Research activity information

• Cardiorespiratory effects of intramuscular alfaxalone combined with low-dose medetomidine and butorphanol in dogs anesthetized with sevoflurane.
  Keiko Kato; Takaharu Itami; Norihiko Oyama; Kazuto Yamashita
  Open veterinary journal, 14, 5, 1251, 1258, May 2024, [International Magazine]
  English, Scientific journal, BACKGROUND: The intramuscular (IM) administration of 7.5-10 mg/kg of alfaxalone produces anesthetic effects that enable endotracheal intubation with mild cardiorespiratory depression in dogs. However, the effects of IM co-administration of medetomidine, butorphanol, and alfaxalone on cardiorespiratory function under inhalation anesthesia have not been studied. AIM: To assess the cardiorespiratory function following the IM co-administration of 5 μg/kg of medetomidine, 0.3 mg/kg of butorphanol, and 2.5 mg/kg of alfaxalone (MBA) in dogs anesthetized with sevoflurane. METHODS: Seven intact healthy Beagles (three males and four females, aged 3-6 years old and weighing 10.0-18.1 kg) anesthetized with a predetermined minimum alveolar concentration (MAC) of sevoflurane were included in this study. The baseline cardiorespiratory variable values were recorded using the thermodilution method with a pulmonary artery catheter after stabilization for 15 minutes at 1.3 times their individual sevoflurane MAC. The cardiorespiratory variables were measured again following the IM administration of MBA. Data are expressed as median [interquartile range] and compared with the corresponding baseline values using the Friedman test and Sheff's method. A p < 0.05 was considered statistically significant. RESULTS: The intramuscular administration of MBA transiently decreased the cardiac index [baseline: 3.46 (3.18-3.69), 5 minutes: 1.67 (1.57-1.75) l/minute/m2 : p < 0.001], respiratory frequency, and arterial pH. In contrast, it increased the systemic vascular resistance index [baseline: 5,367 (3,589-6,617), 5 minutes:10,197 (9,955-15,005) dynes second/cm5/m2 : p = 0.0092], mean pulmonary arterial pressure, and arterial partial pressure of carbon dioxide. CONCLUSION: The intramuscular administration of MBA in dogs anesthetized with sevoflurane transiently decreased cardiac output due to vasoconstriction. Although spontaneous breathing was maintained, MBA administration resulted in respiratory acidosis due to hypoventilation. Thus, it is important to administer MBA with caution to dogs with insufficient cardiovascular function. In addition, ventilatory support is recommended.
• Successful treatment of acute respiratory failure following hypertensive crisis in a dog with presumed pheochromocytoma or paraganglioma.
  Jun Tamura; Shino Yoshida; Noriyuki Nagata; Genya Shimbo; Norihiko Oyama
  Open veterinary journal, 13, 11, 1465, 1470, Nov. 2023, [International Magazine]
  English, BACKGROUND: Acute respiratory failure has been reported as one of the manifestations of hypertensive crisis in pheochromocytoma in human medicine. In dogs, no reports have been described as acute respiratory failure following hypertensive crisis. Here, we report the clinical presentation, course, and treatment of acute respiratory failure following the hypertensive crisis in a dog with presumed pheochromocytoma or paraganglioma. CASE DESCRIPTION: A 12-year-old neutered male toy poodle was referred for the diagnostic evaluation of a right adrenal gland mass. The dog suddenly exhibited severe dyspnea with abnormal hypertension (systolic blood pressure >200 mmHg) 15 minutes after recovery from the anesthesia for the computed tomography (CT) examination. Pulmonary CT and ultrasonography findings suggested acute onset of severe pulmonary edema. Pulmonary edema was treated with mechanical ventilation (pressure-support ventilation with continuous positive airway pressure) and negative fluid balance after the administration of furosemide. Weaning from mechanical ventilation was successful 24 hours after the onset of respiratory failure. Finally, the dog was discharged 3 days after weaning from ventilation without complications. CONCLUSION: This report outlines a case of acute respiratory failure following a hypertensive crisis requiring mechanical ventilatory management in a dog. The onset and progression of pulmonary edema were extremely rapid. However, improvement in pulmonary edema was also rapid. Hemodynamic stability, in addition to prompt diagnosis and aggressive therapeutic intervention, including mechanical ventilation, may have contributed to the good prognosis of pulmonary edema following hypertensive crisis in a dog, which we attribute to a catecholamine storm.
• 薬理作用から考える麻酔・疼痛管理法最終回 非ステロイド系抗炎症薬(NSAIDs)総論
  大山 紀彦; 山下 和人; 柴田 早苗; 齋藤 靖生; 鎌田 正利
  SURGEON, 27, 1, 70, 86, (株)エデュワードプレス, Jan. 2023
  Japanese
• 造影CT検査後に非心原性肺水腫を呈した褐色細胞腫を疑う犬の1例
  吉田 紫乃; 田村 純; 永田 矩之; 大山 紀彦; 新坊 弦也; 池中 良徳; 滝口 満喜
  北海道獣医師会雑誌, 66, 8, 289, 289, (公社)北海道獣医師会, Aug. 2022
  Japanese
• 麻酔中パルスオキシメーター測定異常から舌局所の灌流障害を疑った犬の1例
  田村 純; 湯本 優希; 大山 紀彦; 新坊 弦也; 滝口 満喜
  北海道獣医師会雑誌, 66, 8, 289, 289, (公社)北海道獣医師会, Aug. 2022
  Japanese
• 造影CT検査後に非心原性肺水腫を呈した褐色細胞腫を疑う犬の1例
  吉田 紫乃; 田村 純; 永田 矩之; 大山 紀彦; 新坊 弦也; 池中 良徳; 滝口 満喜
  北海道獣医師会雑誌, 66, 8, 289, 289, (公社)北海道獣医師会, Aug. 2022
  Japanese
• 麻酔中パルスオキシメーター測定異常から舌局所の灌流障害を疑った犬の1例
  田村 純; 湯本 優希; 大山 紀彦; 新坊 弦也; 滝口 満喜
  北海道獣医師会雑誌, 66, 8, 289, 289, (公社)北海道獣医師会, Aug. 2022
  Japanese
• Sparing effect of tramadol, lidocaine, dexmedetomidine and their combination on the minimum alveolar concentration of sevoflurane in dogs.
  Sayed Fathi El-Hawari; Norihiko Oyama; Yukako Koyama; Jun Tamura; Takaharu Itami; Tadashi Sano; Kazuto Yamashita
  Journal of veterinary science, 23, 4, e53, 09 May 2022, [International Magazine]
  English, Scientific journal, BACKGROUND: Problems associated with using inhalational anaesthesia are numerous in veterinary anaesthesia practice. Decreasing the amount of used inhalational anaesthetic agents and minimising of cardiorespiratory disorders are the standard goals of anaesthetists. OBJECTIVE: This experimental study was carried out to investigate the sparing effect of intravenous tramadol, lidocaine, dexmedetomidine and their combinations on the minimum alveolar concentration (MAC) of sevoflurane in healthy Beagle dogs. METHODS: This study was conducted on six beagle dogs. Sevoflurane MAC was determined by the tail clamp method on five separate occasions. The dogs received no treatment (control; CONT), tramadol (TRM: 1.5 mg kg-1 intravenously followed by 1.3 mg kg-1 h-1), lidocaine (LID: 2 mg kg-1 intravenously followed by 3 mg kg-1 h-1), dexmedetomidine (DEX: 2 μg kg-1 intravenously followed by 2 μg kg-1 h-1), and their combination (COMB), respectively. Cardiorespiratory variables were recorded every five minutes and immediately before the application of a noxious stimulus. RESULTS: The COMB treatment had the greatest sevoflurane MAC-sparing effect (67.4 ± 13.9%) compared with the other treatments (5.1 ± 25.3, 12.7 ± 14.3, and 40.3 ± 15.1% for TRM, LID, and DEX treatment, respectively). The cardiopulmonary variables remained within the clinically acceptable range following COMB treatment, although the mean arterial pressure was higher and accompanied by bradycardia. CONCLUSIONS: Tramadol-lidocaine-dexmedetomidine co-infusion produced a remarkable sevoflurane MAC-sparing effect in clinically healthy beagle dogs and could result in the alleviation of cardiorespiratory depression caused by sevoflurane. Cardiorespiratory variables should be monitored carefully to avoid undesirable side effects induced by dexmedetomidine.
• Unrecognized difficult airway management during anesthesia in two brachycephalic dogs with narrow cricoid cartilage.
  Jun Tamura; Norihiko Oyama; So Matsumoto; Ryo Owaki; Kenji Hosoya; Masahiro Okumura
  The Journal of veterinary medical science, 83, 2, 234, 240, 25 Feb. 2021, [Domestic magazines]
  English, Scientific journal, Difficulty in airway management during anesthesia was noted in a 10-year-old, castrated, male Pekingese dog and a 13-year-old male French Bulldog. They showed strong resistance during tracheal tube insertion through the subglottic lumen. Therefore, the airway was secured by using a small endotracheal tube or supraglottic airway device. Computed tomography scan revealed a markedly narrower vertical dimension of the cricoid cartilage compared to that seen in common brachycephalic breeds. Posterior glottis was relatively more accessible for translaryngeal intubation in the present cases. Our findings showed that brachycephalic airway syndrome may be associated with narrow cricoid cartilage. To the best of our knowledge, this is the first clinical case report of airway management during anesthesia in dogs with narrow cricoid cartilage.
• The anesthetic effects of intramuscular alfaxalone in dogs premedicated with low-dose medetomidine and/or butorphanol.
  Keiko Kato; Takaharu Itami; Ken Nomoto; Yusuke Endo; Jun Tamura; Norihiko Oyama; Tadashi Sano; Kazuto Yamashita
  The Journal of veterinary medical science, 83, 1, 53, 61, 14 Jan. 2021, [Domestic magazines]
  English, Scientific journal, We aimed to evaluate the induction, anesthesia, and cardiorespiratory effects of intramuscular (IM) anesthetic protocol with alfaxalone following premedication with low-dose medetomidine, butorphanol, or a combination of both (medetomidine-butorphanol) in dogs. Six healthy beagles were administered 1, 2.5, or 5 mg/kg alfaxalone IM following premedication with low-dose medetomidine (5 µg/kg; MA-IM), butorphanol (0.3 mg/kg; BA-IM), or medetomidine-butorphanol (5 µg/kg and 0.3 mg/kg, respectively; MBA-IM). Each dog received 9 treatments with minimum 7-day washout period between treatments. Dogs were allowed to breath room air during anesthetic induction. We attempted endotracheal intubation after alfaxalone administration. Alfaxalone produced a dose-dependent anesthetic effect in each anesthetic protocol. Intubation was achieved in 4 out of 6 dogs that received MA-IM and BA-IM with 2.5 mg/kg alfaxalone and in all dogs that received MBA-IM with 1, 2.5, and 5 mg/kg alfaxalone. The median durations [minimum-maximum] of accepting intubation were 79 [0-89], 97 [84-120], and 117 [84-217] min, respectively. Hypotension (mean arterial blood pressure <60 mmHg) did not develop, but bradycardia (heart rate <60 beats/min) was observed in all dogs that received the MA-IM and MBA-IM protocols. Severe hypoxemia (percutaneous arterial oxygen saturation <90%) developed in 2 dogs that received MBA-IM with 5 mg/kg alfaxalone. We consider that the MA-IM and BA-IM protocols with ≥2.5 mg/kg alfaxalone and the MBA-IM protocol with 1-2.5 mg/kg alfaxalone could provide clinically useful and effective anesthesia without causing severe cardiorespiratory depression in healthy dogs.
• Comparison of the anesthetic effects between 5 mg/kg of alfaxalone and 10 mg/kg of propofol administered intravenously in cats.
  Jun Tamura; Norihiko Oyama; Sho Fukui; Kazuto Yamashita
  The Journal of veterinary medical science, 83, 1, 73, 77, 14 Jan. 2021, [Domestic magazines]
  English, Scientific journal, To compare the anesthetic effects after intravenous administration of alfaxalone or propofol without premedication, either alfaxalone (5 mg/kg) or propofol (10 mg/kg) was administered intravenously over 120 sec in 6 cats. Each cat received the alternate treatment at least a 7-day interval. Anesthetic effects (tolerance of intubation, behavior changes and neurodepressive score) and physiological parameters were evaluated. Both treatments produced a rapid loss of consciousness, no apnea, and physiological parameters were maintained within clinically acceptable ranges apart from transient hypoxemia. The degree of hypoxemia was greater after the propofol treatment compared with the alfaxalone treatment. During the recovery period, more adverse events (ataxia, muscular tremors) were observed after the alfaxalone treatment compared with the propofol treatment.
• ST segment depression and ventricular fibrillation in a dog after contrast agent administration.
  Haruka Tamogi; Takaharu Itami; Ai Hori; Norihiko Oyama; Tadashi Sano; Kazuto Yamashita
  The Journal of veterinary medical science, 82, 11, 1714, 1718, 05 Dec. 2020, [Domestic magazines]
  English, Scientific journal, An 11-year-old Toy Poodle underwent a computed tomography examination with contrast (iohexol) enhancement under anesthesia. Heart rate and R-wave amplitude on electrocardiogram (ECG) increased 2.5 min after iohexol administration, and end-tidal carbon dioxide decreased to 12 mmHg. A progressive ST segment depression was observed on ECG. Subsequently, the ECG waveform changed to ventricular fibrillation. However, spontaneous circulation returned following cardiopulmonary resuscitation. Myocardial ischemia or anaphylactic shock was suspected in the dog, which explains the ST segment depression observed on ECG. When performing radiological examinations with a contrast agent, the ECG waveform changes, such as an increase in heart rate, R-wave amplitude, or ST segment depression, should be carefully monitored. This might enable early detection of cardiac dysfunction and the ensuing cardiac arrest in dogs.
• Surgical removal of cataract in an Asiatic black bear (Ursus thibetanus) by phacoemulsification and aspiration
  Seiya Maehara; Naoya Matsumoto; Naoaki Takiyama; Yoshiki Itoh; Yasunari Kitamura; Kazuto Yamashita; Tadashi Sano; Takaharu Itami; Norihiko Oyama; Miri Hayashi; Reiko Kato; Arisa Shimode; Arisa Masuko
  The Journal of veterinary medical science, 82, 6, 740, 744, 16 Jun. 2020, [Peer-reviewed]
  Scientific journal
• Surgical removal of cataract in an Asiatic black bear (Ursus thibetanus) by phacoemulsification and aspiration.
  Seiya Maehara; Naoya Matsumoto; Naoaki Takiyama; Yoshiki Itoh; Yasunari Kitamura; Kazuto Yamashita; Tadashi Sano; Takaharu Itami; Norihiko Oyama; Miri Hayashi; Reiko Kato; Arisa Shimode; Arisa Masuko
  The Journal of veterinary medical science, 82, 6, 740, 744, 16 Jun. 2020, [Peer-reviewed], [Domestic magazines]
  English, Scientific journal, A twenty-year-old male Asiatic black bear (Ursus thibetanus) presented at the Rakuno Gakuen University Animal Medical Center with a 10-year history of bilateral blindness and cataracts. Surgical treatment of bilateral cataracts by extracapsular lensextraction using phacoemulsification and aspiration (PEA) was performed under general anesthesia. An anterior capsulectomy was performed using micro iris scissors and micro anterior lens capsule forceps. The cataract was removed with PEA using the two-handed technique. After surgery, systemic corticosteroids, anti-inflammatory drugs and antibiotics were administered. After cataract removal, the bear had recovered vision, and good quality vision has been maintained to date (15 months). PEA can be a safe and effective treatment for cataracts that impair vision in bears.
• 造影剤投与後にST下降と心室細動を起こした犬の麻酔経験
  田面木 晴香; 伊丹 貴晴; 大山 紀彦; 加藤 桂子; 堀 あい; 石川 友駿; Wei Yixian; Chen I-Ying; 佐野 忠士; 山下 和人
  日本獣医麻酔外科学雑誌, 50, Suppl.2, 282, 282, (一社)日本獣医麻酔外科学会, Dec. 2019
  Japanese
• Sedative and physiological effects of low-dose intramuscular alfaxalone in rabbits.
  Ishikawa Y; Sakata H; Tachibana Y; Itami T; Oyama N; Umar MA; Sano T; Yamashita K
  The Journal of veterinary medical science, 81, 6, 851, 856, Jun. 2019, [Peer-reviewed], [Domestic magazines]
  English, Scientific journal, To evaluate sedative and physiological effects of low dose intramuscular (IM) alfaxalone, six healthy rabbits were administered single IM doses of alfaxalone at 1mg/kg (IM1), 2.5 mg/kg (IM2.5), or 5 mg/kg (IM5) with a minimum of 7-day washout period. Sedative effects were subjectively evaluated using a composite measure scoring system (maximum sedation score of 16) and pulse rate, respiratory rate, non-invasive blood pressure, and percutaneous oxygen-hemoglobin saturation were measured before and after IM alfaxalone. Loss of righting reflex (LRR) was achieved in all rabbits after IM2.5 and IM5 treatments but in only three rabbits after IM1 treatment. Median (interquartile range) times to LRR were 16 min (15-17), 6 min (6-6), and 4 min (4-4), and median durations of LRR were 0.5 min (0-7), 22.5 min (19-27), and 53 min (48-58) after IM1, IM2.5, and IM5 treatments, respectively. The duration of LRR after IM5 treatment was significantly longer than those after IM1and IM2.5 treatments (P<0.01). Median value of total sedation scores peaked at 10 min [score 3.5 (3-4)], from 10 min [score 13.5 (12-14)] to 15 min [score 13.5 (12-14)], and from 10 min [score 15 (12-15)] to 15 min [score 15 (14-15)] after IM1, IM2.5, and IM5 treatments, respectively. No rabbit showed circulatory depression and apnea although respiratory rate decreased after IM 2.5 and IM5 treatments. In conclusion, alfaxalone produced a dose-dependent sedative effect and a deep sedation was achieved by alfaxalone at 2.5 mg/kg IM in rabbits.
• Effect of sevoflurane anesthesia on neuromuscular blockade produced by rocuronium infusion in dogs.
  Sakata H; Ishikawa Y; Ishihara G; Oyama N; Itami T; Umar MA; Sano T; Yamashita K
  The Journal of veterinary medical science, 81, 3, 425, 433, Jan. 2019, [Peer-reviewed], [Domestic magazines]
  English, Scientific journal, This study evaluated the effect of sevoflurane anesthesia on neuromuscular blockade with rocuronium in dogs. Six healthy beagle dogs were anesthetized four times with a minimum 14-day washout period. On each occasion, the dogs were administered 1.25-, 1.5-, 1.75-, or 2.0-fold of the individualized minimum alveolar concentration (MAC) of sevoflurane and received an infusion of rocuronium (0.5 mg/kg followed by 0.2 mg/kg/hr) for 120 min. Neuromuscular function was monitored with acceleromyography and train-of-four (TOF) stimulation of the left hind limb. Time to achieve TOF count 0 (onset time), time from the onset of neuromuscular blockade to the reappearance of TOF count 4 (blockade period), and time from the onset of rocuronium infusion to attaining a 70 or 90% TOF ratio (TOFR70 or TOFR90) were recorded. There were no significant differences in the onset time, blockade period, and plasma rocuronium concentration between the sevoflurane MAC multiples. The TOFR70 and TOFR90 were dose-dependently prolonged with the sevoflurane MAC multiples. There were significant differences in the TOFR70 and TOFR90 between the 1.25 sevoflurane MAC (median: 55 and 77.5 min, respectively) and 1.75 sevoflurane MAC (122.0 and 122.6 min; P=0.020 and P=0.020, respectively), 1.25 sevoflurane MAC and 2.0 sevoflurane MAC (126.0 and 131.4 min; P=0.020 and P=0.020), and 1.5 sevoflurane MAC (97.5 and 121.3 min) and 2.0 sevoflurane MAC (P=0.033 and P=0.032). In dogs, sevoflurane anesthesia produced dose-dependent prolongation of recovery from neuromuscular blockade produced by rocuronium.
• Cardiovascular effects of intravenous colforsin in normal and acute respiratory acidosis canine models: A dose-response study.
  Itami T; Hanazono K; Oyama N; Sano T; Makita K; Yamashita K
  PloS one, 14, 7, e0213414, 2019, [Peer-reviewed], [International Magazine]
  English, Scientific journal, In acidosis, catecholamines are attenuated, and higher doses are often required to improve cardiovascular function. Colforsin activates adenylate cyclase in cardiomyocytes without beta-adrenoceptor. Here, six beagles were administered colforsin or dobutamine four times during eucapnia (partial pressure of arterial carbon dioxide 35-40 mm Hg; normal) and hypercapnia (ibid 90-110 mm Hg; acidosis) conditions. The latter was induced by CO2 inhalation. Anesthesia was induced with propofol and maintained with isoflurane. Cardiovascular function was measured by thermodilution and a Swan-Ganz catheter at baseline and 60 min after 0.3 μg/kg/min (low), 0.6 μg/kg/min (middle), and 1.2 μg/kg/min (high) colforsin administration. The median pH was 7.38 [range 7.33-7.42] and 7.01 [range 6.96-7.08] at baseline in the Normal and Acidosis conditions, respectively. Endogenous adrenaline and noradrenaline levels at baseline were significantly (P < 0.05) higher in the Acidosis than in the Normal condition. Colforsin induced cardiovascular effects similar to those caused by dobutamine. Colforsin increased cardiac output in the Normal condition (baseline: 3.9 ± 0.2 L/kg/m2 [mean ± standard error], low: 5.2 ± 0.4 L/kg/min2, middle: 7.0 ± 0.4 L/kg/m2, high: 9.4 ± 0.2 L/kg/m2; P < 0.001) and Acidosis condition (baseline: 6.1 ± 0.3 L/kg/m2, low: 6.2 ± 0.2 L/kg/m2, middle: 7.2 ± 0.2 L/kg/m2, high: 8.3 ± 0.2 L/kg/m2; P < 0.001). Colforsin significantly increased heart rate and decreased systemic vascular resistance compared to values at baseline. Both drugs increased pulmonary artery pressure, but colforsin (high: 13.3 ± 0.6 mmHg in Normal and 20.1 ± 0.2 mmHg in Acidosis) may have lower clinical impact on the pulmonary artery than dobutamine (high: 19.7 ± 0.6 in Normal and 26.7 ± 0.5 in Acidosis). Interaction between both drugs and experimental conditions was observed in terms of cardiovascular function, which were similarly attenuated with colforsin and dobutamine under acute respiratory acidosis.
• Influence of sevoflurane anesthesia with mechanical ventilation and fluid-therapy on distribution of subcutaneously administered robenacoxib in dogs.
  Oyama N; Sano T; Yamamori M; Tamura J; Umar MA; Endo Y; Ishikawa Y; Itoh A; Miyoshi K; Yamashita K
  The Journal of veterinary medical science, 80, 9, 1450, 1455, Aug. 2018, [Peer-reviewed], [Domestic magazines]
  English, Scientific journal, Robenacoxib is a novel nonsteroidal anti-inflammatory drug approved for dogs. The present study aimed to evaluate influences of sevoflurane anesthesia on the distribution of robenacoxib in dogs. Ten healthy beagle dogs (1 to 11 years old, 9.3 to 14.3 kg body weight, 6 males and 4 females) were subcutaneously administered robenacoxib (2 mg/kg) under conscious condition or sevoflurane anesthesia inhaled a 1.3-fold predetermined individual minimum alveolar concentration of sevoflurane at a 28-day interval. The dogs under sevoflurane anesthesia were also mechanically ventilated and received fluid-therapy. On each occasion, serum samples were collected from the dogs before and at 5, 15, 30, 60, 120, 180, and 240 min after the robenacoxib administration. Serum robenacoxib concentration was measured by a liquid chromatography-tandem mass spectrometry. Maximum serum concentration of robenacoxib (Cmax) was 2.2 µg/ml [range: 1.2-4.6] (median [range: minimum-maximum]) and time of Cmax (Tmax) was 90 min [range: 60-120] in the conscious dogs. In the sevoflurane-anesthetized dogs, the Cmax significantly declined (1.3 µg/ml [range: 0.8-1.4], P=0.008) and Tmax was delayed (120 min [range: 120-240], P=0.018) compared with those in the conscious dogs. The serum robenacoxib concentration at 240 min (C240) decreased to 0.5 µg/ml [range: 0.2-0.9] in the conscious dogs, while it remained higher in the sevoflurane-anesthetized dogs (1.0 µg/ml [range: 0.3-1.4], P=0.011). In conclusion, the anesthetic procedure with sevoflurane, mechanically ventilated, and received fluid-therapy might affect the pharmacokinetics of subcutaneously administered robenacoxib in dogs.
• Anesthetic and cardiorespiratory effects of single-bolus intravenous alfaxalone with or without intramuscular xylazine-premedication in calves.
  Sayed Fathi El-Hawari; Hisashi Sakata; Norihiko Oyama; Jun Tamura; Chika Higuchi; Yusuke Endo; Kenjirou Miyoshi; Tadashi Sano; Kazuyuki Suzuki; Kazuto Yamashita
  The Journal of veterinary medical science, 80, 2, 361, 367, 02 Mar. 2018, [Peer-reviewed], [Domestic magazines]
  English, Scientific journal, The anesthetic and cardiorespiratory effects of xylazine-alfaxalone combination were evaluated in calves. Six calves (age: 6-9 months old; weight: 114-310 kg) were anesthetized with intravenous alfaxalone 15 min after administration of intramuscular saline (0.5 ml/100 kg) or xylazine (0.1 mg/kg; 0.5 ml/100 kg of a 2% xylazine solution). Anesthesia induction was smooth and orotracheal intubation was achieved in all calves. The calves anesthetized with xylazine-alfaxalone required a smaller induction dose of alfaxalone (1.23 ± 0.17 mg/kg, P=0.010) and accepted endotracheal intubation for a significantly longer period (16.8 ± 7.2 min, P=0.022) than the calves anesthetized with alfaxalone alone (2.28 ± 0.65 mg/kg 7.3 ± 1.6 min). At 5 min after induction, tachycardia (heart rate: 166 ± 47 beats/min of heart rate), hypertension (mean arterial blood pressure: 147 ± 81 mmHg) and hypoxemia (partial pressure of arterial blood oxygen [PaO2]: 43 ± 10 mmHg) were observed in the calves anesthetized with alfaxalone alone, whereas hypoxemia (PaO2: 47 ± 7 mmHg) and mild hypercapnia (partial pressure of arterial blood carbon dioxide: 54 ± 5 mmHg) were observed in the calves anesthetized with xylazine-alfaxalone. Premedication with xylazine provided a sparing effect on the induction dose of alfaxalone and a prolongation of anesthetic effect. Oxygen supplementation should be considered to prevent hypoxemia during anesthesia.
• Interaction between maropitant and carprofen on sparing of the minimum alveolar concentration for blunting adrenergic response (MAC-BAR) of sevoflurane in dogs
  Sho Fukui; Norihiko Ooyama; Jun Tamura; Mohammed Ahmed Umar; Tomohito Ishizuka; Takaharu Itami; Kenjiro Miyoshi; Tadashi Sano; Kazuto Yamashita
  JOURNAL OF VETERINARY MEDICAL SCIENCE, 79, 3, 502, 508, Mar. 2017, [Peer-reviewed]
  English, Scientific journal
• Sedative effects of intramuscular alfaxalone administered to cats
  Jun Tamura; Tomohito Ishizuka; Sho Fukui; Norihiko Oyama; Kodai Kawase; Takaharu Itami; Kenjiro Miyoshi; Tadashi Sano; Kirby Pasloske; Kazuto Yamashita
  JOURNAL OF VETERINARY MEDICAL SCIENCE, 77, 8, 897, 904, Aug. 2015, [Peer-reviewed]
  English, Scientific journal
• The pharmacological effects of the anesthetic alfaxalone after intramuscular administration to dogs
  Jun Tamura; Tomohito Ishizuka; Sho Fukui; Norihiko Oyama; Kodai Kawase; Kenjiro Miyoshi; Tadashi Sano; Kirby Pasloske; Kazuto Yamashita
  JOURNAL OF VETERINARY MEDICAL SCIENCE, 77, 3, 289, 296, Mar. 2015, [Peer-reviewed]
  English, Scientific journal
• Sparing Effect of Robenacoxib on the Minimum Alveolar Concentration for Blunting Adrenergic Response (MAC-BAR) of Sevoflurane in Dogs
  Jun Tamura; Takaharu Itami; Tomohito Ishizuka; Sho Fukui; Norihiko Ooyama; Kenjiro Miyoshi; Tadashi Sano; Kazuto Yamashita
  JOURNAL OF VETERINARY MEDICAL SCIENCE, 76, 1, 113, 117, Jan. 2014, [Peer-reviewed]
  English, Scientific journal
• Clinical Evaluation of Intraoperative Multimodal Analgesia Using Constant Rate Infusion of Morphine-Lidocaine-Ketamine Drug Combination in Dogs Undergoing Hemilaminectomy
  ITAMI Takaharu; KUMAMOTO Natsuko; ISHIZUKA Tomohito; TAMURA Jun; FUKUI Sho; OYAMA Norihiko; KAWASE Kodai; MIYOSHI Kenjiro; SANO Tadashi; UENO Hiroshi; IZUMISAWA Yasuharu; YAMASHITA Kazuto
  The Japanese Journal of Veterinary Anesthesiology, 44, 3, 23, 30, Japanese Society of Veterinary Anesthesia & Surgery, 2013
  Japanese, Anesthetic and cardiorespiratory effects of nitrous oxide-oxygen-sevoflrane (GOS) anesthesia with or without a constant rate infusion (CRI) of morphine (0.2 mg/kg/hr) lidocaine (3 mg/kg/hr) and ketamine (0.6 mg/kg/hr) drug combination (MLK-CRI) were evaluated in 50 dogs undergoing hemilaminectomy. All dogs premedicated with an intravenous midazolam (0.3 mg/kg) and intramuscular morphine (0.3 mg/kg) and anesthetized with an intravenous propofol (6 mg/kg). Surgical depth of anesthesia was maintained by GOS with (n=25) or without (n=25) MLK-CRI. Total anesthesia time and extubation time were 83 ± 9 and 17 ± 12 minutes in dogs anesthetized with MLK-CRI or 105 ± 20 and 4 ± 3 minutes in dogs anesthetized without MLK-CRI. The end-tidal sevoflurane concentrations during surgery were 1.50–1.85% or 1.95–2.05% in dogs anesthetized by GOS with or without MLK-CRI, respectively. The sevoflurane requirements for maintaining surgical depth of anesthesia was reduced up to approximately 27% without severe cardiovascular suppression in the dogs receiving MLK-CRI. On the other hand, controlled ventilation was indispensable during anesthesia and extubation time was prolonged in the dogs receiving MLK-CRI. In conclusion, MLK-CRI is clinically useful for sparing with anesthetic requirement and preserving cardiac function during anesthesia, however, it should be aware of respiratory suppression and possibility of prolonged recovery in dogs receiving MLK-CRI.

• 胸腔鏡下結紮術を適用した先天性体肺動脈瘻の犬の1例
  細谷謙次; 細谷謙次; 丸子冬聖; 大山紀彦; 大脇稜; 川元誠; 木之下怜平; 金尚昊; 金尚昊; 奥村正裕, 日本獣医麻酔外科学会学術集会抄録集(CD-ROM), 110th, 2025
• 多波長生体電気インピーダンス法を用いた犬の体組成解析に関する基礎的研究
  田村純; 伊丹貴晴; 伊丹貴晴; 加藤桂子; 杉田千尋; 大山紀彦; 山下和人; 山下和人, 日本獣医麻酔外科学会学術集会抄録集(CD-ROM), 108th, 2024
• 犬における多波長生体電気インピーダンス法を用いた非侵襲的体組成解析の基礎的研究
  田村純; 伊丹貴晴; 伊丹貴晴; 加藤桂子; 杉田千尋; 大山紀彦; 山下和人; 山下和人, 日本獣医学会学術集会講演要旨集, 167th, 2024
• 犬猫におけるメデトミジン・ブトルファノール・アルファキサロン(MBA)の混合筋肉内投与を用いた麻酔導入法の臨床的検討
  加藤 桂子; 大山 紀彦; 伊丹 貴晴; 佐野 忠士; 山下 和人, 北海道獣医師会雑誌, 63, 8, 354, 354, Aug. 2019
  (公社)北海道獣医師会, Japanese
• 犬の内毒素血症モデルにおける輸液反応性指標としての動的指標の有用性
  高井健史郎; 韋懿仙; 伊丹貴晴; 大山紀彦; 佐野悠人; 佐野忠士; 佐野忠士; 山下和人; 山下和人, 日本獣医麻酔外科学雑誌(Web), 50, Supplement 1, 292, 05 Jun. 2019
  Japanese
• ウサギにおけるアルファキサロン経鼻投与の鎮静効果
  青木兼三; 石川友駿; 酒田尚志; 韋懿仙; 大山紀彦; 伊丹貴晴; 佐野忠士; 佐野忠士; 山下和人; 山下和人, 日本獣医麻酔外科学雑誌(Web), 50, Supplement 1, 277, 05 Jun. 2019
  Japanese
• ロクロニウムの末梢性筋弛緩作用に対するプロポフォールとの相互作用
  横田優真; 酒田尚志; 石川友駿; 韋懿仙; 大山紀彦; 伊丹貴晴; 佐野忠士; 佐野忠士; 山下和人; 山下和人, 日本獣医麻酔外科学雑誌(Web), 50, Supplement 1, 290, 05 Jun. 2019
  Japanese
• 犬の尾椎硬膜外麻酔における薬液伸展領域および知覚神経遮断領域の検討
  橋本雅之; 伊丹貴晴; 堀あい; 大山紀彦; 石川友駿; 韋懿仙; 佐野忠士; 佐野忠士; 山下和人; 山下和人, 日本獣医麻酔外科学雑誌(Web), 50, Supplement 1, 291, 05 Jun. 2019
  Japanese
• ウサギにおけるメデトミジン‐ブトルファノール‐アルファキサロン混合筋肉内投与による鎮静効果
  野淵朝香; 石川友駿; 酒田尚志; 韋懿仙; 大山紀彦; 伊丹貴晴; 佐野忠士; 佐野忠士; 山下和人; 山下和人, 日本獣医麻酔外科学雑誌(Web), 50, Supplement 1, 277, 05 Jun. 2019
  Japanese
• ウサギにおけるメデトミジン-ブトルファノール-アルファキサロン混合筋肉内投与による鎮静効果
  野淵 朝香; 石川 友駿; 酒田 尚志; 韋 懿仙; 大山 紀彦; 伊丹 貴晴; 佐野 忠士; 山下 和人, 日本獣医麻酔外科学雑誌, 50, Suppl.1, 277, 277, Jun. 2019
  (一社)日本獣医麻酔外科学会, Japanese
• ウサギにおけるアルファキサロン経鼻投与の鎮静効果
  青木 兼三; 石川 友駿; 酒田 尚志; 韋 懿仙; 大山 紀彦; 伊丹 貴晴; 佐野 忠士; 山下 和人, 日本獣医麻酔外科学雑誌, 50, Suppl.1, 277, 277, Jun. 2019
  (一社)日本獣医麻酔外科学会, Japanese
• ロクロニウムの末梢性筋弛緩作用に対するプロポフォールとの相互作用
  横田 優真; 酒田 尚志; 石川 友駿; 韋 懿仙; 大山 紀彦; 伊丹 貴晴; 佐野 忠士; 山下 和人, 日本獣医麻酔外科学雑誌, 50, Suppl.1, 290, 290, Jun. 2019
  (一社)日本獣医麻酔外科学会, Japanese
• 犬の尾椎硬膜外麻酔における薬液伸展領域および知覚神経遮断領域の検討
  橋本 雅之; 伊丹 貴晴; 堀 あい; 大山 紀彦; 石川 友駿; 韋 懿仙; 佐野 忠士; 山下 和人, 日本獣医麻酔外科学雑誌, 50, Suppl.1, 291, 291, Jun. 2019
  (一社)日本獣医麻酔外科学会, Japanese
• 犬の内毒素血症モデルにおける輸液反応性指標としての動的指標の有用性
  高井 健史郎; 韋 懿仙; 伊丹 貴晴; 大山 紀彦; 佐野 悠人; 佐野 忠士; 山下 和人, 日本獣医麻酔外科学雑誌, 50, Suppl.1, 292, 292, Jun. 2019
  (一社)日本獣医麻酔外科学会, Japanese
• 造影剤投与後にST下降と心室細動を起こした犬の麻酔経験
  田面木晴香; 伊丹貴晴; 大山紀彦; 加藤桂子; 堀あい; 石川友駿; WEI Yixian; CHEN I-Ying; 佐野忠士; 佐野忠士; 山下和人; 山下和人, 日本獣医麻酔外科学雑誌(Web), 50, Supplement 2, 2019
• ウサギにおける低用量アルファキサロン筋肉内投与による鎮静効果
  橘侑里; 石川友駿; 酒井尚志; 大山紀彦; 伊丹貴晴; 佐野忠士; 佐野忠士; 山下和人; 山下和人, 日本獣医麻酔外科学雑誌, 49, Supplement 1, 281, 281, 05 Jun. 2018
  (一社)日本獣医麻酔外科学会, Japanese
• 犬の重症心原性肺水腫10例における集中治療の概要と治療成績
  田面木晴香; 原田達彦; 田中翔; 伊藤暁史; 伊藤暁史; 川瀬広大; 大山紀彦; 大山紀彦; 伊丹貴晴; 伊丹貴晴; 佐野忠士; 佐野忠士; 山下和人; 山下和人, 日本獣医麻酔外科学雑誌, 49, Supplement 1, 279, 279, 05 Jun. 2018
  (一社)日本獣医麻酔外科学会, Japanese
• 犬におけるロクロニウムの筋弛緩作用へのセボフルランとプロポフォールの相互作用の比較
  粥川春花; 酒田尚志; 石川友駿; 大山紀彦; 伊丹貴晴; 佐野忠士; 佐野忠士; 山下和人; 山下和人, 日本獣医麻酔外科学雑誌, 49, Supplement 1, 279, 279, 05 Jun. 2018
  (一社)日本獣医麻酔外科学会, Japanese
• トラマドール‐デクスメデトミジン‐リドカインによる犬のセボフルラン最小肺胞濃度の減少効果
  小山由佳子; 酒田尚志; 石川友駿; 大山紀彦; 伊丹貴晴; 佐野忠士; 佐野忠士; 山下和人; 山下和人, 日本獣医麻酔外科学雑誌, 49, Supplement 1, 280, 280, 05 Jun. 2018
  (一社)日本獣医麻酔外科学会, Japanese
• レミフェンタニル‐低用量フェンタニルとプロポフォールまたはアルファキサロンを用いた犬の全静脈麻酔法の臨床的比較
  廣世有希; 伊藤暁史; 伊藤暁史; 田中翔; 原田達彦; 大山紀彦; 大山紀彦; 伊丹貴晴; 伊丹貴晴; 佐野忠士; 佐野忠士; 山下和人; 山下和人, 日本獣医麻酔外科学雑誌, 49, Supplement 1, 280, 280, 05 Jun. 2018
  (一社)日本獣医麻酔外科学会, Japanese
• 犬におけるロベナコキシブの薬物動態に対するセボフルラン吸入麻酔の影響
  山森瑞紀; 大山紀彦; 伊藤暁史; 三好健二郎; 佐野忠士; 山下和人, 日本獣医麻酔外科学雑誌, 47, Supplement 1, 281, 281, 05 Jun. 2016
  (一社)日本獣医麻酔外科学会, Japanese
• セボフルラン麻酔下の犬における脳波図の加齢に伴う変化
  樋口千佳; 春名太一; 萩平哲; 田村純; 福井翔; 大山紀彦; 川瀬広大; 遠藤雄介; 三好健二郎; 佐野忠士; 山下和人, 日本獣医麻酔外科学雑誌, 46, Supplement 2, 225, 225, 05 Dec. 2015
  (一社)日本獣医麻酔外科学会, Japanese
• 犬のアルファキサロン筋肉内麻酔導入における低用量メデトミジン麻酔前投薬の影響
  野本賢; 田村純; 遠藤雄介; 大山紀彦; 川瀬広大; 樋口千佳; 福井翔; 三好健二郎; 佐野忠士; 山下和人, 日本獣医麻酔外科学雑誌, 46, Supplement 1, 263, 263, 10 Jun. 2015
  (一社)日本獣医麻酔外科学会, Japanese
• 犬のセボフルラン麻酔中の脳波図におけるBurst suppressionに関する新たな基準
  樋口千佳; 春名太一; 萩平哲; 田村純; 福井翔; 大山紀彦; 川瀬広大; 遠藤雄介; 三好健二郎; 佐野忠士; 山下和人, 日本獣医麻酔外科学雑誌, 46, Supplement 1, 263, 263, 10 Jun. 2015
  (一社)日本獣医麻酔外科学会, Japanese
• 猫のアルファキサロン筋肉内麻酔導入に対する低用量メデトミジン麻酔前投薬の影響
  篠崎春香; 田村純; 遠藤雄介; 大山紀彦; 川瀬広大; 樋口千佳; 福井翔; 三好健二郎; 佐野忠士; 山下和人, 日本獣医麻酔外科学雑誌, 46, Supplement 1, 262, 262, 10 Jun. 2015
  (一社)日本獣医麻酔外科学会, Japanese
• 犬臨床例におけるアルファキサロンとプロポフォールの静脈内投与による麻酔導入の効果の比較
  菅原芽伊; 田村純; 遠藤雄介; 川瀬広大; 福井翔; 大山紀彦; 樋口千佳; 佐野忠士; 三好健二郎; 山下和人, 日本獣医麻酔外科学雑誌, 46, Supplement 1, 261, 261, 10 Jun. 2015
  (一社)日本獣医麻酔外科学会, Japanese
• 犬における外科手術の内容と術後疼痛の程度
  並木祐宜; 田村純; 遠藤雄介; 樋口千佳; 福井翔; 大山紀彦; 川瀬広大; 三好健二郎; 佐野忠士; 山下和人, 日本獣医麻酔外科学雑誌, 46, Supplement 1, 266, 266, 10 Jun. 2015
  (一社)日本獣医麻酔外科学会, Japanese
• 犬における非侵襲的輸液反応性指標としてのPleth Variability Index(PVI)の有用性
  弘川拓; 田村純; 福井翔; 大山紀彦; 川瀬広大; 遠藤雄介; 樋口千佳; 三好健二郎; 佐野忠士; 山下和人, 日本獣医麻酔外科学雑誌, 46, Supplement 1, 265, 265, 10 Jun. 2015
  (一社)日本獣医麻酔外科学会, Japanese
• 犬のセボフルラン吸入麻酔における麻酔深度と脳波波形の変化
  樋口千佳; 春名太一; 萩平哲; 盛永恵香; 田村純; 福井翔; 大山紀彦; 川瀬広大; 遠藤雄介; 三好健二郎; 佐野忠士; 山下和人, 獣医麻酔外科学雑誌, 45, Supplement 2, 206, 206, 05 Dec. 2014
  (一社)日本獣医麻酔外科学会, Japanese
• 犬猫の臨床例の麻酔導入におけるアルファキサロンの要求量
  安田知世; 田村純; 福井翔; 大山紀彦; 川瀬広大; 三好健二郎; 佐野忠士; 山下和人, 北海道獣医師会雑誌, 58, 8, 360, 360, 10 Aug. 2014
  (公社)北海道獣医師会, Japanese
• 犬におけるアルファキサロンとプロポフォールの麻酔導入効果の比較
  山本拓也; 田村純; 石塚友人; 福井翔; 大山紀彦; 川瀬広大; 遠藤雄介; 樋口千佳; 三好健二郎; 佐野忠士; 山下和人, 獣医麻酔外科学雑誌, 45, Supplement 1, 211, 211, 10 Jun. 2014
  (一社)日本獣医麻酔外科学会, Japanese
• 猫におけるアルファキサロンとプロポフォールの麻酔効果の比較
  福留希慧; 田村純; 石塚友人; 福井翔; 大山紀彦; 川瀬広大; 遠藤雄介; 樋口千佳; 三好健二郎; 佐野忠士; 山下和人, 獣医麻酔外科学雑誌, 45, Supplement 1, 210, 210, 10 Jun. 2014
  (一社)日本獣医麻酔外科学会, Japanese
• マロピタントとカルプロフェンの併用投与が犬のセボフルランMAC‐BARに及ぼす影響
  堀江眞季; 福井翔; 田村純; 石塚友人; 伊丹貴晴; 大山紀彦; 川瀬広大; 遠藤雄介; 樋口千佳; 三好健二郎; 佐野忠士; 山下和人, 獣医麻酔外科学雑誌, 45, Supplement 1, 234, 234, 10 Jun. 2014
  (一社)日本獣医麻酔外科学会, Japanese
• 酪農学園大学附属動物病院麻酔科における犬猫の麻酔関連偶発死亡例
  仙波惠張; 田村純; 石塚友人; 伊丹貴晴; 福井翔; 大山紀彦; 川瀬広大; 遠藤雄介; 樋口千佳; 三好健二郎; 佐野忠士; 山下和人, 獣医麻酔外科学雑誌, 45, Supplement 1, 236, 236, 10 Jun. 2014
  (一社)日本獣医麻酔外科学会, Japanese
• 犬臨床麻酔例の麻酔導入におけるアルファキサロンとプロポフォールの比較
  松本恵里香; 田村純; 石塚友人; 福井翔; 大山紀彦; 川瀬広大; 遠藤雄介; 樋口千佳; 三好健二郎; 佐野忠士; 山下和人, 獣医麻酔外科学雑誌, 45, Supplement 1, 211, 211, 10 Jun. 2014
  (一社)日本獣医麻酔外科学会, Japanese
• メデトミジン‐ブトルファノール‐アルファキサロン混合筋肉内投与による犬の注射麻酔法の検討
  田村純; 畠山直大; 石塚友人; 伊丹貴晴; 福井翔; 大山紀彦; 川瀬広大; 遠藤雄介; 樋口千佳; 三好健二郎; 佐野忠士; 山下和人, 獣医麻酔外科学雑誌, 45, Supplement 1, 199, 199, 10 Jun. 2014
  (一社)日本獣医麻酔外科学会, Japanese
• アルファキサロン筋肉内投与による猫の鎮静法の検討
  田村純; 石塚友人; 伊丹貴晴; 福井翔; 大山紀彦; 川瀬広大; 三好健二郎; 佐野忠士; 山下和人, 獣医麻酔外科学雑誌, 44, Supplement 2, 223, 223, 20 Dec. 2013
  (一社)日本獣医麻酔外科学会, Japanese
• 犬の外科手術症例における術前の静脈血血液ガス分析および血中乳酸濃度
  酒田尚志; 田村純; 石塚友人; 福井翔; 大山紀彦; 川瀬広大; 伊丹貴晴; 三好健二郎; 佐野忠士; 山下和人, 獣医麻酔外科学雑誌, 44, Supplement 1, 213, 213, 10 Jun. 2013
  (一社)日本獣医麻酔外科学会, Japanese
• メデトミジン‐リドカイン‐ブトルファノール‐プロポフォールを用いた馬の全静脈麻酔法の臨床応用
  野田龍介; 石塚友人; 田村純; 福井翔; 大山紀彦; 川瀬広大; 伊丹貴晴; 三好健二郎; 佐野忠士; 山下和人, 獣医麻酔外科学雑誌, 44, Supplement 1, 221, 221, 10 Jun. 2013
  (一社)日本獣医麻酔外科学会, Japanese
• 猫は小さな犬ではなかった!~猫におけるセボフルランのMACとMAC‐BAR~
  明石尚子; 田村純; 石塚友人; 福井翔; 大山紀彦; 川瀬広大; 伊丹貴晴; 三好健二郎; 佐野忠士; 山下和人, 獣医麻酔外科学雑誌, 44, Supplement 1, 222, 222, 10 Jun. 2013
  (一社)日本獣医麻酔外科学会, Japanese
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