Researcher basic information

• Ph.D., Hokkaido University, Mar. 2011

• https://researchmap.jp/aaraki?lang=en

• https://researchers.general.hokudai.ac.jp/profile/ja.5bee2d734c4426ba520e17560c007669.html
• https://researchers.general.hokudai.ac.jp/profile/en.5bee2d734c4426ba520e17560c007669.html

• Environmental Epidemilogy, Health Science, Indoor Air Quality, Environmental Chemicals, Phthalates, Phosphate Flame Retardants, PFAS, allergy, reproductive hormones, birth cohort

• Life Science, Hygiene and public health: excluding laboratory approach
• Life Science, Hygiene and public health: including laboratory approach

• Bachelor's degree program, Departments of Health Sciences, School of Medicine
• Master's degree program, Graduate School of Health Sciences
• Doctoral (PhD) degree program, Graduate School of Health Sciences

Research activity information

• Dec. 2024, Hokkaido University, Yoshie Katsurada Award

• Associations of prenatal exposure to organophosphate pesticides with eczema and allergic rhinoconjunctivitis in 4-year-old children: The Japan Environment and Children's Study
  Megasari Marsela; Hiroyoshi Iwata; Yu Ait Bamai; Mariko Itoh; Rahel Mesfin Ketema; Takeshi Yamaguchi; Yasuaki Saijo; Yoshiya Ito; Sachiko Itoh; Keiko Yamazaki; Naomi Tamura; Keitaro Makino; Maki Tojo; Reiko Kishi; Atsuko Ikeda
  Environmental Research, 123839, 123839, Elsevier BV, Feb. 2026, [Peer-reviewed], [Last author, Corresponding author]
  Scientific journal
• Childhood obesity and DNA methylation in an epigenome-wide association study: findings from the Hokkaido Birth Cohort
  Hiroyoshi Iwata; Chihiro Miyashita; Takeshi Yamaguchi; Atsuko Ikeda; Ryu Miura; Machiko Minatoya; Naomi Tamura; Yu Ait Bamai; Sachiko Itoh; Keiko Yamazaki; Rahel Mesfin Ketema; Mariko Itoh; Maki Tojo; Rieko Yamamoto; Keitaro Makino; Reiko Kishi
  Clinical Epigenetics, Springer Science and Business Media LLC, 01 Dec. 2025, [Peer-reviewed]
  Scientific journal
• Toxic metals and trace elements in maternal blood and urinary tract infection during the first 2 years of life: The Japan Environment and Children's Study
  Keitaro Makino; Hiroyoshi Iwata; Takeshi Yamaguchi; Atsuko Ikeda; Yu Ait Bamai; Sachiko Itoh; Mariko Itoh; Maki Tojo; Naomi Tamura; Rieko Yamamoto; Rahel Mesfin Ketema; Yasuaki Saijo; Yoshiya Ito; Reiko Kishi
  Science of The Total Environment, 1006, 180895, 180895, Elsevier BV, Dec. 2025, [Peer-reviewed]
  Scientific journal
• The impact of pediatric constipation on appendicitis: a prospective birth cohort in the Japan Environment and Children's Study.
  Hiroyoshi Iwata; Takeshi Yamaguchi; Sachiko Itoh; Yu Ait Bamai; Atsuko Ikeda; Keitaro Makino; Mariko Itoh; Maki Tojo; Rieko Yamamoto; Naomi Tamura; Rahel Mesfin Ketema; Yasuaki Saijo; Yoshiya Ito; Reiko Kishi
  BMC pediatrics, 25, 1, 962, 962, 26 Nov. 2025, [Peer-reviewed], [International Magazine]
  English, Scientific journal, BACKGROUND: This study aimed to examine the association between constipation and appendicitis in children using data from a nationwide birth cohort, the Japan Environment and Children's Study (JECS). METHODS: Data were obtained from 64,772 children and their mothers participating in JECS, which included over 100,000 pregnancies across 15 regional centres in Japan. Pediatric constipation was assessed at age three using the Rome III criteria, while appendicitis cases were identified between ages three to four. Logistic regression analyses, including univariable and multivariable models, were conducted to evaluate associations. Additional analyses were stratified by sex. RESULTS: Among the 64,772 children analyzed, 156 cases of appendicitis were identified between the ages of 3 and 4 years. Logistic regression suggested a possible association between constipation and an increased risk of appendicitis (univariable odds ratio [OR]: 1.38, 95% confidence interval [CI]: 0.87–2.10; multivariable OR: 1.36, 95% CI: 0.86–2.06). Although the associations did not reach statistical significance, the point estimates consistently indicated a trend toward increased risk. CONCLUSION: Although our analyses of children aged 3–4 years did not yield statistically significant associations, the observed trends may suggest a potential link between constipation and appendicitis. These findings should be interpreted only as exploratory, and further studies in different age groups, including older children and adults, are warranted to confirm or refute this possible association. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12887-025-06263-7.
• 液体クロマトグラフィー-タンデム質量分析法による北海道産母乳中のplasmalogenの定量(Quantitation of plasmalogen in Hokkaido maternal breast milk by liquid chromatography-tandem mass spectrometry)
  陳 一凡; Ueda Rinako; Gowda Siddabasave Gowda B.; Gowda Divyavani; Miyashita Chihiro; Ikeda Atsuko; Hui Shu-Ping
  日本未病学会学術総会抄録集, 32回, jma32002, 00035, (一社)日本未病学会, Nov. 2025
  English
• Whole-Body SAR Evaluation under Far-Field Exposure with Daily Posture Variability: Toward an Epidemiologically Relevant Assessment
  Koki Kusakabe; Takashi Hikage; Toshihiko Nishimura; Tatsuya Kashiwa; Naomi Tamura; Yu Ait Bamai; Atsuko Ikeda; Reiko Kishi
  2025 International Symposium on Antennas and Propagation (ISAP), 1, 2, IEEE, 27 Oct. 2025
  International conference proceedings
• Cord Blood Mitochondrial DNA Copy Number and Physical Growth in Infancy and Toddlerhood: A Birth Cohort Analysis
  Hisanori Fukunaga; Takeshi Yamaguchi; Hiroyoshi Iwata; Atsuko Ikeda
  Children, 12, 10, 1369, 1369, MDPI AG, 10 Oct. 2025, [Peer-reviewed]
  Scientific journal, Background/Objectives: Cord blood mitochondrial DNA copy number (mtDNAcn) has been proposed as a biomarker reflecting environmental influences during fetal life, with reported associations with perinatal outcomes such as birth weight and length. Within the framework of the Developmental Origins of Health and Disease (DOHaD) theory, this study aimed to investigate whether cord blood mtDNAcn is related to postnatal physical growth in early childhood. Methods: We analyzed data from 150 newborns (68 females and 82 males) enrolled in the Tohoku Medical Megabank Birth and Three-Generation Cohort Study in Japan. Cord blood mtDNAcn was quantified using real-time PCR, and standard deviation scores for weight and height were assessed at 1, 2–3, 4–6, 18–24, and 36–48 months of age. Correlation analyses were conducted separately by sex. Results: Cord blood mtDNAcn showed no significant associations with body weight or height at any of the postnatal time points up to 48 months of age. Growth trajectories of infants with higher or lower mtDNAcn values at birth tended to converge toward the population mean during infancy and toddlerhood. Conclusions: Although no significant relationships were observed, this exploratory, hypothesis-generating study provides a foundation for future investigations. Larger cohorts with extended follow-up are needed to clarify the potential significance of cord blood mtDNAcn in early-life research on child growth and health.
• Prediction of Kawasaki disease coronary artery lesions in the Japan Environment and Children’s Study
  Hiroyoshi Iwata; Takeshi Yamaguchi; Naomi Tamura; Yu Ait Bamai; Atsuko Ikeda; Mariko Itoh; Rieko Yamamoto; Maki Tojo; Rahel Mesfin Ketema; Keiko Yamazaki; Sachiko Itoh; Keitaro Makino; Satoru Shida; Yasuaki Saijo; Yoshiya Ito; Reiko Kishi
  Annals of Pediatric Cardiology, 18, 5, 437, 446, Ovid Technologies (Wolters Kluwer Health), Sep. 2025, [Peer-reviewed]
  Scientific journal, Objective:
  
  This study aimed to validate a composite of previously identified risk factors for predicting coronary artery lesions in Japanese children with Kawasaki Disease (KD).
  
  Materials and Methods:
  
  Children diagnosed with KD from the Japan Environment and Children’s Study (JECS) cohort were included. We assessed the discriminative ability of the model using the area under the curve (AUC) and evaluated its calibration using calibration plots. Based on clinical insights, we derived our original model, which consisted of variables established in previous score models or studies. Using the bootstrap method, internal validation was assessed with the AUC and calibration slope.
  
  Results:
  
  Our analysis included 959 children with KD, derived from 104,062 pediatric records contained in the JECS. Our model comprised the following variables: sex, hematocrit, platelet count, C-reactive protein, and serum sodium levels. The mean and 95% confidence intervals of the AUCs for the Harada, Egami, and Kobayashi models were 0.66 (0.59–0.72), 0.59 (0.52–0.66), and 0.64 (0.56–0.72), respectively. Our score model with bootstrap analyses produced an AUC of 0.80 (0.68–0.91) and a calibration slope of 1.01.
  
  Conclusions:
  
  We built and evaluated our score model using indicators that were easily accessible with a moderate-to-high AUC and stable calibration results, indicating the high reliability of the model for clinical application. Further studies are required to validate our model in other cohorts.
• LC-MS/MSによる母乳中のplasmalogenの定量(Quantitation of plasmalogen in maternal breast milk by LC-MS/MS)
  Chen Yifan; Ueda Rinako; Gowda Siddabasave Gowda B.; Gowda Divyavani; Miyashita Chihiro; Ikeda Atsuko; Hui Shu-Ping
  JSBMS Letters, 50, Suppl., 90, 90, (一社)日本医用マススペクトル学会, Aug. 2025
  English
• Development of a Liquid Chromatography-Tandem Mass Spectrometry Method for Oxylipin Analysis and Its Application to Children's Plasma.
  Yonghan Li; Siddabasave Gowda B Gowda; Divyavani Gowda; Atsuko Ikeda; Yu Ait Bamai; Rahel Mesfin Ketema; Reiko Kishi; Hitoshi Chiba; Shu-Ping Hui
  Diagnostics (Basel, Switzerland), 15, 15, 25 Jul. 2025, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Background/Objectives: Oxylipins, a family of oxygenated natural products derived from polyunsaturated fatty acids (PUFAs), play crucial roles in various physiological processes. Evaluating their levels in vivo helps to reveal their roles in health and disease. Because of the numerous isomers of oxylipins, it is essential to develop efficient and precise analytical methods for their identification and quantification. The objective of this study is to establish a quantitative method for oxylipin analysis and its application to the assessment of oxylipins in children's plasma, with potential implications for diagnostic use in pediatric populations. Methods: A liquid chromatography-electrospray ionization-tandem mass spectrometry method was developed to quantify 64 oxylipins and four precursor PUFAs within 36 min. The limits of quantification ranged from 0.25 to 50 pg, with most analytes showing recoveries and matrix effects between 85 and 110% and between 90 and 110%, respectively. Intra- and inter-day precision values were within 15%. The established method was applied to plasma samples from children aged 9-12 years (boys = 181; girls = 161) in Hokkaido, Japan, to assess the relation between plasma oxylipin and PUFA levels and age, sex, and body mass index. Results: There was no significant correlation between oxylipin levels and age, sex, or body mass index. However, among the PUFAs, boys had higher eicosapentaenoic acid and arachidonic acid levels than those of girls, with a significant increase in eicosapentaenoic acid levels in the overweight group compared with those in the underweight group. Conclusions: We successfully developed a simple and highly selective method for the analysis of oxylipins in preadolescent children's plasma samples. Thus, this study provides a foundation for broader application of the developed method to different biological samples in future studies.
• Association of Phthalate Exposure with Respiratory and Allergic Symptoms and Type 2 and Non-Type 2 Inflammation: The Hokkaido Study.
  Rahel Mesfin Ketema; Yu Ait Bamai; Houman Goudarzi; Takeshi Yamaguchi; Yi Zeng; Ayaka Yasuda; Megasari Marsela; Satoshi Konno; Reiko Kishi; Atsuko Ikeda
  Environmental science & technology, 59, 15, 7541, 7549, 22 Apr. 2025, [Peer-reviewed], [Corresponding author], [International Magazine]
  English, Scientific journal, Phthalate exposure is linked to asthma and allergic symptoms, yet their individual and combined effects on symptoms and inflammatory biomarkers, type 2 (T2) and non-T2, remain unexplored. This study examined the association of phthalate metabolites with allergic symptoms (wheeze, allergic rhinoconjunctivitis, and eczema), T2 biomarker (fraction of exhaled nitric oxide (FeNO), blood eosinophil count, and total immunoglobulin E (IgE)), and non-T2 biomarker (absolute neutrophil count (ANC)) and also their association with oxidative stress biomarkers, such as 4-hydroxynonenal, hexanoyl-lysine, and 8-hydroxy-2-deoxyguanosine. Ten urinary phthalate metabolites were measured using UPLC-MS/MS in 421 children (aged 9-12 years) from The Hokkaido Cohort, Japan. Symptoms were defined using the International Study of Asthma and Allergies in Childhood questionnaire, and biomarkers were measured in blood. Logistic regression assessed individual metabolites, while quantile-g computation and Bayesian kernel machine regression analyzed mixture effects on binary outcomes. Individual analysis showed that MnBP (mono-n-butyl phthalate) was positively associated with allergic rhinoconjunctivitis and eosinophil ≥ 300 cells/μL, while ∑DBP (dibutyl phthalate) and OH-MiNP (mono-hydroxy-isononyl phthalate) were linked with FeNO ≥ 35 ppb. DEHP (di(2-ethylhexyl) phthalate) metabolites were associated with a high prevalence of blood eosinophils ≥ 300 cells/μL. We found a positive association between phthalates and oxidative stress markers, but no link was observed between oxidative stress and inflammatory markers. Mixture analysis identified MnBP as a major contributor to the high FeNO level, with di-n-butyl phthalate (DnBP) and DEHP metabolites contributing to eosinophil count ≥ 300 cells/μL and ANC ≥ 4400 cells/μL. These findings suggest that phthalate exposure from DnBP and DEHP is associated with immune dysregulation by triggering both T2 and non-T2 inflammatory responses.
• Apolitical Science.
  Julie Beth Zimmerman; Gregory Lowry; Fernando Rosario-Ortiz; Paul Westerhoff; Daniel Alessi; Pedro Alvarez; Alexandra Boehm; Ian Cousins; Jordi Dachs; Matthew Eckelman; Imad El Haddad; Pablo Gago-Ferrero; Jorge Gardea-Torresdey; Jacqueline MacDonald Gibson; Keri Hornbuckle; Heileen Hsu-Kim; Juliane Hollender; Atsuko Ikeda; Frederic Leusch; Melissa Maurer-Jones; James Mihelcic; Shelly Miller; Lutgarde Raskin; Z Jason Ren; Susan Richardson; Daniel Schlenk; Huahong Shi; Paul Tratnyek; David Waite; Shuxiao Wang; Zhanyun Wang; Michael Wong; Sukhwan Yoon
  Environmental science & technology, 59, 13, 6355, 6356, 08 Apr. 2025, [International Magazine]
  English
• Associations between urinary phthalate metabolites and reproductive, adrenal, and gonadotropic hormones in peripubertal children: the Hokkaido study.
  Ayaka Yasuda; Yu Ait Bamai; Takeshi Yamaguchi; Rahel Mesfin Ketema; Yi Zeng; Megasari Marsela; Yoshinori Ikenaka; Akie Nakamura; Takeya Kitta; Masafumi Kon; Atsushi Manabe; Reiko Kishi; Hiroyuki Kojima; Atsuko Ikeda
  Environmental research, 121535, 121535, 03 Apr. 2025, [Peer-reviewed], [Corresponding author], [International Magazine]
  English, Scientific journal, Phthalates have raised concerns regarding the disruption of hormone synthesis and signaling. The purpose of this study was to investigate the associations between urinary phthalate metabolites and 18 hormones, including reproductive, adrenal, and gonadotropic hormones, in peripubertal children. The study comprised a cross-sectional analysis of participants in the Hokkaido Birth Cohort Study. We collected data from 429 school children aged 9-12 living in Sapporo, Japan. Ten phthalate metabolites and 14 steroid hormones were analyzed using LC-MS/MS, whereas four peptide hormones were detected using immunoassays. Multivariable linear regression, quantile-based g-computation (qg-computation), and Bayesian kernel machine regression (BKMR) were used to investigate the associations between the individual phthalate metabolites and the phthalate mixtures with hormone levels, as well as with puberty based on hormone levels. In girls, we found that higher phthalate metabolite levels, as well as phthalate mixtures, were significantly associated with lower dehydroepiandrostenedione-sulfate (DHEA-S) and higher (androstenedione + testosterone) / DHEA-S. The higher phthalate mixture showed lower levels of LH, FSH, and cortisol levels among girls, whereas higher 11-deoxycortisol levels. In boys, a higher phthalates mixture was significantly associated with a higher estradiol/testosterone ratio, whereas lower levels of insulin-like factor-3 (INSL3), testosterone, (androstenedione + testosterone)/DHEA-S, testosterone/androstenedione, and cortisol/cortisone. Higher phthalate mixtures were associated with lower prevalence of puberty in girls. These findings indicate that phthalate exposure may disrupt the hormones in children during puberty.
• Ambient formaldehyde combined with high temperature exposure and respiratory disease admissions among children: a time-series study across multiple cities.
  Yuting Cheng; Mingzhi Zhang; Hao Zheng; Qiurun Yu; Hongcheng Wei; Ruibin Xue; Shanshan Wang; Bo Hang; Atsuko Ikeda; Yuming Guo; Yankai Xia
  Thorax, 31 Mar. 2025, [Peer-reviewed], [International Magazine]
  English, Scientific journal, INTRODUCTION: Ambient formaldehyde (HCHO) is globally distributed, posing significant exposure to vast populations, particularly vulnerable demographics such as children. Investigations into the correlation between ambient HCHO exposure and children's respiratory ailments are deficient. METHODS: Ambient HCHO exposure was retrieved from the TROPOspheric Monitoring Instrument. A two-stage time-series analysis was conducted to examine the relationship between HCHO exposure and hospital admission of respiratory diseases among 198 704 children in Jiangsu Province, China, from 2019 to 2021. Additionally, 12 exposure patterns were defined to further discern potential synergistic effects of HCHO and high temperature combined exposure. RESULTS: After controlling for relevant covariates, our findings revealed HCHO exposure was associated with respiratory-related hospital admissions. Specifically, we identified a pronounced effect at lag 3 day, demonstrating a 1.14% increase (95% CI: 0.60%, 1.69%). Subgroup analyses further identified that warm season, 3-7 years old group and disadvantaged economic areas showed higher admission risk. Moreover, we found HCHO combined with high temperature exposure would trigger the elevated risk of hospital admission. Notably, in specific exposure scenarios, the cumulative relative risk reached up to 1.051 (95% CI: 1.025, 1.078), highlighting the synergistic effect of combined exposure on the respiratory health of children. CONCLUSIONS: Ambient HCHO exposure increased hospital admission risks for respiratory diseases in children, and high temperature could trigger the elevated risk. To have an in-depth understanding of ambient HCHO health impact is critical for intervention strategies aimed at mitigating ambient HCHO pollution and regarding adverse impacts on children under a changing climate.
• Phosphate Flame Retardants and Plasticizers and Their Association with Reproductive and Steroid Hormone Levels among Peripubertal-Aged Children: The Hokkaido Birth Cohort Study
  Atsuko Ikeda; Takeshi Yamaguchi; Yu Ait Bamai; Maarten Roggeman; Yoshinori Ikenaka; Yi Zeng; Ayaka Yasuda; Rahel Mesfin Ketema; Megasari Marsela; Celine Gys; Fatima den Ouden; Sachiko Itoh; Akie Nakamura; Takeya Kitta; Masafumi Kon; Atsushi Manabe; Adrian Covaci; Reiko Kishi
  Environmental Science & Technology, 18 Mar. 2025, [Peer-reviewed], [Lead author, Corresponding author]
  Scientific journal
• Application of Liquid Chromatography/Tandem Mass Spectrometry for Quantitative Analysis of Plasmalogens in Preadolescent Children—The Hokkaido Study
  Yifan Chen; Siddabasave Gowda B. Gowda; Divyavani Gowda; Jayashankar Jayaprakash; Lipsa Rani Nath; Atusko Ikeda; Yu Ait Bamai; Rahel Mesfin Ketema; Reiko Kishi; Hitoshi Chiba; Shu-Ping Hui
  Diagnostics, 16 Mar. 2025, [Peer-reviewed]
  Scientific journal
• Association between prenatal exposure to maternal metal and trace elements and Streptococcus infection: A prospective birth cohort in the Japan Environment and Children’s Study
  Hiroyoshi Iwata; Atsuko Ikeda; Mariko Itoh; Rahel Mesfin Ketema; Naomi Tamura; Takeshi Yamaguchi; Keiko Yamazaki; Rieko Yamamoto; Maki Tojo; Yu Ait Bamai; Yasuaki Saijo; Yoshiya Ito; Reiko Kishi
  PLOS ONE, 20, 2, e0319356, e0319356, Public Library of Science (PLoS), 27 Feb. 2025, [Peer-reviewed]
  Scientific journal, Background
  
  Streptococcus infection is a common and potentially severe bacterial infection which remains a global public health challenge, underscoring the necessity of investigating potential risk factors.
  
  Aims
  
  The present study aims to assess the association between metal and trace element exposure and Streptococcus infection using a prospective nationwide birth cohort, the Japan Environment and Children’s Study (JECS).
  
  Methods
  
  The JECS obtained data from over 100,000 pregnancies through 15 Regional Centres across Japan. We assessed toxic metal and trace element levels among pregnant mothers and Streptococcus infection among their children, born between 2011 and 2014, at age three to four. Analysis was performed using univariable and multivariable logistic regressions, as well as Quantile g-computation. We also conducted quartile regressions to assess the effects of higher serum selenium levels and potential interactions between selenium and mercury.
  
  Results
  
  Among 74,434 infants and their mothers, univariable and multivariable regression analyses found that selenium and mercury each had an inverse association with Streptococcus infection incidence. Quantile g-computation analysis yielded results consistent with the primary regression analyses. Quartile regression suggested that serum selenium levels above the third quartile were inversely associated with later Streptococcus infection incidence, but no interaction between selenium and mercury was found.
  
  Conclusions
  
  These findings imply that maternal selenium exposure may have protective effects on Streptococcus infection among children. Further studies should explore the role of pediatric selenium in immune responses to infectious diseases, especially Streptococcus infection.
• Comparative study on gene expression profiles in the liver of male neonatal mice prenatally exposed to PFOA and its alternative HFPO-DA.
  Wataru Murase; Atsuhito Kubota; Ryo Hakota; Ayaka Yasuda; Atsuko Ikeda; Koji Nakagawa; Ryota Shizu; Kouichi Yoshinari; Hiroyuki Kojima
  Toxicology, 511, 154048, 154048, Feb. 2025, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Hexafluoropropylene oxide dimer acid (HFPO-DA), which belongs to the class of perfluoroalkyl ether carboxylic acid (PFECA), is a new alternative to perfluorooctanoic acid (PFOA). However, whether HFPO-DA is a safer alternative to PFOA in neonates remains unclear. In this study, we evaluated neonatal hepatic toxicity on postnatal days 9-10 by orally exposing pregnant CD-1 mice to 0.3 or 3.0 mg/kg/day (low or high doses) of HFPO-DA or PFOA from gestation days 15-17. The results showed that exposure of pregnant mice to HFPO-DA and PFOA induced similar phenotypic effects, including significant decreases in neonatal body weight (BW) and significant increases in liver weight relative to BW in the high-dose. Notably, HFPO-DA exposure significantly decreased in neonatal BW in the low-dose group, whereas PFOA did not. Comprehensive gene expression analysis revealed significant alterations in 408 and 1402 differentially expressed genes (DEGs) in the liver of neonates from the low- and high-dose HFPO-DA groups, respectively, while PFOA significantly altered 0 and 292 DEGs in the corresponding groups. Gene set enrichment analysis indicated that the DEGs induced by HFPO-DA and PFOA were enriched in pathway related to "PPAR signaling", "fatty acid metabolism", and "biological oxidations". In addition, transactivation assays revealed that mouse (m)PPARα and mPPARγ activity of HFPO-DA exceeds that of PFOA and molecular docking simulations analysis predicted that the binding conformation differ between PFOA and HFPO-DA. Overall, our findings demonstrate that HFPO-DA consistently affected neonatal phenotypes, liver gene expression and the molecular initiating events involving PPARα/γ, at lower concentrations than PFOA.
• Association between children's intended screen time use and behavior problems in Japan: the Hokkaido Study on Environmental and Children's Health.
  Naomi Tamura; Keiko Yamazaki; Chihiro Miyashita; Atsuko Ikeda; Ammara Ajmal; Satoshi Suyama; Takashi Hikage; Manabu Omiya; Masahiro Mizuta; Reiko Kishi
  Environmental health and preventive medicine, 30, 82, 82, 2025, [Domestic magazines]
  English, Scientific journal, BACKGROUND: Long screen time hours may be associated with behavioral problems in children. To better understand the relationship between children's behavioral problems and screen time, it the associated risk factors must be subdivided based on the purpose underlying screen use. This study examined the relationship between screen time based on intended usage and behavioral problems in Japan. METHODS: This study included 3,332 children aged between 7-17 years from the Hokkaido Study on Environment and Children's Health. From October 2020 to October 2021, the children and their parents answered questionnaires on the children's screen use duration (never used, <30 min, ≥30 min & <1 hour, ≥1 h & <2 h, ≥2 h) based on seven intended usage categories: watching television/video, video gaming, reading books/comics, sending/receiving e-mail/messages, browsing/posting on social networking services, studying for classes/homework, drawing/editing pictures/photos/videos, along with the Strengths and Difficulties Questionnaire (SDQ). Logistic regression was used to analyze the association between screen time, purpose of children's screen use, and behavioral problems across the 13 SDQ total scores. RESULTS: The mean ± standard deviation age of the participants was 12.4 ± 2.4-years-old, 487 (14.6%) children were determined to have behavioral problems, and the duration of screen time increased with their age. The children's primary purposes for screen use were watching television/video, video gaming, sending/receiving e-mail/messages, and browsing/posting on social networking services. Children who reported playing video games for ≥2 hours on weekdays had higher odds of problematic total difficulties scores than never user (Odds Ratio: 2.10, 95% confidence interval: 1.45-3.06). CONCLUSION: Long video gaming screen time is associated with behavioral issues, hyperactivity/inattention, and prosocial behaviors in children. Conversely, watching television and videos for 30 min-1 h per day, using e-mail or messaging, and using social networking services were significantly association with reduced odds ratio for peer relationship problems as compared to children who never engaged in these activities. Longitudinal follow-up is needed to further examine screen time and problem behaviors.
• Sick building syndrome, multiple chemical sensitivity, and related factors: A cross-sectional analysis from the Japan Environment and Children's Study.
  Yasuaki Saijo; Eiji Yoshioka; Yukihiro Sato; Hiroyuki Shiotsuki; Kentaro Nakanishi; Yasuhito Kato; Ken Nagaya; Satoru Takahashi; Yoshsiya Ito; Atsuko Ikeda; Hiroyoshi Iwata; Takeshi Yamaguchi; Reiko Kishi
  PloS one, 20, 6, e0324562, 2025, [International Magazine]
  English, Scientific journal, Sick building syndrome (SBS) is caused by having unhealthy indoor environments. Multiple chemical sensitivity (MCS) is a chronic condition that is potentially triggered by low-level chemical exposure. Demographic factors, lifestyle factors, and comorbidities have been reported as potential risk factors of both conditions; however, studies on these factors involving large populations in Japan are limited. The aim of this study was to investigate whether demographics, lifestyle, and comorbidities were associated with MCS and SBS in a large Japanese population, and whether autistic traits (Japanese version of the Autism-Spectrum Quotient Short Form, AQ-10-J), psychological distress (Japanese version of the Kessler 6-Item Psychological Distress Scale, K6), and serum total and allergen-specific immunoglobulin E (IgE) levels were related to the outcomes. The participants included 92,387 pregnant women and 48,451 partners. The outcomes were self-reported physician-diagnosed SBS, MCS, and SBS and/or MCS (combined outcome [CO]). Age-adjusted odds ratios (ORs) of total and antigen-specific IgE levels, demographic factors, and lifestyle factors were determined. The proportions of pregnant women with SBS, MCS, and CO were 307 (0.33%), 128 (0.14%), and 415 (0.45%), respectively, while those of their partners were 85 (0.18%), 30 (0.06%), and 112 (0.23%), respectively. Allergic diseases, psychiatric diseases, migraine, and higher psychological distress were associated with significantly higher ORs for SBS, MCS, and CO. Among pregnant women, autoimmune diseases, cancer, kidney diseases, higher physical activity, autistic traits, and total and specific IgE levels were associated with significantly higher ORs for SBS, MCS, and CO. Clinicians should consider common comorbid disorders when treating patients with SBS and MCS, and their protective and deteriorating lifestyles and demographic factors should be clarified.
• The potential health risks of exposure to environmental chemicals - Global implications for future generations.
  Reiko Kishi; Atsuko Ikeda; Rahel Mesfin Ketema
  Proceedings of the Japan Academy. Series B, Physical and biological sciences, 101, 4, 197, 215, 2025, [Domestic magazines]
  English, Scientific journal, In 2001, we launched the Hokkaido Study, the first prospective birth cohort study in Japan. We are currently tracking the effects of environmental chemicals, using a life course approach. The study examines life circumstances after birth, and the longest follow-up to date is 20 years of age. We have measured prenatal exposure to dioxins, organochlorine pesticides, per- and polyfluoroalkyl substances, plasticizers such as di(2-ethylhexyl) phthalate, and bisphenol A. Our findings have mostly revealed that increased exposure to these environmental chemicals is linked to increased risk of lower birth size, effects on thyroid and steroid hormones, adipokine levels, as well as disruption of neurodevelopment, including causing asthma and respiratory symptoms. However, it should be noted that our findings also include protective or null findings, which may be due to low chemical concentrations or differences in prenatal or postnatal exposure. We would like to emphasize the importance of long-term continuation of the cohort, effective utilization of the data, and application of the results to environmental and health policies.
• Plasma Lipidomics of Preadolescent Children: A Hokkaido Study
  Jayashankar Jayaprakash; Siddabasave Gowda B. Gowda; Divyavani Gowda; Atsuko Ikeda; Yu Ait Bamai; Rahel Mesfin Ketema; Reiko Kishi; Yifan Chen; Hitoshi Chiba; Shu-Ping Hui
  Journal of Lipids, 2025, 3106145, 3106145, Jan. 2025, [International Magazine]
  English, Scientific journal, Lipids are the most abundant biomolecules of human plasma, and their balance plays a significant role in health and disease management. Despite the importance of lipids, the studies focused on the comprehensive determination of the plasma lipidome in children are limited. In this study, we investigated the sex, age, and weight-specific changes in the plasma lipidome of nonfasting preadolescent children aged 9-12 years (n = 342) using a nontargeted liquid chromatography-mass spectrometry technique. A total of 219 lipid species were characterized in the plasma samples. Multivariate analysis revealed that boys and girls have similar lipid profiles, but relatively higher levels of capric acid-composed triacylglycerols (TGs) were observed in plasma samples of boys. Saturated fatty acids are the most abundant fatty acyls followed by mono- and polyunsaturated fatty acids in the plasma of both boys and girls. Sphingolipids such as ceramides, hexosylceramides, sphingomyelin, and a phospholipid (phosphatidylinositol) were relatively higher in the plasma of a 10-year-old group than other age groups. Plasma levels of TG and phosphatidylserine were increased within age from 9 to 12 years. Furthermore, most of the TG molecular species were increased in the plasma of overweight children compared to the normal range groups. The receiver operating characteristic analysis results show that TG (10:0/10:0/18:1) could be a specific marker for childhood obesity (area under the curve (AUC) = 0.72). Overall, this study highlights the altered plasma lipidome in preadolescent children for sex, age, and percentage of overweight. Early detection of lipid markers for obesity would be a promising target for developing therapeutic strategies.
• Association between prenatal tobacco exposure and attention-deficit/hyperactivity disorder related characteristics at 6 and 8 years: a birth cohort in Japan
  Mariko Itoh; Sumitaka Kobayashi; Shinkichi Nishihara; Chihiro Miyashita; Keiko Yamazaki; Naomi Tamura; Satoshi Suyama; Atsuko Ikeda; Sachiko Itoh; Yu Ait Bamai; Takeshi Yamaguchi; Hideyuki Masuda; Sharon Hanley; Reiko Kishi
  BMJ Open, 14, 12, e087406, e087406, BMJ, 26 Dec. 2024, [Peer-reviewed]
  Scientific journal, Objectives
  
  To examine the association between maternal plasma cotinine concentrations during pregnancy and attention-deficit/hyperactivity disorder (ADHD) related characteristics in children.
  
  Design
  
  Prospective birth cohort study from the Hokkaido Study on Environment and Children’s Health.
  
  Setting
  
  Hokkaido, Japan.
  
  Participants
  
  A total of 7217 children were included in the analysis. Their mothers were recruited to this study between 2003 and 2012 during early pregnancy. Blood samples of mothers in their third trimester of pregnancy were obtained.
  
  Main outcome measures
  
  ADHD-related characteristics screened by the ADHD-Rating Scale (ADHD-RS) in children at 6 and 8 years of age.
  
  Results
  
  The mothers were classified into three groups according to plasma cotinine levels (median=0.22 ng/mL)—non-smokers (≤0.21 ng/mL), passive smokers (0.22–11.48 ng/mL) and active smokers (≥11.49 ng/mL). ADHD was suspected in 302 (8.6%), 334 (10.9%) and 90 (14.5%) children in the non-smoker, passive smoker and active smoker groups, respectively. Children born to mothers in the smoking group had a statistically significant increased risk of ADHD-related characteristics (adjusted RR=1.49, 95% CI=1.19–1.86 and adjusted RR=1.20, 95% CI=1.03–1.40 for the active and passive smoking groups, respectively).
  
  Conclusion
  
  This large Japanese cohort study suggests an association between smoking during pregnancy and the risk of ADHD in children 6 and 8 years of age.
• Organophosphate flame retardants associated with increased oxidative stress biomarkers and elevated FeNO levels in general population of children: The Hokkaido study.
  Yi Zeng; Yu Ait Bamai; Houman Goudarzi; Rahel Mesfin Ketema; Maarten Roggeman; Fatima den Ouden; Celine Gys; Sachiko Ito; Satoshi Konno; Adrian Covaci; Reiko Kishi; Atsuko Ikeda
  The Science of the total environment, 957, 177756, 177756, 20 Dec. 2024, [International Magazine]
  English, Scientific journal, Our previous study found that exposure to higher organophosphate flame retardants (PFRs) was associated with increased prevalence of wheeze and type 2 inflammation among school-aged children. It remains unclear whether PFR exposure elevates oxidative stress in these general pediatric population, thereby potentially contributing to the development of allergic diseases. This study examined the associations between individual and mixture exposure to PFRs and oxidative stress in children aged 9-12 years (n = 423). The oxidative stress biomarkers included 4-hydroxynonenal (4-HNE) and hexanoyl-lysine (HEL) for lipid peroxidation, and 8-hydroxy-2'-deoxyguanosine (8-OHdG) for DNA damage. We also examined the mediation effects of oxidative stress on the relationships between PFR exposure and health outcomes: wheeze and type 2 inflammation biomarkers, including fraction of exhaled nitric oxide (FeNO) and blood eosinophils. Higher concentrations of tris(1,3-dichloro-2-propyl) phosphate (TDCIPP), Σ triphenyl phosphate (ΣTPHP), Σ tris(2-butoxyethyl) phosphate (ΣTBOEP), and Σ 2-Ethylhexyldiphenyl phosphate (ΣEHDPHP) metabolites were significantly associated with higher levels of 4-HNE. Elevated concentrations of TDCIPP, ΣTPHP, and ΣTBOEP were positively associated with HEL. Higher ΣTPHP and ΣTBOEP were positively associated with 8-OHdG. The PFR mixture was positively associated with all three oxidative stress biomarkers according to the Quantile g-computation and Bayesian kernel machine regression models. Oxidative stress biomarkers mediated 11.4 % to 15.3 % of the association between PFRs and FeNO ≥35 ppb. PFR exposure was positively associated with oxidative stress markers of DNA damage and lipid peroxidation, which may contribute to elevated type 2 inflammation among school-aged children. These findings, identified in the general pediatric population at low exposure levels, highlight the need for ongoing attention to the allergic symptoms posed by PFR exposure.
• Developing and testing a draft scale evaluating older adults' perceptions of community-based connectedness with people: A pilot study.
  Mami Kikuchi; Atsuko Ikeda; Michiyo Hirano
  [Nihon koshu eisei zasshi] Japanese journal of public health, 18 Dec. 2024, [Peer-reviewed], [Domestic magazines]
  English, Scientific journal, Objective Connectedness is essential for maintaining the physical and mental health of older adults. However, measurements that consider the presence of community-dwelling people and explicitly focus on an individual's subjective sense of connectedness have not yet been established. This pilot study aimed to develop a draft scale that comprehensively measured older adults' perceptions of community-based connectedness with people.Methods The scale development comprised three phases; item review, pre-test, and field verification. Phase 1 (item review) involved creating an item pool and evaluating content validity. Phase 2 (pretest) involved evaluating face validity and conducting item analysis on the preliminary version of the scale. Phase 3 (field verification) involved distributing the preliminary scale to 800 Japanese men and women aged ≥ 65 years residing in Asahikawa, Hokkaido, Japan. Validity was assessed by factorial validity using exploratory factor analysis and concurrent validity using correlation analysis. Reliability was confirmed by Cronbach's α coefficient using the internal consistency method.Results The evaluation of content validity in Phase 1 and face validity in Phase 2 yielded 30 items. In phase 3, of the 800 questionnaires that were distributed, 343 were returned, of which 309 included responses to all items and were analyzed. Exploratory factor analysis resulted in a 22-item scale comprising three factors that assessed perceptions of community-based connectedness. The Cronbach's α for the total scale was 0.967, and the α coefficients for inclusion, reciprocity through provision, and reciprocity through reception were 0.941, 0.915, and 0.928, respectively. The total scale scores were significantly positively correlated with purpose in life (rs = .453, P < .001) and negatively correlated with loneliness (rs = -.307, P < .001).Conclusion The 22-item draft scale exhibited adequate reliability and validity. Perceptions of connectedness measured by this scale can be used to support public healthcare interventions for community-dwelling older adults.
• Our Selections for the Best ES&T Letters Papers in 2023
  Bryan W. Brooks; William A. Arnold; Alexandria B. Boehm; Imad El Haddad; Atsuko Ikeda; Jonathan W. Martin; James R. Mihelcic; Margaret Mills; Z. Jason Ren; Daniel Schlenk; Huahong Shi; Shuxiao Wang; Zhanyun Wang
  Environmental Science & Technology Letters, 10 Dec. 2024, [Peer-reviewed]
  Scientific journal
• Effects of di-(2-ethylhexyl) phthalate and its metabolites on transcriptional activity via human nuclear receptors and gene expression in HepaRG cells
  Ayaka Yasuda; Wataru Murase; Atsuhito Kubota; Naoto Uramaru; Katsuhiro Okuda; Ryo Hakota; Atsuko Ikeda; Hiroyuki Kojima
  Toxicology in Vitro, 101, 105943, 105943, Elsevier BV, Dec. 2024, [Peer-reviewed]
  Scientific journal
• Impact of wheat sensitization on wheeze and T2 phenotypes in general population of children
  Houman Goudarzi; Atsuko Ikeda; Yu Ait Bamai; Isao Yokota; Chihiro Miyashita; Wilfried Karmaus; Reiko Kishi; Satoshi Konno
  Journal of Allergy and Clinical Immunology: Global, 3, 4, Nov. 2024, [Peer-reviewed]
  Scientific journal
• Determination of plasma lysophosphatidylethanolamines (lyso-PE) by LC-MS/MS revealed a possible relation between obesity and lyso-PE in Japanese preadolescent children: the Hokkaido study.
  Nao Inoue; Siddabasave Gowda B Gowda; Divyavani Gowda; Toshihiro Sakurai; Atsuko Ikeda-Araki; Yu Ait Bamai; Rahel Mesfin Ketema; Reiko Kishi; Hitoshi Chiba; Shu-Ping Hui
  Annals of clinical biochemistry, 45632241280352, 45632241280352, 21 Aug. 2024, [Peer-reviewed], [International Magazine]
  English, Scientific journal, BACKGROUND: Lysophosphatidylethanolamines (lyso-PEs) are the partial hydrolysis products of phosphatidylethanolamine. Although lyso-PEs are important biomarkers in various diseases, their determination is limited by the lack of simple and efficient quantification methods. This study aims to develop an improved quantitative method for the determination of lyso-PEs and its application to an epidemiological study. METHODS: Single reaction monitoring channels by collision-induced dissociation for seven lyso-PEs were established using liquid chromatography-tandem mass spectrometry. Plasma lyso-PEs were extracted with a single-phase method using an isotopically labeled internal standard for quantification. The proposed method was adopted to define lyso-PEs in plasma samples of children aged 9-12 years living in Sapporo, Japan. RESULTS: The limit of detection and limit of quantification for each lyso-PE ranged between 0.001-0.015 and 0.002-0.031 pmol/μL, respectively. Recoveries were found to be > 91% for all the species. The analysis results of children's plasma showed that the total lyso-PE concentrations in boys (n = 181) and girls (n = 161) were 11.53 and 11.00 pmol/μL (median), respectively. Participants were further classified by the percentage of overweight and subgrouped as underweight (n = 12), normal range (n = 292), or overweight (n = 38). Interestingly, the reduction of lyso-PE 16:0 and increased lyso-PE 22:6 were observed in overweight children compared with normal range (Fold change: 0.909 and 1.174, respectively). CONCLUSIONS: This study successfully established a simple quantitative method to determine lyso-PE concentrations. Furthermore, our method revealed the possible relation between plasma lyso-PEs and overweight status.
• Quantitative determination of plasma cholesteryl ester levels in Japanese preadolescents from the Hokkaido study using liquid chromatography/tandem mass spectrometry.
  Divyavani Gowda; Siddabasave Gowda B Gowda; Atsuko Ikeda; Rahel Mesfin Ketema; Yu Ait Bamai; Reiko Kishi; Hitoshi Chiba; Shu-Ping Hui
  Steroids, 211, 109498, 109498, 13 Aug. 2024, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Cholesteryl esters (CE) are sterols comprising various fatty acyl chains attached to a cholesterol hydroxyl moiety. CEs are often considered plasma biomarkers of liver function; however, their absolute concentrations in the plasma of Japanese preadolescents have not been well explored. This study aimed to determine the plasma CE levels in Japanese preadolescents of different sexes, ages, and body weights living in Hokkaido, Japan using targeted liquid chromatography/tandem mass spectrometry. The analysis was performed on the non-fasting plasma of preadolescents aged 9-12 years (n = 339 healthy volunteers; 178 boys and 161 girls) from Sapporo, Hokkaido, Japan. The analysis results showed that the total CE levels in boys and girls were 871 ± 153 and 862 ± 96 pmol/μL, respectively. CE 18:2 (41 ± 2.9 %) was found to be the most abundant species followed by CE 18:1 (16 ± 1.5 %) and CE 16:0 (13 ± 1.1 %). The ω-3 fatty acid-containing CEs such as CE 18:3 and CE 20:5 were significantly lower in girls than in boys. Despite the different ages, CEs were tightly regulated in the plasma of children's, and the total CEs ranged between 844 and 906 pmol/μL in boys and 824 and 875 pmol/μL in girls. The participants were further classified into three groups based on their body mass index underweight (n = 237), normal weight (n = 94), and overweight (n = 8). Most of the quantified CEs were accumulated in the overweight group. Interestingly, CE 18:3 was significantly upregulated in the overweight group compared to that in the normal range, and the area under the receiver operating characteristic curve was 0.73, suggesting that it could be a possible marker for obesity. This study marks the initial investigation of absolute CE levels in the plasma of children and can help elucidate the relationship between CEs and childhood obesity.
• Link between Wi-Fi, cordless devices, mobile phone usage patterns, and behavioral problems among Japanese children: A prospective cohort study.
  Ammara Ajmal; Keiko Yamazaki; Naomi Tamura; Yu Ait Bamai; Toshio Yoshikawa; Takashi Hikage; Atsuko Ikeda; Reiko Kishi
  Environmental research, 261, 119715, 119715, 02 Aug. 2024, [Peer-reviewed], [International Magazine]
  English, Scientific journal, BACKGROUND: With the recent advent of technology, it is important to confirm the health and safety of the youth. This study aimed to prospectively evaluate the relationship between Wi-Fi, cordless phones, and mobile phone usage patterns and behavioral problems. METHODS: This study involved 2465 children aged 8-17 years from the Hokkaido Study on Environment and Children's Health from October 2020 to January 2021, with a follow-up from September 2021 to March 2022. The mother-child dyad provided information on the presence of residential Wi-Fi and cordless phones, cordless phone call duration, and mobile phone usage pattern (duration of calls using mobile network and internet, online audio streaming, online video streaming, and playing online games) via a baseline questionnaire. Based on the scores on Strength and Difficulties Questionnaire at baseline and follow-up, the children were categorized into four groups: normal, persistent, improved, and concurrent. RESULTS: No significant association was found between Wi-Fi, mobile phone calls via mobile networks, and behavioral problems. Cordless phone at home had higher odds for improvement in total difficulty scores, and cordless phone for calling more than 4 min per week had lower odds of persistent problematic prosocial behavior. Longer duration of mobile phone calling via the internet (>40 min/week) had higher odds of concurrent total difficulties. Mobile phone calling via mobile network for <5 min per week had higher odds for improved total difficulty scores. Audio streaming via mobile phones for 60-120 min had lower odds of persistent total difficulties. CONCLUSION: Our results showed sporadic findings between residential RF-EMF indoor sources and mobile phone usage pattern. These observed findings could be affected by residual confounding and chance findings. Ongoing follow-up studies are necessary to further explore this association through detailed exposure assessment and addressing the potential limitations of our study.
• Night shift work and female breast cancer: a two-stage dose-response meta-analysis for the correct risk definition.
  Jinyoung Moon; Atsuko Ikeda-Araki; Yongseok Mun
  BMC public health, 24, 1, 2065, 2065, 31 Jul. 2024, [International Magazine]
  English, Scientific journal, INTRODUCTION: The hypothesis of this study is night shift work exposure can increase the risk of female breast cancer. To validate this hypothesis, the authors conducted a two-stage dose-response meta-analysis with improved quality on this topic. METHODS: The medical librarian searched PubMed, EMBASE, and the Cochrane Library on December 30th, 2022. The eight inclusion criteria were determined and strictly applied to the selection process. A reliable dose-response meta-analysis methodology was applied. RESULTS: Reliable 10 cohort (total cases: 15,953, and total person-years: 6,812,138) and 11 case-control reports (total cases: 9196, and total controls:12,210) were included in the final analysis. The pooled risk ratio (RR) of female breast cancer (from cohort studies) for 1, 10, 20, and 30 years of night shift work exposure was 1.0042 (95% CI 1.0014-1.0070), 1.0425 (95% CI 1.0138-1.0719), 1.0867 (95% CI 1.0278-1.1490), and 1.1328 (95% CI 1.0419-1.2317), respectively. The pooled odds ratio (OR) of female breast cancer (from case-control studies) for 1, 10, 20, and 30 years of night shift work exposure was 1.0213 (95% CI 1.0108-1.0319), 1.2346 (95% CI 1.1129-1.3695), 1.5242 (95% CI 1.2386-1.8756), and 1.8817 (95% CI 1.3784-2.5687), respectively. DISCUSSION: This study has several strengths from the perspective of a dose-response meta-analysis: Strictly applied eight inclusion criteria, separately synthesized RRs from cohort studies and ORs from case-control studies, clearly defined exposure dose, years of night shift work for each risk estimate, a reliable dose-response meta-analysis methodology, and careful considering of selection, exposure, and outcome biases and confounder adjustment for each study. This careful consideration of potential biases and confounding led to the exclusion of unreliable two cohort and five case-control studies.
• Alterations in plasma short-chain fatty acids in preadolescence children: The Hokkaido study.
  Yonghan Li; Siddabasave Gowda B Gowda; Divyavani Gowda; Atsuko Ikeda; Yu Ait Bamai; Rahel Mesfin Ketema; Reiko Kishi; Hitoshi Chiba; Shu-Ping Hui
  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1242, 124191, 124191, 15 Jul. 2024, [Peer-reviewed], [International Magazine]
  English, Scientific journal, The purpose of this study is to explore the plasma short-chain fatty acid (SCFA) concentrations in 9-12-year-old Japanese children collected in the Hokkaido study, focusing on how factors such as age, sex, and body mass index (BMI) correlate with these levels. The Hokkaido Study on Children's Health is an ongoing longitudinal study since 2002, encompassing 20,926 pregnant women in Hokkaido Prefecture, Japan, between 2003 and 2012. We contacted 1881 children aged 9-12 born between April 2006 and January 2010, and 342 non-fasting plasma samples (boys = 181, girls = 161) were obtained from this cohort, alongside assessments of their height and weight. Plasma SCFA concentrations were determined using N,N-dimethylethylenediamine derivatization method coupled with liquid chromatography-mass spectrometry. Ethyl acetate was used to extract SCFAs from plasma, and the recovery ranged from 83 % to 108 %. Our findings indicate that acetic acid had the highest concentration across all age groups and sexes. The concentrations of butyric acid, valeric acid, and hexanoic acid increased with age, peaking in 12-year-old children. Conversely, the level of 4-hydroxy valeric acid showed a decreasing trend with increasing age groups. This study also explored the correlation between BMI and SCFA concentrations, comparatively higher level of propionic acid was observed in the overweight group. The results obtained in this study enhance our understanding of the role of SCFAs in the growth and development of children and provide a foundation for future nutritional intervention and health promotion strategies.
• Prenatal risk factors of indoor environment and incidence of childhood eczema in the Japan Environment and Children's Study
  Yu Ait Bamai; Chihiro Miyashita; Atsuko Ikeda; Keiko Yamazaki; Sumitaka Kobayashi; Sachiko Itoh; Yasuaki Saijo; Yoshiya Ito; Eiji Yoshioka; Yukihiro Sato; Reiko Kishi; Michihiro Kamijima; Shin Yamazaki; Yukihiro Ohya; Nobuo Yaegashi; Koichi Hashimoto; Chisato Mori; Shuichi Ito; Zentaro Yamagata; Hidekuni Inadera; Takeo Nakayama; Tomotaka Sobue; Masayuki Shima; Hiroshige Nakamura; Narufumi Suganuma; Koichi Kusuhara; Takahiko Katoh
  Environmental Research, Jul. 2024, [Peer-reviewed]
  Scientific journal
• 口唇口蓋裂を有する1歳児の下気道感染症罹患リスク エコチル調査より
  佐藤 遊洋; 吉岡 英治; 西條 泰明; 宮本 敏伸; 東 寛; 棚橋 祐典; 伊藤 善也; 小林 澄貴; 湊屋 街子; アイツバマイ ゆふ; 山崎 圭子; 伊藤 佐智子; 宮下 ちひろ; 池田 敦子; 岸 玲子
  日本衛生学雑誌, 79, Suppl., S239, S239, (一社)日本衛生学会, Mar. 2024
  Japanese
• 日常環境における中間周波数電磁波ばく露および携帯電話等デバイスの使用と子どもの健康の関連
  山崎 圭子; 池田 敦子; 日景 隆; 岸 玲子
  北海道公衆衛生学雑誌, 37, 2, 5, 8, 北海道公衆衛生学会, Mar. 2024
  Japanese
• Development of Older Adults' Perceptions on Community-based Connectedness with People Scale: Reliability and validity evaluation.
  Mami Kikuchi; Atsuko Ikeda; Michiyo Hirano
  Japan journal of nursing science : JJNS, e12583, 12 Jan. 2024, [Peer-reviewed], [Domestic magazines]
  English, Scientific journal, AIM: We developed a self-assessment scale-Older Adults' Perceptions of Community-based Connectedness with People-to assess older adults' comprehensive perceptions of their connectedness with others in the community. A specific aim of this study is to evaluate the reliability and validity of this scale. METHODS: Participants consisted of 1000 men and women aged 65 years or older, living in Sapporo, Hokkaido, Japan. Factorial validity was assessed using exploratory and confirmatory factor analysis, while concurrent validity was assessed using correlation analysis. Reliability was confirmed by Cronbach's α coefficient using the internal consistency method, and the stability coefficient was confirmed using the test-retest method. RESULTS: Responses were received from 380 participants, and 358 participants who responded to all items were included in the analysis. The developed scale comprised 22 items with three factors: "Perception of Inclusion" (α = .947), "Perception of Reciprocity through Reception" (α = .937), and "Perception of Reciprocity through Provision" (α = .910). Correlation analyses indicated that concurrent scales were positively correlated with Ikigai and negatively correlated with loneliness on the total scale. The model fit was comparative fit index = 0.933, goodness-of-fit index = 0.854, adjusted goodness-of-fit index = 0.818, and root mean square of approximation = 0.081. The stability coefficient of the total scale scores was 0.875 (95% CI: [0.830, 0.908]). CONCLUSIONS: The developed scale had adequate reliability and validity. The perceptions of connectedness measured using this scale can be used by public health and nursing care professionals to prevent loneliness and isolation among older adults living in the community.
• Heavy metals and trace elements in maternal blood and prevalence of congenital limb abnormalities among newborns: the Japan Environment and Children's Study.
  Atsuko Ikeda; Megasari Marsela; Chihiro Miyashita; Takeshi Yamaguchi; Yasuaki Saijo; Yoshiya Ito; Hiroyoshi Iwata; Sachiko Itoh; Mariko Itoh; Keiko Yamazaki; Naomi Tamura; Sumitaka Kobayashi; Reiko Kishi
  Environmental health and preventive medicine, 29, 36, 36, 2024, [Peer-reviewed], [Lead author, Corresponding author], [Domestic magazines]
  English, Scientific journal, BACKGROUND: Heavy metals such as lead (Pb) and cadmium (Cd) have been associated with adverse pregnancy and developmental outcomes, including congenital abnormalities. This study investigated the association between exposure to heavy metals and trace elements during fetal life and congenital limb abnormalities in infants. METHODS: This study is based on a prospective ongoing nationwide birth cohort from the Japan Environment and Children's Study (JECS). The concentrations of Cd, Pb, mercury (Hg), selenium (Se), and manganese (Mn) were measured in maternal blood collected during the mid-late trimesters. Inclusion criteria were available from questionnaires filled in during pregnancy, including information about congenital limb abnormalities at birth or at one month. To examine the associations with limb anomalies and individual chemicals, logistic regression models were applied following log-transformation or division into quartiles of Cd, Pb, Hg, Se, and Mn concentrations. To assess the associations with the heavy metals and trace elements mixture, quantile g-computation was employed. All models were adjusted for age, maternal smoking history, maternal alcohol intake, history of smoking, and infant sex. RESULTS: Data from 90,163 participants were included in the analysis, of whom 369 had congenital limb abnormalities in any of the collected information, and 89,794 had none. Among the 369 cases of congenital limb abnormalities, there were 185 and 142 cases of polydactyly and syndactyly, respectively. The median concentrations of Pb, Cd, Hg, Se, and Mn were 5.85, 0.66, 3.64, 168, and 15.3 ng/g, respectively. There were no associations between maternal blood concentrations of Pb [adjusted odd ratio = 0.83; 95% confidence interval = 0.61, 1.11], Cd [0.87; 0.68, 1.10], Hg [0.88; 0.73, 1.07], Se [1.07; 0.44, 2.59], and Mn [0.91; 0.64, 1.30] with congenital limb abnormalities. No significant association was observed between the mixture of heavy metals and trace elements [0.85; 0.72, 1.02] and any congenital limb abnormalities. Moreover, there was no association with all polydactylies and all syndactylies, or any type of abnormality as a subdivision. CONCLUSION: At the maternal exposure levels of Cd, Pb, Hg, Se, and Mn assessed in the present study, no association was identified with the risk of developing congenital limb abnormalities in children.
• The association between flooring materials and childhood asthma: A prospective birth cohort in the Japan Environment and Children's Study.
  Hiroyoshi Iwata; Atsuko Ikeda; Mariko Itoh; Sachiko Itoh; Rahel Mesfin Ketema; Naomi Tamura; Chihiro Miyashita; Takeshi Yamaguchi; Keiko Yamazaki; Rieko Yamamoto; Maki Tojo; Yasuaki Saijo; Yoshiya Ito; Reiko Kishi
  PloS one, 19, 7, e0305957, 2024, [Peer-reviewed], [International Magazine]
  English, Scientific journal, BACKGROUND: Childhood asthma is known to be affected by a range of factors, including conditions in the indoor environment. While flooring material influences indoor air conditions, the potential association between flooring materials and childhood asthma remains poorly understood in Japan. OBJECTIVE: The present study aims to assess the association between childhood asthma incidence and the primary flooring material with the ongoing prospective nationwide birth cohort data of the Japan Environment and Children's Study (JECS). METHODS: The JECS gathered data on mothers and children through 15 Regional Centres across Japan. The present study assessed flooring materials used in the home and asthma incidence at age four among children born between 2011 and 2014. We implemented logistic regressions, setting asthma incidence among the children as the outcome and home floor type as the exposure. Additional analyses were conducted, stratifying the home's age as a proxy for tatami age, to assess whether the potential effect of tatami flooring on asthma risk is influenced by its age. RESULTS: The present study included total of 75,629 infants. For tatami flooring, the main multivariable regression and additional sub-group regression for homes over ten years old produced odds ratios of 1.09; 95% Confidence Interval (CI) [1.01-1.17] and 1.10; 95% CI [1.00-1.21] compared with flooring, respectively. CONCLUSION: These results imply that exposure to tatami flooring, particularly in older homes, may be associated with childhood asthma incidence. Moreover, our study highlights the importance of evaluating the relationship between regional and cultural differences between asthma and flooring materials.
• Contributions of the light environment and co-sleeping to sleep consolidation into nighttime in early infants: A pilot study.
  Michiko Yoshida; Atsuko Ikeda; Hiroyuki Adachi
  Early human development, 189, 105923, 105923, 22 Dec. 2023, [Peer-reviewed], [International Magazine]
  English, Scientific journal, BACKGROUND: Sleep consolidation into nighttime is considered the primary goal of sleep development in early infants. However, factors contributing to sleep consolidation into nighttime remain unclear. AIM: To clarify the influences of the light environment and nighttime co-sleeping on sleep consolidation into nighttime in early infants. STUDY DESIGN: Cross-sectional study. SUBJECTS AND METHODS: Sleep-wake time and light stimulation were measured in infants for 4 consecutive days using actigraphy. The infants' mothers were asked to complete a sleep events diary and a questionnaire about childcare, including "co-sleeping", defined as when the infant and mother slept on the same surface throughout the night. OUTCOME MEASURES: The data were analyzed with a focus on daytime and nighttime sleep parameters. RESULTS: Daytime light stimulation reduced daytime "active sleep", tended to reduce daytime sleep, and increased daytime waking. Nighttime light stimulation reduced nighttime "quiet sleep" and nighttime sleep and increased nighttime waking. Co-sleeping reduced nighttime waking, and, as a result, nighttime sleep time and sleep efficiency increased. Co-sleeping reduced daytime sleep and tended to increase daytime waking. Consequently, co-sleeping tended to increase the ratio of nighttime sleep to daytime sleep. CONCLUSIONS: The present findings suggest that an appropriate light environment promotes daytime waking and nighttime sleep in early infants, but it does not contribute to sleep consolidation into nighttime by itself. On the other hand, co-sleeping may promote sleep consolidation into nighttime. Therefore, further methods for safe co-sleeping need to be established while avoiding risk factors for sudden unexpected death in infancy/sudden infant death syndrome.
• Mitochondrial DNA copy number variation across three generations: a possible biomarker for assessing perinatal outcomes.
  Hisanori Fukunaga; Atsuko Ikeda
  Human genomics, 17, 1, 113, 113, 15 Dec. 2023, [Peer-reviewed], [International Magazine]
  English, Scientific journal, BACKGROUND: Mitochondria have their own circular multi-copy genome (mtDNA), and abnormalities in the copy number are implicated in mitochondrial dysfunction, which contributes to a variety of aging-related pathologies. However, not much is known about the genetic correlation of mtDNA copy number across multiple generations and its physiological significance. METHODS: We measured the mtDNA copy number in cord blood or peripheral blood from 149 three-generation families, specifically the newborns, parents, and grandparents, of 149 families, totaling 1041 individuals. All of the biological specimens and information were provided by the Tohoku Medical Megabank Project in Japan. We also analyzed their maternal factors during pregnancy and neonatal outcomes. RESULTS: While the maternal peripheral blood mtDNA copy number was lower than that of other adult family members, it was negatively correlated with cord blood mtDNA copy number in male infants. Also, cord blood mtDNA copy numbers were negatively correlated with perinatal outcomes, such as gestation age, birth weight, and umbilical cord length, for both male and female neonates. Furthermore, the mtDNA copy number in the infants born to mothers who took folic acid supplements during pregnancy would be lower than in the infants born to mothers who did not take them. CONCLUSIONS: This data-driven study offers the most comprehensive view to date on the genetic and physiological significance of mtDNA copy number in cord blood or peripheral blood taken from three generations, totaling more than 1000 individuals. Our findings indicate that mtDNA copy number would be one of the transgenerational biomarkers for assessing perinatal outcomes, as well as that appropriate medical interventions could improve the outcomes via quantitative changes in mtDNA.
• Airborne microplastics: A narrative review of potential effects on the human respiratory system.
  Udomratana Vattanasit; Jira Kongpran; Atsuko Ikeda
  The Science of the total environment, 904, 166745, 166745, 15 Dec. 2023, [Peer-reviewed], [International Magazine]
  English, Scientific journal, There has been growing evidence showing the widespread of airborne microplastics (AMPs) in many regions of the world, raising concerns about their impact on human health. This review aimed to consolidate recent literature on AMPs regarding their physical and chemical characteristics, deposition in the human respiratory tract, translocation, occurrence from human studies, and toxic effects determined in vitro and in vivo. The physical characteristics influence interactions with cell membranes, cellular internalization, accumulation, and cytotoxicity resulting from cell membrane damage and oxidative stress. In addition, prolonged exposure to AMP-associated toxic chemicals might lead to significant health effects. Most toxicological assessments of AMPs in vitro and in vivo have demonstrated that oxidative stress and inflammation are major mechanisms of action for their toxic effects. Elevated reactive oxygen species production could lead to mitochondrial dysfunction, inflammatory responses, and subsequent apoptosis in experimental models. To date, there has been some evidence suggesting exposure in humans. However, the data are still insufficient, and adverse human health effects need to be investigated. Future research on the existence, exposure, and health effects of AMPs is required for developing preventive and mitigation measures to protect human health.
• Accelerating Environmental Research to Achieve Sustainable Development Goals.
  James R Mihelcic; Ricardo O Barra; Bryan W Brooks; Miriam L Diamond; Matthew J Eckelman; Jacqueline MacDonald Gibson; Sunny Guidotti; Atsuko Ikeda-Araki; Manish Kumar; Ynoussa Maiga; Jennifer McConville; Shelly L Miller; Valeria Pizarro; Fernando Rosario-Ortiz; Shuxiao Wang; Julie B Zimmerman
  Environmental science & technology, 57, 45, 17167, 17168, 14 Nov. 2023, [International Magazine]
  English
• 北海道スタディ、思春期小児調査からみえる、将来的なNon-communicable Diseasesリスク
  山口 健史; 曾 怡; 池田 敦子; Ketema Rahel Mesfin; アイツバマイ ゆふ; 宮下 ちひろ; 池中 良徳; 今 雅史; 中村 明枝; 岸 玲子
  北海道公衆衛生学雑誌, 37, 1特別付録, 26, 26, 北海道公衆衛生学会, Nov. 2023
  Japanese
• 研究プロトコール発表 北海道の小学校6年生におけるエキノコックス症抗体保有率の調査
  岩田 啓芳; 山口 健史; 田村 菜穂美; 山本 理恵子; 東條 真希; 伊藤 真利子; 山崎 圭子; 宮下 ちひろ; 伊藤 佐智子; Ketema Rahel; 池田 敦子; 村林 宏; 伊藤 善也; 野中 成晃; 岸 玲子
  北海道公衆衛生学雑誌, 37, 1特別付録, 44, 44, 北海道公衆衛生学会, Nov. 2023
  Japanese
• Exposure to organophosphate flame retardants and plasticizers is positively associated with wheeze and FeNO and eosinophil levels among school-aged children: The Hokkaido study.
  Yi Zeng; Houman Goudarzi; Yu Ait Bamai; Rahel Mesfin Ketema; Maarten Roggeman; Fatima den Ouden; Celine Gys; Chihiro Miyashita; Sachiko Ito; Satoshi Konno; Adrian Covaci; Reiko Kishi; Atsuko Ikeda-Araki
  Environment international, 181, 108278, 108278, Nov. 2023, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, Exposure to organophosphate flame retardants and plasticizers (PFRs) increases the risk of asthma and allergies. However, little is known about its association with type 2 inflammation (T2) biomarkers used in the management of allergies. The study investigated associations among urinary PFR metabolite concentrations, allergic symptoms, and T2 biomarkers. The data and samples were collected between 2017 and 2020, including school children (n = 427) aged 9-12 years living in Sapporo City, Japan, among the participants of "The Hokkaido Study on Environment and Children's Health." Thirteen urinary PFR metabolites were measured by LC-MS/MS. Allergic symptoms were assessed using the International Study of Asthma and Allergies in Childhood questionnaire. For T2 biomarkers, the peripheral blood eosinophil counts, fraction of exhaled nitric oxide level (FeNO), and serum total immunoglobulin E level were measured. Multiple logistic regression analysis, quantile-based g-computation (qg-computation), and Bayesian kernel machine regression (BKMR) were used to examine the associations between the health outcomes of the individual PFRs and the PFR mixtures. The highest concentration of PFR was Σtris(1-chloro-isopropyl) phosphates (ΣTCIPP) (Median:1.20 nmol/L). Tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) was significantly associated with a high odds ratio (OR, 95%CI:1.36, 1.07-1.72) for wheeze. TDCIPP (OR, 95%CI:1.19, 1.02-1.38), Σtriphenyl phosphate (ΣTPHP) (OR, 95%CI:1.81, 1.40-2.37), and Σtris(2-butoxyethyl) phosphate (ΣTBOEP) (OR, 95%:1.40, 1.13-1.74) were significantly associated with increased odds of FeNO (≥35 ppb). ΣTPHP (OR, 95%CI:1.44, 1.15-1.83) was significantly associated with high eosinophil counts (≥300/μL). For the PFR mixtures, a one-quartile increase in all PFRs (OR, 95%CI:1.48, 1.18-1.86) was significantly associated with high FeNO (≥35 ppb) in the qg-computation model. The PFR mixture was positively associated with high FeNO (≥35 ppb) and eosinophil counts (≥300/μL) in the BKMR models. These results may suggest that exposure to PFRs increases the probability of asthma, allergies, and T2 inflammation.
• Cord blood triglyceride and total cholesterol in preterm and term neonates: reference values and associated factors from the Japan Environment and Children's Study.
  Hayato Go; Koichi Hashimoto; Hajime Maeda; Kei Ogasawara; Yohei Kume; Tsuyoshi Murata; Akiko Sato; Yuka Ogata; Kosei Shinoki; Hidekazu Nishigori; Atsuko Ikeda-Araki; Keiya Fujimori; Seiji Yasumura; Mitsuaki Hosoya
  European journal of pediatrics, 182, 10, 4547, 4556, Oct. 2023, [International Magazine]
  English, Scientific journal, This study aimed to investigate the associations between cord serum total cholesterol (TC) and triglyceride (TG)levels and perinatal factors and determine the reference levels of cord blood TC and TG in Japanese neonates. This was a prospective birth cohort study using data from the Japan Environment and Children's Study, which included data on births from 2011 to 2014 in Japan. TC and TG levels were determined in cord blood samples. A total of 70,535 pairs of neonates (male: 36,001, female: 34,524) and mothers were included. The mean cord blood TC and TG levels were 72.2 mg/dL and 24.4 mg/dL, respectively. Multiple regression analyses revealed that gestational age and birth weight were significantly associated with cord blood TC (coefficient -2.35, 95% confidence interval [CI] -2.40 - -2.22 and coefficient 0.002, 95% CI 0.002-0.003, respectively) and TG (coefficient 3.09, 95% CI 3.01-3.17 and coefficient - 0.009, 95% CI - 0.009-0.008, respectively) levels. Mean cord blood TG and TC levels decreased over the preterm period; however, these parameters increased during the term. Furthermore, the mean cord blood TC and TG levels decreased over the entire range of birth weight categories.    Conclusion: Mean cord blood TG and TC levels decreased over the preterm period; however, these parameters increased during the term. Furthermore, the mean cord blood TC and TG levels decreased over the entire range of birth weight categories in Japanese newborns. Maternal complications such as maternal parity, HDP, PROM, maternal obesity and income level were associated with cord TC and TG levels. What is Known: • No studies have ascertained the reference levels of cord blood lipid levels in Japan. What is New: • Mean cord blood TG and TC levels decreased over the preterm period; however, these parameters increased during the term.
• Exposure Trends to the Non-phthalate Plasticizers DEHTP, DINCH, and DEHA in Children from 2012 to 2017: The Hokkaido Study.
  Rahel Mesfin Ketema; Monika Kasper-Sonnenberg; Yu Ait Bamai; Chihiro Miyashita; Holger M Koch; Claudia Pälmke; Reiko Kishi; Atsuko Ikeda
  Environmental science & technology, 57, 32, 11926, 11936, 15 Aug. 2023, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, Phthalates owing to their endocrine-disrupting effects are regulated in certain products, leading to their replacement with substitutions such as di-2-ethylhexyl terephthalate (DEHTP), 1,2-cyclohexane dicarboxylic acid di(isononyl) ester (DINCH), and di(2-ethylhexyl) adipate (DEHA). However, information on human exposure to these substitutes, especially in susceptible subpopulations such as children, is limited. Thus, we examined the levels and exposure trends of DEHTP, DINCH, and DEHA metabolites in 7 year-old Japanese school children. In total, 180 urine samples collected from 2012 to 2017 were used to quantify 10 DEHTP, DINCH, and DEHA metabolites via isotope dilution liquid chromatography with tandem mass spectrometry. DEHTP and DINCH metabolites were detected in 95.6 and 92.2% of the children, respectively, and DEHA was not detected. This study, annually conducted between 2012 and 2017, revealed a significant (p < 0.05) 5-fold increase in DEHTP metabolites and a 2-fold increase in DINCH metabolites. However, the maximum estimated internal exposures were still below the health-based guidance and toxicological reference values. Exposure levels to DEHTP and DINCH have increased considerably in Japanese school children. DEHA is less relevant. Future studies are warranted to closely monitor the increasing trend in different aged and larger populations and identify the potential health effects and sources contributing to increasing exposure and intervene if necessary.
• Effects of perfluorooctanoic acid (PFOA) on gene expression profiles via nuclear receptors in HepaRG cells: Comparative study with in vitro transactivation assays.
  Wataru Murase; Atsuhito Kubota; Atsuko Ikeda-Araki; Masaru Terasaki; Koji Nakagawa; Ryota Shizu; Kouichi Yoshinari; Hiroyuki Kojima
  Toxicology, 494, 153577, 153577, 09 Jun. 2023, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Perfluorooctanoic acid (PFOA), a synthetic perfluorinated eight-carbon organic chemical, has been reported to induce hepatotoxicity, including increased liver weight, hepatocellular hypertrophy, necrosis, and increased peroxisome proliferation in rodents. Epidemiological studies have demonstrated associations between serum PFOA levels and various adverse effects. In this study, we investigated the gene expression profiles of human HepaRG cells exposed to 10 and 100 μM PFOA for 24h. Treatment with 10 and 100 μM PFOA significantly modulated the expression of 190 genes and 996 genes, respectively. In particular, genes upregulated or downregulated by 100µM PFOA included peroxisome proliferator-activated receptor (PPAR) signaling genes related to lipid metabolism, adipocyte differentiation, and gluconeogenesis. In addition, we identified the "Nuclear receptors-meta pathways" following the activation of other nuclear receptors: constitutive androstane receptor (CAR), pregnane X receptor (PXR) and farnesoid X receptor (FXR), and the transcription factor, nuclear factor E2-related factor 2 (Nrf2). The expression levels of some target genes (CYP4A11, CYP2B6, CYP3A4, CYP7A1, and GPX2) of these nuclear receptors and Nrf2 were confirmed using quantitative reverse transcription polymerase chain reaction. Next, we performed transactivation assays using COS-7 or HEK293 cells to investigate whether these signaling-pathways were activated by the direct effects of PFOA on human PPARα, CAR, PXR, FXR and Nrf2. PFOA activated PPARα in a concentration-dependent manner, but did not activate CAR, PXR, FXR, or Nrf2. Taken together, these results suggest that PFOA affects the hepatic transcriptomic responses of HepaRG cells through direct activation of PPARα and indirect activation of CAR, PXR FXR and Nrf2. Our finding indicates that PPARα activation found in the "Nuclear receptors-meta pathways" functions as a molecular initiating event for PFOA, and indirect activation of alternative nuclear receptors and Nrf2 also provide important molecular mechanisms in PFOA-induced human hepatotoxicity.
• PFOA曝露による肝細胞での遺伝子発現プロファイルと次世代への影響
  村瀬 渉; 窪田 篤人; 池田 敦子; 小島 弘幸
  環境化学物質3学会合同大会要旨集, 2回, 531, 532, (一社)日本環境化学会・日本環境毒性学会・環境ホルモン学会, May 2023
  Japanese
• Association between maternal multimorbidity and preterm birth, low birth weight and small for gestational age: a prospective birth cohort study from the Japan Environment and Children’s Study
  Kentaro Nakanishi; Yasuaki Saijo; Eiji Yoshioka; Yukihiro Sato; Yasuhito Kato; Ken Nagaya; Satoru Takahashi; Yoshiya Ito; Sumitaka Kobayashi; Chihiro Miyashita; Atsuko Ikeda-Araki; Reiko Kishi
  BMJ Open, 13, 3, e069281, e069281, BMJ, 15 Mar. 2023, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Objectives
  
  Multimorbidity is defined as the coexistence of two or more chronic physical or psychological conditions within an individual. The association between maternal multimorbidity and adverse perinatal outcomes such as preterm delivery and low birth weight has not been well studied. Therefore, this study aimed to investigate this association.
  
  Methods
  
  We conducted a prospective cohort study using data from the Japan Environment and Children’s Study of pregnant women between 2011 and 2014. Those with data on chronic maternal conditions were included in the study and categorised as having no chronic condition, one chronic condition or multimorbidities. The primary outcomes were the incidence of preterm birth (PTB), low birth weight (LBW) and small for gestational age (SGA). Adjusted logistic regression was performed to estimate ORs (aORs) and 95% CIs.
  
  Results
  
  Of the 104 062 fetal records, 86 885 singleton pregnant women were analysed. The median maternal age and body mass index were 31 years and 20.5 kg/m², respectively. The prevalence of pregnant women with one or more chronic conditions was 40.2%. The prevalence of maternal multimorbidity was 6.3%, and that of PTB, LBW, and SGA were 4.6%, 8.1%, and 7.5%, respectively. Pre-pregnancy underweight women were the most common, observed in 15.6% of multimorbidity cases, followed by domestic violence from intimate partner in 13.0%. Maternal multimorbidity was significantly associated with PTB (aOR 1.50; 95% CI 1.33–1.69), LBW (aOR 1.49; 95% CI 1.35–1.63) and SGA (aOR 1.33; 95% CI 1.20–1.46).
  
  Conclusion
  
  Maternal multimorbidity was associated with adverse perinatal outcomes, including PTB, LBW and SGA. The risk of adverse perinatal outcomes tends to increase with a rise in the number of chronic maternal conditions. Multimorbidity becomes more prevalent among pregnant women, making our findings important for preconception counselling.
• Environmental Research Addressing Sustainable Development Goals.
  James R Mihelcic; Ricardo O Barra; Bryan W Brooks; Miriam L Diamond; Matthew J Eckelman; Jacqueline MacDonald Gibson; Sunny Guidotti; Atsuko Ikeda-Araki; Manish Kumar; Ynoussa Maiga; Jennifer McConville; Shelly L Miller; Valeria Pizarro; Fernando Rosario-Ortiz; Shuxiao Wang; Julie B Zimmerman
  Environmental science & technology, 57, 9, 3457, 3460, 07 Mar. 2023, [International Magazine]
  English, Scientific journal
• 口唇口蓋裂を有した児の睡眠時間に関する研究 エコチル調査より
  佐藤 遊洋; 西條 泰明; 吉岡 英治; 加藤 育民; 長屋 建; 高橋 悟; 伊藤 善也; 小林 澄貴; アイツバマイ ゆふ; 山崎 圭子; 伊藤 佐智子; 宮下 ちひろ; 池田 敦子; 岸 玲子
  日本衛生学雑誌, 78, Suppl., S206, S206, (一社)日本衛生学会, Mar. 2023
  Japanese
• 子どものスクリーンタイムと聴覚・視覚ワーキングメモリーとの関連 北海道スタディ
  田村 菜穂美; 山崎 圭子; 宮下 ちひろ; 池田 敦子; 日景 隆; 水田 正弘; 大宮 学; 竹鼻 美月; 赤坂 梨莉花; 岸 玲子
  日本衛生学雑誌, 78, Suppl., S172, S172, (一社)日本衛生学会, Mar. 2023
  Japanese
• 学童期の子どもの電磁波曝露実態の変化 北海道スタディ
  山崎 圭子; 宮下 ちひろ; 田村 菜穂美; 池田 敦子; 日景 隆; 水田 正弘; 大宮 学; 岸 玲子
  日本衛生学雑誌, 78, Suppl., S215, S215, (一社)日本衛生学会, Mar. 2023
  Japanese
• 妊婦の母体血中水銀・セレン濃度と4歳までの児の神経発達との関連 エコチル調査
  小林 澄貴; 伊藤 佐智子; 宮下 ちひろ; アイツバマイ ゆふ; 山口 健史; 増田 秀幸; 伊藤 真利子; 山崎 圭子; 田村 菜穂美; ハンリー・シャロン; 池田 敦子; 西條 泰明; 伊藤 善也; 岸 玲子
  日本衛生学雑誌, 78, Suppl., S173, S173, (一社)日本衛生学会, Mar. 2023
  Japanese
• 前思春期のビスフェノール類曝露と性・ステロイドホルモン値との関連 北海道スタディ
  池田 敦子; 山口 健史; アイツバマイ ゆふ; 池中 良徳; ケテマ・ラヘルメスフィ; 曾 怡; 中村 明枝; 橘田 岳也; 今 雅史; 篠原 信雄; 真部 淳; 宮下 ちひろ; コバチ・アドリアン; 岸 玲子
  日本衛生学雑誌, 78, Suppl., S181, S181, (一社)日本衛生学会, Mar. 2023
  Japanese
• 化粧品使用による有機フッ素化合物の曝露推計
  藤谷 倫子; 原田 浩二; 増田 秀幸; 山口 健史; アイツバマイ ゆふ; 池田 敦子
  日本衛生学雑誌, 78, Suppl., S200, S200, (一社)日本衛生学会, Mar. 2023
  Japanese
• 化粧品使用による有機フッ素化合物の曝露推計
  藤谷 倫子; 原田 浩二; 増田 秀幸; 山口 健史; アイツバマイ ゆふ; 池田 敦子
  日本衛生学雑誌, 78, Suppl., S200, S200, (一社)日本衛生学会, Mar. 2023
  Japanese
• E-waste in Vietnam: a narrative review of environmental contaminants and potential health risks.
  Kritika Poudel; Rahel Mesfin Ketema; Hien Thi Thu Ngo; Atsuko Ikeda; Machiko Minatoya
  Reviews on environmental health, 09 Feb. 2023, [International Magazine]
  English, Scientific journal, Informal electronic waste (e-waste) dismantling activities contribute to releasing hazardous compounds in the environment and potential exposure to humans and their health. These hazardous compounds include persistent organic pollutants (POPs), polycyclic aromatic hydrocarbons (PAHs) and heavy metals. This review searched papers addressing hazardous compounds emitted from e-waste recycling activities and their health effects in Vietnam. Based on the keywords searched in three electronic databases (PubMed, Psych Info, and Google scholar), we found 21 relevant studies in Vietnam. The review identifies extensive e-waste dismantling activities in Vietnam in the northern region. To measure the environmental exposure to hazardous compounds, samples such as e-waste recycling workshop dust, soil, air, and sediments were assessed, while human exposure levels were measured using participants' hair, serum, or breast milk samples. Studies that compared levels of exposure in e-waste recycling sites and reference sites indicated higher levels of PBDEs, PCBs, and heavy metals were observed in both environmental and human samples from participants in e-waste recycling sites. Among environmental samples, hazardous chemicals were the most detected in dust from e-waste recycling sites. Considering both environmental and human samples, the highest exposure difference observed with PBDE ranged from 2-48-fold higher in e-waste processing sites than in the reference sites. PCBs showed nearly 3-fold higher levels in e-waste processing sites than in reference sites. In the e-waste processing sites, age-specific higher PCB levels were observed in older recycler's serum samples. Among the heavy metals, Pb was highly detected in drinking water, indoor soil and human blood samples. While high detection of Ni in cooked rice, Mn in soil and diet, Zn in dust and As in urine were apparent. Exposure assessment from human biomonitoring showed participants, including children and mothers from the e-waste processing areas, had higher carcinogenic and non-carcinogenic risks than the reference sites. This review paper highlights the importance of further comprehensive studies on risk assessments of environmentally hazardous substances and their association with health outcomes at e-waste processing sites.
• How does formal and informal industry contribute to lead exposure? A narrative review from Vietnam, Uruguay, and Malaysia.
  Kritika Poudel; Atsuko Ikeda; Hisanori Fukunaga; Marie-Noel Brune Drisse; Lesley Jayne Onyon; Julia Gorman; Amalia Laborde; Reiko Kishi
  Reviews on environmental health, 06 Feb. 2023, [Peer-reviewed], [Corresponding author], [International Magazine]
  English, Scientific journal, INTRODUCTION: Lead industries are one of the major sources of environmental pollution and can affect human through different activities, including industrial processes, metal plating, mining, battery recycling, etc. Although different studies have documented the various sources of lead exposure, studies highlighting different types of industries as sources of environmental contamination are limited. Therefore, this narrative review aims to focus mainly on lead industries as significant sources of environmental and human contamination. CONTENT: Based on the keywords searched in bibliographic databases we found 44 relevant articles that provided information on lead present in soil, water, and blood or all components among participants living near high-risk areas. We presented three case scenarios to highlight how lead industries have affected the health of citizens in Vietnam, Uruguay, and Malaysia. SUMMARY AND OUTLOOK: Factories conducting mining, e-waste processing, used lead-acid battery recycling, electronic repair, and toxic waste sites were the primary industries for lead exposure. Our study has shown lead exposure due to industrial activities in Vietnam, Uruguay, Malaysia and calls for attention to the gaps in strategic and epidemiologic efforts to understand sources of environmental exposure to lead fully. Developing strategies and guidelines to regulate industrial activities, finding alternatives to reduce lead toxicity and exposure, and empowering the public through various community awareness programs can play a crucial role in controlling exposure to lead.
• Change of radiofrequency electromagnetic exposure of children from 2020 to 2021: A report from Hokkaido Study
  Keiko Yamazaki; Naomi Tamura; Chihiro Miyashita; Toshio Yoshikawa; Atsuko Ikeda-Araki; Takashi Hikage; Manabu Omiya; Masahiro Mizuta; Miwa Ikuyo; Kazuhiro Tobita; Teruo Onishi; Masao Taki; Soichi Watanabe; Reiko Kishi
  2023 35th General Assembly and Scientific Symposium of the International Union of Radio Science, URSI GASS 2023, 2023
  International conference proceedings
• Human Body Blockage Effects on Personal Exposimeter Device in 4G/5G Frequency Bands for Epidemiological Research on Children's Health
  Sakura Tsuruga; Manabu Omiya; Chihiro Miyashita; Kaito Sugimura; Keiko Yamazaki; Naomi Tamura; Takashi Hikage; Atsuko Ikeda-Araki; Reiko Kishi
  2023 IEEE International Symposium on Antennas and Propagation, ISAP 2023, 2023
  International conference proceedings
• Cross-sectional associations between early mobile device usage and problematic behaviors among school-aged children in the Hokkaido Study on Environment and Children's Health.
  Chihiro Miyashita; Keiko Yamazaki; Naomi Tamura; Atsuko Ikeda-Araki; Satoshi Suyama; Takashi Hikage; Manabu Omiya; Masahiro Mizuta; Reiko Kishi
  Environmental health and preventive medicine, 28, 22, 22, 2023, [Peer-reviewed], [Domestic magazines]
  English, Scientific journal, BACKGROUND: Concerns have been raised about the adverse health impacts of mobile device usage. The objective of this cross-sectional study was to examine the association between a child's age at the first use of a mobile device and the duration of use as well as associated behavioral problems among school-aged children. METHODS: This study focused on children aged 7-17 years participating in the Hokkaido Study on Environment and Children's Health. Between October 2020 and October 2021, the participants (n = 3,021) completed a mobile device use-related questionnaire and the strengths and difficulties questionnaire (SDQ). According to the SDQ score (normal or borderline/high), the outcome variable was behavioral problems. The independent variable was child's age at first use of a mobile device and the duration of use. Covariates included the child's age at the time of survey, sex, sleep problems, internet addiction, health-related quality of life, and history of developmental concerns assessed at health checkups. Logistic regression analysis was performed for all children; the analysis was stratified based on the elementary, junior high, and senior high school levels. RESULTS: According to the SDQ, children who were younger at their first use of a mobile device and used a mobile device for a longer duration represented more problematic behaviors. This association was more pronounced among elementary school children. Moreover, subscale SDQ analysis showed that hyperactivity, and peer and emotional problems among elementary school children, emotional problems among junior high school children, and conduct problems among senior high school children were related to early and long usage of mobile devices. CONCLUSIONS: Elementary school children are more sensitive to mobile device usage than older children, and early use of mobile devices may exacerbate emotional instability and oppositional behaviors in teenagers. Longitudinal follow-up studies are needed to clarify whether these problems disappear with age.
• Associated congenital anomalies and syndromes of 248 infants with orofacial clefts born between 2011 and 2014 in the Japan environment and children's study.
  Yukihiro Sato; Eiji Yoshioka; Yasuaki Saijo; Yasuhito Kato; Ken Nagaya; Satoru Takahashi; Yoshiya Ito; Sumitaka Kobayashi; Yu Ait Bamai; Keiko Yamazaki; Sachiko Itoh; Chihiro Miyashita; Atsuko Ikeda-Araki; Reiko Kishi
  Congenital anomalies, 63, 1, 9, 15, Jan. 2023, [International Magazine]
  English, Scientific journal, This study aimed to document the complication status of infants with orofacial clefts born between 2011 and 2014 in Japan. This was a descriptive study using data from the Japan Environment and Children's Study. Among 103 060 pregnancies, 248 infants with orofacial clefts were included (livebirth, 239; stillbirth, 4; miscarriage, 5). The items of interest were complication status of orofacial clefts: isolated (typical orofacial clefts only); multi-malformed (orofacial clefts with unrelated major defects); syndromic (orofacial clefts with a syndrome or a chromosomal defect). Regarding the cleft subtypes, of 248 infants with orofacial clefts, 104 had cleft lip with cleft palate (CLP) (41.9%), 68 had cleft lip without cleft palate (CL) (27.4%), 58 had cleft palate without cleft lip (CP) (23.4%), and 18 were nonclassified (7.3%). In infants with CLP, the proportions of isolated, multi-malformed, and syndromic phenotypes were 73.1%, 15.4%, and 11.5%, respectively. In infants with CL, the proportions were 79.4%, 16.2%, and 4.4%, respectively. In infants with CP, the proportions were 69.0%, 13.8%, and 17.2%, respectively. The most frequently associated congenital anomaly was congenital heart disease. In infants with syndromic CLP, 41.7% had trisomy 13. In infants with syndromic CP, 80.0% had the Pierre Robin sequence. Congenital heart disease could be the most frequently associated congenital anomaly. The most frequently associated syndrome could be trisomy 13 in those with CLP and Pierre Robin sequence in those with CP.
• 胎児期フタル酸エステル類曝露による思春期発来への影響 北海道スタディ
  山口 健史; 池田 敦子; アイツバマイ ゆふ; 宮下 ちひろ; 池中 良徳; 中村 明枝; 今 雅史; 藤谷 倫子; 原田 浩二; 岸 玲子
  DOHaD研究, 10, 2, 46, 46, (一社)日本DOHaD学会, Oct. 2022
  Japanese
• 胎児期フタル酸エステル類曝露による思春期発来への影響 北海道スタディ
  山口 健史; 池田 敦子; アイツバマイ ゆふ; 宮下 ちひろ; 池中 良徳; 中村 明枝; 今 雅史; 藤谷 倫子; 原田 浩二; 岸 玲子
  DOHaD研究, 10, 2, 46, 46, (一社)日本DOHaD学会, Oct. 2022
  Japanese
• Measurement of personal radio frequency exposure in Japan: The Hokkaido Study on the Environment and Children's health.
  Keiko Yamazaki; Atsuko Ikeda-Araki; Chihiro Miyashita; Naomi Tamura; Toshio Yoshikawa; Takashi Hikage; Manabu Omiya; Masahiro Mizuta; Miwa Ikuyo; Kazuhiro Tobita; Teruo Onishi; Masao Taki; Soichi Watanabe; Reiko Kishi
  Environmental research, 216, Pt 1, 114429, 114429, 26 Sep. 2022, [International Magazine]
  English, Scientific journal, The opportunities for exposure to radiofrequency electromagnetic fields (RF-EMF) among children are increasing. Children's exposure to RF-EMF in Japan was recorded using a personal exposure meter (ExpoM-RF), and factors associated with the exposure examined. A total of 101 children, aged 10-15 years old, participated in the prospective birth cohort "Hokkaido study". RF-EMF data were recorded in the 700 MHz-5.8 GHz frequency range for 3 days. The recorded data were summarized into six groups of frequency bands: downlink from mobile phone base stations (DL), uplink from mobile phones to a base station (UL), Wireless Local Area Network (LAN), terrestrial digital TV broadcasting (digital TV), 2.5 GHz and 3.5 GHz Time Division Duplex (TDD), 1.9 GHz TDD, and total (the summation of power density in all measured frequency bands). A questionnaire was used to document the internet environment (at home) and mobile phone usage. Personal RF-EMF exposure in Japanese children was lower than that reported in studies in Europe. The DL signals from mobile phone base stations were the most significant contributors to total exposure, while Wireless LAN and digital TV were only higher at home. The urban residence was consistently associated with increases in the four groups of frequency bands (DL, UL, digital TV, and TDD). TDD level has several associations with mobile phone usage (calls using mobile phones, video viewing, text message service, and online game). The association between inattention/hyperactivity subscale of the Strengths and Difficulties Questionnaire (SDQ) and higher Wireless LAN exposure at nighttime was also noted. Further studies with additional data will shed light on factors involved in RF-EMF exposure among Japanese children.
• Null Association Between Isolated Orofacial Clefts and Sleep Duration: A Cohort Study From the Japan Environment and Children's Study
  Yukihiro Sato; Eiji Yoshioka; Yasuaki Saijo; Yasuhito Kato; Ken Nagaya; Satoru Takahashi; Yoshiya Ito; Sumitaka Kobayashi; Yu Ait Bamai; Keiko Yamazaki; Sachiko Itoh; Chihiro Miyashita; Atsuko Ikeda-Araki; Reiko Kishi
  The Cleft Palate-Craniofacial Journal, 105566562211284, 105566562211284, SAGE Publications, 26 Sep. 2022, [International Magazine]
  English, Scientific journal, Although children with orofacial clefts have an increased risk for sleep-disordered breathing, no studies have examined the association of sleep duration. Thus, this study aimed to examine associations between orofacial clefts and sleep duration at 1 month, 6 months, 1 year, and 3 years of age in Japan.
  
  A cohort study from the Japan Environment and Children's Study.
  
  This study consisted of 91 497 children, including ones with isolated cleft lip and palate (n = 69), isolated cleft lip only (n = 48), and isolated cleft palate only (n = 37), for which recruitment was undertaken during 2011 to 2014.
  
  Seep durations (hours per day) at 1 month, 6 months, 1 year, and 3 years of age, as reported by their mothers.
  
  In the control group, mean sleep durations and standard deviations at 1 month, 6 months, 1 year, and 3 years of age were 15.2 (2.5), 13.6 (1.9), 12.9 (1.6), and 11.6 (1.2) h, respectively. Compared to the control group, linear regression models reported effect sizes and 95% confidence intervals shorter than 1 h for sleep duration of each type of isolated orofacial cleft at each time point.
  
  This study suggested null associations between isolated orofacial clefts and sleep duration at 1 month, 6 months, 1 year, and 3 years of age. Children with isolated orofacial clefts had sufficient mean sleep duration.
• Evaluating association of smoking status during pregnancy with adverse birth outcomes using urinary cotinine concentration: The Japan environment and Children's study (JECS).
  Yuki Kunori; Yasuaki Saijo; Eiji Yoshioka; Yukihiro Sato; Tomoko Kanaya; Kentaro Nakanishi; Yasuhito Kato; Ken Nagaya; Satoru Takahashi; Yoshiya Ito; Sachiko Itoh; Sumitaka Kobayashi; Chihiro Miyashita; Atsuko Ikeda-Araki; Reiko Kishi; Michihiro Kamijima; Shin Yamazaki; Yukihiro Ohya; Reiko Kishi; Nobuo Yaegashi; Koichi Hashimoto; Chisato Mori; Shuichi Ito; Zentaro Yamagata; Hidekuni Inadera; Takeo Nakayama; Tomotaka Sobue; Masayuki Shima; Hiroshige Nakamura; Narufumi Suganuma; Koichi Kusuhara; Takahiko Katoh
  Environmental research, 215, Pt 2, 114302, 114302, 14 Sep. 2022, [International Magazine]
  English, Scientific journal, Urinary cotinine concentration (UCC) reflects smoking status. However, in pregnant women, its association with adverse birth outcomes related to fetal growth is not widely known. Thus, we aimed to explore this relationship by focusing on dose-response relationships. We investigated 86,638 pregnant women enrolled between 2011 and 2014 in a prospective cohort study in Japan and observed three birth outcomes (preterm birth, low birth weight, and small-for-gestational age). We measured UCC in the second or third trimester, and categorized the participants using cut-off values (negative cotinine concentration, passive cotinine concentration, and active cotinine concentration corresponding to non-smokers, passive smokers, and active smokers, respectively). Logistic regression analyses were conducted to evaluate the risks, and dose-response relationships were visualized using restricted cubic spline curves. Analyses based on self-reported smoking status were also performed. We found that in low active and highly active cotinine concentrations, the adjusted odds ratios (aORs) of birth outcomes were significantly increased (preterm birth, 1.24 [95% CI 1.06-1.46], 1.39 [95% CI 1.19-1.62]; low birth weight, 1.40 [95% CI 1.24-1.58], 2.27 [95% CI 2.05-2.53]; small-for-gestational age, 1.35 [95% CI 1.19-1.52], 2.39 [95% CI 2.16-2.65]). Restricted cubic spline curves demonstrated risk elevations in the active cotinine concentration range. Our research revealed dose-response relationships between UCC during pregnancy and the risks of preterm birth, low birth weight, and small-for-gestational age. Measurement of UCC to ascertain smoking status during pregnancy may be a useful approach for predicting the risks of these birth outcomes.
• Maternal dietary folate intake with folic acid supplements and wheeze and eczema in children aged 2 years in the Japan Environment and Children’s Study
  Hideyuki Masuda; Sumitaka Kobayashi; Chihiro Miyashita; Sachiko Itoh; Yu Ait Bamai; Yasuaki Saijo; Yoshiya Ito; Reiko Kishi; Atsuko Ikeda-Araki
  PLOS ONE, 17, 8, e0272968, e0272968, Public Library of Science (PLoS), 22 Aug. 2022, [International Magazine]
  English, Scientific journal, Maternal intake of folic acid supplements is reportedly associated with the risk of early-onset allergies in offspring. However, only a few studies have considered the intake of both folic acid supplements and dietary folate. Here, the relationship between maternal intake of folic acid supplements and allergic symptoms such as wheeze and eczema in offspring was analyzed while considering dietary folate intake. We examined 84,361 mothers and 85,114 children in the Japan Environment and Children’s Study. The participants were divided into three groups depending on maternal folic acid supplementation (“no use,” “occasional use,” and “daily use”). Each group was then subdivided into three groups based on total folic acid and dietary folate intake. Outcomes were determined considering the wheeze and eczema status of each child at the age of 2 years. The status was based on the International Study of Asthma and Allergies in Childhood. It was found that 22.1% of the mothers took folic acid supplements daily. In contrast, 56.3% of the mothers did not take these supplements. Maternal intake of folic acid supplements was not associated with wheeze and eczema in the offspring. In contrast, only dietary folate intake was positively associated with wheeze at the age of 2 (adjusted odds ratio, 1.103; 95% confidence interval, 1.003–1.212). However, there is no scientific evidence of a biological mechanism that clarifies this result. Potential confounders such as other nutrition, outdoor/indoor air pollution, and genetic factors may have affected the results. Therefore, further studies on the association between maternal intake of folic acid and allergic symptoms at the age of 3 or above are needed to confirm the results of this study.
  
  Trial registration
  
  UMIN Clinical Trials Registry (number: UMIN000030786)
• Potential determinants of T helper 2 markers and their distribution in school-aged children
  Houman Goudarzi; Atsuko Ikeda-Araki; Yu Ait Bamai; Sachiko Ito; Tasuku Inao; Isao Yokota; Chihiro Miyashita; Reiko Kishi; Satoshi Konno
  Allergology International, 72, 1, 100, 106, Elsevier BV, Aug. 2022, [International Magazine]
  English, Scientific journal, BACKGROUND: There is growing data on T helper 2 (Th2) biomarker determinants in adult populations. However, the determinants and typical range of these biomarkers have not been well studied in general populations of children. Therefore, we assessed the determinants and typical range of three Th2 biomarkers, including blood eosinophils, FeNO, and serum total IgE in 9-11-year-old children in a prospective birth cohort. METHODS: We examined the pre- and postnatal factors associated with Th2 biomarkers using multivariable logistic regression analysis (n = 428) and extended the results to the original cohort (n = 17,009) using inverse probability weighting. We also measured typical Th2 biomarker distribution in all examined children and healthy participants without allergic diseases (n = 180). RESULTS: At age 9-11, wheeze (odds ratio (OR) 7.63), rhinitis (OR 3.14), and eczema (OR 2.46) were significantly associated with increased blood eosinophils. All three allergic conditions were associated with FeNO and total serum IgE, but the ORs were smaller than those for blood eosinophils. Secondhand smoking was inversely associated with the blood eosinophils (OR, 0.38). Similar results were found in the original cohort. Male sex and prenatal factors (maternal smoking and parental history of allergies) were not independent predictors of high Th2 levels. CONCLUSIONS: In addition to wheezing and rhinitis, eczema and secondhand smoke exposure are independent factors for Th2 biomarker interpretation in children. Furthermore, the typical values and cutoff values of blood eosinophils in adults may not be applicable to children.
• Impact of prenatal exposure to mercury and selenium on neurodevelopmental delay in children in the Japan Environment and Children’s Study using the ASQ-3 questionnaire: a prospective birth cohort
  Sumitaka Kobayashi; Sachiko Itoh; Chihiro Miyashita; Yu Ait Bamai; Takeshi Yamaguchi; Hideyuki Masuda; Mariko Itoh; Keiko Yamazaki; Naomi Tamura; Sharon J.B. Hanley; Atsuko Ikeda-Araki; Yasuaki Saijo; Yoshiya Ito; Miyuki Iwai-Shimada; Shin Yamazaki; Michihiro Kamijima; Reiko Kishi
  Environment International, 168, 107448, 107448, Elsevier BV, Aug. 2022, [International Magazine]
  English, Scientific journal, Neurodevelopmental delay is associated with neurodevelopmental disorders. Prenatal metal exposure can potentially cause neurodevelopmental delays in children. This study examines whether prenatal exposure to mercury (Hg) and selenium (Se) is associated with the risk of neurodevelopmental delays in children up to 4 years of age. Children enrolled in a prospective birth cohort of the Japan Environment and Children's Study were examined. Hg and Se levels in maternal (nchild = 48,731) and cord (nchild = 3,083) blood were analyzed by inductively coupled plasma-mass spectrometry. Neurodevelopmental delays were assessed in children between the ages of 0.5 to 4 years using the Ages and Stages Questionnaires, Third Edition. The association between exposure and outcomes was examined using the generalized estimation equation models. In maternal blood, compared to participants with Se levels in the first quartile (83.0 to < 156 ng/g), the odds ratio (95 % confidence intervals) for problem-solving ability in children of mothers in the third (168 to < 181 ng/g) and fourth quartiles (181 to 976 ng/g) were 1.08 (1.01 to 1.14) and 1.10 (1.04 to 1.17), respectively. Furthermore, communication, gross and fine motor skills, and problem-solving delays were also observed. However, prenatal Hg levels in maternal and cord blood and Se levels in the latter were not associated with neurodevelopmental delays in children. Thus, the findings of this study suggest an association between Se levels in maternal blood and slightly increased risks of neurodevelopmental delays in children up to the age of 4 years.
• Narrative review of lead poisoning in humans caused by industrial activities and measures compatible with sustainable industrial activities in Republic of Zambia
  Hokuto Nakata; Shouta M.M. Nakayama; John Yabe; Kaampwe Muzandu; Andrew Kataba; Atsuko Ikeda-Araki; Marie-Noel Brune Drisse; Lesley Jayne Onyon; Julia Gorman; Poudel Kritika; Hisanori Fukunaga; Yoshinori Ikenaka; Reiko Kishi; Mayumi Ishizuka
  Science of The Total Environment, 850, 157833, 157833, Elsevier BV, Aug. 2022, [International Magazine]
  English, Scientific journal, Lead (Pb) pollution and human exposure to Pb, is an important issue for the international community to address being associated with 0.90 million deaths from long-term effects. The Republic of Zambia is a typical mineral resource-rich country, with long-standing mining and smelting activities of metals including Pb in several parts of the country. This narrative review provides a comprehensive overview of previous papers that have assessed human exposure to Pb and related health effects in Zambia. Environmental remediation methods that should be applied locally, ways to reduce Pb exposure of the population, and issues that need to be addressed by various sectors are discussed. Environmental remediation methods using locally available and affordable materials are needed to ensure both sustainable industrial activities and pollution prevention. In the Zambian mining towns, including Kabwe, various research activities have been conducted, including environmental monitoring, human biomonitoring and health impact assessments. The town of Kabwe, which was one of Zambia's largest Pb mining area in the 20th century, continues to have formal and informal Pb-related industries and is known as one of the most polluted areas in the world. For example, despite the World Health Organization asserting that "For an individual with a blood Pb concentration ≥ 5 μg/dL, appropriate action should be taken to terminate exposure", there are reports of blood Pb levels in Kabwe children exceeding 100 μg/dL. While Pb pollution is a global issue, not many places have such continuous and comprehensive research has been conducted, and there is much to be learned from the knowledge accumulated in these areas. Because the high levels of Pb accumulation in humans and the adverse health effects were clarified, we consider that it is important to combine mining activities, which are a key industry, with measures to prevent environmental pollution.
• Association between maternal caffeine intake during pregnancy and child development at 6 and 12 months: The Japan Environment and Children's Study
  Shinkichi Nishihara; Sumitaka Kobayashi; Atsuko Ikeda-Araki; Chihiro Miyashita; Sachiko Itoh; Keiko Yamazaki; Yu Ait Bamai; Naomi Tamura; Hideyuki Masuda; Mariko Itoh; Yasuaki Saijo; Yoshiya Ito; Reiko Kishi
  Early Human Development, 171, 105607, 105607, Elsevier BV, Jun. 2022, [International Magazine]
  English, Scientific journal, BACKGROUND: Caffeine intake by pregnant women may have neurodevelopmental effects on the fetus due to adenosine antagonism. However, there are insufficient data and inconsistent results from epidemiological studies on the effect of maternal caffeine intake on child development. AIMS: This study examined the association between mothers' estimated caffeine intake during pregnancy and their children's score on the Japanese version of the Ages & Stages Questionnaires™ (J-ASQ) at 6 and 12 months of age. STUDY DESIGN: The study is a part of nationwide prospective birth-cohort study: the Japan Environment and Children's Study. SUBJECTS: In total, 87,106 participants with the Food Frequency Questionnaire (FFQ) data and J-ASQ at 6 or 12 months of age were included in the study. OUTCOME MEASURES: The data were analyzed by logistic regression analysis to determine whether the scores of the five subscales on the J-ASQ were below the cutoff point as the dependent variable. RESULTS: The results showed that children born to mothers who consumed >300 mg caffeine per day had a 1.11-fold increased odds of gross motor developmental delay at 12 months of age (adjusted odds ratio [AOR] = 1.114 [95 % CI: 1.013-1.226]). CONCLUSIONS: Issues in gross motor development can emerge prior to future developmental issues. Therefore, further studies on developmental outcomes in older children, including the future outcomes of the children who participated in this study, are needed.
• The associations of prenatal exposure to dioxins and polychlorinated biphenyls with neurodevelopment at 6 Months of age: Multi-pollutant approaches.
  Gyeyoon Yim; Machiko Minatoya; Marianthi-Anna Kioumourtzoglou; Andrea Bellavia; Marc Weisskopf; Atsuko Ikeda-Araki; Chihiro Miyashita; Reiko Kishi
  Environmental research, 209, 112757, 112757, Jun. 2022, [Peer-reviewed], [International Magazine]
  English, Scientific journal, BACKGROUND: Prenatal exposure to persistent organic pollutants, including polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), dioxin-like polychlorinated biphenyls (DL-PCBs), and nondioxin-like PCBs (NDL-PCBs), has been hypothesized to have a detrimental impact on neurodevelopment. However, the association of prenatal exposure to a dioxin and PCB mixture with neurodevelopment remains largely inconclusive partly because these chemical levels are correlated. OBJECTIVES: We aimed to elucidate the association of in utero exposure to a mixture of dioxins and PCBs with neurodevelopment measured at 6 months of age by applying multipollutant methods. METHODS: A total of 514 pregnant women were recruited between July 2002 and October 2005 in the Sapporo cohort, Hokkaido Study on Environment and Children's Health. The concentrations of individual dioxin and PCB isomers were assessed in maternal peripheral blood during pregnancy. The mental and psychomotor development of the study participants' infants was evaluated using the Bayley Scales of Infant Development-2nd Edition (n = 259). To determine both the joint and individual associations of prenatal exposure to a dioxin and PCB mixture with infant neurodevelopment, Bayesian kernel machine regression (BKMR) and quantile-based g-computation were employed. RESULTS: Suggestive inverse associations were observed between in utero exposure to a dioxin and PCB mixture and infant psychomotor development in both the BKMR and quantile g-computation models. In contrast, we found no association of a dioxin and PCB mixture with mental development. When group-specific posterior inclusion probabilities were estimated, BKMR suggested prenatal exposure to mono-ortho PCBs as the more important contributing factors to early psychomotor development compared with the other dioxin or PCB groups. No evidence of nonlinear exposure-outcome relationships or interactions among the chemical mixtures was detected. CONCLUSIONS: Applying the two complementary statistical methods for chemical mixture analysis, we demonstrated limited evidence of inverse associations of prenatal exposure to dioxins and PCBs with infant psychomotor development.
• Association between pre-pregnancy body mass index and gestational weight gain and perinatal outcomes in pregnant women diagnosed with gestational diabetes mellitus: The Japan Environment and Children's Study.
  Yoshihiro Saito; Sumitaka Kobayashi; Atsuko Ikeda-Araki; Sachiko Ito; Chihiro Miyashita; Takashi Kimura; Takumi Hirata; Akiko Tamakoshi; Michinori Mayama; Kiwamu Noshiro; Kinuko Nakagawa; Takeshi Umazume; Kentaro Chiba; Satoshi Kawaguchi; Mamoru Morikawa; Kazutoshi Cho; Hidemichi Watari; Yoshiya Ito; Yasuaki Saijo; Reiko Kishi
  Journal of diabetes investigation, 13, 5, 889, 899, May 2022, [Peer-reviewed], [Domestic magazines]
  English, Scientific journal, AIMS/INTRODUCTION: We investigated the association between gestational diabetes mellitus (GDM) and perinatal outcomes stratified by pre-pregnancy body mass index (BMI) and/or gestational weight gain (GWG). MATERIALS AND METHODS: Data from the national birth cohort in the Japan Environment and Children's Study from 2011 to 2014 (n = 85,228) were used. Japan uses the GDM guidelines of the International Association of Diabetes and Pregnancy Study Groups. The odds ratios (ORs) of perinatal outcomes were compared between women with and those without GDM. RESULTS: The OR (95% confidence interval) of having a small for gestational age infant in the GDM group with a pre-pregnancy BMI of ≥25.0 kg/m2 and insufficient GWG (<2.75 kg) was 1.78 (1.02-3.12). The OR of having a large for gestational age infant of the same BMI group with excessive GWG (>7.25 kg) was 2.04 (1.56-2.67). The OR of hypertensive disorders of pregnancy was higher in women with a BMI ≥18.5 kg/m2 in the GDM group than in the non-GDM group. CONCLUSIONS: Large for gestational age and hypertensive disorders of pregnancy were associated with pre-pregnancy BMI and GWG in either normal weight or overweight/obese women, and the relationship was strengthened when GDM was present. Women with GDM and a BMI of ≥25.0 kg/m2 are at risk of having small for gestational age and large for gestational age infants depending on GWG.
• Effects of benzotriazole UV stabilizers, UV-PS and UV-P, on the differentiation of splenic regulatory T cells via aryl hydrocarbon receptor.
  Atsuhito Kubota; Masaru Terasaki; Yuuta Sakuragi; Ryuta Muromoto; Atsuko Ikeda-Araki; Hideshige Takada; Hiroyuki Kojima
  Ecotoxicology and environmental safety, 238, 113549, 113549, 29 Apr. 2022, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Benzotriazole UV stabilizers (BUVSs) are widely used as additives in various materials, including plastics, to prevent damage from UV-irradiation. However, despite the extensive usage of BUVSs, information on their toxicological properties is limited. In this study, we investigated the effect of BUVSs on the immune regulatory system via the aryl hydrocarbon receptor (AhR). A cell-based transactivation assay using DR-EcoScreen cells revealed that, among 13 BUVSs tested, UV-P, UV-PS, UV-9, and UV-090 activated AhR in a dose-dependent manner. In particular, the AhR agonistic activity of UV-PS was about 10-fold more potent than those of UV-P, UV-090, and UV-9, and UV-PS acted as a full agonist against AhR. In order to investigate the immune regulatory effects of these BUVSs, we orally treated C57BL/6 mice with UV-PS or UV-P (10, 30, and 100 mg/kg) and studied the differentiation of regulatory T cells (Tregs) in spleen cells. Flow-cytometry analysis revealed that the administration of UV-PS (30 and 100 mg/kg) or UV-P (100 mg/kg) significantly increased the population of CD4+-/CD25+-/Foxp3+ Tregs in the spleen. In addition, we found that the in vitro exposure of mouse splenocytes to UV-PS (10 and 30 μM) or UV-P (30 μM) as well as to TCDD (0.1 nM) significantly induced Tregs. Notably, the induction of Tregs was eliminated by co-treatment with an AhR antagonist, CH-223191, in each case. Taken together, these findings suggest that some BUVSs might induce Tregs through direct AhR activation and act as immunosuppressive modulators.
• Association of prenatal exposure to dioxin-like compounds, polychlorinated biphenyl, and methylmercury with event-related brain potentials in school-aged children: The Hokkaido study.
  Keiko Yamazaki; Sachiko Itoh; Atsuko Ikeda-Araki; Chihiro Miyashita; Tsuguhide Hori; Noriyuki Hachiya; Reiko Kishi
  Neurotoxicology, 91, 11, 21, 28 Apr. 2022, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Previous studies have indicated that prenatal exposure to dioxin-like compounds (DLC) or polychlorinated biphenyl (PCB) has a negative association with neurodevelopment in school-aged children. Event-related brain potentials (ERP) can reveal subtle and specific differences in the modulation of cognitive processes that are assumed when they are associated with lower levels of prenatal exposure to DLC or PCBs. This prospective birth cohort study was conducted to examine the association between prenatal exposure to relatively low levels of DLC, PCB or methylmercury (MeHg), and ERP. A total of 55 children who were 13 years old participated in a 3-stimulus oddball task to detect P3a and P3b waves. The task required participants to respond to a target among random stimuli at two difficulty levels. The P3a amplitude reflects an automated attention capture process, and P3b reflects a voluntary attention allocation process. We analyzed DLC congeners in blood samples from four groups, including 7 polychlorinated dibenzo-p-dioxins (PCDD), 10 polychlorinated dibenzofuranes (PCDF), 4 non-ortho PCBs, and 8 mono-ortho PCBs. PCB-153 was chosen as an indicator because of its high correlation with the sum of 58 NDL (non-dioxin-like)-PCBs. MeHg exposure level was assessed by the mercury concentration in hair samples (HHg) taken during the perinatal period. The reaction time to the target stimulus during the oddball task shortened with the increasing MeHg exposure level. Furthermore, P3b latency, which reflect response decision and correlates with reaction time, was also shortened with increasing MeHg level in the difficult condition. These results are counterintuitive because shorter reaction times or rapid decision making reflected by P3 latency are generally favorable. This might be due to nutritional factors such as fatty acids, which have beneficial effects on brain development. The P3a amplitude decreased with non- and mono-ortho PCB and HHg levels, regardless of the difficulty level, and with PCDD, PCDF, and total DLC levels, especially in the difficult condition. P3b latency shortened with HHg, and P3b amplitude decreased with mono-ortho PCBs and PCB-153 in both conditions and with PCDD, PCDF, non-ortho PCBs, and total DLC in the difficult condition. In conclusion, we found an association between prenatal exposure to DLC and a decrease in both P3a and P3b amplitude, even when DLC levels were lower than in most previous studies. Additionally, our results suggest that the automated attention capture process reflected by P3a is associated with maternal MeHg exposure and that the voluntary attention allocation process reflected by P3b is associated with PCB-153. However, these results should be interpreted with caution because of the limitations on sample size, population bias, and statistical analyses.
• Association of exposure to prenatal perfluoroalkyl substances and estrogen receptor 1 polymorphisms with the second to fourth digit ratio in school-aged children: The Hokkaido study.
  Yoko Nishimura; Kimihiko Moriya; Sumitaka Kobayashi; Atsuko Ikeda-Araki; Fumihiro Sata; Takahiko Mitsui; Sachiko Itoh; Chihiro Miyashita; Kazutoshi Cho; Masafumi Kon; Michiko Nakamura; Takeya Kitta; Sachiyo Murai; Reiko Kishi; Nobuo Shinohara
  Reproductive toxicology (Elmsford, N.Y.), 109, 10, 18, Apr. 2022, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Per- and Polyfluoroalkyl substances (PFAS) have endocrine-disrupting effects. The ratio of the lengths of the second and fourth digits (2D:4D) is a noninvasive retrospective index of prenatal exposure to sex hormones, and estrogen receptor 1 (ESR1) polymorphisms may contribute to 2D:4D determination. We investigated whether ESR1 polymorphisms modify the effects of prenatal PFAS exposure on 2D:4D. Participants (n = 1024) with complete data in a prospective birth cohort study (the Hokkaido Study) were included, and maternal plasma in the third trimester was used to examine PFAS concentrations. 2D:4D was determined from photocopies of palms of children using Vernier calipers. ESR1 polymorphisms (rs2234693, rs9340799, and rs2077647) were genotyped by TaqMan polymerase chain reaction. PFAS and 2D:4D association with ESR1 polymorphisms was assessed by multiple linear regression adjusted for potential confounding factors. A 10-fold increase in maternal perfluorooctanoic acid (PFOA) concentration was associated with a 1.54% [95% confidence interval (CI): 0.40, 2.68] increase in mean 2D:4D in children with an AA genotype at rs9340799 and a 2.24% (95% CI: 0.57, 3.92) increase in children with an AA genotype at rs2077647. A 10-fold increase in perfluorododecanoic acid (PFDoDA) was associated with a significant increase in 2D:4D in children with the AA genotype [rs9340799, 1.18% (95% CI: 0.02, 2.34); and rs2077647, 1.67% (95% CI: 0.05, 3.28)]. These associations were apparent among males. A significant gene-environment interaction between PFOA or PFDoDA and ESR1 polymorphism was detected. These findings suggest that ESR1 polymorphisms modify the effects of prenatal exposure to PFAS on sex differentiation.
• 学童のプラスチック添加剤への曝露実態 北海道スタディ
  池田 敦子; アイツバマイ ゆふ; Ketema Rahel Mesfin; Gys Celine; Bastiaensen Michiel; Covaci Adrian; 岸 玲子
  日本衛生学雑誌, 77, Suppl., S206, S206, (一社)日本衛生学会, Mar. 2022
  Japanese
• 小児の携帯情報端末の使用開始年齢と問題行動の程度との関連 北海道スタディ
  宮下 ちひろ; 山崎 圭子; 田村 菜穂美; 池田 敦子; 福永 久典; 日景 隆; 水田 正弘; 大宮 学; 岸 玲子
  日本衛生学雑誌, 77, Suppl., S189, S189, (一社)日本衛生学会, Mar. 2022
  Japanese
• 子どものスクリーンタイムおよび問題行動との関連 北海道スタディ
  田村 菜穂美; 山崎 圭子; 宮下 ちひろ; 池田 敦子; 福永 久典; 日景 隆; 水田 正弘; 大宮 学; 岸 玲子
  日本衛生学雑誌, 77, Suppl., S189, S189, (一社)日本衛生学会, Mar. 2022
  Japanese
• 学童期における携帯電話等の電磁波曝露の実態調査 北海道スタディ
  山崎 圭子; 田村 菜穂美; 宮下 ちひろ; 池田 敦子; 福永 久典; 日景 隆; 水田 正弘; 大宮 学; 岸 玲子
  日本衛生学雑誌, 77, Suppl., S199, S199, (一社)日本衛生学会, Mar. 2022
  Japanese
• Nonylphenol exposure in 7-year-old Japanese children between 2012 and 2017- Estimation of daily intakes based on novel urinary metabolites.
  Benedikt Ringbeck; Daniel Bury; Atsuko Ikeda-Araki; Yu Ait Bamai; Rahel Mesfin Ketema; Chihiro Miyashita; Thomas Brüning; Reiko Kishi; Holger M Koch
  Environment international, 161, 107145, 107145, Mar. 2022, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Nonylphenol (NP) has been under scrutiny for decades due to its endocrine-disrupting properties and its ubiquity in the environment. Despite its widespread occurrence, robust and reliable exposure data are rare. In this study, we used human biomonitoring (HBM) measuring the novel urinary alkyl-chain-oxidized biomarkers OH-NP and oxo-NP to determine NP exposure in 7-year-old Japanese children. The new biomarkers are advantageous over measuring unchanged NP because they are not prone to external contamination. We analyzed 180 first morning void urine samples collected between 2012 and 2017. OH-NP and oxo-NP were detected in 100% and 66% of samples at median concentrations of 2.69 and 0.36 µg/L, respectively. 10-fold concentration differences between OH-NP and oxo-NP are in line with recent findings on human NP metabolism. Based on OH-NP we back-calculated median and maximum NP daily intakes (DI) of 0.14 and 0.95 µg/(kg bw*d). These DIs are rather close to but still below the current provisional tolerable daily intake of 5 µg/(kg bw*d) by the Danish Environmental Protection Agency. Between 2012 and 2017 the DIs decreased by an average of 4.7% per year. We observed no seasonal changes or gender differences and questionnaire data on food consumption, housing characteristics or pesticide use showed no clear associations with NP exposure. Urinary OH-NP was weakly associated with the oxidative stress (lipid peroxidation) biomarkers N-ε-hexanoyl-lysine (HEL) and trans-4-hydroxy-2-nonenal (HNE) (Spearman ρ = 0.30 and 0.22, respectively), but not with 8-hydroxy-2'-deoxyguanosine (8-OHdG). Further research is needed to identify and understand the major sources of NP exposure and to investigate a potential role in oxidative stress. This study is the first to investigate NP exposure in Japanese children based on robust and sensitive HBM data. It is a first step to fill the long-standing gap in quantitative human NP exposure monitoring and risk assessment.
• Severity of low pre-pregnancy body mass index and perinatal outcomes: the Japan Environment and Children's Study.
  Kentaro Nakanishi; Yasuaki Saijo; Eiji Yoshioka; Yukihiro Sato; Yasuhito Kato; Ken Nagaya; Satoru Takahashi; Yoshiya Ito; Sumitaka Kobayashi; Chihiro Miyashita; Atsuko Ikeda-Araki; Reiko Kishi
  BMC pregnancy and childbirth, 22, 1, 121, 121, 11 Feb. 2022, [Peer-reviewed], [International Magazine]
  English, Scientific journal, BACKGROUND: The extremes of maternal pre-pregnancy body mass index (BMI) are known to be risk factors associated with obstetric and adverse perinatal outcomes. Among Japanese women aged 20 years or older, the prevalence of underweight (BMI < 18.5 kg/m2) was 11.5% in 2019. Maternal thinness is a health problem caused by the desire to become slim. This study aimed to investigate the association between the severity of maternal low pre-pregnancy BMI and adverse perinatal outcomes, including preterm birth (PTB), low birth weight (LBW), and small-for-gestational age (SGA). METHODS: We conducted a prospective cohort study using data from the Japan Environment and Children's Study, which recruited pregnant individuals between 2011 and 2014. Pre-pregnancy BMI was categorized as severe-moderate underweight (BMI < 16.9 kg/m2), mild underweight (BMI, 17.0-18.4 kg/m2), low-normal weight (BMI, 18.5-19.9 kg/m2), high-normal weight (BMI, 20.0-22.9 kg/m2), overweight (BMI, 23.0-24.9 kg/m2), and obese (BMI ≥ 25.0 kg/m2). The high-normal weight group was used as the reference for statistical analyses. Adjusted logistic regression was performed to evaluate the association between pre-pregnancy BMI and PTB, LBW, and SGA. RESULTS: Of 92,260 singleton pregnant individuals, the prevalence was 2.7% for severe-moderate underweight, 12.9% for mild underweight, and 24.5% for low-normal weight. The prevalence of adverse outcomes was 4.6% for PTB, 8.1% for LBW, and 7.6% for SGA. The adjusted odds ratios (aORs) for PTB were 1.72 (95% confidence interval [CI], 1.46-2.03) for severe-moderate underweight and 1.26 (95% CI, 1.14-1.39) for mild underweight. The aORs of LBW were 2.55 (95% CI, 2.27-2.86) for severe-moderate underweight, 1.64 (95% CI, 1.53-1.76) for mild underweight, and 1.23 (95% CI, 1.16-1.31) for low-normal weight. The aORs of SGA were 2.53 (95% CI, 2.25-2.84) for severe-moderate underweight, 1.66 (95% CI, 1.55-1.79) for mild underweight, and 1.29 (95% CI, 1.21-1.38) for low-normal weight. CONCLUSIONS: A dose-response relationship was found between the severity of low pre-pregnancy BMI and PTB, LBW, and SGA. Even low-normal BMI (18.5-19.9 kg/m2) increased the risk of LBW and SGA. This study provides useful information for pre-conception counseling in lean individuals.
• Phthalates mixture on allergies and oxidative stress biomarkers among children: The Hokkaido study.
  Rahel Mesfin Ketema; Yu Ait Bamai; Chihiro Miyashita; Takeshi Saito; Reiko Kishi; Atsuko Ikeda-Araki
  Environment international, 160, 107083, 107083, Feb. 2022, [Peer-reviewed], [Corresponding author], [International Magazine]
  English, Scientific journal, BACKGROUND: Exposure to individual phthalates and the mediation effect of oxidative stress in association with asthma and allergic symptoms have been studied previously. Little is known about the mixture effect of phthalates on health outcomes. Thus, we investigated the effect of a mixture of ten phthalate metabolites in association with wheeze, rhino-conjunctivitis, and eczema. The mediating effect of three oxidative stress biomarkers was also assessed. METHODS: Levels of 10 phthalate metabolites and 3 oxidative stress biomarkers were measured in 386 urine samples from 7-year-old children. Parents reported demographic and allergic symptoms using ISAAC questionnaires. Logistic regression for individual metabolites and mixture analysis weighted quantile sum (WQS) and Bayesian kernel machine regression (BKMR) were fitted to examine the association between phthalate metabolite exposure and health outcomes. Baron and Kenny's regression approach was used for mediation analysis. RESULTS: In logistic regression model showed mono (2-ethyl-5-carboxypentyl) phthalate (MECPP) (OR = 1.41, 95% CI 1.02-1.97) and mono carboxy-isononyl phthalate (cx-MINP) (OR = 1.40, 95% CI 1.07-1.86) were associated with wheeze. The WQS index had a significant association (OR = 1.46, 95% CI 1.09-1.96) with wheeze and (OR = 1.40, 95% CI 1.07-1.82) with eczema. Mono-isononyl phthalate (MINP) and mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP) were the most highly weighted metabolites. In the BKMR model, diisononyl phthalate (DINP) metabolites showed the highest group posterior inclusion probability (PIP). Among DINP metabolites, MINP in wheeze, cx-MINP in rhino-conjunctivitis and OH-MINP in eczema showed the highest conditional PIPs. The overall metabolites mixture effect was associated with eczema. We did not find any mediation of oxidative stress in the association between phthalates and symptoms. No significant association between phthalate metabolites and oxidative stress was observed in this study. CONCLUSION: Mixture of phthalate metabolites were associated with wheeze and eczema. The main contributors to the association were DEHP and DINP metabolites. No mediation of oxidative stress was observed.
• The association between prenatal perfluoroalkyl substance exposure and symptoms of attention-deficit/hyperactivity disorder in 8-year-old children and the mediating role of thyroid hormones in the Hokkaido study.
  Sachiko Itoh; Keiko Yamazaki; Satoshi Suyama; Atsuko Ikeda-Araki; Chihiro Miyashita; Yu Ait Bamai; Sumitaka Kobayashi; Hideyuki Masuda; Takeshi Yamaguchi; Houman Goudarzi; Emiko Okada; Ikuko Kashino; Takuya Saito; Reiko Kishi
  Environment international, 159, 107026, 107026, 15 Jan. 2022, [Peer-reviewed], [International Magazine]
  English, Scientific journal, BACKGROUND: Disruption of thyroid hormone (TH) levels during pregnancy contributes to attention deficit hyperactivity disorder (ADHD). Exposure to perfluoroalkyl substances (PFAS) during gestation may affect levels of maternal and neonatal TH; however, little is known about the effect of PFAS on ADHD mediated by TH. OBJECTIVES: We investigated the impact of maternal PFAS exposure on children's ADHD symptoms with the mediating effect of TH. METHODS: In a prospective birth cohort (the Hokkaido study), we included 770 mother-child pairs recruited between 2002 and 2005 for whom both prenatal maternal and cord blood samples were available. Eleven PFAS were measured in maternal serum obtained at 28-32 weeks of gestation using ultra-performance liquid chromatography coupled with triple quadrupole tandem mass spectrometry. TH and thyroid antibody, including thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), thyroid peroxidase antibody (TPOAb), and thyroglobulin antibody (TgAb) were measured in maternal blood during early pregnancy (median 11 gestational weeks) and in cord blood at birth. ADHD symptoms in the children at 8 years of age were rated by their parents using the ADHD-Rating Scale (ADHD-RS). The cut-off value was set at the 80th percentile for each sex. RESULTS: Significant inverse associations were found between some PFAS in maternal serum and ADHD symptoms among first-born children. Assuming causality, we found only one significant association: maternal FT4 mediated 17.6% of the estimated effect of perfluoroundecanoic acid exposure on hyperactivity-impulsivity among first-born children. DISCUSSION: Higher PFAS levels in maternal serum during pregnancy were associated with lower risks of ADHD symptoms at 8 years of age. The association was stronger among first-born children in relation to hyperactivity-impulsivity than with regard to inattention. There was little mediating role of TH during pregnancy in the association between maternal exposure to PFAS and reduced ADHD symptoms at 8 years of age.
• Effects of Persistent Organic Pollutants (POPs) in the Ecosystem and Human Health: Focusing on Chlorinated Chemicals
  Ikeda-Atsuko Araki; Chihiro Miyashita; Sumitaka Kobayashi; Keiko Yamazaki; Reiko Kishi
  The Handbook of Environmental Chemistry, 121, 143, Springer Nature Singapore, 01 Jan. 2022, [Peer-reviewed], [Invited], [Lead author]
  In book
• Environmental Impacts on Infectious Disease: A Literature View of Epidemiological Evidence.
  Peter D Sly; Brittany Trottier; Atsuko Ikeda-Araki; Dwan Vilcins
  Annals of global health, 88, 1, 91, 91, 2022, [International Magazine]
  English, Scientific journal, BACKGROUND: This article summarises a session from the recent Pacific Basin Consortium for Environment and Health Focus meeting on Environmental Impacts on Infectious Disease. OBJECTIVE: To provide an overview of the literature underpinning the presentations from this session. METHODS: References used in developing the presentations were obtained from the presenters. Additional references were obtained from PubMed using key words from the presentations. FINDINGS AND CONCLUSIONS: The Hokkaido longitudinal children's study has found that exposure to chemicals in early life, such as persistent organic pollutants and per/polyfluorinated compounds, is associated with a range of immunological outcomes such as decreased cord blood IgE, otitis media, wheeze, increased risk of infections and higher risk of food allergy.Epidemiological evidence links exposure to poor air quality to increased severity and mortality of Covid-19 in many parts of the world. Most studies suggest that long-term exposure has a more marked effect than acute exposure.Components of air pollution, such as a newly described combustion product known as environmentally persistent free radicals, induce oxidative stress in exposed individuals. Individuals with genetic variations predisposing them to oxidative stress are at increased risk of adverse health effects from poor air quality.
• Relations of mold, stove, and fragrance products on childhood wheezing and asthma: A prospective cohort study from the Japan Environment and Children's Study.
  Yasuaki Saijo; Eiji Yoshioka; Yukihiro Sato; Hiroshi Azuma; Yusuke Tanahashi; Yoshiya Ito; Sumitaka Kobayashi; Machiko Minatoya; Yu Ait Bamai; Keiko Yamazaki; Sachiko Itoh; Chihiro Miyashita; Atsuko Ikeda-Araki; Reiko Kishi; Michihiro Kamijima; Shin Yamazaki; Yukihiro Ohya; Nobuo Yaegashi; Koichi Hashimoto; Chisato Mori; Shuichi Ito; Zentaro Yamagata; Hidekuni Inadera; Takeo Nakayama; Hiroyasu Iso; Masayuki Shima; Youichi Kurozawa; Narufumi Suganuma; Koichi Kusuhara; Takahiko Katoh
  Indoor air, 32, 1, e12931, Jan. 2022, [Peer-reviewed], [International Magazine]
  English, Scientific journal, This prospective cohort study aimed to examine the associations between mold growth, type of stoves, and fragrance materials and early childhood wheezing and asthma, using data from the Japan Environment and Children's Study. Mold growth at home, usage of kerosene/gas stove, wood stove/fireplace, and air freshener/deodorizer were surveyed using a questionnaire at 1.5-year-old, and childhood wheezing and doctor-diagnosed asthma during the previous year were obtained using a 3-year-old questionnaire. Multilevel logistic regression analysis was performed to evaluate the association between exposure to childhood wheezing and asthma. A total of 60 529 children were included in the analysis. In multivariate analyses, mold growth and wood stove/fireplace had significantly higher odds ratios (ORs) for wheezing (mold growth: 1.13; 95% CI, 1.06-1.22; wood stove/fireplace: 1.23; 95% CI, 1.03-1.46). All four exposures had no significant ORs for childhood doctor-diagnosed asthma; however, in the supplemental analysis of northern regions, wood stove/fireplace had a significantly higher OR for asthma. Mold growth and wood stove/fireplace had significant associations with childhood wheezing in the northern regions. Mold elimination in the dwellings and use of clean heating (no air pollution emissions) should be taken into consideration to prevent and improve childhood wheezing and asthma.
• Associations between maternal mono-(2-ethylhexyl) phthalate levels, nuclear receptor gene polymorphisms, and fatty acid levels in pregnant Japanese women in the Hokkaido study.
  Sumitaka Kobayashi; Fumihiro Sata; Chihiro Miyashita; Atsuko Ikeda-Araki; Houman Goudarzi; Tamie Nakajima; Reiko Kishi
  Reproductive toxicology (Elmsford, N.Y.), 107, 22, 32, Jan. 2022, [Peer-reviewed], [International Magazine]
  English, Scientific journal, We assessed how the interaction between mono-(2-ethylhexyl) phthalate (MEHP) in maternal sera and the maternal genotypes associated with nuclear receptors affect fatty acid levels in a prospective birth cohort study of pregnant Japanese individuals (n = 437) recruited in Sapporo between 2002 and 2005. We analyzed MEHP and fatty acids using gas chromatography-mass spectrometry. Thirteen single nucleotide polymorphisms of peroxisome proliferator-activated receptor (PPAR) alpha, PPAR gamma (PPARG), PPARG coactivator 1A (PPARGC1A), PPAR delta, constitutive androstane receptor, liver X receptor (LXR) alpha, and LXR beta (LXRB) were analyzed using real-time PCR. Multiple linear regression models were used to confirm the influence of log10-transformed MEHP levels and maternal genotypes on log10-transformed fatty acid levels. When the effects of the interaction between MEHP levels and the maternal PPARGC1A (rs8192678) genotype on oleic acid levels were evaluated, the estimated changes (95 % confidence intervals) in oleic acid levels against MEHP levels, maternal PPARGC1A (rs8192678)-GA/AA genotype, and the interaction between them showed a mean reduction of 0.200 (0.079, 0.322), mean reduction of 0.141 (0.000, 0.283), and mean increase of 0.145 (0.010, 0.281), respectively, after adjusting for the perfluorooctanesulfonate level. The effects of the interaction between MEHP levels and maternal LXRB (rs2303044) genotype on linoleic acid levels was also significant (pint = 0.010). In conclusion, the interaction between MEHP and the maternal genotypes PPARGC1A (rs8192678) and LXRB (rs2303044) decreased fatty acid levels. Further, the interaction between MEHP and PPARGC1A (rs8192678) may have a greater effect on fatty acid levels than the interaction between PFOS and PPARGC1A.
• Relationships between maternal perfluoroalkyl substance levels, polymorphisms of receptor genes, and adverse birth outcomes in the Hokkaido birth cohort study, Japan.
  Sumitaka Kobayashi; Fumihiro Sata; Atsuko Ikeda-Araki; Chihiro Miyashita; Houman Goudarzi; Yusuke Iwasaki; Tamie Nakajima; Reiko Kishi
  Reproductive toxicology (Elmsford, N.Y.), 107, 112, 122, Jan. 2022, [Peer-reviewed], [International Magazine]
  English, Scientific journal, We assessed the associations between perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) levels in third trimester maternal serum, the maternal genotypes of genes encoding nuclear receptors, and birth outcomes. We studied a prospective birth cohort of healthy pregnant Japanese women (n = 372) recruited in Sapporo between July 2002 and October 2005. We analyzed PFOS and PFOA levels using liquid chromatography-tandem mass spectrometry and analyzed 13 single nucleotide polymorphisms (SNPs) of proliferator-activated receptor alpha, gamma, gamma coactivator 1A, delta, constitutive androstane receptor, liver X receptor alpha, and beta (LXRB) using real-time polymerase reaction (PCR). We employed multiple linear regression models to establish the influences of log10-transformed PFOS and PFOA levels and maternal genotypes on birth size. In female infants, we identified interactions between PFOS levels, the maternal genotype of LXRB (rs1405655), and birth weight. The estimated mean changes in birth weight in response to PFOS levels, the maternal genotype LXRB (rs1405655)-TC/CC (compared to TT), and their interactions were -502.9 g (95 % confidence interval [CI] = -247.3, -758.5 g), -526.3 g (95 % CI = -200.7, -852.0 g), and 662.1 g (95 % CI = 221.0, 1,103.2 g; pint = 0.003), respectively. Interactions between PFOS levels and the maternal genotype of LXRB (rs1405655) also significantly affected birth chest circumference and the Ponderal index (pint = 0.037 and 0.005, respectively). Thus, interactions between PFOS levels and the maternal genotype of LXRB (rs1405655) affects birth sizes in female infants. We found that certain SNPs modify the effects of PFOS levels on birth size.
• 一般家庭における短期/長期堆積ダストを活用したSVOCの曝露評価研究1 リン系難燃剤・可塑剤の室内濃度分布と汚染要因の解析
  戸次 加奈江; 池田 敦子; アイツバマイ ゆふ; 稲葉 洋平; 東 賢一; 金 勲; 岸 玲子
  室内環境学会学術大会講演要旨集, 2021年, 100, 101, (一社)室内環境学会, Dec. 2021
  Japanese
• 一般家庭における短期/長期堆積ダストを活用したSVOCの曝露評価研究2 子どものハウスダスト中リン系難燃剤・可塑剤の一日摂取量
  池田 敦子; 戸次 加奈江; アイツバマイ ゆふ; 稲葉 洋平; 金 勲; 岸 玲子
  室内環境学会学術大会講演要旨集, 2021年, 102, 103, (一社)室内環境学会, Dec. 2021
  Japanese
• Associations among perfluorooctanesulfonic/perfluorooctanoic acid levels, nuclear receptor gene polymorphisms, and lipid levels in pregnant women in the Hokkaido study
  Sumitaka Kobayashi; Fumihiro Sata; Houman Goudarzi; Atsuko Araki; Chihiro Miyashita; Seiko Sasaki; Emiko Okada; Yusuke Iwasaki; Tamie Nakajima; Reiko Kishi
  Scientific Reports, 11, 1, Springer Science and Business Media LLC, Dec. 2021, [Peer-reviewed]
  Scientific journal, The effect of interactions between perfluorooctanesulfonic (PFOS)/perfluorooctanoic acid (PFOA) levels and nuclear receptor genotypes on fatty acid (FA) levels, including those of triglycerides, is not clear understood. Therefore, in the present study, we aimed to analyse the association of PFOS/PFOA levels and single-nucleotide polymorphisms (SNPs) in nuclear receptors with FA levels in pregnant women. We analysed 504 mothers in a birth cohort between 2002 and 2005 in Japan. Serum PFOS/PFOA and FA levels were measured using liquid chromatography-tandem mass spectrometry and gas chromatography-mass spectrometry. Maternal genotypes in PPARA (rs1800234; rs135561), PPARG (rs3856806), PPARGC1A (rs2970847; rs8192678), PPARD (rs1053049; rs2267668), CAR (rs2307424; rs2501873), LXRA (rs2279238) and LXRB (rs1405655; rs2303044; rs4802703) were analysed. When gene-environment interaction was considered, PFOS exposure (log₁₀ scale) decreased palmitic, palmitoleic, and oleic acid levels (log₁₀ scale), with the observed β in the range of − 0.452 to − 0.244; PPARGC1A (rs8192678) and PPARD (rs1053049; rs2267668) genotypes decreased triglyceride, palmitic, palmitoleic, and oleic acid levels, with the observed β in the range of − 0.266 to − 0.176. Interactions between PFOS exposure and SNPs were significant for palmitic acid (P_int = 0.004 to 0.017). In conclusion, the interactions between maternal PFOS levels and PPARGC1A or PPARD may modify maternal FA levels.
• Hypertensive Disorders during Pregnancy and Anthropometric Measurement of Children up to 7 Years of Age: The Hokkaido Birth Cohort Study in Japan.
  Kritika Poudel; Sumitaka Kobayashi; Chihiro Miyashita; Takeshi Yamaguchi; Naomi Tamura; Atsuko Ikeda-Araki; Yu Ait Bamai; Sachiko Itoh; Keiko Yamazaki; Hideyuki Masuda; Mariko Itoh; Reiko Kishi
  International journal of environmental research and public health, 18, 20, 18 Oct. 2021, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Hypertensive disorders during pregnancy (HDP) increase the risk of offspring with a low birth weight, preterm birth and small-for-gestational age; however, evidence of the anthropometric measurements during early childhood remains limited. We aimed to understand the associations between maternal HDP and anthropometric measurements of children aged up to seven years in a Japanese cohort. In total, 20,926 mother-infant pairs participated in the Hokkaido Study on Environment and Children's Health, Japan, from 2002 to 2013. Medical reports were used to confirm HDP exposure, while weight, height, height z score, and weight z score were the outcomes. The prevalence of HDP in the study population was 1.7%. The birth height of male children born to HDP mothers was smaller as compared to those born to non-HDP mothers. When adjusted with covariates, the linear regressions showed significant changes in birth weight (β: -79.3; 95% confidence interval [CI]: -154.8, -3.8), birth height (-0.67; 95% CI: -1.07, -0.26), weight at seven years (1.21; 95% CI: 0.13, 2.29), and weight gain between four and seven years (1.12; 95% CI: 0.28, 1.96) of male children exposed to HDP. Differences were more significant in male children than female. Our study showed that despite low birth weight, male children exposed to HDP caught up with their growth and gained more weight by seven years of age compared with male children not exposed to HDP, whereas no such differences were observed in female children; however, this finding requires replication.
• Associations among maternal perfluoroalkyl substance levels, fetal sex-hormone enzymatic gene polymorphisms, and fetal sex hormone levels in the Hokkaido study
  Sumitaka Kobayashi; Fumihiro Sata; Atsuko Ikeda-Araki; Chihiro Miyashita; Sachiko Itoh; Houman Goudarzi; Yusuke Iwasaki; Takahiko Mitsui; Kimihiko Moriya; Nobuo Shinohara; Kazutoshi Cho; Reiko Kishi
  Reproductive Toxicology, 105, 221, 231, Elsevier BV, Oct. 2021, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Prenatal sex hormones affect fetal growth; for example, prenatal exposure to low levels of androgen accelerates female puberty onset. We assessed the association of perfluoroalkyl substances (PFASs) in maternal sera and infant genotypes of genes encoding enzymes involved in sex steroid hormone biosynthesis on cord sera sex hormone levels in a prospective birth cohort study of healthy pregnant Japanese women (n = 224) recruited in Sapporo between July 2002 and October 2005. We analyzed PFAS and five sex hormone levels using liquid chromatography-tandem mass spectrometry. Cytochrome P450 (CYP) 17A1 (CYP17A1 rs743572), 19A1 (CYP19A1 rs10046, rs700519, and rs727479), 3β-hydroxysteroid dehydrogenase type 1 (HSD3B1 rs6203), type 2 (HSD3B2 rs1819698, rs2854964, and rs4659175), 17β-hydroxysteroid dehydrogenase type 1 (HSD17B1 rs605059, rs676387, and rs2676531), and type 3 (HSD17B3 rs4743709) were analyzed using real-time PCR. Multiple linear regression models were used to establish the influence of log10-transformed PFAS levels and infant genotypes on log10-transformed sex steroid hormone levels. When the interaction between perfluorooctanesulfonate (PFOS) levels and female infant genotype CYP17A1 (rs743572) on the androstenedione (A-dione) levels was considered, the estimated changes (95 % confidence intervals) in A-dione levels against PFOS levels, female infant genotype CYP17A1 (rs743572)-AG/GG, and interaction between them showed a mean increase of 0.445 (0.102, 0.787), mean increase of 0.392 (0.084, 0.707), and mean reduction of 0.579 (0.161, 0.997) (Pint = 0.007), respectively. Moreover, a female-specific interaction with testosterone levels was observed. A-dione and T levels showed positive main effects and negative interaction with PFOS levels and the female infant CYP17A1 genotype.
• Association between the Concentrations of Metallic Elements in Maternal Blood during Pregnancy and Prevalence of Abdominal Congenital Malformations: The Japan Environment and Children’s Study
  Chihiro Miyashita; Yasuaki Saijo; Yoshiya Ito; Atsuko Ikeda-Araki; Sachiko Itoh; Keiko Yamazaki; Sumitaka Kobayashi; Yu Ait Bamai; Hideyuki Masuda; Naomi Tamura; Mariko Itoh; Takeshi Yamaguchi; Shin Yamazaki; Reiko Kishi
  International Journal of Environmental Research and Public Health, 18, 19, 10103, 10103, MDPI AG, 26 Sep. 2021, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Abdominal congenital malformations are responsible for early mortality, inadequate nutrient intake, and infant biological dysfunction. Exposure to metallic elements in utero is reported to be toxic and negatively impacts ontogeny. However, no prior study has sufficiently evaluated the effects of exposure to metallic elements in utero on abdominal congenital malformations. The aim of the present study was to evaluate associations between metallic elements detected in maternal blood during pregnancy and congenital abdominal malformations. Data from participants in the Japan Environment and Children’s Study was used in the present study, and contained information on singleton and live birth infants without congenital abnormalities (control: n = 89,134) and abdominal malformations (case: n = 139). Heavy metals such as mercury (Hg), lead (Pb), cadmium (Cd), and trace elements of manganese (Mn) and selenium (Se) were detected in maternal serum samples during mid- and late-gestation. Infant congenital abnormalities were identified from delivery records at birth or one month after birth by medical doctors. In a multivariate analysis adjusted to account for potential confounders, quartiles of heavy metals and trace elements present in maternal blood were not statistically correlated to the prevalence of abdominal congenital malformations at birth. This study is the first to reveal the absence of significant associations between exposure levels to maternal heavy metals and trace elements in utero and the prevalence of abdominal congenital malformations in a large cohort of the Japanese population. Further studies are necessary to investigate the impact of exposure to heavy metals and trace elements via maternal blood in offspring after birth.
• DNA methylation changes associated with prenatal mercury exposure: A meta-analysis of prospective cohort studies from PACE consortium.
  Manuel Lozano; Paul Yousefi; Karin Broberg; Raquel Soler-Blasco; Chihiro Miyashita; Giancarlo Pesce; Woo Jin Kim; Mohammad Rahman; Kelly M Bakulski; Line S Haug; Atsuko Ikeda-Araki; Guy Huel; Jaehyun Park; Caroline Relton; Martine Vrijheid; Sheryl Rifas-Shiman; Emily Oken; John F Dou; Reiko Kishi; Kristine B Gutzkow; Isabella Annesi-Maesano; Sungho Won; Marie-France Hivert; M Daniele Fallin; Marina Vafeiadi; Ferran Ballester; Mariona Bustamante; Sabrina Llop
  Environmental research, 204, Pt B, 112093, 112093, 22 Sep. 2021, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal, Mercury (Hg) is a ubiquitous heavy metal that originates from both natural and anthropogenic sources and is transformed in the environment to its most toxicant form, methylmercury (MeHg). Recent studies suggest that MeHg exposure can alter epigenetic modifications during embryogenesis. In this study, we examined associations between prenatal MeHg exposure and levels of cord blood DNA methylation (DNAm) by meta-analysis in up to seven independent studies (n = 1462) as well as persistence of those relationships in blood from 7 to 8 year-old children (n = 794). In cord blood, we found limited evidence of differential DNAm at cg24184221 in MED31 (β = 2.28 × 10-4, p-value = 5.87 × 10-5) in relation to prenatal MeHg exposure. In child blood, we identified differential DNAm at cg15288800 (β = 0.004, p-value = 4.97 × 10-5), also located in MED31. This repeated link to MED31, a gene involved in lipid metabolism and RNA Polymerase II transcription function, may suggest a DNAm perturbation related to MeHg exposure that persists into early childhood. Further, we found evidence for association between prenatal MeHg exposure and child blood DNAm levels at two additional CpGs: cg12204245 (β = 0.002, p-value = 4.81 × 10-7) in GRK1 and cg02212000 (β = -0.001, p-value = 8.13 × 10-7) in GGH. Prenatal MeHg exposure was associated with DNAm modifications that may influence health outcomes, such as cognitive or anthropometric development, in different populations.
• The protocol for the study about association between radio frequency wave and children's health: The Hokkaido study on environment and children's health
  Keiko Yamazaki; Atsuko Araki; Chihiro Miyashita; Naomi Tamura; Takashi Hikage; Manabu Omiya; Masahiro Mizuta; Reiko Kishi
  2021 34th General Assembly and Scientific Symposium of the International Union of Radio Science, URSI GASS 2021, 28 Aug. 2021
  International conference proceedings
• Effect of prenatal exposure to phthalates on epigenome-wide DNA methylations in cord blood and implications for fetal growth: The Hokkaido Study on Environment and Children's Health.
  Ryu Miura; Atsuko Ikeda-Araki; Toru Ishihara; Kunio Miyake; Chihiro Miyashita; Tamie Nakajima; Sumitaka Kobayashi; Mayumi Ishizuka; Takeo Kubota; Reiko Kishi
  The Science of the total environment, 783, 147035, 147035, 20 Aug. 2021, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Prenatal exposure to phthalates negatively affects the offspring's health. In particular, epigenetic alterations, such as DNA methylation, may connect phthalate exposure with health outcomes. Here, we evaluated the association of di-2-ethylhexyl phthalate (DEHP) exposure in utero with cord blood epigenome-wide DNA methylation in 203 mother-child pairs enrolled in the Hokkaido Study on Environment and Children's Health, using the Illumina HumanMethylation450 BeadChip. Epigenome-wide association analysis demonstrated the predominant positive associations between the levels of the primary metabolite of DEHP, mono(2-ethylhexyl) phthalate (MEHP), in maternal blood and DNA methylation levels in cord blood. The genes annotated to the CpGs positively associated with MEHP levels were enriched for pathways related to metabolism, the endocrine system, and signal transduction. Among them, methylation levels of CpGs involved in metabolism were inversely associated with the offspring's ponderal index (PI). Further, clustering and mediation analyses suggested that multiple increased methylation changes may jointly mediate the association of DEHP exposure in utero with the offspring's PI at birth. Although further studies are required to assess the impact of these changes, this study suggests that differential DNA methylation may link phthalate exposure in utero to fetal growth and further imply that DNA methylation has predictive value for the offspring's obesity.
• Maternal psychological distress, education, household income, and congenital heart defects: a prospective cohort study from the Japan environment and children's study.
  Yasuaki Saijo; Eiji Yoshioka; Yukihiro Sato; Hiroshi Azuma; Yusuke Tanahashi; Yoshiya Ito; Sumitaka Kobayashi; Machiko Minatoya; Yu Ait Bamai; Keiko Yamazaki; Sachiko Itoh; Chihiro Miyashita; Atsuko Ikeda-Araki; Reiko Kishi
  BMC pregnancy and childbirth, 21, 1, 544, 544, 07 Aug. 2021, [Peer-reviewed], [International Magazine]
  English, Scientific journal, BACKGROUND: The influence of maternal psychological distress on infant congenital heart defects (CHDs) has not been thoroughly investigated. Furthermore, there have been no reports on the combined effect of maternal psychological distress and socioeconomic status on infant CHDs. This study aimed to examine whether maternal psychological distress, socioeconomic status, and their combinations were associated with CHD. METHODS: We conducted a prospective cohort study using data from the Japan Environment and Children's Study, which recruited pregnant women between 2011 and 2014. Maternal psychological distress was evaluated using the Kessler Psychological Distress Scale in the first trimester, while maternal education and household income were evaluated in the second and third trimesters. The outcome of infant CHD was determined using the medical records at 1 month of age and/or at birth. Crude- and confounder-adjusted logistic regression analyses were performed to evaluate the association between maternal psychological distress and education and household income on infant CHD. RESULTS: A total of 93,643 pairs of mothers and infants were analyzed, with 1.1% of infants having CHDs. Maternal psychological distress had a significantly higher odds ratio in the crude analysis but not in the adjusted analysis, while maternal education and household income were statistically insignificant. In the analysis of the combination variable of lowest education and psychological distress, the P for trend was statistically significant in the crude and multivariate model excluding anti-depressant medication, but the significance disappeared in the full model (P = 0.050). CONCLUSIONS: The combination of maternal psychological distress and lower education may be a possible indicator of infant CHD.
• An analytical survey of benzotriazole UV stabilizers in plastic products and their endocrine-disrupting potential via human estrogen and androgen receptors.
  Yuuta Sakuragi; Hideshige Takada; Hiroya Sato; Atsuhito Kubota; Masaru Terasaki; Shinji Takeuchi; Atsuko Ikeda-Araki; Yoko Watanabe; Shigeyuki Kitamura; Hiroyuki Kojima
  The Science of the total environment, 800, 149374, 149374, 31 Jul. 2021, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Benzotriazole UV stabilizers (BUVSs) are added to various materials to prevent damage from UV-irradiation. Recently, there has been great concern regarding the endocrine-disrupting effects of exposure to microplastic-derivative BUVSs in particular. In this study, we measured the concentrations of nine representative BUVSs in the plastic bottle caps of 10 beverages, 4 food packages, and 4 plastic shopping bags purchased from Japanese grocery stores by GC-MS analysis, and found that eight BUVSs, except for 2-(3,5-di-tert-butyl-2-hydroxyphenyl)-2H-benzotriazole (UV-320), were detected from these plastic products. In particular, 2-(2-hydroxy-5-methylphenyl) benzotriazole (UV-P) and 2-(2-hydroxy-3-tert-butyl-5-methylphenyl)-5-chlorobenzotriazole (UV-326) were detected from all the bottle caps at concentrations in the order of ng/g. In addition, we characterized the agonistic and/or antagonistic activities against human estrogen receptors (ERα/β) and androgen receptor (AR) of 13 BUVSs. Results revealed that, among the 13 BUVSs, UV-P, 2-(5-tert-butyl-2-hydroxyphenyl) benzotriazole (UV-PS), 2-[2-hydroxy-5-[2-(methacryloyloxy)ethyl]phenyl]-2H-benzotriazole (UV-090) and 2-(2-hydroxy-5-tert-octylphenyl)-benzotriazole (UV-329) showed ERα and/or ERβ agonistic activity, with UV-P being the most potent based on these assays. On the other hand, UV-320 and 2-(3-s-butyl-5-tert-butyl-2-hydroxyphenyl) benzotriazole (UV-350) showed both ERα and ERβ antagonistic activities, and 2-(3,5-di-tert-amyl-2-hydroxylphenyl) benzotriazole (UV-328) and UV-329 acted as ERβ antagonists. In the AR assay, UV-P and 2-(3-allyl-2-hydroxy-5-methylphenyl)-2H-benzotriazole (UV-9) showed AR antagonistic activity although none of the test compounds showed AR agonistic activity. Taken together, our findings suggest that a series of BUVSs are present in our environments via plastic materials and several of these compounds possess endocrine-disrupting potential, such as ERα/β agonistic and/or antagonistic activity and AR antagonistic activity. UV-P and its structurally similar compounds, in particular, appear to be a cause for concern.
• Association between Early Life Child Development and Family Dog Ownership: A Prospective Birth Cohort Study of the Japan Environment and Children's Study.
  Machiko Minatoya; Atsuko Ikeda-Araki; Chihiro Miyashita; Sachiko Itoh; Sumitaka Kobayashi; Keiko Yamazaki; Yu Ait Bamai; Yasuaki Saijo; Yukihiro Sato; Yoshiya Ito; Reiko Kishi; The Japan Environment And Children's Study Group
  International journal of environmental research and public health, 18, 13, 02 Jul. 2021, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Pets may play a role in the social-emotional development of children. In particular, some studies have suggested that family dog ownership is associated with better health outcomes. To date, no study has assessed child development in association with dog ownership of different time points. The purpose of the current study was primary to investigate whether "ever" family dog ownership was associated with early child development, and secondary to further examine whether associations between family dog ownership and early child development differ among family dog ownership of status, including "past only", "current only", and "always" groups, using the data of family dog ownership obtained at multiple time points. Associations between family dog ownership and infant development at 3 years of age were examined using data from a nationwide prospective birth cohort study, the Japan Environment and Children's Study (n = 78,941). "Ever" family dog ownership was categorized to "past only", "current only", and "always". We observed that children with "ever" family dog ownership showed a significantly decreased risk of developmental delay in the communication (odds ratio [OR] = 0.87; 95% confidence interval [CI]: 0.78, 0.96), gross motor (OR = 0.83; 95% CI: 0.76, 0.92), problem-solving (OR = 0.89; 95% CI: 0.83, 0.96) and personal-social (OR = 0.86; 95% CI: 0.72, 0.92) domains compared to children with "never" family dog ownership. Furthermore, a significantly decreased risk of developmental delay in gross motor function was observed in association with living with dogs in the "past only" (OR = 0.83; 95% CI: 0.73, 0.95) and "always" (OR = 0.86; 95% CI: 0.75, 0.98). In addition, a decreased risk of developmental delay in the problem-solving domain was associated with "past" family dog ownership (OR = 0.87; 95% CI: 0.79, 0.97) and in the personal-social domain was associated with "always" family dog ownership (OR = 0.81; 95% CI = 0.68, 0.95). Given the possible positive association between early life child development and family dog ownership, living with dogs may be an important factor to be considered when assessing child development.
• Prenatal alcohol exposure and adverse fetal growth restriction: findings from the Japan Environment and Children's Study.
  Kazutoshi Cho; Sumitaka Kobayashi; Atsuko Araki; Chihiro Miyashita; Sachiko Itoh; Yasuaki Saijo; Yoshiya Ito; Kazuo Sengoku; Tsuyoshi Baba; Hisanori Minakami; Yuichi Nakamura; Reiko Kishi
  Pediatric research, 92, 1, 291, 298, 04 Jun. 2021, [International Magazine]
  English, Scientific journal, BACKGROUNDS: Japanese studies on the association between maternal alcohol consumption and fetal growth are few. This study assessed the effect of maternal alcohol consumption on fetal growth. METHODS: This prospective birth cohort included 95,761 participants enrolled between January 2011 and March 2014 in the Japan Environment and Children's Study. Adjusted multiple linear and logistic regression models were used to assess the association between prenatal alcohol consumption and infant birth size. RESULTS: Consumption of a weekly dose of alcohol in the second/third trimester showed a significant negative correlation with standard deviation (SD; Z) scores for body weight, body length, and head circumference at birth, respectively. Consumption of a weekly dose of alcohol during the second/third trimester had a significant positive correlation with incidences of Z-score ≤ -1.5 for birth head circumference. Associations between alcohol consumption in the second/third trimester and Z-score ≤ -1.5 for birth weight or birth length were not significant. Maternal alcohol consumption in the second/third trimester above 5, 20, and 100 g/week affected body weight, body length, and head circumference at birth, respectively. CONCLUSION: Low-to-moderate alcohol consumption during pregnancy might affect fetal growth. Public health policies for pregnant women are needed to stop alcohol consumption during pregnancy. IMPACT: This study examined the association between maternal alcohol consumption and fetal growth restriction in 95,761 pregnant Japanese women using the prospective birth cohort. Maternal alcohol consumption in the second/third trimester more than 5, 20, and 100 g/week might affect fetal growth in body weight, body length, and head circumference, respectively. The findings are relevant and important for educating pregnant women on the adverse health effects that prenatal alcohol consumptions have on infants.
• Hokkaido birth cohort study on environment and children's health: cohort profile 2021.
  Reiko Kishi; Atsuko Ikeda-Araki; Chihiro Miyashita; Sachiko Itoh; Sumitaka Kobayashi; Yu Ait Bamai; Keiko Yamazaki; Naomi Tamura; Machiko Minatoya; Rahel Mesfin Ketema; Kritika Poudel; Ryu Miura; Hideyuki Masuda; Mariko Itoh; Takeshi Yamaguchi; Hisanori Fukunaga; Kumiko Ito; Houman Goudarzi
  Environmental health and preventive medicine, 26, 1, 59, 59, 22 May 2021, [Peer-reviewed], [International Magazine]
  English, Scientific journal, BACKGROUND: The Hokkaido Study on Environment and Children's Health is an ongoing study consisting of two birth cohorts of different population sizes: the Sapporo cohort and the Hokkaido cohort. Our primary objectives are to (1) examine the effects that low-level environmental chemical exposures have on birth outcomes, including birth defects and growth retardation; (2) follow the development of allergies, infectious diseases, and neurobehavioral developmental disorders, as well as perform a longitudinal observation of child development; (3) identify high-risk groups based on genetic susceptibility to environmental chemicals; and (4) identify the additive effects of various chemicals, including tobacco. METHODS: The purpose of this report is to provide an update on the progress of the Hokkaido Study, summarize recent results, and suggest future directions. In particular, this report provides the latest details from questionnaire surveys, face-to-face examinations, and a collection of biological specimens from children and measurements of their chemical exposures. RESULTS: The latest findings indicate different risk factors of parental characteristics on birth outcomes and the mediating effect between socioeconomic status and children that are small for the gestational age. Maternal serum folate was not associated with birth defects. Prenatal chemical exposure and smoking were associated with birth size and growth, as well as cord blood biomarkers, such as adiponectin, leptin, thyroid, and reproductive hormones. We also found significant associations between the chemical levels and neuro development, asthma, and allergies. CONCLUSIONS: Chemical exposure to children can occur both before and after birth. Longer follow-up for children is crucial in birth cohort studies to reinforce the Developmental Origins of Health and Disease hypothesis. In contrast, considering shifts in the exposure levels due to regulation is also essential, which may also change the association to health outcomes. This study found that individual susceptibility to adverse health effects depends on the genotype. Epigenome modification of DNA methylation was also discovered, indicating the necessity of examining molecular biology perspectives. International collaborations can add a new dimension to the current knowledge and provide novel discoveries in the future.
• Parental educational level and childhood wheezing and asthma: A prospective cohort study from the Japan Environment and Children’s Study
  Yasuaki Saijo; Eiji Yoshioka; Yukihiro Sato; Toshinobu Miyamoto; Hiroshi Azuma; Yusuke Tanahashi; Yoshiya Ito; Sumitaka Kobayashi; Machiko Minatoya; Yu Ait Bamai; Keiko Yamazaki; Sachiko Itoh; Chihiro Miyashita; Atsuko Araki; Reiko Kishi
  PLOS ONE, 16, 4, e0250255, e0250255, Public Library of Science (PLoS), 16 Apr. 2021
  Scientific journal,
  
  The influence of mothers’ and fathers’ educational levels in separate evaluations of asthma has not been fully investigated. This study aims to examine the associations of the mother’s and fathers’ educational levels with childhood wheeze and asthma adjusting for crude and pre-and post-natal modifiable risk factors.
  
  
  
  
  
  We conducted a prospective cohort study using data from the Japan Environment and Children’s Study, which recruited pregnant women from 2011 to 2014. The mother’s and father’s educational levels were surveyed by a questionnaire during the pregnancy, and childhood wheezing and doctor-diagnosed asthma were estimated using a 3-year questionnaire. Multilevel logistic regression analysis was performed to evaluate the association between the mother’s and father’s educational levels and childhood wheezing and asthma, adjusted for pre-and post-natal factors.
  
  
  
  
  
  A total of 69,607 pairs of parents and their single infants were analyzed. We found 17.3% of children had wheezing and 7.7% had asthma. In crude analyses, lower educational level of parents was associated with an increased risk of childhood wheezing and asthma. After full adjustment, a lower educational level of mothers was associated with an increased risk of childhood asthma (junior high school (reference: high school); odds ratio (OR): 1.17, 95% CI, 1.01–1.36), and higher educational level, especially the mother’s, was associated with an increased risk of childhood wheezing (technical junior college, technical/vocational college, or associate degree (ECD3); OR: 1.12, 95% CI, 1.06–1.18, bachelor’s degree, or postgraduate degree; OR: 1.10, 95% CI, 1.03–1.18), and asthma (ECD3; OR: 1.13, 95% CI, 1.04–1.21).
  
  
  
  
  
  Parents’ lower educational level was a crude risk factor for childhood wheezing and asthma. However, an increased risk of wheezing due to mothers’ higher educational level was found after adjusting for pre-and post-natal factors.
  
  
  
• DNA methylation of GFI1 as a mediator of the association between prenatal smoking exposure and ADHD symptoms at 6 years: the Hokkaido Study on Environment and Children's Health.
  Kunio Miyake; Chihiro Miyashita; Atsuko Ikeda-Araki; Ryu Miura; Sachiko Itoh; Keiko Yamazaki; Sumitaka Kobayashi; Hideyuki Masuda; Tadao Ooka; Zentaro Yamagata; Reiko Kishi
  Clinical epigenetics, 13, 1, 74, 74, 07 Apr. 2021, [Peer-reviewed], [International Magazine]
  English, Scientific journal, BACKGROUND: Prenatal smoking exposure has been associated with childhood attention-deficit/hyperactivity disorder (ADHD). However, the mechanism underlying this relationship remains unclear. We assessed whether DNA methylation differences may mediate the association between prenatal smoking exposure and ADHD symptoms at the age of 6 years. RESULTS: We selected 1150 mother-infant pairs from the Hokkaido Study on the Environment and Children's Health. Mothers were categorized into three groups according to plasma cotinine levels at the third trimester: non-smokers (≤ 0.21 ng/mL), passive smokers (0.21-11.48 ng/mL), and active smokers (≥ 11.49 ng/mL). The children's ADHD symptoms were determined by the ADHD-Rating Scale at the age of 6 years. Maternal active smoking during pregnancy was significantly associated with an increased risk of ADHD symptoms (odds ratio, 1.89; 95% confidence interval, 1.14-3.15) compared to non-smoking after adjusting for covariates. DNA methylation of the growth factor-independent 1 transcriptional repressor (GFI1) region, as determined by bisulfite next-generation sequencing of cord blood samples, mediated 48.4% of the total effect of the association between maternal active smoking during pregnancy and ADHD symptoms. DNA methylation patterns of other genes (aryl-hydrocarbon receptor repressor [AHRR], cytochrome P450 family 1 subfamily A member 1 [CYP1A1], estrogen receptor 1 [ESR1], and myosin IG [MYO1G]) regions did not exert a statistically significant mediation effect. CONCLUSIONS: Our findings demonstrated that DNA methylation of GFI1 mediated the association between maternal active smoking during pregnancy and ADHD symptoms at the age of 6 years.
• Prevalence of childhood wheeze and modified DNA methylation at 7 years of age according to maternal folate levels during pregnancy in the Hokkaido Study
  Chihiro Miyashita; Atsuko Araki; Ryu Miura; Yu Ait Bamai; Sumitaka Kobayashi; Sachiko Itoh; Kumiko Ito; Meng-Shan Tsai; Reiko Kishi
  PEDIATRIC ALLERGY AND IMMUNOLOGY, 32, 3, 514, 523, Apr. 2021, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Population Attributable Fractions of Modifiable Risk Factors for Nonsyndromic Orofacial Clefts: A Prospective Cohort Study From the Japan Environment and Children's Study
  Yukihiro Sato; Eiji Yoshioka; Yasuaki Saijo; Toshinobu Miyamoto; Kazuo Sengoku; Hiroshi Azuma; Yusuke Tanahashi; Yoshiya Ito; Sumitaka Kobayashi; Machiko Minatoya; Yu Ait Bamai; Keiko Yamazaki; Sachiko Itoh; Chihiro Miyashita; Atsuko Araki; Reiko Kishi
  JOURNAL OF EPIDEMIOLOGY, 31, 4, 272, 279, Apr. 2021, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Hypertensive Disorders during Pregnancy (HDP), Maternal Characteristics, and Birth Outcomes among Japanese Women: A Hokkaido Study.
  Kritika Poudel; Sumitaka Kobayashi; Chihiro Miyashita; Atsuko Ikeda-Araki; Naomi Tamura; Yu Ait Bamai; Sachiko Itoh; Keiko Yamazaki; Hideyuki Masuda; Mariko Itoh; Kumiko Ito; Reiko Kishi
  International journal of environmental research and public health, 18, 7, 24 Mar. 2021, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Hypertension during pregnancy causes a greater risk of adverse birth outcomes worldwide; however, formal evidence of hypertensive disorders during pregnancy (HDP) in Japan is limited. We aimed to understand the association between maternal characteristics, HDP, and birth outcomes. In total, 18,833 mother-infant pairs were enrolled in the Hokkaido study on environment and children's health, Japan, from 2002 to 2013. Medical records were used to identify hypertensive disorders and birth outcomes, namely, small for gestational age (SGA), SGA at full term (term-SGA), preterm birth (PTB), and low birth weight (LBW). The prevalence of HDP was 1.9%. Similarly, the prevalence of SGA, term-SGA, PTB, and LBW were 7.1%, 6.3%, 7.4%, and 10.3%, respectively. The mothers with HDP had increased odds of giving birth to babies with SGA (2.13; 95% Confidence Interval (CI): 1.57, 2.88), PTB (3.48; 95%CI: 2.68, 4.50), LBW (3.57; 95%CI: 2.83, 4.51) than normotensive pregnancy. Elderly pregnancy, low and high body mass index, active and passive smoking exposure, and alcohol consumption were risk factors for different birth outcomes. Therefore, it is crucial for women of reproductive age and their families to be made aware of these risk factors through physician visits, health education, and various community-based health interventions.
• Secular trends of urinary phthalate metabolites in 7-year old children and association with building characteristics: Hokkaido study on environment and children's health.
  Rahel Mesfin Ketema; Yu Ait Bamai; Atsuko Ikeda-Araki; Takeshi Saito; Reiko Kishi
  International journal of hygiene and environmental health, 234, 113724, 113724, 21 Mar. 2021, [Peer-reviewed], [International Magazine]
  English, Scientific journal, The widespread commercial production and use of phthalates as plasticizers in consumer products have led to significant human exposure. Some phthalates are known to disrupt the endocrine system and result in adverse health outcomes. As such, they have been regulated in materials used for children's items and food packages. In this study, we examined the secular trend of urinary phthalate metabolites in children and the association between metabolites and building characteristics. In total, 400 first-morning spot urine samples of 7 years old children collected from 2012 to 2017 from an ongoing birth cohort study were examined. Parents provided information on demographics and building questionnaires. We analyzed 10 urinary phthalate metabolites from five phthalate diesters using ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS): MiBP, MnBP, MBzP, MEHP, MEOHP, MEHHP, MECPP, MiNP, OH-MiNP, and cx-MiNP. A multivariable regression model with creatinine-corrected metabolite levels was applied to assess secular trends during 2012-2017. The association between metabolite levels and building characteristics was investigated using a mutual-adjusted linear regression. The metabolites MnBP, MEHP, MEOHP, MEHHP, MECPP, and OH-MiNP were detected in all samples. The highest median concentration was for MECPP 37.4 ng/mL, followed by MnBP and MEHHP at concentrations of 36.8 and 25.8 ng/mL, respectively. Overall, DBP, BBzP, and DINP metabolite concentrations in this study were comparable to or lower than those in previous studies from Japan and other countries in a similar study period. Higher concentrations of DEHP metabolites were observed in this study than in children from the USA and Germany, as per previous reports. Despite updated phthalate regulations and reports of production volume change in Japan, all the measured metabolites showed a stable trend between 2012 and 2017. Higher phthalate metabolite levels were observed among children from households with low annual income, those who lived in old buildings, and those with window opening habits of ≥1 h than ≤1 h. In contrast, children in houses that vacuumed 4 or more days/week showed a lower level of MnBP than those in houses that vacuumed ≤3 days/week. This study demonstrates that the internal exposure level of phthalates in Japanese children was stable from 2012 to 2017. Our findings suggest that phthalate exposure in children is consistent. Thus, improvements in the indoor environment, such as frequent vacuuming, may reduce exposure. Biomonitoring of phthalates is critical for elucidating their possible health effects and developing mitigation strategies.
• Trajectories of the Psychological Status of Mothers of Infants With Nonsyndromic Orofacial Clefts: A Prospective Cohort Study From the Japan Environment and Children's Study
  Yukihiro Sato; Eiji Yoshioka; Yasuaki Saijo; Toshinobu Miyamoto; Kazuo Sengoku; Hiroshi Azuma; Yusuke Tanahashi; Yoshiya Ito; Sumitaka Kobayashi; Machiko Minatoya; Yu Ait Bamai; Keiko Yamazaki; Sachiko Ito; Chihiro Miyashita; Atsuko Araki; Reiko Kishi
  CLEFT PALATE-CRANIOFACIAL JOURNAL, 58, 3, 369, 377, Mar. 2021, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Lower respiratory tract infections and orofacial clefts: a prospective cohort study from the Japan Environment and Children's Study.
  Yukihiro Sato; Eiji Yoshioka; Yasuaki Saijo; Toshinobu Miyamoto; Hiroshi Azuma; Yusuke Tanahashi; Yoshiya Ito; Sumitaka Kobayashi; Machiko Minatoya; Yu Ait Bamai; Keiko Yamazaki; Sachiko Ito; Chihiro Miyashita; Atsuko Araki; Reiko Kishi
  Journal of epidemiology, 13 Jan. 2021, [Domestic magazines]
  English, Scientific journal, BACKGROUND: Lower respiratory tract infections (LRTIs) are a cause of inpatient and outpatient care among children. Although orofacial clefts seem to be associated with LRTIs, epidemiological studies are scarce on this topic. This study aimed to examine whether infants with orofacial clefts were associated with LRTIs. METHODS: This prospective cohort study used data from the Japan Environment and Children's Study, whose baseline recruitment was conducted during 2011-2014. This study included 81,535 participants. The number of infants with cleft lip and palate (CLP), cleft lip (CL), and cleft palate only (CP) was 67, 49, and 36, respectively. We defined history of LRTIs until 12 months' age reported by their mothers as the dependent variable. Accumulated breastfeeding duration was used as potential mediators. RESULTS: The incidence proportion of LRTIs among the control group was 6.0%. The incidence proportion among infants with CLP, CL, and CP were 11.9%, 14.3%, and 5.6%, respectively. After adjusting for covariates, compared with the control group, infants with CLP and CL were associated with risk of LRTIs (incidence risk ratio [IRR] of CLP = 2.38 [95% confidence interval = 1.30, 4.36] and of CL = 2.73 [1.40, 5.33]) , but not ones with CP (1.08 [0.28, 4.15]). Accumulated breastfeeding duration decreased the IRR of CLP only (IRR of CLP = 2.16 [1.19, 3.93]). CONCLUSIONS: Infants with orofacial clefts aged 1 year have a potentially high incidence proportion of LRTIs. Accumulated breastfeeding duration might mediate the associations of CLP.
• Occupational exposure limits for acetaldehyde, 2‐bromopropane, glyphosate, manganese and inorganic manganese compounds, and zinc oxide nanoparticle, and the biological exposure indices for cadmium and cadmium compounds and ethylbenzene, and carcinogenicity, occupational sensitizer, and reproductive toxicant classifications
  Atsuko Araki; Kenichi Azuma; Ginji Endo; Yoko Endo; Tetsuhito Fukushima; Kunio Hara; Kouji Harada; Hajime Hori; Seichi Horie; Hyogo Horiguchi; Masayoshi Ichiba; Gaku Ichihara; Tatsuya Ishitake; Akiyoshi Ito; Yuki Ito; Satoko Iwasawa; Takeyasu Kakamu; Michihiro Kamijima; Kanae Karita; Toshio Kawai; Toshihiro Kawamoto; Reiko Kishi; Shinji Kumagai; Akiko Matsumoto; Muneyuki Miyagawa; Hiroyuki Miyauchi; Yasuo Morimoto; Kasuke Nagano; Hisao Naito; Tamie Nakajima; Makiko Nakano; Tetsuo Nomiyama; Hirokazu Okuda; Masayuki Okuda; Kazuyuki Omae; Kazuhiro Sato; Tomotaka Sobue; Yasushi Suwazono; Toru Takebayashi; Tatsuya Takeshita; Akito Takeuchi; Ayano Takeuchi; Shigeru Tanaka; Mayumi Tsuji; Teruomi Tsukahara; Susumu Ueno; Jun Ueyama; Yumi Umeda; Kenya Yamamoto; Yuko Yamano; Takenori Yamauchi; Eiji Yano
  Journal of Occupational Health, 63, 1, Wiley, Jan. 2021
  Scientific journal
• Short-term temporal variability of urinary biomarkers of organophosphate flame retardants and plasticizers
  Michiel Bastiaensen; Celine Gys; Govindan Malarvannan; Mihai Fotache; Jasper Bombeke; Yu Ait Bamai; Atsuko Araki; Adrian Covaci
  ENVIRONMENT INTERNATIONAL, 146, Jan. 2021, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal
• Short-term variability of bisphenols in spot, morning void and 24-hour urine samples
  Celine Gys; Michiel Bastiaensen; Govindan Malarvannan; Yu Ait Bamai; Atsuko Araki; Adrian Covaci
  ENVIRONMENTAL POLLUTION, 268, Jan. 2021, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal
• Mediating Factors Between Parental Socioeconomic Status and Small for Gestational Age in Infants: Results from the Hokkaido Study on Environment and Children's Health
  Naomi Tamura; Tomoyuki Hanaoka; Kumiko Ito; Atsuko Araki; Chihiro Miyashita; Sachiko Ito; Sumitaka Kobayashi; Yoichi Ito; Hisanori Minakami; Kazutoshi Cho; Toshiaki Endo; Tsuyoshi Baba; Kazuo Sengoku; Toshinobu Miyamoto; Katsuhiko Ogasawara; Reiko Kishi
  MATERNAL AND CHILD HEALTH JOURNAL, 25, 4, 645, 655, Jan. 2021, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Between- and within-individual variability of urinary phthalate and alternative plasticizer metabolites in spot, morning void and 24-h pooled urine samples
  Michiel Bastiaensen; Govindan Malarvannan; Celine Gys; Yu Ait Bamai; Atsuko Araki; Adrian Covaci
  ENVIRONMENTAL RESEARCH, 191, 110248, 110248, Dec. 2020, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal
• Biomonitoring and temporal trends of bisphenols exposure in Japanese school children
  Celine Gys; Yu Ait Bamai; Atsuko Araki; Michiel Bastiaensen; Noelia Caballero-Casero; Reiko Kishi; Adrian Covaci
  ENVIRONMENTAL RESEARCH, 191, 110172, 110172, Dec. 2020, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal
• Exposure to Radiofrequency Electromagnetic Field in the High-Frequency Band and Cognitive Function in Children and Adolescents: A Literature Review
  Toru Ishihara; Keiko Yamazaki; Atsuko Araki; Yuri Teraoka; Naomi Tamura; Takashi Hikage; Manabu Omiya; Masahiro Mizuta; Reiko Kishi
  INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 17, 24, 9179, 9179, Dec. 2020, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Effect of the occupational environment of parents on cryptorchidism
  Takahiko Mitsui; Atsuko Araki; Chihiro Miyashita; Sachiko Ito; Takeya Kitta; Kimihiko Moriya; Nobuo Shinohara; Masayuki Takeda; Reiko Kishi
  PEDIATRICS INTERNATIONAL, 62, 11, 1256, 1263, Nov. 2020, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Effect of prenatal exposure to per- and polyfluoroalkyl substances on childhood allergies and common infectious diseases in children up to age 7 years: The Hokkaido study on environment and children's health
  Yu Ait Bamai; Houman Goudarzi; Atsuko Araki; Emiko Okada; Ikuko Kashino; Chihiro Miyashita; Reiko Kishi
  ENVIRONMENT INTERNATIONAL, 143, Oct. 2020, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Risk factors for motor coordination problems in preschool-age children
  Satoshi Suyama; Kazuyori Yagyu; Atsuko Araki; Chihiro Miyashita; Sachiko Itoh; Machiko Minatoya; Keiko Yamazaki; Naomi Tamura; Akio Nakai; Takuya Saito; Reiko Kishi
  PEDIATRICS INTERNATIONAL, 62, 10, 1177, 1183, Oct. 2020, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Associations between prenatal exposure to organochlorine pesticides and thyroid hormone levels in mothers and infants: The Hokkaido study on environment and children's health
  Keiko Yamazaki; Sachiko Itoh; Atsuko Araki; Chihiro Miyashita; Machiko Minatoya; Tamiko Ikeno; Shizue Kato; Kaori Fujikura; Futoshi Mizutani; Yoichi Chisaki; Reiko Kishi
  ENVIRONMENTAL RESEARCH, 189, Oct. 2020, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Lifestyle behaviors and home and school environment in association with sick building syndrome among elementary school children: a cross-sectional study
  Rahel Mesfin Ketema; Atsuko Araki; Yu Ait Bamai; Takeshi Saito; Reiko Kishi
  ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE, 25, 1, Jul. 2020, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Temporal trends and determinants of PFR exposure in the Hokkaido Study
  Michiel Bastiaensen; Yu Ait Bamai; Atsuko Araki; Houman Goudarzi; Satoshi Konno; Sachiko Ito; Chihiro Miyashita; Yiming Yao; Reiko Kishi; Adrian Covaci
  INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH, 228, 113523, 113523, Jul. 2020, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal
• Association of exposure to prenatal phthalate esters and bisphenol A and polymorphisms in the ESR1 gene with the second to fourth digit ratio in school-aged children: Data from the Hokkaido study
  Yoko Nishimura; Kimihiko Moriya; Sumitaka Kobayashi; Atsuko Araki; Fumihiro Sata; Takahiko Mitsui; Sachiko Itoh; Chihiro Miyashita; Kazutoshi Cho; Masafumi Kon; Michiko Nakamura; Takeya Kitta; Sachiyo Murai; Reiko Kishi; Nobuo Shinohara
  STEROIDS, 159, 108637, 108637, Jul. 2020, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Factors correlating with serum birch pollen IgE status in pregnant women in Hokkaido, Japan: The Japan Environment and Children's Study (JECS)
  Yasuaki Saijo; Eiji Yoshioka; Yukihiro Sato; Toshinobu Miyamoto; Kazuo Sengoku; Yoshiya Ito; Sachiko Itoh; Chihiro Miyashita; Atsuko Araki; Reiko Kishi
  WORLD ALLERGY ORGANIZATION JOURNAL, 13, 6, 100128, 100128, Jun. 2020, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Combined exposure to phthalate esters and phosphate flame retardants and plasticizers and their associations with wheeze and allergy symptoms among school children
  Atsuko Araki; Yu Ait Bamai; Michiel Bastiaensen; Nele Van den Eede; Toshio Kawai; Tazuru Tsuboi; Chihiro Miyashita; Sachiko Itoh; Houman Goudarzi; Satoshi Konno; Adrian Covaci; Reiko Kishi
  ENVIRONMENTAL RESEARCH, 183, 109212, 109212, Apr. 2020, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal
• Prenatal exposure to 11 perfluoroalkyl substances and fetal growth: A large-scale, prospective birth cohort study
  Ikuko Kashino; Seiko Sasaki; Emiko Okada; Hideyuki Matsuura; Houman Goudarzi; Chihiro Miyashita; Eisaku Okada; Yoichi M. Ito; Atsuko Araki; Reiko Kishi
  ENVIRONMENT INTERNATIONAL, 136, 105355, 105355, Mar. 2020, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Early-Life Environmental Influences on Allergic Diseases
  Ait Bamai, Y.; Miyashita, C.; Araki, A.; Kishi, R.
  Early-life Environmental Exposure and Disease: Facts and Perspectives, 2020
  Scientific journal
• Occupational exposure limits for ethyl benzene, dimethyl terephthalate and hydrogen fluoride, and carcinogenicity and reproductive toxicant classifications The Committee for Recommendation of Occupational Exposure Limits, Japan Society for Occupational Health
  Atsuko Araki; Kenichi Azuma; Ginji Endo; Yoko Endo; Tetsuhito Fukushima; Kunio Hara; Hajime Hori; Masayoshi Ichiba; Tatsuya Ishitake; Gaku Ichihara; Akiyoshi Ito; Yuki Ito; Satoko Iwasawa; Takeyasu Kakamu; Michihiro Kamijima; Kanae Karita; Takahiko Katoh; Toshio Kawai; Toshihiro Kawamoto; Reiko Kishi; Shinji Kumagai; Yukinori Kusaka; Muneyuki Miyagawa; Hiroyuki Miyauchi; Yasuo Morimoto; Kasuke Nagano; Hisao Naito; Tamie Nakajima; Makiko Nakano; Tetsuo Nomiyama; Hirokazu Okuda; Masayuki Okuda; Kazuyuki Omae; Kazuhiro Sato; Tomotaka Sobue; Yasushi Suwazono; Toru Takebayashi; Tatsuya Takeshita; Teruomi Tsukahara; Masashi Tsunoda; Jun Ueyama; Yumi Umeda; Kenya Yamamoto; Yuko Yamano; Takenori Yamauchi; Eiji Yano
  JOURNAL OF OCCUPATIONAL HEALTH, 62, 1, Jan. 2020
  English
• Cat and Dog Ownership in Early Life and Infant Development: A Prospective Birth Cohort Study of Japan Environment and Children's Study.
  Machiko Minatoya; Atsuko Araki; Chihiro Miyashita; Sachiko Itoh; Sumitaka Kobayashi; Keiko Yamazaki; Yu Ait Bamai; Yasuaki Saijyo; Yoshiya Ito; Reiko Kishi; The Japan Environment And Children's Study Group
  International journal of environmental research and public health, 17, 1, 27 Dec. 2019, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Contact with companion animals has been suggested to have important roles in enhancing child development. However, studies focused on child development and pet ownership at a very early age are limited. The purpose of the current study was to investigate child development in relation to pet ownership at an early age in a nationwide prospective birth cohort study: the Japan Environment and Children's Study. Associations between cat and dog ownership at six months and infant development at 12 months of age were examined in this study. Infant development was assessed using the Ages & Stages QuestionnairesTM (ASQ-3) at 12 months. Among participants of (Japan Environment and Children's Study) JECS, those with available data of cat and dog ownership at six months and data for the ASQ-3 at 12 months were included (n = 78,868). Having dogs showed higher percentages of pass in all five domains measured by ASQ-3 (communication, gross motor, fine motor, problem-solving, and personal-social) compared to those who did not have dogs. Significantly decreased odds ratios (ORs) of developmental delays were observed in association with having dogs in all fix domains (communication: OR = 0.73, gross motor: OR = 0.86, fine motor: OR = 0.84, problem-solving: OR = 0.90, personal-social: OR = 0.83). This study suggested that early life dog ownership may reduce the risks of child developmental delays.
• Prenatal tobacco exposure and ADHD symptoms at pre-school age: the Hokkaido Study on Environment and Children's Health
  Machiko Minatoya; Atsuko Araki; Sachiko Itoh; Keiko Yamazaki; Sumitaka Kobayashi; Chihiro Miyashita; Seiko Sasaki; Reiko Kishi
  ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE, 24, 1, 74, 74, Dec. 2019, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Multiple exposures to organophosphate flame retardants alter urinary oxidative stress biomarkers among children: The Hokkaido Study
  Yu Ait Bamai; Michiel Bastiaensen; Atsuko Araki; Houman Goudarzi; Satoshi Konno; Sachiko Ito; Chihiro Miyashita; Yiming Yao; Adrian Covaci; Reiko Kishi
  ENVIRONMENT INTERNATIONAL, 131, 105003, 105003, Oct. 2019, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal
• Childhood allergies and obesity relationship: Identification of novel non-invasive biomarkers
  Houman Goudarzi; Satoshi Konno; Atsuko Araki; Sachiko Ito; Yu Ait Bamai; Chihiro Miyashita; Reiko Kishi
  EUROPEAN RESPIRATORY JOURNAL, 54, Sep. 2019
  English
• Association between perfluoroalkyl substance exposure and thyroid hormone/thyroid antibody levels in maternal and cord blood: The Hokkaido Study.
  Itoh S; Araki A; Miyashita C; Yamazaki K; Goudarzi H; Minatoya M; Ait Bamai Y; Kobayashi S; Okada E; Kashino I; Yuasa M; Baba T; Kishi R
  Environment international, 133, Pt A, 105139, 105139, Sep. 2019, [Peer-reviewed], [International Magazine]
  English, Scientific journal, BACKGROUND: Thyroid antibodies (TAs) are the most common cause of hypothyroidism during gestation. Although previous studies found that prenatal exposure to perfluoroalkyl substances (PFASs) disrupts thyroid hormones (THs) in humans, their effects on TAs during the perinatal period have not been investigated. OBJECTIVE: To explore the associations between prenatal exposure to eleven different PFASs from two different groups (carboxylates and sulfonates) and the expression of THs and TAs in maternal and cord blood while considering maternal TA status. METHODS: In a prospective birth cohort (the Hokkaido Study), we included 701 mother‑neonate pairs recruited in 2002-2005 for whom both prenatal maternal and cord blood samples were available. Eleven PFASs were measured in maternal plasma obtained at 28-32 weeks of gestation using ultra-performance liquid chromatography coupled with triple quadrupole tandem mass spectrometry. THs and TAs including thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), thyroid peroxidase antibody (TPOAb), and thyroglobulin antibody (TgAb) were measured in maternal blood during early pregnancy (median 11 gestational weeks), and in cord blood at birth. RESULTS: The median levels of TgAb and TPOAb in maternal serum were 15.0 and 6.0 IU/mL, respectively. The median TgAb level in neonates was 38.0 IU/mL, and TPOAb were detected in only 12.3% of samples. Maternal FT3 level was positively associated with PFAS levels in both TA-positive and TA-negative mothers. Maternal perfluorooctanoate was inversely associated with maternal TPOAb. Among boys, some maternal PFASs were associated with higher TSH and lower FT3 levels in maternal TA-negative group, while perfluorodecanoic acid was associated with lower TSH in maternal TA-positive group. Among girls, some PFAS of mothers showed associations with lower TSH and higher FT3 in maternal TA-negative group, while perfluorododecanoic acid was associated with lower FT4 in maternal TA-positive. Maternal PFASs showed associations with boy's TgAb inversely in maternal TA-negative group and with girl's TgAb positively in maternal TA-positive group. CONCLUSIONS: Our results suggest thyroid disrupting effects of PFAS exposure and susceptibility vary depending on maternal TA levels.
• An epigenome-wide analysis of cord blood DNA methylation reveals sex-specific effect of exposure to bisphenol A
  Ryu Miura; Atsuko Araki; Machiko Minatoya; Kunio Miyake; Mei-Lien Chen; Sumitaka Kobayashi; Chihiro Miyashita; Jun Yamamoto; Toru Matsumura; Mayumi Ishizuka; Takeo Kubota; Reiko Kishi
  SCIENTIFIC REPORTS, 9, 1, 12369, Aug. 2019, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Occupational exposure limits for cumene, 2,4-dichlorophenoxy acetic acid, silicon carbide whisker, benzyl alcohol, and methylamine, and carcinogenicity, occupational sensitizer, and reproductive toxicant classifications
  Atsuko Araki; Kenichi Azuma; Ginji Endo; Yoko Endo; Tetsuhito Fukushima; Kunio Hara; Koji Harada; Hajime Hori; Seichi Horie; Masayoshi Ichiba; Gaku Ichihara; Masayuki Ikeda; Akiyoshi Ito; Yuki Ito; Satoko Iwasawa; Takeyasu Kakumu; Michihiro Kamijima; Kanae Karita; Takahiko Katoh; Toshio Kawai; Toshihiro Kawamoto; Shinji Kumagai; Yukinori Kusaka; Akiko Matsumoto; Muneyuki Miyagawa; Hiroyuki Miyauchi; Yasuo Morimoto; Kasuke Nagano; Hisao Naito; Tamie Nakajima; Makiko Nakano; Tetsuo Nomiyama; Hirokazu Okuda; Masayuki Okuda; Kazuyuki Omae; Haruhiko Sakurai; Kazuhiro Sato; Tomotaka Sobue; Yasushi Suwazono; Toru Takebayashi; Tatsuya Takeshita; Akito Takeuchi; Ayano Takeuchi; Masatoshi Tanaka; Shigeru Tanaka; Teruomi Tsukahara; Masashi Tsunoda; Susumu Ueno; Jun Ueyama; Yumi Umeda; Kenya Yamamoto; Yuko Yamano; Takenori Yamauchi; Eiji Yano
  JOURNAL OF OCCUPATIONAL HEALTH, 61, 4, 328, 330, Jul. 2019, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• The relationship between prenatal psychological stress and placental abruption in Japan, The Japan Environment and Children's Study (JECS)
  Yasuyuki Kawanishi; Eiji Yoshioka; Yasuaki Sago; Toshihiro Itoh; Toshinobu Miyamoto; Kazuo Sengoku; Yoshiya Ito; Sachiko Ito; Chihiro Miyashita; Atsuko Araki; Toshiaki Endo; Kazutoshi Cho; Hisanori Minakami; Reiko Kishi; Toshihiro Kawamoto; Hirohisa Saito; Reiko Kishi; Nobuo Yaegashi; Koichi Hashimoto; Chisato Mori; Shuichi Ito; Zentaro Yamagata; Hidekuni Inadera; Michihiro Kamijima; Takeo Nakayama; Hiroyasu Iso; Masayuki Shima; Yasuaki Hirooka; Narufumi Suganuma; Koichi Kusuhara; Takahiko Katoh
  PLOS ONE, 14, 7, e0219379, Jul. 2019, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Association between maternal passive smoking and increased risk of delivering small-for-gestational-age infants at full-term using plasma cotinine levels from The Hokkaido Study: a prospective birth cohort
  Sumitaka Kobayashi; Fumihiro Sata; Tomoyuki Hanaoka; Titilola Serifat Braimoh; Kumiko Ito; Naomi Tamura; Atsuko Araki; Sachiko Itoh; Chihiro Miyashita; Reiko Kishi
  BMJ OPEN, 9, 2, e023200, Jun. 2019, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Biomonitoring of organophosphate flame retardants and plasticizers in children: Associations with house dust and housing characteristics in Japan
  Michiel Bastiaensen; Yu Ait Bamai; Atsuko Araki; Nele Van den Eede; Toshio Kawai; Tazuru Tsuboi; Reiko Kishi; Adrian Covaci
  ENVIRONMENTAL RESEARCH, 172, 543, 551, May 2019, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal
• Dose-dependent associations between prenatal caffeine consumption and small for gestational age, preterm birth, and reduced birthweight in the Japan Environment and Children's Study
  Sumitaka Kobayashi; Fumihiro Sata; Katsuyuki Murata; Yasuaki Saijo; Atsuko Araki; Chihiro Miyashita; Sachiko Itoh; Machiko Minatoya; Keiko Yamazaki; Yu Ait Bamai; Reiko Kishi; Toshihiro Kawamoto; Hirohisa Saito; Reiko Kishi; Nobuo Yaegashi; Koichi Hashimoto; Chisato Mori; Shuichi Itoh; Zentaro Yamagata; Hidekuni Inadera; Michihiro Kamijima; Takeo Nakayama; Hiroyasu Iso; Masayuki Shima; Yasuaki Hirooka; Narufumi Suganuma; Koichi Kusuhara; Takahiko Katoh
  PAEDIATRIC AND PERINATAL EPIDEMIOLOGY, 33, 3, 185, 194, May 2019, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Association Between Maternal Serum Folate Concentrations in the First Trimester and the Risk of Birth Defects: The Hokkaido Study of Environment and Children's Health
  Kumiko Ito; Tomoyuki Hanaoka; Naomi Tamura; Seiko Sasaki; Chihiro Miyashita; Atsuko Araki; Sachiko Ito; Hisanori Minakami; Kazutoshi Cho; Toshiaki Endo; Tsuyoshi Baba; Toshinobu Miyamoto; Kazuo Sengoku; Akiko Tamakoshi; Reiko Kishi
  JOURNAL OF EPIDEMIOLOGY, 29, 4, 164, 171, Apr. 2019, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Association of blood mercury levels during pregnancy with infant birth size by blood selenium levels in the Japan Environment and Children's Study: A prospective birth cohort
  Sumitaka Kobayashi; Reiko Kishi; Yasuaki Saijo; Yoshiya Ito; Koji Oba; Atsuko Araki; Chihiro Miyashita; Sachiko Itoh; Machiko Minatoya; Keiko Yamazaki; Yu Ait Bamai; Tosiya Sato; Shin Yamazaki; Shoji F. Nakayama; Tomohiko Isobe; Hiroshi Nitta; Toshihiro Kawamoto; Hirohisa Saito; Nobuo Yaegashi; Koichi Hashimoto; Chisato Mori; Shuichi Itoh; Zentaro Yamagata; Hidekuni Inadera; Michihiro Kamijima; Takeo Nakayama; Hiroyasu Iso; Masayuki Shima; Yasuaki Hirooka; Narufumi Suganuma; Koichi Kusuhara; Takahiko Katoh
  ENVIRONMENT INTERNATIONAL, 125, 418, 429, Apr. 2019, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• For making a declaration of countermeasures against the falling birth rate from the Japanese Society for Hygiene: summary of discussion in the working group on academic research strategy against an aging society with low birth rate
  Kyoko Nomura; Kanae Karita; Atsuko Araki; Emiko Nishioka; Go Muto; Miyuki Iwai-Shimada; Mariko Nishikitani; Mariko Inoue; Shinobu Tsurugano; Naomi Kitano; Mayumi Tsuji; Sachiko Iijima; Kayo Ueda; Michihiro Kamijima; Zentaro Yamagata; Kiyomi Sakata; Masayuki Iki; Hiroyuki Yanagisawa; Masashi Kato; Hidekuni Inadera; Yoshihiro Kokubo; Kazuhito Yokoyama; Akio Koizumi; Takemi Otsuki
  ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE, 24, 1, 14, 14, Mar. 2019, [Peer-reviewed], [International Magazine]
  English
• Effects of prenatal sex hormones on behavioral sexual dimorphism
  Takahiko Mitsui; Atsuko Araki; Chihiro Miyashita; Sachiko Ito; Tamiko Ikeno; Seiko Sasaki; Takeya Kitta; Kimihiko Moriya; Kazutoshi Cho; Keita Morioka; Reiko Kishi; Nobuo Shinohara; Masayuki Takeda; Katsuya Nonomura
  PEDIATRICS INTERNATIONAL, 61, 2, 140, 146, Feb. 2019, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• A risk score for childhood obesity constructed using predictors identified in pregnant women and 1-year-old infants: the Hokkaido
  Saijo Y; Ito Y; Yoshioka E; Sato Y; Minatoya M; Araki A; Miyashita C; Kishi R
  Clinical Pediatric Endocrinology, -, -, -, -, 2019, [Peer-reviewed], [International Magazine]
  Scientific journal
• Chapter 9: The Hokkaido Study on Environment and Children’s Health, Part 3: Public Health Aspect in Each Cohort or Consortium. in Fumihiro Sata, Hideoki Fukuoka, Mark Hanson (Eds.)
  Kishi R; Araki A; Miyashita C; Kobayashi S; Miura R; Minatoya M
  Pre-emptive Medicine: Public Health Aspects of Developmental Origins of Health and Disease. Springer, -, -, 145, 163, 2019, [Peer-reviewed]
  Scientific journal
• Identifying a risk score for childhood obesity based on predictors identified in pregnant women and 1-year-old infants: An analysis of the data of the Hokkaido Study on Environment and Children's Health
  Yasuaki Saijo; Yoshiya Ito; Eiji Yoshioka; Yukihiro Sato; Machiko Minatoya; Atsuko Araki; Chihiro Miyashita; Reiko Kishi
  CLINICAL PEDIATRIC ENDOCRINOLOGY, 28, 3, 81, 89, 2019, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Association between ESR1 polymorphisms and second to fourth digit ratio in school-aged children in the Hokkaido Study
  Yoko Nishimura; Kimihiko Moriya; Sumitaka Kobayashi; Atsuko Araki; Fumihiro Sata; Takahiko Mitsui; Sachiko Itoh; Chihiro Miyashita; Kazutoshi Cho; Masafumi Kon; Michiko Nakamura; Takeya Kitta; Sachiyo Murai; Reiko Kishi; Nobuo Shinohara
  STEROIDS, 141, 55, 62, Jan. 2019, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• [Toward a Declaration to Address Japan's Aging Society with Low Birth Rate: Summary of the Japanese Society for Hygiene's Working Group on Academic Research Strategy against an Aging Society with Low Birth Rate].
  Kyoko Nomura; Kanae Karita; Atsuko Araki; Emiko Nishioka; Go Muto; Miyuki Iwai-Shimada; Mariko Nishikitani; Mariko Inoue; Shinobu Tsurugano; Naomi Kitano; Mayumi Tsuji; Sachiko Iijima; Kayo Ueda; Michihiro Kamijima; Zentaro Yamagata; Kiyomi Sakata; Masayuki Iki; Hiroyuki Yanagisawa; Masashi Kato; Kazuhito Yokoyama; Akio Koizumi; Takemi Otsuki
  Nihon eiseigaku zasshi. Japanese journal of hygiene, 74, 0, 2019, [Peer-reviewed], [Domestic magazines]
  Japanese, Scientific journal
• Association of filaggrin gene mutations and childhood eczema and wheeze with phthalates and phosphorus flame retardants in house dust: The Hokkaido study on Environment and Children's Health
  Yu Ait Bamai; Atsuko Araki; Toshifumi Nomura; Toshio Kawai; Tazuru Tsuboi; Sumitaka Kobayashi; Chihiro Miyashita; Masae Takeda; Hiroshi Shimizu; Reiko Kishi
  ENVIRONMENT INTERNATIONAL, 121, Pt 1, 102, 110, Dec. 2018, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Association between prenatal exposure to organochlorine pesticides and the mental and psychomotor development of infants at ages 6 and 18 months: The Hokkaido Study on Environment and Children's Health
  Keiko Yamazaki; Atsuko Araki; Sonomi Nakajima; Chihiro Miyashita; Tamiko Ikeno; Sachiko Itoh; Machiko Minatoya; Sumitaka Kobayashi; Futoshi Mizutani; Yoichi Chisaki; Reiko Kishi
  NEUROTOXICOLOGY, 69, 201, 208, Dec. 2018, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Association of maternal serum concentration of hydroxylated polychlorinated biphenyls with maternal and neonatal thyroid hormones: The Hokkaido birth cohort study
  Sachiko Itoh; Toshiaki Baba; Motoyuki Yuasa; Chihiro Miyashita; Sumitaka Kobayashi; Atsuko Araki; Seiko Sasaki; Jumboku Kajiwara; Tsuguhide Hori; Takashi Todaka; Kaori Fujikura; Sonomi Nakajima; Shizue Kato; Reiko Kishi
  ENVIRONMENTAL RESEARCH, 167, 583, 590, Nov. 2018, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Contrasting associations of maternal smoking and pre-pregnancy BMI with wheeze and eczema in children
  Houman Goudarzi; Satoshi Konno; Hirokazu Kimura; Atsuko Araki; Chihiro Miyashita; Sachiko Itoh; Yu Ait Bamai; Hiroki Kimura; Kaoruko Shimizu; Masaru Suzuki; Yoichi M. Ito; Masaharu Nishimura; Reiko Kishi
  SCIENCE OF THE TOTAL ENVIRONMENT, 639, 1601, 1609, Oct. 2018, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Associations between allergic symptoms and phosphate flame retardants in dust and their urinary metabolites among school children
  Atsuko Araki; Michiel Bastiaensen; Yu Ait Bamai; Nele Van den Eede; Toshio Kawai; Tazuru Tsuboi; Rahel Mesfin Ketema; Adrian Covaci; Reiko Kishi
  ENVIRONMENT INTERNATIONAL, 119, 438, 446, Oct. 2018, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal
• Prenatal exposure to bisphenol A and phthalates and behavioral problems in children at preschool age: the Hokkaido Study on Environment and Children's Health
  Machiko Minatoya; Sachiko Itoh; Keiko Yamazaki; Atsuko Araki; Chihiro Miyashita; Naomi Tamura; Jun Yamamoto; Yu Onoda; Kazuki Ogasawara; Toru Matsumura; Reiko Kishi
  ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE, 23, 1, 43, 43, Sep. 2018, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Sex-related differences in the associations between maternal dioxin-like compounds and reproductive and steroid hormones in cord blood: The Hokkaido study
  Chihiro Miyashita; Atsuko Araki; Takahiko Mitsui; Sachiko Itoh; Houman Goudarzi; Seiko Sasaki; Jumboku Kajiwara; Tsuguhide Hori; Kazutoshi Cho; Kimihiko Moriya; Nobuo Shinohara; Katsuya Nonomura; Reiko Kishi
  ENVIRONMENT INTERNATIONAL, 117, 175, 185, Aug. 2018, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Relationship between adrenal steroid hormones in cord blood and birth weight: The Sapporo Cohort, Hokkaido Study on Environment and Children's Health
  Takahiko Mitsui; Atsuko Araki; Houman Goudarzi; Chihiro Miyashita; Sachiko Ito; Seiko Sasaki; Takeya Kitta; Kimihiko Moriya; Kazutoshi Cho; Keita Morioka; Reiko Kishi; Nobuo Shinohara; Masayuki Takeda; Katsuya Nonomura
  AMERICAN JOURNAL OF HUMAN BIOLOGY, 30, 4, e23127, Jul. 2018, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Occupational Exposure Limits for ethylidene norbornene, ethyleneimine, benomyl, and 2,3-epoxypropyl methacrylate, and classifications on carcinogenicity
  Atsuko Araki; Kenichi Azuma; Ginji Endo; Yoko Endo; Tetsuhito Fukushima; Kunio Hara; Hajime Hori; Seichi Horie; Hyogo Horiguchi; Masayoshi Ichiba; Gaku Ichihara; Masayuki Ikeda; Tatsuya Ishitake; Akiyoshi Ito; Yuki Ito; Satoko Iwasawa; Takeyasu Kakumu; Michihiro Kamijima; Kanae Karita; Takahiko Katoh; Toshio Kawai; Toshihiro Kawamoto; Shinji Kumagai; Yukinori Kusaka; Akiko Matsumoto; Muneyuki Miyagawa; Hiroyuki Miyauchi; Yasuo Morimoto; Kasuke Nagano; Hisao Naito; Tamie Nakajima; Makiko Nakano; Tetsuo Nomiyama; Hirokazu Okuda; Masayuki Okuda; Kazuyuki Omae; Haruhiko Sakurai; Kazuhiro Sato; Tomotaka Sobue; Yasushi Suwazono; Toru Takebayashi; Tatsuya Takeshita; Akito Takeuchi; Ayano Takeuchi; Masatoshi Tanaka; Shigeru Tanaka; Teruomi Tsukahara; Masashi Tsunoda; Susumu Ueno; Jun Ueyama; Yumi Umeda; Kenya Yamamoto; Yuko Yamano; Takenori Yamauchi; Eiji Yano
  JOURNAL OF OCCUPATIONAL HEALTH, 60, 4, 333, 335, Jul. 2018, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• An epigenome-wide study of cord blood DNA methylations in relation to prenatal perfluoroalkyl substance exposure: The Hokkaido study
  Ryu Miura; Atsuko Araki; Chihiro Miyashita; Sumitaka Kobayashi; Sachiko Kobayashi; Shu-Li Wang; Chung-Hsing Chen; Kunio Miyake; Mayumi Ishizuka; Yusuke Iwasaki; Yoichi M. Ito; Takeo Kubota; Reiko Kishi
  ENVIRONMENT INTERNATIONAL, 115, 21, 28, Jun. 2018, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• 母親の喫煙およびBMIと小児の喘鳴および湿疹との対照的な関連性(Contrasting associations of maternal smoking and BMI with wheeze and eczema in children)
  Goudarzi Houman; Konno Satoshi; Kimura Hirokazu; Araki Atsuko; Miyashita Chihiro; Itou Sachiko; Bamai Yu Ait; Kimura Hiroki; Shimizu Kaoruko; Suzuki Masaru; Ito Yoichi; Nishimura Masaharu; Kishi Reiko
  アレルギー, 67, 4-5, 509, 509, (一社)日本アレルギー学会, May 2018
  English
• 【住環境における健康リスク要因とそのマネジメント】 科学的エビデンスに基づく『新シックハウス症候群に関する相談と対策マニュアル(改訂新版)』を作成して
  岸 玲子; 吉野 博; 荒木 敦子; 西條 泰明; 東 賢一; 河合 俊夫; 大和 浩; 大澤 元毅; 柴田 英治; 田中 正敏; 増地 あゆみ; 湊屋 街子; アイツバマイ ゆふ
  日本衛生学雑誌, 73, 2, 116, 129, (一社)日本衛生学会, May 2018, [Peer-reviewed], [Domestic magazines]
  Japanese, 科学的エビデンスに基づく「新シックハウス症候群に関する相談と対策マニュアル(改訂新版)」を作成したので紹介した。このマニュアルでは、近年震災や豪雨等の災害に伴って入居者が増えている仮設住宅の問題や、地球温暖化による熱中症と室内環境などの最近の問題、電磁過敏症に関する系統的レビューについて記載した。また、快適で健康な建物を実現する上で必要な基礎的な理論、設計の考え方と方法、建物の使い方、設備の調整の方法や扱い方についても解説した。
• Indoor environmental pollutants and their association with sick house syndrome among adults and children in elementary school
  Reiko Kishi; Rahel Mesfin Ketema; Yu Ait Bamai; Atsuko Araki; Toshio Kawai; Tazuru Tsuboi; Ikue Saito; Eiji Yoshioka; Takeshi Saito
  BUILDING AND ENVIRONMENT, 136, 293, 301, May 2018, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Determinants and Temporal Trends of Perfluoroalkyl Substances in Pregnant Women: The Hokkaido Study on Environment and Children's Health
  Meng-Shan Tsai; Chihiro Miyashita; Atsuko Araki; Sachiko Itoh; Yu Ait Bamai; Houman Goudarzi; Emiko Okada; Ikuko Kashino; Hideyuki Matsuura; Reiko Kishi
  INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 15, 5, May 2018, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal
• Association between DNA methylation in cord blood and maternal smoking: The Hokkaido Study on Environment and Children's Health
  Kunio Miyake; Akio Kawaguchi; Ryu Miura; Sachiko Kobayashi; Nguyen Quoc Vuong Tran; Sumitaka Kobayashi; Chihiro Miyashita; Atsuko Araki; Takeo Kubota; Zentaro Yamagata; Reiko Kishi
  SCIENTIFIC REPORTS, 8, 1, 5654, Apr. 2018, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Effects of prenatal di(2-ethylhexyl) phthalate exposure on childhood allergies and infectious diseases: The Hokkaido Study on Environment and Children's Health
  Yu Ait Bamai; Chihiro Miyashita; Atsuko Araki; Tamie Nakajima; Seiko Sasaki; Reiko Kishi
  SCIENCE OF THE TOTAL ENVIRONMENT, 618, 1408, 1415, Mar. 2018, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Different Risk Factors for Very Low Birth Weight, Term-Small-for-Gestational-Age, or Preterm Birth in Japan
  Naomi Tamura; Tomoyuki Hanaoka; Kumiko Ito; Atsuko Araki; Chihiro Miyashita; Sachiko Ito; Hisanori Minakami; Kazutoshi Cho; Toshiaki Endo; Kazuo Sengoku; Katsuhiko Ogasawara; Reiko Kishi
  INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 15, 2, Feb. 2018, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Association between prenatal bisphenol A and phthalate exposures and fetal metabolic related biomarkers: The Hokkaido study on Environment and Children's Health
  Machiko Minatoya; Atsuko Araki; Chihiro Miyashita; Yu Ait Bamai; Sachiko Itoh; Jun Yamamoto; Yu Onoda; Kazuki Ogasawara; Toru Matsumura; Reiko Kishi
  ENVIRONMENTAL RESEARCH, 161, 505, 511, Feb. 2018, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Birth cohorts in Asia: The importance, advantages, and disadvantages of different-sized cohorts
  Reiko Kishi; Atsuko Araki; Machiko Minatoya; Sachiko Itoh; Houman Goudarzi; Chihiro Miyashita
  SCIENCE OF THE TOTAL ENVIRONMENT, 615, 1143, 1154, Feb. 2018, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Association of prenatal exposure to PCDD/Fs and PCBs with maternal and infant thyroid hormones: The Hokkaido Study on Environment and Children's Health
  Toshiaki Baba; Sachiko Ito; Motoyuki Yuasa; Eiji Yoshioka; Chihiro Miyashita; Atsuko Araki; Seiko Sasaki; Sumitaka Kobayashi; Jumboku Kajiwara; Tsuguhide Hori; Shizue Kato; Reiko Kishi
  SCIENCE OF THE TOTAL ENVIRONMENT, 615, 1239, 1246, Feb. 2018, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Association between Fetal Adipokines and Child Behavioral Problems at Preschool Age: The Hokkaido Study on Environment and Children's Health
  Machiko Minatoya; Sachiko Itoh; Atsuko Araki; Naomi Tamura; Keiko Yamazaki; Chihiro Miyashita; Reiko Kishi
  INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 15, 1, Jan. 2018, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• [New Scientific Evidence-based Public Health Guidelines and Practical Manual for Prevention of Sick House Syndrome].
  Reiko Kishi; Hiroshi Yoshino; Atsuko Araki; Yasuaki Saijo; Kenichi Azuma; Toshio Kawai; Hiroshi Yamato; Haruki Osawa; Eiji Shibata; Masatoshi Tanaka; Ayumi Masuchi; Machiko Minatoya; Yu Ait Bamai
  Nihon eiseigaku zasshi. Japanese journal of hygiene, 73, 2, 116, 129, 2018, [Peer-reviewed], [Domestic magazines]
  Japanese, Scientific journal, Recently, we have published a book containing evidence-based public health guidelines and a practical manual for the prevention of sick house syndrome. The manual is available through the homepage of the Ministry of Health, Labour and Welfare (http://www.mhlw.go.jp/file/06-Seisakujouhou-11130500-Shokuhinanzenbu/0000155147.pdf). It is an almost completely revised version of the 2009 version. The coauthors are 13 specialists in environmental epidemiology, exposure sciences, architecture, and risk communication. Since the 1970s, health problems caused by indoor chemicals, biological pollution, poor temperature control, humidity, and others in office buildings have been recognized as sick building syndrome (SBS) in Western countries, but in Japan it was not until the 1990s that people living in new or renovated homes started to describe a variety of nonspecific subjective symptoms such as eye, nose, and throat irritation, headache, and general fatigue. These symptoms resembled SBS and were designated "sick house syndrome (SHS)." To determine the strategy for prevention of SHS, we conducted a nationwide epidemiological study in six cities from 2003-2013 by randomly sampling 5,709 newly built houses. As a result 1,479 residents in 425 households agreed to environmental monitoring for indoor aldehydes and volatile organic compounds (VOCs). After adjustment for possible risk factors, some VOCs and formaldehyde were dose-dependently shown to be significant risk factors. We also studied the dampness of the houses, fungi, allergies, and others. This book is fully based on the scientific evidence collected through these studies and other newly obtained information, especially from the aspect of architectural engineering. In addition to SHS, we included chapters on recent information about "multi-chemical sensitivity."
• House Dust and Its Adverse Health Effects
  Araki, A.; Ait Bamai, Y.; Ketema, R.M.; Kishi, R.
  Nihon eiseigaku zasshi. Japanese journal of hygiene, 73, 2, 130, 137, 2018, [Peer-reviewed], [Domestic magazines]
  Scientific journal
• [Importance of Two Birth Cohorts (n=20,926 and n=514): 15 Years' Experience of the Hokkaido Study on Environment and Children's Health: Malformation, Development and Allergy].
  Reiko Kishi; Atsuko Araki; Chihiro Miyashita; Sachiko Itoh; Machiko Minatoya; Sumitaka Kobayashi; Keiko Yamazaki; Yu Ait Bamai; Ryu Miura; Naomi Tamura
  Nihon eiseigaku zasshi. Japanese journal of hygiene, 73, 2, 164, 177, 2018, [Peer-reviewed], [Domestic magazines]
  Japanese, Scientific journal, Since "Our Stolen Future" by Theo Colborn was published in 1996, global interest on the impact of chemical substances, such as the endocrine-disrupting action of chemicals, has increased. In Japan, "The Hokkaido Study on Environment and Children's Health: Malformation, Development and Allergy" was launched in 2001. It was a model of Japan Environment and Children's Study of the Ministry of the Environment. In a large-scale, Hokkaido cohort, we obtained the consent of 20,926 mothers at the organogenesis stage with the cooperation of 37 obstetrics clinics in Hokkaido. We tracked the effects of endocrine disruptors on developmental disorders. In a small-scale Sapporo cohort, we observed in detail the neuropsychiatric development of children with the consent of 514 mothers in their late pregnancy. We examined how prenatal exposure to low concentrations of environmental chemicals affect the development of organs and the postnatal development of children. Maternal exposure to POPs, such as PCB/dioxins and perfluorinated alkyl substances, has affected not only children's birth size, thyroid functions, and sex hormone levels, but also postnatal neurodevelopment, infection, and allergy among others. The associations of short-half-life substances, such as DEHP and BPA, with obesity, ASD, and ADHD have been investigated. Gene-environment interactions have been found for smoking, caffeine, folic acid, and PCB/dioxin. In 2015, our center was officially designated as the WHO Collaborating Centre for Environmental Health and Prevention of Chemical Hazards, and we continue to the contribute to the global perspectives of child health.
• Prenatal exposure to dioxin-like compounds is associated with decreased cord blood IgE and increased risk of wheezing in children aged up to 7 years: The Hokkaido study
  Chihiro Miyashita; Yu Ait Bamai; Atsuko Araki; Sachiko Itoh; Machiko Minatoya; Asumitaka Kobayashi; Jumboku Kajiwara; Tsuguhide Hori; Reiko Kishi
  SCIENCE OF THE TOTAL ENVIRONMENT, 610, 191, 199, Jan. 2018, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Prenatal organochlorine pesticide exposure and the disruption of steroids and reproductive hormones in cord blood: The Hokkaido study
  Atsuko Araki; Chihiro Miyashita; Takahiko Mitsui; Houman Goudarzi; Futoshi Mizutani; Youichi Chisaki; Sachiko Itoh; Seiko Sasaki; Kazutoshi Cho; Kimihiko Moriya; Nobuo Shinohara; Katsuya Nonomura; Reiko Kishi
  ENVIRONMENT INTERNATIONAL, 110, 1, 13, Jan. 2018, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Prevalence and Risk of Birth Defects Observed in a Prospective Cohort Study: The Hokkaido Study on Environment and Children's Health
  Tomoyuki Hanaoka; Naomi Tamura; Kumiko Ito; Seiko Sasaki; Atsuko Araki; Tamiko Ikeno; Chihiro Miyashita; Sachiko Ito; Hisanori Minakami; Kazutoshi Cho; Toshiaki Endo; Tsuyoshi Baba; Toshinobu Miyamoto; Kazuo Sengoku; Reiko Kishi
  JOURNAL OF EPIDEMIOLOGY, 28, 3, 125, 132, 2018, [Peer-reviewed]
  English, Scientific journal
• [Environmental Chemical Exposure and Its Effects on Infants' Reproductive Hormones].
  Atsuko Araki; Sachiko Itoh; Chihiro Miyashita; Machiko Minatoya; Reiko Kishi
  Nihon eiseigaku zasshi. Japanese journal of hygiene, 73, 3, 313, 321, 2018, [Peer-reviewed], [Domestic magazines]
  Japanese, Scientific journal, In recent years, the birthrate has been continuously declining in Japan. The main causes of the decline are social factors. On the other hand, there is increasing evidence that many environmental chemicals show endocrine disrupting properties. Thus, we hypothesized that exposure to these chemicals would also be a causal for the fertility crisis. In this review, we examined current evidence that focused on environmental chemical exposure in utero and its association with reproductive hormones in children. We have included the findings from a prospective birth cohorts, the Hokkaido Study on Environment and Children's Health Sapporo cohort. According to the literature, environmental chemical levels in utero, such as polychlorinated biphenyl, dioxins, perfluorinated chemical substances, phthalates, and bisphenol A were somewhat associated with the levels of reproductive hormones, such as testosterone, estradiol, progesterone, inhibin B, and insulin-like factor-3 in cord blood, in early childhood and adolescence. The literature also suggests the association between exposure to these chemicals and brain-sexual differentiation or the anogenital distance, which suggests the disruption of androgen shower during the developmental stage in the fetal period. There are still knowledge gaps on whether these hormones at an early stage affect the pubertal development and reproductive functions in later life. In addition, alternative chemicals are produced after banning one type. The health effects of alternative chemicals should be evaluated. Effects of exposure to a mixture of the chemicals should also be examined in future studies. In conclusion, the prevention of environmental chemical hazards in relation to human reproductive function is important. It would be one of the countermeasures to the falling birthrate caused by fertility issues.
• Association of prenatal passive smoking and metabolic gene polymorphisms with child growth from birth to 3 years of age in the Hokkaido Birth Cohort Study on Environment and Children's Health
  Titilola Serifat Braimoh; Sumitaka Kobayashi; Fumihiro Sata; Seiko Sasaki; Houman Goudarzi; Thamar Ayo Yila; Atsuko Araki; Chihiro Miyashita; Hisanori Minakami; Tsuyoshi Baba; Kazuo Sengoku; Reiko Kishi
  SCIENCE OF THE TOTAL ENVIRONMENT, 605, 995, 1002, Dec. 2017, [Peer-reviewed]
  English, Scientific journal
• Cord blood BPA level and child neurodevelopment and behavioral problems: The Hokkaido Study on Environment and Children's Health
  Machiko Minatoya; Atsuko Araki; Sonomi Nakajima; Seiko Sasaki; Chihiro Miyashita; Keiko Yamazaki; Jun Yamamoto; Toru Matumura; Reiko Kishi
  SCIENCE OF THE TOTAL ENVIRONMENT, 607, 351, 356, Dec. 2017, [Peer-reviewed]
  English, Scientific journal
• Modification of adverse health effects of maternal active and passive smoking by genetic susceptibility: Dose-dependent association of plasma cotinine with infant birth size among Japanese women-The Hokkaido Study
  Sumitaka Kobayashi; Fumihiro Sata; Seiko Sasaki; Titilola Serifat Braimoh; Atsuko Araki; Chihiro Miyashita; Houman Goudarzi; Sachiko Kobayashi; Reiko Kishi
  REPRODUCTIVE TOXICOLOGY, 74, 94, 103, Dec. 2017, [Peer-reviewed]
  English, Scientific journal
• Cord Blood Bisphenol A Levels and Reproductive and Thyroid Hormone Levels of Neonates The Hokkaido Study on Environment and Children's Health
  Machiko Minatoya; Seiko Sasaki; Atsuko Araki; Chihiro Miyashita; Sachiko Itoh; Jun Yamamoto; Toru Matsumura; Takahiko Mitsui; Kimihiko Moriya; Kazutoshi Cho; Keita Morioka; Hisanori Minakami; Nobuo Shinohara; Reiko Kishi
  EPIDEMIOLOGY, 28, S3, S9, Oct. 2017, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Gender-specific association of exposure to non-dioxin-like polychlorinated biphenyls during pregnancy with methylation levels of H19 and long interspersed nuclear element-1 in cord blood in the Hokkaido study
  Sumitaka Kobayashi; Fumihiro Sata; Chihiro Miyashita; Ryu Miura; Kaoru Azumi; Sachiko Kobayashi; Houman Goudarzi; Atsuko Araki; Mayumi Ishizuka; Takashi Todaka; Jumboku Kajiwara; Tsuguhide Hori; Reiko Kishi
  TOXICOLOGY, 390, 135, 145, Sep. 2017, [Peer-reviewed]
  English, Scientific journal
• Association of prenatal exposure to perfluoroalkyl substances with cord blood adipokines and birth size: The Hokkaido Study on environment and children's health
  Machiko Minatoya; Sachiko Itoh; Chihiro Miyashita; Atsuko Araki; Seiko Sasaki; Ryu Miura; Houman Goudarzi; Yusuke Iwasaki; Reiko Kishi
  ENVIRONMENTAL RESEARCH, 156, 175, 182, Jul. 2017, [Peer-reviewed]
  English, Scientific journal
• Prenatal exposure to perfluoroalkyl acids and prevalence of infectious diseases up to 4 years of age
  Houman Goudarzi; Chihiro Miyashita; Emiko Okada; Ikuko Kashino; Chi-Jen Chen; Sachiko Ito; Atsuko Araki; Sumitaka Kobayashi; Hideyuki Matsuura; Reiko Kishi
  ENVIRONMENT INTERNATIONAL, 104, 132, 138, Jul. 2017, [Peer-reviewed]
  English, Scientific journal
• Associated factors of behavioural problems in children at preschool age: the Hokkaido study on environment and children's health
  Minatoya, M.; Itoh, S.; Araki, A.; Tamura, N.; Yamazaki, K.; Nishihara, S.; Miyashita, C.; Kishi, R.
  Child: Care, Health and Development, 43, 3, 385, 392, May 2017, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Effects of prenatal perfluoroalkyl acid exposure on cord blood IGF2/H19 methylation and ponderal index: The Hokkaido Study
  Sachiko Kobayashi; Kaoru Azumi; Houman Goudarzi; Atsuko Araki; Chihiro Miyashita; Sumitaka Kobayashi; Sachiko Itoh; Seiko Sasaki; Mayumi Ishizuka; Hiroyuki Nakazawa; Tamiko Ikeno; Reiko Kishi
  JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY, 27, 3, 251, 259, May 2017, [Peer-reviewed]
  English, Scientific journal
• LEVEL OF PRENATAL ADRENAL STEROIDS HORMONES AFFECTS BODY WEIGHT AT BIRTH
  Takahiko Mitsui; Atsuko Araki; Sachiko Ito; Chihiro Miyashita; Kimihiko Moriya; Takeya Kitta; Kazutoshi Cho; Keita Morioka; Nobuo Shinohara; Masayuki Takeda; Reiko Kishi; Katsuya Nonomura
  JOURNAL OF UROLOGY, 197, 4, E475, E475, Apr. 2017, [Peer-reviewed], [International Magazine]
  English
• 殺虫用途の農薬への曝露とADHDを中心とした神経発達障害との関連についての疫学研究動向
  西原 進吉; 荒木 敦子; 宮下 ちひろ; 山崎 圭子; 岸 玲子
  北海道公衆衛生学雑誌, 30, 2, 27, 40, 北海道公衆衛生学会, Mar. 2017
  Japanese
• Prenatal di(2-ethylhexyl) phthalate exposure and disruption of adrenal androgens and glucocorticoids levels in cord blood: The Hokkaido Study
  Atsuko Araki; Takahiko Mitsui; Houman Goudarzi; Tamie Nakajima; Chihiro Miyashita; Sachiko Itoh; Seiko Sasaki; Kazutoshi Cho; Kimihiko Moriya; Nobuo Shinohara; Katsuya Nonomura; Reiko Kishi
  SCIENCE OF THE TOTAL ENVIRONMENT, 581, 297, 304, Mar. 2017, [Peer-reviewed]
  English, Scientific journal
• 子どもを取り巻く環境と健康(第24回)(最終回) 誰もが健康な人生のスタートを 世界で進む出生コーホート研究
  岸 玲子; 湊屋 街子; 荒木 敦子; 宮下 ちひろ
  公衆衛生, 81, 2, 175, 183, (株)医学書院, Feb. 2017
  Japanese
• Prenatal di-2-ethylhexyl phthalate exposure and cord blood adipokine levels and birth size: The Hokkaido study on environment and children's health
  Machiko Minatoya; Atsuko Araki; Chihiro Miyashita; Seiko Sasaki; Yuko Goto; Tamie Nakajima; Reiko Kishi
  SCIENCE OF THE TOTAL ENVIRONMENT, 579, 606, 611, Feb. 2017, [Peer-reviewed]
  English, Scientific journal
• The Hokkaido Birth Cohort Study on Environment and Children's Health: cohort profile-updated 2017
  Reiko Kishi; Atsuko Araki; Machiko Minatoya; Tomoyuki Hanaoka; Chihiro Miyashita; Sachiko Itoh; Sumitaka Kobayashi; Yu Ait Bamai; Keiko Yamazaki; Ryu Miura; Naomi Tamura; Kumiko Ito; Houman Goudarzi
  ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE, 22, 1, 46, 2017, [Peer-reviewed]
  English, Scientific journal
• The Association of Prenatal Exposure to Perfluorinated Chemicals with Glucocorticoid and Androgenic Hormones in Cord Blood Samples: The Hokkaido Study
  Houman Goudarzi; Atsuko Araki; Sachiko Itoh; Seiko Sasaki; Chihiro Miyashita; Takahiko Mitsui; Hiroyuki Nakazawa; Katsuya Nonomura; Reiko Kishi
  ENVIRONMENTAL HEALTH PERSPECTIVES, 125, 1, 111, 118, Jan. 2017, [Peer-reviewed]
  English, Scientific journal
• Dioxin-metabolizing genes in relation to effects of prenatal dioxin levels and reduced birth size: The Hokkaido study
  Sumitaka Kobayashi; Fumihiro Sata; Chihiro Miyashita; Seiko Sasaki; Susumu Ban; Atsuko Araki; Houman Goudarzi; Jumboku Kajiwara; Takashi Todaka; Reiko Kishi
  REPRODUCTIVE TOXICOLOGY, 67, 111, 116, Jan. 2017, [Peer-reviewed]
  English, Scientific journal
• Quantifying bisphenol A in maternal and cord whole blood using isotope dilution liquid chromatography/tandem mass spectrometry and maternal characteristics associated with bisphenol A
  Jun Yamamoto; Machiko Minatoya; Seiko Sasaki; Atsuko Araki; Chihiro Miyashita; Toru Matsumura; Reiko Kishi
  CHEMOSPHERE, 164, 25, 31, Dec. 2016, [Peer-reviewed]
  English, Scientific journal
• Exposure to phthalates in house dust and associated allergies in children aged 6-12 years
  Yu Ait Bamai; Atsuko Araki; Toshio Kawai; Tazuru Tsuboi; Ikue Saito; Eiji Yoshioka; Shi Cong; Reiko Kishi
  ENVIRONMENT INTERNATIONAL, 96, 16, 23, Nov. 2016, [Peer-reviewed]
  English, Scientific journal
• Combined effects of AHR, CYP1A1, and XRCC1 genotypes and prenatal maternal smoking on infant birth size: Biomarker assessment in the Hokkaido Study
  Sumitaka Kobayashi; Fumihiro Sata; Seiko Sasaki; Titilola Serifat Braimoh; Atsuko Araki; Chihiro Miyashita; Houman Goudarzi; Sachiko Kobayashi; Reiko Kishi
  REPRODUCTIVE TOXICOLOGY, 65, 295, 306, Oct. 2016, [Peer-reviewed]
  English, Scientific journal
• Association of perfluoroalkyl substances exposure in utero with reproductive hormone levels in cord blood in the Hokkaido Study on Environment and Children's Health
  Sachiko Itoh; Atsuko Araki; Takahiko Mitsui; Chihiro Miyashita; Houman Goudarzi; Seiko Sasaki; Kazutoshi Cho; Hiroyuki Nakazawa; Yusuke Iwasaki; Nobuo Shinohara; Katsuya Nonomura; Reiko Kishi
  ENVIRONMENT INTERNATIONAL, 94, 51, 59, Sep. 2016, [Peer-reviewed]
  English, Scientific journal
• Effects of prenatal exposure to perfluoroalkyl acids on prevalence ofallergic diseases among 4-year-old children
  Houman Goudarzi; Chihiro Miyashita; Emiko Okada; Ikuko Kashino; Sumitaka Kobayashi; Chi-Jen Chen; Sachiko Ito; Atsuko Araki; Hideyuki Matsuura; Yoichi M. Ito; Reiko Kishi
  ENVIRONMENT INTERNATIONAL, 94, 124, 132, Sep. 2016, [Peer-reviewed]
  English, Scientific journal
• Effects of prenatal phthalate exposure on thyroid hormone levels, mental and psychomotor development of infants: The Hokkaido Study on Environment and Children's Health
  Machiko Minatoya; Sonomi Naka Jima; Seiko Sasaki; Atsuko Araki; Chihiro Miyashita; Tamiko Ikeno; Tamie Nakajima; Yuko Goto; Reiko Kishi
  SCIENCE OF THE TOTAL ENVIRONMENT, 565, 1037, 1043, Sep. 2016, [Peer-reviewed]
  English, Scientific journal
• Effects of adrenal androgens during the prenatal period on the second to fourth digit ratio in school-aged children
  Takahiko Mitsui; Atsuko Araki; Houman Goudarzi; Chihiro Miyashita; Sachiko Ito; Seiko Sasaki; Takeya Kitta; Kimihiko Moriya; Kazutoshi Cho; Keita Morioka; Reiko Kishi; Nobuo Shinohara; Masayuki Takeda; Katsuya Nonomura
  STEROIDS, 113, 46, 51, Sep. 2016, [Peer-reviewed]
  English, Scientific journal
• 環境省「エコチル調査」開始4年を経ての集計結果の報告 全国と北海道の参加者の喫煙・食物アレルギー等について
  土川 陽子; 西條 泰明; 伊藤 善也; 吉岡 英治; 川西 康之; 堤 裕幸; 遠藤 俊明; 馬場 剛; 小林 正樹; 水上 尚典; 有賀 正; 長 和俊; 白石 秀明; 千石 一雄; 宮本 敏伸; 東 寛; 荒木 敦子; 池野 多美子; 宮下 ちひろ; 伊藤 佐智子; 湊屋 街子; 小林 澄貴; アイツバマイ ゆふ; 山崎 圭子; 西原 進吉; 田村 菜穂美; 岸 玲子
  北海道母性衛生学会誌, 45, 33, 38, 北海道母性衛生学会, Aug. 2016
  Japanese
• 子どもを取り巻く環境と健康(第18回) 葉酸摂取の胎児発育や先天異常,生後アレルギーへの影響
  宮下 ちひろ; 伊藤 久美子; 荒木 敦子; 岸 玲子
  公衆衛生, 80, 8, 615, 621, (株)医学書院, Aug. 2016
  Japanese
• Predictors of folate status among pregnant Japanese women: the Hokkaido Study on Environment and Children's Health, 2002-2012
  Thamar A. Yila; Atsuko Araki; Seiko Sasaki; Chihiro Miyashita; Kumiko Itoh; Tamiko Ikeno; Eiji Yoshioka; Sumitaka Kobayashi; Houman Goudarzi; Toshiaki Baba; Titilola Braimoh; Hisanori Minakami; Toshiaki Endo; Kazuo Sengoku; Reiko Kishi
  BRITISH JOURNAL OF NUTRITION, 115, 12, 2227, 2235, Jun. 2016, [Peer-reviewed]
  English, Scientific journal
• The Association between Prenatal Yoga and the Administration of Ritodrine Hydrochloride during Pregnancy: An Adjunct Study of the Japan Environment and Children's Study
  Yasuyuki Kawanishi; Yasuaki Saijo; Eiji Yoshioka; Yoshihiko Nakagi; Takahiko Yoshida; Toshinobu Miyamoto; Kazuo Sengoku; Yoshiya Ito; Chihiro Miyashita; Atsuko Araki; Reiko Kishi
  PLOS ONE, 11, 6, e0158155, Jun. 2016, [Peer-reviewed]
  English, Scientific journal
• A Birth Cohort Study Focused on Environmental Chemicals : Current Status and Future Perspectives of the Hokkaido Study on Environment and Children's Health
  岸 玲子; 宮下 ちひろ; 荒木 敦子
  Anti-aging medicine, 12, 2, 211, 220, (株)メディカルレビュー社, Apr. 2016
  Japanese, 2001年に「環境と子どもの健康に関する北海道スタディ」を立ち上げるに至った背景と目的、本スタディの特徴について述べた。本スタディは大小2つの前向きコホートから成り、一つは地域ベースの37医療機関における大規模コホートで、母児20929名のペアである。もう一つは札幌の一産科医療機関を受診した妊婦を対象にした小規模コホートで、母児14名のペアである。小規模コホートでは、PCB・ダイオキシン類、有機フッ素化合物(PFAA)等の測定を終了した小児を対象に、PFAA曝露の影響を調査している。大規模ホコートでは、高精度のGC/MS分析を用いてPCDD、PCDF等の同族異性体分析やダイオキシン様PCB濃度を測定し、ダイオキシン類の毒性等価量の算出を行っている。
• 環境化学物質の胎児期曝露による児の神経発達への影響に関する疫学文献レビュー 注意欠如・多動性障害(AD/HD)・自閉症スペクトラム(ASD)を含めて
  小林 澄貴; 池野 多美子; 荒木 敦子; 山崎 圭子; 西原 進吉; 岸 玲子
  北海道公衆衛生学雑誌, 29, 2, 31, 40, 北海道公衆衛生学会, Mar. 2016
  Japanese, 有機フッ素化合物を加えた合計68種類について、これらの物質曝露における児の注意欠如・多動性障害(AD/HD)や自閉症スペクトラム(ASD)関連症状を含めた神経発達への影響の疫学的知見をまとめ、今後の研究課題について検討した。胎児期の母親の環境化学物質曝露による神経発達に及ぼす影響に関する先行研究のレビューから、有機塩素系農薬、有機リン系農薬、PCB・ダイオキシン類・臭素系難燃剤、有機フッ素化合物、BPAおよびフタル酸エステル類では濃度によっては生後の神経発達に負の影響を及ぼすことが明らかになった。また、農薬ではその代謝関連のPON1とGSTP1遺伝子多型により生後の児の神経発達の遅れに差が出ること、物質によっては母親の遺伝的感受性によってその遅れに差が認められる可能性が示唆された。遺伝的にリスクが高い集団がいることを配慮した上で、妊婦が可能な限り胎児期の環境化学物質曝露を回避できる環境整備が重要と思われた。
• 子どもを取り巻く環境と健康(第13回) 環境化学物質曝露による内分泌系への影響 性ホルモン
  荒木 敦子; 伊藤 佐智子; 岸 玲子
  公衆衛生, 80, 3, 221, 227, (株)医学書院, Mar. 2016
  Japanese
• Prenatal exposure to perfluorinated chemicals and neurodevelopment in early infancy: The Hokkaido Study
  Houman Goudarzi; Sonomi Nakajima; Tamiko Ikeno; Seiko Sasaki; Sachiko Kobayashi; Chihiro Miyashita; Sachiko Ito; Atsuko Araki; Hiroyuki Nakazawa; Reiko Kishi
  SCIENCE OF THE TOTAL ENVIRONMENT, 541, 1002, 1010, Jan. 2016, [Peer-reviewed]
  English, Scientific journal
• The Relationship between the Second-to-Fourth Digit Ratio and Behavioral Sexual Dimorphism in School-Aged Children
  Takahiko Mitsui; Atsuko Araki; Chihiro Miyashita; Sachiko Ito; Tamiko Ikeno; Seiko Sasaki; Takeya Kitta; Kimihiko Moriya; Kazutoshi Cho; Keita Morioka; Reiko Kishi; Nobuo Shinohara; Masayuki Takeda; Katsuya Nonomura
  PLOS ONE, 11, 1, e0146849, Jan. 2016, [Peer-reviewed]
  English, Scientific journal
• 子どもを取り巻く環境と健康(第10回) 乳幼児のアレルギーと胎児期・小児期の可塑剤・難燃剤曝露
  荒木 敦子; アイツバマイ ゆふ; 岸 玲子
  公衆衛生, 79, 12, 876, 881, (株)医学書院, Dec. 2015
  Japanese
• Effects of in utero exposure to polychlorinated biphenyls, methylmercury, and polyunsaturated fatty acids on birth size
  Chihiro Miyashita; Seiko Sasaki; Tamiko Ikeno; Atsuko Araki; Sachiko Ito; Jumboku Kajiwara; Takashi Todaka; Noriyuki Hachiya; Akira Yasutake; Katsuyuki Murata; Tamie Nakajima; Reiko Kishi
  SCIENCE OF THE TOTAL ENVIRONMENT, 533, 256, 265, Nov. 2015, [Peer-reviewed]
  English, Scientific journal
• The Association of Prenatal Exposure to Perfluorinated Chemicals with Maternal Essential and Long-Chain Polyunsaturated Fatty Acids during Pregnancy and the Birth Weight of Their Offspring: The Hokkaido Study
  Reiko Kishi; Tamie Nakajima; Houman Goudarzi; Sachiko Kobayashi; Seiko Sasaki; Emiko Okada; Chihiro Miyashita; Sachiko Itoh; Atsuko Araki; Tamiko Ikeno; Yusuke Iwasaki; Hiroyuki Nakazawa
  ENVIRONMENTAL HEALTH PERSPECTIVES, 123, 10, 1038, 1045, Oct. 2015, [Peer-reviewed]
  English, Scientific journal
• Association of maternal whole blood fatty acid status during the prenatal period with term birth dimensions: a cross-sectional study
  Xiaofang Jia; Masahiro Tagawa; Hiroshi Yatsuya; Hisao Naito; Yumi Hayashi; Husna Yetti; Seiko Sasaki; Atsuko Araki; Chihiro Miyashita; Tamiko Ikeno; Reiko Kishi; Tamie Nakajima
  JOURNAL OF PERINATAL MEDICINE, 43, 5, 565, 575, Sep. 2015, [Peer-reviewed]
  English, Scientific journal
• 環境省「エコチル調査」開始3年を経ての集計データの報告と調査予定
  土川 陽子; 西條 泰明; 伊藤 善也; 吉岡 英治; 川西 康之; 堤 裕幸; 遠藤 俊明; 馬場 剛; 小林 正樹; 水上 尚典; 有賀 正; 長 和俊; 白石 秀明; 千石 一雄; 宮本 敏伸; 東 寛; 荒木 敦子; 池野 多美子; 宮下 ちひろ; 伊藤 佐智子; 岸 玲子
  北海道母性衛生学会誌, 44, 25, 30, 北海道母性衛生学会, Aug. 2015
  Japanese
• 子どもを取り巻く環境と健康(第5回) 環境化学物質の曝露 短半減期化学物質の曝露実態
  荒木 敦子; アイツバマイ ゆふ; 岸 玲子
  公衆衛生, 79, 7, 485, 490, (株)医学書院, Jul. 2015
  Japanese
• Comparisons of urinary phthalate metabolites and daily phthalate intakes among Japanese families
  Yu Ait Bamai; Atsuko Araki; Toshio Kawai; Tazuru Tsuboi; Eiji Yoshioka; Ayako Kanazawa; Shi Cong; Reiko Kishi
  INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH, 218, 5, 461, 470, Jul. 2015, [Peer-reviewed]
  English, Scientific journal
• Prenatal maternal blood triglyceride and fatty acid levels in relation to exposure to di(2-ethylhexyl)phthalate: a cross-sectional study
  Xiaofang Jia; Yukiko Harada; Masahiro Tagawa; Hisao Naito; Yumi Hayashi; Husna Yetti; Masashi Kato; Seiko Sasaki; Atsuko Araki; Chihiro Miyashita; Tamiko Ikeno; Reiko Kishi; Tamie Nakajima
  ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE, 20, 3, 168, 178, May 2015, [Peer-reviewed]
  English, Scientific journal
• Maternal passive smoking and infant birth weight Literature review
  小林 澄貴; 荒木 敦子; 佐々木 成子; 池野 多美子; 宮下 ちひろ; 伊藤 佐智子; 岸 玲子
  北海道公衆衛生学雑誌, 28, 2, 37, 48, 北海道公衆衛生学会, Mar. 2015
  Japanese, 妊娠中の受動喫煙が児の出生体重に及ぼす影響について文献検討をした。検索開始年は絞らず、2014年12月迄に発表された論文について、「Secondhand smoke」「Passive smoking」あるいは「Environmental tobacco smoke」と「Birth weigth」をキーワードとしてand条件としてPubMedで文献検索を行った。内容を精査したうえで、最終的に37編を分析対象とした。36編の論文で質問票が用いられており、バイオマーカーとして血清などを測定した論文は2編のみであった。受動喫煙の評価には、自宅や職場に喫煙者がいる・いないでおこなっているもの、喫煙者の人数でおこなっているものなどさまざまであった。14編が前向きコーホート研究、7編が後ろ向きコーホート研究、11編が横断研究、5編が症例対照研究であった。暴露時期別に評価している論文から、妊娠初期の後半以降(妊娠12週以降)に受動喫煙にさらされると出生体重の減少、低出生体重や早産のリスクの上昇といった報告が多かった。
• Effects of Prenatal Leydig Cell Function on the Ratio of the Second to Fourth Digit Lengths in School-Aged Children
  Takahiko Mitsui; Atsuko Araki; Ayako Imai; Sakiko Sato; Chihiro Miyashita; Sachiko Ito; Seiko Sasaki; Takeya Kitta; Kimihiko Moriya; Kazutoshi Cho; Keita Morioka; Reiko Kishi; Katsuya Nonomura
  PLOS ONE, 10, 3, e0120636, Mar. 2015, [Peer-reviewed]
  English, Scientific journal
• Association between Maternal Exposure to di(2-ethylhexyl) Phthalate and Reproductive Hormone Levels in Fetal Blood: The Hokkaido Study on Environment and Children's Health
  Atsuko Araki; Takahiko Mitsui; Chihiro Miyashita; Tamie Nakajima; Hisao Naito; Sachiko Ito; Seiko Sasaki; Kazutoshi Cho; Tamiko Ikeno; Katsuya Nonomura; Reiko Kishi
  PLOS ONE, 9, 10, e109039, Oct. 2014, [Peer-reviewed]
  English, Scientific journal
• Phthalates and organophosphate triesters in house dust and their health effects on inhabitants
  荒木 敦子; アイツバマイ ゆふ; 岸 玲子
  空気清浄, 52, 3, 170, 177, (公社)日本空気清浄協会, Sep. 2014
  Japanese
• 専門医のためのアレルギー学講座 環境因子とアレルギー 環境汚染とアレルギーに関する疫学的知見 特に室内空気質に焦点をあてて
  荒木 敦子; アイツバマイ ゆふ; 岸 玲子
  アレルギー, 63, 8, 1075, 1083, (一社)日本アレルギー学会, Sep. 2014
  Japanese
• 環境省「エコチル調査」開始2年の報告と今後の調査について
  土川 陽子; 西條 泰明; 伊藤 善也; 吉岡 英治; 川西 康之; 堤 裕幸; 遠藤 俊明; 馬場 剛; 小林 正樹; 水上 尚典; 有賀 正; 野々村 克也; 長 和俊; 白石 秀明; 千石 一雄; 宮本 敏伸; 東 寛; 池野 多美子; 荒木 敦子; 宮下 ちひろ; 伊藤 佐智子; 岸 玲子
  北海道母性衛生学会誌, 43, 37, 42, 北海道母性衛生学会, Aug. 2014
  Japanese
• Exposure to house dust phthalates in relation to asthma and allergies in both children and adults
  Yu Ait Bamai; Eiji Shibata; Ikue Saito; Atsuko Araki; Ayako Kanazawa; Kanehisa Morimoto; Kunio Nakayama; Masatoshi Tanaka; Tomoko Takigawa; Takesumi Yoshimura; Hisao Chikara; Yasuaki Saijo; Reiko Kishi
  SCIENCE OF THE TOTAL ENVIRONMENT, 485, 153, 163, Jul. 2014, [Peer-reviewed]
  English, Scientific journal
• Association of Mechanical Ventilation and Flue Use in Heaters With Asthma Symptoms in Japanese Schoolchildren: A Cross-Sectional Study in Sapporo, Japan
  Shi Cong; Atsuko Araki; Shigekazu Ukawa; Yu Ait Bamai; Shuji Tajima; Ayako Kanazawa; Motoyuki Yuasa; Akiko Tamakoshi; Reiko Kishi
  JOURNAL OF EPIDEMIOLOGY, 24, 3, 230, 238, May 2014, [Peer-reviewed]
  English, Scientific journal
• Detection and intake assessment of organophosphate flame retardants in house dust in Japanese dwellings
  Shuji Tajima; Atsuko Araki; Toshio Kawai; Tazuru Tsuboi; Yu Ait Bamai; Eiji Yoshioka; Ayako Kanazawa; Shi Cong; Reiko Kishi
  SCIENCE OF THE TOTAL ENVIRONMENT, 478, 190, 199, Apr. 2014, [Peer-reviewed]
  English, Scientific journal
• 北海道3地区における妊婦の喫煙の実態について 環境省「子どもの環境と健康に関する全国調査(エコチル調査)」北海道ユニットセンター登録者のデータから
  荒木 敦子; 西條 泰明; 伊藤 善也; 池野 多美子; 宮下 ちひろ; 伊藤 佐智子; 土川 陽子; 田村 菜穂美; 吉岡 英治; 川西 康之; 村林 宏; 岸 玲子; エコチル調査北海道ユニットセンター事務局
  北海道公衆衛生学雑誌, 27, 2, 105, 113, 北海道公衆衛生学会, Mar. 2014
  Japanese, 環境省「エコチル調査」北海道ユニットセンター登録妊婦3901名のデータを基に、妊婦の喫煙の実態について報告した。その結果、喫煙経験者は1941名で、うち妊娠中も喫煙を継続している(喫煙継続)群は5.4%、妊娠中に禁煙した(妊娠中禁煙)群は15.1%、妊娠前から禁煙していた(妊娠前禁煙)群は30.0%であった。喫煙継続群は、妊娠中禁煙群、妊娠前禁煙群と比べ、喫煙開始年齢が早く、収入および学歴が低かった。また、喫煙継続群ではパートナーが喫煙している割合が83.0%と有意に多く、受動喫煙の機会・頻度も多いことが判明した。
• アジア出生コホートコンソーシアム(Birth Cohort Consortium of Asia:BiCCA)の設立と現在の取り組みについて
  岸 玲子; 荒木 敦子
  北海道公衆衛生学雑誌, 27, 2, 191, 195, 北海道公衆衛生学会, Mar. 2014
  Japanese
• Phosphorus flame retardants in indoor dust and their relation to asthma and allergies of inhabitants
  A. Araki; I. Saito; A. Kanazawa; K. Morimoto; K. Nakayama; E. Shibata; M. Tanaka; T. Takigawa; T. Yoshimura; H. Chikara; Y. Saijo; R. Kishi
  Indoor Air, 24, 1, 3, 15, Feb. 2014, [Peer-reviewed]
  English, Scientific journal
• Associations of phthalate concentrations in floor dust and multi-surface dust with the interior materials in Japanese dwellings
  Yu Ait Bamai; Atsuko Araki; Toshio Kawai; Tazuru Tsuboi; Ikue Saito; Eiji Yoshioka; Ayako Kanazawa; Shuji Tajima; Cong Shi; Akiko Tamakoshi; Reiko Kishi
  SCIENCE OF THE TOTAL ENVIRONMENT, 468, 147, 157, Jan. 2014, [Peer-reviewed]
  English, Scientific journal
• Epidemiological studies on the environmental pollutants and allergies: Focused on in-door air quality
  Atsuko Araki; Yu Ait Bamai; Reiko Kishi
  Japanese Journal of Allergology, 63, 8, 1075, 1084, Japanese Society of Allergology, 2014, [Peer-reviewed]
  Japanese, Scientific journal
• Ten years of progress in the Hokkaido birth cohort study on environment and children's health: cohort profile-updated 2013
  Reiko Kishi; Sachiko Kobayashi; Tamiko Ikeno; Atsuko Araki; Chihiro Miyashita; Sachiko Itoh; Seiko Sasaki; Emiko Okada; Sumitaka Kobayashi; Ikuko Kashino; Kumiko Itoh; Sonomi Nakajima
  ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE, 18, 6, 429, 450, Nov. 2013, [Peer-reviewed]
  English
• The relationship between atopic dermatitis and indoor environmental factors: a cross-sectional study among Japanese elementary school children
  Shigekazu Ukawa; Atsuko Araki; Ayako Kanazawa; Motoyuki Yuasa; Reiko Kishi
  INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH, 86, 7, 777, 787, Oct. 2013, [Peer-reviewed]
  English, Scientific journal
• Multiple chemical sensitivity/Idiopathic environmental intolerance : its scientific knowledge and the feasibility study of aromatherapy massage to reduce its symptoms
  荒木 敦子; 岸 玲子
  Aroma Research, 14, 2, 111, 115, フレグランスジャーナル社, May 2013
  Japanese
• 北海道における環境省「エコチル調査」に関する意識調査と広報活動の課題
  荒木 敦子; 尾西 奈江; 中瀬 督久; 伊藤 善也; 西條 泰明; 池野 多美子; 安住 薫; 土川 陽子; 宮下 ちひろ; 伊藤 佐智子; 岸 玲子; エコチル調査北海道ユニットセンター事務局
  北海道公衆衛生学雑誌, 26, 2, 125, 132, 北海道公衆衛生学会, Mar. 2013
  Japanese, エコチル調査は、子どもの健康に与える環境要因を解明することを目的とし、「胎児期から小児期にかけての化学物質曝露が子どもの健康に大きな影響を与えている」ことを中心仮説としており、全国10万組の親子を対象とした出生コホート調査である。北海道では、札幌、旭川、北見の3地区で調査を進めている。今回、エコチル調査がメディアに露出する前後の道民の認知度・意識を明らかにし、今後の課題について示唆を得る目的で検討を行った。方法は、北海道新聞情報研究所が管理運営する「Doshinインターネット」のモニターを対象とし、エコチル調査の広報を集中的に行った前後の平成24年3月と4月の2回WEBアンケートを実施した。回答者数は1回目が678名、2回目が675名であり、エコチル調査の認知度は1回目14.4%であったが2回目には30.9%に上昇していた。これは、新聞をはじめとしたマスメディアによるPR広告の効果と思われた。今後、エコチル調査への関心を持続させるための課題として、調査の進捗状況など得られた成果を開示していくことが必要と考えられた。
• The feasibility of aromatherapy massage to reduce symptoms of Idiopathic Environmental Intolerance: A pilot study
  Atsuko Araki; Kazuhiko Watanabe; Yoko Eitaki; Toshio Kawai; Reiko Kishi
  COMPLEMENTARY THERAPIES IN MEDICINE, 20, 6, 400, 408, Dec. 2012, [Peer-reviewed]
  English, Scientific journal
• A randomized controlled trial of a Functioning Improvement Tool home-visit program and its effect on cognitive function in older persons
  Shigekazu Ukawa; Hiroki Satoh; Motoyuki Yuasa; Tamiko Ikeno; Tomoko Kawabata; Atsuko Araki; Eiji Yoshioka; Waka Murata; Katsunori Ikoma; Reiko Kishi
  INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 27, 6, 557, 564, Jun. 2012, [Peer-reviewed]
  English, Scientific journal
• The relationship between exposure to microbial volatile organic compound and allergy prevalence in single-family homes
  Atsuko Araki; Ayako Kanazawa; Toshio Kawai; Yoko Eitaki; Kanehisa Morimoto; Kunio Nakayama; Eiji Shibata; Masatoshi Tanaka; Tomoko Takigawa; Takesumi Yoshimura; Hisao Chikara; Yasuaki Saijo; Reiko Kishi
  SCIENCE OF THE TOTAL ENVIRONMENT, 423, 18, 26, Apr. 2012, [Peer-reviewed]
  English, Scientific journal
• Validation of diffusive mini-samplers for aldehyde and VOC and its feasibility for measuring the exposure levels of elementary school children
  Atsuko Araki; Tazuru Tsuboi; Toshio Kawai; Yu Ait Bamai; Tomoya Takeda; Eiji Yoshioka; Reiko Kishi
  JOURNAL OF ENVIRONMENTAL MONITORING, 14, 2, 368, 374, Feb. 2012, [Peer-reviewed]
  English, Scientific journal
• Relationships between mite allergen levels, mold concentrations, and sick building syndrome symptoms in newly built dwellings in Japan
  Y. Saijo; A. Kanazawa; A. Araki; K. Morimoto; K. Nakayama; T. Takigawa; M. Tanaka; E. Shibata; T. Yoshimura; H. Chikara; R. Kishi
  INDOOR AIR, 21, 3, 253, 263, Jun. 2011, [Peer-reviewed]
  English, Scientific journal
• [Variations of indoor environment and the prevalence of sick house syndrome over three-year period in detached houses in Sapporo].
  Araki A; Kanazawa A; Saijo Y; Kishi R
  Nihon eiseigaku zasshi. Japanese journal of hygiene, 66, 3, 589, 599, 3, May 2011, [Peer-reviewed], [Domestic magazines]
  Japanese, Scientific journal, OBJECTIVES: The purpose of this study was to investigate annual variations in indoor environmental chemical, fungal and dust mite allergen levels, with regards to variations in sick house syndrome (SHS) symptoms over a three-year period. METHODS: Detached houses were randomly selected from a building plan approval application, and a questionnaire survey was conducted in 2003 in Sapporo, Japan. Indoor environmental measurements and a self-administered questionnaires survey were conducted on the selected houses in 2004, 2005 and 2006. The same protocol was used for the three-year period to measure the levels of chemicals, fungi and dust mite allergens. A personal questionnaire to assess SHS was distributed to all inhabitants of the dwellings along with one questionnaire to assess housing characteristics. RESULTS: In 2004, 2005 and 2006, the owners of 104, 64 and 41 houses, respectively, agreed to participate in this study. Forty-one houses and the 127 inhabitants who participated in this three-year survey period were included in the analysis to evaluate the associations between differences in environmental measurements and SHS. The levels of formaldehyde, acetone, toluene, Alternaria and Cladosporium tended to decrease, whereas those of limonene and Aspergillus tended to increase over the three-year period. Increasing levels of Cryptococcus and the dampness index in individual houses correlated with increasing SHS symptom scores in the inhabitants after mutual adjustment. CONCLUSIONS: Although the average levels of chemicals and fungi were relatively low, the results show the relationship between annual variations in indoor environmental measurements and variations in SHS symptom scores.
• Building-related symptoms among the elementally school pupils and their association to organic phosphate triesters exposure at home in Sapporo
  Takeda Tomoya; Araki Atsuko; AitBamai Yu; Saito Ikue; Hayakawa Atsushi; Yoshioka Eiji; Kanazawa Ayako; Yuasa Motoyuki; Kishi Reiko
  Hokkaido Journal of Public Health, 24, 2, 73, 84, 北海道公衆衛生学会, Mar. 2011
  Japanese, 札幌市の公立小学校に通う児童78名を対象に、自宅居間の床ダスト中における有機リン酸トリエステル類11化合物の測定を行い、シックハウス症候群(SHS)との関連について検討した。SHS有訴群(39名)と非有訴群(39名)とで11化合物の濃度を比較したところ、全ての化合物において有意な群間差は認められなかった。しかし、化合物のうちリン酸トリスブトキシエチルの濃度は、過去に欧米で報告された濃度に比べてかなり高かったことから、健康影響について更なる調査が必要であると考えられた。
• シックハウス症候群研究の最新情報 シックハウス症候群に関する全国疫学研究(その全体像と何がわかったか)
  岸 玲子; 荒木 敦子
  日本衛生学雑誌, 66, 2, 277, 278, 日本衛生学会, Feb. 2011
  Japanese
• Prevalence of Asthma, Atopic Dermatitis, and Rhinitis and MVOC Exposure in Single Family Homes-A Survey in 6 Cities of Japan
  Atsuko Araki; Toshio Kawai; Yoko Eitaki; Ayako Kanazawa; Kanehisa Morimoto; Kunio Nakayama; Eiji Shibata; Masatoshi Tanaka; Tomoko Takigawa; Takesumi Yoshimura; Hisao Chikara; Yasuaki Saijo; Reiko Kishi
  EPIDEMIOLOGY, 22, 1, S40, S41, Jan. 2011, [Peer-reviewed]
  English
• Relationship between selected indoor volatile organic compounds, so-called microbial VOC, and the prevalence of mucous membrane symptoms in single family homes
  Atsuko Araki; Toshio Kawai; Yoko Eitaki; Ayako Kanazawa; Kanehisa Morimoto; Kunio Nakayama; Eiji Shibata; Masatoshi Tanaka; Tomoko Takigawa; Takesumi Yoshimura; Hisao Chikara; Yasuaki Saijo; Reiko Kishi
  SCIENCE OF THE TOTAL ENVIRONMENT, 408, 10, 2208, 2215, Apr. 2010, [Peer-reviewed]
  English, Scientific journal
• 【環境リスク】 シックハウス症候群に関する研究の現状と今後の課題
  岸 玲子; 荒木 敦子
  公衆衛生, 74, 4, 295, 299, (株)医学書院, Apr. 2010
  Japanese
• Association between indoor exposure to semi-volatile organic compounds and building-related symptoms among the occupants of residential dwellings
  A. Kanazawa; I. Saito; A. Araki; M. Takeda; M. Ma; Y. Saijo; R. Kishi
  INDOOR AIR, 20, 1, 72, 84, Feb. 2010, [Peer-reviewed]
  English, Scientific journal
• Diffusive sampling and measurement of microbial volatile organic compounds in indoor air
  A. Araki; Y. Eitaki; T. Kawai; A. Kanazawa; M. Takeda; R. Kishi
  INDOOR AIR, 19, 5, 421, 432, Oct. 2009, [Peer-reviewed]
  English, Scientific journal
• Relationship between sick building syndrome and indoor environmental factors in newly built Japanese dwellings
  Makoto Takeda; Yasuaki Saijo; Motoyuki Yuasa; Ayako Kanazawa; Atsuko Araki; Reiko Kishi
  INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH, 82, 5, 583, 593, Apr. 2009, [Peer-reviewed]
  English, Scientific journal
• 基礎医学から シックハウス症候群の疫学 最近の知見
  岸 玲子; 竹田 誠; 金澤 文子; 荒木 敦子
  日本医事新報, 4370, 73, 76, (株)日本医事新報社, Jan. 2008
  Japanese
• Cloning and expression of a gene encoding N-glycosyltrasferase (ngt) from Saccharothrix aerocolonigenes ATCC39243
  T Ohuchi; A Ikeda-Araki; A Watanabe-Sakamoto; K Kojiri; M Nagashima; M Okanishi; H SUda
  JOURNAL OF ANTIBIOTICS, 53, 4, 393, 403, Apr. 2000, [Peer-reviewed]
  English, Scientific journal
• SECRETORY PRODUCTION OF CHICKEN OVOMUCOID DOMAIN-3 BY ESCHERICHIA-COLI AND ALTERATION OF INHIBITORY SPECIFICITY TOWARD PROTEASES BY SUBSTITUTION OF THE P1 SITE RESIDUE
  S KOJIMA; N FUSHIMI; A IKEDA; KUMAGAI, I; K MIURA
  GENE, 143, 2, 239, 243, Jun. 1994, [Peer-reviewed]
  English, Scientific journal

• ハウスダストによる有機フッ素化合物の経口曝露推計:北海道スタディ
  藤谷倫子; 原田浩二; アイツバマイ ゆふ; 山口健史; 曾怡; ケテマ ラヒルメスフィン; ケテマ ラヒルメスフィン; 岸玲子; 池田敦子; 池田敦子, 日本衛生学雑誌(Web), 79, Supplement, 2024
• Effects of prenatal exposure to HFPO-DA on the phenotype and hepatic gene expression profiles in neonatal mice
  村瀬渉; 窪田篤人; 安田彩夏; 箱田涼; 池田敦子; 池田敦子; 小島弘幸; 小島弘幸, 環境化学討論会要旨集(CD-ROM), 32nd, 2024
• Comparative study on gene expression profiles in liver of neonatal mice prenatally exposed by PFOA or its alternate, GenX.
  村瀬渉; 窪田篤人; 箱田涼; 安田彩夏; 池田敦子; 池田敦子; 小島弘幸; 小島弘幸, 日本薬学会年会要旨集(Web), 144th, 154048, 154048, 2024, [International Magazine]
  Hexafluoropropylene oxide dimer acid (HFPO-DA), which belongs to the class of perfluoroalkyl ether carboxylic acid (PFECA), is a new alternative to perfluorooctanoic acid (PFOA). However, whether HFPO-DA is a safer alternative to PFOA in neonates remains unclear. In this study, we evaluated neonatal hepatic toxicity on postnatal days 9-10 by orally exposing pregnant CD-1 mice to 0.3 or 3.0 mg/kg/day (low or high doses) of HFPO-DA or PFOA from gestation days 15-17. The results showed that exposure of pregnant mice to HFPO-DA and PFOA induced similar phenotypic effects, including significant decreases in neonatal body weight (BW) and significant increases in liver weight relative to BW in the high-dose. Notably, HFPO-DA exposure significantly decreased in neonatal BW in the low-dose group, whereas PFOA did not. Comprehensive gene expression analysis revealed significant alterations in 408 and 1402 differentially expressed genes (DEGs) in the liver of neonates from the low- and high-dose HFPO-DA groups, respectively, while PFOA significantly altered 0 and 292 DEGs in the corresponding groups. Gene set enrichment analysis indicated that the DEGs induced by HFPO-DA and PFOA were enriched in pathway related to "PPAR signaling", "fatty acid metabolism", and "biological oxidations". In addition, transactivation assays revealed that mouse (m)PPARα and mPPARγ activity of HFPO-DA exceeds that of PFOA and molecular docking simulations analysis predicted that the binding conformation differ between PFOA and HFPO-DA. Overall, our findings demonstrate that HFPO-DA consistently affected neonatal phenotypes, liver gene expression and the molecular initiating events involving PPARα/γ, at lower concentrations than PFOA., English
• 化粧品使用による有機フッ素化合物の暴露推計
  藤谷倫子; 原田浩二; 増田秀幸; 山口健史; アイツバマイ ゆふ; 池田敦子; 池田敦子, 日本衛生学雑誌(Web), 78, Supplement, 2023
• Numerical Estimation of Wi-Fi Frequency Band Receiving Characteristics for Portable Exposimeter for Epidemiological Research on High-Frequency Exposure and Child Health
  敦賀桜; 杉村海渡; 日景隆; 山崎圭子; 宮下ちひろ; 田村菜穂美; 荒木敦子; 岸玲子, 電気・情報関係学会北海道支部連合大会講演論文集(CD-ROM), 2023, 2023
• Gene expression profiles in human HepaRG liver cells treated with perfluorooctanoic acid (PFOA).
  村瀬渉; 窪田篤人; 木村ゆり; 池田敦子; 池田敦子; 小島弘幸, 日本薬学会年会要旨集(Web), 143rd, 2023
• Effects of di-(2-ethyl hexyl)phthalate metabolites on transcriptional activity via human nuclear receptors and gene expression in HepaRG cells
  安田彩夏; 村瀬渉; 窪田篤人; 浦丸直人; 奥田勝博; 箱田涼; 池田敦子; 池田敦子; 小島弘幸, 衛生薬学・環境トキシコロジー講演要旨集, 2023, 2023
• 子どものスクリーンタイムと聴覚・視覚ワーキングメモリーとの関連:北海道スタディ
  田村菜穂美; 山崎圭子; 宮下ちひろ; 池田敦子; 池田敦子; 日景隆; 水田正弘; 大宮学; 竹鼻美月; 赤坂梨莉花; 岸玲子, 日本衛生学雑誌(Web), 78, Supplement, 2023
• 学童期の子どもの電磁波曝露実態の変化-北海道スタディ
  山崎圭子; 宮下ちひろ; 田村菜穂美; 池田敦子; 池田敦子; 日景隆; 水田正弘; 大宮学; 岸玲子, 日本衛生学雑誌(Web), 78, Supplement, 2023
• Characteristics of Human Body Shadowing Considering Elevation Angle in 5G Frequency Band for Epidemiological Research on RF Exposure and Children’s Health
  敦賀桜; 杉村海渡; 日景隆; 大宮学; 山崎圭子; 宮下ちひろ; 田村奈穂美; 池田敦子; 岸玲子, 電子情報通信学会技術研究報告(Web), 123, 72(EMCJ2023 12-28), 2023
• Editor’s Focus: Maternal Alcohol Use and Fetal Growth in Japan
  Kazutoshi Cho; Sumitaka Kobayashi; Atsuko Araki; Chihiro Miyashita; Sachiko Itoh; Yasuaki Saijo; Yoshiya Ito; Kazuo Sengoku; Tsuyoshi Baba; Hisanori Minakami; Yuichi Nakamura; Reiko Kishi; The Japan Environment and Children’s Study Group, Pediatric Research, 92, 1, 1, 1, Jul. 2022, [Invited], [International Magazine]
  掲載論文（責任著者）が、Pediatric Research volume 92 No. 1 July 2022のEditor’s Focusに選出され紹介された。掲載論文：Kazutoshi Cho, Sumitaka Kobayashi, et al. Prenatal alcohol exposure and adverse fetal growth restriction: findings from the Japan Environment and Children's Study. Pediatric Research. 2022; 92: 291-298. https://doi.org/10.1038/s41390-021-01595-3., Springer Science and Business Media LLC, English, Introduction scientific journal
• 胎児期フタル酸エステル類曝露による思春期発来への影響 北海道スタディ
  山口健史; 山口健史; 池田敦子; 池田敦子; アイツバマイ ゆふ; アイツバマイ ゆふ; 宮下ちひろ; 池中良徳; 池中良徳; 中村明枝; 今雅史; 藤谷倫子; 原田浩二; 岸玲子, DOHad研究(Web), 10, 2, 2022
• Estimation of Human Body Blockage Effects on Portable Exposure Meter for Epidemiological Studies on Radio Wave Exposure and Health Effects in Adolescents
  山本康平; 日景隆; 大宮学; 山崎圭子; 池田敦子; 宮下ちひろ; 田村菜穂美; 岸玲子, 電子情報通信学会大会講演論文集(CD-ROM), 2022, 2022
• Estimation of Human Body Blockage Characteristics Considering Elevation Angle of Plane-wave for RF Dosimetry of Adolescent
  杉村海渡; 山本康平; 日景隆; 山崎恵子; 宮下ちひろ; 田村菜穂美; 荒木敦子; 岸玲子, 電気・情報関係学会北海道支部連合大会講演論文集(CD-ROM), 2022, 2022
• 小児の携帯情報端末の使用開始年齢と問題行動の程度との関連-北海道スタディ
  宮下ちひろ; 山崎圭子; 田村菜穂美; 池田敦子; 池田敦子; 福永久典; 日景隆; 水田正弘; 大宮学; 岸玲子, 日本衛生学雑誌(Web), 77, Supplement, 2022
• 学童期における携帯電話等の電磁波曝露の実態調査-北海道スタディ
  山崎圭子; 田村菜穂美; 宮下ちひろ; 池田敦子; 池田敦子; 福永久典; 日景隆; 水田正弘; 大宮学; 岸玲子, 日本衛生学雑誌(Web), 77, Supplement, 2022
• 子どものスクリーンタイムおよび問題行動との関連:北海道スタディ
  田村菜穂美; 山崎圭子; 宮下ちひろ; 池田敦子; 池田敦子; 福永久典; 日景隆; 水田正弘; 大宮学; 岸玲子, 日本衛生学雑誌(Web), 77, Supplement, 2022
• Characterization of Human Body Blockage in Cellular and Wireless LAN Frequency Bands for Epidemiologic Research on Association Between Radio Frequency Wave Exposure and Children Health
  山本康平; 杉村海渡; 日景隆; 大宮学; 山崎圭子; 宮下ちひろ; 田村奈穂美; 池田敦子; 岸玲子, 電子情報通信学会技術研究報告(Web), 122, 40(EMCJ2022 8-13), 2022
• Estimation on Human Body Blockage Characteristics of Child Model for Epidemiologic Research on RF Exposure and Adolescent Health
  杉村海渡; 山本康平; 日景隆; 大宮学; 山崎圭子; 宮下ちひろ; 田村奈穂美; 池田敦子; 岸玲子, 電子情報通信学会技術研究報告(Web), 122, 67(EMCJ2022 14-27), 2022
• 室内空気中SVOC(準揮発性有機化合物)濃度の実態調査
  金 勲; 稲葉 洋平; 戸次 加奈江; 東 賢一; 林 基哉; 荒木 敦子; アイツバマイ ゆふ; 篠原 直秀; 欅田 尚樹, 室内環境学会学術大会講演要旨集, 2021年, 104, 105, Dec. 2021
  (一社)室内環境学会, Japanese
• 一般家庭における短期/長期堆積ダストを活用したSVOCの曝露評価研究1 リン系難燃剤・可塑剤の室内濃度分布と汚染要因の解析
  戸次 加奈江; 池田 敦子; アイツバマイ ゆふ; 稲葉 洋平; 東 賢一; 金 勲; 岸 玲子, 室内環境学会学術大会講演要旨集, 2021年, 100, 101, Dec. 2021
  (一社)室内環境学会, Japanese
• 一般家庭における短期/長期堆積ダストを活用したSVOCの曝露評価研究2 子どものハウスダスト中リン系難燃剤・可塑剤の一日摂取量
  池田 敦子; 戸次 加奈江; アイツバマイ ゆふ; 稲葉 洋平; 金 勲; 岸 玲子, 室内環境学会学術大会講演要旨集, 2021年, 102, 103, Dec. 2021
  (一社)室内環境学会, Japanese
• 許容濃度等の勧告(2021年度)
  野見山 哲生; 圓藤 吟史; 圓藤 陽子; 河合 俊夫; 岸 玲子; 田中 茂; 長野 嘉介; 那須 民江; 矢野 栄二; 東 賢一; 石竹 達也; 市場 正良; 市原 学; 伊藤 昭好; 岩澤 聡子; 大前 和幸; 奥田 裕計; 加藤 貴彦; 上島 通浩; 苅田 香苗; 川本 俊弘; 日下 幸則; 熊谷 信二; 祖父江 友孝; 竹下 達也; 武林 亨; 原 邦夫; 福島 哲仁; 保利 一; 堀江 正知; 宮内 博幸; 宮川 宗之; 森本 泰夫; 山野 優子; 横山 和仁; 伊藤 由起; 上山 純; 梅田 ゆみ; 佐藤 一博; 諏訪園 靖; 竹内 靖人; 竹内 文乃; 塚原 照臣; 辻 真弓; 内藤 久雄; 中野 真規子; 松本 明子; 山内 武紀; 荒木 敦子; 上野 晋; 奥田 昌之; 各務 竹康; 原田 浩二; 堀口 兵剛; 山本 健也; 日本産業衛生学会許容濃度等に関する委員会(2020年度), 産業衛生学雑誌, 63, 5, 179, 211, Sep. 2021
  (公社)日本産業衛生学会, Japanese
• 北海道における毒性学研究 胎児期の環境化学物質曝露による出生時の性ホルモンかく乱作用 環境と子どもの健康に関する北海道スタディ
  荒木 敦子; 岸 玲子, 環境ホルモン学会研究発表会要旨集, 23回, 5, 5, Sep. 2021
  環境ホルモン学会(日本内分泌撹乱化学物質学会), Japanese
• 【COVID-19が流行しない社会を目指す-社会医学・環境衛生学の視点から】環境健康科学の立場からその研究と教育の現状と課題
  荒木 敦子; 宮下 ちひろ; 岸 玲子; 小笠原 克彦, 公衆衛生, 85, 6, 400, 407, Jun. 2021
  (株)医学書院, Japanese
• 妊婦の血中フタル酸エステル類と脂肪酸濃度 遺伝環境交互作用の影響 北海道スタディ
  小林 澄貴; 佐田 文宏; 荒木 敦子; 宮下 ちひろ; グウダルジ・ホウマヌ; 那須 民江, 日本衛生学雑誌, 76, Suppl., S155, S155, Mar. 2021
  (一社)日本衛生学会, Japanese
• 小児期の肥満傾向と喘鳴リスクの関連:北海道スタディ
  宮下 ちひろ; 小林 澄貴; 荒木 敦子; 伊藤 佐智子; アイツバマイ・ユフ; 山崎 圭子; 岸 玲子, 日本衛生学雑誌, 76, Suppl., S189, S189, Mar. 2021
  (一社)日本衛生学会, Japanese
• 北海道のハウスダスト中のフタル酸エステル類及びその代替物質の分析
  稲葉 洋平; 戸次 加奈江; アイツバマイ・ユフ; 荒木 敦子; 岸 玲子, 日本衛生学雑誌, 76, Suppl., S201, S201, Mar. 2021
  (一社)日本衛生学会, Japanese
• 電波へのばく露による児の精神神経発達への影響に関する最近の研究動向 文献調査
  山崎 圭子; 荒木 敦子; 田村 菜穂美; 寺岡 友里; 日景 隆; 水田 正弘; 大宮 学; 岸 玲子, 北海道公衆衛生学雑誌, 34, 2, 14, 21, Mar. 2021
  北海道公衆衛生学会, Japanese
• 妊婦の血中フタル酸エステル類と脂肪酸濃度 遺伝環境交互作用の影響 北海道スタディ
  小林 澄貴; 佐田 文宏; 荒木 敦子; 宮下 ちひろ; グウダルジ・ホウマヌ; 那須 民江, 日本衛生学雑誌, 76, Suppl., S155, S155, Mar. 2021
  (一社)日本衛生学会, Japanese
• 小児期の肥満傾向と喘鳴リスクの関連:北海道スタディ
  宮下 ちひろ; 小林 澄貴; 荒木 敦子; 伊藤 佐智子; アイツバマイ・ユフ; 山崎 圭子; 岸 玲子, 日本衛生学雑誌, 76, Suppl., S189, S189, Mar. 2021
  (一社)日本衛生学会, Japanese
• 北海道のハウスダスト中のフタル酸エステル類及びその代替物質の分析
  稲葉 洋平; 戸次 加奈江; アイツバマイ・ユフ; 荒木 敦子; 岸 玲子, 日本衛生学雑誌, 76, Suppl., S201, S201, Mar. 2021
  (一社)日本衛生学会, Japanese
• Estimation on Human Body Blockage Characteristics at Wireless LAN Frequency Bands for Epidemiologic Research on RF Exposure and Adolescent Health
  山本康平; 尾崎龍之介; 日景隆; 山本学; 荒木敦子; 宮下ちひろ; 田村奈穂美; 山崎恵子; 岸玲子, 電気・情報関係学会北海道支部連合大会講演論文集(CD-ROM), 2021, 2021
• 【子どもと環境-胎児期・幼少期の環境が与える影響】わが国で最初の出生コホート"環境と子どもの健康に関する北海道スタディ" ライフコースアプローチに基づく成果を中心に
  岸 玲子; 荒木 敦子; 宮下 ちひろ, 医学のあゆみ, 275, 9, 967, 972, Nov. 2020
  医歯薬出版(株), Japanese
• 許容濃度等の勧告(2020年度)
  野見山 哲生; 池田 正之; 圓藤 吟史; 圓藤 陽子; 大前 和幸; 河合 俊夫; 岸 玲子; 小泉 昭夫; 櫻井 治彦; 佐藤 洋; 田中 茂; 田中 正敏; 長野 嘉介; 那須 民江; 矢野 栄二; 市場 正良; 市原 学; 奥田 裕計; 加藤 貴彦; 上島 通浩; 苅田 香苗; 川本 俊弘; 日下 幸則; 熊谷 信二; 祖父江 友孝; 竹下 達也; 武林 亨; 原 邦夫; 福島 哲仁; 保利 一; 宮川 宗之; 森本 泰夫; 山野 優子; 横山 和仁; 東 賢一; 伊藤 由起; 岩澤 聡子; 上野 晋; 上山 純; 梅田 ゆみ; 佐藤 一博; 諏訪園 靖; 竹内 靖人; 塚原 照臣; 角田 正史; 内藤 久雄; 中野 真規子; 原田 浩二; 堀口 兵剛; 松本 明子; 村田 勝敬; 山内 武紀; 石竹 達也; 伊藤 昭好; 竹内 文乃; 堀江 正知; 宮内 博幸; 荒木 敦子; 奥田 昌之; 各務 竹康; 山本 健也; 日本産業衛生学会許容濃度等に関する委員会(2019年度), 産業衛生学雑誌, 62, 5, 198, 230, Sep. 2020
  (公社)日本産業衛生学会, Japanese
• 胎児期有機フッ素化合物曝露と脂肪酸濃度 遺伝子との相互作用の影響-北海道スタディ
  小林 澄貴; 佐田 文宏; ホウマヌ・グウダルジ; 荒木 敦子; 宮下 ちひろ; 佐々木 成子; 岡田 恵美子; 岩崎 雄介; 那須 民江; 岸 玲子, 日本衛生学雑誌, 75, Suppl., S159, S159, Mar. 2020
  (一社)日本衛生学会, Japanese
• 電波および携帯電話への胎児期曝露による児の健康影響に関する最近の研究動向 文献調査
  荒木 敦子; 山崎 圭子; 寺岡 友里; 日景 隆; 水田 正弘; 大宮 学; 岸 玲子, 日本衛生学雑誌, 75, Suppl., S172, S172, Mar. 2020
  (一社)日本衛生学会, Japanese
• 環境と子どもの健康に関する北海道研究(北海道スタディ)からの小児気管支喘息リスクスコア作成
  西條 泰明; 佐藤 遊洋; 吉岡 英治; 小林 澄貴; 宮下 ちひろ; 湊屋 街子; 荒木 敦子; 岸 玲子, 日本衛生学雑誌, 75, Suppl., S199, S199, Mar. 2020
  (一社)日本衛生学会, Japanese
• 電波曝露と学童期の行動の問題及び認知機能との関連に関する最近の研究動向 文献調査
  山崎 圭子; 荒木 敦子; 寺岡 友里; 日景 隆; 水田 正弘; 大宮 学; 岸 玲子, 日本衛生学雑誌, 75, Suppl., S199, S199, Mar. 2020
  (一社)日本衛生学会, Japanese
• 胎児期有機フッ素化合物曝露と脂肪酸濃度 遺伝子との相互作用の影響-北海道スタディ
  小林 澄貴; 佐田 文宏; ホウマヌ・グウダルジ; 荒木 敦子; 宮下 ちひろ; 佐々木 成子; 岡田 恵美子; 岩崎 雄介; 那須 民江; 岸 玲子, 日本衛生学雑誌, 75, Suppl., S159, S159, Mar. 2020
  (一社)日本衛生学会, Japanese
• 電波および携帯電話への胎児期曝露による児の健康影響に関する最近の研究動向 文献調査
  荒木 敦子; 山崎 圭子; 寺岡 友里; 日景 隆; 水田 正弘; 大宮 学; 岸 玲子, 日本衛生学雑誌, 75, Suppl., S172, S172, Mar. 2020
  (一社)日本衛生学会, Japanese
• 環境と子どもの健康に関する北海道研究(北海道スタディ)からの小児気管支喘息リスクスコア作成
  西條 泰明; 佐藤 遊洋; 吉岡 英治; 小林 澄貴; 宮下 ちひろ; 湊屋 街子; 荒木 敦子; 岸 玲子, 日本衛生学雑誌, 75, Suppl., S199, S199, Mar. 2020
  (一社)日本衛生学会, Japanese
• 電波曝露と学童期の行動の問題及び認知機能との関連に関する最近の研究動向 文献調査
  山崎 圭子; 荒木 敦子; 寺岡 友里; 日景 隆; 水田 正弘; 大宮 学; 岸 玲子, 日本衛生学雑誌, 75, Suppl., S199, S199, Mar. 2020
  (一社)日本衛生学会, Japanese
• 学童期の肥満に関連する要因の検討 北海道スタディ
  湊屋 街子; 宮下 ちひろ; 三浦 りゅう; 荒木 敦子; 岸 玲子, 北海道公衆衛生学雑誌, 33, 1特別付録, 41, 41, Nov. 2019
  北海道公衆衛生学会, Japanese
• 「環境化学物質と健康障害の予防」に関するWHO CC(研究協力センター)の取り組みとWHOによる子どもの環境と健康研修モジュールの紹介
  荒木 敦子; 湊屋 街子; 岸 玲子, 北海道公衆衛生学雑誌, 33, 1特別付録, 50, 50, Nov. 2019
  北海道公衆衛生学会, Japanese
• 許容濃度等の勧告(2019年度)
  武林 亨; 池田 正之; 圓藤 陽子; 圓藤 吟史; 大前 和幸; 河合 俊夫; 岸 玲子; 小泉 昭夫; 櫻井 治彦; 佐藤 洋; 田中 茂; 田中 正敏; 長野 嘉介; 那須 民江; 矢野 栄二; 市場 正良; 市原 学; 奥田 裕計; 加藤 貴彦; 上島 通浩; 苅田 香苗; 川本 俊弘; 日下 幸則; 熊谷 信二; 祖父江 友孝; 竹下 達也; 野見山 哲生; 原 邦夫; 福島 哲仁; 保利 一; 宮川 宗之; 森本 泰夫; 山野 優子; 横山 和仁; 東 賢一; 伊藤 由起; 岩澤 聡子; 上野 晋; 上山 純; 梅田 ゆみ; 佐藤 一博; 諏訪園 靖; 竹内 靖人; 塚原 照臣; 角田 正史; 内藤 久雄; 中野 真規子; 原田 浩二; 堀口 兵剛; 松本 明子; 村田 勝敬; 山内 武紀; 石竹 達也; 伊藤 昭好; 竹内 文乃; 堀江 正知; 宮内 博幸; 荒木 敦子; 奥田 昌之; 各務 竹康; 山本 健也; 日本産業衛生学会許容濃度等に関する委員会(2018年度), 産業衛生学雑誌, 61, 5, 170, 202, Sep. 2019
  (公社)日本産業衛生学会, Japanese
• WHO研究協力センターとしての環境化学物質と健康障害の予防に関する取り組み
  荒木敦子; 湊屋街子; 岸玲子, 産業衛生学雑誌, 61, 臨増, 588, 588, 22 May 2019
  (公社)日本産業衛生学会, Japanese
• 小児における排尿習慣の確立と脳の性分化
  守屋 仁彦; 西村 陽子; 中村 美智子; 今 雅史; 橘田 岳也; 荒木 敦子; 宮下 ちひろ; 伊藤 佐智子; 長 和俊; 三井 貴彦; 村井 祥代; 岸 玲子; 篠原 信雄, 日本泌尿器科学会総会, 107回, OP, 071, Apr. 2019
  (一社)日本泌尿器科学会総会事務局, Japanese
• アジアにおける有機フッ素化合物の胎児期曝露が及ぼす児の健康影響
  伊藤佐智子; 荒木敦子; 宮下ちひろ; 岸玲子, 北海道公衆衛生学雑誌, 32, 2, 43‐54, 54, 31 Mar. 2019
  北海道公衆衛生学会, Japanese
• アジアにおける有機フッ素化合物の胎児期曝露が及ぼす児の健康影響
  伊藤 佐智子; 荒木 敦子; 宮下 ちひろ; 岸 玲子, 北海道公衆衛生学雑誌, 32, 2, 43, 54, Mar. 2019
  北海道公衆衛生学会, Japanese
• 学童の尿中リン酸トリエステル類代謝物濃度と尿中炎症関連マーカーとの関連
  アイツバマイ ゆふ; Bastiaensen Michiel; 荒木 敦子; Houman Goudarzi; 今野 哲; 伊藤 佐智子; 宮下 ちひろ; Covaci Adrian; 岸 玲子, 日本衛生学雑誌, 74, Suppl., S116, S116, Feb. 2019
  (一社)日本衛生学会, Japanese
• 胎児期の環境化学物質への混合曝露による児の性ホルモンへの影響
  荒木 敦子; 宮下 ちひろ; 伊藤 佐智子; 三井 貴彦; ホウマヌ・ゴウダルジ; 長 和俊; 守屋 仁彦; 那須 民江; 岩崎 雄介; 堀 就英; 梶原 淳睦; 篠原 信雄; 岸 玲子, 日本衛生学雑誌, 74, Suppl., S122, S122, Feb. 2019
  (一社)日本衛生学会, Japanese
• 胎児期の有機塩素系農薬曝露と3.5歳の児の問題行動の関連 北海道スタディ
  山崎 圭子; 荒木 敦子; 中島 そのみ; 宮下 ちひろ; 池野 多美子; 伊藤 佐智子; 湊屋 街子; 水谷 太; 苣木 洋一; 岸 玲子, 日本衛生学雑誌, 74, Suppl., S123, S123, Feb. 2019
  (一社)日本衛生学会, Japanese
• 胎児期の喫煙曝露と学童期の子どもの体格 北海道スタディ
  湊屋 街子; 宮下 ちひろ; 荒木 敦子; 岸 玲子, 日本衛生学雑誌, 74, Suppl., S141, S141, Feb. 2019
  (一社)日本衛生学会, Japanese
• 環境と子どもの健康に関する北海道研究(北海道スタディ)からの小児肥満リスクスコア作成
  西條 泰明; 伊藤 善也; 佐藤 遊洋; 吉岡 英治; 宮下 ちひろ; 湊屋 街子; 荒木 敦子; 岸 玲子, 日本衛生学雑誌, 74, Suppl., S157, S157, Feb. 2019
  (一社)日本衛生学会, Japanese
• 学童の尿中リン酸トリエステル類代謝物濃度と尿中炎症関連マーカーとの関連
  アイツバマイ ゆふ; Bastiaensen Michiel; 荒木 敦子; Houman Goudarzi; 今野 哲; 伊藤 佐智子; 宮下 ちひろ; Covaci Adrian; 岸 玲子, 日本衛生学雑誌, 74, Suppl., S116, S116, Feb. 2019
  (一社)日本衛生学会, Japanese
• 胎児期の環境化学物質への混合曝露による児の性ホルモンへの影響
  荒木 敦子; 宮下 ちひろ; 伊藤 佐智子; 三井 貴彦; ホウマヌ・ゴウダルジ; 長 和俊; 守屋 仁彦; 那須 民江; 岩崎 雄介; 堀 就英; 梶原 淳睦; 篠原 信雄; 岸 玲子, 日本衛生学雑誌, 74, Suppl., S122, S122, Feb. 2019
  (一社)日本衛生学会, Japanese
• 胎児期の有機塩素系農薬曝露と3.5歳の児の問題行動の関連 北海道スタディ
  山崎 圭子; 荒木 敦子; 中島 そのみ; 宮下 ちひろ; 池野 多美子; 伊藤 佐智子; 湊屋 街子; 水谷 太; 苣木 洋一; 岸 玲子, 日本衛生学雑誌, 74, Suppl., S123, S123, Feb. 2019
  (一社)日本衛生学会, Japanese
• 胎児期の喫煙曝露と学童期の子どもの体格 北海道スタディ
  湊屋 街子; 宮下 ちひろ; 荒木 敦子; 岸 玲子, 日本衛生学雑誌, 74, Suppl., S141, S141, Feb. 2019
  (一社)日本衛生学会, Japanese
• 環境と子どもの健康に関する北海道研究(北海道スタディ)からの小児肥満リスクスコア作成
  西條 泰明; 伊藤 善也; 佐藤 遊洋; 吉岡 英治; 宮下 ちひろ; 湊屋 街子; 荒木 敦子; 岸 玲子, 日本衛生学雑誌, 74, Suppl., S157, S157, Feb. 2019
  (一社)日本衛生学会, Japanese
• 胎児期有機フッ素化合物濃度と出生体重との関連:異物代謝酵素遺伝型の修飾による影響―北海道スタディ
  小林澄貴; 佐田文宏; 佐田文宏; 荒木敦子; 宮下ちひろ; 佐々木成子; 坂晋; 岩崎雄介; 岸玲子, 日本疫学会学術総会講演集(Web), 29th, 133 (WEB ONLY), 30 Jan. 2019
  Japanese
• 学術研究からの少子化対策 日本衛生学会からの提言に向けて 日本衛生学会における少子化対策提言に向けて 日本衛生学会少子化対策ワーキンググループによるとりまとめ
  野村 恭子; 苅田 香苗; 荒木 敦子; 西岡 笑子; 武藤 剛; 岩井 美幸; 錦谷 まりこ; 井上 まり子; 鶴ヶ野 しのぶ; 北野 尚美; 辻 真弓; 飯島 佐知子; 上田 佳代; 上島 通浩; 山縣 然太郎; 坂田 清美; 伊木 雅之; 柳澤 裕之; 加藤 昌志; 横山 和仁; 小泉 昭夫; 大槻 剛巳, 日本衛生学雑誌, 74, 1of5, 5of5, 2019
  日本衛生学会では、少子化対策ワーキンググループを設置し、少子化対策シンポジウムを開催し、この問題について様々な角度から議論を重ねてきた。主にそのシンポジウムにおける学術的知見を次の様にまとめた。1)未婚化、晩婚化に対する社会環境整備、2)労働衛生領域における環境整備、3)職場の少子化対策、4)環境化学物質による性成熟、生殖能力への影響、5)社会環境および親のストレスと小児の健全な育ちに関する包括的な研究、として述べた。, (一社)日本衛生学会, Japanese
• 胎児期の受動喫煙曝露が正期産のSmall-for-gestational-age（SGA）に及ぼす影響：前向き出生コーホート研究（北海道スタディ）
  小林澄貴; 佐田文宏; 花岡知之; チチローラ・ブライモー; 伊藤久美子; 田村菜穂美; 荒木敦子; 伊藤佐智子; 宮下ちひろ; 岸玲子, 北海道公衆衛生学雑誌, 33, 2, 10, 12, 2019, [Invited], [Domestic magazines]
  妊娠後期の受動喫煙曝露が正期産のSmall-for-gestational-age(SGA)に及ぼす影響について検討した。北海道内40産科病院で調査協力を依頼し同意が得られた妊婦20788名を対象に、前向き出生コホート研究を実施した。妊娠8ヵ月時に母体血漿を採取し、高感度酵素免疫測定法を用いてコチニン値を測定、SGAは日本小児科学会の在胎期間別出生時体格基準値に従って判定した。ROC曲線下面積は0.554〜0.557を示し、母体血漿コチニンのカットオフ値は3.03ng/mLであった。コチニン値<3.03ng/mLの妊婦と比較して、コチニン値≧3.03ng/mLの妊婦が正期産のSGA児を産むオッズ比は2.44倍高かった。また、能動および受動喫煙曝露されていない妊婦と比較して、受動喫煙のみ曝露された妊婦が正期産のSGA児を産むオッズ比は2.28倍高かった。妊娠後期における妊婦の受動喫煙曝露であっても、能動喫煙曝露と同様に正期産のSGA児を産むリスクがあることが明らかになった。, 北海道公衆衛生学会, Japanese, Introduction scientific journal
• 小児における排尿習慣の確立と脳の性分化
  守屋仁彦; 西村陽子; 西村陽子; 中村美智子; 今雅史; 橘田岳也; 荒木敦子; 宮下ちひろ; 伊藤佐智子; 長和俊; 三井貴彦; 村井祥代; 岸玲子; 篠原信雄, 日本泌尿器科学会総会(Web), 107th, ROMBUNNO.OP‐071 (WEB ONLY), 071, 2019
  (一社)日本泌尿器科学会総会事務局, Japanese
• 学術研究からの少子化対策 日本衛生学会からの提言に向けて 日本衛生学会における少子化対策提言に向けて 日本衛生学会少子化対策ワーキンググループによるとりまとめ
  野村 恭子; 苅田 香苗; 荒木 敦子; 西岡 笑子; 武藤 剛; 岩井 美幸; 錦谷 まりこ; 井上 まり子; 鶴ヶ野 しのぶ; 北野 尚美; 辻 真弓; 飯島 佐知子; 上田 佳代; 上島 通浩; 山縣 然太郎; 坂田 清美; 伊木 雅之; 柳澤 裕之; 加藤 昌志; 横山 和仁; 小泉 昭夫; 大槻 剛巳, 日本衛生学雑誌, 74, 1of5, 5of5, 2019
  日本衛生学会では、少子化対策ワーキンググループを設置し、少子化対策シンポジウムを開催し、この問題について様々な角度から議論を重ねてきた。主にそのシンポジウムにおける学術的知見を次の様にまとめた。1)未婚化、晩婚化に対する社会環境整備、2)労働衛生領域における環境整備、3)職場の少子化対策、4)環境化学物質による性成熟、生殖能力への影響、5)社会環境および親のストレスと小児の健全な育ちに関する包括的な研究、として述べた。, (一社)日本衛生学会, Japanese
• エコチル調査北海道ユニットセンターの進捗状況と,2歳までの喘鳴および湿疹の有病割合に関する報告
  荒木敦子; 西條泰明; 伊藤善也; AIT BAMAI Yu; 宮下ちひろ; 伊藤佐智子; 小林澄貴; 湊屋街子; 山崎圭子; 三浦りゅう; 吉岡英治; 川西康之; 村林宏; 佐藤遊洋; 岸玲子, 日本内分泌かく乱化学物質学会研究発表会要旨集, 21st, 100, 100, Dec. 2018
  環境ホルモン学会(日本内分泌撹乱化学物質学会), Japanese
• エコチル調査北海道ユニットセンターの進捗状況と、2歳までの喘鳴および湿疹の有病割合に関する報告
  荒木 敦子; 西條 泰明; 伊藤 善也; アイツバマイ ゆふ; 宮下 ちひろ; 伊藤 佐智子; 小林 澄貴; 湊屋 街子; 山崎 圭子; 三浦 りゅう; 吉岡 英治; 川西 康之; 村林 宏; 佐藤 遊洋; 岸 玲子, 環境ホルモン学会研究発表会要旨集, 21回, 100, 100, Dec. 2018
  環境ホルモン学会(日本内分泌撹乱化学物質学会), Japanese
• エコチル調査北海道ユニットセンターの進捗状況と、2歳までの喘鳴および湿疹の有病割合に関する報告
  荒木 敦子; 西條 泰明; 伊藤 善也; アイツバマイ ゆふ; 宮下 ちひろ; 伊藤 佐智子; 小林 澄貴; 湊屋 街子; 山崎 圭子; 三浦 りゅう; 吉岡 英治; 川西 康之; 村林 宏; 佐藤 遊洋; 岸 玲子, 環境ホルモン学会研究発表会要旨集, 21回, 100, 100, Dec. 2018
  環境ホルモン学会(日本内分泌撹乱化学物質学会), Japanese
• 室内ダスト中リン酸トリエステル類とその尿中代謝物濃度と学童の喘鳴・アレルギー症状との関連 札幌市学童調査
  荒木 敦子; アイツバマイ ゆふ; Bastiaensen Michiel; Van den Eede Nele; 河合 俊夫; 坪井 樹; Ketema Rahel Mesfin; Covaci Adrian; 岸 玲子, 北海道公衆衛生学雑誌, 32, 1特別付録, 66, 66, Oct. 2018
  北海道公衆衛生学会, Japanese
• 許容濃度等の勧告(2018年度)
  武林 亨; 池田 正之; 圓藤 陽子; 圓藤 吟史; 大前 和幸; 河合 俊夫; 岸 玲子; 小泉 昭夫; 櫻井 治彦; 佐藤 洋; 田中 茂; 田中 正敏; 長野 嘉介; 那須 民江; 矢野 栄二; 市場 正良; 市原 学; 奥田 裕計; 加藤 貴彦; 上島 通浩; 苅田 香苗; 川本 俊弘; 日下 幸則; 熊谷 信二; 祖父江 友孝; 竹下 達也; 野見山 哲生; 原 邦夫; 福島 哲仁; 保利 一; 宮川 宗之; 森本 泰夫; 山野 優子; 横山 和仁; 東 賢一; 伊藤 由起; 岩澤 聡子; 上野 晋; 上山 純; 梅田 ゆみ; 佐藤 一博; 諏訪園 靖; 竹内 靖人; 塚原 照臣; 角田 正史; 内藤 久雄; 中野 真規子; 原田 浩二; 堀口 兵剛; 松本 明子; 村田 勝敬; 山内 武紀; 石竹 達也; 伊藤 昭好; 竹内 文乃; 堀江 正知; 宮内 博幸; 荒木 敦子; 奥田 昌之; 各務 竹康; 山本 健也; 日本産業衛生学会許容濃度等に関す, 産業衛生学雑誌, 60, 5, 116, 148, Sep. 2018
  (公社)日本産業衛生学会, Japanese
• 学術研究からの少子化対策-日本衛生学会からの提言に向けて 環境化学物質による次世代の性ホルモンへの影響
  荒木 敦子; 伊藤 佐智子; 宮下 ちひろ; 湊屋 街子; 岸 玲子, 日本衛生学雑誌, 73, 3, 313, 321, Sep. 2018
  環境化学物質による内分泌撹乱作用により、体内のホルモン濃度は撹乱されると考えられる。また、環境化学物質により、女性では、第二次性徴、生理不順、妊孕性の低下、不妊、子宮内膜症等の疾患に、男性では精子の質の低下や不妊への影響が示唆されている。環境化学物質による次世代の性腺への影響について、以下の項目に分けて概説した。1)「環境と子供の健康に関する北海道スタディ」の紹介、2)環境化学物質曝露と児の性ホルモンへの影響、3)代替物質と複合曝露、について述べた。, (一社)日本衛生学会, Japanese
• ヒトマクロファージ様THP‐1細胞の遺伝子発現に及ぼす核内受容体アゴニストの曝露影響
  小島弘幸; 武内伸治; 室本竜太; 岸玲子; 荒木敦子, 日本免疫毒性学会学術年会講演要旨集, 25th, 98, Aug. 2018
  Japanese
• Environmental chemicals and their effects on children based on the first birth cohort studies in Japan
  岸玲子; 荒木敦子, 保健医療科学, 67, 3, 292‐305, Aug. 2018
  Japanese
• 【これまでの環境リスクとこれからの環境リスク】 わが国で初めての本格的な出生コーホート研究から見た環境化学物質の濃度レベルと次世代影響
  岸 玲子; 荒木 敦子, 保健医療科学, 67, 3, 292, 305, Aug. 2018
  国立保健医療科学院, Japanese
• 小型携帯サンプラーを用いた学童の化学物質曝露と自宅環境中濃度との関連
  荒木敦子; 河合俊夫; 坪井樹; アイツバマイ ゆふ; 岸玲子, 産業衛生学雑誌, 60, 臨増, 416, 416, 16 May 2018
  (公社)日本産業衛生学会, Japanese
• 【住環境における健康リスク要因とそのマネジメント】 室内環境中のハウスダストによる健康影響
  荒木 敦子; アイツバマイ ゆふ; ラヘル・メスフィン・ケテマ; 岸 玲子, 日本衛生学雑誌, 73, 2, 130, 137, May 2018
  2003年より室内環境と居住者の健康に関する疫学研究を実施し、ダスト中のダニアレルゲン、微生物由来成分、準揮発性有機化合物を測定してきた。これら疫学研究の結果から、特にハウスダストに焦点を当て、健康影響としてシックハウス症候群やアレルギー症状との関連について概説した。最後に、ダストを用いた曝露評価の課題について述べた。, (一社)日本衛生学会, Japanese
• 【小児環境保健疫学研究のパラダイム】 2万人規模の出生コーホートと、500人規模の小コーホートからなる北海道スタディが目指してきたもの 環境と子どもの健康 先天異常・発達・アレルギーの15年におよぶ経験と成果
  岸 玲子; 荒木 敦子; 宮下 ちひろ; 伊藤 佐智子; 湊屋 街子; 小林 澄貴; 山崎 圭子; アイツバマイ ゆふ; 三浦 りゅう; 田村 菜穂美, 日本衛生学雑誌, 73, 2, 164, 177, May 2018
  2001年より胎児期からの環境曝露影響を前向きに研究する「環境と子供の健康に関する北海道スタディー」を立ち上げた。これは2万人規模と500人規模の大小2つの前向きコーホートから構成されている。1)北海道スタディーの背景と目的、特徴、2)追跡の時系列デザインと測定項目、3)北海道スタディーでこれまでに得られた成果、4)北海道スタディーの今後の課題と提言、について概説した。, (一社)日本衛生学会, Japanese
• 【住環境における健康リスク要因とそのマネジメント】 科学的エビデンスに基づく『新シックハウス症候群に関する相談と対策マニュアル(改訂新版)』を作成して
  岸 玲子; 吉野 博; 荒木 敦子; 西條 泰明; 東 賢一; 河合 俊夫; 大和 浩; 大澤 元毅; 柴田 英治; 田中 正敏; 増地 あゆみ; 湊屋 街子; アイツバマイ ゆふ, 日本衛生学雑誌, 73, 2, 116, 129, May 2018
  科学的エビデンスに基づく「新シックハウス症候群に関する相談と対策マニュアル(改訂新版)」を作成したので紹介した。このマニュアルでは、近年震災や豪雨等の災害に伴って入居者が増えている仮設住宅の問題や、地球温暖化による熱中症と室内環境などの最近の問題、電磁過敏症に関する系統的レビューについて記載した。また、快適で健康な建物を実現する上で必要な基礎的な理論、設計の考え方と方法、建物の使い方、設備の調整の方法や扱い方についても解説した。, (一社)日本衛生学会, Japanese
• 【住環境における健康リスク要因とそのマネジメント】 室内環境中のハウスダストによる健康影響
  荒木 敦子; アイツバマイ ゆふ; ラヘル・メスフィン・ケテマ; 岸 玲子, 日本衛生学雑誌, 73, 2, 130, 137, May 2018
  2003年より室内環境と居住者の健康に関する疫学研究を実施し、ダスト中のダニアレルゲン、微生物由来成分、準揮発性有機化合物を測定してきた。これら疫学研究の結果から、特にハウスダストに焦点を当て、健康影響としてシックハウス症候群やアレルギー症状との関連について概説した。最後に、ダストを用いた曝露評価の課題について述べた。, (一社)日本衛生学会, Japanese
• 【小児環境保健疫学研究のパラダイム】 2万人規模の出生コーホートと、500人規模の小コーホートからなる北海道スタディが目指してきたもの 環境と子どもの健康 先天異常・発達・アレルギーの15年におよぶ経験と成果
  岸 玲子; 荒木 敦子; 宮下 ちひろ; 伊藤 佐智子; 湊屋 街子; 小林 澄貴; 山崎 圭子; アイツバマイ ゆふ; 三浦 りゅう; 田村 菜穂美, 日本衛生学雑誌, 73, 2, 164, 177, May 2018
  2001年より胎児期からの環境曝露影響を前向きに研究する「環境と子供の健康に関する北海道スタディー」を立ち上げた。これは2万人規模と500人規模の大小2つの前向きコーホートから構成されている。1)北海道スタディーの背景と目的、特徴、2)追跡の時系列デザインと測定項目、3)北海道スタディーでこれまでに得られた成果、4)北海道スタディーの今後の課題と提言、について概説した。, (一社)日本衛生学会, Japanese
• 胎児期の有機フッ素化合物曝露が7歳のアレルギーに及ぼす影響 北海道スタディ
  アイツバマイ ゆふ; 荒木 敦子; 宮下 ちひろ; 岡田 恵美子; 樫野 郁子; グウダルジ・ホウマヌ; 松浦 英幸; 岸 玲子, 日本衛生学雑誌, 73, Suppl., S225, S225, Mar. 2018
  (一社)日本衛生学会, Japanese
• 尿中リン酸とトリエステル類と児の喘息・アレルギーとの関連 札幌市学童調査
  荒木 敦子; アイツバマイ ゆふ; バスチャンセン・ミキエル; ファンデンイーデ・ネール; ケテマ・ラヘル; 伊藤 佐智子; 宮下 ちひろ; コバチ・アドリアン; 岸 玲子, 日本衛生学雑誌, 73, Suppl., S234, S234, Mar. 2018
  (一社)日本衛生学会, Japanese
• 胎児期の有機塩素系農薬曝露が3.5歳の児の知的機能に及ぼす影響 北海道スタディ
  山崎 圭子; 荒木 敦子; 中島 そのみ; 宮下 ちひろ; 池野 多美子; 伊藤 佐智子; 湊屋 街子; 水谷 太; 苣木 洋一; 岸 玲子, 日本衛生学雑誌, 73, Suppl., S235, S235, Mar. 2018
  (一社)日本衛生学会, Japanese
• 胎児期の両親の喫煙と幼児期におけるADHD症状の関連
  湊屋 街子; 伊藤 佐智子; 小林 澄貴; 山崎 圭子; 宮下 ちひろ; 荒木 敦子; 岸 玲子, 日本衛生学雑誌, 73, Suppl., S243, S243, Mar. 2018
  (一社)日本衛生学会, Japanese
• 胎児期のPCB類曝露による児のH19・LINE-1のDNAメチル化への影響 北海道スタディ
  小林 澄貴; 佐田 文宏; 宮下 ちひろ; 三浦 りゅう; ゴウダルジ・ホウマヌ; 荒木 敦子; 梶原 淳睦; 堀 就英; 岸 玲子, 日本衛生学雑誌, 73, Suppl., S243, S243, Mar. 2018
  (一社)日本衛生学会, Japanese
• 両親の教育歴と児のSmall for gestational ageとの媒介要因分析 北海道スタディ
  田村 菜穂美; 花岡 知之; 伊藤 久美子; 伊藤 佐智子; 宮下 ちひろ; 荒木 敦子; 小笠原 克彦; 岸 玲子, 日本衛生学雑誌, 73, Suppl., S244, S244, Mar. 2018
  (一社)日本衛生学会, Japanese
• 両親の教育歴と児のSmall for gestational ageとの媒介要因分析:北海道スタディ
  田村菜穂美; 田村菜穂美; 花岡知之; 伊藤久美子; 伊藤久美子; 伊藤佐智子; 宮下ちひろ; 荒木敦子; 小笠原克彦; 小笠原克彦; 岸玲子, 日本衛生学雑誌(Web), 73, Supplement, S244, Mar. 2018
  Japanese
• 尿中リン酸トリエステル類と児の喘息・アレルギーとの関連―札幌市学童調査
  荒木敦子; アイツバマイ ゆふ; バスチャンセン ミキエル; ファンデンイーデ ネール; ケテマ ラヘル; ケテマ ラヘル; 伊藤佐智子; 宮下ちひろ; コバチ アドリアン; 岸玲子, 日本衛生学雑誌(Web), 73, Supplement, S234, Mar. 2018
  Japanese
• 胎児期の有機フッ素化合物曝露が7歳のアレルギーに及ぼす影響 北海道スタディ
  アイツバマイ ゆふ; 荒木 敦子; 宮下 ちひろ; 岡田 恵美子; 樫野 郁子; グウダルジ・ホウマヌ; 松浦 英幸; 岸 玲子, 日本衛生学雑誌, 73, Suppl., S225, S225, Mar. 2018
  (一社)日本衛生学会, Japanese
• 尿中リン酸トリエステル類と児の喘息・アレルギーとの関連 札幌市学童調査
  荒木 敦子; アイツバマイ ゆふ; バスチャンセン・ミキエル; ファンデンイーデ・ネール; ケテマ・ラヘル; 伊藤 佐智子; 宮下 ちひろ; コバチ・アドリアン; 岸 玲子, 日本衛生学雑誌, 73, Suppl., S234, S234, Mar. 2018
  (一社)日本衛生学会, Japanese
• 胎児期の有機塩素系農薬曝露が3.5歳の児の知的機能に及ぼす影響 北海道スタディ
  山崎 圭子; 荒木 敦子; 中島 そのみ; 宮下 ちひろ; 池野 多美子; 伊藤 佐智子; 湊屋 街子; 水谷 太; 苣木 洋一; 岸 玲子, 日本衛生学雑誌, 73, Suppl., S235, S235, Mar. 2018
  (一社)日本衛生学会, Japanese
• 胎児期の両親の喫煙と幼児期におけるADHD症状の関連
  湊屋 街子; 伊藤 佐智子; 小林 澄貴; 山崎 圭子; 宮下 ちひろ; 荒木 敦子; 岸 玲子, 日本衛生学雑誌, 73, Suppl., S243, S243, Mar. 2018
  (一社)日本衛生学会, Japanese
• 胎児期のPCB類曝露による児のH19・LINE-1のDNAメチル化への影響 北海道スタディ
  小林 澄貴; 佐田 文宏; 宮下 ちひろ; 三浦 りゅう; ゴウダルジ・ホウマヌ; 荒木 敦子; 梶原 淳睦; 堀 就英; 岸 玲子, 日本衛生学雑誌, 73, Suppl., S243, S243, Mar. 2018
  (一社)日本衛生学会, Japanese
• 両親の教育歴と児のSmall for gestational ageとの媒介要因分析 北海道スタディ
  田村 菜穂美; 花岡 知之; 伊藤 久美子; 伊藤 佐智子; 宮下 ちひろ; 荒木 敦子; 小笠原 克彦; 岸 玲子, 日本衛生学雑誌, 73, Suppl., S244, S244, Mar. 2018
  (一社)日本衛生学会, Japanese
• マタニティヨガ実践と切迫早産,早産との関連に関する検討(エコチル調査北海道追加調査)
  川西 康之; 岸 玲子; 吉岡 英治; 西條 泰明; 吉田 貴彦; 宮本 敏伸; 千石 一雄; 伊藤 善也; 伊藤 佐智子; 宮下 ちひろ; 荒木 敦子, 日本産科婦人科学会雑誌, 70, 2, 787, 787, Feb. 2018
  (公社)日本産科婦人科学会, Japanese
• マタニティヨガ実践と切迫早産,早産との関連に関する検討(エコチル調査北海道追加調査)
  川西 康之; 岸 玲子; 吉岡 英治; 西條 泰明; 吉田 貴彦; 宮本 敏伸; 千石 一雄; 伊藤 善也; 伊藤 佐智子; 宮下 ちひろ; 荒木 敦子, 日本産科婦人科学会雑誌, 70, 2, 787, 787, Feb. 2018
  (公社)日本産科婦人科学会, Japanese
• 胎児期の有機フッ素化合物曝露が7歳のアレルギーに及ぼす影響-北海道スタディ
  アイツバマイ ゆふ; 荒木敦子; 宮下ちひろ; 岡田恵美子; 岡田恵美子; 樫野郁子; 樫野郁子; グウダルジ ホウマヌ; グウダルジ ホウマヌ; 松浦英幸; 岸玲子, 日本衛生学雑誌(Web), 73, Supplement, 2018
• 胎児期ダイオキシン類曝露による第二次性徴への影響 環境と子供の健康北海道スタディ
  宮下 ちひろ; 荒木 敦子; 三井 貴彦; 伊藤 佐智子; 梶原 淳睦; 堀 就英; 長 和俊; 守屋 仁彦; 篠原 信雄; 岸 玲子, 北海道公衆衛生学雑誌, 31, 1特別付録, 46, 46, Nov. 2017
  北海道公衆衛生学会, Japanese
• 胎児期ダイオキシン類曝露による第二次性徴への影響 環境と子供の健康北海道スタディ
  宮下 ちひろ; 荒木 敦子; 三井 貴彦; 伊藤 佐智子; 梶原 淳睦; 堀 就英; 長 和俊; 守屋 仁彦; 篠原 信雄; 岸 玲子, 北海道公衆衛生学雑誌, 31, 1特別付録, 46, 46, Nov. 2017
  北海道公衆衛生学会, Japanese
• ヒトマクロファージ様THP‐1細胞の遺伝子発現に及ぼすDEHP及びMEHPの曝露影響
  小島弘幸; 武内伸治; 室本竜太; 岸玲子; 荒木敦子, 日本免疫毒性学会学術年会講演要旨集, 24th, 93, Aug. 2017
  Japanese
• Effects of Environmental Chemicals in Indoor Air and House Dust on Inhabitant Health
  アイツバマイ ゆふ; 荒木 敦子; 岸 玲子, 環境技術, 46, 7, 372, 377, Jul. 2017
  環境技術学会, Japanese
• 住環境における健康リスク要因とそのマネジメント 科学的エビデンスに基づく「シックハウス症候群相談マニュアル改訂版」の作成について
  岸 玲子; 東 賢一; 西條 泰明; 柴田 英治; 田中 正敏; 河合 俊夫; 大和 浩; 吉野 博; 大澤 元毅; 増地 あゆみ; 荒木 敦子; アイツバマイ ゆふ; 湊屋 街子, 日本衛生学雑誌, 72, Suppl., S138, S138, Mar. 2017
  (一社)日本衛生学会, Japanese
• 住環境における健康リスク要因とそのマネジメント 室内環境中のハウスダストによる健康影響
  荒木 敦子; アイツバマイ ゆふ; 岸 玲子, 日本衛生学雑誌, 72, Suppl., S138, S138, Mar. 2017
  (一社)日本衛生学会, Japanese
• 胎児期有機フッ素化合物曝露と臍帯血中アディポカイン濃度の関係 北海道スタディ
  湊屋 街子; 伊藤 佐智子; 宮下 ちひろ; 荒木 敦子; 佐々木 成子; 岩崎 雄介; 岸 玲子, 日本衛生学雑誌, 72, Suppl., S198, S198, Mar. 2017
  (一社)日本衛生学会, English
• 胎児期BPA曝露による7歳までの喘鳴・アトピー性皮膚炎への影響 北海道スタディ
  アイツバマイ ゆふ; 宮下 ちひろ; 荒木 敦子; 湊屋 街子; 山本 潤; 松村 徹; 佐々木 成子; 岸 玲子, 日本衛生学雑誌, 72, Suppl., S198, S198, Mar. 2017
  (一社)日本衛生学会, Japanese
• ダイオキシン類の胎児期曝露による児のアレルギーへの影響 北海道スタディ
  宮下 ちひろ; 荒木 敦子; 伊藤 佐智子; 湊屋 街子; 小林 澄貴; アイツバマイ ゆふ; 梶原 淳睦; 戸高 尊; 岸 玲子, 日本衛生学雑誌, 72, Suppl., S199, S199, Mar. 2017
  (一社)日本衛生学会, Japanese
• 殺虫用途の農薬への曝露とADHDを中心とした神経発達障害との関連についての疫学研究動向
  西原 進吉; 荒木 敦子; 宮下 ちひろ; 山崎 圭子; 岸 玲子, 北海道公衆衛生学雑誌, 30, 2, 27, 40, Mar. 2017
  北海道公衆衛生学会, Japanese
• 「シックハウス症候群に関する相談マニュアル改訂新版」の作成 公衆衛生分野での活用に向けて
  荒木 敦子; アイツバマイ ゆふ; 西條 泰明; 湊屋 街子; 吉野 博; 東 賢一; 河合 俊夫; 大和 浩; 大澤 元毅; 柴田 英治; 田中 正敏; 増地 あゆみ; 岸 玲子, 北海道公衆衛生学雑誌, 30, 1特別付録, 55, 55, Oct. 2016
  北海道公衆衛生学会, Japanese
• 最近のDOHaD研究のトピックスと地域を基盤とする研究 環境省「子どもの健康と環境に関する全国調査(エコチル調査)」 北海道ユニットセンター・旭川サブユニットの参加者プロファイル
  西條 泰明; 川西 康之; 吉岡 英治; 伊藤 俊弘; 伊藤 善也; 伊藤 佐智子; 宮下 ちひろ; 荒木 敦子; 岸 玲子, 日本衛生学雑誌, 71, Suppl., S168, S168, May 2016
  (一社)日本衛生学会, Japanese
• ダイオキシン類異性体の曝露が胎生期の性ホルモンに与える影響 北海道スタディ
  宮下 ちひろ; 荒木 敦子; 三井 貴彦; 伊藤 佐知子; 佐々木 成子; 戸高 尊; 梶原 淳睦; 長 和俊; 野々村 克也; 岸 玲子, 日本衛生学雑誌, 71, Suppl., S192, S192, May 2016
  (一社)日本衛生学会, Japanese
• DEHP曝露による胎生期ステロイドホルモンプロファイルへの影響 北海道スタディ
  荒木 敦子; グウダルジ・ホウマヌ; 三井 貴彦; 那須 民江; 宮下 ちひろ; 伊藤 佐智子; 佐々木 成子; 長 和俊; 野々村 克也; 岸 玲子, 日本衛生学雑誌, 71, Suppl., S192, S192, May 2016
  (一社)日本衛生学会, Japanese
• FLG変異とフタル酸エステル曝露による児のADへの影響 北海道スタディ
  アイツバマイ ゆふ; 荒木 敦子; 乃村 俊史; 河合 俊夫; 坪井 樹; 叢 石; 宮下 ちひろ; 池野 多美子; 清水 宏; 岸 玲子, 日本衛生学雑誌, 71, Suppl., S192, S192, May 2016
  (一社)日本衛生学会, Japanese
• 母の喫煙曝露と胎児発育との関連 遺伝的なハイリスクについて 北海道スタディ
  小林 澄貴; 佐田 文宏; 佐々木 成子; Braimoh TitilolaSerifat; 荒木 敦子; 宮下 ちひろ; Goudarzi Houman; 小林 祥子; 岸 玲子, 日本衛生学雑誌, 71, Suppl., S193, S193, May 2016
  (一社)日本衛生学会, Japanese
• 胎児期の有機塩素系農薬曝露が母児の甲状腺ホルモンに及ぼす影響 北海道スタディ
  山崎 圭子; 宮下 ちひろ; 伊藤 佐智子; 荒木 敦子; 小林 祥子; 水谷 太; 苣木 洋一; 岸 玲子, 日本衛生学雑誌, 71, Suppl., S194, S194, May 2016
  (一社)日本衛生学会, Japanese
• 児の出生時体格に妊婦の喫煙とAHR、CYP1A1、XRCC1遺伝子型の組合せが影響する―北海道スタディ
  小林澄貴; 佐田文宏; 佐々木成子; チチローラ・セリファト・ブライモー; 荒木敦子; 宮下ちひろ; ホウマヌ・ゴウダルジ; 小林祥子; 岸玲子, 北海道医学雑誌, 91, 81, 2016
  Japanese, Introduction scientific journal
• 前向きコーホート研究に基づく先天異常,免疫アレルギーおよび小児発達障害のリスク評価と環境化学物質に対する遺伝的感受性の解明 胎児期有機フッ素化合物曝露影響の臍帯血網羅的エピゲノム解析
  岸玲子; 荒木敦子; 宮下ちひろ; 佐々木成子; 石塚真由美; 小林祥子; 三浦りゅう; 安住薫; 中澤裕之, 前向きコーホート研究に基づく先天異常、免疫アレルギーおよび小児発達障害のリスク評価と環境化学物質に対する遺伝的感受性の解明 平成27年度 総括・分担研究報告書, 168‐185, 2016
  Japanese
• 妊娠初期における就労女性の有害物質の取扱いが児の流・死産に及ぼす影響
  小林 澄貴; 宮下 ちひろ; 荒木 敦子; 池野 多美子; 伊藤 佐智子; Goudarzi Houman; 花岡 知之; 岸 玲子, 北海道公衆衛生学雑誌, 29, 1特別付録, 25, 25, Nov. 2015
  北海道公衆衛生学会, Japanese
• 胎児期ダイオキシン類曝露による臍帯血中性ホルモンへの影響 環境と子供の健康北海道スタディ
  宮下 ちひろ; 荒木 敦子; 三井 貴彦; 伊藤 佐知子; 佐々木 成子; 戸高 尊; 梶原 淳睦; 長和 俊; 野々村 克也; 岸 玲子, 北海道公衆衛生学雑誌, 29, 1特別付録, 26, 26, Nov. 2015
  北海道公衆衛生学会, Japanese
• 胎児期ビスフェノールA曝露による臍帯血中のアディポカイン、出生体重、子どもの体重への影響 北海道スタディ
  湊屋 街子; 佐々木 成子; 荒木 敦子; 宮下 ちひろ; 山本 潤; 松村 徹; 岸 玲子, 北海道公衆衛生学雑誌, 29, 1特別付録, 27, 27, Nov. 2015
  北海道公衆衛生学会, Japanese
• 北海道のエコチル調査の集計結果 生後2歳までの食物アレルギーの頻度および食品の摂食状況について
  アイツバマイ ゆふ; 西條 泰明; 伊藤 善也; 村林 宏; 吉岡 英治; 川西 康之; 水上 尚典; 有賀 正; 長和 俊; 白石 秀明; 千石 一雄; 宮本 敏伸; 東 寛; 堤 裕幸; 遠藤 俊明; 馬場 剛; 小林 正樹; 荒木 敦子; 池野 多美子; 宮下 ちひろ; 伊藤 佐智子; 土川 陽子; 湊屋 街子; 小林 澄貴; 山崎 圭子; 西原 進吉; 田村 菜穂美; 岸 玲子, 北海道公衆衛生学雑誌, 29, 1特別付録, 36, 36, Nov. 2015
  北海道公衆衛生学会, Japanese
• エコチル調査北海道ユニットセンター旭川サブユニット参加者における母体基本属性および周産期転帰と、その全国データとの比較
  川西 康之; 西條 泰明; 伊藤 善也; 中木 良彦; 吉岡 英治; 伊藤 俊弘; 吉田 貴彦; 宮本 敏伸; 千石 一雄; 東 寛; 土川 陽子; 宮下 ちひろ; 荒木 敦子; 岸 玲子, 北海道公衆衛生学雑誌, 29, 1特別付録, 41, 41, Nov. 2015
  北海道公衆衛生学会, Japanese
• Effects of maternal AHR, CYP1A1 and GSTM1 polymorphisms and dioxins on infant birth size
  Kobayashi S; Miyashita C; Sasaki S; Araki A; Sata F; Ban S; Kajiwara J; Todaka T; Kishi R, 27th conference of the International Society of Environmental Epidemiology: ISEE 2015 Abstracts, Aug. 2015
  English, Summary international conference
• 母体への環境化学物質曝露と胎児期ホルモン環境が身体的変化に与える影響 第2指/第4指比との関連性について
  三井 貴彦; 荒木 敦子; 宮下 ちひろ; 橘田 岳也; 守屋 仁彦; 長 和俊; 森岡 圭太; 伊藤 佐智子; 篠原 信雄; 岸 玲子; 野々村 克也, 日本生殖医学会雑誌, 60, 3, 196, 196, Jul. 2015
  (一社)日本生殖医学会, Japanese
• 胎児期における男性ホルモンへの曝露が小児期の脳の性分化に与える影響について
  三井 貴彦; 荒木 敦子; 伊藤 佐智子; 宮下 ちひろ; 橘田 岳也; 守屋 仁彦; 長 和俊; 森岡 圭太; 篠原 信雄; 岸 玲子; 野々村 克也, 泌尿器外科, 28, 5, 1011, 1011, May 2015
  医学図書出版(株), Japanese
• 北海道スタディ出生コホートを用いたアレルギー疾患とフィラグリン遺伝子変異の関連解析
  乃村 俊史; 竹田 真依; 鈴木 翔多朗; 清水 宏; 荒木 敦子; 宮下 ちひろ; 池野 多美子; 佐々木 成子; 岸 玲子; 秋山 真志, 角化症研究会記録集, 29, 12, 15, Mar. 2015
  角化症研究会事務局, Japanese
• 臍帯血ビスフェノールA濃度と児のIGF2 DNAメチル化との関連 北海道スタディ
  小林 祥子; 安住 薫; 佐々木 成子; 松村 徹; 山本 潤; 石塚 真由美; 宮下 ちひろ; 池野 多美子; 荒木 敦子; 岸 玲子, 日本衛生学雑誌, 70, Suppl., S173, S173, Mar. 2015
  (一社)日本衛生学会, Japanese
• ダイオキシン類曝露と胎児発育との関連 遺伝的なリスクについて 北海道スタディ
  小林 澄貴; 宮下 ちひろ; 佐々木 成子; 荒木 敦子; 佐田 文宏; 坂 晋; 梶原 淳睦; 戸高 尊; 岸 玲子, 日本衛生学雑誌, 70, Suppl., S181, S181, Mar. 2015
  (一社)日本衛生学会, Japanese
• 胎児期MEHP曝露による神経行動発達への影響 北海道スタディ
  湊屋 街子; 佐々木 成子; 中島 そのみ; 那須 民江; 後藤 裕子; 宮下 ちひろ; 荒木 敦子; 小林 澄貴; 池野 多美子; 岸 玲子, 日本衛生学雑誌, 70, Suppl., S182, S182, Mar. 2015
  (一社)日本衛生学会, Japanese
• 有機塩素系農薬への胎児期曝露による児の性ホルモン濃度への影響 北海道スタディ
  荒木 敦子; 宮下 ちひろ; 金澤 文子; 伊藤 佐智子; 三井 貴彦; 佐々木 成子; 水谷 太; 苣木 洋一; 野々村 克也; 岸 玲子, 日本衛生学雑誌, 70, Suppl., S182, S182, Mar. 2015
  (一社)日本衛生学会, Japanese
• 有機塩素系農薬が乳幼児の免疫に与える影響 環境と子どもの健康北海道スタディー
  宮下 ちひろ; 金澤 文子; 佐々木 成子; 池野 多美子; 荒木 敦子; 伊藤 佐智子; 小林 祥子; 水谷 太; 苣木 洋一; 岸 玲子, 日本衛生学雑誌, 70, Suppl., S183, S183, Mar. 2015
  (一社)日本衛生学会, Japanese
• 胎児期の有機塩素系農薬曝露が6ヵ月児の精神運動発達に及ぼす影響 北海道スタディ
  山崎 圭子; 宮下 ちひろ; 中島 そのみ; 池野 多美子; 荒木 敦子; 伊藤 佐智子; 小林 祥子; 水谷 太; 苣木 洋一; 岸 玲子, 日本衛生学雑誌, 70, Suppl., S183, S183, Mar. 2015
  (一社)日本衛生学会, Japanese
• 児の出生体重と母親の社会経済要因との関連についての疫学研究 北海道スタディ
  田村 菜穂美; 伊藤 久美子; 花岡 知之; 喜多 歳子; 西原 進吉; 宮下 ちひろ; 荒木 敦子; 小笠原 克彦; 岸 玲子, 日本衛生学雑誌, 70, Suppl., S190, S190, Mar. 2015
  (一社)日本衛生学会, Japanese
• 第2指・第4指比(2D/4D比)に影響を及ぼす遺伝要因の検討
  佐田 文宏; 江藤 亜紀子; 金谷 泰宏; 三井 貴彦; 荒木 敦子; 岸 玲子; 野々村 克也, 日本衛生学雑誌, 70, Suppl., S220, S220, Mar. 2015
  (一社)日本衛生学会, Japanese
• マタニティヨガの周産期予後改善効果に関する研究
  川西 康之; 中木 良彦; 伊藤 俊弘; 吉岡 英治; 吉田 貴彦; 伊藤 善也; 宮下 ちひろ; 荒木 敦子; 岸 玲子; 千石 一雄; 西條 泰明, 北海道産科婦人科学会会誌, 59, 1, 206, 207, Mar. 2015
  北海道産科婦人科学会, Japanese
• 前向きコーホート研究に基づく先天異常,免疫アレルギーおよび小児発達障害のリスク評価と環境化学物質に対する遺伝的感受性の解明 胎児期ダイオキシンPCBs曝露が児の臍帯血DNAメチル化に及ぼす影響
  岸玲子; 荒木敦子; 梶原淳睦; 佐々木成子; 石塚真由美; 小林祥子; 安住薫; 小林澄貴; 蜂谷紀之; 安武章; 戸高尊, 前向きコーホート研究に基づく先天異常、免疫アレルギーおよび小児発達障害のリスク評価と環境化学物質に対する遺伝的感受性の解明 平成26年度 総括・分担研究報告書, 134, 143, 2015
  Japanese
• 環境省「エコチル調査」北海道ユニットセンターにおけるこれまでの活動報告
  荒木 敦子; 伊藤 善也; 西條 泰明; 池野 多美子; 宮下 ちひろ; 伊藤 佐智子; 土川 陽子; 田村 菜穂美; 湊屋 街子; 吉岡 英治; 川西 康之; 村林 宏; 岸 玲子, 環境ホルモン学会研究発表会要旨集, 17回, 65, 65, Dec. 2014
  環境ホルモン学会(日本内分泌撹乱化学物質学会), Japanese
• さい帯血と血液のダイオキシン及びPCB類の組成比較
  梶原 淳睦; 戸高 尊; 平川 博仙; 宮下 ちひろ; 伊藤 佐智子; 佐々木 成子; 荒木 敦子; 岸 礼子, 環境ホルモン学会研究発表会要旨集, 17回, 69, 69, Dec. 2014
  環境ホルモン学会(日本内分泌撹乱化学物質学会), Japanese
• 胎児期の有機塩素系農薬が小児アレルギー発症に与える影響 環境と子どもの健康北海道スタディ
  宮下 ちひろ; 金澤 文子; 池野 多美子; 荒木 敦子; 伊藤 佐智子; 小林 澄貴; 湊屋 街子; Goudarzi Houman; 小林 祥子; 田村 菜穂美; 水谷 太; 苣木 洋一; 岸 玲子, 北海道公衆衛生学雑誌, 28, 1特別付録, 44, 44, Dec. 2014
  北海道公衆衛生学会, Japanese
• 胎児期の母の受動喫煙が児の出生時体格に及ぼす影響 遺伝環境交互作用について
  小林 澄貴; 佐々木 成子; 佐田 文宏; 宮下 ちひろ; 池野 多美子; 荒木 敦子; 岸 玲子, 北海道公衆衛生学雑誌, 28, 1特別付録, 45, 45, Dec. 2014
  北海道公衆衛生学会, Japanese
• 北海道3地区における妊婦の食習慣・運動習慣の実態について 環境省「子どもの健康と環境に関する全国調査(エコチル調査)」 北海道ユニットセンター登録者のデータから
  湊屋 街子; 西條 泰明; 伊藤 善也; 荒木 敦子; 池野 多美子; 宮下 ちひろ; 伊藤 佐智子; 小林 澄貴; 土川 陽子; 田村 菜穂美; 吉岡 英治; 川西 康之; 村林 宏; 岸 玲子; エコチル調査北海道ユニットセンター事務局, 北海道公衆衛生学雑誌, 28, 1特別付録, 57, 57, Dec. 2014
  北海道公衆衛生学会, Japanese
• 生殖次世代影響の疫学研究における生体内短半減期物質の評価 フタル酸エステル類の胎児期曝露による次世代影響に関する疫学研究
  荒木 敦子; 岸 玲子, 日本衛生学雑誌, 69, Suppl., S143, S143, May 2014
  (一社)日本衛生学会, Japanese
• PFOS・PFOAの胎児期曝露が与える児の出生時性ホルモン濃度への影響
  伊藤 佐智子; 荒木 敦子; 宮下 ちひろ; 中澤 裕之; 三井 貴彦; 長 和俊; 佐々木 成子; 池野 多美子; 野々村 克也; 岸 玲子, 日本衛生学雑誌, 69, Suppl., S196, S196, May 2014
  (一社)日本衛生学会, Japanese
• 児の出生体重と母親の社会経済要因との関連についての疫学研究
  田村 菜穂美; 伊藤 久美子; 小林 澄貴; 岡田 恵美子; 喜多 歳子; ホウマヌ・ゴウダルジ; 宮下 ちひろ; 荒木 敦子; 池野 多美子; 岸 玲子, 日本衛生学雑誌, 69, Suppl., S204, S204, May 2014
  (一社)日本衛生学会, Japanese
• DEHPへの胎児期曝露による児の性ホルモン濃度への影響
  荒木 敦子; 三井 貴彦; 宮下 ちひろ; 那須 民江; 伊藤 佐智子; 佐々木 成子; 長 和俊; 池野 多美子; 野々村 克也; 岸 玲子, 日本衛生学雑誌, 69, Suppl., S211, S211, May 2014
  (一社)日本衛生学会, Japanese
• 胎児期ビスフェノールA曝露による臍帯血中性ホルモン濃度への影響
  佐々木 成子; 山本 潤; 荒木 敦子; 伊藤 佐智子; 宮下 ちひろ; 三井 貴彦; 長 和俊; 野々村 克也; 松村 徹; 岸 玲子, 日本衛生学雑誌, 69, Suppl., S215, S215, May 2014
  (一社)日本衛生学会, Japanese
• 母体への環境化学物質曝露と胎児期ホルモン環境が身体的変化に与える影響 第2指/第4指比との関連性について
  三井 貴彦; 荒木 敦子; 宮下 ちひろ; 今井 紋子; 佐藤 早基子; 橘田 岳也; 守屋 仁彦; 長 和俊; 森岡 圭太; 伊藤 佐智子; 岸 玲子; 野々村 克也, 日本泌尿器科学会総会, 102回, 472, 472, Apr. 2014
  (一社)日本泌尿器科学会総会事務局, Japanese
• 妊婦の受動喫煙が児の出生時体格へ及ぼす影響：遺伝的なハイリスク群について―環境と子どもの健康に関する北海道スタディ―
  小林澄貴; 佐々木成子; 佐田文宏; 宮下ちひろ; 池野多美子; 荒木敦子; 岸玲子, 北海道小児保健研究会会誌, 35, 39, 2014
  Japanese
• 前向きコーホート研究に基づく先天異常,免疫アレルギーおよび小児発達障害のリスク評価と環境化学物質に対する遺伝的感受性の解明 胎児期の環境化学物質曝露が児のIGF2/H19メチル化に及ぼす影響
  安住薫; 岸玲子; 佐々木成子; 石塚真由美; 梶原淳睦; 宮下ちひろ; 池野多美子; 荒木敦子; 小林祥子; 小林澄貴; 中澤裕之; 那須民江; 蜂谷紀之; 安武章, 前向きコーホート研究に基づく先天異常、免疫アレルギーおよび小児発達障害のリスク評価と環境化学物質に対する遺伝的感受性の解明 平成25年度 総括・分担研究報告書, 71, 79, 2014
  Japanese
• 胎児のホルモン環境に影響を及ぼす要因の検討 ホルモン関連遺伝子多型と臍帯血ホルモン濃度
  佐田 文宏; 江藤 亜紀子; 荒木 敦子; 三井 貴彦; 金谷 泰宏; 岸 玲子; 野々村 克也, 環境ホルモン学会研究発表会要旨集, 16回, 170, 170, Dec. 2013
  環境ホルモン学会(日本内分泌撹乱化学物質学会), Japanese
• 札幌市128軒のハウスダスト中リン酸トリエステル類濃度と小学生のアレルギー疾患との関連
  多島 秀司; 荒木 敦子; 河合 俊夫; 坪井 樹; アイツバマイ ゆふ; 叢 石; 吉岡 英治; 岸 玲子, 北海道公衆衛生学雑誌, 27, 1特別付録, 44, 44, Nov. 2013
  北海道公衆衛生学会, Japanese
• 札幌市内小学生の自宅における暖房、および機械換気の有無と児童の喘息
  叢 石; 荒木 敦子; 鵜川 重和; アイツバマイ ゆふ; 多島 秀司; 金澤 文子; 湯浅 資之; 玉腰 暁子; 岸 玲子, 北海道公衆衛生学雑誌, 27, 1特別付録, 45, 45, Nov. 2013
  北海道公衆衛生学会, Japanese
• 尿中フタル酸代謝物濃度とハウスダスト中フタル酸エステル濃度との関連 札幌市児童における調査
  アイツバマイ ゆふ; 荒木 敦子; 河合 俊夫; 坪井 樹; 多島 秀司; 叢 石; 湯浅 資之; 金澤 文子; 玉腰 暁子; 岸 玲子, 北海道公衆衛生学雑誌, 27, 1特別付録, 47, 47, Nov. 2013
  北海道公衆衛生学会, Japanese
• 北海道3地区における妊婦の喫煙率および喫煙開始年齢について 環境省「子どもの環境と健康に関する全国調査(エコチル調査)」より
  荒木 敦子; 西條 泰明; 伊藤 善也; 池野 多美子; 宮下 ちひろ; 伊藤 佐智子; 土川 陽子; 吉岡 英治; 川西 康之; 村林 宏; 岸 玲子, 北海道公衆衛生学雑誌, 27, 1特別付録, 52, 52, Nov. 2013
  北海道公衆衛生学会, Japanese
• マタニティヨガの周産期予後改善効果に関する研究(エコチル調査北海道追加調査)
  川西 康之; 中木 良彦; 伊藤 俊弘; 吉岡 英治; 吉田 貴彦; 伊藤 善也; 池野 多美子; 荒木 敦子; 岸 玲子; 西條 泰明, 日本公衆衛生学会総会抄録集, 72回, 366, 366, Oct. 2013
  日本公衆衛生学会, Japanese
• マタニティヨガの周産期予後改善効果に関する研究
  川西 康之; 中木 良彦; 伊藤 俊弘; 吉岡 英治; 吉田 貴彦; 伊藤 善也; 宮下 ちひろ; 荒木 敦子; 岸 玲子; 千石 一雄; 西條 泰明, 北日本産科婦人科学会総会・学術講演会プログラム・抄録集, 61回, 100, 100, Sep. 2013
  東北連合産科婦人科学会・北日本産科婦人科学会, Japanese
• GC/MSによるヒトの尿中2-エチルヘキサノールの定量 フタル酸ジエステル類評価としての無水フタル酸可塑剤・難燃剤曝露と小児の健康影響
  河合 俊夫; 坪井 樹; 荒木 敦子; アイツバマイ ゆふ; 岸 玲子, 産業衛生学雑誌, 55, 臨増, 439, 439, May 2013
  (公社)日本産業衛生学会, Japanese
• 札幌市の小学生4,500名を対象とした住環境とアトピー性皮膚炎に関する調査
  鵜川 重和; 荒木 敦子; 金澤 文子; 湯浅 資之; 岸 玲子, 北海道醫學雜誌 = Acta medica Hokkaidonensia, 88, 2, 95, 95, 01 Apr. 2013
  Japanese
• フタル酸エステル尿中代謝物の同時測定方法の開発可塑剤難燃剤曝露と小児の健康影響(1)
  坪井 樹; 河合 俊夫; 荒木 敦子; アイツバマイ ゆふ; 岸 玲子, 日本衛生学雑誌, 68, Suppl., S159, S159, Mar. 2013
  (一社)日本衛生学会, Japanese
• アレルギーとダスト中フタル酸エステル濃度 可塑剤・難燃剤曝露と小児の健康影響(3)
  アイツバマイ ゆふ; 荒木 敦子; 坪井 樹; 河合 俊夫; 多島 秀司; 叢 石; 吉岡 英治; 玉腰 暁子; 岸 玲子, 日本衛生学雑誌, 68, Suppl., S159, S159, Mar. 2013
  (一社)日本衛生学会, Japanese
• フタル酸ジエステル類評価としての無水フタル酸可塑剤・難燃剤曝露と小児の健康影響(2)
  河合 俊夫; 坪井 樹; 荒木 敦子; アイツバマイ ゆふ; 岸 玲子, 日本衛生学雑誌, 68, Suppl., S204, S204, Mar. 2013
  (一社)日本衛生学会, Japanese
• 児童の尿中フタル酸代謝物濃度とアレルギー 可塑剤、難燃剤の小児への健康影響(4)
  荒木 敦子; 坪井 樹; 河合 俊夫; アイツバマイ ゆふ; 多島 秀司; 叢 石; 鵜川 重一; 吉岡 英治; 岸 玲子, 日本衛生学雑誌, 68, Suppl., S204, S204, Mar. 2013
  (一社)日本衛生学会, Japanese
• ハウスダスト中フタル酸エステルと住環境との関連
  アイツバマイゆふ; 荒木敦子; 河合俊夫; 坪井樹; 斎藤育江; 吉岡栄治; 金澤文子; 多島秀司; 叢石; 玉腰暁子; 岸玲子, 北海道医学雑誌, 88, 6, 2013
• 可塑剤・難燃剤の曝露評価手法の開発と小児アレルギー・リスク評価への応用 尿中2-エチル-1-ヘキサノールの分析方法と測定事例
  河合 俊夫; 坪井 樹; 荒木 敦子; アイツバマイゆふ; 岸 玲子, 産業衛生学雑誌, 55, 1, 36, 36, Jan. 2013
  (公社)日本産業衛生学会, Japanese
• The relationship between exposure to microbial volatile organic compound and allergy prevalence in single-family homes
  荒木 敦子; 金沢 文子; 河合 俊夫; 永滝 陽子; 森本 兼曩; 中山 邦夫; 柴田 英治; 田中 正敏; 瀧川 智子; 吉村 健清; 力 寿雄; 西條 泰明; 岸 玲子, 北海道醫學雜誌 = Acta medica Hokkaidonensia, 87, 6, 286, 286, 01 Nov. 2012
  Japanese
• 小学生の住宅におけるハウスダスト中のエンドトキシンならびにβ-グルカン量とアレルギー性疾患に関する研究
  叢 石; 荒木 敦子; アイツバマイ ゆふ; 竹田 智哉; 早川 敦司; 吉岡 英治; 多島 秀司; 鵜川 重和; 玉腰 暁子; 岸 玲子, 北海道公衆衛生学雑誌, 26, 1特別付録, 33, 33, Nov. 2012
  北海道公衆衛生学会, Japanese
• ハウスダスト中に含まれるリン酸トリエステル類の濃度と住居環境
  多島 秀司; 荒木 敦子; 坪井 樹; 河合 俊夫; 斎藤 育江; アイツバマイ ゆふ; 竹田 智哉; 鵜川 重和; 吉岡 英治; 岸 玲子, 北海道公衆衛生学雑誌, 26, 1特別付録, 34, 34, Nov. 2012
  北海道公衆衛生学会, Japanese
• 環境省「エコチル調査」に関する意識調査と広報活動の課題
  荒木 敦子; 尾西 奈江; 中瀬 督久; 岸 玲子; エコチル調査北海道ユニットセンター事務局, 北海道公衆衛生学雑誌, 26, 1特別付録, 38, 38, Nov. 2012
  北海道公衆衛生学会, Japanese
• 札幌市の小学生4500名を対象とした住環境と喘息、アトピー性皮膚炎に関する調査
  鵜川 重和; 荒木 敦子; 金澤 文子; 湯浅 資之; 吉岡 英治; 岸 玲子, 日本公衆衛生学会総会抄録集, 71回, 333, 333, Oct. 2012
  日本公衆衛生学会, Japanese
• シックハウス症候群研究最近の動向 シックハウス症候群に関する全国規模の疫学研究 化学物質、湿度環境、生物学的要因
  荒木 敦子; 西條 泰明; 田中 正敏; 瀧川 智子; 吉村 健清; 森本 兼曩; 柴田 英治; 河合 俊夫; 斎藤 育江; 岸 玲子, 日本衛生学雑誌, 67, 2, 232, 232, Feb. 2012
  (一社)日本衛生学会, Japanese
• 札幌市小学生の喘息・鼻結膜炎有訴と自宅環境および気中VOC・MVOC濃度
  荒木 敦子; アイツバマイ ゆふ; 河合 俊夫; 坪井 樹; 竹田 智哉; 多島 秀司; 鵜川 重和; 叢 石; 吉岡 英治; 岸 玲子, 日本衛生学雑誌, 67, 2, 285, 285, Feb. 2012
  (一社)日本衛生学会, Japanese
• 小学生のシックハウス症候群の有訴と床ダスト中有機リン酸トリエステル類濃度との関係
  多島 秀司; 荒木 敦子; 斎藤 育江; 河合 俊夫; 坪井 樹; アイツバマイ ゆふ; 竹田 智哉; 吉岡 英治; 鵜川 重和; 岸 玲子, 日本衛生学雑誌, 67, 2, 285, 285, Feb. 2012
  (一社)日本衛生学会, Japanese
• ヒトの出産前後における血液DEHP代謝物濃度の解析
  田川 雅大; 内藤 久雄; 林 由美; 川野 愛子; 佐々木 成子; 荒木 敦子; 小林 澄貴; 岸 玲子, 日本衛生学雑誌, 67, 2, 303, 303, Feb. 2012
  (一社)日本衛生学会, Japanese
• 室内空気質中フタル酸エステル類曝露とアレルギーへの影響
  アイツバマイ ゆふ; 荒木 敦子; 岸 玲子, Endocrine Disrupter News Letter, 15, 1, 2, 2, 2012
  日本内分泌撹乱化学物質学会（環境ホルモン学会）, Japanese
• 自宅空気中化学物質濃度とシックハウス症候群に関する調査研究 札幌市小学生を対象として
  荒木 敦子; アイツバマイ ゆふ; 坪井 樹; 河合 俊夫; 竹田 智哉; 早川 敦司; 吉岡 英治; 多島 秀司; 叢 石; 鵜川 重和; 岸 玲子, 北海道公衆衛生学雑誌, 25, 1特別付録, 50, 50, Nov. 2011
  北海道公衆衛生学会, Japanese
• 自宅住環境とアトピー性皮膚炎に関する調査 札幌市の小学生4,500名を対象として
  鵜川 重和; 荒木 敦子; 金澤 文子; 湯浅 資之; アイツバマイ ゆふ; 吉岡 英治; 叢 石; 多島 秀司; 岸 玲子, 北海道公衆衛生学雑誌, 25, 1特別付録, 51, 51, Nov. 2011
  北海道公衆衛生学会, Japanese
• 小学生の住宅におけるハウスダスト中のエンドトキシンならびにβ-グルカン量と住宅特徴に関する調査
  叢 石; 荒木 敦子; アイツバマイ ゆふ; 竹田 智哉; 早川 敦司; 吉岡 英治; 多島 秀司; 鵜川 重和; 岸 玲子, 北海道公衆衛生学雑誌, 25, 1特別付録, 54, 54, Nov. 2011
  北海道公衆衛生学会, Japanese
• 札幌市戸建住宅における3年の室内環境とシックハウス症候群有訴の変化
  荒木 敦子; 金澤 文子; 西條 泰明; 岸 玲子, 日本衛生学雑誌, 66, 3, 589, 599, May 2011
  札幌市戸建住宅における3年の室内環境とシックハウス症候群有訴の変化について検討した。調査対象住宅は2004年、2005年、2006年、それぞれ104軒、64軒、41軒で、調査を3年継続した住宅は41軒であった。40軒は木造建築で、41軒の築年の平均は2.3±1.5年であった。全室あるいは居間に換気システムが導入されていたのは24軒であったが、2006年には、このうち6軒は換気システムを使用していなかった。芳香剤および防虫剤を利用する住宅は2006年にはほぼ半減した。ホルムアルデヒドは毎回の調査ですべての住宅から検出したが、経年的な減少傾向を認めた。Aspergillus属の総真菌数に占める割合は低いものの、2006年は2004年、2005年に比べて有意に増加していた。Der1の検出率はいずれの年も78%以上であった。SHS症状は、いずれの年も鼻症状の訴えが最も多かった。, (一社)日本衛生学会, Japanese
• シックハウス症状解明のための超小型、軽量、拡散型サンプラーの開発 VOC測定用サンプラー
  坪井 樹; 河合 俊夫; 乾谷 正樹; 住野 公昭; 荒木 敦子; 岸 玲子, 産業衛生学雑誌, 53, 臨増, 413, 413, May 2011
  (公社)日本産業衛生学会, Japanese
• シックハウス症状解明のための超小型、軽量、拡散型サンプラーの開発 アルデヒド測定用サンプラー
  河合 俊夫; 坪井 樹; 乾谷 正樹; 荒木 敦子; 住野 公昭; 岸 玲子, 産業衛生学雑誌, 53, 臨増, 414, 414, May 2011
  (公社)日本産業衛生学会, Japanese
• 微生物由来VOCによる室内空気室汚染の実情と健康影響
  荒木 敦子; 岸 玲子, 日本衛生学雑誌, 66, 2, 368, 368, Feb. 2011
  (一社)日本衛生学会, Japanese
• 札幌市小学生のシックハウス症候群有訴と自宅の気中化学物質濃度
  荒木 敦子; アイトバマイ ゆふ; 竹田 智哉; 河合 俊夫; 坪井 樹; 早川 敦司; 吉岡 英治; 岸 玲子, 日本衛生学雑誌, 66, 2, 388, 388, Feb. 2011
  (一社)日本衛生学会, Japanese
• シックハウス症候群の原因解明のための全国規模の疫学研究―化学物質および真菌・ダニ等による健康影響の評価と対策―グルカンとシックハウス症候群との関連についての文献調査
  岸玲子; 湯浅資之; 金澤文子; 小林澄貴; 荒木敦子; 宮下ちひろ, シックハウス症候群の原因解明のための全国規模の疫学研究-化学物質及び真菌・ダニ等による健康影響の評価と対策 平成20-22年度 総合研究報告書, 194, 201, 2011
  Japanese
• シックハウス症候群の原因解明のための全国規模の疫学研究―化学物質および真菌・ダニ等による健康影響の評価と対策―学校の室内空気質と生徒におけるシックビル症候群(SBS)の関係についての海外の文献調査
  岸玲子; 湯浅資之; 荒木敦子; 宮下ちひろ; 金澤文子; 小林澄貴, シックハウス症候群の原因解明のための全国規模の疫学研究-化学物質及び真菌・ダニ等による健康影響の評価と対策 平成20-22年度 総合研究報告書, 191, 193, 2011
  Japanese
• 室内環境汚染物質51物質の分析・測定技術
  坪井 樹; 永滝 陽子; 河合 俊夫; 住野 公昭; 荒木 敦子; 大前 和幸; 岸 玲子, 産業衛生学雑誌, 52, 臨増, 431, 431, May 2010
  (公社)日本産業衛生学会, Japanese
• 喫煙者の有無別にみた室内環境化学物質濃度とシックハウス症候群の自覚症状
  アイトバマイ ゆふ; 荒木 敦子; 西條 泰明; 森本 兼曩; 中山 邦夫; 瀧川 智子; 田中 正敏; 柴田 英治; 吉村 健清; 力 寿雄, 日本衛生学雑誌, 65, 2, 309, 309, Apr. 2010
  (一社)日本衛生学会, Japanese
• シックハウス関連物質の活性炭脱着率に関する基礎的検討
  永滝 陽子; 坪井 樹; 河合 俊夫; 清水 英佑; 大前 和幸; 荒木 敦子; 岸 玲子, 産業衛生学雑誌, 52, 1, 52, 53, Jan. 2010
  (公社)日本産業衛生学会, Japanese
• 札幌市小学生を対象としたシックハウス症候群の有訴率と関連要因に関する調査
  荒木 敦子; 湯浅 資之; 金澤 文子; 岸 玲子, 北海道公衆衛生学雑誌, 23, 1特別付録, 69, 69, Nov. 2009
  北海道公衆衛生学会, Japanese
• 全国6地域の一般住宅におけるシックハウス症候群の実態と原因の解明 (第5報)室内空気質中Microbial VOC類の濃度と症状との関係
  荒木 敦子; 河合 俊夫; 永滝 陽子; 金澤 文子; 竹田 誠; 森本 兼曩; 中山 邦夫; 柴田 英治; 田中 正敏; 瀧川 智子; 吉村 健清; 力 寿雄; 岸 玲子, 日本衛生学雑誌, 64, 2, 355, 355, Mar. 2009
  (一社)日本衛生学会, Japanese
• シックハウス症候群の原因解明のための全国規模の疫学研究―化学物質及び真菌・ダニ等による健康影響の評価と対策―グルカンとシックハウス症候群との関連についての文献調査
  岸玲子; 湯浅資之; 金澤文子; 小林澄貴; 荒木敦子; 宮下ちひろ, シックハウス症候群の原因解明のための全国規模の疫学研究-化学物質及び真菌・ダニ等による健康影響の評価と対策 平成20年度 総括・分担研究報告書, 142, 149, 2009
  Japanese
• シックハウス症候群の原因解明のための全国規模の疫学研究―化学物質及び真菌・ダニ等による健康影響の評価と対策―学校の室内空気質と生徒におけるシックビル症候群(SBS)の関係についての海外の文献調査
  岸玲子; 湯浅資之; 荒木敦子; 宮下ちひろ; 金澤文子; 小林澄貴, シックハウス症候群の原因解明のための全国規模の疫学研究-化学物質及び真菌・ダニ等による健康影響の評価と対策 平成20年度 総括・分担研究報告書, 69, 71, 2009
  Japanese
• 札幌市新築戸建住宅における3年間の室内環境変化
  荒木 敦子; 金澤 文子; 竹田 誠; 西條 泰明; 岸 玲子, 北海道公衆衛生学雑誌, 22, 1特別付録, 112, 112, Nov. 2008
  北海道公衆衛生学会, Japanese
• 全国6地域の一般住宅におけるシックハウス症候群の実態と原因の解明(第4報) 室内空気質中Microbial VOC類の濃度と住環境との関係
  荒木 敦子; 河合 俊夫; 永滝 陽子; 竹田 誠; 金澤 文子; 森本 兼曩; 中山 邦夫; 柴田 英治; 田中 正敏; 瀧川 智子; 吉村 健清; 力 寿雄; 岸 玲子, 日本衛生学雑誌, 63, 2, 356, 356, Mar. 2008
  日本衛生学会, Japanese
• 札幌市一般住宅におけるフタル酸エステル、リン酸トリエステルによる室内汚染 実態解明とシックハウス症候群との関連
  金澤 文子; 斎藤 育江; 荒木 敦子; 竹田 誠; 矢口 久美子; 岸 玲子, 日本衛生学雑誌, 63, 2, 357, 357, Mar. 2008
  (一社)日本衛生学会, Japanese
• ミニサンプラーを用いた室内空気中可塑剤、難燃剤、殺虫剤等の一斉分析法
  斎藤 育江; 大貫 文; 矢口 久美子; 上原 眞一; 金澤 文子; 竹田 誠; 荒木 敦子; 岸 玲子, 環境ホルモン学会研究発表会要旨集, 10回, 75, 75, Dec. 2007
  環境ホルモン学会(日本内分泌撹乱化学物質学会), Japanese
• 新規シックハウス関連物質(MVOC)の測定法について
  竹田 誠; 河合 俊夫; 永滝 陽子; 荒木 敦子; 金澤 文子; 岸 玲子, 産業衛生学雑誌, 49, 6, 242, 243, Nov. 2007
  (公社)日本産業衛生学会, Japanese
• 一般住宅における微生物由来有機化合物(MVOC)測定法の確立と実態調査
  竹田 誠; 河合 俊夫; 永滝 陽子; 荒木 敦子; 金澤 文子; 岸 玲子, 産業衛生学雑誌, 80回CD-ROM抄録集, P3092, P3092, Apr. 2007
  (公社)日本産業衛生学会, Japanese
• 全国6地域の一般住民におけるシックハウス症候群の実態と原因の解明(第3報) 戸建住宅の室内環境要因と症状の地域差
  岸 玲子; 西條 泰明; 荒木 敦子; 田中 正敏; 柴田 英治; 森本 兼曩; 中山 邦夫; 瀧川 智子; 吉村 健清; 力 寿雄, 日本衛生学雑誌, 62, 2, 433, 433, Mar. 2007
  (一社)日本衛生学会, Japanese
• 札幌市一般住宅におけるフタル酸エステル、リン酸トリエステル、殺虫剤による室内汚染の実態
  金沢 文子; 斎藤 育江; 竹田 誠; 荒木 敦子; 馬 明月; 瀬戸 博; 岸 玲子, 日本衛生学雑誌, 62, 2, 435, 435, Mar. 2007
  (一社)日本衛生学会, Japanese

• プレコンセプションケア
  10 環境要因の生殖と次世代への影響 児への長期的影響
  メジカルビュー社, Apr. 2024, 9784758321402, [Contributor]
• 室内環境の事典 : 快適で健康な暮らしを支える科学
  室内環境学会, 5-16 シックハウス症候群（SHS） ［池田敦子］
  朝倉書店, Sep. 2023, 9784254266528, xiii, 439, 7p, 図版8p, Japanese, [Contributor]
• Indoor environmental quality and health risk toward healthier environment for all
  Kishi, Reiko; Norbäck, Dan; Araki, Atsuko
  Springer, 2020, 9789813291843, viii, 333 p., English

• Mixture Chemical Exposure in Utero and Boys Reproductive Hormone Levels at Birth: the Hokkaido Study
  Atsuko Araki; Chihiro Miyashita; Sachiko Itoh; Takahiko Mitsui; Houman Goudarzi; Kazutoshi Cho; Kimihiko Moriya; Tamie Nakajima; Yusuke Iwasaki; Tsuguhide Hori; Junboku Kajiwara; Nobuo Shinohara; Reiko Kish
  ISESISEE-AC2019, Nov. 2019, English, Oral presentation
  16 Nov. 2019 - 19 Nov. 2019
• The Hokkaido Study on Environment and Children’s Health: Overview of the study and collaborations with cohorts in Asia
  Atsuko Araki; Chihiro Miyashita; Machiko Minatoya; Reiko Kishi
  ISESISEE-AC2019, Nov. 2019, English, Public symposium
  16 Nov. 2019 - 19 Nov. 2019, [Invited]
• Capacity building and increasing awareness on environmental chemical exposures and prevention of their hazards
  Atsuko Araki; Machiko Minatoya; Reiko Kishi
  Pacific Basin Consortium Conference 2019, Sep. 2019, English, Invited oral presentation
  16 Sep. 2019 - 19 Sep. 2019, [Invited]
• Exposure to organophosphate esters in Japan: associations among their concentrations in house dust, urinary metabolite levels, and allergie
  Atsuko Araki; Yu Ait Bamai; Reiko Kishi
  ISESISIAQ-2019, Aug. 2019, English, Public symposium
  18 Aug. 2019 - 20 Aug. 2019
• Organohosphate flame retardants in house dust and their association with school children’s asthma and allergies
  Atsuko Araki; Yu Ait Bamai; Toshio kawai; Tazuru Tsuboi; Reiko Kishi
  ISEE/ES AC2018, 2018
  Taipei, Taiwan
• Mixed phthalate ester and phosphate flame retardant exposure and asthma and allergies in school children:
  Atsuko Araki; Yu Ait Bamai; Michiel Bastiaensen; Nele van den Eede; Toshio Kawai; Tazuru Tsuboi; Sachiko Itoh; Chihiro Miyashita; Adrian Covaci; Reiko Kishi
  ISESISEE-2018, 2018
  Ottawa, Canada
• ダイオキシン類の胎児期曝露による児のアレルギーへの影響 北海道スタディ
  宮下 ちひろ; 荒木 敦子; 伊藤 佐智子; 湊屋 街子; 小林 澄貴; アイツバマイ ゆふ; 梶原 淳睦; 戸高 尊; 岸 玲子
  日本衛生学雑誌, Mar. 2017, Japanese
• 胎児期BPA曝露による7歳までの喘鳴・アトピー性皮膚炎への影響 北海道スタディ
  アイツバマイ ゆふ; 宮下 ちひろ; 荒木 敦子; 湊屋 街子; 山本 潤; 松村 徹; 佐々木 成子; 岸 玲子
  日本衛生学雑誌, Mar. 2017, Japanese
• 住環境における健康リスク要因とそのマネジメント 室内環境中のハウスダストによる健康影響
  荒木 敦子; アイツバマイ ゆふ; 岸 玲子
  日本衛生学雑誌, Mar. 2017, Japanese
• 胎児期有機フッ素化合物曝露と臍帯血中アディポカイン濃度の関係 北海道スタディ
  湊屋 街子; 伊藤 佐智子; 宮下 ちひろ; 荒木 敦子; 佐々木 成子; 岩崎 雄介; 岸 玲子
  日本衛生学雑誌, Mar. 2017, English
• 住環境における健康リスク要因とそのマネジメント 科学的エビデンスに基づく「シックハウス症候群相談マニュアル改訂版」の作成について
  岸 玲子; 東 賢一; 西條 泰明; 柴田 英治; 田中 正敏; 河合 俊夫; 大和 浩; 吉野 博; 大澤 元毅; 増地 あゆみ; 荒木 敦子; アイツバマイ ゆふ; 湊屋 街子
  日本衛生学雑誌, Mar. 2017, Japanese
• Urinary biomonitoring of organophosphate flame retardants in Japanese children and correlations with house dust concentrations
  Bastiaensen M; Van den Eede N; Araki A; Ait Bamai Y; Kishi R; Covaci A
  Dioxin2017, 2017
  Vancouver, Canada
• Phthalates and organophosphate flame retardants in house dust and their relation to asllergies and oxidative stress marker 8-OHdG: the Hokkaido Study
  Atsuko Araki; Yu Ait Bamai; Toshio Kawai; Tzuru Tsuboi; Chihiro Miyashita; Reiko Kishi
  ISES2017, 2017
  Research Traiangle Park, NC, USA
• 室内環境中のハウスダストによる健康影響
  荒木敦子; アイツバマイゆふ; 岸玲子
  第87回日本衛生学会総会, 2017
  宮崎
• ヒトマクロファージ様THP-1細胞の遺伝子発現に及ぼすDEHP及びMEHPの曝露影響
  小島弘幸; 武内伸治; 室本竜太; 岸玲子; 荒木敦子
  第24回日本免疫毒性学会学術年会, 2017
  十和田市
• 「シックハウス症候群に関する相談マニュアル改訂新版」の作成 公衆衛生分野での活用に向けて
  荒木 敦子; アイツバマイ ゆふ; 西條 泰明; 湊屋 街子; 吉野 博; 東 賢一; 河合 俊夫; 大和 浩; 大澤 元毅; 柴田 英治; 田中 正敏; 増地 あゆみ; 岸 玲子
  北海道公衆衛生学雑誌, Oct. 2016, Japanese
• 胎児期の有機塩素系農薬曝露が母児の甲状腺ホルモンに及ぼす影響 北海道スタディ
  山崎 圭子; 宮下 ちひろ; 伊藤 佐智子; 荒木 敦子; 小林 祥子; 水谷 太; 苣木 洋一; 岸 玲子
  日本衛生学雑誌, May 2016, Japanese
• FLG変異とフタル酸エステル曝露による児のADへの影響 北海道スタディ
  アイツバマイ ゆふ; 荒木 敦子; 乃村 俊史; 河合 俊夫; 坪井 樹; 叢 石; 宮下 ちひろ; 池野 多美子; 清水 宏; 岸 玲子
  日本衛生学雑誌, May 2016, Japanese
• 母の喫煙曝露と胎児発育との関連 遺伝的なハイリスクについて 北海道スタディ
  小林 澄貴; 佐田 文宏; 佐々木 成子; Braimoh TitilolaSerifat; 荒木 敦子; 宮下 ちひろ; Goudarzi Houman; 小林 祥子; 岸 玲子
  日本衛生学雑誌, May 2016, Japanese
• DEHP曝露による胎生期ステロイドホルモンプロファイルへの影響 北海道スタディ
  荒木 敦子; グウダルジ・ホウマヌ; 三井 貴彦; 那須 民江; 宮下 ちひろ; 伊藤 佐智子; 佐々木 成子; 長 和俊; 野々村 克也; 岸 玲子
  日本衛生学雑誌, May 2016, Japanese
• ダイオキシン類異性体の曝露が胎生期の性ホルモンに与える影響 北海道スタディ
  宮下 ちひろ; 荒木 敦子; 三井 貴彦; 伊藤 佐知子; 佐々木 成子; 戸高 尊; 梶原 淳睦; 長 和俊; 野々村 克也; 岸 玲子
  日本衛生学雑誌, May 2016, Japanese
• 最近のDOHaD研究のトピックスと地域を基盤とする研究 環境省「子どもの健康と環境に関する全国調査(エコチル調査)」 北海道ユニットセンター・旭川サブユニットの参加者プロファイル
  西條 泰明; 川西 康之; 吉岡 英治; 伊藤 俊弘; 伊藤 善也; 伊藤 佐智子; 宮下 ちひろ; 荒木 敦子; 岸 玲子
  日本衛生学雑誌, May 2016, Japanese
• “Symposium-S2-09 Early life exposure to environmental endocrine disruptors and the related effects in children and adolescence” Prenatal Di(2-ethylhexyl) phthalate Exposure and Reproductive Hormone in Cord Blood ? The Hokkaido Study
  Atsuko Araki; Reiko Kishi
  ISEE-ISES AC2016, 2016
  Sapporo, Japan
• Prenatal exposure to organochlorine pesticides and reproductive hormones in fetal blood: The Hokkaido Study
  Atsuko Araki; Chihiro Miyashita; Sachiko Itoh; Takahiko Mitsui; Futoshi Mizutani; Yoichi Chisaki; Seiko Sasaki; Kazutoshi Cho; Katsuya Nonomura; Reiko Kishi
  ISEE2016, 2016
  Rome, Italy
• Prenatal exposure to organochlorine pesticides and steroid hormones profiles in fetal blood-the Hokkaido Study
  tsuko Araki; Chihiro Miyashita; Takahiko Mitsui; Houman Goudarzi; Sachiko Itoh; Futoshi Mizutani; Youichi Chisaki; Seiko Sasaki; Kimihiko Moriya; Kazutoshi Cho; Nobuo Shinohara; Katsuya Nonomura; Reiko Kishi
  PPToX V, 2016
  Kitakyusyu, Japan
• Association between prenatal phthalates and BPA exposures and fatal adipokines and birth size: the Hokkaido Study on Environment and Children’s Health
  Machiko Minatoya; Atsuko Araki; Chihiro Miyashita; Jun Yamamoto; Yu Onoda; Toru Matsumura; Reiko Kishi
  PPToX V, 2016
  Kitakyusyu, Japan
• 産業衛生の現場で役立つ「シックハウス症候群に関する相談マニュアル改訂新版」の作成
  荒木敦子; 西條泰明; アイツバマイゆふ; 湊屋街子; 吉野博; 東賢一; 河合俊夫; 大和浩; 大澤元毅; 柴田英治; 田中正敏; 増地あゆみ; 岸玲子
  第96回 北海道医学大会 産業衛生分科会, 2016
  札幌
• シックハウス症候群に関する相談マニュアル改訂新版」の作成‐公衆衛生分野での活用に向けて‐
  荒木敦子; アイツバマイゆふ; 西條泰明; 湊屋街子; 吉野博; 東賢一; 河合俊夫; 大和浩; 大澤元毅; 柴田英治; 田中正敏; 増地あゆみ; 岸玲子
  第68回 北海道公衆衛生学会, 2016
  札幌
• エコチル調査北海道ユニットセンター旭川サブユニット参加者における母体基本属性および周産期転帰と、その全国データとの比較
  川西 康之; 西條 泰明; 伊藤 善也; 中木 良彦; 吉岡 英治; 伊藤 俊弘; 吉田 貴彦; 宮本 敏伸; 千石 一雄; 東 寛; 土川 陽子; 宮下 ちひろ; 荒木 敦子; 岸 玲子
  北海道公衆衛生学雑誌, Nov. 2015, Japanese
• 北海道のエコチル調査の集計結果 生後2歳までの食物アレルギーの頻度および食品の摂食状況について
  アイツバマイ ゆふ; 西條 泰明; 伊藤 善也; 村林 宏; 吉岡 英治; 川西 康之; 水上 尚典; 有賀 正; 長和 俊; 白石 秀明; 千石 一雄; 宮本 敏伸; 東 寛; 堤 裕幸; 遠藤 俊明; 馬場 剛; 小林 正樹; 荒木 敦子; 池野 多美子; 宮下 ちひろ; 伊藤 佐智子; 土川 陽子; 湊屋 街子; 小林 澄貴; 山崎 圭子; 西原 進吉; 田村 菜穂美; 岸 玲子
  北海道公衆衛生学雑誌, Nov. 2015, Japanese
• 胎児期ビスフェノールA曝露による臍帯血中のアディポカイン、出生体重、子どもの体重への影響 北海道スタディ
  湊屋 街子; 佐々木 成子; 荒木 敦子; 宮下 ちひろ; 山本 潤; 松村 徹; 岸 玲子
  北海道公衆衛生学雑誌, Nov. 2015, Japanese
• 胎児期ダイオキシン類曝露による臍帯血中性ホルモンへの影響 環境と子供の健康北海道スタディ
  宮下 ちひろ; 荒木 敦子; 三井 貴彦; 伊藤 佐知子; 佐々木 成子; 戸高 尊; 梶原 淳睦; 長和 俊; 野々村 克也; 岸 玲子
  北海道公衆衛生学雑誌, Nov. 2015, Japanese
• 妊娠初期における就労女性の有害物質の取扱いが児の流・死産に及ぼす影響
  小林 澄貴; 宮下 ちひろ; 荒木 敦子; 池野 多美子; 伊藤 佐智子; Goudarzi Houman; 花岡 知之; 岸 玲子
  北海道公衆衛生学雑誌, Nov. 2015, Japanese
• 母体への環境化学物質曝露と胎児期ホルモン環境が身体的変化に与える影響 第2指/第4指比との関連性について
  三井 貴彦; 荒木 敦子; 宮下 ちひろ; 橘田 岳也; 守屋 仁彦; 長 和俊; 森岡 圭太; 伊藤 佐智子; 篠原 信雄; 岸 玲子; 野々村 克也
  日本生殖医学会雑誌, Jul. 2015, Japanese
• 胎児期における男性ホルモンへの曝露が小児期の脳の性分化に与える影響について
  三井 貴彦; 荒木 敦子; 伊藤 佐智子; 宮下 ちひろ; 橘田 岳也; 守屋 仁彦; 長 和俊; 森岡 圭太; 篠原 信雄; 岸 玲子; 野々村 克也
  泌尿器外科, May 2015, Japanese
• マタニティヨガの周産期予後改善効果に関する研究
  川西 康之; 中木 良彦; 伊藤 俊弘; 吉岡 英治; 吉田 貴彦; 伊藤 善也; 宮下 ちひろ; 荒木 敦子; 岸 玲子; 千石 一雄; 西條 泰明
  北海道産科婦人科学会会誌, Mar. 2015, Japanese
• 第2指・第4指比(2D/4D比)に影響を及ぼす遺伝要因の検討
  佐田 文宏; 江藤 亜紀子; 金谷 泰宏; 三井 貴彦; 荒木 敦子; 岸 玲子; 野々村 克也
  日本衛生学雑誌, Mar. 2015, Japanese
• 児の出生体重と母親の社会経済要因との関連についての疫学研究 北海道スタディ
  田村 菜穂美; 伊藤 久美子; 花岡 知之; 喜多 歳子; 西原 進吉; 宮下 ちひろ; 荒木 敦子; 小笠原 克彦; 岸 玲子
  日本衛生学雑誌, Mar. 2015, Japanese
• 胎児期の有機塩素系農薬曝露が6ヵ月児の精神運動発達に及ぼす影響 北海道スタディ
  山崎 圭子; 宮下 ちひろ; 中島 そのみ; 池野 多美子; 荒木 敦子; 伊藤 佐智子; 小林 祥子; 水谷 太; 苣木 洋一; 岸 玲子
  日本衛生学雑誌, Mar. 2015, Japanese
• 有機塩素系農薬が乳幼児の免疫に与える影響 環境と子どもの健康北海道スタディー
  宮下 ちひろ; 金澤 文子; 佐々木 成子; 池野 多美子; 荒木 敦子; 伊藤 佐智子; 小林 祥子; 水谷 太; 苣木 洋一; 岸 玲子
  日本衛生学雑誌, Mar. 2015, Japanese
• 有機塩素系農薬への胎児期曝露による児の性ホルモン濃度への影響 北海道スタディ
  荒木 敦子; 宮下 ちひろ; 金澤 文子; 伊藤 佐智子; 三井 貴彦; 佐々木 成子; 水谷 太; 苣木 洋一; 野々村 克也; 岸 玲子
  日本衛生学雑誌, Mar. 2015, Japanese
• 胎児期MEHP曝露による神経行動発達への影響 北海道スタディ
  湊屋 街子; 佐々木 成子; 中島 そのみ; 那須 民江; 後藤 裕子; 宮下 ちひろ; 荒木 敦子; 小林 澄貴; 池野 多美子; 岸 玲子
  日本衛生学雑誌, Mar. 2015, Japanese
• ダイオキシン類曝露と胎児発育との関連 遺伝的なリスクについて 北海道スタディ
  小林 澄貴; 宮下 ちひろ; 佐々木 成子; 荒木 敦子; 佐田 文宏; 坂 晋; 梶原 淳睦; 戸高 尊; 岸 玲子
  日本衛生学雑誌, Mar. 2015, Japanese
• 臍帯血ビスフェノールA濃度と児のIGF2 DNAメチル化との関連 北海道スタディ
  小林 祥子; 安住 薫; 佐々木 成子; 松村 徹; 山本 潤; 石塚 真由美; 宮下 ちひろ; 池野 多美子; 荒木 敦子; 岸 玲子
  日本衛生学雑誌, Mar. 2015, Japanese
• 北海道スタディ出生コホートを用いたアレルギー疾患とフィラグリン遺伝子変異の関連解析
  乃村 俊史; 竹田 真依; 鈴木 翔多朗; 清水 宏; 荒木 敦子; 宮下 ちひろ; 池野 多美子; 佐々木 成子; 岸 玲子; 秋山 真志
  角化症研究会記録集, Mar. 2015, Japanese
• “Symposium-S17-Phthalate Diester Exposure and Systematic Health Effects” Allergic disease in relation to phthalates in house dust and urine
  Atsuko Araki; Yu Ait Bamai; Reiko Kishi
  ISEE2015, 2015
  Sao Paolo, Brazil
• 胎児期ビスフェノールA曝露影響に関する臍帯血DNA網羅的メチル化解析??北海道スタディ
  第4回日本DOHaD研究学術集会, 2015
  東京
• 北海道3地区における妊婦の食習慣・運動習慣の実態について 環境省「子どもの健康と環境に関する全国調査(エコチル調査)」 北海道ユニットセンター登録者のデータから
  湊屋 街子; 西條 泰明; 伊藤 善也; 荒木 敦子; 池野 多美子; 宮下 ちひろ; 伊藤 佐智子; 小林 澄貴; 土川 陽子; 田村 菜穂美; 吉岡 英治; 川西 康之; 村林 宏; 岸 玲子; エコチル調査北海道ユニットセンター事務局
  北海道公衆衛生学雑誌, Dec. 2014, Japanese
• 胎児期の母の受動喫煙が児の出生時体格に及ぼす影響 遺伝環境交互作用について
  小林 澄貴; 佐々木 成子; 佐田 文宏; 宮下 ちひろ; 池野 多美子; 荒木 敦子; 岸 玲子
  北海道公衆衛生学雑誌, Dec. 2014, Japanese
• 胎児期の有機塩素系農薬が小児アレルギー発症に与える影響 環境と子どもの健康北海道スタディ
  宮下 ちひろ; 金澤 文子; 池野 多美子; 荒木 敦子; 伊藤 佐智子; 小林 澄貴; 湊屋 街子; Goudarzi Houman; 小林 祥子; 田村 菜穂美; 水谷 太; 苣木 洋一; 岸 玲子
  北海道公衆衛生学雑誌, Dec. 2014, Japanese
• さい帯血と血液のダイオキシン及びPCB類の組成比較
  梶原 淳睦; 戸高 尊; 平川 博仙; 宮下 ちひろ; 伊藤 佐智子; 佐々木 成子; 荒木 敦子; 岸 礼子
  環境ホルモン学会研究発表会要旨集, Dec. 2014, Japanese
• 環境省「エコチル調査」北海道ユニットセンターにおけるこれまでの活動報告
  荒木 敦子; 伊藤 善也; 西條 泰明; 池野 多美子; 宮下 ちひろ; 伊藤 佐智子; 土川 陽子; 田村 菜穂美; 湊屋 街子; 吉岡 英治; 川西 康之; 村林 宏; 岸 玲子
  環境ホルモン学会研究発表会要旨集, Dec. 2014, Japanese
• 胎児期ビスフェノールA曝露による臍帯血中性ホルモン濃度への影響
  佐々木 成子; 山本 潤; 荒木 敦子; 伊藤 佐智子; 宮下 ちひろ; 三井 貴彦; 長 和俊; 野々村 克也; 松村 徹; 岸 玲子
  日本衛生学雑誌, May 2014, Japanese
• DEHPへの胎児期曝露による児の性ホルモン濃度への影響
  荒木 敦子; 三井 貴彦; 宮下 ちひろ; 那須 民江; 伊藤 佐智子; 佐々木 成子; 長 和俊; 池野 多美子; 野々村 克也; 岸 玲子
  日本衛生学雑誌, May 2014, Japanese
• 児の出生体重と母親の社会経済要因との関連についての疫学研究
  田村 菜穂美; 伊藤 久美子; 小林 澄貴; 岡田 恵美子; 喜多 歳子; ホウマヌ・ゴウダルジ; 宮下 ちひろ; 荒木 敦子; 池野 多美子; 岸 玲子
  日本衛生学雑誌, May 2014, Japanese
• PFOS・PFOAの胎児期曝露が与える児の出生時性ホルモン濃度への影響
  伊藤 佐智子; 荒木 敦子; 宮下 ちひろ; 中澤 裕之; 三井 貴彦; 長 和俊; 佐々木 成子; 池野 多美子; 野々村 克也; 岸 玲子
  日本衛生学雑誌, May 2014, Japanese
• 生殖次世代影響の疫学研究における生体内短半減期物質の評価 フタル酸エステル類の胎児期曝露による次世代影響に関する疫学研究
  荒木 敦子; 岸 玲子
  日本衛生学雑誌, May 2014, Japanese
• 母体への環境化学物質曝露と胎児期ホルモン環境が身体的変化に与える影響 第2指/第4指比との関連性について
  三井 貴彦; 荒木 敦子; 宮下 ちひろ; 今井 紋子; 佐藤 早基子; 橘田 岳也; 守屋 仁彦; 長 和俊; 森岡 圭太; 伊藤 佐智子; 岸 玲子; 野々村 克也
  日本泌尿器科学会総会, Apr. 2014, Japanese
• Association between Maternal Exposure to Di(2-Ethylhexyl) Phthalate and Sex Hormone Levels in Fetal Blood
  Atsuko Araki; Takahiko Mitsui; Chihiro Miyashita; Tamie Nakajima; Seiko Sasaki; Tamiko Ikeno; Kazutoshi Cho; Sachiko Ito; Katsuya Nonomura; Reiko Kishi
  ISEE2014, 2014
  Seattle, WA, USA
• Effect of PFOS and PFOA Exposure in Utero on Reproductive Hormones Levels at Birth
  Sachiko Itoh; Atsuko Araki; Chihiro Miyashita; Hiroyuki Nakazawa; Takahiko Mitsui; Kazutoshi Cho; Seiko Sasaki; Tamiko Ikeno; Katsuya Nonomura; Reiko Kishi
  ISEE2014, 2014
  Seattle, WA, USA
• Exposure to House Dust Phthalates in Relation to Asthma and Allergies in Both Children and Adults
  Yu Ait Bamai; Eiji Shibata; Ikue Saito; Atsuko Araki; Ayako Kanazawa; Kanehisa Morimoto; Kunio Nakayama; Masatoshi Tanaka; Tomoko Takigawa; Kanesumi Yoshimura; Hisao Chikara; Yasuaki Saijo; Reiko Kishi
  ISEE2014, 2014
  Seattle, WA, USA
• Exposure to Perfluoroalkyl Chemicals and Neurodevelopment at 6 Months of Age
  Houman Goudarzi; Tamiko Ikeno; Sachiko Kobayashi; Atsuko Araki; Chihiro Miyashita; Seiko Sasaki; Sonomi Nakajima; Hiroyuki Nakazawa; Reiko Kish
  ISEE2014, 2014
  Seattle, WA, USA
• The Effects of Perfluoroalkyl Acids (Pfaas) Exposure in Utero on IGF2/H19 DNA Methylation in Cord Blood
  Sachiko Kobayashi; Kaoru Azumi; Seiko Sasaki; Mayumi Ishizuka; Hiroyuki Nakazawa; Emiko Okada; Sumitaka Kobayashi; Houman Goudarzi; Sachiko Itoh; Chihiro Miyashita; Tamiko Ikeno; Atsuko Araki; Reiko Kishi
  ISEE2014, 2014
  Seattle, WA, USA
• Perinatal PFAAs Exposure Cause Various Health Outcomes on Offspring Including Effects on Reproductive and Thyroid Hormones: The Hokkaido Study
  Reiko Kishi; Atsuko Araki; Sachiko Itoh; Chihiro Miyashita; Houman Goudarzi; Sachiko Kobayashi; Seiko Sasaki; Ikuko Kashino; H Nakazawa; Tamie Nakajima; Takahiko Mitsui; Katsuya Nonomura
  PPToX IV, 2014
  Boston, MA, USA
• Hokkaido Study on Environment and Children’s Health: Cohort profile and findings of perinatal Perfluoroalkyl acid (PFAAs)exposure and various health outcomes
  Reiko Kishi; Atsuko Araki
  ISEE-AC2014, 2014
  Shanghai, Chaina
• Prenatal bisphenol A exposure and birth outcomes: The Hokkaido Study
  Machiko Minatoya; Seiko Sasaki; Sonomi Nakajima; Jun Yamamoto; Atsuko Araki; Sachiko Itoh; Chihiro Miyashita; Toru Matsumura; Katsuya Nonomura; Takahiko Mitsui; Kazutoshi Cho; Reiko Kishi
  ISEE-AC2014, 2014
  Shanghai, Chaina
• 胎児のホルモン環境に影響を及ぼす要因の検討 ホルモン関連遺伝子多型と臍帯血ホルモン濃度
  佐田 文宏; 江藤 亜紀子; 荒木 敦子; 三井 貴彦; 金谷 泰宏; 岸 玲子; 野々村 克也
  環境ホルモン学会研究発表会要旨集, Dec. 2013, Japanese
• 北海道3地区における妊婦の喫煙率および喫煙開始年齢について 環境省「子どもの環境と健康に関する全国調査(エコチル調査)」より
  荒木 敦子; 西條 泰明; 伊藤 善也; 池野 多美子; 宮下 ちひろ; 伊藤 佐智子; 土川 陽子; 吉岡 英治; 川西 康之; 村林 宏; 岸 玲子
  北海道公衆衛生学雑誌, Nov. 2013, Japanese
• 尿中フタル酸代謝物濃度とハウスダスト中フタル酸エステル濃度との関連 札幌市児童における調査
  アイツバマイ ゆふ; 荒木 敦子; 河合 俊夫; 坪井 樹; 多島 秀司; 叢 石; 湯浅 資之; 金澤 文子; 玉腰 暁子; 岸 玲子
  北海道公衆衛生学雑誌, Nov. 2013, Japanese
• 札幌市内小学生の自宅における暖房、および機械換気の有無と児童の喘息
  叢 石; 荒木 敦子; 鵜川 重和; アイツバマイ ゆふ; 多島 秀司; 金澤 文子; 湯浅 資之; 玉腰 暁子; 岸 玲子
  北海道公衆衛生学雑誌, Nov. 2013, Japanese
• 札幌市128軒のハウスダスト中リン酸トリエステル類濃度と小学生のアレルギー疾患との関連
  多島 秀司; 荒木 敦子; 河合 俊夫; 坪井 樹; アイツバマイ ゆふ; 叢 石; 吉岡 英治; 岸 玲子
  北海道公衆衛生学雑誌, Nov. 2013, Japanese
• マタニティヨガの周産期予後改善効果に関する研究(エコチル調査北海道追加調査)
  川西 康之; 中木 良彦; 伊藤 俊弘; 吉岡 英治; 吉田 貴彦; 伊藤 善也; 池野 多美子; 荒木 敦子; 岸 玲子; 西條 泰明
  日本公衆衛生学会総会抄録集, Oct. 2013, Japanese
• マタニティヨガの周産期予後改善効果に関する研究
  川西 康之; 中木 良彦; 伊藤 俊弘; 吉岡 英治; 吉田 貴彦; 伊藤 善也; 宮下 ちひろ; 荒木 敦子; 岸 玲子; 千石 一雄; 西條 泰明
  北日本産科婦人科学会総会・学術講演会プログラム・抄録集, Sep. 2013, Japanese
• GC/MSによるヒトの尿中2-エチルヘキサノールの定量 フタル酸ジエステル類評価としての無水フタル酸可塑剤・難燃剤曝露と小児の健康影響
  河合 俊夫; 坪井 樹; 荒木 敦子; アイツバマイ ゆふ; 岸 玲子
  産業衛生学雑誌, May 2013, Japanese
• 児童の尿中フタル酸代謝物濃度とアレルギー 可塑剤、難燃剤の小児への健康影響(4)
  荒木 敦子; 坪井 樹; 河合 俊夫; アイツバマイ ゆふ; 多島 秀司; 叢 石; 鵜川 重一; 吉岡 英治; 岸 玲子
  日本衛生学雑誌, Mar. 2013, Japanese
• フタル酸ジエステル類評価としての無水フタル酸可塑剤・難燃剤曝露と小児の健康影響(2)
  河合 俊夫; 坪井 樹; 荒木 敦子; アイツバマイ ゆふ; 岸 玲子
  日本衛生学雑誌, Mar. 2013, Japanese
• アレルギーとダスト中フタル酸エステル濃度 可塑剤・難燃剤曝露と小児の健康影響(3)
  アイツバマイ ゆふ; 荒木 敦子; 坪井 樹; 河合 俊夫; 多島 秀司; 叢 石; 吉岡 英治; 玉腰 暁子; 岸 玲子
  日本衛生学雑誌, Mar. 2013, Japanese
• フタル酸エステル尿中代謝物の同時測定方法の開発可塑剤難燃剤曝露と小児の健康影響(1)
  坪井 樹; 河合 俊夫; 荒木 敦子; アイツバマイ ゆふ; 岸 玲子
  日本衛生学雑誌, Mar. 2013, Japanese
• Phthalate metabolites in urine and their relation to allergies in school children -Exposure assessment to plasticizer and flame retardants (3)-
  Atsuko Araki; Toshio Kawai; Tazuru Tsuboi; Yu Ait Bamai; Eiji Yoshioka; Shuji Tajima; Cong Shi; Shigekazu Ukawa; Reiko Kishi
  ISEE-ISES-ISIAQ 2013, 2013
  Basel, Switzerland
• Biological monitoring of environments exposure to DEHP by urine analysis for 2-Ethyl-1-hexanol. Environment and Health - Bridging South, North, East and West Conference of ISEE, ISES and ISIAQ. Basel, Switzerland.
  Kawai Toshio; Tsuboi Tazuru; Araki Atsuko; Bamai Ait Yu; Kishi Reiko
  ISEE-ISES-ISIAQ 2013, 2013
  Basel, Switzerland
• Maternal exposure to DEHP and sex hormone levels in cord blood
  Atsuko Araki; Takahiko Mitsui; Chihiro Miyashita; Masahiro Tagawa; Tamie Nakajima; Seiko Sasaki; Tamiko Ikeno; Sachiko Itoh; Emiko Okada; Kazutoshi Cho; Katsuya Nonomura; Reiko Kishi
  DOHaD2013, 2013
  Singapore
• 可塑剤・難燃剤の曝露評価手法の開発と小児アレルギー・リスク評価への応用 尿中2-エチル-1-ヘキサノールの分析方法と測定事例
  河合 俊夫; 坪井 樹; 荒木 敦子; アイツバマイゆふ; 岸 玲子
  産業衛生学雑誌, Jan. 2013, Japanese
• 環境省「エコチル調査」に関する意識調査と広報活動の課題
  荒木 敦子; 尾西 奈江; 中瀬 督久; 岸 玲子; エコチル調査北海道ユニットセンター事務局
  北海道公衆衛生学雑誌, Nov. 2012, Japanese
• ハウスダスト中に含まれるリン酸トリエステル類の濃度と住居環境
  多島 秀司; 荒木 敦子; 坪井 樹; 河合 俊夫; 斎藤 育江; アイツバマイ ゆふ; 竹田 智哉; 鵜川 重和; 吉岡 英治; 岸 玲子
  北海道公衆衛生学雑誌, Nov. 2012, Japanese
• 小学生の住宅におけるハウスダスト中のエンドトキシンならびにβ-グルカン量とアレルギー性疾患に関する研究
  叢 石; 荒木 敦子; アイツバマイ ゆふ; 竹田 智哉; 早川 敦司; 吉岡 英治; 多島 秀司; 鵜川 重和; 玉腰 暁子; 岸 玲子
  北海道公衆衛生学雑誌, Nov. 2012, Japanese
• 札幌市の小学生4500名を対象とした住環境と喘息、アトピー性皮膚炎に関する調査
  鵜川 重和; 荒木 敦子; 金澤 文子; 湯浅 資之; 吉岡 英治; 岸 玲子
  日本公衆衛生学会総会抄録集, Oct. 2012, Japanese
• ヒトの出産前後における血液DEHP代謝物濃度の解析
  田川 雅大; 内藤 久雄; 林 由美; 川野 愛子; 佐々木 成子; 荒木 敦子; 小林 澄貴; 岸 玲子
  日本衛生学雑誌, Feb. 2012, Japanese
• 小学生のシックハウス症候群の有訴と床ダスト中有機リン酸トリエステル類濃度との関係
  多島 秀司; 荒木 敦子; 斎藤 育江; 河合 俊夫; 坪井 樹; アイツバマイ ゆふ; 竹田 智哉; 吉岡 英治; 鵜川 重和; 岸 玲子
  日本衛生学雑誌, Feb. 2012, Japanese
• 札幌市小学生の喘息・鼻結膜炎有訴と自宅環境および気中VOC・MVOC濃度
  荒木 敦子; アイツバマイ ゆふ; 河合 俊夫; 坪井 樹; 竹田 智哉; 多島 秀司; 鵜川 重和; 叢 石; 吉岡 英治; 岸 玲子
  日本衛生学雑誌, Feb. 2012, Japanese
• シックハウス症候群研究最近の動向 シックハウス症候群に関する全国規模の疫学研究 化学物質、湿度環境、生物学的要因
  荒木 敦子; 西條 泰明; 田中 正敏; 瀧川 智子; 吉村 健清; 森本 兼曩; 柴田 英治; 河合 俊夫; 斎藤 育江; 岸 玲子
  日本衛生学雑誌, Feb. 2012, Japanese
• Phthalate in house dust and tis relation to sick building syndrome and allergic symptoms.
  Reiko Kishi; Atsuko Araki; Ikue Saito; Eiji Shibata; Ayako Kanazawa; Kanehisa Morimoto; Kunio Nakayama; Masatoshi Tanaka; Tomoko Takigawa; Takesumi Yoshimura; Hisao Chikara; Yasuaki Saijo
  ICOH2012, 2012
  Cancun, Mexico
• Determination of phthalate metabolites in urine of children and their family -Exposure assessment to plasticizer and flame retardants and their risk on children (3)-
  Atsuko Araki; Toshio Kawai; Tazuru Tsuboi; Yu Ait Bamai; Tomoya Takeda; Eiji Yoshioka; Shuji Tajima; Shigekazu Ukawa; Cong Shi; Reiko Kishi
  ISES2012, 2012
  Seattle, WA, USA
• Determination of human urinary metabolites of five phthalate by gas chromatography-mass spectrometry -Exposure assessment to plastisizer and flame retardants and their risk on children (1)-
  Tsuboi Tazuru; Toshio Kawai; Atsuko Araki; Yu Ait Bamai; Reiko Kishi
  ISES2012, 2012
  Seattle, WA, USA
• Phthalic anhydride as a marker of total uptake of phthalate diesters -Exposure assessment to plastisizer and flame retardants and their risk on children (2)-
  Toshio Kawai; Tsuboi Tazuru; Atsuko Araki; Yu Ait Bamai; Reiko Kishi
  ISES2012, 2012
  Seattle, WA, USA
• Research plan for 7 year-old survey of the Hokkaido Stud
  Atsuko Araki; Chihiro Miyashita; Tamiko Ikeno; Seiko Sasaki; Shuji Tajima; Yu Ait Bamai; Cong Shi; Shigekazu Ukawa; Toshio Kawai; Tazuru Tsuboi; Emiko Okada; Reiko Kishi
  BiCCA2012, 2012
  Taipei, Taiwan
• 小学生の住宅におけるハウスダスト中のエンドトキシンならびにβ-グルカン量と住宅特徴に関する調査
  叢 石; 荒木 敦子; アイツバマイ ゆふ; 竹田 智哉; 早川 敦司; 吉岡 英治; 多島 秀司; 鵜川 重和; 岸 玲子
  北海道公衆衛生学雑誌, Nov. 2011, Japanese
• 自宅住環境とアトピー性皮膚炎に関する調査 札幌市の小学生4,500名を対象として
  鵜川 重和; 荒木 敦子; 金澤 文子; 湯浅 資之; アイツバマイ ゆふ; 吉岡 英治; 叢 石; 多島 秀司; 岸 玲子
  北海道公衆衛生学雑誌, Nov. 2011, Japanese
• 自宅空気中化学物質濃度とシックハウス症候群に関する調査研究 札幌市小学生を対象として
  荒木 敦子; アイツバマイ ゆふ; 坪井 樹; 河合 俊夫; 竹田 智哉; 早川 敦司; 吉岡 英治; 多島 秀司; 叢 石; 鵜川 重和; 岸 玲子
  北海道公衆衛生学雑誌, Nov. 2011, Japanese
• Variations of Indoor Environment and the Prevalence of Sick House Syndrome over Three-Year Period in Detached Houses in Sapporo
  ARAKI Atsuko; KANAZAWA Ayako; SAIJO Yasuaki; KISHI Reiko
  Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene), 15 May 2011, Japanese
  Objectives: The purpose of this study was to investigate annual variations in indoor environmental chemical, fungal and dust mite allergen levels, with regards to variations in sick house syndrome (SHS) symptoms over a three-year period. Methods: Detached houses were randomly selected from a building plan approval application, and a questionnaire survey was conducted in 2003 in Sapporo, Japan. Indoor environmental measurements and a self-administered questionnaires survey were conducted on the selected houses in 2004, 2005 and 2006. The same protocol was used for the three-year period to me...
• シックハウス症状解明のための超小型、軽量、拡散型サンプラーの開発 アルデヒド測定用サンプラー
  河合 俊夫; 坪井 樹; 乾谷 正樹; 荒木 敦子; 住野 公昭; 岸 玲子
  産業衛生学雑誌, May 2011, Japanese
• シックハウス症状解明のための超小型、軽量、拡散型サンプラーの開発 VOC測定用サンプラー
  坪井 樹; 河合 俊夫; 乾谷 正樹; 住野 公昭; 荒木 敦子; 岸 玲子
  産業衛生学雑誌, May 2011, Japanese
• 札幌市小学生のシックハウス症候群有訴と自宅の気中化学物質濃度
  荒木 敦子; アイトバマイ ゆふ; 竹田 智哉; 河合 俊夫; 坪井 樹; 早川 敦司; 吉岡 英治; 岸 玲子
  日本衛生学雑誌, Feb. 2011, Japanese
• 微生物由来VOCによる室内空気室汚染の実情と健康影響
  荒木 敦子; 岸 玲子
  日本衛生学雑誌, Feb. 2011, Japanese
• Organophosphate triesters in house dust and its relation to allergic symptoms.
  Atsuko Araki; Tomoya Takeda; Ayako Kanazawa; Ikue Saito; Kanehisa Morimoto; Kunio Nakayama; Eiji Shibata; Masatoshi Tanaka; Tomoko Takigawa; Takesumi Yoshimura; Hisao Chikara; Yasuaki Saijo; Reiko Kishi
  ISEE2011, 2011
  Barcelona, Spain
• Validation and feasibility study of the developed small diffusive sampers for aldehyde and VOC in elementary school children
  Atsuko Araki; Toshio Kawai; Tazuru Tsuboi; Yu Ait Bamai; Tomoya Takeda; Eiji Yoshioka; Reiko Kishi
  7th AIRMON, 2011
  Loen, Norway
• 室内環境汚染物質51物質の分析・測定技術
  坪井 樹; 永滝 陽子; 河合 俊夫; 住野 公昭; 荒木 敦子; 大前 和幸; 岸 玲子
  産業衛生学雑誌, May 2010, Japanese
• 喫煙者の有無別にみた室内環境化学物質濃度とシックハウス症候群の自覚症状
  アイトバマイ ゆふ; 荒木 敦子; 西條 泰明; 森本 兼曩; 中山 邦夫; 瀧川 智子; 田中 正敏; 柴田 英治; 吉村 健清; 力 寿雄
  日本衛生学雑誌, Apr. 2010, Japanese
• Prevalence of asthma, atopic dermatitis, and rhinitis and MVOC exposure in single family homes ?a survey in six cities of Japan-
  Atsuko Araki; Toshio Kawai; Yoko Eitaki; Ayako Kanazawa; Kanehisa Morimoto; Kunio Nakayama; Eiji Shibata; Masatoshi Tanaka; Tomoko Takigawa; Takesumi Yoshimura; Hisashi Chikara; Yasuaki Saijo; Reiko Kishi
  ISEE-ISES 2010, 2010
  Seoul, Korea
• シックハウス関連物質の活性炭脱着率に関する基礎的検討
  永滝 陽子; 坪井 樹; 河合 俊夫; 清水 英佑; 大前 和幸; 荒木 敦子; 岸 玲子
  産業衛生学雑誌, Jan. 2010, Japanese
• 札幌市小学生を対象としたシックハウス症候群の有訴率と関連要因に関する調査
  荒木 敦子; 湯浅 資之; 金澤 文子; 岸 玲子
  北海道公衆衛生学雑誌, Nov. 2009, Japanese
• 全国6地域の一般住宅におけるシックハウス症候群の実態と原因の解明 (第5報)室内空気質中Microbial VOC類の濃度と症状との関係
  荒木 敦子; 河合 俊夫; 永滝 陽子; 金澤 文子; 竹田 誠; 森本 兼曩; 中山 邦夫; 柴田 英治; 田中 正敏; 瀧川 智子; 吉村 健清; 力 寿雄; 岸 玲子
  日本衛生学雑誌, Mar. 2009, Japanese
• 札幌市新築戸建住宅における3年間の室内環境変化
  荒木 敦子; 金澤 文子; 竹田 誠; 西條 泰明; 岸 玲子
  北海道公衆衛生学雑誌, Nov. 2008, Japanese
• 全国6地域の一般住宅におけるシックハウス症候群の実態と原因の解明 : 第4報 室内空気質中 Microbial VOC 類の濃度と住環境との関係
  荒木 敦子; 河合 俊夫; 永滝 陽子; 竹田 誠; 金澤 文子; 森本 兼曩; 中山 邦夫; 柴田 英治; 田中 正敏; 瀧川 智子; 吉村 健清; 力 寿雄; 岸 玲子
  日本衞生學雜誌, 01 Mar. 2008, Japanese
• 札幌市一般住宅におけるフタル酸エステル、リン酸トリエステルによる室内汚染 : 実態解明とシックハウス症候群との関連
  金澤 文子; 斎藤 育江; 荒木 敦子; 竹田 誠; 矢口 久美子; 岸 玲子
  日本衞生學雜誌, 01 Mar. 2008, Japanese
• Aromatherapy massage benefit patient with idiopathic environmental intolerance in short term mood changes: A pilot study.
  Atsuko Araki; Kazuhiko Watanabe; Yoko Eitaki; Toshio Kawai; Reiko Kishi
  10th International Congress of Behavioral Medicine, 2008
  Tokyo, Japan
• ミニサンプラーを用いた室内空気中可塑剤、難燃剤、殺虫剤等の一斉分析法
  斎藤 育江; 大貫 文; 矢口 久美子; 上原 眞一; 金澤 文子; 竹田 誠; 荒木 敦子; 岸 玲子
  環境ホルモン学会研究発表会要旨集, Dec. 2007, Japanese
• 8.新規シックハウス関連物質(MVOC)の測定法について(一般口演,第34回有機溶剤中毒研究会,地方会・研究会記録)
  竹田 誠; 河合 俊夫; 永滝 陽子; 荒木 敦子; 金澤 文子; 岸 玲子
  産業衛生学雑誌, 20 Nov. 2007, Japanese
• 新規シックハウス関連物質(MVOC)の測定法について
  竹田 誠; 河合 俊夫; 永滝 陽子; 荒木 敦子; 金澤 文子; 岸 玲子
  産業衛生学雑誌, Nov. 2007, Japanese
• 一般住宅における微生物由来有機化合物(MVOC)測定法の確立と実態調査
  竹田 誠; 河合 俊夫; 永滝 陽子; 荒木 敦子; 金澤 文子; 岸 玲子
  産業衛生学雑誌, Apr. 2007, Japanese
• 全国6地域の一般住民におけるシックハウス症候群の実態と原因の解明(第3報) 戸建住宅の室内環境要因と症状の地域差
  岸 玲子; 西條 泰明; 荒木 敦子; 田中 正敏; 柴田 英治; 森本 兼曩; 中山 邦夫; 瀧川 智子; 吉村 健清; 力 寿雄
  日本衛生学雑誌, Mar. 2007, Japanese
• A study on sick house syndrome in Japanese general dwellings : Part 3- Regional differences of symptom prevalence and indoor environmental factors
  ARAKI Atsuko
  日本衞生學雜誌, 01 Mar. 2007, Japanese
• Indoor contamination with phthalate esters, organophosphate esters, and pesticides in air and dust in residential houses in Sapporo
  KANAZAWA Ayako
  日本衞生學雜誌, 01 Mar. 2007, Japanese

• 予防看護学演習, 2024年, 修士課程, 保健科学院
• 予防看護学特論, 2024年, 修士課程, 保健科学院
• 実験研究方法特論, 2024年, 修士課程, 保健科学院
• 環境健康科学演習, 2024年, 修士課程, 保健科学院
• 環境健康科学特論, 2024年, 修士課程, 保健科学院
• 大学院共通授業科目（教育プログラム）：社会と健康, 2024年, 修士課程, 大学院共通科目
• 大学院共通授業科目（教育プログラム）：社会と健康, 2024年, 修士課程, 大学院共通科目
• 大学院共通授業科目（教育プログラム）：社会と健康, 2024年, 修士課程, 大学院共通科目
• 助産診断・技術学演習Ⅰ, 2024年, 修士課程, 保健科学院
• 応用疫学, 2024年, 修士課程, 医学院
• 食資源と健康, 2024年, 修士課程, 国際食資源学院
• 大学院共通授業科目（教育プログラム）：社会と健康, 2024年, 修士課程, 大学院共通科目
• 大学院共通授業科目（教育プログラム）：JICA開発大学院連携プログラム, 2024年, 修士課程, 大学院共通科目
• 大学院共通授業科目（教育プログラム）：社会と健康, 2024年, 修士課程, 大学院共通科目
• 健康科学特論, 2024年, 修士課程, 保健科学院
• 健康評価科学特講, 2024年, 博士後期課程, 保健科学院
• 健康評価科学特講演習, 2024年, 博士後期課程, 保健科学院
• 社会看護科学特講, 2024年, 博士後期課程, 保健科学院
• 社会看護科学特講演習, 2024年, 博士後期課程, 保健科学院
• 公衆衛生学Ⅰ, 2024年, 学士課程, 医学部
• 公衆衛生学Ⅱ, 2024年, 学士課程, 医学部
• 公衆衛生学概論, 2024年, 学士課程, 医学部
• 環境保健学, 2024年, 学士課程, 医学部
• 公衆衛生学実習, 2024年, 学士課程, 医学部
• 環境と人間（1単位）, 2024年, 学士課程, 全学教育
• アドバンスト演習, 2024年, 学士課程, 獣医学部
• 国際保健学, 2024年, 学士課程, 医学部

• International Society of Exposure Science
• International Society for Environmental Epidemiology
• 北海道公衆衛生学会
• SOCIETY OF INDOOR ENVIRONMENT, JAPAN
• JAPAN SOCIETY FOR OCCUPATIONAL HEALTH
• THE JAPANESE SOCIETY FOR HYGIENE
• The Pacific Basin Consortium for Environment and Health (PBC)
• The International Commission on Occupational Health (ICOH)

• 化学物質の次世代影響-出生から青年期の脂質代謝やエピゲノムの作用機序
  科学研究費助成事業
  01 Apr. 2023 - 31 Mar. 2026
  宮下 ちひろ; 池田 敦子; 田村 菜穂美; 山口 健史; 惠 淑萍
  日本学術振興会, 基盤研究(C), 北海道大学, 23K09641
• Effects of exposure to environmental chemicals on adolescent reproductive function, depression, and NCDs in the Hokkaido Study: Clarification of molecular mechanism
  Grants-in-Aid for Scientific Research
  01 Apr. 2022 - 31 Mar. 2026
  岸 玲子; 齊藤 卓弥; 池田 敦子; 山崎 圭子; 田村 菜穂美; 山口 健史; 宮下 ちひろ; 伊藤 佐智子; アイツバマイ ゆふ; 小林 澄貴
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (A), Hokkaido University, 22H00489
• 学童期の子どものピレスロイド系農薬への曝露と発達障がいとの関連
  科学研究費助成事業
  Apr. 2023 - Mar. 2026
  西原 進吉; 池田 敦子; 小林 澄貴
  日本学術振興会, 基盤研究(C), 北海道大学, Competitive research funding, 23K09642
• 有機フッ素化合物および新規類縁化合物の曝露実態と児の免疫系への健康影響の解明
  科学研究費助成事業
  01 Apr. 2022 - 31 Mar. 2025
  アイツバマイ ゆふ; 池田 敦子; 宮下 ちひろ; 岸 玲子; 山口 健史
  日本学術振興会, 基盤研究(B), 北海道大学, 22H03759
• Adverse health effects of environmental chemical exposure: elucidation of mechanisms via human and animal studies
  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)
  05 Apr. 2021 - 31 Mar. 2025
  荒木 敦子; 小島 弘幸; 増田 秀幸; 池中 良徳; Goudarzi Houman; POUDEL KRITIKA; 中村 明枝; アイツバマイ ゆふ
  疫学研究では、「北海道スタディ」に参加する9-11歳の前思春期児から収集した血漿を用いて、購入したBio-Plex200 multiplexアッセイシステムによりTh1/Th2関連サイトカイン17種類およびエオタキシン、糖尿病マーカー10種類およびアディポネクチンとアディプシンを約420検体測定した。同様に、9-11歳の学童339人の血漿を用いて、独自に開発した内標準物質による定量LC/MS分析法を利用し、血中各種コレステリルエステル（CE）11化合物の濃度測定を行った。なお、CE濃度が他のパラメーター、例えば性別や年齢、体格と関連性については現在解析中である。一般集団の子どもにおけるT2バイオマーカー（総IgE、好酸球、呼気中一酸化窒素（FeNO））の基準値を求めた。喘鳴、鼻結膜炎、湿疹といったアレルギー症状に加えて、性別（男児）と喫煙がT2バイオマーカー値を説明していた。
  リン酸トリエステル類曝露とT2バイオマーカーである血中総IgE、好酸球、FeNO、および表現型としての喘鳴、湿疹、鼻結膜炎の症状との関連を解析し、リン酸トリエステル類ΣTBOEPとΣTPHP濃度が高いと喘息、好酸球およびFeNOのリスクが高くなることが明らかになった。
  妊娠ICRマウスに、水（対照群）、PFOA 0.3 mg/kg（低用量群）及びPFOA 3 mg/kg（高用量群）を妊娠期間中経口曝露した。それぞれ出生後７日目の仔マウス肝臓からmRNAを採取した。GeneChip解析を用いた網羅的遺伝子発現解析を行い、PFOA投与量に応じて変動遺伝子数の上昇を認めた。また、高用量群マウスから生まれた仔マウスの肝臓は肥大しており、PFOAが胎盤や母乳を介して仔に影響したと考えられた。
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (A), Hokkaido University, 21H04843
• 学童期の有機リン・ネオニコチノイド系農薬曝露と子どもの注意および抑制機能との関連
  科学研究費助成事業 基盤研究(C)
  01 Apr. 2021 - 31 Mar. 2025
  山崎 圭子; 荒木 敦子; 須山 聡; 伊藤 佐智子
  本研究では、出生前向きコホート「北海道スタディ」の参加児を対象に、7歳時に採取・保存した尿中の有機リン・ネオニコチノイド系農薬曝露と、13歳時の認知機能およびADHD傾向との関連について解析する。有機リン・ネオニコチノイド系農薬への曝露評価は、既に採取済みの7歳時尿検体6000件のうち、ERPデータを得た参加者の検体を測定する。有機リン 6代謝物（DMP, DEP, DMTP, DMDTP, DETP, DEDTP）、ネオニコチノイド 7物質（ジノテフラン、ニテンピラム、チアメトキサム、クロチアニジン、イミダクロピリド、チアクリプリド、アセミタプリド）を、LC-MS/MSを用いて測定する。アウトカムとして事象関連脳電位（Event related brain potential: ERP）の測定およびADHD質問票を実施する。ERP測定時に用いるGo/No-go課題は注意および行動抑制機能の評価を行うための標準的な課題である。これにより記録されるERPとして、注意の容量を反映するP300、心的な反応抑制や反応の判断を反映するN2、運動反応の抑制を反映するNo-go P3が出現する。これらERPの振幅、潜時、頭皮上分布に調査票により評価するADHD傾向をアウトカムとする。本研究は、総体としてのADHD傾向よりも、それを構成する個々の認知機能に着目し、その測度として、生物学的な基盤を持つ脳波のERPを用いている。ADHD症状を個別の認知機能の面から解釈し、不全を起こしている機能を特定することにより、療育方法の改善にも寄与する可能性がある。当該年度にはこれらを踏まえ、アウトカムとなるERP測定およびADHD調査票の回収を中心に研究を進めた。
  日本学術振興会, 基盤研究(C), 北海道大学, 21K10435
• Potential role of club cell secretory protein (CC16) in development of obese asthma: findings from a birth cohort and animal studies
  科学研究費助成事業 基盤研究(C)
  01 Apr. 2020 - 31 Mar. 2023
  Goudarzi Houman; 荒木 敦子; 今野 哲
  1) Adult asthma cohort):BMI was significantly and monotonously associated with reduced circulating CC16 levels in adult asthmas patients. Also, CC16 was inversely associated with sputum eosinophils and blood periostin. Patients with the lowest tertile of serum CC16 levels at baseline had a -14.3 mL decline in FEV1 than those with the highest tertile over five years of follow-up (p for trend = 0.031).
  2) Population 2 (birth cohort): Ongoing.
  3) Animal study: The percentage of CC16-cells was reduced in the small airways of mice with obesity. In addition, serum CC16 levels were significantly lower in obese mice than in non-obese control mice. However, the serum levels of SP-A and SP-D, other products of club cells, did not vary between obese and non-obese control mice.
  日本学術振興会, 基盤研究(C), 北海道大学, 20K10425
• 胎児期環境の神経発達障害と脳の性分化および肥満への影響解明：出生コーホート研究
  科学研究費助成事業 基盤研究(A)
  01 Apr. 2019 - 31 Mar. 2023
  岸 玲子; 荒木 敦子; 小林 澄貴; 齊藤 卓弥; 湊屋 街子; 山崎 圭子; 中島 そのみ; 宮下 ちひろ; 白石 秀明; アイツバマイ ゆふ; 三浦 りゅう
  本研究は、出生コーホート研究で保存された母体血・臍帯血および学童期から思春期に採取した児の尿を用いて、胎児期および生後の環境化学物質曝露が児のアレルギー、神経行動発達、第二次性徴等のアウトカムへ及ぼす影響についてリスク評価を行うことを目的とした。
  令和3年度は、出生コーホートの参加者について11歳で第二次性徴に関する調査票1182件、12歳で小学校の学校健診記録から転記する身長体重調査票1236件、15歳で中学校の身長体重調査票1440件、17歳調査1787件を発送した。回収数は11歳812件（回収率68.7.％）、12歳771件（回収率62.4％）、15歳815件（回収率56.5％）、17歳855件（47.8％）であった。生後のアウトカム評価として、これまでの質問票調査によるアレルギー、神経行動発達、第二次性徴の評価を行った。脳波調査では、有機フッ素化合物（PFAS）の胎児期曝露が児の認知機能に関連する可能性を検討した。妊娠初期母体血清中のフタル酸7代謝物と第二次性徴発来のタイミングおよび、成長や肥満などの体格との解析を実施した。
  日本学術振興会, 基盤研究(A), 北海道大学, 19H01071
• Investigation of neurodevelopmental risks in children associated with pesticide exposure: Using genetic polymorphisms (SNPs) analysis.
  Grants-in-Aid for Scientific Research
  01 Apr. 2019 - 31 Mar. 2022
  Nishihara Shinkichi
  Measuring metabolites of neonicotinoid and organophosphorus pesticides in urine samples from school-age children, this study examined the association between exposure to these pesticides and children's ADHD scores. As a result, no significant associations were observed for neonicotinoid pesticides or for organophosphorus pesticides.This suggests that exposure to these pesticides is not associated with an increase in ADHD tendency in children if the concentrations are at levels that children in the general urban population can be exposed to in their normal daily lives. However, interpretation may need to be done with caution for imidacloprid, one of the neonicotinoid pesticides, because the odds ratio tends to increase, although the difference has not reached significance.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 19K10576
• Perfluorinated alkyl substances exposure and onset of puberty - birth cohort and in vitro studies
  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
  01 Apr. 2018 - 31 Mar. 2022
  Ikeda Atsuko
  Per and polyfluorinated substances (PFAS) is a class of chemicals known for "endocrine disrupting” effects. A birth cohort study examined the effects of prenatal PFAS exposure on gonadal function and onset of puberty. Prenatal PFAS exposure lowered testosterone levels and increased progesterone and INSL3 levels at birth. PFTrDA delayed the age of menarche in girls. ESR1 polymorphisms may modulate the effects of PFAS on sexual differentiation. In vitro study, PFOA and PFNA showed agonist activity of ERalpha and PPARalpha. PFOA and PFNA were agonists of ERalpha and PPARalpha, whereas no agonist of antagonist activation of ERbeta, AR, GR, TR. Up or down regulation of about 800-intracellular gene expression were observed upon PFOA exposure, including PPARalpha receptors signaling genes and cytokines and IgE related genes.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hokkaido University, 18H03035
• Gene-epigenome-environment interactions in cohort longitudinal study: early prevention of school aged obesity
  Grants-in-Aid for Scientific Research
  28 Jun. 2019 - 31 Mar. 2021
  Kishi Reiko
  The aim of this study was to identify epigenomic changes involved in fetal environment and postnatal disease and health status. In a case-sub-cohort study including 218 obesity and 282 non-obesity children, we analyzed epigenome wide association study analysis (EPIC) in cord blood DNA. In robust linear regression, methylation rate of only 1 CpG site was significantly differenced with/without maternal pre-pregnancy obesity (FDR q < 0.05). Among only mothers having male offspring, methylation rate of 2 CpG sites were differenced with/without maternal pre-pregnancy obesity (FDR q < 0.1). In KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway analysis, functional pathways of nutrient metabolism, inflammation and immune system were detected as linking to maternal pre-pregnancy's obesity.
  Japan Society for the Promotion of Science, Grant-in-Aid for Challenging Research (Exploratory), Hokkaido University, 19K22730
• Thyroid function disrupting effects of fetal exposure to POPs on ADHD symptoms in children
  Grants-in-Aid for Scientific Research
  01 Apr. 2018 - 31 Mar. 2021
  Itoh Sachiko
  We investigated the associations between prenatal exposure to perfluoroalkyl substances(PFASs) and the thyroid hormones(THs) and thyroid antibodies(TAs) in maternal and cord blood while considering maternal TAs status. Maternal PFASs were differently associated with THs and TAs of children between in maternal TA-negative group and TAs-positive group, and between boys and girls. Additionally, we investigated the impact of maternal PFAS exposure on children’s attention deficit hyperactive disorder(ADHD) symptoms at 8 years with the mediating effect of TH and TA. Significant inverse associations were found between some PFASs in maternal serum and ADHD symptoms among firstborn children. Assuming causality, we found only one significance: the maternal FT4 mediated 16.3% of the estimated effect of PFUnDA exposure on hyperactivity-impulsivity among firstborn children.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 18K10042
• Effects of exposure to environmental chemicals on child's neurodevelopment, puberty onset, and allergies in the Hokkaido Study:Clarification of molecular mechanism
  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)
  01 Apr. 2016 - 31 Mar. 2019
  Kishi Reiko; Kajiwara Junboku; Sata Fumihiro; Saijo Yasuaki; Yoshioka Eiji
  To investigate the effects of pre-and postnatal exposure to environmental chemicals on child’s neurodevelopment, puberty onset, and allergies, we evaluated these adverse health impacts in terms of single and multiple exposures, as well as gene-environment interaction.
  A significant decreasing secular trend of urinary MEHP concentration of 7 years old children was found in the sample collected between 2012 and 2017. Prenatal exposures to MECPP was associated with increase a risk of behavioral problems among 5 years old children and MnBP, MiBP, MEHP were associated with early puberty onset among girls. Prenatal exposure to BPA did not have any associations with neurodevelopment or puberty onset. Prenatal exposure to multiple chemicals disrupted sex hormone levels in cord blood, especially MEHP and PFOS were highly contributions to hormone levels. A significant decreasing 2D:4D ratio was found in cord blood XbaI polymorphism of estrogen receptor 1 gene.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (A), Hokkaido University, 16H02645
• Research on the status and its related factors of Mother-Child interaction frequency in Japanese women, an adjunct study of the Japan Environment and Children's Study.
  Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
  01 Apr. 2015 - 31 Mar. 2019
  Kawanishi Yasuyuki; SAIJO Yasuaki; YOSHIOKA Eiji; KISHI Reiko; ARAKI Atsuko; ITO Yoshiya
  This study aimed to develop a mother-infant interaction frequency scale and to clarify its related factors. As an adjunct study of the Japan Environment and Children's Study, a self-administered questionnaire was conducted on the Hokkaido unit center participants whose children were 3.5 to 4 years old, and factor analysis was performed. As a result of the analysis, four factors were extracted: "affective physical contact, cultural interaction, active physical contact, staring". We performed multiple regression analyses using this mother-infant interaction scale (16-80 points) as the objective variable, and data up to one month after delivery as an explanatory variable. As a result, parity, BMI before pregnancy, frequency of contact with close people, and the number of friends/neighbors to whom she can talk freely were significantly associated with this scale.
  Japan Society for the Promotion of Science, Grant-in-Aid for Young Scientists (B), Asahikawa Medical College, 15K20844
• Elucidation of molecular mechanism of ADHD based on a prospective birth cohort study
  Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research
  01 Apr. 2016 - 31 Mar. 2018
  Reiko kishi; AIT BAMAI Yu; KOBAYASHI Sumitaka
  We targeted DNA methylation as a mediator between prenatal exposure to environmental chemicals and attention-deficit/hyperactivity disorder (ADHD). We assessed methylation levels at 450K cytosine-guanine dinucleotide sites (CpGs) in cord blood DNA using an Illumina HumanMethylation 450 BeadChip, and examined association between methylation and prenatal exposure to perfluoroalkyl substances, phthalates, and bisphenol A. The epigenome-wide analyses (EWAS) showed significant differences in methylation associated with prenatal exposure.
  To investigate prospective association between DNA methylation at birth and ADHD-related behavior at 6 years, we extracted DNA from cord blood of ADHD groups (n=245) identified with ADHD rating scale (ADHD-RS) and control groups （n=317）. Using a next-generation sequencer, we have quantified methylation levels at CpGs that showed significant association with prenatal exposure in the EWAS.
  Japan Society for the Promotion of Science, Grant-in-Aid for Challenging Exploratory Research, Hokkaido University, 16K15352
• Association between maternal dioxin levels during pregnancy and genetic polymorphisms on infant epigenetic effects
  Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
  01 Apr. 2016 - 31 Mar. 2018
  KOBAYASHI Sumitaka; MIYASHITA Chihiro; ARAKI Atsuko
  Using prospective birth cohort, I examined an association between maternal dioxin levels in blood during pregnancy and genetic polymorphisms of genes encoded dioxin-metabolizing receptor and enzymes (aromatic hydrocarbon receptor [AHR], cytochrome P450 [CYP] 1A1, CYP1A2, CYP1B1, and glutathione S-transferase mu1 [GSTM1]) on levels of infant DNA methylation (insulin-like growth factor-2 [IGF-2], H19, and long interspersed nuclear element-1 [LINE-1]). None of maternal genotypes showed the effects of infant IGF-2, H19, and LINE-1 methylation levels for maternal dioxin levels during pregnancy. In conclusion, maternal genetic polymorphisms of genes encoded dioxin-metabolizing receptor and enzymes did not modify the association between maternal dioxin levels in blood during pregnancy and levels of infant IGF-2, H19, and LINE-1 methylation.
  Japan Society for the Promotion of Science, Grant-in-Aid for Young Scientists (B), Hokkaido University, 16K19243
• FLG variance and environmnetal chemical exposure to atopic dermatitis among school children
  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
  01 Apr. 2015 - 31 Mar. 2018
  Atsuko Araki; SHIMIZU Hiroshi; KOBAYASHI Sumitaka; MINATOYA Machiko; AIT BAMAI Yu; ITO Sachiko; TAKEUCHI Shinji; URAMARU Naoto; OKUDA Katsuhiro; TAKEDA Mai; KAWAI Toshio
  Association between environmental chemicals exposure on asthma and allergies and oxidative stress marker, 8-OHdG, and existence of FLG mutation were examined among 7 years old children. There was no difference on proportion of with or without FLG mutation between allergic cases and controls. When DINP levels in dust was higher, the risk of eczema increased, only those without FLG mutation. There was no significant association between FLG mutation, environmental chemicals and asthma and allergies, and 8-OHdG did not show any modifier effect on exposure and allergies. Studies of in vitro and in silico of DEHP and its 6 metabolites activation on PPARα/γ and PXR showed that DEHP and its metabolites have activities that differ from those of the parent compound. The results obtained from the microarray analysis suggest that DEHP and MEHP might affect the gene expression of THP-1 cells via PPARα and PXR.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hokkaido University, 15H04780
• Evaluation of fetal environmental risk by Mendel randomization analysis and gene-environment interactions
  Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research
  01 Apr. 2015 - 31 Mar. 2018
  Sata Fumihiro; NONOMURA Katsuya; MITSUI Takahiko; KOBAYASHI Sumitaka
  I have published original articles in academic journals and presented at academic meetings on the topic of effects of gene-environment interactions on birth weight, head circumference, and Kaup indices with respect to maternal active and passive smoking, caffeine intake, exposure to polychlorinated biphenyls and dioxins during pregnancy, and genetic polymorphisms of genes encoding metabolic and DNA repair enzymes and receptors.
  I have also reviewed a series of epidemiological studies related to the concept of the developmental origins of health and disease (DOHaD), especially recent large-scale genome-based birth cohort studies such as genome-wide association studies and epigenome-wide association studies, including Mendelian randomization studies.
  In addition, I have started a research group called DOHaD Seminar of Epidemiology to emphasize on educational activities based on the DOHaD concept.
  Japan Society for the Promotion of Science, Grant-in-Aid for Challenging Exploratory Research, 15K15220
• Phthalate exposure and its effects on onset of puberty
  Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research
  01 Apr. 2014 - 31 Mar. 2017
  Araki Atsuko; KISHI Reiko; AITBAMAI Yu
  Phthalates are ubiquitous environmental chemicals, which are widely used as plasticizes. Humans are exposed to phthalates since fetal life, and their endocrine disrupting properties has been concerned. However, prenatal exposure to phahalates and their effects on fetus onset of puberty in human are not well known. In this study, onset of puberty were examined among children registered to Sapporo cohort, the Hokkaido Study. Among those approached, 150 (45.6%) responded. Total effects of MEHP (primary metabolite of the most widely used phthalate, DEHP) levels in maternal blood was significantly positively associated with onset of puberty; natural log increase of MEHP (app. 2.67), onset of puberty delayed 7.17（95%CI：2.89-11.5）months among boys. Although progesterone and inhibin B were inversely associated with MEHP, none of hormones showed indirect effect of MEHP to onset of puberty. Girls did not show any association between MEHP, hormones, or onset of puberty.
  Japan Society for the Promotion of Science, Grant-in-Aid for Challenging Exploratory Research, Hokkaido University, 26670321
• Investigation of adverse health effects of environmental chemicals by a birth cohort study:focused on gene environment interactions
  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)
  01 Apr. 2013 - 31 Mar. 2016
  Kishi Reiko; IKENO Tamiko; ARAKI Atsuko; MIYASHITA Chihiro; NAKAJIMA Sonomi; SASAKI Seiko; HANAOKA Tomoyuki; KAJIWARA Junboku; MATSUURA Hideyuki; MUROHASHI Harumitsu; SIRAISHI Hideaki; SATA Fumihiro; SAIJO Yasuaki; YOSHIOKA Eiji; AZUMI Kaoru
  20,000 mother-infant pairs were recruited in 40 obstetric hospitals in Hokkaido, Japan. We investigated the association between prenatal exposure to tobacco smoke, dioxins and perfluorinated compounds and several developmental outcomes such as e infant growth, neurodevelopment, and allergy after birth until 8 year-old.
  We observed that prenatal chemical exposures were associated with (1) peroxisomal proliferator-activated receptor beta (PPARβ) genetic polymorphism on serum lipid in maternal blood, (2) DNA repairing (X-ray cross-complementing gene 1; XRCC1) genetic polymorphisms on infant birth weight, (3) insulin growth factor 2 (IGF2) methylation in cord blood, and (4) infant neurodevelopment at 1.5-year-old. In addition, we attempted to identify the risk factor of the attention deficit/hyperactivity disorder (AD/HD), the result showed that alcohol drinking and smoking increased the odds ratio.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (A), Hokkaido University, 25253050
• Environmental and Genetic risk factors of Atopic dermatitis among 7-year old children in birth cohort
  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
  01 Apr. 2012 - 31 Mar. 2015
  ARAKI Atsuko; NOMURA Toshifumi; KISHI Reiko; SHIMIZU Hiroshi; SASAKI Seiko; AIT BAMAI Yu; TAJIMA Shuji; UKAWA Shigekazu; CONG Shi
  The present study examined the risk of environmental factors such as mite allergens, phthalates, and organophosphate in house dust and filaggrin (FLG) gene variants on atopic dermatitis (AD) among 7 years old children who are participating in the Hokkaido study on Environment and Children's Health. About 10% of the participants in this study had FLG gene variants, which was consistent with other previous studies. The children with FLG gene variants significantly increased the risk of AD at 2 and 4 years of age, but were not at 7 years of age. Among 7 years old children with high levels of DiNP and without FLG gene variants significantly increased the risk of AD.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hokkaido University, 24390152
• To detect the environmental risk factors relating to developmental disorder in school-children and prevention used nested case-control study.
  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
  01 Apr. 2012 - 31 Mar. 2015
  IKENO Tamkio; MUROHASHI Harumitsu; SHIRAISHI Hideaki; SASAKI Seiko; KISHI Reiko; ARAKI Atsuko; AZUMI Kaoru
  In this study, we examined the effects of environmental factors on risk of attention hyperactivity diorder (ADHD) in a prospective birth cohort with more than 20,000 participants. 1)We assessed the effects of smoking exposure during pregnancy and at age 7 years old, using ADHD rating scale (ADHD-RS). We found that home environment and maternal depression have more effects on ADHD-RD than smoking exposure. 2)We determined IQ of 179 children using WISC-IV test in a nested case -control study. 3) We investigated single nucleotide polymorphisms(SNPs) of neurotransmitter related gene （DRD4,DAT1,HTR1B,COMT,SNAP25）and brain-derived neurotrophic factor （BDNF）by EP1 system (Fludigm)in ADHD-suspected and control groups. We have finished SNPs determination in 200 subjects of 390 statistical power.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 24590777
• The effects of prenatal exposures to environmental chemicals and genetic susceptibility on growth, neurodevelopment and allergy of next generation
  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)
  01 Apr. 2010 - 31 Mar. 2014
  KISHI REIKO; YOSHIOKA Eiji; SASAKI Seiko; MUROHASHI Harumitsu; NAKAJIMA Sonomi; SHIRAISHI Hideaki; AZUMI Kaoru; IKENO Tamiko; ARAKI Atsuko; HANAOKA Tomoyuki; KAJIWARA Junboku; SAITO Kouichi; SATA Fumihiro; SAIJO Yasuaki; ITOH Sachiko; MIYASHITA Chihiro
  514 pregnant women were recruited in one obstetric hospital in Sapporo. We investigated the correlation of prenatal exposures to PCBs/PCDDs/PCDFs, PFOS and PFOA with child growth, neurodevelopment, and allergy in next generation until school age. A follow-up questionnaire was used at 18, 42, and 84 months of age to obtain relevant information including infant symptoms and lifestyle factors. The Bayley Scale of Infant Development second edition at age of 6 and 18 months, and the Kaufman Assessment Battery for Children and the Child Behavior Checklist at age 42 to 43, 84 months were employed to collect information on child behavior. At age of 84 months the Wechsler Intelligence Scale for Children was used to assess the effects of environmental chemicals on cognitive ability. The levels of PCBs/PCDDs/PCDFs and PFOS/PFOA in maternal blood were analyzed by a high-resolution gas chromatography/high-resolution mass spectrometer and liquid chromatography-tandem mass spectrometry respectively.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (A), Hokkaido University, 22249021