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Hiroshi Maejima
Faculty of Health Sciences　Health Sciences　Department of Rehabilitation Science
Professor
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Last Updated :2024/05/09

Researcher Profile and Settings

Affiliation

  • Faculty of Health Sciences　Health Sciences　Department of Rehabilitation Science

Job Title

  • Professor

J-Global ID

Research Interests

  • 神経科学・ リハビリテーション・ 理学療法学・生理学一般   Neuro and Musculer Physiology Rehabilitation Physical Therapy Physiology in General   

Research Areas

  • Life sciences / Nervous system function
  • Life sciences / Physiology
  • Life sciences / Rehabilitation science
  • Life sciences / Neuroscience - general

Educational Organization

Academic & Professional Experience

  • 2014/04 - Today Hokkaido University Faculty of Health Sciences
  • 2010/04 - 2014/03 Teikyo University of Science & Technology Faculty of Medical Sciences
  • 2008/04 - 2010/03 Hiroshima University Graduate School of Health Sciences
  • 2007/04 - 2008/03 Hiroshima University Graduate School of Health Sciences
  • 2004/04 - 2008/03 Hiroshima University Institute of Health Sciences, Faculty of Medicine
  • 2000/04 - 2007/03 Hiroshima University Graduate School of Health Sciences
  • 2005/03 - 2006/03 Northwestern University Feinberg School of Medicine 研究員
  • 1999/04 - 2000/03 Hiroshima University Institute of Health Sciences, Faculty of Medicine

Education

  •        - 1999  Hiroshima University  Graduate School, Division of Medical Sciences
  •        - 1996  Hiroshima University  Faculty of Medicine

Association Memberships

  • The American Physiological Society   Society for Neuroscience   JAPANESE PHYSICAL THERAPY ASSOCIATION   JAPANESE ASSOCIATION OF PHYSICAL THERAPY FUNDAMENTALS   JAPANESE SOCIETY OF PROSTHETICS AND ORTHOTICS   THE JAPAN NEUROSCIENCE SOCIETY   PHYSIOLOGICAL SOCIETY OF JAPAN   

Research Activities

Published Papers

  • Taichi NISHIO, Takahiro INOUE, Yasuyuki TAKAMATSU, Taiga MISHIMA, Hana TAKAMURA, Kiho SOMA, Yuki KONDO, Misato OKAMURA, Ryo IKEGAMI, Hiroshi MAEJIMA
    Biomedical Research 45 (1) 1 - 11 0388-6107 2024/02/02 [Refereed]
  • Yasuyuki Takamatsu, Takahiro Inoue, Taichi Nishio, Kiho Soma, Yuki Kondo, Taiga Mishima, Hana Takamura, Misato Okamura, Hiroshi Maejima
    Neuroscience Letters 824 137670 - 137670 0304-3940 2024/02 [Refereed][Not invited]
  • Misato Okamura, Takahiro Inoue, Yasuyuki Takamatsu, Hiroshi Maejima
    Journal of Stroke and Cerebrovascular Diseases 32 (9) 107275 - 107275 1052-3057 2023/09 [Refereed]
  • Takahiro Inoue, Ryo Ikegami, Yasuyuki Takamatsu, Mamoru Fukuchi, Sanae Haga, Michitaka Ozaki, Hiroshi Maejima
    Neuroscience Letters 799 137120 - 137120 0304-3940 2023/03 [Refereed]
  • Hiroshi Maejima, Misato Okamura, Takahiro Inoue, Yasuyuki Takamatsu, Taichi Nishio, Yushan Liu
    Brain Research 1806 148286 - 148286 0006-8993 2023/02 [Refereed]
  • Takahiro Inoue, Yasuyuki Takamatsu, Taichi Nishio, Kiho Soma, Misato Okamura, Harukazu Tohyama, Hiroshi Maejima
    Neuroscience Letters 766 136344 - 136344 0304-3940 2022/01 [Refereed][Not invited]
     
    The present study aimed to examine the synergistic effects of exercise and pharmacological inhibition of the α5 subunit-containing gamma-aminobutyric acid (GABA)A receptors (α5GABAAR) on motor function recovery after intracerebral hemorrhage (ICH). Wistar rats were divided into five groups (n = 8 per group): SHAM, ICH, ICH + exercise (ICH + EX), ICH + L-655,708 (ICH + L6), and ICH + L-655,708 and exercise (ICH + L6EX) groups. ICH was induced by microinjection of a collagenase solution. The ICH + EX and ICH + L6EX groups exercised on a treadmill (12 m/min for 30 min/day). L-655,708 (0.5 mg/kg), a negative allosteric modulator of α5GABAAR, was administered intraperitoneally to the ICH + L6 and ICH + L6EX groups. Each intervention was initiated 1 week after the ICH surgery and was performed for 3 weeks, followed by tissue collection, including the motor cortex and spinal cord. At 4 weeks after ICH, significant motor recovery was found in the ICH + L6EX group compared to the ICH group. L-655,708 administration increased brain-derived neurotrophic factor (BDNF) expression in the cortex. Regarding neuroplastic changes in the spinal cord, rats in the ICH + L6EX group showed a significant increase in several neuroplastic markers: 1) BDNF, 2) growth-associated protein 43 as an axonal sprouting marker, 3) synaptophysin as a synaptic marker, and 4) Nogo-A as an axonal growth inhibitor. This study is the first to demonstrate that combined treatment with exercise and α5GABAAR inhibitor effectively promoted motor function recovery after ICH. Regarding the underlying mechanism of post-ICH recovery with the combined treatment, the present study highlights the importance of both growth and inhibitory modification of axonal sprouting in the spinal cord.
  • Takahiro Inoue, Yasuyuki Takamatsu, Misato Okamura, Hiroshi Maejima
    Brain Research 1767 147536 - 147536 0006-8993 2021/09 [Refereed]
  • Shotaro Otsuka, Harutoshi Sakakima, Akira Tani, Kazuki Nakanishi, Seiya Takada, Kosuke Norimatsu, Hiroshi Maejima, Ikuro Maruyama
    Brain Structure and Function 226 (7) 2169 - 2180 1863-2653 2021/06/10 [Refereed]
     
    Preconditioning exercise prior to stroke exerts neuroprotection, which is an endogenous strategy that leads the brain cells to express several intrinsic factors and inhibits their apoptosis. However, it is unclear how long these benefits last after exercise cessation. The aim of this study was to investigate the effects of detraining on preconditioning exercise-induced neuroprotective potential after stroke. Rats were trained using a treadmill for aerobic exercise 5 days each week for 3 weeks, and their neuroprotective effects were examined until 3 weeks after exercise cessation. Stroke was induced by 60 min of left middle cerebral artery occlusion at 3 days, 1, 2, and 3 weeks after exercise cessation. Infarct volume, neurological deficits, sensorimotor function, expression levels of brain-derived neurotrophic factor (BDNF), hypoxia-induced factor-1α (HIF-1α), glial fibrillary acidic protein (GFAP), and P2X7 receptors, and apoptosis activity were examined using immunohistochemical and western blot analyses. Preconditioning exercise significantly reduced infarct volume and ameliorated sensorimotor function after stroke, and its beneficial effects were observed until 2 weeks after exercise cessation. The expression level of BDNF in the ischemic brain was significantly upregulated at 3 days after exercise cessation; however, the expression levels of HIF-1α, GFAP, and P2X7 receptor were significantly increased until 2 weeks after exercise cessation; thereby, significant anti-apoptotic effects were lost at 3 weeks of detraining. Our findings suggest that preconditioning exercise-induced neuroprotective potential may be lost shortly after exercise cessation. Neuroprotection through intrinsic protective factors, such as BDNF and HIF-1α, may provide different neuroprotective mechanisms in a time-dependent manner during detraining.
  • Takahiro INOUE, Yasuyuki TAKAMATSU, Misato OKAMURA, Hiroki MANI, Naoya HASEGAWA, Hiroshi MAEJIMA
    Biomedical Research 42 (3) 103 - 108 0388-6107 2021/06/07 [Refereed]
  • Invivo local transranial magnetic field stimulation alters motor behavior in normal rats
    Takamatsu Y, Inoue T, Okamura M, Ikegami R, Maejima H
    Neuroiscience Letters 753 135864  2021/04 [Refereed][Not invited]
  • Mika Kitahara, Takahiro Inoue, Hiroki Mani, Yasuyuki Takamatsu, Ryo Ikegami, Harukazu Tohyama, Hiroshi Maejima
    Neuroscience letters 749 135749 - 135749 2021/02/18 [Refereed][Not invited]
     
    Exercise is recognized to increase the expression of neurotrophic genes in the hippocampus and prevent cognitive impairment. Histone deacetylase (HDAC) inhibitor acetylate histones and enhance gene transcription in epigenetic regulation. HDAC inhibitors are expected to be an efficacious pharmacological treatment for cognitive function. This study aimed to examine the effect of HDAC inhibitors and exercise on epigenetic markers and neurotrophic gene expression in the hippocampus to find a more enriched brain conditioning for cognitive function based on the synergic effects of pharmacological treatment and behavioral therapy. Thirteen-week-old male mice were divided into four groups. Intraperitoneal administration of an HDAC inhibitor (1.2 g/kg sodium butyrate, NaB) and treadmill exercise (approximately 10 m/min for 60 min) were performed 5 days a week for 4 weeks. NaB administration increased the expression of an immediate-early gene, a neurotrophin, and a neurotrophin receptor in the hippocampus. These results indicate that HDAC inhibition could present an enriched platform for neuronal plasticity in the hippocampus and cognitive function. The novel object recognition test showed that NaB administration increased the score. Notably, the step-through passive avoidance test showed improved learning and memory in the presence of exercise and exercise, indicating that the mice acquired fear memory, specifically in the presence of NaB administration plus exercise. This study found that repetitive administration of HDAC inhibitors improved cognitive function and HDAC inhibitor administration plus exercise has a synergic effect on learning and memory, accompanying the enhancement of crucial gene transcriptions for neuronal plasticity in the hippocampus.
  • Misato Okamura, Takahiro Inoue, Yasuyuki Takamatsu, Hiroshi Maejima
    Journal of Stroke and Cerebrovascular Diseases 29 (12) 105316 - 105316 1052-3057 2020/12 [Refereed][Not invited]
  • Hiroshi Maejima, Mika Kitahara, Yasuyuki Takamatsu, Hiroki Mani, Takahiro Inoue
    Brain Research 147191 - 147191 0006-8993 2020/11 [Refereed][Not invited]
     
    The objective of this study was to examine the effect of epigenetic treatment using an histone deacetylases (HDAC) inhibitor in addition to aerobic exercise on the epigenetic markers and neurotrophic gene expressions in the motor cortex, to find a more enriched brain pre-conditioning for motor learning in neurorehabilitation. ICR mice were divided into four groups based on two factors: HDAC inhibition and exercise. Intraperitoneal administration of an HDAC inhibitor (1.2 g/kg sodium butyrate, NaB) and treadmill exercise (approximately at 10 m/min for 60 min) were conducted five days a week for four weeks. NaB administration inhibited total HDAC activity and enhanced acetylation level of histones specifically in histone H4, accompanying the increase of transcription levels of immediate-early genes (IEGs) (c-fos and Arc) and neurotrophins (BDNF and NT-4) crucial for neuroplasticity in the motor cortex. However, exercise enhanced HDAC activity and acetylation level of histone H4 and H3 without the modification of transcription levels. In addition, there were no synergic effects between HDAC inhibition and the exercise regime on the gene expressions. This study showed that HDAC inhibition could present more enriched condition for neuroplasticity to the motor cortex. However, exercise-induced neurotrophic gene expressions could depend on exercise regimen based on the intensity, the term etc. Therefore, this study has a novelty suggesting that pharmacological HDAC inhibition could be an alternative potent approach to present a neuronal platform with enriched neuroplasticity for motor learning and motor recovery, however, an appropriate exercise regimen is expected in this approach.
  • Takahiro Inoue, Misato Okamura, Mika Kitahara, Yasuyuki Takamatsu, Harutoshi Sakakima, Hiroshi Maejima
    Neuroscience 430 12 - 24 2020/01/23 [Refereed][Not invited]
     
    OBJECTIVES: The objective of this study was to examine the interactive effects of exercise and low-level inhibition of GABAA receptors on the recovery of motor function and BDNF expression in the primary motor cortex (M1) of a stroke rat model. METHODS: Male Sprague-Dawley rats were divided into five groups: sham (SHAM), control (CON), exercise (EX), bicuculline (BIC), and bicuculline plus exercise (BICEX) groups. All rats, except those in the SHAM group, underwent middle cerebral artery occlusion (MCAO) surgery to induce an ischemic stroke. GABAA receptor antagonist, bicuculline (0.25 mg/kg, i.p.), was administered to the BIC and BICEX groups. The EX and BICEX groups exercised on a treadmill (11 m/min for 30 min). Each intervention started 3 days after the MCAO surgery and was carried out every day for 2 weeks. Following the intervention, bilateral M1 BDNF mRNA and protein expression levels were assessed using qRT-PCR and ELISA. RESULTS: Marginal recovery was found in the EX and BIC groups, whereas motor function recovery was enhanced with exercise in the presence of BIC administration specifically in the BICEX group. Furthermore, BDNF protein level in the ipsilateral M1 was significantly higher in the BICEX group than in other groups. CONCLUSIONS: This study indicated that exercise combined with low-level inhibition of GABAA receptors after stroke could facilitate the recovery of motor function accompanied by BDNF upregulation in the ipsilateral M1. Therefore, this study provides a novel insight of pharmacological neuromodulation into stroke rehabilitation.
  • Xiang Li, Takahiro Inoue, Masataka Hayashi, Hiroshi Maejima
    Neuroscience letters 706 176 - 181 2019/07/27 [Refereed][Not invited]
     
    Exercise increases the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus and beneficially contributes to cognitive function and is accompanied by epigenetic changes. Specifically, the activity levels of histone acetyltransferases (HATs) and histone deacetylases (HDACs) regulate histone acetylation and modulate gene transcription. The objective of the present study was to assess the effect of an exercise regimen over a long period on the expression of BDNF, tropomyosin receptor kinase B (TrkB) and p75, and the activity of HATs and HDACs in the degenerative hippocampus. We used senescence-accelerated mice (SAM), and specifically, 3-month-old SAM resistant 1 (SAMR1) and SAM prone 8 (SAMP8) strains. Mice were distributed into four groups based on accelerated senescence and exercise status. Mice in the exercise groups exercised on a treadmill for 45 min a day, 3 days a week, for 6 months. Exercise significantly increased BDNF expression and decreased the expression of p75 in both SAMR1 and SAMP8. In addition, aging decreased HAT activity, whereas exercise decreased HDAC activity and increased the activity ratio of HAT to HDAC (HAT/HDAC). Therefore, the present study revealed that despite accelerated senescence, exercise up-regulated the expression of BDNF along with decreased the expression of p75, a receptor involved in apoptotic signaling. Furthermore, exercise increased HAT/HDAC, which might beneficially contribute to the transcriptional regulation for degenerative changes in the hippocampus.
  • Hiroshi Maejima, Takahiro Inoue, Yasuyuki Takamatsu
    Physical therapy research 22 (1) 38 - 43 2019 [Refereed][Not invited]
     
    Exercise is a primary therapeutic regimen in physical therapy to rehabilitate the motor function of patients with central nervous system (CNS) disorders such as cerebrovascular accident (CVA). Furthermore, exercise positively contributes to cognitive function related to neuroplasticity and neuroprotection in the hippocampus. Neurotrophins play a crucial role in neuroplasticity, neurogenesis, and neuroprotection in the CNS. Exercise enhances the expression of neurotrophins in the brain. Thus, novel regimens for kinesiotherapy in CNS disorders to further enhance exercise-induced expression are expected. In this review, we described three novel regimens for kinesiotherapy in CNS disorders based on the interaction between exercise and pharmacological treatment with the idea of "inhibition of inhibition" in the CNS.
  • Hiroshi Maejima, Shuta Ninuma, Akane Okuda, Takahiro Inoue, Masataka Hayashi
    Neuroscience letters 685 18 - 23 2018/10/15 [Refereed][Not invited]
     
    Aerobic exercise is known to increase expression of brain-derived neurotrophic factor (BDNF) in the hippocampus and to improve cognitive function. The inhibition of GABAergic synapses enhances hippocampal plasticity as well as learning and memory. The objective of the present study was to examine the interactive effect of low-level GABAA receptor inhibition and exercise on behavior tests (cognitive function and locomotor activity), expression of BDNF and epigenetic regulations including the activity levels of histone acetyltransferases (HATs) and histone deacetylases (HDACs) in the hippocampus. ICR mice were divided into two groups: those who did not participate in exercise and those who participated in exercise. Each group was subdivided into two other groups: the one who received vehicle and the one who received GABAA receptor antagonist, bicucullin. We administered saline or bicuculline intraperitoneally to the mice at a non-epileptic dose of 0.25 mg/kg, whereas the mice were exercised on a treadmill for approximately 1 h a day, 5 days a week for 4 weeks. Novel-object recognition test and locomotor activity were assessed at a rest day approximately 4 days before the euthanasia. The mice were euthanized 4 h after the last exercise session. Aerobic exercise for 4 weeks increased mRNA and protein expression of BDNF in the hippocampus, accompanied by enhanced HAT activity. Alternatively, bicuculline administration increased HDAC activity in the hippocampus. Furthermore, exercise in the presence of bicuculline administration increased locomotor activity, indicating that exercise combined with low-level GABAA receptor inhibition potentiated the activity of the mice. Altogether, the present study suggested that exercise beneficially contributes to neuroprotection in the hippocampus accompanied by the up-regulation of BDNF expression and epigenetic regulation, whereas the chronic inhibition of GABAA receptor potentiates exercise-induced behavioral activity.
  • Hiroshi Maejima, Naohiko Kanemura, Takanori Kokubun, Kenji Murata, Kiyomi Takayanagi
    Neuroscience letters 665 67 - 73 2018/02/05 [Refereed][Not invited]
     
    Aerobic exercise is known to increase expression of neurotrophins, particularly brain-derived neurotrophic factor (BDNF), in the hippocampus and to improve cognitive function. Exercise exerts neuroprotective effects in the hippocampus by inducing epigenetic changes, which play crucial roles in aging and neurodegenerative diseases. Specifically, the activity levels of histone acetyltransferases (HATs) and histone deacetylases (HDACs) regulate histone acetylation and modulate gene transcription. The objective of the present study was to assess the interactive effects of exercise and aging on cognitive function, expression of neurotrophins (BDNF and neurotrophin-4) and their receptors (tyrosine receptor kinase B and p75), and epigenetic regulations, including the activity of HATs and HADCs in the hippocampus. We used the senescence-accelerated mouse (SAM) model, specifically 13-month-old SAM resistant 1(SAMR1) and SAM prone 1 (SAMP1) lines. Mice were distributed into four groups based on accelerated senescence and exercise status. Mice in the exercise groups exercised on a treadmill for approximately 60min a day, 5days a week. Aerobic exercise for 4 weeks improved cognitive function, accompanied by an increase in BDNF expression and a decrease in p75 transcription in both SAMR1 and SAMP1. In addition, the exercise regimen activated both HAT and HDAC in the hippocampus. Therefore, the present study reveals that despite accelerated senescence, long-term exercise improved cognitive function, upregulated the expression of BDNF, and downregulated p75, a receptor involved in apoptotic signaling. Furthermore, long-term exercise enhanced activity of both HAT and HDAC, which may contribute to the transcriptional regulation underlying the improvement of cognitive function.
  • Takahiro Inoue, Shuta Ninuma, Masataka Hayashi, Akane Okuda, Tadayoshi Asaka, Hiroshi Maejima
    Neurological research 40 (1) 18 - 25 2018/01 [Refereed][Not invited]
     
    Objectives Brain-derived neurotrophic factor (BDNF) plays important roles in neuroplasticity in the brain. The objective of this study was to examine the effects of long-term exercise combined with low-level inhibition of GABAergic synapses on motor control and the expression of BDNF in the motor-related cortex. Methods ICR mice were divided into four groups based on the factors exercise and GABAA receptor inhibition. We administered the GABAA receptor antagonist bicuculline intraperitoneally (0.25 mg/kg). Mice exercised on a treadmill 5 days/week for 4 weeks. Following behavioral tests, BDNF expression in the motor cortex and cerebellar cortex was assayed using RT-PCR and ELISA. Results Exercise increased BDNF protein in the motor cortex and improved motor coordination in the rotarod test either in the presence or absence of bicuculline. BDNF mRNA expression in the motor cortex and muscle coordination in the wire hang test decreased after administration of bicuculline, whereas bicuculline administration increased mRNA and protein expression of BDNF in the cerebellum. Discussion The present study revealed that long-term exercise increased BDNF expression in the motor cortex and facilitated a transfer of motor learning from aerobic exercise to postural coordination. Thus, aerobic exercise is meaningful for conditioning motor learning to rehabilitate patients with central nervous system (CNS) disorders. However, long-term inhibition of GABAA receptors decreased the expression of cortical BDNF mRNA and decreased muscle coordination, despite the increase of BDNF in the cerebellum, suggesting that we have to consider the term of the inhibition of the GABAergic receptor for future clinical application to CNS patients.
  • Naoya Hasegawa, Kenta Takeda, Moe Sakuma, Hiroki Mani, Hiroshi Maejima, Tadayoshi Asaka
    GAIT & POSTURE 58 188 - 193 0966-6362 2017/10 [Refereed][Not invited]
     
    Augmented sensory biofeedback (BF) for postural control is widely used to improve postural stability. However, the effective sensory information in BF systems of motor learning for postural control is still unknown. The purpose of this study was to investigate the learning effects of visual versus auditory BF training in dynamic postural control. Eighteen healthy young adults were randomly divided into two groups (visual BF and auditory BF). In test sessions, participants were asked to bring the real-time center of pressure (COP) in line with a hidden target by body sway in the sagittal plane. The target moved in seven cycles of sine curves at 0.23 Hz in the vertical direction on a monitor. In training sessions, the visual and auditory BF groups were required to change the magnitude of a visual circle and a sound, respectively, according to the distance between the COP and target in order to reach the target. The perceptual magnitudes of visual and auditory BF were equalized according to Stevens' power law. At the retention test, the auditory but not visual BF group demonstrated decreased postural performance errors in both the spatial and temporal parameters under the no-feedback condition. These findings suggest that visual BF increases the dependence on visual information to control postural performance, while auditory BF may enhance the integration of the proprioceptive sensory system, which contributes to motor learning without BF. These results suggest that auditory BF training improves motor learning of dynamic postural control.
  • Kenta Takeda, Hiroki Mani, Naoya Hasegawa, Yuki Sato, Shintaro Tanaka, Hiroshi Maejima, Tadayoshi Asaka
    Journal of physiological anthropology 36 (1) 31 - 31 1880-6791 2017/07/19 [Refereed][Not invited]
     
    BACKGROUND: The benefit of visual feedback of the center of pressure (COP) on quiet standing is still debatable. This study aimed to investigate the adaptation effects of visual feedback training using both the COP and center of gravity (COG) during quiet standing. METHODS: Thirty-four healthy young adults were divided into three groups randomly (COP + COG, COP, and control groups). A force plate was used to calculate the coordinates of the COP in the anteroposterior (COPAP) and mediolateral (COPML) directions. A motion analysis system was used to calculate the coordinates of the center of mass (COM) in both directions (COMAP and COMML). The coordinates of the COG in the AP direction (COGAP) were obtained from the force plate signals. Augmented visual feedback was presented on a screen in the form of fluctuation circles in the vertical direction that moved upward as the COPAP and/or COGAP moved forward and vice versa. The COP + COG group received the real-time COPAP and COGAP feedback simultaneously, whereas the COP group received the real-time COPAP feedback only. The control group received no visual feedback. In the training session, the COP + COG group was required to maintain an even distance between the COPAP and COGAP and reduce the COGAP fluctuation, whereas the COP group was required to reduce the COPAP fluctuation while standing on a foam pad. In test sessions, participants were instructed to keep their standing posture as quiet as possible on the foam pad before (pre-session) and after (post-session) the training sessions. RESULTS: In the post-session, the velocity and root mean square of COMAP in the COP + COG group were lower than those in the control group. In addition, the absolute value of the sum of the COP - COM distances in the COP + COG group was lower than that in the COP group. Furthermore, positive correlations were found between the COMAP velocity and COP - COM parameters. CONCLUSIONS: The results suggest that the novel visual feedback training that incorporates the COPAP-COGAP interaction reduces postural sway better than the training using the COPAP alone during quiet standing. That is, even COPAP fluctuation around the COGAP would be effective in reducing the COMAP velocity.
  • Characteristic relationship betweenthe center of pressure and the center of mass during quiet standing in female ballet dancers
    Ibuki A, Mani H, Takeda K, Hasegawa N, Yamamoto K, Maejima H, Asaka T
    International Physical Medicine & Rehabilitation Journal 1 (2) 2017 [Refereed][Not invited]
  • Atsushi Okimoto, Minoru Toriyama, Masataka Deie, Hiroshi Maejima
    JOURNAL OF MOTOR BEHAVIOR 49 (6) 611 - 618 0022-2895 2017 [Refereed][Not invited]
     
    The authors aimed to characterize age-related changes in the performance of maximum reach and identify kinematic parameters that explain the age-related discrepancy between perceived and actual maximum reach distance. Maximum reach was evaluated in 22 younger women (21.3years old) and 20 older women (81.2years old). Both the perceived and actual maximum forward reach and forward excursion of the center of pressure was shorter in older women. Older women also overestimated their maximum reach distance to a greater extent. Decline of movement at the hip joint specifically correlated with both the maximum distance and the overestimation. Based on these results, decline of hip control may be a primary factor for the age-related retardation of perceived and actual maximum reach.
  • 金村 尚彦, 村田 健児, 国分 貴徳, 今北 英高, 武本 秀徳, 森山 英樹, 前島 洋, 高柳 清美
    理学療法学Supplement 公益社団法人 日本理学療法士協会 2016 420 - 420 2017 

    【はじめに，目的】

    加齢に伴い，神経機能の低下を引き起こす。走行運動における神経栄養因子に着目した先行研究では，脊髄内において神経栄養因子の活性化が報告されているが，対象が成体ラットであり，週齢の違いによる運動の影響は明らかではない。本研究では，神経生存や維持に関わる神経栄養因子と神経可塑性に関する他の因子との関連性を明らかにすることを目的とした。

    【方法】

    Wistar系雄性ラット10週齢（走行群5匹，非走行群3匹），6ヶ月週齢（走行群5匹，非走行群3匹），1年齢（走行群5匹，非走行群3匹），2年齢（走行群5匹，非走行群3匹）を対象とした。走行群は，小動物用トレッドミルにて，走行速度5.8m/min，走行時間1時間の条件で運動を課した。走行群，非走行群とランダムに分けた。実験終了後，脊髄（L3-5）を摘出し，total RNAを抽出した。逆転写反応により作成したcDNAを鋳型とし，神経栄養因子発現と他の神経形成関連因子，神経ペプチド，アポトーシス関連因子，神経突起伸長関連分子発現動態について，PCR array法（84遺伝子）により検出した。各週齢の非走行運動に対する走行群において2倍以上の発現を認めた遺伝子を抽出した。

    【結果】

    非走行群に対して2倍以上の遺伝子発現が検出された項目について結果は，10週齢では，高発現遺伝子は，検出されなかったが，低発現遺伝子は，3遺伝子（細胞分化関連遺伝子）であった。6ヶ月齢では，高発現遺伝子は，検出されなかったが低発現遺伝子は，23遺伝子（神経栄養因子一受容体，神経新生，成長因子，アポトーシス関連因子）であった。1年齢では，高発現遺伝子は6遺伝子（神経栄養因子一受容体，神経ペプチド），低発現遺伝子は，1遺伝子（アポトーシス）であった。2年齢は，高発現遺伝子は26遺伝子（神経栄養因子一受容体，神経ペプチド，神経新生），低発現遺伝子は，1遺伝子（アポトーシス）であった。

    【結論】

    長期の運動を行うことにより，神経栄養因子，神経形成成長因子等が選択的に増加し，アポトーシス因子が低発現となった。神経栄養因子が運動によって脊髄神経自体での発現が増加したことや，末梢器官で発現したその因子が脊髄内の血管や神経の逆行性輸送によって脊髄へ到達し，脊髄内のmRNA発現量が上昇し，脊髄神経が活性化されている事が示唆された。運動による機能改善は，神経単独ではなく，神経活動を活性化させる関連因子について多面的な機能連関での分析が必要となる。また週齢による遺伝子発現活性化の違いも明らかとなった。神経生存に作用する因子の影響を多面的に解析する事により，神経可塑性に対する運動の効果を明らかにできる可能性がある。

  • 萬井 太規, 長谷川 直哉, 武田 賢太, 佐藤 佑樹, 田中 晨太郎, 呉 瑕, 前島 洋, 浅賀 忠義
    理学療法学Supplement 公益社団法人 日本理学療法士協会 2016 (0) 745 - 745 2017 [Not refereed][Not invited]
     

    【はじめに，目的】

    我々は，底部が円状のバランスボード練習にて，姿勢安定性が向上することを報告した（Mani, et al., 2016）。しかしながら，関節角度の変位量のみでは，姿勢戦略の順応効果は明確にはならなかった。バランスボード上の立位では，支持基底面（Base of support：BOS）が狭く，BOSが不規則に移動することから，足関節と股関節を協調的に用いる多関節戦略が用いられることが推察される（Ooteghem, et al., 2009）。本研究の目的は，楕円解析と相互相関関数を用いて，バランスボード上立位の姿勢戦略の順応効果を示すこととした。楕円解析とは，課題中の足関節と股関節角度を二次元座標にプロットし，楕円をフィッティングさせ，その楕円の形状や傾きから両関節間の関連性を明らかにする方法である（de Lima, et al., 2014）。本研究の結果は，バランスボード練習により構築される運動パターンを示す基礎的資料となる。

    【方法】

    健常若年者17名（男性12名，22.8±1.1歳）を対象とした。被験者は矢状方向のみ不安定となる底部が円状のボード上で，できるだけ長く安定して保つように指示された。各被験者90秒以上保持できるようになるまで実施した。三次元動作解析装置および床反力計を用いて，保持時間，足圧中心点と体重心間の距離（COP―COM間距離），および下肢関節可動域（Range of motion：ROM）を算出した。楕円解析として，足関節角度を横軸，股関節角度を縦軸とした二次元座標プロットから，楕円面積，離心率，中心座標，および長軸の傾きを算出した。離心率が大きく，長軸の傾きが±1に近いほど多関節戦略，ゼロに近いほど足関節戦略が優位であると解釈される。さらに，姿勢制御変数であるCOP―COM間距離の変化量（⊿COP―COM）と各関節運動（⊿ROM）との関連性を，相互相関関数を用いて，相関係数の最大値および時間差から分析した。1回目の施行（練習前）と90秒以上保持出来た最後の施行（練習後）を対応のあるt検定を用いて比較した。危険率は5％とした。

    【結果】

    平均保持時間は練習後有意に延長した（p＜0.01）。楕円解析の結果，練習後，離心率は有意に増大し，楕円面積および長軸の傾きは有意に減少した（p＜0.05）。さらに，相互相関関数の結果，⊿COP－COMと⊿足関節ROMとの相関係数が有意に増大し，時間差が有意に減少した。一方，股関節と膝関節は，いずれも⊿COP-COMとの相関係数に有意差を認めなかった。

    【結論】

    バランスボード練習により，股関節と足関節ともに関節運動は減少する一方，股関節に比して足関節を主体とした戦略となる。また，相互相関関数の結果から，練習後，足関節を協調的に動かし重心を制御する戦略となることが示された。BOSが狭くとも底部が円状のような足関節での制御が可能な場合，中枢神経系は足関節戦略を強調することで，姿勢安定性を高めたと考えられる。姿勢戦略の構築には，BOSの大きさや足関節の自由度を考慮した課題設定が重要となることが示唆される。

  • 田中 晨太郎, 前島 洋, 浅賀 忠義, 長谷川 直哉, 武田 賢太, 大橋 哲朗, 佐藤 祐樹, 呉 暇, 丸谷 孝史, 金 雪梅, 萬井 太規
    理学療法学Supplement 公益社団法人 日本理学療法士協会 2016 (0) 1530 - 1530 2017 [Not refereed][Not invited]
     

    【はじめに，目的】

    後方へのステップ反応は，高齢者における日常生活の転倒と関連があると報告されている。非予測的な外乱方向の反復ステップ練習を行い，その効果を非予測条件で評価した研究が多く報告されている。しかし，高齢者を対象にした練習ではより安全に行える予測的な外乱方向の反復ステップ練習が望まれる。また，外乱後の姿勢反応はFeedforward制御の影響を受けることが示唆されているため，被験者自身が外乱を誘発する方法による練習効果も調べた。本研究の目的は，外乱方向が非予測的または予測的な条件，さらに被験者自身が外乱を誘発するため外乱方向およびタイミング共に予測的な条件における反復ステップ練習の効果について，非予測条件におけるステップ反応で比較検討することだった。

    【方法】

    対象は整形外科的・神経学的疾患がない健常若年者33名とし，外乱方向が予測できる反復ステップ練習をする群（以下，予測群とする。）（21.2±1.2歳），外乱方向が予測できない反復ステップ練習をする群（以下，非予測群とする。）（23.1±1.2歳），被験者自身がボタンを押して外乱を誘発する群（以下，自己誘発群とする。）（23.1±2.3歳）に11名ずつランダムに割り当てた。被験者は床面の外乱によりステップ反応が誘発された。予測群・自己誘発群は，後方へのステップ反応を誘発するために床面水平移動による前方外乱のみを60回，非予測群は前方・後方外乱を各30回（計60回）ランダムに与えられた。外乱のタイミングは予測群・非予測群はランダム，自己誘発群は被験者が意図したタイミングで行った。練習前後のテスト課題は外乱方向とタイミングはランダムに与えられた。解析対象は前方外乱に対する後方ステップのみとした。統計解析は二元配置分散分析（群間×テスト間）を用い，多重比較にTukey法を用いた。また， Pearsonの相関係数を用いた。有意水準は5%とした。

    【結果】

    練習前後のテスト間に主効果が認められ，ステップ長，ステップ速度およびステップ着地時安定性臨界が練習後有意に増加した（p＜0.01）。群間に主効果は認められなかった。ステップ着地時安定性臨界のみ交互作用が認められ，予測群および非予測群は自己誘発群と比較して練習後有意に増加した（p＜0.01）。さらに，ステップ着地時安定性臨界はステップ長，ステップ速度とそれぞれ有意な正の相関が認められた（r=0.75，r=0.75）。

    【結論】

    外乱方向およびタイミングが予測できない条件におけるステップ後の姿勢安定性は，自己誘発群よりも予測群および非予測群の方が向上し，予測群と非予測群では同程度の効果が期待できる。その要因として，ステップ長およびステップ速度の増加が挙げられる。外乱方向が予測的な反復ステップ練習は非予測的な反復ステップ練習に比して恐怖感といった心理的負担が少ないため，姿勢不安定性を有する高齢者や障害者には推奨される練習方法であると考えられる。

  • Kazurna Takahashi, Hiroshi Maejima, Gaku Ikuta, Hiroki Mani, Tadayoshi Asaka
    NEUROSCIENCE LETTERS 636 101 - 107 0304-3940 2017/01 [Refereed][Not invited]
     
    Neurotrophins play a crucial role in neuroplasticity, neurogenesis, and neuroprotection in the central nervous system. Aerobic exercise is known to increase the expression of BDNF in the cerebral cortex. Several animal studies have evaluated the tonic inhibition of GABAergic synapses to enhance hippocampal plasticity as well as learning and memory, whereas the effects of GABAergic inhibition on plasticity in the cerebral cortex related to motor learning are not well characterized. The objective of the present study was to examine the interactive effect of low-level GABA(A) receptor inhibition and exercise on the expression of neurotrophins including BDNF in the murine motor cortex. ICR mice were randomly distributed among 4 groups based on two factors of GABA(A) receptor inhibition and exercise, i.e. control group, an exercise group, a bicuculline group, and an exercise plus bicuculline group. We administered GABA(A) receptor antagonist, bicuculline intraperitoneally to the mice (bicuculline and exercise plus bicuculline group) at a non-epileptic dose of 0.25 mg/kg, whereas the mice (exercise and exercise plus bicuculline group) were exercised on a treadmill for 1 h every day. After two week intervention, the expression of mRNA and protein abundance of neurotrophins in the motor cortex was assayed using Real time PCR and ELISA. BDNF gene expression was significantly increased by approximately 3-fold in the bicuculline group relative to the control, exercise, and bicuculline plus exercise groups. Protein abundance of BDNF expression was significantly increased by approximately 3-fold in the bicuculline plus exercise group relative to other groups. Therefore, the present study revealed that combined GABA(A) receptor inhibition and moderate aerobic exercise up-regulated BDNF protein expression in the motor cortex without producing side effects on motor or cognitive functions. Alterations in BDNF expression could positively contribute to plasticity by regulating the balance between EPSPs and IPSPs in the motor cortex and thus providing a more appropriate neuronal condition for motor learning and recovery. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
  • クラシックバレエ経験者と非経験者における立位姿勢制御の比較
    伊吹 愛梨, 長谷川 直哉, 武田 賢太, 石川 啓太, 佐久間 萌, 佐藤 祐樹, 田中 晨太郎, 萬井 太規, 前島 洋, 浦賀 忠義
    理学療法学 (公社)日本理学療法士協会 43 (Suppl.2) P - 1 0289-3770 2016/10
  • hiroki mani
    理学療法科学 (一社)理学療法科学学会 31 (4) 601 - 607 1341-1667 2016/08 [Refereed][Not invited]
     
    [目的]本研究の目的は、クロスステップ反復練習の片脚立位時の姿勢安定性および姿勢戦略への即時効果を検証することである。[対象と方法]14人の健常若年者を対象とした。練習前後のテスト課題として、被験者は片脚立位姿勢を15秒保持した。練習課題は、クロスステップ動作を100回反復した。練習効果検証のため、足圧中心点(COP)から体重心(COM)までの距離(COP-COM間距離)、荷重量メカニズムとCOP位置メカニズムを算出した。[結果]練習後、片脚立位中のCOP-COM間距離は減少し、加速相で荷重量メカニズム、減速相でCOP位置メカニズムが増大した。[結語]クロスステップ練習は、姿勢戦略を変化させ、片脚立位中のCOP-COM間距離を近づける能力を高め、姿勢安定性を向上させることが示された。(著者抄録)
  • 運動と認知機能－運動による神経栄養因子の発現とシナプス修飾－
    前島 洋
    理学療法学 35 (S3) 35 - 37 2016 [Not refereed][Invited]
  • 伊吹 愛梨, 浅賀 忠義, 長谷川 直哉, 武田 賢太, 石川 啓太, 佐久間 萌, 佐藤 祐樹, 田中 晨太郎, 萬井 太規, 前島 洋
    理学療法学Supplement 公益社団法人 日本理学療法士協会 2015 (0) 585 - 585 2016 [Not refereed][Not invited]
     
    【はじめに，目的】姿勢安定性を示す指標として，足圧中心（Center of Pressure：COP）が多く用いられる。既往研究の多くは，COPの動揺が大きいほど姿勢安定性は低いと解釈されている。しかし，姿勢安定性の低下が観察されるパーキンソン病患者においては，健常者と比較してCOP動揺は小さいことが示されている（Horak, et al., 1992）。一方，バランス能力の優れているバレエダンサーの静止立位時のCOP動揺は非経験者と違いが無いという報告（Hugel, et al., 1998）もあり，COPのみを指標とすることに疑問が生じる。従って本研究の目的は，優れたバランス能力を検出するための指標について検討することだった。そのために，クラシックバレエ経験者と非経験者を対象に立位姿勢保持中のCOP，体重心（Body's center of Mass：COM），およびCOPとCOMの距離（COP-COM間距離）を比較検討した。【方法】対象者はクラシックバレエ経験のない健常若年女性10名（コントロール群，22.6±1.3歳，157.9±5.2cm，53.1±3.8kg）と，クラシックバレエ経験のある健常若年女性10名（バレエ群，23.1±1.2歳，156.7±5.4cm，44.5±2.3kg，平均経験年数15.1±4.2年）とした。課題動作は両脚立位，片脚立位，両脚つま先立ちの3条件をそれぞれ開眼・閉眼で30秒間保持することとした。赤外線カメラと三次元動作解析装置（Motion Analysis，200Hz），床反力計（Kistler，1000Hz）を用いて動作を記録し，COP座標とCOM座標を算出した。算出データはCOPおよびCOMの単位軌跡長，動揺面積，前後方向・左右方向のCOP-COM間距離とした。COP-COM間距離はCOP座標からCOM座標を引き，絶対値化してから課題時間全てを加算した値（|COP-COM|），および絶対値化せずに加算した値（COP-COM）の2変数を算出した。|COP-COM|は小さいほどCOPがCOMの近くを動いていることを示し，COP-COMは小さいほどCOPがCOMの前後（左右）を均等に動いていることを示す。統計解析は，Shapiro-wilk検定で正規性の検定を行った後，対応のないt検定とMann-WhitneyのU検定を用いて2群間の比較を行った。有意水準は5%未満とした。【結果】片脚立位動作でのみ2群間に有意差が認められた。片脚立位中の|COP-COM|およびCOP-COM双方において，前後方向・左右方向ともに両視覚条件でバレエ群がコントロール群と比較して有意に小さかった（p＜0.05）。COPおよびCOMの単位軌跡長と動揺面積は，両方向・両視覚条件で2群間に有意差は認められなかった。【結論】バレエ群の特徴として，片脚立位においてCOPがCOMのより近くを動いていることが示された。さらに，COPがCOMの前後左右をより均等に動いていることが示された。バランス能力の高い者は，COPがCOMに正確に近づき，COMの前後左右を均等に動くことで，身体に発生するモーメントを小さく且つ方向を偏らせずに制御していると考えられる。静的な姿勢安定性を示す指標として，COPとCOMの距離はCOPもしくはCOMのみに着目した指標よりも優れている。
  • 佐久間 萌, 前島 洋, 浅賀 忠義, 長谷川 直哉, 武田 賢太, 伊吹 愛梨, 石川 啓太, 田中 晨太郎, 佐藤 祐樹, 呉 瑕, 萬井 太規
    理学療法学Supplement 公益社団法人 日本理学療法士協会 2015 (0) 651 - 651 2016 [Not refereed][Not invited]
     
    【はじめに，目的】転倒は深刻な社会問題の1つであり，高齢者では安定性限界の著明な減少がみられる（Riach, et al., 1993）。従って，転倒を防ぐために狭い安定性限界での姿勢バランスの学習は重要である。姿勢バランスの学習を効率的にする手法の1つとして口頭指示がある。先行研究では，自分の体の動きに集中する「内的指示」と環境に対して運動が与える効果に集中する「外的指示」が定義されており（Wulf, et al., 2010），口頭指示の違いが姿勢バランスに影響を与えることが報告されている（Wulf, et al., 2007）。しかし，狭い安定性限界での課題において，圧中心（以下，COP），質量中心（以下，COM），圧中心と質量中心の関係性を表すCOP-COM間距離の姿勢安定性の指標やCOPの平均周波数などの姿勢戦略の指標を用いて口頭指示の影響を示した研究は我々の知る限りない。本研究は，狭い安定性限界での課題において異なる口頭指示が姿勢バランスに及ぼす影響を姿勢安定性と姿勢戦略両方の観点から検討した。【方法】健常若年者20名を内的・外的指示群の2群に無作為に分けた。左右のCOM・COPを算出するために，三次元動作解析装置と床反力計を用いた。被験者は左右に動揺する不安定板上でなるべく長く立位を保つという課題を行った。被験者は固視点を注視し，内的指示群は「自身の足のゆれ」に，外的指示群は「不安定板のゆれ」に焦点を向けるよう指示した。実験課題は，練習前後に口頭指示を与えず各3施行実施した。練習では各群に口頭指示を与え75秒間立位保持を3施行できた時点で練習終了とした。姿勢安定性の指標として，COP・COM最大偏移量，COP-COM間距離，姿勢戦略の指標としてCOPの平均周波数，姿勢安定性と姿勢戦略の関係性の指標として，COP-COM間距離とCOPの平均周波数の相関を分析した。統計解析は，練習前後の各時点での群間比較としてMann-Whitney U検定，練習前後での比較としてWilcoxon Signed-rank検定を実施した。相関検定としてSpearmanの順位相関係数を用いた。有意水準は5%とした。【結果】COP・COM最大偏移量ともに練習前後で外的指示群は有意に小さかった（p＜0.05）。しかし，COP-COM間距離は群間に有意差がなかった。COP-COM間距離とCOPの平均周波数の間に中等度の有意な正の相関が示された（r=0.5）。【結論】本研究では狭い安定性限界での課題を用いたが，先行研究と同様に外的指示で練習を行ったときに姿勢安定性がより高くなることが示された。従って，狭い安定性限界での姿勢バランス課題において，外的指示が内的指示よりも優れていることが示唆される。しかし，COP-COM間距離では口頭指示の違いが示されなかった。この結果は，口頭指示の違いよりも個人の姿勢戦略がCOP-COM間距離に影響されたことが考えられる。本研究の結果は安定性限界の狭小化が懸念されている高齢者やパーキンソン病患者へのバランス練習を提案する際の基礎的資料になると考える。
  • Hiroshi Maejima, Naohiko Kanemura, Takanori Kokubun, Kenji Murata, Kiyomi Takayanagi
    FASEB JOURNAL 29 0892-6638 2015/04 [Refereed][Not invited]
  • 予防的運動療法－その可能性と展開－
    前島 洋
    日本基礎理学療法学術誌 18 (2) 9 - 11 2015 [Not refereed][Invited]
  • Takanori Kokubun, Naohiko Kanemura, Hiroshi Maejima, Tsutomu Fujino, Sadao Morita, Kiyomi Takayanagi
    FASEB JOURNAL 27 0892-6638 2013/04 [Refereed][Not invited]
  • Hiroshi Maejima, Naohiko Kanemura, Takanori Kokubun, Kenji Murata, Kiyomi Takayanagi
    FASEB JOURNAL 27 0892-6638 2013/04 [Refereed][Not invited]
  • Kanemura Naohiko, Imagita Hidetaka, Maejima Hiroshi, Kokubun Takanori, Murata Kenji, Takayanagi Kiyomi
    FASEB JOURNAL 27 0892-6638 2013/04 [Refereed][Not invited]
  • 前島 洋, 川井伸夫, 高田治実
    帝京科学大学紀要 9 (1) 81 - 88 2013 [Refereed][Not invited]
  • 高齢者の脳の可塑性と姿勢調節機能
    前島 洋
    62 (3) 177 - 181 2012 [Not refereed][Not invited]
  • 金村 尚彦, 五十嵐 美穂, 石井 達也, 国分 貴徳, 西川 裕一, 前島 洋, 高柳 清美
    関東甲信越ブロック理学療法士学会 社団法人 日本理学療法士協会関東甲信越ブロック協議会 31 103 - 103 2012 
    【目的】
    末梢神経損傷直後より間欠的伸張運動を施行した結果、脱神経筋に対する神経再支配を促通し、神経伝導性の改善をきたす可能性が示唆されているが，神経修復や生存維持に関与している神経栄養因子脳由来神経栄養因子（brain –derived neurotrophic factor,以下BDNF）とその受容体その受容体(tyrosine kinase receptorB,以下TrkB)について，ヒラメ筋における神経栄養因子の発現について，神経損傷後のバランス運動の影響を比較検討した。
    【方法】
    坐骨神経凍結圧挫による末梢神経損傷モデルのラットを作成した。ラットは対照群、損傷後運動群、損傷後非運動群，無処置運動群の４群（各６匹）に分けた。神経圧挫術後2日目から運動群には，運動方法は、外乱刺激装置（回転角度±7度、回転速度25rpmのプラットフォーム）を用い、期間は4週間、週に5日、1日1時間実施した。実験終了後、ラットヒラメ筋を摘出し、急速凍結した．ヒラメ筋，をホモジナイザーにて粉砕後、total RNAを抽出した。total RNA からcDNA作成した。その後cDNAを鋳型とし、神経栄養因子BDNF とその受容体 TrkB mRNAプライマーを用い、リアルタイムPCR法にて解析した。．統計解析は，各beta-actin mRNA発現量で正規化したBDNF，TrkBmRNA発現量を算出し，一元配置分散分析，および多重比較検定を実施した．なお本研究は，本学実験動物倫理委員会の承認を得て実施した。
    【結果】
    BDNFmRNA発現量，TrkB mRNA発現量ともに４群において有意な差を認めなかった。
    【考察】
    ラットの運動機能を観察した結果，神経損傷後運動を行った群が足関節運動機能や，歩容の改善を認めた。末梢神経損傷後の運動介入は神経再生を促進し、早期の機能改善を得るために有効であるが推察された。坐骨神経支配下にあるヒラメ筋を対象にBDNFとその受容体TrkBに着目し，その発現量と運動の関係を探索したが，統計的な差を認めなかった。神経栄養因子の分泌は，自己分泌，傍分泌であり，神経細胞や他の器官で産出されたタンパク質を利用し，神経修復を行なっていると推察されている。本研究は，神経栄養因子を産出している筋に着目し，実験を行ったが，ヒラメ筋で産出されるBDNFやTrkBｍRNAの発現量には変化を認めなかった。ラット歩容の改善には，Schwann細胞や未分化Schwann細胞を刺激するサイトカインの分泌の影響、また運動により循環動態の改善がなどにより運動機能が改善された可能性が示唆される。今後の課題として神経修復や運動機能の改善には他の因子の探索や，損傷神経自体から発現する神経栄養因子の発現についても比較する必要がある。
  • Minoru Toriyama, Masataka Deie, Noboru Shimada, Takuya Otani, Hiroe Shidahara, Hiroshi Maejima, Hideki Moriyama, Hayatoshi Shibuya, Atsushi Okuhara, Mitsuo Ochi
    CLINICAL BIOMECHANICS 26 (5) 497 - 503 0268-0033 2011/06 [Refereed][Not invited]
     
    Background: Osteoarthritis affects the whole body, thus biomechanical effects on other joints should be considered. Unloading knee braces could be effective for knee osteoarthritis, but their effects on the contralateral knee and bilateral hip joints remain unknown. This study investigated the effects of bracing on the kinematics and kinetics of involved and contralateral joints during gait. Methods: Nineteen patients with medial compartment knee osteoarthritis were analysed. Kinematics and kinetics of the knee and hip joints in frontal and sagittal planes were measured during walking without and with bracing on the more symptomatic knee. Findings: The ipsilateral hip in the braced condition showed a lower adduction angle by an average of 2.58 degrees (range, 1.05 degrees-4.16) during 1%-49% of the stance phase, and a lower abduction moment at the second peak during the stance phase than the hip in the unbraced condition (P<0.05 and P<0.005, respectively). With bracing, the contralateral hip showed a more marked peak extension moment and lower abduction moment at the first peak (P<0.05), and the contralateral knee adduction angle increased by an average of 0.32 degrees (range, 0.21 degrees-0.45 degrees) during 46%-55% of the stance phase (P<0.05), compared to no bracing. Interpretation: Unloading bracing modified the contralateral knee adduction angle pattern at a specific time point during gait. It also affected the frontal plane on the ipsilateral hip and the frontal and sagittal planes on the contralateral hip joint. Consideration should be provided to other joints when treating knee osteoarthritis. (C) 2011 Elsevier Ltd. All rights reserved.
  • Takuya Otani, Hiroshi Maejima, Yoshiko Tobimatsu, Noboru Shimada, Minoru Toriyama, Masataka Deie
    JOURNAL OF PHYSICAL THERAPY SCIENCE 22 (1) 69 - 74 0915-5287 2010/02 [Refereed][Not invited]
     
    [Purpose] It is not clear whether changes in the neural networks within the primary motor area contralateral to the infarct hemisphere influence the recovery of neurological functions after strokes. Thus, we investigated whether the number of synapses increased within the contralateral primary motor area after brain infarction. [Subjects] Twenty-four Wistar rats (8 weeks old) were randomly allocated to ischemic or control groups. [Methods] Rats underwent middle cerebral artery occlusion surgery (ischemic group) or sham surgery (control group). All rats underwent two kinds of neurological examination on day 1 after surgery and again 2 and 4 weeks after Surgery. The expression of synaptophysin and PSD-95 within the contralateral primary motor area was investigated by western blot analysis. [Results] In the ischemic group, the neurological scores at 4 weeks after Surgery were significantly better than those on day 1. There were no significant differences between the two groups in the expression of synaptophysin and PSD-95. [Conclusion] Neurological functions significantly improved after brain infarction, but the number of synapses did not change within the contralateral primary motor area. These findings suggest that changes in synapse number within the contralateral primary motor area are not related to functional improvement after brain infarction.
  • Hiroshi Maejima, Hitoshi Sunahori, Yuji Kanetada, Azusa Murase, Yoshiko Tobimatsu, Takuya Otani, Osamu Yoshimura
    CLINICAL BIOMECHANICS 24 (6) 499 - 503 0268-0033 2009/07 [Refereed][Not invited]
     
    Background: Reflecting the rapidly aging population, community-based interventions in the form of physical exercise have been introduced to promote the health of elderly persons and prevent falls. Postural response is the critical neural response for preventing falls. The objective of this study was to assess the effect of long-term daily exercise on neural adjustment in postural response elucidated by sudden postural perturbation. Methods: Twenty-six community-based elderly persons (13 men and women; 69.8 +/- 0.5 years old) participated in this study. Daily exercise was composed of walking for longer than 30 min, stretching, muscle strengthening and balance exercise, and was continued for 3 months. Postural responses were induced by fore or aft horizontal displacement of a platform with a force plate. Center of pressure on the force plate and electromyography of the rectus femoris, tibia anterior, biceps femoris and gastrocnemius were measured in postural response. Findings: Following the 3 months of physical intervention, the amplitude and timing of the center of pressure excursion did not change, whereas the amplitude of muscular activities of the lower leg muscles required for the response significantly decreased. Furthermore, the onset of muscular activation of the lower leg muscles was significantly shortened following the intervention. Interpretation: In conclusion, we showed that a program composed of 3 months of comprehensive exercise modulated the output of the postural response through a neural adjustment in the timing and amplitude of the muscular activation. (c) 2009 Elsevier Ltd. All rights reserved.
  • Hiroshi Maejima, Hitoshi Sunahori, Takuya Otani, Nozomi Sakamoto, Osamu Yoshimura, Yoshiko Tobimatsu
    NURSING & HEALTH SCIENCES 11 (2) 128 - 134 1441-0745 2009/06 [Refereed][Not invited]
     
    It is widely accepted that daily exercise improves the dynamic standing balance of elderly persons. In the current study, 77 community-dwelling Japanese elderly persons (aged 71.1 +/- 0.5 years) participated in a daily exercise program to assess its effect on their dynamic standing balance. The daily exercise consisted of walking, stretching, muscle strengthening, and balance exercises. The program ran for 31 months and the dynamic standing balance was assessed at the start of the program and again at 3, 7, 12, 19, 24, and 31 months. In most of the tests of dynamic standing balance, the measured values improved drastically in the first 7 months; thereafter, they either reached a plateau or continued to improve more slowly. These findings can contribute to the future planning of community-based exercise programs; in particular, the length of the program and the timing of changes to the exercise load.
  • Hikmat Hadoush, Yoshiko Tobimatsu, Akiyoshi Nagatomi, Hiroaki Kimura, Yoshihiro Ito, Hiroshi Maejima
    JOURNAL OF PHYSIOLOGICAL SCIENCES 59 (3) 243 - 247 1880-6546 2009/05 [Refereed][Not invited]
     
    Bipolar and monopolar surface electromyography (sEMG) are known procedures to measure the H-reflex. However, signal cancellation is a potential experimental problem of bipolar sEMG. The results of our study show that monopolar sEMG was the more sensitive procedure to differentiate motoneuron excitability at different passive muscle stretching speeds as it overcame signal cancellation.
  • 地域に根ざした運動介入が高齢者のバランス機能に与える長期的効果
    前島 洋
    広島転倒予防研究会誌 9 (1) 15 - 17 2009 [Refereed][Not invited]
  • The mRNA expression of neurotrophins in different skeletal muscles of young rats
    Saka Y, Yoshimura O, Tahara H, Takeda Y, Moriyama H, Maejima H, Tobimatsu Y
    Hiroshima Journal of Medical Sciences 56 (3) 12 - 18 2008 [Refereed][Not invited]
  • Hiroshi Maejima, Yuji Kanetada, Hitoshi Sunahori, Azusa Murase, Takuya Otani, Nozomi Sakamoto, Osamu Yoshimura, Yoshiko Tobimatsu
    Journal of the Japanese Physical Therapy Association 11 (1) 7 - 13 1344-1272 2008 [Refereed][Not invited]
     
    The objective of this study was to assess the effect of comprehensive exercise program widely accepted as a community-based physical intervention for the prevention of failing in the elderly persons on their controlling standing balance. Twenty-six comminity-dwelling elderly persons (13 males and females 69.8 ± 2.8 years old) participated in this study. Daily exercise was comprised of walking for more thin 30 min, stretching, muscle strengthening and balance exercise without exercise equipments. The intervention was continued for three months. Indicators of standing balance related to static balance, dynamic balance and postural response were measured before and after the intervention. As an effect of the intervention on static balance, the sway of center of pressure (COP) in the static stance significantly increased. In the dynamic balance, significant improvements were observed in one leg standing time, the 10-m gait time, functional reach. Additionally, the maximal movable length of COP which subjects can move voluntarily to right and left significantly increased. In the postural response, the integrated electromyography (IEMG) induced by postural response for sudden postural perturbation significantly decreased in the lower leg muscles. Since less muscular activities were sufficient to maintain posture, it was suggested that postural response was elicited more efficiently following the intervention. This study suggested that the comprehensive exercise program, which his been widely introduced as community-based interventions for the prevention of falling, have extensive effects on the control of standing balance covering static balance, dynamic balance and postural response in the elderly persons.
  • Hiroshi Maejima, Azusa Murase, Hitoshi Sunahori, Yuji Kanetada, Takuya Otani, Osamu Yoshimura, Yoshiko Tobimatsu
    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 211 (2) 141 - 149 0040-8727 2007/02 [Refereed][Not invited]
     
    Reflecting the rapidly aging population, community-based interventions in the form of physical exercise have been introduced to promote the health of elderly persons. Many investigation studies have focused on muscle strength in the lower leg as a potent indicator of the effect of physical exercises. The objective of this study was to assess the effect of long-term daily exercises on neural command in lower leg muscle activations. Twenty-six community-based elderly persons (13 men and 13 women; 69.8 +/- 0.5 years old) participated in this study. Daily exercise was comprised of walking for more than 30 min, stretching, muscle strengthening and balance exercise, and was continued for three months. Muscle strength and surface electromyography of the tibia anterior, rectus femoris, and biceps femoris were measured in maximum isometric voluntary contraction both before and after the intervention. The mean frequency of the firing of motor units was calculated based on fast Fourier transformation of the electromyography. As the results of the intervention, muscle strength increased significantly only in biceps femoris, whereas the mean frequency of motor units decreased significantly in every muscle, indicating that motor unit firing in lower frequency efficiently induces the same or greater strength compared with before the intervention. Thus, synchronization of motor units compensates for the lower frequency of motor unit firing to maintain muscular strength. In conclusion, long-term physical exercises in the elderly can modulate the neural adjustment of lower leg muscles to promote efficient output of muscle strength.
  • Shigeki Moriguchi, Norifumi Shioda, Hiroshi Maejima, Xilong Zhao, William Marszalec, Jay Z. Yeh, Kohji Fukunaga, Toshio Narahashi
    MOLECULAR PHARMACOLOGY 71 (2) 580 - 587 0026-895X 2007/02 [Refereed][Not invited]
     
    Nicotinic acetylcholine receptors and N- methyl- D- aspartate ( NMDA) receptors are known to be down- regulated in the brain of Alzheimer's disease patients. We have previously demonstrated that the nootropic drug nefiracetam potentiates the activity of both nicotinic acetylcholine and NMDA receptors and that nefiracetam modulates the glycine binding site of the NMDA receptor. Because the NMDA receptor is also modulated by Mg2+ and protein kinases, we studied their roles in nefiracetam action on the NMDA receptor by the whole- cell patch- clamp technique and immunoblotting analysis using rat cortical or hippocampal neurons in primary culture. The nefiracetam potentiation of NMDA currents was inhibited by the protein kinase C ( PKC) inhibitor chelerythrine, but not by the protein kinase A ( PKA) inhibitor N-[ 2-( 4- bromocinnamylamino) ethyl]- 5- isoquinoline ( H89). In immunoblotting analysis, nefiracetam treatment increased the PKC alpha activity with a bell- shaped dose-response relationship peaking at 10 nM, thereby increasing phosphorylation of PKC substrate and NMDA receptor. Such an increase in PKC alpha-mediated phosphorylation was prevented by chelerythine. Nefiracetam treatment did not affect the PKA activity. Analysis of the current-voltage relationships revealed that nefiracetam at 10 nM largely eliminated voltage- dependent Mg2+ block and that this action of nefiracetam was sensitive to PKC inhibition. It was concluded that nefiracetam potentiated NMDA currents not by acting as a partial agonist but by interacting with PKC, allosterically enhancing glycine binding, and attenuating voltage- dependent Mg2+ block.
  • OTANI Takuya, MARUISHI Masaharu, SAKAMOTO Nozomi, KANASHIMA Naoko, SUNAHORI Hitoshi, MAEJIMA Hiroshi, YOSHIMURA Osamu, TOBIMATSU Yoshiko
    理学療法学 公益社団法人日本理学療法士協会 34 (3) 79 - 87 0289-3770 2007 [Refereed][Not invited]
     
    The aim of this study was to investigate the effect of a cognitive task on postural stability of patients with mild traumatic brain injury (TBI). The patients with mild TBI and healthy subjects (control) were asked to stand quietly on a force platform while performing the backward digit recall task. To determine whether the backward digit recall task requires attention or not, we also investigated the effect of the backward digit recall task on the reaction time of task performance. The backward digit recall task influenced the reaction time significantly, but, the effect of this task on the center of pressure parameters did not differ significantly between the patients with mild TBI and healthy subjects. This result suggests that the effect of the cognitive task on postural stability may not markedly differ between the patients with mild TBI and healthy subjects.
  • 認知症高齢者の外乱時に対する姿勢制御について
    坂本 望, 大谷拓哉, 新小田幸一, 前島 洋, 吉村 理, 飛松好子
    理学療法学 34 (2) 45 - 51 2007 [Refereed][Not invited]
  • 河野一郎, 高杉紳一郎, 岩本幸英, 飛松好子, 前島 洋, 森山英樹, 武本秀徳, 坂 ゆかり, 大谷拓哉
    国立大学法人リハビリテーションコ・メディカル学術大会誌 国立大学理学療法士協議会 28 (1) 55 - 57 1882-1995 2007 [Refereed][Not invited]
  • 片脚大腿切断者における足圧中心点を指標とした静止立位時の姿勢制御−ソケット形状による影響−
    河野一郎, 飛松好子, 前島 洋, 森山英樹, 武本秀徳, 坂ゆかり, 大谷拓也, 高杉紳一郎, 岩本幸英
    広島大学保健学ジャーナル 6 (1) 17 - 23 2006 [Refereed][Not invited]
  • 宮本英高, 金村尚彦, 佐々木久登, 田中幸子, 白濱勲二, 森山英樹, 坂ゆかり, 堤恵理子, 前島洋, 吉村理
    総合リハビリテーション 医学書院 33 (1) 65 - 71 0386-9822 2005 [Refereed][Not invited]
  • MAEJIMA Hiroshi, SUNAHORI Hitoshi, YOSHIMURA Osamu, TOBIMATSU Yoshiko
    Bulletin of the Japanese Society of Prosthetic and Orthotic Education, Research and Development Japanese Society of Prosthetics and Orthotics 21 (1) 25 - 30 0910-4720 2005 [Not refereed][Not invited]
  • H Moriyama, O Yoshimura, H Sunahori, H Nitta, H Imakita, Y Saka, H Maejima, Y Tobimatsu
    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 204 (1) 37 - 44 0040-8727 2004/09 [Refereed][Not invited]
     
    Joint contractures following central nervous system injuries remain a prevalent and significant complication, but no reports are available on evidence of contracture formation over time. The objective of this study was to determine the rate of contracture progression and the direction of loss in joint movement following spinal cord injuries (SCI). Forty-eight female Wistar rats were used. Twenty-four experimental rats underwent a spinal cord transection at the level of T8 and 24 control rats underwent a sham-operation. The animals were studied at each of 5 time points: 2, 4, 8, 12, 16, and 24 weeks after surgical intervention. The degree of contractures was assessed by measuring the femorotibial angle on both hindlimbs with the use of a goniometer. Knee joint motion was measured for flexion and extension direction. Knee flexion contractures developed in all experimental rats. The restriction in motion progressed during the first 12 weeks and plateaued thereafter. The contractures were produced almost exclusively by a loss in the extension range of motion. This study defined the time course that contracture progression was more rapid in the early stage after SCI and stabilized in the later stage of injury. Contractures following SCI occurred in flexion at the knees and resulted from a loss of extension. These findings should help guide timely treatment and provide a better understanding of contracture development. (C) 2004 Tohoku University Medical Press.
  • 今北 英高, 峯松 亮, 小林 隆司, 金村 尚彦, 佐々木 久登, 田中 幸子, 前島 洋, 吉村 理, 白濱 勲二
    日本職業・災害医学会会誌 52 (3) 170 - 176 1345-2592 2004/05 [Refereed][Not invited]
     
    不活動モデルとしてWistar系ラットに坐骨神経切除術を施し,骨格筋の退行性変化を観察した.さらに除神経に伴う萎縮筋に対し,刺入電極による直接的電気刺激を加え,骨格筋の強制収縮を行った.その結果,電気刺激による収縮により筋湿重量の低下,筋線維の萎縮速度を抑制出来ることが示唆された.また,電気刺激における周波数の違いによっても,効果の違いが現れる可能性が考えられた
  • 坂本 望, 森山 英樹, 今北 英高, 前島 洋, 吉村 理, 白濱 勲二
    日本職業・災害医学会会誌 (一社)日本職業・災害医学会 52 (3) 161 - 165 1345-2592 2004/05 [Refereed][Not invited]
     
    痴呆は高齢者転倒の危険因子の一つで,痴呆を有さない高齢者より,痴呆を有する高齢者に転倒回数が多いという報告もあるが,その一方で痴呆を有する高齢者への研究や介入は少ない.そこで,痴呆専門棟(痴呆棟)での転倒状況を転倒報告書より調査し,どの要因が大きく転倒に寄与していたか検討した.第1因子には「N-ADL,NMスケール,HDS-R」に因子負荷量が多く,「本人の能力」と命名した.第2因子には「要介護度,日常生活自立度」に因子負荷量が多く,「自立度」と命名した.第3因子には「HDS-R,NMスケール」に因子負荷量が多く,「精神機能」と命名した.痴呆棟における転倒は,身体,精神機能面に大きく関係していることが示唆された.痴呆棟の転倒要因に外的要因に関する項目は抽出されず,身体的要因に関する項目が,転倒に大きく関係していた.内的要因でも,特に精神機能面に関する項目が多く抽出された
  • 高齢者におけるバランス機能評価と運動介入の効果
    前島 洋, 砂堀仁志, 坂本 望, 吉村 理
    広島理学療法学 13 (1) 22 - 25 2004 [Refereed][Not invited]
  • Hiroshi Maejima, Kiyohisa Takeishi, Hitoshi Sunahori, Akiko Yamawaki, Kiyomi Nakajima, Osamu Yoshimura
    Journal of the Japanese Physical Therapy Association 7 (1) 7 - 14 1344-1272 2004 [Refereed][Not invited]
     
    Falling due to unstable standing balance is considered to be the main cause of bone fractures, which lead elderly persons to becoming bedridden. Thus, the standing balance of elderly persons is being given increasingly greater attention. On the other hand, postural deformation caused by deformation in the spine and lower leg joints is considered to have an effect on standing balance. The objective of this study is to clarify the effect of postural deformation on the following three categories of standing balance 1) the ability to immobilize Center of Gravity (COG) in standing statically, 2) the ability to control COG during movement and 3) the postural response induced by postural sway. Fifty elderly persons (age:77.7 ± 6.4 years old, fifty females) participated in this study. Postural deformation was measured using a Spinal Mouse, a device for non-invasive measurement of spinal curvature and photographic image in sagittal plane. In line with to Nakata's classification of postural deformation, subjects were classified by extension type, S-character deformation type, flexion type, hands on the knee type and normal group. In order to assess the ability to immobilize COG in static standing, Center of Pressure (COP) in static standing was measured for 30 sec. In order to assess the ability to control COG during movement, functional reach, maximal length of stride and the period of 10 m gait were measured. Postural response was induced by fore-aft perturbation of the platform on which the subjects stood. Postural responses were assessed by measuring both COP, and electromyography (EMG) of muscles in the lower legs. There was little significant difference among the five groups concerning postural deformation in every measured item, neither in the ability to immobilize COP in static standing, nor in the postural response induced by postural sway. However, the results of measured items concerning the ability to control COG during movement were significantly worse in flexion type and hands on the knee type compared with the normal group. It was suggested that postural deformation in elderly persons effects exclusively on the ability to control COG during movement in standing balance.
  • Akira Minematsu, Osamu Yoshimura, Hiroshi Maejima, Takahide Miyamoto
    Hiroshima Journal of Medical Sciences 52 (2) 21 - 25 0018-2052 2003/06 [Refereed][Not invited]
     
    This study investigated the time-course of changes in bone mechanical strength in rats with spinal cord injury (SCI). Sixty-four male Wistar rats underwent spinal cord transection at the thoracic nerve. Control rats underwent a sham procedure (SHAM). Animals were sacrificed at day 1, 4, 7 and 14 after operation. The mechanical strength of the left femur and tibia was measured by the three-point bending strength test. The bones were dried, weighed and burned to ash. A specimen of right tibia was prepared and examined under a microscope. Bone mechanical strength, dry bone weight, and ash content of the femur and tibia in SCI rats were significantly lower than those in SHAM animals. Dry bone weight and ash content began to decrease from the 4th day after SCI and reached their lowest at day 7 after operation. Bone mechanical strength had reduced significantly by the 14th day. Gaps and spaces were observed in the trabecular area at the same time. After SCI, calcified cartilage decreased and the reduction of bone mass occurred rapidly. Moreover, a decline of bone mechanical strength is caused within 2 weeks. Thus, SCI led to the atrophy of bone and caused the reduction of mechanical strength at an early stage. It is thus necessary to prevent bone loss after SCI immediately.
  • Hiroshi Maejima, Eiji Kinoshita, Issei Seyama, Kaoru Yamaoka
    Journal of Biological Chemistry 278 (11) 9464 - 9471 0021-9258 2003/03 [Refereed][Not invited]
  • 高齢者の脳の可塑性と姿勢調節機能
    前島 洋
    体育の科学 62 (3) 177 - 181 2003 [Not refereed][Not invited]
  • 転倒予防教室
    前島 洋
    広島県臨床整形外科医会会誌 6 (1) 31 - 33 2003 [Not refereed][Not invited]
  • 生物毒Grayanotoxinを用いた電位依存性Na+チャンネルの構造−機能相関に関する研究
    前島 洋
    学位論文（広島大学） 1 - 83 2003 [Refereed][Not invited]
  • MATSUNARI Yuko, FUJII Tomie, MIYAKOSHI Yukiko, MAEJIMA Hiroshi, YOSHIMURA Osamu, ITO Tomoko
    Japanese Journal of Health and Human Ecology The Japanese Society of Health and Human Ecology 69 (5) 169 - 179 0368-9395 2003 [Refereed][Not invited]
     
    In recent years, the objection has recited to carry out physical restraints. Development of tools became pressing need. Side-supports utilize safety catches for users on the beds. The present research was conducted to examine any potential physical influence resulting from differences in adjunctive bed implements. Four healthy women of 21-23 years of age were involved in this study. The subjects were studied for 2 days. Each subject slept on two kinds of beds, and the subject's sleep level was measured using a vigilance level measurement (Bispectral Index = BIS). In this there was a Time Series transformations: difference (1). We compared the sleep data of all 4 subjects for the side rail bed conditions and side support bed conditions. In 3 subjects, there was a difference of the sleep data related to the type of adjunctive implement. We compared data when the bodies of the subjects moved in the period of the sleep. In all 4 subjects, there was difference of the movement data according to the type of adjunctive implement. We concluded that these were due to physiological reactions in the body. The quality of sleep was affected by of the bed conditions.
  • 地域高齢者を対象とした運動介入の効果
    砂堀仁志, 金只悠司, 前島 洋, 高石あずさ, 吉村 理
    広島転倒予防研究会誌 3 (1) 2 - 4 2003 [Refereed][Not invited]
  • H Maejima, E Kinoshita, T Yuki, M Yakehiro, Seyama, I, K Yamaoka
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 295 (2) 452 - 457 0006-291X 2002/07 [Refereed][Not invited]
     
    We located a novel binding site for grayanotoxin on the cytoplasmic linkers of voltage-dependent cardiac (rH1) or skeletal-muscle (mu1) Na+ channel isoforms (segments S4-S5 in domains D1 and D4), using the alanine scanning substitution method. GTX-modification of Na+ channels, transiently expressed in HEK 293 cells, was evaluated under whole-cell voltage clamp, from the ratio of maximum chord conductance for modified and unmodified Na+ channels. In mu1, Mutations K237A, L243A. S246A. K248A, K249A, L250A, S251A, or T1463A, caused a moderate, but statistically significant decrease in this ratio. On making corresponding mutations in rH1, only L244A dramatically reduced the ratio. Because in mu1. the serine at position 251 is the only heterologous residue with respect to rH1 (Ala-252), we made a double Mutant L243A&S251A to match the sequence of mu1 and rH1 in S4-S5 linkers of both domains. This double mutation resulted in a significant decrease in the ratio, to the same extent its L244A substitution in rH1 did, indicating that the site at Leu-244 in rH1 or at Leu-243 in mu1 is a novel one, exhibiting a synergistic effect of grayanotoxin. (C) 2002 Elsevier Science (USA). All rights reserved.
  • H Kawagoe, K Yamaoka, E Kinoshita, Y Fujimoto, H Maejima, T Yuki, Seyama, I
    FEBS LETTERS 513 (2-3) 235 - 241 0014-5793 2002/02 [Refereed][Not invited]
     
    Cardiac sodium channels have been shown to have a higher sensitivity to local anesthetic agents, such as lidocaine, than the sodium channels of other tissues. To examine if this is also true for mexiletine, we have systematically measured mexiletine sensitivity of the Na channel isoforms, rH1, mu1, and rBII, which were transiently expressed in human embryonic kidney (HEK) 293 cells. We confirmed that the cardiac isoform rH1 exhibited the highest sensitivity among the three tested channel isoforms. In rH1, mu1, and rBII, the respective IC50 values were 62, 294, and 308 muM mexiletine, in regard to tonic block, and 18, 54, and 268 muM mexiletine, in relation to use (8 Hz)-dependent block. The relatively high drug sensitivity of rH1 was an invariant finding, irrespective of channel state or whether channels were subjected to infrequent or frequent depolarizing stimuli. Mutating specific amino acids in the skeletal muscle isoform mu1 (namely, mu1-I433V and mu1-S251A) to those of the cardiac isoform at putative binding sites for local anesthetic agents revealed that only one of the point mutations (mu1-S251A) has relevance to the high cardiac drug sensitivity, because mexiletine produced significantly more use-dependent and tonic block in mu1-S251A than wild-type mu1. (C) 2002 Published by Elsevier Science BY, on behalf of the Federation of European Biochemical Societies.
  • MAEJIMA Hiroshi, SASAKI Hisato, MORIYAMA Hideki, KANEMURA Naohiko, SHIRAHAMA Kunji, MIYAMOTO Hidetaka, YOSHIMURA Osamu
    日本義肢装具学会誌 18 (1) 25 - 27 0910-4720 2002 [Not refereed][Not invited]
  • 長期化した小児脊髄損傷例
    吉村 理, 長谷川好記, 前島 洋, 木村浩彰
    日本パラプレジア医学会誌 15 (1) 120 - 121 2002 [Refereed][Not invited]
  • 糖尿病足
    吉村 理, 前島 洋, 佐々木久登, 金村尚彦, 白濱勲二, 宮本英高, 森山英樹
    日本義肢装具学会誌 18 (1) 28 - 31 2002 [Not refereed][Not invited]
  • SASAKI Hisato, KANEMURA Naohiko, TANAKA Sachiko, SHIRAHAMA Kunji, MIYAMOTO Hidetaka, MAEJIMA Hiroshi, YOSHIMURA Osamu
    日本義肢装具学会誌 18 (1) 22 - 24 0910-4720 2002 [Not refereed][Not invited]
  • ベッド環境が寝返り動作およびその介助動作に与える影響
    前島 洋, 宮腰由紀子, 松成裕子, 藤井宝恵, 森山英樹, 田中幸子, 吉村 理
    日職災医誌 50 (3) 219 - 226 2002 [Refereed][Not invited]
  • 除神経筋に対する電気刺激の影響
    宮本英高, 峯松 亮, 小林隆司, 佐々木久登, 金村尚彦, 田中幸子, 白濱勲二, 堤恵理子, 前島 洋, 吉村 理
    広島理学療法学 11 (1) 82 - 86 2002 [Refereed][Not invited]
  • MATSUNARI Yuko, FUJII Tomie, MIYAKOSHI Yukiko, MAEJIMA Hiroshi, YOSHIMURA Osamu, ITO Tomoko
    Japanese Journal of Health and Human Ecology The Japanese Society of Health and Human Ecology 68 (6) 216 - 227 0368-9395 2002 [Refereed][Not invited]
     
    In recent years, the objection has recited to carry out physical restraints. Development of new tools became pressing need. Side-supports utilize safety catches for users on the beds. The present research was conducted to examine any potential physical influence resulting from differences in adjunctive bed implements. Four women of 21-23 years old, healthy were involved. Subjects were studied for 2 days. A subject sleeps on two kinds of beds so that it may be usual. A subject's sleep level is measured using a vigilance level measurement (Bispectral Index=BIS). A BIS value is the time series. Differences in the sleep data between side rail bed conditions and side support bed conditions were evaluated with Student's t test. In all 4 subjects, the sleep data were significantly different (P<0.0o1). Correlation was shown in the sleep data in side support bed conditions among subjects. Correlation was shown in the sleep data in side rail bed conditions among subjects. The highest correlation was in side support bed. The Pearson's correlation coefficient between a case 1 and a case 2 was 0.597. This concludes that the reaction was in physiology and the body. Influence is brought to the quality of sleep of subjects according to bed conditions.
  • MATSUNARI Yuko, FUJII Tomie, MIYAKOSHI Yukiko, MAEJIMA Hiroshi, YOSHIMURA Osamu, YONEHARA Naoko, ITO Tomoko
    Japanese Journal of Health and Human Ecology The Japanese Society of Health and Human Ecology 68 (5) 167 - 175 0368-9395 2002 [Refereed][Not invited]
     
    In 1999, the Ministry of Health, Labor and welfare produced "A Guide to Zero Body Restraint (shintai kousoku zero he no tebiki)". The Guide indicates that beds should not be surrounded by bed-fences (side-rails) that might prevent patients from getting out of bed unassisted. However, until then, side-rails had been used to maintain the comfort and safety of patients. Side-supports utilize safety catches for users on the beds. The present research was conducted to examine any potential psychological influence resulting from differences in adjunctive bed implements. Methods: A total of 31 undergraduate students from University "A" participated after providing informed consent. Two beds were prepared and side-supports were installed in one bed, and side-rails in the other. Subjects lay on a bed for 50 minutes. The Semantic Differential method was used to estimate feelings associated with use of the bed, and involved subjects completing a 15-item questionnaire. The method was then repeated for the other bed. Differences in responses between the groups were compared using the Wilcoxon matched pairs signed ranks test. Results: In the evaluation using the Semantic Differential method, difference in psychological response to side-supports and side-rails was found. Significant differences were observed for 11 of the 15 questionnaire items. The environment with the bed attached side-support displayed a more positive image than that of the side-rails bed Conclusion: A clear difference in the influence of environments was identified. Problems with bed conditions should be addressed immediately.
  • 高齢者における身体アライメント変形が立位バランスに与える影響
    森山英樹, 前島 洋, 武石清久, 砂堀仁志, 中島清美, 吉村 理
    広島転倒予防研究会誌 2 (1) 4 - 7 2002 [Refereed][Not invited]
  • Naohiko Kanemura, Ryuji Kobayashi, Hiroki Kajihara, Akira Minematu, Hisato Sasaki, Sachiko Tanaka, Kunji Shirahama, Hidetaka Miyamoto, Makoto Watanabe, Kaori Yata, Hideki Moriyama, Hiroshi Maejima, Osamu Yoshimura
    Journal of Physical Therapy Science 14 (1) 27 - 32 0915-5287 2002 [Refereed][Not invited]
     
    In this study, the effect of weightlessness on mechanoreceptors in ACL was investigated in rats with hindlimb suspension. The animals used in the present study were 20 Wistar male rats (weight: 278 ± 16 g). The animals were divided into 2 groups: the Suspension group (n=10, suspended for 4 weeks) and Control group (n=10, non-suspended for 4 weeks). ACL was stained with gold chloride. The frozen section was sliced to be approximately 45 μm in thickness using a cryostat. The tissue preparations were observed through an optical microscope. Based on the criteria proposed by Freeman and Wyke, mechanoreceptor was specified and counted. Four types of nerve endings, Pacinian corpuscle, Ruffini corpuscle, Golgi tendon organ-like receptor, and free nerve ending were observed. In the Susupension group, atypical Pacinian corpuscle, and Ruffini corpuscle were observed. The number of mechanoreceptors were significantly decreased in the Suspension group (median 10) compared with the Control group (median 17) (Mann Whitney U test Z=-2.65, P< 0.01). It might be necessary to perform also to early rehabilitation to prevent the degeneration of mechanoreceptors and take into consideration the nerve control system in the clinical setting.
  • 筋放電休止期と反応時間およびバランス能力との関係
    佐々木久登, 荒井隆志, 金村尚彦, 田中幸子, 白濱勲二, 宮本英高, 森山英樹, 吉村 理, 前島 洋
    日本職業・災害医学会会誌 50 (2) 145 - 151 2002 [Refereed][Not invited]
  • 高齢大腿骨頸部骨折患者の中殿筋筋電図周波数特性に関する検討
    前島 洋, 佐々木久登, 田中幸子, 金村尚彦, 森山英樹, 白濱勲二, 宮本英高, 吉村 理
    日本職業・災害医学会会誌 50 (2) 107 - 111 2002 [Refereed][Not invited]
  • 歩行障害のメカニズムと鑑別診断 痙性対麻痺歩行障害
    吉村 理, 前島 洋, 金村尚彦, 森山英樹, 坂田 清
    日本義肢装具学会誌 18 (1) 997 - 1002 2002 [Not refereed][Not invited]
  • SHIRAHAMA Kunji, KOBAYASHI Ryuji, SASAKI Hisato, TANAKA Sachiko, KANEMURA Naohiko, MIYAMOTO Hidetaka, MORIYAMA Hideki, MINEMATSU Akira, MAEJIMA Hiroshi, YOSHIMURA Osamu
    日本義肢装具学会誌 18 (1) 62 - 66 0910-4720 2002 [Not refereed][Not invited]
  • T Kimura, K Yamaoka, E Kinoshita, H Maejima, T Yuki, M Yakehiro, Seyama, I
    MOLECULAR PHARMACOLOGY 60 (4) 865 - 872 0026-895X 2001/10 [Refereed][Not invited]
     
    We searched for sites on the alpha -subunit of the fast Na+ channel responsible for the difference in GTX (grayanotoxin) sensitivity of the skeletal- and cardiac-muscle Na+ current. cDNA clones, encoding the skeletal or cardiac isoforms of the alpha -subunit, were inserted into a mammalian expression vector and transiently transfected into human embryonic kidney cells. The expressed channels were measured using whole-cell patch-clamp techniques and examined for GTX sensitivity. As a measure of GTX sensitivity, we used relative chord conductance (ratio of maximum chord conductance of noninactivating GTX-modified Na+ currents to that of unmodified peak currents). Wild-type channels from skeletal muscle (mu1) were more sensitive to GTX modification than wild-type cardiac channels (rH1) by a factor of 1.6. To facilitate exploration of a-subunit sites determining GTX sensitivity, we used SHHH, a chimera of skeletal muscle (S) domain D1 and heart muscle (H) domains D2D3D4 with supernormal sensitivity to GTX I (1.5-fold of wild-type mu1). Successive replacement of Ser-251 (D1S4-S5 intracellular loop) and IIe-433 (D1S6 transmembrane segment), with corresponding rH1 residues Ala and Val, reduced, in a stepwise manner, the GTX sensitivity of the chimera and related mutants to that of wild-type rH1 We concluded that, in addition to IIe-433, known as the GTX-binding site, Ser-251 represents a novel site for GTX modification.
  • Eiji Kinoshita, Hiroshi Maejima, Kaoru Yamaoka, Katsuhiro Konno, Nobufumi Kawai, Eisuke Shimizu, Sawana Yokote, Hitoshi Nakayama, Issei Seyama
    Molecular Pharmacology 59 (6) 1457 - 1463 0026-895X 2001/06/01 [Refereed]
  • 再考「利用者の幸福感に関連する要因」
    小林 隆司, 峯松 亮, 細田 昌孝, 佐々木 久登, 前島 洋, 松田 祐一, 田中 幸子, 松尾 彰久, 金村 尚彦, 吉村 理, 高柳 清美
    作業行動研究 日本作業行動学会 5 (1) 58 - 59 0919-5300 2001/03 [Not refereed][Not invited]
  • 吉村 理, 前島 洋, 小林隆司, 峯松 亮, 佐々木久登, 田中幸子, 金村尚彦, 白濱勲二, 上田健人, 上田千絵, 渡辺 誠, 矢田かおり, 宮本英高, 森山英樹, 加藤 浩, 河元岩男
    Journal of health sciences, Hiroshima University 広島大学大学院保健学研究科 1 (1) 73 - 77 1347-7323 2001 [Refereed][Not invited]
     
    頚髄損傷の評価では,頚髄の損傷の程度と損傷高位が重要である.米国脊髄損傷協会は,脊髄損傷の障害の評価法を発表し,脊髄損傷の神経学的および機能的分類のための国際基準として現在国際的に使用されている.しかし可能性に挑戦するリハビリテーションとしては,より詳細な高位分類が必要である.Zancolli分類は頚髄損傷四肢麻痺の上肢機能を細かく分類し,リハビリテーションからみても車椅子ADLが自立する可能性のあるC6を細かく分けているのは有用である.しかしマット上基本動作,移乗・移動などの動作が自立するか否かの判断に重要な肩甲帯筋群の評価がない.従来肘伸展筋である上腕三頭筋はC7髄節筋であるが,Zancolli分類ではC6髄節残存群のサブグループとしているのは混乱をまねく.そこでZancolli分類を改良し,損傷高位別の機能到達目標を決定するための評価表を作成し,ADLが自立する可能性について検討した.改良Zancolli分類でみるとC6BⅡが車椅子ADL自立の境界レベルである.
  • Ryuji Kobayashi, Naohiko Kanemura, Hiroki Kajihara, Eriko Tsutsumi, Masataka Hosoda, Akira Minematsu, Hisato Sasaki, Sachiko Tanaka, Kunji Shirahama, Junichi Shimizu, Kumiko Ono, Osamu Yoshimura
    Journal of Physical Therapy Science 13 (1) 37 - 43 0915-5287 2001 [Refereed][Not invited]
     
    In this study we try to clarify sequential changes in Meissner corpuscles after transection of the spinal cord. Meissner corpuscles stained with cholinesterase in the experimental group were already significantly fewer one week after spinal cord transection. The condition of rats in the first week after the operation was regarded as a spinal shock period. Denervation caused a decrease in the number of stained Meissner corpuscles in the shock period. In the experimental group at 7 weeks after the operation, atrophy of these corpuscles was statistically significant. These rats could not carry their weight on their hind limbs, and this change was regarded as the effect of disuse. The results of this study suggest the possibility of human sensory organs' atrophy after spinal cord injury.
  • Osamu Yoshimura, Hlroshi Maejima, Hisato Sasaki, Sachiko Tanaka, Naohiko Kanemura, Kunji Shirahama, Hiroshi Kato, Iwao Kawamoto, Hidetaka Miyamoto, Kaori Yata, Makoto Watanabe, Hideki Moriyama, Kouichi Shinkoda, Ryuji Kobayashi, Akira Minematsu, Kiyomi Takayanagi
    Journal of Physical Therapy Science 13 (2) 145 - 148 0915-5287 2001 [Refereed][Not invited]
     
    We investigated the disturbance of physical condition following evacuation of the bowels in patients with chronic cervical spinal cord injuries. The cases dealt with 17 patients who had incurred spinal cord injuries a year or more before. We measured patients' blood pressure, heart rate, and fingertip plethysmography during the evacuation procedure. Also blood pressure, heart rate and fingertip plethysmography were measured before and after the tilting test. Fourteen patients out of 17 complained about their physical condition with such complaints as feelings of exhaustion, listlessness or dizziness after evacuation. We observed a rise in blood pressure and a lowering of fingertip plethysmography during evacuation. Immediately after getting on the tilt table, these patients experienced a decrease in blood pressure and an increase in heart rate however, compared to the day before evacuation, the heart rate increase was not considered significant and the wave height for finger plethysmography was low. The strain on the sympathetic nerves due to evacuation causes autonomic dystonia which means the parasympathetic nervous system is dominant and causes impairment of circulatory function.
  • Hiroshi Maejima, Chie Kamoda, Tatehito Ueda, Hisato Sasaki, Sachiko Tanaka, Naohiko Kanemura, Akira Minematu, Osamu Yoshimura
    Journal of Physical Therapy Science 13 (2) 93 - 98 0915-5287 2001 [Refereed][Not invited]
     
    The purpose of this study was to clarify the effect of adaptation to and expectation of postural sway caused by perturbation of a platform on initial stances prior to postural response. Twenty healthy university students participated in this study. The joint angles of the ankle, knee, hip, and the neck in initial stance were measured. Adaptation to backward postural sway through repeated perturbations caused the body to tilt backward. However, expectation of backward body sway caused the body to tilt forward, compared with the initial stance when forward body sway was expected. It is suggested that expectation induces the initial stance to stabilize against postural sway mechanically prior to postural response. However, adaptation affects the efficiency of the postural response itself.
  • 慢性期脊髄損傷者の排便障害
    吉村 理, 前島 洋, 小林隆司, 峯松 亮, 佐々木久登, 田中幸子, 金村尚彦, 白浜勲二, 大隈秀信, 松尾清美, 高柳清美
    日本職業・災害医学会会誌 49 (3) 224 - 227 2001 [Refereed][Not invited]
  • 頚髄損傷者の寝返り動作と体幹回旋度の関係
    田中幸子, 吉村 理, 前島 洋, 小林隆司, 峯松 亮, 佐々木久登, 金村尚彦, 白浜勲二, 宮本英高, 矢田かおり, 渡辺 誠
    日本パラプレジア医学会雑誌 14 (1) 126 - 127 2001 [Refereed][Not invited]
  • 脊髄損傷者の排便障害
    吉村 理, 前島 洋, 小林隆司, 佐々木久登, 金村尚彦, 田中幸子, 白浜勲二, 矢田かおり, 宮本英高, 渡辺 誠, 木村浩彰, 松尾清美
    日本パラプレジア医学会雑誌 14 (1) 128 - 129 2001 [Refereed][Not invited]
  • Heterotopic ossifiation in ischium decubitus (in bursitis)
    Yoshimura O, Maejima H, Kobayashi R, Minematsu A, Sasaki H, Kanemura N, Tanaka S, Shirahama K, Takayanagi K
    Japanese Journal of Occupational Medicine and Traumatrogy 49 (2) 168 - 169 2001 [Refereed][Not invited]
  • YOSHIMURA Osamu, MAEJIMA Hiroshi, KOBAYASHI Ryuji, MINEMATSU Akira, SASAKI Hisato, TANAKA Sachiko, KANEMURA Naohiko, SHIRAHAMA Kunji, TAKAYANAGI Kiyomi, NAKAMOTO Junko
    日本職業・災害医学会会誌 49 (1) 77 - 80 1345-2592 2001 [Refereed][Not invited]
  • 転倒予防のリハビリテーション
    前島 洋
    転倒予防講演集−第1回ひろしま転倒予防セミナー 1 (1) 16 - 18 2001 [Not refereed][Not invited]
  • S Tanaka, O Yoshimura, R Kobayashi, A Minematsu, H Sasaki, H Maejima, N Kanemura, K Shirahama
    SPINAL CORD 38 (11) 683 - 686 1362-4393 2000/11 [Refereed][Not invited]
     
    Objective: To investigate the differences between traumatic tetraplegic patients who can roll and those who cannot. Design: Motion analysis using 3-dimensional measurement. Setting: Rehabilitation centers in southwestern Japan. Participants: Nineteen male participants, all of whom had traumatic C6 complete injury. Methods: We used an electromagnetic device to examine the degree of spinal movement in axial rotation during rolling (shifting from supine to side lying). This system (3-Space Win) measures the position and orientation of sensors in space. Two sensors were mounted on a subject over the spinous process of T1 and L5. Results: The spinal rotation of patients who could not roll was significantly lower than that of patients who could roll. (The average rotation of non-rollers was 31.5+/-17.5 degrees, while the average rotation of rollers was 66.3+/-17.3 degrees). In this study, there were no statistically significant differences in the members of the two groups in terms of age, height, weight or time after injury. Conclusion: Rolling requires greater and adequate flexibility in the back of tetraplegic patients.
  • 卵巣摘出モデルマウスにおける低カルシウム飼料の骨への影響
    峯松 亮, 吉村 理, 四辻 博文, 市後 博造, 高柳 清美, 小林 隆司, 細田 昌孝, 佐々木 久登, 前島 洋, 松田 佑一, 田中 幸子, 金村 尚彦, 松尾 彰久
    Journal of the Japanese Physical Therapy Association (公社)日本理学療法士協会 3 (1) 13 - 16 1344-1272 2000/05 [Not refereed][Not invited]
     
    対象は雌5週齢ICRマウス26匹で,卵巣摘出(OVX)とSHAM術を行い,各々に標準飼料(SF)又は低Ca飼料(L.Ca)を与え,術後100日目に屠殺した.左の大腿骨と脛骨の機械的強度を3点曲げ試験により算出し,乾燥後,骨重量を測定して燃焼し,灰量を調べた.大腿骨,脛骨とも機械的強度,灰量,乾燥骨重量において,有意にOVX群,L.Ca群がSHAM群,SF群よりも低値を示した.全ての値において,SHAM/SF群が最も大きい値を,OVX/L.Ca群が最も小さい値を示した.SHAM群でもL.Ca群ではSF群よりも低い値を示し,OVX群でもSF群ではL.Ca群ほどは低い値を示さなかった.機械的強度と灰量の相関については,相関係数が大腿骨,脛骨各々0.704,0.776であった.Caが骨量減少抑制,骨量維持に関与し,予防効果が期待できる
  • 動作前Silent Periodと反応時間との関係
    佐々木久登, 佐藤正子, 垣内秀雅, 長岡由樹, 石原政信, 荒井隆志, 小林隆司, 峯松 亮, 田中幸子, 松尾彰久, 金村尚彦, 白濱勲二, 上田健人, 鴨田千絵, 吉村 理, 前島 洋, 吉村 理
    広島理学療法学 9 (1) 43 - 45 2000 [Refereed][Not invited]
  • 荷重時における膝関節の回旋運動
    上田健人, 田中幸子, 小林隆司, 峯松 亮, 佐々木久登, 松尾彰久, 金村尚彦, 白濱勲二, 吉村 理, 前島 洋
    広島理学療法学 9 (1) 29 - 32 2000 [Refereed][Not invited]
  • 履き物の種類が立位姿勢に及ぼす影響について−筋電図と床反力データによる考察−
    鴨田千絵, 小林隆司, 峯松 亮, 佐々木久登, 田中幸子, 松尾彰久, 金村尚彦, 白濱勲二, 上田健人, 吉村 理, 前島 洋
    広島理学療法学 9 (1) 18 - 23 2000 [Refereed][Not invited]
  • Akira Minematsu, Osamu Yoshimura, Hirofumi Yotsuji, Hirozo Ichigo, Ryuji Kobayashi, Hisato Sasaki, Hiroshi Maejima, Sachiko Tanaka, Naohiko Kanemura, Hidetaka Miyamoto, Kunji Shirahama, Taketo Ueda, Chie Kamoda
    Journal of Physical Therapy Science 12 (2) 91 - 95 0915-5287 2000 [Refereed][Not invited]
     
    The effects of physical activity, treadmill running, on bone of ovariectomized mice were investigated. Forty 12-week-old female ICR mice were used. They were ovariectomized (OVX) or sham-operated (SHAM) and half of them were run on a treadmill at 16 m/min, 5 days/week for 6 weeks (Ex). All animals were sacrificed at week 12 after operation. Mechanical strength of the left femur and tibia were measured by the three-point bending strength test. The bones were dried, weighed and burned to ash. Mechanical strength and ash content of the femur and tibia in Ex group were significantly higher than those of control animals. Also mechanical strength of femur and tibia in OVX/Ex were not different from SHAM/Cont mice. Physical activity, treadmill running, thus affected inhibition of bone loss and maintenance of bone mass. It is necessary to continue this basic study to determine effective modes of physical activity.
  • Sachiko Tanaka, Katsuhiko Kubota, Osamu Yoshimura, Ryuji Kobayashi, Akira Minematsu, Masataka Hosoda, Hisato Sasaki, Hiroshi Maejima, Akihisa Matsuo, Naohiko Kanemura, Kunji Shirahama, Takehito Ueda, Chie Kamoda
    Journal of Physical Therapy Science 12 (2) 101 - 105 0915-5287 2000 [Refereed][Not invited]
     
    The purpose of this study was to investigate the difference between the effects of cementless and cemented total knee arthroplasty (TKA) through gait analysis. The subjects were 23 patients with osteoarthritis of the knees who were operated on with cementless TKA (average age 72.1 ± 5.0) and 25 patients with the same complaint who were operated on with cemented TKA (average age 70.7 ± 4.9). Physical therapy after surgery was the same except that in the case of cemented TKA, full weight bearing started 2 weeks earlier than for cementless TKA. Four force-plates were used to examine the knee function during customary gait. The differences before and 3 months after the operation were examined for the 2 groups and evaluated for velocity, averaged vertical component of floor reaction force (for both knees) with normalization for weight, and ratio of single support (single support time/gait cycle time) (for both knees). There was a significant difference in the ratio of single support on the non-operated side (p< 0.05). This was -3% in the case of cementless and 1% for cemented. The result was that the non-operated sides in the cementless cases were weaker than in the cemented cases. The 2 groups exhibited no significant differences on the operated side.
  • Koji Usui, Kazuyuki Tabira, Noriko Sekikawa, Osamu Yoshimura, Hiroshi Maejima, Ryuji Kobayashi, Akira Minematsu, Hisato Sasaki, Sachiko Tanaka, Naohiko Kanemura, Kunji Shirahama, Takehito Ueda, Chie Kamoda, Kiyomi Takayanagi
    Journal of Physical Therapy Science 12 (2) 119 - 124 0915-5287 2000 [Refereed][Not invited]
     
    The purpose of this study was to analyze the factors that influence health-related quality of life (HRQL) in patients with chronic respiratory failure. Subjects were seventeen patients with chronic respiratory failure. HRQL was assessed by means of the St. George's Respiratory Questionnaire (SGRQ) and the scores were compared with physiological measures, 6-minute walking distance (6MWD), activities of daily living (ADL), anxiety and depression. The mean calculated scores of each component (Symptoms, Activity, Impacts and Total) were 69.5, 73.8, 52.6 and 61.8 respectively. The SGRQ scores correlated with degree of dyspnea (the Hugh-Jones scale), vital capacity (VC), VC as percent predicted, forced expiratory volume in one second (FEV1.0), fatigue of the lower limbs, 6MWD, ADL and depression. Four separate stepwise multiple regression analyses were used to identify variables that most influence HRQL. In consequence, body-mass index, ADL, VC, FEV1.0 and 6MWD entered the equations. These findings suggest that, in order to improve HRQL, teaching adequate ADL to reduce dyspnea, training to improve exercise capacity, and to be careful with nutritional and mental status are needed.
  • Osamu Yoshimura, Tsuneji Murakami, Ryuji Kobayashi, Akira Minematsu, Hisato Sasaki, Hiroshi Maejima, Sachiko Tanaka, Naohiko Kanemura, Kunji Shirahama, Takehito Ueda, Chie Kamoda, Hidetaka Miyamoto, Kaori Yata, Makoto Watanabe, Kiyomi Takayanagi
    Journal of Physical Therapy Science 12 (2) 81 - 85 0915-5287 2000 [Refereed][Not invited]
     
    Heterotopic ossification has been reported as a complication of central nerve disorders such as spinal cord injuries and cerebral lacerations. Whenever heterotopic ossification is an associated complication, range of motion limitations arise and this makes it an important factor in the obstruction of rehabilitation. The exact cause of heterotopic ossification has not been clarified however, we do know that it is important to carry out rehabilitation, especially physical therapy exercises, such as gentle range of motion exercises, early on as a preventative measure. Subarchinoidal hemorrhage at the acute stage has several danger factors such as hemorrhage, angiospasms and hydrochephalus so there is a tendency to delay the start of rehabilitation compared to cases of cerebral infarction and cerebral hemorrhage. In this report we look at four cases of heterotopic ossification associated with subarchinoidal hemorrhage and also look at the prevention of heterotopic ossification.
  • 頚髄損傷急性期のリハビリテーション
    吉村 理, 前島 洋, 小林隆司, 峯松 亮, 佐々木久登, 田中幸子, 金村尚彦, 松尾彰久, 白濱勲二, 高柳清美
    日本職業・災害医学会会誌 48 (2) 107 - 111 2000 [Refereed][Not invited]
  • Nakano H, Mizuseki T, Yoshimura O, Kobayashi R, Minematsu A, Sasaki H, Maejima H, Tanaka S, Matsuo A, Kanemura N, Shirahama K, Ueda T, Kamoda C, Miyamoto H, Noto K, Watanabe M, Shimizu J, Takayanagi K
    Journal of Physical Therapy Science 12 (1) 33 - 38 0915-5287 2000 [Refereed][Not invited]
  • Kanemura N, Kobayashi R, Inafuku K, Hosoda M, Minematsu A, Sasaki H, Tanaka S, Shirahana K, Ueda T, Kamoda C, Miyamoto H, Maejima H, Yoshimura O
    Journal of Physical Therapy Science 理学療法科学学会 12 (1) 27 - 31 0915-5287 2000 [Refereed][Not invited]
     
    We conducted a prospective study on the actual state of fall occurrence and the related fall factors of some dementia patients admitted to a certain geriatric hospital. Information on falls was obtained from the fall assessment recorded by staff. The number of these subjects totaled 110 (20 males and 90 females), The period of this study was 6 months. Their fall rate during that period was as high as 56%. The frequently occurring places and peak time of fall coincided with the places and times slots in which their activity was enhanced. Most of the injuries suffered due to falls were minor ones, and there were no bone fractures stemming from falls. As for the factors related to a fall, sex, age, complication, MMS score and administered internal medicine was no significant between fallers and nonfallers. Of the subjects affected with cerebrovascular diseases during or before this study period, those with vascular dementia showed the most remarkable trend to fall. It was thought that the results will be useful when applied to the carried out care of elderly persons with dementia.
  • Kobayashi R, Kai N, Hosoda M, Minematsu A, Sasaki H, Maejima H, Tanaka S, Kanemura N, Shirahana K, Kamoda C, Ueda T, Noto K, Miyamoto H, Watanabe M, Shimizu J, Yoshimura O
    Journal of Physical Therapy Science 12 (1) 13 - 17 0915-5287 2000 [Refereed][Not invited]
  • クモ膜下出血に合併した異所性骨化
    吉村 理, 前島 洋, 小林隆司, 峯松 亮, 佐々木久登, 田中幸子, 金村尚彦, 松尾彰久, 白浜勲二, 高柳清美
    日本職業・災害医学会会誌 48 (3) 291 - 294 2000 [Refereed][Not invited]
  • 坐骨部 瘡・滑液包に発生した異所性骨化
    吉村 理, 前島 洋, 小林隆司, 峯松 亮, 佐々木久登, 田中幸子, 金村尚彦, 松尾彰久, 白浜勲二, 野戸かおり, 宮本英高, 渡邊 誠
    日本パラプレジア医学会雑誌 13 (1) 246 - 247 2000 [Refereed][Not invited]
  • Akira Minematsu, Osamu Yoshimura, Hirofumi Yorsuji, Hirozo Ichigo, Kiyomi Takayanagi, Ryuji Kobayashi, Masataka Hosoda, Hisato Sasaki, Hiroshi Maejima, Yuichi Matsuda, Sachiko Tanaka, Naohiko Kanemura, Akihisa Matsuo
    Journal of the Japanese Physical Therapy Association 3 (1) 13 - 16 1344-1272 2000 [Refereed][Not invited]
     
    This study investigates the effects of Ca on bone in the ovarieetomized mice. Twenty-six female ICR mice aged 5 weeks were used. They were ovarieetomized (OVX) or sham-operated (SHAM) and fed standard mouse diet (SF) or special low calcium diet (L.Ca), respectively. All animals were sacrificed at day 100 after operation. Mechanical strength of the left femur and tibia was measured by the three-point bending strength test. The bones were dried, weighed and burned to ash. Correlation between mechanical strength and ash content was found. A specimen of the right tibia was prepared. Mechanical strength, ash content and ratio of dry bone weight to body weight of the femur and tibia in OVX and L.Ca mice were significantly less than in SHAM and SF mice. SHAM/SF mice and OVX/ L.Ca group showed highest and lowest values in all cases. The values for the femur and tibia in OVX/ SF mice were lower than in SHAM/SF group and in OVX/L.Ca group were less than in OVX/SF mice. Correlation coefficients for mechanical strength and ash content were 0.704 and 0.776 for the femur and tibia. Ca is thus related to inhibition of bone loss and maintenance of bone mass and effective prevention of osteoporosis.
  • Hiroshi Maejima, Chie Kamoda, Kiyomi Takayanagi, Masataka Hosoda, Ryuji Kobayashi, Akira Minematsu, Hisato Sasaki, Yuichi Matsuda, Yukiko Tanaka, Akihisa Matsuo, Naohiko Kanemura, Tatehiko Ueda, Osamu Yoshimura
    Journal of the Japanese Physical Therapy Association 3 (1) 21 - 25 1344-1272 2000 [Refereed][Not invited]
     
    The purpose of this study was to clarify the effect of changing footwear conditions on postural response against postural perturbation. Twenty-three healthy subjects participated in this study. Postural response was induced by moving a platform forward, hereafter referred to as forwardperturbation of a platform. The center of pressure (COP) from the force plate and the electromyograms (EMG) of the tibialis anterior (TA) and quadriceps femoris (QUAD), which are both agonists of the response, were measured. The effect of plantar material and shape of footwear on postural response was examined as footwear condition. Changing plantar materials had an effect on integrated EMG of the agonists (IEMG) but not on the response pattern. On the other hand, the shape of footwear had an effect on the response pattern but not on IEMG. It was supposed from this result that changes in somatosensory input, caused by coupling of plantar material and shape of footwear, modifies postural response variously.
  • 頸髄損傷急性期のリハビリテーション
    吉村 理, 前島 洋, 小林隆司, 峯松 亮, 佐々木久登, 田中幸子, 金村尚彦, 松尾彰久, 白浜勲二, 高柳清美
    日本職業・災害医学会会誌 48 (2) 107 - 112 2000 [Refereed][Not invited]
  • 峯松亮, 吉村理, 高柳清美, 小林隆司, 細田昌孝, 佐々木久登, 前島洋
    総合リハビリテーション 医学書院 28 (4) 377 - 381 0386-9822 2000 [Not refereed][Not invited]
  • 痴呆高齢者の転倒状況と関連要因
    金村尚彦, 小林隆司, 峯松 亮, 細田昌孝, 佐々木久登, 田中幸子, 松尾彰久, 白浜勲二, 宮本英高, 矢田かおり, 吉村 理, 前島 洋, 稲福加恵
    日本職業・災害医学会 47 (12) 780 - 786 1999 [Refereed][Not invited]
  • 運動維持困難と半身妄想
    高柳清美, 小林隆司, 峯松亮, 佐々木久登, 前島洋, 松田祐一, 田中幸子, 金村尚彦, 松尾彰久
    日本災害医学会会誌 47 (12) 764 - 768 1999 [Refereed][Not invited]
  • 筋活動からみた各種動作に対する足関節装具の下腿筋群への影響―足関節捻挫予防の効果―
    峯松 亮, 吉村 理, 高柳清美, 小林隆司, 細田昌孝, 佐々木久登, 前島 洋, 田中幸子, 松尾彰久, 金村尚彦
    日本災害医学会会誌 47 (12) 775 - 779 1999 [Refereed][Not invited]
  • Akira Minematsu, Osamu Yoshimura, Kiyomi Takayanagi, Ryuji Kobayashi, Masataka Hosoda, Hisato Sasaki, Hiroshi Maejima, Sachiko Tanaka, Akihisa Matsuo, Naohiko Kanemura
    Journal of Physical Therapy Science 11 (2) 105 - 108 0915-5287 1999 [Refereed][Not invited]
     
    This study investigated the effects of the ankle brace "CREATOR" on lower extremity muscles in performances by maximum amplitudes of the integrated electromyogram (IEMG). Twelve female handball players performed four exercises, repeated side step, vertical high jump, standing long jump and pivot. Maximum amplitudes of all muscles with the brace tended to be less than those without it. Those of tibialis anterior in the repeated side step and pivot, medial gastrocnemius in all performances except for repeated side step and peroneus longus and peroneus brevis in the repeated side step were significant. Thus with the brace, subjects performed the same with less muscle activity than without it, and this brace prevented an ankle sprain against the side direction.
  • Masataka Hosoda, Osamu Yoshimura, Kiyomi Takayanagi, Hiroshi Maejima, Ryuji Kobayashi, Akira Minematsu, Hisato Sasaki, Sachiko Tanaka, Naohiko Kanemura, Yoshihiro Itou, Isao Nara, Kazuho Hosoda
    Journal of Physical Therapy Science 11 (2) 79 - 85 0915-5287 1999 [Refereed][Not invited]
     
    The motions involved in the ordinary act of walking which we all perform unthinkingly are in fact very complex and require great agility, and once impairment occurs, abnormal gait will result. The present study experimented with mechanical analysis of walking with a false leg, with a view to clinical application. Attention was focused on wave components common to the floor reaction patterns of A/K (-trans-femoral (Above Knee) amputation) and B/K (-trans-tibial (Below Knee) amputation) subjects, and waveform factors were analyzed. In this research, a VICON 3D motion analysis system was used to analyze the walking motions of A/K and B/K subjects by means of stick figure and force plate representations. Attention was focused on knee-joint movement in stick-figure analysis, and on Z-component waveforms in force plate analysis. Results showed significant differences between false leg and natural leg during mid stance in A/K subjects. Furthermore, the false leg Z-component waveforms were saw-tooth type with A/K subjects, and notch type with B/K subjects.
  • 高齢者の足指把握訓練が静的重心動揺に及ぼす影響
    小林隆司, 細田昌孝, 峯松 亮, 佐々木久登, 前島 洋, 田中幸子, 金村尚彦, 松尾彰久, 高柳清美, 吉村 理
    日本災害医学会会誌 15 (4) 633 - 636 1999 [Refereed][Not invited]
  • MATSUO Akihisa, KOBAYASHI Ryuji, MINEMATSU Akira, SASAKI Hisato, TANAKA Sachiko, KANEMURA Naohiko, YOSHIMURA Osamu, MAEJIMA Hiroshi
    Bulletin of the Japanese Society of Prosthetic and Orthotic Education, Research and Development Japanese Society of Prosthetics and Orthotics 15 (4) 321 - 323 0910-4720 1999 [Refereed][Not invited]
     
    障害者にとって自動車運転が可能かどうかは作業遂行を円滑に行うための重要な要因となりうる. 両上腕切断者では下肢で運転するオートマチック車, 両前腕切断者では義手で運転するオートマチック車を原則としている. 本稿では両上腕切断者の義手および車の改造例について両前腕切断者の例と比較し報告する.
  • Naohiko Kanemura, Ryuji Kobayashi, Masataka Hosoda, Akira Minematu, Hisato Sasaki, Hiroshi Maejima, Sachiko Tanaka, Akihisa Matuo, Kiyomi Takayanagi, Tetuo Maeda, Osamu Yoshmura
    Journal of Physical Therapy Science 11 (1) 25 - 29 0915-5287 1999 [Refereed][Not invited]
     
    The measurement of maximum voluntary isokinetic contraction is a common practice in research and clinical settings. The purpose of this study was to investigate the effect of visual feedback on muscle endurance. Subjects were 22 male, between the ages of 18 and 31. Each subject had no history of lower extremity joint injury, surgery, or disease. All subjects completed two isokinetic exercise test sessions. The tests consisted of 50 maximum voluntary isokinetic contractions, using dynamometer (KIN-COM500H) at 90 degrees per second. All left lower extremities were measured. On endurance and effects fatigue index of visual feedback and no visual feedback were compared about every tenth average peak torque. On comparisions between with and without visual feedback were analyzed using a paired t-test. On average between 11th and 20th repetitions, average peak torque with visual feedback was significantly greater than without visual feedback (p< 0.05). Excepting average torque between 11th and 20th repetition the results indicated no significant difference between with and without visual feedback. The fatigue index with feedback was not significantly different from that without visual feedback. These results suggest that visual feedback does not influence the fatigue index in measurements of muscle endurance.
  • Ryuji Kobayashi, Masataka Hosoda, Akira Minematsu, Hisato Sasaki, Hiroshi Maejima, Sachiko Tanaka, Naohiko Kanemura, Akihisa Matsuo, Kunji Shirahama, Takehito Ueda, Chie Kamoda, Osamu Yoshimura
    Journal of Physical Therapy Science 11 (1) 31 - 34 0915-5287 1999 [Refereed][Not invited]
     
    Falls are a common problem among elderly persons, but the training for the fall prevention is not well established. Therefore, the effectiveness of toe grasp training was examined in this study. Spontaneous postural sway was tested on elderly persons (N=19) with eyes open and eyes closed. Using a force plate, sway responses were quantified in terms of the total track length, the environmental areas, the maximum amplitude distance of X-axis, and the maximum amplitude distance of Y-axis. The data was compared between the toe grasp training group and the control group. Total track length (eyes open and eyes closed), environmental areas (eyes open) and maximum amplitude distance of X-axis (eyes open and eyes closed) were improved significantly in the toe grasp training group. The activation of foot mechanoreceptors and improvements of the eye-leg coordination were thought to be factors in this improvement and toe grasp training is expected to be effective for fall prevention of the aged.
  • 対麻痺の装具による歩行再建
    吉村 理, 高柳清美, 小林隆司, 峯松 亮, 佐々木久登, 前島 洋, 松田祐一, 田中幸子, 金村尚彦, 松尾彰久, 細田昌孝
    日本パラプレジア医学会誌 12 (1) 30 - 31 1999 [Refereed][Not invited]
  • 寝返りにおける動作分析(Motion Analysis of Rolling) パターン別検討
    田中幸子, 小林隆司, 峯松亮, 佐々木久登, 前島洋, 金村尚彦, 松尾彰久, 吉村理
    広島理学療法学 8 (1) 6 - 9 1999 [Refereed][Not invited]
  • YOSHIMURA Osamu, KOBAYASHI Ryuji, MINEMATSU Akira, SASAKI Hisato, MAEJIMA Hiroshi, TANAKA Sachiko, MATSUO Akihisa, KANEMURA Naohiko, SHIRAHAMA Kunji, UEDA Takehito, KAMODA Chie, TAKAYANAGI Kiyomi
    Bulletin of the Japanese Society of Prosthetic and Orthotic Education, Research and Development Japanese Society of Prosthetics and Orthotics 15 (3) 232 - 238 0910-4720 1999 [Refereed][Not invited]
  • 小林隆司, 梶原博毅, 高柳清美, 峯松 亮, 細田昌孝, 佐々木久登, 前島 洋, 松田祐一, 田中幸子, 金村尚彦, 松尾彰久, 吉村 理
    総合リハビリテーション 27 (3) 259 - 264 1999 [Refereed][Not invited]
  • 高齢痴呆者の大腿骨頸部骨折
    吉村 理, 高柳清美, 小林隆司, 峯松 亮, 細田昌孝, 佐々木久登, 前島 洋, 松田祐一, 田中幸子, 松尾彰久, 金村尚彦
    日本災害医学会会誌 47 (3) 194 - 198 1999 [Refereed][Not invited]
  • ヒトの動的立位バランス制御変化の内的・外的要因に関する運動学的研究
    前島 洋
    修士論文（広島大学） 1 - 40 1999 [Refereed][Not invited]
  • Osamu Yoshimura, Kiyomi Takayanagi, Ryuji Kobayashi, Masataka Hosoda, Akira Minematsu, Hisato Sasaki, Hiroshi Maejima, Yuiti Matsuda, Satiko Tanaka, Akihisa Matsuo, Naohiko Kanemura
    Hiroshima Journal of Medical Sciences 47 (2) 57 - 62 0018-2052 1998/06 [Refereed][Not invited]
     
    For patients with cervical spinal cord injuries to become independent in their ADL (Activities of Daily Living), residual arm function is very important. Also, age, sex, physical strength, obesity, spasticity, pain, contracture and motivation are related. We investigated the possibility of independence in ADL for patients with cervical spinal cord injuries, carrying out our evaluation based on the Zancolli Classification of Residual Arm Functions. Zancolli classification C6BII is taken as the boundary level for ADL independence. Rehabilitation is not only controlled by the patients with cervical spinal cord injuries themselves but also by the ability of the rehabilitation staff. This implies that taking responsibility in rehabilitation is important.
  • 吉村理, 高柳清美, 小林隆司, 細田昌孝, 峯松亮, 佐々木久登, 前嶋 洋, 松田祐一, 田中幸子, 金村尚彦, 松尾彰久
    総合リハビリテーション 26 (5) 459 - 465 1998/05 [Refereed][Not invited]
  • 運動維持困難と半身妄想
    吉村 理, 高柳清美, 小林隆司, 峯松 亮, 佐々木久登, 前島 洋, 松田祐一, 田中幸子, 金村尚彦, 松尾彰久
    日本災害医学会会誌 46 (12) 764 - 768 1998 [Refereed][Not invited]
  • Masataka Hosoda, Osamu Yoshimura, Kiyomi Takayanagi, Ryuji Kobayashi, Akira Minematsu, Hisato Sasaki, Hiroshi Maejima, Yuiti Matsuda, Shiho Araki, Akikazu Nakayama, Toshiro Ishibashi, Takashi Terazono
    Journal of Physical Therapy Science 10 (1) 47 - 51 0915-5287 1998 [Refereed][Not invited]
     
    Influences on dynamic balance were examined by comparing footwear with clog thongs such as slippers with clog thongs, to footwear without them such as slippers without clog thongs, leather-soled sandals, and Japanese socks. Forty three university students in good health took part in this examination. In the case of footwear with clog thongs, postural response latencies to horizontal movement of the platform were decreased when compared with that for slippers without clog thongs. In the case of footwear with clog thongs, standing strength was decreased when the platform moved horizontally, compared with that for slippers without clog thongs. Among footwear with clog thongs, in the case of Japanese socks, both latency and strength were minimal compared to slippers with clog thongs and leather-soled sandals. Therefore, it can be said that footwear with thin soles, low heels and clog thongs the most stable and the best for preventing a fall.
  • 救急救命センターでのリハビリテーションの役割―頚椎損傷の急性期管理
    吉村 理, 高柳清美, 小林隆司, 細田昌孝, 峯松 亮, 佐々木久登, 前島 洋, 松田祐一
    日本パラプレジア医学会雑誌 11 (1) 198 - 199 1998 [Refereed][Not invited]
  • 峯松 亮, 小林 隆司, 細田 昌孝, 佐々木 久登, 前島 洋, 松田 祐一, 吉村 理, 高柳 清美
    理学療法学Supplement 公益社団法人 日本理学療法士協会 1998 275 - 275 1998
  • 松田 祐一, 小林 隆二, 細田 昌孝, 峰松 亮, 佐々木 久登, 前島 洋, 吉村 理, 高柳 清美, 田平 一行
    理学療法学Supplement 公益社団法人 日本理学療法士協会 1998 132 - 132 1998
  • 前島 洋, 細田 昌孝, 峰松 亮, 小林 隆司, 佐々木 久登, 松田 祐一, 吉村 理, 高柳 清美, 吉田 勉, 坂田 清
    理学療法学Supplement 公益社団法人 日本理学療法士協会 1998 156 - 156 1998
  • 佐々木 久登, 佐藤 正子, 垣内 秀雅, 長岡 由樹, 堀 貴子, 吉村 理, 高柳 清美, 細田 昌孝, 小林 隆司, 峰松 亮, 前島 洋, 松田 祐一, 杉谷 圭子, 松田 貴子
    理学療法学Supplement 公益社団法人 日本理学療法士協会 1998 10 - 10 1998
  • リハで見逃しやすい合併症とチェックポイント一脊髄損傷編一異所性骨化
    吉村 理, 高柳清美, 小林隆司, 細田昌孝, 峯松 亮, 佐々木久登, 前島 洋, 松田祐一, 荒井隆
    臨床リハビリテーション 6 (12) 1181 - 1185 1997/12 [Not refereed][Not invited]
  • YOSHIMURA OSAMU, TAKAYANAGI KIYOMI, KOBAYASHI TAKASHI, HOSODA MASATAKA, MINEMATSU RYO, SASAKI HISATO, MAEJIMA HIROSHI, MATSUDA YUICHI
    日本義肢装具学会誌 13 76-77  0910-4720 1997/10 [Not refereed][Not invited]
  • リハで見逃しやすい合併症とチェックポイント―脊髄損傷編―異所性骨化
    吉村 理, 高柳清美, 小林隆司, 細田昌孝, 峯松 亮, 前島 洋, 松田祐一, 佐々木久登, 荒井隆志
    Journal of Clinical Rehabilitation 6 (12) 1181 - 1185 1997 [Refereed][Not invited]
  • O Yoshimura, K Takayanagi, R Kobayasi, M Hosoda, A Minematu, H Sasaki, H Maejima, Y Matsuda
    8TH WORLD CONGRESS OF THE INTERNATIONAL REHABILITATION MEDICINE ASSOCIATION (IRMA VIII), PTS 1-2 1489 - 1492 1997 [Not refereed][Not invited]
     
    Cervical spinal cord injuries to become independent in their ADL, residual arm function is very important. Also, age, sex, physical strength, obesity, spasticity, pain, contruture and motivation are related. We investigated the possibility of independence in ADL for patients with cervical spinal cord injuries carrying out our evaluation based on the Zancolli Classification of Residual Arm Functions. Zancolli classification C6BII is taken as the boundary level for ADL independence. Rehabilitation is not only controlled by the patients with cervical spinal cord injuries but also by the ability of the rehabilitation staff. This implies that taking responsibility in rehabilitation is important.

Books etc

  • 実践ストレッチ－痛みを緩和し損傷を予防する－
    高田治実, 前島 洋, 佐藤成登志 (Joint translation全頁)
    ガイアブックス 2013/03
  • エビデンスに基づいた徒手療法－問題指向型のアプローチ
    高田治実, 前島 洋, 江口英範, 佐藤成登志 (Joint translation全頁)
    産調出版 2012/12
  • リハビリテーションMOOK No. 7 義肢装具とリハビリテーション
    吉村理, 前島洋 (Joint work最新の筋電義手)
    金原出版 2003/10

MISC

  • エピジェネティクス制御を伴う有酸素運動が海馬における脳由来神経栄養因子の発現に与える影響
    北原 美佳, 井上 貴博, 萬井 太規, 高松 泰行, 前島 洋  第24回 日本基礎理学療法学会学術大会  2019/12  [Not refereed][Not invited]
  • Exercise combined with repetitive inhibition of histone deacetylases modulates the expression of neurotrophin in the cerebral cortex
    H. Maejima, M. Kitahara, T. Inoue, Y. Takamatsu  NEURO2019 (The 42nd Annual Meeting of the Japan Neuroscience Society)  2019/07  [Not refereed][Not invited]
  • Hiroshi Maejima, Naohiko Kanemura, Takanori Kokubun, Kenji Murata, Kiyomi Takayanagi  FASEB JOURNAL  31-  2017/04  [Not refereed][Not invited]
  • バランスボード上の姿勢戦略の順応効果
    萬井 太規, 長谷川 直哉, 武田 賢太, 佐藤 佑樹, 田中 晨太郎, 呉 瑕, 前島 洋, 浅賀 忠義  理学療法学  44-  (Suppl.2)  P  -1  2017/04  [Not refereed][Not invited]
  • 反復後方ステップ練習による非予測的外乱時の即時効果
    田中 晨太郎, 長谷川 直哉, 武田 賢太, 大橋 哲朗, 佐藤 祐樹, 呉 瑕, 丸谷 孝史, 金 雪梅, 萬井 太規, 前島 洋, 浅賀 忠義  理学療法学  44-  (Suppl.2)  P  -2  2017/04  [Not refereed][Not invited]
  • 金村尚彦, 村田健児, 国分貴徳, 今北英高, 武本秀徳, 森山英樹, 前島洋, 高柳清美  日本理学療法学術大会(Web)  44-  (Suppl.2)  O  -6  2017/04  [Not refereed][Not invited]
  • 口頭指示の違いが姿勢安定性と姿勢戦略に与える影響
    佐久間 萌, 長谷川 直哉, 武田 賢太, 伊吹 愛梨, 石川 啓太, 田中 晨太郎, 佐藤 祐樹, 呉 瑕, 萬井 太規, 前島 洋, 浅賀 忠義  理学療法学  43-  (Suppl.2)  P  -3  2016/10  [Not refereed][Not invited]
  • 伊吹 愛梨, 長谷川 直哉, 武田 賢太, 石川 啓太, 佐久間 萌, 佐藤 祐樹, 田中 晨太郎, 萬井 太規, 前島 洋, 浅賀 忠義  日本基礎理学療法学雑誌  20-  (1)  241  -241  2016/08  [Not refereed][Not invited]
  • 佐久間 萌, 長谷川 直哉, 武田 賢太, 伊吹 愛梨, 石川 啓太, 田中 晨太郎, 佐藤 祐樹, 呉 瑕, 萬井 太規, 前島 洋, 浅賀 忠義  日本基礎理学療法学雑誌  20-  (1)  307  -307  2016/08  [Not refereed][Not invited]
  • 佐久間 萌, 萬井 太規, 長谷川 直哉, 武田 賢太, 伊吹 愛梨, 石川 啓太, 田中 晨太郎, 佐藤 祐樹, 呉 瑕, 前島 洋, 浅賀 忠義  日本基礎理学療法学雑誌  19-  (1)  64  -64  2016/01  [Not refereed][Not invited]
  • 武田 賢太, 萬井 太規, 諏訪原 司, 長谷川 直哉, 戸塚 満久, 津田 章代, 大橋 哲朗, 趙 静, 石川 啓太, 伊吹 愛梨, 佐久間 萌, 前島 洋, 浅賀 忠義  日本基礎理学療法学雑誌  18-  (1)  65  -65  2014/11  [Not refereed][Not invited]
  • 諏訪原 司, 武田 賢太, 大橋 哲朗, 萬井 太規, 長谷川 直哉, 戸塚 満久, 津田 章代, 趙 静, 石川 啓太, 伊吹 愛梨, 佐久間 萌, 前島 洋, 浅賀 忠義  日本基礎理学療法学雑誌  18-  (1)  66  -66  2014/11  [Not refereed][Not invited]
  • 大橋 哲朗, 萬井 太規, 諏訪原 司, 佐久間 萌, 長谷川 直哉, 戸塚 満久, 津田 章代, 武田 賢太, 伊吹 愛梨, 石川 啓太, 趙 静, 前島 洋, 浅賀 忠義  日本基礎理学療法学雑誌  18-  (1)  66  -66  2014/11  [Not refereed][Not invited]
  • 前島洋, 金村尚彦, 国分貴徳, 村田健児, 高柳清美  日本理学療法学術大会(Web)  49th-  0849(J-STAGE)  2014  [Not refereed][Not invited]
  • 金村尚彦, 国分貴徳, 村田健児, 武本秀徳, 藤野努, 前島洋, 林弘之, 高柳清美  日本理学療法学術大会(Web)  49th-  0850(J-STAGE)  2014  [Not refereed][Not invited]
     
    【はじめに，目的】末梢神経損傷は，牽引，外傷，圧迫，打撲などの物理的作用によるものや 熱，電気，放射線などの様々な原因により，損傷を受け，運動。感覚麻痺などの機能的な障害が生じた状態である。支配領域にある骨格筋が部分的な除神経状態となり，退行性変成を生じる。末梢神経の効率的な再生には，神経栄養因子やサイトカインなど多くの因子が関与している事が重要であることが報告されている。末梢神経損傷に対する理学療法は，除神経によって生じる筋萎縮をできる限り予防するために，運動療法，物理療法を行う。理学療法により，損傷した末梢神経の再生にどのような影響を及ぼしているのか，不明な点も多い。本研究では，損傷した神経修復に関わる神経栄養因子やシグナ伝達系mRNA量の発現が，荷重運動介入により変化するか，運動療法の効果を基礎的観点から検証することを目的とした。【方法】Wistar系雄性ラット10週齢24匹を対象とした。①対照群（n＝6），②坐骨神経挫滅後，外乱刺激装置にて運動を4週間負荷する群（損傷後運動群；n＝6），③外乱刺激装置にて運動のみを4週間負荷する群（無処置運動群；n＝6），④坐骨神経挫滅群（損傷後非運動群；n＝6）とした。神経挫滅方法は，冷却したクリップで坐骨神経を3分間圧挫して損傷した。神経圧挫術後2日目から運動群には，運動方法は，外乱刺激装置（回転角度±7度，回転速度25rpmのプラットフォーム）を用い，期間は4週間，週に5日，1日1時間実施した。実験終了後，ラット坐骨神経を摘出し凍結保存した。坐骨神経をホモジナイザーにて粉砕後，total RNAを抽出した。cDNAの作成について，High Capacity cDNA Reverse Transcription Kit（Applied Biosystems, Foster City, CA, USA）を使用した。逆転写反応により作成したcDNAを鋳型とし，最後に神経栄養因子Nerve Growth Factor（NGF）とその受容体Tyrosinene kinase A（TrkA）,アポトーシスを阻害するphosphoinositide 3-kinase（PI3K）,Serine/threonine-specific protein kinase（Akt）のプライマーを用い，リアルタイムPCR法にてmRNA発現量を検討した。それぞれ，beta-actin mRNA発現量で正規化し，⊿⊿CT法により算出した。結果は一元配置分散分析，および多重比較検定Tukey法をおこなった。【倫理的配慮，説明と同意】本実験は，大学動物実験倫理審査委員会の承認を得て行った。【結果】NGF mRNA発現量において対照群の発現量を1とすると無処置運動群1．5倍，損傷後非運動群3．1倍，損傷後運動群2．7倍となり無処置運動群が，対照群と比較した有意に低下した（p＜0．05）。TrkA mRNA発現量は，対照群の発現量を1とすると無処置運動群0．5倍，損傷後非運動群5．2倍，損傷後運動群1．6倍となったが，有意差を認めなかった。PI3KmRNA発現量は，無処置運動群3．1倍，損傷後非運動群3．1倍，損傷後運動群2．7倍となり，損傷後非運動群が対照群より有意に増加した（p＜0．05）。Akt mRNA発現量は，対照群の発現量を1とすると，無処置運動群1．2倍，損傷後非運動群3．1倍，損傷後運動群2．7倍となり，損傷後非運動群が対照群より有意に増加した（p＜0．05）。【考察】ラットの運動機能を観察した結果，神経損傷後運動を行った群が足関節運動機能や，歩容の改善を認めた。組織観察からも髄鞘の増加が認めた。神経再生時にはグリアやSchwann細胞,標的組織より神経栄養因子が放出されるほか，神経細胞上の栄養因子受容体の発現も増加し，受容体の下流に位置する多くのの細胞内情報伝達系分子群の発現も増加する。神経細胞死を抑制する過程では，神経栄養因子，その受容体とPI3K－AktカスケードやMAPキナーゼカスケードが関与している事が明らかとなっている。本研究の結果から，NGF－TrkAとアポトーシスを阻害するPI3K－Akt経路が活性化され，神経生存維持がなされていることが示唆された。神経再生に関わる神経栄養因子やサイトカインがこの多くは，比較的な大きなポリペプチドで，神経実質内への移送系を持っていない。血行による移送は，血液神経関門によって阻まれている。神経周膜に存在する微少血管へ軸索再生に必要な物質を通過させる方法が試みられている。本研究で行った運動介入は，循環動態を改善させる効果があり，その結果運動機能が向上した可能性が示唆された。今後の課題として運動介入期間，運動負荷量，神経修復や運動機能の改善には他の因子のタンパクの解析が必要である。【理学療法学研究としての意義】末梢神経損傷に対する分子生物学的解析を行うことにより，運動療法の効果を明らかにできる可能性がある。
  • 金村尚彦, 森山英樹, 今北英高, 前島洋, 武本秀徳, 木藤伸宏, 国分貴徳, 村田健児, 五味敏昭, 高柳清美  日本理学療法学術大会(Web)  40-  (大会特別号3)  P  -014  2013/05  [Not refereed][Not invited]
  • Kiyomi Takayanagi, Naohiko Kanemura, Takanori Kokubun, Hiroshi Maejima, Yuichi Nishikawa, Hidetoshi Ihara  FASEB JOURNAL  27-  2013/04  [Not refereed][Not invited]
  • 前島洋, 金村尚彦, 国分貴徳, 村田健児, 高柳清美  日本理学療法学術大会(Web)  48th-  A-P-03(J-STAGE)  2013  [Not refereed][Not invited]
  • 国分貴徳, 金村尚彦, 藤野努, 前島洋, 森田定雄, 高柳清美  日本理学療法学術大会(Web)  48th-  C-P-23(J-STAGE)  -48101705  2013  [Not refereed][Not invited]
     
    【はじめに、目的】我々はこれまで，ラットにおいて膝前十字靭帯（以下ACL）完全損傷後に，関節の異常運動を制動することでACL完全損傷でも治癒しうることを報告し，ACL損傷後の靱帯治癒能には，損傷後における膝関節キネマティクスが関与していることを明らかにした．しかし，8週経過時点における治癒靱帯の力学的強度は正常靱帯の５割程であった．膝関節内側側副靱帯（以下MCL）の保存的治癒関するAmielら研究においては，損傷後急性期から一定期間までのCollagen type1および type3の動態が強度の回復に関与していることが報告されている．我々の先行研究においても，回復段階におけるCollagen動態が力学試験の結果に影響している可能性が免疫組織学染色により示唆されているが，詳細は不明である．そこで本研究においては，これまでに確立したACL損傷のラット保存治癒モデルを対象として，損傷後2，4，6週間経過時点においてACLを採取し，治癒経過におけるCollagen type1およびtype3のmRNA発現レベルを，real-time RT-PCR法により解析した．これらの結果から，本モデルにおける損傷後ACLの治癒に関する保護的な関節運動の効果を明らかにし，治癒を期待する運動療法を確立するための基礎となるデータを得ることが本研究の目的である．【方法】Wistar系の雄性Rat12週齢36匹をランダムに各12匹ずつ3群に振り分け，それらをそれぞれ2，4，6週群とし，更にControl群（以下Con群），Sham群，Experiment群(以下Ex群)に4匹ずつ振り分けた．ラットの右後肢を対象とし，Ex群は外科的にACLを完全に切断後，脛骨に骨孔を作成し，同部と大腿遠位部後面にナイロン糸を通してループを形成し，脛骨の前方引き出しを制動した． Sham群は，ACLは切断せず脛骨への骨孔の作成や，関節包の切開など実験群と同様の処置を行った．Con群は通常飼育とした．介入後は，ゲージ内で自由飼育し，2，4，6週経過時点で屠殺しACLを採取した．採取したACLから専用のKit(QIAGEN社)を使用してRNAを抽出した．抽出したRNAをRiboGreen RNA Assay Kitを使用してNanoDropにて定量し， High Capacity RNA to cDNA Kit(ABI社製)を使用してcDNAを合成した．合成したcDNAをもとに，Collagen type1・type3のプライマー（ABI社TaqMan Gene Expression Assay）を使用しmRNAの発現量を解析した．発現量の解析には，ΔΔCt法を用いた．【倫理的配慮、説明と同意】本研究は本学動物実験倫理委員会の承認を受け実施した．【結果】Con群の発現量を1として各群の発現量を比較した．Collagen type1の mRNA発現量は，4週経過時においてEx群で約２倍の発現量を認めた．またCollagen type3の mRNA発現量は，Ex群で2，4，6週経過の各期において発現量の増加を認めた．各群におけるCollagen type1/type3の発現量に関しては，他の2群に比べEx群においてCollagen type3の発現量が高いことが示された．【考察】我々は先行研究において，免疫組織化学染色の結果から保存的に治癒したACL実質部でCollagen type3が増加している可能性について報告したが，本研究結果はそれをmRNAレベルで支持する結果であった．この結果は，これまで報告されている損傷後の断端ACLにおけるmRNA発現に関するNegativeなデータと異なるものであり，また，MCLの保存的治癒経過におけるCollagen各typeの含有割合を報告した先行研究の結果と類似したデータを示している．以上より，受傷後早期から異常運動を制動した関節運動を行うことが，ACLの治癒においてその強度に関連するCollagen type1およびtype3の発現を促進する可能性があることが本研究により明らかとなった．今回はmRNAレベルでの発現量の分析であったが，今後タンパクレベルでの発現量の解析を行い，ACLの治癒における関節運動の効果について更なる解明を進めていく．【理学療法学研究としての意義】本研究結果は，これまで治癒しないとされてきたACL完全損傷における断端靱帯のMetabolismに関して，早期からの保護的な関節運動がPositiveな変化をもたらしうることを示した研究であり，早期からの適切な理学療法介入がACLの治癒に寄与しうることを明らかにしている．
  • 切断術後の断端管理
    前島 洋, 佐々木 久登, 森山 英樹, 金村 尚彦, 白濱 勲二, 宮本 英高, 吉村 理  日本義肢装具学会誌  18-  (1)  25  -27  2012/06  [Not refereed][Invited]
  • 前島洋, 金村尚彦, 西川裕一, 国分貴徳, 高柳清美  日本基礎理学療法学雑誌  16-  (1)  46  2012/05/08  [Not refereed][Not invited]
  • 前島洋, 金村尚彦, 西川裕一, 国分貴徳, 高柳清美  理学療法学  39-  ROMBUNNO.0455  2012  [Not refereed][Not invited]
  • Hiroshi Maejima, Ryo Kunishi, Ayumi Hamazaki, Takuya Otani, Tomoyuki Kurose, Masataka Deie  NEUROSCIENCE RESEARCH  68-  E141  -E141  2010  [Not refereed][Not invited]
  • Hiroshi Maejima, Syuhei Sakano, Takuya Otani, Tornoyuki Kurose, Masataka Deie  JOURNAL OF PHYSIOLOGICAL SCIENCES  59-  134  -134  2009  [Not refereed][Not invited]
  • 前島 洋, 砂堀 仁志, 大谷 拓哉, 坂本 望, 吉村 理, 飛松 好子  理学療法学  35-  (2)  459  -459  2008/04/20
  • 武本 秀徳, 森山 英樹, 坂 ゆかり, 大谷 拓哉, 前島 洋, 小野 武也, 前岡 美帆, 遠藤 竜治, 沖 貞明, 梶原 博毅, 飛松 好子  理学療法学  35-  (2)  2008/04/20  [Not refereed][Not invited]
  • 大谷 拓哉, 前島 洋, 飛松 好子  運動療法と物理療法 = The Journal of physical medicine  16-  (2)  89  -89  2005/06/16
  • 坂本 望, 大谷 拓哉, 松下 祐士, 坪井 鈴子, 砂堀 仁志, 前島 洋, 吉村 理, 飛松 好子  理学療法学  32-  (2)  536  -536  2005/04/20
  • 岡西 奈津子, 砂堀 仁志, 大谷 拓哉, 金島 奈緒子, 山口 知直, 高曲 宏暢, 平田 香澄, 小林 梨沙, 前島 洋, 飛松 好子, 吉村 理, 丸石 正治  理学療法学  32-  (2)  29  -29  2005/04/20
  • 金只 悠司, 前島 洋, 砂堀 仁志, 吉村 理  理学療法学  32-  (2)  79  -79  2005/04/20
  • 大谷 拓哉, 丸石 正治, 坂本 望, 川原 薫, 高曲 宏暢, 金島 奈緒子, 岡西 奈津子, 山口 知直, 金村 尚彦, 砂堀 仁志, 吉田 朋子, 前島 洋, 吉村 理, 飛松 好子  理学療法学  32-  (2)  2005/04/20  [Not refereed][Not invited]
  • 砂堀 仁志, 岡西 奈津子, 大谷 拓哉, 金村 尚彦, 稲津 恵美, 室田 和之, 立岩 康治, 前島 洋, 飛松 好子, 吉村 理, 丸石 正治  理学療法学  32-  (2)  2005/04/20  [Not refereed][Not invited]
  • 坂 ゆかり, 田原 栄俊, 竹田 弥生, 森 莉映子, 今北 英高, 森山 英樹, 前島 洋, 吉村 理, 井出 利憲, 飛松 好子  理学療法学  32-  (Suppl.2)  263  -263  2005/04  [Not refereed][Not invited]
  • H Maejima, E Kinoshita, S Issei, K Yamaoka  BIOPHYSICAL JOURNAL  88-  (1)  97A  -98A  2005/01  [Not refereed][Not invited]
  • TANAKA Sachiko, MAEJIMA Hiroshi, YOSHIMURA Osamu  Japanese journal of occupational medicine and traumatology  52-  (4)  224  -230  2004/07/01
  • 坂本 望, 松下 祐士, 立山 恵里奈, 森山 英樹, 白濱 勲二, 前島 洋, 吉村 理  理学療法学  31-  (2)  64  -64  2004/04/20
  • 前島 洋, 高石 あずさ, 金只 悠司, 砂堀 仁志, 大谷 拓哉, 坂本 望, 森山 英樹, 吉村 理  理学療法学  31-  (2)  146  -146  2004/04/20
  • 新田 春子, 白濱 勲二, 森山 英樹, 前島 洋, 吉村 理  理学療法学  31-  (2)  352  -352  2004/04/20
  • 宮本 英高, 金村 尚彦, 田中 幸子, 白濱 勲二, 森山 英樹, 霜井 哲美, 武本 秀徳, 砂堀 仁志, 坂 ゆかり, 坂本 望, 大谷 拓哉, 新田 春子, 前島 洋, 吉村 理  理学療法学  31-  (2)  2004/04/20  [Not refereed][Not invited]
  • 森山 英樹, 砂堀 仁志, 渡邉 誠, 金村 尚彦, 白濱 勲二, 今北 英高, 坂 ゆかり, 前島 洋, 吉村 理  理学療法学  31-  (Suppl.2)  3  -3  2004/04  [Not refereed][Not invited]
  • Hiroshi Maejima, Kiyohisa Takeishi, Hitoshi Sunahori, Akiko Yamawaki, Kiyomi Nakajima, Osamu Yoshimura  Journal of the Japanese Physical Therapy Association  7-  (1)  7  -14  2004  [Not refereed][Not invited]
     
    Falling due to unstable standing balance is considered to be the main cause of bone fractures, which lead elderly persons to becoming bedridden. Thus, the standing balance of elderly persons is being given increasingly greater attention. On the other hand, postural deformation caused by deformation in the spine and lower leg joints is considered to have an effect on standing balance. The objective of this study is to clarify the effect of postural deformation on the following three categories of standing balance 1) the ability to immobilize Center of Gravity (COG) in standing statically, 2) the ability to control COG during movement and 3) the postural response induced by postural sway. Fifty elderly persons (age:77.7 ± 6.4 years old, fifty females) participated in this study. Postural deformation was measured using a Spinal Mouse, a device for non-invasive measurement of spinal curvature and photographic image in sagittal plane. In line with to Nakata's classification of postural deformation, subjects were classified by extension type, S-character deformation type, flexion type, hands on the knee type and normal group. In order to assess the ability to immobilize COG in static standing, Center of Pressure (COP) in static standing was measured for 30 sec. In order to assess the ability to control COG during movement, functional reach, maximal length of stride and the period of 10 m gait were measured. Postural response was induced by fore-aft perturbation of the platform on which the subjects stood. Postural responses were assessed by measuring both COP, and electromyography (EMG) of muscles in the lower legs. There was little significant difference among the five groups concerning postural deformation in every measured item, neither in the ability to immobilize COP in static standing, nor in the postural response induced by postural sway. However, the results of measured items concerning the ability to control COG during movement were significantly worse in flexion type and hands on the knee type compared with the normal group. It was suggested that postural deformation in elderly persons effects exclusively on the ability to control COG during movement in standing balance.
  • Akira Minematsu, Osamu Yoshimura, Hiroshi Maejima, Takahide Miyamoto  Hiroshima Journal of Medical Sciences  52-  (2)  21  -25  2003/06  [Not refereed][Not invited]
     
    This study investigated the time-course of changes in bone mechanical strength in rats with spinal cord injury (SCI). Sixty-four male Wistar rats underwent spinal cord transection at the thoracic nerve. Control rats underwent a sham procedure (SHAM). Animals were sacrificed at day 1, 4, 7 and 14 after operation. The mechanical strength of the left femur and tibia was measured by the three-point bending strength test. The bones were dried, weighed and burned to ash. A specimen of right tibia was prepared and examined under a microscope. Bone mechanical strength, dry bone weight, and ash content of the femur and tibia in SCI rats were significantly lower than those in SHAM animals. Dry bone weight and ash content began to decrease from the 4th day after SCI and reached their lowest at day 7 after operation. Bone mechanical strength had reduced significantly by the 14th day. Gaps and spaces were observed in the trabecular area at the same time. After SCI, calcified cartilage decreased and the reduction of bone mass occurred rapidly. Moreover, a decline of bone mechanical strength is caused within 2 weeks. Thus, SCI led to the atrophy of bone and caused the reduction of mechanical strength at an early stage. It is thus necessary to prevent bone loss after SCI immediately.
  • Akira Minematsu, Osamu Yoshimura, Hiroshi Maejima, Takahide Miyamoto  Hiroshima Journal of Medical Sciences  52-  (2)  21  -25  2003/06  [Not refereed][Not invited]
     
    This study investigated the time-course of changes in bone mechanical strength in rats with spinal cord injury (SCI). Sixty-four male Wistar rats underwent spinal cord transection at the thoracic nerve. Control rats underwent a sham procedure (SHAM). Animals were sacrificed at day 1, 4, 7 and 14 after operation. The mechanical strength of the left femur and tibia was measured by the three-point bending strength test. The bones were dried, weighed and burned to ash. A specimen of right tibia was prepared and examined under a microscope. Bone mechanical strength, dry bone weight, and ash content of the femur and tibia in SCI rats were significantly lower than those in SHAM animals. Dry bone weight and ash content began to decrease from the 4th day after SCI and reached their lowest at day 7 after operation. Bone mechanical strength had reduced significantly by the 14th day. Gaps and spaces were observed in the trabecular area at the same time. After SCI, calcified cartilage decreased and the reduction of bone mass occurred rapidly. Moreover, a decline of bone mechanical strength is caused within 2 weeks. Thus, SCI led to the atrophy of bone and caused the reduction of mechanical strength at an early stage. It is thus necessary to prevent bone loss after SCI immediately.
  • 前島 洋, 砂堀 仁志, 森山 英樹, 国川 祥吾, 加藤 誓, 吉村 理  理学療法学  30-  (2)  233  -233  2003/04/20
  • 砂堀 仁志, 前島 洋, 武石 清久, 中島 清美, 吉村 理  理学療法学  30-  (2)  313  -313  2003/04/20
  • Hiroshi Maejima, Eiji Kinoshita, Issei Seyama, Kaoru Yamaoka  Journal of Biological Chemistry  278-  (11)  9464  -9471  2003/03/14  [Not refereed][Not invited]
     
    Grayanotoxin (GTX) exerts selective effects on voltage-dependent sodium channels by eliminating fast sodium inactivation and causing a hyperpolarizing shift in voltage dependence of channel activation. In this study, we adopted a newly developed protocol that provides independent estimates of the binding and unbinding rate constants of GTX (kon and koff) to GTX sites on the sodium channel protein, important in the molecular analysis of channel modification. Novel GTX sites were determined in D2S6 (Asn-784) and D3S6 (Ser-1276) by means of site-directed mutagenesis the results suggested that the GTX receptor consists of the S6 transmembrane segments of four homologous domains facing the ion-conducting pore. We systematically introduced at two sites in D4S6 (Nav1.4-Phe-1579 and Nav1.4-Tyr-1586) amino acid substituents with residues containing hydrophobic, aromatic, charged, or polar groups. Generally, substitutions at Phe-1579 increased both kon and koff, resulting in no prominent change in dissociation constant (Kd). It seems that the smaller the molecular size of the residue at Nav1.4-Phe-1579, the larger the rates of kon and koff, indicating that this site acts as a gate regulating access of toxin molecules to a receptor site. Substitutions at Tyr-1586 selectively increased koff but had virtually no effect on kon, thus causing a drastic increase in Kd. At position Tyr-1586, a hydrophobic or aromatic amino acid side chain was required to maintain normal sensitivity to GTX. These results suggest that the residue at position Tyr-1586 has a more critical role in mediating GTX binding than the one at position Phe-1579. Here, we propose that the affinity of GTX to Nav1.4 sodium channels might be regulated by two residues (Phe and Tyr) at positions Phe-1579 and Tyr-1586, which, respectively, control access and binding of GTX to its receptor.
  • Hiroshi Maejima, Eiji Kinoshita, Issei Seyama, Kaoru Yamaoka  Journal of Biological Chemistry  278-  (11)  9464  -9471  2003/03  [Refereed][Not invited]
     
    Grayanotoxin (GTX) exerts selective effects on voltage-dependent sodium channels by eliminating fast sodium inactivation and causing a hyperpolarizing shift in voltage dependence of channel activation. In this study, we adopted a newly developed protocol that provides independent estimates of the binding and unbinding rate constants of GTX (k(on) and k(off)) to GTX sites on the sodium channel protein, important in the molecular analysis of channel modification. Novel GTX sites were determined in D2S6 (Asn-784) and D3S6 (Ser-1276) by means of site-directed mutagenesis; the results suggested that the GTX receptor consists of the S6 transmembrane segments of four homologous domains facing the ion-conducting pore. We systematically introduced at two sites in D4S6 (Na(v)1.4-Phe-1579 and Na(v)1.4-Tyr-1586) amino acid substituents with residues containing hydrophobic, aromatic, charged, or polar groups. Generally, substitutions at Phe-1579 increased both k(on) and k(off), resulting in no prominent change in dissociation constant (K-d). It seems that the smaller the molecular size of the residue at Na(v)1.4-Phe-1579, the larger the rates of k(on) and k(off), indicating that this site acts as a gate regulating access of toxin molecules to a receptor site. Substitutions at Tyr-1586 selectively increased k(off) but had virtually no effect on k(on), thus causing a drastic increase in K-d. At position Tyr-1586, a hydrophobic or aromatic amino acid side chain was required to maintain normal sensitivity to GTX. These results suggest that the residue at position Tyr-1586 has a more critical role in mediating GTX binding than the one at position Phe-1579. Here, we propose that the affinity of GTX to Na(v)1.4 sodium channels might be regulated by two residues (Phe and Tyr) at positions Phe-1579 and Tyr-1586, which, respectively, control access and binding of to its receptor.
  • E Kinoshita, H Maejima, Seyama, I, K Yamaoka  BIOPHYSICAL JOURNAL  84-  (2)  215A  -215A  2003/02  [Not refereed][Not invited]
  • E Kinoshita, H Maejima, Seyama, I, K Yamaoka  BIOPHYSICAL JOURNAL  84-  (2)  215A  -215A  2003/02  [Not refereed][Not invited]
  • The interrelation of balance assessment in elderly people
    14th International WCPT Congress Book  2003  [Not refereed][Not invited]
  • Contractures following spinal cord injury: An experimental study in the rat
    14th International WCPT Congress Book  2003  [Not refereed][Not invited]
  • Effect of bed-environment on caregivers
    14th International WCPT  2003  [Not refereed][Not invited]
  • 異所性骨化に対する処置
    脊椎脊髄ジャーナル  16-  (4)  511  -515  2003  [Not refereed][Not invited]
  • The interrelation of balance assessment in elderly people
    14th International WCPT Congress Book  2003  [Not refereed][Not invited]
  • Contractures following spinal cord injury: An experimental study in the rat
    14th International WCPT Congress Book  2003  [Not refereed][Not invited]
  • Effect of bed-environment on caregivers
    14th International WCPT  2003  [Not refereed][Not invited]
  • H Maejima, E Kinoshita, T Yuki, M Yakehiro, Seyama, I, K Yamaoka  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS  295-  (2)  452  -457  2002/07  [Not refereed][Not invited]
     
    We located a novel binding site for grayanotoxin on the cytoplasmic linkers of voltage-dependent cardiac (rH1) or skeletal-muscle (mu1) Na+ channel isoforms (segments S4-S5 in domains D1 and D4), using the alanine scanning substitution method. GTX-modification of Na+ channels, transiently expressed in HEK 293 cells, was evaluated under whole-cell voltage clamp, from the ratio of maximum chord conductance for modified and unmodified Na+ channels. In mu1, Mutations K237A, L243A. S246A. K248A, K249A, L250A, S251A, or T1463A, caused a moderate, but statistically significant decrease in this ratio. On making corresponding mutations in rH1, only L244A dramatically reduced the ratio. Because in mu1. the serine at position 251 is the only heterologous residue with respect to rH1 (Ala-252), we made a double Mutant L243A&S251A to match the sequence of mu1 and rH1 in S4-S5 linkers of both domains. This double mutation resulted in a significant decrease in the ratio, to the same extent its L244A substitution in rH1 did, indicating that the site at Leu-244 in rH1 or at Leu-243 in mu1 is a novel one, exhibiting a synergistic effect of grayanotoxin. (C) 2002 Elsevier Science (USA). All rights reserved.
  • 前島 洋, 武石 清久, 砂堀 仁志, 中島 清見, 吉村 理  理学療法学  29-  (2)  194  -194  2002/04/20
  • 田中 幸子, 高木 憲司, 時枝 陽子, 浅野 圭司, 佐々木 久登, 金村 尚彦, 宮本 英高, 森山 英樹, 前島 洋, 吉村 理  理学療法学  29-  (2)  2002/04/20  [Not refereed][Not invited]
  • 森山 英樹, 吉田 義弘, 佐々木 久登, 田中 幸子, 金村 尚彦, 宮本 英高, 白濱 動二, 渡邉 誠, 矢田 かおり, 前島 洋, 吉村 理  理学療法学  29-  (2)  2002/04/20  [Not refereed][Not invited]
  • 金村 尚彦, 宮本 英高, 小林 隆司, 佐々木 久登, 田中 幸子, 白濱 勲二, 矢田 かおり, 渡邊 誠, 森山 英樹, 前島 洋, 吉村 理  理学療法学  29-  (2)  2002/04/20  [Not refereed][Not invited]
  • 宮本 英高, 金村 尚彦, 田中 幸子, 霜井 哲美, 佐々木 久登, 白濱 勲二, 矢田 かおり, 渡邊 誠, 森山 英樹, 前島 洋, 吉村 理  理学療法学  29-  (2)  2002/04/20  [Not refereed][Not invited]
  • H Kawagoe, K Yamaoka, E Kinoshita, Y Fujimoto, H Maejima, T Yuki, Seyama, I  FEBS LETTERS  513-  (2-3)  235  -241  2002/02  [Not refereed][Not invited]
     
    Cardiac sodium channels have been shown to have a higher sensitivity to local anesthetic agents, such as lidocaine, than the sodium channels of other tissues. To examine if this is also true for mexiletine, we have systematically measured mexiletine sensitivity of the Na channel isoforms, rH1, mu1, and rBII, which were transiently expressed in human embryonic kidney (HEK) 293 cells. We confirmed that the cardiac isoform rH1 exhibited the highest sensitivity among the three tested channel isoforms. In rH1, mu1, and rBII, the respective IC50 values were 62, 294, and 308 muM mexiletine, in regard to tonic block, and 18, 54, and 268 muM mexiletine, in relation to use (8 Hz)-dependent block. The relatively high drug sensitivity of rH1 was an invariant finding, irrespective of channel state or whether channels were subjected to infrequent or frequent depolarizing stimuli. Mutating specific amino acids in the skeletal muscle isoform mu1 (namely, mu1-I433V and mu1-S251A) to those of the cardiac isoform at putative binding sites for local anesthetic agents revealed that only one of the point mutations (mu1-S251A) has relevance to the high cardiac drug sensitivity, because mexiletine produced significantly more use-dependent and tonic block in mu1-S251A than wild-type mu1. (C) 2002 Published by Elsevier Science BY, on behalf of the Federation of European Biochemical Societies.
  • Naohiko Kanemura, Ryuji Kobayashi, Hiroki Kajihara, Akira Minematu, Hisato Sasaki, Sachiko Tanaka, Kunji Shirahama, Hidetaka Miyamoto, Makoto Watanabe, Kaori Yata, Hideki Moriyama, Hiroshi Maejima, Osamu Yoshimura  Journal of Physical Therapy Science  14-  (1)  27  -32  2002  [Not refereed][Not invited]
     
    In this study, the effect of weightlessness on mechanoreceptors in ACL was investigated in rats with hindlimb suspension. The animals used in the present study were 20 Wistar male rats (weight: 278 ± 16 g). The animals were divided into 2 groups: the Suspension group (n=10, suspended for 4 weeks) and Control group (n=10, non-suspended for 4 weeks). ACL was stained with gold chloride. The frozen section was sliced to be approximately 45 μm in thickness using a cryostat. The tissue preparations were observed through an optical microscope. Based on the criteria proposed by Freeman and Wyke, mechanoreceptor was specified and counted. Four types of nerve endings, Pacinian corpuscle, Ruffini corpuscle, Golgi tendon organ-like receptor, and free nerve ending were observed. In the Susupension group, atypical Pacinian corpuscle, and Ruffini corpuscle were observed. The number of mechanoreceptors were significantly decreased in the Suspension group (median 10) compared with the Control group (median 17) (Mann Whitney U test Z=-2.65, P< 0.01). It might be necessary to perform also to early rehabilitation to prevent the degeneration of mechanoreceptors and take into consideration the nerve control system in the clinical setting.
  • 筋放電休止期と反応時間およびバランス能力との関係
    日職災医誌  50-  (2)  145  -151  2002  [Not refereed][Not invited]
  • 高齢大腿骨頸部骨折患者の中殿筋筋電図周波数特性に関する検討
    日職災医誌  50-  (2)  107  -111  2002  [Not refereed][Not invited]
  • The analysis of binding characteristics of grayanotoxin to voltage-dependent sodium channels
    JJP  52-  (S)  115  2002  [Not refereed][Not invited]
  • On the binding property of Grayanotoxin to voltage-dependent Na channels
    JJP  52-  (S)  17  2002  [Not refereed][Not invited]
  • MATSUNARI Yuko, FUJII Tomie, MIYAKOSHI Yukiko, MAEJIMA Hiroshi, YOSHIMURA Osamu, ITO Tomoko  Japanese Journal of Health and Human Ecology  68-  (6)  216  -227  2002  [Not refereed][Not invited]
     
    In recent years, the objection has recited to carry out physical restraints. Development of new tools became pressing need. Side-supports utilize safety catches for users on the beds. The present research was conducted to examine any potential physical influence resulting from differences in adjunctive bed implements. Four women of 21-23 years old, healthy were involved. Subjects were studied for 2 days. A subject sleeps on two kinds of beds so that it may be usual. A subject's sleep level is measured using a vigilance level measurement (Bispectral Index=BIS). A BIS value is the time series. Differences in the sleep data between side rail bed conditions and side support bed conditions were evaluated with Student's t test. In all 4 subjects, the sleep data were significantly different (P<0.0o1). Correlation was shown in the sleep data in side support bed conditions among subjects. Correlation was shown in the sleep data in side rail bed conditions among subjects. The highest correlation was in side support bed. The Pearson's correlation coefficient between a case 1 and a case 2 was 0.597. This concludes that the reaction was in physiology and the body. Influence is brought to the quality of sleep of subjects according to bed conditions.
  • MATSUNARI Yuko, FUJII Tomie, MIYAKOSHI Yukiko, MAEJIMA Hiroshi, YOSHIMURA Osamu, YONEHARA Naoko, ITO Tomoko  Japanese Journal of Health and Human Ecology  68-  (5)  167  -175  2002  [Not refereed][Not invited]
     
    In 1999, the Ministry of Health, Labor and welfare produced "A Guide to Zero Body Restraint (shintai kousoku zero he no tebiki)". The Guide indicates that beds should not be surrounded by bed-fences (side-rails) that might prevent patients from getting out of bed unassisted. However, until then, side-rails had been used to maintain the comfort and safety of patients. Side-supports utilize safety catches for users on the beds. The present research was conducted to examine any potential psychological influence resulting from differences in adjunctive bed implements. Methods: A total of 31 undergraduate students from University "A" participated after providing informed consent. Two beds were prepared and side-supports were installed in one bed, and side-rails in the other. Subjects lay on a bed for 50 minutes. The Semantic Differential method was used to estimate feelings associated with use of the bed, and involved subjects completing a 15-item questionnaire. The method was then repeated for the other bed. Differences in responses between the groups were compared using the Wilcoxon matched pairs signed ranks test. Results: In the evaluation using the Semantic Differential method, difference in psychological response to side-supports and side-rails was found. Significant differences were observed for 11 of the 15 questionnaire items. The environment with the bed attached side-support displayed a more positive image than that of the side-rails bed Conclusion: A clear difference in the influence of environments was identified. Problems with bed conditions should be addressed immediately.
  • 歩行解析のメカニズムと鑑別診断: 痙性対麻痺歩行障害
    脊髄損傷ジャーナル  15-  (10)  997  -1002  2002  [Not refereed][Not invited]
  • The effect of postural deformation on standing balance in elderly person
    The 8th general assembly of Asian confederation for physical therapy  92  2002  [Not refereed][Not invited]
  • 糖尿病足の病態
    骨・関節・靭帯  15-  (1)  37  -43  2002  [Not refereed][Not invited]
  • 幻肢における最新の治療研究
    日本義肢装具学会誌  18-  (1)  62  -66  2002  [Not refereed][Not invited]
  • Hiroshi Maejima, Eiji Kinoshita, Tsunetsugu Yuki, Masuhide Yakehiro, Issei Seyama, Kaoru Yamaoka  Biochemical and Biophysical Research Communications  295-  (2)  452  -457  2002  [Not refereed][Not invited]
     
    We located a novel binding site for grayanotoxin on the cytoplasmic linkers of voltage-dependent cardiac (rH1) or skeletal-muscle (μ1) Na+ channel isoforms (segments S4-S5 in domains D1 and D4), using the alanine scanning substitution method. GTX-modification of Na+ channels, transiently expressed in HEK 293 cells, was evaluated under whole-cell voltage clamp, from the ratio of maximum chord conductance for modified and unmodified Na+ channels. In μ1, mutations K237A, L243A, S246A, K248A, K249A, L250A, S251A, or T1463A, caused a moderate, but statistically significant decrease in this ratio. On making corresponding mutations in rH1, only L244A dramatically reduced the ratio. Because in μ1, the serine at position 251 is the only heterologous residue with respect to rH1 (Ala-252), we made a double mutant L243A and S251A to match the sequence of μ1 and rH1 in S4-S5 linkers of both domains. This double mutation resulted in a significant decrease in the ratio, to the same extent as L244A substitution in rH1 did, indicating that the site at Leu-244 in rH1 or at Leu-243 in μ1 is a novel one, exhibiting a synergistic effect of grayanotoxin. © 2002 Elsevier Science Ltd. All rights reserved.
  • Naohiko Kanemura, Ryuji Kobayashi, Hiroki Kajihara, Akira Minematu, Hisato Sasaki, Sachiko Tanaka, Kunji Shirahama, Hidetaka Miyamoto, Makoto Watanabe, Kaori Yata, Hideki Moriyama, Hiroshi Maejima, Osamu Yoshimura  Journal of Physical Therapy Science  14-  (1)  27  -32  2002  [Not refereed][Not invited]
     
    In this study, the effect of weightlessness on mechanoreceptors in ACL was investigated in rats with hindlimb suspension. The animals used in the present study were 20 Wistar male rats (weight: 278 ± 16 g). The animals were divided into 2 groups: the Suspension group (n=10, suspended for 4 weeks) and Control group (n=10, non-suspended for 4 weeks). ACL was stained with gold chloride. The frozen section was sliced to be approximately 45 μm in thickness using a cryostat. The tissue preparations were observed through an optical microscope. Based on the criteria proposed by Freeman and Wyke, mechanoreceptor was specified and counted. Four types of nerve endings, Pacinian corpuscle, Ruffini corpuscle, Golgi tendon organ-like receptor, and free nerve ending were observed. In the Susupension group, atypical Pacinian corpuscle, and Ruffini corpuscle were observed. The number of mechanoreceptors were significantly decreased in the Suspension group (median 10) compared with the Control group (median 17) (Mann Whitney U test Z=-2.65, P< 0.01). It might be necessary to perform also to early rehabilitation to prevent the degeneration of mechanoreceptors and take into consideration the nerve control system in the clinical setting.
  • The analysis of binding characteristics of grayanotoxin to voltage-dependent sodium channels
    JJP  52-  (S)  115  2002  [Not refereed][Not invited]
  • On the binding property of Grayanotoxin to voltage-dependent Na channels
    JJP  52-  (S)  17  2002  [Not refereed][Not invited]
  • The effect of postural deformation on standing balance in elderly person
    The 8th general assembly of Asian confederation for physical therapy  92  2002  [Not refereed][Not invited]
  • Eiji Kinoshita, Hiroshi Maejima, Kaoru Yamaoka, Katsuhiro Konno, Nobufumi Kawai, Eisuke Shimizu, Sawana Yokote, Hitoshi Nakayama, Issei Seyama  Molecular Pharmacology  59-  (6)  1457  -1463  2001/06/01  [Refereed][Not invited]
     
    Pompilidotoxins (PMTXs), derived from the venom of solitary wasp has been known to facilitate synaptic transmission in the lobster neuromuscular junction, and a recent further study from rat trigeminal neurons revealed that the toxin slows Na+ channel inactivation without modifying activation process. Here we report that beta -PMTX modifies rat brain type II Na+ channel alpha -subunit (rBII) expressed in human embryonic kidney cells but fails to act on the rat heart alpha -subunit (rH1) at similar concentrations. We constructed a series of chimeric mutants of rBII and rH1 Na+ channels and compared modification of the steady-state Na+ currents by beta -PMTX. We found that a difference in a single amino acid between Glu-1616 in rBII and Gln-1615 in rH1 at the extracellular loop of D4S3-S4 is crucial for the action of beta -PMTX. PMTXs, which are small peptides with 13 amino acids, would be a potential tool for exploring a new functional moiety of Na+ channels.
  • E Kinoshita, H Maejima, K Yamaoka, K Konno, N Kawai, E Shimizu, S Yokote, H Nakayama, Seyama, I  MOLECULAR PHARMACOLOGY  59-  (6)  1457  -1463  2001/06  [Not refereed][Not invited]
     
    Pompilidotoxins (PMTXs), derived from the venom of solitary wasp has been known to facilitate synaptic transmission in the lobster neuromuscular junction, and a recent further study from rat trigeminal neurons revealed that the toxin slows Na+ channel inactivation without modifying activation process. Here we report that beta -PMTX modifies rat brain type II Na+ channel alpha -subunit (rBII) expressed in human embryonic kidney cells but fails to act on the rat heart alpha -subunit (rH1) at similar concentrations. We constructed a series of chimeric mutants of rBII and rH1 Na+ channels and compared modification of the steady-state Na+ currents by beta -PMTX. We found that a difference in a single amino acid between Glu-1616 in rBII and Gln-1615 in rH1 at the extracellular loop of D4S3-S4 is crucial for the action of beta -PMTX. PMTXs, which are small peptides with 13 amino acids, would be a potential tool for exploring a new functional moiety of Na+ channels.
  • 金村 尚彦, 小林 隆司, 峯松 亮, 佐々木 久登, 田中 幸子, 上田 健人, 鴨田 千絵, 宮本 英高, 前島 洋, 白濱 勲二, 吉村 理  理学療法学  28-  (2)  2001/04/20  [Not refereed][Not invited]
  • 宮本 英高, 峯松 亮, 小林 隆司, 佐々木 久登, 田中 幸子, 金村 尚彦, 白濱 勲二, 矢田 かおり, 渡邊 誠, 前島 洋, 吉村 理  理学療法学  28-  (2)  2001/04/20  [Not refereed][Not invited]
  • 前島 洋, 荒本 美和, 佐々木 久登, 上田 健人, 鴨田 千絵, 峯松 亮, 金村 尚彦, 田中 幸子, 宮本 英高, 矢田 かおり, 小瀬 奈緒美, 吉村 理  理学療法学  28-  (2)  2001/04/20  [Not refereed][Not invited]
  • 鴨田 千絵, 峯松 亮, 佐々木 久登, 田中 幸子, 金村 尚彦, 上田 健人, 宮本 英高, 前島 洋, 吉村 理  理学療法学  28-  (2)  2001/04/20  [Not refereed][Not invited]
  • 上田 健人, 前島 洋, 長谷川 正哉, 佐々木 久登, 峯松 亮, 金村 尚彦, 田中 幸子, 宮本 英高, 黒瀬 靖朗, 近藤 彰吾, 吉村 理  理学療法学  28-  (2)  2001/04/20  [Not refereed][Not invited]
  • 前島 洋, 堤 恵理子, 田中 幸子  理学療法ジャーナル  35-  (10)  753  -757  2001  [Not refereed][Not invited]
  • Looked-in症候群のリハビリテーション
    77  -80  2001  [Not refereed][Not invited]
  • Physiotherapy Canada（2000年版）まとめ
    753  -757  2001  [Not refereed][Not invited]
  • The analysis of sensitivity of S4-S5 linker in sodium channels to grayanotoxin
    Jpn. J. Physiol  51-  (S)  184  2001  [Not refereed][Not invited]
  • Osamu Yoshimura, Hlroshi Maejima, Hisato Sasaki, Sachiko Tanaka, Naohiko Kanemura, Kunji Shirahama, Hiroshi Kato, Iwao Kawamoto, Hidetaka Miyamoto, Kaori Yata, Makoto Watanabe, Hideki Moriyama, Kouichi Shinkoda, Ryuji Kobayashi, Akira Minematsu, Kiyomi Takayanagi  Journal of Physical Therapy Science  13-  (2)  145  -148  2001  [Not refereed][Not invited]
     
    We investigated the disturbance of physical condition following evacuation of the bowels in patients with chronic cervical spinal cord injuries. The cases dealt with 17 patients who had incurred spinal cord injuries a year or more before. We measured patients' blood pressure, heart rate, and fingertip plethysmography during the evacuation procedure. Also blood pressure, heart rate and fingertip plethysmography were measured before and after the tilting test. Fourteen patients out of 17 complained about their physical condition with such complaints as feelings of exhaustion, listlessness or dizziness after evacuation. We observed a rise in blood pressure and a lowering of fingertip plethysmography during evacuation. Immediately after getting on the tilt table, these patients experienced a decrease in blood pressure and an increase in heart rate however, compared to the day before evacuation, the heart rate increase was not considered significant and the wave height for finger plethysmography was low. The strain on the sympathetic nerves due to evacuation causes autonomic dystonia which means the parasympathetic nervous system is dominant and causes impairment of circulatory function.
  • Hiroshi Maejima, Chie Kamoda, Tatehito Ueda, Hisato Sasaki, Sachiko Tanaka, Naohiko Kanemura, Akira Minematu, Osamu Yoshimura  Journal of Physical Therapy Science  13-  (2)  93  -98  2001  [Not refereed][Not invited]
     
    The purpose of this study was to clarify the effect of adaptation to and expectation of postural sway caused by perturbation of a platform on initial stances prior to postural response. Twenty healthy university students participated in this study. The joint angles of the ankle, knee, hip, and the neck in initial stance were measured. Adaptation to backward postural sway through repeated perturbations caused the body to tilt backward. However, expectation of backward body sway caused the body to tilt forward, compared with the initial stance when forward body sway was expected. It is suggested that expectation induces the initial stance to stabilize against postural sway mechanically prior to postural response. However, adaptation affects the efficiency of the postural response itself.
  • Comparision between amputees of lower extremity and healthy volunteers in balance ability and premotion silent period
    ISPO2001  THP2.7  2001  [Not refereed][Not invited]
  • Effects of lateral-wedged insoles for medial osteoarthritic knees during sit-to-stand movement
    ISPO2001  TP2.3  2001  [Not refereed][Not invited]
  • The effect of lateral wedged insole on osteoarthritis of the knee
    ISPO2001  TP2.4  2001  [Not refereed][Not invited]
  • Osamu Yoshimura, Hlroshi Maejima, Hisato Sasaki, Sachiko Tanaka, Naohiko Kanemura, Kunji Shirahama, Hiroshi Kato, Iwao Kawamoto, Hidetaka Miyamoto, Kaori Yata, Makoto Watanabe, Hideki Moriyama, Kouichi Shinkoda, Ryuji Kobayashi, Akira Minematsu, Kiyomi Takayanagi  Journal of Physical Therapy Science  13-  (2)  145  -148  2001  [Not refereed][Not invited]
     
    We investigated the disturbance of physical condition following evacuation of the bowels in patients with chronic cervical spinal cord injuries. The cases dealt with 17 patients who had incurred spinal cord injuries a year or more before. We measured patients' blood pressure, heart rate, and fingertip plethysmography during the evacuation procedure. Also blood pressure, heart rate and fingertip plethysmography were measured before and after the tilting test. Fourteen patients out of 17 complained about their physical condition with such complaints as feelings of exhaustion, listlessness or dizziness after evacuation. We observed a rise in blood pressure and a lowering of fingertip plethysmography during evacuation. Immediately after getting on the tilt table, these patients experienced a decrease in blood pressure and an increase in heart rate however, compared to the day before evacuation, the heart rate increase was not considered significant and the wave height for finger plethysmography was low. The strain on the sympathetic nerves due to evacuation causes autonomic dystonia which means the parasympathetic nervous system is dominant and causes impairment of circulatory function.
  • 脊髄損傷者の排便障害
    128  -129  2001  [Not refereed][Not invited]
  • 頚髄損傷者の寝返り動作と体幹回旋度の関係
    126  -127  2001  [Not refereed][Not invited]
  • Heterotopic ossifiation in ischium decubitus (in bursitis)
    日職災医誌  168  -169  2001  [Not refereed][Not invited]
  • 慢性期脊髄損傷者の排便障害
    224  -227  2001  [Not refereed][Not invited]
  • The analysis of sensitivity of S4-S5 linker in sodium channels to grayanotoxin
    Jpn. J. Physiol  51-  (S)  184  2001  [Not refereed][Not invited]
  • Osamu Yoshimura, Hlroshi Maejima, Hisato Sasaki, Sachiko Tanaka, Naohiko Kanemura, Kunji Shirahama, Hiroshi Kato, Iwao Kawamoto, Hidetaka Miyamoto, Kaori Yata, Makoto Watanabe, Hideki Moriyama, Kouichi Shinkoda, Ryuji Kobayashi, Akira Minematsu, Kiyomi Takayanagi  Journal of Physical Therapy Science  13-  (2)  145  -148  2001  [Not refereed][Not invited]
     
    We investigated the disturbance of physical condition following evacuation of the bowels in patients with chronic cervical spinal cord injuries. The cases dealt with 17 patients who had incurred spinal cord injuries a year or more before. We measured patients' blood pressure, heart rate, and fingertip plethysmography during the evacuation procedure. Also blood pressure, heart rate and fingertip plethysmography were measured before and after the tilting test. Fourteen patients out of 17 complained about their physical condition with such complaints as feelings of exhaustion, listlessness or dizziness after evacuation. We observed a rise in blood pressure and a lowering of fingertip plethysmography during evacuation. Immediately after getting on the tilt table, these patients experienced a decrease in blood pressure and an increase in heart rate however, compared to the day before evacuation, the heart rate increase was not considered significant and the wave height for finger plethysmography was low. The strain on the sympathetic nerves due to evacuation causes autonomic dystonia which means the parasympathetic nervous system is dominant and causes impairment of circulatory function.
  • Hiroshi Maejima, Chie Kamoda, Tatehito Ueda, Hisato Sasaki, Sachiko Tanaka, Naohiko Kanemura, Akira Minematu, Osamu Yoshimura  Journal of Physical Therapy Science  13-  (2)  93  -98  2001  [Not refereed][Not invited]
     
    The purpose of this study was to clarify the effect of adaptation to and expectation of postural sway caused by perturbation of a platform on initial stances prior to postural response. Twenty healthy university students participated in this study. The joint angles of the ankle, knee, hip, and the neck in initial stance were measured. Adaptation to backward postural sway through repeated perturbations caused the body to tilt backward. However, expectation of backward body sway caused the body to tilt forward, compared with the initial stance when forward body sway was expected. It is suggested that expectation induces the initial stance to stabilize against postural sway mechanically prior to postural response. However, adaptation affects the efficiency of the postural response itself.
  • Comparision between amputees of lower extremity and healthy volunteers in balance ability and premotion silent period
    ISPO2001  THP2.7  2001  [Not refereed][Not invited]
  • Effects of lateral-wedged insoles for medial osteoarthritic knees during sit-to-stand movement
    ISPO2001  TP2.3  2001  [Not refereed][Not invited]
  • The effect of lateral wedged insole on osteoarthritis of the knee
    ISPO2001  TP2.4  2001  [Not refereed][Not invited]
  • Osamu Yoshimura, Hlroshi Maejima, Hisato Sasaki, Sachiko Tanaka, Naohiko Kanemura, Kunji Shirahama, Hiroshi Kato, Iwao Kawamoto, Hidetaka Miyamoto, Kaori Yata, Makoto Watanabe, Hideki Moriyama, Kouichi Shinkoda, Ryuji Kobayashi, Akira Minematsu, Kiyomi Takayanagi  Journal of Physical Therapy Science  13-  (2)  145  -148  2001  [Not refereed][Not invited]
     
    We investigated the disturbance of physical condition following evacuation of the bowels in patients with chronic cervical spinal cord injuries. The cases dealt with 17 patients who had incurred spinal cord injuries a year or more before. We measured patients' blood pressure, heart rate, and fingertip plethysmography during the evacuation procedure. Also blood pressure, heart rate and fingertip plethysmography were measured before and after the tilting test. Fourteen patients out of 17 complained about their physical condition with such complaints as feelings of exhaustion, listlessness or dizziness after evacuation. We observed a rise in blood pressure and a lowering of fingertip plethysmography during evacuation. Immediately after getting on the tilt table, these patients experienced a decrease in blood pressure and an increase in heart rate however, compared to the day before evacuation, the heart rate increase was not considered significant and the wave height for finger plethysmography was low. The strain on the sympathetic nerves due to evacuation causes autonomic dystonia which means the parasympathetic nervous system is dominant and causes impairment of circulatory function.
  • Heterotopic ossifiation in ischium decubitus (in bursitis)
    168  -169  2001  [Not refereed][Not invited]
  • S Tanaka, O Yoshimura, R Kobayashi, A Minematsu, H Sasaki, H Maejima, N Kanemura, K Shirahama  SPINAL CORD  38-  (11)  683  -686  2000/11  [Not refereed][Not invited]
     
    Objective: To investigate the differences between traumatic tetraplegic patients who can roll and those who cannot. Design: Motion analysis using 3-dimensional measurement. Setting: Rehabilitation centers in southwestern Japan. Participants: Nineteen male participants, all of whom had traumatic C6 complete injury. Methods: We used an electromagnetic device to examine the degree of spinal movement in axial rotation during rolling (shifting from supine to side lying). This system (3-Space Win) measures the position and orientation of sensors in space. Two sensors were mounted on a subject over the spinous process of T1 and L5. Results: The spinal rotation of patients who could not roll was significantly lower than that of patients who could roll. (The average rotation of non-rollers was 31.5+/-17.5 degrees, while the average rotation of rollers was 66.3+/-17.3 degrees). In this study, there were no statistically significant differences in the members of the two groups in terms of age, height, weight or time after injury. Conclusion: Rolling requires greater and adequate flexibility in the back of tetraplegic patients.
  • 佐々木 久登, 佐藤 正子, 垣内 秀雄, 長岡 由樹, 石原 政信, 前島 洋, 吉村 理, 峰松 亮, 田中 幸子, 金村 尚彦, 上田 健人, 鴨田 千絵  理学療法学  27-  (2)  2000/04/20  [Not refereed][Not invited]
  • 前島 洋, 鴨田 千絵, 小林 隆司, 峯松 亮, 佐々木 久登, 田中 幸子, 金村 尚彦, 松尾 彰久, 白浜 勲二, 上田 健人, 吉村 理  理学療法学  27-  (2)  2000/04/20  [Not refereed][Not invited]
  • 上田 健人, 田中 幸子, 小林 隆司, 峯松 亮, 佐々木 久登, 松尾 彰久, 金村 尚彦, 白濱 勲二, 鴨田 千絵, 前島 洋, 吉村 埋  理学療法学  27-  (2)  2000/04/20  [Not refereed][Not invited]
  • 鴨田 千絵, 前島 洋, 小林 隆司, 峯松 亮, 佐々木 久登, 田中 幸子, 松尾 彰久, 金村 尚彦, 白濱 勲二, 上田 健人, 野呂 陽子, 吉村 理  理学療法学  27-  (2)  2000/04/20  [Not refereed][Not invited]
  • 峯松 亮, 吉村 理, 高柳 清美, 小林 隆司, 細田 昌孝, 佐々木 久登, 前島 洋, 田中 幸子, 松尾 彰久, 金村 尚彦, 白濱 勲二, 上田 健人, 鴨田 千絵, 宮本 英高  理学療法学  27-  (2)  2000/04/20  [Not refereed][Not invited]
  • 田中 幸子, 高木 憲司, 時枝 陽子, 浅野 圭司, 岡崎 満樹, 中野 博美, 吉村 理, 前島 洋, 小林 隆司, 峯松 亮, 細田 昌孝, 佐々木 久登, 松尾 彰久, 金村 尚彦, 白濱 勲二, 鴨田 千絵, 上田 健人  理学療法学  27-  (2)  2000/04/20  [Not refereed][Not invited]
  • 金村 尚彦, 小林 隆司, 峯松 亮, 佐々木 久登, 田中 幸子, 松尾 彰久, 白濱 勲二, 鴨田 千絵, 上田 健人, 前島 洋, 吉村 理  理学療法学  27-  (2)  2000/04/20  [Not refereed][Not invited]
  • KANEMURA NAOHIKO, KOBAYASHI RYUJI, INAFUKU KAE, HOSODA MASATAKA, MINEMATSU AKIRA, SASAKI HISATO, TANAKA SACHIKO, SHIRAHAMA KUNJI, UEDA TAKEHITO, KAMODA CHIE, MIYAMOTO HIDETAKA, MAEJIMA HIROSHI, YOSHIMURA OSAMU  Journal of Physical Therapy Science  12-  (1)  27  -31  2000  [Not refereed][Not invited]
     
    We conducted a prospective study on the actual state of fall occurrence and the related fall factors of some dementia patients admitted to a certain geriatric hospital. Information on falls was obtained from the fall assessment recorded by staff. The number of these subjects totaled 110 (20 males and 90 females), The period of this study was 6 months. Their fall rate during that period was as high as 56%. The frequently occurring places and peak time of fall coincided with the places and times slots in which their activity was enhanced. Most of the injuries suffered due to falls were minor ones, and there were no bone fractures stemming from falls. As for the factors related to a fall, sex, age, complication, MMS score and administered internal medicine was no significant between fallers and nonfallers. Of the subjects affected with cerebrovascular diseases during or before this study period, those with vascular dementia showed the most remarkable trend to fall. It was thought that the results will be useful when applied to the carried out care of elderly persons with dementia.
  • Akira Minematsu, Osamu Yoshimura, Hirofumi Yotsuji, Hirozo Ichigo, Ryuji Kobayashi, Hisato Sasaki, Hiroshi Maejima, Sachiko Tanaka, Naohiko Kanemura, Hidetaka Miyamoto, Kunji Shirahama, Taketo Ueda, Chie Kamoda  Journal of Physical Therapy Science  12-  (2)  91  -95  2000  [Not refereed][Not invited]
     
    The effects of physical activity, treadmill running, on bone of ovariectomized mice were investigated. Forty 12-week-old female ICR mice were used. They were ovariectomized (OVX) or sham-operated (SHAM) and half of them were run on a treadmill at 16 m/min, 5 days/week for 6 weeks (Ex). All animals were sacrificed at week 12 after operation. Mechanical strength of the left femur and tibia were measured by the three-point bending strength test. The bones were dried, weighed and burned to ash. Mechanical strength and ash content of the femur and tibia in Ex group were significantly higher than those of control animals. Also mechanical strength of femur and tibia in OVX/Ex were not different from SHAM/Cont mice. Physical activity, treadmill running, thus affected inhibition of bone loss and maintenance of bone mass. It is necessary to continue this basic study to determine effective modes of physical activity.
  • Koji Usui, Kazuyuki Tabira, Noriko Sekikawa, Osamu Yoshimura, Hiroshi Maejima, Ryuji Kobayashi, Akira Minematsu, Hisato Sasaki, Sachiko Tanaka, Naohiko Kanemura, Kunji Shirahama, Takehito Ueda, Chie Kamoda, Kiyomi Takayanagi  Journal of Physical Therapy Science  12-  (2)  119  -124  2000  [Not refereed][Not invited]
     
    The purpose of this study was to analyze the factors that influence health-related quality of life (HRQL) in patients with chronic respiratory failure. Subjects were seventeen patients with chronic respiratory failure. HRQL was assessed by means of the St. George's Respiratory Questionnaire (SGRQ) and the scores were compared with physiological measures, 6-minute walking distance (6MWD), activities of daily living (ADL), anxiety and depression. The mean calculated scores of each component (Symptoms, Activity, Impacts and Total) were 69.5, 73.8, 52.6 and 61.8 respectively. The SGRQ scores correlated with degree of dyspnea (the Hugh-Jones scale), vital capacity (VC), VC as percent predicted, forced expiratory volume in one second (FEV1.0), fatigue of the lower limbs, 6MWD, ADL and depression. Four separate stepwise multiple regression analyses were used to identify variables that most influence HRQL. In consequence, body-mass index, ADL, VC, FEV1.0 and 6MWD entered the equations. These findings suggest that, in order to improve HRQL, teaching adequate ADL to reduce dyspnea, training to improve exercise capacity, and to be careful with nutritional and mental status are needed.
  • Seyama, I, E Kinoshita, H Maejima, K Yamaoka, N Kawai  BIOPHYSICAL JOURNAL  78-  (1)  172A  -172A  2000/01  [Not refereed][Not invited]
  • Hiroshi Maejima, Chie Kamoda, Kiyomi Takayanagi, Masataka Hosoda, Ryuji Kobayashi, Akira Minematsu, Hisato Sasaki, Yuichi Matsuda, Yukiko Tanaka, Akihisa Matsuo, Naohiko Kanemura, Tatehiko Ueda, Osamu Yoshimura  Journal of the Japanese Physical Therapy Association  3-  (1)  21  -25  2000  [Not refereed][Not invited]
     
    The purpose of this study was to clarify the effect of changing footwear conditions on postural response against postural perturbation. Twenty-three healthy subjects participated in this study. Postural response was induced by moving a platform forward, hereafter referred to as forwardperturbation of a platform. The center of pressure (COP) from the force plate and the electromyograms (EMG) of the tibialis anterior (TA) and quadriceps femoris (QUAD), which are both agonists of the response, were measured. The effect of plantar material and shape of footwear on postural response was examined as footwear condition. Changing plantar materials had an effect on integrated EMG of the agonists (IEMG) but not on the response pattern. On the other hand, the shape of footwear had an effect on the response pattern but not on IEMG. It was supposed from this result that changes in somatosensory input, caused by coupling of plantar material and shape of footwear, modifies postural response variously.
  • 坐骨部 瘡・滑液包に発生した異所性骨化
    246  -247  2000  [Not refereed][Not invited]
  • 頸髄損傷急性期のリハビリテーション
    107  -112  2000  [Not refereed][Not invited]
  • Ryuji Kobayashi, Nami Kai, Masataka Hosoda, Akira Minematsu, Hisato Sasaki, Hiroshi Maejima, Sachiko Tanaka, Naohiko Kanemura, Kunji Shirahama, Chie Kamoda, Takehito Ueda, Kaori Noto, Hidetaka Miyamoto, Makoto Watanabe, Junichi Shimizu, Osamu Yoshimura  Journal of Physical Therapy Science  12-  (1)  13  -17  2000  [Not refereed][Not invited]
  • KANEMURA NAOHIKO, KOBAYASHI RYUJI, INAFUKU KAE, HOSODA MASATAKA, MINEMATSU AKIRA, SASAKI HISATO, TANAKA SACHIKO, SHIRAHAMA KUNJI, UEDA TAKEHITO, KAMODA CHIE, MIYAMOTO HIDETAKA, MAEJIMA HIROSHI, YOSHIMURA OSAMU  Journal of Physical Therapy Science  12-  (1)  27  -31  2000  [Not refereed][Not invited]
     
    We conducted a prospective study on the actual state of fall occurrence and the related fall factors of some dementia patients admitted to a certain geriatric hospital. Information on falls was obtained from the fall assessment recorded by staff. The number of these subjects totaled 110 (20 males and 90 females), The period of this study was 6 months. Their fall rate during that period was as high as 56%. The frequently occurring places and peak time of fall coincided with the places and times slots in which their activity was enhanced. Most of the injuries suffered due to falls were minor ones, and there were no bone fractures stemming from falls. As for the factors related to a fall, sex, age, complication, MMS score and administered internal medicine was no significant between fallers and nonfallers. Of the subjects affected with cerebrovascular diseases during or before this study period, those with vascular dementia showed the most remarkable trend to fall. It was thought that the results will be useful when applied to the carried out care of elderly persons with dementia.
  • KANEMURA NAOHIKO, KOBAYASHI RYUJI, INAFUKU KAE, HOSODA MASATAKA, MINEMATSU AKIRA, SASAKI HISATO, TANAKA SACHIKO, SHIRAHAMA KUNJI, UEDA TAKEHITO, KAMODA CHIE, MIYAMOTO HIDETAKA, MAEJIMA HIROSHI, YOSHIMURA OSAMU  Journal of Physical Therapy Science  12-  (1)  27  -31  2000  [Not refereed][Not invited]
     
    We conducted a prospective study on the actual state of fall occurrence and the related fall factors of some dementia patients admitted to a certain geriatric hospital. Information on falls was obtained from the fall assessment recorded by staff. The number of these subjects totaled 110 (20 males and 90 females), The period of this study was 6 months. Their fall rate during that period was as high as 56%. The frequently occurring places and peak time of fall coincided with the places and times slots in which their activity was enhanced. Most of the injuries suffered due to falls were minor ones, and there were no bone fractures stemming from falls. As for the factors related to a fall, sex, age, complication, MMS score and administered internal medicine was no significant between fallers and nonfallers. Of the subjects affected with cerebrovascular diseases during or before this study period, those with vascular dementia showed the most remarkable trend to fall. It was thought that the results will be useful when applied to the carried out care of elderly persons with dementia.
  • Hiromi Nakano, Takaya Mizuseki, Osamu Yoshimura, Ryuji Kobayashi, Akira Minematsu, Hisato Sasaki, Hiroshi Maejima, Sachiko Tanaka, Akihisa Matsuo, Naohiko Kanemura, Kunji Shirahama, Takehito Ueda, Chie Kamoda, Hidetaka Miyamoto, Kaori Noto, Makoto Watanabe, Junichi Shimizu, Kiyomi Takayanagi  Journal of Physical Therapy Science  12-  (1)  33  -38  2000  [Not refereed][Not invited]
  • クモ膜下出血に合併した異所性骨化
    291  -294  2000  [Not refereed][Not invited]
  • Sachiko Tanaka, Katsuhiko Kubota, Osamu Yoshimura, Ryuji Kobayashi, Akira Minematsu, Masataka Hosoda, Hisato Sasaki, Hiroshi Maejima, Akihisa Matsuo, Naohiko Kanemura, Kunji Shirahama, Takehito Ueda, Chie Kamoda  Journal of Physical Therapy Science  12-  (2)  101  -105  2000  [Not refereed][Not invited]
     
    The purpose of this study was to investigate the difference between the effects of cementless and cemented total knee arthroplasty (TKA) through gait analysis. The subjects were 23 patients with osteoarthritis of the knees who were operated on with cementless TKA (average age 72.1 ± 5.0) and 25 patients with the same complaint who were operated on with cemented TKA (average age 70.7 ± 4.9). Physical therapy after surgery was the same except that in the case of cemented TKA, full weight bearing started 2 weeks earlier than for cementless TKA. Four force-plates were used to examine the knee function during customary gait. The differences before and 3 months after the operation were examined for the 2 groups and evaluated for velocity, averaged vertical component of floor reaction force (for both knees) with normalization for weight, and ratio of single support (single support time/gait cycle time) (for both knees). There was a significant difference in the ratio of single support on the non-operated side (p< 0.05). This was -3% in the case of cementless and 1% for cemented. The result was that the non-operated sides in the cementless cases were weaker than in the cemented cases. The 2 groups exhibited no significant differences on the operated side.
  • KANEMURA NAOHIKO, KOBAYASHI RYUJI, INAFUKU KAE, HOSODA MASATAKA, MINEMATSU AKIRA, SASAKI HISATO, TANAKA SACHIKO, SHIRAHAMA KUNJI, UEDA TAKEHITO, KAMODA CHIE, MIYAMOTO HIDETAKA, MAEJIMA HIROSHI, YOSHIMURA OSAMU  J Phys Ther Sci  12-  (1)  27  -31  2000  [Not refereed][Not invited]
     
    We conducted a prospective study on the actual state of fall occurrence and the related fall factors of some dementia patients admitted to a certain geriatric hospital. Information on falls was obtained from the fall assessment recorded by staff. The number of these subjects totaled 110 (20 males and 90 females), The period of this study was 6 months. Their fall rate during that period was as high as 56%. The frequently occurring places and peak time of fall coincided with the places and times slots in which their activity was enhanced. Most of the injuries suffered due to falls were minor ones, and there were no bone fractures stemming from falls. As for the factors related to a fall, sex, age, complication, MMS score and administered internal medicine was no significant between fallers and nonfallers. Of the subjects affected with cerebrovascular diseases during or before this study period, those with vascular dementia showed the most remarkable trend to fall. It was thought that the results will be useful when applied to the carried out care of elderly persons with dementia.
  • Akira Minematsu, Osamu Yoshimura, Hirofumi Yotsuji, Hirozo Ichigo, Ryuji Kobayashi, Hisato Sasaki, Hiroshi Maejima, Sachiko Tanaka, Naohiko Kanemura, Hidetaka Miyamoto, Kunji Shirahama, Taketo Ueda, Chie Kamoda  Journal of Physical Therapy Science  12-  (2)  91  -95  2000  [Not refereed][Not invited]
     
    The effects of physical activity, treadmill running, on bone of ovariectomized mice were investigated. Forty 12-week-old female ICR mice were used. They were ovariectomized (OVX) or sham-operated (SHAM) and half of them were run on a treadmill at 16 m/min, 5 days/week for 6 weeks (Ex). All animals were sacrificed at week 12 after operation. Mechanical strength of the left femur and tibia were measured by the three-point bending strength test. The bones were dried, weighed and burned to ash. Mechanical strength and ash content of the femur and tibia in Ex group were significantly higher than those of control animals. Also mechanical strength of femur and tibia in OVX/Ex were not different from SHAM/Cont mice. Physical activity, treadmill running, thus affected inhibition of bone loss and maintenance of bone mass. It is necessary to continue this basic study to determine effective modes of physical activity.
  • Koji Usui, Kazuyuki Tabira, Noriko Sekikawa, Osamu Yoshimura, Hiroshi Maejima, Ryuji Kobayashi, Akira Minematsu, Hisato Sasaki, Sachiko Tanaka, Naohiko Kanemura, Kunji Shirahama, Takehito Ueda, Chie Kamoda, Kiyomi Takayanagi  Journal of Physical Therapy Science  12-  (2)  119  -124  2000  [Not refereed][Not invited]
     
    The purpose of this study was to analyze the factors that influence health-related quality of life (HRQL) in patients with chronic respiratory failure. Subjects were seventeen patients with chronic respiratory failure. HRQL was assessed by means of the St. George's Respiratory Questionnaire (SGRQ) and the scores were compared with physiological measures, 6-minute walking distance (6MWD), activities of daily living (ADL), anxiety and depression. The mean calculated scores of each component (Symptoms, Activity, Impacts and Total) were 69.5, 73.8, 52.6 and 61.8 respectively. The SGRQ scores correlated with degree of dyspnea (the Hugh-Jones scale), vital capacity (VC), VC as percent predicted, forced expiratory volume in one second (FEV1.0), fatigue of the lower limbs, 6MWD, ADL and depression. Four separate stepwise multiple regression analyses were used to identify variables that most influence HRQL. In consequence, body-mass index, ADL, VC, FEV1.0 and 6MWD entered the equations. These findings suggest that, in order to improve HRQL, teaching adequate ADL to reduce dyspnea, training to improve exercise capacity, and to be careful with nutritional and mental status are needed.
  • Hiroshi Maejima, Chie Kamoda, Kiyomi Takayanagi, Masataka Hosoda, Ryuji Kobayashi, Akira Minematsu, Hisato Sasaki, Yuichi Matsuda, Yukiko Tanaka, Akihisa Matsuo, Naohiko Kanemura, Tatehiko Ueda, Osamu Yoshimura  Journal of the Japanese Physical Therapy Association  3-  (1)  21  -25  2000  [Not refereed][Not invited]
     
    The purpose of this study was to clarify the effect of changing footwear conditions on postural response against postural perturbation. Twenty-three healthy subjects participated in this study. Postural response was induced by moving a platform forward, hereafter referred to as forwardperturbation of a platform. The center of pressure (COP) from the force plate and the electromyograms (EMG) of the tibialis anterior (TA) and quadriceps femoris (QUAD), which are both agonists of the response, were measured. The effect of plantar material and shape of footwear on postural response was examined as footwear condition. Changing plantar materials had an effect on integrated EMG of the agonists (IEMG) but not on the response pattern. On the other hand, the shape of footwear had an effect on the response pattern but not on IEMG. It was supposed from this result that changes in somatosensory input, caused by coupling of plantar material and shape of footwear, modifies postural response variously.
  • Ryuji Kobayashi, Nami Kai, Masataka Hosoda, Akira Minematsu, Hisato Sasaki, Hiroshi Maejima, Sachiko Tanaka, Naohiko Kanemura, Kunji Shirahama, Chie Kamoda, Takehito Ueda, Kaori Noto, Hidetaka Miyamoto, Makoto Watanabe, Junichi Shimizu, Osamu Yoshimura  J Phys Ther Sci  12-  (1)  13  -17  2000  [Not refereed][Not invited]
  • KANEMURA NAOHIKO, KOBAYASHI RYUJI, INAFUKU KAE, HOSODA MASATAKA, MINEMATSU AKIRA, SASAKI HISATO, TANAKA SACHIKO, SHIRAHAMA KUNJI, UEDA TAKEHITO, KAMODA CHIE, MIYAMOTO HIDETAKA, MAEJIMA HIROSHI, YOSHIMURA OSAMU  J Phys Ther Sci  12-  (1)  27  -31  2000  [Not refereed][Not invited]
     
    We conducted a prospective study on the actual state of fall occurrence and the related fall factors of some dementia patients admitted to a certain geriatric hospital. Information on falls was obtained from the fall assessment recorded by staff. The number of these subjects totaled 110 (20 males and 90 females), The period of this study was 6 months. Their fall rate during that period was as high as 56%. The frequently occurring places and peak time of fall coincided with the places and times slots in which their activity was enhanced. Most of the injuries suffered due to falls were minor ones, and there were no bone fractures stemming from falls. As for the factors related to a fall, sex, age, complication, MMS score and administered internal medicine was no significant between fallers and nonfallers. Of the subjects affected with cerebrovascular diseases during or before this study period, those with vascular dementia showed the most remarkable trend to fall. It was thought that the results will be useful when applied to the carried out care of elderly persons with dementia.
  • KANEMURA NAOHIKO, KOBAYASHI RYUJI, INAFUKU KAE, HOSODA MASATAKA, MINEMATSU AKIRA, SASAKI HISATO, TANAKA SACHIKO, SHIRAHAMA KUNJI, UEDA TAKEHITO, KAMODA CHIE, MIYAMOTO HIDETAKA, MAEJIMA HIROSHI, YOSHIMURA OSAMU  J Phys Ther Sci  12-  (1)  27  -31  2000  [Not refereed][Not invited]
     
    We conducted a prospective study on the actual state of fall occurrence and the related fall factors of some dementia patients admitted to a certain geriatric hospital. Information on falls was obtained from the fall assessment recorded by staff. The number of these subjects totaled 110 (20 males and 90 females), The period of this study was 6 months. Their fall rate during that period was as high as 56%. The frequently occurring places and peak time of fall coincided with the places and times slots in which their activity was enhanced. Most of the injuries suffered due to falls were minor ones, and there were no bone fractures stemming from falls. As for the factors related to a fall, sex, age, complication, MMS score and administered internal medicine was no significant between fallers and nonfallers. Of the subjects affected with cerebrovascular diseases during or before this study period, those with vascular dementia showed the most remarkable trend to fall. It was thought that the results will be useful when applied to the carried out care of elderly persons with dementia.
  • Hiromi Nakano, Takaya Mizuseki, Osamu Yoshimura, Ryuji Kobayashi, Akira Minematsu, Hisato Sasaki, Hiroshi Maejima, Sachiko Tanaka, Akihisa Matsuo, Naohiko Kanemura, Kunji Shirahama, Takehito Ueda, Chie Kamoda, Hidetaka Miyamoto, Kaori Noto, Makoto Watanabe, Junichi Shimizu, Kiyomi Takayanagi  J Phys Ther Sci  12-  (1)  33  -38  2000  [Not refereed][Not invited]
  • Sachiko Tanaka, Katsuhiko Kubota, Osamu Yoshimura, Ryuji Kobayashi, Akira Minematsu, Masataka Hosoda, Hisato Sasaki, Hiroshi Maejima, Akihisa Matsuo, Naohiko Kanemura, Kunji Shirahama, Takehito Ueda, Chie Kamoda  Journal of Physical Therapy Science  12-  (2)  101  -105  2000  [Not refereed][Not invited]
     
    The purpose of this study was to investigate the difference between the effects of cementless and cemented total knee arthroplasty (TKA) through gait analysis. The subjects were 23 patients with osteoarthritis of the knees who were operated on with cementless TKA (average age 72.1 ± 5.0) and 25 patients with the same complaint who were operated on with cemented TKA (average age 70.7 ± 4.9). Physical therapy after surgery was the same except that in the case of cemented TKA, full weight bearing started 2 weeks earlier than for cementless TKA. Four force-plates were used to examine the knee function during customary gait. The differences before and 3 months after the operation were examined for the 2 groups and evaluated for velocity, averaged vertical component of floor reaction force (for both knees) with normalization for weight, and ratio of single support (single support time/gait cycle time) (for both knees). There was a significant difference in the ratio of single support on the non-operated side (p< 0.05). This was -3% in the case of cementless and 1% for cemented. The result was that the non-operated sides in the cementless cases were weaker than in the cemented cases. The 2 groups exhibited no significant differences on the operated side.
  • 田中 幸子, 高木 憲司, 田中 陽子, 浅野 圭司, 岡崎 満樹, 中野 博美, 吉田 隆幸, 村上 裕子, 吉村 理, 高柳 清美, 小林 隆司, 峯松 亮, 細田 昌孝, 佐々木 久登, 前島 洋, 松田 祐一, 松尾 彰久, 金村 尚彦  理学療法学  26-  (1)  1999/05/23  [Not refereed][Not invited]
  • 小林 隆司, 峯松 亮, 細田 昌孝, 佐々木 久登, 前島 洋, 松田 祐一, 田中 幸子, 松尾 彰久, 金村 尚彦, 吉村 理, 高柳 清美, 森 舞子  作業療法 = The Journal of Japanese Occupational Therapy Association  18-  1999/05/15  [Not refereed][Not invited]
  • 脊髄切断ラットにおけるマイスナー小体の変化
    259  -264  1999  [Not refereed][Not invited]
  • Ryuji Kobayashi, Masataka Hosoda, Akira Minematsu, Hisato Sasaki, Hiroshi Maejima, Sachiko Tanaka, Naohiko Kanemura, Akihisa Matsuo, Kunji Shirahama, Takehito Ueda, Chie Kamoda, Osamu Yoshimura  Journal of Physical Therapy Science  11-  (1)  31  -34  1999  [Not refereed][Not invited]
     
    Falls are a common problem among elderly persons, but the training for the fall prevention is not well established. Therefore, the effectiveness of toe grasp training was examined in this study. Spontaneous postural sway was tested on elderly persons (N=19) with eyes open and eyes closed. Using a force plate, sway responses were quantified in terms of the total track length, the environmental areas, the maximum amplitude distance of X-axis, and the maximum amplitude distance of Y-axis. The data was compared between the toe grasp training group and the control group. Total track length (eyes open and eyes closed), environmental areas (eyes open) and maximum amplitude distance of X-axis (eyes open and eyes closed) were improved significantly in the toe grasp training group. The activation of foot mechanoreceptors and improvements of the eye-leg coordination were thought to be factors in this improvement and toe grasp training is expected to be effective for fall prevention of the aged.
  • 高齢痴呆者の大腿骨頸部骨折
    194  -198  1999  [Not refereed][Not invited]
  • Analysis of postural stability caused by adaptation and footwear types
    WCPT 1999  454  1999  [Not refereed][Not invited]
  • 対麻痺の装具による歩行再建
    30  -31  1999  [Not refereed][Not invited]
  • 運動維持困難と半身妄想
    764  -768  1999  [Not refereed][Not invited]
  • Naohiko Kanemura, Ryuji Kobayashi, Masataka Hosoda, Akira Minematu, Hisato Sasaki, Hiroshi Maejima, Sachiko Tanaka, Akihisa Matuo, Kiyomi Takayanagi, Tetuo Maeda, Osamu Yoshmura  Journal of Physical Therapy Science  11-  (1)  25  -29  1999  [Not refereed][Not invited]
     
    The measurement of maximum voluntary isokinetic contraction is a common practice in research and clinical settings. The purpose of this study was to investigate the effect of visual feedback on muscle endurance. Subjects were 22 male, between the ages of 18 and 31. Each subject had no history of lower extremity joint injury, surgery, or disease. All subjects completed two isokinetic exercise test sessions. The tests consisted of 50 maximum voluntary isokinetic contractions, using dynamometer (KIN-COM500H) at 90 degrees per second. All left lower extremities were measured. On endurance and effects fatigue index of visual feedback and no visual feedback were compared about every tenth average peak torque. On comparisions between with and without visual feedback were analyzed using a paired t-test. On average between 11th and 20th repetitions, average peak torque with visual feedback was significantly greater than without visual feedback (p< 0.05). Excepting average torque between 11th and 20th repetition the results indicated no significant difference between with and without visual feedback. The fatigue index with feedback was not significantly different from that without visual feedback. These results suggest that visual feedback does not influence the fatigue index in measurements of muscle endurance.
  • 高齢者の足指把握訓練が静的重心動揺に及ぼす影響
    633  -636  1999  [Not refereed][Not invited]
  • 両上肢切断者の自動車運転
    321  -323  1999  [Not refereed][Not invited]
  • 痛みの感覚
    232  -238  1999  [Not refereed][Not invited]
  • 筋活動からみた各種動作に対する足関節装具の下腿筋群への影響―足関節捻挫予防の効果―
    775  -779  1999  [Not refereed][Not invited]
  • 痴呆高齢者の転倒状況と関連要因
    780  -786  1999  [Not refereed][Not invited]
  • Masataka Hosoda, Osamu Yoshimura, Kiyomi Takayanagi, Hiroshi Maejima, Ryuji Kobayashi, Akira Minematsu, Hisato Sasaki, Sachiko Tanaka, Naohiko Kanemura, Yoshihiro Itou, Isao Nara, Kazuho Hosoda  Journal of Physical Therapy Science  11-  (2)  79  -85  1999  [Not refereed][Not invited]
     
    The motions involved in the ordinary act of walking which we all perform unthinkingly are in fact very complex and require great agility, and once impairment occurs, abnormal gait will result. The present study experimented with mechanical analysis of walking with a false leg, with a view to clinical application. Attention was focused on wave components common to the floor reaction patterns of A/K (-trans-femoral (Above Knee) amputation) and B/K (-trans-tibial (Below Knee) amputation) subjects, and waveform factors were analyzed. In this research, a VICON 3D motion analysis system was used to analyze the walking motions of A/K and B/K subjects by means of stick figure and force plate representations. Attention was focused on knee-joint movement in stick-figure analysis, and on Z-component waveforms in force plate analysis. Results showed significant differences between false leg and natural leg during mid stance in A/K subjects. Furthermore, the false leg Z-component waveforms were saw-tooth type with A/K subjects, and notch type with B/K subjects.
  • Akira Minematsu, Osamu Yoshimura, Kiyomi Takayanagi, Ryuji Kobayashi, Masataka Hosoda, Hisato Sasaki, Hiroshi Maejima, Sachiko Tanaka, Akihisa Matsuo, Naohiko Kanemura  Journal of Physical Therapy Science  11-  (2)  105  -108  1999  [Not refereed][Not invited]
     
    This study investigated the effects of the ankle brace "CREATOR" on lower extremity muscles in performances by maximum amplitudes of the integrated electromyogram (IEMG). Twelve female handball players performed four exercises, repeated side step, vertical high jump, standing long jump and pivot. Maximum amplitudes of all muscles with the brace tended to be less than those without it. Those of tibialis anterior in the repeated side step and pivot, medial gastrocnemius in all performances except for repeated side step and peroneus longus and peroneus brevis in the repeated side step were significant. Thus with the brace, subjects performed the same with less muscle activity than without it, and this brace prevented an ankle sprain against the side direction.
  • Analysys of Postural Stability caused by Adaptation and Footwear types.
    PROCEEDINGS, 13th International Congress of the World Confederation for Physical Therapy  455  1999  [Not refereed][Not invited]
  • Ryuji Kobayashi, Masataka Hosoda, Akira Minematsu, Hisato Sasaki, Hiroshi Maejima, Sachiko Tanaka, Naohiko Kanemura, Akihisa Matsuo, Kunji Shirahama, Takehito Ueda, Chie Kamoda, Osamu Yoshimura  Journal of Physical Therapy Science  11-  (1)  31  -34  1999  [Not refereed][Not invited]
     
    Falls are a common problem among elderly persons, but the training for the fall prevention is not well established. Therefore, the effectiveness of toe grasp training was examined in this study. Spontaneous postural sway was tested on elderly persons (N=19) with eyes open and eyes closed. Using a force plate, sway responses were quantified in terms of the total track length, the environmental areas, the maximum amplitude distance of X-axis, and the maximum amplitude distance of Y-axis. The data was compared between the toe grasp training group and the control group. Total track length (eyes open and eyes closed), environmental areas (eyes open) and maximum amplitude distance of X-axis (eyes open and eyes closed) were improved significantly in the toe grasp training group. The activation of foot mechanoreceptors and improvements of the eye-leg coordination were thought to be factors in this improvement and toe grasp training is expected to be effective for fall prevention of the aged.
  • Analysis of postural stability caused by adaptation and footwear types
    WCPT 1999  454  1999  [Not refereed][Not invited]
  • Naohiko Kanemura, Ryuji Kobayashi, Masataka Hosoda, Akira Minematu, Hisato Sasaki, Hiroshi Maejima, Sachiko Tanaka, Akihisa Matuo, Kiyomi Takayanagi, Tetuo Maeda, Osamu Yoshmura  Journal of Physical Therapy Science  11-  (1)  25  -29  1999  [Not refereed][Not invited]
     
    The measurement of maximum voluntary isokinetic contraction is a common practice in research and clinical settings. The purpose of this study was to investigate the effect of visual feedback on muscle endurance. Subjects were 22 male, between the ages of 18 and 31. Each subject had no history of lower extremity joint injury, surgery, or disease. All subjects completed two isokinetic exercise test sessions. The tests consisted of 50 maximum voluntary isokinetic contractions, using dynamometer (KIN-COM500H) at 90 degrees per second. All left lower extremities were measured. On endurance and effects fatigue index of visual feedback and no visual feedback were compared about every tenth average peak torque. On comparisions between with and without visual feedback were analyzed using a paired t-test. On average between 11th and 20th repetitions, average peak torque with visual feedback was significantly greater than without visual feedback (p< 0.05). Excepting average torque between 11th and 20th repetition the results indicated no significant difference between with and without visual feedback. The fatigue index with feedback was not significantly different from that without visual feedback. These results suggest that visual feedback does not influence the fatigue index in measurements of muscle endurance.
  • Masataka Hosoda, Osamu Yoshimura, Kiyomi Takayanagi, Hiroshi Maejima, Ryuji Kobayashi, Akira Minematsu, Hisato Sasaki, Sachiko Tanaka, Naohiko Kanemura, Yoshihiro Itou, Isao Nara, Kazuho Hosoda  Journal of Physical Therapy Science  11-  (2)  79  -85  1999  [Not refereed][Not invited]
     
    The motions involved in the ordinary act of walking which we all perform unthinkingly are in fact very complex and require great agility, and once impairment occurs, abnormal gait will result. The present study experimented with mechanical analysis of walking with a false leg, with a view to clinical application. Attention was focused on wave components common to the floor reaction patterns of A/K (-trans-femoral (Above Knee) amputation) and B/K (-trans-tibial (Below Knee) amputation) subjects, and waveform factors were analyzed. In this research, a VICON 3D motion analysis system was used to analyze the walking motions of A/K and B/K subjects by means of stick figure and force plate representations. Attention was focused on knee-joint movement in stick-figure analysis, and on Z-component waveforms in force plate analysis. Results showed significant differences between false leg and natural leg during mid stance in A/K subjects. Furthermore, the false leg Z-component waveforms were saw-tooth type with A/K subjects, and notch type with B/K subjects.
  • Akira Minematsu, Osamu Yoshimura, Kiyomi Takayanagi, Ryuji Kobayashi, Masataka Hosoda, Hisato Sasaki, Hiroshi Maejima, Sachiko Tanaka, Akihisa Matsuo, Naohiko Kanemura  Journal of Physical Therapy Science  11-  (2)  105  -108  1999  [Not refereed][Not invited]
     
    This study investigated the effects of the ankle brace "CREATOR" on lower extremity muscles in performances by maximum amplitudes of the integrated electromyogram (IEMG). Twelve female handball players performed four exercises, repeated side step, vertical high jump, standing long jump and pivot. Maximum amplitudes of all muscles with the brace tended to be less than those without it. Those of tibialis anterior in the repeated side step and pivot, medial gastrocnemius in all performances except for repeated side step and peroneus longus and peroneus brevis in the repeated side step were significant. Thus with the brace, subjects performed the same with less muscle activity than without it, and this brace prevented an ankle sprain against the side direction.
  • Analysys of Postural Stability caused by Adaptation and Footwear types.
    PROCEEDINGS, 13th International Congress of the World Confederation for Physical Therapy  455  1999  [Not refereed][Not invited]
  • Osamu Yoshimura, Kiyomi Takayanagi, Ryuji Kobayashi, Masataka Hosoda, Akira Minematsu, Hisato Sasaki, Hiroshi Maejima, Yuiti Matsuda, Satiko Tanaka, Akihisa Matsuo, Naohiko Kanemura  Hiroshima Journal of Medical Sciences  47-  (2)  57  -62  1998/06  [Not refereed][Not invited]
     
    For patients with cervical spinal cord injuries to become independent in their ADL (Activities of Daily Living), residual arm function is very important. Also, age, sex, physical strength, obesity, spasticity, pain, contracture and motivation are related. We investigated the possibility of independence in ADL for patients with cervical spinal cord injuries, carrying out our evaluation based on the Zancolli Classification of Residual Arm Functions. Zancolli classification C6BII is taken as the boundary level for ADL independence. Rehabilitation is not only controlled by the patients with cervical spinal cord injuries themselves but also by the ability of the rehabilitation staff. This implies that taking responsibility in rehabilitation is important.
  • Osamu Yoshimura, Kiyomi Takayanagi, Ryuji Kobayashi, Masataka Hosoda, Akira Minematsu, Hisato Sasaki, Hiroshi Maejima, Yuiti Matsuda, Satiko Tanaka, Akihisa Matsuo, Naohiko Kanemura  Hiroshima Journal of Medical Sciences  47-  (2)  57  -62  1998/06  [Not refereed][Not invited]
     
    For patients with cervical spinal cord injuries to become independent in their ADL (Activities of Daily Living), residual arm function is very important. Also, age, sex, physical strength, obesity, spasticity, pain, contracture and motivation are related. We investigated the possibility of independence in ADL for patients with cervical spinal cord injuries, carrying out our evaluation based on the Zancolli Classification of Residual Arm Functions. Zancolli classification C6BII is taken as the boundary level for ADL independence. Rehabilitation is not only controlled by the patients with cervical spinal cord injuries themselves but also by the ability of the rehabilitation staff. This implies that taking responsibility in rehabilitation is important.
  • 救急救命センターでのリハビリテーションの役割―頚椎損傷の急性期管理
    198  -199  1998  [Not refereed][Not invited]
  • Basic research for hip protector
    ISPO 1998  780  1998  [Not refereed][Not invited]
  • The effect of the brace preventing a inversional ankle sprain to some kinds of actions on EMG in handball players
    ISPO 1998  814  1998  [Not refereed][Not invited]
  • The effect of sudden plantar flexion/inversion stress on EMG activity in the peronal, tibialis anterior, and gastrocnemius muscles in the normal ankle with a hard support brace
    ISPO 1998  816  1998  [Not refereed][Not invited]
  • Analysis of force plate and stick figure representation of A/K and B/K walking motions
    ISPO 1998  818  1998  [Not refereed][Not invited]
  • The effect of footwear style on postural readjustment in senior citizens
    ISPO 1998  822  1998  [Not refereed][Not invited]
  • The effect of plastic AFO on automatic postural responses of hemiplegia patients
    ISPO 1998  820  1998  [Not refereed][Not invited]
  • ナースのためのリハビリテーション講座
    459  -465  1998  [Not refereed][Not invited]
  • Masataka Hosoda, Osamu Yoshimura, Kiyomi Takayanagi, Ryuji Kobayashi, Akira Minematsu, Hisato Sasaki, Hiroshi Maejima, Yuiti Matsuda, Shiho Araki, Akikazu Nakayama, Toshiro Ishibashi, Takashi Terazono  Journal of Physical Therapy Science  10-  (1)  47  -51  1998  [Not refereed][Not invited]
     
    Influences on dynamic balance were examined by comparing footwear with clog thongs such as slippers with clog thongs, to footwear without them such as slippers without clog thongs, leather-soled sandals, and Japanese socks. Forty three university students in good health took part in this examination. In the case of footwear with clog thongs, postural response latencies to horizontal movement of the platform were decreased when compared with that for slippers without clog thongs. In the case of footwear with clog thongs, standing strength was decreased when the platform moved horizontally, compared with that for slippers without clog thongs. Among footwear with clog thongs, in the case of Japanese socks, both latency and strength were minimal compared to slippers with clog thongs and leather-soled sandals. Therefore, it can be said that footwear with thin soles, low heels and clog thongs the most stable and the best for preventing a fall.
  • The Effect of Plastic AFO on Automatic Postural Response of Hemiplegic Patients
    Conference Book, (]G0001[)(]G0010[)th World Congress of the International Society for Prosthetics and Orthotics  820  -822  1998  [Not refereed][Not invited]
  • Basic research for hip protector
    ISPO 1998  780  1998  [Not refereed][Not invited]
  • The effect of the brace preventing a inversional ankle sprain to some kinds of actions on EMG in handball players
    ISPO 1998  814  1998  [Not refereed][Not invited]
  • The effect of sudden plantar flexion/inversion stress on EMG activity in the peronal, tibialis anterior, and gastrocnemius muscles in the normal ankle with a hard support brace
    ISPO 1998  816  1998  [Not refereed][Not invited]
  • Analysis of force plate and stick figure representation of A/K and B/K walking motions
    ISPO 1998  818  1998  [Not refereed][Not invited]
  • The effect of footwear style on postural readjustment in senior citizens
    ISPO 1998  822  1998  [Not refereed][Not invited]
  • The effect of plastic AFO on automatic postural responses of hemiplegia patients
    ISPO 1998  820  1998  [Not refereed][Not invited]
  • Masataka Hosoda, Osamu Yoshimura, Kiyomi Takayanagi, Ryuji Kobayashi, Akira Minematsu, Hisato Sasaki, Hiroshi Maejima, Yuiti Matsuda, Shiho Araki, Akikazu Nakayama, Toshiro Ishibashi, Takashi Terazono  Journal of Physical Therapy Science  10-  (1)  47  -51  1998  [Not refereed][Not invited]
     
    Influences on dynamic balance were examined by comparing footwear with clog thongs such as slippers with clog thongs, to footwear without them such as slippers without clog thongs, leather-soled sandals, and Japanese socks. Forty three university students in good health took part in this examination. In the case of footwear with clog thongs, postural response latencies to horizontal movement of the platform were decreased when compared with that for slippers without clog thongs. In the case of footwear with clog thongs, standing strength was decreased when the platform moved horizontally, compared with that for slippers without clog thongs. Among footwear with clog thongs, in the case of Japanese socks, both latency and strength were minimal compared to slippers with clog thongs and leather-soled sandals. Therefore, it can be said that footwear with thin soles, low heels and clog thongs the most stable and the best for preventing a fall.
  • The Effect of Plastic AFO on Automatic Postural Response of Hemiplegic Patients
    Conference Book, (]G0001[)(]G0010[)th World Congress of the International Society for Prosthetics and Orthotics  820  -822  1998  [Not refereed][Not invited]

Industrial Property Rights

  • 特許3967644:足底圧分布－聴覚バイオフィードバックシステム    2004/07/07
    前島 洋

Research Grants & Projects

  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2023/04 -2027/03 
    Author : 前島 洋, 真先 敏弘, 榊間 春利, 齋藤 貴子, 高松 泰行
  • 日本学術振興会：科学研究費助成事業
    Date (from‐to) : 2020/04 -2024/03 
    Author : 榊間 春利, 丸山 征郎, 前島 洋, 菊池 清志, 大塚 章太郎
     
    本年度はプレコンディショニング運動（PE)と同等の効果が期待できる遠隔虚血プレコンディショニング（RIPC)の効果とそのメカニズムを調べた。我々のこれまでの研究で3週間のPEにより脳神経保護効果が期待できることを報告した。そこで、ラットに3週間のRIPCを実施し、脳梗塞を作製して梗塞巣の大きさを評価した。また、RIPC後に血液を採取して、血中BDNFをELISA法を用いて調べた。 老化促進マウスを用いて、予防的PEの開始時期の違いによる海馬における神経栄養因子の発現、神経炎症、運動機能改善効果を比較検討した。 運動療法と薬剤やサプリメントなどの併用効果について検討した。具体的には、人参養栄湯投与による脳梗塞後の機能回復や神経栄養因子の発現について調べた。 昨年度から継続していた予防的なプレコンディショニング運動中止後の脳神経保護効果が期待できる期間について行動学的、組織学的、免疫組織学的、分子生物学的に検討した研究結果については、本年度、国際誌論文としてまとめ、報告した。
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory)
    Date (from‐to) : 2021/07 -2024/03 
    Author : 前島 洋
     
    本研究の目的は、遺伝子発現の調整機構として可塑的遺伝子発現の促進が期待されるヒストン脱アセチル化酵素阻害剤（HDAC）の投与により可塑的脳内環境を提供し、中枢神経軸索再生に際して軸索伸長阻害因子を発現するオリゴデンドロサイトに代わり末梢神経由来シュワン細胞を損傷域に移植し、エピジェネテイクス制御下における軸索再生と機能回復効果を検証することであった。この目的のため初年度は、ヒストンアセチル化酵素阻害剤（HDAC）投与による脳内BDNF発現の影響について生体脳イメージングを用いて検証実験を進めるとともに、移植用細胞の培養法の確立、準備を進めた。HDAC投与による生体脳内におけるBDNFの発現を検証するため、BDNFのプロモーター域に蛍発光酵素Luciferase遺伝子を挿入したBDNF-Luc Tgマウスを繁殖、飼育し、このTgマウスを対象にHDAC阻害剤（NaB, 1200mg/kg）と脳深部の発光の検知を可能とする発光基質を腹腔内投与後、脳領域の発光を経時的に測定した。投与後１時間における生体脳イメージングにおいて、複数のマウスにおいてNaB投与時において生理的食塩水投与時と比較して脳領域のBDNF発現を示す発光強度の増加を示唆する予備的所見を得た。また、移植細胞の準備として、ラットシュワン細胞をCell lineより導入し、同細胞培養に適した培養条件を確立し、安定的に継代培養、凍結保存を進めた。併せて、BSL2、P2レベル実験の実験環境を整備し、次年度におけるレンチウィルスベクターを用いたマーカー蛋白であるGFP遺伝子導入への準備を進めた。
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
    Date (from‐to) : 2020/04 -2024/03 
    Author : 前島 洋, 尾崎 倫孝, 芳賀 早苗, 高松 泰行, 榊間 春利, 真先 敏弘
     
    昨年度までに得られた所見として、トレッドミル運動、或いはα5サブユニットを含むGABA受容体の特異的阻害薬L-655,708投与の単独介入による脳出血後の運動機能回復は限定的であるが、両者を組み合わせた介入により相乗的な回復効果が確認されていた。本年度は、これらの個体から採取した脳・脊髄サンプルの解析を進め、併用介入群に生じた可塑性修飾について検証を行った。L-655,708投与により大脳皮質運動野BDNF発現の増強が認められた。加えて、併用介入群の脊髄においては、 シナプスや軸索の可塑性に関与する分子マーカーの発現増強が認められた。このことから、併用介入群の効果的な機能回復には、脳内だけでなく脊髄における可塑性修飾も重要であることが示唆された。 脳におけるBDNF発現の生体イメージング計測を目的に、BDNFのプロモーター域に蛍発光酵素Luciferase遺伝子を挿入したBDNF-Luc Tgマウスを繁殖、飼育した。このTgマウスを対象に脳深部の発光の検知を可能とする発光基質AkaLumine-HCl (TokeOni)を腹腔内投与後、脳領域の発光を運動介入後に経時的に定量する一連の手法を開発した。この生体脳イメージングの手法を用いて、トレッドミル運動がBDNF発現に与える効果について検証を行った。単回のトレッドミル運動後４-8時間内において脳領域における発光、即ちBDNF発現が増強され、更に２週間のトレッドミル運動の継続することで運動後のより早いタイミングにBDNF発現増強が生じることを確認した。 一方、この生体脳イメージングを脳出血モデルに対して応用する際に、これまでのステレオタキシックシステムを用いた微量コラゲナーゼ注入によるモデル作成において、計測脳領域の皮膚処理が発光に影響を与える問題が生じ、術時における頭部の皮膚切開、縫合部位について検討を要することが示唆された。
  • 日本学術振興会：科学研究費助成事業
    Date (from‐to) : 2019/04 -2023/03 
    Author : 森山 英樹, 小澤 淳也, 新倉 隆宏, 前島 洋, 古和 久朋, 秋末 敏宏
     
    本研究では、老化の防止を目指すための運動の理論的基盤の構築と、その応用による運動模倣薬の開発を目的とする。運動の理論的基盤の構築ために、運動の分子機序を明らかにした。一昨年度に同定した運動の種類（有酸素運動・レジスタンス運動）別の骨格筋・骨・関節軟骨・脳にとって最も効果的、つまり適度な強度の運動を、マウスに行わせた後、運動の最たる効果器である骨格筋を対象に、遺伝子発現をRNA-seqで、エピジェネティクスをRRBS、タンパク質発現をIBTリン酸化プロテオームで網羅的に解析した。その結果、有酸素運動とレジスタンス運動で共通して、特にIRS-PI3K-Aktシグナルの変化が顕著であり、適度な運動は，インスリンシグナル伝達を刺激しグルコース代謝を促進するとともに，AMPKシグナルを活性化しエネルギー代謝を維持・促進することが明らかになった。さらにPPI解析によりハブ遺伝子を調べ、ユビキチン・プロテアソーム系、概日リズム、熱ショックタンパクが中心として働くことが分かった。これらの結果をもとに、運動模倣薬のターゲットとなる候補物質を探索し、最終的に新規化合物とドラッグリポジショニングで計6つまで絞り込んだ。これらの投与量を変えマウスに2週間投与したところ、うち3つの候補物質で、脂肪量減少と運動耐容能向上といった有酸素運動の効果や、筋力増強と筋肥大といったレジスタンス運動の効果がみられた。なお、この効果は、実際の運動による効果よりも優れており、有害事象もみられなかった。
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2019/06 -2022/03 
    Author : MORIYAMA Hideki
     
    The goal of this study was to identify genetic and environmental factors underlying "good motor skills". Our results from selective breeding for motor coordination demonstrate the heritability of "motor skills". Comprehensive genomic and gene functional analyses identified candidate genes responsible for "good motor skills" in the cerebellum and cerebral cortex. Additionally, environmental enrichment induced better motor coordination and increased responsive gene expression, indicating that environmental factors contribute to "good motor skills".
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2018/04 -2022/03 
    Author : Saito Hiroshi
     
    To develop training methods to efficiently achieve improvement in balance ability in the elderly, we investigated balance ability on a rapid motor control task, an adjusting ankle movement task, and a toe task during standing. As a result, we found that the indispensable factors for improvement in balance ability are the ability to adjust muscle activities of tibialis anterior and gastrocnemius, the ability to switch between co-contraction and reciprocal contraction, and the functions of the toes to maintain a standing posture. Furthermore, we revealed these abilities are susceptible to aging.
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2018/04 -2021/03 
    Author : Masaki Toshihiro
     
    Extra-nerve tissue repair function of Schwann cells was analyzed. As a result, it was delineated that mouse primary Schwann cells secrete PDGF-AA and IGFBP3. Also expression of Pdgfa and Igfbp3 were confirmed by RT-PCR. PDGF-AA is reported to induce blastema prolifration which is critically important in tissue regeneration in both amphibians and mammals. In Schwann cell transplantation to mouse skin injury model, it was suggested that transplanted Schwann cells enhance skin regeneration by recruiting endogenous Schwann cells. However, direct evidence showing Schwann cells enhance skin regeneration could not be obtained.
  • エピジェネティクス制御に基づく新たな脳卒中運動療法の探索
    日本学術振興会：科学研究費補助金 挑戦的萌芽研究
    Date (from‐to) : 2018/04 -2021/03 
    Author : 前島 洋
  • 脳卒中リハビリテーションにおける薬理的シナプス伝達制御を伴う新たな運動療法の開発
    日本学術振興会：科学研究費補助金 基盤研究（Ｂ）
    Date (from‐to) : 2017/04 -2021/03 
    Author : 前島 洋
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2015/04 -2018/03 
    Author : Saito Hiroshi, CHIBA TAKESHI, SABASHI KENTO
     
    To examine how postural control adapts and aging affects which aspect of postural control, we investigated learning effects and aging effects on a repetitive reaching task, ball catching task and somatosensory system stimulating task in younger and elderly. The results of this study showed that changes in posture control may affect motor learning, the ankle joint motion and muscle activities of gastrocnemius are influenced by aging and somatosensory system strongly influences improvement in balance ability.
  • 運動療法による中枢神経系退行抑制におけるエピジェネティック制御の解明
    日本学術振興会：科学研究費補助金 挑戦的萌芽研究
    Date (from‐to) : 2015/04 -2018/03 
    Author : 前島 洋
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2012/04 -2015/03 
    Author : KANEMURA Naohiko, TAKAYANAGI Kiyomi, IMAGITA Hidetaka, MORIYAMA Hideki, MAEJIMA Hiroshi
     
    Moderate exercise, the release of neurotrophic factors is increased , neural activity is activated. In this study, whether it is possible to activate the nervous system that has been decreased by aging and to verify the effect of the running and balance exercise. Activation of the motor neurons stained of the lumbar spinal cord was less change in some exercise. Their expression of neurotrophins, neurogenesis and neurpeptide were enhanced and the activity of apotosis wad down-regulated by locomotor exercise in the spinal cord of the difference of age. Improvements due to the motion, not the nerve itself, it is necessary to consider in the pleiotropic functions for related factors activated neural activity.
  • 中枢神経系抑制性シナプス伝達の制御による運動学習増強に関する実験動物学的研究
    日本学術振興会：科学研究費補助金 基盤研究（Ｃ）
    Date (from‐to) : 2012/04 -2015/03 
    Author : 前島洋
  • 高齢者のバランス運動学習における脳内シナプス修飾に関する実験動物学的研究
    日本学術振興会：科学研究費補助金 基盤研究（Ｃ）
    Date (from‐to) : 2010/03 -2012/04 
    Author : 前島洋
  • 安心安全リハビリテーション平行棒の開発と臨床応用
    科学技術振興機構(JST)：シーズ発掘試験
    Date (from‐to) : 2008/04 -2009/03 
    Author : 前島洋
  • 高齢者の運動習慣による脳内シナプス増強に関する実験動物学的研究
    日本学術振興会：科学研究費補助金 基盤研究（Ｃ）
    Date (from‐to) : 2007/04 -2009/03 
    Author : 前島洋
  • 平成19年度健康運動講座の事業評価及び事業効果の検証
    広島県山県郡安芸太田町：国保ヘルスアップモデル事業補助金
    Date (from‐to) : 2007/04 -2008/03 
    Author : 前島洋
  • ウォーキングが高齢者の神経筋接合部シナプス可塑性に与える効果−高齢ラットモデルを用いた検証―
    財団法人慢性疾患・リハビリテーション研究振興財団：財団法人慢性疾患・リハビリテーション研究振興財団研究助成金
    Date (from‐to) : 2006/04 -2008/03 
    Author : 前島洋
  • 健康運動講座の事業評価及び事業効果の検証
    広島県山県郡安芸太田町：国保ヘルスアップモデル事業補助金
    Date (from‐to) : 2006/04 -2007/03 
    Author : 前島洋
  • 電位依存性ナトリウムチャンネルの構造活性相関に関する研究
    文部科学省：文部科学省海外先進教育研究実践プログラム補助金
    Date (from‐to) : 2005/03 -2006/03 
    Author : 前島洋
  • 高齢者群における継続的運動療法導入後の筋力・体力測定（導入前, 修了時）並びに当該運動効果
    広島県山県郡安芸太田町：国保ヘルスアップモデル事業補助金
    Date (from‐to) : 2004/04 -2005/03 
    Author : 前島洋
  • 低反応レベルレーザー療法におけるナトリウムチャンネルブロックの原理
    日本学術振興会：科学研究費補助金 若手研究（B）
    Date (from‐to) : 2004/04 -2005/03 
    Author : 前島洋
  • 足底圧分布―聴覚バイオフィードバックシステムの開発と臨床応用に関する研究
    日本学術振興会：科学研究費補助金 若手研究（B）
    Date (from‐to) : 2001/04 -2002/03 
    Author : 前島洋
  • falling of community-dwelling elderly persons
  • Postural control of human
  • Molecular mechanism of voltage dependent sodium channel

Educational Activities

Teaching Experience

  • Introduction to Physical TherapyIntroduction to Physical Therapy Hokkaido University
  • Handicap and RehabilitationHandicap and Rehabilitation Hokkaido University
  • Seminar on Motor Control
    開講年度 : 2021
    課程区分 : 修士課程
    開講学部 : 保健科学院
    キーワード : 運動制御理論、姿勢制御、運動学習、機能回復、バランス評価 数値計算および可視化のプログラミング 英文抄読
  • Motor Control
    開講年度 : 2021
    課程区分 : 修士課程
    開講学部 : 保健科学院
    キーワード : 床反力，体重心，関節可動域，筋電図 数値計算および可視化のプログラミング 実験動物, 遺伝子, リアルタイムPCR法
  • Experimental Methodology
    開講年度 : 2021
    課程区分 : 修士課程
    開講学部 : 保健科学院
    キーワード : 実験計画法，生物化学的研究方法，生理学的研究方法，分子・細胞生物学的研究方法，分析化学的研究方法，医用工学的研究方法，臨床医科学的研究方法，測定データ解析方法
  • Advanced Study of Rehabilitation Science
    開講年度 : 2021
    課程区分 : 博士後期課程
    開講学部 : 保健科学院
    キーワード : 理学療法、作業療法、精神障害、運動器障害、中枢神経障害
  • Advanced Seminar on Rehabilitation Science
    開講年度 : 2021
    課程区分 : 博士後期課程
    開講学部 : 保健科学院
    キーワード : 理学療法、作業療法、精神障害、運動器障害、中枢神経障害
  • Neurotherapeutics
    開講年度 : 2021
    課程区分 : 学士課程
    開講学部 : 医学部
    キーワード : 脳血管障害、失調症、パーキンソン病，多発性硬化症，筋委縮性側策硬化症、感覚障害，疼痛
  • Clinical Training Ⅲ
    開講年度 : 2021
    課程区分 : 学士課程
    開講学部 : 医学部
    キーワード : 問題点抽出、治療計画、理学療法
  • Clinical Training Ⅳ
    開講年度 : 2021
    課程区分 : 学士課程
    開講学部 : 医学部
    キーワード : 問題点抽出、治療計画、理学療法
  • Freshman Seminar
    開講年度 : 2021
    課程区分 : 学士課程
    開講学部 : 全学教育
    キーワード : リハビリテーション、障害、高齢者、脆弱、運動療法、スポーツ傷害、脳卒中、姿勢バランス、神経疾患、脳卒中、運動器障害、認知機能
  • Clinical Training Ⅰ
    開講年度 : 2021
    課程区分 : 学士課程
    開講学部 : 医学部
    キーワード : 理学療法、臨床、測定、評価
  • Therapeutic Treatment
    開講年度 : 2021
    課程区分 : 学士課程
    開講学部 : 医学部
    キーワード : 運動療法、リハビリテーション
  • Physical Modalities
    開講年度 : 2021
    課程区分 : 学士課程
    開講学部 : 医学部
    キーワード : 物理療法，温熱療法、寒冷療法、水治療法、極低温療法、極超短波療法、超音波療法、牽引療法、電気刺激療法、光線療法、非侵襲的脳刺激法、筋トーヌス、疼痛、関節拘縮
  • Rehabilitation Medicine
    開講年度 : 2021
    課程区分 : 学士課程
    開講学部 : 医学部
    キーワード : 障害、脳血管障害、脊髄損傷、神経筋疾患、発達障害、内部障害、廃用症候群、学習理論、チームワーク
  • Treatment of Developmental Disorders
    開講年度 : 2021
    課程区分 : 学士課程
    開講学部 : 医学部
    キーワード : 原始反射、姿勢反応、姿勢緊張、正常発達、脳性麻痺、筋ジストロフィー症、ダウン症、理学療法
  • Physiology for Rehabilitation
    開講年度 : 2021
    課程区分 : 学士課程
    開講学部 : 医学部
    キーワード : 興奮伝導、神経、反射、姿勢反応，高次脳機能，感覚、関節運動，筋収縮のメカニズム，運動制御，運動学習, 運動生理
  • Clinical Training Ⅱ
    開講年度 : 2021
    課程区分 : 学士課程
    開講学部 : 医学部
    キーワード : 評価実習、整形外科疾患、神経系疾患
  • Physiology for Rehabilitation (Laboratory Study)
    開講年度 : 2021
    課程区分 : 学士課程
    開講学部 : 医学部
    キーワード : 血圧、心電図、筋電図、超音波画像、感覚
  • Seminar in Research Methods of Physical Therapy Ⅰ
    開講年度 : 2021
    課程区分 : 学士課程
    開講学部 : 医学部
    キーワード : 理学療法研究、医学統計
  • Seminar in Research Methods of Physical Therapy Ⅱ
    開講年度 : 2021
    課程区分 : 学士課程
    開講学部 : 医学部
    キーワード : 卒業研究、統計、論文作成

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