Researcher Profile and Settings

Affiliation

• Faculty of Health Sciences　Health Sciences　Department of Rehabilitation Science

Job Title

• Lecturer

Research funding number

• 90638280

J-Global ID

• 201301095268987586

Research Interests

• リハビリテーション   作業療法学   神経心理学   高次脳機能障害学   

Research Areas

• Life sciences / Rehabilitation science

Educational Organization

•  Bachelor's degree program　Departments of Health Sciences, School of Medicine
•  Master's degree program　Graduate School of Health Sciences
•  Doctoral (PhD) degree program　Graduate School of Health Sciences

Academic & Professional Experience

• 2021/09 - Today 北海道大学 脳科学研究教育センター 基幹教員
• 2020/04 - Today 北海道大学大学院保健科学研究院 リハビリテーション科学分野 講師
• 2015/04 - Today Hokkaido University Hospital Department of rehabilitation
• 2019/12 - 2020/03 Hokkaido University Faculty of Health Sciences
• 2018/04 - 2019/11 Faculty of Health Sciences, Hokkaido University Department of Functioning and Disability Assistant Professor
• 2017/03 - 2018/03 Faculty of Health Sciences, Hokkaido University Department of Functioning and Disability Assistant Professor
• 2015/04 - 2017/03 Hokkaido University Faculty of Health Sciences
• 2012/04 - 2015/03 Hokkaido Bunkyo University assistant professor

Education

• 2012/04 - 2015/03  Hokkaido University  Graduate School of Health Sciences
• 2010/04 - 2012/03  Hokkaido University  Graduate School of Health Sciences
• 2006/04 - 2010/03  Hokkaido University

Research Activities

Published Papers

• Prospective and Retrospective Metacognitive Abilities and Their Association with Impaired Self-awareness in Patients with Traumatic Brain Injury

  Kazuki Yoshida, Daisuka Sawamura, Keita Ogawa, Takuroh Mototani, Katsunori Ikoma, Shinya Sakai

  Journal of Cognitive Neuroscience 35 (12) 1960 - 1971 0898-929X 2023/12/01 [Refereed]
   

  Abstract Metacognitive impairment often occurs in patients with traumatic brain injury (TBI) and is associated with clinical problems. The aim of this study was to clarify the pathology of metacognitive impairment in TBI patients using a behavioral task, clinical assessment of self-awareness, and lesion-symptom mapping. Metacognitive abilities of TBI patients and healthy controls were assessed using a modified perceptual decision-making task. Self-awareness was assessed using the Patient Competency Rating Scale and the Frontal Systems Behavior Scale. The associations between estimated metacognitive abilities, self-awareness, and neuropsychological test results were examined. The correspondence between metacognitive disabilities and brain lesions was explored by ROI-based lesion-symptom mapping using structural magnetic resonance images. Overall, 25 TBI patients and 95 healthy controls were included in the analyses. Compared with that in healthy controls, the prospective metacognitive ability of TBI patients was lower, with metacognitive evaluations revealing a bias toward overestimating their abilities. Retrospective metacognitive ability showed a negative correlation with self-awareness but not with neuropsychological test results. In the lesion-symptom mapping analysis, the left pFC was associated with lower retrospective metacognitive ability. This study contributes to a better understanding of the pathology of metacognitive and self-awareness deficits in TBI patients and may explain the cause of impaired realistic goal setting and adaptive behavior in these patients.
• Detecting inattentiveness caused by mind-wandering during a driving task: A behavioral study

  Kazuki Yoshida, Daisuke Sawamura, Mikio Yagi, Yu Nakashima, Ryuji Saito, Nao Yamamura, Katsuhiko Ogasawara, Shinya Sakai

  Applied Ergonomics 106 103892 - 103892 0003-6870 2023/01 [Refereed]
  
• Explicit and implicit attitudes toward smoking: Dissociation of attitudes and different characteristics for an implicit attitude in smokers and nonsmokers

  Xinyue Gao, Daisuke Sawamura, Ryuji Saito, Yui Murakami, Rika Yano, Satoshi Sakuraba, Susumu Yoshida, Shinya Sakai, Kazuki Yoshida

  PLOS ONE 17 (10) e0275914 - e0275914 2022/10/10 [Refereed]
   

  Smoking is a global health risk for premature death and disease. Recently, addictive behaviors, like smoking, were considered to be guided by explicit and implicit processes. The existence of a dissociation between the two attitudes in nonsmokers and the causes of the differences in implicit attitudes toward smoking have not been fully investigated. We investigated the explicit and implicit attitudes toward smoking via a self-reported scale and the single category implicit association test (SC-IAT), respectively, among undergraduate and graduate health sciences students. In addition, we applied the drift-diffusion model (DDM) on the SC-IAT and examined the behavioral characteristics that caused differences in implicit attitude toward smoking between smokers and nonsmokers. The results showed the existence of a dissociation between explicit and implicit attitudes toward smoking among nonsmokers. In addition, nonsmokers had a higher decision threshold than smokers and a higher drift rate in the condition where negative words were associated with smoking. Nonsmokers engaged in SC-IAT with more cautious attitudes and responded more easily in a negative condition since it was consistent with their true attitudes. Conversely, smokers did not show a significant difference in the drift rate between the conditions. These results suggested that the differences in an implicit attitude between smokers and nonsmokers were caused by differences in evidence accumulation speed between the positive and negative conditions. The existence of dissociation between implicit and explicit attitudes toward smoking may indicate the difficulty of measuring true attitude in nonsmokers in a questionnaire survey. Additionally, the DDM results explained the difference of implicit attitude between smokers and nonsmokers; it may provide information on the mechanisms of addictive behaviors and a basis for therapy. However, whether these results are affected by cultural differences requires further investigation.
• The Role of the Ventromedial Prefrontal Cortex in Preferential Decisions for Own- and Other-Age Faces

  Ayahito Ito, Kazuki Yoshida, Ryuta Aoki, Toshikatsu Fujii, Iori Kawasaki, Akiko Hayashi, Aya Ueno, Shinya Sakai, Shunji Mugikura, Shoki Takahashi, Etsuro Mori

  Frontiers in Psychology 13 822234 - 822234 2022/03/11 [Refereed]
   

  Own-age bias is a well-known bias reflecting the effects of age, and its role has been demonstrated, particularly, in face recognition. However, it remains unclear whether an own-age bias exists in facial impression formation. In the present study, we used three datasets from two published and one unpublished functional magnetic resonance imaging (fMRI) study that employed the same pleasantness rating task with fMRI scanning and preferential choice task after the fMRI to investigate whether healthy young and older participants showed own-age effects in face preference. Specifically, we employed a drift-diffusion model to elaborate the existence of own-age bias in the processes of preferential choice. The behavioral results showed higher rating scores and higher drift rate for young faces than for older faces, regardless of the ages of participants. We identified a young-age effect, but not an own-age effect. Neuroimaging results from aggregation analysis of the three datasets suggest a possibility that the ventromedial prefrontal cortex (vmPFC) was associated with evidence accumulation of own-age faces; however, no clear evidence was provided. Importantly, we found no age-related decline in the responsiveness of the vmPFC to subjective pleasantness of faces, and both young and older participants showed a contribution of the vmPFC to the parametric representation of the subjective value of face and functional coupling between the vmPFC and ventral visual area, which reflects face preference. These results suggest that the preferential choice of face is less susceptible to the own-age bias across the lifespan of individuals.
• Effect of Audiovisual Cross-Modal Conflict during Working Memory Tasks: A Near-Infrared Spectroscopy Study

  Jiahong Cui, Daisuke Sawamura, Satoshi Sakuraba, Ryuji Saito, Yoshinobu Tanabe, Hiroshi Miura, Masaaki Sugi, Kazuki Yoshida, Akihiro Watanabe, Yukina Tokikuni, Susumu Yoshida, Shinya Sakai

  Brain Sciences 12 (3) 349 - 349 2022/03/03 [Refereed]
   

  Cognitive conflict effects are well characterized within unimodality. However, little is known about cross-modal conflicts and their neural bases. This study characterizes the two types of visual and auditory cross-modal conflicts through working memory tasks and brain activities. The participants consisted of 31 healthy, right-handed, young male adults. The Paced Auditory Serial Addition Test (PASAT) and the Paced Visual Serial Addition Test (PVSAT) were performed under distractor and no distractor conditions. Distractor conditions comprised two conditions in which either the PASAT or PVSAT was the target task, and the other was used as a distractor stimulus. Additionally, oxygenated hemoglobin (Oxy-Hb) concentration changes in the frontoparietal regions were measured during tasks. The results showed significantly lower PASAT performance under distractor conditions than under no distractor conditions, but not in the PVSAT. Oxy-Hb changes in the bilateral ventrolateral prefrontal cortex (VLPFC) and inferior parietal cortex (IPC) significantly increased in the PASAT with distractor compared with no distractor conditions, but not in the PVSAT. Furthermore, there were significant positive correlations between Δtask performance accuracy and ΔOxy-Hb in the bilateral IPC only in the PASAT. Visual cross-modal conflict significantly impairs auditory task performance, and bilateral VLPFC and IPC are key regions in inhibiting visual cross-modal distractors.
• Differences of expected intervention effects between participant-led and facilitator-led preventive care services in Japan

  Shan Yun, Risa Takashima, Kazuki Yoshida, Daisuke Sawamura, Takao Inoue, Shinya Sakai

  Hong Kong Journal of Occupational Therapy 34 (2) 83 - 93 1569-1861 2021/12 [Refereed]
   

  Objective To examine the effect of different management methods on the effectiveness of care preventive programmes for community-dwelling older adults. Methods This study comprised two facilitator-led (FL) and one participant-led (PL) preventive care classes in Japan. All participants received the intervention for approximately 12 weeks. Functional assessments, occupational dysfunctions, and subjective health were measured before and after the interventions. A two-way mixed design analysis of covariance (ANCOVA) was adopted to examine the effect of the interventions, adjusted for previous experiences with preventive care services. The level of significance was set at P < 0.05. Results Fourteen participants in the PL group (76.64 ± 6.48 years, 92.9% women) and 29 participants in the FL group (76.55 ± 5.75 years, 75.9% women) were included in the statistical analysis. ANCOVA showed significant group × time interaction effects in the Five Times Sit-to-Stand Test (FTSST), the Timed Up & Go (TUG), occupational deprivation of the Classification and Assessment of Occupational Dysfunction Scale, and self-rated health. Simple main effect tests showed that the TUG decreased significantly in the PL group, while occupational deprivation and self-rated health scores improved significantly. In contrast, FTSST scores significantly improved in the FL group. Conclusion PL-type management may be more appropriate for preventing social isolation and withdrawal, while FL-type management may be more appropriate for preventing physical frailty. Selecting not only adequate programmes but also an appropriate management type that matches the service purpose can help provide more effective care preventive services.
• Relationship between proficiency level and anxiety-reducing effect in a one-time heart rate variability biofeedback: A randomized controlled trial

  Ryuji Saito, Daisuke Sawamura, Kazuki Yoshida, Shinya Sakai

  Medicine 100 (45) e27742 - e27742 0025-7974 2021/11 [Refereed]
  
• Chopstick operation training with the left non-dominant hand

  Sawamura D, Sakuraba S, Yoshida K, Hasegawa N, Suzuki Y, Yoshida S, Honke T, Sakai S

  Translational Neuroscience 12 (1) 385 - 395 2021/10 [Refereed]
  
• Current practices and factors affecting evidence-based occupational therapy practice for patients with dementia in Japan

  Ai Hasegawa, Risa Takashima, Kazuki Yoshida, Daisuke Sawamura, Waka Murata, Shinya Sakai

  Hong Kong Journal of Occupational Therapy 33 (2) 73 - 81 1569-1861 2020/12 [Refereed]
   

  The rapidly increasing incidence of patients with dementia in Japan is creating an urgent demand for evidence-based occupational therapy (EBOT), which has been reported to improve clinical efficacy. This study aimed to examine the current practice of EBOT for patients with dementia in Japan and clarify factors influencing its application. We conducted an anonymous, self-administered questionnaire survey by mail. The participants were 432 occupational therapists treating patients with dementia at 432 designated medical institutions nationwide. Descriptive statistics were calculated, and multiple regression analysis was performed to clarify the factors influencing the present application of EBOT. The response rate was 31.3%. Among the participants, 46.3% responded ‘somewhat frequently’ or more (5, 6, and 7 on a 7-grade scale) to a question on the frequency of practice of EBOT. Using multiple regression analysis with the stepwise method, we selected the model with the highest degree of fit. This model extracted three factors, namely, ability to understand scientific papers, sufficiency of means of getting information, and availability of advice, which had standardized partial regression coefficients (β) of 0.419, 0.214, and 0.158, respectively. The three factors extracted using the multiple regression analysis indicate that in order to encourage EBOT for patients with dementia, occupational therapists need to acquire reading comprehension skills, so that they can assess the quality of scientific papers. Furthermore, it is important to create environments where they have access to publications and can discuss research with superiors and colleagues.
• The role of the ventromedial prefrontal cortex in automatic formation of impression and reflected impression

  Ito A, Yoshida K, Takeda K, Sawamura D, Murakami Y, Hasegawa A, Sakai S, Izuma K

  Human Brain Mapping 41 (11) 3045 - 3058 2020/03 [Refereed][Not invited]
  
• Focused attention meditation training modifies neural activity and attention: longitudinal EEG data in non-meditators.

  Kazuki Yoshida, Kenta Takeda, Tetsuko Kasai, Shiika Makinae, Yui Murakami, Ai Hasegawa, Shinya Sakai

  Social cognitive and affective neuroscience 15 (2) 215 - 224 2020/02/12 [Refereed][Not invited]
   

  Focused attention meditation (FAM) is a basic meditation practice that cultivates attentional control and monitoring skills. Cross-sectional studies have highlighted high cognitive performance and discriminative neural activity in experienced meditators. However, a direct relationship between neural activity changes and improvement of attention caused by meditation training remains to be elucidated. To investigate this, we conducted a longitudinal study, which evaluated the results of electroencephalography (EEG) during three-stimulus oddball task, resting state, and FAM before and after 8 weeks of FAM training in non-meditators. The FAM training group (n = 17) showed significantly higher P3 amplitude during the oddball task and shorter reaction time for target stimuli compared to that of the control group (n = 20). Furthermore, a significant negative correlation between F4-Oz theta band phase synchrony index (PSI) during FAM and P3 amplitude during the oddball task, and a significant positive correlation between F4-Pz theta band PSI during FAM and P3 amplitude during the oddball task were observed. In contrast, these correlations were not observed in the control group. These findings provide direct evidence of the effectiveness of FAM training and contribute to our understanding of the mechanisms underpinning the effects of meditation on brain activity and cognitive performance.
• Acquisition of chopstick-operation skills with the non-dominant hand and concomitant changes in brain activity

  Daisuke Sawamura, Satoshi Sakuraba, Yumi Suzuki, Masako Asano, Susumu Yoshida, Toshihiro Honke, Megumi Kimura, Yoshiaki Iwase, Yoshitaka Horimoto, Kazuki Yoshida, Shinya Sakai

  Scientific Reports 9 (1) 20397  2019/12 [Refereed][Not invited]
  
• Flow experience enhances the effectiveness of attentional training: A pilot randomized controlled trial of patients with attention deficits after traumatic brain injury

  Yoshida K, Ogawa K, Mototani T, Inagaki Y, Sawamura D, Ikoma K, Sakai S

  NeuroRehabilitation 43 (2) 183 - 193 1053-8135 2018/09 [Refereed][Not invited]
   

  BACKGROUND: Flow is an optimal psychological state when people engage in a training task, and it is a theory explaining the absorbed state.OBJECTIVE: To investigate the additional effect of flow on attention deficits for chronic patients after traumatic brain injury.METHODS: Twenty patients were randomly assigned to the flow group (n = 10) or the control group. Patients performed a video game task, one inducing flow (flow group) and the other not (control group) for 4 weeks, and they were assessed with the flow state scale for occupational tasks (FSSOT) regularly and neuropsychological tests at baseline, after intervention, and at 4 weeks after intervention (follow-up).RESULTS: Although both groups significantly improved their attentional function after intervention, patients in the flow group tended to show more improvement of attention. The effect size of the neuropsychological test of attention was positive, and its value was small to medium. There was a significant positive correlation between improvement of attention and the FSSOT score.CONCLUSIONS: Attention training with induction of the flow was associated with greater improvement of attention. The results of this study may provide provisional evidence of the effectiveness of rehabilitation considering the patient's psychological state.
• Autistic traits modulate the activity of the ventromedial prefrontal cortex in response to female faces

  Murakami Y, Sakai S, Takeda K, Sawamura D, Yoshida K, Hirose T, Ikeda C, Mani H, Yamamoto T, Ito A

  Neuroscience Research 133 28 - 37 2018 [Refereed][Not invited]
   

  Previous findings have revealed abnormal visual attention or processing of faces among individuals with autism spectrum condition (ASC). However, little attention has been paid to the relationship between autistic traits and neural mechanisms associated with representing facial values. Using fMRI, we investigated the patterns of brain activity in the vmPFC and VS in response to faces of elderly males, elderly females, young males, and young females. During fMRI, subjects with a relatively high autism quotient (high group) and those with a relatively low autism quotient (low group) were presented with a face and asked to rate its pleasantness. After fMRI, the subjects were presented with pairs of faces and asked to select the face that they preferred. Our results indicate a dissociable modulatory effect of autistic traits on the vmPFC and VS: The vmPFC activity in the low group was more sensitive to age differences in female faces compared to that in the high group, whereas VS activity did not show differences between groups. These results suggest that, in the BVS, autistic traits selectively modulate the vmPFC activity associated with facial value representation.
• Effect of exposure to short-wavelength light on susceptibility to motion sickness

  Kyungshil Kim, Kazumi Hirayama, Kazuki Yoshida, Rika Yano, Masayuki Abe, Mika Otsuki, Satoshi Sakuraba, Shinya Sakai

  NeuroReport 28 (10) 584 - 589 1473-558X 2017 [Refereed][Not invited]
   

  This randomized cross-over study tested the hypothesis that exposure to short-wavelength light induces symptoms of motion sickness (MS). The study participants were 28 healthy adults (14 women mean age±SD, 25.96±3.11 years). Two stimuli oscillating within a range of 0.4-0.6 Hz were used to induce MS: a blue wave stimulus with short-wavelength light (460 nm) and a green wave stimulus with middle-wavelength light (555 nm). All participants were exposed to both stimuli throughout two separate periods. After a baseline period, participants were exposed to each stimulus three times for 4 min. The Simulator Sickness Questionnaire, a self-report checklist composed of three subscales (Oculomotor, Disorientation, and Nausea), heart rate variability, and electrogastrography were used to measure the degree of symptoms related to MS. A linear mixed-effects model was used for statistical analysis. The results showed significant main effects for Period (P< 0.01), Color (P< 0.01), and Time Point (P< 0.01) scores on the Simulator Sickness Questionnaire Nausea subscale. A post-hoc test indicated that scores on the Nausea subscale were significantly higher after the third exposure to blue light than after the first and second exposures. The linear mixed-effects model showed significant main effects for Color (P< 0.01) with respect to the normogastria/tachygastria ratio. These findings suggest that short-wavelength light induces symptoms of MS, especially gastrointestinal symptoms.
• Milestones for Communication development in Japanese Children with Spinal Muscular Atrophy Type I

  Hoshi Y, Sasaki C, Yoshida K, Sato Y, Kato M, Sakuraba S, Sawamura D, Sakai S

  Journal of Health Sciences 14 115 - 120 2017 [Refereed][Not invited]
  
• Gender differences in ventromedial prefrontal cortex activity associated with valuation of faces

  Ito A, Fujii T, Abe N, Kawasaki I, Hayashi A, Ueno A, Yoshida K, Sakai S, Mugikura S, Takahashi S, Mori E

  Neuroscience 328 194 - 200 0306-4522 2016/07 [Refereed][Not invited]
   

  Psychological studies have indicated that males exhibit stronger preferences for physical attributes in the opposite gender, such as facial attractiveness, than females. However, whether gender differences in mate preference originate from differential brain activity remains unclear. Using functional magnetic resonance imaging (fMRI), we investigated the patterns of brain activity in the ventromedial prefrontal cortex (vmPFC), a region critical for the valuation of faces, in response to elderly male, elderly female, young male, and young female faces. During fMRI, male and female subjects were presented with a face and asked to rate its pleasantness. Following fMRI, the subjects were presented with pairs of faces and asked to select the face that they preferred. We analyzed the vmPFC activity during the pleasantness-rating task according to the gender of the face stimulus (male and female) and the age of the face stimulus (elderly and young). Consistent with the results of previous studies, the vmPFC activity parametrically coded the subjective value of faces. Importantly, the vmPFC activity was sensitive to physical attributes, such as the youthfulness and gender of the faces, only in the male subjects. These findings provide a possible neural explanation for gender differences in mate preference. (C) 2016 IBRO. Published by Elsevier Ltd. All rights reserved.
• Differential activation of the ventromedial prefrontal cortex between male and female givers of social reputation

  Iori Kawasaki, Ayahito Ito, Toshikatsu Fujii, Aya Ueno, Kazuki Yoshida, Shinya Sakai, Shunji Mugikura, Shoki Takahashi, Etsuro Mori

  Neuroscience Research 103 27 - 33 0168-0102 2016/02 [Refereed][Not invited]
   

  Accumulating evidence has shown the profound influence of social reputation on human behavior and has implicated the ventromedial prefrontal cortex (vmPFC) in representing subjective values induced by social interaction. However, little is known regarding how the vmPFC encodes subjective pleasantness induced by social reputation received from others. We used functional magnetic resonance imaging (fMRI) to investigate how the vmPFC in males and females encodes the subjective pleasantness of social reputation received from the same gender and from the opposite gender. Behavioral data showed that positive reputation was perceived to be more pleasant than negative reputation. Intriguingly, both male and female subjects showed greater differences in the pleasantness scores between the positive reputation condition and the negative reputation condition from females than between positive and negative reputations from males. Imaging data revealed that the left vmPFC specifically contributed to the processing of positive reputation. The activity patterns of the vmPFC corresponded to the gender differences in behavior during the processing of social reputation. These results indicate that the vmPFC plays a role in representing the subjective value of positive social reputation and that this region might be a final computational site in a stream of value-based decision-making processes. (C) 2015 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
• Distinct neural correlates of the preference-related valuation of supraliminally and subliminally presented faces

  Ayahito Ito, Nobuhito Abe, Yousuke Kawachi, Iori Kawasaki, Aya Ueno, Kazuki Yoshida, Shinya Sakai, Yoshihiko Matsue, Toshikatsu Fujii

  HUMAN BRAIN MAPPING 36 (8) 2865 - 2877 1065-9471 2015/08 [Refereed][Not invited]
   

  Recent neuroimaging studies have investigated the neural substrates involved in the valuation of supraliminally presented targets and the subsequent preference decisions. However, the neural mechanisms of the valuation of subliminally presented targets, which can guide subsequent preference decisions, remain to be explored. In the present study, we determined whether the neural systems associated with the valuation of supraliminally presented faces are involved in the valuation of subliminally presented faces. The subjects were supraliminally and subliminally presented with faces during functional magnetic resonance imaging (fMRI). Following fMRI, the subjects were presented with pairs of faces and were asked to choose which face they preferred. We analyzed brain activation by back-sorting the fMRI data according to the subjects' choices. The present study yielded two main findings. First, the ventral striatum and the ventromedial prefrontal cortex predict preferences only for supraliminally presented faces. Second, the dorsomedial prefrontal cortex may predict preferences for subliminally presented faces. These findings indicate that neural correlates of the preference-related valuation of faces are dissociable, contingent upon whether the subjects consciously perceive the faces. Hum Brain Mapp 36:2865-2877, 2015. (c) 2015 Wiley Periodicals, Inc.
• Flow Experience During Attentional Training Improves Cognitive Functions in Patients with Traumatic Brain Injury: An Exploratory Case Study

  Kazuki Yoshida, Daisuke Sawamura, Keita Ogawa, Katsunori Ikoma, Kiyoshi Asakawa, Taro Yamauchi, Shinya Sakai

  Hong Kong Journal of Occupational Therapy 24 (2) 81 - 87 1569-1861 2014/12 [Refereed][Not invited]
   

  Objective/Background: Flow is the holistic experience that occurs when an individual acts with total involvement. The objective of this study was to examine the effects of attention training that induces flow experience for patients with attention-deficit disorder after traumatic brain injury (TBI). Methods: A two-patient case report with a within-subject AB design was conducted. Two patients with attention deficit after TBI were recruited for attention training. Two types of video game tasks for attention training were created, one inducing flow (flow task) and the other not (control task). Patient A performed the flow task for 14 days after receiving general occupational therapy (OT) for 11 days. Patient B performed the flow task for 15 days after performing the control task for 10 days. We examined training effects using neuropsychological tests. The Flow State Scale for Occupational Tasks was administered to identify the patient's flow state. To evaluate the training effect, we used visual analysis, the two-standard deviation band method, and effect-size analyses. Results: Both Patient A and Patient B showed improvement on the Continuous Performance Test, Symbol Digit Modalities Test, and Moss Attention Rating Scale after the flow task. Patient B also showed improvement on the Trail Making Test. Conclusion: The results for Patient A suggested that the flow task was more effective than general OT for improving attention deficits. Moreover, the results for Patient B suggested that the flow task was more effective than the control task. Attention training inducing flow experience may thus facilitate improvement of attention. Copyright (C) 2015, Hong Kong Occupational Therapy Association. Published by Elsevier (Singapore) Pte Ltd. All rights reserved.
• Brain activity during the flow experience: A functional near-infrared spectroscopy study

  Kazuki Yoshida, Daisuke Sawamura, Yuji Inagaki, Keita Ogawa, Katsunori Ikoma, Shinya Sakai

  Neuroscience Letters 573 30 - 34 0304-3940 2014/06 [Refereed][Not invited]
   

  Flow is the holistic experience felt when an individual acts with total involvement. Although flow is likely associated with many functions of the prefrontal cortex (PFC), such as attention, emotion, and reward processing, no study has directly investigated the activity of the PFC during flow. The objective of this study was to examine activity in the PFC during the flow state using functional near-infrared spectroscopy (fNIRS). Twenty right-handed university students performed a video game task under conditions designed to induce psychological states of flow and boredom. During each task and when completing the flow state scale for occupational tasks, change in oxygenated hemoglobin (oxy-Hb) concentration in frontal brain regions was measured using fNIRS. During the flow condition, oxy-Hb concentration was significantly increased in the right and left ventrolateral prefrontal cortex. Oxy-Hb concentration tended to decrease in the boredom condition. There was a significant increase in oxy-Hb concentration in the right and left dorsolateral prefrontal cortex, right and left frontal pole areas, and left ventrolateral PFC when participants were completing the flow state scale after performing the task in the flow condition. In conclusion, flow is associated with activity of the PFC, and may therefore be associated with functions such as cognition, emotion, maintenance of internal goals, and reward processing. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
• Neural activity associated with enhanced facial attractiveness by cosmetics use

  Aya Ueno, Ayahito Ito, Iori Kawasaki, Yousuke Kawachi, Kazuki Yoshida, Yui Murakami, Shinya Sakai, Toshio Iijima, Yoshihiko Matsue, Toshikatsu Fujii

  Neuroscience Letters 566 142 - 146 0304-3940 2014/04 [Refereed][Not invited]
   

  Previous psychological studies have shown that make-up enhances facial attractiveness. Although neuroimaging evidence indicates that the orbitofrontal cortex (OFC) shows greater activity for faces of attractive people than for those of unattractive people, there is no direct evidence that the OFC also shows greater activity for the face of an individual wearing make-up than for the same face without make-up. Using functional magnetic resonance imaging (fMRI), we investigated neural activity while subjects viewed 144 photographs of the same faces with and without make-up (48 with make-up, 48 without make-up, and 48 scrambled photographs) and assigned these faces an attractiveness rating. The behavioral data showed that the faces with make-up were rated as more attractive than those without make-up. The imaging data revealed that the left OFC and the right hippocampus showed greater activity for faces with make-up than for those without make-up. Furthermore, the activities of the right anterior cingulate cortex, left hippocampus, and left OFC increased with increasing facial attractiveness resulting from cosmetics use. These results provide direct evidence of the neural underpinnings of cosmetically enhanced facial attractiveness. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
• Active inhibition of task-irrelevant sounds and its neural basis in patients with attention deficits after traumatic brain injury

  Daisuke Sawamura, Katsunori Ikoma, Kazuki Yoshida, Yuji Inagaki, Keita Ogawa, Shinya Sakai

  Brain Injury 28 (11) 1455 - 1460 0269-9052 2014 [Refereed][Not invited]
   

  Primary objective: To examine active inhibition of irrelevant stimuli and evaluate its neural basis using functional near infrared spectroscopy in patients with attention deficits after traumatic brain injury (TBI). Research design: Case control study. Methods and procedures: Ten patients with TBI and 10 healthy control subjects participated in this study. The Paced Auditory Serial Addition Test (PASAT) was performed with (distracting PASAT) and without (PASAT) distracting Japanese kana phonetic characters presented between each number. A block design was used. Subjects alternately performed each task three times. Main outcomes and results: Healthy controls performed better than patients with TBI on both the tasks. When performing the PASAT, healthy controls showed significant activity in every region of interest except the right lateral prefrontal cortex (PFC), but patients with TBI showed significant activity only in the left anterior PFC and left lateral PFC. When performing the distracting PASAT, the right lateral PFC was active in healthy controls, but not in patients with TBI. Conclusion: These results confirm that patients with moderate-to-severe TBI were affected by distractors that influenced order processing. It is suggested that the working memory of patients with TBI was affected by distracting stimuli, whereas that of healthy individuals was not.
• The Flow State Scale for Occupational Tasks: Development, Reliability, and Validity

  Kazuki Yoshida, Kiyoshi Asakawa, Taro Yamauchi, Satoshi Sakuraba, Daisuke Sawamura, Yui Murakami, Shinya Sakai

  HONG KONG JOURNAL OF OCCUPATIONAL THERAPY 23 (2) 54 - 61 1569-1861 2013/12 [Refereed][Not invited]
   

  Objective/Background: The degree of a patient's absorption in tasks as a measure of rehabilitation effectiveness has yet to be studied. The objective of this study is to develop a scale that can measure a patient's flow state in a clinical situation such as occupational therapy (OT). Methods: The final 14 items were determined from the comprehensive assessment of item analysis results by a preliminary experiment. A total of 240 participants engaged in computer games that induced three psychological states: flow, anxiety, and boredom. After performing each task, participants completed our flow scale and the State-Trait Anxiety Inventory (STAI). The reliability was calculated using Cronbach's alpha coefficient. The validity was confirmed from three viewpoints, namely, the correlation coefficient with the STAI, the discrimination power of each psychological state, and the accuracy of factor structure. An occupational analysis of various activities was also conducted to confirm that the computer game task was representative of measurable activities. Results: Cronbach's alpha coefficient was .918. The total score of the scale was significantly negatively correlated with the total score of STAI (r = -.537, p < .01). A significant difference among each psychological state was observed (p < .01). Covariance structure analysis indicated that the model fit index showed an acceptable fit. The computer game task used in this experiment was closely related to games, crafts, learning, cooking, and playing an instrument. Conclusion: Our flow scale appears to have satisfactory reliability and validity to verify quantitatively whether the occupational tasks used in OT can effectively provide a flow experience for patients. Copyright (C) 2013, Elsevier (Singapore) Pte. Ltd. All rights reserved.

Conference Activities & Talks

• The effect of differences in interoception on performance in heart rate variability biofeedback: A pilot study  [Not invited]

  Ryuji Saito, Kazuki Yoshida, Daisuke Sawamura

  The 4th Japan-Taiwan-Korea Neurorehabilitation Conference  2024/03
• Metacognitive Impairment and Its Association with Self-Awareness in Patients with Traumatic Brain Injury  [Not invited]

  K Yoshida, D Sawamura, K Ogawa, T Mototani, K Ikoma, S Sakai

  7th European Congress of NeuroRehabilitation  2023/09
• Effects of heart rate variability biofeedback training on anxiety reduction and its brain activity: an EEG study  [Not invited]

  Ryuji Saito, Kazuki Yoshida, Daisuke Sawamura, Akihiro Watanabe, Yukina Tokikuni, Shinya Sakai

  7th European Congress of NeuroRehabilitation  2023/08
• Neural predictors of the person impression  [Not invited]

  Ayahito Ito, Ryuta Aoki, Akihiro Watanabe, Yukina Tokikuni, Kazuki Yoshida, Yui Murakami, Shunichi Ogawa, Daisuke Sawamura, Hiroyoshi Ogishima, Ryuichi Tamai, Shogo Kajimura, Mie Kito, Masanori Yamanaka, Keise Izuma

  第46回日本神経科学大会  2023/08
• 喫煙に対する明示的、暗黙的態度 －喫煙者、非喫煙者における態度の乖離と暗黙的態度の異なる特徴  [Not invited]

  吉田一生, 高欣悦, 澤村大輔, 齋藤隆司, 村上優衣, 矢野里香, 桜庭聡, 吉田晋, 境信哉

  第46回日本高次脳機能障害学会  2022/12
• 運転課題中のマインドワンダリングによる不注意状態の検出  [Not invited]

  吉田一生, 澤村大輔, 八木幹雄, 中嶋悠, 齊藤隆司, 山村奈央, 小笠原克彦, 境信哉

  第46回日本高次脳機能障害学会  2022/12
• スクロールする日本語黙読時における視線移動の特徴  [Not invited]

  前山昂弥, 澤村大輔, 吉田一生, 鈴木哲平, 小笠原克彦, 境信哉

  第46回日本高次脳機能障害学会  2022/12
• 心拍変動バイオフィードバック訓練による不安低減効果とその脳活動  [Not invited]

  齋藤隆司, 吉田一生, 澤村大輔, 時國幸奈, 渡邉陽裕, 段ビョウ文, 境信哉

  第46回日本高次脳機能障害学会  2022/12
• 外傷性脳損傷患者のメタ認知能力低下の特徴とself-awarenessとの関連  [Not invited]

  吉田一生, 澤村大輔, 小川圭太, 本谷卓郎, 生駒一憲, 境信哉

  第46回日本神経心理学会  2022/09
• Interfering Effect of Cross-modal Conflict During Working Memory Task: A Near-infrared Spectroscopy Study

  Cui J, Sawamura D, Tanabe Y, MiuraH, Sugi M, Yoshida K, SaitoR, Watanabe A, Tokikuni Y, Sakai S

  fNIRS 2021 Virtual Meeting  2021/10
• 顔の印象判断における若年者バイアス ―fMRIとdrift-diffusion modelによる検討―

  伊藤文人, 吉田一生, 川崎伊織, 境信哉

  第55回日本作業療法学会  2021/09
• Comparison of effectiveness between participant-led and facilitator-led preventive care programs in Japan

  Shan Yun, Risa Takashima, Kazuki Yoshida, Daisuke Sawamura, Shinya Sakai

  Global Healthcare  2021/09
• The role of the ventromedial prefrontal cortex in automatic formation of impression and reflected impression

  Ayahito Ito, Kazuki Yoshida, Kenta Takeda, Daisuke Sawamura, Yui Murakami, Ai Hasegawa, Shinya Sakai, Keise Izuma

  32nd International Congress of Psychology  2021/07
• Young-age bias in valuation of faces  [Not invited]

  Ayahito Ito, Kazuki Yoshida, Ryuta Aoki, Toshikatsu Fujii, Iori Kawasaki, Akiko Hayashi, Aya Ueno, Etsuro Mori, Shinya Sakai, Shunji Mugikura, Shoki Takahashi, Nobuhito Abe

  European Society for Cognitive and Affective Neuroscience 2021  2021/06
• 顔の選好判断におけるown-age biasの神経基盤 -機能的MRIとdrift-diffusion modelによる検討-  [Not invited]

  吉田一生, 伊藤文人

  第23回ヒト脳機能マッピング学会  2021/03
• 腹内側前頭前野における「他者からどう思われそうか」の表象過程

  伊藤文人, 吉田一生, 武田賢太, 澤村大輔, 村上優衣, 長谷川愛, 境信哉, 出馬圭世

  第22回日本ヒト脳機能マッピング学会  2020/08
• 非利き手における箸動作スキルの獲得および脳活動の経時的変化-無作為化比較試験による検討-

  澤村大輔, 吉田一生, 境信哉

  第11回 日本ニューロリハビリテーション学会学術集会  2020/05
• The role of the ventromedial prefrontal cortex in automatic formation of impression and reflected impression

  Ito A, Yoshida K, Takeda K, Sawamura D, Murakami Y, Hasegawa A, Sakai S, Izuma K

  第9回社会神経科学研究会（岡崎）  2019/11
• 認知症高齢者に対するエビデンスに基づく作業療法の実践と影響要因

  長谷川愛, 澤村大輔, 吉田一生, 髙島理沙, 村田和香

  第53回日本作業療法学会  2019/09
• The ventromedial prefrontal responses toward faces automatically represent belief about “being-liked”  [Not invited]

  Ito A, Yoshida K, Takeda K, Sawamura D, Murakami Y, Hasegawa A, Sakai S, Izuma K

  8th International Symposium on Biology of Decision Making, Paris, France  2018/05
• Acquiring chopstick dexterity with the non-dominant hand and changes in brain activity pattern.  [Not invited]

  Sawamura D, Suzuki Y, Asano M, Kimura M, Honke T, Iwase Y, Horimoto Y, Yoshida S, Yoshida K, Sakai S

  The 1st Asia-Pacific Occupational Therapy Symposium, Taoyuan  2017/10
• Effect of exposure to short-wavelength light on susceptibility to motion sickness  [Not invited]

  Kim K, Hirayama K, Yoshida K, Yano R, Abe M, Otsuki M, Sakuraba S, Sakai S

  Symposium of the Society for the Study of Human Biology & International Association of Physiological Anthropology, Loughborough  2017/09
• 自閉症傾向が顔の選好判断および脳活動に与える影響  [Not invited]

  村上優衣, 境 信哉, 武田賢太, 澤村大輔澤, 吉田一生, 廣瀬喬道, 池田千紗, 萬井太規, 山本 徹, 伊藤文人

  日本健康行動科学会第16回学術大会,札幌  2017/09
• 短波長光への暴露がMotion sicknessの感受性に及ぼす影響  [Not invited]

  金 京室, 平山和美, 吉田一生, 矢野理香, 阿部正之, 大槻美佳, 桜庭 聡, 境 信哉

  日本健康行動科学会第16回学術大会,札幌  2017/09
• Correlation between flow state and the effects of attention training: randomized controlled trial of patients with traumatic brain injury  [Not invited]

  Yoshida K, Ogawa K, Mototani T, Inagaki Y, Sawamura D, Ikoma K, Shinya S

  The 12th world congress on brain injury (New Orleans)  2017/03
• The effect of wearing a medical mask and sunglasses on perceiver’s impression.  [Not invited]

  Fujii T, Ito A, Jenkins R, Sanders J, Yoshida K, Murakami Y, Sakai S, Tanabe M

  31th International Congress of Psychology, Yokohama  2016/07
• Effects of exposure to blue light on susceptibility to motion sickness  [Not invited]

  Kim K, Hirayama K, Yano R, Otsuki M, Sakuraba S, Yoshida K, Murakami Y, Sakai S

  The 1st Asia-Oceanian Congress for NeuroRehabilitation,  2015/09
• Neurological basis of impaired associated with persistent deficits after TBI.  [Not invited]

  Sawamura D, Ikoma K, Sugimori H, Inagaki Y, Ogawa K, Yoshida K, Abiko K, Sakai S

  Organization for Human Brain Mapping  2015/06
• 短波長光がmotion sicknessに及ぼす影響  [Not invited]

  金京室, 平山和美, 矢野理香, 大槻美佳, 桜庭聡, 吉田一生, 村上優衣, 境信哉

  日本生理人類学会第72回大会  2015/05
• Flow時の脳活動：近赤外線分光法を用いた検討  [Not invited]

  吉田一生, 澤村大輔, 稲垣侑士, 小川圭太, 生駒一憲, 境信哉

  日本生理人類学会第72回大会  2015/05
• Brain activity during the flow experience: a functional near-infrared spectroscopy study  [Not invited]

  Yoshida K, Sawamura D, Inagaki Y, Ogawa K, Ikoma K, Sakai S

  16th International Congress of the World Federation of Occupational Therapists (Yokohama)  2014/06
• Flow experience during attentional training improves function: an exploratory case study two patients following traumatic brain injury.  [Not invited]

  Yoshida K, Sawamura D, Ogawa K, Ikoma K, Asakawa K, Yamauchi T, Sakai S

  9th Annual Brain Injury Rehabilitation Conference (San Diego)  2014/05
• Active inhibition for task-irrelevant sound in patients with attention deficits after traumatic brain injury: An fNIRS study  [Not invited]

  Sawamura D, Ikoma K, Yoshida K, Inagaki Y, Ogawa K, Sakai S

  30th International Congress of Clinical Neurophysiology (Berlin)  2014/03
• 性差と加齢がもたらす他者の顔に対する価値表象に関わる神経基盤への影響  [Not invited]

  伊藤文人, 藤井俊勝, 阿部修士, 川崎伊織, 林亜希子, 上野彩, 吉田一生, 境信哉, 麦倉俊司, 高橋昭喜, 森悦朗

  第16回日本ヒト脳機能マッピング学会（仙台）  2014/03
• 顔に対する無意識的な価値表象に関わる神経基盤．  [Not invited]

  伊藤文人, 阿部修士, 河地庸介, 川崎伊織, 上野彩, 吉田一生, 境信哉, 松江克彦, 藤井俊勝

  第3回社会神経科学研究会  2013/11
• Dissociable roles of the nucleus accumbens and the ventromedial prefrontal cortex in preference formation for consciously and subconsciously perceived targets.  [Not invited]

  Ito A, Abe N, Kawachi Y, Kawasaki I, Ueno A, Yoshida K, Sakai S, Matsue Y, Fujii T

  Beauty & Value,  2013/10
• Neural correlates of made-up face recognition.  [Not invited]

  Ueno A, Ito A, Kawasaki I, Kawauchi Y, Yoshida K, Murakami Y, Sakai S, Iijima T, Matsue Y, Fujii T

  International neuropsychological society  2013/07
• Gender differences in the patterns of vmPFC activity associated with preference judgments for faces.  [Not invited]

  Ito A, Fujii T, Abe N, Kawasaki I, Hayashi A, Ueno A, Yoshida K, Sakai S, Mugikura S, Takahashi S, Mori E

  International neuropsychological society  2013/07
• クリニカルクラークシップ（Clinical Clerkship:CC）導入に向けての意向調査  [Not invited]

  吉田一生, 清水麻衣子, 金子翔拓, 大川浩子, 坪田貞子

  第47回日本作業療法学会  2013/06
• 脊髄性筋委縮症1型児のコミュニケーション手段について－親へのアンケート調査より－  [Not invited]

  星有理香, 佐々木千穂, 境直子, 佐藤洋子, 吉田一生, 桜庭聡, 真木誠, 境信哉, 加藤光広

  第55回日本小児神経学会  2013/05
• 脊髄性筋委縮症（Ⅰ型）児のコミュニケーション発達に関する里程標の作成.  [Not invited]

  星有理香, 桜庭聡, 佐々木千穂, 吉田一生, 境直子, 加藤光広, 佐藤洋子, 真木誠, 境信哉

  第21回日本小児神経学会北海道地方会  2013/03
• 作業課題版Flow尺度の開発―信頼性と妥当性の検討―  [Not invited]

  吉田一生, 浅川希洋志, 山内太郎, 桜庭聡, 澤村大輔, 境信哉

  第46回日本作業療法学会  2012/06

MISC

• 腱移行術後のスイッチング障害に対し筋電バイオフィードバックが有用であった症例

  本谷 卓朗, 河村 太介, 小川 圭太, 吉田 一生, 稲垣 侑士, 角井 由佳, 吉田 奈美, 生駒 一憲, 松井 雄一郎, 岩崎 倫政  国立大学リハビリテーション療法士学術大会誌  38-  49  -51  2017/03
• 脊髄性筋萎縮症(I型)児のコミュニケーション発達に関する里程標の作成

  星 有理香, 桜庭 聡, 佐々木 千穂, 吉田 一生, 境 直子, 加藤 光広, 佐藤 洋子, 真木 誠, 境 信哉  脳と発達  46-  (2)  146  -146  2014/03  [Not refereed][Not invited]
  
• 脊髄性筋萎縮症1型児のコミュニケーション手段について 親へのアンケート調査より

  星 有理香, 佐々木 千穂, 境 直子, 佐藤 洋子, 吉田 一生, 桜庭 聡, 真木 誠, 境 信哉, 加藤 光広  脳と発達  45-  (Suppl.)  S303  -S303  2013/05  [Not refereed][Not invited]
  
• 作業課題版Flow尺度の開発 信頼性と妥当性の検討

  吉田 一生, 浅川 希洋志, 山内 太郎, 桜庭 聡, 境 信哉  日本作業療法学会抄録集  46回-  O0422  -O0422  2012/06  [Not refereed][Not invited]
  
• 化粧品使用による魅力度の増強に関連する脳活動の検討

  上野彩, 上野彩, 伊藤文人, 伊藤文人, 川崎伊織, 河地庸介, 吉田一生, 村上優衣, 境信哉, 飯島敏夫, 松江克彦, 藤井俊勝  日本ヒト脳機能マッピング学会プログラム・抄録集  14th-  2012

Awards & Honors

• 2015/09 第72回日本生理人類学会 優秀発表賞
   

  受賞者: Yoshida Kazuki

Research Grants & Projects

• 心拍変動バイオフィードバックが心理・認知機能と脳活動に与える影響

  日本学術振興会科学研究費補助金：基盤研究（C）

  Date (from‐to) : 2021/04 -2024/03 

  Author : 境信哉、澤村大輔、吉田一生
• 外傷性脳損傷患者のメタ認知を測定する行動課題の作成と臨床的有用性の検討

  日本学術振興会科学研究費補助金：基盤研究（C）

  Date (from‐to) : 2020/04 -2023/03 

  Author : 吉田一生
• シチズンサポートプロジェクトによる社会的孤立・孤独の一次予防

  国立研究開発法人 科学技術振興機構 社会技術研究開発センター：戦略的創造研究推進事業

  Date (from‐to) : 2022/10
• 瞑想が外傷性脳損傷患者の脳活動、認知機能に与える影響

  日本学術振興会：科学研究費助成金 若手研究B：

  Date (from‐to) : 2016/04 -2019/03 

  Author : 吉田一生
• 訓練課題への没頭が外傷性脳損傷患者の注意機能の改善に与える影響

  日本学術振興会：科学研究費助成金 若手研究B

  Date (from‐to) : 2014/04 -2016/03 

  Author : 吉田一生

Educational Activities

Teaching Experience