Researcher basic information

• 博士(獣医学), 北海道大学, Sep. 2014

• https://researchmap.jp/teppeinakamura?lang=en

• https://orcid.org/0000-0003-3204-0245
• https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201801004552017181

• https://orcid.org/0000-0003-3204-0245

• 201801004552017181

• Life Science, Laboratory animal science
• Life Science, Anatomy
• Life Science, Veterinary medical science

• Bachelor's degree program, School of Veterinary Medicine
• Doctoral (PhD) degree program, Graduate School of Veterinary Medicine

Research activity information

• Mar. 2012, 日本獣医解剖学会, 日本獣医解剖学会奨励賞
  中村 鉄平

• Three-dimensional structure and epithelial changes of the piriform sinus fistula in cotton rats
  Teppei Nakamura; Marina Hosotani; Osamu Ichii; Takao Irie; Akio Shinohara; Hirokazu Kouguchi; Yasuhiro Kon
  Cell and Tissue Research, 403, 3, Springer Science and Business Media LLC, 26 Feb. 2026, [Peer-reviewed], [Lead author, Corresponding author]
  Scientific journal
• Protoscolex Maturation in Echinococcus multilocularis Is Controlled by Host Genetic Factors Independent of Initial Development
  Moe Kogawa; Keisuke Sato; Teppei Nakamura; Naoki Hayashi; Hirokazu Kouguchi; Ryo Nakao; Masahito Hidaka; Hiroyuki Matsuyama; Nariaki Nonaka; Osamu Ichii; Takashi Agui; Masami Morimatsu
  Parasite Immunology, 48, 2, Wiley, Feb. 2026, [Peer-reviewed], [Lead author]
  Scientific journal
• Dual-route medetomidine-alfaxalone-butorphanol anesthesia: a refined protocol for balanced anesthesia in male rabbits.
  Risa Iwanaga; Munekatsu Ita; Kanako Sumi; Chizuko Kodama; Mohammad Ibrahim Qasimi; Jun Tamura; Ko Nakanishi; Kayoko Matsumura; Masami Morimatsu; Yasuhiro Yoshida; Teppei Nakamura
  Experimental animals, 74, 4, 399, 406, Japanese Association for Laboratory Animal Science, 08 Oct. 2025, [Peer-reviewed], [Corresponding author], [Domestic magazines]
  English, Scientific journal, Injectable anesthesia is widely used in laboratory animals because of its ease of administration and minimal equipment requirements. However, it necessitates careful monitoring as well as thermal and oxygen support. This study evaluated the efficacy of medetomidine-alfaxalone-butorphanol (MAB) anesthesia in male rabbits using a dual-route administration protocol. The anesthetic doses were as follows: medetomidine, 0.2 mg/kg; alfaxalone, 2.0 mg/kg; and butorphanol, 2.0 mg/kg. MAB anesthesia, administered via intravenous and subcutaneous routes, induced rapid and smooth induction, achieving anesthetic scores comparable to those of medetomidine-midazolam-butorphanol (MMB) anesthesia. MAB anesthesia resulted in mild hypothermia during the procedure. Upon atipamezole administration, rabbits under MAB anesthesia exhibited faster recovery of the righting reflex and respiration rate than those under MMB. Importantly, no abnormal behaviors, such as jumping or agitation, were observed during induction or recovery, as reported with alfaxalone use in other species. Both protocols maintained spontaneous breathing, although transient hypoxemia was observed in all rabbits. The dual-route MAB protocol provided effective anesthesia while addressing the limitations of conventional MMB anesthesia in rabbits, suggesting its potential as a refined anesthetic method for this species. Unlike mice, which showed weaker anesthetic effects with MAB compared to MMB, MAB demonstrated superior anesthetic properties in rabbits. This study highlights the importance of species-specific anesthetic protocols and the potential benefits of MAB anesthesia in rabbits, particularly its smooth induction and recovery profile, without adverse behaviors often associated with alfaxalone in other species.
• Efferocytosis-Driven M2 Macrophage Impairs Fibrotic Encapsulation and Promotes Echinococcus multilocularis Growth in Cotton Rats (Sigmodon hispidus)
  Maru Manabe; Teppei Nakamura; Keisuke Sato; Naoki Hayashi; Hirokazu Kouguchi; Ryo Nakao; Masahito Hidaka; Hiroyuki Matsuyama; Nariaki Nonaka; Masami Morimatsu
  Microscopy and Microanalysis, 03 Sep. 2025, [Peer-reviewed], [Lead author, Corresponding author]
  Scientific journal
• Multi-laboratory Validation of Join of the Five Dyes Revealing Collagenous Tissue (JFRL) Staining for Bone Histology Across Animal Species and Bone Implant Materials
  Erika Tsuji; Kanako Sumi; Natsuko Tsuzuki; Daisuke Kondoh; Masashi Tsujio; Marina Hosotani Saito; Takashi Namba; Shoichi Wakitani; Osamu Ichii; Ko Nakanishi; Teppei NAKAMURA
  Microscopy and Microanalysis, 31, 4, Oxford University Press (OUP), 15 Jul. 2025, [Peer-reviewed], [Corresponding author]
  Scientific journal
• Pharmacokinetics and the effectiveness of pyrogen-free bioabsorbable wet adhesives
  Risa Oshima; Kumiko Yoshihara; Ko Nakanishi; Tsukasa Akasaka; Shinji Shimoji; Teppei Nakamura; Takumi Okihara; Mariko Nakamura; Akihiro Matsukawa; Ikkei Tamada; Bart Van Meerbeek; Tsutomu Sugaya; Yasuhiro Yoshida
  Scientific Reports, 15, 1, Springer Science and Business Media LLC, 12 Jun. 2025, [Peer-reviewed]
  Scientific journal
• Altered morphology of mucosa-associated lymphoid tissues and epithelium in the nasal cavity and lacrimal apparatus in autoimmune disease-prone MRL/MpJ-Faslpr/lpr mice
  Masaya Hiraishi; Takashi Namba; Teppei Nakamura; Md. Zahir Uddin Rubel; Yasuhiro Kon; Osamu Ichii
  Cell and Tissue Research, Springer Science and Business Media LLC, 25 Mar. 2025, [Peer-reviewed]
  Scientific journal
• Application of chlorous acid water for disinfection of surgical site in dairy cows
  Osamu Ichii; Teppei Nakamura; Masaya Hiraishi; Takashi Namba; Md. Zahir Uddin Rubel; Takuya Umeyama; Megumi Asai
  Frontiers in Veterinary Science, 26 Feb. 2025, [Peer-reviewed], [Lead author]
  Scientific journal, Disinfection is crucial for preventing surgical site infections. Recently, the effectiveness of sanitizers using chlorous acid (HClO2) under conditions rich in organic matter has been reported, and chlorous acid water (CAW) has been approved as a food additive. This study evaluated the potential of CAW as a new presurgical disinfectant for cattle. The experiments were performed on the paralumbar fossa of cattle in Sapporo during March (winter to spring) and August (summer). Colony-forming units (CFUs) of standard plate count bacteria (SPCB), Enterococcus faecalis (EF), Pseudomonas aeruginosa, Escherichia coli, and Staphylococcus spp. (SP) were analyzed as indicators of bacterial load. SPCB and SP were abundantly detected, exceeding 6 log10 CFU/100 g on clipped hair and 6 log10 CFU/100 cm2 on the skin immediately after clipping, with no significant seasonal differences. The bacterial load on the skin was evaluated at three time points: after clipping, cleansing, and disinfection. Clipping and cleansing with liquid soap were common procedures, following this, either the standard disinfection protocol using 7.5% iodine scrub for 1 min, 10% povidone-iodine for 5 min, and 70% alcohol for 5 min (SPA), or a modified protocol using CAW with contact times of 15, 10, or 5 min (CAW15, CAW10, CAW5) were performed separately. The cleansing procedure significantly reduced the SPCB, EF, and SP on the skin after clipping, and all disinfection methods significantly decreased the SP after cleansing. Draping significantly enhanced the disinfection efficiency of the SPA, CAW10, and CAW5 protocols. The CAW procedure did not alter skin histology in the paralumbar fossa or udder compared to 10% povidone-iodine or 70% alcohol. Our data suggest that the disinfection method using CAW is useful and comparable to routine disinfection methods and might reduce the time required for presurgical disinfection in farm fields.
• New future dental material: Antimicrobial material "cetylpyridinium chloride-montmorillonite" and implantable material "phosphorylated pullulan".
  Ko Nakanishi; Tsukasa Akasaka; Yasuhiko Abe; Hiroshi Hayashi; Kumiko Yoshihara; Teppei Nakamura; Mariko Nakamura; Bart VAN Meerbeek; Yasuhiro Yoshida
  Dental materials journal, 11 Jan. 2025, [Peer-reviewed], [Domestic magazines]
  English, Scientific journal, In dental practice, there are two major diseases: dental caries and periodontal disease. Although dental treatment techniques have advanced along with advances in dental materials, some diseases such as root surface caries and horizontal bone resorption have not yet achieved satisfactory treatment results. Since these diseases are infections caused by oral bacteria, we believe that materials with long-lasting antimicrobial properties would help control these diseases. In addition, materials that can adhere to wet hard tissues would contribute to treatment. In this review, new materials developed based on this idea, the antimicrobial material "cetylpyridinium chloride-montmorillonite" and the hard tissue adhesive implantable material "phosphorylated pullulan" was introduced.
• Effects of autoimmune abnormalities on fertility and placental morphology in mice
  Risa Yamanaka; Osamu Ichii; Teppei Nakamura; Yuki Otani; Takashi Namaba; Yasuhiro Kon
  Autoimmunity, 31 Dec. 2024, [Peer-reviewed]
  Scientific journal
• Dual-route administration of balanced anesthesia using medetomidine, midazolam, and butorphanol provides both suitable anesthetic depth and reduced tissue injury in rabbits
  Risa IWANAGA; Kanako SUMI; Chizuko KODAMA; Munekatsu ITA; Mohammad Ibrahim QASIMI; Jun TAMURA; Ko NAKANISHI; Yasuhiro YOSHIDA; Masami MORIMATSU; Kayoko MATSUMURA; Teppei NAKAMURA
  Experimental Animals, 23 Nov. 2024, [Peer-reviewed], [Corresponding author], [Domestic magazines]
  English, Scientific journal
• Mouse oligoadenylate synthetase 1b inhibits West Nile virus replication by acting through the stem-loop 2 in the 3′-untranslated region
  Keisuke Sato; Teppei Nakamura; Masami Morimatsu; Takashi Agui
  Japanese Journal of Veterinary Research, 30 Oct. 2024, [Peer-reviewed]
  English, Scientific journal
• Collagen 17A1 in the Urothelium Regulates Epithelial Cell Integrity and Local Immunologic Responses in Obstructive Uropathy
  Takashi Namba; Osamu Ichii; Ken Natsuga; Teppei Nakamura; Yuki Otani; Yasuhiro Kon
  The American Journal of Pathology, Aug. 2024, [Peer-reviewed]
  Scientific journal
• From Tooth Adhesion to Bioadhesion: Development of Bioabsorbable Putty-like Artificial Bone with Adhesive to Bone Based on the New Material “Phosphorylated Pullulan”
  Ko Nakanishi; Tsukasa Akasaka; Hiroshi Hayashi; Kumiko Yoshihara; Teppei Nakamura; Mariko Nakamura; Bart Van Meerbeek; Yasuhiro Yoshida
  Materials, 25 Jul. 2024, [Peer-reviewed]
  Scientific journal
• Species-specific histological characterizations of renal tubules and collecting ducts in the kidneys of cats and dogs
  Shunnosuke Kira; Takashi Namba; Masaya Hiraishi; Teppei Nakamura; Yuki Otani; Yasuhiro Kon; Osamu Ichii
  PLOS ONE, 19, 7, e0306479, e0306479, Public Library of Science (PLoS), 03 Jul. 2024, [Peer-reviewed]
  Scientific journal, The histomorphological features of normal kidneys in cats and dogs have been revealed despite the high susceptibility of cats to tubulointerstitial damage. Herein, the histological characteristics of the two species were compared. Cytoplasmic lipid droplets (LDs) were abundant in the proximal convoluted tubules (PCTs) of cats aged 23–27 months but scarce in dogs aged 24–27 months. LDs were rarely observed in the distal tubules (DTs) and collecting ducts (CDs) of either species, as visualized by the expression of Tamm–Horsfall protein 1, calbindin-D28K, and aquaporin 2. The occupational area ratio of proximal tubules (PTs) in the renal cortex was higher, but that of DTs or CDs was significantly lower in adult cats than in dogs. Single PT epithelial cells were larger, but PCT, DT, and CD lumens were significantly narrower in adult cats than in dogs. Unlike adults, young cats at 6 months exhibited significantly abundant cytoplasmic LDs in proximal straight tubules, indicating lipid metabolism-related development. Histochemistry of the 21 lectins also revealed variations in glycosylation across different renal tubules and CDs in both species. Sodium-glucose cotransporter 2 was expressed only in PTs, excluding the proximal straight tubules with few LDs in adult cats or the PCTs of young cats and adult dogs. These findings are crucial for understanding species-specific characteristics of renal histomorphology and pathogenesis.
• Functional Analysis of Oligoadenylate Synthetase in the Emu (Dromaius novaehollandiae)
  Keisuke Sato; Teppei Nakamura; Masami Morimatsu; Takashi Agui
  Animals, 27 May 2024, [Peer-reviewed]
  Scientific journal
• Phenotypes of streptozotocin-induced gestational diabetes mellitus in mice
  Narumi Takahashi; Osamu Ichii; Masaya Hiraishi; Takashi Namba; Yuki Otani; Teppei Nakamura; Yasuhiro Kon
  PLOS ONE, 19, 4, Public Library of Science (PLoS), 16 Apr. 2024, [Peer-reviewed]
  Scientific journal
• Systemic autoimmune abnormalities alter the morphology of mucosa-associated lymphoid tissues in the rectum of MRL/MpJ-Faslpr/lpr mice.
  Md Zahir Uddin Rubel; Osamu Ichii; Takashi Namba; Md Abdul Masum; Tsolmon Chuluunbaatar; Masaya Hiraishi; Teppei Nakamura; Yasuhiro Kon
  Experimental animals, 02 Feb. 2024, [Peer-reviewed], [Domestic magazines]
  English, Scientific journal, Systemic autoimmune diseases (ADs) might affect the morphology and function of gut-associated lymphoid tissue (LTs) indirectly; however, their exact relationship remains unclear. Therefore, we investigated mouse LTs in the anorectal canal and morphologically compared them between MRL/MpJ-Fas+/+ and MRL/MpJ-Faslpr/lpr mice. LT aggregations, also known as rectal mucosa-associated lymphoid tissues (RMALTs), were exclusively seen in the lamina propria and submucosa of the rectum. The mean size and number of the LT aggregations both significantly increased in MRL/MpJ-Faslpr/lpr mice compared to those in MRL/MpJ-Fas+/+ mice. The distance from the anorectal junction to the first LT aggregate was significantly shorter in MRL/MpJ-Faslpr/lpr mice than that in MRL/MpJ-Fas+/+ mice. Immunostaining revealed that the RMALTs included CD3+,CD4+, and CD8+ T cells; B220+ B cells; IBA1+ macrophages; Ki67+ proliferative cells; and PNAd+ high-endothelial venules (HEVs). The numbers of macrophages, proliferative cells, CD4+ T cells, CD8+ T cells, and HEVs were significantly increased in MRL/MpJ-Faslpr/lpr mice compared to those in MRL/MpJ mice. Furthermore, the gene expression levels of chemokines (Cxcl9 and Cxcl13) and their corresponding receptors (Cxcr3 and Cxcr5) were significantly higher in MRL/MpJ-Faslpr/lpr mice than those in MRL/MpJ-Fas+/+ mice. Although the morphology of rectal epithelium was comparable between the strains, M cell number was significantly higher in MRL/MpJ-Faslpr/lpr mice than in MRL/MpJ-Fas+/+ mice. Thus, ADs could alter RMALT morphology, and quantitative changes in T-cell subsets, proliferative cells, macrophages, HEVs, chemokine expression, and M cells could affect their cell composition and development.
• Structural Features of Connective Tissue Formed around Resin Implants Subcutaneously Embedded in Dairy Cows
  Yuka Katayama; Osamu Ichii; Teppei NAKAMURA; Keita Yanase; Masaya Hiraishi; Takashi Namba; Yuki Otani; Teppei Ikeda; Erika Tsuji; Natsuko Tsuzuki; Ken Kobayashi; Yasuhiro Kon; Takanori Nsihimura
  Animals, 29 Nov. 2023, [Peer-reviewed]
  Scientific journal
• Ameliorated Renal Pathological Feature in MRL/MpJ-Faslpr/lpr Background Interleukin-36 Receptor-Deficient Mice.
  Takashi Namba; Osamu Ichii; Tadashi Okamura; Kenta Nakano; Teppei Nakamura; Yuki Otani; Yasuhiro Kon
  Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada, 29, 2, 675, 685, 05 Apr. 2023, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Systemic autoimmune diseases frequently induce lupus nephritis, causing altered balance and expression of interleukin 36 receptor (IL-36R) ligands, including agonists (IL-36α, β, γ) and antagonists (IL-36Ra, IL-38), in kidneys. Here, we established and analyzed a mouse model of lupus nephritis, MRL/MpJ-Faslpr/lpr with IL-36R-knockout (KO), compared to wild-type (WT) mice. In both genotypes, indices for immune abnormalities and renal functions were comparable, although female WT mice showed higher serum autoantibody levels than males. IL-36R ligand expression did not differ significantly between genotypes at the mRNA level or in IL-36α and IL-38 scores. However, glomerular lesions, especially mesangial matrix expansion, were significantly ameliorated in both sexes of IL-36R-KO mice compared to WT mice. Cell infiltration into the tubulointerstitium with the development of tertiary lymphoid structures was comparable between genotypes. However, the positive correlation with the IL-36α score in WT mice was not evident in IL-36R-KO mice. Fibrosis was less in female IL-36R-KO mice than in WT mice. Importantly, some IL-36α+ nuclei co-localized with acetylated lysine and GCN5 histone acetyltransferase, in both genotypes. Therefore, IL-36R ligands, especially IL-36α, contribute to the progression of renal pathology in lupus nephritis via IL-36R-dependent and IL-36R-independent pathways.
• Expression of Indian hedgehog signaling in murine oviductal infundibulum and its relationship with epithelial homeostasis
  Marina Hosotani; Osamu Ichii; Takashi Namba; Md. Abdul Masum; Teppei Nakamura; Yasuhiro Hasegawa; Takafumi Watanabe; Yasuhiro Kon
  Cell and Tissue Research, Springer Science and Business Media LLC, 29 Dec. 2022, [Peer-reviewed]
  Scientific journal
• Ureteral morphology and pathology during urolithiasis in cats.
  Osamu Ichii; Kazuhisa Oyamada; Hazuki Mizukawa; Nozomu Yokoyama; Takashi Namba; Yuki Otani; Yaser Hosny Ali Elewa; Noboru Sasaki; Teppei Nakamura; Yasuhiro Kon
  Research in veterinary science, 151, 10, 20, 11 Jul. 2022, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Cats exhibit high susceptibility to urinary organ-related diseases. We investigated the healthy ureter morphologies and compared these with ureters that were surgically resected distal to a urolithiasis obstruction in cats. Healthy ureters (total length 9.88 ± 0.38 cm) developed adventitia composed of collagen fibers (ADCF), containing a longitudinal muscular layer, toward the distal segment. The healthy ureter was the smallest in the middle segment (4.71-6.90 cm from the urinary bladder) with significantly decreased luminal and submucosal areas compared to those in the proximal segment. Diseased cats exhibited a high incidence of calcium oxalate urolithiasis with renal dysfunction, regardless of age, sex, and body size. Diseased ureters showed increased perimeters, inflammation, and decreased nerves in ADCF. Collagen fibers were increased in the submucosal area, intermuscular spaces, and ADCF, particularly near the obstructed lesion. The mean resected ureter length was 5.66 ± 0.49 cm, suggesting a high obstruction risk in the middle segment. The middle segment also increased the cross-sectional area of the ureter and ADCF, regardless of the distance from the obstructed lesion. The ureters in several cases either lacked the transitional epithelium, or exhibited transitional epithelial hyperplasia, and some of these formed the mucosal folds. In conclusion, we demonstrated the following characteristics and histopathological features of cat ureters: decreases in the ureter size, lumen area, and submucosa area from proximal to middle segment in healthy; ADCF changes in urolithiasis, including increased connective tissues with inflammation and decreased nerves. These data are important to understand the pathogenesis of feline ureteral obstruction.
• Modified foreign body reaction to silicone imbedded in subcutaneous tissues by different mouse systemic immune conditions
  Tomohiro Yamakawa; Osamu Ichii; Teppei Nakamura; Takashi Namba; Yaser Hosny Ali Elewa; Md. Abdul Masum; Yuki Otani; Takanori Nishimura; Yasuhiro Kon
  Journal of Biomedical Materials Research Part A, 110, 12, 1921, 1931, Jun. 2022, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Foreign body reaction (FBR) causes unexpected adverse effects due to implanted materials in humans and animals. Inflammation and subsequent fibrosis during FBR seems to be affected by recipient immunity, such as the balance of T helper (Th) response that has the potential to regulate FBR-related macrophage function. Here, the immunological effects of FBR on subcutaneously imbedded silicone tubes (ST) at 8 weeks were investigated histologically by comparing Th1-biased C57BL/6N, Th2-biased MRL/MpJ, and autoimmune disease-prone MRL/MpJ-Faslpr/lpr . Tissue surrounding ST (TSS) was analyzed at day (D) 7 and 14 (reaction phase) or D35 (stability phase) after surgery. In all strains, the TSS was composed of a thin layer (TL) containing fibrous tissues and loose connective tissues formed outside the TL. Few lymphocytes and mast cells, several neutrophils, and numerous macrophages infiltrated the TSS. Active vascularization was observed at D14 in all strains. For the examined indices, M1-type macrophage density in the TSS of C57BL/6N mice was significantly higher at D14 compared to other strains. No significant strain difference relating to M2-type macrophages was detected, suggesting the effects of Th1-biased immunity on FBR-related inflammation. Collagen fibers in the TSS increased in density and became stable with age in all strains. In particular, MRL/MpJ-Faslpr/lpr showed progressive fibrotic features. Serum autoantibody levels in MRL/MpJ-Faslpr/lpr mice were inversely correlated with M1-type macrophage density. These data from MRL/MpJ-Faslpr/lpr mice suggested modifications of FBR-related inflammation and fibrosis by autoimmune abnormalities. The results provide crucial insights into the pathological modification of FBR by recipient immunity and emphasize its clinicopathological importance in humans and animals.
• The Ameliorative Effect of Dexamethasone on the Development of Autoimmune Lung Injury and Mediastinal Fat-Associated Lymphoid Clusters in an Autoimmune Disease Mouse Model
  Yaser Elewa; Md Abdul Masum; Sherif Mohamed; Md Rashedul Islam; Teppei NAKAMURA; Osamu Ichii; Yasuhiro Kon
  International Journal of Molecular Sciences, 23, 8, 4449, 4449, {MDPI} {AG}, Apr. 2022, [Peer-reviewed], [International Magazine]
  English, Scientific journal, In our previous study, we revealed the ameliorative therapeutic effect of dexamethasone (Dex) for Lupus nephritis lesions in the MRL/MpJ-Fas lpr/lpr (Lpr) mouse model. The female Lpr mice developed a greater number of mediastinal fat-associated lymphoid clusters (MFALCs) and inflammatory lung lesions compared to the male mice. However, the effect of Dex, an immunosuppressive drug, on both lung lesions and the development of MFALCs in Lpr mice has not been identified yet. Therefore, in this study, we compared the development of lung lesions and MFALCs in female Lpr mice that received either saline (saline group "SG") or dexamethasone (dexamethasone group "DG") in drinking water as a daily dose along with weekly intraperitoneal injections for 10 weeks. Compared to the SG group, the DG group showed a significant reduction in the levels of serum anti-dsDNA antibodies, the size of MFALCs, the degree of lung injury, the area of high endothelial venules (HEVs), and the number of proliferating and immune cells in both MFALCs and the lungs. A significant positive correlation was observed between the size of MFALCs and the cellular aggregation in the lungs of Lpr mice. Therefore, this study confirmed the ameliorative effect of Dex on the development of lung injury and MFALCs via their regressive effect on both immune cells' proliferative activity and the development of HEVs. Furthermore, the reprogramming of MFALCs by targeting immune cells and HEVs may provide a therapeutic strategy for autoimmune-disease-associated lung injury.
• Cotton rats ( Sigmodon hispidus ) with a high prevalence of hydrocephalus without clinical symptoms
  Daisuke Kondoh; Teppei Nakamura; Erika Tsuji; Marina Hosotani; Osamu Ichii; Takao Irie; Takashi Mishima; Ken‐ichi Nagasaki; Yasuhiro Kon
  Neuropathology, 42, 1, 16, 27, Wiley, Feb. 2022, [Peer-reviewed], [Lead author, Corresponding author]
  Scientific journal
• Close Association between Altered Urine–Urothelium Barrier and Tertiary Lymphoid Structure Formation in the Renal Pelvis during Nephritis
  Osamu Ichii; Marina Hosotani; Md. Abdul Masum; Taro Horino; Yuki Otani; Takashi Namba; Teppei Nakamura; Elewa Yaser Hosny Ali; Yasuhiro Kon
  Journal of the American Society of Nephrology, 33, 1, 88, 107, Jan. 2022, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Background: Kidneys with chronic inflammation develop tertiary lymphoid structures (TLSs). Infectious pyelonephritis is characterized by renal pelvis (RP) inflammation. However, the pathological features of TLSs, including their formation and association with non-infectious nephritis, are unclear. Methods: RPs from humans and mice that were healthy or had non-infectious chronic nephritis, were analyzed for TLS development, and the mechanism of TLS formation investigated using urothelium or lymphoid structure cultures. Results: Regardless of infection, TLSs in the RP, termed urinary tract-associated lymphoid structures (UTALSs), formed in humans and mice with chronic nephritis. Moreover, urine played a unique role in UTALS formation. Specifically, we identified urinary IFN-γ as a candidate factor affecting urothelial barrier integrity because it alters occludin expression. In a nephritis mouse model, urine leaked from the lumen of the RP into the parenchyma. In addition, urine immunologically stimulated UTALS-forming cells via cytokine (IFN-γ, TNF-α) and chemokine (CXCL9, CXCL13) production. CXCL9 and CXCL13 were expressed in UTALS stromal cells and urine stimulation specifically induced CXCL13 in cultured fibroblasts. Characteristically, type XVII collagen (BP180), a candidate autoantigen of bullous pemphigoid, was ectopically localized in the urothelium covering UTALSs and associated with UTALS development by stimulating CXCL9 or IL-22 induction via the TNF-α/FOS/JUN pathway. Notably, UTALS development indices were positively correlated with chronic nephritis development. Conclusion: TLS formation in the RP is possible and altered urine-urothelium barrier-basedUTALS formation may represent a novel mechanism underlying the pathogenesis of chronic nephritis, regardless of urinary tract infection.
• Novel polychrome staining distinguishing osteochondral tissue and bone cells in decalcified paraffin sections
  Teppei Nakamura; Kanako Sumi; Erika Tsuji; Marina Hosotani; Takashi Namba; Osamu Ichii; Takao Irie; Ken-ichi Nagasaki; Yasuhiro Kon; Takashi Mishima; Tomoji Yoshiyasu
  Cell and Tissue Research, 385, 3, 727, 737, Springer Science and Business Media {LLC}, 19 Aug. 2021, [Peer-reviewed], [Lead author, Corresponding author], [International Magazine]
  English, Scientific journal, The bone is a dynamic and metabolically active organ in which growth and resorption of the osteochondral matrix is orchestrated by osteoblasts and osteoclasts. For decalcified paraffin-embedded specimens, decalcifying agents alter the staining intensity, and excess decalcification interferes with bone staining. Robust bone staining methods independent of the decalcification conditions and animal species are lacking. In this study, we have developed a novel polychrome staining method, named JFRL staining, which stains the components of osteochondral tissue in different colors. With this staining we could visualize the hyaline cartilage as blue by alcian blue, osteoid as red by picrosirius red, and mineralized bone as green by picro-light green SF or picro-naphthol green B and easily distinguished osteoblasts, osteocytes, and osteoclasts. In mineralized bone, this staining revealed the obvious lamellar structures and woven bone. Notably, this staining was independent of the decalcification conditions and experimental animal species examined. To verify the usefulness of JFRL staining, we observed cotton rat tail which has shorter length and shows a false autotomy. The caudal vertebrae were normally developed via endochondral ossification without a fracture plane. At 6 months of age, the number of chondrocytes declined and the hypertrophic zone was absent at the epiphyseal plate, which might reflect the shorter tail. In conclusion, JFRL staining is the first method to simultaneously distinguish osteochondral matrix and bone cells in one section regardless of decalcifying conditions. This robust staining will provide new information for a wide number of biomedical fields, including bone development, physiology, and pathology.
• Altered Renal Pathology in an Autoimmune Disease Mouse Model After Induction of Diabetes Mellitus.
  Shiori Hiramatsu; Osamu Ichii; Takashi Namba; Yuki Otani; Teppei Nakamura; Md Abdul Masum; Yaser Hosny Ali Elewa; Yasuhiro Kon
  Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada, 27, 4, 897, 909, Aug. 2021, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Diabetes mellitus (DM) is a predisposing factor for renal disorder progression and is referred to as diabetic kidney disease (DKD). However, there are no reports of DKD with an underlying autoimmune disorder. In this study, we compared the pathophysiological changes caused by DM induction after streptozotocin (STZ) injection in comparison with that in a control group receiving citrate buffer (CB) in the autoimmune disease model mice “BXSB/MpJ-Yaa” (Yaa) and the wild-type strain BXSB/MpJ. Both strains showed hyperglycemia after 12 weeks of STZ injection. Interestingly, the Yaa group developed membranous and proliferative glomerulonephritis, which tended to be milder glomerular lesions in the STZ group than in the CB group, as indicated by a decreased mesangial area and ameliorated albuminuria. Statistically, the indices for hyperglycemia and autoimmune abnormalities were negatively and positively correlated with the histopathological parameters for mesangial matrix production and glomerular proliferative lesions, respectively. STZ treatment induced renal tubular anisonucleosis and dilations in both strains, and they were more severe in Yaa. Significantly decreased cellular infiltration was observed in the Yaa group compared to the CB group. Thus, in DKD related to autoimmune nephritis, hyperglycemia modifies its pathology by decreasing the mesangial area and interstitial inflammation and aggravating renal tubular injury.
• Compartmentalization of interleukin 36 subfamily according to inducible and constitutive expression in the kidneys of a murine autoimmune nephritis model
  Takashi Namba; Osamu Ichii; Teppei Nakamura; Md. Abdul Masum; Yuki Otani; Marina Hosotani; Yaser Hosny Ali Elewa; Yasuhiro Kon
  Cell and Tissue Research, Jul. 2021, [Peer-reviewed]
  English, Scientific journal
• Possible Crosstalk of the Immune Cells within the Lung and Mediastinal Fat-Associated Lymphoid Clusters in the Acute Inflammatory Lung Asthma-Like Mouse Model
  Yaser Elewa; Mahmoud Mansour Abd Elwakil; Osamu Ichii; Teppei NAKAMURA; Sherif Kh. A. Mohamed; Yasuhiro Kon
  International Journal of Molecular Sciences, 22, 13, 6878, 6878, {MDPI} {AG}, Jun. 2021, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Recently, we clarified the function of mediastinal fat-associated lymphoid clusters (MFALCs) in the progression of several respiratory diseases. However, their role has not yet been identified in the lung asthmatic condition. Hence, we compared the immune cells in lung and MFALCs of C57BL/6N mice on days 3 and 7 following intranasal instillation of either papain (papain group "PG") or phosphate buffer saline (PBS) (vehicle group "VG"). The PG showed significantly prominent MFALCs, numerous goblet cells (GCs), and higher index ratios of different immune cells (macrophages, natural helper cells (NHC), B- and T-lymphocytes) within the MFALCs and lung than in the VG on both days 3 and 7. Interestingly, a tendency of decreased size of MFALCs and a significant reduction in the number of GCs and immune cells were observed within the MFALCs and lung in the PG on day 7 than on day 3. Furthermore, the quantitative parameters of these immune cells in MFALCs were significantly and positively correlated with the size of MFALCs and immune cells in the lung. This suggested that the possible crosstalk between immune cells within MFALCs and the lung could play a critical role in the progression and recovery of the acute inflammatory lung asthma.
• Comparison of Ovarian Morphology and Follicular Disturbances between Two Inbred Strains of Cotton Rats (Sigmodon hispidus)
  Md Rashedul Islam; Osamu Ichii; Teppei NAKAMURA; Takao Irie; Akio Shinohara; Masum MA; Yuki Otani; Takashi Namba; Tsolmon Chuluunbaatar; Yaser Elewa; Yasuhiro Kon
  Animals, 11, 6, 1768, 1768, {MDPI} {AG}, Jun. 2021, [Peer-reviewed]
  Scientific journal, Most mammalian ovarian follicles contain only a single oocyte having a single nucleus. However, two or more oocytes and nuclei are observed within one follicle and one oocyte, respectively, in several species, including cotton rat (CR, Sigmodon hispidus). The present study compared ovarian histology, focusing on folliculogenesis, between two inbred CR strains, HIS/Hiph and HIS/Mz. At 4 weeks of age, ovarian sections from both the strains were analyzed histologically. Multi-oocyte follicles (MOFs) and double-nucleated oocytes (DNOs) were observed in all stages of developing follicles in HIS/Hiph, whereas HIS/Mz had MOFs up to secondary stages and lacked DNOs. The estimated total follicles in HIS/Mz were almost half that of HIS/Hiph, but interstitial cells were well developed in HIS/Mz. Furthermore, immunostaining revealed no clear strain differences in the appearance of oocytes positive for Ki67, PCNA, and p63 in MOF or DNOs; no cell death was observed in these oocytes. Ultrastructural analysis revealed more abundant mitochondrial clouds in oocytes of HIS/Hiph than HIS/Mz. Thus, we clarified the strain differences in the CR ovary. These findings indicate that early events during folliculogenesis affect the unique ovarian phenotypes found in CRs, including MOFs or DNOs, and their strain differences.
• Unique histological features of the tail skin of cotton rat (Sigmodon hispidus) related to caudal autotomy
  Marina Hosotani; Teppei Nakamura; Osamu Ichii; Takao Irie; Yuji Sunden; Yaser Hosny Ali Elewa; Takafumi Watanabe; Hiromi Ueda; Takashi Mishima; Yasuhiro Kon
  Biology Open, 10, 2, The Company of Biologists, 15 Feb. 2021, [Peer-reviewed], [Lead author, Corresponding author], [International Magazine]
  English, Scientific journal, Caudal autotomy in rodents is an evolutionarily acquired phenomenon enabling escape from predators, by discarding the tail skin after traumatic injuries. The histological mechanisms underlying caudal autotomy seem to differ among species. Cotton rats (Sigmodon hispidus), which are important laboratory rodents for human infectious diseases, possess a fragile tail. In this study, we compared the tail histology of cotton rats with that of laboratory rats (Rattus norvegicus), which have no fragility on their tail, to elucidate the process of rodent caudal autotomy. First, the cotton rats developed a false autotomy characterized by loss of the tail sheath with the caudal vertebrae remaining without tail regeneration. Second, we found the fracture plane was continuous from the interscale of the tail epidermis to the dermis, which was lined with an alignment of E-cadherin+ cells. Third, we found an obvious cleavage plane between the dermis and subjacent tissues of the cotton-rat tail, where the subcutis was composed of looser, finer, and fragmented collagen fibers compared with those of the rat. Additionally, the cotton-rat tail was easily torn, with minimum bleeding. The median coccygeal artery of the cotton rat had a thick smooth muscle layer, and its lumen was filled with the peeled intima with fibrin coagulation, which might be associated with reduced bleeding following caudal autotomy. Taken together, we reveal the unique histological features of the tail relating to the caudal autotomy process in the cotton rat, and provide novel insights to help clarify the rodent caudal autotomy mechanism.
• Castrated autoimmune glomerulonephritis mouse model shows attenuated glomerular sclerosis with altered parietal epithelial cell phenotype
  Yuki Otani; Osamu Ichii; Md. Abdul Masum; Takashi Namba; Teppei Nakamura; Yasuhiro Kon
  Experimental Biology and Medicine, 246, 11, 1318, 1329, {SAGE} Publications, Feb. 2021, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Sex hormones help in maintaining proper immunity as well as renal homeostasis in mammals, and these multi-functional properties characterize the onset of sex-dependent diseases. To clarify the contribution of sex hormones to autoimmune disease-related renal pathogenesis, BXSB/MpJ-Yaa was investigated as a murine autoimmune glomerulonephritis model. BXSB/MpJ-Yaa and its wild-type, BXSB/MpJ-Yaa+ were castrated or sham-operated at three weeks and examined until six months of age. Both castrated strains showed significantly lower serum testosterone levels and body weights than sham-operated mice. Castration did not change the disease phenotypes in BXSB/MpJ-Yaa+. At three months, both sham-operated and castrated BXSB/MpJ-Yaa manifested splenomegaly, autoantibody production, and glomerulonephritis, and castrated BXSB/MpJ-Yaa tended to show heavier spleen weights than the sham-operated group. At six months, both the treated BXSB/MpJ-Yaa showed equivalent autoimmune disease conditions; however, castrated mice clearly showed milder glomerular sclerotic lesions than the sham-operated groups. Urinary albumin excretion in castrated BXSB/MpJ-Yaa was significantly milder than in sham-operated mice at four months, but those of both the treated BXSB/MpJ-Yaa were comparable at six months. The examined renal histopathological indices in parietal epithelial cells were remarkably altered by castration. Briefly, castration decreased the height of parietal epithelial cells and total parietal epithelial cell number in BXSB/MpJ-Yaa at six months. For immunostaining, parietal epithelial cells facing the injured glomeruli of BXSB/MpJ-Yaa expressed CD44, an activated parietal epithelial cell marker, and CD44-positive parietal epithelial cells showed nuclear localization of the androgen receptor and proliferation marker Ki67. CD44- or Ki67-positive parietal epithelial cells were significantly fewer in castrated group than in sham-operated BXSB/MpJ-Yaa at six months. Further, quantitative indices for CD44-positive parietal epithelial cell number and frequency in renal corpuscles positively correlated with glomerular sclerotic severity in BXSB/MpJ-Yaa. In conclusion, androgen seemed to have an effect on both systemic immunity and renal morpho-function; however, the effect on the latter could be more clearly observed in BXSB/MpJ-Yaa, as parietal epithelial cell activation resulted in glomerular sclerosis.
• Dual Effect of Bleomycin on Histopathological Features of Lungs and Mediastinal Fat-Associated Lymphoid Clusters in an Autoimmune Disease Mouse Model.
  Yaser Hosny Ali Elewa; Osamu Ichii; Teppei Nakamura; Yasuhiro Kon
  Frontiers in immunology, 12, 665100, 665100, 2021, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Mediastinal fat-associated lymphoid clusters (MFALCs) are novel immune clusters that function in the pathogenesis of bleomycin (BLM)-induced pneumonitis in a C57BL/6 mouse model. However, we lack literature on the effects of BLM in an autoimmune disease mouse model (AIDM). In the present study, BLM sulfate (BLM group) or phosphate-buffered saline (PBS group) were intranasally administered in BXSB/MpJ-Yaa (Yaa) AIDM and its wild-type strains (BXSB/MpJ "BXSB") and the histopathology of MFALCs and lungs were examined on days 7 and 21 days. Immunohistochemical analysis was performed to detect lymphatic vessels (LVs), high endothelial venules (HEVs), proliferating, and immune cells. Furthermore, the mRNA expression of Yaa locus genes (TLR7, TLR8, Arhgap6, Msl3, and Tceanc) was detected in the lung tissues. Here, we show a dual effect of BLM on intra-thoracic immune hemostasis among Yaa AIDM and its corresponding wild-type strain (BXSB mice). The BLM group of BXSB mice displayed significantly higher values of lung injury scores (LIS) and size of MFALCs as compared with the corresponding PBS group. However, an opposite effect was detected in Yaa mice. Furthermore, Yaa mice displayed decreased serum autoantibody titers and downregulated expression of TLR7, TLR8, Msl3, and Tceanc in the lungs following BLM administration, especially on day 21. Interestingly, significant positive correlations were detected in both strains between the LIS and the size of MFALCs, LVs, HEVs, and proliferating cells. Conclusively, our findings revealed a crucial function of HEVs on the extent of lung injury and the development of MFALCs in BLM-administered Yaa AIDM and control BXSB mice with dual effects. Moreover, our data suggest that down regulation of Yaa locus genes could contribute as an important attributing factor leading to decrease in the degree of autoimmunity and lung injury in AIDM. Therefore, we suggest that genetic background contributes to BLM diversity among AIDM and the wild-type strain. Targeting some genes or venules could provide novel therapeutic approaches for some autoimmune-associated respiratory diseases via controlling the MFALCs development.
• Developmental Changes of the Ovary in Neonatal Cotton Rat (Sigmodon hispidus)
  Md. Rashedul Islam; Osamu Ichii; Teppei Nakamura; Takao Irie; Md. Abdul Masum; Yuki Otani; Takashi Namba; Tsolmon Chuluunbaatar; Yaser Hosny Ali Elewa; Yasuhiro Kon
  Frontiers in Physiology, 11, Frontiers Media {SA}, Jan. 2021, [Peer-reviewed]
  Scientific journal
• Unique Running Pattern and Mucosal Morphology Found in the Colon of Cotton Rats
  Tsolmon Chuluunbaatar; Osamu Ichii; Teppei Nakamura; Takao Irie; Takashi Namba; Md Rashedul Islam; Yuki Otani; Md Abdul Masum; Yuko Okamatsu-Ogura; Yaser Hosny Ali Elewa; Yasuhiro Kon
  Frontiers in Physiology, 11, Frontiers Media {SA}, Oct. 2020, [Peer-reviewed]
  Scientific journal
• Spatiotemporal histological changes observed in mouse subcutaneous tissues during the foreign body reaction to silicone
  Sao Oe; Md. Abdul Masum; Osamu Ichii; Takanori Nishimura; Teppei Nakamura; Takashi Namba; Yuki Otani; Yasuhide Nakayama; Yaser Hosny Ali Elewa; Yasuhiro Kon
  Journal of Biomedical Materials Research Part A, 109, 7, 1220, 1231, Wiley, Oct. 2020, [Peer-reviewed], [International Magazine]
  English, Scientific journal, We investigated spatiotemporal changes in host tissues during foreign body reactions. Silicone tube was subcutaneously embedded into ICR mice, and tissue surrounding silicone (TSS) was observed at 2, 7, 14, 21, 28, 43, and 70 days (D) postsurgery. The thin layer (TL) and loose connective tissues (LCTs) (inside and outside the TSS) developed until D21 and densified afterward. Neutrophils infiltrated the TSS until D14 and formed neutrophil extracellular traps (NETs) in the TL during D7-21. In the LCTs, mast cell counts increased until D21, and macrophage numbers peaked at D14. Several macrophages showed LYVE-1 expression, supporting a tissue-remodeling role. Developmental indices of collagen fibers (CFs) and reticular fibers (RFs) increased during D2-21. NETs, but not neutrophils, were detected after D28. Mast cell numbers peaked at D43 and were maintained until D70. Myofibroblasts consistently localized to the TL from D14. During D21-28, the area of connective tissue (CNT), and CFs and RFs decreased and increased, respectively, and both remained constant during D28-70. The CF density remained constant from D21 and increased at D70. Thus, TSS showed two phases: inflammation and CNT development (D2-21), and inflammation convergence and CNT stabilization (D28-70). These results provide insights into foreign body reactions in clinical cases.
• Anatomy and histology of the foramen of ovarian bursa opening to the peritoneal cavity and its changes in autoimmune disease‐prone mice
  Marina Hosotani; Osamu Ichii; Teppei Nakamura; Takashi Namba; Md. Rashedul Islam; Yaser Hosny Ali Elewa; Takafumi Watanabe; Hiromi Ueda; Yasuhiro Kon
  Journal of Anatomy, 238, 1, 73, 85, Wiley, Sep. 2020, [Peer-reviewed]
  Scientific journal
• BXSB/MpJ-Yaa mouse model of systemic autoimmune disease shows increased apoptotic germ cells in stage XII of the seminiferous epithelial cycle
  Yuki Otani; Osamu Ichii; Md. Abdul Masum; Junpei Kimura; Teppei Nakamura; Yaser Hosny Ali Elewa; Yasuhiro Kon
  Cell and Tissue Research, Springer Science and Business Media {LLC}, 04 Apr. 2020, [Peer-reviewed]
  Scientific journal
• Altered ciliary morphofunction in the oviductal infundibulum of systemic autoimmune disease-prone MRL/MpJ-Faslpr/lpr mice
  Marina Hosotani; Osamu Ichii; Teppei Nakamura; Md. Abdul Masum; Yuki Otani; Yaser Hosny Ali Elewa; Yasuhiro Kon
  Cell and Tissue Research, Springer Science and Business Media {LLC}, 05 Feb. 2020, [Peer-reviewed]
  Scientific journal
• Pathological Alternations of Mediastinal Fat-Associated Lymphoid Cluster and Lung in a Streptozotocin-Induced Diabetic Mouse Model
  Yaser H.A. Elewa; Osamu Ichii; Teppei Nakamura; Yasuhiro Kon
  Microscopy and Microanalysis, 27, 1, 1, 14, Cambridge University Press ({CUP}), 2020, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Diabetes is a devastating global health problem and is considered a predisposing factor for lung injury progression. Furthermore, previous reports of the authors revealed the role of mediastinal fat-associated lymphoid clusters (MFALCs) in advancing respiratory diseases. However, no reports concerning the role of MFALCs on the development of lung injury in diabetes have been published. Therefore, this study aimed to examine the correlations between diabetes and the development of MFALCs and the progression of lung injury in a streptozotocin-induced diabetic mouse model. Furthermore, immunohistochemical analysis for immune cells (CD3+ T-lymphocytes, B220+ B-lymphocytes, Iba1+ macrophages, and Gr1+ granulocytes), vessels markers (CD31+ endothelial cells and LYVE-1+ lymphatic vessels "LVs"), and inflammatory markers (TNF-α and IL-5) was performed. In comparison to the control group, the diabetic group showed lung injury development with a significant increase in MFALC size, immune cells, LVs, and inflammatory marker, and a considerable decrease of CD31+ endothelial cells in both lung and MFALCs was observed. Furthermore, the blood glucose level showed significant positive correlations with MFALCs size, lung injury, immune cells, inflammatory markers, and LYVE-1+ LVs in lungs and MFALCs. Thus, we suggest that the development of MFALCs and LVs could contribute to lung injury progression in diabetic conditions.
• Unique morphological characteristics in the ovary of cotton rat (Sigmodon hispidus)
  Md. Rashedul ISLAM; Osamu ICHII; Teppei NAKAMURA; Takao IRIE; Md. Abdul MASUM; Marina HOSOTANI; Yuki OTANI; Yaser Hosny Ali ELEWA; Yasuhiro KON
  Journal of Reproduction and Development, Japanese Society of Animal Reproduction, 2020, [Peer-reviewed]
  Scientific journal
• Age-related changes in bone morphology, function, and cell populations in inbred C57BL/6N mice
  Takashi Namba; Osamu Ichii; Teppei Nakamura; Md. Abdul Masum; Yuki Otani; Saori Otsuka-Kanazawa; Yaser Elewa; Yasuhiro Kon
  Japanese Journal of Veterinary Research, 67, 4, 313, 317, Nov. 2019, [Peer-reviewed], [Domestic magazines]
  English, Scientific journal
• Age-related glomerular lesions with albuminuria in male cotton rats
  Osamu Ichii; Teppei Nakamura; Takao Irie; Yuki Otani; Marina Hosotani; Md. Abdul Masum; Rashedul Md. Islam; Taro Horino; Yuji Sunden; Yaser Hosny Ali Elewa; Yasuhiro Kon
  Histochemistry and Cell Biology, Springer Science and Business Media {LLC}, Oct. 2019, [Peer-reviewed]
  Scientific journal
• Slc:Wistar/ST rats develop unilateral thyroid dysgenesis: A novel animal model of thyroid hemiagenesis
  Teppei Nakamura; Michael Schubert; Osamu Ichii; Yuji Sunden; Yaser Hosny Ali Elewa; Tomoji Yoshiyasu; Hideki Hattori; Osamu Tatsumi; Yasuhiro Kon; Ken-ichi Nagasaki
  PLOS ONE, 29 Aug. 2019, [Peer-reviewed], [Lead author, Corresponding author]
  Scientific journal
• Immune-associated renal disease found in caspase 3-deficient mice
  Takashi Suzuki; Osamu Ichii; Teppei Nakamura; Taro Horino; Yaser Hosny Ali Elewa; Yasuhiro Kon
  Cell and Tissue Research, Springer Science and Business Media {LLC}, Aug. 2019, [Peer-reviewed]
  Scientific journal
• Histopathological features of the proper gastric glands in FVB/N-background mice carrying constitutively-active aryl-hydrocarbon receptor
  Ai Dantsuka; Osamu Ichii; Annika Hanberg; Yaser Hosny Ali Elewa; Saori Otsuka-Kanazawa; Teppei Nakamura; Yasuhiro Kon
  BMC Gastroenterology, 19, 1, Springer Science and Business Media {LLC}, Jun. 2019, [Peer-reviewed]
  Scientific journal
• Altered morpho-functional features of bones in autoimmune disease-prone BXSB/MpJ-Yaa mice
  Takashi Namba; Osamu Ichii; Teppei Nakamura; Md Abdul Masum; Yuki Otani; Saori Otsuka-Kanazawa; Yaser Hosny Ali Elewa; Yasuhiro Kon
  Experimental Biology and Medicine, 244, 5, 333, 343, {SAGE} Publications, 28 Apr. 2019, [Peer-reviewed]
  Scientific journal
• Cotton rat (Sigmodon hispidus) develops metabolic disorders associated with visceral adipose inflammation and fatty pancreas without obesity
  Teppei Nakamura; Osamu Ichii; Takao Irie; Hirokazu Kouguchi; Kozue Sotozaki; Masataka Chihara; Yuji Sunden; Ken-ichi Nagasaki; Osamu Tatsumi; Yaser Hosny Ali Elewa; Yasuhiro Kon
  Cell and Tissue Research, 375, 2, 483, 492, Springer Science and Business Media {LLC}, 28 Feb. 2019, [Peer-reviewed], [Lead author]
  Scientific journal
• Slc:Hartley guinea pigs frequently possess duplication of the caudal vena cava
  Teppei NAKAMURA; Miyuki NORIMURA; Kanako SUMI; Osamu ICHII; Yaser Hosny Ali ELEWA; Yasuhiro KON; Osamu TATSUMI; Hideki HATTORI; Tomoji YOSHIYASU; Ken-ichi NAGASAKI
  Experimental Animals, Japanese Association for Laboratory Animal Science, 2019, [Peer-reviewed], [Lead author, Corresponding author]
  Scientific journal
• Molecular characterization of three Sarcocystis spp. from wild sika deer (Cervus nippon yesoensis) in Hokkaido, Japan
  Takao Irie; Osamu Ichii; Teppei Nakamura; Tetsuya Ikeda; Takuya Ito; Akiko Yamazaki; Shinji Takai; Kinpei Yagi
  Veterinary Parasitology: Regional Studies and Reports, 18, 100327, 100327, Elsevier {BV}, 2019, [Peer-reviewed]
  Scientific journal
• Modified scanning electron microscopy reveals pathological crosstalk between endothelial cells and podocytes in a murine model of membranoproliferative glomerulonephritis
  Md. Abdul Masum; Osamu Ichii; Yaser Hosny Ali Elewa; Teppei Nakamura; Yuki Otani; Marina Hosotani; Yasuhiro Kon
  Scientific Reports, 8, 1, Springer Nature, Dec. 2018, [Peer-reviewed]
  Scientific journal
• Urinary Exosome-Derived microRNAs Reflecting the Changes in Renal Function in Cats
  Osamu Ichii; Hiroshi Ohta; Taro Horino; Teppei Nakamura; Marina Hosotani; Tatsuya Mizoguchi; Keitaro Morishita; Kensuke Nakamura; Noboru Sasaki; Mitsuyoshi Takiguchi; Ryo Sato; Kazuhisa Oyamada; Yaser Hosny Ali Elewa; Kon Yasuhiro
  Frontiers in Veterinary Science, 5, Frontiers Media {SA}, Nov. 2018, [Peer-reviewed]
  Scientific journal
• Restricted localization of ultimobranchial body remnants and parafollicular cells in the one-humped camel (Camelus dromedarius)
  Teppei NAKAMURA; Yaser Hosny Ali ELEWA; Osamu ICHII; Marina HOSOTANI; Wael A. M. GHONIMI; Osamu TATSUMI; Ken-ichi NAGASAKI; Yasuhiro KON
  Journal of Veterinary Medical Science, 80, 9, 1368, 1372, Japanese Society of Veterinary Science, Sep. 2018, [Peer-reviewed], [Lead author]
  Scientific journal
• Abnormal Morphology of Distal Tubular Epithelial Cells Is Regulated by Genetic Factors Derived from Mouse Chromosome 12
  Osamu Ichii; Teppei Nakamura; Taro Horino; Akira Yabuki; Yaser H.A. Elewa; Yasuhiro Kon
  The American Journal of Pathology, 188, 9, 2120, 2138, Elsevier {BV}, Sep. 2018, [Peer-reviewed]
  Scientific journal
• Cotton rats (Sigmodon hispidus) possess pharyngeal pouch remnants originating from different primordia.
  Nakamura T; Ichii O; Irie T; Mizoguchi T; Shinohara A; Kouguchi H; Sunden Y; Otsuka-Kanazawa S; Ali Elewa YH; Koshimoto C; Nagasaki KI; Kon Y
  Histology and histopathology, Jun. 2018, [Peer-reviewed], [Lead author]
  Scientific journal
• Ovarian mast cells migrate toward ovary-fimbria connection in neonatal MRL/MpJ mice
  Teppei Nakamura; Gao-Feng Qiu; Masataka Chihara; Osamu Ichii; Saori Otsuka-Kanazawa; Ken-ichi Nagasaki; Yaser Hosny Ali Elewa; Osamu Tatsumi; Yasuhiro Kon
  PLOS ONE, 23 Apr. 2018, [Peer-reviewed], [Lead author]
  Scientific journal
• Close pathological correlations between chronic kidney disease and reproductive organ-associated abnormalities in female cotton rats
  Osamu Ichii; Teppei Nakamura; Takao Irie; Hirokazu Kouguchi; Kozue Sotozaki; Taro Horino; Yuji Sunden; Yaser Hosny Ali Elewa; Yasuhiro Kon
  Experimental Biology and Medicine, 243, 5, 418, 427, {SAGE} Publications, 07 Mar. 2018, [Peer-reviewed]
  Scientific journal
• Histopathological Correlations between Mediastinal Fat-Associated Lymphoid Clusters and the Development of Lung Inflammation and Fibrosis following Bleomycin Administration in Mice
  Yaser Hosny Ali Elewa; Osamu Ichii; Kensuke Takada; Teppei Nakamura; Md. Abdul Masum; Yasuhiro Kon
  Frontiers in Immunology, 9, Frontiers Media {SA}, Feb. 2018, [Peer-reviewed]
  Scientific journal
• Overexpression of toll-like receptor 9 correlates with podocyte injury in a murine model of autoimmune membranoproliferative glomerulonephritis
  Md. Abdul Masum; Osamu Ichii; Yaser Hosny Ali Elewa; Teppei Nakamura; Yuki Otani; Marina Hosotani; Yasuhiro Kon
  Autoimmunity, 1, 13, Informa {UK} Limited, 2018, [Peer-reviewed]
  Scientific journal
• Morphofunctional analysis of antigen uptake mechanisms following sublingual immunotherapy with beads in mice
  Yaser Hosny Ali Elewa; Tatsuya Mizoguchi; Osamu Ichii; Teppei Nakamura; Yasuhiro Kon; Heinz Fehrenbach
  PLOS ONE, 13, 12, e0201330, Public Library of Science ({PLoS}), 2018, [Peer-reviewed]
  Scientific journal
• MRL/MpJ mice produce more oocytes and exhibit impaired fertilisation and accelerated luteinisation after superovulation treatment
  Marina Hosotani; Osamu Ichii; Teppei Nakamura; Md Abdul Masum; Yuki Otani; Saori Otsuka-Kanazawa; Yaser H. A. Elewa; Yasuhiro Kon
  Reproduction, Fertility and Development, {CSIRO} Publishing, 2018, [Peer-reviewed]
  Scientific journal
• IL-36α Regulates Tubulointerstitial Inflammation in the Mouse Kidney
  Osamu Ichii; Junpei Kimura; Tadashi Okamura; Taro Horino; Teppei Nakamura; Hayato Sasaki; Yaser Hosny Ali Elewa; Yasuhiro Kon
  Frontiers in Immunology, 8, Frontiers Media {SA}, Oct. 2017, [Peer-reviewed]
  Scientific journal
• Local CD34-positive capillaries decrease in mouse models of kidney disease associating with the severity of glomerular and tubulointerstitial lesions
  Md Abdul Masum; Osamu Ichii; Yaser Hosny Ali Elewa; Teppei Nakamura; Yasuhiro Kon
  BMC Nephrology, 18, 1, Springer Nature, 04 Sep. 2017, [Peer-reviewed]
  Scientific journal
• Autoimmune abnormality affects ovulation and oocyte-pick-up in MRL/MpJ-Faslpr/lpr mice
  M Hosotani; O Ichii; T Nakamura; S O Kanazawa; Y Hosny Ali Elewa; Y Kon
  Lupus, 27, 1, 82, 94, {SAGE} Publications, May 2017, [Peer-reviewed]
  Scientific journal
• Urinary exosome-derived microRNAs reflecting the changes of renal function and histopathology in dogs
  Osamu Ichii; Hiroshi Ohta; Taro Horino; Teppei Nakamura; Marina Hosotani; Tatsuya Mizoguchi; Keitaro Morishita; Kensuke Nakamura; Yuki Hoshino; Satoshi Takagi; Noboru Sasaki; Mitsuyoshi Takiguchi; Ryo Sato; Kazuhisa Oyamada; Yasuhiro Kon
  Scientific Reports, 7, 40340, 40340, Springer Nature, 11 Jan. 2017, [Peer-reviewed]
  Scientific journal
• First molecular detection of Sarcocystis ovalis in the intestinal mucosa of a Japanese jungle crow ( Corvus macrorhynchos ) in Hokkaido, Japan
  Takao Irie; Tetsuya Ikeda; Teppei Nakamura; Osamu Ichii; Noriko Yamada; Takuya Ito; Akiko Yamazaki; Shinji Takai; Kinpei Yagi
  Veterinary Parasitology: Regional Studies and Reports, 10, 54, 57, Elsevier {BV}, 2017, [Peer-reviewed]
  Scientific journal
• Effects of a mixture of medetomidine, midazolam and butorphanol on anesthesia and blood biochemistry and the antagonizing action of atipamezole in hamsters
  Teppei NAKAMURA; Naoya KARAKIDA; Ai DANTSUKA; Osamu ICHII; Yaser Hosny Ali ELEWA; Yasuhiro KON; Ken-ichi NAGASAKI; Hideki HATTORI; Tomoji YOSHIYASU
  Journal of Veterinary Medical Science, 79, 7, 1230, 1235, Japanese Society of Veterinary Science, 2017, [Peer-reviewed], [Lead author, Corresponding author]
  Scientific journal
• Usefulness of an anesthetic mixture of medetomidine, midazolam, and butorphanol in cotton rats (Sigmodn hispidus).
  Nakamura T; Ichii O; Irie T; Hosotani M; Dantsuka A; Nakamura S; Sato S; Sotozaki K; Kouguchi H; Yoshiyasu T; Nagasaki KI; Kon Y
  The Japanese journal of veterinary research, Nov. 2016, [Peer-reviewed], [Lead author]
  Scientific journal
• Degenerative and regenerative features of myofibers differ among skeletal muscles in a murine model of muscular dystrophy
  Teppei Ikeda; Osamu Ichii; Saori Otsuka-Kanazawa; Teppei Nakamura; Yaser Hosny Ali Elewa; Yasuhiro Kon
  Journal of Muscle Research and Cell Motility, 37, 4-5, 153, 164, Springer Nature, Jul. 2016, [Peer-reviewed]
  Scientific journal
• Spatiotemporal distribution of extracellular matrix changes during mouse duodenojejunal flexure formation
  Sawa Onouchi; Osamu Ichii; Teppei Nakamura; Yaser Hosny Ali Elewa; Yasuhiro Kon
  Cell and Tissue Research, 365, 2, 367, 379, Springer Nature, 06 Apr. 2016, [Peer-reviewed]
  Scientific journal
• Female cotton rats (Sigmodon hispidus) develop chronic anemia with renal inflammation and cystic changes
  Osamu Ichii; Teppei Nakamura; Takao Irie; Hirokazu Kouguchi; Daisuke Nakamura; Saori Nakamura; Shinobu Sato; Keisuke Yokoyama; Taro Horino; Yuji Sunden; Yaser Hosny Ali Elewa; Yasuhiro Kon
  Histochemistry and Cell Biology, 146, 3, 351, 362, Springer Nature, Apr. 2016, [Peer-reviewed]
  Scientific journal
• MRL/MpJ mice show unique pathological features after experimental kidney injury.
  Shiozuru D; Ichii O; Kimura J; Nakamura T; Elewa YH; Otsuka-Kanazawa S; Kon Y
  Histology and histopathology, Feb. 2016, [Peer-reviewed]
  Scientific journal
• Hydronephrosis with ureteritis developed in C57BL/6N mice carrying the congenic region derived from MRL/MpJ-type chromosome 11
  Osamu Ichii; Masataka Chihara; Shin-Hyo Lee; Teppei Nakamura; Saori Otsuka-Kanazawa; Taro Horino; Yaser Hosny Ali Elewa; Yasuhiro Kon
  Autoimmunity, 50, 2, 114, 124, Informa {UK} Limited, 2016, [Peer-reviewed]
  Scientific journal
• Genetic factors derived from the MRL/MpJ mouse function to maintain the integrity of spermatogenesis after heat exposure
  M. Chihara; T. Nakamura; S. Otsuka-Kanazawa; O. Ichii; Y. H. A. Elewa; Y. Kon
  Andrology, 3, 5, 991, 999, Wiley-Blackwell, Aug. 2015, [Peer-reviewed]
  Scientific journal
• MRL/MpJ-Faslprmice show abnormalities in ovarian function and morphology with the progression of autoimmune disease
  Yuki Otani; Osamu Ichii; Saori Otsuka-Kanazawa; Masataka Chihara; Teppei Nakamura; Yasuhiro Kon
  Autoimmunity, 48, 6, 402, 411, Informa {UK} Limited, 10 Apr. 2015, [Peer-reviewed]
  Scientific journal
• Morphological characteristics observed during early follicular development in perinatal MRL/MpJ mice.
  Yamashita Y; Nakamura T; Otsuka-Kanazawa S; Ichii O; Kon Y
  The Japanese journal of veterinary research, Feb. 2015, [Peer-reviewed]
  Scientific journal
• Decreased miR-26a Expression Correlates with the Progression of Podocyte Injury in Autoimmune Glomerulonephritis
  Osamu Ichii; Saori Otsuka-Kanazawa; Taro Horino; Junpei Kimura; Teppei Nakamura; Manabu Matsumoto; Makoto Toi; Yasuhiro Kon; Maria Pia. Rastaldi
  PLoS ONE, 9, 10, e110383, Public Library of Science ({PLoS}), Oct. 2014, [Peer-reviewed]
  Scientific journal
• The Onset of Heat-Induced Testicular Calcification in Mice
  Masataka Chihara; Teppei Nakamura; Naoki Sakakibara; Saori Otsuka; Osamu Ichii; Yasuhiro Kon
  The American Journal of Pathology, 184, 9, 2480, 2492, Elsevier {BV}, Sep. 2014, [Peer-reviewed]
  Scientific journal
• Podocyte Injury Caused by Indoxyl Sulfate, a Uremic Toxin and Aryl-Hydrocarbon Receptor Ligand
  Osamu Ichii; Saori Otsuka-Kanazawa; Teppei Nakamura; Masaaki Ueno; Yasuhiro Kon; Weiping Chen; Avi Z. Rosenberg; Jeffrey B. Kopp; Maria Pia Rastaldi
  PLoS ONE, 9, 9, e108448, Public Library of Science ({PLoS}), Sep. 2014, [Peer-reviewed]
  Scientific journal
• Genomic Analysis of the Appearance of Ovarian Mast Cells in Neonatal MRL/MpJ Mice
  Teppei Nakamura; Yuko Sakata; Saori Otsuka-Kanazawa; Osamu Ichii; Masataka Chihara; Ken-ichi Nagasaki; Yuka Namiki; Yasuhiro Kon; Andrew Wolfe
  PLoS ONE, 9, 6, e100617, Public Library of Science ({PLoS}), Jun. 2014, [Peer-reviewed], [Lead author]
  Scientific journal
• Pathogenetic role of an autoimmune susceptibility locus derived from MRL/MpJ strain chromosome 1 in chronic pancreas inflammation
  Y Okada; T Nakamura; O Ichii; S Otsuka; Y Kon
  Lupus, 23, 11, 1112, 1123, {SAGE} Publications, May 2014, [Peer-reviewed]
  Scientific journal
• Overexpression of Toll-like receptor 8 correlates with the progression of podocyte injury in murine autoimmune glomerulonephritis
  Junpei Kimura; Osamu Ichii; Kosuke Miyazono; Teppei Nakamura; Taro Horino; Saori Otsuka-Kanazawa; Yasuhiro Kon
  Scientific Reports, 4, 1, Springer Nature, 2014, [Peer-reviewed]
  Scientific journal
• BXSB-type genome causes murine autoimmune glomerulonephritis: pathological correlation between telomeric region of chromosome 1 and Yaa
  J Kimura; O Ichii; T Nakamura; T Horino; S Otsuka; Y Kon
  Genes & Immunity, 15, 3, 182, 189, Springer Nature, Jan. 2014, [Peer-reviewed]
  Scientific journal
• Relationship between Numerous Mast Cells and Early Follicular Development in Neonatal MRL/MpJ Mouse Ovaries
  Teppei Nakamura; Saori Otsuka; Osamu Ichii; Yuko Sakata; Ken-Ichi Nagasaki; Yoshiharu Hashimoto; Yasuhiro Kon; Pierre Bobé
  PLoS ONE, 8, 10, e77246, Public Library of Science ({PLoS}), 04 Oct. 2013, [Peer-reviewed], [Lead author]
  Scientific journal
• Sustained Efficacy of Erythropoietin with a Hydroxyapatite Carrier Administered in Mice
  Ken-ichi NAGASAKI; Toshiyuki IKOMA; Shin-ichi KATSUDA; Toru TONEGAWA; Junzo TANAKA; Teppei NAKAMURA; Hidetaka SATO; Shigeo ITO; Nobuya SASAKI; Takashi AGUI
  Journal of Veterinary Medical Science, 71, 6, 729, 736, Japanese Society of Veterinary Science, 2009, [Peer-reviewed]
  Scientific journal
• Amelioration of Anemia in the ICGN Mouse, a Renal Anemia Model, with a Subcutaneous Bolus Injection of Erythropoietin Adsorbed to Hydroxyapatite Matrix
  Ken-ichi NAGASAKI; Toshiyuki IKOMA; Shin-ichi KATSUDA; Toru TONEGAWA; Junzo TANAKA; Minami OHYAMA; Kosuke HAYASHIDA; Teppei NAKAMURA; Hidetaka SATO; Shigeo ITO; Nobuya SASAKI; Takashi AGUI
  Journal of Veterinary Medical Science, 71, 10, 1365, 1371, Japanese Society of Veterinary Science, 2009, [Peer-reviewed]
  Scientific journal
• Intracellular Localization and Antiviral Property of Canine Mx Proteins
  Teppei Nakamura; Atsushi Asano; Shinya Okano; Jae-Hong Ko; Yasuhiro Kon; Tomomasa Watanabe; Takashi Agui
  Journal of Interferon & Cytokine Research, 25, 3, 169, 173, Mary Ann Liebert Inc, Mar. 2005, [Peer-reviewed], [Lead author]
  Scientific journal

• 医療機器開発における動物試験と動物福祉
  中村鉄平, オベリスク, 28, 2, 3, 9, Jun. 2023, [Invited]
  Japanese, Introduction other
• Study of mucosa-associated lymphoid tissues in farm animals (III)-to identify more effective regions for their vaccination-
  市居修; 中村鉄平; 小千田圭吾; 山下祐輔; 池田哲平, 食肉に関する助成研究調査成果報告書, 38, 2020
• Ovarian mast cells migrate toward the ovary-fimbria connection in neonatal MRL/MpJ mice : a novel role of mast cells unveiled by their localization changes
  中村 鉄平; 市居 修; Yaser Hosny Ali Elewa; 昆 泰寛, Clinical immunology & allergology, 71, 6, 603, 607, Jun. 2019, [Invited]
  東京 : 科学評論社, Japanese
• Study of mucosa-associated lymphoid tissues in farm animals (II)-to identify more effective regions for their vaccination-
  市居修; 中村鉄平; 小千田圭吾; 山下祐輔; 池田哲平, 食肉に関する助成研究調査成果報告書, 37, 2019
• Study of mucosa-associated lymphoid tissues in farm animals-to identify more effective regions for their vaccination-
  市居修; 中村鉄平; 小千田圭吾; 山下祐輔; 池田哲平, 食肉に関する助成研究調査成果報告書, 36, 2018

• Bilingual in Japanese and English Basic Principles of Biological Safety Evaluation Required for Application for Approval to Market Medical Devises 2nd Edition
  Part 4 Implantation Test
  YAKUJI NIPPO, Apr. 2021, [Contributor]
• 安全性試験の教育・研修テキスト 第6版
  病理学的検査
  一般社団法人日本安全性試験受託研究機関協議会, Sep. 2020, [Contributor]

• カルシウム代謝異常 コトンラットで見出した新規表現型の特性評価
  櫻井 菜緒美; 中村 鉄平; 鷲見 嘉奈子; 中西 康; 佐藤 嘉晃
  日本矯正歯科学会大会プログラム・抄録集, Sep. 2025, (公社)日本矯正歯科学会, Japanese
  Sep. 2025 - Sep. 2025
• BALB/cCrSlcマウスにおける低カルシウム血症の遺伝的背景の解明
  中村 鉄平
  日本獣医学会学術集会講演要旨集, Sep. 2025, (公社)日本獣医学会, Japanese
  Sep. 2025 - Sep. 2025
• 多包条虫感染初期の肝組織応答におけるコトンラットと実験用マウスの種差
  中村鉄平; 真鍋真瑠; 佐藤佳祐; 林直樹; 孝口裕一; 中尾亮; 日高正人; 松山紘之; 野中成晃; 森松正美
  日本実験動物学会総会講演要旨集(Web), 2025
  2025 - 2025
• 尿路上皮バリア異常モデルマウスにみられる急性腎障害
  市居修; 岡村匡史; 大谷祐紀; 中村鉄平
  日本獣医学会学術集会講演要旨集, 2024
  2024 - 2024
• ウサギにおける三種混合麻酔薬のDual-route投与
  岩永理沙; 鷲見嘉奈子; 児玉千鶴子; 板宗克; QASIMI Mohammad Ibrahim; 田村純; 中西康; 森松正美; 松村佳代子; 中村鉄平
  日本獣医学会学術集会講演要旨集, 2024
  2024 - 2024
• ウサギにおけるメデトミジン,ブトルファノール,アルファキサロン三種混合麻酔
  板宗克; 岩永理沙; 鷲見嘉奈子; 児玉千鶴子; カセミ モハメド; 田村純; 森松正美; 松村佳代子; 中村鉄平
  日本獣医学会学術集会講演要旨集, 2024
  2024 - 2024
• コラーゲンの質を可視化する:変性コラーゲンと総コラーゲンのin situ多重染色法
  中村鉄平; 市居修; 鷲見嘉奈子; 吉良俊之介; 森松正美; 森松正美
  日本獣医学会学術集会講演要旨集, 2024
  2024 - 2024
• 分化誘導したH9c2細胞株におけるドキソルビシン心筋細胞傷害とNF-kB情報伝達系の解析
  清水真魚; 森松正美; 中村鉄平
  日本獣医学会学術集会講演要旨集, 2024
  2024 - 2024
• バイオデータベースより見出した新規低カルシウム血症モデルマウスの解析
  中村鉄平; 難波貴志; 市居修; 岩永理沙; 笹部一輝; 昆泰寛; 松村佳代子; 森松正美
  日本実験動物学会総会講演要旨集(Web), 2024
  2024 - 2024
• 九州地域の野生獣肉における住肉胞子虫の保有状況
  渡部峻也; 入江隆夫; 和田啓; 中村鉄平; 市居修; 山崎朗子; 吉田彩子
  日本寄生虫学会大会プログラム・抄録集, 2024
  2024 - 2024
• エミューのオリゴアデニレート合成酵素の機能解析
  佐藤 佳祐; 中村 鉄平; 森松 正美; 安居院 高志
  日本獣医学会学術集会講演要旨集, Sep. 2023, (公社)日本獣医学会, Japanese
  Sep. 2023 - Sep. 2023
• 全身に病気を併存する不思議な実験動物「コットンラット」
  中村鉄平
  日本実験動物学会総会講演要旨集(Web), 2023
  2023 - 2023, [Invited]
• 自己免疫疾患モデルマウス頭部にみられる粘膜上皮-免疫連関の変化
  平石真也; 市居修; 中村鉄平; 昆泰寛
  日本獣医学会学術集会講演要旨集, 2023
  2023 - 2023
• 薬物誘導型妊娠糖尿病モデルマウスの作出とその病態について
  高橋なるみ; 市居修; 大谷祐紀; 難波貴志; 平石真也; 中村鉄平; 昆泰寛
  日本獣医学会学術集会講演要旨集, 2023
  2023 - 2023
• コットンラットの胸腺にみられる嚢胞の由来と胸腺機能との関連
  中村鉄平; 市居修; 入江隆夫; 篠原明男; 孝口裕一; 昆泰寛; 森松正美
  日本獣医学会学術集会講演要旨集, 2023
  2023 - 2023
• Epidemiology of Sarcocystis spp. in wild game meat in Kyushu, Japan and evaluation of their pathogenicity
  渡部峻也; 中村鉄平; 市居修; 山崎朗子; 吉田彩子; 入江隆夫
  日本寄生虫学会大会プログラム・抄録集, 2023
  2023 - 2023
• Medical Application of Dairy Waste Cattle-Hypoxic Condition Induces Dense Connective Tissue Formation in Subcutaneously Implanted Molds.
  中村鉄平; 中村鉄平; 市居修; 市居修; 柳瀬圭太; 柳瀬圭太; 池田哲平; 平石真也; 片山由佳; 海田こころ; 新川祐希; 小川美朱; 辻絵里香; 秋吉秀保; 森松正美; 西邑隆徳
  日本バイオマテリアル学会大会予稿集(Web), 2023
  2023 - 2023
• Evaluation of Mechanical Properties of Connective Tissue Prepared in Dairy Waste Cattle for Medical Application.
  柳瀬圭太; 市居修; 中村鉄平; 海田こころ; 片山由佳; 池田哲平; 平石真也; 新川祐希; 小川美朱; 秋吉秀保; 西邑隆徳
  日本バイオマテリアル学会大会予稿集(Web), 2023
  2023 - 2023
• 新規骨軟骨染色法(JFRL染色)の医療機器生物学的安全性試験への応用
  辻 絵里香; 鷲見 嘉奈子; 中村 鉄平; 近藤 大輔; 辻尾 祐志; 細谷 実里奈; 難波 貴志; 脇谷 晶一; 市居 修; 西野 光一郎; 昆 泰寛; 三嶋 隆; 吉安 友二; 勝田 真一
  日本バイオマテリアル学会大会予稿集, Nov. 2022, 日本バイオマテリアル学会, Japanese
  Nov. 2022 - Nov. 2022
• 乳用種廃用牛を利用した移植用結合組織体の作製 スリット形状が与える影響
  片山 由佳; 市居 修; 柳瀬 圭太; 中村 鉄平; 池田 哲平; 難波 貴志; 大谷 祐紀; 昆 泰寛; 西邑 隆徳
  日本獣医学会学術集会講演要旨集, Sep. 2022, (公社)日本獣医学会, Japanese
  Sep. 2022 - Sep. 2022
• 尿管閉塞モデルマウスの尿管移行上皮に誘導される17型コラーゲンの発現動態
  難波 貴志; 市居 修; 中村 鉄平; 大谷 祐紀; 昆 泰寛
  日本獣医学会学術集会講演要旨集, Sep. 2022, (公社)日本獣医学会, Japanese
  Sep. 2022 - Sep. 2022
• マウス急性腎障害期尿の尿路上皮バリアと免疫への作用
  市居 修; 難波 貴志; 大谷 祐紀; Elewa Yaser Hosny Ali; 中村 鉄平; 昆 泰寛
  日本獣医学会学術集会講演要旨集, Sep. 2022, (公社)日本獣医学会, Japanese
  Sep. 2022 - Sep. 2022
• BXSB/MpJ-Yaaマウスの病態からみる全身免疫と頭部粘膜免疫の関連
  平石 真也; 市居 修; 中村 鉄平; Elewa Yaser Hosny Ali; 昆 泰寛
  日本獣医学会学術集会講演要旨集, Sep. 2022, (公社)日本獣医学会, Japanese
  Sep. 2022 - Sep. 2022
• 妊娠期自己免疫疾患モデルマウスの胎盤と妊孕性の関連
  山中 里紗; 市居 修; 中村 鉄平; 大谷 祐紀; 難波 貴志; Hosny Ali Elewa Yaser; 昆 泰寛
  日本獣医学会学術集会講演要旨集, Sep. 2022, (公社)日本獣医学会, Japanese
  Sep. 2022 - Sep. 2022
• コットンラットの系統差比較が解き明かすヒト下咽頭梨状窩瘻の由来
  中村 鉄平; 細谷 実里奈; 市居 修; 渡邉 敬文; Elewa Yaser Hosny Ali; 入江 隆夫; 篠原 明男; 昆 泰寛
  日本獣医学会学術集会講演要旨集, Sep. 2022, (公社)日本獣医学会, Japanese
  Sep. 2022 - Sep. 2022
• 乳用種廃用牛を利用した移植用結合組織体の作製 経時的構成変化の解析
  片山 由佳; 市居 修; 柳瀬 圭太; 中村 鉄平; 池田 哲平; 難波 貴志; 大谷 祐紀; 昆 泰寛; 西邑 隆徳
  日本獣医学会学術集会講演要旨集, Sep. 2021, (公社)日本獣医学会, Japanese
  Sep. 2021 - Sep. 2021
• 自己免疫疾患マウスモデルにおける自己免疫性肺傷害とmediastinal fat-associated lymphoid clusters形成に対するデキサメタゾンの改善作用(Ameliorative effect of dexamethasone on the development of autoimmune lung injury and mediastinal fat-associated lymphoid clusters in autoimmune disease mouse model)
  Elewa Yaser Hosny Ali; Masum Md. Abdul; 市居 修; 中村 鉄平; Sherif Khairy; 昆 泰寛
  日本獣医学会学術集会講演要旨集, Sep. 2021, (公社)日本獣医学会, English
  Sep. 2021 - Sep. 2021
• Interleukin-36受容体を欠損した自己免疫性腎炎モデルマウスの腎表現型解析
  難波 貴志; 市居 修; 岡村 匡史; 中野 堅太; 中村 鉄平; 大谷 祐紀; Md. Abdul Masum; Yaser Hosny Ali Elewa; 昆 泰寛
  第164回日本獣医学会学術集会, Sep. 2021
• 慢性腎炎における尿と腎盤上皮の病態連関
  市居 修; 細谷 実里奈; Masum Md. Abdu; 堀野 太郎; 中村 鉄平; 難波 貴志; 大谷 祐紀; Ali Elewa Yaser Hosn; 昆 泰寛
  第164回日本獣医学会学術集会, Sep. 2021
• 乳用種廃用牛を利用した移植用結合組織体の作製－経時的構成変化の解析－
  片山 由佳; 市居 修; 柳瀬 圭; 中村 鉄平; 池田 哲平; 難波 貴志; 大谷 祐紀; 昆 泰寛; 西邑 隆徳
  第164回日本獣医学会学術集会, Sep. 2021
• マウス全身免疫状態の違いによる異物応答の修飾
  山川 智大; 市居 修; 難波 貴志; 大谷 祐紀; 中村 鉄平; Md. Abdul Masum; Yaser Hosny Ali Elewa; 昆 泰寛
  第164回日本獣医学会学術集会, Sep. 2021
• 骨軟骨組織に対する新規多重染色法(JFRL染色)の有用性
  中村 鉄平; 鷲見 嘉奈子; 辻 絵里香; 都築 奈津子; 近藤 大輔; 辻尾 祐志; 細谷 実里奈; 難波 貴志; 入江 隆夫; 市居 修; 昆 泰寛; 三嶋 隆
  第164回日本獣医学会学術集会, Sep. 2021, Japanese, Oral presentation
• 過脱灰骨標本に適用可能な新規骨染色法の開発
  第1回 日本獣医解剖アカデミア, 06 Mar. 2021, Japanese, Oral presentation
• コットンラットの尾の組織学的特徴および自切機序の解析
  中村 鉄平; 細谷 実里奈; 市居 修; 入江 隆夫; 寸田 祐嗣; Elewa Yaser Hosny Ali; 三嶋 隆; 渡邉 敬文; 植田 弘美; 昆 泰寛
  日本獣医学会学術集会講演要旨集, Oct. 2020, (公社)日本獣医学会, Japanese
  Oct. 2020 - Oct. 2020
• コットンラットの上行結腸に独特な形態がみられる(Unique morphology found in the ascending colon of cotton rats)
  Chuluunbaatar Tsolmon; 市居 修; 中村 鉄平; 入江 隆夫; Yaser Elewa Hosny Ali; 昆 泰寛
  日本獣医学会学術集会講演要旨集, Oct. 2020, (公社)日本獣医学会, English
  Oct. 2020 - Oct. 2020
• 新生仔コットンラット(Sigmodon hispidus)の成長過程における卵巣の変化(Developmental changes of the ovary in the neonatal cotton rat(Sigmodon hispidus))
  Islam Md. Rashedul; 市居 修; 中村 鉄平; 入江 隆夫; Masum Md. Abdul; Yaser Elewa Ali Hosny; 昆 泰寛
  日本獣医学会学術集会講演要旨集, Oct. 2020, (公社)日本獣医学会, English
  Oct. 2020 - Oct. 2020
• 自己免疫疾患モデルマウスの解析からみる腎臓内IL-36群の機能的棲み分け
  難波貴志; 市居修; 中村鉄平; 大谷祐紀; MASUM Md. Abdul; ELEWA Yaser Hosny Ali; 昆泰寛
  日本獣医学会学術集会講演要旨集, 2020
  2020 - 2020
• ネコ尿管の形態と尿管結石症による変化
  市居修; 小山田和央; 水川葉月; 中村鉄平; HOSNY Ali Elewa Yaser; 昆泰寛
  日本獣医学会学術集会講演要旨集, 2020
  2020 - 2020
• マウス卵管の線毛におけるヘッジホッグシグナル伝達経路の発現
  細谷実里奈; 市居修; 中村鉄平; 長谷川靖洋; MASUM Md. Abdul; 渡邉敬文; 植田弘美; 昆泰寛
  日本獣医学会学術集会講演要旨集, 2020
  2020 - 2020
• 自己免疫疾患モデルマウスを用いた糖尿病性腎臓病の病態解明アプローチ
  平松栞; 市居修; 難波貴志; 大谷祐紀; MASUM Md. Abdul; 中村鉄平; ELEWA Yaser Hosny Ali; 昆泰寛
  日本獣医学会学術集会講演要旨集, 2020
  2020 - 2020
• Developmental changes of the ovary in the neonatal cotton rat(Sigmodon hispidus)
  ISLAM Md. Rashedul; 市居修; 中村鉄平; 入江隆夫; MASUM Md. Abdul; ELEWA Yaser Hosny Ali; 昆泰寛
  日本獣医学会学術集会講演要旨集, 2020
  2020 - 2020
• Preventive effect of Tithonia diversifolia-derived orizabin for atherosclerosis and inflammation in Western diet-fed Ldlr KO mice
  井出将博; 鷲見嘉奈子; 中村鉄平; WEN Tan Xian; 吉田泉; 高橋有志; 三嶋隆; 藤田和弘; 五十嵐友二; 松浦栄次
  日本農芸化学会大会講演要旨集(Web), 2020
  2020 - 2020
• SLC:Wistar/STラットで認めた片側性甲状腺形成不全の解析
  中村 鉄平
  第65回東北・北海道連合支部学術集会, 07 Sep. 2019, Japanese, Oral presentation
  [Domestic Conference]
• コットンラットの下咽頭梨状窩瘻を構成する細胞の組織化学的特徴
  中村鉄平; 中村鉄平; 市居修; 入江隆夫; 寸田祐嗣; 細谷実里奈; 長崎健一; YASER HOSNY; Ali Elewa; 三嶋隆; 昆泰寛
  日本獣医学会学術集会講演要旨集, Aug. 2019, (公社)日本獣医学会, Japanese
  Aug. 2019 - Aug. 2019
• マウス生体内異物反応の経時観察-組織局所の炎症と線維化の関連性-
  大江紗央; 市居修; 難波貴志; 大谷祐紀; MD. ABDUL Masum; 中村鉄平; YASER HOSNY Ali Elewa; 西邑隆徳; 中山泰秀; 昆泰寛
  日本獣医学会学術集会講演要旨集, 2019
  2019 - 2019
• 精巣摘出が自己免疫疾患モデルマウスの病態形成へ与える影響
  大谷祐紀; 市居修; YASER HOSNY Ali Elewa; 中村鉄平; 昆泰寛
  日本獣医学会学術集会講演要旨集, 2019
  2019 - 2019
• マウスの卵巣嚢-腹腔連絡路(卵巣嚢孔)
  細谷実里奈; 市居修; 中村鉄平; 難波貴志; YASER HOSNY Ali Elewa; 渡邉敬文; 植田弘美; 昆泰寛
  日本獣医学会学術集会講演要旨集, 2019
  2019 - 2019
• Unique morphological characteristics in the ovary of cotton rat (Sigmodon hispidus)
  ISLAM Md Rashedul; 市居修; 中村鉄平; 入江隆夫; MD ABDUL Masum; YASER HOSNY Ali Elewa; 昆泰寛
  日本獣医学会学術集会講演要旨集, 2019
  2019 - 2019
• 自己免疫疾患モデルマウスで変化する腎臓内Interleukin 1 familyの発現バランス
  難波貴志; 市居修; 中村鉄平; YASER HOSNY Ali Elewa; 昆泰寛
  日本獣医学会学術集会講演要旨集, 2019
  2019 - 2019
• 動物の尿路関連リンパ組織(UTALT)に発現する分子群
  市居修; 中村鉄平; 堀野太郎; 細谷実里奈; YASER HOSNY Ali Elewa; 昆泰寛
  日本獣医学会学術集会講演要旨集, 2019
  2019 - 2019
• 自己免疫疾患モデルマウスにみられる涙液産生組織の形態学的変化
  平石真也; 市居修; 中村鉄平; 難波貴志; YASER HOSNY Ali Eiewa; 昆泰寛
  日本獣医学会学術集会講演要旨集, 2019
  2019 - 2019
• “Mediastinal fat-associated lymphoid cluster and lung asthma development in papain induced lung asthma mice model
  Y. H. A. Elewa; T. Nakamura; O. Ichii; Y. Kon
  The 64th annual meeting of the Japanese the Anatomical Society (Oral Presentation). Aomori, Japan., Sep. 2018, English
  Sep. 2018 - Sep. 2018
• ウシの眼関連リンパ組織について
  小千田圭吾; 市居修; 中村鉄平; 中村鉄平; 池田哲平; 山下祐輔; 長澤裕哉; ALI ELEWA Yaser Hosny; 昆泰寛
  日本獣医学会学術集会講演要旨集, Aug. 2018, (公社)日本獣医学会, Japanese
  Aug. 2018 - Aug. 2018
• 自己免疫疾患モデルマウスで増加する減数分裂特異的精母細胞アポトーシスの原因探索
  大谷祐紀; 市居修; ALI ELEWA; Yaser Hosny; 木村純平; MASUM Md. Abdul; 中村鉄平; 中村鉄平; 昆泰寛
  日本獣医学会学術集会講演要旨集, Aug. 2018, (公社)日本獣医学会, Japanese
  Aug. 2018 - Aug. 2018
• 自己免疫疾患モデルマウスの骨に観察される形態機能的変化
  難波貴志; 市居修; 中村鉄平; 木村純平; 木村純平; 大谷祐紀; ABDUL Masum Md; HOSNY Ali Elewa Yaser; 昆泰寛
  日本獣医学会学術集会講演要旨集, Aug. 2018, (公社)日本獣医学会, Japanese
  Aug. 2018 - Aug. 2018
• 動物の尿路に出現するリンパ組織(Urinary tractassociated lymphoid tissue,UTALT)
  市居修; 中村鉄平; 中村鉄平; 細谷実里奈; 堀野太郎; ALI ELEWA Yaser Hosny; 昆泰寛
  日本獣医学会学術集会講演要旨集, Aug. 2018, (公社)日本獣医学会, Japanese
  Aug. 2018 - Aug. 2018
• Local CD34-positive capillary decreased with the progression of lesion in respective area of kidney in mice.
  Md. A. Masum; O. Ichii; Y. H. A. Elewa; T. Nakamura; Y. Kon
  The 17th International Conference on Nephrology and Urology. London, UK. 13th March 2018., Mar. 2018, English
  Mar. 2018 - Mar. 2018
• ヒトコブラクダ甲状腺の形態学的特徴-鰓後体遺残とC細胞の分布-
  中村鉄平; 市居修; ALI ELEWA Yaser Hosny; 細谷実里奈; GHONIMI Wael A. M.; 辰巳治; 長崎健一; 昆泰寛
  日本獣医学会学術集会講演要旨集, 2018
  2018 - 2018
• 腎疾患の新知見-Casp3欠損マウスにみられる腎病変-
  鈴木崇史; 市居修; 中村鉄平; ALI ELEWA Yaser Hosny; 昆泰寛
  日本獣医学会学術集会講演要旨集, 2018
  2018 - 2018
• MRL/MpJ-Fas^lpr/lprマウスの全身自己免疫異常が線毛運動機能に与える影響
  細谷実里奈; 市居修; ALI ELEWA Yaser Hosny; 中村鉄平; 昆泰寛
  日本獣医学会学術集会講演要旨集, 2018
  2018 - 2018
• Study of mucosa-associated lymphoid tissues in farm animals-to identify more effective regions for their vaccination-
  市居修; 中村鉄平; 小千田圭吾; 山下祐輔; 池田哲平
  食肉に関する助成研究調査成果報告書, 2018
  2018 - 2018
• FAT ACCUMULATION CORRELATES WITH DIABETES MELLITUS IN MALE COTTON RATS (SIGMODON HISPIDUS).
  T. Nakamura; O. Ichii; T. Irie; H. Kouguchi; Y. Sunden; K.-I. Nagasaki; Y. H. A. Elewa; Y. Kon
  The 6th Congress of Asian Association of Veterinary Anatomists, Malaysia, Oct. 2017
  Oct. 2017 - Oct. 2017
• IL-1F6/IL-36α SIGNALING REGULATES RENAL INFLAMMATION.
  O. Ichii; J. Kimura; T. Okamura; T. Horino; T. Nakamura; H. Sasaki; H. A. Elewa; Y. Kon
  The 6th Congress of Asian Association of Veterinary Anatomists, Malaysia, Oct. 2017, English
  Oct. 2017 - Oct. 2017
• ABNOLMALITY OF OVULATION AND OOCYTE-PICK-UP IN MRL/MpJ-Faslpr/lpr MICE.
  Hosotani; O. Ichii; Y. H. A. Elewa; T. Nakamura; S. Otsuka-Kanazawa; Y. Kon
  ABNOLMALITY OF OVULATION AND OOCYTE-PICK-UP IN MRL/MpJ-Faslpr/lpr MICE. The 6th Congress of Asian Association of Veterinary Anatomists, Malaysia, Oct. 2017, English
  Oct. 2017 - Oct. 2017
• BXSB/MpJ-Yaa MICE SHOW THE INCREASE OF APOPTOTIC SPERMATOCYTES IN STAGE Ⅻ SEMINIFEROUS TUBULES.
  Y. Otani; O. Ichii; Y. H. A. Elewa; T. Nakamura; Y. Kon
  The 6th Congress of Asian Association of Veterinary Anatomists (Asian AVA). Kuching, Sarawak, Malaysia. October 12-13, 2017., Oct. 2017, English
  Oct. 2017 - Oct. 2017
• “Dual effects of bleomycin on the intra-thoracic immune hemostasis and lung injury in autoimmune disease model mice”.
  Y. H. A. Elewa; T. Nakamura; O. Ichii; Y. Kon
  The 63th annual meeting of the Japanese the Anatomical Society., Sep. 2017, English
  Sep. 2017 - Sep. 2017
• Histopathological features observed in the testis of autoimmune-prone BXSB/MpJ-Yaa mice.
  Y. Otani; O. Ichii; Y. H. A. Elewa; T. Nakamura; Y. Kon
  The 5th Sapporo Summer Seminar for One Health., Sep. 2017, English
  Sep. 2017 - Sep. 2017
• “Loss of endothelial fenestration correlates with podocyte injury in the mouse model of membranoproliferative glomerulonephritis.”
  Md. A. Masum; O. Ichii; Y. H. A. Elewa; T. Nakamura; Y. Kon
  The 5th Sapporo Summer Seminar for One Health (SASSOH). September 20-21, 2017. Sapporo, Japan., Sep. 2017, English
  Sep. 2017 - Sep. 2017
• “Mechanism and abnormality of ovulation and picking up of mammalian oocytes-Immune factors affecting the molecular morphology of the oviduct.”
  M. Hosotani; O. Ichii; Y. H. A. Elewa; T. Nakamura; Y. Kon
  The 5th Sapporo Summer Seminar for One Health (SASSOH). September 20-21, 2017. Sapporo, Japan., Sep. 2017, English
  Sep. 2017 - Sep. 2017
• Caspase3欠損マウスからみる細胞死―自己免疫連関異常の新たなエビデンス
  市居修; 堀野太郎; 大田寛; 鈴木崇史; 中村鉄平; 中村鉄平; ELEWA Yaser; Hosny Ali; 昆泰寛
  日本獣医学会学術集会講演要旨集, 30 Aug. 2017, (公社)日本獣医学会, Japanese
  30 Aug. 2017 - 30 Aug. 2017
• BXSB/MpJ‐Yaaマウスにみられる精母細胞のアポトーシス―自己免疫異常との関連性―
  大谷祐紀; 市居修; ELEWA Yaser; Hosny Ali; 木村純平; MASUM Md. Abdul; 中村鉄平; 中村鉄平; 昆泰寛
  日本獣医学会学術集会講演要旨集, 30 Aug. 2017, (公社)日本獣医学会, Japanese
  30 Aug. 2017 - 30 Aug. 2017
• MRL/MpJマウスの排卵―黄体形成過程にみられる特異な表現型
  細谷実里奈; 市居修; ELEWA Yaser; Hosny Ali; 中村鉄平; 中村鉄平; 昆泰寛
  日本獣医学会学術集会講演要旨集, 30 Aug. 2017, (公社)日本獣医学会, Japanese
  30 Aug. 2017 - 30 Aug. 2017
• 雌性コットンラットの胸腺にみられる加齢性変化
  中村鉄平; 中村鉄平; 市居修; 入江隆夫; 篠原明雄; 孝口裕一; 越本知大; 長崎健一; 寸田祐嗣; ELEWA Yaser Hosny; 辰巳治; 昆泰寛
  日本獣医学会学術集会講演要旨集, Aug. 2017, (公社)日本獣医学会, Japanese
  Aug. 2017 - Aug. 2017
• Sarcocystis属原虫の終宿主候補としてのキタキツネにおける調査
  入江隆夫; 浦口宏二; 中村鉄平; 中村鉄平; 市居修; 高井伸二; 八木欣平
  日本獣医学会学術集会講演要旨集, Aug. 2017, (公社)日本獣医学会, Japanese
  Aug. 2017 - Aug. 2017
• マウス糸球体の自己免疫関連傷害における内皮細胞と有足細胞との病理学的相関性(Pathological correlations between endothelial cells and podocytes in autoimmune-related injury of the mouse glomerulus)
  Masum Md. Abdul; 市居 修; Elewa Yaser Hosny Ali; 中村 鉄平; 昆 泰寛
  日本獣医学会学術集会講演要旨集, Aug. 2017, (公社)日本獣医学会, English
  Aug. 2017 - Aug. 2017
• Elucidation of mammalian reproductive - autoimmune coupling mechanism and analysis of pathological conditions caused by its failure.
  Y. Otani; O. Ichii; Y. H. A. Elewa; T. Nakamura
  Y. Kon. The 35th Scientific annual joint meeting of Hokkaido Veterinary Anatomy, Aug. 2017, Japanese
  Aug. 2017 - Aug. 2017
• BXSB/MpJ-Yaaマウスにみられる精母細胞のアポトーシス-自己免疫異常との関連性-
  大谷祐紀; 市居修; ELEWA Yaser Hosny Ali; 木村純平; MASUM Md. Abdul; 中村鉄平; 昆泰寛
  日本獣医学会学術集会講演要旨集, 2017
  2017 - 2017
• MRL/MpJマウスの排卵-黄体形成過程にみられる特異な表現型
  細谷実里奈; 市居修; ELEWA Yaser Hosny Ali; 中村鉄平; 昆泰寛
  日本獣医学会学術集会講演要旨集, 2017
  2017 - 2017
• Caspase3欠損マウスからみる細胞死-自己免疫連関異常の新たなエビデンス
  市居修; 堀野太郎; 大田寛; 鈴木崇史; 中村鉄平; ELEWA Yaser Hosny Ali; 昆泰寛
  日本獣医学会学術集会講演要旨集, 2017
  2017 - 2017
• 医療機器の埋植試験~外挿性,使用動物の適切性~
  勝田真一; 佐藤弘昌; 中村鉄平; 服部秀樹; 長崎健一
  日本実験動物学会総会講演要旨集, 2017
  2017 - 2017
• 自己免疫疾患モデルMRL/MpJ-Faslprマウスにみられる卵子のキャッチアップ障害
  細谷 実里奈; 中村 鉄平; Hosny Ali Elewa Yaser; 市居 修; 昆 泰寛
  日本獣医学会学術集会講演要旨集, Aug. 2016, (公社)日本獣医学会, Japanese
  Aug. 2016 - Aug. 2016
• マウス遠位尿細管の嚢胞形成に関与する新規原因遺伝子座の役割
  市居修; 中村鉄平; 中村鉄平; 矢吹映; 堀野太郎; 昆泰寛
  日本獣医学会学術集会講演要旨集, Aug. 2016, (公社)日本獣医学会, Japanese
  Aug. 2016 - Aug. 2016
• コットンラットにおけるインスリン抵抗性と脂肪蓄積との関連
  中村鉄平; 中村鉄平; 市居修; 入江隆夫; 寸田祐嗣; 孝口裕一; 長崎健一; 吉安友二; 昆泰寛
  日本獣医学会学術集会講演要旨集, Aug. 2016, (公社)日本獣医学会, Japanese
  Aug. 2016 - Aug. 2016
• エゾシカに寄生するSarcocystis属原虫の終宿主動物探索
  入江隆夫; 池田徹也; 中村鉄平; 中村鉄平; 市居修; 山田智子; 伊東拓也; 山崎朗子; 高井伸二; 八木欣平
  日本獣医学会学術集会講演要旨集, Aug. 2016, (公社)日本獣医学会, Japanese
  Aug. 2016 - Aug. 2016
• マウス腎臓病モデルにおける疾患進行に伴うCD34陽性毛細血管の減少(CD34-positive capillary decreased with the progression of kidney disease in mouse models)
  Masum Md.Abdul; Yaser Hosny Ali Elewa; 中村 鉄平; 市居 修; 昆 泰寛
  日本獣医学会学術集会講演要旨集, Aug. 2016, (公社)日本獣医学会, English
  Aug. 2016 - Aug. 2016
• マウスにおける縦隔脂肪関連リンパクラスターとブレオマイシン誘発性肺炎との病理組織学的関連(Histopathological correlations between the mediastinal fat associated lymphoid clusters and bleomycin-induced pneumonitis in mice)
  Yaser Hosny Ali Elewa; Masum Md.Abdul; 中村 鉄平; 市居 修; 昆 泰寛
  日本獣医学会学術集会講演要旨集, Aug. 2016, (公社)日本獣医学会, English
  Aug. 2016 - Aug. 2016
• 自己免疫疾患モデルMRL/MpJ-Fas^lprマウスにみられる卵子のキャッチアップ障害
  細谷実里奈; 中村鉄平; HOSNY Ali Elewa Yaser; 市居修; 昆泰寛
  日本獣医学会学術集会講演要旨集, 2016
  2016 - 2016
• 芳香族炭化水素受容体シグナルの活性化は胃粘膜異常を増悪する-遺伝子改変モデルマウスを用いたin vivo解析-
  團塚愛; HANBERG Annika; 中村鉄平; 市居修; 昆泰寛
  日本獣医学会学術集会講演要旨集, 2016
  2016 - 2016
• コットンラットの咽頭喉頭部,甲状腺及びその周囲組織にみられる形態異常
  中村鉄平; 中村鉄平; 入江隆夫; 市居修; 篠原明夫; 浦口宏二; 越本知大; 長崎健一; 昆泰寛
  日本獣医学会学術集会講演要旨集, Aug. 2015, (公社)日本獣医学会, Japanese
  Aug. 2015 - Aug. 2015
• 遠位尿細管傷害を知らせるマーカー分子“IL-1F6/IL-36a”の有用性
  市居修; 中村鉄平; 中村鉄平; 堀野太郎; 木村純平; 岡村匡史; 昆泰寛
  日本獣医学会学術集会講演要旨集, 2015
  2015 - 2015
• Analysis of mast cells in the neonatal ovary of MRL/MpJ mice -unique immune cells participating in early follicular development-
  Teppei Nakamura
  JAPANESE JOURNAL OF VETERINARY RESEARCH, Nov. 2014, English, Others
  Nov. 2014 - Nov. 2014
• 新生子MRL/MpJマウスにおける卵巣内肥満細胞の由来―卵巣‐卵巣采結合部から出現する可能性―
  中村鉄平; 千原正尚; 市居修; 大塚沙織; 長崎健一; 昆泰寛
  日本獣医学会学術集会講演要旨集, Aug. 2014, (公社)日本獣医学会, Japanese
  Aug. 2014 - Aug. 2014
• 腎障害時にみられるMRL/MpJマウスの特別な修復過程について
  塩水流大地; 市居修; 中村鉄平; 大塚沙織; 昆泰寛
  日本獣医学会学術集会講演要旨集, Aug. 2014, (公社)日本獣医学会, Japanese
  Aug. 2014 - Aug. 2014
• 自己免疫疾患モデルMRL/MpJ‐lprマウスの卵巣は機能形態異常を示す
  大谷祐紀; 市居修; 大塚沙織; 中村鉄平; 千原正尚; 昆泰寛
  日本獣医学会学術集会講演要旨集, Aug. 2014, (公社)日本獣医学会, Japanese
  Aug. 2014 - Aug. 2014
• Toll‐like receptor 8は自己免疫性糸球体腎炎の足細胞傷害に関与する
  木村純平; 市居修; 大田寛; 中村鉄平; 堀野太郎; 大塚沙織; 昆泰寛
  日本獣医学会学術集会講演要旨集, Aug. 2014, (公社)日本獣医学会, Japanese
  Aug. 2014 - Aug. 2014
• Greb1―DBA/2Crマウスに出現する遠位尿細管由来嚢胞の原因遺伝子候補―
  市居修; 大塚沙織; 矢吹映; 堀野太郎; 中村鉄平; 昆泰寛
  日本獣医学会学術集会講演要旨集, Aug. 2014, (公社)日本獣医学会, Japanese
  Aug. 2014 - Aug. 2014
• Greb1-DBA/2Crマウスに出現する遠位尿細管由来嚢胞の原因遺伝子候補-
  市居修; 大塚沙織; 矢吹映; 堀野太郎; 中村鉄平; 中村鉄平; 昆泰寛
  日本獣医学会学術集会講演要旨集, 2014
  2014 - 2014
• 新生子MRL/MpJマウスにおける卵巣内肥満細胞の由来-卵巣-卵巣采結合部から出現する可能性-
  中村鉄平; 千原正尚; 市居修; 大塚沙織; 長崎健一; 昆泰寛
  日本獣医学会学術集会講演要旨集, 2014
  2014 - 2014
• MRL/MpJマウス新生子卵巣に出現する肥満細胞の解析
  中村 鉄平
  日本解剖学会 第62回東北・北海道連合支部学術集会, 15 Sep. 2013, Japanese, Oral presentation
  [Domestic Conference]
• MRLマウス肥満細胞は新生子期の卵形成に関与する
  中村鉄平; 市居修; 大塚沙織; 坂田侑子; 長崎健一; 橋本善春; 昆泰寛
  日本獣医学会学術集会講演要旨集, Mar. 2013, (公社)日本獣医学会, Japanese
  Mar. 2013 - Mar. 2013
• 糸球体病変を制御するmiRNAの探索―動物種共通のバイオマーカー開発を目指して―
  市居修; 大塚沙織; 中村鉄平; 野元由佳; 橋本善春; 堀野太郎; 昆泰寛
  日本獣医学会学術集会講演要旨集, Mar. 2013, (公社)日本獣医学会, Japanese
  Mar. 2013 - Mar. 2013
• MRL/MpJマウスの卵巣内肥満細胞出現に関与する遺伝的因子の解析
  中村鉄平; 坂田侑子; 大塚沙織; 市居修; 並木由佳; 長崎健一; 橋本善春; 昆泰寛
  日本獣医学会学術集会講演要旨集, Mar. 2012, (公社)日本獣医学会, Japanese
  Mar. 2012 - Mar. 2012
• マウス新生子卵巣に出現する肥満細胞の系統差解析
  中村鉄平; 市居修; 大塚沙織; 並木由佳; 坂田侑子; 長崎健一; 服部秀樹; 橋本善春; 昆泰寛
  日本獣医学会学術集会講演要旨集, Aug. 2011, (公社)日本獣医学会, Japanese
  Aug. 2011 - Aug. 2011
• MRLマウス新生子卵巣における肥満細胞の出現
  中村鉄平; 市居修; 大塚沙織; 並木由佳; 長崎健一; 服部秀樹; 橋本善春; 昆泰寛
  日本獣医学会学術集会講演要旨集, Mar. 2011, (公社)日本獣医学会, Japanese
  Mar. 2011 - Mar. 2011
• エリスロポエチン含有ハイドロキシアパタイトを用いた腎性貧血の持続的改善
  長崎健一; 生駒俊之; 勝田真一; 利根川亨; 田中順三; 中村鉄平; 佐藤秀隆; 伊藤茂男; 佐々木宣哉; 安居院高志
  日本獣医学会学術集会講演要旨集, 2009
  2009 - 2009
• 亜鉛含有ハイドロキシアパタイト微粒子を用いたエリスロポエチンの徐放効果に関する研究
  長崎健一; 生駒俊之; 勝田真一; 利根川亨; 田中順三; 中村鉄平; 佐藤秀隆; 佐々木宣哉; 安居院高志
  日本獣医学会学術集会講演要旨集, 2008
  2008 - 2008

• アドバンスト演習, 2024年, 学士課程, 獣医学部
• 研究倫理演習, 2024年, 博士後期課程, 獣医学院
• 研究倫理演習, 2024年, 博士後期課程, 国際感染症学院
• 実験動物学特論, 2024年, 博士後期課程, 獣医学院
• アドバンスト演習, 2024年, 学士課程, 獣医学部
• アドバンスト演習, 2024年, 学士課程, 獣医学部
• アドバンスト演習, 2024年, 学士課程, 獣医学部
• アドバンスト演習, 2024年, 学士課程, 獣医学部
• 基礎動物栄養学, 2024年, 学士課程, 獣医学部
• 実験動物学実習, 2024年, 学士課程, 獣医学部

• Jul. 2023 - Present
  日本バイオマテリアル学会
• Jul. 2022 - Present
  Japanese Association for Laboratory Animal Science
• Feb. 2022 - Present
  Japanese Association for Laboratory Animal Medicine
• Feb. 2011 - Present
  THE JAPANESE SOCIETY OF VETERINARY SCIENCE
• Present
  日本獣医腎泌尿器学会
• Mar. 2025
  日本解剖学会

• リン酸化プルランバイオアドヒーシブを用いた革新的唇顎口蓋裂治療法開発に向けた探索的医師主導治験
  日本医療研究開発機構研究費 小児用医療機器の実用化を目指す臨床研究・治験等
  Apr. 2026 - Mar. 2029
  中西康; 吉田靖弘; 林宏至; 中村鉄平; 玉田一敬; 森川和彦; 坂本好昭
  日本医療研究開発機構, 北海道大学, Coinvestigator
• Age-related development of urinary tract-associated lymphoid tissue as a driver of chronic kidney inflammation
  Grants-in-Aid for Scientific Research
  Apr. 2025 - Mar. 2029
  市居 修; 岡村 匡史; 福島 建次郎; 大谷 祐紀; 山崎 淳平; 中村 鉄平; 堀野 太郎; 難波 貴志
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (A), Hokkaido University, 25H00957
• 骨再生に最適化した材料・薬剤を患部に留める硬組織接着性ゲル状万能基材の開発
  科学研究費助成事業
  01 Apr. 2025 - 31 Mar. 2028
  中西 康; 中村 鉄平
  日本学術振興会, 基盤研究(C), 北海道大学, 25K13062
• リン酸化プルランを用いた多様な組織反応を誘導する細胞操作基盤の確立
  調査研究助成
  Jan. 2026 - Mar. 2027
  中村鉄平; 吉田靖弘; 中西康
  鈴木謙三記念医科学応用研究財団, Principal investigator
• 骨再生制御材料を用いた頭蓋骨縫合早期癒合症の低侵襲治療法確立
  難治性疾患等実用化研究事業 難治性疾患実用化研究事業
  Apr. 2024 - Mar. 2027
  玉田一敬; 森川和彦; 林宏至; 中西康; 中村鉄平; 吉田靖弘
  日本医療研究開発機構, Coinvestigator
• リン酸化プルランバイオアドヒーシブを用いた革新的唇顎口蓋裂治療法の開発
  医療機器開発推進研究事業 小児用医療機器の実用化を目指す医師主導治験・臨床研究
  Apr. 2022 - Mar. 2027
  吉田靖弘; 玉田一敬; 坂本好昭; 森川和彦; 吉原久美子; 伊東孝; 中村真理子; 赤坂司; 中西康; 中村鉄平
  日本医療研究開発機構, Coinvestigator
• 吸収期間を制御する機能性ゲル状スキャフォールドの開発
  札幌バイオシーズ事業化支援事業
  Aug. 2025 - Mar. 2026
  中村 鉄平
  公益財団法人北海道科学技術総合振興センター, 札幌バイオシーズ事業化支援補助金【シーズ育成枠】, 北海道大学, Principal investigator, SB-se-12
• 骨芽細胞分化・骨形成能を有する接着性スキャフォールドの開発
  Ⅲ研究助成金
  Jan. 2025 - Mar. 2026
  中村 鉄平
  公益財団法人 テルモ生命科学振興財団, 北海道大学, Principal investigator, 24-III3023
• Renal pelvis-kidney disease axis based on the induction of lymphoid tissue development by urine
  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)
  Apr. 2021 - Mar. 2025
  市居 修; 岡村 匡史; 昆 泰寛; 西邑 隆徳; 矢吹 映; 山崎 淳平; 中村 鉄平; 細谷 実里奈; 堀野 太郎
  ヒトと伴侶動物では、個体の高齢化に伴い慢性腎臓病(CKD)症例が増えている。CKDは糸球体や尿細管間質の慢性炎症を主体とし、難治性である。近年、腎臓内に形成された誘導性 リンパ組織による慢性炎症の増悪と遷延が問題視されている。我々は腎盤(腎臓から尿を受ける嚢状構造、腎盂)に尿路関連リンパ組織(UTALT/UTALS)を発見し、その発達がCKD進行と強く相関することを見出した。本研究では、疾患モデル動物や伴侶動物・ヒト症例の精査を基軸に、CKDにおけるUTALS発達の意義、特に腎臓の慢性炎症との病態連関を解明する。さらに、UTALTが発達する理由として“CKD時の尿が導く腎盤上皮バリアの脆弱化とそれに続く尿の腎盤侵入”を証明し、尿の新たな存在意義“リンパ組織の発達誘導”を提唱する。
  これまでヒトとマウスのUTALSは、移行上皮直下でT細胞、B細胞やマクロファージ等の免疫細胞で構成され、膠原線維や細網線維を含むことを明らかにした。また、腎盤UTALSでは、CCL・CXCLケモカインおよびその受容体遺伝子が発現しており、これらケモカインは主に腎盤間質に発現していた。腎炎モデルマウス(MRL/lpr)のUTALSは顕著に発達し、CCL・CXCLケモカインの発現は腎病理スコア(糸球体傷害、尿細管間質傷害、誘導性リンパ組織形成)と有意に正の相関にあった。また、MRL/lprの腎盤上皮は形態や細胞間接着分子(Occludin、ZO-1)の発現を変化させ、腎盤上皮バリア異常が示唆された。さらに色素の尿路逆行性投与実験において、MRL/lprでは色素が腎盤腔から腎盤組織に漏れ出た。今後、尿とUTALSの関係をさらに詳細に解析する。
  腎盤を巻き込む腎臓病の重篤化は深刻であり、死亡率も高い。本研究では、UTALSを中心とした腎盤－腎臓病態軸の解明から、難治性疾患CKDの治療戦略に新たな道を切り拓く。
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (A), Hokkaido University, Coinvestigator, 21H04751
• ウシのリンパ陰部輪の発見 ―粘膜ワクチン投与部位としての有効性―
  科学研究費助成事業 基盤研究(B)
  Apr. 2019 - Mar. 2024
  昆 泰寛; エレワ ヤセル; 市居 修; 中村 鉄平
  我々は、ウシを主として、様々な動物種における尿生殖器の粘膜関連リンパ組織を探索している。特に、生殖器は外界と直接交通しており、抗原に暴露されやすい部位である。一方、動物におけるその存在には不明な点が多い。特に産業動物獣医療では、感染症対策のために局所粘膜免疫の誘導が重要であり、その局在解析は粘膜ワクチン等への臨床応用に繋がると考えている。
  まず今年度は、実験動物種（マウス、コットンラット）の尿生殖器を精査し、その有無を組織学的に調べた。これらの動物種の泌尿器には、リンパ球や細網線維・膠原線維で構成されるリンパ組織様構造が観察される一方、生殖器にその存在を見出せなかった。次いで、ウシに加えて、ヤギ、ミニブタおよびイヌの生殖器を形態学的に解析し、粘膜リンパ組織の有無を検証した。ホールマウントヘマトキシリン標本の観察において、いずれの動物においても腟前庭部位に小円形ならびにクレーター状の構造が観察された。これらは特に陰核窩周囲に多い傾向にあった。この構造を組織学的観察したところ、腟前庭の粘膜上皮細胞が一部欠損し、その直下にリンパ球の散在性あるいは濾胞性集簇が認められた。
  我々はこのような構造を「生殖器関連リンパ組織」と定義しており、これらは特に外界に接する陰部で発達し、ワルダイエル咽頭輪のように「リンパ陰部輪」を形成して免疫学的関門を担っていると考えている。本年度は形態学的解析を中心に進めたが、来年度は機能的な推察など、更なる解析を進める。
  日本学術振興会, 基盤研究(B), 北海道大学, Coinvestigator, 19H03113
• 組織接着性を有した生体吸収性多糖と成長因子による難治性歯周病治療法の開発
  令和４年度調査研究助成
  Jan. 2023 - Jan. 2024
  中西 康; 中村鉄平
  公益財団法人鈴木謙三記念医科学応用研究財団, 北海道大学, Coinvestigator
• Novel immune-related nephrology and urology evolving from the discovery of Urinary Tract-Associated Lymphoid Structure
  Grants-in-Aid for Scientific Research
  Jun. 2019 - Mar. 2022
  Ichii Osamu
  Locally developed lymphoid tissue plays an important role in infection defense. In recent years, the role of mucosa-associated lymphoid tissue has been attracting particular attention, and it has been reported in the eye, respiratory tract, and intestinal tract. In this study, we have examined the kidney and urinary tracts of mice and found a new immune-related tissue called "Urinary Tract-Associated Lymphoid Structure (UTALS)”. Since there is little information on UTALS, we investigated its function and pathological significance.
  Japan Society for the Promotion of Science, Grant-in-Aid for Challenging Research (Exploratory), Hokkaido University, Coinvestigator, 19K22352
• Make Eve from Adam - challenge of animal creation by using only male genome -
  Grants-in-Aid for Scientific Research Challenging Research (Exploratory)
  Jun. 2019 - Mar. 2022
  Kon Yasuhiro
  This study tries to elucidate the significance of oocytes in the testis, verify the mechanism of transformation of spermatogenic cells into oocytes, and finally generate individuals using only the male genome. Firstly, we examined methods to isolate oocytes appearing in the testes of MRL/MpJ mice and explore a method to collect the testicular oocytes efficiently and with preserved morphology. Testicular oocytes were most efficiently isolated by the manual, and their morphology was preserved. On the other hand, it was necessary to consider the functional differences between testicular oocytes and ovarian oocytes and further study of culture methods. We hope that the fertilization and embryogenesis potential of testicular oocytes will be clarified and applied their knowledge to animal reproduction, especially in livestock breeding, reproductive engineering, and the protection of rare animal populations.
  Japan Society for the Promotion of Science, Challenging Research (Exploratory), Hokkaido University, Coinvestigator, 19K22409
• Cotton rats: novel animal models for comorbidities
  Grants-in-Aid for Scientific Research
  Apr. 2018 - Mar. 2021
  Nakamura Teppei
  This study revealed that the experimental rodents with sensitivity to human pathogens "cotton rats" coexisted with multiple phenotypes, and investigated the phenotypes. As a result, cotton rats coexisted with multiple phenotypes such as metabolic syndrome and chronic kidney disease, which are increasing in morbidity in humans, and can mimic human comorbidities. Furthermore, these phenotypes showed sex-differences, and were associated with autoimmune diseases. As mentioned above, this study showed that cotton rats might be a model of human comorbidity and concluded that they contribute to the elucidation of the interaction between individual diseases.
  Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, Principal investigator, 18K07037

• コットンラット〜全身に病気を併存する不思議な実験動物〜
  Sep. 2022
  Myself
  日本実験動物医学会
  コラム
  [Internet]