Researcher Database

Hokkaido University Hospital Cancer Center
Assistant Professor

Researcher Profile and Settings


  • Hokkaido University Hospital Cancer Center

Job Title

  • Assistant Professor

J-Global ID

Research Activities

Published Papers

  • Mototsugu Miura, Kenkichi Tsuruga, Yuji Morimoto
    Journal of medical case reports 13 (1) 353 - 353 2019/11/30 [Refereed][Not invited]
    BACKGROUND: Chemical coping is an inappropriate method for dealing with stress through the use of opioids; it is considered the stage prior to abuse and dependence. In patients with cancer, it is important to evaluate the risk of chemical coping when using opioids. There are some pediatric opioid use-related tolerances and addictions; however, no mention of chemical coping has been found. CASE PRESENTATION: We present a case of an 11-year-old Japanese boy with acute lymphocytic leukemia. After transplantation, he complained of abdominal and articular pain, which are considered as symptoms of graft-versus-host disease; thus, opioid therapy was initiated, and the dose was gradually increased for pain management, resulting in a high dose of 2700 μg/day of fentanyl (4200-4700 μg/day including the rescue dose). After switching from fentanyl to oxycodone injections, he continued to experience pain, and there was no change in the frequency of oxycodone rescue doses. Physically, his pain was considered to have alleviated; thus, there was the possibility of mental anxiety resulting in the lowering of pain threshold and the possibility of chemical coping. Mental anxiety and stress with progress through schooling was believed to have resulted in chemical coping; thus, efforts were made to reduce the boy's anxiety, and opioid education was provided. However, dose reduction was challenging. Ultimately, with guidance from medical care providers, the opioid dose was reduced, and the patient was successfully weaned off opioids. CONCLUSIONS: When chemical coping is suspected in pediatric patients, after differentiating from pseudo-addiction, it might be necessary to restrict the prescription for appropriate use and to provide opioid education while taking into consideration the emotional background of the patient that led to chemical coping.

Conference Activities & Talks

  • 心因性疼痛患者が癌になった際のオピオイド調整の一例
    三浦基嗣, 敦賀健吉, 前田洋典, 長祐子, 石岡明子, 佐藤雪絵, 熊井正貴, 加藤信太郎, 小柳 遼
    第2回 日本緩和医療学会 北海道支部学術大会  2019
  • 当院での先行オピオイド併用メサドン導入方法と使用経験
    三浦基嗣, 敦賀健吉, 藤井知昭, 長谷徹太郎, 森本裕二
    第52回 日本ペインクリニック学会  2019
  • オピオイド減量に難渋したケミカルコーピングの可能性のある小児がん患者の一例
    三浦基嗣, 敦賀健吉, 長谷徹太郎, 熊井正貴, 加藤信太郎, 小柳遼, 林絵里
    第1回 日本緩和医療学会 北海道支部学術大会  2018
  • QOLを維持しつつ高用量オピオイド投与を行えた小児がん患者の一例
    三浦基嗣, 長谷徹太郎, 竹田素子, 熊井正貴, 敦賀健吉
    第22 回 日本緩和医療学会  2018
  • スガマデクス使用開始に伴う術中筋弛緩量の変化
    三浦基嗣, 加藤類, 森本裕二
    第2回日本麻酔科学会, 北海道・東北支部大会  2012
  • 前立腺全摘術後尿失禁に対し人工括約筋埋め込み術の経験
    三浦基嗣, 田中博, 三井貴彦, 橘田岳也, 野々村克也
    第382回日本泌尿器科学会北海道地方会  2011
  • 重症男性尿失禁に対する人工尿道括約筋による治療成績  [Not invited]
    三浦基嗣, 田中博, 三井貴彦, 橘田岳也, 野々村克也
    第76回日本泌尿器科学会東部総会  2011


  • FUJII Tomoaki, MIURA Mototsugu, HASE Tetsutaro, TSURUGA Kenkichi, MORIMOTO Yuji  Journal of Japan Society of Pain Clinicians  26-  (1)  36  -39  2019  [Not refereed][Not invited]

    Complex regional pain syndrome (CRPS) accompanies allodynia. Allodynia impairs the quality of life in chronic pain patients and is often difficult to treat. It has been suggested that yokukansan has an anti-allodynic effect. In this case report, shichimotsukokato was administered to a patient with CRPS who could not continue to take yokukansan. Shichimotsukokato provided the same anti-allodynic effect as yokukansan. Shichimotsukokato contains chotoko, which is the active constituent leading to anti-allodynia action in yokukansan. This case suggests that shichimotsukokato may offer similar anti-allodynia effect as yokukansan.

  • FUJII Tomoaki, MIURA Mototsugu, HASE Tetsutaro, TSURUGA Kenkichi, MORIMOTO Yuji  Journal of Japan Society of Pain Clinicians  24-  (4)  349  -352  2017  [Not refereed][Not invited]

    Many patients with autosomal dominant polycystic kidney disease (ADPKD) have some sort of pain, and a stepwise approach has been proposed as a management method for it. We managed the pain of an ADPKD patient who had combined multiple hepatic cysts. Since tramadol was effective for the pain, which was also relieved by an epidural block using a low concentration of a local anesthetic, we diagnosed that the pain was mainly derived from internal organs. We prescribed opioids and the pain was relieved. We need to pay attention to the possibility of an increase in renal cysts due to enhanced vasopressin action by opioids, but opioids may be effective for the visceral pain of ADPKD.

  • 三浦 基嗣, 敦賀 健吉, 瀧川 千鶴子  緩和ケア  26-  (6)  409  -414  2016/11  [Not refereed][Not invited]

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