Researcher Profile and Settings

Affiliation

• Faculty of Health Sciences　Health Sciences　Department of Rehabilitation Science

Job Title

• Associate Professor

Degree

• Master of Health Sciences（2014/03 Hokkaido University）
• Doctor of Health Sciences（2018/03 Hokkaido University）

J-Global ID

• 201901000589506800

Research Interests

• rehabilitation   Movement Disorders   Parkinson's Disease   Neurorehabilitation   Motor Learning   Postural Control   

Research Areas

• Life sciences / Neuroscience - general
• Life sciences / Sports science
• Life sciences / Rehabilitation science

Educational Organization

•  Bachelor's degree program　Departments of Health Sciences, School of Medicine
•  Master's degree program　Graduate School of Health Sciences
•  Doctoral (PhD) degree program　Graduate School of Health Sciences

Academic & Professional Experience

• 2022/05 - Today Sapporo Yamanoue Hospital Department of Rehabilitation Physical Therapist
• 2022/04 - Today Hokkaido University Faculty of Health Sciences Associate Professor
• 2020/05 - 2022/03 Hokkaido University Faculty of Health Sciences Assistant Professor
• 2019/09 - 2022/03 Aozora Clinic Department of Rehabilitation Physical Therapist
• 2019/10 - 2020/04 Hokkaido University Faculty of Health Sciences
• 2018/07 - 2019/08 Oregon Health and Science University Balance Disorders Lab Postdoctoral Fellow
• 2018/04 - 2018/12 Hokkaido University Faculty of Health Sciences
• 2018/01 - 2018/07 Aozora Clinic Department of Rehabilitaion Physical Therapist
• 2012/04 - 2017/12 Sapporo Yamanoue Hospital Department of Rehabilitaion Physical Therapist

Education

• 2014/04 - 2018/03  Hokkaido University  Department of Health Sciences
• 2012/04 - 2014/03  Hokkaido University  Department of Health Sciences
• 2008/04 - 2012/03  Hokkaido University  School of Medicine  Department of Health Sciences

Association Memberships

• 日本神経理学療法学会   日本基礎理学療法学会   International Society of Posture & Gait Research   International Parkinson and Movement Disorder Society   Society for Neuroscience   北海道理学療法士協会   JAPANESE PHYSICAL THERAPY ASSOCIATION   

Research Activities

Published Papers

• Digital measures of freezing of gait across the spectrum of normal, non-freezers, possible freezers and definite freezers.

  Martina Mancini, Naoya Hasegawa, Daniel S Peterson, Fay B Horak, John G Nutt

  Journal of neurology 270 (9) 4309 - 4317 2023/09 

  Over the course of the disease, freezing of gait (FoG) will gradually impact over 80% of people with Parkinson's disease (PD). Clinical decision-making and research design are often based on classification of patients as 'freezers' or 'non-freezers'. We derived an objective measure of FoG severity from inertial sensors on the legs to examine the continuum of FoG from absent to possible and severe in people with PD and in healthy controls. One hundred and forty-seven people with PD (Off-medication) and 83 healthy control subjects turned 360° in-place for 1 minute while wearing three wearable sensors used to calculate a novel Freezing Index. People with PD were classified as: 'definite freezers', new FoG questionnaire (NFOGQ) score > 0 and clinically observed FoG; 'non-freezers', NFOGQ = 0 and no clinically observed FoG; and 'possible freezers', either NFOGQ > 0 but no FoG observed or NFOGQ = 0 but FoG observed. Linear mixed models were used to investigate differences in participant characteristics among groups. The Freezing Index significantly increased from healthy controls to non-freezers to possible freezers and to definite freezers and showed, in average, excellent test-retest reliability (ICC = 0.89). Unlike the Freezing Index, sway, gait and turning impairments were similar across non-freezers, possible and definite freezers. The Freezing Index was significantly related to NFOG-Q, disease duration, severity, balance confidence, and the SCOPA-Cog (p < 0.01). An increase in the Freezing Index, objectively assessed with wearable sensors during a turning- in-place test, may help identify prodromal FoG in people with PD prior to clinically-observable or patient-perceived freezing. Future work should follow objective measures of FoG longitudinally.
• Effects of the Loss of Binocular and Motion Parallax on Static Postural Stability.

  Keita Ishikawa, Naoya Hasegawa, Ayane Yokoyama, Yusuke Sakaki, Hiromasa Akagi, Ami Kawata, Hiroki Mani, Tadayoshi Asaka

  Sensors (Basel, Switzerland) 23 (8) 2023/04/20 [Refereed][Invited]
   

  Depth information is important for postural stability and is generated by two visual systems: binocular and motion parallax. The effect of each type of parallax on postural stability remains unclear. We investigated the effects of binocular and motion parallax loss on static postural stability using a virtual reality (VR) system with a head-mounted display (HMD). A total of 24 healthy young adults were asked to stand still on a foam surface fixed on a force plate. They wore an HMD and faced a visual background in the VR system under four visual test conditions: normal vision (Control), absence of motion parallax (Non-MP)/binocular parallax (Non-BP), and absence of both motion and binocular parallax (Non-P). The sway area and velocity in the anteroposterior and mediolateral directions of the center-of-pressure displacements were measured. All postural stability measurements were significantly higher under the Non-MP and Non-P conditions than those under the Control and Non-BP conditions, with no significant differences in the postural stability measurements between the Control and Non-BP conditions. In conclusion, motion parallax has a more prominent effect on static postural stability than binocular parallax, which clarifies the underlying mechanisms of postural instability and informs the development of rehabilitation methods for people with visual impairments.
• 【システムとしての姿勢制御-メカニズムの解明から臨床応用まで】聴覚フィードバックを用いた姿勢制御アプローチ

  長谷川 直哉

  理学療法ジャーナル (株)医学書院 57 (3) 306 - 312 0915-0552 2023/03 [Invited]
   

  ＜文献概要＞Point ●感覚フィードバック練習に用いられる代表的感覚は,視覚,聴覚,体性感覚である●聴覚フィードバックには,聴覚キュー,アラーム刺激,sonificationがあり,近年はsonificationを用いた研究が増加している●聴覚フィードバック練習では固有受容覚との強いリンクが示唆され,運動学習に有利な可能性がある
• Effects of a Cognitively Challenging Agility Boot Camp Program on Balance and Gait in People With Parkinson's Disease: Does Freezing of Gait Status Matter?

  Vrutangkumar V Shah, Rodrigo Vitorio, Naoya Hasegawa, Patricia Carlson-Kuhta, John G Nutt, Laurie A King, Martina Mancini, Fay B Horak

  Neurorehabilitation and neural repair 15459683221119757 - 15459683221119757 2022/08/25 [Refereed][Not invited]
   

  BACKGROUND AND AIM: Individuals with Parkinson's disease (PD) with and without freezing of Gait (FoG) may respond differently to exercise interventions for several reasons, including disease duration. This study aimed to determine whether both people with and without FoG benefit from the Agility Boot Camp with Cognitive Challenges (ABC-C) program. METHODS: This secondary analysis of our ABC-C trial included 86 PD subjects: 44 without FoG (PD-FoG) and 42 with FoG (PD + FoG). We collected measures of standing sway balance, anticipatory postural adjustments, postural responses, and a 2-minute walk with and without a cognitive task. Two-way repeated analysis of variance, with disease duration as covariate, was used to investigate the effects of ABC-C program. Effect sizes were calculated using standardized response mean (SRM) for PD-FoG and PD + FoG, separately. RESULTS: The ABC-C program was effective in improving gait performance in both PD-FoG and PD + FoG, even after controlling for disease duration. Specifically, dual-task gait speed (P < .0001), dual-cost stride length (P = .012), and these single-task measures: arm range of motion (P < .0001), toe-off angle (P = .005), gait cycle duration variability (P = .019), trunk coronal range of motion (P = .042), and stance time (P = .046) improved in both PD-FoG and PD + FoG. There was no interaction effect between time (before and after exercise) and group (PD-FoG/PD + FoG) in all 24 objective measures of balance and gait. Dual-task gait speed improved the most in PD + FoG (SRM = 1.01), whereas single-task arm range of motion improved the most in PD-FoG (SRM = 1.01). CONCLUSION: The ABC-C program was similarly effective in improving gait (and not balance) performance in both PD-FoG and PD + FoG.
• Visual feedback in the lower visual field affects postural control during static standing

  Hiroki Mani, Norio Kato, Naoya Hasegawa, Yuto Urano, Takumi Aiko, Takaki Kurogi, Tadayoshi Asaka

  Gait & Posture 0966-6362 2022/07 [Refereed][Not invited]
  
• Factors Contributing to Repeated Falls in Patients with Parkinson’s Disease: Focusing on Falls Self-efficacy and Cognition of Punishment

  冨居泰臣, 冨居泰臣, 大槻美佳, 長谷川直哉

  高次脳機能研究 42 (1) 1348-4818 2022/03 [Refereed]
  
• Motor learning on postural control using auditory biofeedback training

  Naoya Hasegawa, Tadayoshi Asaka

  Impact 2021 (8) 55 - 57 2398-7073 2021/10/28 [Not refereed]
   

  Motor disorders are characterised by damage to the central nervous system, which subsequently affects muscles, motor skills and brain function. People with motor disorders can suffer injury as a result of falls and recovery from falls can be challenging. Augmented biofeedback modalities is an important tool used in physical therapy, providing individuals with biofeedback that helps guide them through the therapy. Biofeedback modalities have been designed for most of our senses, including auditory, visual and haptic and advances in technology have meant that biofeedback therapy can make use of wearable technology and future advances are expected to further assist. Therefore, it will be key to determine which biofeedback method works best for different training exercises and conditions in order to maximise the benefits of technological advances. Dr Naoya Hasegawa and Professor Tadayoshi Asaka are investigating which biofeedback method works best for different therapies. Their goal is to understand the characteristics of sensory modalities used for biofeedback training in order to help physical therapists determine appropriate approaches for different individuals. The researchers are currently investigating postural control with a view to defining the characteristics of postural control during walking and standing and developing new methods to enhance or improve it. This work involves the use of force plates, 3D motion analysis systems and electromyograms.
• Development of the Relationships Among Dynamic Balance Control, Inter-limb Coordination, and Torso Coordination During Gait in Children Aged 3–10 Years

  Hiroki Mani, Saori Miyagishima, Naoki Kozuka, Takahiro Inoue, Naoya Hasegawa, Tadayoshi Asaka

  Frontiers in Human Neuroscience 15 740509 - 740509 2021/10/28 [Refereed]
   

  Knowledge about the developmental process of dynamic balance control comprised of upper arms and upper legs coordination and trunk and pelvis twist coordination is important to advance effective balance assessment for abnormal development. However, the mechanisms of these coordination and stability control during gait in childhood are unknown.This study examined the development of dynamic postural stability, upper arm and upper leg coordination, and trunk and pelvic twist coordination during gait, and investigated the potential mechanisms integrating the central nervous system with inter-limb coordination and trunk and pelvic twist coordination to control extrapolated center of the body mass (XCOM). This study included 77 healthy children aged 3–10 years and 15 young adults. The child cohort was divided into four groups by age: 3–4, 5–6, 7–8, and 9–10 years. Participants walked barefoot at a self-selected walking speed along an 8 m walkway. A three-dimensional motion capture system was used for calculating the XCOM, the spatial margin of stability (MoS), and phase coupling movements of the upper arms, upper legs, trunk, and pelvic segments. MoS in the mediolateral axis was significantly higher in the young adults than in all children groups. Contralateral coordination (ipsilateral upper arm and contralateral upper leg combination) gradually changed to an in-phase pattern with increasing age until age 9 years. Significant correlations of XCOM_ML with contralateral coordination and with trunk and pelvic twist coordination (trunk/pelvis coordination) were found. Significant correlations between contralateral coordination and trunk/pelvis coordination were observed only in the 5–6 years and at 7–8 years groups.Dynamic postural stability during gait was not fully mature at age 10. XCOM control is associated with the development of contralateral coordination and trunk and pelvic twist coordination. The closer to in-phase pattern of contralateral upper limb coordination improved the XCOM fluctuations. Conversely, the out-of-phase pattern (about 90 degrees) of the trunk/pelvis coordination increased theXCOM fluctuation. Additionally, a different control strategy was used among children 3–8 years of age and individuals over 9 years of age, which suggests that 3–4-year-old children showed a disorderly coordination strategy between limb swing and torso movement, and in children 5–8 years of age, limb swing depended on trunk/pelvis coordination.
• Chopstick operation training with the left non-dominant hand

  Daisuke Sawamura, Satoshi Sakuraba, Kazuki Yoshida, Naoya Hasegawa, Yumi Suzuki, Susumu Yoshida, Toshihiro Honke, Shinya Sakai

  Translational Neuroscience 12 (1) 385 - 395 2021/10/22 

  Training a non-dominant hand is important for rehabilitating people who are required to change handedness. However, improving the dexterity in using chopsticks with a non-dominant hand through training remains unclear. This study is aimed to measure whether chopstick training improves non-dominant hand chopstick operation skills and leads to acquisition of skill levels similar to those of the dominant hand. This single-blinded randomized controlled trial enrolled 34 healthy young right-handed subjects who scored >70 points on the Edinburgh Handedness Questionnaire Inventory. They were randomly allocated to training or control groups. The training group participated in a 6-week chopstick training program with the non-dominant left hand, while the control group did not. Asymmetry of chopstick operation skill, perceived psychological stress, and oxygen-hemoglobin concentration as a brain activity measure in each hemisphere were measured before and after training. Participants in the training group had significantly lower asymmetry than those in the control group during the post-training assessment (F[1,30] ≥ 5.54, p ≤ 0.03, partial η ² ≥ 0.156). Only perceived psychological stress had a significantly higher asymmetry during the post-training assessment (t[15] = 3.81, p < 0.01). Six weeks of chopstick training improved non-dominant chopstick operation skills, and a performance level similar to that of the dominant hand was acquired.
• 運動学習(11)各論(2)パーキンソン病患者に対する運動学習理論を応用した理学療法の展開

  長谷川 直哉

  理学療法 メディカルプレス 38 (9) 843 - 850 0910-0059 2021/09 [Invited]
  
• Effects on forward stability limits by floating toes during standing

  Ayane Yokoyama, Hiroki Mani, Naoya Hasegawa, Shenlei Tang, Yasuyuki Takamatsu, Tadayoshi Asaka

  Health and Behavior Sciences 日本健康行動科学会 20 (1) 13 - 18 1348-0898 2021/09 [Refereed]
  
• Adaptation of the Compensatory Stepping Response Following Predictable and Unpredictable Perturbation Training.

  Naoya Hasegawa, Shintaro Tanaka, Hiroki Mani, Takahiro Inoue, Yun Wang, Kazuhiko Watanabe, Tadayoshi Asaka

  Frontiers in human neuroscience 15 674960 - 674960 2021/06/15 [Refereed]
   

  Background: Effective training of the backward step response could be beneficial to improve postural stability and prevent falls. Unpredicted perturbation-based balance training (PBT), widely known as compensatory-step training, may enhance the fear of falling and the patterns of postural muscle co-contraction. Contrastingly, PBT with predictable direction or both direction and timing would suppress the fear and the co-contraction patterns during training, but the efficacy of predictable PBT for unpredictable perturbations is still unknown. Objective: To compare the adaptation effects of compensatory-step training with and without predictable perturbations on backward stepping against unpredictable perturbations. Methods: Thirty-three healthy young adults were randomly assigned to one of the following step training groups: Unpredicted, Predicted, and Self-initiated. In training sessions, participants were perturbed to induce a compensatory step with (Predicted group) or without (Unpredicted group) knowledge of the perturbation's direction or while knowing both the direction and timing of the perturbation (Self-initiated group). In test sessions (pre- and post-training), participants were instructed to recover their postural stability in response to an unpredicted perturbation. The margin of stability (MOS), center of mass (COM) shift, and step characteristics were measured during a backward step in both test and training sessions. Results: All three groups showed a significant increase in the step length and velocity in the post-training sessions compared to those in the pre-training sessions. Moreover, in the Unpredicted and Predicted groups, but not in the Self-initiated group, the MOS at step contact was significantly increased following the training session. In addition, the Self-initiated group showed a significant increase in COM shift at 50 ms after slip onset during training compared to the Unpredicted and Predicted groups. Conclusion: Unpredicted and predicted PBT improve step characteristics during backward stepping against unpredictable perturbations. Moreover, the unpredictable PBT and PBT with direction-predictable perturbations enhance the feedback postural control reflected as the postural stability at step contact.
• Specific inhibition of α5 subunit-containing GABAA receptors enhances locomotor activity and neuronal activity in the motor cortex.

  Takahiro Inoue, Yasuyuki Takamatsu, Misato Okamura, Hiroki Mani, Naoya Hasegawa, Hiroshi Maejima

  Biomedical research (Tokyo, Japan) 42 (3) 103 - 108 2021/06/07 [Refereed]
   

  Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter in the central nervous system (CNS). This study examined the effect of specific inhibition of α5 subunit-containing GABAA receptors (α5GABAAR) on the behavioral profile and neuronal activity of the CNS using a compound called L-655,708, which is a selective negative allosteric modulator of α5GABAAR. L-655,708 administration significantly increased locomotor activity without anxiety-related behavior. Furthermore, L-655,708 administration significantly increased c-Fos mRNA expression (a neuronal activity marker) in motor area of the cerebral cortex, whereas it hardly altered c-Fos mRNA expression in the sensory cortex, hippocampus, and spinal cord. This study revealed for the first time that alteration of neuronal activity with specific inhibition of α5GABAAR differs depending on each CNS region. α5GABAAR could be a potential target for modulating CNS excitability and behavioral activity.
• Functional limits of stability and standing balance in people with Parkinson's disease with and without freezing of gait using wearable sensors.

  Naoya Hasegawa, Kas C Maas, Vrutangkumar V Shah, Patricia Carlson-Kuhta, John G Nutt, Fay B Horak, Tadayoshi Asaka, Martina Mancini

  Gait & posture 87 123 - 129 2021/04/19 [Refereed]
   

  BACKGROUND: People with from Parkinson's disease (PD) and freezing of gait (FoG) have more frequent falls compared to those who do not freeze but there is no consensus on which, specific objective measures of postural instability are worse in freezers (PD + FoG) than non-freezers (PD-FoG). RESEARCH QUESTION: Are functional limits of stability (fLoS) or postural sway during stance measured with wearable inertial sensors different between PD + FoG versus PD-FoG, as well as between PD versus healthy control subjects (HC)? METHODS: Sixty-four PD subjects with FoG (MDS-UPDRS Part III: 45.9 ± 12.5) and 80 PD subjects without FoG (MDS-UPDRS Part III: 36.2 ± 10.9) were tested Off medication and compared with 79 HC. Balance was quantified with inertial sensors worn on the lumbar spine while performing the following balance tasks: 1) fLoS as defined by the maximum displacement in the forward and backward directions and 2) postural sway area while standing with eyes open on a firm and foam surface. An ANOVA, controlling for disease duration, compared postural control between groups. RESULTS: PD + FoG had significantly smaller fLoS compared to PD-FoG (p =  0.004) and to healthy controls (p <  0.001). However, PD-FoG showed similar fLoS compared to healthy controls (p =  0.48). Both PD+FoG and PD-FoG showed larger postural sway on a foam surface compared to healthy controls (p =  0.001) but there was no significant difference in postural sway between PD+FoG and PD-FoG. SIGNIFICANCE: People with PD and FoG showed task-specific, postural impairments with smaller fLoS compared to non-freezers, even when controlling for disease duration. However, individuals with PD with or without FoG had similar difficulties standing quietly on an unreliable surface compared to healthy controls. Wearable inertial sensors can reveal worse fLoS in freezers than non-freezers that may contribute to FoG and help explain their more frequent falls.
• Effects of simulated peripheral visual field loss on the static postural control in young healthy adults.

  Kenji Taneda, Hiroki Mani, Norio Kato, Shunsuke Komizunai, Keita Ishikawa, Takashi Maruya, Naoya Hasegawa, Yasuyuki Takamatsu, Tadayoshi Asaka

  Gait & posture 86 233 - 239 2021/03/10 [Refereed]
   

  BACKGROUND: Integration of visual, vestibular, and proprioceptive sensations contributes to postural control. People with peripheral visual field loss have serious postural instability. However, the directional specificity of postural stability and sensory reweighting caused by gradual peripheral visual field loss remain unclear. RESEARCH QUESTION: What are the effects of peripheral visual field loss on static postural control? METHODS: Fifteen healthy young adults participated in this study. The participants were asked to stand quietly on a foam surface. Three conditions of virtual visual field loss (90°, 45°, and 15°) were provided by a head-mounted display, and ground reaction forces were collected using a force plate to calculate the displacements of the center of pressure (COP). RESULTS: The root mean square (RMS), mean velocity, and 95% ellipse area of COP displacements in the horizontal plane increased, and RMS in the anteroposterior (AP) direction was unchanged under the smallest visual field condition compared to the largest one. The power spectrum density of COP displacements in the low-frequency band was decreased and that in the medium-frequency band was increased in the AP direction. SIGNIFICANCE: During quiet standing of young healthy adults with peripheral visual field loss, increased peripheral visual field loss resulted in lower postural stability. Postural stability in the AP direction was maintained contrary to the functional sensitivity hypothesis. Peripheral visual field loss reduced the weighting of the visual input and increased that of the vestibular input in the AP direction to maintain equilibrium.
• Dual-Task Costs of Quantitative Gait Parameters While Walking and Turning in People with Parkinson's Disease: Beyond Gait Speed.

  Rodrigo Vitorio, Naoya Hasegawa, Patricia Carlson-Kuhta, John G Nutt, Fay B Horak, Martina Mancini, Vrutangkumar V Shah

  Journal of Parkinson's disease 2020/12/29 [Refereed]
   

  BACKGROUND: There is a lack of recommendations for selecting the most appropriate gait measures of Parkinson's disease (PD)-specific dual-task costs to use in clinical practice and research. OBJECTIVE: We aimed to identify measures of dual-task costs of gait and turning that best discriminate performance in people with PD from healthy individuals. We also investigated the relationship between the most discriminative measures of dual-task costs of gait and turning with disease severity and disease duration. METHODS: People with mild-to-moderate PD (n = 144) and age-matched healthy individuals (n = 79) wore 8 inertial sensors while walking under single and dual-task (reciting every other letter of the alphabet) conditions. Outcome measures included 26 objective measures within four gait domains (upper/lower body, turning and variability). The area under the curve (AUC) from the receiver-operator characteristic plot was calculated to compare discriminative ability of dual-task costs on gait across outcome measures. RESULTS: PD-specific, dual-task interference was identified for arm range of motion, foot strike angle, turn velocity and turn duration. Arm range of motion (AUC = 0.73) and foot strike angle (AUC = 0.68) had the largest AUCs across dual-task costs measures and they were associated with disease severity and/or disease duration. In contrast, the most commonly used dual-task gait measure, gait speed, showed an AUC of only 0.54. CONCLUSION: Findings suggest that people with PD rely more than healthy individuals on executive-attentional resources to control arm swing, foot strike, and turning, but not gait speed. The dual-task costs of arm range of motion best discriminated people with PD from healthy individuals.
• Differential effects of visual versus auditory biofeedback training for voluntary postural sway.

  Naoya Hasegawa, Kenta Takeda, Martina Mancini, Laurie A King, Fay B Horak, Tadayoshi Asaka

  PloS one 15 (12) e0244583  2020/12/28 [Refereed]
   

  Augmented sensory biofeedback training is often used to improve postural control. Our previous study showed that continuous auditory biofeedback was more effective than continuous visual biofeedback to improve postural sway while standing. However, it has also been reported that both discrete visual and auditory biofeedback training, presented intermittently, improves bimanual task performance more than continuous visual biofeedback training. Therefore, this study aimed to investigate the relative effectiveness of discrete visual biofeedback versus discrete auditory biofeedback to improve postural control. Twenty-two healthy young adults were randomly assigned to either a visual or auditory biofeedback group. Participants were asked to shift their center of pressure (COP) by voluntary postural sway forward and backward in line with a hidden target, which moved in a sinusoidal manner and was displayed intermittently. Participants were asked to decrease the diameter of a visual circle (visual biofeedback) or the volume of a sound (auditory biofeedback) based on the distance between the COP and the target in the training session. The feedback and the target were given only when the target reached the inflection points of the sine curves. In addition, the perceptual magnitudes of visual and auditory biofeedback were equalized using Stevens' power law. Results showed that the mean and standard deviation of the distance between COP and the target were reduced int the test session, removing the augmented sensory biofeedback, in both biofeedback training groups. However, the temporal domain of the performance improved in the test session in the auditory biofeedback training group, but not in the visual biofeedback training group. In conclusion, discrete auditory biofeedback training was more effective for the motor learning of voluntarily postural swaying compared to discrete visual biofeedback training, especially in the temporal domain.
• Effects of the agility boot camp with cognitive challenge (ABC-C) exercise program for Parkinson's disease.

  Se Hee Jung, Naoya Hasegawa, Martina Mancini, Laurie A King, Patricia Carlson-Kuhta, Katrijn Smulders, Daniel S Peterson, Nancy Barlow, Graham Harker, Rosie Morris, Jodi Lapidus, John G Nutt, Fay B Horak

  NPJ Parkinson's disease 6 (1) 31 - 31 2020/11/02 [Refereed]
   

  Few exercise interventions practice both gait and balance tasks with cognitive tasks to improve functional mobility in people with PD. We aimed to investigate whether the Agility Boot Camp with Cognitive Challenge (ABC-C), that simultaneously targets both mobility and cognitive function, improves dynamic balance and dual-task gait in individuals with Parkinson's disease (PD). We used a cross-over, single-blind, randomized controlled trial to determine efficacy of the exercise intervention. Eighty-six people with idiopathic PD were randomized into either an exercise (ABC-C)-first or an active, placebo, education-first intervention and then crossed over to the other intervention. Both interventions were carried out in small groups led by a certified exercise trainer (90-min sessions, 3 times a week, for 6 weeks). Outcome measures were assessed Off levodopa at baseline and after the first and second interventions. A linear mixed-effects model tested the treatment effects on the Mini-BESTest for balance, dual-task cost on gait speed, SCOPA-COG, the UPDRS Parts II and III and the PDQ-39. Although no significant treatment effects were observed for the Mini-BESTest, SCOPA-COG or MDS-UPDRS Part III, the ABC-C intervention significantly improved the following outcomes: anticipatory postural adjustment sub-score of the Mini-BESTest (p = 0.004), dual-task cost on gait speed (p = 0.001), MDS-UPDRS Part II score (p = 0.01), PIGD sub-score of MDS-UPDRS Part III (p = 0.02), and the activities of daily living domain of the PDQ-39 (p = 0.003). Participants with more severe motor impairment or more severe cognitive dysfunction improved their total Mini-BESTest scores after exercise. The ABC-C exercise intervention can improve specific balance deficits, cognitive-gait interference, and perceived functional independence and quality of life, especially in participants with more severe PD, but a longer period of intervention may be required to improve global cognitive and motor function.
• Responsiveness of Objective vs. Clinical Balance Domain Outcomes for Exercise Intervention in Parkinson's Disease.

  Naoya Hasegawa, Vrutangkumar V Shah, Graham Harker, Patricia Carlson-Kuhta, John G Nutt, Jodi A Lapidus, Se Hee Jung, Nancy Barlow, Laurie A King, Fay B Horak, Martina Mancini

  Frontiers in neurology 11 940 - 940 2020/09/25 [Refereed]
   

  Background: Balance deficits in people with Parkinson's disease (PD) are often not helped by pharmacological or surgical treatment. Although balance exercise intervention has been shown to improve clinical measures of balance, the efficacy of exercise on different, objective balance domains is still unknown. Objective: To compare the sensitivity to change in objective and clinical measures of several different domains of balance and gait following an Agility Boot Camp with Cognitive Challenges (ABC-C) intervention. Methods: In this cross-over, randomized design, 86 individuals with PD participated in 6-week (3×/week) ABC-C exercise classes and 6-week education classes, consisting of 3-6 individuals. Blinded examiners tested people in their practical off state. Objective outcome measures from wearable sensors quantified four domains of balance: sway in standing balance, anticipatory postural adjustments (APAs) during step initiation, postural responses to the push-and-release test, and a 2-min natural speed walk with and without a cognitive task. Clinical outcome measures included the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part III, the Mini Balance Evaluation Systems Test (Mini-BESTest), the Activities of Balance Confidence (ABC), and the Parkinson's Disease Questionnaire (PDQ-39). The standardized response means (SRM) of the differences between before and after each intervention compared responsiveness of outcomes to intervention. A linear mixed model compared effects of exercise with the active control-education intervention. Results: The most responsive outcome measures to exercise intervention with an SRM > 0.5 were objective measures of gait and APAs, specifically arm range of motion, gait speed during a dual-task walk, trunk coronal range of motion, foot strike angle, and first-step length at step initiation. The most responsive clinical outcome measure was the patient-reported PDQ-39 activities daily living subscore, but all clinical measures had SRMs <0.5. Conclusions: The objective measures were more sensitive to change after exercise intervention compared to the clinical measures. Spatiotemporal parameters of gait, including gait speed with a dual task, and APAs were the most sensitive objective measures, and perceived functional independence was the most sensitive clinical measure to change after the ABC-C exercise intervention. Future exercise intervention to improve gait and balance in PD should include objective outcome measures.
• Short-term effects of postural control by standing on a tilting board in patients with Parkinson's disease.

  Naoya Hasegawa, Keita Ishikawa, Yuki Sato, Yasuhide Nakayama, Tadayoshi Asaka

  Physiotherapy theory and practice 37 (12) 1 - 7 0959-3985 2019/11/26 [Refereed][Not invited]
   

  Background: People with Parkinson's disease (PD) often have backward displacement of their center of pressure (COP) during quiet standing and reduced stability limits, as compared to healthy controls. These kinetic characteristics may induce postural instability in people with PD.Objective: To investigate the short-term effects on COP displacements during quiet standing and forward leaning brought about by the post-incline leaning after-effects in people with PD.Methods: Twenty participants with PD were randomly divided into two groups (tilting and control groups). The tilting group was required to stand upright quietly on a tilting board angled to raise the front part of the feet. The control group was asked to voluntarily lean their bodies forward as far as possible. The total time of the intervention was 60 seconds for each group. The COP displacements during quiet standing and forward leaning were recorded before and after the intervention.Results: In the tilting group, the COP significantly shifted forward after the intervention compared to that before the intervention during quiet standing as well as forward stability limits; this did not happen in the control group.Conclusions: The post-incline leaning after-effects may induce the short-term effects of forward shifting of COP during quiet standing and expand the forward stability limits in people with PD.
• How to Select Balance Measures Sensitive to Parkinson's Disease from Body-Worn Inertial Sensors-Separating the Trees from the Forest.

  Naoya Hasegawa, Vrutangkumar V Shah, Patricia Carlson-Kuhta, John G Nutt, Fay B Horak, Martina Mancini

  Sensors (Basel, Switzerland) 19 (15) 2019/07/28 [Refereed][Invited]
   

  This study aimed to determine the most sensitive objective measures of balance dysfunction that differ between people with Parkinson's Disease (PD) and healthy controls. One-hundred and forty-four people with PD and 79 age-matched healthy controls wore eight inertial sensors while performing tasks to measure five domains of balance: standing posture (Sway), anticipatory postural adjustments (APAs), automatic postural responses (APRs), dynamic posture (Gait) and limits of stability (LOS). To reduce the initial 93 measures, we selected uncorrelated measures that were most sensitive to PD. After applying a threshold on the Standardized Mean Difference between PD and healthy controls, 44 measures remained; and after reducing highly correlated measures, 24 measures remained. The four most sensitive measures were from APAs and Gait domains. The random forest with 10-fold cross-validation on the remaining measures (n = 24) showed an accuracy to separate PD from healthy controls of 82.4%-identical to result for all measures. Measures from the most sensitive domains, APAs and Gait, were significantly correlated with the severity of disease and with patient-related outcomes. This method greatly reduced the objective measures of balance to the most sensitive for PD, while still capturing four of the five domains of balance.
• Learning effects of dynamic postural control by auditory biofeedback versus visual biofeedback training.

  Naoya Hasegawa, Kenta Takeda, Moe Sakuma, Hiroki Mani, Hiroshi Maejima, Tadayoshi Asaka

  Gait & posture 58 188 - 193 0966-6362 2017/08/02 [Refereed][Not invited]
   

  Augmented sensory biofeedback (BF) for postural control is widely used to improve postural stability. However, the effective sensory information in BF systems of motor learning for postural control is still unknown. The purpose of this study was to investigate the learning effects of visual versus auditory BF training in dynamic postural control. Eighteen healthy young adults were randomly divided into two groups (visual BF and auditory BF). In test sessions, participants were asked to bring the real-time center of pressure (COP) in line with a hidden target by body sway in the sagittal plane. The target moved in seven cycles of sine curves at 0.23Hz in the vertical direction on a monitor. In training sessions, the visual and auditory BF groups were required to change the magnitude of a visual circle and a sound, respectively, according to the distance between the COP and target in order to reach the target. The perceptual magnitudes of visual and auditory BF were equalized according to Stevens' power law. At the retention test, the auditory but not visual BF group demonstrated decreased postural performance errors in both the spatial and temporal parameters under the no-feedback condition. These findings suggest that visual BF increases the dependence on visual information to control postural performance, while auditory BF may enhance the integration of the proprioceptive sensory system, which contributes to motor learning without BF. These results suggest that auditory BF training improves motor learning of dynamic postural control.
• Adaptation effects in static postural control by providing simultaneous visual feedback of center of pressure and center of gravity.

  Kenta Takeda, Hiroki Mani, Naoya Hasegawa, Yuki Sato, Shintaro Tanaka, Hiroshi Maejima, Tadayoshi Asaka

  Journal of physiological anthropology 36 (1) 31 - 31 1880-6791 2017/07/19 [Refereed][Not invited]
   

  BACKGROUND: The benefit of visual feedback of the center of pressure (COP) on quiet standing is still debatable. This study aimed to investigate the adaptation effects of visual feedback training using both the COP and center of gravity (COG) during quiet standing. METHODS: Thirty-four healthy young adults were divided into three groups randomly (COP + COG, COP, and control groups). A force plate was used to calculate the coordinates of the COP in the anteroposterior (COPAP) and mediolateral (COPML) directions. A motion analysis system was used to calculate the coordinates of the center of mass (COM) in both directions (COMAP and COMML). The coordinates of the COG in the AP direction (COGAP) were obtained from the force plate signals. Augmented visual feedback was presented on a screen in the form of fluctuation circles in the vertical direction that moved upward as the COPAP and/or COGAP moved forward and vice versa. The COP + COG group received the real-time COPAP and COGAP feedback simultaneously, whereas the COP group received the real-time COPAP feedback only. The control group received no visual feedback. In the training session, the COP + COG group was required to maintain an even distance between the COPAP and COGAP and reduce the COGAP fluctuation, whereas the COP group was required to reduce the COPAP fluctuation while standing on a foam pad. In test sessions, participants were instructed to keep their standing posture as quiet as possible on the foam pad before (pre-session) and after (post-session) the training sessions. RESULTS: In the post-session, the velocity and root mean square of COMAP in the COP + COG group were lower than those in the control group. In addition, the absolute value of the sum of the COP - COM distances in the COP + COG group was lower than that in the COP group. Furthermore, positive correlations were found between the COMAP velocity and COP - COM parameters. CONCLUSIONS: The results suggest that the novel visual feedback training that incorporates the COPAP-COGAP interaction reduces postural sway better than the training using the COPAP alone during quiet standing. That is, even COPAP fluctuation around the COGAP would be effective in reducing the COMAP velocity.
• Characteristic Relationship between the Centre of Pressure and the Centre of Mass During Quiet Standing in Female Ballet Dancers

  Ibuki A, Mani H, Takeda K, Hasegawa N, Yamamoto K, Naejima H, Asaka T

  International Physical Medicine & Rehabilitation Journal 1 (2) 34 - 36 2574-9838 2017/05/18 [Refereed][Not invited]
  
• クロスステップ反復練習による片脚立位動作時の姿勢安定性への効果

  萬井 太規, 長谷川 直哉, 武田 賢太, 伊吹 愛梨, 佐久間 萌, 石川 啓太, 前島 洋, 浅賀 忠義

  理学療法科学 (一社)理学療法科学学会 31 (4) 601 - 607 1341-1667 2016/08 [Refereed][Not invited]
   

  [目的]本研究の目的は、クロスステップ反復練習の片脚立位時の姿勢安定性および姿勢戦略への即時効果を検証することである。[対象と方法]14人の健常若年者を対象とした。練習前後のテスト課題として、被験者は片脚立位姿勢を15秒保持した。練習課題は、クロスステップ動作を100回反復した。練習効果検証のため、足圧中心点(COP)から体重心(COM)までの距離(COP-COM間距離)、荷重量メカニズムとCOP位置メカニズムを算出した。[結果]練習後、片脚立位中のCOP-COM間距離は減少し、加速相で荷重量メカニズム、減速相でCOP位置メカニズムが増大した。[結語]クロスステップ練習は、姿勢戦略を変化させ、片脚立位中のCOP-COM間距離を近づける能力を高め、姿勢安定性を向上させることが示された。(著者抄録)
• Adaptation of postural control while standing on a narrow unfixed base of support.

  Hiroki Mani, Shih-Fen Hsiao, Tomoya Konishi, Tatsuya Izumi, Akiyo Tsuda, Naoya Hasegawa, Kenta Takeda, Noriyo Colley, Tadayoshi Asaka

  International journal of rehabilitation research. Internationale Zeitschrift fur Rehabilitationsforschung. Revue internationale de recherches de readaptation 39 (1) 92 - 5 0342-5282 2016/03 [Refereed][Not invited]
   

  The purpose of this study was to investigate the adaptation with practice of postural control while standing on a rocker board. Thirteen healthy young adults participated. The participants were asked to stand in a sagittal plane on a rocker board with a semicircular base as steadily as possible for as long as they could. With practice, the duration of maintaining postural balance increased significantly and postural stability improved (P<0.05). Furthermore, the distances between center of pressure and the projection of center of mass decreased (P<0.05), although joint motion of the lower extremities did not change (P>0.05). This observation would be the consequence of a highly redundant human locomotor system. With practice, the central nervous system was able to shift the center of pressure position close to the accurate center of mass position.
• パーキンソン病患者に対するトレッドミル後進歩行の効果について

  野村 恭平, 長谷川 直哉, 成田 雅

  理学療法学Supplement 公益社団法人 日本理学療法士協会 2015 924 - 924 2016 

  【はじめに，目的】パーキンソン病は，安静時振戦，筋固縮，寡動，姿勢反射障害を特徴とする慢性進行性の神経変性疾患である。パーキンソン病患者は，すくみ足による歩行障害や姿勢反射障害による転倒等により，身体活動量の低下や社会参加の減少，QOL低下をもたらす。そのため，パーキンソン病患者の歩行障害に対して，体重支持下でのトレッドミル歩行や聴覚，視覚，体性感覚刺激での歩行練習などが行われており，いずれも歩幅や歩行速度の改善を認めている。トレッドミル後進歩行についても先行研究により，歩幅や歩行速度の改善に対する有用性を示す報告がなされているが，各パラメーターに対する詳細な報告は演者たちが知る限りない。本研究は，携帯型歩行解析装置を用いて，トレッドミル後進歩行前後での歩行を行い，歩行の各パラメーターの比較，検討を行った。【方法】対象は，自立歩行が可能であり，整形外科的疾患や重篤な認知機能障害を有さないパーキンソン病患者8名（男性3名，女性5名，平均年齢69.5±6.7歳，身長156.4±8.1cm，体重59.2±9.4kg，Hoehn ＆ Yahr分類にてI度：3名，II度：5名，Unified Parkinson's Disease Rating Scale運動項目：21.0±9.3）だった。先行研究を参考に傾斜を3％設け，快適速度（0.6～1.6km/h）でのトレッドミル後進歩行を5分間実施した。トレッドミル後進歩行前後で携帯型歩行解析装置を装着し，10m歩行にて，歩行速度，歩幅，上下方向および左右方向の平均振幅と標準偏差，力強さ（G），パーキンソン症状が強い一側を悪側，弱い一側を良側として立脚期と遊脚期および両脚支持期の平均秒数と変動係数（CV）を算出した。統計解析は，介入前（pre）と介入後（post）の測定結果を比較するために，対応のあるt検定を実施し，有意水準は5％未満とした。【結果】トレッドミル後進歩行前後で，良側支持時間（pre：0.43±0.04，post：0.44±0.03），上下振幅の標準偏差（pre：0.2±0.1cm，post：0.3±0.1cm）で介入前後での有意な増加がみられ，その他のパラメーターに有意差は認めなかった。【結論】本研究は，パーキンソン病患者に対するトレッドミル後進歩行後の効果について，携帯型歩行解析装置を用いて検証した。先行研究によると，健常者と高齢者の通常歩行の比較では健常者の上下振幅の標準偏差が高いことが報告されている。本研究の結果では介入後に上下振幅の標準偏差が増加しており，これはより正常な歩行に近づいた結果であると考える。また，良側支持時間の増加は被験者にとってより困難な条件での練習により良側への依存度が高まった結果と考える。本研究の結果より，トレッドミル後進歩行練習はパーキンソン病患者の歩行をより正常に近づける可能性があることが示唆される。今後は症例数を重ねてより詳細な検証をしていく必要がある。
• 視覚フィードバックと聴覚フィードバックによる動的バランスの学習効果の違い

  長谷川 直哉, 萬井 太規, 武田 賢太, 佐久間 萌, 笠原 敏史, 浅賀 忠義

  理学療法学 (公社)日本理学療法士協会 42 (6) 474 - 479 0289-3770 2015/10 [Refereed][Not invited]
   

  【目的】随意的に荷重を移動させる動的バランスの課題を用いて、聴覚フィードバックと視覚フィードバックの学習効果を比較することだった。【方法】被験者は健常若年者20名とし、無作為に10名ずつ2群に割りあてた。被験者にはモニター上に写し出されたターゲットに、自身の足圧中心を前後に移動させて一致させるように指示した。練習ではターゲットの他に、足圧中心位置と連動して聴覚フィードバック(以下、聴覚群)または視覚フィードバック(以下、視覚群)が与えられた。正解性の指標として、足圧中心とターゲットとの間の距離の二乗平均平方根(以下、RMS)を算出した。【結果】両群ともに練習直後は、練習前と比較してRMSが有意に減少した。一方、練習後から1日経過後では、聴覚群でRMSの減少が持続していたが、視覚群では有意な増加がみられた。【結論】断続的な感覚フィードバックを用いた動的バランスにおいては、聴覚が視覚よりも運動学習に優れている。(著者抄録)
• Age-related changes in distance from center of mass to center of pressure during one-leg standing.

  Hiroki Mani, Shih-Fen Hsiao, Kenta Takeda, Naoya Hasegawa, Mitsuhisa Tozuka, Akiyo Tsuda, Tetsuro Ohashi, Tsukasa Suwahara, Kumiko Ito, Tadayoshi Asaka

  Journal of motor behavior 47 (4) 282 - 90 0022-2895 2015 [Refereed][Not invited]
   

  The purpose of this study was to clarify the age-related effects of distances from the center of pressure (COP) to the center of mass (COM) (COP-COM distances) during one-leg standing (OLS) task. Healthy old and young adults (n = 11 each) participated in this study. The authors divided the task into 3 phases (accelerated, decelerated, and steady) based on the relationship between COM and COP. COP-COM distances in the older group were significantly reduced during the accelerated phase, then significantly increased during the decelerated and steady phases. Furthermore, distances during these phases correlated inversely with OLS time. The authors conclude that OLS time is shortened by the larger braking response to COM shifts just after leg-lifting, and the production of larger inertial forces to maintain COM position during the OLS in older individuals.

Books etc

• 図解 理学療法検査・測定ガイド 第3版

  内山靖;長谷川直哉 (Joint work協調運動)
  文光堂 2023/02 (ISBN: 9784830647048) 395-409
• 理学療法評価学

  中山, 恭秀, 長谷川直哉 (Joint workバランス)
  メジカルビュー社 2022/03 (ISBN: 9784758320009) 19,409p 139-148
• Augmented Sensory Biofeedback for Dynamic Postural Control: Visual vs. Auditory

  Tadayoshi Asaka, Naoya Hasegawa (Joint work)
  Eliva Press 2021/03 (ISBN: 9789975154826) 46 46

Conference Activities & Talks

• 姿勢制御と運動学習 共催シンポジウム3 （日本前庭理学療法研究会 合同企画）「姿勢制御研究をどう臨床に活かすか」.  [Invited]

  長谷川直哉

  第21回日本神経理学療法学会学術大会  2023/09
• パーキンソン病患者の予測的姿勢調節の病態とそのアプローチ 公募型シンポジウム2「予測的姿勢調節の機能低下のメカニズムから今後の理学療法アプローチを考える」  [Invited]

  長谷川直哉

  第21回日本神経理学療法学会学術大会  2023/09
• Effects of useful field of view by cognitive loads for postural stability of a stable and unstable surface  [Not invited]

  Ami Kawata, Naoya Hasegawa

  ISPGR World Congress 2023  2023/07
• The effects by difference in difficulties of cognitive loads in dual-task training on performance of stepping task with cognitive loads  [Not invited]

  Yusuke Sakaki, Naoya Hasegawa

  ISPGR World Congress 2023  2023/07
• Impacts of a loss of binocular or motion parallax on static postural stability  [Not invited]

  Naoya Hasegawa

  ISPGR World Congress 2023  2023/07
• Integrated Allied Healthcare For Healthy Ageing: Interprofessional Collaborative Practice, Education and Research  [Not invited]

  Marianne Coleman, Naoya Hasegawa

  ANZAHPE 2023  2023/06
• パーキンソン病患者における定量的評価の有効性と臨床応用 シンポジウム 7 「基礎研究の臨床への還元 －パーキンソン病への理学療法－」  [Invited]

  長谷川直哉

  第27回日本基礎理学療法学会学術大会  2022/10
• The Role of A Physical Therapist in Medical Care  [Invited]

  Naoya Hasegawa

  Hokkaido University & The University of Melbourne Case Study Afternoon  2022/09
• An overview of Medical and Long-term Care System in Japan  [Invited]

  Naoya Hasegawa

  Hokkaido University & The University of Melbourne Case Study Afternoon  2022/09
• Adaptation effects of continuous and discrete visual feedback training on static postural control: a preliminary study  [Not invited]

  Naoya Hasegawa

  2022 ISPGR World Congress  2022/07  Montreal
• The different effects on motor learning for postural control using visual and auditory biofeedback training  [Invited]

  Naoya Hasegawa

  5th FHS International Conference  2021/09
• 在宅パーキンソン病患者の姿勢制御能力の評価に有効な指標の検討

  長谷川直哉

  第25回日本基礎理学療法学会学術大会  2020/12
• 在宅パーキンソン病患者に対する認知課題を伴うMultiple trainingが姿勢制御能力に与える効果

  長谷川直哉

  第18回日本神経理学療法学会学術大会  2020/11
• 断続的なフィードバック練習に用いる感覚の違いが姿勢バランス課題の運動学習に与える影響について  [Not invited]

  長谷川 直哉

  第24回日本基礎理学療法学会学術大会  2019/12
• Learning Effects of Visual and Auditory Feedback Training on Voluntarily Postural Control  [Not invited]

  Hasegawa N

  Neuroscience 2019  2019/10
• Effects of an agility exercise program with cognitive challenges on objective measures of gait and balance in people with Parkinson’s disease  [Not invited]

  Carlson-Kuhta P, Hasegawa N

  Neuroscience 2019  2019/10
• Multiple domains of postural control in Parkinson’s disease; feature selection of mobility measures  [Not invited]

  King LA, Hasegawa N

  Neuroscience 2019  2019/10
• Turning features in people with Parkinson’s disease, spinocerebellar ataxia, and healthy control subjects  [Not invited]

  Shah VV, Hasegawa N

  Neuroscience 2019  2019/10
• Role of ventricle volume in the association between cognitive status and mobility metrics in Parkinson’s disorders: A mediation analysis  [Not invited]

  Ragothamani A, Hasegawa N

  Neuroscience 2019  2019/10
• Functional Limits of Stability and Standing Balance in People with and without Freezing of Gait  [Not invited]

  Hasegawa N

  2019 International Parkinson and Movement Disorder Society Congress  2019/09
• Effects of Cognitively Challenging Agility Exercise Program on Clinical and Objective Measures in People with Parkinson’s Disease  [Not invited]

  Carlson-Kuhta P, Hasegawa N

  2019 International Parkinson and Movement Disorder Society Congress  2019/09
• [Lecture] Parkinson’s Foundation Physical Therapy Faculty Program  [Invited]

  Hasegawa N

  Oregon Health & Science University  2019/08
• Feature Selection of Mobility Metrics of Balance Dysfunction in Parkinson’s Disease  [Not invited]

  Hasegawa N

  2019 ISPGR World Congress  2019/07
• Effects of a 6-week cognitively challenging agility exercise program in people with Parkinson's disease  [Not invited]

  Horak FB, Hasegawa N

  2019 ISPGR World Congress  2019/06
• Feature Selection of Objective Metrics of Balance Dysfunction in Parkinson’s Disease  [Not invited]

  Hasegawa N

  OHSU Research Week 2019  2019/05
• [English] 動的バランスにおける感覚フィードバック練習の学習効果の違い  [Invited]

  長谷川 直哉

  第3回北大・部局横断シンポジウム 研究ネットワーク促進プログラム  2018/01
• Adaptation effects of postural control during standing on a tilting board in patients with Parkinson’s disease  [Not invited]

  Hasegawa N

  The Third FHS International Conference  2017/07
• Influences of visual field loss for postural stability during quiet standing in healthy young adults  [Not invited]

  Taneda K, Hasegawa N

  The Third FHS International Conference  2017/07
• 傾斜台上立位保持がパーキンソン病患者の安定性限界と歩行に与える即時効果  [Not invited]

  長谷川 直哉

  第52回日本理学療法学術大会  2017/05
• Different learning effects of dynamic postural control by visual or auditory feedback training  [Not invited]

  Hasegawa N

  Neuroscience 2016  2016/11
• Cortical processes to predict timing gait initiation through visual information  [Not invited]

  Takeda K, Hasegawa N

  Neuroscience 2016  2016/11
• Effects of visual feedback training using center of gravity along with center of pressure for static postural balance  [Not invited]

  Mani H, Hasegawa N

  Neuroscience 2016  2016/11
• 周期的な動作課題における視覚と聴覚フィードバック練習の学習効果の違い  [Not invited]

  長谷川 直哉

  日本健康行動科学会第15回学術大会  2016/09
• ［講師］基礎研究体験フォーラム  [Invited]

  長谷川 直哉

  日本理学療法士協会  2015/03
• Different effects of motor learning between visual and auditory feedback exercises in dynamic postural balance  [Not invited]

  Hasegawa N

  The 1st Asia - Pacific Conference on Coaching Science  2014/07
• 感覚フィードバックの違いが動的バランスの学習効果に与える影響  [Not invited]

  長谷川 直哉

  第49回日本理学療法学術大会  2014/05
• Learning effects of dynamic postural balance by visual or auditory feedback exercise  [Not invited]

  Hasegawa N

  The 67th Congress of the Taiwan Physical Therapy Association  2014/03
• 感覚フィードバックの違いが動的バランスの運動学習に与える影響について  [Not invited]

  長谷川 直哉

  日本健康行動科学会第12回学術大会  2013/09

MISC

• 断続的なフィードバック練習に用いる感覚の違いが姿勢バランス課題の運動学習に与える影響について

  長谷川 直哉, Martina Mancini, Laurie King, Fay Horak, 浅賀 忠義  理学療法学  47-  (Suppl.1)  187  -187  2021/03  [Refereed]
  
• Role of ventricle volume in the association between cognitive status and mobility metrics in Parkinson’s disorders: A mediation analysis

  Ragothamani A, Hasegawa N  Neuroscience 2019  2019/10  [Refereed][Not invited]
  
• Turning features in people with Parkinson’s disease, spinocerebellar ataxia, and healthy control subjects

  Shah VV, Hasegawa N  Neuroscience 2019  2019/10  [Refereed][Not invited]
  
• Multiple domains of postural control in Parkinson’s disease; feature selection of mobility measures

  King LA, Hasegawa N  Neuroscience 2019  2019/10  [Refereed][Not invited]
  
• Effects of an agility exercise program with cognitive challenges on objective measures of gait and balance in people with Parkinson’s disease

  Carlson-Kuhta P, Hasegawa N  Neuroscience 2019  2019/10  [Refereed][Not invited]
  
• Effects of Cognitively Challenging Agility Exercise Program on Clinical and Objective Measures in People with Parkinson’s Disease

  Carlson-Kuhta P, Hasegawa N  2019 International Parkinson and Movement Disorder Society Congress  2019/09  [Refereed][Not invited]
  
• Effects of a 6-week cognitively challenging agility exercise program in people with Parkinson's disease

  Horak FB, Hasegawa N  2019 ISPGR World Congress  2019/06  [Not refereed][Not invited]
  
• 視覚および聴覚のフィードバック練習による動的バランスの学習効果に関する研究

  長谷川 直哉  北海道大学 大学院保健科学院  2018/03  [Refereed][Not invited]
  
• パーキンソン病患者に対する傾斜台立位の効果について

  船水 風花, 佐藤 祐樹, 長谷川 直哉, 浅賀 忠義  Health and Behavior Sciences  16-  (1)  35  -35  2017/09
• 立位姿勢反応と安定性限界が改善したパーキンソン病患者の一症例 足圧中心随伴型床面移動刺激装置を用いた練習効果

  武田 賢太, 花木 里穂, 長谷川 直哉, 萬井 太規, 菅田 葉月, 浅賀 忠義  Health and Behavior Sciences  16-  (1)  36  -36  2017/09
• 周辺視野狭窄が姿勢安定性に及ぼす影響について

  種田 健二, 田中 晨太郎, 武田 賢太, 長谷川 直哉, 小玉 祐也, 萬井 太規, 浅賀 忠義  Health and Behavior Sciences  16-  (1)  38  -38  2017/09
• Influences of visual field loss for postural stability during quiet standing in healthy young adults

  Taneda K, Hasegawa N  The Third FHS International Conference  2017/07  [Not refereed][Not invited]
  
• バランスボード上の姿勢戦略の順応効果

  萬井 太規, 長谷川 直哉, 武田 賢太, 佐藤 佑樹, 田中 晨太郎, 呉 瑕, 前島 洋, 浅賀 忠義  理学療法学  44-  (Suppl.2)  P  -1  2017/04  [Not refereed][Not invited]
  
• 傾斜台上立位保持がパーキンソン病患者の安定性限界と歩行に与える即時効果

  長谷川 直哉, 佐藤 祐樹, 武田 賢太, 大橋 哲朗, 田中 晨太郎, 丸谷 孝史, 加藤 新司, 中山 恭秀, 萬井 太規, 浅賀 忠義  理学療法学  44-  (Suppl.2)  P  -1  2017/04  [Not refereed][Not invited]
  
• 反復後方ステップ練習による非予測的外乱時の即時効果

  田中 晨太郎, 長谷川 直哉, 武田 賢太, 大橋 哲朗, 佐藤 祐樹, 呉 瑕, 丸谷 孝史, 金 雪梅, 萬井 太規, 前島 洋, 浅賀 忠義  理学療法学  44-  (Suppl.2)  P  -2  2017/04  [Not refereed][Not invited]
  
• Effects of visual feedback training using center of gravity along with center of pressure for static postural balance

  Mani H, Hasegawa N  Neuroscience 2016  2016/11  [Not refereed][Not invited]
  
• Cortical processes to predict timing gait initiation through visual information

  Takeda K, Hasegawa N  Neuroscience 2016  2016/11  [Not refereed][Not invited]
  
• クラシックバレエ経験者と非経験者における立位姿勢制御の比較

  伊吹 愛梨, 長谷川 直哉, 武田 賢太, 石川 啓太, 佐久間 萌, 佐藤 祐樹, 田中 晨太郎, 萬井 太規, 前島 洋, 浦賀 忠義  理学療法学  43-  (Suppl.2)  P  -1  2016/10
• パーキンソン病患者に対するトレッドミル後進歩行の効果について 3軸加速度センサー内臓携帯歩行計による検討

  野村 恭平, 長谷川 直哉, 成田 雅  理学療法学  43-  (Suppl.2)  O  -2  2016/10
• バランスボード上における姿勢制御の順応効果について

  萬井 太規, 長谷川 直哉, 武田 賢太, 佐久間 萌, 伊吹 愛梨, 石川 啓太, Hsiao Shi-Fen, 浅賀 忠義  理学療法学  43-  (Suppl.2)  O  -1  2016/10  [Not refereed][Not invited]
  
• 口頭指示の違いが姿勢安定性と姿勢戦略に与える影響

  佐久間 萌, 長谷川 直哉, 武田 賢太, 伊吹 愛梨, 石川 啓太, 田中 晨太郎, 佐藤 祐樹, 呉 瑕, 萬井 太規, 前島 洋, 浅賀 忠義  理学療法学  43-  (Suppl.2)  P  -3  2016/10  [Not refereed][Not invited]
  
• 予測的な反復後方ステップ練習による非予測的外乱時の即時効果

  田中 晨太郎, 長谷川 直哉, 武田 賢太, 呉 瑕, 浅賀 忠義  Health and Behavior Sciences  15-  (1)  32  -32  2016/08
• 周期的な動作課題における視覚と聴覚フィードバック練習の学習効果の違い

  長谷川 直哉, 武田 賢太, 田中 辰太郎, 呉 瑕, 萬井 太規, 浅賀 忠義  Health and Behavior Sciences  15-  (1)  40  -40  2016/08
• 足圧中心と体重心の同時視覚フィードバック練習による静的立位バランスの効果

  呉 瑕, 武田 健太, 長谷川 直哉, 田中 晨太郎, 浅賀 忠義  Health and Behavior Sciences  15-  (1)  41  -41  2016/08
• 視覚情報を用いたタイミング予測下における歩行開始時の皮質処理

  武田 賢太, 長谷川 直哉, 田中 辰太郎, 呉 瑕, 浅賀 忠義  Health and Behavior Sciences  15-  (1)  43  -43  2016/08
• バランスボード上における姿勢制御の順応効果について

  萬井 太規, 長谷川 直哉, 武田 賢太, 佐久間 萌, 伊吹 愛梨, 石川 啓太, Hsiao Shi-Fen, 浅賀 忠義  日本基礎理学療法学雑誌  20-  (1)  67  -67  2016/08  [Not refereed][Not invited]
  
• クラシックバレエ経験者と非経験者における立位姿勢制御の比較

  伊吹 愛梨, 長谷川 直哉, 武田 賢太, 石川 啓太, 佐久間 萌, 佐藤 祐樹, 田中 晨太郎, 萬井 太規, 前島 洋, 浅賀 忠義  日本基礎理学療法学雑誌  20-  (1)  241  -241  2016/08  [Not refereed][Not invited]
  
• 口頭指示の違いが姿勢安定性と姿勢戦略に与える影響

  佐久間 萌, 長谷川 直哉, 武田 賢太, 伊吹 愛梨, 石川 啓太, 田中 晨太郎, 佐藤 祐樹, 呉 瑕, 萬井 太規, 前島 洋, 浅賀 忠義  日本基礎理学療法学雑誌  20-  (1)  307  -307  2016/08  [Not refereed][Not invited]
  
• 口頭指示の違いが姿勢バランスに与える影響 姿勢安定性と周波数特性に着目して

  佐久間 萌, 萬井 太規, 長谷川 直哉, 武田 賢太, 伊吹 愛梨, 石川 啓太, 田中 晨太郎, 佐藤 祐樹, 呉 瑕, 前島 洋, 浅賀 忠義  日本基礎理学療法学雑誌  19-  (1)  64  -64  2016/01  [Not refereed][Not invited]
  
• ターゲットの消失タイミングが歩行開始におけるタイミング予測に与える影響

  武田 賢太, 長谷川 直哉, 伊吹 愛梨, 萬井 太規, 浅賀 忠義  Health and Behavior Sciences  14-  (1)  44  -44  2015/09
• 優れた静的バランス能力のメカニズム解明に関する研究

  伊吹 愛梨, 萬井 太規, 長谷川 直哉, 武田 賢太, 浅賀 忠義  Health and Behavior Sciences  14-  (1)  52  -52  2015/09
• クロスステップ練習が片脚立位動作時の姿勢安定性を向上させるか?

  萬井 太規, 武田 賢太, 伊吹 愛梨, 長谷川 直哉, 浅賀 忠義  Health and Behavior Sciences  14-  (1)  52  -52  2015/09
• Effects of timing of vanishing target on anticipatory timing during gait initiation

  Takeda K, Hasegawa N  International Symposium on Modern Health Sciences  2015/02  [Not refereed][Not invited]
  
• 視覚消失タイミングが歩行開始のタイミング予測に与える影響

  武田 賢太, 萬井 太規, 諏訪原 司, 長谷川 直哉, 戸塚 満久, 津田 章代, 大橋 哲朗, 趙 静, 石川 啓太, 伊吹 愛梨, 佐久間 萌, 前島 洋, 浅賀 忠義  日本基礎理学療法学雑誌  18-  (1)  65  -65  2014/11  [Not refereed][Not invited]
  
• 口頭指示の違いが前方水平外乱における後方ステップに与える影響

  諏訪原 司, 武田 賢太, 大橋 哲朗, 萬井 太規, 長谷川 直哉, 戸塚 満久, 津田 章代, 趙 静, 石川 啓太, 伊吹 愛梨, 佐久間 萌, 前島 洋, 浅賀 忠義  日本基礎理学療法学雑誌  18-  (1)  66  -66  2014/11  [Not refereed][Not invited]
  
• 着座動作の足関節可動域制限による姿勢と座面圧への影響について

  大橋 哲朗, 萬井 太規, 諏訪原 司, 佐久間 萌, 長谷川 直哉, 戸塚 満久, 津田 章代, 武田 賢太, 伊吹 愛梨, 石川 啓太, 趙 静, 前島 洋, 浅賀 忠義  日本基礎理学療法学雑誌  18-  (1)  66  -66  2014/11  [Not refereed][Not invited]
  
• The relationship between center of mass and center of pressure in the limits of stability

  Totsuka M, Hasegawa N  The 1st Asia - Pacific Conference on Coaching Science  2014/07  [Not refereed][Not invited]
  
• Difference of the relative distances from center of pressure to center of mass between the young and elderly people during one-leg standing

  Mani H, Hasegawa N  The 1st Asia - Pacific Conference on Coaching Science  2014/07  [Not refereed][Not invited]
  
• 加齢に伴う片脚立位動作の不安定性要因について 体重心と足圧中心との位置関係に着目して

  萬井 太規, 長谷川 直哉, 戸塚 満久, 津田 章代, 武田 賢太, 大橋 哲朗, 伊藤 久美子, 諏訪原 司, 趙 静, Hsiao Shi-Fen, 浅賀 忠義  理学療法学  41-  (大会特別号2)  1146  -1146  2014/05  [Not refereed][Not invited]
   

  【目的】片脚立位は，高齢者の転倒予防プログラムの一つとして全国的に普及している（阪本，2013）。この動作は，下肢挙上直前に足圧中心（COP）が遊脚側へ偏位することによって体重心（COM）を支持脚側へ加速させる相（加速相），COPが支持脚側へCOMよりも先行することによってCOMを減速させる相（減速相）およびCOMを支持脚内で保持する相（保持相）の3相に区分できる。既往研究では，加齢に伴い片脚立位時間の減少（Bohannon, 1984）やCOPの動揺の増加（Gilagys, 2007）などが報告されている。さらに，筆者らは高齢者においては極端に立位時間の短い施行（失敗）が観察され，片脚立位時におけるCOMの位置および速度の再現性が若年者と比べて有意に低下することを報告した（第12回日本行動科学会）。しかしながら，片脚立位動作をCOMとCOPの位置関係に着目して，加齢による不安定性の要因について調べた研究は筆者らが知る限り見あたらない。COMとCOPは離れるほど身体に大きなモーメントが発生し，不安定性の要因となる。従って，本研究の目的は片脚立位動作の加齢による影響についてと高齢者の失敗要因について，各相別にCOMとCOPの位置関係に着目して明らかにすることだった。【方法】対象は，健常若年者10名（22.4±1.2歳）と健常高齢者10名（68.1±2.4歳）だった。前額面のCOMとCOPを算出するために，三次元動作解析システムと床反力計を用いた。被験者は2枚の床反力計上にそれぞれ足を乗せて安静立位となり，任意のタイミングで片足を拳上し，目標点を注視してできるだけ長く保持するように指示された。保持時間は最大30秒間とし，一人計20回施行した。反射マーカーから求められた下肢挙上時点（T₀）直前のCOPが遊脚方向へ偏位する相を加速相，COPがCOMを追い越した時点（T₁）からCOMの速度が0になった時点（T₂）までを減速相，T₂以降を保持相とした。加速相におけるCOP偏位の最大値（COP_peak），減速相におけるCOMとCOP間の最大距離（減速相D_peak）および二乗平均平方根（減速相D_RMS），保持相におけるCOMとCOP間の二乗平均平方根（保持相D_RMS）を算出した。全ての変数を各被験者の両上前腸骨棘間の距離で正規化した。さらに，高齢者毎に片脚立位時間から失敗施行（全施行の平均値から標準偏差値を引いた秒数以下）とそれ以外の成功施行とに区別した。両群（高齢者，若年者）の比較には対応のないt検定を，各高齢者内の施行間（失敗施行，成功施行）の比較には対応のあるt検定を用いた。高齢者の片脚立位時間と各変数との相関はPearsonの相関係数を用いた。危険率は5％とした。【説明と同意】被験者には研究目的および手順について十分に説明し書面にて同意を得た。本研究は所属機関の倫理委員会の承認を得ている。【結果】安静立位時におけるCOMとCOPの初期位置は両群および施行間で有意差はなかった。若年者は全施行で30秒以上保持可能だった。一方，高齢者は全施行の平均時間が16.4±8.5秒，成功施行の平均時間が20.3±9.5秒，および失敗施行の平均時間が6.8±4.0秒だった。両群を比較した結果，加速相のCOP_peak，および減速相D_peakには有意差がなかった。高齢者は若年者よりも減速相D_RMSおよび保持相D_RMSがともに有意に大きかった（P＜0.05）。高齢者は，片脚立位時間と保持相D_RMS間に負の相関の傾向があり（r=-0.57，P=0.088），減速相D_RMSと保持相D_RMS間に有意な相関（r=0.71，P＜0.05）が認められた。さらに，施行間の比較では，加速相のCOP_peakに有意差は認められなかったが，減速相D_peak，減速相D_RMSおよび保持相D_RMSは失敗施行の方が有意に大きかった（P＜0.05）。【考察】高齢者は若年者よりも減速相D_RMSおよび保持相D_RMSが有意に大きく，尚且つ，高齢者では両変数間に有意な相関がみられたことから，高齢者はCOMを減速させるために身体に大きなモーメントが発生し，そのことがその後の身体の動揺にも影響を与えていると考えられる。さらに，高齢者の失敗施行ではこれらの変数に加えて減速相D_peakが有意に大きかったことから，COPによる過剰なブレーキングによってCOMが立脚肢内から早期に遊脚側へ逸脱してしまうと考えられる。加齢によって減速相に要求されるフィードフォワード制御とフィードバック制御の合目的な統合能力の低下が示唆される（Rachel, 2012）。【理学療法学研究としての意義】片脚立位動作では，加齢に伴い減速相における姿勢制御が重要であることが初めて明らかとなった。本研究の成果は，片脚立位動作の有効な指導方法および運動療法を提案するための科学的根拠となる。
• 感覚フィードバックの違いが動的バランスの学習効果に与える影響

  長谷川 直哉, 萬井 太規, 戸塚 満久, 津田 章代, 伊藤 久美子, 大橋 哲朗, 諏訪原 司, 武田 賢太, 趙 静, Hsiao Shih-Fen, 笠原 敏史, 浅賀 忠義  理学療法学  41-  (大会特別号2)  0296  -0296  2014/05  [Refereed][Not invited]
   

  【はじめに，目的】立位バランスの改善を目的とする練習方法として感覚フィードバックを用いた練習が一般的に行われている。感覚フィードバックには主として視覚・聴覚・体性感覚が使用されており，その効果は多くの先行研究で示されている。しかし，その効果は姿勢動揺を減少させるための静的バランスを課題としており，随意的に体重心を移動させるための動的バランスについての報告は極めて少ない。加えて，用いられている感覚は視覚が多く，聴覚など他の感覚フィードバックによる学習効果と比較検討した立位バランスに関する研究は筆者らが知る限り見当たらない。従って，本研究はフィードバック練習に用いる感覚の違いが動的バランスの学習効果に与える影響について明らかにすることを目的とした。【方法】被験者は，健常若年者18名（平均年齢22.3±1.9歳，平均身長165.8±7.5cm，平均体重56.4±7.9kg）であり，無作為に聴覚刺激をフィードバックに用いた9名（聴覚群）と視覚刺激をフィードバックに用いた9名（視覚群）に割り当てられた。被験者には，床反力計上に裸足で立ち，前方に設置したモニター画面上に表示された前後方向に移動するターゲットに自身の足圧中心（COP）を一致させるように指示した（動的バランス課題）。ターゲットは被験者のCOP最大移動距離の前方80%から後方70%を周波数0.23Hzで移動するようにLabVIEWソフトウェアを用いて作成した。練習課題ではターゲットの他にCOP最大移動距離の前方70～80%，後方60～70%の範囲に被験者のCOPが位置したときに各群に合わせたフィードバックを与えた（聴覚群：スピーカーからの音，視覚群：モニター画面上に赤い点）。課題は1施行30秒とし，1日目には練習前と練習後に動的バランス課題を5施行ずつと練習課題を20施行で合わせて30施行を行い，1日介入のない日を設けて，3日目に動的バランス課題5施行を行った。また，動作開始時の影響を取り除くために，1施行の7周期から最初の1周期を除外した6周期を解析対象とした。動作の正確性の指標として，床反力計から算出された被験者のCOPとターゲットとの間の距離の二乗平均平方根（RMS）を使用した。フィードバック練習の適応および学習効果について調べるために，練習前・練習後・3日目の3群間比較には一元配置分散分析および多重比較を行った。また，両群間（視覚，聴覚）の比較をするために，練習前のRMS値，練習前と練習後のRMS値の差および練習後と3日目のRMS値の差による変化量を算出し，対応のないt検定を行った。検定の有意水準は5%未満とした。【倫理的配慮，説明と同意】被験者には事前に口頭と書面で本研究の目的や実験手順，考えられる危険性などを十分に説明し，書面にて同意を得た。本研究は，当大学院倫理委員会の承認を得て行った。【結果】課題間での比較については，聴覚群は練習前と比較して練習後および3日目で有意な低下を示した（p＜0.01）。一方，視覚群では練習前と比較して練習後に有意な低下を示したが（p＜0.05），3日目は有意差がみられなかった。群間の比較では，練習前のRMS値に有意差はみられなかった。変化量の比較では，練習前後で両群間に有意差はみられなかったが，練習後から3日目を引いた値では視覚群（-4.19±3.62）は聴覚群（0.78±2.38）と比較して有意に小さい値を示した（p＜0.01）。【考察】練習前の群間比較でRMS値に有意差がみられず，練習前後では両群ともに有意な低下が示された。さらに，その変化量には有意差がみられなかった。従って，動的バランスにおいて聴覚および視覚のフィードバック練習によって同程度の適応効果が示されたと考えられる。しかしながら，聴覚群では3日目においてもその効果の保続が示されたが，視覚群では一日あけることによって練習前の正確性に戻り，変化量の群間比較においても有意差が示された。従って，聴覚フィードバック練習によって学習効果が示されたが，視覚フィードバック練習では学習されにくいことが示唆される。Ronsseらは，両手の協調運動を用いて視覚フィードバック練習では視覚刺激に頼りがちになるが，聴覚フィードバックを用いた場合は刺激に頼らない神経回路が構築されやすいことを明らかにした。よって，随意運動を伴う動的バランス練習においても聴覚刺激の方が運動学習には有効であると考えられる。【理学療法学研究としての意義】立位バランスにおいて，異なる感覚フィードバックによる学習効果の違いを初めて明らかにした。本研究成果は，視覚に頼らない有効な感覚フィードバック練習を提案するための科学的根拠となる。
• 感覚フィードバックの違いが動的バランスの運動学習に与える影響について

  長谷川 直哉, 萬井 太規, Hsiao Shih-Fen, 戸塚 満久, 津田 章代, 伊藤 久美子, 大橋 哲朗, 諏訪原 司, 武田 賢太, 趙 静, 浅賀 忠義  Health and Behavior Sciences  12-  (1)  51  -51  2013/09
• 片脚立位パフォーマンスの再現性における加齢の影響について

  萬井 太規, Hsiao Shih-Fen, 長谷川 直哉, 戸塚 満久, 津田 章代, 武田 賢太, 大橋 哲朗, 諏訪原 司, 伊藤 久美子, 趙 静, 浅賀 忠義  Health and Behavior Sciences  12-  (1)  56  -56  2013/09
• Characteristics of Stability Limits and Pressure Distributions during Reaching Movements in Patients with Stroke

  Tsuda A, Hasegawa N  The 6th Asia-Western Pacific Regional Congress of the World Confederation for Physical Therapy & The 12th International Congress of Asian Confederation for Physical Therapy (WCPT-AWP & ACPT Congress 2013)  2013/09  [Not refereed][Not invited]
  
• Adaptation of postural strategy with a mobile base of support

  Mani H, Hasegawa N  The 6th Asia-Western Pacific Regional Congress of the World Confederation for Physical Therapy & The 12th International Congress of Asian Confederation for Physical Therapy (WCPT-AWP & ACPT Congress 2013)  2013/09  [Not refereed][Not invited]
  

Awards & Honors

• 2019/12 International Parkinson and Movement Disorder Society 2019 Travel Grant Award
   Functional Limits of Stability and Standing Balance in People with and without Freezing of Gait 

  受賞者: Naoya Hasegawa
• 2013/09 日本健康行動科学会第12回学術大会 大会長優秀発表賞
   感覚フィードバックの違いが動的バランスの運動学習に与える影響について 

  受賞者: 長谷川 直哉

Research Grants & Projects

• Development of novel effective interventions using transcutaneous vagus nerve stimulation for postural instability in Parkinson's disease

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2023/04 -2027/03 

  Author : 岡田 洋平, 形岡 博史, 西 祐樹, 長谷川 直哉
• The effects by difference in difficulties of cognitive loads in dual-task training on performance of stepping task with cognitive loads

  公益財団法人伊藤医薬学術交流財団：伊藤財団 2023 年度研究助成金(A.交流助成)

  Date (from‐to) : 2023/08 -2024/03
• Impacts of a loss of binocular or motion parallax on static postural stability

  公益財団法人伊藤医薬学術交流財団：伊藤財団 2023 年度研究助成金(A.交流助成)

  Date (from‐to) : 2023/08 -2024/03
• Developments of Sensory Feedback Training Methods for Freezing of Gait in People with Parkinson's Disease

  Japan Society for the Promotion of Science：Grant-in-Aid for Scientific Research

  Date (from‐to) : 2020/04 -2024/03 

  Author : Naoya Hasegawa

   

  本研究の目的は，パーキンソン病患者の主要症状であるすくみ足や姿勢制御障害の改善を目的として，運動学習に着目した新たな感覚フィードバック練習を考案することだった。対象となるすくみ足のあるパーキンソン病患者について姿勢バランス能力の検証を行い，健常高齢者およびすくみ足のないパーキンソン病患者と比較して安定性限界と呼ばれる重心の最大移動範囲が狭小化している一方で，立位時の動揺範囲など静止立位における姿勢制御能力はすくみ足のないパーキンソン病患者と比較して大きな差がないことを報告した。従って，パーキンソン病患者におけるすくみ足に最大重心移動範囲の狭小化が関係している可能性が示唆された。本研究の成果は，Gait ＆ Postureに掲載された。 さらに，上述した安定性限界のうち前方への安定性限界の狭小化に対して，母趾だけでなく，第二趾が大きな影響を与えることを健常若年者を対象とした研究によって示した。本研究の成果は，Health and Behavior Sciencesに掲載された。 また，健常若年者を対象に外乱に対する代償的なステッピングの練習効果を比較検証した。その結果，外乱が生じる方向を事前に教示したステッピング練習でも方向を事前に教示しないステッピング練習と同程度の練習効果を外乱の方向およびタイミングを教示しない外乱刺激に対して示すことを報告した。従って，より安全性の高い外乱の方向を教示した練習方法でもステッピング練習の効果が得られることが示唆され，姿勢制御能力に障害があるパーキンソン病患者に対する応用の可能性が示された。本研究の成果はFrontiers in Human Neuroscienceに掲載された。
• Developing an interdisciplinary component to research-informed international education of the future geriatric allied health worker.

  北海道大学 - メルボルン大学合同研究ワークショップファンド

  Date (from‐to) : 2022/07 -2023/03 

  Author : Sawamura D, Coleman M, Hasegawa N
• Learning effects of postural control by auditory biofeedback

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

  Date (from‐to) : 2018/04 -2023/03 

  Author : 浅賀 忠義, 長谷川 直哉, 武田 賢太

   

  断続的な聴覚および視覚フィードバック (FB)の動的バランスにおける学習効果について比較することを目的に実験を実施した．対象は健常若年者22名で，ランダムに2群（聴覚FB群，視覚FB群）に分けられた．随意的なBody sway課題を実施し，その学習効果について比較した．足圧中心位置とターゲットとのコヒーレンスの結果から，聴覚FB群の方が視覚FB群と比べて学習効果が高いことが示された．この結果は，前回我々が報告した連続的な感覚FBを用いた結果と同様であった．本研究成果は，Society for Neuroscience 2019 (USA)で発表予定である． パーキンソン病 (PD) 患者を対象にFBの練習効果の確認指標を決定することを目的に研究を行った．対象は，PD患者142名（年齢：68±8歳）と健常高齢者76名（年齢：68±8歳）だった．静的および動的バランスの課題を実施した．ランダムフォレストアルゴリズムを用いて57の指標の中から最も感度の高い4つの指標を抽出した．本研究成果は，International Society of Posture & Gait research 2019 (UK)で発表予定である， PD患者においてすくみ足 (FoG) の有無が安定性限界や姿勢バランスに影響するか否かについて調べることを目的に研究を行った．対象は，FoG が観られるPD患者64名（PD+FoG; 年齢：68±8歳），FoG が観られないPD患者80名（PD-FoG; 年齢：69±8歳）および健常高齢者79名（HC; 年齢：68±8歳）だった．安定性限界において，PD+FoGはPD-FoG とHCよりも有意に小さいことが示された．一方，安静立位時における姿勢動揺には有意差が認められなかった．本研究成果は，Parkinson and Movement Disorder Society 2019 (France)で発表予定である．

Educational Activities

Teaching Experience

Committee Membership

• 2022/10 - Today   Sensors   Guest Editor
• 2021/06 - Today   Frontiers in Rehabilitation Sciences   Topic Editor
• 2020/11 - Today   Frontiers in Rehabilitation Sciences   Review Editor
• 2021/02 -2023/02   Frontiers in Human Neuroscience   Topic Editor

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Academic Contribution

• 理学療法ガイドライン第2版

  Date (from-to) :2018/10/01-2021/10/25

  Role: Review

  Type: Academic research

  Organizer, responsible person: 公益社団法人日本理学療法士協会