Kaga Sanae(Faculty of Health Sciences　Health Sciences　Medical Laboratory Science)

Mar. 2015, Japanese Society of Echocardiography, Japanese Society of Echocardiography Distinguished Abstract Award for Overseas Congress
Practical Role of Continuous-Wave Doppler Measurements of Diastolic Velocities of Pulmonary Regurgitation for the Assessment of Pulmonary Hypertension.
Sanae Kaga

May 2010, Japanese Society of Echocardiography, 2009 Best Manuscript Award, J Echocardiogr.
Right ventricular diastolic dysfunction in patients with left ventricular hypertrophy: analysis of right ventricular myocardial relaxation using two-dimensional speckle tracking imaging
Sanae Kaga

Apr. 2008, 日本心エコー図学会, 第19回日本心エコー図学会学術集会Sonographer's Session最優秀賞
左室肥大における右室機能障害の機序: 2Dスぺックルトラッキング法による検討.
加賀早苗

■ Papers

Echocardiographic Estimation of right ventricular stroke work index based on pulmonary regurgitant velocity in heart failure with reduced ejection fraction.
Yuta Tateishi; Michito Murayama; Sanae Kaga; Kie Yamazaki; Fuka Ando; Mana Goto; Yusuke Yanagi; Shinobu Yokoyama; Hisao Nishino; Makoto Kambayashi; Yui Shimono; Kosuke Nakamura; Yoji Tamaki; Suguru Ishizaka; Hiroyuki Iwano; Toshiyuki Nagai; Toshihisa Anzai
Journal of echocardiography, 04 Dec. 2025, [Domestic magazines]
English, Scientific journal, BACKGROUND: Right ventricular (RV) dysfunction is a key determinant of mortality in heart failure with reduced left ventricular ejection fraction (HFrEF). RV stroke work index (RVSWI) is an established invasive parameter of RV function; however, echocardiographic methods for estimating RVSWI have not yet been fully established. We hypothesized that the pulmonary regurgitant (PR) velocity waveform-derived early-diastolic pulmonary artery-RV pressure gradient (PRPG) would allow an accurate estimation of RVSWI because of its fidelity to the original formula. This study aimed to investigate whether non-invasive estimation of RVSWI is feasible in patients with HFrEF. METHODS: In this retrospective study, 120 adult patients with HFrEF who underwent right heart catheterization within 24 h of echocardiography were included. RVSWI was calculated as (mean pulmonary artery pressure - mean right atrial pressure) × stroke volume index (SVI). Based on the continuous-wave Doppler velocity measurements of PR, echocardiographic estimation of RVSWI was calculated as PRPG × pulsed-wave Doppler-derived SVI (RVSWIPR). RESULTS: The RVSWIPR was significantly correlated with RVSWI (ρ = 0.670, p < 0.001). Bland-Altman analysis showed no direct fixed bias. Sensitivity analysis performed in 21 patients with HFrEF and severe tricuspid regurgitation, which is a challenging subgroup for non-invasive RV function assessment, showed similar results. In the receiver operating characteristic curve analyses to detect the patients with RVSWI < 250 mmHg∙mL/m2, the area under the curve was 0.954, and a cut-off value of 371 mmHg∙mL/m2 showed 100% sensitivity and 82% specificity. CONCLUSIONS: RVSWIPR, based on PR velocity waveform analysis, was useful for the non-invasive assessment of RVSWI in HFrEF.

Acute effects of dynamic stretching on the mechanical properties of the triceps surae muscles assessed using shear wave ultrasound elastography.
Kensuke Oba; Michito Murayama; Sanae Kaga; Mina Samukawa
Journal of medical ultrasonics (2001), 09 Oct. 2025, [Domestic magazines]
English, Scientific journal, PURPOSE: Dynamic stretching (DS), characterized by repeated movements through the joint range of motion via antagonist muscle contraction, is thought to reduce muscle stiffness through mechanisms such as reciprocal inhibition. However, whether DS effectively decreases muscle stiffness remains unclear. This study aimed to investigate the acute effects of DS on triceps surae muscle stiffness using shear wave elastography. METHODS: Sixteen healthy young adults performed both 120-s DS and control (no stretching) tasks. Shear wave velocities of the medial gastrocnemius (MG), lateral gastrocnemius (LG), and soleus (SOL) muscles were measured as indicators of muscle stiffness before and after DS. RESULTS: Our findings indicated that DS significantly reduced the shear wave velocity in the MG. However, no significant changes were observed in the shear wave velocities of the LG and SOL. CONCLUSION: DS effectively decreased MG stiffness, with no observed effects in the LG or SOL. These findings highlight inter-muscular variability in response to DS and suggest that DS may be particularly beneficial for targeting stiffness in the MG of the triceps surae muscles.

Left Ventricular Stroke Work Index as a Predictor of Aortic Stenosis After Transcatheter Aortic Valve Implantation.
Hiroyuki Iwano; Kimi Sato; Noor Albakaa; Shingo Tsujinaga; Suguru Ishizaka; Yasuyuki Chiba; Hisao Nishino; Sanae Kaga; Tomoko Ishizu; Yoshihiro Seo
Echocardiography (Mount Kisco, N.Y.), 42, 9, e70281, Sep. 2025, [International Magazine]
English, Scientific journal, PURPOSE: Evaluation of left ventricular (LV) myocardial contractility to predict outcome in aortic stenosis (AS) is challenging because global longitudinal strain (GLS) does not take afterload into account. We thus tested prognostic value of an echocardiographic index of LV external work, stroke work index (SWI) in AS patients undergoing transcatheter aortic valve implantation (TAVI). METHODS: We evaluated 1583 patients who underwent TAVI from database of a multicenter retrospective study. As an index of LV external work, echocardiographic LV SWI was calculated as 0.0136 × [stroke volume index × (mean aortic pressure + mean transvalvular pressure gradient-LV end-diastolic pressure)] [g × min/m2], where LV end-diastolic pressure was estimated as 4.9 + (0.62 × E/e') [mmHg]. GLS data was available in 902 patients. Primary endpoint was defined as cardiac death or worsening heart failure. RESULTS: During a median follow-up period of 725 days, 262 patients experienced primary endpoint. Kaplan-Meyer analysis showed that patients having lower LV SWI had lower event-free survival. Furthermore, Cox regression analysis showed that LV SWI was associated with primary endpoint independently of other clinically relevant factors. When influence of LV SWI on outcome was tested in preserved and reduced GLS groups respectively, LV SWI discriminated event-free survival in patients showing reduced GLS. CONCLUSION: Reduced LV SWI before TAVI was associated with poorer outcomes in AS patients. Furthermore, combined assessment of LV SWI and GLS is expected to improve prognostic risk stratification in AS patients undergoing TAVI.

Role of Passive Leg Raise Stress Echocardiography in Latent Stiff Left Atrial Syndrome.
Michito Murayama; Hiroyuki Iwano; Satonori Tsuneta; Noriyuki Otsuka; Makoto Kambayashi; Yui Shimono; Yoji Tamaki; Suguru Ishizaka; Shinobu Yokoyama; Hisao Nishino; Sanae Kaga; Toshiyuki Nagai; Toshihisa Anzai
Circulation. Cardiovascular imaging, e018662, 06 Aug. 2025, [International Magazine]
English, Scientific journal

Investigation of Varying Durations of Dynamic Stretches on Muscle Stiffness of the Ankle Plantar Flexors Using Shear Wave Ultrasound Elastography.
Kensuke Oba; Michito Murayama; Sanae Kaga; Mina Samukawa
Journal of musculoskeletal & neuronal interactions, 25, 1, 68, 73, 01 Mar. 2025, [International Magazine]
English, Scientific journal, OBJECTIVES: This study investigated the acute effects of dynamic stretch (DS) duration on the muscle stiffness of the ankle plantar flexor using shear wave ultrasound elastography. METHODS: Eighteen healthy young participants were enrolled in this study. DS with one set (DS1) or four sets (DS4) of 30 s each was performed randomly. Shear wave velocity in the medial gastrocnemius (MG) was measured before and after DS to assess muscle stiffness of the MG. RESULTS: Two-way repeated-measures analysis of variance (condition × time) showed a significant interaction with the shear wave velocity (p = 0.02). Shear wave velocity significantly decreased after the DS4 than before (before:3.09 ± 0.59 m/s; after: 2.86 ± 0.43 m/s). However, no significant differences were observed in shear wave velocity between before and after DS1 (before: 2.96 ± 0.56 m/s; after: 3.19 ± 0.56 m/s). There were no significant differences in shear wave velocity at baseline condition. After the intervention, significantly lower shear wave velocity was observed in DS4 than in DS1. CONCLUSIONS: The results of this study demonstrate that DS with four sets of 30 s effectively decreased the muscle stiffness of the MG.

Optimal Cut Plane for Tricuspid Annular Plane Systolic Excursion Measurement.
Michito Murayama; Sanae Kaga; Hisao Nishino; Yusuke Yanagi; Mana Goto; Fuka Ando; Shinobu Yokoyama; Marina Yamaguchi; Kazunori Okada; Masahiro Nakabachi; Makoto Kambayashi; Yui Shimono; Kosuke Nakamura; Yoji Tamaki; Suguru Ishizaka; Hiroyuki Iwano; Toshiyuki Nagai; Toshihisa Anzai
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 14 Jan. 2025, [International Magazine]
English, Scientific journal

Role of anatomical regurgitant orifice area of the tricuspid valve measurements in patients with beyond severe tricuspid regurgitation.
Michito Murayama; Suguru Ishizaka; Keita Sakaguchi; Rion Ando; Hisao Nishino; Sanae Kaga; Toshihisa Anzai
Journal of echocardiography, 24 Dec. 2024, [Domestic magazines]
English, Scientific journal

Validation of Left Ventricular Filling Pressure Evaluation by Order of Tricuspid and Mitral Valve Opening in Patients With Atrial Fibrillation.
Hisao Nishino; Michito Murayama; Hiroyuki Iwano; Nobuyuki Kagiyama; Yutaka Nakamura; Yuka Akama; Misako Toki; Sachiko Takamatsu; Taiji Okada; Yasuyuki Chiba; Masahiro Nakabachi; Shinobu Yokoyama; Mana Goto; Yukino Suzuki; Suguru Ishizaka; Ko Motoi; Yoji Tamaki; Hiroyuki Aoyagi; Kosuke Nakamura; Sanae Kaga; Chiaki Watanabe; Kiwamu Kamiya; Toshiyuki Nagai; Takanori Teshima; Toshihisa Anzai
Circulation. Cardiovascular imaging, 17, 11, e017134, Nov. 2024, [International Magazine]
English, Scientific journal, BACKGROUND: Accurate assessment of left ventricular filling pressure in patients with atrial fibrillation or flutter (AF) remains difficult. A novel 2-dimensional scoring system, visually assessing time difference between mitral valve and tricuspid valve opening (VMT) score, based on temporal analysis of early diastolic valve opening, could be applied to these patients. We aimed to determine the usefulness of the VMT score in patients with AF. METHODS: We analyzed 119 consecutive patients with AF who underwent cardiac catheterization as a derivation cohort. The diagnostic performance of the VMT score was further evaluated in an external data set containing 189 patients with AF. Elevated left ventricular filling pressure was defined as a mean pulmonary arterial wedge pressure ≥15 mm Hg. The time sequence of atrioventricular valve opening was visually assessed and scored (0, tricuspid valve first; 1, simultaneous; 2, mitral valve first). When the inferior vena cava was dilated, 1 point was added, and the VMT score was finally graded as 0 to 3. Conventional Doppler parameters to estimate left ventricular filling pressure were also measured. RESULTS: Pulmonary arterial wedge pressure was elevated with an increase in the VMT score (0: 10±3, 1: 13±5, 2: 22±7, 3: 27±6 mm Hg; P<0.001), resulting in a significant rise in pulmonary arterial wedge pressure from VMT score 1 to 2. VMT≥2 predicted elevated pulmonary arterial wedge pressure with an accuracy of 87%, and the diagnostic accuracy of the VMT score was significantly higher than that of conventional Doppler parameters (C index, 0.88 versus 0.54-0.68; P<0.001). In addition, VMT ≥2 showed an incremental predictive value over plasma brain natriuretic peptide levels (C index, 0.79-0.93; P<0.001). In the external validation cohort, VMT≥2 demonstrated acceptable accuracy of 72%. CONCLUSIONS: VMT scoring was a useful echocardiographic marker of elevated left ventricular filling pressure and had an incremental benefit over practical biomarkers in patients with AF.

Head-to-Head Comparison of Hepatic Vein and Superior Vena Cava Flow Velocity Waveform Analyses for Predicting Elevated Right Atrial Pressure.
Michito Murayama; Sanae Kaga; Airi Onoda; Hisao Nishino; Shinobu Yokoyama; Mana Goto; Yukino Suzuki; Yusuke Yanagi; Yui Shimono; Kosuke Nakamura; Hiroyuki Aoyagi; Yoji Tamaki; Suguru Ishizaka; Hiroyuki Iwano; Kiwamu Kamiya; Toshiyuki Nagai; Toshihisa Anzai
Ultrasound in medicine & biology, 03 Jun. 2024, [International Magazine]
English, Scientific journal, OBJECTIVE: Blood flow in the hepatic veins and superior vena cava (SVC) reflects right heart filling; however, their Doppler profiles are often not identical, and no studies have compared their diagnostic efficacies. We aimed to determine which venous Doppler profile is reliable for detecting elevated right atrial pressure (RAP). METHODS: In 193 patients with cardiovascular diseases who underwent cardiac catheterization within 2 d of echocardiography, the hepatic vein systolic filling fraction (HV-SFF) and the ratio of the peak systolic to diastolic forward velocities of the SVC (SVC-S/D) were measured. HV-SFF < 55% and SVC-S/D < 1.9 were regarded as elevated RAP. We also calculated the fibrosis 4 index (FIB-4) as a serum liver fibrosis marker. RESULTS: HV-SFF and SVC-S/D were feasible in 177 (92%) and 173 (90%) patients, respectively. In the 161 patients in whom both venous Doppler waveforms could be measured, HV-SFF and SVC-S/D were inversely correlated with RAP (r = -0.350, p < 0.001; r = -0.430, p < 0.001, respectively). SVC-S/D > 1.9 showed a significantly higher diagnostic accuracy of RAP elevation compared with HV-SFF < 55% (area under the curve, 0.842 vs. 0.614, p < 0.001). Multivariate analyses showed that both FIB-4 (β = -0.211, p = 0.013) and mean RAP (β = -0.319, p < 0.001) were independent determinants of HV-SFF. In contrast, not FIB-4 but mean RAP (β = -0.471, p < 0.001) was an independent determinant of SVC-S/D. The diagnostic accuracy remained unchanged when HV-SFF < 55% was considered in conjunction with the estimated RAP based on the inferior vena cava morphology. Conversely, SVC-S/D showed an incremental diagnostic value over the estimated RAP. CONCLUSIONS: SVC-S/D enabled a more accurate diagnosis of RAP elevation than HV-SFF.

肺動脈弁逆流速度計測に基づく右室一回仕事係数の非侵襲的推定法
立石優太; 村山迪史; 加賀早苗; 塚本真帆; 後藤真奈; 鈴木ゆき乃; 柳裕介; 横山しのぶ; 西野久雄; 石坂傑; 岩野弘幸; 安斉俊久
超音波検査技術, 49, 3, 271, 271, (一社)日本超音波検査学会, Jun. 2024
Japanese

Appropriate Body Position and Site for Diaphragm Ultrasound: Comparison with Inspiratory Mouth Pressure
Kazunori Okada; Akiko Kamiya; Yusuke Yanagi; Masahiro Nakabachi; Yasuhiro Hayashi; Michito Murayama; Sanae Kaga
WFUMB Ultrasound Open, 100052, 100052, Elsevier BV, Jun. 2024
Scientific journal

プラークだけじゃない! 頭頸部エコーでみられる典型画像巨細胞性動脈炎の診断に寄与する新たな超音波所見生検所見との比較に基づく検討
工藤悠輔; 村山迪史; 加賀早苗; 表原里実; 岩井孝仁; 進藤由衣香; 砂後谷華奈; 西田睦; 豊嶋崇徳; 石津明洋
超音波医学, 51, Suppl., S414, S414, (公社)日本超音波医学会, Apr. 2024
Japanese

健常人における門脈血流の拍動メカニズム肝静脈血流との比較に基づく検討
小野田愛梨; 村山迪史; 小林澄夏; 永井優衣; 塚本真帆; 阪口景太; 工藤悠輔; 加賀早苗
超音波医学, 51, Suppl., S524, S524, (公社)日本超音波医学会, Apr. 2024
Japanese

Deep learning to assess right ventricular ejection fraction from two-dimensional echocardiograms in precapillary pulmonary hypertension.
Michito Murayama; Hiroyuki Sugimori; Takaaki Yoshimura; Sanae Kaga; Hideki Shima; Satonori Tsuneta; Aoi Mukai; Yui Nagai; Shinobu Yokoyama; Hisao Nishino; Junichi Nakamura; Takahiro Sato; Ichizo Tsujino
Echocardiography (Mount Kisco, N.Y.), 41, 4, e15812, Apr. 2024, [International Magazine]
English, Scientific journal, BACKGROUND: Precapillary pulmonary hypertension (PH) is characterized by a sustained increase in right ventricular (RV) afterload, impairing systolic function. Two-dimensional (2D) echocardiography is the most performed cardiac imaging tool to assess RV systolic function; however, an accurate evaluation requires expertise. We aimed to develop a fully automated deep learning (DL)-based tool to estimate the RV ejection fraction (RVEF) from 2D echocardiographic videos of apical four-chamber views in patients with precapillary PH. METHODS: We identified 85 patients with suspected precapillary PH who underwent cardiac magnetic resonance imaging (MRI) and echocardiography. The data was divided into training (80%) and testing (20%) datasets, and a regression model was constructed using 3D-ResNet50. Accuracy was assessed using five-fold cross validation. RESULTS: The DL model predicted the cardiac MRI-derived RVEF with a mean absolute error of 7.67%. The DL model identified severe RV systolic dysfunction (defined as cardiac MRI-derived RVEF < 37%) with an area under the curve (AUC) of .84, which was comparable to the AUC of RV fractional area change (FAC) and tricuspid annular plane systolic excursion (TAPSE) measured by experienced sonographers (.87 and .72, respectively). To detect mild RV systolic dysfunction (defined as RVEF ≤ 45%), the AUC from the DL-predicted RVEF also demonstrated a high discriminatory power of .87, comparable to that of FAC (.90), and significantly higher than that of TAPSE (.67). CONCLUSION: The fully automated DL-based tool using 2D echocardiography could accurately estimate RVEF and exhibited a diagnostic performance for RV systolic dysfunction comparable to that of human readers.

Non-invasive assessment of left ventricular filling pressure in aortic stenosis.
Hiroyuki Aoyagi; Hiroyuki Iwano; Yoji Tamaki; Michito Murayama; Suguru Ishizaka; Ko Motoi; Kosuke Nakamura; Mana Goto; Yukino Suzuki; Shinobu Yokoyama; Hisao Nishino; Sanae Kaga; Kiwamu Kamiya; Toshiyuki Nagai; Toshihisa Anzai
Echocardiography (Mount Kisco, N.Y.), 41, 4, e15808, Apr. 2024, [International Magazine]
English, Scientific journal, BACKGROUND: The assessment of left ventricular (LV) filling pressure (FP) is important for the management of aortic stenosis (AS) patients. Although, it is often restricted for predict LV FP in AS because of mitral annular calcification and a certain left ventricular hypertrophy. Thus, we tested the predictive ability of the algorithm for elevated LV FP in AS patients and also applied a recently-proposed echocardiographic scoring system of LV FP, visually assessed time difference between the mitral valve and tricuspid valve opening (VMT) score. METHODS: We enrolled consecutive 116 patients with at least moderate AS in sinus rhythm who underwent right heart catheterization and echocardiography within 7 days. Mean pulmonary artery wedge pressure (PAWP) was measured as invasive parameter of LV FP. LV diastolic dysfunction (DD) was graded according to the ASE/EACVI guidelines. The VMT score was defined as follows: time sequence of opening of mitral and tricuspid valves was scored to 0-2 (0: tricuspid valve first, 1: simultaneous, 2: mitral valve first). When the inferior vena cava was dilated, one point was added and VMT score was finally calculated as 0-3. RESULTS: Of the 116 patients, 29 patients showed elevated PAWP. Ninety patients (93%) and 67 patients (63%) showed increased values for left atrium volume index (LAVI) and E/e', respectively when the cut-off values recommended by the guidelines were applied and thus the algorism predicted elevated PAWP with a low specificity and positive predictive value (PPV). VMT ≥ 2 predicted elevated PAWP with a sensitivity of 59%, specificity of 90%, PPV of 59%, and negative predictive value of 89%. An alternative algorithm that applied tricuspid regurgitation velocity and VMT scores was tested, and its predictive ability was markedly improved. CONCLUSION: VMT score was applicable for AS patients. Alternative use of VMT score improved diagnostic accuracy of guideline-recommended algorism.

Echocardiographic estimation of right ventricular diastolic stiffness based on pulmonary regurgitant velocity waveform analysis in precapillary pulmonary hypertension.
Yui Nagai; Michito Murayama; Sanae Kaga; Hideki Shima; Satonori Tsuneta; Shinobu Yokoyama; Hisao Nishino; Mana Goto; Yukino Suzuki; Yusuke Yanagi; Suguru Ishizaka; Hiroyuki Iwano; Junichi Nakamura; Takahiro Sato; Ichizo Tsujino
The international journal of cardiovascular imaging, 27 Mar. 2024, [International Magazine]
English, Scientific journal, Right ventricular (RV) diastolic stiffness is an independent predictor of survival and is strongly associated with disease severity in patients with precapillary pulmonary hypertension (PH). Therefore, a fully validated echocardiographic method for assessing RV diastolic stiffness needs to be established. This study aimed to compare echocardiography-derived RV diastolic stiffness and invasively measured pressure-volume loop-derived RV diastolic stiffness in patients with precapillary PH. We studied 50 consecutive patients with suspected or confirmed precapillary PH who underwent cardiac catheterization, magnetic resonance imaging, and echocardiography within a 1-week interval. Single-beat RV pressure-volume analysis was performed to determine the gold standard for RV diastolic stiffness. Elevated RV end-diastolic pressure (RVEDP) was defined as RVEDP ≥ 8 mmHg. Using continuous-wave Doppler and M-mode echocardiography, an echocardiographic index of RV diastolic stiffness was calculated as the ratio of the atrial-systolic descent of the pulmonary artery-RV pressure gradient derived from pulmonary regurgitant velocity (PRPGDAC) to the tricuspid annular plane movement during atrial contraction (TAPMAC). PRPGDAC/TAPMAC showed significant correlation with β (r = 0.54, p < 0.001) and RVEDP (r = 0.61, p < 0.001). A cut-off value of 0.74 mmHg/mm for PRPGDAC/TAPMAC showed 83% sensitivity and 93% specificity for identifying elevated RVEDP. Multivariate analyses indicated that PRPGDAC/TAPMAC was independently associated with disease severity in patients with precapillary PH, including substantial PH symptoms, stroke volume index, right atrial size, and pressure. PRPGDAC/TAPMAC, based on pulmonary regurgitation velocity waveform analysis, is useful for the noninvasive assessment of RV diastolic stiffness and is associated with prognostic risk factors in precapillary PH.

Correction: Venous dilation effect of hot towel (moist and dry heat) versus hot pack for peripheral intravenous catheterization: a quasi-experimental study.
Kae Yasuda; Inaho Shishido; Michito Murayama; Sanae Kaga; Rika Yano
Journal of physiological anthropology, 43, 1, 9, 9, 13 Feb. 2024, [International Magazine]
English

心エコー検査を契機に発見された先天性左側心膜欠損症の1症例
柳裕介; 加賀早苗; 村山迪史; 西野久雄; 横山しのぶ; 山下直樹; 玉置陽生; 青柳裕之; 石坂傑; 岩野弘幸; 豊嶋崇徳; 安斉俊久
超音波検査技術抄録集, 49, S198, S198, 一般社団法人日本超音波検査学会, 2024
Japanese

深層学習を用いた心尖部四腔像からの右室駆出率の推定
村山迪史; 加賀早苗; 向井葵; 永井優衣; 杉森博行; 吉村高明; 島秀起; 常田慧徳; 西野久雄; 中村順一; 佐藤隆博; 辻野一三
超音波検査技術抄録集, 49, S172, S172, 一般社団法人日本超音波検査学会, 2024
Japanese

Venous dilation effect of hot towel (moist and dry heat) versus hot pack for peripheral intravenous catheterization: a quasi-experimental study.
Kae Yasuda; Inaho Shishido; Michito Murayama; Sanae Kaga; Rika Yano
Journal of physiological anthropology, 42, 1, 23, 23, 19 Oct. 2023, [International Magazine]
English, Scientific journal, BACKGROUND: Heat application before peripheral intravenous catheterization is recommended for venous dilation. Hot pack application enlarges the venous diameter in healthy adults; however, hot towels (moist and dry heat) are used often in some medical cases. However, it is unclear whether hot towel application promotes venous dilation better than hot pack application. This study compared the venous dilation effect of using a hot towel (moist and dry heat) to a hot pack before applying the tourniquet at an access site for peripheral intravenous catheterization. METHODS: Eighty-eight healthy females aged 18-29 years were recruited for this quasi-experimental study. They underwent three types of heat applications (hot pack, moist hot towel, and dry hot towel [moist hot towel wrapped in a dry plastic bag], all of which were warmed to 40 ± 2 °C and performed for 7 min) to their forearm and tourniquet application for 30 s after each heating. Venous diameter and depth were measured using ultrasonography, and venous palpability and visibility (venous assessment score) was observed as venous dilatation effects. In addition, the skin temperature, stratum corneum hydration, and subjective evaluation of the warmth were measured. RESULTS: There were no significant differences in venous diameter and assessment scores after intervention between the dry hot towel and the hot pack groups, and the effect size was negligible (Cohen's d < 0.20). However, these measurements were significantly lower for the moist hot towel than for the other two heat applications (P < .001). Although there was no significant difference in skin temperature and warmth rating score between the dry hot towel and the hot pack, these were significantly lower for the moist hot towel than for the other two heat applications (P < .001). The amount of change in stratum corneum hydration of the dry hot towel was not significantly different from that of the hot pack; however, that of the moist hot towel was significantly larger than that of the other two heat applications (P < . 001.) CONCLUSIONS: A method in which a towel warmed in hot water is wrapped in a dry barrier may be an alternative to a hot pack. TRIAL REGISTRATION: This study was registered with University Hospital Medical Information Network in Japan (Registration No.: UMIN000048308. Registered on July 7, 2022).

Paradoxical increase in global longitudinal strain by handgrip exercise despite left ventricular diastolic dysfunction.
Ko Motoi; Hiroyuki Iwano; Suguru Ishizaka; Kosuke Nakamura; Yoji Tamaki; Hiroyuki Aoyagi; Masahiro Nakabachi; Shinobu Yokoyama; Hisao Nishino; Michito Murayama; Sanae Kaga; Toshihisa Anzai
Echocardiography (Mount Kisco, N.Y.), 40, 8, 810, 821, 14 Jul. 2023, [International Magazine]
English, Scientific journal, BACKGROUND: Although global longitudinal strain (GLS) is recognized as a sensitive marker of intrinsic left ventricular (LV) dysfunction, its afterload dependency has also been pointed. We hypothesized that decrease in GLS during handgrip exercise could be more sensitive marker of intrinsic myocardial dysfunction. METHODS: Handgrip exercise-stress echocardiography was performed in 90 cardiovascular disease patients with preserved LV ejection fraction. LV diastolic function was graded according to the guidelines. Diastolic wall stress (DWS) and ratio of left atrial (LA) volume index to late-diastolic mitral annular velocity (LAVI/a') were measured at rest as LV stiffness. As well, LA strains were measured to assess LA function. GLS was expressed as absolute value and significant changes in GLS by handgrip exercise was defined as changes over prespecified mean absolute test-retest variability (2.65%). RESULTS: While mean value of GLS did not change by the exercise, substantial patients showed significant changes in GLS: decreased (group I, n = 28), unchanged (group II, n = 34), and increased (group III, n = 28). Unexpectedly, patients in group I did not show any clinical and echocardiographic characteristics, while those in group III were characterized by elevated natriuretic peptide levels, blunted heart rate response to handgrip exercise, and advanced LV diastolic dysfunction. Multivariable analyses revealed that DWS, left atrial booster strain, and grade II or more diastolic dysfunction determined the increase in GLS even after adjustment for elevated natriuretic peptides and the changes in heart rate by the exercise. CONCLUSION: In contrast to our hypothesis, paradoxical increase in GLS by handgrip exercise could be associated with advanced LV diastolic dysfunction in cardiovascular patients with preserved LV ejection fraction. Our findings suggest that HG exercise for heart failure patients does not enhance the afterload straightforward, resulting in variable changes of GLS according to the individual conditions.

Application of an echocardiographic scoring system of left ventricular filling pressure to diagnose acute heart failure in patients complaining dyspnea.
Yoji Tamaki; Hiroyuki Iwano; Michito Murayama; Suguru Ishizaka; Ko Motoi; Hiroyuki Aoyagi; Kosuke Nakamura; Mana Goto; Yukino Suzuki; Shinobu Yokoyama; Hisao Nishino; Masahiro Nakabachi; Sanae Kaga; Kiwamu Kamiya; Toshiyuki Nagai; Toshihisa Anzai
Journal of cardiology, 82, 1, 62, 68, 27 Apr. 2023, [International Magazine]
English, Scientific journal, BACKGROUND: Dyspnea is a common symptom in acute heart failure (AHF) patients. Although an accurate and rapid diagnosis of AHF is essential to improve prognosis, estimation of left ventricular (LV) filling pressure (FP) remains challenging, especially for noncardiologists. We evaluated the usefulness of a recently-proposed parameter of LV FP, visually assessed time difference between the mitral valve and tricuspid valve opening (VMT) score, to detect AHF in patients complaining of dyspnea. METHODS: Echocardiography and lung ultrasonography (LUS) were performed in 121 consecutive patients (68 ± 14 years old, 75 males) presenting with dyspnea. The VMT score was determined from the atrioventricular valve opening phase (tricuspid valve first: 0, simultaneous: 1, mitral valve first: 2) and inferior vena cava dilatation (absent: 0, present: 1), and VMT ≥2 was judged as positive. LUS was performed with the 8 zones method and judged as positive if 3 or more B-lines were observed in bilateral regions. The AHF diagnosis was performed by certified cardiologists according to recent guidelines. RESULTS: Of the 121 patients, 33 were diagnosed with AHF. The sensitivity and specificity for diagnosing AHF were 64 % and 84 % for LUS and 94 % and 88 % for VMT score. In logistic regression analysis, VMT score showed a significantly higher c-index than LUS (0.91 vs 0.74, p = 0.002). In multivariable analyses, VMT score was associated with AHF independently of clinically relevant covariates and LUS. In addition, serial assessment of VMT score followed by LUS provided a diagnostic flow chart to diagnose AHF (VMT 3: AHF definitive, VMT 2 and LUS positive: AHF highly suspicious; VMT 2 and LUS negative: further investigation is needed; VMT ≤ 1: AHF rejected). CONCLUSIONS: VMT score showed high diagnostic accuracy in diagnosing AHF. Combined assessment of the VMT score and LUS could become a reliable strategy for diagnosis of AHF by non-cardiologists.

静脈血流速度波形分析に基づく右房圧推定に肝静脈と上大静脈のどちらが優れるか
村山迪史; 加賀早苗; 境田ひな; 小野田愛梨; 中鉢雅大; 西野久雄; 横山しのぶ; 石坂傑; 岩野弘幸; 安斉俊久
超音波医学, 50, Suppl., S740, S740, (公社)日本超音波医学会, Apr. 2023
Japanese

静脈血流速度波形分析に基づく右房圧推定に肝静脈と上大静脈のどちらが優れるか
村山迪史; 加賀早苗; 境田ひな; 小野田愛梨; 中鉢雅大; 西野久雄; 横山しのぶ; 石坂傑; 岩野弘幸; 安斉俊久
超音波医学, 50, Suppl., S740, S740, (公社)日本超音波医学会, Apr. 2023
Japanese

Impact of right ventricular stiffness on discordance between hemodynamic parameter and regurgitant volume in patients with pulmonary regurgitation.
Ko Motoi; Hiroyuki Iwano; Satonori Tsuneta; Suguru Ishizaka; Yoji Tamaki; Hiroyuki Aoyagi; Kosuke Nakamura; Michito Murayama; Masahiro Nakabachi; Shinobu Yokoyama; Hisao Nishino; Sanae Kaga; Atsuhito Takeda; Toshihisa Anzai
The international journal of cardiovascular imaging, 39, 6, 1133, 1142, 17 Mar. 2023, [International Magazine]
English, Scientific journal, BACKGROUND: Accurate detection of significant pulmonary regurgitation (PR) is critical in management of patients after right ventricular (RV) outflow reconstruction in Tetralogy of Fallot (TOF) patients, because of its influence on adverse outcomes. Although pressure half time (PHT) of PR velocity is one of the widely used echocardiographic markers of the severity, shortened PHT is suggested to be seen in conditions with increased RV stiffness with mild PR. However, little has been reported about the exact characteristics of patients showing discrepancy between PHT and PR volume in this population. METHODS: Echocardiography and cardiac magnetic resonance imaging (MRI) were performed in 74 TOF patients after right ventricular outflow tract (RVOT) reconstruction [32 ± 10 years old]. PHT was measured from the continuous Doppler PR flow velocity profile and PHT < 100 ms was used as a sign of significant PR. Presence of end-diastolic RVOT forward flow was defined as RV restrictive physiology. By using phase-contrast MRI, forward and regurgitant volumes through the RVOT were measured and regurgitation fraction was calculated. Significant PR was defined as regurgitant fraction ≥ 25%. RESULTS: Significant PR was observed in 54 of 74 patients. While PHT < 100 ms well predicted significant PR with sensitivity of 96%, specificity of 52%, and c-index of 0.72, 10 patients showed shortened PHT despite regurgitant fraction < 25% (discordant group). Tricuspid annular plane systolic excursion and left ventricular (LV) ejection fraction were comparable between discordant group and patients showing PHT < 100 ms and regurgitant fraction ≥ 25% (concordant group). However, discordant group showed significantly smaller mid RV diameter (30.7 ± 4.5 vs. 39.2 ± 7.3 mm, P < 0.001) and higher prevalence of restrictive physiology (100% vs. 42%, P < 0.01) than concordant group. When mid RV diameter ≥ 32 mm and presence of restrictive physiology were added to PHT, the predictive value was significantly improved (sensitivity: 81%, specificity: 90%, and c-index: 0.89, P < 0.001 vs. PHT alone by multivariable logistic regression model). CONCLUSION: Patients with increased RV stiffness and non-enlarged right ventricle showed short PHT despite mild PR. Although it has been expected, this was the first study to demonstrate the exact characteristics of patients showing discrepancy between PHT and PR volume in TOF patients after RVOT reconstruction.

大動脈弁狭窄症患者に対する左室充満圧の心エコースコアリングシステムの適用(Application of an Echocardiographic Scoring System of Left Ventricular Filling Pressure for Patients with Aortic Stenosis)
青柳裕之; 岩野弘幸; 後藤真奈; 鈴木ゆき乃; 村山迪史; 横山しのぶ; 西野久雄; 中鉢雅大; 中村公亮; 玉置陽生; 本居昂; 石坂傑; 加賀早苗; 神谷究; 永井利幸; 安斉俊久
日本循環器学会学術集会抄録集, 87回, PJ065, 2, (一社)日本循環器学会, Mar. 2023
English

心不全患者における複数の超音波指標を組み合わせたうっ血肝診断モデルの確立
小野田愛梨; 村山迪史; 加賀早苗; 中鉢雅大; 横山しのぶ; 西野久雄; 石坂傑; 本居昴; 青柳裕之; 玉置陽生; 中村公亮; 岩野弘幸; 安斉俊久
日本循環器学会学術集会抄録集, 87回, CO1, 3, (一社)日本循環器学会, Mar. 2023
Japanese

巨細胞性動脈炎の診断に寄与する新たな超音波所見生検所見との比較に基づく検討
工藤悠輔; 原花梨; 村山迪史; 加賀早苗; 表原里実; 岩井孝仁; 進藤由衣香; 菊池桃佳; 加藤将; 外丸詩野; 松野吉宏; 石津明洋
脈管学, 63, 1, 16, 16, (一社)日本脈管学会, Feb. 2023
Japanese

巨細胞性動脈炎の診断に寄与する新たな超音波所見生検所見との比較に基づく検討
工藤悠輔; 原花梨; 村山迪史; 加賀早苗; 表原里実; 岩井孝仁; 進藤由衣香; 菊池桃佳; 加藤将; 外丸詩野; 松野吉宏; 石津明洋
脈管学, 63, 1, 16, 16, (一社)日本脈管学会, Feb. 2023
Japanese

Validation of Echocardiographic Estimation of Right Atrial Pressure: Reconsideration of Guideline-Based Secondary Indices
Murayama Michito; Kaga Sanae; Onoda Airi; Okada Kazunori; Nakabachi Masahiro; Yokoyama Shinobu; Nishino Hisao; Aoyagi Hiroyuki; Tamaki Yoji; Motoi Ko; Ishizaka Suguru; Iwano Hiroyuki; Nagai Toshiyuki; Tsujino Ichizo; Anzai Toshihisa
Japanese Journal of Medical Ultrasound Technology, advpub, Japanese Society of Sonographers, 2023
Japanese, Purpose: Sonographic measurements of the inferior vena cava parameters are common noninvasive methods for estimating right atrial pressure. In intermediate cases in which the inferior vena cava parameters showed indeterminate value, the current guidelines of the American Society of Echocardiography recommended using secondary indices, which include restrictive right-sided diastolic filling pattern, the ratio of early-diastolic transtricuspid flow velocity to tricuspid annular velocity, and the hepatic venous systolic filling fraction. We aimed to clarify whether the above secondary indices improve the diagnostic ability of elevated right atrial pressure using inferior vena cava parameters and to test the incremental predictive value of right atrial area measurement.

Subjects and Methods: In 128 consecutive patients with various cardiac diseases referred for cardiac catheterization, the elevated right atrial pressure was defined as greater than or equal to 8 mmHg. Based on the inferior vena cava morphology, the estimated right atrial pressure was determined as 3, 8, and 15 mmHg (model 1). Additionally, the restrictive filling pattern, the ratio of early-diastolic transtricuspid flow velocity to tricuspid annular velocity, and the systolic filling fraction were evaluated to reclassify the intermediate value of 8 mmHg (model 2). The right atrial minimum and maximum area and volume were measured at ventricular end diastole and end systole, respectively, and the expansion indices were calculated.

Results: Elevated right atrial pressure was observed in 29 patients. Logistic regression analysis showed that estimated right atrial pressure based on the inferior vena cava indices and systolic filling fraction were significantly associated with elevated right atrial pressure (p＜0.05). Restrictive filling pattern was not observed in any of the patients, and the ratio of early-diastolic transtricuspid flow velocity to tricuspid annular velocity was not associated with elevated right atrial pressure. Right atrial morphological and functional parameters were significantly associated with elevated right atrial pressure (p＜0.05). Notably, the minimum right atrial area demonstrated the strongest association with right atrial pressure elevation (odds ratio adjusted for right ventricular systolic function: 10.64, p＜0.01). The predictive ability of model 2 was comparable to that of model 1 (global χ² value＝9 for model 1, 11 for model 2; p＝0.28). In contrast, incorporated with systolic filling fraction and minimal right atrial area as secondary indices, the predictive ability of the new model was improved compared to that of model 1 (global χ² value＝9 for model 1, 25 for the new model; p＜0.01).

Conclusion: Reclassification using guideline-recommended secondary indices failed to improve the predictive ability of elevated right atrial pressure. In contrast, a combination of systolic filling fraction and minimal right atrial area with inferior vena cava indices improved the predictive ability of elevated right atrial pressure.

Determinants of exercise capacity in patients with heart failure without left ventricular hypertrophy.
Suguru Ishizaka; Hiroyuki Iwano; Shingo Tsujinaga; Michito Murayama; Satonori Tsuneta; Hiroyuki Aoyagi; Yoji Tamaki; Ko Motoi; Yasuyuki Chiba; Asuka Tanemura; Masahiro Nakabachi; Shinobu Yokoyama; Hisao Nishino; Kazunori Okada; Brett A Meyers; Pavlos P Vlachos; Takuma Sato; Kiwamu Kamiya; Masaya Watanabe; Sanae Kaga; Toshiyuki Nagai; Noriko Oyama-Manabe; Toshihisa Anzai
Journal of cardiology, 81, 1, 33, 41, Jan. 2023, [International Magazine]
English, Scientific journal, BACKGROUND: Determinants of exercise intolerance in a phenotype of heart failure with preserved ejection fraction (HFpEF) with normal left ventricular (LV) structure have not been fully elucidated. METHODS: Cardiopulmonary exercise testing and exercise-stress echocardiography were performed in 44 HFpEF patients without LV hypertrophy. Exercise capacity was determined by peak oxygen consumption (peak VO2). Doppler-derived cardiac output (CO), transmitral E velocity, systolic (LV-s') and early diastolic mitral annular velocities (e'), systolic pulmonary artery (PA) pressure (SPAP), tricuspid annular plane systolic excursion (TAPSE), and peak systolic right ventricular (RV) free wall velocity (RV-s') were measured at rest and exercise. E/e' and TAPSE/SPAP were used as an LV filling pressure parameter and RV-PA coupling, respectively. RESULTS: During exercise, CO, LV-s', RV-s', e', and SPAP were significantly increased (p < 0.05 for all), whereas E/e' remained unchanged and TAPSE/SPAP was significantly reduced (p < 0.001). SPAP was higher and TAPSE/SPAP was lower at peak exercise in patients showing lower-half peak VO2. In univariable analyses, LV-s' (R = 0.35, p = 0.022), SPAP (R = -0.40, p = 0.008), RV-s' (R = 0.47, p = 0.002), and TAPSE/SPAP (R = 0.42, p = 0.005) were significantly correlated with peak VO2. In multivariable analyses, not only SPAP, but also TAPSE/SPAP independently determined peak VO2 even after the adjustment for clinically relevant parameters. CONCLUSIONS: In HFpEF patients without LV hypertrophy, altered RV-PA coupling by exercise could be associated with exercise intolerance, which might not be caused by elevated LV filling pressure.

Associations of right ventricular pulsatile load and cardiac power output to clinical outcomes in heart failure: Difference from systemic circulation.
Yasuyuki Chiba; Hiroyuki Iwano; Hiroyuki Aoyagi; Yoji Tamaki; Ko Motoi; Suguru Ishizaka; Michito Murayama; Shinobu Yokoyama; Masahiro Nakabachi; Hisao Nishino; Sanae Kaga; Kiwamu Kamiya; Toshiyuki Nagai; Toshihisa Anzai
Journal of cardiology, 81, 4, 404, 412, 08 Dec. 2022, [International Magazine]
English, Scientific journal, BACKGROUND: Although left ventricular (LV) cardiac power output (CPO) is a powerful prognostic indicator in heart failure (HF), the significance of right ventricular (RV) CPO is unknown. In contrast, RV pulsatile load is a key prognostic marker in HF. We investigated the impact of RV-CPO and pulsatile load on cardiac outcome and the prognostic performance of the combined systemic and pulmonary circulation parameters in HF. METHODS: Right heart catheterization and echocardiography were performed in 231 HF patients (62 ± 16 years, LV ejection fraction 42 ± 18 %). Invasive and noninvasive CPOs were calculated from mean systemic or pulmonary arterial pressure and cardiac output. LV-CPO was then normalized to LV mass (LV-P/M). Pulmonary arterial capacitance and the ratio of acceleration time to ejection time (AcT/ET) of RV outflow were used as parameters of RV pulsatile load. The primary endpoints, defined as a composite of cardiac death, HF hospitalization, ventricular arrythmia, and LVAD implantation after the examination, were recorded. RESULTS: Noninvasive CPOs were moderately correlated with invasive ones (LV: ρ = 0.787, RV: ρ = 0.568, and p < 0.001 for both). During a median follow-up period of 441 days, 57 cardiovascular events occurred. Lower LV-P/M and higher RV pulsatile load were associated with cardiovascular events; however, RV-CPO was not associated with the outcome. Echocardiographic LV-P/M and AcT/ET showed significant incremental prognostic value over the clinical parameters. CONCLUSIONS: RV pulsatile load assessed by AcT/ET may be a predictor of clinical events in HF patients. The combination of echocardiographic LV-P/M and AcT/ET could be a novel noninvasive prognostic indicator in HF patients.

Evaluation of two semi-supervised learning methods and their combination for automatic classification of bone marrow cells
Iori Nakamura; Haruhi Ida; Mayu Yabuta; Wataru Kashiwa; Maho Tsukamoto; Shigeki Sato; Syuichi Ota; Naoki Kobayashi; Hiromi Masauzi; Kazunori Okada; Sanae Kaga; Keiko Miwa; Hiroshi Kanai; Nobuo Masauzi
Scientific Reports, 12, 1, Springer Science and Business Media LLC, 06 Oct. 2022
Scientific journal, Abstract

Differential bone marrow (BM) cell counting is an important test for the diagnosis of various hematological diseases. However, it is difficult to accurately classify BM cells due to non-uniformity and the lack of reproducibility of differential counting. Therefore, automatic classification systems have been developed in which deep learning is used. These systems requires large and accurately labeled datasets for training. To overcome this, we used semi-supervised learning (SSL), in which learning proceeds while labeling. We used three methods: self-training (ST), active learning (AL), and a combination of these methods, and attempted to automatically classify 16 types of BM cell images. ST involves data verification, as in AL, before adding them to the training dataset (confirmed self-training: CST). After 25 rounds of CST, AL, and CST + AL, the initial number of training data increased from 425 to 40,518; 3682; and 47,843, respectively. Accuracies for the test data of 50 images for each cell type were 0.944, 0.941, and 0.976, respectively. Data added with CST or AL showed some imbalances between classes, while CST + AL exhibited fewer imbalances. We suggest that CST + AL, when combined with two SSL methods, is efficient in increasing training data for the development of automatic BM cells classification systems.

Usefulness of Dual Gate Doppler in Assessing the Time Interval Between Pulmonary Venous and Transmitral Flows During Atrial Contraction
Okada Kazunori; Okada Yuka; Murayama Michito; Kaga Sanae; Masauzi Nobuo; Nishino Hisao; Yokoyama Shinobu; Nakabachi Masahiro; Nishida Mutsumi; Motoi Ko; Ishizaka Suguru; Chiba Yasuyuki; Tsujinaga Shingo; Iwano Hiroyuki; Anzai Toshihisa
Japanese Journal of Medical Ultrasound Technology, 47, 4, 353, 362, Japanese Society of Sonographers, 01 Aug. 2022
Japanese, Purpose: The difference in duration between pulmonary venous (PV) atrial systolic reversal wave (PVA) and atrial systolic wave (A) of transmitral flow (ΔA_dur) reflects the late-diastolic left ventricular (LV) operating stiffness and has a limitation on reproducibility. Using the Dual Gate Doppler technique, simultaneous recording of PV and transmitral flows can be obtained, which may contribute to improving the accuracy and reproducibility of ΔA_dur measurements.

Methods and Results: We examined 80 patients who underwent echocardiography using Dual Gate Doppler recording. Using the conventional Doppler recording, we measured the difference in duration between the PVA and transmitral A-wave (S-ΔA_dur). Additionally, the ratio of the time–velocity integral (TVI) of the PVA to that of the whole PV flow (F_PVA) and the ratio of the TVI in transmitral A-wave of the whole transmitral flow (F_A) were calculated, and F_PVA/F_A was obtained as an index of LV operating stiffness. From the Dual Gate Doppler recording of PV and transmitral flows, we measured ΔA_dur (D-ΔA_dur) and time from the end of transmitral A-wave to the end of PVA (D-ΔA_end).

Results: Each of S-ΔA_dur, D-ΔA_dur, and D-ΔA_end significantly correlated with F_PVA/F_A (r＝0.50, 0.51, and 0.71, respectively), and the correlation between F_PVA/F_A and D-ΔA_end was significantly greater than that between F_PVA/F_A and S-ΔA_dur and between F_PVA/F_A and D-ΔA_dur (p＜0.001 for both). The intraclass correlation coefficients for the inter- and intra-observer comparisons were excellent for D-ΔA_end, adequate for D-ΔA_dur, and fair for S-ΔA_dur.

Conclusion: Dual Gate Doppler-derived D-ΔA_end has higher reproducibility and usefulness for assessing late-diastolic LV operating stiffness than the conventional Doppler-derived S-ΔA_dur.

Usefulness of the pulmonary venous flow waveform for assessing left atrial stiffness
Takehiro Abe; Kazunori Okada; Michito Murayama; Sanae Kaga; Masahiro Nakabachi; Shinobu Yokoyama; Hisao Nishino; Hiroyuki Aoyagi; Yoji Tamaki; Ko Motoi; Yasuyuki Chiba; Suguru Ishizaka; Shingo Tsujinaga; Hiroyuki Iwano; Kiwamu Kamiya; Toshiyuki Nagai; Toshihisa Anzai
The International Journal of Cardiovascular Imaging, Springer Science and Business Media LLC, 16 Jul. 2022
Scientific journal

Visual echocardiographic scoring system of the left ventricular filling pressure and outcomes of heart failure with preserved ejection fraction.
Michito Murayama; Hiroyuki Iwano; Masaru Obokata; Tomonari Harada; Kazunori Omote; Kazuki Kagami; Shingo Tsujinaga; Yasuyuki Chiba; Suguru Ishizaka; Ko Motoi; Yoji Tamaki; Hiroyuki Aoyagi; Masahiro Nakabachi; Hisao Nishino; Shinobu Yokoyama; Asuka Tanemura; Kazunori Okada; Sanae Kaga; Mutsumi Nishida; Toshiyuki Nagai; Masahiko Kurabayashi; Toshihisa Anzai
European heart journal. Cardiovascular Imaging, 23, 5, 616, 626, 18 Apr. 2022, [International Magazine]
English, Scientific journal, AIMS: Elevated left ventricular filling pressure (LVFP) is a powerful indicator of worsening clinical outcomes in heart failure with preserved ejection fraction (HFpEF); however, detection of elevated LVFP is often challenging. This study aimed to determine the association between the newly proposed echocardiographic LVFP parameter, visually assessed time difference between the mitral valve and tricuspid valve opening (VMT) score, and clinical outcomes of HFpEF. METHODS AND RESULTS: We retrospectively investigated 310 well-differentiated HFpEF patients in stable conditions. VMT was scored from 0 to 3 using two-dimensional echocardiographic images, and VMT ≥2 was regarded as a sign of elevated LVFP. The primary endpoint was a composite of cardiac death or heart failure hospitalization during the 2 years after the echocardiographic examination. In all patients, Kaplan-Meier curves showed that VMT ≥2 (n = 54) was associated with worse outcomes than the VMT ≤1 group (n = 256) (P < 0.001). Furthermore, VMT ≥2 was associated with worse outcomes when tested in 100 HFpEF patients with atrial fibrillation (AF) (P = 0.026). In the adjusted model, VMT ≥2 was independently associated with the primary outcome (hazard ratio 2.60, 95% confidence interval 1.46-4.61; P = 0.001). Additionally, VMT scoring provided an incremental prognostic value over clinically relevant variables and diastolic function grading (χ2 10.8-16.3, P = 0.035). CONCLUSIONS: In patients with HFpEF, the VMT score was independently and incrementally associated with adverse clinical outcomes. Moreover, it could also predict clinical outcomes in HFpEF patients with AF.

前毛細管性肺高血圧症における心筋遅延造影像と左室収縮障害との関連
新川未緒; 加賀早苗; 岩野弘幸; 千葉泰之; 宮本知佳; 岡田一範; 村山迪史; 中鉢雅大; 常田慧徳; 辻野一三
超音波医学, 49, Suppl., S706, S706, (公社)日本超音波医学会, Apr. 2022
Japanese

Difference in left atrial myocardial dynamics during reservoir phase between hypertrophic cardiomyopathy and hypertensive heart determined using three-dimensional speckle tracking echocardiography
Yusuke Yanagi; Kazunori Okada; Sanae Kaga; Taisei Mikami; Miho Aiba; Nobuo Masauzi; Michito Murayama; Asuka Tanemura; Shinobu Yokoyama; Hisao Nishino; Masahiro Nakabachi; Yoji Tamaki; Hiroyuki Aoyagi; Ko Motoi; Suguru Ishizaka; Yasuyuki Chiba; Shingo Tsujinaga; Hiroyuki Iwano; Toshihisa Anzai
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING, Apr. 2022
English, Scientific journal

Prognostic value of an echocardiographic index reflecting right ventricular operating stiffness in patients with heart failure.
Ryosuke Fujisawa; Kazunori Okada; Sanae Kaga; Michito Murayama; Masahiro Nakabachi; Shinobu Yokoyama; Hisao Nishino; Asuka Tanemura; Nobuo Masauzi; Ko Motoi; Suguru Ishizaka; Yasuyuki Chiba; Shingo Tsujinaga; Hiroyuki Iwano; Toshihisa Anzai
Heart and vessels, 37, 4, 583, 592, Apr. 2022, [Domestic magazines]
English, Scientific journal, PURPOSE: We recently reported a noninvasive method for the assessment of right ventricular (RV) operating stiffness that is obtained by dividing the atrial-systolic descent of the pulmonary artery-RV pressure gradient (PRPGDAC) derived from the pulmonary regurgitant velocity by the tricuspid annular plane movement during atrial contraction (TAPMAC). Here, we investigated whether this parameter of RV operating stiffness, PRPGDAC/TAPMAC, is useful for predicting the prognosis of patients with heart failure (HF). METHODS: We retrospectively included 127 hospitalized patients with HF who underwent an echocardiographic examination immediately pre-discharge. The PRPGDAC/TAPMAC was measured in addition to standard echocardiographic parameters. Patients were followed until 2 years post-discharge. The endpoint was the composite of cardiac death, readmission for acute decompensation, and increased diuretic dose due to worsening HF. RESULTS: 58 patients (46%) experienced the endpoint during follow-up. Univariable and multivariable Cox regression analyses demonstrated that the PRPGDAC/TAPMAC was associated with the endpoint. In a Kaplan-Meier analysis, the event rate of the greater PRPGDAC/TAPMAC group was significantly higher than that of the lesser PRPGDAC/TAPMAC group. In a sequential Cox analysis for predicting the endpoint's occurrence, the addition of PRPGDAC/TAPMAC to the model including age, sex, NYHA functional classification, brain natriuretic peptide level, and several echocardiographic parameters including tricuspid annular plane systolic excursion significantly improved the predictive power for prognosis. CONCLUSION: A completely noninvasive index of RV operating stiffness, PRPGDAC/TAPMAC, was useful for predicting prognoses in patients with HF, and it showed an incremental prognostic value over RV systolic function.

Clinical Utility of Superior Vena Cava Flow Velocity Waveform Measured from the Subcostal Window for Estimating Right Atrial Pressure.
Michito Murayama; Sanae Kaga; Kazunori Okada; Hiroyuki Iwano; Masahiro Nakabachi; Shinobu Yokoyama; Hisao Nishino; Shingo Tsujinaga; Yasuyuki Chiba; Suguru Ishizaka; Ko Motoi; Kiwamu Kamiya; Mutsumi Nishida; Toshiyuki Nagai; Toshihisa Anzai
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 35, 7, 727, 737, 09 Feb. 2022, [International Magazine]
English, Scientific journal, BACKGROUND: The superior vena cava (SVC) flow velocity waveform from the supraclavicular window reflects right atrial pressure (RAP) status. Recent guidelines have stated that the subcostal window is an alternative view for recording SVC flow, but the validity of this approach remains unclear. The aim of this study was to determine the usefulness of SVC flow evaluation from the subcostal window for estimating RAP. METHODS: Differences in SVC flow characteristics between opposite approaches were examined in 38 healthy adults. In 115 patients with cardiovascular diseases who underwent cardiac catheterization and echocardiography within 48 hours, the ratio of peak systolic to diastolic forward SVC flow (SVC-S/D) was measured, and the diagnostic ability of SVC-S/D for elevated RAP was tested. A validation cohort was used to confirm the diagnostic ability of SVC-S/D in 48 patients who underwent both cardiac catheterization and echocardiography within 24 hours. In 59 patients in the derivation and validation cohorts, the relationship between SVC flow and RAP was compared between the opposite windows. RESULTS: Both systolic and diastolic SVC flow velocities were higher in the subcostal than in the supraclavicular approach, and effect of position change on subcostal SVC-S/D was smaller than that on supraclavicular SVC-S/D in healthy adults. Measurement of SVC-S/D from the subcostal window was feasible in 98 patients (85%). RAP was inversely correlated with SVC-S/D (r = -0.50, P < .001) and was an independent determinant of SVC-S/D after adjustment for right ventricular systolic function (β = -0.48, P < .001). A cutoff value of 1.9 for SVC-S/D showed 85% sensitivity and 74% specificity in identifying elevated RAP. Additionally, SVC-S/D showed an incremental diagnostic value combined with inferior vena cava size and collapsibility (P = .006). When a cutoff value of SVC-S/D < 1.9 was applied to the validation cohort, it showed acceptable accuracy of 72% and incremental diagnostic value combined with inferior vena cava parameters (P = .033). SVC-S/D from the subcostal window correlated better with RAP than that from the supraclavicular window (P < .001, Meng's test). CONCLUSIONS: Measurement of SVC flow velocity from the subcostal window was feasible, and SVC-S/D from the subcostal window could be an additive parameter for estimating RAP.

Determinants of altered left ventricular suction in pre-capillary pulmonary hypertension.
Yasuyuki Chiba; Hiroyuki Iwano; Satonori Tsuneta; Shingo Tsujinaga; Brett Meyers; Pavlos Vlachos; Suguru Ishizaka; Ko Motoi; Hiroyuki Aoyagi; Yoji Tamaki; Asuka Tanemura; Michito Murayama; Shinobu Yokoyama; Masahiro Nakabachi; Hisao Nishino; Sanae Kaga; Kiwamu Kamiya; Hiroshi Ohira; Ichizo Tsujino; Toshihisa Anzai
European heart journal. Cardiovascular Imaging, 23, 10, 1399, 1406, 10 Jan. 2022, [International Magazine]
English, Scientific journal, AIMS: Although the left ventricular (LV) dysfunction in pre-capillary pulmonary hypertension (PH) has been recently recognized, the mechanism of LV dysfunction in this entity is not completely understood. We thus aimed to elucidate the determinants of intraventricular pressure difference (IVPD), a measure of LV suction, in pre-capillary PH. METHODS AND RESULTS: Right heart catheterization and echocardiography were performed in 86 consecutive patients with pre-capillary PH (57 ± 18 years, 85% female). IVPD was determined using colour M-mode Doppler to integrate the Euler equation. In overall, IVPD was reduced compared to previously reported value in normal subjects. In univariable analyses, QRS duration (P = 0.028), LV ejection fraction (P = 0.006), right ventricular (RV) end-diastolic area (P < 0.001), tricuspid annular plane systolic excursion (P = 0.004), and LV early-diastolic eccentricity index (P = 0.009) were associated with IVPD. In the multivariable analyses, RV end-diastolic area and LV eccentricity index independently determined the IVPD. CONCLUSION: Aberrant ventricular interdependence caused by RV enlargement could impair the LV suction. This study first applied echocardiographic IVPD, a reliable marker of LV diastolic suction, to investigate the mechanism of LV diastolic dysfunction in pre-capillary PH.

ドプラ心エコー法による肺動脈弁逆流重症度の過大評価の要因に関する検討
本居昂; 岩野弘幸; 常田慧徳; 村山迪史; 加賀早苗; 青柳裕之; 玉置陽生; 石坂傑; 千葉泰之; 辻永真吾; 種村明日香; 横山しのぶ; 中鉢雅大; 西野久雄; 岡田一範; 武田充人; 安斉俊久
日本成人先天性心疾患学会雑誌, 11, 1, 216, 216, 日本成人先天性心疾患学会, Jan. 2022
Japanese

Influence of left ventricular systolic dysfunction on occurrence of pulsus tardus in patients with aortic stenosis.
Suguru Ishizaka; Hiroyuki Iwano; Ko Motoi; Yasuyuki Chiba; Shingo Tsujinaga; Asuka Tanemura; Michito Murayama; Masahiro Nakabachi; Shinobu Yokoyama; Hisao Nishino; Kazunori Okada; Sanae Kaga; Kiwamu Kamiya; Toshiyuki Nagai; Toshihisa Anzai
Journal of cardiology, 78, 4, 322, 327, Oct. 2021, [International Magazine]
English, Scientific journal, BACKGROUND: Although the time difference between peak of left ventricular (LV) and aortic systolic pressures (TLV-Ao), which is considered to in part reflect pulsus tardus, is reported to be associated with clinical outcome in aortic stenosis (AS), its physiological determinants remain to be elucidated. We hypothesized that not only AS severity but also LV systolic dysfunction could be associated with occurrence of pulsus tardus. METHODS: TLV-Ao was measured by simultaneous LV and aortic pressure tracing in 74 AS patients and prolonged TLV-Ao was defined as ≥66 ms according to the previous report. Mean transaortic valvular pressure gradient (mPG) and effective orifice area index (EOAI) were estimated by Doppler echocardiography and severe AS was defined as EOAI ≤0.60 cm2/m2. Global longitudinal strain (GLS) was measured by using speckle-tracking method. RESULTS: Although a weak correlation was observed between EOAI and TLV-Ao, there was substantial population showing discordance between the parameters: severe AS despite normal TLV-Ao (10 of 47 patients) and moderate AS despite prolonged TLV-Ao (9 of 17 patients). In severe AS, mPG was significantly higher in patients showing prolonged TLV-Ao (57±20 vs 36±10 mmHg, p<0.0001) whereas GLS was comparable between the groups (-15.2±3.5% vs -14.8±3.2%). In contrast, in moderate AS, GLS was significantly smaller in patients showing prolonged TLV-Ao (-12.6±4.7% vs -17.4±3.4%, p=0.0271) while mPG was comparable (34±7 mmHg vs 35±8 mmHg). Multivariable analysis revealed that not only mPG but also GLS was an independent determinant of TLV-Ao. CONCLUSIONS: The occurrence of pulsus tardus could be associated with not only AS severity but also LV systolic dysfunction in AS patients.

Application of the proximal isovelocity surface area method for estimation of the effective orifice area in aortic stenosis.
Masahiro Nakabachi; Hiroyuki Iwano; Michito Murayama; Hisao Nishino; Shinobu Yokoyama; Shingo Tsujinaga; Yasuyuki Chiba; Suguru Ishizaka; Ko Motoi; Kazunori Okada; Sanae Kaga; Mutsumi Nishida; Takanori Teshima; Toshihisa Anzai
Heart and vessels, 37, 4, 638, 646, 25 Sep. 2021, [Domestic magazines]
English, Scientific journal, Although the echocardiographic effective orifice area (EOA) calculated using the continuity equation is widely used for the assessment of severity in aortic stenosis (AS), the existence of high flow velocity at the left ventricular outflow tract (LVOT) potentially causes its overestimation. The proximal isovelocity surface area (PISA) method could be an alternative tool for the estimation of EOA that limits the influence of upstream flow velocity. EOA was calculated using the continuity equation (EOACont) and PISA method (EOAPISA), respectively, in 114 patients with at least moderate AS. The geometric orifice area (GOA) was also measured using the planimetry method in 51 patients who also underwent three-dimensional transesophageal echocardiography. Patients were divided into two groups according to the median LVOT flow velocity. EOAPISA could be obtained in 108 of the 114 patients (95%). Although there was a strong correlation between EOACont and EOAPISA (r = 0.78, P < 0.001), EOACont was statistically significantly larger than EOAPISA (0.86 ± 0.33 vs 0.75 ± 0.29 cm2, P < 0.001). Both EOACont and EOAPISA similarly correlated with GOA (r = 0.70, P < 0.001 and r = 0.77, P < 0.001, respectively). However, a fixed bias, which is hydrodynamically supposed to exist between EOA and GOA, was not observed between EOACont and GOA. In contrast, there was a negative fixed bias between EOAPISA and GOA with smaller EOAPISA than GOA. The difference between EOACont and GOA was significantly greater with a larger EOACont relative to GOA in patients with high LVOT flow velocity than in those without (0.16 ± 0.25 vs - 0.07 ± 0.10 cm2, P < 0.001). In contrast, the difference between EOAPISA and GOA was consistent regardless of the LVOT flow velocity (- 0.07 ± 0.12 vs - 0.07 ± 0.15 cm2, P = 0.936). The PISA method was applied to estimate EOA in patients with AS. EOAPISA could be an alternative parameter for AS severity grading in patients with high LVOT flow velocity in whom EOACont would potentially overestimate the orifice area.

慢性心不全における右室cardiac power outputの意義
千葉泰之; 岩野弘幸; 本居昂; 石坂傑; 辻永真吾; 村山迪史; 横山しのぶ; 中鉢雅大; 西野久雄; 岡田一範; 加賀早苗; 神谷究; 永井利幸; 安斉俊久
日本心臓病学会学術集会抄録, 69回, O, 029, (一社)日本心臓病学会, Sep. 2021
Japanese

Simple Two-Dimensional Echocardiographic Scoring System for the Estimation of Left Ventricular Filling Pressure.
Michito Murayama; Hiroyuki Iwano; Hisao Nishino; Shingo Tsujinaga; Masahiro Nakabachi; Shinobu Yokoyama; Miho Aiba; Kazunori Okada; Sanae Kaga; Miwa Sarashina; Yasuyuki Chiba; Suguru Ishizaka; Ko Motoi; Mutsumi Nishida; Hitoshi Shibuya; Kiwamu Kamiya; Toshiyuki Nagai; Toshihisa Anzai
Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 34, 7, 723, 734, Jul. 2021, [International Magazine]
English, Scientific journal, BACKGROUND: When left ventricular filling pressure (LVFP) increases, the mitral valve opens early and precedes tricuspid valve opening in early diastole. The authors hypothesized that a visually assessed time sequence of atrioventricular valve opening could become a new marker of elevated LVFP. The aim of this study was to test the diagnostic ability of a novel echocardiographic scoring system, the visually assessed time difference between mitral valve and tricuspid valve opening (VMT) score, in patients with heart failure. METHODS: One hundred nineteen consecutive patients who underwent cardiac catheterization within 24 hours of echocardiographic examination were retrospectively analyzed as a derivation cohort. In addition, a prospective study was conducted to validate the diagnostic ability of the VMT score in 50 patients. Elevated LVFP was defined as mean pulmonary artery wedge pressure (PAWP) ≥ 15 mm Hg. The time sequence of atrioventricular valve opening was visually assessed and scored (0 = tricuspid valve first, 1 = simultaneous, 2 = mitral valve first). When the inferior vena cava was dilated, 1 point was added, and VMT score was ultimately graded as 0 to 3. Cardiac events were recorded for 1 year after echocardiography. RESULTS: In the derivation cohort, PAWP was elevated with higher VMT scores (score 0, 10 ± 5; score 1, 12 ± 4; score 2, 22 ± 8; score 3, 28 ± 4 mm Hg; P < .001, analysis of variance). VMT score ≥ 2 predicted elevated PAWP with accuracy of 86% and showed incremental predictive value over clinical variables and guideline-recommended diastolic function grading. These observations were confirmed in the prospective validation cohort. Importantly, VMT score ≥ 2 discriminated elevated PAWP with accuracy of 82% in 33 patients with monophasic left ventricular inflow in the derivation cohort. Kaplan-Meier analysis demonstrated that patients with VMT scores ≥ 2 were at higher risk for cardiac events than those with VMT scores ≤ 1 (P < .001). CONCLUSIONS: VMT scoring could be a novel additive marker of elevated LVFP and might also be associated with adverse outcomes in patients with heart failure.

Functional significance of intra-left ventricular vortices on energy efficiency in normal, dilated, and hypertrophied hearts.
Miwa Sarashina-Motoi; Hiroyuki Iwano; Ko Motoi; Suguru Ishizaka; Yasuyuki Chiba; Shingo Tsujinaga; Michito Murayama; Masahiro Nakabachi; Shinobu Yokoyama; Hisao Nishino; Kazunori Okada; Sanae Kaga; Toshihisa Anzai
Journal of clinical ultrasound : JCU, 49, 4, 358, 367, May 2021, [International Magazine]
English, Scientific journal, PURPOSE: To investigate the influence of changes in vortices within the left ventricle (LV) on energy efficiency (EE) in normal and diseased hearts. METHODS: We performed vector flow mapping echocardiography in 36 normal participants (N), 36 patients with dilated cardiomyopathy (D), and 36 patients with LV hypertrophy (H). The circulation of the main anterior vortex was measured as a parameter of vortex strength. Energy loss (EL) was measured for one cardiac cycle, and EE was calculated as EL divided by stroke work (SW), which represents the loss of kinetic energy per unit of LV external work. RESULTS: Circulation increased in the order of N, H, and D (N: 15 ± 4, D: 19 ± 8, H: 17 ± 6 × 10-3 m2 /s; analysis of variance [ANOVA] P < .01). Conversely, EE increased in the order of N, D, and H (N: 0.22 ± 0.07, D: 0.26 ± 0.16, H: 0.30 ± 0.16 10-5 J/mm Hg mL m s; ANOVA P = .04), suggesting worst EE in group H. We found a positive correlation between circulation and SW only in group N, and positive correlation between circulation and EE only in diseased groups (D: R = 0.55, P < .01; H: R = 0.44, P < .01). Multivariable analyses revealed that circulation was the independent determinant of EE in groups D and H. CONCLUSIONS: Enhanced vortices could be associated with effective increase in LV external work in normal hearts. Conversely, they were associated with loss of EE without an optimal increase in external work in failing hearts, regardless of the LV morphology.

拡張機能学再考:beyond E/E' 時相解析に基づく新たな左室充満圧推定指標僧帽弁輪石灰化例、心房細動例への適用
岩野弘幸; 村山迪史; 辻永真吾; 千葉泰之; 石坂傑; 本居昂; 中鉢雅大; 加賀早苗; 安斉俊久
超音波医学, 48, Suppl., S205, S205, (公社)日本超音波医学会, Apr. 2021
Japanese

右房圧の推定に用いられる超音波指標の精度比較
小野田愛梨; 村山迪史; 加賀早苗; 岡田一範; 相庭美穂; 藤澤亮介; 中鉢雅大; 横山しのぶ; 西野久雄; 西田睦; 岩野弘幸; 安斉俊久
超音波検査技術抄録集, 46, S197, S197, 一般社団法人日本超音波検査学会, 2021
Japanese

上大静脈血流速度波形計測における心窩部アプローチの有用性
村山迪史; 加賀早苗; 岡田一範; 中鉢雅大; 西野久雄; 横山しのぶ; 種村明日香; 石坂傑; 千葉泰之; 辻永真吾; 西田睦; 岩野弘幸
超音波検査技術抄録集, 46, S136, S136, 一般社団法人日本超音波検査学会, 2021
Japanese

混合性肺高血圧症を合併する心不全患者の左房機能と予後との関連
後藤真奈; 加賀早苗; 岡田一範; 相庭美穂; 藤澤亮介; 村山迪史; 中鉢雅大; 西野久雄; 横山しのぶ; 種村明日香; 辻永真吾; 岩野弘幸
超音波検査技術抄録集, 46, S135, S135, 一般社団法人日本超音波検査学会, 2021
Japanese

心内圧波形に基づく拡張早期僧帽弁逆流の発生機序に関する考察
種村明日香; 村山迪史; 岩野弘幸; 西野久雄; 横山しのぶ; 中鉢雅大; 本居昂; 辻永真吾; 岡田一範; 加賀早苗; 西田睦; 豊嶋崇徳
超音波検査技術抄録集, 46, S132, S132, 一般社団法人日本超音波検査学会, 2021
Japanese

Deep Learning-Based Nuclear Lobe Count Method for Differential Count of Neutrophils
Mayu Yabuta; Iori Nakamura; Haruhi Ida; Hiromi Masauzi; Kazunori Okada; Sanae Kaga; Keiko Miwa; Nobuo Masauzi
The Tohoku Journal of Experimental Medicine, 254, 3, 199, 206, Tohoku University Medical Press, 2021
Scientific journal

Influence of advanced pulmonary vascular remodeling on accuracy of echocardiographic parameters of left ventricular filling pressure
Yasuyuki Chiba; Hiroyuki Iwano; Sanae Kaga; Mio Shinkawa; Michito Murayama; Hiroshi Ohira; Suguru Ishizaka; Miwa Sarashina; Shingo Tsujinaga; Shinobu Yokoyama; Masahiro Nakabachi; Hisao Nishino; Kazunori Okada; Kiwamu Kamiya; Toshiyuki Nagai; Toshihisa Anzai
Pulmonary Circulation, 11, 1, 204589402098372, 204589402098372, SAGE Publications, Jan. 2021
Scientific journal, Evaluation of left ventricular filling pressure plays an important role in the clinical management of pulmonary hypertension. However, the accuracy of echocardiographic parameters for the determination of left ventricular filling pressure in the presence of pulmonary vascular lesions has not been fully addressed. We retrospectively investigated 124 patients with pulmonary hypertension due to pulmonary vascular lesions (noncardiac pulmonary hypertension group) and 113 patients with ischemic heart disease (control group) who underwent right heart catheterization and echocardiography. The noncardiac pulmonary hypertension group was subdivided into less-advanced and advanced groups according to median pulmonary vascular resistance. Pulmonary artery wedge pressure was determined as left ventricular filling pressure. As echocardiographic parameters of left ventricular filling pressure, the ratio of early- (E) to late-diastolic transmitral flow velocity (E/A), ratio of E to early-diastolic mitral annular velocity (E/e′), and left atrial volume index were measured. In the less-advanced noncardiac pulmonary hypertension and control groups, positive correlations were observed between pulmonary artery wedge pressure and late-diastolic transmitral flow velocity ( R = 0.41, P = 0.002 and R = 0.71, P < 0.001, respectively) and left atrial volume index ( R = 0.53, P < 0.001 and R = 0.41, P < 0.001), whereas in the advanced noncardiac pulmonary hypertension group, pulmonary artery wedge pressure was only correlated with left atrial volume index ( R = 0.27, P = 0.032). In the controls, only pulmonary artery wedge pressure determined E (β = 0.48, P < 0.001), whereas both pulmonary artery wedge pressure and pulmonary vascular resistance were independent determinants of E (β = 0.29, P < 0.001 and β = –0.28, P = 0.001, respectively) in the noncardiac pulmonary hypertension group. In conclusion, in the presence of advanced pulmonary vascular lesions, conventional echocardiographic parameters may not accurately reflect left ventricular filling pressure. Elevated pulmonary vascular resistance would lower the E, even when pulmonary artery wedge pressure is elevated, resulting in blunting of echocardiographic parameters for the detection of elevated left ventricular filling pressure.

Presence and Relevance of Midsystolic Notching on Right Ventricular Outflow Tract Flow Velocity Envelopes in Pulmonary Hypertension due to Heart Failure
Yasuyuki Chiba; Hiroyuki Iwano; Michito Murayama; Sanae Kaga; Ko Motoi; Suguru Ishizaka; Shingo Tsujinaga; Asuka Tanemura; Shinobu Yokoyama; Masahiro Nakabachi; Hisao Nishino; Kazunori Okada; Kiwamu Kamiya; Toshiyuki Nagai; Toshihisa Anzai
Journal of the American Society of Echocardiography, Elsevier BV, Dec. 2020
Scientific journal

三次元スペックルトラッキング法による右室機能解析に関する初期検討
岡田一範; 加賀早苗; 上田龍一郎; 柳裕介; 相庭美穂; 政氏伸夫; 三神大世; 中鉢雅大; 岩野弘幸; 安斉俊久
超音波医学, 47, Suppl., S221, S221, (公社)日本超音波医学会, Nov. 2020
Japanese

肺静脈血流速度波形を用いたリザーバ期の左房硬さの非侵襲的評価法の検討
阿部剛大; 岡田一範; 加賀早苗; 政氏伸夫; 三神大世; 村山迪史; 中鉢雅大; 辻永真吾; 岩野弘幸; 安斉俊久
超音波医学, 47, Suppl., S246, S246, (公社)日本超音波医学会, Nov. 2020
Japanese

房室弁開放時相差の視覚的評価に基づいたスコアリングによる左室充満圧推定と予後予測
村山迪史; 岩野弘幸; 辻永真吾; 西野久雄; 中鉢雅大; 横山しのぶ; 西田睦; 渋谷斉; 加賀早苗; 安斉俊久
超音波医学, 47, Suppl., S165, S165, (公社)日本超音波医学会, Nov. 2020
Japanese

収縮期の右房容量負荷が三尖弁輪収縮期移動距離と右室駆出率との関係に及ぼす影響
村山迪史; 加賀早苗; 岡田一範; 三神大世; 中鉢雅大; 横山しのぶ; 西野久雄; 西田睦; 岩野弘幸; 安斉俊久
超音波医学, 47, Suppl., S222, S222, (公社)日本超音波医学会, Nov. 2020
Japanese

Heart Failure With Preserved Ejection Fraction vs. Reduced Ejection Fraction ― Mechanisms of Ventilatory Inefficiency During Exercise in Heart Failure ―
Shingo Tsujinaga; Hiroyuki Iwano; Yasuyuki Chiba; Suguru Ishizaka; Miwa Sarashina; Michito Murayama; Masahiro Nakabachi; Hisao Nishino; Shinobu Yokoyama; Kazunori Okada; Sanae Kaga; Toshihisa Anzai
Circulation Reports, 2, 5, 271, 279, Japanese Circulation Society, 08 May 2020, [Peer-reviewed]
Scientific journal

収縮期の右房容量負荷が三尖弁輪収縮期移動距離に及ぼす影響
村山迪史; 加賀早苗; 岡田一範; 三神大世; 中鉢雅大; 横山しのぶ; 西野久雄; 西田睦; 澁谷斉; 辻永真吾; 岩野弘幸; 安斉俊久
超音波検査技術, 45, 2, 217, 217, (一社)日本超音波検査学会, Apr. 2020
Japanese

Significance and prognostic impact of v wave on pulmonary artery pressure in patients with heart failure: beyond the wedge pressure.
Hiroyuki Iwano; Shinobu Yokoyama; Kiwamu Kamiya; Toshiyuki Nagai; Shingo Tsujinaga; Miwa Sarashina; Suguru Ishizaka; Yasuyuki Chiba; Masahiro Nakabachi; Hisao Nishino; Michito Murayama; Kazunori Okada; Sanae Kaga; Toshihisa Anzai
Heart and vessels, 11 Mar. 2020, [Peer-reviewed], [Domestic magazines]
English, BACKGROUND: A v wave on pulmonary artery wedge (PAW) pressure sometimes augments and appears on pulmonary artery (PA) pressure wave in patients with heart failure (HF). However, the significance of PA v wave in HF remains to be elucidated. METHODS: We retrospectively analyzed pressure waveforms in 61 HF patients (left ventricular ejection fraction 35 ± 15%). On the PAW and PA pressure waveforms, mean pressure as well as peak and amplitude of v waves (ampPAWv and ampPAv, respectively) were measured. Occurrence of worsening HF and cardiac death was recorded for 2 years after the catheterization. RESULTS: The ampPAWv did not correlate with ampPAv. When the patients were divided into 4 groups: I (high-ampPAWv/high-ampPAv), II (high-ampPAWv/low-ampPAv), III (low-ampPAWv/high-ampPAv), and IV (low-ampPAWv/low-ampPAv), the prevalence of group III was low (I: 13, II: 17, III: 4, IV: 27). Mean pressures of PAW and PA were similarly elevated in groups I and II. Cardiac index was lowest (I: 2.0 ± 0.4, II: 2.8 ± 0.6, III: 2.2 ± 0.2, IV: 2.4 ± 0.6 L/min/m2, ANOVA P < 0.01, P < 0.01 for I vs II) and tricuspid annular plane systolic excursion / systolic PA pressure was impaired (I: 0.27 ± 0.07, II: 0.48 ± 0.22, III: 0.59 ± 0.35, IV: 0.68 ± 0.35 mm/mmHg, ANOVA P < 0.01) in group I. During the follow-up, 13 events were observed. Kaplan-Meier analysis showed that patients in group I were at highest risk of cardiac events. CONCLUSIONS: PA v was observed mainly in patients with augmented PAW v wave and decreased cardiac index, suggesting an advanced stage of HF. Moreover, augmented PAv was associated with worse outcome in HF patients.

Dual Gate Doppler法による左房収縮時の血流時相解析
岡田一範; 岡田由佳; 加賀早苗; 村山迪史; 中鉢雅大; 横山しのぶ; 西野久雄; 三神大世; 更科美羽; 辻永真吾; 岩野弘幸; 安斉俊久
超音波検査技術抄録集, 45, S110, S110, 一般社団法人日本超音波検査学会, 2020
Japanese

呼吸筋力評価のための横隔膜筋厚計測における適切な手技と体位
岡田一範; 神谷明子; 加賀早苗; 柳裕介; 相庭美穂; 藤澤亮介; 村山迪史; 岡田由佳; 政氏伸夫; 三神大世
超音波検査技術抄録集, 45, S212, S212, 一般社団法人日本超音波検査学会, 2020
Japanese

Left ventricular global longitudinal strain calculated from manually traced endocardial border lengths utilizing the images for routine ejection fraction measurement by biplane method of disks.
Kazunori Okada; Sanae Kaga; Minami Araki; Kosuke Tsujita; Ayaka Yoshikawa; Mizuki Hara; Yoichi Sakamoto; Nobuo Masauzi; Taisei Mikami
Journal of medical ultrasonics (2001), 47, 1, 91, 96, Jan. 2020, [Domestic magazines]
English, Scientific journal, PURPOSE: The purpose of this study was to test whether the fractional change in the endocardial border length between end-diastole and end-systole as manually traced in left ventricular ejection fraction (LVEF) measurement using the biplane method of disks (MOD) was consistent with the global longitudinal strain derived from speckle-tracking echocardiography. METHODS: For 105 patients who underwent echocardiography, two- and four-chamber images with manually traced endocardial lines for LVEF measurement by MOD were stored. LV endocardial lengths at end-diastole and at end-systole were measured on both images to calculate the fractional length changes, which were averaged (GLSMOD). Speckle-tracking analysis was performed to measure global longitudinal strains in the apical two- and four-chamber and long-axis images, and the three values were averaged (GLSSTE) according to the ASE and EACVI guidelines. RESULTS: There was no significant difference between GLSMOD and GLSSTE. GLSMOD correlated well with GLSSTE (r = 0.81, p < 0.001), and there was no fixed bias in the Bland-Altman analysis. The intraclass correlations for the intra- and inter-observer comparisons for GLSSTE were excellent, and those for GLSMOD were adequate. CONCLUSION: The fractional LV endocardial border length change, GLSMOD, showed sufficient agreement with GLSSTE to justify its use as a substitute for the STE-derived global longitudinal strain.

心エコー法とMRIによる肺動脈弁逆流重症度に乖離を認めた総動脈幹症の術後症例
岩野弘幸; 村山迪史; 山澤弘州; 武田充人; 真鍋徳子; 石森直樹; 千葉泰之; 石坂傑; 更科美羽; 辻永真吾; 中鉢雅大; 加賀早苗; 安斉俊久
日本成人先天性心疾患学会雑誌, 9, 1, 288, 288, 日本成人先天性心疾患学会, Jan. 2020, [Peer-reviewed]
Japanese

Impact of Left Ventricular Suction During Exercise on Clinical Outcomes in Patients With Heart Failure
Shingo Tsujinaga; Hiroyuki Iwano; Suguru Ishizaka; Yasuyuki Chiba; Miwa Sarashina; Michito Murayama; Masahiro Nakabachi; Shinobu Yokoyama; Hisao Nishino; Kazunori Okada; Sanae Kaga; Takuma Sato; Toshihisa Anzai
CIRCULATION, 140, Nov. 2019, [Peer-reviewed]
English

Simple and noninvasive method to estimate right ventricular operating stiffness based on echocardiographic pulmonary regurgitant velocity and tricuspid annular plane movement measurements during atrial contraction.
Michito Murayama; Kazunori Okada; Sanae Kaga; Hiroyuki Iwano; Shingo Tsujinaga; Miwa Sarashina; Masahiro Nakabachi; Shinobu Yokoyama; Hisao Nishino; Mutsumi Nishida; Hitoshi Shibuya; Nobuo Masauzi; Toshihisa Anzai; Taisei Mikami
The international journal of cardiovascular imaging, 35, 10, 1871, 1880, Oct. 2019, [Peer-reviewed], [International Magazine]
English, It was recently shown that invasively determined right ventricular (RV) stiffness was more closely related to the prognosis of patients with pulmonary hypertension than RV systolic function. So far, a completely noninvasive method to access RV stiffness has not been reported. We aimed to clarify the clinical usefulness of our new echocardiographic index of RV operating stiffness using atrial-systolic descent of the pulmonary artery-RV pressure gradient derived from pulmonary regurgitant velocity (PRPGDAC) and tricuspid annular plane movement during atrial contraction (TAPMAC). We studied 81 consecutive patients with various cardiac diseases who underwent echocardiography and cardiac catheterization. We measured PRPGDAC and TAPMAC using continuous-wave Doppler and M-mode echocardiography, respectively, and calculated PRPGDAC/TAPMAC. RV end-diastolic pressure (RVEDP) and RV pressure increase during atrial contraction (ΔRVPAC) were invasively measured, and RV volume change during atrial contraction (ΔVAC) was calculated from echocardiographic late-diastolic transtricuspid flow time-velocity integral and tricuspid annular area; thus ΔRVPAC/ΔVAC was used as the standard index for RV operating stiffness. PRPGDAC/TAPMAC well correlated with ΔRVPAC/ΔVAC (r = 0.84, p < 0.001) and RVEDP (r = 0.80, p < 0.001), and the area under the receiver operating characteristic curve to discriminate RVEDP > 12 mmHg was 0.94. Multivariate regression analysis revealed that PRPGDAC/TAPMAC was the single independent determinant of ΔRVPAC/ΔVAC (β = 0.86, p < 0.001). PRPGDAC/TAPMAC is useful to estimate RV operating stiffness and a good practical indicator of RVEDP.

これからの超音波検査を牽引する人材の育成を目指す大学院教育
岡田一範; 加賀早苗; 政氏伸夫; 三神大世; 中鉢雅大; 村山迪史; 横山しのぶ; 西野久雄; 西田睦; 澁谷斉; 更科美羽; 辻永真吾; 岩野弘幸; 安斉俊久
臨床検査学教育, 11, 2, 219, 226, (一社)日本臨床検査学教育協議会, Sep. 2019
Japanese

心不全における肺動脈圧波形上のv波出現の意義に関する検討
岩野弘幸; 横山しのぶ; 石坂傑; 千葉泰之; 更科美羽; 辻永真吾; 中鉢雅大; 加賀早苗; 神谷究; 永井利幸; 安斉俊久
日本心臓病学会学術集会抄録, 67回, O, 281, (一社)日本心臓病学会, Sep. 2019
Japanese

Tricuspid regurgitation occurring in the early-diastolic phase in a case of heart failure: Insights from echocardiographic and invasive hemodynamic findings.
Michito Murayama; Hiroyuki Iwano; Shingo Tsujinaga; Miwa Sarashina; Suguru Ishizaka; Yasuyuki Chiba; Masahiro Nakabachi; Shinobu Yokoyama; Hisao Nishino; Kazunori Okada; Sanae Kaga; Hitoshi Shibuya; Mutsumi Nishida; Toshihisa Anzai
Echocardiography (Mount Kisco, N.Y.), 36, 9, 1771, 1775, Sep. 2019, [Peer-reviewed], [International Magazine]
English, Although the presence and physiological significance of late-diastolic tricuspid regurgitation (TR) have been reported, those in TR occurring in early diastole have not been well known. We herein first presented a case of heart failure due to dilated cardiomyopathy showing functional TR occurring in the early-diastolic phase in whom the mechanism for its genesis could be precisely assessed from echocardiographic findings and intra-cardiac pressure recordings.

Clinical significance of end-diastolic opening of pulmonary valve in a case complicating left ventricular systolic dysfunction.
Nishino H; Iwano H; Kaga S; Nishida M; Akizawa K; Teshima T; Anzai T
Journal of echocardiography, 19, 1, 53, 55, Aug. 2019, [Peer-reviewed], [Domestic magazines]
English, Scientific journal

Right ventricular basal inflow and outflow tract diameters overestimate right ventricular size in subjects with sigmoid-shaped interventricular septum: a study using three-dimensional echocardiography
Okada K; Kaga S; Tsujita K; Sakamoto Y; Masauzi N; Mikami T
Int J Cardiovasc Imaging, 35, 7, 1211, 1219, Jul. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, Sigmoid-shaped ventricular septum (SS), a frequently encountered minor abnormality in echocardiographic examinations of the elderly, may have some influence on RV shape. We aimed to determine the influence of SS on the accuracy of the 6 RV linear diameter measurements in the light of three-dimensional echocardiographic (3DE) RV volume. The aorto-septal angle (ASA) was measured in the parasternal long-axis view using two-dimensional echocardiography (2DE) as an index of SS in 70 patients without major cardiac abnormalities who were subdivided into 35 with SS (ASA ≤ 120°) and 35 without SS (NSS). We measured RV end-diastolic volume (RVEDV) using 3DE; in addition, using 2DE, we measured basal RV diameter, mid-cavity diameter, longitudinal diameter and end-diastolic area in the apical four-chamber view; proximal RV outflow tract (RVOT) diameter in the parasternal long-axis view; and proximal and distal RVOT diameters in the parasternal short-axis view. RVEDV did not differ between the SS and NSS groups. The SS group had greater basal RV diameter and proximal and distal RVOT diameters than the NSS group. RV mid-cavity diameter, longitudinal diameter, and end-diastolic area did not differ between the groups. Among the 2DE parameters of RV size, RV end-diastolic area was most strongly correlated with RVEDV (r = 0.67), followed by RV mid-cavity diameter (r = 0.58). When SS is present, the echocardiographic basal RV diameter and RVOT diameters overestimate RV size, and the measurement of RV end-diastolic area and mid-cavity diameter more correctly reflect 3D RV volume.

Diastolic Intra-Left Ventricular Pressure Difference During Exercise: Strong Determinant and Predictor of Exercise Capacity in Patients With Heart Failure.
Shingo Tsujinaga; Hiroyuki Iwano; Miwa Sarashina; Taichi Hayashi; Michito Murayama; Ayako Ichikawa; Masahiro Nakabachi; Hisao Nishino; Shinobu Yokoyama; Arata Fukushima; Takashi Yokota; Kazunori Okada; Sanae Kaga; Pavlos P Vlachos; Toshihisa Anzai
Journal of cardiac failure, 25, 4, 268, 277, Apr. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: Although the enhancement of early-diastolic intra-left ventricular pressure difference (IVPD) during exercise is considered to maintain exercise capacity, little is known about their relationship in heart failure (HF). METHODS AND RESULTS: Cardiopulmonary exercise testing and exercise-stress echocardiography were performed in 50 HF patients (left ventricular [LV] ejection fraction 39 ± 15%). Echocardiographic images were obtained at rest and submaximal and peak exercise. Color M-mode Doppler images of LV inflow were used to determine IVPD. Thirty-five patients had preserved exercise capacity (peak oxygen consumption [VO2] ≥14 mL·kg-1·min-1; group 1) and 15 patients had reduced exercise capacity (group 2). During exercise, IVPD increased only in group 1 (group 1: 1.9 ± 0.9 mm Hg at rest, 4.1 ± 2.0 mm Hg at submaximum, 4.7 ± 2.1 mm Hg at peak; group 2: 1.9 ± 0.8 mm Hg at rest, 2.1 ± 0.9 mm Hg at submaximum, 2.1 ± 0.9 mm Hg at peak). Submaximal IVPD (r = 0.54) and peak IVPD (r = 0.69) were significantly correlated with peak VO2. Peak IVPD determined peak VO2 independently of LV ejection fraction. Moreover, submaximal IVPD could well predict the reduced exercise capacity. CONCLUSION: Early-diastolic IVPD during exercise was closely associated with exercise capacity in HF. In addition, submaximal IVPD could be a useful predictor of exercise capacity without peak exercise in HF patients.

心不全患者における運動中の換気効率のメカニズム駆出率の保たれた心不全と駆出率が低下した心不全の比較(Mechanisms of Ventilatory Efficiency during Exercise in Heart Failure: Comparison between Heart Failure with Preserved Ejection Fraction and Reduced Ejection Fraction)
辻永真吾; 岩野弘幸; 更科美羽; 村山迪史; 中鉢雅大; 横山しのぶ; 西野久雄; 岡田一範; 加賀早苗; 福島新; 横田卓; 安斉俊久
日本循環器学会学術集会抄録集, 83回, OJ08, 2, (一社)日本循環器学会, Mar. 2019
English

心不全患者における左室動作時スティフネスに関する新規心エコー指標の予後に対する価値(Prognostic Value of Novel Echocardiographic Index of Left Ventricular Operating Stiffness in Patients with Heart Failure)
岡田一範; 藤澤亮介; 加賀早苗; 政氏伸夫; 三神大世; 村山迪史; 中鉢雅大; 西野久雄; 横山しのぶ; 更科美羽; 辻永真吾; 岩野弘幸; 安斉俊久
日本循環器学会学術集会抄録集, 83回, OJ08, 7, (一社)日本循環器学会, Mar. 2019
English

Novel echocardiographic method to assess left ventricular chamber stiffness and elevated end-diastolic pressure based on time-velocity integral measurements of pulmonary venous and transmitral flows.
Kazunori Okada; Sanae Kaga; Rika Abiko; Michito Murayama; Takuma Hioka; Masahiro Nakabachi; Shinobu Yokoyama; Hisao Nishino; Ayako Ichikawa; Ayumu Abe; Mutsumi Nishida; Naoya Asakawa; Shingo Tsujinaga; Taichi Hayashi; Hiroyuki Iwano; Satoshi Yamada; Nobuo Masauzi; Taisei Mikami
European heart journal cardiovascular Imaging, 19, 11, 1260, 1267, 01 Nov. 2018, [Peer-reviewed], [International Magazine]
English, Scientific journal, Aims: The detection of increased left ventricular (LV) chamber stiffness may play an important role in assessing cardiac patients with potential but not overt heart failure. A non-invasive method to estimate it is not established. We investigated whether the echocardiographic backward/forward flow volume ratio from the left atrium (LA) during atrial contraction reflects the LV chamber stiffness. Methods and results: We studied 62 patients who underwent cardiac catheterization and measured their left ventricular end-diastolic pressure (LVEDP) and pressure increase during atrial contraction (ΔPa) from the LV pressure waveform. Using the echocardiographic biplane method of disks, we measured the LV volume change during atrial contraction indexed to the body surface area (ΔVa), and ΔPa/ΔVa was calculated as a standard for the LV operating chamber stiffness. Using pulsed Doppler echocardiography, we measured the time-velocity integral (TVI) of the backward pulmonary venous (PV) flow during atrial contraction (IPVA) and the ratio of IPVA to the PV flow TVI throughout a cardiac cycle (FPVA). We also measured the TVI of the atrial systolic forward transmitral flow (IA) and the ratio of the IA to the transmitral TVI during a cardiac cycle (FA) and calculated IPVA/IA and FPVA/FA. IPVA/IA and FPVA/FA were well correlated with ΔPa/ΔVa (r = 0.79 and r = 0.81) and LVEDP (r = 0.73 and r = 0.77). The areas under the ROC curve to discriminate LVEDP >18 mmHg were 0.90 for IPVA/IA and 0.93 for FPVA/FA. Conclusion: The FPVA/FA, the backward/forward flow volume ratio from the LA during atrial contraction, is useful for non-invasive assessments of LV chamber stiffness and elevated LVEDP.

Correction to: Altered oscillation of Doppler-derived renal and renal interlobar venous flow velocities in hypertensive and diabetic patients.
Kudo Y; Mikami T; Nishida M; Okada K; Kaga S; Masauzi N; Omotehara S; Shibuya H; Kahata K; Shimizu C
Journal of medical ultrasonics (2001), 45, 1, 197, 197, Jan. 2018, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, In the original publication of this paper the legend of Fig. 1 should read as: Fig. 1 Pulsed Doppler flow velocity recordings of the aorta (a), right renal artery (b), right renal interlobar artery (c), inferior vena cava (d), right renal vein (e), and right renal interlobar vein (f). PSV peak systolic velocity, EDV end-diastolic velocity, V MAX maximum velocity, V MIN minimum velocity.

Quantitative distinction of morphological characteristics of white blood cells in peripheral blood through texture analysis using gray level co-occurrence matrix
Yamamoto M; Kono K; Kuroki M; Murakami S; Hayata R; Nanato K; Shao M; Miwa K; Tsutsumi Y; Okada K; Kaga S; Masauzi N
Clin Lab, 63, 11, 1851, 1868, Nov. 2017, [Peer-reviewed]
English, Scientific journal

Altered oscillation of Doppler-derived renal and renal interlobar venous flow velocities in hypertensive and diabetic patients
Yusuke Kudo; Taisei Mikami; Mutsumi Nishida; Kazunori Okada; Sanae Kaga; Nobuo Masauzi; Satomi Omotehara; Hitoshi Shibuya; Kaoru Kahata; Chikara Shimizu
JOURNAL OF MEDICAL ULTRASONICS, 44, 4, 305, 314, Oct. 2017, [Peer-reviewed]
English, Scientific journal

Overestimation by echocardiography of the peak systolic pressure gradient between the right ventricle and right atrium due to tricuspid regurgitation and the usefulness of the early diastolic transpulmonary valve pressure gradient for estimating pulmonary artery pressure
Takuma Hioka; Sanae Kaga; Taisei Mikami; Kazunori Okada; Michito Murayama; Nobuo Masauzi; Masahiro Nakabachi; Hisao Nishino; Shinobu Yokoyama; Mutsumi Nishida; Hiroyuki Iwano; Mamoru Sakakibara; Satoshi Yamada; Hiroyuki Tsutsui
HEART AND VESSELS, 32, 7, 833, 842, Jul. 2017, [Peer-reviewed]
English, Scientific journal

Relationships of left ventricular strain and strain rate to wall stress and their afterload dependency
Daisuke Murai; Satoshi Yamada; Taichi Hayashi; Kazunori Okada; Hisao Nishino; Masahiro Nakabachi; Shinobu Yokoyama; Ayumu Abe; Ayako Ichikawa; Kota Ono; Sanae Kaga; Hiroyuki Iwano; Taisei Mikami; Hiroyuki Tsutsui
HEART AND VESSELS, 32, 5, 574, 583, May 2017, [Peer-reviewed]
English, Scientific journal

Characteristic systolic waveform of left ventricular longitudinal strain rate in patients with hypertrophic cardiomyopathy
Kazunori Okada; Sanae Kaga; Taisei Mikami; Nobuo Masauzi; Ayumu Abe; Masahiro Nakabachi; Shinobu Yokoyama; Hisao Nishino; Ayako Ichikawa; Mutsumi Nishida; Daisuke Murai; Taichi Hayashi; Chikara Shimizu; Hiroyuki Iwano; Satoshi Yamada; Hiroyuki Tsutsui
HEART AND VESSELS, 32, 5, 591, 599, May 2017, [Peer-reviewed]
English, Scientific journal

USEFULNESS OF THE CONTINUOUS-WAVE DOPPLER-DERIVED PULMONARY ARTERIAL-RIGHT VENTRICULAR PRESSURE GRADIENT JUST BEFORE ATRIAL CONTRACTION FOR THE ESTIMATION OF PULMONARY ARTERIAL DIASTOLIC AND WEDGE PRESSURES
Michito Murayama; Taisei Mikami; Sanae Kaga; Kazunori Okada; Takuma Hioka; Nobuo Masauzi; Masahiro Nakabachi; Hisao Nishino; Shinobu Yokoyama; Mutsumi Nishida; Hiroyuki Iwano; Mamoru Sakakibara; Satoshi Yamada; Hiroyuki Tsutsui
ULTRASOUND IN MEDICINE AND BIOLOGY, 43, 5, 958, 966, May 2017, [Peer-reviewed]
English, Scientific journal

Quantitative distinction of the morphological characteristic of erythrocyte precursor cells with texture analysis using gray level co-occurrence matrix
Kono K; Hayata R; Murakami S; Yamamoto M; Kuroki M; Nanato K; Takahashi K; Miwa K; Okada K; Kaga S; Mikami T; Masauzi N
J Clin Lab Anal, 32, 1, Feb. 2017, [Peer-reviewed]
English, Scientific journal

Semi-Automatic Rating Method for Neutrophil Alkaline Phosphatase Activity
Kanae Sugano; Kotomi Hashi; Misaki Goto; Kiyotaka Nishi; Rie Maeda; Keigo Kono; Mai Yamamoto; Kazunori Okada; Sanae Kaga; Keiko Miwa; Taisei Mikami; Nobuo Masauzi
JOURNAL OF CLINICAL LABORATORY ANALYSIS, 31, 1, Jan. 2017, [Peer-reviewed]
English, Scientific journal

A new method to estimate pulmonary vascular resistance using diastolic pulmonary artery-right ventricular pressure gradients derived from continuous-wave Doppler velocity measurements of pulmonary regurgitation
Sanae Kaga; Taisei Mikami; Michito Murayama; Kazunori Okada; Nobuo Masauzi; Masahiro Nakabachi; Hisao Nishino; Shinobu Yokoyama; Mutsumi Nishida; Taichi Hayashi; Daisuke Murai; Hiroyuki Iwano; Mamoru Sakakibara; Satoshi Yamada; Hiroyuki Tsutsui
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING, 33, 1, 31, 38, Jan. 2017, [Peer-reviewed]
English, Scientific journal

Additive Predictive Value of Strain Rate Dispersion Index for Responses to Cardiac Resynchronization Therapy: Substudy From the START Study
Iwano Hiroyuki; Yamada Satoshi; Okada Kazunori; Hayashi Taichi; Tsujinaga Shingo; Yokoyama Shinobu; Nakabachi Masahiro; Nishino Hisao; Ichikawa Ayako; Abe Ayumu; Kaga Sanae; Mikami Taisei; Tsutsui Hiroyuki
CIRCULATION, 134, 11 Nov. 2016, [Peer-reviewed]

Semiautomated Segmentation and Measurement of Cytoplasmic Vacuoles in a Neutrophil With General-Purpose Image Analysis Software
Maki Mizukami; Misaki Yamada; Sayaka Fukui; Nao Fujimoto; Shigeru Yoshida; Sanae Kaga; Keiko Obata; Shigeki Jin; Keiko Miwa; Nobuo Masauzi
JOURNAL OF CLINICAL LABORATORY ANALYSIS, 30, 6, 918, 923, Nov. 2016, [Peer-reviewed]
English, Scientific journal

Long-term echocardiographic evaluation of valvular lesions in a patients with nonbacterial thrombotic endocarditis associated with advanced uterine cancer
Yokoyama S; Iwano H; Yamada S; Takeda M; Kaga S; Nakabachi M; Nishino H; Ichikawa A; Abe A; Okada K; Murai D; Hayashi T; Nishida M; Shibuya H; Kahata K; Shimizu C; Mikami T; Tsutsui H
J Cardiol Cases, 14, 3, 82, 86, Sep. 2016, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, Nonbacterial thrombotic endocarditis (NBTE) is characterized by the deposition of thrombi on previously undamaged heart valves in the absence of bacteremia and predominantly affects patients with hypercoagulable state. Although the diagnosis is usually based on transthoracic echocardiography, little is known about the serial changes of the vegetation in response to treatment. We experienced a 42-year-old woman with advanced uterine cancer and asymptomatic cerebral embolization. Plasma d-dimer level was markedly elevated and echocardiography showed highly mobile masses attached to the anterior and posterior mitral leaflets with moderate regurgitation. Based on these findings, she was diagnosed as having NBTE associated with uterine cancer and intravenous administration of heparin and chemotherapy were performed. Follow-up echocardiography revealed the disappearance of the vegetation and reduction of mitral regurgitation. Uterine cancer was successfully treated by surgery and recurrence of the valvular lesion did not occur. .

心エコー法による肺高血圧症の診断と病型分類
喜田真由子; 加賀早苗; 岡田一範; 村山迪史; 阿部歩; 市川絢子; 中鉢雅大; 西野久雄; 横山しのぶ; 西田睦; 山田聡; 三神大世
超音波検査技術, 41, 3, 314, 314, (一社)日本超音波検査学会, Jun. 2016
Japanese

肺動脈拡張期圧の推定は心房収縮の前後いずれで行うべきか?
村山迪史; 加賀早苗; 岡田一範; 樋岡拓馬; 阿部歩; 市川絢子; 中鉢雅大; 西野久雄; 横山しのぶ; 西田睦; 山田聡; 三神大世
超音波検査技術, 41, 3, 314, 314, (一社)日本超音波検査学会, Jun. 2016
Japanese

SONOGRAPHIC DETECTION OF ABNORMAL PLAQUE MOTION OF THE CAROTID ARTERY: ITS USEFULNESS IN DIAGNOSING HIGH-RISK LESIONS RANGING FROM PLAQUE RUPTURE TO ULCER FORMATION
Mutsuko Muraki; Taisei Mikami; Tetsuyuki Yoshimoto; Shin Fujimoto; Zmayumi Kitaguchi; Sanae Kaga; Tomoko Sugawara; Kouichi Tokuda; Sadao Kaneko; Takeshi Kashiwaba
ULTRASOUND IN MEDICINE AND BIOLOGY, 42, 2, 358, 364, Feb. 2016, [Peer-reviewed]
English, Scientific journal

Myocardial Shortening in 3 Orthogonal Directions and Its Transmural Variation in Patients With Nonobstructive Hypertrophic Cardiomyopathy
Kazunori Okada; Satoshi Yamada; Hiroyuki Iwano; Hisao Nishino; Masahiro Nakabachi; Shinobu Yokoyama; Ayumu Abe; Ayako Ichikawa; Sanae Kaga; Mutsumi Nishida; Taichi Hayashi; Daisuke Murai; Taisei Mikami; Hiroyuki Tsutsui
CIRCULATION JOURNAL, 79, 11, 2471, 2479, Nov. 2015, [Peer-reviewed]
English, Scientific journal

Quantitative and Pattern Analyses of Continuous-Wave Doppler-Derived Pulmonary Regurgitant Flow Velocity for the Diagnosis of Constrictive Pericarditis
Sanae Kaga; Taisei Mikami; Yuka Takamatsu; Ayumu Abe; Kazunori Okada; Masahiro Nakabachi; Hisao Nishino; Shinobu Yokoyama; Mutsumi Nishida; Chikara Shimizu; Hiroyuki Iwano; Satoshi Yamada; Hiroyuki Tsutsui
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, 27, 11, 1223, 1229, Nov. 2014, [Peer-reviewed]
English, Scientific journal

Decreased Aorto-septal Angle May Contribute to Left Ventricular Diastolic Dysfunction in Healthy Subjects
Kazunori Okada; Taisei Mikami; Sanae Kaga; Masahiro Nakabachi; Ayumu Abe; Shinobu Yokoyama; Hisao Nishino; Mutsumi Nishida; Chikara Shimizu; Hiroyuki Iwano; Satoshi Yamada; Hiroyuki Tsutsui
JOURNAL OF CLINICAL ULTRASOUND, 42, 6, 341, 347, Jul. 2014, [Peer-reviewed]
English, Scientific journal

超音波診断!その時あなたはどう考える? エキスパートのバーチャルルーチン検査に迫る!! 膵疾患に迫る!!
西田睦; 佐藤恵美; 工藤悠輔; 井上真美子; 表原里実; 堀江達則; 和田妙子; 岩井孝仁; 石坂欣也; 加賀早苗
超音波検査技術, 38, Suppl., S75, S76, (一社)日本超音波検査学会, Jun. 2013
Japanese

Coexisting cardiac diseases and pressure recovery phenomenon contribute to discrepancy between the echocardiographic severity of aortic stenosis and left ventricular hypertrophy
Ayumu Abe; Taisei Mikami; Sanae Kaga; Kanako Tsuji; Kazunori Okada; Shinobu Yokoyama; Hisao Nishino; Masahiro Nakabachi; Mutsumi Nishida; Chikara Shimizu; Hiroyuki Iwano; Satoshi Yamada; Hiroyuki Tsutsui
Journal of Echocardiography, 11, 2, 41, 49, Jun. 2013, [Peer-reviewed]
English, Scientific journal

Coexisting cardiac diseases and pressure recovery phenomenon contribute to discrepancy between the echocardiographic severity of aortic stenosis and left ventricular hypertrophy
Ayumu Abe; Taisei Mikami; Sanae Kaga; Kanako Tsuji; Kazunori Okada; Shinobu Yokoyama; Hisao Nishino; Masahiro Nakabachi; Mutsumi Nishida; Chikara Shimizu; Hiroyuki Iwano; Satoshi Yamada; Hiroyuki Tsutsui
Journal of Echocardiography, 11, 2, 41, 49, Jun. 2013, [Peer-reviewed]
English, Scientific journal

Strain rate dispersion index can predict changes in left ventricular volume and adverse cardiac events following cardiac resynchronization therapy
Hiroyuki Iwano; Satoshi Yamada; Masaya Watanabe; Hirofumi Mitsuyama; Kazuya Mizukami; Hisao Nishino; Shinobu Yokoyama; Sanae Kaga; Kazunori Okada; Mutsumi Nishida; Hisashi Yokoshiki; Taisei Mikami; Hiroyuki Tsutsui
Circulation Journal, 77, 11, 2757, 2765, 2013, [Peer-reviewed]
English, Scientific journal

Overweight causes left ventricular diastolic asynchrony and diastolic dysfunction: A study based on speckle tracking echocardiography in healthy subjects
Masahiro Nakabachi; Taisei Mikami; Kazunori Okada; Hisao Onozuka; Sanae Kaga; Mamiko Inoue; Shinobu Yokoyama; Mutsumi Nishida; Chikara Shimizu; Kazuhiko Matsuno; Hiroyuki Iwano; Satoshi Yamada; Hiroyuki Tsutsui
Journal of Echocardiography, 10, 3, 83, 89, Sep. 2012, [Peer-reviewed], [Domestic magazines]
English, Scientific journal

Early diastolic mitral annular velocity at the interventricular septal annulus correctly reflects left ventricular longitudinal myocardial relaxation
Kazunori Okada; Taisei Mikami; Sanae Kaga; Hisao Onozuka; Mamiko Inoue; Shinobu Yokoyama; Hisao Nishino; Mutsumi Nishida; Kazuhiko Matsuno; Hiroyuki Iwano; Satoshi Yamada; Hiroyuki Tsutsui
EUROPEAN JOURNAL OF ECHOCARDIOGRAPHY, 12, 12, 917, 923, Dec. 2011, [Peer-reviewed]
English, Scientific journal

Novel Strain Rate Index of Contractility Loss Caused by Mechanical Dyssynchrony - A Predictor of Response to Cardiac Resynchronization Therapy -
Hiroyuki Iwano; Satoshi Yamada; Masaya Watanabe; Hirofumi Mitsuyama; Hisao Nishino; Shinobu Yokoyama; Sanae Kaga; Mutsumi Nishida; Hisashi Yokoshiki; Hisao Onozuka; Taisei Mikami; Hiroyuki Tsutsui
CIRCULATION JOURNAL, 75, 9, 2167, 2175, Sep. 2011, [Peer-reviewed]
English, Scientific journal

造影超音波検査はIgG4関連硬化性胆管炎と胆管癌の鑑別に有用か
西田睦; 佐藤恵美; 工藤悠輔; 井上真美子; 表原里実; 堀江達則; 加賀早苗; 河上洋; 清水力; 松野一彦
超音波医学, 38, Suppl., S410, S410, (公社)日本超音波医学会, Apr. 2011
Japanese

上腕駆血によるFMD検査の再現性の検討
井上真美子; 西田睦; 吉永恵一郎; 佐藤恵美; 石坂香織; 工藤悠輔; 表原里実; 堀江達則; 加賀早苗; 横山しのぶ; 西野久雄; 鈴木春樹; 清水力; 松野一彦
超音波医学, 38, 2, 160, 161, (公社)日本超音波医学会, Mar. 2011
Japanese

僧帽弁輪石灰化により拡張早期僧帽弁輪運動速度が低下する機序
柿本悠太; 三神大世; 岡田一範; 小野塚久夫; 加賀早苗; 西田睦; 松野一彦; 岩野弘幸; 山田聡; 筒井裕之
超音波医学, 38, 2, 161, 162, (公社)日本超音波医学会, Mar. 2011
Japanese

左室収縮障害患者における左室後壁屈曲の機序とその意義
三谷麻子; 三神大世; 岩井孝仁; 小野塚久夫; 加賀早苗; 西田睦; 松野一彦; 岩野弘幸; 山田聡; 筒井裕之
超音波医学, 38, 2, 162, 162, (公社)日本超音波医学会, Mar. 2011
Japanese

乳腺腫瘍の良・悪性鑑別におけるstrain ratioの有用性
工藤悠輔; 西田睦; 石坂香織; 佐藤恵美; 井上真美子; 表原里実; 堀江達則; 加賀早苗; 横山しのぶ; 西野久雄; 細田充主; 高橋弘昌; 鈴木春樹; 清水力; 松野一彦
超音波医学, 38, 2, 162, 163, (公社)日本超音波医学会, Mar. 2011
Japanese

3Dスペックルトラッキング法による左室拡張機能評価 Area tracking rate計測の意義
加賀早苗; 小野塚久夫; 山田聡; 三神大世; 岩野弘幸; 横山しのぶ; 西野久雄; 西田睦; 清水力; 筒井裕之; 松野一彦
日本心臓病学会誌, 5, Suppl.I, 266, 266, (一社)日本心臓病学会, Aug. 2010
Japanese

Relation between myocardial blood volume and left ventricular contractile reserve in patients with dilated cardiomyopathy
YAMADA Satoshi; IWANO Hiroyuki; KOMURO Kaoru; OKADA Masako; KOMATSU Hiroshi; KAGA Sanae; NISHIDA Mutsumi; ONOZUKA Hisao; MIKAMI Taisei; TSUTSUI Hiroyuki
Choonpa Igaku, 37, 4, 491, 497, 15 Jul. 2010
Japanese

拡張早期の僧帽弁輪運動速度と左室心筋伸展との関係健常例と肥大心における検討
岡田一範; 三神大世; 加賀早苗; 小野塚久夫; 横山しのぶ; 西田睦; 松野一彦; 岩野弘幸; 山田聡; 筒井裕之
超音波医学, 37, 4, 533, 533, (公社)日本超音波医学会, Jul. 2010
Japanese

健常人における左室拡張機能障害の機序の二次元スペックルトラッキング法による分析
中鉢雅大; 三神大世; 小野塚久夫; 中村安岐; 岡田一範; 加賀早苗; 西田睦; 岩野弘幸; 山田聡; 筒井裕之
超音波医学, 37, 4, 533, 533, (公社)日本超音波医学会, Jul. 2010
Japanese

3Dグローバルストレインレートによる左室拡張機能評価
加賀早苗; 小野塚久夫; 三神大世; 佐々木洸太; 西野久雄; 横山しのぶ; 西田睦; 松野一彦; 山田聡; 筒井裕之
超音波医学, 37, 4, 533, 533, (公社)日本超音波医学会, Jul. 2010
Japanese

大動脈弁口部圧較差への圧力回復現象補正の要否についての検討
西野久雄; 三神大世; 山田聡; 佐藤陽子; 岩野弘幸; 筒井裕之; 横山しのぶ; 加賀早苗; 西田睦; 松野一彦
超音波医学, 37, 4, 534, 535, (公社)日本超音波医学会, Jul. 2010
Japanese

大動脈弁狭窄の心エコー評価に圧力回復現象の補正は必要か?
西野久雄; 三神大世; 山田聡; 佐藤陽子; 岩野弘幸; 筒井裕之; 小野塚久夫; 横山しのぶ; 加賀早苗; 西田睦; 松野一彦
超音波検査技術, 35, 2, 257, 257, (一社)日本超音波検査学会, Apr. 2010
Japanese

非協調運動による左室全体収縮能の損失分を表す新しいストレインレート指標
岩野弘幸; 山田聡; 佐藤陽子; 西野久雄; 横山しのぶ; 加賀早苗; 西田睦; 小野塚久夫; 三神大世; 筒井裕之
超音波医学, 37, Suppl., S312, S312, (公社)日本超音波医学会, Apr. 2010
Japanese

慢性心房細動患者における機能的僧帽弁逆流の機序の心エコーによる分析
小泉遥香; 三神大世; 岩井孝仁; 小野塚久夫; 岡田一範; 横山しのぶ; 加賀早苗; 井上真美子; 西田睦; 鈴木春樹; 清水力; 松野一彦; 佐藤陽子; 岩野弘幸; 山田聡; 筒井裕之
超音波医学, 37, 1, 41, 41, (公社)日本超音波医学会, Jan. 2010
Japanese

左室充満圧推定における肺動脈弁逆流血流速度計測の臨床的意義の検討
高松由佳; 小野塚久夫; 三神大世; 井上真美子; 佐々木洸太; 加賀早苗; 横山しのぶ; 表原里実; 西野久雄; 西田睦; 松野一彦; 佐藤陽子; 岩野弘幸; 山田聡; 筒井裕之
超音波医学, 37, 1, 41, 42, (公社)日本超音波医学会, Jan. 2010
Japanese

健常人における左室拡張機能障害の分析二次元スペックルトラッキング法による心筋弛緩速度とその同期性の分析に基づく検討
中村安岐; 三神大世; 中鉢雅大; 岡田一範; 加賀早苗; 井上真美子; 横山しのぶ; 表原里実; 西田睦; 松野一彦; 佐藤陽子; 岩野弘幸; 山田聡; 小野塚久夫; 筒井裕之
超音波医学, 37, 1, 43, 44, (公社)日本超音波医学会, Jan. 2010
Japanese

Angiotensin II Receptor Blocker, Valsartan, Increases Myocardial Blood Volume and Regresses Hypertrophy in Hypertensive Patients
Hiroshi Komatsu; Satoshi Yamada; Hiroyuki Iwano; Masako Okada; Hisao Onozuka; Taisei Mikami; Shinobu Yokoyama; Mamiko Inoue; Sanae Kaga; Mutsumi Nishida; Chikara Shimizu; Kazuhiko Matsuno; Hiroyuki Tsutsui
CIRCULATION JOURNAL, 73, 11, 2098, 2103, Nov. 2009, [Peer-reviewed]
English, Scientific journal

組織ドプラ法による僧帽弁輪運動速度は左室心筋伸展を正しく反映するか? 健常例と高血圧患者における検討
岡田一範; 三神大世; 小野塚久夫; 本田舞; 加賀早苗; 井上真美子; 横山しのぶ; 西田睦; 鈴木春樹; 清水力; 松野一彦; 佐藤陽子; 岩野弘幸; 山田聡; 筒井裕之
臨床病理, 57, 補冊, 150, 150, (一社)日本臨床検査医学会, Jul. 2009
Japanese

慢性心房細動患者における機能的僧帽弁逆流の機序の心エコーによる分析
岩井孝仁; 三神大世; 小野塚久夫; 小泉遥香; 岡田一範; 横山しのぶ; 加賀早苗; 井上真美子; 西田睦; 鈴木春樹; 清水力; 松野一彦; 佐藤陽子; 岩野弘幸; 山田聡; 筒井裕之
臨床病理, 57, 補冊, 150, 150, (一社)日本臨床検査医学会, Jul. 2009
Japanese

無痛性甲状腺炎の超音波像
工藤悠輔; 西田睦; 石坂香織; 佐藤恵美; 井上真美子; 加賀早苗; 横山しのぶ; 表原里美; 鈴木春樹; 清水力; 松野一彦
超音波検査技術, 34, 3, 361, 361, (一社)日本超音波検査学会, Jun. 2009
Japanese

Right ventricular diastolic dysfunction in patients with left ventricular hypertrophy: Analysis of right ventricular myocardial relaxation using two-dimensional speckle tracking imaging
Sanae Kaga; Taisei Mikami; Hisao Onozuka; Satomi Omotehara; Ayumu Abe; Satoshi Yamada; Masako Okada; Hiroshi Komatsu; Mamiko Inoue; Shinobu Yokoyama; Mutsumi Nishida; Chikara Shimizu; Kazuhiko Matsuno; Hiroyuki Tsutsui
Journal of Echocardiography, 7, 2, 25, 33, Jun. 2009, [Peer-reviewed]
English, Scientific journal

心不全のない左室肥大患者の拡張機能評価どの指標が有用か?
表原里実; 三神大世; 小野塚久夫; 加賀早苗; 井上真美子; 横山しのぶ; 西田睦; 清水力; 松野一彦; 山田聡; 筒井裕之
超音波検査技術, 34, 2, 214, 214, (一社)日本超音波検査学会, Apr. 2009
Japanese

二次元スペックルトラッキング法による短軸心筋ストレイン計測の心臓再同期療法適応判定における意義
加賀早苗; 小野塚久夫; 三神大世; 井上真美子; 横山しのぶ; 西田睦; 鈴木春樹; 清水力; 松野一彦; 岩野弘幸; 小松博史; 岡田昌子; 山田聡; 筒井裕之
超音波医学, 35, 4, 460, 460, (公社)日本超音波医学会, Jul. 2008
Japanese

CT/MRIにて確定診断に至らなかった結節に対する造影超音波(CEUS)の位置づけ
西田睦; 増田香織; 佐藤恵美; 溝口恵美; 小野寺祐也; 尾松徳彦; 神島保; 加藤扶美; 加賀早苗; 井上真美子; 横山しのぶ; 鈴木春樹; 清水力; 松野一彦; 玉木長良; 白土博樹
超音波医学, 35, 4, 463, 463, (公社)日本超音波医学会, Jul. 2008
Japanese

心房収縮期の僧帽弁輪運動速度と左室スティッフネスとの関係
吉原明日香; 三神大世; 山田聡; 小室薫; 小松博史; 岡田昌子; 井上真美子; 加賀早苗; 横山しのぶ; 西田睦; 松野一彦; 阿部歩; 小野塚久夫; 筒井裕之
超音波医学, 35, 1, 69, 69, (公社)日本超音波医学会, Jan. 2008
Japanese

左室肥大が右室全体機能に与える影響とその機序:血流ドプラ法と二次元スペックルトラッキング法による検討
表原里実; 三神大世; 加賀早苗; 小野塚久夫; 阿部歩; 井上真美子; 横山しのぶ; 西田睦; 鈴木春樹; 清水力; 松野一彦; 小松博史; 岡田昌子; 山田聡; 筒井裕之
超音波医学, 35, 1, 69, 70, (公社)日本超音波医学会, Jan. 2008
Japanese

肥大型心筋症における左右両心室の局所心筋機能二次元スペックルトラッキング法による評価
加賀早苗; 三神大世; 小野塚久夫; 井上真美子; 横山しのぶ; 西田睦; 鈴木春樹; 清水力; 松野一彦; 小松博史; 岡田昌子; 山田聡; 筒井裕之
臨床化学, 36, Suppl.2, 193, 193, (一社)日本臨床化学会, Oct. 2007
Japanese

左室収縮不全のない心疾患患者におけるE/E'の意義左室充満圧と血流伝播速度との比較に基づく検討
井上真美子; 山田聡; 三神大世; 小室薫; 小松博史; 岡田昌子; 横山しのぶ; 加賀早苗; 西田睦; 北村忠代; 清水力; 千葉仁志; 小野塚久夫; 筒井裕之
超音波医学, 34, 4, 471, 472, (公社)日本超音波医学会, Jul. 2007
Japanese

肥大心における右室局所機能 2次元スペックルトラッキング法に基づく検討
加賀早苗; 三神大世; 小野塚久夫; 井上真美子; 横山しのぶ; 西田睦; 北村忠代; 清水力; 千葉仁志; 小松博史; 岡田昌子; 山田聡; 筒井裕之
超音波医学, 34, 4, 472, 472, (公社)日本超音波医学会, Jul. 2007
Japanese

心エコーで発見し手術で確認された心外膜下心室瘤の1例
井上真美子; 三神大世; 岡田昌子; 小松博史; 山田聡; 小野塚久夫; 筒井裕之; 横山しのぶ; 加賀早苗; 西田睦; 北村忠代; 清水力; 千葉仁志; 松居喜郎
超音波検査技術, 32, 3, 386, 386, (一社)日本超音波検査学会, Jun. 2007
Japanese

LevovistとSonazoid造影超音波(US)画像の対比検討
西田睦; 増田香織; 佐藤恵美; 溝口恵美; 加賀早苗; 井上真美子; 横山しのぶ; 北村忠代; 清水力; 千葉仁志
超音波検査技術, 32, 2, 200, 200, (一社)日本超音波検査学会, Apr. 2007
Japanese

2次元スペックルトラッキング法による肥大心の右室収縮機能評価
加賀早苗; 三神大世; 小野塚久夫; 井上真美子; 横山しのぶ; 西田睦; 北村忠代; 清水力; 千葉仁志; 岡田昌子; 山田聡; 筒井裕之
超音波検査技術, 32, 2, 206, 206, (一社)日本超音波検査学会, Apr. 2007
Japanese

超音波診断装置精度管理点検表の試用経験
溝口恵美; 西田睦; 佐藤恵美; 増田香織; 横山しのぶ; 井上真美子; 加賀早苗; 北村忠代; 清水力; 千葉仁志
超音波検査技術, 32, 2, 228, 228, (一社)日本超音波検査学会, Apr. 2007
Japanese

心房細動患者におけるE/E'の1心拍計測は可能か?
横山しのぶ; 三神大世; 加賀早苗; 井上真美子; 西田睦; 北村忠代; 清水力; 千葉仁志; 小松博史; 岡田昌子; 山田聡; 小野塚久夫; 筒井裕之
超音波医学, 33, 6, 693, 693, (公社)日本超音波医学会, Nov. 2006
Japanese

2次元スペックルトラッキング法を用いて方向別にみた心筋局所収縮様式の部位差正常心と高血圧性肥大心における検討
加賀早苗; 三神大世; 井上真美子; 横山しのぶ; 阿部歩; 西田睦; 北村忠代; 清水力; 千葉仁志; 後藤数智; 小松博史; 岡田昌子; 山田聡; 小野塚久夫; 筒井裕之
超音波医学, 33, 6, 694, 694, (公社)日本超音波医学会, Nov. 2006
Japanese

造影超音波が有用であった消化管急性腹症の2例
西田睦; 清水力; 千葉仁志; 今井希一; 木村もと子; 新山智美; 佐川直美; 北村忠代; 井上真美子; 加賀早苗; 横山しのぶ
超音波医学, 33, 6, 698, 699, (公社)日本超音波医学会, Nov. 2006
Japanese

心房細動患者における左室拡張機能評価計測の簡略化の限界についての検討
横山しのぶ; 三神大世; 加賀早苗; 井上真美子; 西田睦; 北村忠代; 清水力; 千葉仁志; 小松博史; 岡田昌子; 山田聡; 小野塚久夫; 筒井裕之
臨床病理, 54, 補冊, 218, 218, (一社)日本臨床検査医学会, Oct. 2006
Japanese

Role of left ventricular regional diastolic abnormalities for global diastolic dysfunction in patients with hypertrophic cardiomyopathy
Kazutomo Goto; Taisei Mikami; Hisao Onozuka; Sanae Kaga; Mamiko Inoue; Hiroshi Komatsu; Kaoru Komuro; Satoshi Yamada; Hiroyuki Tsutsui; Akira Kitabatake
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, 19, 7, 857, 864, Jul. 2006, [Peer-reviewed]
English, Scientific journal

Increased plasma concentrations of N-terminal pro-brain natriuretic peptide reflect the presence of mildly reduced left ventricular diastolic function in hypertension
T Furumoto; S Fujii; T Mikami; M Inoue; K Nishihara; S Kaga; S Imagawa; K Goto; K Komuro; S Yamada; H Onozuka; A Kitabatake; BE Sobel
CORONARY ARTERY DISEASE, 17, 1, 45, 50, Feb. 2006, [Peer-reviewed]
English, Scientific journal

Dilation of the brachial artery in response to sublingual nitroglycerin can predict the antihypertensive effects of valsartan: A study using novel high-frequency high-frame-rate ultrasound imaging
Mamiko Inoue; Satoshi Fujii; Taisei Mikami; Tomoo Furumoto; Sanae Kaga; Hiroshi Komatsu; Kazutomo Goto; Kaoru Komuro; Satoshi Yamada; Hisao Onozuka; Akira Kitabatake; Hiroyuki Tsutsui
Journal of Cardiology, 47, 1, 9, 14, 1, 2006, [Peer-reviewed]
Japanese, Scientific journal

Usefulness of Left Parasternal Approach for the Continuous-Wave Doppler Measurement of Left Ventricular Outflow Tract Pressure Gradient in Patients With Hypertrophic Cardiomyopathy
ONOZUKA Hisao; MIKAMI Taisei; KAGA Sanae; YAMADA Satoshi; NISHIHARA Keiko; KOMURO Kaoru; INOUE Mamiko; TERANISHI Jun-ichi; URASAWA Kazushi; TSUTSUI Hiroyuki; KITABATAKE Akira
Journal of Echocardiography, 3, 4, 140, 147, Japanese Society of Echocardiography, 2005, [Peer-reviewed]
English, Background. The apical approach (ApA) has been usually employed for the continuous-wave Doppler (CWD) measurement of pressure gradient in the left ventricular outflow tract (LVOT) in patients with hypertrophic obstructive cardiomyopathy (HOCM). This study aimed to assess the usefulness of a left parasternal approach (LPA) using the most cranial part of the echo-window for the measurement of the LVOT pressure gradient.
Methods. CWD using LPA and ApA was performed in 19 patients with HOCM to measure LVOT peak pressure gradients (PG_LPA and PG_ApA, respectively) and record a signal of mitral regurgitation (MR). The beam incident angles to LVOT flow in LPA (θ_LPA) and in ApA (θ_ApA) were measured using color Doppler flow imaging.
Results. PG_LPA was distinctly greater (>= 10mmHg) than PG_ApA in 7 patients (37%); they were similar in 6 (32%); and PG_LPA was distinctly smaller (<= -10mmHg) than PG_ApA in 6 (32%). All patients had MR. While all the MR jets in ApA shifted away from the probe, i.e. to the same side of the LVOT flow, 18 of the 19 MR jets shifted to the opposite side of the LVOT flow, when using LPA. Cos θ_LPA was significantly smaller and Cos θ_ApA was significantly greater in the HOCM patients than 10 control subjects (p<0.001 for both). Both PG_LPA and PG_ApA correlated with the invasive pressure gradient (r=0.99 and r=0.97) in 7 patients who underwent invasive study. PG_LPA was closer to the invasive pressure gradient than PG_ApA in 6 patients.
Conclusions. LPA provided a more accurate measurement of pressure gradient than ApA in about one third of HOCM patients, probably due to the altered direction of LVOT flow in HOCM. LPA is also useful in distinguishing LVOT flow from MR jet commonly seen in these patients.

Prognostic Significance of Left Ventricular Diastolic Dysfunction Assessed by Color M-mode Doppler Echocardiography in Patients With Chronic Left Ventricular Systolic Dysfunction
Norifumi Hirao; Hisao Onozuka; Satoshi Yamada; Kaoru Komuro; Hiroshi Okamoto; Akira Kitabatake; Taisei Mikami; Sanae Kaga; Mamiko Inoue
Journal of Echocardiography, 2, 3, 68, 77, 2004, [Peer-reviewed]
English, Scientific journal

■ Other Activities and Achievements

Clinical implications of right atrial pressure propagation time from the inferior vena cava to the renal interlobar vein in diabetic patients
工藤悠輔; 工藤悠輔; 武藤里奈; 村山迪史; 表原里実; 岩井孝仁; 進藤由衣香; 砂後谷華奈; 三谷麻子; 加賀早苗; 豊嶋崇徳; 表原里実; 岩井孝仁; 進藤由衣香; 砂後谷華奈; 三谷麻子; 加賀早苗; 豊嶋崇徳; 豊嶋崇徳, 超音波医学 Supplement, 52, 2025

外来心臓リハビリテーションがHFpEF患者の心機能に与える影響
木村花海; 柳本幸太; 村山迪史; 樋岡拓馬; 樋岡拓馬; 立石優太; 阪口景太; 小野田愛梨; 種村明日香; 皆川七穂; 津田正哉; 福島新; 加賀早苗, 超音波検査技術, 50, 3, 2025

A novel ultrasound finding for the diagnosis of giant cell arteritis: Comparison with temporal artery biopsy findings
工藤悠輔; 工藤悠輔; 村山迪史; 加賀早苗; 加賀早苗; 表原里実; 表原里実; 岩井孝仁; 岩井孝仁; 進藤由衣香; 進藤由衣香; 砂後谷華奈; 砂後谷華奈; 西田睦; 豊嶋崇徳; 豊嶋崇徳; 豊嶋崇徳; 石津明洋, 超音波医学 Supplement, 51, 2024

Mechanism of portal venous flow pulsation in healthy adults: comparison with hepatic venous flow pattern
小野田愛梨; 村山迪史; 小林澄夏; 永井優衣; 塚本真帆; 阪口景太; 工藤悠輔; 加賀早苗; 加賀早苗, 超音波医学 Supplement, 51, 2024

Application of an Echocardiographic Scoring System of Left Ventricular Filling Pressure for Patients with Aortic Stenosis
青柳裕之; 岩野弘幸; 後藤真奈; 鈴木ゆき乃; 村山迪史; 横山しのぶ; 西野久雄; 中鉢雅大; 中村公亮; 玉置陽生; 本居昂; 石坂傑; 加賀早苗; 神谷究; 永井利幸; 安斉俊久, 日本循環器学会学術集会(Web), 87th, 2023

Head-to-head comparison between hepatic vein flow and superior vena cava flow patterns analysis for predicting elevated right atrial pressure
村山迪史; 村山迪史; 加賀早苗; 加賀早苗; 境田ひな; 小野田愛梨; 中鉢雅大; 西野久雄; 横山しのぶ; 石坂傑; 岩野弘幸; 岩野弘幸; 安斉俊久, 超音波医学 Supplement, 50, 2023

心不全患者における複数の超音波指標を組み合わせたうっ血肝診断モデルの確立
小野田愛梨; 村山迪史; 加賀早苗; 中鉢雅大; 横山しのぶ; 西野久雄; 石坂傑; 本居昴; 青柳裕之; 玉置陽生; 中村公亮; 岩野弘幸; 安斉俊久, 日本循環器学会学術集会(Web), 87th, 2023

超音波法を用いたスコアリングによるうっ血肝診断と予後予測
小野田愛梨; 村山迪史; 村山迪史; 加賀早苗; 加賀早苗; 工藤悠輔; 岩井孝仁; 中鉢雅大; 横山しのぶ; 西野久雄; 西田睦; 石坂傑; 岩野弘幸; 岩野弘幸; 安斉俊久, 日本超音波検査学会学術集会講演抄録集(Web), 48th, 2023

ガイドラインに基づく右房圧推定における副次的指標の再考
村山迪史; 村山迪史; 加賀早苗; 岡田一範; 小野田愛梨; 種村明日香; 中鉢雅大; 横山しのぶ; 西野久雄; 西田睦; 辻永真吾; 岩野弘幸; 岩野弘幸; 安斉俊久, 日本超音波検査学会学術集会講演抄録集(Web), 47th, 2022

肺動脈弁逆流速度波形に基づく抵抗-コンプライアンス時間推定値と予後との関連
阿部穂乃加; 塚本真帆; 村山迪史; 後藤真奈; 中鉢雅大; 西野久雄; 横山しのぶ; 加賀早苗, 日臨技北日本支部医学検査学会(Web), 10th, 2022

経胸壁三次元心エコー法を用いた三尖弁閉鎖不全症の逆流重症度評価の試み解剖学的逆流弁口面積計測の妥当性の検討
阪口景太; 村山迪史; 中鉢雅大; 西野久雄; 横山しのぶ; 後藤真奈; 加賀早苗, 日臨技北日本支部医学検査学会(Web), 10th, 2022

Influencing factors for the overestimation of severity of pulmonary regurgitation by Doppler echocardiography
本居昂; 岩野弘幸; 岩野弘幸; 常田慧徳; 村山迪史; 加賀早苗; 青柳裕之; 玉置陽生; 石坂傑; 千葉泰之; 辻永真吾; 種村明日香; 横山しのぶ; 中鉢雅大; 西野久雄; 岡田一範; 武田充人; 安斉俊久, 日本成人先天性心疾患学会雑誌(Web), 11, 1, 2022

Association between myocardial late gadolinium enhancement and left ventricular systolic dysfunction in pre-capillary pulmonary hypertension
新川未緒; 加賀早苗; 岩野弘幸; 千葉泰之; 宮本知佳; 岡田一範; 村山迪史; 村山迪史; 中鉢雅大; 常田慧徳; 辻野一三, 超音波医学 Supplement, 49, 2022

慢性心不全における右室cardiac power outputの意義
千葉泰之; 岩野弘幸; 岩野弘幸; 本居昂; 石坂傑; 辻永真吾; 村山迪史; 横山しのぶ; 中鉢雅大; 西野久雄; 岡田一範; 加賀早苗; 神谷究; 永井利幸; 安斉俊久, 日本心臓病学会学術集会(Web), 69th, 2021

Usefulness of a parameter based on visually assessed atrioventricular valve opening delay for prediction of left ventricular filling pressure in atrial fibrillation and mitral annular calcification
岩野弘幸; 村山迪史; 辻永真吾; 千葉泰之; 石坂傑; 本居昂; 中鉢雅大; 加賀早苗; 安斉俊久, 超音波医学 Supplement, 48, 2021

Influence of Advanced Pulmonary Vascular Remodeling on Accuracy of Echocardiographic Parameters of Left Ventricular Filling Pressure
Yasuyuki Chiba; Hiroyuki Iwano; Sanae Kaga; Mio Shinkawa; Michito Murayama; Hiroshi Ohira; Ko Motoi; Suguru Ishizaka; Shingo Tsujinaga; Shinobu Yokoyama; Masahiro Nakabachi; Hisao Nishino; Kazunori Okada; Kiwamu Kamiya; Toshiyuki Nagai; Toshihisa Anzai, CIRCULATION, 142, Nov. 2020
English, Summary international conference

Left Ventricular External Work as a Marker of Cardiac Functional Recovery and Outcome After Transcatheter Aortic Valve Replacement in Patients With Aortic Stenosis
Shingo Tsujinaga; Hiroyuki Iwano; Ko Motoi; Yasuyuki Chiba; Suguru Ishizaka; Michito Murayama; Masahiro Nakabachi; Shinobu Yokoyama; Hisao Nishino; Kazunori Okada; Sanae Kaga; Kiwamu Kamiya; Toshiyuki Nagai; Toshihisa Anzai, CIRCULATION, 142, Nov. 2020
English, Summary international conference

収縮期の右房容量負荷が三尖弁輪収縮期移動距離に及ぼす影響
村山迪史; 村山迪史; 加賀早苗; 岡田一範; 三神大世; 中鉢雅大; 横山しのぶ; 西野久雄; 西田睦; 澁谷斉; 辻永真吾; 岩野弘幸; 安斉俊久, 超音波検査技術, 45, 2, 2020

Simple Echocardiographic Scoring System to Estimate Left Ventricular Filling Pressure Based on Visual Assessment of Time-Difference Between Mitral and Tricuspid Valve Opening
村山迪史; 村山迪史; 岩野弘幸; 辻永真吾; 西野久雄; 中鉢雅大; 横山しのぶ; 西田睦; 渋谷斉; 加賀早苗; 安斉俊久, 超音波医学 Supplement, 47, 2020

Right Atrial Volume Overload during Ventricular Systole Alters the Relationship between Tricuspid Annular Plane Systolic Excursion and Right Ventricular Ejection Fraction: A Three-Dimensional Echocardiographic Study
村山迪史; 村山迪史; 加賀早苗; 岡田一範; 三神大世; 中鉢雅大; 横山しのぶ; 西野久雄; 西田睦; 岩野弘幸; 安斉俊久, 超音波医学 Supplement, 47, 2020

Novel non-invasive method to assess left atrial stiffness during reservoir phase using pulmonary venous flow
阿部剛大; 岡田一範; 加賀早苗; 政氏伸夫; 三神大世; 村山迪史; 中鉢雅大; 辻永真吾; 岩野弘幸; 安斉俊久, 超音波医学 Supplement, 47, 2020

心不全における肺動脈圧波形上のv波出現の意義に関する検討
岩野弘幸; 横山しのぶ; 石坂傑; 千葉泰之; 更科美羽; 辻永真吾; 中鉢雅大; 加賀早苗; 神谷究; 永井利幸; 安斉俊久, 日本心臓病学会学術集会抄録, 67回, O, 281, Sep. 2019
(一社)日本心臓病学会, Japanese

これからの超音波検査を牽引する人材の育成を目指す大学院教育
岡田一範; 加賀早苗; 政氏伸夫; 三神大世; 中鉢雅大; 村山迪史; 横山しのぶ; 西野久雄; 西田睦; 澁谷斉; 更科美羽; 辻永真吾; 岩野弘幸; 安斉俊久, 臨床検査学教育, 11, 2, 219, 226, Sep. 2019
(一社)日本臨床検査学教育協議会, Japanese

日常的な左室充満圧上昇判定における肺動脈弁逆流速度計測の意義
村山迪史; 加賀早苗; 岡田一範; 三神大世; 中鉢雅大; 横山しのぶ; 西野久雄; 辻永真吾; 西田睦; 澁谷斉; 岩野弘幸; 安斉俊久, 超音波検査技術, 44, Suppl., S139, S139, Apr. 2019
(一社)日本超音波検査学会, Japanese

三尖弁輪収縮期移動距離と三尖弁輪収縮期運動速度の計測に最も適する断面はどれか?
加賀早苗; 村山迪史; 岡田一範; 三神大世; 中鉢雅大; 西野久雄; 横山しのぶ; 辻永真吾; 岩野弘幸; 安斉俊久, 超音波医学, 46, Suppl., S616, S616, Apr. 2019
(公社)日本超音波医学会, Japanese

日常的な左室充満圧上昇判定における肺動脈弁逆流速度計測の意義
村山迪史; 加賀早苗; 岡田一範; 三神大世; 中鉢雅大; 横山しのぶ; 西野久雄; 辻永真吾; 西田睦; 澁谷斉; 岩野弘幸; 安斉俊久, 超音波検査技術, 44, Suppl., S139, S139, Apr. 2019
(一社)日本超音波検査学会, Japanese

Mechanisms of Ventilatory Efficiency during Exercise in Heart Failure: Comparison between Heart Failure with Preserved Ejection Fraction and Reduced Ejection Fraction(和訳中)
辻永真吾; 岩野弘幸; 更科美羽; 村山迪史; 中鉢雅大; 横山しのぶ; 西野久雄; 岡田一範; 加賀早苗; 福島新; 横田卓; 安斉俊久, 日本循環器学会学術集会抄録集, 83回, OJ08, 2, Mar. 2019
(一社)日本循環器学会, English

Prognostic Value of Novel Echocardiographic Index of Left Ventricular Operating Stiffness in Patients with Heart Failure(和訳中)
岡田一範; 藤澤亮介; 加賀早苗; 政氏伸夫; 三神大世; 村山迪史; 中鉢雅大; 西野久雄; 横山しのぶ; 更科美羽; 辻永真吾; 岩野弘幸; 安斉俊久, 日本循環器学会学術集会抄録集, 83回, OJ08, 7, Mar. 2019
(一社)日本循環器学会, English

Simple and Completely Noninvasive Method to Estimate Right Ventricular Operating Stiffness Based on Pulmonary Regurgitant Velocity and Tricuspid Annular Plane Movement Measurements During Atrial Contraction
Michito Murayama; Sanae Kaga; Kazunori Okada; Hisao Nishino; Shinobu Yokoyama; Masahiro Nakabachi; Miwa Sarashina; Shingo Tsujinaga; Mutsumi Nishida; Hitoshi Shibuya; Toshiyuki Nagai; Hiroyuki Iwano; Toshihisa Anzai; Taisei Mikami, CIRCULATION, 138, Nov. 2018
English, Summary international conference

混合性肺高血圧患者の左房心筋機能障害
加賀早苗; 岡田一範; 三神大世; 川村希実; 政氏伸夫; 村山迪史; 横山しのぶ; 岩野弘幸; 山田聡; 安斉俊久, 超音波医学, 45, Suppl., S604, S604, Apr. 2018
(公社)日本超音波医学会, Japanese

三次元心エコー法による肥大型心筋症のリザーバ期左房心筋伸展障害の実態と機序の検討
柳裕介; 岡田一範; 加賀早苗; 三神大世; 政氏伸夫; 西野久雄; 横山しのぶ; 岩野弘幸; 山田聡; 安斉俊久, 超音波医学, 45, Suppl., S618, S618, Apr. 2018
(公社)日本超音波医学会, Japanese

連続波ドップラーを用いた心房収縮前肺動脈-右室圧較差による肺動脈楔入圧の正確な推定(Accurate Estimation of Pulmonary Artery Wedge Pressure by Pre-Atrial Contraction Pulmonary Arterial-Right Ventricular Pressure Gradient Using Continuous-Wave Doppler)
村山迪史; 加賀早苗; 岡田一範; 市川絢子; 中鉢雅大; 横山しのぶ; 西野久雄; 更科美羽; 辻永真吾; 林大知; 岩野弘幸; 西田睦; 澁谷斉; 山田聡; 三神大世; 安斉俊久, 日本循環器学会学術集会抄録集, 82回, OJ25, 8, Mar. 2018
(一社)日本循環器学会, English

正常心および拡張心における左心室内拡張早期の渦の特性と重要性(Property and Significance of Intra-Left Ventricular Early-Diastolic Vortex in Normal and Dilated Heart)
更科美羽; 山田聡; 岩野弘幸; 岡田一範; 辻永真吾; 林大知; 村山迪史; 市川絢子; 中鉢雅大; 横山しのぶ; 西野久雄; 加賀早苗; 安斉俊久, 日本循環器学会学術集会抄録集, 82回, PJ001, 5, Mar. 2018
(一社)日本循環器学会, English

抗酸化剤、鉄キレート剤添加血液検体における血球計数の経時的変化
七戸加奈; 後藤美沙紀; 前田里衣; 橋ことみ; 菅野加奈絵; 西清孝; 邵旻蓉; 河野圭伍; 山本麻衣; 岡田一範; 加賀早苗; 政氏伸夫, 臨床血液, 58, 12, 2463, 2463, Dec. 2017
(一社)日本血液学会-東京事務局, Japanese

血液細胞画像のテクスチャ解析により作成した判定行列の判定能の検討
河野圭伍; 山本麻衣; 七戸加奈; 邵旻蓉; 村上悟; 早田瑠架; 三輪佳子; 堤豊; 岡田一範; 加賀早苗; 政氏伸夫, 臨床血液, 58, 12, 2464, 2464, Dec. 2017
(一社)日本血液学会-東京事務局, Japanese

フローサイトメトリーを用いた胎児赤血球計量系の構築
政氏伸夫; 馬詰武; 山田崇弘; 長和俊; 岡田一範; 加賀早苗; 森川守, 臨床血液, 58, 12, 2464, 2464, Dec. 2017
(一社)日本血液学会-東京事務局, Japanese

分類基準に準じて初学者が行った骨髄有核細胞鑑別の精度
七戸加奈; 邵旻蓉; 山本麻衣; 河野圭伍; 高橋一人; 堤豊; 三輪佳子; 加賀早苗; 岡田一範; 政氏伸夫, 臨床血液, 58, 11, 2296, 2296, Nov. 2017
(一社)日本血液学会-東京事務局, Japanese

分類基準に準じて初学者が行った正常末梢血白血球分類の精度
邵旻蓉; 七戸加奈; 山本麻衣; 河野圭伍; 高橋一人; 堤豊; 三輪佳子; 加賀早苗; 岡田一範; 政氏伸夫, 臨床血液, 58, 11, 2296, 2297, Nov. 2017
(一社)日本血液学会-東京事務局, Japanese

実例で学ぶ心エコー手法の適材適所左室収縮能―EF?GLS?
山田聡; 加賀早苗, 心エコー, 18, 8, 726‐735, 01 Aug. 2017
Japanese

凝固検査用検体の遠心条件と保管による凝固検査と残存血小板数の検討
山本麻衣; 黒木麻衣子; 河野圭伍; 七戸加奈; 三輪佳子; 高橋一人; 岡田一範; 加賀早苗; 三神大世; 家子正裕; 政氏伸夫, 日本検査血液学会雑誌, 18, 2, 258, 265, Jul. 2017
(一社)日本検査血液学会, Japanese

正常骨髄有核細胞分類における熟練検査技師間での差異
七戸加奈; 河野圭佑; 山本麻衣; 邵旻蓉; 黒木麻衣子; 高橋一人; 堤豊; 岡田一範; 加賀早苗; 政氏伸夫, 日本検査血液学会雑誌, 18, 学術集会, S175, S175, Jun. 2017
(一社)日本検査血液学会, Japanese

正常末梢血白血球分類における熟練検査技師間での差異
邵旻蓉; 山本麻衣; 河野圭伍; 黒木麻衣子; 七戸加奈; 高橋一人; 堤豊; 岡田一範; 加賀早苗; 政氏伸夫, 日本検査血液学会雑誌, 18, 学術集会, S176, S176, Jun. 2017
(一社)日本検査血液学会, Japanese

テクスチャ解析を用いた末梢血白血球形態の定量的定義と判別
山本麻衣; 河野圭伍; 早田瑠架; 村上悟; 黒木麻衣子; 七戸加奈; 邵旻蓉; 岡田一範; 加賀早苗; 政氏伸夫, 日本検査血液学会雑誌, 18, 学術集会, S187, S187, Jun. 2017
(一社)日本検査血液学会, Japanese

濃度共起行列を用いたテクスチャ解析による赤芽球系前駆細胞形態特徴の定量的定義と判別
河野圭伍; 早田瑠架; 村上悟; 山本麻衣; 黒木麻衣子; 邵旻蓉; 七戸加奈; 岡田一範; 加賀早苗; 政氏伸夫, 日本検査血液学会雑誌, 18, 学術集会, S236, S236, Jun. 2017
(一社)日本検査血液学会, Japanese

両室心筋ストレイン計測に基づく肺高血圧症の病型分類
加賀早苗; 前田祥子; 喜田真由子; 岡田一範; 政氏伸夫; 横山しのぶ; 西田睦; 浅川直也; 岩野弘幸; 山田聡; 辻野一三; 三神大世, 超音波検査技術, 42, S227, 01 Jun. 2017
Japanese

S字状中隔例の右室形態の特徴:3次元心エコー法を用いた検討
岡田一範; 加賀早苗; 辻田孝輔; 原瑞希; 長尾裕子; 坂本洋一; 政氏伸夫; 三神大世, 超音波検査技術, 42, S122, 01 Jun. 2017
Japanese

TEXTURE ANALYSIS FOR QUANTITATIVE DISTINCTION OF ERYTHROCYTE PRECURSOR CELL STAGES
Keigo Kono; Ruka Hayata; Satoru Murakami; Mai Yamamoto; Maiko Kuroki; Kana Nanato; Kazuto Takahashi; Keiko Miwa; Yutaka Tsutsumi; Kazunori Okada; Sanae Kaga; Nobuo Masauzi, INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, 39, 61, 61, May 2017
English, Summary international conference

TEXTURE ANALYSIS FOR QUANTITATIVE DISTINCTION OF THE MORPHOLOGICAL CHARACTERISTICS OF WHITE BLOOD CELLS IN PERIPHERAL BLOOD
Mai Yamamoto; Keigo Kono; Maiko Kuroki; Satoru Murakami; Ruka Hayata; Kana Nanato; Keiko Miwa; Kazuto Takahashi; Yutaka Tsutsumi; Kazunori Okada; Sanae Kaga; Nobuo Masauzi, INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, 39, 128, 128, May 2017
English, Summary international conference

年齢を考慮した血行動態推定のポイント
山田聡; 林大知; 加賀早苗; 岩野弘幸, 日本心エコー図学会学術集会プログラム・抄録集(Web), 28th, ROMBUNNO.S15‐5 (WEB ONLY), 2017
Japanese

心房収縮期における肺動脈弁逆流流速波形の窪みと三尖弁輪移動距離の計測に基づく右室拡張末期圧の推定
村山迪史; 三神大世; 加賀早苗; 岡田一範; 中鉢雅大; 西野久雄; 横山しのぶ; 市川絢子; 阿部歩; 辻永真吾; 林大知; 岩野弘幸; 山田聡, 日本心エコー図学会学術集会プログラム・抄録集(Web), 28th, ROMBUNNO.O31‐1 (WEB ONLY), 2017
Japanese

肺静脈血流と経僧帽弁血流の時間速度積分値計測に基づく心房収縮期逆行/順行血流量比の左室拡張末期圧推定における有用性
岡田一範; 加賀早苗; 安彦里佳; 阿部歩; 中鉢雅大; 西野久雄; 市川絢子; 横山しのぶ; 西田睦; 辻永真吾; 林大知; 浅川直也; 岩野弘幸; 山田聡; 三神大世, 日本心エコー図学会学術集会プログラム・抄録集(Web), 28th, ROMBUNNO.O24‐3 (WEB ONLY), 2017
Japanese

肺動脈弁逆流速度と経僧帽弁血流速度の計測に基づく新しい肺血管抵抗の非侵襲的推定法
黒壁大貴; 加賀早苗; 岡田一範; 政氏伸夫; 村山迪史; 喜田真由子; 横山しのぶ; 西野久雄; 中鉢雅大; 辻永真吾; 林大知; 浅川直也; 岩野弘幸; 山田聡; 辻野一三; 三神大世, 日本心エコー図学会学術集会プログラム・抄録集(Web), 28th, ROMBUNNO.O31.3 (WEB ONLY), 2017
Japanese

Additive Predictive Value of Strain Rate Dispersion Index for Responses to Cardiac Resynchronization Therapy: Substudy From the START Study
Hiroyuki Iwano; Satoshi Yamada; Kazunori Okada; Taichi Hayashi; Shingo Tsujinaga; Shinobu Yokoyama; Masahiro Nakabachi; Hisao Nishino; Ayako Ichikawa; Ayumu Abe; Sanae Kaga; Taisei Mikami; Hiroyuki Tsutsui, CIRCULATION, 134, Nov. 2016
English, Summary international conference

Single Beat Determination of Measurements of Echocardiographic Left Ventricular Diastolic Parameters in Patients With Atrial Fibrillation
Satoshi Yamada; Ayako Ichikawa; Hiroyuki Iwano; Kazunori Okada; Shinobu Yokoyama; Hisao Nishino; Masahiro Nakabachi; Ayumu Abe; Taichi Hayashi; Daisuke Murai; Sanae Kaga; Taisei Mikami; Hiroyuki Tsutsui, CIRCULATION, 134, Nov. 2016
English, Summary international conference

ドプラ法における匠の技〈基礎編〉各種ドプラ法の原理と使い方カラーMモードドプラ法
加賀早苗; 岩野弘幸; 三神大世, 心エコー, 17, 11, 974, 980, Nov. 2016
(株)文光堂, Japanese

テクスチャ識別指標を用いた骨髄球系幼若細胞形態の定量的定義の試み
河野圭伍; 村上悟; 早田瑠架; 黒木麻衣子; 山本麻衣; 岡田一範; 加賀早苗; 三神大世; 政氏伸夫, 日本検査血液学会雑誌, 17, 学術集会, S141, S141, Jul. 2016
(一社)日本検査血液学会, Japanese

凝固検査用検体の遠心条件と保管に関する検討 PT、APTT
黒木麻衣子; 河野圭伍; 山本麻衣; 岡田一範; 加賀早苗; 三輪佳子; 三神大世; 政氏伸夫, 日本検査血液学会雑誌, 17, 学術集会, S203, S203, Jul. 2016
(一社)日本検査血液学会, Japanese

凝固検査用検体の遠心条件と保管に関する検討 Fib、Ca再加時間
山本麻衣; 黒木麻衣子; 河野圭伍; 岡田一範; 加賀早苗; 三輪佳子; 三神大世; 政氏伸夫, 日本検査血液学会雑誌, 17, 学術集会, S203, S203, Jul. 2016
(一社)日本検査血液学会, Japanese

NUMERICAL DEFINITIONS OF MORPHOLOGICAL CHARACTERISTICS (MCS) OF GRANULOCYTE PRECURSOR CELLS (GPCS) WITH TEXTURE ANALYSIS (TXA) USING GRAY LEVEL CO-OCCURRENCE MATRIX (GLCM)
Keigo Kono; Satoru Murakami; Ruka Hayata; Mai Yamamoto; Kazunori Okada; Sanae Kaga; Taisei Mikami; Nobuo Masauzi, INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, 38, 57, 57, May 2016
English, Summary international conference

SEMI-AUTOMATIC RATING AND SCORING METHOD FOR NEUTROPHIL ALKALINE PHOSPHATASE (NAP) ACTIVITY AND INDEX
Kanae Sugano; Kotomi Hashi; Misaki Goto; Kiyotaka Nishi; Rie Maeda; Keigo Kohno; Mai Yamamoto; Kazunori Okada; Sanae Kaga; Taisei Mikami; Nobuo Masauzi, INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, 38, 102, 103, May 2016
English, Summary international conference

心不全患者における低心拍出量と静脈圧上昇の肝・腎障害との関係
米田球士; 三神大世; 加賀早苗; 岡田一範; 政氏伸夫; 横山しのぶ; 西田睦; 岩野弘幸; 山田聡; 筒井裕之, 超音波医学, 43, S607(J‐STAGE), 15 Apr. 2016
Japanese

左室肥大における心筋機能と心腔機能の関連
岡田一範; 山田聡; 岩野弘幸; 村井大輔; 西野久雄; 中鉢雅大; 林大知; 加賀早苗; 三神大世; 筒井裕之, 超音波医学, 43, S266(J‐STAGE), 15 Apr. 2016
Japanese

今こそ知りたい右心機能の重要性と評価法 3.心エコーによる右心機能評価 1)肺高血圧の推定と注意点
加賀早苗; 三神大世, Medical Technology, 44, 3, 249‐254, 15 Mar. 2016
Japanese

三尖弁と右室機能三尖弁逆流の評価
加賀早苗; 三神大世, 心エコー, 17, 3, 212‐218, 01 Mar. 2016
Japanese

検体、標本保管に伴うミエロペルオキシダーゼ染色強度の経時的安定性市販染色キットでの検討
橋ことみ; 西清孝; 後藤美沙紀; 前田里衣; 菅野加奈絵; 山田実早希; 福井彩佳; 藤本奈緒; 岡田一範; 加賀早苗; 三神大世; 政氏伸夫, 日本検査血液学会雑誌, 17, 1, 25, 35, Feb. 2016
(一社)日本検査血液学会, Japanese

肺静脈血流速度計測に基づく左室硬さの新しい指標の有用性
安彦里佳; 岡田一範; 三神大世; 加賀早苗; 横山しのぶ; 西田睦; 岩野弘幸; 榊原守; 山田聡; 筒井裕之, 超音波医学, 43, 1, 126, 127, 15 Jan. 2016
Japanese

連続波ドプラ法による肺動脈弁逆流速度計測に基づく肺動脈圧推定の意義
黒壁大貴; 加賀早苗; 三神大世; 岡田一範; 村山迪史; 樋岡拓馬; 横山しのぶ; 榊原守; 山田聡; 筒井裕之, 超音波医学, 43, 1, 125, 15 Jan. 2016
Japanese

肺動脈弁逆流速度計測に基づく新しい肺血管抵抗の非侵襲的推定法
前田理菜; 加賀早苗; 三神大世; 岡田一範; 樋岡拓馬; 村山迪史; 横山しのぶ; 榊原守; 山田聡; 筒井裕之, 超音波医学, 43, 1, 125, 15 Jan. 2016
Japanese

心エコー法による前毛細管性肺高血圧症と後毛細管性肺高血圧症との鑑別
早坂美咲; 加賀早苗; 三神大世; 喜田真由子; 岡田一範; 政氏伸夫; 横山しのぶ; 岩野弘幸; 山田聡; 筒井裕之, 超音波医学, 43, 1, 125, 126, 15 Jan. 2016
Japanese

肺動脈弁拡張期開放の意義を圧データとの対比に基づいて検討し得た心不全の3例
西野久雄; 岩野弘幸; 山田聡; 林大知; 中鉢雅大; 横山しのぶ; 市川絢子; 村井大輔; 岡田一範; 加賀早苗; 西田睦; 澁谷斉; 加畑馨; 三神大世; 清水力; 筒井裕之, 日本心エコー図学会学術集会プログラム・抄録集(Web), 27th, 152 (WEB ONLY), 2016
Japanese

心エコー法による収縮期と急速充満期の肺動脈圧推定と左房容積計測は肺高血圧症の診断と病型分類に有用である
喜田真由子; 三神大世; 加賀早苗; 岡田一範; 村山迪史; 横山しのぶ; 西野久雄; 中鉢雅大; 林大知; 村井大輔; 岩野弘幸; 榊原守; 山田聡; 辻野一三; 筒井裕之, 日本心エコー図学会学術集会プログラム・抄録集(Web), 27th, 234 (WEB ONLY), 2016
Japanese

肺動脈拡張期圧の推定における心房収縮直前時相での肺動脈弁逆流速度計測の有用性
村山迪史; 三神大世; 加賀早苗; 岡田一範; 樋岡拓馬; 中鉢雅大; 西野久雄; 横山しのぶ; 市川絢子; 阿部歩; 西田睦; 村井大輔; 林大知; 岩野弘幸; 榊原守; 山田聡; 筒井裕之, 日本心エコー図学会学術集会プログラム・抄録集(Web), 27th, 152 (WEB ONLY), 2016
Japanese

肺静脈血流と経僧帽弁血流の時間速度積分値計測に基づく新しい左室硬さ指標の有用性
岡田一範; 三神大世; 安彦里佳; 加賀早苗; 阿部歩; 中鉢雅大; 西野久雄; 横山しのぶ; 市川絢子; 西田睦; 村井大輔; 林大知; 岩野弘幸; 榊原守; 山田聡; 筒井裕之, 日本心エコー図学会学術集会プログラム・抄録集(Web), 27th, 177 (WEB ONLY), 2016
Japanese

心房細動患者における左室拡張機能評価:時短時代に代表的心拍をいかに選ぶか?
市川絢子; 山田聡; 岡田一範; 岩野弘幸; 横山しのぶ; 西野久雄; 中鉢雅大; 阿部歩; 林大知; 村井大輔; 加賀早苗; 西田睦; 澁谷斉; 加畑馨; 清水力; 三神大世; 筒井裕之, 日本心エコー図学会学術集会プログラム・抄録集(Web), 27th, 144 (WEB ONLY), 2016
Japanese

肺動脈弁逆流速度計測に基づく新しい肺血管抵抗の推定法
加賀早苗; 三神大世; 岡田一範; 村山迪史; 樋岡拓馬; 阿部歩; 市川絢子; 中鉢雅大; 西野久雄; 横山しのぶ; 西田睦; 村井大輔; 林大知; 岩野弘幸; 榊原守; 山田聡; 筒井裕之, 日本心エコー図学会学術集会プログラム・抄録集(Web), 27th, 141 (WEB ONLY), 2016
Japanese

テクスチャ解析を用いた好中球アルカリホスファターゼ(NAP)活性度判定システム
村上悟; 河野圭吾; 早田瑠架; 菅野加奈絵; 橋ことみ; 後藤実早希; 前田里衣; 西清孝; 加賀早苗; 政氏伸夫, 臨床血液, 56, 12, 2521, 2522, Dec. 2015
(一社)日本血液学会-東京事務局, Japanese

テクスチャ解析を用いた赤芽球系前駆細胞の判定システム
早田瑠架; 河野圭伍; 村上悟; 岡田一範; 加賀早苗; 三神大世; 政氏伸夫, 臨床血液, 56, 12, 2522, 2522, Dec. 2015
(一社)日本血液学会-東京事務局, Japanese

テクスチャ解析を用いた顆粒球系前駆細胞の判定システム
河野圭伍; 村上悟; 早田瑠架; 岡田一範; 加賀早苗; 三神大世; 政氏伸夫, 臨床血液, 56, 12, 2522, 2522, Dec. 2015
(一社)日本血液学会-東京事務局, Japanese

Comparison of Afterload Dependency Between Left Ventricular Myocardial Strain and Strain Rate in Healthy Subjects
Daisuke Murai; Satoshi Yamada; Hiroyuki Iwano; Taichi Hayashi; Kazunori Okada; Hisao Nishino; Masahiro Nakabachi; Ayumu Abe; Ayako Ichikawa; Shinobu Yokoyama; Sanae Kaga; Taisei Mikami; Hiroyuki Tsutsui, CIRCULATION, 132, Nov. 2015
English, Summary international conference

汎用画像処理ソフトを用いた細胞質内空胞の半自動分画・計測法
政氏伸夫; 水上真喜; 山田実早希; 福井彩佳; 藤本奈緒; 河野圭伍; 村上悟; 早田瑠架; 加賀早苗, 日本検査血液学会雑誌, 16, 学術集会, S163, S163, Jun. 2015
(一社)日本検査血液学会, Japanese

北海道内主要病院の末梢血検査に関するアンケート調査
河野圭伍; 村上悟; 早田瑠架; 加賀早苗; 政氏伸夫, 日本検査血液学会雑誌, 16, 学術集会, S183, S183, Jun. 2015
(一社)日本検査血液学会, Japanese

北海道内主要病院の骨髄検査に関するアンケート調査
村上悟; 河野圭伍; 早田瑠架; 加賀早苗; 政氏伸夫, 日本検査血液学会雑誌, 16, 学術集会, S184, S184, Jun. 2015
(一社)日本検査血液学会, Japanese

北海道内主要病院の血液形態検査に使用する機器・設備に関するアンケート調査
早田瑠架; 河野圭伍; 村上悟; 加賀早苗; 政氏伸夫, 日本検査血液学会雑誌, 16, 学術集会, S184, S184, Jun. 2015
(一社)日本検査血液学会, Japanese

道内医療機関の末梢血検査に関するアンケート調査
河野圭伍; 村上悟; 早田瑠架; 加賀早苗; 政氏伸夫, 臨床血液, 56, 6, 720, 720, Jun. 2015
(一社)日本血液学会-東京事務局, Japanese

道内医療機関の骨髄検査に関するアンケート調査
村上悟; 河野圭伍; 早田瑠架; 加賀早苗; 政氏伸夫, 臨床血液, 56, 6, 720, 720, Jun. 2015
(一社)日本血液学会-東京事務局, Japanese

道内医療機関における血液形態検査と使用機器・設備に関するアンケート調査
早田瑠架; 河野圭伍; 村上悟; 加賀早苗; 政氏伸夫, 臨床血液, 56, 6, 720, 720, Jun. 2015
(一社)日本血液学会-東京事務局, Japanese

腎障害の合併が大動脈弁狭窄症患者の心形態・機能に及ぼす影響
片山拓也; 三神大世; 加賀早苗; 岡田一範; 政氏伸夫; 横山しのぶ; 西田睦; 岩野弘幸; 山田聡; 筒井裕之, 超音波医学, 42, S514(J-STAGE), 15 Apr. 2015
Japanese

三尖弁通過リードと三尖弁逆流との関係:心エコー法による検討
米田球士; 三神大世; 加賀早苗; 岡田一範; 西田翼; 横山しのぶ; 西野久雄; 西田睦; 山田聡; 筒井裕之, 超音波医学, 42, 1, 84, 85, 15 Jan. 2015
Japanese

大動脈弁狭窄症患者における腎障害の合併が心臓の形態と機能に及ぼす影響
西村一美; 三神大世; 加賀早苗; 岡田一範; 片山拓也; 横山しのぶ; 西野久雄; 西田睦; 山田聡; 筒井裕之, 超音波医学, 42, 1, 85, 15 Jan. 2015
Japanese

三尖弁逆流の程度が連続波ドプラ法の右室収縮期圧推定に及ぼす影響:心カテーテル法との比較に基づく検討
村山迪史; 三神大世; 加賀早苗; 岡田一範; 樋岡拓馬; 横山しのぶ; 西田睦; 榊原守; 山田聡; 筒井裕之, 超音波医学, 42, 1, 85, 15 Jan. 2015
Japanese

超音波による肝臓脂肪の定量的指標CAP(Controlled Attenuation Parameter)の検者間再現性
伊藤佳澄; 西田睦; 工藤悠輔; 井上真美子; 表原里実; 岡田一範; 加賀早苗; 渋谷斉; 清水力; 三神大世, 超音波医学, 42, 1, 89, 15 Jan. 2015
Japanese

肥大型心筋症における左室心筋短縮速度の時間推移波形の特徴:長軸方向と短軸円周方向の差異
岡田一範; 三神大世; 加賀早苗; 阿部歩; 西田睦; 林大知; 村井大輔; 岩野弘幸; 山田聡; 筒井裕之, 超音波医学, 42, 1, 87, 15 Jan. 2015
Japanese

肝硬変患者に合併する肺高血圧症の心エコーによる病態分析
喜田真由子; 三神大世; 岡田一範; 加賀早苗; 竹村盛二朗; 横山しのぶ; 西野久雄; 西田睦; 山田聡; 筒井裕之, 超音波医学, 42, 1, 87, 15 Jan. 2015
Japanese

連続の式を用いて計測した大動脈弁口面積の誤差とその要因
大原彩友美; 三神大世; 加賀早苗; 岡田一範; 片山拓也; 横山しのぶ; 西野久雄; 西田睦; 山田聡; 筒井裕之, 超音波医学, 42, 1, 85, 15 Jan. 2015
Japanese

血圧変動による壁応力とスペックルストレインの変化:健常者での応力―ストレイン関係の検討
村井大輔; 山田聡; 林大知; 岡田一範; 西野久雄; 中鉢雅大; 阿部歩; 市川絢子; 横山しのぶ; 加賀早苗; 岩野弘幸; 三神大世; 筒井裕之, 日本心エコー図学会学術集会抄録集, 26th, 159, 2015
Japanese

S字状心室中隔に伴う左室流出路狭窄と弁穿孔による僧帽弁逆流が溶血性貧血の原因となった僧帽弁形成術後症例
横山しのぶ; 山田聡; 岩野弘幸; 新宮康栄; 阿部歩; 市川絢子; 中鉢雅大; 西野久雄; 岡田一範; 加賀早苗; 林大知; 村井大輔; 若狭哲; 西田睦; 澁谷斉; 重松明男; 清水力; 三神大世; 筒井裕之; 松居喜郎, 日本心エコー図学会学術集会抄録集, 26th, 250, 2015
Japanese

肝硬変患者における左室形態の多様性
竹村盛二朗; 三神大世; 岡田一範; 加賀早苗; 阿部歩; 中鉢雅大; 西野久雄; 横山しのぶ; 西田睦; 岩野弘幸; 山田聡; 筒井裕之, 日本心エコー図学会学術集会抄録集, 26th, 178, 2015
Japanese

基礎疾患で考える:膠原病
加賀早苗, 日本心エコー図学会学術集会抄録集, 26th, 118, 2015
Japanese

高度三尖弁逆流が連続波ドプラ法による収縮期右室‐右房圧較差計測に及ぼす影響とその対策
樋岡拓馬; 三神大世; 加賀早苗; 岡田一範; 村山迪史; 横山しのぶ; 西野久雄; 中鉢雅大; 西田睦; 榊原守; 山田聡; 筒井裕之, 日本心エコー図学会学術集会抄録集, 26th, 179, 2015
Japanese

肥大型心筋症における心血管合併症と心筋ストレインの関連:左室グローバルおよび局所ストレインとそのばらつきの検討
西野久雄; 山田聡; 岡田一範; 岩野弘幸; 村井大輔; 林大知; 阿部歩; 市川絢子; 中鉢雅大; 横山しのぶ; 加賀早苗; 西田睦; 渋谷斉; 清水力; 三神大世; 筒井裕之, 日本心臓病学会学術集会(Web), 63rd, ROMBUNNO.P‐691 (WEB ONLY), 2015
Japanese

心房細動例での左室拡張機能評価に有効な代表心拍の決定法:各指標の心周期変動に対する依存性の比較に基づく検討
市川絢子; 山田聡; 横山しのぶ; 阿部歩; 岡田一範; 西野久雄; 中鉢雅大; 加賀早苗; 西田睦; 澁谷斉; 清水力; 林大知; 村井大輔; 岩野弘幸; 三神大世; 筒井裕之, 日本心臓病学会学術集会(Web), 63rd, ROMBUNNO.P‐120 (WEB ONLY), 2015
Japanese

Left Ventricular Longitudinal Myocardial Workload is More Severely Reduced in Hypertensive Patients with Concentric Hypertrophy Than in Those with Eccentric Hypertrophy
Satoshi Yamada; Kazunori Okada; Hisao Nishino; Hiroyuki Iwano; Daisuke Murai; Taichi Hayashi; Masahiro Nakabachi; Ayako Ichikawa; Shinobu Yokoyama; Sanae Kaga; Taisei Mikami; Hiroyuki Tsutsui, CIRCULATION, 130, Nov. 2014
English, Summary international conference

Impaired Intrinsic Myocardial Shortening in Both Two Directions and Compensatory Mechanism to Maintain Left Ventricular Ejection Fraction in Patients With Hypertensive Heart Disease
Satoshi Yamada; Kazunori Okada; Hisao Nishino; Hiroyuki Iwano; Daisuke Murai; Taichi Hayashi; Masahiro Nakabachi; Ayako Ichikawa; Shinobu Yokoyama; Sanae Kaga; Taisei Mikami; Hiroyuki Tsutsui, CIRCULATION, 130, Nov. 2014
English, Summary international conference

心エコーでとこまでみるか―評価項目は?検査時間は?患者さんへの気遣いは?心不全が疑わしい場合
加賀早苗; 山田聡, 心エコー, 15, 5, 422, 433, 01 May 2014
Japanese

拡張能評価Up‐Date
加賀早苗, 医学検査, 63, ROMBUNNO.GAKKAICHOTOKUBETSUKIKAKU,SHINZO,KAGA, 25 Apr. 2014
Japanese

肝硬変患者の心臓形態・機能異常の特徴
竹村盛二朗; 三神大世; 岡田一範; 加賀早苗; 中鉢雅大; 西野久雄; 横山しのぶ; 西田睦; 山田聡; 筒井裕之, 超音波医学, 41, S508, 15 Apr. 2014
Japanese

機能的三尖弁逆流の機序:弁テザリングか弁輪拡大か?
西田翼; 三神大世; 加賀早苗; 中元雅章; 岡田一範; 阿部歩; 中鉢雅大; 西野久雄; 横山しのぶ; 西田睦; 岩野弘幸; 山田聡; 筒井裕之, 超音波医学, 41, 1, 51, 15 Jan. 2014
Japanese

高度三尖弁逆流例における右室‐右房圧較差の連続波ドプラ計測はどこまで信頼できるか
樋岡拓馬; 加賀早苗; 三神大世; 中野彩; 岡田一範; 阿部歩; 中鉢雅大; 西野久雄; 横山しのぶ; 西田睦; 林大知; 村井大輔; 山田聡; 筒井裕之, 超音波医学, 41, 1, 51, 15 Jan. 2014
Japanese

肝硬変患者において心エコー検査で検出される心形態・機能異常の特徴
竹村盛二朗; 三神大世; 大野瞬; 岡田一範; 加賀早苗; 阿部歩; 中鉢雅大; 西野久雄; 横山しのぶ; 西田睦; 林大知; 村井大輔; 山田聡; 筒井裕之, 超音波医学, 41, 1, 54, 15 Jan. 2014
Japanese

肥大心における左室長軸方向収縮速度の時相的変化の特徴
岡田一範; 三神大世; 加賀早苗; 阿部歩; 中鉢雅大; 西野久雄; 横山しのぶ; 西田睦; 林大知; 村井大輔; 山田聡; 筒井裕之, 超音波医学, 41, 1, 51, 15 Jan. 2014
Japanese

肺動脈弁逆流速波形が拘束型血行動態の診断に有用であった心アミロイドーシスの1例
西野久雄; 山田聡; 林大知; 村井大輔; 市川絢子; 中鉢雅大; 横山しのぶ; 加賀早苗; 西田睦; 清水力; 三神大世; 筒井裕之, 超音波医学, 41, 1, 52, 15 Jan. 2014
Japanese

加齢変性による大動脈弁狭窄症の収縮期弁口形態と狭窄重症度との関係
辻香菜子; 三神大世; 加賀早苗; 長多真美; 阿部歩; 岡田一範; 横山しのぶ; 西野久雄; 中鉢雅大; 西田睦; 岩野弘幸; 山田聡; 筒井裕之, 超音波医学, 41, 1, 53, 15 Jan. 2014
Japanese

高血圧における長軸方向心筋短縮能は遠心性肥大より求心性肥大でより高度に低下する
岡田一範; 山田聡; 西野久雄; 村井大輔; 林大知; 中鉢雅大; 横山しのぶ; 加賀早苗; 三神大世; 筒井裕之, 日本心エコー図学会学術集会抄録集, 25th, 191, 2014
Japanese

大動脈弁狭窄の診療における弁‐動脈インピーダンスの意義:左室肥大との関連について
市川絢子; 山田聡; 阿部歩; 辻香菜子; 岡田一範; 横山しのぶ; 西野久雄; 中鉢雅大; 加賀早苗; 西田睦; 澁谷斉; 清水力; 林大知; 村井大輔; 三神大世; 筒井裕之, 日本心エコー図学会学術集会抄録集, 25th, 239, 2014
Japanese

スペックルトラッキング法を用いた長軸方向心筋仕事量算出の試み:高血圧性心疾患と肥大型心筋症への応用
西野久雄; 山田聡; 岡田一範; 村井大輔; 林大知; 市川絢子; 中鉢雅大; 横山しのぶ; 加賀早苗; 西田睦; 清水力; 三神大世; 筒井裕之, 日本心エコー図学会学術集会抄録集, 25th, 191, 2014
Japanese

どのくらい高度の三尖弁逆流まで連続波ドプラ法による右室‐右房圧較差の評価は可能か?
加賀早苗; 三神大世; 樋岡拓馬; 中野彩; 岡田一範; 阿部歩; 中鉢雅大; 西野久雄; 横山しのぶ; 西田睦; 林大知; 村井大輔; 岩野弘幸; 山田聡; 筒井裕之, 日本心エコー図学会学術集会抄録集, 25th, 210, 2014
Japanese

肥大型心筋症における左室長軸方向ストレインレートの時相・波形異常の特徴
岡田一範; 三神大世; 加賀早苗; 阿部歩; 中鉢雅大; 西野久雄; 横山しのぶ; 西田睦; 林大知; 村井大輔; 山田聡; 筒井裕之, 日本心エコー図学会学術集会抄録集, 25th, 175, 2014
Japanese

Relationship Between Left Ventricular Myocardial Shortening in the Three Orthogonal Directions and Cardiovascular Complications in Patients With Nonobstructive Hypertrophic Cardiomyopathy
Hisao Nishino; Satoshi Yamada; Kazunori Okada; Masahiro Nakabachi; Shinobu Yokoyama; Hiroyuki Iwano; Sanae Kaga; Mutsumi Nishida; Hitoshi Shibuya; Chikara Shimizu; Taisei Mikami; Hiroyuki Tsutsui, CIRCULATION, 128, 22, Nov. 2013
English, Summary international conference

頸動脈エコーによるプラークの異常な動きの評価:プラーク破綻から潰瘍に至る一連の危険な病変の診断における役割
村木睦子; 三神大世; 吉本哲之; 藤本真; 北口真弓; 菅原智子; 加賀早苗; 徳田耕一; 金子貞男; 柏葉武, Neurosonology, 26, Supplement, 111, 01 Jun. 2013
Japanese

連続波ドプラ法による肺動脈弁逆流速度波形の分析に基づく収縮性心膜炎の診断
加賀早苗; 三神大世; 高松由佳; 中鉢雅大; 横山しのぶ; 西野久雄; 西田睦; 岩野弘幸; 山田聡; 筒井裕之, 超音波医学, 40, S487, 15 Apr. 2013
Japanese

機能的三尖弁逆流の成因と病態の分析
野澤弥生; 三神大世; 加賀早苗; 岡田一範; 阿部歩; 中鉢雅大; 横山しのぶ; 西野久雄; 西田睦; 岩野弘幸; 山田聡; 筒井裕之, 超音波医学, 40, 1, 31, 15 Jan. 2013
Japanese

肺高血圧症の診断における連続波ドプラ法による肺動脈弁逆流の拡張期流速測定の意義
北南文絵; 三神大世; 加賀早苗; 柴瀟; 中野彩; 岡田一範; 阿部歩; 中鉢雅大; 横山しのぶ; 西野久雄; 西田睦; 岩野弘幸; 山田聡; 筒井裕之, 超音波医学, 40, 1, 31, 15 Jan. 2013
Japanese

肥大型心筋症では円周方向ではなく長軸方向左室心筋ストレインが心血管合併症の有無と関連する
西野久雄; 山田聡; 岡田一範; 岩野弘幸; 横山しのぶ; 中鉢雅大; 加賀早苗; 西田睦; 清水力; 三神大世; 筒井裕之, 超音波医学, 40, 1, 34, 15 Jan. 2013
Japanese

連続波ドプラ法による肺動脈弁逆流流速波形にみられる心房収縮期窪みとその近傍の波形変化
中野彩; 三神大世; 加賀早苗; 北南文絵; 岡田一範; 阿部歩; 横山しのぶ; 西野久雄; 西田睦; 岩野弘幸; 山田聡; 筒井裕之, 超音波医学, 40, 1, 34, 35, 15 Jan. 2013
Japanese

重症大動脈弁狭窄にみあう左室肥大の欠如:圧回復現象との関係
辻香菜子; 加賀早苗; 三神大世; 鎌田美穂; 阿部歩; 岡田一範; 横山しのぶ; 西野久雄; 西田睦; 岩野弘幸; 山田聡; 筒井裕之, 超音波医学, 40, 1, 30, 31, 15 Jan. 2013
Japanese

S字状中隔における左室流出路狭窄と左室形態との関係
竹村盛二朗; 三神大世; 岡田一範; 加賀早苗; 阿部歩; 中鉢雅大; 西野久雄; 横山しのぶ; 西田睦; 岩野弘幸; 山田聡; 筒井裕之, 超音波医学, 40, 1, 34, 15 Jan. 2013
Japanese

3次元スペックルトラッキングによる左室容積自動計測の有用性:同一画像データでの2次元用手トレース法との比較に基づく検討
中鉢雅大; 山田聡; 西野久雄; 岡田一範; 横山しのぶ; 西田睦; 渋谷斉; 清水力; 加賀早苗; 三神大世; 筒井裕之, 日本心エコー図学会学術集会抄録集, 24th, 162, 2013
Japanese

肺動脈弁逆流の拡張後期流速波形のバリエーションとその意義
中野彩; 三神大世; 加賀早苗; 北南文絵; 岡田一範; 阿部歩; 横山しのぶ; 西野久雄; 中鉢雅大; 山田聡; 筒井裕之, 日本心エコー図学会学術集会抄録集, 24th, 173, 2013
Japanese

機能的三尖弁逆流の成因と機序:とくに慢性心房細動の関与について
岡田一範; 三神大世; 加賀早苗; 野澤弥生; 西田翼; 阿部歩; 中鉢雅大; 西野久雄; 横山しのぶ; 西田睦; 山田聡; 筒井裕之, 日本心エコー図学会学術集会抄録集, 24th, 175, 2013
Japanese

エコースペックルトラッキング法により実現した多方向心筋ストレインの層別解析:その概念と臨床応用
山田聡; 阿部康彦; 岡田一範; 西野久雄; 中鉢雅大; 横山しのぶ; 加賀早苗; 三神大世; 筒井裕之, 日本心エコー図学会学術集会抄録集, 24th, 99, 2013
Japanese

Stress-Corrected Circumferential Myocardial Shortening is Reduced in All Layers in Patients with Hypertrophic Cardiomyopathy
Kazunori Okada; Satoshi Yamada; Hiroyuki Iwano; Hisao Nishino; Masahiro Nakabachi; Shinobu Yokoyama; Sanae Kaga; Taisei Mikami; Hiroyuki Tsutsui, CIRCULATION, 126, 21, Nov. 2012
English, Summary international conference

心臓再同期療法後のVV delay調整に苦慮した左脚ブロックの2例
岩野弘幸; 山田聡; 西野久雄; 横山しのぶ; 加賀早苗; 三神大世; 筒井裕之, 日本心エコー図学会学術集会抄録集, 23rd, 84, 2012
Japanese

子宮体癌に合併しヘパリン療法が奏効した無菌性血栓性心内膜炎の1例
横山しのぶ; 山田聡; 加賀早苗; 小田切哲二; 西野久雄; 岩野弘幸; 西田睦; 澁谷斉; 重松明男; 渡利英道; 小野塚久夫; 清水力; 三神大世; 筒井裕之, 日本心エコー図学会学術集会抄録集, 23rd, 211, 2012
Japanese

肥大型心筋症で低下した長軸・円周方向心筋短縮と壁厚増大による円周方向内膜機能の代償
岡田一範; 山田聡; 岩野弘幸; 加賀早苗; 横山しのぶ; 西野久雄; 小野塚久夫; 三神大世; 筒井裕之, 日本心エコー図学会学術集会抄録集, 23rd, 92, 2012
Japanese

拡張機能を見直す心エコーで左室弛緩能は評価可能か?
三神大世; 加賀早苗, 心エコー, 12, 12, 1126, 1132, 01 Dec. 2011
Japanese

S字状中隔と左室心筋弛緩との関係:二次元スペックルトラッキング法による検討
岡田一範; 三神大世; 加賀早苗; 小野塚久夫; 横山しのぶ; 西野久雄; 中鉢雅大; 岩野弘幸; 山田聡; 筒井裕之, 超音波医学, 38, 6, 675, 15 Nov. 2011
Japanese

子宮体癌に合併しヘパリン療法が奏効した無菌性血栓性心内膜炎の1例
横山しのぶ; 山田聡; 加賀早苗; 小田切哲二; 西野久雄; 岩野弘幸; 西田睦; 澁谷斉; 重松明男; 渡利英道; 小野塚久夫; 清水力; 三神大世; 筒井裕之, 超音波医学, 38, 6, 677, 15 Nov. 2011
Japanese

心筋層別ストレイン計測による心筋機能と心室機能の評価:肥大型心筋症における検討
岡田一範; 山田聡; 三神大世; 岩野弘幸; 小野塚久矢; 加賀早苗; 横山しのぶ; 西野久雄; 筒井裕之, 超音波医学, 38, 6, 675, 15 Nov. 2011
Japanese

心エコーで観察されるS字状中隔と体格指数との関係
水岡由佳理; 三神大世; 岡田一範; 小野塚久夫; 加賀早苗; 横山しのぶ; 西野久雄; 岩野弘幸; 山田聡; 筒井裕之, 超音波医学, 38, 6, 672, 673, 15 Nov. 2011
Japanese

収縮同期不全による左室全体収縮機能の損失分を表すストレインレート指標:心臓再同期療法慢性効果の予測
岩野弘幸; 山田聡; 西野久雄; 横山しのぶ; 加賀早苗; 小野塚久夫; 三神大世; 筒井裕之, 超音波医学, 38, 6, 676, 15 Nov. 2011
Japanese

心内膜側と中層の円周方向ストレインによる左室機能評価の意義:肥大型心筋症における検討
岡田一範; 山田聡; 三神大世; 岩野弘幸; 加賀早苗; 小野塚久夫; 横山しのぶ; 西野久雄; 筒井裕之, 日本心臓病学会誌, 6, Supplement 1, 339, 14 Aug. 2011
Japanese

肥大心における心筋中層ストレインによる心筋機能の評価:Endocardial indexesとの意義の違い
山田聡; 岡田一範; 三神大世; 岩野弘幸; 加賀早苗; 小野塚久夫; 横山しのぶ; 西野久雄; 筒井裕之, 日本心臓病学会誌, 6, Supplement 1, 157, 14 Aug. 2011
Japanese

各種成因に基づく左室収縮障害患者における左室後壁屈曲の頻度と機序
岩井孝仁; 三神大世; 小野塚久夫; 加賀早苗; 横山しのぶ; 西野久雄; 西田睦; 岩野弘幸; 山田聡; 筒井裕之, 超音波医学, 38, 3, 303, 15 May 2011
Japanese

等容弛緩期の左室心筋ストレインレートは急速流入期ストレインレートよりも良好に左室弛緩能と関連する
岩野弘幸; 山田聡; 西野久雄; 横山しのぶ; 加賀早苗; 小野塚久夫; 三神大世; 筒井裕之, 超音波医学, 38, 3, 304, 15 May 2011
Japanese

左室右房交通症の1例:肺高血圧症を伴う三尖弁逆流との鑑別について
西野久雄; 三神大世; 岩野弘幸; 山田聡; 筒井裕之; 小野塚久夫; 横山しのぶ; 加賀早苗; 西田睦; 松野一彦, 超音波医学, 38, 3, 304, 15 May 2011
Japanese

加齢による左室変形と左室弛緩機能との関係:二次元スペックルトラッキング法による検討
岡田一範; 三神大世; 加賀早苗; 小野塚久夫; 西野久雄; 横山しのぶ; 西田睦; 岩野弘幸; 山田聡; 筒井裕之, 超音波医学, 38, 3, 303, 304, 15 May 2011
Japanese

二次元スペックルトラッキング法を用いた左室心内膜全体の面積変化速度による弛緩能の推定
岩野弘幸; 山田聡; 西野久雄; 横山しのぶ; 加賀早苗; 小野塚久雄; 三神大世; 筒井裕之, 超音波医学, 38, 3, 304, 15 May 2011
Japanese

左室収縮障害患者における左室後壁の内腔への屈曲・突出の頻度,機序および臨床的意義
岩井孝仁; 三神大世; 小野塚久夫; 加賀早苗; 横山しのぶ; 西野久雄; 西田睦; 岩野弘幸; 山田聡; 筒井裕之, 超音波医学, 38, S346, 15 Apr. 2011
Japanese

収縮同期不全による左室全体収縮機能の損失分を表すストレインレート指標
岩野弘幸; 山田聡; 西野久雄; 横山しのぶ; 加賀早苗; 小野塚久夫; 三神大世; 筒井裕之, 超音波医学, 38, S229, 15 Apr. 2011
Japanese

体外式超音波による胃・大腸癌の進行度診断
西田睦; 加藤元嗣; 西田麗; 石坂香織; 佐藤恵美; 井上真美子; 工藤悠輔; 表原里実; 加賀早苗; 横山しのぶ; 西野久雄; 小野寺祐也; 寺江聡; 七戸俊明; 近藤哲; 久保田佳奈子; 松野吉宏, 超音波医学, 37, 1, 46, 15 Jan. 2010
Japanese

CT/MRIにて診断に到らなかった肝結節に対する造影超音波検査の位置づけ
西田睦; 小野寺祐也; 尾松徳彦; 佐藤恵美; 石坂香織; 溝口恵美; 工藤祐輔; 加賀早苗; 井上真美子; 横山しのぶ; 表原里美; 鈴木春樹; 清水力; 寺江聡; 久保田佳奈子; 松野吉宏; 松野一彦, 臨床病理, 56, 115, 31 Oct. 2008
Japanese

Plasma NT-proBNP concentration is a sensitive marker of diastolic dysfunction and arterial remodeling in hypertension
Tomoo Furumoto; Mamiko Inoue; Sanae Kaga; Satoshi Yamada; Hisao Onozuka; Miwako Fujii; Akiko Aita; Taisei Mikami; Satoshi Fujii; Burton E. Sobel; Hiroyuki Tsutsui, JOURNAL OF HYPERTENSION, 24, 305, 305, Dec. 2006
English, Summary international conference

PJ-169 Abnormal Apical Rotation in Patients with Left Ventricular Hypertrophy Determined by Two-Dimensional Ultrasound Speckle Tracking Imaging(Echo/Doppler-13 (I) PJ29,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
Goto Kazutomo; Mikami Taisei; Onozuka Hisao; Kaga Sanae; Inoue Mamiko; Yokoyama Shinobu; Komatsu Hiroshi; Yamada Satoshi; Tsutsui Hiroyuki, Circulation journal : official journal of the Japanese Circulation Society, 70, 531, 531, 01 Mar. 2006
Japanese Circulation Society, English

PE-584 Plasma NT-proBNP Concentration is a Sensitive Marker of Diastolic Dysfunction and Arterial Remodeling in Hypertension(Hypertension, clinical-7 (H) PE102,Poster Session (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
Furumoto Tomoo; Fujii Satoshi; Mikami Taisei; Inoue Mamiko; Nishihara Keiko; Kaga Sanae; Gotoh Kazutomo; Imagawa Shogo; Komuro Kaoru; Yamada Satoshi; Onozuka Hisao; Kitabatake Akira; Sobel Burton E; Tsutsui Hiroyuki, Circulation journal : official journal of the Japanese Circulation Society, 70, 478, 479, 01 Mar. 2006
Japanese Circulation Society, English

Increased plasma concentrations of N-terminal pro brain natriuretic peptide is a more sensitive marker of subclinical diastolic dysfunction and arterial remodeling in hypertension: Analytical performance comparison with BNP
T Furumoto; S Fujii; T Mikami; M Inoue; K Nishihara; S Kaga; K Goto; S Imagawa; K Komuro; S Yamada; H Onozuka; A Kitabatake; BE Sobel; H Tsutsui, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 47, 4, 372A, 372A, Feb. 2006
English, Summary international conference

PJ-135 Feasibility of the Assessment of Left Ventricular Diastolic Function Using Doppler-Derived Early Diastolic Peak Strain Rate(Echo/Doppler 6 (I) : PJ23)(Poster Session (Japanese))
Onozuka Hisao; Mikami Taisei; Kaga Sanae; Goto Kazutomo; Inoue Mamiko; Yokoyama Shinobu; Komuro Kaoru; Yamada Satoshi; Kitabatake Akira, Circulation journal : official journal of the Japanese Circulation Society, 68, 513, 513, 01 Mar. 2004
Japanese Circulation Society, English

OJ-392 A New Method to Measure Myocardial Strain along the Left Ventricular Circumference Using Tissue Doppler Echocardiography(Echo/Doppler 14 (I) : OJ48)(Oral Presentation (Japanese))
Onozuka Hisao; Mikami Taisei; Kaga Sanae; Gotoh Kazutomo; Yokoyama Shinobu; Mamiko Mamiko; Komuro Kaoru; Yamada Satoshi; Kitabatake Akira, Circulation journal : official journal of the Japanese Circulation Society, 68, 325, 325, 01 Mar. 2004
Japanese Circulation Society, English

PJ-020 Evaluation of Circumferential and Longitudinal Myocardial Contraction Using Tissue Doppler Strain Measurement in Patients with Generalized Left Ventricular Myocardial Impairment(Echo/Doppler 2 (I) : PJ4)(Poster Session (Japanese))
Goto Kazutomo; Mikami Taisei; Kaga Sanae; Onozuka Hisao; Yokoyama Shinobu; Inoue Mamiko; Komuro Kaoru; Yamada Satoshi; Kitabatake Akira, Circulation journal : official journal of the Japanese Circulation Society, 68, 484, 484, 01 Mar. 2004
Japanese Circulation Society, English

Usefulness of Color Tissue Doppler Imaging in the Assessment of Left Ventricular Diastolic Function : Comparison with Color M-Mode Doppler Technique
Onozuka Hisao; Mikami Taisei; Kaga Sanae; Goto Kazutomo; Wu Di; Inoue Mamiko; Komuro Kaoru; Yamada Satoshi; Kitabatake Akira, Circulation journal : official journal of the Japanese Circulation Society, 67, 613, 613, 01 Mar. 2003
Japanese Circulation Society, English

Abnormal Diastolic Flow Velocity Pattern in the Distal Left Anterior Descending Coronary Artery in Patients with Apical Hypertrophy
Goto Kazutomo; Onozuka Hisao; Mikami Taisei; Inoue Mamiko; Kaga Sanae; Wu Di; Komuro Kaoru; Yamada Satoshi; Kitabatake Akira, Circulation journal : official journal of the Japanese Circulation Society, 67, 326, 326, 01 Mar. 2003
Japanese Circulation Society, English

■ Books and other publications

心不全治療に心エコーを生かすQ&A115
加賀早苗
メジカルビュー, Apr. 2017, [Contributor]

JAMT技術教本シリーズ超音波検査症例集
加賀早苗, 僧帽弁狭窄症
じほう, 2016, [Contributor]

■ Lectures, oral presentations, etc.

右心系を極める～右心機能評価の断面設定と計測のポイント～
加賀早苗
日本心エコー図学会第29回学術集会, 18 Apr. 2018, Japanese, Nominated symposium
[Invited], [Domestic Conference]

心不全患者の生理機能検査データを読み解こう
加賀早苗
北海道臨床衛生検査技師会第14回しばれセミナー, 24 Feb. 2018, Japanese, Public discourse
[Invited], [Domestic Conference]

基礎疾患で考える：膠原病
加賀早苗
第26回日本心エコー図学会学術集会, 28 Mar. 2015, Japanese, Nominated symposium
[Invited], [Domestic Conference]

拡張機能Update
加賀早苗
第63回日本医学検査学会, 17 May 2014, Japanese, Nominated symposium
[Invited], [Domestic Conference]

肺高血圧症の心エコー検査の実際
加賀早苗
講演会「肺高血圧症と心エコー」, 21 Jul. 2012, Japanese, Public discourse
[Invited], [Domestic Conference]

■ Syllabus

循環機能検査学演習, 2024年, 修士課程, 保健科学院

循環機能検査学特論, 2024年, 修士課程, 保健科学院

医用画像科学特講, 2024年, 博士後期課程, 保健科学院

医用画像科学特講演習, 2024年, 博士後期課程, 保健科学院

技能修得到達度評価, 2024年, 学士課程, 医学部

臨床生理学Ⅱ, 2024年, 学士課程, 医学部

臨床生理学Ⅲ, 2024年, 学士課程, 医学部

画像検査学Ⅰ, 2024年, 学士課程, 医学部

画像検査学Ⅱ, 2024年, 学士課程, 医学部

画像検査学Ⅰ, 2024年, 学士課程, 医学部

生体機能学実習, 2024年, 学士課程, 医学部

臨床生理画像学実習Ⅱ, 2024年, 学士課程, 医学部

臨地実習（生理検査）, 2024年, 学士課程, 医学部

画像検査学Ⅱ, 2024年, 学士課程, 医学部

臨床生理画像学実習, 2024年, 学士課程, 医学部

臨床生理画像学実習Ⅰ, 2024年, 学士課程, 医学部

臨床生理学Ⅰ, 2024年, 学士課程, 医学部

生体機能学, 2024年, 学士課程, 医学部

臨床病態学Ⅰ, 2024年, 学士課程, 医学部

一般教育演習(ﾌﾚｯｼｭﾏﾝｾﾐﾅｰ), 2024年, 学士課程, 全学教育

医療安全管理学Ⅱ, 2024年, 学士課程, 医学部

■ Research Themes

心エコー法による左心不全患者の右室後負荷の包括的評価法の確立
科学研究費助成事業
01 Apr. 2019 - 31 Mar. 2023
加賀早苗
心不全は、心疾患による死亡の大半に関わる重篤かつ頻度の高い合併症であるが、最近、左心不全患者の予後が右室機能の良否に左右されることが注目されている。これは肺循環系が右室に与える後負荷に起因すると考えられる。従って、肺循環動態を精密に把握する意義は大きいと考えられる。本研究の目的は、左心不全患者の肺循環系が右室に与える後負荷を、非侵襲的な心エコー法で包括的に評価するための方法論を確立し、その右室機能や患者予後との関係を明らかにすることである。
肺循環動態指標のひとつである肺血管抵抗（PVR）と肺動脈キャパシタンスの積である抵抗-コンプライアンス時間（RCT）の算出法として、対数法と積算法とではRCT計測値に差があることが問題点として指摘されている。本研究では、簡易的な対数法と積算法で求めたRCTを、時定数τとして標準的に求めたRCTとの比較に基づき、その妥当性を検討した。右心カテーテル検査が施行され、良好な記録が得られた洞調律例46例を対象に、肺動脈圧波形から平均肺動脈楔入圧（PAWP）を差し引いた圧曲線を作成し、拡張期時定数τを求め、これを標準RCTとした。また、簡易的対数法により、拡張早期と心房収縮直前の二点の圧とその間の時間およびPAWPから簡易RCTを算出した。さらに、肺動脈収縮期圧、肺動脈拡張期圧、平均肺動脈圧、PAWP、1回拍出量および心拍出量から、PVRとPACをそれぞれ求め、それらの積を積算RCTとした。
全46例における標準RCTは0.28±0.14秒であり、簡易RCTは標準RCTとよく相関し（r＝0.93、p＜0.01）、標準RCTに対する加算誤差を示さなかった。積算RCTも標準RCTとよく対応したが（r＝0.76、p＜0.01）、標準RCTに対して正の加算誤差を認め、RCTを過大評価した。
日本学術振興会, 若手研究, 北海道大学, 19K20703

SEARCH

Kaga Sanae

Faculty of Health Sciences Health Sciences Medical Laboratory ScienceAssociate Professor

Researcher basic information

Research activity information

Faculty of Health Sciences　Health Sciences　Medical Laboratory Science Associate Professor