Researcher Database

Takashi Tateno
Faculty of Information Science and Technology Bioengineering and Bioinformatics Bioengineering
Professor

Researcher Profile and Settings

Affiliation

  • Faculty of Information Science and Technology Bioengineering and Bioinformatics Bioengineering

Job Title

  • Professor

URL

Research funding number

  • 00314401

J-Global ID

Research Interests

  • 動的安定性   多電極アレイ   高頻度発火   信号検出   ダイナミッククランプ法   背景雑音   神経細胞   神経回路網   多点計測システム   神経科学   聴覚野   ハイブリッドシステム   電気生理学   神経モデル   大脳皮質神経細胞   ランダムダイナミカルシステム   聴覚系   

Research Areas

  • Life sciences / Biomaterials
  • Life sciences / Biomedical engineering
  • Informatics / Intelligent informatics
  • Informatics / Biological, health, and medical informatics

Academic & Professional Experience

  • 2011 - Today Hokkaido University Graduate School of Information Science and Technology
  • 2011 - 2011 Osaka University Graduate School of Frontier Biosciences

Education

  • 1992/04 - 1994/03  Osaka University  Graduate School of Engineering Science
  • 1990/04 - 1992/03  Osaka University  School of Engineering Science Direct Affiliates

Association Memberships

  • 日本数理生物学会   Society for Neuroscience   日本神経科学会   THE INSTITUTE OF ELECTRONICS, INFORMATION AND COMMUNICATION ENGINEERS.   日本神経回路学会   THE INSTITUTE OF ELECTRICAL ENGINEERS OF JAPAN   

Research Activities

Published Papers

  • Laminar Responses in the Auditory Cortex Using a Multielectrode Array Substrate for Simultaneous Stimulation and Recording
    Sota Takahashi, Shuto Muramatsu, Jun Nishikawa, Kazuo Satoh, Shuichi Murakami, Takashi Tateno
    (in press) 2019/01 [Refereed][Not invited]
  • 総説: 聴覚神経活動動態の計測と制御 ―神経制御工学の展開―
    舘野高
    生物物理 58 (3) 139 - 143 2018/06 [Refereed][Invited]
  • Hisayuki Osanai, Shunsuke Minusa, Takashi Tateno
    Neuroscience 371 346 - 370 1873-7544 2018/02/10 [Refereed][Not invited]
     
    Magnetic stimulation is widely used in neuroscience research and clinical treatment. Despite recent progress in understanding the neural modulation mechanism of conventional magnetic stimulation methods, the physiological mechanism at the cortical microcircuit level is not well understood due to the poor stimulation focality and large electric artifact in the recording. To overcome these issues, we used a sub-millimeter-sized coil (micro-coil) to stimulate the mouse auditory cortex in vivo. To determine the mechanism, we conducted the first direct electrophysiological recording of micro-coil-driven neural responses at multiple sites on the horizontal surface and laminar areas of the auditory cortex. The laminar responses of local field potentials (LFPs) to the magnetic stimulation reached layer 6, and the spatiotemporal profiles were very similar to those of the acoustic stimulation, suggesting the activation of the same cortical microcircuit. The horizontal LFP responses to the magnetic stimulation were evoked within a millimeter-wide area around the stimulation coil. The activated cortical area was dependent on the coil orientation, providing useful information on the effective position of the coil relative to the brain surface for modulating cortical circuitry activity. In addition, numerical calculation of the induced electric field in the brain revealed that the inhomogeneity of the horizontal electric field to the surface is critical for micro-coil-induced cortical activation. The results suggest that our micro-coil technique has the potential to be used as a chronic, less-invasive and highly focal neuro-stimulator, and is useful for investigating microcircuit responses to magnetic stimulation for clinical treatment.
  • Jun Nishikawa, Yuto Ohtaka, Yuishi Tachibana, Yasutaka Yanagawa, Hisayuki Osanai, Takeaki Haga, Takashi Tateno
    Journal of Neuroscience Methods 293 77 - 85 1872-678X 2018/01/01 [Refereed][Not invited]
     
    Background Chronic neural recording in freely moving animals is important for understanding neural activities of cortical neurons associated with various behavioral contexts. In small animals such as mice, it has been difficult to implant recording electrodes into exact locations according to stereotactic coordinates, skull geometry, or the shape of blood vessels. The main reason for this difficulty is large individual differences in the exact location of the targeted brain area. New methods We propose a new electrode implantation procedure that is combined with transcranial flavoprotein fluorescence imaging. We demonstrate the effectiveness of this method in the auditory cortex (AC) of mice. Results Prior to electrode implantation, we executed transcranial flavoprotein fluorescence imaging in anesthetized mice and identified the exact location of AC subfields through the skull in each animal. Next, we surgically implanted a microdrive with a tungsten electrode into exactly the identified location. Finally, we recorded neural activity in freely moving conditions and evaluated the success rate of recording auditory responses. Comparison with existing method(s) These procedures dramatically improved the success rate of recording auditory responses from 21.1% without imaging to 100.0% with imaging. We also identified large individual differences in positional relationships between sound-driven response areas and the squamosal suture or blood vessels. Conclusions Combining chronic electrophysiology with transcranial flavoprotein fluorescence imaging before implantation enables the realization of reliable subfield-targeted neural recording from freely moving small animals.
  • Minoru Namikawa, Ayaka Sano, Takashi Tateno
    FRONTIERS IN AGING NEUROSCIENCE 9 395  1663-4365 2017/12 [Refereed][Not invited]
     
    The prevalence of tinnitus is known to increase with age. The age-dependent mechanisms of tinnitus may have important implications for the development of new therapeutic treatments. High doses of salicylate can be used experimentally to induce transient tinnitus and hearing loss. Although accumulating evidence indicates that salicylate induces tinnitus by directly targeting neurons in the peripheral and central auditory systems, the precise effect of salicylate on neural networks in the auditory cortex (AC) is unknown. Here, we examined salicylate-induced changes in stimulus-driven laminar responses of AC slices with salicylate superfusion in young and aged senescence-accelerated-prone (SAMP) and -resistant (SAMR) mice. Of the two strains, SAMP1 is known to be a more suitable model of presbycusis. We recorded stimulus-driven laminar local field potential (LFP) responses at multi sites in AC slice preparations. We found that for all AC slices in the two strains, salicylate always reduced stimulus-driven LFP responses in all layers. However, for the amplitudes of the LFP responses, the two senescence-accelerated mice (SAM) strains showed different laminar properties between the pre-and post-salicylate conditions, reflecting strainrelated differences in local circuits. As for the relationships between auditory brainstem response (ABR) thresholds and the LFP amplitude ratios in the pre-vs. post-salicylate condition, we found negative correlations in layers 2/ 3 and 4 for both older strains, and in layer 5 (L5) in older SAMR1. In contrast, the GABAergic agonist muscimol (MSC) led to positive correlations between ABR thresholds and LFP amplitude ratios in the prevs. post-MSC condition in younger SAM mice from both strains. Further, in younger mice, salicylate decreased the firing rate in AC L4 pyramidal neurons. Thus, salicylate can directly reduce neural excitability of L4 pyramidal neurons and thereby influence AC neural circuit activity. That we observed age-dependent effects of salicylate and varied GABAergic sensitivity in the AC among mouse strains with hearing loss implies that potential therapeutic mechanisms for tinnitus may operate differently in young vs. aged subjects. Therefore, scientists developing new therapeutic modalities for tinnitus treatment should consider using both aged and young animals.
  • Minusa S, Osanai H, Tateno T
    IEEE transactions on bio-medical engineering 0018-9294 2017/09 [Refereed][Not invited]
  • Yasutaka Yanagawa, Kengo Takasu, Hisayuki Osanai, Takashi Tateno
    HEARING RESEARCH 351 98 - 115 0378-5955 2017/08 [Refereed][Not invited]
     
    Salicylate is the active ingredient in aspirin, and in high-doses it is used as an experimental tool to induce transient hearing loss, tinnitus, and hyperacusis. These salicylate-induced perceptual disturbances are associated with tonotopic-map reorganization and neural activity modulation, and such neural correlates have been examined in the central auditory pathway, including the auditory cortex (AC). Although previous studies have reported that salicylate induces increases in noise-burst-evoked neural responses and reorganization of tonotopic maps in the primary AC, little is known about the effects of salicylate on other frequency-organized AC subfields such as the anterior auditory, secondary auditory, and dorsomedial fields. Therefore, to examine salicylate-induced spatiotemporal effects on AC subfields, we measured sound-evoked neural activity in mice before and after the administration of sodium salicylate (SS, 200 mg/kg), using flavoprotein auto-fluorescence imaging. SS-treatment gradually reduced responses driven by tone-bursts with lower (<= 8 kHz) and higher (>= 25 kHz) frequencies over 3 h, whereas evoked responses to tone-bursts within middle-range frequencies (e.g., 12 and 16 kHz) were sustained and unchanged in the four subfields. Additionally, in each of the four subfields, SS-treatment induced similar reorganization of tonotopic maps, and the response areas selectively driven by the middle-range frequencies were profoundly expanded. Our results indicate that the SS-induced tonotopic map reorganizations in each of the four AC subfields were similar, and only the extent of the activated areas responsive to tone-bursts with specific frequencies was subfield-dependent. Thus, we expect that examining cortical reorganization induced by SS may open the possibility of new treatments aimed at altering cortical reorganization into the normative functional organization. (C) 2017 Elsevier B.V. All rights reserved.
  • Daiki Yamamura, Takashi Tateno
    IEEJ TRANSACTIONS ON ELECTRICAL AND ELECTRONIC ENGINEERING 12 S164 - S170 1931-4973 2017/06 [Refereed][Not invited]
     
    All sensory cortical areas, including the auditory cortex, are considered to be wired according to the same general laminar structure schema, commonly referred to as the canonical model of cortical circuitry. The auditory cortex in vivo, however, is functionally anisotropic; the functional organization along the tonotopic axis is qualitatively different from that orthogonal to this axis. In the current study, we examined whether the functional anisotropy of the auditory cortex observed in vivo is reflected in propagation activity driven by electric stimulation in the local microcircuitry in vitro. Using in vitro preparations of coronal and angled horizontal brain slices, we directly investigated their isotropic versus anisotropic properties using microstimulation and multi-site recording with a multielectrode array substrate. Our results clearly demonstrated the isotropic properties of the circuits in slice preparations of the auditory cortex. Additionally, we found that driven by stimulation current in layer 4, the horizontal velocity of activity propagation in layer 2/3 was faster than the vertical velocity from layer 4 to layer 2/3 and the horizontal velocity in layer 4. On the basis of these results, we discuss the local network and its possible functions in the auditory cortex. (C) 2017 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.
  • Daiki Yamamura, Ayaka Sano, Takashi Tateno
    BRAIN RESEARCH 1659 96 - 112 0006-8993 2017/03 [Refereed][Not invited]
     
    To examine local network properties of the mouse auditory cortex in vitro, we recorded extracellular spatiotemporal laminar profiles driven by short electric local stimulation on a planar multielectrode array substrate. The recorded local field potentials were subsequently evaluated using current source density (CSD) analysis to identify sources and sinks. Current sinks are thought to be an indicator of net synaptic current in the small volume of cortex surrounding the recording site. Thus, CSD analysis combined with multielectrode arrays enabled us to compare mean synaptic activity in response to small current stimuli on a layer-by-layer basis. We also used senescence-accelerated mice (SAM), some strains of which show earlier onset of age-related hearing loss, to examine the characteristic spatiotemporal CSD profiles stimulated by electrodes in specific cortical layers. Thus, the CSD patterns were classified into several clusters based on stimulation sites in the cortical layers. We also found some differences in CSD patterns between the two SAM strains in terms of aging according to principle component analysis with dimension reduction. For simultaneous two-site stimulation, we modeled the obtained CSD profiles as a linear superposition of the CSD profiles to individual single-site stimulation. The model analysis indicated the nonlinearity of spatiotemporal integration over stimulus-driven activity in a layer-specific manner. Finally, on the basis of these results, we discuss the auditory cortex local network properties and the effects of aging on these mouse strains. (C) 2017 Elsevier B.V. All rights reserved.
  • Yasutaka Yanagawa, Hisayuki Osanai, Takashi Tateno
    NEUROSCIENCE LETTERS 633 189 - 195 0304-3940 2016/10 [Refereed][Not invited]
     
    The effects of anesthesia on the functional auditory characteristics of cortical neurons, such as spatial and temporal response properties, vary between an anesthetized and an awake subject. However, studies have shown that an appropriate anesthetic method that approaches the awake condition is still useful because of its greater stability and controllability. The present study compared neural response properties from two core fields of the mouse auditory cortex under three anesthetic conditions: urethane; ketamine and xylazine hydrochloride (KX) mixture; and a combination of medetomidine, midazolam, and butorphanol (MMB). To measure sound stimulation in vivo, we recorded flavoprotein-autofluorescent images of endogenous green fluorescence. Under all conditions, fluorescence changes in auditory core subfields in response to tones were observed, and response properties, such as peak intensity, latency, duration, and activated areas were analyzed. Results showed larger response peak intensity, latency, and duration in the core subfields under urethane compared with KX and MMB, with no significant differences between KX and MMB. Conversely, under KX anesthesia the activated areas showed characteristic response properties in a subfield-dependent manner. These results demonstrated the varied effects of anesthesia on response properties in the core subfields of the auditory cortex. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
  • Hisayuki Osanai, Takashi Tateno
    HEARING RESEARCH 339 69 - 79 0378-5955 2016/09 [Refereed][Not invited]
     
    Anesthesia affects central auditory processing. However, it is unclear to what extent the choice of anesthetic agent affects neural responses to sound stimulation. A mixture of three anesthetics (medetomidine, midazolam and butorphanol; MMB) was recently developed as an alternative to lcetamine owing to the latter's addictive potential, yet the effect of this combination of anesthetics on neural responses is not known. Here, we compared the spontaneous activity, tuning properties and temporal responses of primary auditory cortical neurons under these two anesthetic conditions, using electro-physiological and flavoprotein autofluorescence imaging methods. Frequency tuning properties were not significantly different between ketamine and MMB anesthesia. However, neural activity under MMB showed decreases in the spontaneous and tone-evoked firing rates in a layer-dependent manner. Moreover, the temporal response patterns were also different between the anesthetics in a layer dependent manner, which may reflect differences in the anesthetic mechanisms. These results demonstrated how response properties in the primary auditory cortex are affected by the choice of anesthesia. (C) 2016 Elsevier B.V. All rights reserved.
  • Osanai, Hisayuki, Tateno, Takashi
    NEURAL INFORMATION PROCESSING, ICONIP 2016, PT II 9948 363 - 371 0302-9743 2016 [Refereed][Not invited]
     
    Neural oscillations are considered to reflect the activity of neural populations, and are thus closely associated with brain function. However, the extent to which different anesthetic agents exert unique effects on such oscillations is unclear. A mixture of three anesthetics (medetomidine, midazolam, and butorphanol) was recently developed as an alternative to ketamine, which has potential addictive effects. Yet, little is known about the effects of this combination of anesthetics on neural oscillations. In this study, we used multi-channel electro-physiological recording and flavoprotein endogenous imaging to compare sound-driven oscillations in primary auditory cortical neurons after administration of ketamine vs. a medetomidine, midazolam, and butorphanol mixture. We observed differences in high gamma activities (over 120 Hz) between these two anesthetics, independent of cortical layers, but found no differences in activities including lower frequency components (<120 Hz). Our results provide new information about how specific anesthetics influence sound-driven neural oscillations.
  • Shunsuke Minusa, Takashi Tateno
    NEURAL INFORMATION PROCESSING, ICONIP 2016, PT II 9948 372 - 380 0302-9743 2016 [Refereed][Not invited]
     
    Although electromagnetic stimulation is widely used in neurological studies and clinical applications, conventional electromagnetic stimulation methods have several limitations. Recent studies have reported that micro magnetic stimulation (mu MS), which can directly activate neural tissue and cells via sub-millimeter solenoids, has the possibility to overcome such limitations. However, the development and application of mu MS using implantable sub-millimeter solenoids has not yet been reported. Here, we proposed a new implantable mu MS system and evaluated its validity. In particular, using flavoprotein fluorescence imaging with a high spatial resolution, we evaluated if the stimuli delivered by our system were large enough to activate the mouse auditory cortex in vivo. The results indicated that our system successfully activated neural tissue, and the activity propagation was observed on the brain surface. Thus, this study is the first step to applying mu MS implantable devices in investigating basic neuroscience and clinical application tools.
  • Daiki Yamamura, Sano Ayaka, Takashi Tateno
    NEURAL INFORMATION PROCESSING, ICONIP 2016, PT II 9948 353 - 362 0302-9743 2016 [Refereed][Not invited]
     
    To examine microcircuit properties of the mouse auditory cortex (AC) in vitro, we extracellularly recorded spatiotemporal laminar profiles driven by short electric microstimulation on a planar multielectrode array (MEA) substrate. The recorded local field potentials (LFPs) were subsequently evaluated using current source density (CSD) analysis to identify sources and sinks. Current sinks are thought to be an indicator of net synaptic current in a small volume of cortex surrounding the recording site. Thus, CSD analysis combined with MEAs enabled us to compare mean synaptic activity in response to current stimuli on a layer-bylayer basis. Here, we used senescence-accelerated mice (SAM), some strains of which show age-related hearing loss, to examine characteristic spatiotemporal CSD patterns stimulated by electrodes in specific cortical layers. Thus, the CSD patterns were classified into several clusters based on the stimulation sites in the cortical layers. We also found, in a reduced space obtained by principle component analysis, some CSD pattern differences between the two SAM strains in terms of aging and stimulation layers. Finally, on the basis of these results, we discuss the effects of aging on AC microcircuit properties.
  • Takashi Tateno, Jun Nishikawa
    Frontiers in Neuroengineering 7 39  1662-6443 2014/10/10 [Refereed][Not invited]
     
    In this report, we describe the system integration of a complementary metal oxide semiconductor (CMOS) integrated circuit (IC) chip, capable of both stimulation and recording of neurons or neural tissues, to investigate electrical signal propagation within cellular networks in vitro. The overall system consisted of three major subunits: a 5.0 × 5.0 mm CMOS IC chip, a reconfigurable logic device (field-programmable gate array, FPGA), and a PC. To test the system, microelectrode arrays (MEAs) were used to extracellularly measure the activity of cultured rat cortical neurons and mouse cortical slices. The MEA had 64 bidirectional (stimulation and recording) electrodes. In addition, the CMOS IC chip was equipped with dedicated analog filters, amplification stages, and a stimulation buffer. Signals from the electrodes were sampled at 15.6 kHz with 16-bit resolution. The measured input-referred circuitry noise was 10.1 μ V root mean square (10 Hz to 100 kHz), which allowed reliable detection of neural signals ranging from several millivolts down to approximately 33 μ Vpp. Experiments were performed involving the stimulation of neurons with several spatiotemporal patterns and the recording of the triggered activity. An advantage over current MEAs, as demonstrated by our experiments, includes the ability to stimulate (voltage stimulation, 5-bit resolution) spatiotemporal patterns in arbitrary subsets of electrodes. Furthermore, the fast stimulation reset mechanism allowed us to record neuronal signals from a stimulating electrode around 3 ms after stimulation. We demonstrate that the system can be directly applied to, for example, auditory neural prostheses in conjunction with an acoustic sensor and a sound processing system.
  • Takashi Tateno, Jun Nishikawa, Nobuyoshi Tsuchioka, Hirofumi Shintaku, Satoyuki Kawano
    Frontiers in neuroengineering 6 12 - 12 2013 [Refereed][Not invited]
     
    To improve the performance of cochlear implants, we have integrated a microdevice into a model of the auditory periphery with the goal of creating a microprocessor. We constructed an artificial peripheral auditory system using a hybrid model in which polyvinylidene difluoride was used as a piezoelectric sensor to convert mechanical stimuli into electric signals. To produce frequency selectivity, the slit on a stainless steel base plate was designed such that the local resonance frequency of the membrane over the slit reflected the transfer function. In the acoustic sensor, electric signals were generated based on the piezoelectric effect from local stress in the membrane. The electrodes on the resonating plate produced relatively large electric output signals. The signals were fed into a computer model that mimicked some functions of inner hair cells, inner hair cell-auditory nerve synapses, and auditory nerve fibers. In general, the responses of the model to pure-tone burst and complex stimuli accurately represented the discharge rates of high-spontaneous-rate auditory nerve fibers across a range of frequencies greater than 1 kHz and middle to high sound pressure levels. Thus, the model provides a tool to understand information processing in the peripheral auditory system and a basic design for connecting artificial acoustic sensors to the peripheral auditory nervous system. Finally, we discuss the need for stimulus control with an appropriate model of the auditory periphery based on auditory brainstem responses that were electrically evoked by different temporal pulse patterns with the same pulse number.
  • Ryouhei Iwahashi, Takashi Tateno
    IEEJ TRANSACTIONS ON ELECTRICAL AND ELECTRONIC ENGINEERING 7 S71 - S76 1931-4973 2012/12 [Refereed][Not invited]
     
    Concentrations of free intracellular calcium ions ([Ca2+]i) in excitable cells are often measured using indicator dyes, such as fura-2. Of note, however, these indicator dyes are divalent metal ion chelators that affect intrinsic changes in [Ca2+]i. To examine whether indicator dyes alter calcium signaling, we estimated [Ca2+]i using a novel statistical inference method that examines fluorescence signals and the calcium current through the cell membrane. We first constructed a model of transient [Ca2+]i, which was then translated into a state-space model with such state variables as [Ca2+]i, endogenous calcium buffer, and calcium indicators. Then, a self-organizing state-space model was defined by augmenting a state vector with unknown parameters from the original state-space model. In the model, some unknown parameters were estimated with the original state vector. Next, we used a recursive Bayesian estimation to obtain a set of state vectors and the unknown parameters associated with a set of observation vectors. To calculate the recursive Bayesian estimation, we used a sequential Monte Carlo method, which is referred to as a particle filter method. To verify the effectiveness of the proposed method, we carried out experiments with a set of test data from a model with known parameters. The results show that our proposed method properly estimated the temporal profiles of [Ca2+]i, the indicator dye concentration, and certain model parameters in a noisy environment. (c) 2012 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.
  • Takashi Tateno
    IEEJ TRANSACTIONS ON ELECTRICAL AND ELECTRONIC ENGINEERING 7 (3) 283 - 290 1931-4973 2012/05 [Refereed][Not invited]
     
    To examine the functional role of hyperpolarization-activated and cyclic nucleotide-gated (HCN) current observed in mesencephalic dopaminergic neurons, we constructed a conductance-based model that can mimic the electrical properties obtained in electrophysiological recordings of rat brain slices. In the model, blocking the HCN current resulted in a reduction of spontaneous firing rate and a change in the properties of autonomous pacemaking. In addition, reduced one-dimensional phase equations and their coupled oscillators were analyzed. The analysis indicated that HCN channels can regulate the extent of synchronization of coupled dopaminergic neurons through gapjunction connections. Thus, the HCN current can effectively shape the autonomous and cooperative firing of dopaminergic neurons in the midbrain. (C) 2012 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.
  • Simple dynamical models to understand the mechanisms of drug addiction
    T. Tateno
    Advances in Cognitive Neurodynamics III 2012 [Refereed][Not invited]
  • Takashi Tateno, Hugh P. C. Robinson
    JOURNAL OF NEUROPHYSIOLOGY 106 (4) 1901 - 1922 0022-3077 2011/10 [Refereed][Not invited]
     
    Tateno T, Robinson HP. The mechanism of ethanol action on midbrain dopaminergic neuron firing: a dynamic-clamp study of the role of I h and GABAergic synaptic integration. J Neurophysiol 106: 1901-1922, 2011. First published June 22, 2011; doi:10.1152/jn.00162.2011.-Hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels are expressed in dopaminergic (DA) neurons of the ventral tegmental area (VTA) as well as in DA and GABAergic neurons of the substantia nigra (SN). The excitation of DA neurons induced by ethanol has been proposed to result from its enhancing HCN channel current, I h. Using perforated patch-clamp recordings in rat midbrain slices, we isolated I h in these neurons by voltage clamp. We showed that ethanol reversibly increased the amplitude and accelerated the activation kinetics of I h and caused a depolarizing shift in its voltage dependence. Using dynamic-clamp conductance injection, we injected artificial I h and fluctuating GABAergic synaptic conductance inputs into neurons following block of intrinsic I h. This demonstrated directly a major role of I h in promoting rebound spiking following phasic inhibition, which was enhanced as the kinetics and amplitude of I h were changed in the manner induced by ethanol. Similar effects of ethanol were observed on I h and firing rate in non-DA, putatively GABAergic interneurons, indicating that in addition to its direct effects on firing, ethanol will produce large changes in the inhibition and disinhibition (via GABAergic interneurons) converging on DA neurons. Thus the overall effects of ethanol on firing of DA cells of the VTA and SN in vivo, and hence on phasic dopamine release in the striatum, appear to be determined substantially by its action on I h in both DA cells and GABAergic interneurons.
  • Takashi Tateno
    IEEJ Transactions on Electronics, Information and Systems 131 (1) 5 - 55 1348-8155 2011 [Refereed][Not invited]
     
    In this study, I aim to understand morphological changes in dopaminergic neurons of the rat midbrain during early developmental stages and their computational properties in the dendrites. To this end, firstly, I measured morphological details of dopaminergic neurons using an immunochemical double-staining technique. In the viewpoint of the Rail's equivalent-cylinder model, secondly, I tested if the data satisfied one of conditions (3/2 power law) of the Rail's model. On the basis of the experimental data, I next investigated if some branches in the individual dendrites had special selectivity in efficient passive propagation of membrane potentials between the branches of individual cells and different cells. The results show that the Rail's 3/2 power law was not satisfied in many branch points and that among branches of each dendrite, specific selectivity in efficient propagation was not found. In addition, I note an implementation method in which the finite element method is applied to one-dimensional cable model of dendrites and give some numerical examples. © 2011 The Institute of Electrical Engineers of Japan.
  • Nathan W. Gouwens, Hugo Zeberg, Kunichika Tsumoto, Takashi Tateno, Kazuyuki Aihara, Hugh P.C. Robinson
    PLoS Computational Biology 6 (9) 1 - 13 1553-734X 2010/09 [Refereed][Not invited]
     
    Fast-spiking (FS) cells in the neocortex are interconnected both by inhibitory chemical synapses and by electrical synapses, or gap-junctions. Synchronized firing of FS neurons is important in the generation of gamma oscillations, at frequencies between 30 and 80 Hz. To understand how these synaptic interactions control synchronization, artificial synaptic conductances were injected in FS cells, and the synaptic phase-resetting function (SPRF), describing how the compound synaptic input perturbs the phase of gamma-frequency spiking as a function of the phase at which it is applied, was measured. GABAergic and gap junctional conductances made distinct contributions to the SPRF, which had a surprisingly simple piecewise linear form, with a sharp midcycle break between phase delay and advance. Analysis of the SPRF showed how the intrinsic biophysical properties of FS neurons and their interconnections allow entrainment of firing over a wide gamma frequency band, whose upper and lower frequency limits are controlled by electrical synapses and GABAergic inhibition respectively. © 2010 Gouwens et al.
  • Takashi Tateno
    NEUROREPORT 21 (10) 667 - 674 0959-4965 2010/07 [Refereed][Not invited]
     
    To analyze the small-conductance calcium-dependent K+ current observed in dopaminergic neurons of the rat midbrain, we have developed a new dynamic current clamping method that incorporates recording of intracellular Ca2+ levels. As reported earlier, blocking the small-conductance current with apamin shifted the firing modes of dopaminergic neurons and changed the firing rate and spike afterhyperpolarization. We modeled the kinetic properties of the current and assessed the model in a real-time computational system. Here, we show that the spike afterhyperpolarization is regulated by the small-conductance current, an effect that is observed in dopaminergic neurons. Thus, this current can effectively shape the autonomous firing patterns of dopaminergic neurons. NeuroReport 21:667-674 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
  • Hirofumi Shintaku, Takashi Tateno, Nobuyoshi Tsuchioka, Harto Tanujaya, Takayuki Nakagawa, Juichi Ito, Satoyuki Kawano
    Journal of Biomechanical Science and Engineering 5 (3) 229 - 235 1880-9863 2010 [Refereed][Not invited]
     
    In this paper, we report an in vitro study on the biocompatibility of poly(vinylidene fluoride-trifluoroethylene) (P(VDF-TrFE)) films for the implantable artificial cochlea. The implantable artificial cochlea comprises a piezoelectric membrane made of P(VDF-TrFE), platinum (Pt) thin film electrodes, and a silicon substrate which are designed to stimulate neurons in a cochlea and fabricated by microelectromechanical systems (MEMS) and thin film technologies. The biocompatibility of P(VDF-TrFE) film is evaluated by culturing cerebral cortical neurons from rats on it. The fibronectin from human plasma and the collagen from the calf skin are used as the cell adhesion factors. Since neurons extend dendrites and axons from the somata, it is found that the neurons are successfully cultured on the surface of P(VDF-TrFE) films modified both by the fibronectin and by the collagen. Furthermore, it is also found that the neurons are also successfully cultured over the Pt electrode on the P(VDF-TrFE) of the implantable artificial cochlea modified by the fibronectin. Consequently, the biocompatibility and the applicability of the MEMS fabricated P(VDF-TrFE) films and the implantable artificial cochlea are confirmed. © 2010 by JSME.
  • T. Tateno
    IEE Japan Transactions on Electronics, Information and Systems 131 (1) 50 - 55 0385-4221 2010 [Refereed][Not invited]
  • T. Tateno, H. P. C. Robinson
    JOURNAL OF NEUROPHYSIOLOGY 101 (2) 1056 - 1072 0022-3077 2009/02 [Refereed][Not invited]
     
    Tateno T, Robinson HPC. Integration of broadband conductance input in rat somatosensory cortical inhibitory interneurons: an inhibition-controlled switch between intrinsic and input-driven spiking in fast-spiking cells. J Neurophysiol 101: 1056-1072, 2009. First published December 17, 2008; doi: 10.1152/jn.91057.2008. Quantitative understanding of the dynamics of particular cell types when responding to complex, natural inputs is an important prerequisite for understanding the operation of the cortical network. Different types of inhibitory neurons are connected by electrical synapses to nearby neurons of the same type, enabling the formation of synchronized assemblies of neurons with distinct dynamical behaviors. Under what conditions is spike timing in such cells determined by their intrinsic dynamics and when is it driven by the timing of external input? In this study, we have addressed this question using a systematic approach to characterizing the input-output relationships of three types of cortical interneurons (fast spiking [FS], low-threshold spiking [LTS], and nonpyramidal regular-spiking [NPRS] cells) in the rat somatosensory cortex, during fluctuating conductance input designed to mimic natural complex activity. We measured the shape of average conductance input trajectories preceding spikes and fitted a two-component linear model of neuronal responses, which included an autoregressive term from its own output, to gain insight into the input-output relationships of neurons. This clearly separated the contributions of stimulus and discharge history, in a cell-type dependent manner. Unlike LTS and NPRS cells, FS cells showed a remarkable switch in dynamics, from intrinsically driven spike timing to input-fluctuation-controlled spike timing, with the addition of even a small amount of inhibitory conductance. Such a switch could play a pivotal role in the function of FS cells in organizing coherent gamma oscillations in the local cortical network. Using both pharmacological perturbations and modeling, we show how this property is a consequence of the particular complement of voltage-dependent conductances in these cells.
  • I. Tateno, H. P. C. Robinson
    BIOSYSTEMS 89 (1-3) 110 - 116 0303-2647 2007/05 [Refereed][Not invited]
     
    Population oscillations in neural activity in the gamma (>30 Hz) and higher frequency ranges are found over wide areas of the mammalian cortex. Recently, in the somatosensory cortex, the details of neural connections formed by several types of GABAergic interneurons have become apparent, and they are believed to play a significant role in generating these oscillations through synaptic and gap-junctional interactions. However, little is known about the mechanism of how such oscillations are maintained stably by particular interneurons and by their local networks, in a noisy environment with abundant synaptic inputs. To obtain more insight into this, we studied a fast-spiking (FS)-cell model including Kv3-channel-like current, which is a distinctive feature of these cells, from the viewpoint of nonlinear dynamical systems. To examine the specific role of the Kv3-channel in determining oscillation properties, we analyzed basic properties of the FS-cell model, such as the bifurcation structure and phase resetting curves (PRCs). Furthermore, to quantitatively characterize the oscillation stability under noisy fluctuations mimicking small fast synaptic inputs, we applied a recently developed method from random dynamical system theory to estimate Lyapunov exponents, both for the original four-dimensional dynamics and for a reduced one-dimensional phase-equation on the circle. The results indicated that the presence of the Kv3-channel-like current helps to regulate the stability of noisy neural oscillations and a trans ient-peri od length to stochastic attractors. (C) 2007 Published by Elsevier Ireland Ltd.
  • T. Tateno, H. P. C. Robinson
    BIOPHYSICAL JOURNAL 92 (2) 683 - 695 0006-3495 2007/01 [Refereed][Not invited]
     
    Synchronous oscillations in neural activity are found over wide areas of the cortex. Specific populations of interneurons are believed to play a significant role in generating these synchronized oscillations through mutual synaptic and gap-junctional interactions. Little is known, though, about the mechanism of how oscillations are maintained stably by particular types of interneurons and by their local networks. To obtain more insight into this, we measured membrane-potential responses to small current-pulse perturbations during regular firing, to construct phase resetting curves (PRCs) for three types of interneurons: nonpyramidal regular-spiking (NPRS), low-threshold spiking (LTS), and fast-spiking (FS) cells. Within each cell type, both monophasic and biphasic PRCs were observed, but the proportions and sensitivities to perturbation amplitude were clearly correlated to cell type. We then analyzed the experimentally measured PRCs to predict oscillation stability, or. ring reliability, of cells for a complex stochastic input, as occurs in vivo. To do this, we used a method from random dynamical system theory to estimate Lyapunov exponents of the simplified phase model on the circle. The results indicated that LTS and NPRS cells have greater oscillatory stability ( are more reliably entrained) in small noisy inputs than FS cells, which is consistent with their distinct types of threshold dynamics.
  • Takashi Tateno
    NEUROSCIENCE RESEARCH 58 S186 - S186 0168-0102 2007 [Refereed][Not invited]
  • Takashi Tateno
    Complex Medical Engineering 565 - 572 2007 [Refereed][Not invited]
     
    Neurons and dynamical models of spike generation display two different classes of threshold behavior, with steady current stimulation: type 1 and type 2. The dynamics at threshold could have profound effects on the encoding of input as spikes, the sensitivity of spike generation to noisy input, and the coherence of population firing. To comprehend the consequences of spike timing variability during more natural fluctuating input, we compared the postsynaptic firing variability of type-1 regular-spiking pyramidal cells and type-2 fast-spiking interneurons, applying a conductance injection method to rat acute slice preparations in vitro. Using two statistics, the reliability of spike occurrence and the spike jitter, we studied the sensitivity of firing variability to the rate of independent, shunting inhibition and to the correlation in time of synthesized synaptic inputs. The results indicate that differences between the two cell types are consistent with a role of regular-spiking neurons as rate-coding integrators, and a role of fast-spiking neurons as resonators controlling the coherence of synchronous firing.
  • T Tateno, HPC Robinson
    JOURNAL OF NEUROPHYSIOLOGY 95 (4) 2650 - 2663 0022-3077 2006/04 [Refereed][Not invited]
     
    Neurons and dynamical models of spike generation display two different classes of threshold behavior: type 1 [firing frequency vs. current (f-I) relationship is continuous at threshold] and type 2 (discontinuous f-I). With steady current or conductance stimulation, regular-spiking (RS) pyramidal neurons and fast-spiking (FS) inhibitory interneurons in layer 2/3 of somatosensory cortex exhibit type 1 and type 2 threshold behaviors, respectively. We compared the postsynaptic firing variability of type 1 RS and type 2 FS cells, during naturalistic, fluctuating conductance input. In RS neurons, increasing the level of independently random, shunting inhibition caused a monotonic increase in spike reliability, whereas in FS interneurons, there was an optimum level of shunting inhibition for achieving the most reliable spike generation and the most precise spike-time encoding. This was observed over a range of different degrees of synchrony, or correlation, in the input. RS cells displayed a progressive rise in spike jitter during natural-like transient burst inputs, whereas for FS cells, jitter was mostly kept low. Furthermore, RS cells showed encoding of the input level in the spike shape, whereas FS cells did not. These differences between the two cell types are consistent with a role of RS neurons as rate-coding integrators, and a role of FS neurons as resonators controlling the coherence of synchronous firing.
  • T Tateno, Y Jimbo, HPC Robinson
    NEUROSCIENCE 134 (2) 439 - 448 0306-4522 2005 [Refereed][Not invited]
     
    We studied the effects of carbachol, a cholinergic agonist, on extracellularly evoked firing of networks in mature cultures of rat cortical neurons, using multi-electrode arrays to monitor the activity of large numbers of neurons simultaneously. These cultures show evoked burst firing which propagates through dense synaptic connections. When a brief voltage pulse was applied to one extracellular electrode, spiking electrical responses were evoked in neurons throughout the network. The response had two components: an early phase, terminating within 30-80 ms, and a late phase which could last several hundreds of milliseconds. Action potentials evoked during the early phase were precisely timed, with only small jitter. In contrast, the late phase characteristically showed clusters of electrical activity with significant spatio-temporal fluctuations. The late phase was suppressed by applying a relatively small amount of carbachol (5 mu M) in the external solution, even though the spontaneous firing rate was not significantly changed. Carbachol increased both the spike-timing precision and the speed of propagation of population spikes, and selectively increased the firing coincidence in a subset of neuron pairs in the network, while suppressing late variable firing in responses. Hence, the results give quantitative support for the idea that cholinergic activation in the cortex has a general role of focusing or enhancing significant associative firing of neurons. (c) 2005 IBRO. Published by Elsevier Ltd. All rights reserved.
  • T Tateno, Y Jimbo, HPC Robinson
    NEUROSCIENCE 134 (2) 425 - 437 0306-4522 2005 [Refereed][Not invited]
     
    Activation of the cholinergic innervation of the cortex has been implicated in sensory processing, learning, and memory. At the cellular level, acetylcholine both increases excitability and depresses synaptic transmission, and its effects on network firing are hard to predict. We studied the effects of carbachol, a cholinergic agonist, on network firing in cultures of rat cortical neurons, using electrode arrays to monitor the activity of large numbers of neurons simultaneously. These cultures show stable spontaneous synchronized burst firing which propagates through dense synaptic connections. Carbachol (10-50 mu M), acting through muscarinic receptors, was found to induce a switch to asynchronous single-spike firing and to result in a loss of regularity and fragmentation of the burst structure. To obtain a quantitative measure of cholinergic actions on cortical networks, we applied a cluster Poisson-process model to sets of paralleled spike-trains in the presence and absence of carbachol. This revealed that the time series can be well-characterized by such a simple model, consistent with the observed 1/f(b)-like spectra (0.04 < b < 2.08). After applying higher concentrations of carbachol the property of the spectra shifted toward a Poisson-process (white) spectrum. These results indicate that cholinergic neurotransmitters have a strong and reliable desynchronizing action on cortical neural activity. (c) 2005 Published by Elsevier Ltd on behalf of IBRO.
  • T Tateno, A Harsch, HPC Robinson
    JOURNAL OF NEUROPHYSIOLOGY 92 (4) 2283 - 2294 0022-3077 2004/10 [Refereed][Not invited]
     
    Neurons and dynamical models of spike generation display two different types of threshold behavior, with steady current stimulation: type 1 [the firing frequency vs. current (f-I) relationship is continuous at threshold) and type 2 (discontinuous f-I)]. The dynamics at threshold can have profound effects on the encoding of input as spikes, the sensitivity of spike generation to input noise, and the coherence of population firing. We have examined the f-I and frequency-conductance (f-g) relationships of cells in layer 2/3 of slices of young (15-21 DIV) rat somatosensory cortex, focusing in detail on the nature of the threshold. Using white-noise stimulation, we also measured firing frequency and inter-spike interval variability as a function of noise amplitude. Regular-spiking (RS) pyramidal neurons show a type 1 threshold, consistent with their well-known ability to fire regularly at very low frequencies. In fast-spiking (FS) inhibitory interneurons, although regular firing is supported over a wide range of frequencies, there is a clear discontinuity in their f-I relationship at threshold (type 2), which has not previously been highlighted. FS neurons are unable to support maintained periodic firing below a critical frequency f(c), in the range of 10 to 30 Hz. Very close to threshold, FS cells switch irregularly between bursts of periodic firing and subthreshold oscillations. These characteristics mean that the dynamics of RS neurons are well suited to encoding inputs into low-frequency firing rates, whereas the dynamics of FS neurons are suited to maintaining and quickly synchronizing to gamma and higher-frequency input.
  • T Tateno, K Pakdaman
    CHAOS 14 (3) 511 - 530 1054-1500 2004/09 [Refereed][Not invited]
     
    Determining the response characteristics of neurons to fluctuating noise-like inputs similar to realistic stimuli is essential for understanding neuronal coding. This study addresses this issue by providing a random dynamical system analysis of the Morris-Lecar neural model driven by a white Gaussian noise current. Depending on parameter selections, the deterministic Morris-Lecar model can be considered as a canonical prototype for widely encountered classes of neuronal membranes, referred to as class I and class II membranes. In both the transitions from excitable to oscillating regimes are associated with different bifurcation scenarios. This work examines how random perturbations affect these two bifurcation scenarios. It is first numerically shown that the Morris-Lecar model driven by white Gaussian noise current tends to have a unique stationary distribution in the phase space. Numerical evaluations also reveal quantitative and qualitative changes in this distribution in the vicinity of the bifurcations of the deterministic system. However, these changes notwithstanding, our numerical simulations show that the Lyapunov exponents of the system remain negative in these parameter regions, indicating that no dynamical stochastic bifurcations take place. Moreover, our numerical simulations confirm that, regardless of the asymptotic dynamics of the deterministic system, the random Morris-Lecar model stabilizes at a unique stationary stochastic process. In terms of random dynamical system theory, our analysis shows that additive noise destroys the above-mentioned bifurcation sequences that characterize class I and class II regimes in the Morris-Lecar model. The interpretation of this result in terms of neuronal coding is that, despite the differences in the deterministic dynamics of class I and class II membranes, their responses to noise-like stimuli present a reliable feature. (C) 2004 American Institute of Physics.
  • T. Tateno, K. Pakdaman
    Journal of Nonlinear Science 14 511 - 530 2004 [Refereed][Not invited]
  • Y Jimbo, N Kasai, K Torimitsu, T Tateno, HPC Robinson
    IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING 50 (2) 241 - 248 0018-9294 2003/02 [Refereed][Not invited]
     
    The capability for multisite stimulation is one of the biggest potential advantages of microelectrode arrays (MEAs). There remain, however, several technical problems which have hindered the development of a practical stimulation system. An important design goal is to allow programmable multisite stimulation, which produces minimal interference with simultaneous extracellular and patch or whole cell clamp recording. Here, we describe a multisite stimulation and recording system with novel interface circuit modules, in which preamplifiers; and transistor transistor logic-driven solid-state switching devices are integrated. This integration permits PC-controlled remote switching of each substrate electrode. This allows not only flexible selection of stimulation sites, but also rapid switching. of the selected sites between stimulation and recording, within 1.2 ms. This allowed almost continuous monitoring of extracellular signals at all the substrate-embedded electrodes, including those used for. stimulation. In addition, the vibration-free solid-state switching made it possible to record whole-cell synaptic currents in one neuron, evoked from multiple sites in the network. We have used this system to visualize spatial propagation patterns. of evoked responses in cultured networks of cortical neurons. This MEA-based stimulation system is a useful tool for studying neuronal signal processing in biological neuronal networks, as well as the process of synaptic integration within single neurons.
  • Takashi Tateno, Akio Kawana, Yasuhiko Jimbo
    Physical Review E - Statistical, Nonlinear, and Soft Matter Physics 65 (5) 051924/16  1539-3755 2002/05 [Refereed][Not invited]
     
    We have used a multiunit electrode array in extracellular recording to investigate changes in the firing patterns in networks of developing rat cortical neurons. The spontaneous activity of continual asynchronous firing or the alternation of asynchronous spikes and synchronous bursts changed over time so that activity in the later stages consisted exclusively of synchronized bursts. The spontaneous coordinated activity in bursts produced a variability in interburst interval (IBI) sequences that is referred to as "form." The stochastic and nonlinear dynamical analysis of IBI sequences revealed that these sequences reflected a largely random process and that the form for relatively immature neurons was largely oscillatory while the form for the more mature neurons was Poisson-like. The observed IBI sequences thus showed changes in form associated with both the intrinsic properties of the developing cells and the neural response to correlated synaptic inputs due to interaction between the developing neural circuits. © 2002 The American Physical Society.
  • T. Tateno
    Physical Review E (65:021901) 021901  1539-3755 2002/02 [Refereed][Not invited]
  • T. Tateno, Y. Jimbo
    Physics Letters A (271) 227 - 236 2000 [Refereed][Not invited]
  • Y Jimbo, T Tateno, HPC Robinson
    BIOPHYSICAL JOURNAL 76 (2) 670 - 678 0006-3495 1999/02 [Refereed][Not invited]
     
    Activity-dependent modification of synaptic efficacy is widely recognized as a cellular basis of learning, memory, and developmental plasticity. Little is known, however, of the consequences of such modification on network activity. Using electrode arrays, we examined how a single, localized tetanic stimulus affects the firing of up to 72 neurons recorded simultaneously in cultured networks of cortical neurons, in response to activation through 64 different test stimulus pathways. The same tetanus produced potentiated transmission in some stimulus pathways and depressed transmission in others. Unexpectedly, responses were homogeneous: for any one stimulus pathway, neuronal responses were either all enhanced or all depressed. Cross-correlation of responses with the responses elicited through the tetanized site revealed that both enhanced and depressed responses followed a common principle: activity that was closely correlated before tetanus with spikes elicited through the tetanized pathway was enhanced, whereas activity outside a 40-ms time window of correlation to tetanic pathway spikes was depressed. Response homogeneity could result from pathway-specific recurrently excitatory circuits, whose gain is increased or decreased by the tetanus, according to its cross-correlation with the tetanized pathway response. The results show how spatial responses following localized tetanic stimuli, although complex, can be accounted for by a simple rule for activity-dependent modification.
  • T Tateno, Y Jimbo
    BIOLOGICAL CYBERNETICS 80 (1) 45 - 55 0340-1200 1999/01 [Refereed][Not invited]
     
    To study the use-dependent modification of activity in neural networks, we investigated the spike timing by simultaneously recording activity at multiple sites in a network of cultured cortical neurons. We used dynamical analysis to study the temporal structure of spike trains and the activity-dependent changes in the reliability and reproducibility of spike patterns evoked by a stimulus. We also used cross-correlation analysis to evaluate the interactions of neuron pairs. Our main conclusions are that even when no obvious change in spike numbers can be seen, use-dependent modification occurs, either enhancing or reducing in the reliability and reproducibility of spike trains evoked by a stimulus, and the fine temporal structure of stimulus-evoked spike trains and interactions between neurons are also modified by tetanic stimulation.
  • T Tateno
    JOURNAL OF STATISTICAL PHYSICS 92 (3-4) 675 - 705 0022-4715 1998/08 [Refereed][Not invited]
     
    This study of the effect of noise on bifurcations in a simple biological oscillator with a periodically modulated threshold uses the first-passage-time problem of the Ornstein-Uhlenbeck process with a periodic boundary to define the operator governing the transition of a threshold phase: density. Stochastic phase locking is analyzed numerically by evaluating the evolution of the probability density function of the threshold phase. A firing phase map in a noisy environment is extended to a stochastic kernel ss that stochastic bifurcations can be investigated by spectral analysis of the kernel.
  • T TATENO, SJ DOI, S SATO, LM RICCIARDI
    JOURNAL OF STATISTICAL PHYSICS 78 (3-4) 917 - 935 0022-4715 1995/02 [Refereed][Not invited]
     
    Noise effects on phase lockings in a system consisting of a piecewise-linear van der Pol relaxation oscillator driven by a periodic input are studied. The problem of finding the period of the oscillator is reduced to the first-passage-time problem of the Ornstein-Uhlenbeck process with time-varying boundary. The probability density functions of the first-passage time are used to define the operator which governs a transition of an input phase density after one cycle of the oscillator. Phase lockings in a stochastic sense are investigated on the basis of the density evolution by the operator.
  • A note on stochastic phase lockings in a relaxation oscillator forced by a periodic input with additive noise
    T. Tateno, S. Doi, S. Sato, L. M. Ricciardi
    Nuovo Cimento 17 949 - 958 1995 [Refereed][Not invited]
  • Hybrid-type modeling of the peripheral auditory system using a piezoelectric acoustic sensor as a front-end transducer for sound processing
    T. Tateno
    [Refereed][Not invited]
  • Developing technology that integrates microdevices and the auditory central nervous system ― Microstructure devices and functional artificial auditory organs
    T. Tateno
    [Refereed][Not invited]

Books etc

  • Phase-resetting analysis of gamma-frequency synchronization of cortical fast-spiking interneurons using synaptic-like conductance injection”, in Phase response curves in neuroscience: theory, experiment and analysis
    P. Zeberg, N. W. Gouwens, K. Tsumoto, T. Tateno, K. Aihara, H. P. C. Robinson (Joint work)
    2012
  • Dynamics of Cortical Neurons and Spike Timing Variability”, in Complex Medical Engineering
    Takashi Tateno (Single work565-572)
    2007
  • Simple dynamical models to understand the mechanisms of drug addiction
    Takashi Tateno (Single workChap. 93, Advances in Cognitive Neurodynamics (III)")
    Springer

Conference Activities & Talks

  • Neural activity related to auditory induction in some fields of rat auditory cortex: a study of optical imaging with a voltage-sensitive dye  [Not invited]
    Masanari Noto, Jun Nisikawa, Takashi Tateno
    The Auditory Research Meeting Sponsored by the Technical Commitee of Psychological and Physiological Acoustics  2013/11
  • Voltage-sensitive dye imaging of unidirectional dual-component propagation of activity evoked by sound and electrical stimulation in rat multiple auditory cortical fields  [Not invited]
    Jun Nnishikawa, Masanari Noto, Hiroyuki Kitamura, Takashi Tateno
    The 43rd Annual Meeting of the Society for Neuroscience (Neuroscience 2013)  2013/11
  • Multielectrode array recording of propagation of activity evoked by electrical micro-stimulation in horizontaland coronal slices of the mouse auditory cortex  [Not invited]
    Hiroyuki Kitamura, Jun Nishikawa, Takashi Tateno
    The 43rd Annual Meeting of the Society for Neuroscience (Neuroscience 2013)  2013/11
  • Functional asymmetry in the rat auditory cortex: analysis of preferred propagation-directions of neural activity evoked by sound and electrical stimulation  [Not invited]
    Jun Nishikawa, Masanari Noto, Hiroyuki Kitamura, Takashi Tateno
    The Institute of Electorical Engineers in Japan, Electronics, Information and Systems  2013/09
  • Synaptic dysfunction and defective activity propagation in hippocampus CA1 of young senescence-accelerated mice  [Not invited]
    Hiroyuki Kitamura, Takashi Tateno
    The 36th Annual Meeting of the Japan Neuroscience Society (Neuroscience 2013)  2013/06
  • Voltage-sensitive dye imaging of unidirectional dual-component propagation of activity evoked by sound and electrical stimulation in rat multiple auditory cortical fields  [Not invited]
    Jun Nishikawa, Masanari Noto, Takashi Tateno
    The 36th Annual Meeting of the Japan Neuroscience Society (Neuroscience 2013)  2013/06
  • 情報科学から知る医療応用 大学研究の最前線~最先端の科学と医療を学んでみよう~  [Not invited]
    平田拓, 近野敦, 舘野高
    2013/06
  • やさしい情報科学とライフイノベーション  [Not invited]
    平田拓, 近野敦, 舘野高
    北海道大学大学院情報科学研究科 公開講座サスティナビリティーウィーク  2012/10
  • Recording and evaluatng electrically evoked responses in hippocampal slices usind a planar multielectrode array and standard and inverse current-souce destiny analysis  [Not invited]
    H.Kitamura, T.Tateno
    The 42nd Annual Meeting of the Society for Neuroscience (Neuroscience 2012)  2012/10
  • Integration of a piezoelectric acoustic sensor and an inner-hair-cell and auditory-nerve-fiber complex model as a front-end transducer for sound processing  [Not invited]
    Takashi Tateno, Hiroyuki Kitamura
    The 35th Annual Meeting of the Japan Neuroscience Society (Neuroscience 2012),  2012/09
  • 急性海馬スライスにおける局所電気刺激に対する誘発応答の他店記録―標準及び逆電流源密度解析法の評価―  [Not invited]
    北村宏幸, 紺野雄輝, 西川淳, 舘野高
    電気学会 電子・情報・システム部門大会  2012/09
  • Hybrid-type computational modeling of the peripheral auditory system using a piezoelectric acoustic sensor as a front-end transducer for sound processing  [Not invited]
    Takashi Tateno
    8th FENS Forum of Neuroscience  2012/07
  • Developing a thin-film electrode system to record in-vivo cortical responses evoked by an artifical peripheral auditory device  [Not invited]
    H. Kitamura, J.Nishikawa, T.Tatno
    MEA Meeting 2012 8th International Meeting on Substrate-Integrated Microelectrode Arrays  2012/07
  • The mechanism of ethanol action on midbrain dopaminergic neuron firing: A dynamic-clamp study of the role of I_h and GABAergic synaptic integration  [Not invited]
    T. Tateno, H.P.C. Robinson
    The 41st Annual Meeting of Society for Neuroscience (Neuroscience 2011)  2011/11
  • 彩都科学体験教室  [Not invited]
    舘野高
    彩都科学体験教室  2011/11
  • The mechanism of ethanol action on mesencephalic dopaminergic neuron firing: the roles of hyperpolarization-activated inward current and GABAergic synaptic integration,"  [Not invited]
    T. Tateno, H.P.C. Robinson
    Neuroscience 2011  2011/09
  • 圧電音響センサを応用した聴覚末梢系モデリング  [Not invited]
    舘野高
    電気学会 電子・情報・システム部門大会  2011/09
  • The mechanism of ethanol action on mesencephalic dopaminergic neuron firing: the roles of hyperpolarization-activated inward current and GABAergic synaptic integration  [Not invited]
    T. Tateno, H.P.C. Robinson
    Neuroscience 2011  2011/09
  • Simple dynamical models to understand the mechanisms of drug addiction  [Not invited]
    T. Tateno
    The 3rd International Conference on Cognitive Neurodynamics  2011/06
  • 音と耳の織りなす諸現象―聴覚イリュージョンの仕掛けと耳の仕組み-  [Not invited]
    舘野高
    大阪大学大学院基礎工学研究科公開講座  2010/08
  • Hybrid-system modeling in electrophysiology - Application of a dynamic-clamp technique  [Not invited]
    Takashi Tateno
    Workshop on Computational Neuroscience in Ritsumei University  2010/03
  • マイクロデバイスを応用した神経細胞活動計測  [Not invited]
    舘野高
    数理医療セミナー  2008/12

MISC

  • 河野通太, 舘野高  電子情報通信学会技術研究報告. NC, ニューロコンピューティング  108-  (480)  87  -92  2009/03/04  [Not refereed][Not invited]
     
    本研究では,大脳基底核黒質緻密部におけるドーパミン作動性(DA)細胞の時空間的シナプス入力の統合とその符号化様式を理解するために,まず,二重免疫染色法を用いて,ラット黒質部のDA細胞形態を詳細に計測した.次に,Rallの等価シリンダモデルの観点から,実際に計測した細胞形態データが,そのモデル化の条件を満たすか否かを検討した.さらに,DA細胞を受動的膜と見なした場合に,樹状突起の分岐点で膜電位伝達の効率性を理解することを試みた.特に,細胞間,あるいは,細胞内で膜電位を効率的に伝播する特異的樹状突起を有しているかについて実験データを基に検証した.また,有限要素法を応用した樹状突起モデルの一構成法の計算機による実装方法とその具体的な応用例を述べる.
  • 岩橋亮平, 舘野高  電子情報通信学会技術研究報告. NC, ニューロコンピューティング  107-  (542)  255  -260  2008/03/05  [Not refereed][Not invited]
     
    本研究では,大脳基底核黒質緻密部の局所回路特性の理解を目指して,ラット脳切片を用いて神経細胞の電気的特性を実験的に調べた.特に,黒質の神経細胞の電気生理学特性に基づく細胞分類の可能性を検討する為に,ホールセルパッチクランプ法を用いて細胞の膜電位と電流を計測した.その結果,まず,先行研究が示すように,活動電位の幅が広く低周波数で発火する神経細胞(第一細胞)と活動電位の幅が狭く高周波数で発火する神経細胞(第二細胞)の二種類に分類できた.次に,免疫組織化学法を用いて,電気活動を計測した第一細胞がドーパミン作動性(DA)であるかを調べた.その結果,第一細胞には,DAと非DAが混在していることが判った.さらに,第二細胞群をいくつかの電気的特徴からサブタイプに分類できるかを検討した.細胞間には,その特徴が大きく異なっているものが存在するが,細胞群全体の特徴パラメータはその空間上に連続的に分布しており,単純な基準ではサブタイプに分類することが困難であることが判明した.
  • 阿登正憲, 舘野高  電子情報通信学会技術研究報告. NC, ニューロコンピューティング  106-  (588)  43  -48  2007/03/07  [Not refereed][Not invited]
     
    近年,大脳皮質体性感覚野において,抑制性介在細胞が細胞種毎に特異的な細胞間結合を形成することが明らかになってきた.しかし,現在,各細胞種が神経回路網の中でどのような役割を果たしているかは明確ではない.本研究では,抑制性介在細胞の中でfast spiking細胞とよばれる神経細胞とそのK^+チャネルに着目した.まず,生理実験と計算機シミュレーションによって,周期的な発火活動中に摂動電流を印加し,動的特性を知る為に位相反応曲線を計測,および,推定した.得られた位相反応曲線を基に,周期振動における一次元位相方程式モデルを作成した.そして,確率的力学系理論に基づき,白色雑音下の位相方程式の振動安定性の指数を計算した.その結果,イオンチャネル種の相対的な寄与の大きさによって,振動安定性に違いがあることが判明した.本稿では,こうした結果を基に,神経回路網におけるfast spiking細胞とそのK^+チャネル電流の役割を議論する.
  • 舘野高  電子情報通信学会技術研究報告. NC, ニューロコンピューティング  105-  (658)  13  -18  2006/03/09  [Not refereed][Not invited]
     
    近年,大脳皮質体性感覚野において,抑制性介在細胞が細胞種毎に特異的な細胞間結合を形成することが明らかになってきた.しかし,それらの細胞種に関して,神経振動における安定性が定量的にどの程度かは知られていない.本研究では,まず,非線形力学系の観点から,細胞種分類が可能か否かを検討した.そして,周期的な発火活動中に微小な電流外乱を印加し,実験的に位相反応曲線を計測した.得られた位相反応曲線を下に,周期振動における一次元位相方程式モデルを作成した.そして,確率的力学系理論に基づき,白色雑音下の位相方程式の振動安定性指数を計算した.その結果,細胞種間に振動安定性の違いがあることが判明した.本稿では,こうした結果を基に,神経回路網における細胞種の役割を議論する.
  • 舘野高  電子情報通信学会技術研究報告. NLP, 非線形問題  100-  (608)  71  -78  2001/01/25  [Not refereed][Not invited]
     
    本研究では, 単位円上の単純な一次元2状態系を扱う。この系は振動, 興奮, 双(多)安定な振舞いを示す。システムの確率的現象の性質を知るために, 信号対雑音比, パワー・スペクトル, Lyapunov指数などの道具を準備する。システムの分岐点近傍での確率的現象と出力コヒーレンスとの関係を理解することを目的とし, その第一歩として, これらの道具を用いて数値解析を行った結果を本稿では述べる。
  • 鶴賀英高, 舘野高, 佐藤俊輔  電子情報通信学会技術研究報告. MBE, MEとバイオサイバネティックス  100-  (98)  133  -140  2000/05/19  [Not refereed][Not invited]
     
    本研究では, 神経束の情報伝達を調べるために, 並列構造をもつ多数の神経モデルの応答の全体効果を評価する.我々は, ノイズ存在下での周期的シナプス入力を受けるleaky integrate-and-fire神経モデル(LIFM)集合の応答特性を調べる.LIFM集合の応答は各ユニットの出力スパイク列の総和からなる点過程であり, その発火分布を数値計算し, 入力とノイズのパラメータによる発火特性を調べる.さらに, ポアソン過程に基づく発火間隔分布とLIFMの微分方程式から得たスパイク列の分布を, Kullback-Leibler情報量を用いて比較する.我々の結果は, 神経束による情報伝達と符号化を評価するために, 感覚末梢系のモデルとして応用することができる.

Industrial Property Rights

  • 特願2018-13215:磁気コイル装置、コイル群へ印加する電流の設定方法およびコイル群へ印加する電流を設定するプログラム  2018年/01/30
    舘野高, 三幣俊輔
  • 特願PCT/JP2011/052164:電気生理測定装置及び方法  2011年/02/02
    舘野高  
    国際出願
  • 特願2010-032646:電気生理測定装置及び方法  2010年/02/07
    舘野高

Research Grants & Projects

  • 聴覚中枢神経マイクロ・インプラントにおける システム・インテグレーションの基盤形成
    内閣府:次世代・最先端研究開発支援プロジェクト
    Date (from‐to) : 2010/02 -2014/03 
    Author : 舘野高
  • 神経幹細胞の膜動態を誘導するリバース・エンジニアリング法の開発
    科学研究費補助金 萌芽研究
    Date (from‐to) : 2008/04 -2013/03 
    Author : 舘野高
  • 次世代人工感覚器の為のマイクロデバイス・システムインテグレーションの基盤形成
    科学研究費補助金 基盤研究(B)
    Date (from‐to) : 2009/04 -2012/03 
    Author : 舘野高
  • 大脳基底核回路網のハイブリッドシステムモデリング
    JSTさきがけ:JSTさきがけ研究
    Date (from‐to) : 2007/04 -2012/03 
    Author : 舘野高
  • MEMS/NEMS技術を用いた人工感覚上皮の開発に関する研究
    厚生労働省:厚生労働科学研究費補助金
    Date (from‐to) : 2010/04 -2011/03 
    Author : 舘野高
  • 発現遺伝子と細胞動態の相関情報から探る細胞集団の同期的活動生起と崩壊の統合的理解
    科研費新学術領域研究 公募研究
    Date (from‐to) : 2010/04 -2011/03 
    Author : 舘野高
  • ナノテクノロジー,神経生理学および臨床医学を融合した細胞機能診断技術の創成
    大阪大学基礎工学研究科:「未来研究ラボシステム」助成
    Date (from‐to) : 2007/04 -2010/03 
    Author : 舘野高
  • ダイナミッククランプ法による神経回路網ハイブリッドシステムの構築と動的安定性解析
    科学研究費補助金 萌芽研究
    Date (from‐to) : 2006/04 -2009/03 
    Author : 舘野高
  • デジタルプロセッサと神経細胞のハイブリッドシステム相互作用から理解する脳の可塑的潜在能力
    大川情報通信:大川情報通信基金助成金
    Date (from‐to) : 2007/04 -2008/03 
    Author : 舘野高
  • 量子ドットプローブを用いたパーキンソン病関連タンパク質の可視化とドーパミン細胞の電気的活動計測
    村田財団学術振興財団:村田財団学術振興財団助成金
    Date (from‐to) : 2007/04 -2008/03 
    Author : 舘野高
  • 音環境の情報処理系としての聴覚末梢・中枢系の統合的理解の研究
    科学研究費補助金,基盤研究(B)
    Date (from‐to) : 2006/04 -2008/03 
    Author : 舘野高
  • 多電極アレイ記録システムを用いた聴覚中枢系における神経伝達物質による活動修飾の可視化に関する研究
    千里ライフサイエンス振興財団:千里ライフサイエンス振興財団助成金
    Date (from‐to) : 2006/03 -2007/04 
    Author : 舘野高
  • 大脳皮質神経活動のマルチスケーリング現象の測定と解析
    日本学術振興会海外特別研究員
    Date (from‐to) : 2002/09 -2004/08 
    Author : 舘野高
  • 聴覚情報処理における背景雑音が信号検出に果たす機能的役割
    科学研究費補助金,基盤研究(B)
    Date (from‐to) : 2000/04 -2002/03 
    Author : 舘野高

Educational Activities

Teaching Experience

  • Biosystems control and engineering
    開講年度 : 2020
    課程区分 : 修士課程
    開講学部 : 情報科学研究科
    キーワード : 中枢神経系,神経シグナル伝達,感覚情報処理とその補償器,脳刺激法,学習・記憶,運動プログラムと制御,神経活動の大規模計測,計算論的神経科学,神経活動の制御技術,脳の機能補償と機能拡張
  • Neural Control Engineering
    開講年度 : 2020
    課程区分 : 修士課程
    開講学部 : 情報科学院
    キーワード : 中枢神経系,神経シグナル伝達,感覚情報処理とその補償器,脳刺激法,学習・記憶,運動プログラムと制御,神経活動の大規模計測,計算論的神経科学,神経活動の制御技術,脳の機能補償と機能拡張
  • Bioengineering
    開講年度 : 2020
    課程区分 : 修士課程
    開講学部 : 情報科学研究科
    キーワード : 遺伝情報, genetic information, バイオインフォマティクス, bioinformatics, イメージング, imaging, 生体医工学, biomedical engineering, 細胞力学, cell mechanics
  • Biosystems control and engineering
    開講年度 : 2020
    課程区分 : 博士後期課程
    開講学部 : 情報科学研究科
    キーワード : 中枢神経系,神経シグナル伝達,感覚情報処理とその補償器,脳刺激法,学習・記憶,運動プログラムと制御,神経活動の大規模計測,計算論的神経科学,神経活動の制御技術,脳の機能補償と機能拡張
  • Neural Control Engineering
    開講年度 : 2020
    課程区分 : 博士後期課程
    開講学部 : 情報科学院
    キーワード : 中枢神経系,神経シグナル伝達,感覚情報処理とその補償器,脳刺激法,学習・記憶,運動プログラムと制御,神経活動の大規模計測,計算論的神経科学,神経活動の制御技術,脳の機能補償と機能拡張
  • Bioengineering
    開講年度 : 2020
    課程区分 : 博士後期課程
    開講学部 : 情報科学研究科
    キーワード : 遺伝情報, genetic information, バイオインフォマティクス, bioinformatics, イメージング, imaging, 生体医工学, biomedical engineering, 細胞力学, cell mechanics
  • Simulation Engineering
    開講年度 : 2020
    課程区分 : 学士課程
    開講学部 : 工学部
    キーワード : シミュレーション,数値解析,連立方程式,数値積分,微分方程式,補間法,近似法,行列の固有値
  • Biological Cybernetics
    開講年度 : 2020
    課程区分 : 学士課程
    開講学部 : 工学部
    キーワード : 脳・神経系の構造 神経細胞 シナプス 感覚系の情報処理 記憶と学習 情動と精神疾患 脳活動の記録と制御 脳刺激法 運動の制御
  • Neural Engineering
    開講年度 : 2020
    課程区分 : 学士課程
    開講学部 : 工学部
    キーワード : 脳・神経系の構造 神経細胞 シナプス 感覚系の情報処理 記憶と学習 情動と精神疾患 脳活動の記録と制御 脳刺激法 運動の制御


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