会, 08 Oct. 2021, Japanese, Oral presentation
07 Oct. 2021 - 08 Oct. 2021 - リアルワールドエビデンスを支援する「バイオマーカー迅速検証プラットフォーム」について
加城 歩; 小西 宏; 野村 由美子; 久津見 弘; 島田 英昭; 中森 正二; 坪内 博仁; 岩下 祐司; 井戸 章雄; 田ノ上 史郎; 藤田 浩; 坂本 直哉; 桑谷 将城; 野呂 林太郎; 大槻 純男; 奈良 聡; 柴原 孝彦; 高野 正行; 菊池 正二郎; 加藤 真吾; 鵜澤 成一; 落合 大樹; 土田 明彦; 小畑 大輔; 桶谷 薫; 江原 亮子; 武内 恵子; 長島 健悟; 本田 一文
第41回日本分子腫瘍マーカー研究会, 29 Sep. 2021, Japanese, Oral presentation
29 Sep. 2021 - 29 Sep. 2021 - 超音波内視鏡下胆道ドレナージにおける拡張手技 通電法と非通電法の比較検討
永井 孝輔; 桑谷 将城; 坂本 直哉
第101回 日本消化器内視鏡学会総会, 16 May 2021, Japanese, Public symposium
14 May 2021 - 16 May 2021 - IgG4関連硬化性胆管炎におけるステロイド治療後の再燃因子の検討
滝新 悠之介; 桑谷 将城; 坂本 直哉
第107回日本消化器病学会総会, 15 Apr. 2021, Japanese, Public symposium
15 Apr. 2021 - 17 Apr. 2021 - 新規LEDカテーテルを使用した胆管癌に対する光免疫治療効果の検証
平田 甫; 桑谷 将城; 中島 孝平; 小川 美香子; 坂本 直哉
第79回日本癌学会総会, Oct. 2020, Japanese, Oral presentation
01 Oct. 2020 - 03 Oct. 2020 - 超音波内視鏡下穿刺生検検体による胆道癌遺伝子解析
平田 幸司; 桑谷 将城; 坂本 直哉
第105回日本消化器病学会総会, 09 May 2019, Japanese, Public symposium
09 May 2019 - 11 May 2019 - 北海道多施設共同研究における膵癌術前化学(放射線)療法中の胆道ドレナージの臨床成績 metal stent vs.plastic stent
桑谷 将城; 中村 透; 林 毅; 木村 康利; 小野 道洋; 本谷 雅代; 山北 圭介; 後藤 拓磨; 高橋 邦幸; 真口 宏介; 平野 聡; 坂本 直哉
胆道, Aug. 2017, Japanese - 胆管ドレナージにおける超音波内視鏡下胆管十二指腸吻合術の適応と限界
桑谷 将城; 河上 洋; 川久保 和道; 坂本 直哉
Gastroenterological Endoscopy, Oct. 2016, Japanese - 胆道疾患に対する超音波内視鏡の有用性 超音波内視鏡下胆管十二指腸吻合術による胆管ドレナージの適応と限界
桑谷 将城; 河上 洋; 川久保 和道
胆道, Aug. 2016, Japanese - 胆膵におけるInterventional EUS 超音波内視鏡下瘻孔形成術 偶発症とその対策 胆管ドレナージ法としての超音波内視鏡下瘻孔形成術の功罪の検証
桑谷 将城; 河上 洋; 坂本 直哉
Gastroenterological Endoscopy, Apr. 2016, Japanese - 胆膵内視鏡検査・治療のトラブルシューティング 超音波内視鏡ガイド下胆管ドレナージにおけるトラブルとその対処法
桑谷 将城; 河上 洋; 坂本 直哉
Gastroenterological Endoscopy, Sep. 2015, Japanese - 胆道内視鏡診断・治療の進歩(バルーン内視鏡を含めて) 超音波内視鏡ガイド下胆管アプローチおよび処置における偶発症とその対策
桑谷 将城; 河上 洋; 坂本 直哉
胆道, Aug. 2015, Japanese - PSCとIgG4-SC わが国の現状と最適治療を目指して IgG4関連硬化性胆管炎に対するステロイド治療の功罪
桑谷 将城; 河上 洋; 坂本 直哉
日本消化器病学会雑誌, Mar. 2015, Japanese - 胆管結石治療困難例への戦略 内視鏡的胆管結石治療困難例に対する効率的な治療 EUS-guided stone therapy
桑谷 将城; 河上 洋; 川久保 和道
Gastroenterological Endoscopy, Sep. 2014, Japanese - 気遣いの内視鏡 超音波内視鏡検査における鎮痙剤の役割 鎮痙剤の有無に関する多施設共同前向き無作為化比較試験
桑谷 将城; 林 毅; 河上 洋
Gastroenterological Endoscopy, Apr. 2014, Japanese - 膵内分泌腫瘍におけるEUS-FNAの有用性と限界 外科的切除標本との比較検討
桑谷 将城; 河上 洋; 川久保 和道; 羽場 真; 工藤 大樹; 阿部 容子; 坂本 直哉
膵臓, Jun. 2013, Japanese
- 医学総論, 2024年, 博士後期課程, 医学研究科
- 基本医学研究, 2024年, 修士課程, 医学院
- 基本医学総論, 2024年, 修士課程, 医学院
- 医学総論, 2024年, 博士後期課程, 医学院
- 基盤医学研究, 2024年, 博士後期課程, 医学院
- 臨床医学研究, 2024年, 博士後期課程, 医学院
- Effect of adenosine signal pathway on tumor immune evasion in biliary tract cancer
Grants-in-Aid for Scientific Research
01 Apr. 2025 - 31 Mar. 2028
川久保 和道; 杉浦 諒; 桑谷 将城
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 25K11218 - Effect of tumor microbiome on tumor immune evasion in pancreatic cancer
Grants-in-Aid for Scientific Research
01 Apr. 2024 - 31 Mar. 2027
結城 敏志; 川久保 和道; 川本 泰之; 桑谷 将城
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 24K10445 - 外分泌機能推定による膵がん悪性化リスク層別化に有用な血液バイオマーカーの臨床開発
Apr. 2024 - Mar. 2027
本田一文; 加藤真吾; 小林隆; 井戸章雄; 田口宏樹; 藤田浩; 桒谷将城; 長島健悟; 桶谷薫; 安達督; 久津見弘
国立研究開発法人 日本医療研究開発機構（AMED）, Coinvestigator, 24015075 - Development of endoscopic dual photoimmunotherapy targeting pancreatic cancer cells and cancer-associated fibroblasts
Grants-in-Aid for Scientific Research
Apr. 2023 - Mar. 2026
桑谷 将城; 中島孝平; 川久保和道
方法：ヒト膵癌細胞株(Panc04.03，Capan-1，SUIT-2)，癌関連線維芽細胞(CAF)前駆細胞とされるヒト膵癌由来膵星細胞(hPSC-5)，マウス膵癌細胞株(PAN 02)を標的細胞とした．膵癌細胞に結合性を有するレクチンrBC2LC-N，抗ヒト/マウスfibroblast-associated protein(FAP)抗体，IRDye700DX NHS esterを用いて複合体を作製し，cetuximab-IR700複合体(Akalux)と代謝拮抗薬gemcitabineも使用した．蛍光顕微鏡下で複合体の結合とNIR-PITでの細胞死を定性的に評価し，flowcytometryで定量的評価を行った．ヒト膵癌細胞株とhPSC-5，もしくはPAN 02をマウス皮下に移植した腫瘍モデルを作成し，NIR-PIT効果を確認した．
結果：蛍光顕微鏡下およびflowcytometryにおける検証では，rBC2LC-N-IR700はPanc04.03，Capan-1に良好に結合し，NIR-PITによって細胞死が得られた．Akaluxと各膵癌細胞株との結合性は低く，NIR-PITでの細胞死は得られなかった．一方で抗FAP抗体-IR700はhPSC-5に僅かに結合したが，NIR-PITでの有効な細胞死は得られなかった．各膵癌細胞株とhPSC-5を混合した腫瘍モデルにおいて，rBC2LC-N-IR700を用いたNIR-PITで著明な治療効果はみられたが，抗FAP抗体-IR700の上乗せ効果はなく，Akaluxを用いたNIR-PITの治療効果はみられなかった．PAN 02を皮下移植したモデルに対してgemcitabine投与と抗FAP抗体-IR700によるNIR-PITを行ったところ，抗FAP抗体-IR700の治療上乗せ効果がみられた．
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, Principal investigator, 23K07367 - 胆道癌患者における腫瘍内，胆汁中の細菌叢と化学療法への抵抗性／予後との関連
科学研究費助成事業
Aug. 2022 - Mar. 2024
杉浦諒; 桑谷将城; 川久保和道; 川本泰之
胆道癌は，根治切除割合は低く，緩和的化学療法も十分でないことから難治性悪性腫瘍の一つとされる．近年，細菌叢（マイクロバイオーム）と様々な疾患との関連が明らかになっているが，胆道癌においては免疫チェックポイント阻害薬の効果，治療抵抗性と糞便内マイクロバイオームとの関連性が報告されているのみである．胆道癌腫瘍内および胆汁中マイクロバイオームと殺細胞性抗癌剤や免疫チェックポイント阻害薬への抵抗性，予後への関与について検討した研究はない．したがって，本研究では胆道癌患者から得られた腫瘍生検検体および胆汁中のマイクロバイオームと化学療法（殺細胞性抗癌剤，あるいは殺細胞性抗癌剤+免疫チェックポイント阻害薬）への抵抗性や予後との関連を明らかにすることを目的とする．それらの関連性が明らかになることで，治療薬剤の選択や，マイクロバイオームに関連した新薬創薬標的の探索研究へ繋げられる可能性がある．
本研究では，目標症例数を40例とし，当該施設での倫理審査を得て，2023年2月から検体収集を開始した．腫瘍内細菌の由来を検討するため，内視鏡的逆行性胆管膵管造影検査（ERCP）に続いて行われる鉗子生検によって得られる生検検体と胆汁を収集している．2023年3月31日までで仮登録を含めて5例の検体収集をおこなっており，引き続き検体採取を行っている．
今後，検体が揃い次第，順次，16S rRNA領域を次世代シーケンサーと菌叢解析ツールを用いて解析し，検体内に棲息するマイクロバイオームを網羅的に同定する。また，診療録から得られる、対象者の基本情報、血液検査所見、画像検査所見、治療情報・アウトカム（無増悪生存期間，全生存期間）等との関連を検討する．
日本学術振興会, 研究活動スタート支援, 北海道大学, Coinvestigator not use grants, 22K20907 - 膵外分泌機能を評価する血液バイオマーカーを用いた膵がんリスク疾患・早期膵がんの診断法の臨床開発
革新的がん医療実用化研究事業
Apr. 2021 - Mar. 2024
本田一文; 小西宏; 井戸章雄; 坪内博仁; 桑谷将城; 小畑大輔; 長島健悟; 吉田寛; 岩切勝彦; 宮本美津子
国立研究開発法人日本医療研究開発機構（AMED）, Coinvestigator, 21443942 - Endoscopic ultrasound-guided through-the-needle-biopsy for the diagnosis of pancreatic cystic neoplasms
Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
Apr. 2015 - Mar. 2017
Kawakubo Kazumichi; MITSUHASHI Tomoko; MIZUKAMI Yusuke; ONO Yusuke; KUWATANI Masaki
Endoscopic ultrasonography-guided through-the-needle cyst wall biopsy (EUS-TNCB) was performed in two patients. A 71-year-old female had 32mm cystic lesion in the head of the pancreas. EUS-TNCB revealed fragmented epithelial cells with small nucleus with interstitial fibrotic tissue. A 48-year-old male had 20mm cystic lesion in the body of the pancreas. EUS-TNCB revealed no epithelial cells but interstitial fibrotic tissue. Gene mutation analysis by next-generation sequencer could not detect any mutation in both samples.
Japan Society for the Promotion of Science, Grant-in-Aid for Young Scientists (B), Hokkaido University, Coinvestigator not use grants, 15K19301 - Effect of fetal membrane-derived mesenchymal stem cells in rats with acute pancreatitis
Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
2012 - 2014
KUWATANI Masaki; KAWAKUBO Kazumichi; OHNISHI Shunsuke
Objectives: We investigated the effect of rat FM-derived mesenchymal stem cells (FM-MSCs) and human amnion-derived MSCs (AMSCs) on the therapeutic effects in rats with acute and chronic pancreatitis.
Methods: Acute pancreatitis was induced by intraductal injection of taurocholate, and rat FM-MSCs were transplanted intravenously. Chronic pancreatitis was induced by intravenous injection of 5 mg/kg dibutyltin dichloride, and human AMSCs were transplanted intravenously.
Results: Transplantation of rat FM-MSCs significantly reduced the histological score and infiltration of CD68-positive macrophages in the rat pancreas. Human AMSC transplantation significantly decreased the expression of MCP-1 and attenuated the downregulation of amylase expression in the pancreas. Conclusions: Transplantation of FM-MSCs and AMSCs suppressed the inflammatory reaction of acute and chronic pancreatitis in rats.
Japan Society for the Promotion of Science, Grant-in-Aid for Young Scientists (B), Hokkaido University, Principal investigator, Competitive research funding, 24790670
