Researcher Database

Naoki Miyamoto
Faculty of Engineering Applied Quantum Science and Engineering Quantum Engineering for Life Science and Medicine
Associate Professor

Researcher Profile and Settings

Affiliation

  • Faculty of Engineering Applied Quantum Science and Engineering Quantum Engineering for Life Science and Medicine

Job Title

  • Associate Professor

Research funding number

  • 00552879

J-Global ID

Research Interests

  • medical physics   放射線治療   Image Guided Radiation Therapy   4D Radiation Therapy   

Research Areas

  • Life sciences / Radiology

Academic & Professional Experience

  • 2014/04 - Today Hokkaido University Hospital Department of Radiation Medicine Assistant Professor
  • 2008/04 - 2013/03 Graduate School of Medicine Department of Medical Physics Assistant Professor
  • 2006/04 - 2008/03 Graduate School of Engineering Quantum Beam System Engineering Postdoctoral Fellow

Education

  • 2003/04 - 2006/03  Hokkaido University
  • 2001/04 - 2003/03  Hokkaido University  Graduate School of Engineering  Department of Quantum Energy Engineering
  • 1997/04 - 2001/03  Hokkaido University  Faculty of Engineering  Nuclear Engineering

Association Memberships

  • JAPANESE SOCIETY FOR RADIATION ONCOLOGY   THE JAPANESE SOCIETY FOR NON-DESTRUCTIVE INSPECTION   THE JAPAN SOCIETY OF APPLIED PHYSICS   JAPAN SOCIETY OF MEDICAL PHYSICS   ATOMIC ENERGY SOCIETY OF JAPAN   

Research Activities

Published Papers

  • Satoshi Tomioka, Shusuke Nishiyama, Naoki Miyamoto, Daichi Kando, Samia Heshmat
    APPLIED OPTICS 56 (24) 6755 - 6764 1559-128X 2017/08 [Refereed][Not invited]
     
    Interferometric tomography can reconstruct 3D refractive-index distributions through phase-shift measurements for different beam angles. To reconstruct a complex refractive-index distribution, many projections along different directions are required. For the purpose of increasing the number of the projections, we earlier proposed a beam-angle-controllable interferometer with mechanical stages; however, the quality of reconstructed distribution by conventional algorithms was poor because the background fringes cannot be precisely controlled. To improve the quality, we propose a weighted reconstruction algorithm that can consider projection errors. We demonstrate the validity of the weighted reconstruction through simulations and a reconstruction from experimental data for three candle flames. (C) 2017 Optical Society of America
  • Yusuke Fujii, Taeko Matsuura, Seishin Takao, Yuka Matsuzaki, Takaaki Fujii, Naoki Miyamoto, Kikuo Umegaki, Kentaro Nishioka, Shinichi Shimizu, Hiroki Shirato
    JOURNAL OF RADIATION RESEARCH 58 (4) 591 - 597 0449-3060 2017/07 [Refereed][Not invited]
     
    For proton spot scanning, use of a real-time-image gating technique incorporating an implanted marker and dual fluoroscopy facilitates mitigation of the dose distribution deterioration caused by interplay effects. This study explored the advantages of using a real-time-image gating technique, with a focus on prostate cancer. Two patient-positioning methods using fiducial markers were compared: (i) patient positioning only before beam delivery, and (ii) patient positioning both before and during beam delivery using a real-time-gating technique. For each scenario, dose distributions were simulated using the CT images of nine prostate cancer patients. Treatment plans were generated using a single-field proton beam with 3-mm and 6-mm lateral margins. During beam delivery, the prostate was assumed to move by 5 mm in four directions that were perpendicular to the beam direction at one of three separate timings (i.e. after the completion of the first, second and third quartiles of the total delivery of spot irradiation). Using a 3-mm margin and second quartile motion timing, the averaged values for Delta D-99, Delta D-95, Delta D-5 and D5-95 were 5.1%, 3.3%, 3.6% and 9.0%, respectively, for Scenario (i) and 2.1%, 1.5%, 0.5% and 4.1%, respectively, for Scenario (ii). The margin expansion from 3 mm to 6 mm reduced the size of Delta D-99, Delta D-95, Delta D-5 and D5-95 only with Scenario (i). These results indicate that patient positioning during beam delivery is an effective way to obtain better target coverage and uniformity while reducing the target margin when the prostate moves during irradiation.
  • Analysis of inter- and intra fractional partial bladder wall movement using implanted fiducial markers
    Kentaro Nishioka, Shinichi Shimizu, Nobuo Shinohara, Yoichi M. Ito, Takashige Abe, Satoru Maruyama, Norio Katoh, Rumiko Kinoshita, Takayuki Hashimoto, Naoki Miyamoto, Rikiya Onimaru, Hiroki Shirato
    Radiation Oncology 12 (1) 44  2017/03/01 [Refereed][Not invited]
  • Takahiro Kanehira, Taeko Matsuura, Seishin Takao, Yuka Matsuzaki, Yusuke Fujii, Takaaki Fujii, Yoichi M. Ito, Naoki Miyamoto, Tetsuya Inoue, Norio Katoh, Shinichi Shimizu, Kikuo Umegaki, Hiroki Shirato
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 97 (1) 173 - 181 0360-3016 2017/01 [Refereed][Not invited]
     
    Purpose: To investigate the effectiveness of real-time-image gated proton beam therapy for lung tumors and to establish a suitable size for the gating window (GW). Methods and Materials: A proton beam gated by a fiducial marker entering a preassigned GW (as monitored by 2 fluoroscopy units) was used with 7 lung cancer patients. Seven treatment plans were generated: real-time-image gated proton beam therapy with GW sizes of +/- 1, 2, 3, 4, 5, and 8 mm and free-breathing proton therapy. The prescribed dose was 70 Gy (relative biological effectiveness)/10 fractions to 99% of the target. Each of the 3-dimensional marker positions in the time series was associated with the appropriate 4-dimensional computed tomography phase. The 4-dimensional dose calculations were performed. The dose distribution in each respiratory phase was deformed into the end-exhale computed tomography image. The D99 and D5 to D95 of the clinical target volume scaled by the prescribed dose with criteria of D99 > 95% and D5 to D95 < 5%, V20 for the normal lung, and treatment times were evaluated. Results: Gating windows <= +/- 2 mm fulfilled the CTV criteria for all patients (whereas the criteria were not always met for GWs >= +/- 3 mm) and gave an average reduction in V20 of more than 17.2% relative to free-breathing proton therapy (whereas GWs >= +/- 4 mm resulted in similar or increased V20). The average (maximum) irradiation times were 384 seconds (818 seconds) for the +/- 1-mm GW, but less than 226 seconds (292 seconds) for the +/- 2-mm GW. The maximum increased considerably at +/- 1-mm GW. Conclusion: Real-time-image gated proton beam therapy with a GW of +/- 2 mm was demonstrated to be suitable, providing good dose distribution without greatly extending treatment time. (C) 2016 Elsevier Inc. All rights reserved.
  • Takahiro Yamada, Naoki Miyamoto, Taeko Matsuura, Seishin Takao, Yusuke Fujii, Yuka Matsuzaki, Hidenori Koyano, Masumi Umezawa, Hideaki Nihongi, Shinichi Shimizu, Hiroki Shirato, Kikuo Umegaki
    PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS 32 (7) 932 - 937 1120-1797 2016/07 [Refereed][Not invited]
     
    Purpose: To find the optimum parameter of a new beam control function installed in a synchrotron-based proton therapy system. Methods: A function enabling multiple gated irradiation in the flat top phase has been installed in a real-time-image gated proton beam therapy (RGPT) system. This function is realized by a waiting timer that monitors the elapsed time from the last gate-off signal in the flat top phase. The gated irradiation efficiency depends on the timer value, T-w. To find the optimum Tw value, gated irradiation efficiency was evaluated for each configurable T-w value. 271 gate signal data sets from 58 patients were used for the simulation. Results: The highest mean efficiency 0.52 was obtained in T-W = 0.2 s. The irradiation efficiency was approximately 21% higher than at T-W = 0 s, which corresponds to ordinary synchrotron operation. The irradiation efficiency was improved in 154 (57%) of the 271 cases. The irradiation efficiency was reduced in 117 cases because the T-W value was insufficient or the function introduced an unutilized wait time for the next gate-on signal in the flat top phase. In the actual treatment of a patient with a hepatic tumor at T-w = 0.2 s, 4.48 GyE irradiation was completed within 250 s. In contrast, the treatment time of ordinary synchrotron operation was estimated to be 420 s. Conclusions: The results suggest that the multiple gated-irradiation function has potential to improve the gated irradiation efficiency and to reduce the treatment time. (C) 2016 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.
  • Toshiyuki Hamada, Kenneth Sutherland, Masayori Ishikawa, Naoki Miyamoto, Sato Honma, Hiroki Shirato, Ken-ichi Honma
    Nature Communications 11705 2016/06/10 [Refereed][Not invited]
  • Keiichi Harada, Norio Katoh, Ryusuke Suzuki, Yoichi M. Ito, Shinichi Shimizu, Rikiya Onimaru, Tetsuya Inoue, Naoki Miyamoto, Hiroki Shirato
    PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS 32 (2) 305 - 311 1120-1797 2016/02 [Refereed][Not invited]
     
    Purpose: We investigated the usefulness of four-dimensional computed tomography (4DCT) performed before stereotactic body radiation therapy (SBRT) in determining the internal margins for peripheral lung tumors. Methods and Materials: The amplitude of the movement of a fiducial marker near a lung tumor measured using the maximum intensity projection (MIP) method in 4DCT imaging was acquired before the SBRT (Amp(CT)) and compared with the mean amplitude of the marker movement during SBRT (Amp(mean)) and with the maximum amplitude of the marker movement during SBRT (Amp(max)) using a real-time tumortracking radiotherapy (RTRT) system with 22 patients. Results: There were no significant differences between the means of the Amp(mean) and the means of the Amp(CT) in all directions (LR, P = 0.45; CC, P = 0.80; AP, P = 0.65). The means of the Amp(max) were significantly larger than the means of the Amp(CT) in all directions (LR, P < 0.01; CC, P = 0.03; AP, P < 0.01). In the lower lobe, the mean difference of the Amp(CT) from the mean of the Amp(max) was 5.7 +/- 8.0 mm, 12.5 +/- 16.7 mm, and 6.8 +/- 8.5 mm in the LR, CC, and AP directions, respectively. Conclusions: Acquiring 4DCT MIP images before the SBRT treatment is useful to establish the mean amplitude for a patient during SBRT but it underestimates the maximum amplitude during actual SBRT. Caution must be paid to determine the margin with the 4DCT especially for tumors at the lower lobe where it is of the potentially greatest benefit. (C) 2016 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd.
  • Taeko Matsuura, Yusuke Fujii, Seishin Takao, Takahiro Yamada, Yuka Matsuzaki, Naoki Miyamoto, Taisuke Takayanagi, Shinichiro Fujitaka, Shinichi Shimizu, Hiroki Shirato, Kikuo Umegaki
    PHYSICS IN MEDICINE AND BIOLOGY 61 (4) 1515 - 1531 0031-9155 2016/02 [Refereed][Not invited]
     
    Treatment of superficial tumors that move with respiration (e.g. lung tumors) using spot-scanning proton therapy (SSPT) is a high-priority research area. The recently developed real-time image-gated proton beam therapy (RGPT) system has proven to be useful for treating moving tumors deep inside the liver. However, when treating superficial tumors, the proton's range is small and so is the sizes of range straggling, making the Bragg-peaks extremely sharp compared to those located in deep-seated tumors. The extreme sharpness of Bragg-peaks is not always beneficial because it necessitates a large number of energy layers to make a spread-out Bragg-peak, resulting in long treatment times, and is vulnerable to motion-induced dose deterioration. We have investigated a method to treat superficial moving tumors in the lung by the development of an applicator compatible with the RGPT system. A mini-ridge filter (MRF) was developed to broaden the pristine Bragg-peak and, accordingly, decrease the number of required energy layers to obtain homogeneous irradiation. The applicator position was designed so that the fiducial marker's trajectory can be monitored by fluoroscopy during proton beam-delivery. The treatment plans for three lung cancer patients were made using the applicator, and four-dimensional (4D) dose calculations for the RGPT were performed using patient respiratory motion data. The effect of the MRF on the dose distributions and treatment time was evaluated. With the MRF, the number of energy layers was decreased to less than half of that needed without it, whereas the target volume coverage values (D99%, D95%, D50%, D2%) changed by less than 1% of the prescribed dose. Almost no dose distortion was observed after the 4D dose calculation, whereas the treatment time decreased by 26%-37%. Therefore, we conclude that the developed applicator compatible with RGPT is useful to solve the issue in the treatment of superficial moving tumors with SSPT.
  • Seishin Takao, Naoki Miyamoto, Taeko Matsuura, Rikiya Onimaru, Norio Katoh, Tetsuya Inoue, Kenneth Lee Sutherland, Ryusuke Suzuki, Hiroki Shirato, Shinichi Shimizu
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 94 (1) 172 - 180 0360-3016 2016/01 [Refereed][Not invited]
     
    Purpose: To investigate the frequency and amplitude of baseline shift or drift (shift/drift) of lung tumors in stereotactic body radiation therapy (SBRT), using a real-time tumor-tracking radiation therapy (RTRT) system. Methods and Materials: Sixty-eight patients with peripheral lung tumors were treated with SBRT using the RTRT system. One of the fiducial markers implanted near the tumor was used for the real-time monitoring of the intrafractional tumor motion every 0.033 seconds by the RTRT system. When baseline shift/drift is determined by the system, the position of the treatment couch is adjusted to compensate for the shift/drift. Therefore, the changes in the couch position correspond to the baseline shift/drift in the tumor motion. The frequency and amount of adjustment to the couch positions in the left-right (LR), cranio-caudal (CC), and antero-posterior (AP) directions have been analyzed for 335 fractions administered to 68 patients. Results: The average change in position of the treatment couch during the treatment time was 0.45 +/- 2.23 mm (mean +/- standard deviation), -1.65 +/- 5.95 mm, and 1.50 +/- 2.54 mm in the LR, CC, and AP directions, respectively. Overall the baseline shift/drift occurs toward the cranial and posterior directions. The incidence of baseline shift/drift exceeding 3 mm was 6.0%, 15.5%, 14.0%, and 42.1% for the LR, CC, AP, and for the square-root of sum of 3 directions, respectively, within 10 minutes of the start of treatment, and 23.0%, 37.6%, 32.5%, and 71.6% within 30 minutes. Conclusions: Real-time monitoring and frequent adjustments of the couch position and/or adding appropriate margins are suggested to be essential to compensate for possible underdosages due to baseline shift/drift in SBRT for lung cancers. (C) 2016 Elsevier Inc. All rights reserved.
  • Dynamic image prediction using principle component and multi-channel singular spectral analysis: a feasibility study
    Ritu Bhusal Chhatkuli, Kazuyuki Demachi, Naoki Miyamoto, Mitsuru Uesaka, Akihiro Haga
    Open Journal of Medical Imaging 5 (3) 133 - 142 2015/09/09 [Refereed][Not invited]
  • Jun Kunimatsu, Naoki Miyamoto, Masayori Ishikawa, Hiroki Shirato, Masaki Tanaka
    Front. Syst. Neurosci. 9 (67) 1 - 10 2015/04/24 [Refereed][Not invited]
  • Masayori Ishikawa, Naomi Nagase, Taeko Matsuura, Junichi Hiratsuka, Ryusuke Suzuki, Naoki Miyamoto, Kenneth Lee Sutherland, Katsuhisa Fujita, Hiroki Shirato
    JOURNAL OF RADIATION RESEARCH 56 (2) 372 - 381 0449-3060 2015/03 [Refereed][Not invited]
     
    The scintillator with optical fiber (SOF) dosimeter consists of a miniature scintillator mounted on the tip of an optical fiber. The scintillator of the current SOF dosimeter is a 1-mm diameter hemisphere. For a scintillation dosimeter coupled with an optical fiber, measurement accuracy is influenced by signals due to Cerenkov radiation in the optical fiber. We have implemented a spectral filtering technique for compensating for the Cerenkov radiation effect specifically for our plastic scintillator-based dosimeter, using a wavelength-separated counting method. A dichroic mirror was used for separating input light signals. Individual signal counting was performed for high-and low-wavelength light signals. To confirm the accuracy, measurements with various amounts of Cerenkov radiation were performed by changing the incident direction while keeping the Ir-192 source-to-dosimeter distance constant, resulting in a fluctuation of <5%. Optical fiber bending was also addressed; no bending effect was observed for our wavelength-separated SOF dosimeter.
  • Naoki Miyamoto, Masayori Ishikawa, Kenneth Sutherland, Ryusuke Suzuki, Taeko Matsuura, Chie Toramatsu, Seishin Takao, Hideaki Nihongi, Shinichi Shimizu, Kikuo Umegaki, Hiroki Shirato
    JOURNAL OF RADIATION RESEARCH 56 (1) 186 - 196 0449-3060 2015/01 [Refereed][Not invited]
     
    In the real-time tumor-tracking radiotherapy system, a surrogate fiducial marker inserted in or near the tumor is detected by fluoroscopy to realize respiratory-gated radiotherapy. The imaging dose caused by fluoroscopy should be minimized. In this work, an image processing technique is proposed for tracing a moving marker in low-dose imaging. The proposed tracking technique is a combination of a motion-compensated recursive filter and template pattern matching. The proposed image filter can reduce motion artifacts resulting from the recursive process based on the determination of the region of interest for the next frame according to the current marker position in the fluoroscopic images. The effectiveness of the proposed technique and the expected clinical benefit were examined by phantom experimental studies with actual tumor trajectories generated from clinical patient data. It was demonstrated that the marker motion could be traced in low-dose imaging by applying the proposed algorithm with acceptable registration error and high pattern recognition score in all trajectories, although some trajectories were not able to be tracked with the conventional spatial filters or without image filters. The positional accuracy is expected to be kept within +/- 2 mm. The total computation time required to determine the marker position is a few milliseconds. The proposed image processing technique is applicable for imaging dose reduction.
  • S. Shimizu, T. Matsuura, M. Umezawa, K. Hiramoto, N. Miyamoto, K. Umegaki, H. Shirato
    PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS 30 (5) 555 - 558 1120-1797 2014/07 [Refereed][Not invited]
     
    Purpose: Spot-scanning proton beam therapy (PBT) can create good dose distribution for static targets. However, there exists larger uncertainty for tumors that move due to respiration, bowel gas or other internal circumstances within the patients. We have developed a real-time tumor-tracking radiation therapy (RTRT) system that uses an X-ray linear accelerator gated to the motion of internal fiducial markers introduced in the late 1990s. Relying on more than 10 years of clinical experience and big log data, we established a real-time image gated proton beam therapy system dedicated to spot scanning. Materials and methods: Using log data and clinical outcomes derived from the clinical usage of the RTRT system since 1999, we have established a library to be used for in-house simulation for tumor targeting and evaluation. Factors considered to be the dominant causes of the interplay effects related to the spot scanning dedicated proton therapy system are listed and discussed. Results/conclusions: Total facility design, synchrotron operation cycle, and gating windows were listed as the important factors causing the interplay effects contributing to the irradiation time and motion-induced dose error. Fiducial markers that we have developed and used for the RTRT in X-ray therapy were suggested to have the capacity to improve dose distribution. Accumulated internal motion data in the RTRT system enable us to improve the operation and function of a Spot-scanning proton beam therapy (SSPT) system. A real-time-image gated SSPT system can increase accuracy for treating moving tumors. The system will start clinical service in early 2014. (C) 2014 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.
  • Shinichi Shimizu, Naoki Miyamoto, Taeko Matsuura, Yusuke Fujii, Masumi Umezawa, Kikuo Umegaki, Kazuo Hiramoto, Hiroki Shirato
    PLOS ONE 9 (4) 1932-6203 2014/04 [Refereed][Not invited]
     
    Purpose: A proton beam therapy (PBT) system has been designed which dedicates to spot-scanning and has a gating function employing the fluoroscopy-based real-time-imaging of internal fiducial markers near tumors. The dose distribution and treatment time of the newly designed real-time-image gated, spot-scanning proton beam therapy (RGPT) were compared with free-breathing spot-scanning proton beam therapy (FBPT) in a simulation. Materials and Methods: In-house simulation tools and treatment planning system VQA (Hitachi, Ltd., Japan) were used for estimating the dose distribution and treatment time. Simulations were performed for 48 motion parameters (including 8 respiratory patterns and 6 initial breathing timings) on CT data from two patients, A and B, with hepatocellular carcinoma and with clinical target volumes 14.6 cc and 63.1 cc. The respiratory patterns were derived from the actual trajectory of internal fiducial markers taken in X-ray real-time tumor-tracking radiotherapy (RTRT). Results: With FBPT, 9/48 motion parameters achieved the criteria of successful delivery for patient A and 0/48 for B. With RGPT 48/48 and 42/48 achieved the criteria. Compared with FBPT, the mean liver dose was smaller with RGPT with statistical significance (p<0.001); it decreased from 27% to 13% and 28% to 23% of the prescribed doses for patients A and B, respectively. The relative lengthening of treatment time to administer 3 Gy (RBE) was estimated to be 1.22 (RGPT/FBPT: 138 s/113 s) and 1.72 (207 s/120 s) for patients A and B, respectively. Conclusions: This simulation study demonstrated that the RGPT was able to improve the dose distribution markedly for moving tumors without very large treatment time extension. The proton beam therapy system dedicated to spot-scanning with a gating function for real-time imaging increases accuracy with moving tumors and reduces the physical size, and subsequently the cost of the equipment as well as of the building housing the equipment.
  • Kentaro Nishioka, Shinichi Shimizu, Nobuo Shinohara, Yoichi M. Ito, Takashige Abe, Satoru Maruyama, Rumiko Kinoshita, Keiichi Harada, Noboru Nishikawa, Naoki Miyamoto, Rikiya Onimaru, Hiroki Shirato
    JAPANESE JOURNAL OF CLINICAL ONCOLOGY 44 (1) 28 - 35 0368-2811 2014/01 [Refereed][Not invited]
     
    The real-time tumor-tracking radiotherapy system with fiducial markers has the advantage that it can be used to verify the localization of the markers during radiation delivery in real-time. We conducted a prospective Phase II study of image-guided local-boost radiotherapy for locally advanced bladder cancer using a real-time tumor-tracking radiotherapy system for positioning, and here we report the results regarding the safety and efficacy of the technique. Twenty patients with a T2-T4N0M0 urothelial carcinoma of the bladder who were clinically inoperable or refused surgery were enrolled. Transurethral tumor resection and 40 Gy irradiation to the whole bladder was followed by the transurethral endoscopic implantation of gold markers in the bladder wall around the primary tumor. A boost of 25 Gy in 10 fractions was made to the primary tumor while maintaining the displacement from the planned position at less than 2 mm during radiation delivery using a real-time tumor-tracking radiotherapy system. The toxicity, local control and survival were evaluated. Among the 20 patients, 14 were treated with concurrent chemoradiotherapy. The median follow-up period was 55.5 months. Urethral and bowel late toxicity (Grade 3) were each observed in one patient. The local-control rate, overall survival and cause-specific survival with the native bladder after 5 years were 64, 61 and 65. Image-guided local-boost radiotherapy using a real-time tumor-tracking radiotherapy system can be safely accomplished, and the clinical outcome is encouraging. A larger prospective multi-institutional study is warranted for more precise evaluations of the technological efficacy and patients quality of life.
  • Taeko Matsuura, Naoki Miyamoto, Shinichi Shimizu, Yusuke Fujii, Masumi Umezawa, Seishin Takao, Hideaki Nihongi, Chie Toramatsu, Kenneth Sutherland, Ryusuke Suzuki, Masayori Ishikawa, Rumiko Kinoshita, Kenichiro Maeda, Kikuo Umegaki, Hiroki Shirato
    MEDICAL PHYSICS 40 (7) 071729-11 - 071729-1 0094-2405 2013/07 [Refereed][Not invited]
     
    Purpose: In spot-scanning proton therapy, the interplay effect between tumor motion and beam delivery leads to deterioration of the dose distribution. To mitigate the impact of tumor motion, gating in combination with repainting is one of the most promising methods that have been proposed. This study focused on a synchrotron-based spot-scanning proton therapy system integrated with real-time tumor monitoring. The authors investigated the effectiveness of gating in terms of both the delivered dose distribution and irradiation time by conducting simulations with patients' motion data. The clinically acceptable range of adjustable irradiation control parameters was explored. Also, the relation between the dose error and the characteristics of tumor motion was investigated. Methods: A simulation study was performed using a water phantom. A gated proton beam was irradiated to a clinical target volume (CTV) of 5 x 5 x 5 cm(3), in synchronization with lung cancer patients' tumor trajectory data. With varying parameters of gate width, spot spacing, and delivered dose per spot at one time, both dose uniformity and irradiation time were calculated for 397 tumor trajectory data from 78 patients. In addition, the authors placed an energy absorber upstream of the phantom and varied the thickness to examine the effect of changing the size of the Bragg peak and the number of required energy layers. The parameters with which 95% of the tumor trajectory data fulfill our defined criteria were accepted. Next, correlation coefficients were calculated between the maximum dose error and the tumor motion characteristics that were extracted from the tumor trajectory data. Results: With the assumed CTV, the largest percentage of the data fulfilled the criteria when the gate width was +/- 2 mm. Larger spot spacing was preferred because it increased the number of paintings. With a prescribed dose of 2 Gy, it was difficult to fulfill the criteria for the target with a very small effective depth (the sum of an assumed energy absorber's thickness and the target depth in the phantom) because of the sharpness of the Bragg peak. However, even shallow targets could be successfully irradiated by employing an adequate number of paintings and by placing an energy absorber of sufficient thickness to make the effective target depth more than 12 cm. The authors also observed that motion in the beam direction was the main cause of dose distortion, followed by motion in the lateral plane perpendicular to the scan direction. Conclusions: The results suggested that by properly adjusting irradiation control parameters, gated proton spot-scanning beam therapy can be robust to target motion. This is an important first step toward establishing treatment plans in real patient geometry. (C) 2013 American Association of Physicists in Medicine.
  • Chie Toramatsu, Norio Katoh, Shinichi Shimizu, Hideaki Nihongi, Taeko Matsuura, Seishin Takao, Naoki Miyamoto, Ryusuke Suzuki, Kenneth Sutherland, Rumiko Kinoshita, Rikiya Onimaru, Masayori Ishikawa, Kikuo Umegaki, Hiroki Shirato
    RADIATION ONCOLOGY 8 (48) 1748-717X 2013/03 [Refereed][Not invited]
     
    Background: We performed a dosimetric comparison of spot-scanning proton therapy (SSPT) and intensity-modulated radiation therapy (IMRT) for hepatocellular carcinoma (HCC) to investigate the impact of tumor size on the risk of radiation induced liver disease (RILD). Methods: A number of alternative plans were generated for 10 patients with HCC. The gross tumor volumes (GTV) varied from 20.1 to 2194.5 cm(3). Assuming all GTVs were spherical, the nominal diameter was calculated and ranged from 3.4 to 16.1 cm. The prescription dose was 60 Gy for IMRT or 60 cobalt Gy-equivalents for SSPT with 95% planning target volume (PTV) coverage. Using IMRT and SSPT techniques, extensive comparative planning was conducted. All plans were evaluated by the risk of RILD estimated using the Lyman-normal-tissue complication probability model. Results: For IMRT the risk of RILD increased drastically between 6.3-7.8 cm nominal diameter of GTV. When the nominal diameter of GTV was more than 6.3 cm, the average risk of RILD was 94.5% for IMRT and 6.2% for SSPT. Conclusions: Regarding the risk of RILD, HCC can be more safely treated with SSPT, especially if its nominal diameter is more than 6.3 cm.
  • Taeko Matsuura, Kenichiro Maeda, Kenneth Sutherland, Taisuke Takayanagi, Shinichi Shimizu, Seishin Takao, Naoki Miyamoto, Hideaki Nihongi, Chie Toramatsu, Yoshihiko Nagamine, Rintaro Fujimoto, Ryusuke Suzuki, Masayori Ishikawa, Kikuo Umegaki, Hiroki Shirato
    MEDICAL PHYSICS 39 (9) 5584 - 5591 0094-2405 2012/09 [Refereed][Not invited]
     
    Purpose: In accurate proton spot-scanning therapy, continuous target tracking by fluoroscopic x ray during irradiation is beneficial not only for respiratory moving tumors of lung and liver but also for relatively stationary tumors of prostate. Implanted gold markers have been used with great effect for positioning the target volume by a fluoroscopy, especially for the cases of liver and prostate with the targets surrounded by water-equivalent tissues. However, recent studies have revealed that gold markers can cause a significant underdose in proton therapy. This paper focuses on prostate cancer and explores the possibility that multiple-field irradiation improves the underdose effect by markers on tumor-control probability (TCP). Methods: A Monte Carlo simulation was performed to evaluate the dose distortion effect. A spherical gold marker was placed at several characteristic points in a water phantom. The markers were with two different diameters of 2 and 1.5 mm, both visible on fluoroscopy. Three beam arrangements of single-field uniform dose (SFUD) were examined: one lateral field, two opposite lateral fields, and three fields (two opposite lateral fields + anterior field). The relative biological effectiveness (RBE) was set to 1.1 and a dose of 74 Gy (RBE) was delivered to the target of a typical prostate size in 37 fractions. The ratios of TCP to that without the marker (TCPr) were compared with the parameters of the marker sizes, number of fields, and marker positions. To take into account the dependence of biological parameters in TCP model, alpha/beta values of 1.5, 3, and 10 Gy (RBE) were considered. Results: It was found that the marker of 1.5 mm diameter does not affect the TCPs with all alpha/beta values when two or more fields are used. On the other hand, if the marker diameter is 2 mm, more than two irradiation fields are required to suppress the decrease in TCP from TCPr by less than 3%. This is especially true when multiple (two or three) markers are used for alignment of a patient. Conclusions: It is recommended that 1.5-mm markers be used to avoid the reduction of TCP as well as to spare the surrounding critical organs, as long as the markers are visible on x-ray fluoroscopy. When 2-mm markers are implanted, more than two fields should be used and the markers should not be placed close to the distal edge of any of the beams. (c) 2012 American Association of Physicists in Medicine. [http://dx.doi.org/10.1118/1.4745558]
  • Naoki Miyamoto, Kenneth Sutherland, Ryusuke Suzuki, Taeko Matsuura, Chie Toramatsu, Seishin Takao, Hideaki Nihongi, Rumiko Kinoshita, Shinichi Shimizu, Rikiya Onimaru, Kikuo Umegaki, Hiroki Shirato, Masayori Ishikawa
    Proc. of SPIE Medical Imaging 8312 2012 [Not refereed][Not invited]
  • Naoki Miyamoto, Masayori Ishikawa, Gerard Bengua, Kenneth Sutherland, Ryusuke Suzuki, Suguru Kimura, Shinichi Shimizu, Rikiya Onimaru, Hiroki Shirato
    PHYSICS IN MEDICINE AND BIOLOGY 56 (15) 4803 - 4813 0031-9155 2011/08 [Refereed][Not invited]
     
    In the real-time tumor-tracking radiotherapy system, fluoroscopy is used to determine the real-time position of internal fiducial markers. The pattern recognition score (PRS) ranging from 0 to 100 is computed by a template pattern matching technique in order to determine the marker position on the fluoroscopic image. The PRS depends on the quality of the fluoroscopic image. However, the fluoroscopy parameters such as tube voltage, current and exposure duration are selected manually and empirically in the clinical situation. This may result in an unnecessary imaging dose from the fluoroscopy or loss of the marker because of too much or insufficient x-ray exposure. In this study, a novel optimization method is proposed in order to minimize the fluoroscopic dose while keeping the image quality usable for marker tracking. The PRS can be predicted in a region where the marker appears to move in the fluoroscopic image by the proposed method. The predicted PRS can be utilized to judge whether the marker can be tracked with accuracy. In this paper, experiments were performed to show the feasibility of the PRS prediction method under various conditions. The predicted PRS showed good agreement with the measured PRS. The root mean square error between the predicted PRS and the measured PRS was within 1.44. An experiment using a motion controller and an anthropomorphic chest phantom was also performed in order to imitate a clinical fluoroscopy situation. The result shows that the proposed prediction method is expected to be applicable in a real clinical situation.
  • Satoshi Yamaguchi, Masayori Ishikawa, Gerard Bengua, Kenneth Sutherland, Teiji Nishio, Satoshi Tanabe, Naoki Miyamoto, Ryusuke Suzuki, Hiroki Shirato
    PHYSICS IN MEDICINE AND BIOLOGY 56 (4) 965 - 977 0031-9155 2011/02 [Refereed][Not invited]
     
    A feasibility study of a novel PET-based molecular image guided radiation therapy (m-IGRT) system was conducted by comparing PET-based digitally reconstructed planar image (PDRI) registration with radiographic registration. We selected a pair of opposing parallel-plane PET systems for the practical implementation of this system. Planar images along the in-plane and cross-plane directions were reconstructed from the parallel-plane PET data. The in-plane and cross-plane FWHM of the profile of 2 mm diameter sources was approximately 1.8 and 8.1 mm, respectively. Therefore, only the reconstructed in-plane image from the parallel-plane PET data was used in the PDRI registration. In the image registration, five different sizes of (18)F cylindrical sources (diameter: 8, 12, 16, 24, 32 mm) were used to determine setup errors. The data acquisition times were 1, 3 and 5 min. Image registration was performed by five observers to determine the setup errors from PDRI registration and radiographic registration. The majority of the mean registration errors obtained from the PDRI registration were not significantly different from those obtained from the radiographic registration. Acquisition time did not appear to result in significant differences in the mean registration error. The mean registration error for the PDRI registration was found to be 0.93 +/- 0.33 mm. This is not statistically different from the radiographic registration which had a mean registration error of 0.92 +/- 0.27 mm. Our results suggest that m-IGRT image registration using PET-based reconstructed planar images along the in-plane direction is feasible for clinical use if PDRI registration is performed at two orthogonal gantry angles.
  • Satoshi Tomioka, Samia Heshmat, Naoki Miyamoto, Shusuke Nishiyama
    APPLIED OPTICS 49 (25) 4735 - 4745 1559-128X 2010/09 [Refereed][Not invited]
     
    In the process of phase unwrapping for an image obtained by an interferometer or in-line holography, noisy image data may pose difficulties. Traditional phase unwrapping algorithms used to estimate a two-dimensional phase distribution include much estimation error, due to the effect of singular points. This paper introduces an accurate phase-unwrapping algorithm based on three techniques: a rotational compensator, unconstrained singular point positioning, and virtual singular points. The new algorithm can confine the effect of singularities to the local region around each singular point. The phase-unwrapped result demonstrates that accuracy is improved, compared with past methods based on the least-squares approach. (c) 2010 Optical Society of America
  • T. Kamiyama, N. Miyamoto, S. Tomioka, T. Kozaki
    NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT 605 (1-2) 91 - 94 0168-9002 2009/06 [Refereed][Not invited]
     
    Neutron resonance absorption spectroscopy (N-RAS) with a pulsed neutron source can distinguish the dynamics of individual nuclides having resonance peaks on epithermal neutron region. The analyzed internal information of nuclide presence and its effective temperature can be reconstructed as distributions over the object cross-section using computed tomography (CT). Because some of the resonance absorption cross-sections have very large values, N-RAS could match the small neutron pulsed source by its high sensitivity. In this study, we have constructed a new instrument of N-RAS on a compact electron linac neutron source. Resonance absorption measurements and CT imaging with the instrument have succeeded for some kinds of nuclide. (C) 2009 Elsevier B.V. All rights reserved.
  • Naoki Miyamoto, Shusuke Nisiyama, Satoshi Tomioka, Takeaki Enoto
    OPTICS COMMUNICATIONS 272 (1) 67 - 72 0030-4018 2007/04 [Refereed][Not invited]
     
    We utilize nitroanisole, that absorbs infrared (IR) radiation as heat, as an optical modulation device based on a thermal process. The nitroanisole exhibits a thermal lens effect, i.e. a temperature dependent refractive index. Hence, the nitroanisole can induce phase modulation to visible light, in direct response to intensity of the incident IR radiation. The proposed method can be used to obtain the phase modulation distribution that corresponds to the IR intensity distribution, i.e. the IR hologram itself, on the nitroanisole by examining the phase map of visible light that is modulated upon passing through the nitroanisole. The IR wavefront can be reconstructed by calculating extracted IR holograms through the Fresnel transform. It is verified that both the amplitude and the phase of the IR wavefront can be reconstructed accurately by proposed method. (c) 2006 Elsevier B.V. All rights reserved.
  • N Miyamoto, S Nisiyama, S Tomioka, T Enoto
    OPTICS COMMUNICATIONS 260 (1) 25 - 29 0030-4018 2006/04 [Refereed][Not invited]
     
    We propose the application of nitroanisole as a detector for middle infrared (mid-IR) interferometry or holography. The present experiment utilizes the liquid form of nitroanisole, which has a thermal lens effect. i.e. a temperature dependent refractive index. Since the nitroanisole absorbs IR radiation as heat, it is possible to estimate the IR intensity distribution on the nitroanisole from the diffraction pattern made by visible laser light that is transmitted through the nitroanisole. In this study, the time resolution and the diffraction efficiency of the nitroanisole was measured under various conditions. The experimental results show that the nitroanisole has a time resolution as high as that of a standard video camera, as well as a high diffraction efficiency and the spatial resolution equivalent to that of a conventional IR camera. Furthermore, we confirmed that the phase shift in mid-IR region can be estimated by analyzing the change in the visible diffraction pattern. (c) 2005 Elsevier B.V. All rights reserved.
  • Naoki Miyamoto, Shusuke Nishiyama, Satoshi Tomioka, Takeaki Enoto
    Proc. of SPIE 6049 202 - 211 2005 [Not refereed][Not invited]

Conference Activities & Talks

  • Evaluation of measurement accuracy of novel monoscopic X-ray imaging technique for three-dimensional target localization using multiple internal fiducial markers  [Not invited]
    Naoki Miyamoto, Ryusuke Suzuki, Seishin Takao, Taeko Matsuura, Shusuke Hirayama, Takaaki Fujii, Satoshi Tomioka, Shinichi Shimizu, Kikuo Umegaki, Hiroki Shirato
    第114回医学物理学会  2017/09  大阪
  • Target tumor localization algorithm using multiple fiducial markers for Real-time Tumor-tracking Radiation Therapy  [Not invited]
    Yohei Arai, Hideaki Ueda, Haruo Nakagawa, Naoki Miyamoto, Kikuo Umegaki
    第114回医学物理学会  2017/09  大阪
  • Evaluation of dosimetric error with utilizing respiratory motion modeling aimed for beam angle optimization in proton beam therapy  [Not invited]
    Haruo Nakagawa, Naoki Miyamoto, Shusuke Hirayama, Hideaki Ueda, Kohei Yokokawa, Kikuo Umegaki
    第114回医学物理学会  2017/09  大阪
  • Evaluation of the sensitivity to variable RBE considering LET dependence for the robust optimization and the PTV-based optimization  [Not invited]
    Shusuke Hirayama, Taeko Matsuura, Hideaki Ueda, Seishin Takao, Hidenori Koyano, Takaaki Fujii, Naoki Miyamoto, Shinichi Shimizu, Yusuke Fujii, Rintaro Fujimoto, Kikuo Umegaki, Hiroki Shirato
    第114回医学物理学会  2017/09  大阪
  • Evaluation of Water-Equivalent-Thickness (WET) deviation between Plan CT and Re-plan CT for prostate cancer in Spot-Scanning Proton-beam Therapy  [Not invited]
    Takaaki Fujii, Taeko Matsuura, Seishin Takao, Shusuke Hirayama, Naoki Miyamoto, Kikuo Umegaki, Shinichi Shimizu, Toru Umekawa, Hiroki Shirato
    第114回医学物理学会  2017/09  大阪
  • Monoscopic X-ray imaging for real-time three-dimensional target localization using multiple internal fiducial markers  [Not invited]
    Naoki Miyamoto, Ryusuke Suzuki, Seishin Takao, Taeko Matsuura, Takaaki Fujii, Yusuke Hirayama, Hidenori Koyano, Shinichi Shimizu, Kikuo Umegaki, Hiroki Shirato
    2017 AAPM Annual Meeting  2017/07  Denver
  • Novel 4D-CBCT reconstruction technique for moving target using fiducial-marker position  [Not invited]
    Takaaki Fujii, Seishin Takao, Taeko Matsuura, Naoki Miyamoto, Shusuke Hirayama, Shinnichi Shimizu, Kikuo Umegaki, Rika Baba, Toru Umekawa, Hiroki Shirato
    PTCOG 2017  2017/05  Yokohama
  • The Retrospective Interplay Effect Evaluation for Real-time Image-gated Proton Therapy using the Fiducial Marker Motion and Treatment Machine Log  [Not invited]
    Shusuke Hirayama, Taeko Matsuura, Hidenori Koyano, Seishin Takao, Takaaki Fujii, Naoki Miyamoto, Shinichi Shimizu, Yusuke Fujii, Takahiro Yamada, Hideaki Nihongi, Toru Umekawa, Rintaro Fujimoto, Kikuo Umegaki, Hiroki Shirato
    第113回医学物理学会  2017/04  横浜
  • Analysis software to evaluate deviation of water-equivalent thickness along proton beam path between Plan CT and CBCT for proton therapy  [Not invited]
    Takaaki Fujii, Taeko Matsuura, Seishin Takao, Naoki Miyamoto, Shusuke Hirayama, Kikuo Umegaki, Shinichi Shimizu, Toru Umekawa, Rika Baba, Hiroki Shirato
    第113回医学物理学会  2017/04  横浜
  • 体内複数マーカの軌跡データを用いた呼吸による肺の変形の再現性の評価  [Not invited]
    宮本直樹, 高尾聖心, 松浦妙子, 松崎有華, 鈴木隆介, 井上哲也, 加藤徳雄, 鬼丸力也, 清水伸一, 白土博樹
    日本放射線腫瘍学会第29回学術大会  2016/11  京都
  • 肺体幹部定位照射中における腫瘍の複雑な動きの解析と動体追跡放射線治療による対策  [Invited]
    宮本直樹
    日本放射線腫瘍学会第29回学術大会  2016/11  京都
  • 食道IMRTにおけるintra-fractional organ motionの影響  [Not invited]
    田村弘詞, 宮本直樹, 鈴木隆介, 堀田賢治, 藤田勝久, 井上哲也
    第44回日本放射線技術学会秋期学術大会  2016/10  埼玉
  • Analysis of Times and Dose Rates for Treating Moving Liver Tumors Using Real-time-image Gated Spot Scanning Proton Beam Therapy System  [Not invited]
    Shinichi Shimizu, Norio Katoh, Takayuki Hashimoto, Kentaro Nishioka, Takaaki Yoshimura, Seishin Takao, Taeko Matsuura, Naoki Miyamoto, Kikuo Umegaki, Hiroki Shirato
    58th ASTRO Annual meeting  2016/09  Boston
  • Initial Study for the System of Estimating Entrance Skin Dose from X-ray Fluoroscopy during Real-time image Gated Proton Therapy  [Not invited]
    Yuto Matsuo, Taeko Matsuura, Seishin Takao, Naoki Miyamoto, Yuka Matsuzaki, Takaaki Fujii, Shusuke Hirayama, Takaaki Yoshimura, Kikuo Umegaki, Katsuhisa Fujita, Shinichi Shimizu, Hiroki Shirato
    第112回医学物理学会  2016/09  沖縄
  • Modeling of respiratory tumor motion for dosimetric evaluation in proton beam therapy  [Not invited]
    Haruo Nakagawa, Naoki Miyamoto, Hideaki Ueda, Kohei Yokokawa, Yuka Matsuzaki, Mayuko Nagata, Kikuo Umegaki
    第112回医学物理学会  2016/09  沖縄
  • 動体追跡研究及び4DCBCT研究向け画像解析プラットフォームの開発  [Not invited]
    藤井孝明, 松浦妙子, 高尾聖心, 宮本直樹, 松崎有華, 平山嵩祐, 清水伸一, 梅垣菊男, 白土博樹
    第112回医学物理学会  2016/09  沖縄
  • Weighted tomographic image reconstruction for time varying object  [Not invited]
    Satoshi Tomioka, Daiki Naito, Shusuke Nishiyama, Naoki Miyamoto, Kikuo Umegaki
    第112回医学物理学会  2016/09  沖縄
  • 体内マーカ3次元軌跡の解析による呼吸位相評価を利用した動体追跡放射線治療の患者位置決め/ゲート照射の効率化  [Not invited]
    宮本直樹, 鈴木隆介, 高尾聖心, 松浦妙子, 松崎有華, 藤井孝明, 富岡智, 清水伸一, 梅垣菊男, 白土博樹
    第112回医学物理学会  2016/09  沖縄
  • Simulation Study of Real-time-image Gating on Spot Scanning Proton Therapy for Lung Tumors  [Not invited]
    Takahiro Kanehira, Taeko Matsuura, Seishin Takao, Yuka Matsuzaki, Yusuke Fujii, Takaaki Fujii, Naoki Miyamoto, Tetsuya Inoue, Norio Katoh, Shinichi Shmizu, Kikuo Umegaki, Hiroki Shirato
    2016 AAPM Annual Meeting  2016/07  Washington DC
  • Software development for 4D-CBCTresearchesof Real-time-image gated Spot Scanning Proton Therapy  [Not invited]
    Takaaki Fujii, Taeko Matsuura, Seishin Takao, Naoki Miyamoto, Yuka Matsuzaki, Yusuke Fujii, Kikuo Umegaki, Shinichi Shimizu, Hiroki Shirato
    2016 AAPM Annual Meeting  2016/07  Washington DC
  • An Initial Comparison Study of Motion Interplay Effects between IMPT and SFUD in Liver Real-time-image Gated, Spot-scanning Proton Beam Therapy  [Not invited]
    Taeko Matsuura, Seishin Takao, Yuka Matsuzaki, Yusuke Fujii, Takaaki Fujii, Naoki Miyamoto, Norio Katoh, Shinichi Shimizu, Hiroki Shirato, Kikuo Umegaki
    PTCOG 2016  2016/05  Czech
  • The evaluation of plan robustness for spot-scanning proton irradiation  [Not invited]
    Yuka Matsuzaki, Taeko Matsuura, Seishin Takao, Yusuke Fujii, Takaaki Fujii, Naoki Miyamoto, Shinichi Shimizu, Norio Katoh, Kikuo Umegaki, Hiroki Shirato
    PTCOG 2016  2016/05  Czech
  • 陽子線治療装置回転ガントリー搭載型二軸X線撮影装置を用いたCBCT時短撮影の実現可能性検討  [Not invited]
    高尾聖心, 清水伸一, 宮本直樹, 松浦妙子, 松崎有華, 藤井祐介, 藤井孝明, 梅垣菊男, 白土博樹
    第111回医学物理学会  2016/04  横浜
  • Dual Energy Subtraction 法を用いた動体標的認識技術の基礎検証  [Not invited]
    藤井孝明, 宮本直樹, 吉村高明, 松尾勇斗, 松浦妙子, 高尾聖心, 松崎有華, 藤井祐介, 梅垣菊男, 清水伸一, 白土博樹
    第111回医学物理学会  2016/04  横浜
  • 肝がんRGPTにおける腫瘍の動き起因の線量誤差比較-SFUD vs. IMPT  [Not invited]
    松浦妙子, 高尾聖心, 松崎有華, 藤井祐介, 藤井孝明, 宮本直樹, 金平孝博, 加藤徳雄, 清水伸一, 梅垣菊男, 白土博樹
    第111回医学物理学会  2016/04  横浜
  • スポットスキャニング陽子線治療における治療計画のRobustness評価  [Not invited]
    松崎有華, 松浦妙子, 高尾聖心, 藤井祐介, 藤井孝明, 宮本直樹, 清水伸一, 梅垣菊男, 白土博樹
    第111回医学物理学会  2016/04  横浜
  • 呼吸性移動の複雑さと対策:最新の動体追跡放射線治療  [Invited]
    宮本直樹, 高尾聖心, 原田慶一, 石川正純, 鈴木隆介, 松浦妙子, 牧永彩乃, 井上哲也, 加藤徳雄, 清水伸一, 鬼丸力也, 白土博樹
    第29回日本高精度放射線外部照射研究会  2016/02  東京
  • Development of a Real-time-image Gated Proton-beam Therapy (RGPT) system and its Initial Clinical Application to Respiratory Moving Liver Tumors  [Not invited]
    Shinichi Shimizu, Norio Katoh, Seishin Takao, Taeko Matsuura, Naoki Miyamoto, Takayuki Hashimoto, Kentaro Nishioka, Takaaki Yoshimura, Yuka Matsuzaki, Rumiko Kinoshita, Yukiko Nishikawa, Rikiya Onimaru, Kikuo Umegaki, Hiroki Shirato
    57th ASTRO Annual meeting  2015/10  San Antonio
  • Target Residual Motion During Beam Delivery in Gated Irradiation Using Real-Time Tumor-Tracking Radiotherapy System: Analysis of Simultaneous Motion of Multiple Internal Fiducial Markers  [Not invited]
    N. Miyamoto, M. Ishikawa, R. Suzuki, A. Makinaga, T. Matsuura, S. Takao, Y. Matsuzaki, T. Inoue, N. Katoh, S. Shimizu, R. Onimaru, H. Shirato
    57th ASTRO Annual meeting  2015/10  San Antonio
  • Evaluation of treatment time for real-time tumor-tracking radiotherapy  [Not invited]
    Hiroshi Tamura, Naoki Miyamoto, Ryusuke Suzuki, Kenji Horita, Katsuhisa Fujita
    第110回医学物理学会  2015/09  札幌
  • International standardization of complex real-time controlled radiotherapy systems for a moving target  [Not invited]
    Yuichi Hirata, Naoki Miyamoto, Matsuura Taeko, Yusuke Fujii, Kikuo Umegaki, Morihito Shimizu, Yoshiaki Ichikawa, Mitsuhiro Yoshida, Kazuo Hiramoto, Tsuyoshi Sasagawa, Shuji Kaneko, Yutaka Ando, Mitsuhiro Nakamura, Kenji Yokota, Teiji Nishio, Masahiro Hiraoka, Hiroki Shirato
    第110回医学物理学会  2015/09  札幌
  • Influence of patient repositioning on spot scanning proton therapy for prostate cancer  [Not invited]
    Yusuke Fujii, Taeko Matsuura, Seishin Takao, Yuka Matsuzaki, Naoki Miyamoto, Shinichi Shimizu, Kikuo Umegaki, Hiroki Shirato
    第110回医学物理学会  2015/09  札幌
  • 動体追跡放射線治療の有用性と最新の研究  [Invited]
    宮本直樹
    第110回医学物理学会  2015/09  札幌
  • Influence of the Intrafraction Patient Repositioning On Spot Scanning Proton Therapy for Prostate Cancer  [Not invited]
    Y Fujii, T Matsuura, S Takao, Y Matsuzaki, T Yamada, N Miyamoto, S Shimizu, K Umegaki, H Shirato
    2015 AAPM Annual Meeting  2015/07  Anaheim
  • Startup Experience of the New Proton Beam Therapy System with Gated Spot Scanning and Real-Time Tumor-Tracking  [Not invited]
    K Umegaki, T Matsuura, S Takao, Y Matsuzaki, T Yamada, Y Fujii, N Miyamoto, S Shimizu, H Shirato
    2015 AAPM Annual Meeting  2015/07  Anaheim
  • Development of An Applicator for Treating Shallow and Moving Tumors with Respiratory-Gated Spot-Scanning Proton Therapy Using Real-Time Image Guidance  [Not invited]
    T Matsuura, Y Fujii, S Takao, T Yamada, Y Matsuzaki, N Miyamoto, T Takayanagi, S Fujitaka, S Shimizu, H Shirato, K Umegaki
    2015 AAPM Annual Meeting  2015/07  Anaheim
  • Development of Evaluation System of Optimal Synchrotron Controlling Parameter for Spot Scanning Proton Therapy with Multiple Gate Irradiations in One Operation Cycle  [Not invited]
    T Yamada, N Miyamoto, T Matsuura, S Takao, Y Matsuzaki, Y Fujii, H Koyano, H Nihongi, M Umezawa, K Matsuda, K Umegaki, H Shirato
    2015 AAPM Annual Meeting  2015/07  Anaheim
  • Development and Commissioning of Real-Time Imaging Function for Respiratory-Gated Spot-Scanning Proton Beam Therapy  [Not invited]
    N Miyamoto, S Takao, T Matsuura, Y Matsuzaki, T Yamada, Y Fujii, Y Matsuo, T Kidani, Y Egashira, T Umekawa, S Shimizu, H Shirato, K Umegaki
    2015 AAPM Annual Meeting  2015/07  Anaheim
  • Commissioning & QA for SyncTraX for SRS  [Invited]
    Naoki Miyamoto, Masayori Ishikawa, Ryusuke Suzuki, Hiroshi Tamura, Katsuhisa Fujita, Tetsuya Inoue, Norio Katoh, Shinichi Shimizu, Rikiya Onimaru, Hiroki Shirato
    12th International Stereotactic Radiosurgery Society Congress  2015/06  Yokohama
  • Feasibility of fast cone-beam CT image acquisition with a dual-orthogonal fluoroscopic imaging system equipped on rotating gantry of proton beam therapy system  [Not invited]
    Seishin Takao, Shinichi Shimizu, Takahiro Yamada, Naoki Miyamoto, Taeko Matsuura, Yuka Matsuzaki, Yusuke Fujii, Toru Umekawa, Rika Baba, Kikuo Umegaki, Hiroki Shirato
    54th PTCOG  2015/05  San Diego
  • The Establishment of Patient-specific QA for Spot-Scanning Proton Beam Irradiation System at Hokkaido University  [Not invited]
    Yuka Matsuzaki, Taeko Matsuura, Seishin Takao, Takahiro Yamada, Yusuke Fujii, Naoki Miyamoto, Yuto Matsuo, Takaaki Yoshimura, Kikuo Umegaki, Hiroki Shirato
    54th PTCOG  2015/05  San Diego
  • Startup experience of gated spot scanning proton beam therapy system with real-time tumor-tracking  [Not invited]
    Kikuo Umegaki, Taeko Matsuura, Seishin Takao, Yuka Matsuzaki, Naoki Miyamoto, Takahiro Yamada, Yusuke Fujii, Shinichi Shimizu, Hiroki Shirato
    54th PTCOG  2015/05  San Diego
  • Machine QA for Spot-Scanning Proton Beam Irradiation System at Hokkaido University  [Not invited]
    Takahiro Yamada, Yuka Matsuzaki, Taeko Matsuura, Seishin Takao, Naoki Miyamoto, Yuto Matsuo, Takaaki Yoshimura, Kikuo Umegaki, Hiroki Shirato
    54th PTCOG  2015/05  San Diego
  • Commissioning of the on-board cone-beam CT system equipped on the rotating gantry of a proton beam therapy system  [Not invited]
    Takao S, Shimizu S, Miyamoto N, Matsuura T, Matsuzaki Y, Yamada T, Fujii Y, Matsuo Y, Umegaki K, Shirato H
    第109回医学物理学会  2015/04  横浜
  • Development of a short range applicator for real-time-image gated proton beam therapy  [Not invited]
    Taeko Matsuura, Yusuke Fujii, Seishin Takao, Yuka Matsuzaki, Takahiro Yamada, Naoki Miyamoto, Yuto Matsuo, Shinichiro Fujitaka, Tisuke Takayanagi, Kikuo Umegaki, Hiroki Shirato
    第109回医学物理学会  2015/04  横浜
  • 体内マーカー運動に基づく呼吸位相評価法の開発と待ち伏せ照射の高精度化への応用  [Not invited]
    宮本直樹, 石川正純, 鈴木隆介, 高尾聖心, 松浦妙子, 平田雄一, 加藤徳雄, 清水伸一, 梅垣菊男, 白土博樹
    第109回医学物理学会  2015/04  横浜
  • 北海道大学病院陽子線治療センターの動体追跡装置のコミッショニング  [Not invited]
    宮本直樹, 高尾聖心, 松浦妙子, 松崎有華, 山田貴啓, 藤井祐介, 松尾勇斗, 清水伸一, 梅垣菊男, 白土博樹
    第109回医学物理学会  2015/04  横浜
  • 体追跡放射線治療システムの臨床応用と今後の展望  [Invited]
    宮本直樹, 石川正純, 井上哲也, 加藤徳雄, 清水伸一, 鬼丸力也
    日本放射線腫瘍学会第27回学術大会  2014/12  横浜
  • Validation of treatment planning system of a spot-scanning proton therapy at Hokkaido University  [Not invited]
    Takahiro Yamada, Taeko Matsuura, Chie Toramatsu, Seishin Takao, Naoki Miyamoto, Shinichi Shimizu, Kikuo Umegaki, Hiroki Shirato
    7th Korea-Japan Meeting on Medical Physics  2014/09  Busan, Korea
  • Quality control of a next generation Realtime tumor tracking radiotherapy system  [Not invited]
    Suguru Kimura, Naoki Miyamoto, Kenneth Sutherland, Ryusuke Suzuki, Hiroki Shirato, Masayori Ishikawa
    7th Korea-Japan Meeting on Medical Physics  2014/09  Busan, Korea
  • Fundamental study of a new gating irradiation method in Real-Time tumor tracking radiotherapy (RTRT) system by using multiple internal fiducial marker  [Not invited]
    Kanako Otomo, Naoki Miyamoto, Masayori Ishikawa, Kenneth Sutherland, Ryusuke Suzuki, Taeko Matsuura, Rikiya Onimaru, Shinichirou Shimizu, Hiroki Shirato
    7th Korea-Japan Meeting on Medical Physics  2014/09  Busan, Korea
  • Dosimetric evaluation of the moving target in beam gating irradiation system  [Not invited]
    Naoki Miyamoto, Masayori Ishikawa, Ryusuke Suzuki, Yuichi Hirata, Tsuyoshi Sasagawa, Seiji Yamanaka, Hiroshi Tamura, Katsuhisa Fujita, Tetsuya Inoue, Norio Katoh, Hiroki Shirato
    7th Korea-Japan Meeting on Medical Physics  2014/09  Busan, Korea
  • Validation of beam accuracy of a gated spot-scanning proton therapy system with real-time tumor-tracking at Hokkaido University  [Not invited]
    Takahiro Yamada, Taeko Matsuura, Seishin Takao, Naoki Miyamoto, Chie Toramatsu, Shinichi Shimizu, Hideaki Nihongi, Taisuke Takayanagi, Masumi Umezawa, Koji Matsuda, Kikuo Umegaki, Hiroki Shirato
    AAPM 56th Annual Meeting,  2014/07  Austin
  • Commissioning of the On-board Cone-beam CT System Equipped on the Rotating Gantry of a Proton Therapy System  [Not invited]
    Takao S, Shimizu S, Miyamoto N, Matsuura T, Toramatsu C, Nihongi H, Yamada T, Matsuda K, Sasaki T, Nagamine Y, Baba R, Umekawa T, Umegaki K, Shirato H
    AAPM 56th Annual Meeting,  2014/07  Austin
  • A real-time patient positioning and monitoring system utilizing fluoroscopy  [Not invited]
    Kenneth Sutherland, Naoki Miyamoto, Hiroki Shirato
    CARS 2014  2014/06  Fukuoka
  • Clinical Commissioning of Hokkaido University Hospital Proton Therapy Center  [Not invited]
    Chie Toramatsu, Taeko Matsuura, Seishin Takao, Hideaki Nihongi, Takahiro Yamada, Naoki Miyamoto, Kikuo Umegaki, Rumiko Kinoshita, Shinichi Shimizu, Hiroki Shirato
    PTCOG 53  2014/06  Shanghai
  • Validation of beam performance of a new spot-scanning proton therapy system at Hokkaido University  [Not invited]
    Takahiro Yamada, Chie Toramatsu, Taeko Matsuura, Seishin Takao, Naoki Miyamoto, Hideaki Nihongi, Masumi Umezawa, Koji Matsuda, Kikuo Umegaki, Shinichi Shimizu, Hiroki Shirato
    PTCOG 53  2014/06  Shanghai
  • 北海道大学における分子追跡放射線治療装置のビーム性能の検証  [Not invited]
    二本木英明, 寅松千枝, 松浦妙子, 高尾聖心, 宮本直樹, 山田貴啓, 清水伸一, 梅垣菊男, 白土博樹, 松田浩二, 梅澤真澄
    第107回医学物理学会  2014/04  横浜
  • 北海道大学病院陽子線治療センターのクリニカルコミッショニング  [Not invited]
    寅松千枝, 松浦妙子, 高尾聖心, 二本木英明, 山田貴啓, 宮本直樹, 清水伸一, 梅垣菊男, 白土博樹
    第107回医学物理学会  2014/04  横浜
  • 次世代動体追跡装置のアクセプタンス/コミッショニング  [Not invited]
    石川 正純, 宮本 直樹, 篠川 毅, 山中 誓次, 堀田 賢治, 藤田 勝久, 鈴 木隆介, 鬼丸 力也, 井上 哲也, 白土 博樹
    第107回医学物理学会  2014/04  横浜
  • Development of a dynamic phantom for quality control in 4D radiotherapy  [Not invited]
    Naoki Miyamoto, Yuichi Hirata, Ryusuke Suzuki, Chie Toramatsu, Yuki Miyabe, Shuji Kaneko, Teiji Nishio, Shinichi Shimizu, Masayori Ishikawa, Hiroki Shirato
    第107回医学物理学会  2014/04  横浜
  • 3点の体内マーカーを用いた患者セットアップの有効性評価  [Not invited]
    加藤英斗, 宮本直樹, 大友加奈子, 鈴木隆介, 西岡健太郎, 清水伸一, 鬼丸力也, 石川正純, 白土博樹
    第27回日本高精度外部照射研究会  2014/02  東京
  • 次世代型RTRT:SyncTraXの開発から臨床応用へ  [Invited]
    宮本直樹, 石川正純, 井上哲也, 加藤徳雄, 清水伸一, 鬼丸力也, 白土博樹
    第27回日本高精度外部照射研究会  2014/02  東京
  • Development of a dynamic phantom for quality control in 4D radiotherapy  [Not invited]
    Naoki Miyamoto, Yuichi Hirata, Ryusuke Suzuki, Chie Toramatsu, Takashi Kozuka, Yuki Miyabe, Shuji Kaneko, Teiji Nishio, Shinichi Shimizu, Masayori Ishikawa, Hiroki Shirato
    4D (Treatment Planning) workshop  2013/11  Switzerland
  • Evaluation of the measurement accuracy of a novel monoscopic x-ray imaging system for real-time tumor-tracking radiotherapy  [Not invited]
    Naoki Miyamoto, Masayori Ishikawa, Kenneth Sutherland, Ryusuke Suzuki, Taeko Matsuura, Seishin Takao, Chie Toramatsu, Hideaki Nihongi, Shinichi Shimizu, Kikuo Umegaki, Hiroki Shirato
    4D (Treatment Planning) workshop  2013/11  Switzerland
  • 動体追跡装置における透視X線による患者被ばく線量の評価  [Not invited]
    木村傑, 宮本直樹, 鈴木隆介, 石川正純, 寅松千枝, 松浦妙子, 高尾聖心, 白土博樹
    第106回医学物理学会  2013/10  大阪
  • 陽子線治療が求められる腫瘍体積  [Not invited]
    寅松千枝, 加藤徳雄, 清水伸一, 二本木英明, 松浦妙子, 高尾聖心, 宮本直樹, 鈴木隆介, 木下留美子, 鬼丸力也, 石川正純, 梅垣菊男, 白土博樹
    日本放射線腫瘍学会第26回学術大会  2013/10  青森
  • 動体迎撃照射の現状と未来  [Invited]
    宮本直樹
    日本放射線腫瘍学会第26回学術大会  2013/10  青森
  • Baseline shift of intrafractional lung tumor motion in the real-time tumor-tracking radiotherapy  [Not invited]
    Seishin Takao, Naoki Miyamoto, Taeko Matsuura, Shinichi Shimizu, Rikiya Onimaru, Norio Katoh, Tetsuya Inoue, Hiroki Shirato
    55th ASTRO Annual Meeting  2013/09  Atlanta
  • Can 4D CT Imaging Predict Lung Motion During Stereotactic Body Radiation Therapy?  [Not invited]
    K. Harada, N. Katoh, R. Suzuki, T. Inoue, R. Onimaru, S. Shimizu, N. Miyamoto, M.Ishikawa, H. Shirato
    55th ASTRO Annual Meeting  2013/09  Atlanta
  • Conformal Therapy (ECT) and Spot Scanning Proton Therapy for Post-mastectomy Chest Wall Irradiation  [Not invited]
    Chie Toramatsu, Shinichi Shimizu, Taeko Matsuura, Naoki Miyamoto, Rumiko Kinoshita, Seishin Takao, Hideaki Nihongi, Kikuo Umegaki, Hiroki Shirato
    55th ASTRO Annual Meeting  2013/09  Atlanta
  • Simulation of spot scanning proton-beam therapy for moving targets - using organ motion log data gathered with the RTRT system  [Not invited]
    S. Shimizu, T. Matsuura, N. Katoh, R. Kinoshita, S. Onodera, R. Onimaru, N. Miyamoto, C. Toramatsu, S. Takao, H. Nihongi, R. Fujimoto, Y. Nagamine, M. Umezawa, K. Hiramoto, K. Umegaki, H. Shirato
    PTCOG 52  2013/06  Germany
  • Baseline shift of intrafractional lung tumor motion in the real-time tumor-tracking radiotherapy  [Not invited]
    Seishin Takao, Shinichi Shimizu, Naoki Miyamoto, Taeko Matsuura, Chie Toramatsu, Hideaki Nihongi, Kikuo Umegaki, Hiroki Shirato
    PTCOG 52  2013/06  Germany
  • Development of the device for Spot-scanning proton irradiation to shallow seated tumor  [Not invited]
    Chie Toramatsu, Rikiya Onimaru, Shinichi Shimizu, Taeko Matsuura, Naoki Miyamoto, Rumiko Kinoshita, Seishin Takao, Hideaki Nihongi, Kikuo Umegaki, Hiroki Shirato, Rintaro Fujimoto, Shunsuke Hirayama, Yusuke Fujii, Taisuke Takayanagi, Masumi Umezasa, Koji Matsuda, Yoshihiko Nagamine
    PTCOG 52  2013/06  Germany
  • Real-time tumor-tracking radiotherapy system with mono X-ray fluoroscopy  [Not invited]
    Naoki Miyamoto, Masayori Ishikawa, Kenneth Sutherland, Ryusuke Suzuki, Taeko Matsuura, Seishin Takao, Chie Toramatsu, Hideaki Nihongi, Shinichi Shimizu, Kikuo Umegaki, Hiroki Shirato
    第105回医学物理学会  2013/04  横浜
  • A study on a gated proton spot-scanning beam therapy integrated with a real-time tumor-monitoring: an initial phantom study using patient tumor trajectory data  [Not invited]
    Taeko Matsuura, Naoki Miyamoto, Shinichi Shimizu, Yusuke Fujii, Masumi Umezawa, Seishin Takao, Hideaki Nihongi, Chie Toramatsu, Kikuo Umegaki, Hiroki Shirato
    第105回医学物理学会  2013/04  横浜
  • 照射中と4DCT撮影時の肺内マーカ移動の比較  [Not invited]
    原田慶一, 加藤徳男, 鈴木隆介, 井上哲也, 鬼丸力也, 清水伸一, 宮本直樹, 石川正純, 白土博樹
    第26回日本高精度放射線外部照射研究会  2013/02  京都
  • Progress report on collaborative development activities in improvement of spot-scanning proton therapy system Simulation of spot-scanning proton-beam therapy to the moving target using organ motion log-data obtained by an RTRT system  [Not invited]
    Chie Toramatsu, Rintaro Fujimoto, Rikiya Onimaru, Shinichi Shimizu, Taeko Matsuura, Naoki Miyamoto, Rumiko Kinoshita, Seishin Takao, Hideaki Nihongi, Kikuo Umegaki, Hiroki Shirato, Shunsuke Hirayama, Yusuke Fujii, Taisuke Takayanagi, Masumi Umezawa, Koji Matsuda, Yoshihiko Nagamine
    Third International Conference on Real-time Tumor-tracking Radiation Therapy with 4D Molecular Imaging Technique  2013/02  Sapporo
  • Simulation of spot-scanning proton-beam therapy to the moving target using organ motion log-data obtained by an RTRT system  [Not invited]
    Shinichi Shimizu, Taeko Matsuura, Norio Katoh, Rumiko Kinoshita, Shunsuke Onodera, Rikiya Onimaru, Naoki Miyamoto, Chie Toramatsu, Seishin Takao, Hideaki Nihongi, Rintaro Fujimoto, Yoshihiko Nagamine, Masumi Umezawa, Kazuo Hiramoto, Kikuo Umegaki, Hiroki Shirato
    Third International Conference on Real-time Tumor-tracking Radiation Therapy with 4D Molecular Imaging Technique  2013/02  Sapporo
  • A study on a gated proton spot-scanning beam therapy integrated with a real-time tumor-monitoring: an initial phantom study using patient tumor trajectory data  [Not invited]
    Taeko Matsuura, Naoki Miyamoto, Shinichi Shimizu, Yusuke Fujii, Masumi Umezawa, Seishin Takao, Hideaki Nihongi, Chie Toramatsu, Kenneth Sutherland, Kikuo Umegaki, Hiroki Shirato
    Third International Conference on Real-time Tumor-tracking Radiation Therapy with 4D Molecular Imaging Technique  2013/02  Sapporo
  • Preparation of Manuals for Treatment Planning at Hokkaido University  [Not invited]
    Nihongi H, Toramatsu C, Matsuura T, Takao S, Miyamoto N, Umegaki K, Shimizu S, Kinoshita R, Onodera S, Shirato H
    Third International Conference on Real-time Tumor-tracking Radiation Therapy with 4D Molecular Imaging Technique  2013/02  Sapporo
  • Development of dynamic phantom for safety management in four-dimensional radiotherapy  [Not invited]
    Naoki Miyamoto, Yuichi Hirata, Ryusuke Suzuki, Chie Toramatsu, Satoru Utsunomiya, Mitsuhiro Nakamura, Yuki Miyabe, Teiji Nishio, Takashi Kozuka, Shuji Kaneko, Takashi Mizowaki, Shinichic Shimizu, Masayori Ishikawa, Masahiro Hiraoka, Hiroki Shirato
    Third International Conference on Real-time Tumor-tracking Radiation Therapy with 4D Molecular Imaging Technique  2013/02  Sapporo
  • The Role of Spot Scanning Proton Therapy in the Treatment of Large tumors:A Comparative Planning Study of Hepatocellular Carcinoma  [Not invited]
    Toramatsu C, Katoh N, Shimizu S, Nihongi H, Matsuura T, Takao S, Miyamoto N, Kinoshita R, Umegaki K, Shirato H
    54th ASTRO Annual Meeting  2012/10  Boston
  • 北海道大学における分子追跡陽子線治療装置  [Not invited]
    二本木英明, 寅松千枝, 松浦妙子, 高尾聖心, 宮本直樹, 梅垣菊男, 清水伸一, 木下留美子, 小野寺俊輔, 白土博樹, 松田浩二, 梅澤真澄, 平本和夫
    第9回日本粒子線治療臨床研究会  2012/10  指宿
  • 一方向X線透視による低被曝・省スペース型動体追跡装置の開発  [Not invited]
    宮本直樹, 石川正純, Kenneth Sutherland, 鈴木隆介, 松浦妙子, 高尾聖心, 寅松千枝, 二本木英明, 清水伸一, 梅垣菊男, 白土博樹
    第104回医学物理学会  2012/09  つくば
  • 陽子線治療における最適な治療ワークフローの検討  [Not invited]
    高尾聖心, 松浦妙子, 寅松千枝, 二本木英明, 宮本直樹, 清水伸一, 木下留美子, 松田浩二, 木谷貴雄, 梅垣菊男, 白土博樹
    第104回医学物理学会  2012/09  つくば
  • 複数体内マーカを利用した腫瘍の呼吸性運動の詳細解析とゲーティング照射の有用性の検討  [Not invited]
    大友可奈子, 宮本直樹, 石川正純, Kenneth Sutherland, 鈴木隆介, 松浦妙子, 鬼丸力也, 清水伸一, 梅垣菊男, 白土博樹
    第104回医学物理学会  2012/09  つくば
  • Accelerated Computation of Digitally Reconstructed Radiographs with a GPU  [Not invited]
    Kenneth Sutherland, 宮本直樹, 石川正純, 鈴木隆介, 白土博樹
    第104回医学物理学会  2012/09  つくば
  • 陽子線スキャニング照射における体内マーカーによる線量遮蔽のTCPを用いた評価  [Not invited]
    前田憲一郎, 松浦妙子, Kenneth Sutherland, 高尾聖心, 寅松千枝, 二本木英明, 宮本直樹, 清水伸一, 石川正純, 梅垣菊男, 白土博樹
    第104回医学物理学会  2012/09  つくば
  • Development of The Compact Proton Beam Therapy System Dedicated to Spot Scanning with Real-time Tumor-tracking Technology  [Not invited]
    Umezawa M, Fujimoto R, Umekawa T, Fujii Y, Takayanagi T, Ebina F, Aoki T, Nagamine Y, Matsuda K, Hiramoto K, Matsuura T, Miyamoto N, Nihongi H, Umegaki K, iShirato H
    22nd International Conference on the Application of Accelerators in Research and Industry  2012/08  Texas
  • Motion adaptive image filter for low dose X-ray fluoroscopy in real-time tumor-tracking radiotherapy system  [Not invited]
    Naoki Miyamoto, Masayori Ishikawa, Kenneth Sutherland, Ryusuke Suzuki, Taeko Matsuura, Seishin Takao, Chie Toramatsu, Hideaki Nihongi, Shinichi Shimizu, Rikiya Onimaru, Kikuo Umegaki, Hiroki Shirato
    AAPM 54th Annual Meeting,  2012/07  Charlotte
  • Biological Effect of Dose Shadowing by Fiducial Markers in Spot Scanning Proton Therapy with a Limited Number of Fields  [Not invited]
    T Matsuura, K Maeda, K Sutherland, T Takayanagi, S Shimizu, S Takao, H Nihongi, C Toramatsu, N Miyamoto, Y Nagamine, R Fujimoto, K Umegaki, H Shirato
    AAPM 54th Annual Meeting,  2012/07  Charlotte
  • Dosimetric Study for Shallow-Seated Tumor Using Passive/active Scanning Proton Beam  [Not invited]
    C Toramatsu, T Matsuura, H Nihongi, S Takao, N Miyamoto, S Shimizu, R Kinoshita, K Umegaki, H Shirato
    AAPM 54th Annual Meeting,  2012/07  Charlotte
  • DEVELOPMENT OF DYNAMIC PHANTOM FOR QUALITY CONTROL IN FOUR-DIMENSIONAL RADIOTHERAPY  [Not invited]
    Naoki Miyamoto, Yuichi Hirata, Kenji Naoe, Ryusuke Suzuki, Chie Toramatsu, Shinichi Shimizu, Yuki Miyabe, Shuji Kaneko, Teiji Nishio, Masayori Ishikawa, Masahiro Hiraoka, Hiroki Shirato
    31th Sapporo International Cancer Symposium  2012/07  Sapporo
  • Spot-scanning Proton Therapy for Mobile Tumors -Reduction of Interplay Effect by Gating Technique-  [Not invited]
    Taeko Matsuura, Naoki Miyamoto, Shinichi Shimizu, Chie Toramatsu, Seishin Takao, Hideaki Nihongi, Rumiko Kinoshita, Rikiya Onimaru, Masumi Umezawa, Rintaro Fujimoto, Koji Matsuda, Kikuo Umegaki, Hiroki Shirato
    31th Sapporo International Cancer Symposium  2012/07  Sapporo
  • Usability of Treatment Procedure in Spot Scanning Proton Beam Therapy System  [Not invited]
    Seishin Takao, Shinichi Shimizu, Taeko Matsuura, Chie Toramatsu, Hideaki Nihongi, Naoki Miyamoto, Koji Matsuda, Toru Umekawa, Kikuo Umegaki, Hiroki Shirato
    31th Sapporo International Cancer Symposium  2012/07  Sapporo
  • A Comparative Planning Study of Large abdominal tumors _ The role of Proton Therapy in the Treatment of Large Irradiation Volumes  [Not invited]
    Chie Toramatsu, Hideaki Nihongi, Taeko Matsuura, Seishin Takao, Naoki Miyamoto, Kikuo Umegaki, Norio Katoh, Shinichi Shimizu, Rumiko Kinoshita, Hiroki Shirato
    31th Sapporo International Cancer Symposium  2012/07  Sapporo
  • PREPARATION FOR A PROTON SCANNING TREATMENT PLANNING SYSTEM AT HOKKDAIDO UNIVERSITY  [Not invited]
    Hideaki Nihongi, Chie Toramatsu, Taeko Matsuura, Seishin Takao, Naoki Miyamoto, Kikuo Umegaki, Shinichi Shimizu, Rumiko Kinoshita, Shunsuke Onodera, Hiroki Shirato
    31th Sapporo International Cancer Symposium  2012/07  Sapporo
  • Web-based database system for inter-fractional organ motion estimated by real-time tumor-tracking radiotherapy system  [Not invited]
    Ryusuke Suzuki, Masayori Ishikawa, Naoki Miyamoto, Kenneth Lee Sutherland, Taeko Matsuura, Seishin Takao, Chie Toramatsu, Hideaki Nihongi, Shinichi Shimizu, Rikiya Onimaru, Hiroki Shirato
    31th Sapporo International Cancer Symposium  2012/07  Sapporo
  • Development of international standardization of Four Dimensional Radiotherapy  [Not invited]
    Yuichi Hirata, Takashi Kozuka, Kenji Naoe, Naoki Miyamoto, Chie Toramatsu, Ryusuke Suzuki, Shinichi Shimizu, Yuki Miyabe, Shuji Kaneko, Takashi Mizowaki, Masahiro Hiraoka, Mitsuhiro Yoshida, Kazuo Hiramoto, Tsuyoshi Sasagawa, Hiroki Shirato
    31th Sapporo International Cancer Symposium  2012/07  Sapporo
  • Motion adaptive image filter for low dose X-ray fluoroscopy in real-time tumor-tracking radiotherapy system  [Not invited]
    Naoki Miyamoto, Kenneth Sutherland, Ryusuke Suzuki, Taeko Matsuura, Chie Toramatsu, Seishin Takao, Hideaki Nihongi, Rumiko Kinoshita, Shinichi Shimizu, Rikiya Onimaru, Kikuo Umegaki, Hiroki Shirato, Masayori Ishikawa
    The 6th S. Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium  2012/07  Hiroshima
  • Development of the Compact Proton Beam Therapy System Dedicated to Spot Scanning with Real Time Tumor Tracking Technology  [Not invited]
    Yusuke Fujii, Futaro Ebina, Rintaro Fujimoto, Masumi Umezawa, Kazuo Hiramoto, Yoshihiko Nagamine, Koji Matsuda, Taeko Matsuura, Naoki Miyamoto, Hideaki Nihongi, Kikuo Umegaki, Hiroki Shirato
    The 6th S. Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium  2012/07  Hiroshima
  • Development of Spot Scanning Proton Beam Therapy System with Real-Time Tumor-Tracking Technology  [Not invited]
    Hiroki Shirato, Kikuo Umegaki, Shinichi Shimizu, Taeko Matsuura, Naoki Miyamoto, Chie Toramatsu, Seishin Takao, Hideaki Nihongi, Kazuo Hiramoto, Fumito Nakamura
    PTCOG 51  2012/05  Seoul, Korea
  • On reduction of irradiation time in Real-time Tumor-tracking Proton beam Therapy  [Not invited]
    Taeko Matsuura, Naoki Miyamoto, Shinichi Shimizu, Chie Toramatsu, Seishin Takao, Hideaki Nihongi, Masumi Umezawa, Yusuke Fujii, Kikuo Umegaki, Hiroki Shirato
    PTCOG 51  2012/05  Seoul, Korea
  • Design of treatment workflow in proton therapy system with compact rotating gantry  [Not invited]
    Seishin Takao, Shinichi Shimizu, Chie Toramatsu, Taeko Matsuura, Hideaki Nihongi, Naoki Miyamoto, Koji Matsuda, Toru Umekawa, Kikuo Umegaki, Hiroki Shirato
    PTCOG 51  2012/05  Seoul, Korea
  • A Comparative Planning Study of Large abdominal tumors  [Not invited]
    Toramatsu C, Katoh N, Shimizu S, Nihongi H, Matsuura T, Takao S, Miyamoto N, Kinoshita R, Umegaki K, Shirato H
    PTCOG 51  2012/05  Seoul, Korea
  • Performance and dose distribution evaluation of scanning dedicated compact proton therapy system by treatment planning simulation  [Not invited]
    Hideaki Nihongi, Chie Toramatsu, Taeko Matsuura, Seishin Takao, Naoki Miyamoto, Kikuo Umegaki, Shinichi Shimizu, Rumiko Kinoshita, Hiroki Shirato
    PTCOG 51  2012/05  Seoul, Korea
  • Accuracy Verification of the Marker Tracking System Mounted on the Rotating Gantry  [Not invited]
    Toru Umekawa, Takao Kidani, Toshie Sasaki, Yoshihiko Nagamine, Masumi Umezawa, Kazuo Hiramoto, Naoki Miyamoto, Seishin Takao, Shinichi Shimizu, Kikuo Umegaki, Hiroki Shirato
    PTCOG 51  2012/05  Seoul, Korea
  • Dose distribution analysis of moving target irradiated by proton spot scanning combined with gating technique  [Not invited]
    Yusuke Fujii, Toru Umekawa, Rintaro Fujimoto, Yoshihiko Nagamine, Masumi Umezawa, Kazuo Hiramoto, Hiroshi Akiyama, Naoki Miyamoto, Taeko Matsuura, Kikuo Umegaki, Hiroki Shirato
    PTCOG 51  2012/05  Seoul, Korea
  • 高精度X線治療機器の開発  [Invited]
    宮本直樹
    第51回日本生体医工学会大会  2012/05  福岡
  • 治療計画シミュレーションによる陽子線スキャニング専用機の線量分布の検証  [Not invited]
    二本木英明, 寅松千枝, 松浦妙子, 高尾聖心, 宮本直樹, 梅垣菊男, 清水伸一, 木下留美子, 白土博樹
    第103回医学物理学会  2012/04  横浜
  • フリームービング条件下における時計遺伝子発現の新規非侵襲 4D イメージング  [Not invited]
    浜田俊幸, 本間さと, Kenneth Sutherland, 宮本直樹, 石川正純, 白土博樹, 本間研一
    第89回日本生理学会大会  2012/03  長野
  • IGRT and Real time 4DRT with RTRT  [Not invited]
    Shimizu S, Onimaru R, Kinoshita R, Kato N, Inoue T, Nishioka K, Matsuura T, Miyamoto N, Kenneth Sutherland, Toramatsu C, Takao S, Nihongi H, Umegaki K, Shirato H
    Second International Conference on Real-time Tumor-tracking Radiation Therapy with 4D Molecular Imaging Technique  2012/02  Kyoto
  • Real-time Tumor-tracking Radiotherapy (RTRT) for Non-smoll Cell Lung Cancer(NSCLC)  [Not invited]
    Onimaru R, Shimizu S, Kinoshita R, Kato N, Inoue T, Nishioka K, Matsuura T, Miyamoto N, Kenneth Sutherland, Toramatsu C, Takao S, Nihongi H, Umegaki K, Shirato H
    Second International Conference on Real-time Tumor-tracking Radiation Therapy with 4D Molecular Imaging Technique  2012/02  Kyoto
  • Progress Report on Collaborative Research Activities in RTPT I-Synchrotron-based Compact Proton Therapy System Dedicated to Spot Scanning-  [Not invited]
    Umezawa M, Fujimoto R, Umekawa T, Fujii Y, Takayanagi T, Ebina F, Aoki T, Nagamine Y, Matsuda K, Hiramoto K, Matsuura T, Miyamoto N, Nihongi H, Umegaki K, Shirato H
    Second International Conference on Real-time Tumor-tracking Radiation Therapy with 4D Molecular Imaging Technique  2012/02  Kyoto
  • Progress Report on Collaborative Research Activities in RTPT II -Integration of RTRT and Spot Scanning Proton Therapy-  [Not invited]
    Matsuura T, Miyamoto N, Kenneth Sutherland, Toramatsu C, Takao S, Nihongi H, Shimizu S, Kinoshita R, Onimaru R, Umezawa M, Fujimoto R, Hiramoto K, Nagamine Y, Matsuda K, Umegaki K, Shirato H
    Second International Conference on Real-time Tumor-tracking Radiation Therapy with 4D Molecular Imaging Technique  2012/02  Kyoto
  • 分子イメージング画像を用いた高精度画像誘導放射線治療  [Not invited]
    石川正純, 山口哲, 棚邊哲史, 山中琢, 宮本直樹, 鈴木隆介, Kenneth Sutherland, 加藤徳雄, 白土博樹
    第24回日本高精度放射線外部照射研究会  2012/02  横浜
  • Improvement of tracking accuracy and stability by recursive image processing in real-time tumor-tracking radiotherapy system  [Not invited]
    Naoki Miyamoto, Kenneth Sutherland, Ryusuke Suzuki, Taeko Matsuura, Chie Toramatsu, Seishin Takao, Hideaki Nihongi, Rumiko Kinoshita, Shinichi Shimizu, Rikiya Onimaru, Kikuo Umegaki, Hiroki Shirato, Masayori Ishikawa
    SPIE Medical Imaging  2012/02  San Diego
  • マルチベンダ環境における放射線治療情報統合・照合システムの構築  [Not invited]
    鈴木隆介, 安田耕一, 藤田勝久, 辻真太郎, 宮崎智夫, 石川正純, 宮本直樹, 望月健太, 清水伸一, 白土博樹
    日本放射線腫瘍学会  2011/11  神戸
  • 複数体内マーカを利用した腫瘍の呼吸性運動の詳細解析とゲーティング照射の有用性の検討  [Not invited]
    大友可奈子, 宮本直樹, 石川正純, Kenneth Sutherland, 鈴木隆介, 松浦妙子, 鬼丸力也, 清水伸一, 梅垣菊男, 白土博樹
    日本放射線腫瘍学会  2011/11  神戸
  • 線量分布検証における誤差の要因と判定基準に関する考察  [Not invited]
    石川正純, Kenneth Sutherland, 峯村俊行, 棚邊哲史, 遠山尚紀, 成田雄一郎, 西尾禎治, 宮本直樹, 鈴木隆介, 石倉聡
    日本放射線腫瘍学会  2011/11  神戸
  • Notable achievements and future vision of the real-time tumor-tracking radiotherapy system  [Invited]
    Naoki Miyamoto
    6-th JKMP 11-th AOCMP  2011/09  Fukuoka
  • Respiratory motion of lung tumor determined by trajectory data of multiple fiducial markers in real-time tumor-tracking radiotherapy  [Not invited]
    Naoki Miyamoto, Kanako Otomo, Kenneth Sutherland, Ryusuke Suzuki, Taeko Matsuura, Chie Toramatsu, Seishin Tako, Hideaki Nihongi, Rumiko Kinoshita, Shinichi Shimizu, Rikiya Onimaru, Masayori Ishikawa, Kikuo Umegaki, Hiroki Shirato
    6-th JKMP 11-th AOCMP  2011/09  Fukuoka
  • The initial evaluation of irradiation time and motion dose errors in Real-time Tumor-Tracking Proton Beam Therapy  [Not invited]
    Taeko Matsuura, Naoki Miyamoto, Kenneth Sutherland, Chie Toramatsu, Seishin Tako, Hideaki Nihongi, Shinichi Shimizu, Rumiko Kinoshita, Rikiya Onimaru, Yusuke Fujii, Taisuke Takayanagi, Rintaro Fujimoto, Yoshihiko Nagamine, Kikuo Umegaki, Hiroki Shirato
    6-th JKMP 11-th AOCMP  2011/09  Fukuoka
  • A feasibility study on molecular-guided radiotherapy using a parallel plane PET  [Not invited]
    Masayori Ishikawa, Satoshi Yamaguchi, Satoshi Tanabe, Kenneth Sutherland, Naoki Miyamoto, Ryusuke Suzuki, Hiroki Shirato
    6-th JKMP 11-th AOCMP  2011/09  Fukuoka
  • 陽子線治療計画装置とX線治療計画の環境構築  [Not invited]
    清水伸一, 木下留美子, 鬼丸力也, 白土博樹, 二本木英明, 寅松千枝, 松浦妙子, 高尾聖心, 宮本直樹, 梅垣菊男
    第8回日本粒子線治療臨床研究会  2011/09  群馬
  • 分子追跡陽子線治療装置の開発  [Not invited]
    梅垣菊男, 寅松千枝, 松浦妙子, 高尾聖心, 二本木英明, 宮本直樹, 清水伸一, 木下留美子, 鬼丸力也, 白土博樹
    第8回日本粒子線治療臨床研究会  2011/09  群馬
  • 複数マーカを利用したゲーティング照射における照射効率に関する検討  [Not invited]
    大友可奈子, 宮本直樹, 石川正純, Kenneth Sutherland, 鈴木隆介, Gerard Bengua, 松浦妙子, 鬼丸力也, 清水伸一, 白土博樹
    第101回日本医学物理学会  2011/05  Web
  • 陽子線スキャニングビームにおける偏向磁場による線量分布の形状変化に関する考察  [Not invited]
    前田憲一郎, Kenneth Sutherland, 松浦妙子, 石川正純, 清水伸一, 鬼丸力也, 木下留美子, Gerard Bengua, 宮本直樹, 鈴木隆介, 白土博樹
    第101回日本医学物理学会  2011/05  Web
  • 対向型PET装置を用いた3次元分子追跡装置の基礎検討  [Not invited]
    右近直之, 石川正純, 棚邊哲史, 山口哲, 宮本直樹, Gerard Bengua, 志賀哲, 玉木長良, 白土博樹
    第101回日本医学物理学会  2011/05  Web
  • スポット陽子線照射における体内マーカーの問題点〜前立腺位置合わせと飛程変化に関する考察〜  [Not invited]
    山中琢, 松浦妙子, 石川正純, Kenneth Sutherland, 清水伸一, 鬼丸力也, 木下留美子, Gerard Bengua, 宮本直樹, 鈴木隆介, 白土博樹
    第101回日本医学物理学会  2011/05  Web
  • Real-time tumor-tracking, spot scanning proton beam therapy  [Not invited]
    Shirato H, Shimizu S, Onimaru R, Kinoshita R, Umegaki K, Matsuura T, Miyamoto N, Ishikawa M, Hiramoto K, Nakamura
    PTCOG 50  2011/05  Philadelphia
  • Dose distribution analysis of moving target irradiated by proton spot scanning combined with gating technique  [Not invited]
    Yusuke Fujii, Toru Umekawa, Rintaro Fujimoto, Yoshihiko Nagamine, Masumi Umezawa, Kazuo Hiramoto, Hiroshi Akiyama, Naoki Miyamoto, Taeko Matsuura, Kikuo Umegaki, Hiroki Shirato
    PTCOG 50  2011/05  Philadelphia
  • Improvement of Tracking Accuracy and Stability with Utilizing a Color Image Intensifier in Real-time Tumor-tracking Radiotherapy System  [Not invited]
    Naoki Miyamoto, Masayori Ishikawa, Kenneth Sutherland, Gerard Bengua, Ryusuke Suzuki, Hiroki Shirato
    52nd ASTRO Annual Meeting  2010/10  San Diego
  • Conceptual Design of PET-linac System for Molecular-guided Radiotherapy  [Not invited]
    Masayori Ishikawa, Kenneth Sutherland, Gerard Bengua, Ryusuke Suzuki, Naoki Miyamoto, Norio Katoh, Shinichi Shimizu, Rikiya Onimaru, Hidefumi Aoyama, Hiroki Shirato
    52nd ASTRO Annual Meeting  2010/10  San Diego
  • Feasibility Study on Molecular-imaging Based Tracking System for Lung Cancer Treatment  [Not invited]
    Satoshi Tanabe, Masayori Ishikawa, Kenneth Sutherland, Gerard Bengua, Ryusuke Suzuki, Naoki Miyamoto, Norio Katoh, Shinichi Shimizu, Rikiya Onimaru, Hidefumi Aoyama, Hiroki Shirato
    52nd ASTRO Annual Meeting  2010/10  San Diego
  • 動体追跡放射線治療における画像処理を応用したマーカ追跡精度の向上  [Not invited]
    宮本直樹, 石川正純, Kenneth Sutherland、Gerard Bengua, 鈴木隆介, 白土博樹
    第100 回日本医学物理学会  2010/09  東京
  • 動体追跡データに基づく腫瘍および周辺臓器のDVH 線量解析-JCOG0702 プロトコルへの適用-  [Not invited]
    石川正純, 宮本直樹, Kenneth Sutherland、Gerard Bengua, 鈴木隆介, 白土博樹
    第100 回日本医学物理学会  2010/09  東京
  • 新規ライナック導入に伴うコミッショニング手順に関する報告  [Not invited]
    鈴木隆介, 石川正純, 宮本直樹, Gerard Bengua, Kenneth Sutherland, 白土博樹
    第99 回日本医学物理学会  2010/04  横浜
  • 光ファイバ線量計を用いた高エネルギーγ線線量測定におけるチェレンコフ光除去方法の検討  [Not invited]
    太田真緒, 石川正純, 江口奈弥帆, Gerard Bengua, 鈴木隆介, 宮本直樹, Kenneth Sutherland, 白土博樹
    第99 回日本医学物理学会  2010/04  横浜
  • Basics of real-time tumor tracking radiothrepy (RTRT) and development of a next generation RTRT  [Invited]
    Naoki Miyamoto, Masayori Ishikawa, Kenneth Sutherland, Bengua Gerard, Ryusuke Suzuki, Shinichi Shimizu, Rikiya Onimaru, Hidefumi Aoyama, Hiroki Shirato
    5th International Symposium on Medical, Bio- and Nano-Electronics  2010/02  Sendai
  • Can the real-time tumor-tracking radiotherapy give the planned dose to the tumor? DVH analysis based on measured real-time tracking data  [Not invited]
    Masayori Ishikawa, Kenneth Sutherland, Gerard Bengua, Ryusuke Suzuki, Naoki Miyamoto, Norio Katoh, Shinichi Shimizu, Rikiya Onimaru, Hidefumi Aoyama, Hiroki Shirato
    51st ASTRO Annual Meeting  2009/10  Chicago
  • 動体追跡装置を用いた肺定位照射時の投与線量解析―動体追跡データに基づくDVH解析―  [Not invited]
    石川正純, Kenneth Sutherland, 宮本直樹, Gerard Bengua, 清水伸一, 青山英史, 鬼丸力也, 木村傑, 白土博樹
    日本放射線腫瘍学会第22回学術大会  2009/09
  • 動体追跡放射線治療におけるX線透視条件の最適化  [Not invited]
    宮本直樹, 石川正純, Kenneth Sutherland、Gerard Bengua, 清水伸一, 青山英史, 鬼丸力也, 木村傑, 白土博樹
    第98 回日本医学物理学会  2009/09
  • 動体追跡装置におけるコントラスト-ノイズ比(CNR)の測定方法の検討  [Not invited]
    木村傑, 宮本直樹, 石川正純, Kenneth Sutherland、Gerard Bengua, 清水伸一, 青山英史, 鬼丸力也, 白土博樹
    第98 回日本医学物理学会  2009/09
  • 体内臓器同期照射を目的とした次世代動体追跡装置の開発〜複数マーカ追跡への挑戦〜  [Not invited]
    石川正純, Kenneth Sutherland, 宮本直樹, Gerard Bengua, 清水伸一, 青山英史, 鬼丸力也, 木村傑, 白土博樹
    第97回日本医学物理学会学術大会  2009/04  横浜
  • 体内臓器同期照射を目的とした次世代動体追跡装置の開発〜透視画像の歪みと位置計算誤差〜  [Not invited]
    宮本直樹, 石川正純, Kenneth Sutherland、Gerard Bengua, 清水伸一, 青山英史, 鬼丸力也, 木村傑, 白土博樹
    第97回日本医学物理学会学術大会  2009/04  横浜
  • 体内臓器同期照射を目的とした次世代動体追跡装置の開発〜デジタル画像機器としての定量的評価〜  [Not invited]
    木村傑, 石川正純, Kenneth Sutherland, 宮本直樹, Gerard Bengua, 鈴木隆介, 清水伸一, 青山英史, 鬼丸力也, 白土博樹
    第97回日本医学物理学会学術大会  2009/04  横浜
  • 対向型PET装置を用いた患者位置確認システムの開発−GEANT4基礎シミュレーション−  [Not invited]
    山口哲, 石川正純, 棚邊哲史, Gerard Bengua, Kenneth Sutherland, 宮本直樹, 鈴木隆介, 青山英史, 武島嗣英, 白土 博樹
    第97回日本医学物理学会学術大会  2009/04  横浜
  • 対向型PET装置を用いた分子イメージング動体追跡装置の開発〜18F点線源を用いた追跡精度の検証〜  [Not invited]
    棚邊哲史, 石川正純, 山口哲, 武島嗣英, 鈴木隆介, 宮本直樹, 加藤徳雄, 清水伸一, 鬼丸力也, 白土博樹
    第97回日本医学物理学会学術大会  2009/04  横浜
  • 次世代動体追跡装置の開発〜位置計算誤差の評価〜  [Not invited]
    宮本直樹, 石川正純, Gerard Bengua, 鈴木隆介, 木村傑, Kenneth Sutherland, 清水伸一, 青山英史, 鬼丸力也, 白土博樹
    第19回日本高精度放射線外部照射研究会  2009/01  名古屋
  • 小型加速器中性子源を用いた中性子共鳴吸収断層撮像  [Not invited]
    加美山隆, 宮本直樹, 富岡智, 小崎完
    日本原子力学会秋の大会  2008  高知
  • Epithermal neutron tomography with time-of-flight technique  [Not invited]
    Takashi Kamiyama, Hirotaka Sato, Naoki Miyamoto, Hirokatsu Iwasa, Yoshiaki Kiyanagi, Susumu Ikeda
    IEEE Nuclear Science Symposium and Medical Imaging Conference  2007/10  Honolulu
  • 中性子共鳴吸収分光法と計算機断層撮像法を利用した核種分布の非破壊分析  [Not invited]
    宮本直樹, 小崎完, 富岡智, 加美山隆
    日本原子力学会秋の大会  2007  北九州
  • 小型加速器を利用した中性子共鳴吸収CTによる核種分布の非破壊分析  [Not invited]
    宮本直樹, 小崎完, 富岡智, 加美山隆
    日本非破壊検査協会秋季大会,  2007  札幌
  • Study of Neutron Tomography using Neutron Resonance Absorption  [Not invited]
    Takashi Kamiyama, Hirotaka Sato, Naoki Miyamoto, Hirokatsu Iwasa, Yoshiaki Kiyanagi, Susumu Ikeda
    The 18th Meeting of the International Collaboration on Advanced Neutron Sources  2007  Beijing
  • 光変調材料を用いた赤外線ホログラフィー  [Not invited]
    宮本直樹, 西山修輔, 富岡智, 榎戸武揚
    第6 回核融合エネルギー連合講演会  2006  富山
  • 中赤外光計測を目的とした熱吸収型可視位相変調素子の空間分解能  [Not invited]
    富岡智, 宮本直樹, 西山修輔, 榎戸武揚
    第6 回核融合エネルギー連合講演会  2006  富山
  • ニトロアニソールを用いた赤外線ホログラフィによる画像再生と計測への応用  [Not invited]
    宮本直樹, 西山修輔, 富岡智, 榎戸武揚
    高速度撮影とフォトニクスに関する総合シンポジウム  2005  市ヶ谷
  • Infrared phase-shifting interferometer using the nitroanisole as a two-dimensional detector  [Not invited]
    Naoki Miyamoto, Shusuke Nisiyama, Satoshi Tomioka, Takeaki Enoto
    SPIE International Symposium on Optomechatronic Technologies, Optomechatronic Sensors and Instrumentation  2005  Sapporo
  • ニトロアニソールを用いた赤外位相情報の可視化  [Not invited]
    宮本直樹, 西山修輔, 富岡智, 榎戸武揚
    第65 回応用物理学会学術講演会  2004  仙台

MISC

  • 頭蓋底腫瘍術後に強度変調放射線治療を行った2例
    森 崇, 宮本 直樹, 鈴木 隆介, 鬼丸 力也, 白土 博樹  Japanese Journal of Radiology  35-  (Suppl.)  4  -4  2017/02  [Not refereed][Not invited]
  • 食道IMRTにおけるintra-fractional organ motionの影響
    田村 弘詞, 宮本 直樹, 鈴木 隆介, 堀田 賢治, 藤田 勝久, 井上 哲也  日本放射線技術学会雑誌  72-  (9)  873  -874  2016/09  [Not refereed][Not invited]
  • 宮本 直樹, 石川 正純, 井上 哲也, 加藤 徳雄, 清水 伸一, 鬼丸 力也, 白土 博樹  臨床放射線  61-  (2)  293  -302  2016/02  [Not refereed][Not invited]
  • 椎体IMRTとその精度に関する研究
    安田 耕一, 清水 伸一, 橋本 孝之, Sutherland Ken, 白土 博樹, 土屋 和彦, 加藤 徳雄, 鬼丸 力也, 木下 留美子, 井上 哲也, 西岡 健太郎, 西川 由記子, 森 崇, 原田 慶一, 原田 八重, 鈴木 隆介, 寅松 千枝, 松浦 妙子, 高尾 聖心, 宮本 直樹, 伊藤 陽一  Japanese Journal of Radiology  34-  (Suppl.)  5  -5  2016/02  [Not refereed][Not invited]
  • 照射中と4DCT撮像時の肺内マーカー移動の比較
    原田 慶一, 加藤 徳雄, 井上 哲也, 鬼丸 力也, 清水 伸一, 白土 博樹, 鈴木 隆介, 宮本 直樹, 石川 正純  Japanese Journal of Radiology  34-  (Suppl.)  10  -10  2016/02  [Not refereed][Not invited]
  • 新規動体追跡技術により可能になる3D imagingによる自由行動マウスの全身の遺伝子発現追跡定量法の開発
    浜田 俊幸, 石川 正純, Sutherland Kenneth, 宮本 直樹, 白土 博樹, 本間 さと, 本間 研一  バイオイメージング  24-  (2)  114  -114  2015/09  [Not refereed][Not invited]
  • 新規4D imagingによる自由行動マウスの全身の時計遺伝子発現制御機構の解析
    浜田 俊幸, Sutherland Kenneth, 石川 正純, 宮本 直樹, 本間 さと, 白土 博樹, 本間 研一  日本薬学会年会要旨集  135年会-  (2)  290  -290  2015/03  [Not refereed][Not invited]
  • 4DCTを用いた肺内マーカー移動の解析
    加藤 徳雄, 原田 慶一, 鈴木 隆介, 井上 哲也, 鬼丸 力也, 清水 伸一, 宮本 直樹, 白土 博樹  Japanese Journal of Radiology  33-  (Suppl.)  5  -5  2015/02  [Not refereed][Not invited]
  • 【放射線治療活用BOOK 2014】 (DIVISION-3)これからの放射線治療の展望 最新の動体追跡放射線治療装置
    宮本 直樹, 石川 正純, 松浦 妙子, 井上 哲也, 加藤 徳雄, 清水 伸一, 鬼丸 力也, 梅垣 菊男, 白土 博樹  Rad Fan  12-  (15)  75  -77  2014/12  [Not refereed][Not invited]
     
    動体追跡法は、日本が世界に先駆けて実現してきた治療法であり、多くの実績を有する。本稿では、最新の迎撃照射型動体追跡装置として、島津製作所からリリースされたX線治療用動体追跡装置「SyncTraX」、日立製作所からリリースされた動体追跡陽子線スポットスキャニングシステム「PROBEAT-RT」について、その特徴と利点を紹介する。(著者抄録)
  • 新動体追跡システムにおけるゲート照射時のビーム特性の評価
    田村 弘詞, 宮本 直樹, 藤田 勝久, 堀田 賢治, 斉藤 英一  日本放射線技術学会雑誌  70-  (9)  973  -973  2014/09  [Not refereed][Not invited]

Industrial Property Rights

Awards & Honors

  • 2017/04 公益社団法人 発明協会 恩賜発明賞
     動体追跡粒子線がん治療装置の発明 
    受賞者: 藤井祐介;梅川徹;梅澤真澄;白土博樹;梅垣菊男;宮本直樹;松浦妙子
  • 2012/09 医学物理学会 Outstanding Research Award
     Real-time tumor-tracking system with single fluoroscopic imaging 
    受賞者: Naoki Miyamoto;Masayori Ishikawa;Kenneth Sutherland;Ryusuke Suzuki;Taeko Matsuura;Chie Toramatsu;Seishin Tako;Hideaki Nihongi;Shinichi Shimizu;Kikuo Umegaki;Hiroki Shirato
  • 2011/10 Japanese Society of Medical Physics Outstanding Poster Award
     Respiratory motion of lung tumor determined by trajectory data of multiple fiducial markers in real-time tumor-tracking radiotherapy 
    受賞者: Naoki Miyamoto;Kanako Otomo;Kenneth Sutherland;Ryusuke Suzuki;Taeko Matsuura;Chie Toramatsu;Seishin Tako;Hideaki Nihongi;Rumiko Kinoshita;Shinichi Shimizu;Rikiya Onimaru;Masayori Ishikawa;Kikuo Umegaki;Hiroki Shirato
  • 2007/10 Japanese Society for Non-Destructive Inspection Young Scientists Award
     Non-destructive analysis of nuclide distribution by neutron resonance absorption CT utilizing a small pulsed neutron source 
    受賞者: Naoki Miyamoto;Tamotsu Kozaki;Satoshi Tomioka;Takashi Kamiyama

Research Grants & Projects

  • 次世代の体幹部定位放射線治療を実現する動体追跡回転照射の基盤技術開発
    文部科学省:科学研究費補助金(基盤研究(B))
    Date (from‐to) : 2017/04 -2020/03 
    Author : 宮本 直樹
  • CBCT画像を用いた線量評価に基づく治療効果誘導放射線治療技術の開発
    文部科学省:科学研究費補助金(基盤研究(C))
    Date (from‐to) : 2016/04 -2019/03 
    Author : 高尾聖心
  • 標的の非均質性と動きを考慮したロバストな陽子線スキャニング治療技術の開発
    文部科学省:科学研究費補助金(基盤研究(B))
    Date (from‐to) : 2016/04 -2019/03 
    Author : 梅垣菊男
  • 4D-CBCTと治療計画CTの容積マッチング法による4D-IGRTの試み
    文部科学省:科学研究費補助金(基盤研究(B))
    Date (from‐to) : 2015/04 -2018/03 
    Author : 清水伸一
  • 四次元コンピュータトモグラフィーにおける不完全データに対する重みつき再構成手法
    文部科学省:科学研究費補助金(基盤研究(C))
    Date (from‐to) : 2015/04 -2018/03 
    Author : 富岡智
  • 待ち伏せ照射の高精度化を目的とした体内呼吸運動に基づく呼吸位相モニタの開発
    文部科学省:科学研究費補助金(基盤研究(C))
    Date (from‐to) : 2014/04 -2017/03 
    Author : 宮本 直樹
  • 2軸X線を用いた4D−CBCTの撮像方法構築による相互作用放射線治療の試み
    文部科学省:科学研究費補助金(基盤研究(C))
    Date (from‐to) : 2012/04 -2014/03 
    Author : 清水 伸一
     
    平成24年度は、2軸X線を用いた4次元コーンビームCT(4D-CBCT)撮像方法構築のため、北海道大学にて保有する動体追跡装置を用いて放射線治療を行ったデータのログを用いて、4D-CBCT の元画像 を撮像する際のガントリー回転速度と画像取得位置、取得可能な画像データ数、4D-CBCT 画像を作成する際に得 られる呼吸位相数のシミュレーションを行った。その結果を基に、2軸X線撮像系を実際に用いてファントム実験およびCBCT画像を計算・取得するための元画像の撮像を行った。これら元画像は、次年度以降の研究で予定している4D-CBCT画像取得のためのシミュレーション、ファントムの考案、作成および演算法最適化に用いる予定である。本研究の実行可能性について事前検討のために作成し、計算を行った基本的なシミュレーションソフトウエアの結果を基に、CBCT撮像のソフトウエアの本作成に着手した。このソフトウエアの本作成ならびに動体追跡放射線治療で取得された実際の治療ログを用いることにより、陽子線治療装置ガントリー上で取得可能な4D-CBCT 元画像の必要撮影条件の検討を行った。知的財産申請の都合上本研究に直接関与する学会・論文発表は行えなかったが、関連する基礎研究成果として骨盤部CBCT画像での臓器輪郭描出に関する検討.としてコーンビームCTに関係する研究内容を日本医学放射線学会北日本地方会にて学会発表を行った。
  • 動体追跡放射線治療への応用を目的とした一方向X線透視による呼吸モニタの開発
    文部科学省:科学研究費補助金(若手研究(B))
    Date (from‐to) : 2012 -2013 
    Author : 宮本 直樹
     
    呼吸などにより体内で動く腫瘍に対する放射線治療では、その動きを考慮した治療放射線の投与を考える必要がある。現在では、2方向から腫瘍周辺をX線透視し、腫瘍近傍に留置された体内マーカーの3次元位置を把握することで、所定の位置でのみ照射をおこなう呼吸同期放射線治療が有効な手法の1つとして臨床応用されている。しかし、2組のX線透視装置を用いるシステムでは、装置の設置スペースや導入時のコスト等が問題の1つとなる。本研究では、より汎用的な呼吸同期放射線治療を実現するために、1組のX線透視装置のみを用いて、2組のX線透視装置を用いるシステムと同様に、体内マーカーの3次元位置を計測することが可能なシステムを開発することを目的としている。平成24年度は、申請時に計画していた(1)X線透視装置の配置の検討と(2)測定精度解析を実施し、提案手法の実現可能性を評価した。(1)に関しては、X線発生装置と検出器の位置関係に加えて、検出器での体内マーカー検出精度が、3次元位置の計測精度に大きく影響することがわかったが、これまでに開発したサブピクセル精度でのテンプレートパターンマッチング技術により、体内マーカーの3次元位置測定精度±2mmを実現できることを示した。また、(2)については、実際の放射線治療に用いられた体内マーカー位置および呼吸運動情報を利用し、測定精度評価を解析的に実施した。これらの結果を第104回医学物理学会学術大会(2012年9月13-15日、つくば)にて報告し、優秀研究賞を受賞することができた。
  • Development of 4-dimensional Cone Beam CT for precise IGRT
    Association for Nuclear Technology in Medicine:Research Grant for Nuclear Technology in Medicine
    Date (from‐to) : 2011/04 -2012/03 
    Author : Naoki Miyamoto
  • Development of real-time tumor-tracking radiotherapy system with utilizing color X-ray image intensifier
    Ministry of Education, Culture, Sports, Science and Technology:Grants-in-Aid for Scientific Research(若手研究(B))
    Date (from‐to) : 2010/04 -2012/03 
    Author : Naoki MIYAMOTO
     
    カラーX線画像の各RGB成分に対し、それぞれエッジ強調処理と差分処理を施した画像を加算することにより、追跡すべき体内マーカのエッジ部分のみをクリアに抽出する方法を開発し、マーカの誤認識やロストを低減できることを示した。また、マーカの動きに応じて積算エリアを更新する画像処理アルゴリズムを開発し、低線量透視における認識位置の精度と認識スコアの向上が可能であることを示した。
  • Pattern projection system for patient setup in radiation therapy
    Hokkaido University:Research Grant for Young Scientists
    Date (from‐to) : 2009/04 -2010/03 
    Author : Naoki Miyamoto

Educational Activities

Teaching Experience

  • 総合医理工学研究Ⅰ
    開講年度 : 2018
    課程区分 : 修士課程
    開講学部 : 医理工学院
  • Basic Physics for Radiation Therapy
    開講年度 : 2018
    課程区分 : 修士課程
    開講学部 : 医理工学院
    キーワード : 放射線治療、放射線物理学、加速器 Radiation oncology, radiation physics, accelerators
  • 総合医理工学研究Ⅱ
    開講年度 : 2018
    課程区分 : 修士課程
    開講学部 : 医理工学院
  • Inter-Graduate School Classes(General Subject):Natural and Applied Sciences
    開講年度 : 2018
    課程区分 : 修士課程
    開講学部 : 大学院共通科目
  • 放射線治療物理学実習Ⅰ
    開講年度 : 2018
    課程区分 : 博士後期課程
    開講学部 : 医学研究科
  • Medical Physics School
    開講年度 : 2018
    課程区分 : 修士課程
    開講学部 : 医理工学院
  • 放射線治療物理学実習Ⅱ
    開講年度 : 2018
    課程区分 : 博士後期課程
    開講学部 : 医学研究科
  • Radiation Measurement in Clinical Practice
    開講年度 : 2018
    課程区分 : 修士課程
    開講学部 : 医理工学院
    キーワード : 放射線計測、放射線治療、医学物理学 radiation measurement, radiation therapy, medical physics
  • 放射線治療物理学実習Ⅲ
    開講年度 : 2018
    課程区分 : 博士後期課程
    開講学部 : 医学研究科
  • Principles of Medicine
    開講年度 : 2018
    課程区分 : 博士後期課程
    開講学部 : 医学院
    キーワード : がん 高精度放射線治療 がんプロフェッショナル養成プラン Cancer, high-precision radiation therapy, cancer professional training plan
  • 医学総論
    開講年度 : 2018
    課程区分 : 博士後期課程
    開講学部 : 医学研究科
  • Principles of Medicine
    開講年度 : 2018
    課程区分 : 博士後期課程
    開講学部 : 医学院
    キーワード : 放射線医学、放射線診断学、画像診断、インターベンショナル、放射線治療、癌、がんプロフェッショナル Radiation medicine, diagnostic radiology, imaging diagnosis, interventional radiology, radiotherapy, cancer, cancer professional
  • 先端医理工学研究Ⅰ
    開講年度 : 2018
    課程区分 : 博士後期課程
    開講学部 : 医理工学院
  • Clinical Medical Physics Training (Proton/Image-guided Radiation Therapy)
    開講年度 : 2018
    課程区分 : 博士後期課程
    開講学部 : 医理工学院
    キーワード : 放射線治療装置、位置照合装置、治療計画、CT、陽子線治療 radiotherapy device, position matching device, planning system, CT, proton treatment
  • 先端医理工学研究Ⅱ
    開講年度 : 2018
    課程区分 : 博士後期課程
    開講学部 : 医理工学院
  • Clinical Medical Physics Training (Quality Assurance)
    開講年度 : 2018
    課程区分 : 博士後期課程
    開講学部 : 医理工学院
    キーワード : 放射線防護、放射線治療装置、位置照合装置、治療計画、QA Radiation protection, exteranal beam treatment units, position matching device, treatment planning system, QA
  • Clinical Medical Physics Training (Treatment Planning)
    開講年度 : 2018
    課程区分 : 博士後期課程
    開講学部 : 医理工学院
    キーワード : 照射録、X線、電子線、小線源治療、品質管理、治療計画 Treatment record, x-ray, electron beam, proton beam, brachytherapy, quality accurance, treatment planning


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