Researcher Database
Last Updated :2024/07/25
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Profile and Settings
Affiliation
Degree
Profile and Settings
Name (Japanese)
M. M.Name (Kana)
Mahadeva SwamyName
202201001804869147
Affiliation
Achievement
Research Interests
Research Areas
Research Experience
- 2022/04 - Today Visiting scientist, RIKEN
- 2022/03 - Today Assistant professor, Faculty of Advanced Life Science, Hokkaido University
- 2019/04 - 2022/02 Research scientist, RIKEN
- 2018/05 - 2019/01 Academic researcher, Hokkaido University
- 2012/05 - 2014/08 Research assistant, JNCASR
Education
- 2014/10 - 2018/03 Doctoral degree, Graduate School of Life Science, Hokkaido University
- 2009/07 - 2011/06 Master's degree, University of Mysore
- 2006/06 - 2009/05 Bachelor's degree, University of Mysore
Awards
- 2021/10 Best poster award RIKEN BDR retreat-2021
- 2018/10 Japan Student Services Organization (JASSO) scholarship award
- 2014/10 Japan government MEXT scholarship award
Published Papers
- Mahadeva M. M. Swamy, Yuta Murai, Kenji Monde, Setsuko Tsuboi, Aravind K. Swamy, Takashi JinACS Applied Materials & Interfaces 16 17253 - 17266 1944-8244 2024/04/01 [Refereed]
- Stereochemistry‐activity relationship of ceramide‐induced exosome production to clear amyloid‐β in Alzheimer's diseaseMariam Abdelrasoul, Kohei Yuyama, Mahadeva M. M. Swamy, Yuta Murai, Kenji MondeChirality 35 (9) 577 - 585 2023/04 [Refereed]
- Sajeer Koolath, Yuta Murai, Tomoya Suzuki, Mahadeva M, M. Swamy, Seigo Usuki, Kenji MondeACS Med. Chem. Lett. in press (9) 1237 - 1241 1948-5875 2023 [Refereed]
- A near-infrared fluorescent long-chain fatty acid toward optical imaging of cardiac metabolism in living miceMahadeva M. M. Swamy, Mohamad Zarif Mohd, Zubir, Mutmainah, Setsuko Tsuboi, Yuta Murai, Kenji Monde, Ken-ichi Hiranoc, Takashi JinAnalyst 147 (19) 4206 - 4212 2022/08 [Refereed]
- Shortwave-infrared (SWIR) emitting annexin V for high-contrast fluorescence molecular imaging of tumor apoptosis in living miceMahadeva M. M. Swamy, Setsuko Tsuboi, Yuta Murai, Kenji Monde, Takashi JinRSC Advances 12 (30) 19632 - 19639 2022/06 [Refereed]
- Mahadeva M. M. Swamy, Yuta Murai, Kenji Monde, Setsuko Tsuboi, Takashi JinBioconjugate Chemistry 32 (8) 1541 - 1547 2021/08/18 [Refereed]
Recently, shortwave-infrared (SWIR) fluorescence imaging for the optical diagnostics of diseases has attracted much attention as a new noninvasive imaging modality. For this application, the development of SWIR molecular imaging probes with high biocompatibility is crucial. Although many types of biocompatible SWIR fluorescent probes based on organic dyes have been reported, there are no SWIR-emitting molecular imaging probes that can be used for the detection of specific biomolecules in vivo. To apply SWIR-emitting molecular imaging probes to biomedical fields, we developed a biocompatible SWIR fluorescent dye based on π-conjugation extended indocyanine green (ICG), where ICG is the only approved near-infrared dye by the US Food and Drug Administration (FDA) for use in the clinic. Using the π-conjugation extended ICG, we prepared SWIR molecular imaging probes that can be used for in vivo tumor imaging. Herein, we demonstrate noninvasive SWIR fluorescence imaging of human epidermal growth factor receptor 2 (HER2)-positive and epidermal growth factor receptor (EGFR)-positive breast tumors using π-conjugation extended ICG and monoclonal antibody conjugates. The presented π-conjugation extended ICG analog probes will be a breakthrough to apply SWIR fluorescence imaging in biomedical fields. - Daurichromenic acid from the Chinese traditional medicinal plant Rhododendron dauricum inhibits sphingomyelin synthase and Aβ aggregationHadya Virupaksha Deepak, Mahadeva M. M. Swamy, Yuta Murai, Yoshiko Suga, Masaki Anetai, Takuro Yo, Masahiro Kuragano, Koji Uwai, Kiyotaka Tokuraku, Kenji MondeMolecules 25 (18) 4077 - 4088 2020/09/07 [Refereed]
- Determination of the absolute configurations and sensory properties of the enantiomers of a homologous series (C6-C10) of 2-mercapto-4-alkanonesChristiane Kiske, Anja Devenie Riegel, Ronja Hopf, Anna Kvind, Iulia Poplacean, Tohru Taniguchi, Mahadeva M. M. Swamy, Kenji Monde, Wolfgang Eisenreich, Karl-Heinz EngelJ. Agric. Food Chem. 64 (4) 1187 - 1196 2019/01/03 [Refereed]
- Structure-inspired design of a sphingolipid mimic sphingosine-1-phosphate receptor agonist from a naturally occurring sphingomyelin synthase inhibitorMahadeva M. M. Swamy, Yuta Murai, Yusuke Ohno, Akio Kihara, Susumu Mitsutake, Yasuyuki Igarashi, Jian Yu, Min Yao, Yoshiko Suga, Masaki Anetai, Kenji MondeChem. Commun. 54 (90) 12758 - 12761 2018/11/08 [Refereed]
- Chemical and genetic rescue of an ep300 knockdown model for Rubinstein Taybi Syndrome in zebrafishAswini Babu, Mageshi Kamaraj, Moumita Basu, Debanjan Mukherjee, Shruti Kapoor, Shashi Ranjan, Mahadeva M. M. Swamy, Stephanie Kaypee, Vinod Scaria, Tapas K. Kundu, Chetana SachidanandanBiochim. Biophys. Acta 1864 (4) 1203 - 1215 2018/04 [Refereed]
- Inhibition of histone/lysine acetyltransferase activity kills CoCl2-treated and hypoxia-exposed gastric cancer cells and reduces their invasivenessSuvasmita Rath, Lopamudra Das, Shrikant Babanrao Kokate, Nilabh Ghosh, Pragyesh Dixi, Niranjan Rou, Shivaram P. Singh, Subhasis Chattopadhyay, Hassan Ashktorab, Duane T. Smoo, Mahadeva M. M. Swamy, Tapas K. Kundu, Sheila E. Crowe, Asima BhattacharyyaInt. J. Biochem. Cell Biol. 82 28 - 40 2017/01 [Refereed]
- Reducing molecular flexibility by cyclization for elucidation of absolute configuration by CD calculations: Daurichromenic acidAttila Mandi, Mahadeva M. M. Swamy, Tohru Taniguchi, Masaki Anetai, Kenji MondeChirality 28 (6) 453 - 459 2016/06 [Refereed]
- Stereochemistry of a rhododaurichromanic acid derivativeMahadeva M. M. Swamy, Attila Mándi, Masaki Anetai, Kenji MondeNat. Prod. Commun. 11 (2) 193 - 195 2016/02 [Refereed]
- Hydrazinobenzoylcurcumin inhibits androgen receptor activity and growth of castration-resistant prostate cancer in miceMin Wu, Sahn-Ho Kim, Indrani Datta, Albert Levin, Gregory Dyson, Jing Li, Stephanie Kaypee, Mahadeva M. M. Swamy, Nilesh Gupta, Ho Jeong Kwon, Mani Menon, Tapas K. Kundu, G. Prem-Veer ReddyOncotarget 6 (8) 6136 - 6150 2015/03 [Refereed]
- Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkersFeng Li, Muthu K, Shanmugam, Kodappully Sivaraman Siveen, Fan Wang, Tina H. Ong, Ser Yue Loo, Mahadeva M. M. Swamy, Somnath Mandal, Alan Prem Kumar, Boon Cher Goh, Tapas Kundu, Kwang Seok Ahn, Ling Zhi Wang, Kam Man Hui, Gautam SethiOncotarget 6 (7) 5147 - 5163 2015/03 [Refereed]
- Naphthoquinone-mediated inhibition of lysine acetyltransferase KAT3B/p300, basis for non-toxic inhibitor synthesisMohankrishna Dalvoy Vasudevarao, Pushpak Mizar, Sujata Kumari, Somnath Mandal, Soumik Siddhanta, Mahadeva M. M. Swamy, Stephanie Kaypee, Ravindra C Kodihalli, Amrita Banerjee, Chandrabhas Naryana, Dipak Dasgupta, Tapas K. KunduJ. Biol. Chem. 289 (11) 7702 - 7717 2014/03 [Refereed]
Books etc
- Garcinol and its role in chronic diseasesAmit K. Behera, Mahadeva M. M. Swamy, Nagashayana, Tapas K. Kundu
Adv. Exp. Med. Biol. 2016/09
Industrial Property Rights
- 特願2021-041717:Complexes and shortwave-infrared fluorescent probes, manufacturing methods and thereof 2021年Jin Takashi, M. M. Mahadeva Swamy, Monde Kenji, Murai Yuta RIKEN, Hokkaido University
- 特願2017-236847:Daurichromenic acid, naturally occurring SMS inhibitor 2017年Monde Kenji, Murai Yuta, M. M. Mahadeva Swamy Hokkaido University
- 特願2017-236846:Ginkgolic acid, naturally occurring SMS inhibitor 2017年Monde Kenji, Murai Yuta, M. M. Mahadeva Swamy Hokkaido University