Kato-Suzuki Mira(Faculty of Veterinary Medicine　Veterinary Medicine　Basic Veterinary Sciences)

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Kato-Suzuki Mira

Faculty of Veterinary Medicine　Veterinary Medicine　Basic Veterinary Sciences Assistant Professor

Researcher basic information

■ Degree

学士（獣医学）, 麻布大学, Mar. 2021

■ URL
researchmap URL

https://researchmap.jp/mira_kato-suzuki?lang=en

ホームページURL

https://jglobal.jst.go.jp/detail?JGLOBAL_ID=202401016896393650

■ Various IDs
Researcher number

41000318

J-Global ID

202401016896393650

■ Educational Organization

Doctoral (PhD) degree program, Graduate School of Veterinary Medicine

Career

■ Career
Educational Background

Apr. 2021 - Mar. 2024, Hokkaido University, 大学院獣医学院

Apr. 2015 - Mar. 2021, Azabu University, School of Veterinary Medicine, Department of Veterinary Medicine

Research activity information

■ Awards

Jul. 2024, 日本生化学会北海道支部, 優秀講演賞

Feb. 2023, 日本酸化ストレス学会若手の会, 最優秀演題賞

Oct. 2022, 第165回日本獣医学術集会, 優秀発表賞

Aug. 2020, 麻布大学, 増井光子賞

Dec. 2019, 日本学生支援機構, 優秀学生顕彰学術分野優秀賞

Apr. 2019, The 9th Biennial Meeting of Society for Free Radical Research-Asia, Young Investigator Awards of SFRR Asia 2019

Aug. 2018, 日本酸化ストレス学会フリーラジカルスクール, 優秀演題賞

■ Papers

Maternal vitamin A deficiency suppresses browning of white adipose tissue in offspring.
Mira Kato-Suzuki; Anju Tsukada; Emi Futagawa; Takito Itoi; Osamu Inanami; Kazuhiro Kimura; Yuko Okamatsu-Ogura
The FEBS journal, 31 Mar. 2026, [Peer-reviewed], [Lead author], [International Magazine]
English, Scientific journal, Beige adipocytes transiently emerge in white adipose tissue (WAT) during early postnatal development in mice (postnatal browning) independent of sympathetic innervation. However, the underlying mechanism remains unclear. Retinoic acid (RA), an active metabolite of vitamin A, has been reported to promote angiogenesis and browning. In this study, we aimed to elucidate the physiological role of vitamin A in postnatal browning. Maternal vitamin A deficiency, induced by feeding dams a vitamin A-deficient diet during pregnancy and lactation, suppressed browning in the offspring. In contrast, feeding dams a vitamin A-deficient diet only during pregnancy had no effect on the browning of the offspring. Additionally, browning was significantly suppressed by administration of a retinoic acid receptor (RAR) antagonist to pups during either the early (postnatal days 4-12) or late (postnatal days 12-20) lactation period. Maternal vitamin A deficiency and RAR inhibition during early lactation suppressed angiogenesis, which has been suggested to be required for the browning process in adults, whereas RAR inhibition during late lactation did not affect angiogenesis. These findings demonstrate that vitamin A plays a pivotal role in the induction of postnatal browning. Furthermore, we found that vitamin A affects the two-phase process of postnatal browning: promoting angiogenesis and progenitor proliferation in the early lactation period, followed by its action in the late lactation period on the differentiation of beige adipocytes, independently of angiogenesis.

Corrigendum to "Eva1 deficiency prevents obesity-induced metabolic disorders by reducing visceral adipose dysfunction" [Metabolism 168 (2025) 156235].
You Lee Son; Jiahui Hou; Mira Kato-Suzuki; Yuko Okamatsu-Ogura; Megumi Watase; Hiroshi Kiyonari; Toru Kondo
Metabolism: clinical and experimental, 170, 156299, 156299, Sep. 2025, [International Magazine]
English

Eva1 deficiency prevents obesity-induced metabolic disorders by reducing visceral adipose dysfunction
You Lee Son; Jiahui Hou; Mira Kato-Suzuki; Yuko Okamatsu-Ogura; Megumi Watase; Hiroshi Kiyonari; Toru Kondo
Metabolism, 156235, 156235, Elsevier BV, Mar. 2025, [Peer-reviewed]
Scientific journal

Time-dependent changes in retinoids content in liver and adipose tissue after feeding of a vitamin A-deficient diet to mice
Mira KATO-SUZUKI; Yuko OKAMATSU-OGURA; Osamu INANAMI; Kazuhiro KIMURA
Experimental Animals, Japanese Association for Laboratory Animal Science, 2024, [Peer-reviewed], [Lead author]
English, Scientific journal

母親のビタミンA欠乏食摂取は子のベージュ脂肪細胞の出現を抑制する
加藤美羅; 岡松優子; 塚田杏樹; 二川瑛実; 稲波修; 木村和弘
日本獣医学会学術集会講演要旨集, 166回, 185, 185, (公社)日本獣医学会, Sep. 2023
Japanese

White adipose tissue undergoes browning during preweaning period in association with microbiota formation in mice
Anju Tsukada; Yuko Okamatsu-Ogura; Emi Futagawa; Yuki Habu; Natsumi Takahashi; Mira Kato-Suzuki; Yuko Kato; Satoshi Ishizuka; Kei Sonoyama; Kazuhiro Kimura
iScience, 26, 7, 107239, 107239, Elsevier BV, Jul. 2023, [Peer-reviewed]
English, Scientific journal

Ganglioside GM3 deficiency enhances mast cell sensitivity
Mariko Komuro; Hinano Mizugaki; Masaki Nagane; Misako Morimoto; Tomoki Fukuyama; Kikumi Ogihara; Yuko Naya; Emi Yokomori; Kimika Kaneshima; Yasushi Kawakami; Junichi Kamiie; Yuki Shibata; Mira Suzuki; Takuto Shimizu; Nagako Kawashima; Mariko Okamoto; Teruo Ikeda; Tadashi Yamashita
The FEBS Journal, 290, 17, 4268, 4280, Wiley, 05 May 2023, [Peer-reviewed]
English, Scientific journal, Mast cells are a significant source of cytokines and chemokines that play a role in pathological processes. Gangliosides, which are complex lipids with a sugar chain, are present in all eukaryotic cell membranes and comprise lipid rafts. Ganglioside GM3, the first ganglioside in the synthetic pathway, is a common precursor of the specifying derivatives and is well known for its various functions in biosystems. Mast cells contain high levels of gangliosides; however, the involvement of GM3 in mast cell sensitivity is unclear. Therefore, in this study, we elucidated the role of ganglioside GM3 in mast cells and skin inflammation. GM3 synthase (GM3S)‐deficient mast cells showed cytosolic granule topological changes and hyperactivation upon IgE‐DNP stimulation without affecting proliferation and differentiation. Additionally, inflammatory cytokine levels increased in GM3S‐deficient bone marrow–derived mast cells (BMMC). Furthermore, GM3S‐KO mice and GM3S‐KO BMMC transplantation showed increased skin allergic reactions. Besides mast cell hypersensitivity caused by GM3S deficiency, membrane integrity decreased and GM3 supplementation rescued this loss of membrane integrity. Additionally, GM3S deficiency increased the phosphorylation of p38 mitogen‐activated protein kinase. These results suggest that GM3 increases membrane integrity, leading to the suppression of the p38 signalling pathway in BMMC and contributing to skin allergic reaction.

哺乳類の寒冷適応における褐色脂肪組織の役割
加藤(鈴木) 美羅; 岡松優子
低温科学, 81, 99, 108, Mar. 2023, [Peer-reviewed], [Lead author]
Japanese, Scientific journal

Endothelial ganglioside GM3 regulates angiogenesis in solid tumors
Mira Suzuki; Masaki Nagane; Kazuhiro Kato; Akinori Yamauchi; Takuto Shimizu; Hiroko Yamashita; Naoyuki Aihara; Junichi Kamiie; Nagako Kawashima; Shokichi Naito; Tadashi Yamashita
Biochemical and Biophysical Research Communications, 569, 10, 16, Elsevier BV, Sep. 2021, [Peer-reviewed], [Lead author]
English, Scientific journal

Tumor hypoxia regulates ganglioside GM3 synthase, which contributes to oxidative stress resistance in malignant melanoma
Takuto Shimizu; Masaki Nagane; Mira Suzuki; Akinori Yamauchi; Kazuhiro Kato; Nagako Kawashima; Yuki Nemoto; Takuya Maruo; Yasushi Kawakami; Tadashi Yamashita
Biochimica et Biophysica Acta (BBA) - General Subjects, 1864, 12, 129723, 129723, Elsevier BV, Dec. 2020, [Peer-reviewed]
English, Scientific journal

■ Lectures, oral presentations, etc.

脂肪組織リモデリングにおいてIgGが蓄積する
加藤美羅; 玉越雪乃; 坪田あゆみ; 木村和弘; 岡松優子
第97回日本生化学会大会, 07 Nov. 2024, Japanese, Oral presentation
47551824

マウス授乳期の抗生剤投与は子のベージュ脂肪細胞出現と短鎖脂肪酸生成を抑制する
塚田杏樹; 加藤美羅; 二川瑛実; 土生優妃; 高橋菜摘; 岡松優子
第97回日本生化学会大会, 06 Nov. 2024, Japanese, Poster presentation

脂肪組織のリモデリング過程においてIgGが蓄積する
加藤美羅; 玉越雪乃; 坪田あゆみ; 木村和弘; 岡松優子
第167回日本獣医学会学術集会, 13 Sep. 2024, Japanese, Oral presentation
47551824

母マウスの授乳中の高脂肪食摂取が子の成長後のベージュ脂肪細胞誘導と食餌性肥満に与える影響
糸井太希斗; 塚田杏樹; Bong Soo Seok; 松本爽子; Zibo Yang; 加藤美羅; 岡松優子
第167回日本獣医学会学術集会, 13 Sep. 2024, Japanese, Oral presentation

授乳期のビタミンA 欠乏が子のベージュ脂肪細胞の出現と血管新生に与える影響
加藤美羅; 塚田杏樹; 二川瑛実; 稲波修; 木村和弘; 岡松優子
第61 回日本生化学会北海道支部例会日本生化学会北海道支部・日本生物物理学会北海道支部合同シンポジウム, 20 Jul. 2024, Japanese, Oral presentation
20 Jul. 2024 - 20 Jul. 2024

授乳期母マウスの抗生剤摂取が子のベージュ脂肪細胞と腸内環境に与える影響
塚田杏樹; 加藤美羅; 二川瑛実; 土生優妃; 高橋菜摘; 木村和弘; 岡松優子
第61 回日本生化学会北海道支部例会日本生化学会北海道支部・日本生物物理学会北海道支部合同シンポジウム, 20 Jul. 2024, Japanese, Poster presentation
20 Jul. 2024 - 20 Jul. 2024

Acute Food Intake Induced Thermogenesis in Brown Adipose Tissue in Mice
Bong Soo Seok; Mira Kato-Suzuki; Anju Tsukada; Zibo Yang; Yukino Tamakoshi; Yuko Okamatsu-Ogura; Kazuhiro Kimura
The 101st Annual Meeting of The Physiological Society of Japan, English, Poster presentation
28 Mar. 2024 - 30 Mar. 2024

授乳期マウスへの高脂肪食給餌は仔の成長後のβ3アドレナリン受容体刺激依存性ベージュ脂肪細胞誘導能を低下させる
糸井太希斗, 岡松優子, 塚田杏樹, 加藤(鈴木)美羅, 木村和弘
第46回日本分子生物学会年会
27 Nov. 2023 - 01 Dec. 2023

マウスにおいて乳子期のベージュ脂肪細胞は腸内細菌叢の形成と関連して誘導される
塚田杏樹, 岡松優子, 鈴木美羅, 二川瑛実, 加藤祐子, 土生優妃, 高橋菜摘, 石塚敏, 園山慶, 木村和弘
第46回日本分子生物学会年会, Japanese, Poster presentation
27 Nov. 2023 - 01 Dec. 2023

母マウスの授乳中の高脂肪食摂取は仔の成長後のベージュ脂肪細胞誘導能を低下させる
糸井太希斗; 岡松優子; 塚田杏樹; 加藤(鈴木)美羅; 木村和弘
第44回日本肥満学会, Japanese, Poster presentation
25 Nov. 2023 - 26 Nov. 2023

シリアンハムスターにおける褐色脂肪組織の生後形成
加藤(鈴木)美羅
学術変革領域研究A [冬眠生物学2.0] 若手領域会議, Japanese, Oral presentation
11 Oct. 2023 - 12 Oct. 2023

Neurotrophic factor-3 and Neurotrophic factor-4/5 regulate proliferation and differentiation of adipocyte progenitor in rodents
Xu Shucheng; Yoshifumi Murakita; Mira Kato; Takito Itoi; Yuko Okamatsu-Ogura; Kazuhiro Kimura
Sapporo Summer Symposium for One Health 2023, English, Poster presentation
14 Sep. 2023 - 15 Sep. 2023

Administration of antibiotic during lactation suppresses beige adipocyte induction in preweaning mice
Anju Tsukada; Mira Kato-Suzuki; Yuko Okamatsu-Ogura; Kazuhiro Kimura
Sapporo Summer Symposium for One Health 2023, English, Poster presentation
14 Sep. 2023 - 15 Sep. 2023

The role of Cholinergic Anti-inflammatory Pathway in Diet-induced Thermogenesis in Brown Adipose Tissue
Bong Soo Seok; Mira Kato-Suzuki; Anju Tsukada; Zibo Yang; Yukino Tamakoshi; Yuko Okamatsu-Ogura; Kazuhiro Kimura
Sapporo Summer Symposium for One Health 2023, English, Poster presentation
14 Sep. 2023 - 15 Sep. 2023

マウスにおいて授乳期の抗生剤投与は子のベージュ脂肪細胞出現を抑制する
塚田杏樹; 岡松優子; 鈴木美羅; 二川瑛実; 加藤祐子; 土生優妃; 高橋菜摘; 石塚敏; 園山慶; 木村和弘
第166回日本獣医学会学術集会, Japanese, Oral presentation
05 Sep. 2023 - 08 Sep. 2023

母親のビタミンA欠乏食摂取は子のベージュ脂肪細胞の出現を抑制する
加藤(鈴木)美羅; 岡松優子; 塚田杏樹; 二川瑛実; 稲波修; 木村和弘
第166回日本獣医学会学術集会, Japanese, Oral presentation
05 Sep. 2023 - 08 Sep. 2023

Role of gut microbiota formation in the induction of beige adipocytes in pre-weaning mice
塚田杏樹; 岡松優子; 鈴木美羅; 二川瑛実; 加藤祐子; 土生優妃; 高橋菜摘; 石塚敏; 園山慶; 木村和弘
日本生理学会第100回記念大会, English, Poster presentation
14 Mar. 2023 - 16 Mar. 2023

褐色脂肪組織の形成・増生時にビメンチンのチロシン残基がリン酸化される
加藤(鈴木)美羅; 岡松優子; 玉越雪乃; 坪田あゆみ; 小林純子; 木村和弘
Free Radical School 2022, Japanese, Oral presentation
23 Feb. 2023 - 24 Feb. 2023

マウス乳仔期の抗生剤暴露は腸内細菌叢形成とベージュ脂肪細胞の出現を抑制する
塚田杏樹; 岡松優子; 鈴木美羅; 二川瑛実; 加藤祐子; 土生優妃; 高橋菜摘; 石塚敏; 園山慶; 木村和弘
第43回日本肥満学会, Japanese, Oral presentation
02 Dec. 2022 - 03 Dec. 2022

母体のビタミンA欠乏は仔のベージュ脂肪細胞の出現を抑制する
鈴木美羅; 岡松優子; 塚田杏樹; 二川瑛実; 木村和弘
第43回日本肥満学会, Japanese, Oral presentation
02 Dec. 2022 - 03 Dec. 2022

褐色脂肪組織の形成・増生に伴いビメンチンのチロシン残基がリン酸化される
鈴木美羅; 岡松優子; 玉越雪乃; 坪田あゆみ; 小林純子; 木村和弘
第45回日本分子生物学会年会, Japanese, Poster presentation
30 Nov. 2022 - 02 Dec. 2022

Maternal vitamin A deficiency suppresses browning of white adipose tissue in offspring
Suzuki M; Tsukada A; Futagawa E; Okamatsu-Ogura Y; Kimura K
Sapporo Summer Symposium for One Health 2022, English, Poster presentation
14 Sep. 2022 - 15 Sep. 2022

ハムスターの褐色脂肪組織の生後発達に伴いビメンチンのチロシン残基がリン酸化される
鈴木美羅; 玉越雪乃; 坪田あゆみ; 小林純子; 岡松優子; 木村和弘
第165回日本獣医学会学術集会, Japanese
06 Sep. 2022 - 08 Sep. 2022

褐色脂肪組織の形成・増生時にビメンチンのチロシン残基がリン酸化される
鈴木美羅; 玉越雪乃; 坪田あゆみ; 小林純子; 岡松優子; 木村和弘
第58回日本生化学会北海道支部例会, Japanese, Oral presentation
09 Jul. 2022 - 09 Jul. 2022

血管内皮細胞の糖脂質ガングリオシドGM3は血管新生を制御する
鈴木美羅; 永根大幹; 中西勇貴; 相原尚之; 上家潤一; 山下匡
第73回日本酸化ストレス学会, Japanese, Oral presentation
06 Oct. 2020 - 07 Oct. 2020

3-ヒドロキシ酪酸を用いた糖質制限を伴わないケトン体治療は抗腫瘍効果を示す
佐藤由佳; 加藤千博; 佐藤沙菜; 鈴木美羅; 永根大幹; 山下匡; 石原孝也; 石原直忠; 佐藤拓巳
第163回日本獣医学会学術集会, Japanese, Oral presentation
14 Sep. 2020 - 30 Sep. 2020

血管内皮細胞の糖脂質ガングリオシドGM3はERKの活性化を抑制することで腫瘍血管新生を制御する
鈴木美羅; 永根大幹; 中西勇貴; 山下啓子; 相原尚之; 上家潤一; 川島永子; 内藤正吉; 山下匡
第163回日本獣医学会学術集会, Japanese, Oral presentation
14 Sep. 2020 - 30 Sep. 2020

血管内皮細胞のガングリオシドGM3は腫瘍血管新生を制御する
鈴木美羅; 永根大幹; 中西勇貴; 相原尚之; 上家潤一; 山下匡
第162回日本獣医学会学術集会, Japanese, Oral presentation
10 Sep. 2019 - 12 Sep. 2019

Endothelial ganglioside GM3 regulates angiogenesis of solid tumor
Suzuki M; Nagane M; Nakanishi Y; Yamashita T
The 9th Biennial Meeting of Society for Free Radical Research-Asia, English, Poster presentation
04 Apr. 2019 - 07 Apr. 2019

血管内皮細胞のガングリオシドGM3は腫瘍血管新生を制御する
鈴木美羅; 永根大幹; 中西勇貴; 山下匡
第26回日本血管生物医学会, Japanese, Poster presentation
07 Dec. 2018 - 08 Dec. 2018

血管内皮細胞のガングリオシドGM3は腫瘍血管新生を制御する
鈴木美羅; 永根大幹; 中西勇貴; 山下匡
Free Radical School 2018, Japanese, Poster presentation
03 Aug. 2018 - 05 Aug. 2018

■ Research Themes

脂肪組織におけるIgG蓄積の生理的意義の解明ー新たな抗肥満戦略に向けた基礎研究
科学研究費助成事業
Jul. 2024 - Mar. 2026
加藤美羅
日本学術振興会, 研究活動スタート支援, 北海道大学, Principal investigator, 24K23822