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Last Updated :2024/09/04

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Master

Affiliation (Master)

  • Faculty of Medicine　Pathological Science　Pathology

Affiliation (Master)

  • Faculty of Medicine　Pathological Science　Pathology

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Profile and Settings

Profile and Settings

  • Name (Japanese)

    Tanei

  • Name (Kana)

    Zen-ichi

  • Name

    202001004477340387

Achievement

Education

  • 2010/04 - 2015/03  The University of Tokyo  Graduate School of Medicine
  • 2002/04 - 2008/03  Hokkaido University  School of Medicine

Published Papers

  • Taichi Nomura, Masaaki Niino, Toshio Odani, Ryoji Naganuma, Itaru Amino, Yusei Miyazaki, Sachiko Akimoto, Zen-Ichi Tanei, Taichi Kimura, Naoya Minami, Seiji Kikuchi
    Internal medicine (Tokyo, Japan) 2024/08/28 
    Macrophage activation syndrome (MAS) involves an excessive amount of acute inflammatory responses to inflammatory cytokines, particularly interleukin-6 (IL-6). IL-6 is also strongly associated with the pathophysiology of certain neuroimmunological diseases. However, there have so far been few reports of MAS being accompanied by neuroimmunological diseases. We herein report two cases of MAS comorbid with myasthenia gravis or neuromyelitis optica spectrum disorders, IL-6 related neuroimmunological diseases. Standard immunosuppressive therapies could not stabilize the symptoms in our cases until antibodies against the IL-6 receptor were administered. This finding suggests that it is important to consider the underlying pathophysiology of MAS in relation to these neuroimmunological diseases when treating affected patients.
  • Tetsuhiro Yamakado, Zen-Ichi Tanei, Yuka Ishikawa, Taichi Kimura, Yusuke Ishida, Shinya Tanaka
    Pathology international 74 (8) 489 - 492 2024/08
  • Yoshitaka Yamaguchi, Ryosuke Sawaya, Natsuko Shichinohe, Zen-Ichi Tanei, Maeho Yamasaki, Fumiki Tomeoka, Minoru Ajiki, Tatsuro Takada, Toshiya Shinohara, Katsuyuki Asaoka
    Internal medicine (Tokyo, Japan) 2024/06/20 
    A 68-year-old Japanese man developed a fever, headache, hiccups, and altered consciousness. Brain magnetic resonance imaging (MRI) revealed a hemorrhagic lesion in the right temporal lobe and multiple high-intensity white matter lesions. A brain biopsy showed pathological findings consistent with acute disseminated encephalomyelitis (ADEM), suggesting a diagnosis of acute hemorrhagic leukoencephalitis (AHLE), an aggressive ADEM variant. The patient also developed myodesopsia and was diagnosed with retinal vasculitis, likely due to a hyperimmune state caused by AHLE. Corticosteroids enabled full recovery. Although AHLE is uncommon in elderly individuals, clinicians should be aware of its occurrence in this patient subgroup and recognize potential retinal manifestations associated with AHLE.
  • Sogo Oki, Yukitomo Ishi, Ryosuke Sawaya, Michinari Okamoto, Hiroaki Motegi, Zen-Ichi Tanei, Masumi Tsuda, Takashi Mori, Kentaro Nishioka, Hiromi Kanno-Okada, Hidefumi Aoyama, Shinya Tanaka, Shigeru Yamaguchi, Miki Fujimura
    Acta neurochirurgica 166 (1) 263 - 263 2024/06/12 
    BACKGROUND: With the recent advent of genetic testing, IDH-mutant glioma has been found among adult brainstem gliomas. However, the clinical outcome and prognosis of IDH-mutant brainstem gliomas in adults have not been elucidated. This study aimed to investigate the clinical outcome, radiological findings, and genetic features of adult patients with IDH-mutant diffuse brainstem gliomas. METHODS: Data from adult patients with brainstem glioma at Hokkaido University Hospital between 2006 and 2022 were retrospectively analyzed. Patient characteristics, treatment methods, genetic features, and prognosis were evaluated. RESULTS: Of 12 patients with brainstem glioma with proven histopathology, 4 were identified with IDH mutation. All patients underwent local radiotherapy with 54 Gray in 27 fractions combined with chemotherapy with temozolomide. Three patients had IDH1 R132H mutation and one had IDH2 R172G mutation. The median progression-free survival and overall survival were 68.4 months and 85.2 months, respectively, longer than that for IDH-wildtype gliomas (5.6 months and 12.0 months, respectively). At the time of initial onset, contrast-enhanced lesions were observed in two of the four cases in magnetic resonance imaging. CONCLUSION: As some adult brainstem gliomas have IDH mutations, and a clearly different prognosis from those with IDH-wildtype, biopsies are proactively considered to confirm the genotype.
  • Naoki Kosaka, Takanori Uchiyama, Masahiro Onozawa, Jun Nagai, Jiro Koya, Suguru Ishizaka, Toshiyuki Nagai, Yohei Ikebe, Kenjiro Kato, Zen-Ichi Tanei, Jun Sakakibara-Konishi, Yuta Hasegawa, Hiroyuki Ohigashi, Hideki Goto, Daigo Hashimoto, Hideki Ujiie, Satoshi Hirano, Satoshi Konno, Toshihisa Anzai, Koji Taniguchi, Shinya Tanaka, Takanori Teshima
    Internal medicine (Tokyo, Japan) 2024/04/16 
    We herein present a fatal case of constrictive pericarditis (CP) due to acute myelomonocytic leukemia (AMML) in a patient who initially complained of an acute onset of chest pain two days after COVID-19 vaccination. An autopsy revealed pericardial infiltration of leukemic cells. CP is rarely associated with leukemia and only 14 cases have been reported in the literature. The etiology of CP in previous reports included leukemic infiltration, graft-versus-host disease, drug-induced, post-radiation, autoimmune, and otherwise unidentified. This case indicates that leukemic infiltration can cause CP and that clinicians should include leukemia in the differential diagnosis of CP.
  • Elly Arizono, Zen-Ichi Tanei, Keiya Iijima, Yukio Kimura, Yoko Shigemoto, Hiroyuki Maki, Midori Kusama, Kumiko Murayama, Masaki Iwasaki, Takashi Saito, Yuko Saito, Kazuhiro Saito, Noriko Sato
    Epilepsy & behavior reports 26 100674 - 100674 2024 
    Mild malformation of cortical development with oligodendroglial hyperplasia (MOGHE) is a recently proposed epileptogenic entity that is difficult to detect on MRI. We present a case of MOGHE that was successfully detected on T1WI-chemical shift-selective saturation (CHESS) MRI. The clinical presentation, MRI including T1WI-CHESS, functional images, and pathology findings of a 14-year-old Japanese girl diagnosed with MOGHE are described. T1WI-CHESS revealed an abnormal high signal along the affected lesion, whereas the findings shown by the other MR sequences were less obvious; interictal fluorodeoxyglucose-positron emission tomography indicated slightly decreased accumulation in the lesion, and subtraction ictal single photon emission computed tomography co-registered to MRI showed an increased blood flow. Together these observations suggest that T1WI-CHESS may be a useful MR sequence for detecting the lesions in patients with MOGHE.
  • Makoto Saito, Akio Mori, Sayaka Kajikawa, Emi Yokoyama, Minoru Kanaya, Koh Izumiyama, Masanobu Morioka, Takeshi Kondo, Zen-Ichi Tanei, Ai Shimizu
    World journal of clinical cases 11 (27) 6424 - 6430 2023/09/26 
    BACKGROUND: Unlike the already established effect of Helicobacter pylori (H. pylori) eradication on gastric mucosa-associated lymphoid tissue (MALT) lymphoma, its therapeutic effect on primary gastric diffuse large B-cell lymphoma (DLBCL) is still unclear. AIM: To clarify the efficacy of H. pylori eradication treatment for primary gastric DLBCL. METHODS: We reported on 3 new cases, and added them to 3 previously reported cases. We analyzed the usefulness of H. pylori eradication treatment for gastric DLBCL for a total of 6 cases at our center. RESULTS: Of the 6 patients (27-90 years old, 3 males and 3 females), all 3 patients with single lesions (one transformed from MALT lymphoma) achieved complete remission (CR) after H. pylori eradication. Regarding the 2 newly reported cases, CR was maintained for more than 6 years with eradication treatment alone. In contrast, none of the 3 patients with 2 lesions achieved CR. In 1 newly reported case, endoscopic CR was achieved in one lesion, while stable disease was obtained in the other lesion. Two patients with progressive disease responded to standard chemotherapy ± radiation and remained in CR for more than 6 years. CONCLUSION: We believe it is worthwhile to attempt H. pylori eradication for elderly patients with primary gastric DLBCL in a single lesion with a small tumor burden.
  • Koki Ise, Zen-Ichi Tanei, Yoshitaka Oda, Satoshi Tanikawa, Hirokazu Sugino, Yusuke Ishida, Masumi Tsuda, Yuko Gotoda, Kunihiko Nishiwaki, Hiroyuki Yanai, Tadashi Hasegawa, Kazuo Nagashima, Shinya Tanaka
    International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2023/06/14 
    Uterine tumor resembling ovarian sex cord tumor (UTROSCT) is a rare tumor with low malignant potential that commonly occurs in middle age. Although more than 100 cases have been reported to date, myxoid morphology is not well documented. Here, we present a 75-yr-old woman with abnormal vaginal bleeding, with an 8-cm mass in the uterine corpus detected by irregular, high-intensity signaling on T2-weighted imaging. The uterine mass had a glistening mucinous appearance on gross examination. Microscopically, most of the tumor cells were floating in the myxoid stroma. The tumor cells formed clusters or nests with abundant cytoplasm, while some exhibited trabecular or rhabdoid appearances. Immunohistochemically, tumor cells were positive for pancytokeratin (AE1/AE3), α-smooth muscle actin, CD10, progesterone receptor, and some sex cord markers such as calretinin, inhibin, CD56, steroidogenic factor-1. Electron microscopy demonstrated epithelial and sex cord differentiation. This tumor was negative for JAZF1-JJAZ1 fusion gene that is frequently found in low-grade endometrial stromal sarcoma. Fusion genes related to UTROSCT, including NCOA2/3, were not detected by reverse transcription polymerase chain reaction. The present case suggests that UTROSCT should be included in the differential diagnosis of myxoid uterine tumors.
  • Tomoyasu Matsubara, Shigeo Murayama, Tadashi Tsukamoto, Terunori Sano, Masashi Mizutani, Zen-Ichi Tanei, Yuji Takahashi, Masaki Takao, Yuko Saito
    Journal of neurology 270 (10) 5090 - 5093 2023/05/29
  • Satoshi Tanikawa, Yuki Ebisu, Tomáš Sedlačík, Shingo Semba, Takayuki Nonoyama, Takayuki Kurokawa, Akira Hirota, Taiga Takahashi, Kazushi Yamaguchi, Masamichi Imajo, Hinako Kato, Takuya Nishimura, Zen-Ichi Tanei, Masumi Tsuda, Tomomi Nemoto, Jian Ping Gong, Shinya Tanaka
    Scientific reports 13 (1) 2233 - 2233 2023/02/14 
    Neural regeneration is extremely difficult to achieve. In traumatic brain injuries, the loss of brain parenchyma volume hinders neural regeneration. In this study, neuronal tissue engineering was performed by using electrically charged hydrogels composed of cationic and anionic monomers in a 1:1 ratio (C1A1 hydrogel), which served as an effective scaffold for the attachment of neural stem cells (NSCs). In the 3D environment of porous C1A1 hydrogels engineered by the cryogelation technique, NSCs differentiated into neuroglial cells. The C1A1 porous hydrogel was implanted into brain defects in a mouse traumatic damage model. The VEGF-immersed C1A1 porous hydrogel promoted host-derived vascular network formation together with the infiltration of macrophages/microglia and astrocytes into the gel. Furthermore, the stepwise transplantation of GFP-labeled NSCs supported differentiation towards glial and neuronal cells. Therefore, this two-step method for neural regeneration may become a new approach for therapeutic brain tissue reconstruction after brain damage in the future.
  • Takuma Kaibara, Eiji Kondo, Masatake Matsuoka, Koji Iwasaki, Tomohiro Onodera, Keita Sakamoto, Yoshitaka Oda, Zen-Ichi Tanei, Daisuke Momma, Shinya Tanaka, Norimasa Iwasaki
    Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 2023/01/09 
    BACKGROUND: Recently, various types of engineered autologous chondrocyte implantation (ACI) have been developed. Atelocollagen-associated ACI (A-ACI) is the only ACI procedure covered by Japanese Health Insurance since 2013. The indications of the A-ACI are traumatic cartilage defects and osteochondral dissecans (OCD) for knee joints. PURPOSE: To evaluate midterm clinical results after A-ACI for the treatment for full-thickness cartilage defects of the knee. METHODS: Thirteen consecutive patients who underwent A-ACI between 2014 and 2018 had been prospectively enrolled in this study. There were 11 men and 2 women with a mean age of 34 years at the time of surgery. The causes of the cartilage defect were trauma in 10 knees and OCD in 3 knees. The total number of lesions was 15, which were comprised of the medial femoral condyle in 5 knees, the lateral femoral condyle in 5 knees, and the femoral trochlea in 5 knees. The mean size of the lesion was 5.3 cm2. Each knee was clinically and radiologically evaluated preoperatively and postoperatively. RESULTS: The mean Lysholm score improved significantly from 74.0 points to 94.0 points (p = 0.008) and each subscale in Knee injury and Osteoarthritis Outcome Score improved significantly (p < 0.001) at the mean final follow-up period of 51 months (range, 36-84 months). The magnetic resonance observation of cartilage repair tissue 2.0 score at the mean follow-up of 38 months was significantly higher than that at 2 months postoperatively (p = 0.014). According to the International Cartilage Repair Society (ICRS) grading scale, 3 knees were graded as normal, 3 knees as nearly normal, and 1 knee as severely abnormal in second-look arthroscopic evaluation at a mean of 22 months (range, 8-41 months) after A-ACI. CONCLUSION: The present study showed a significant subjective and objective clinical improvement in the A-ACI for large cartilage defects of the knee at a mean follow-up of 51 months (range, 36-84 months).
  • Yuki Munekata, Saki Yamamoto, Shun Kato, Yutaro Kitagawa, Ken Enda, Nanase Okazaki, Satoshi Tanikawa, Zen-Ichi Tanei, Yohei Ikebe, Takahiro Osawa, Soichiro Takamiya, Hideki Ujiie, Masahiro Onozawa, Satoshi Hirano, Miki Fujimura, Shinya Tanaka
    Autopsy & case reports 13 e2023433  2023 
    We report a fatal subdural empyema caused by Campylobacter rectus in a 66-year-old female who developed acute onset of confusion, dysarthria, and paresis in her left extremities. A CT scan showed hypodensity in a crescentic formation with a mild mid-line shift. She had a bruise on her forehead caused by a fall several days before admission, which initially raised subdural hematoma (SDH) diagnosis, and a burr hole procedure was planned. However, her condition deteriorated on the admission night, and she died before dawn. An autopsy revealed that she had subdural empyema (SDE) caused by Campylobacter rectus and Slackia exigua. Both microorganisms are oral microorganisms that rarely cause extra-oral infection. In our case, head trauma caused a skull bone fracture, and sinus infection might have expanded to the subdural space causing SDE. CT/MRI findings were not typical for either SDH or SDE. Early recognition of subdural empyema and prompt initiation of treatment with antibiotics and surgical drainage is essential for cases of SDE. We present our case and a review of four reported cases.
  • Miu Sasaki, Miori Ebata, Zen-Ichi Tanei, Yoshitaka Oda, Akiko Hamauchi, Satoshi Tanikawa, Hirokazu Sugino, Yusuke Ishida, Takenori Abe, Nobutaka Arai, Kazuya Sako, Shinya Tanaka
    Pathology international 2022/10/06 
    Krabbe disease is a lysosomal storage disease caused by a deficiency of the galactocerebrosidase (GALC) enzyme, which leads to demyelination of the central and peripheral nervous systems. Almost all patients with Krabbe disease are infants, and this is the first report of adult-onset cases that describe pathological findings. Here, we present two autopsy cases: a 73-year-old female and a 2-year-old male. The adult-onset case developed symptoms in her late thirties and was diagnosed by the identification of GALC D528N and L634S mutations and by T2-weighted magnetic resonance imaging; she had increased signal in the white matter along the pyramidal tract to the bilateral precentral gyrus, as well as from the triangular part to the posterior horn of the lateral ventricle. Microscopically, Klüver-Barrera staining was pale in the white matter of the precentral gyrus and occipito-thalamic radiation, and a few globoid cells were observed. The GALC mutations that were identified in the present adult-onset case do not completely inactivate GALC enzyme activity, resulting in focal demyelination of the brain.
  • Atsuko Motoda, Tomoyasu Matsubara, Zen-ichi Tanei, Yasuhiro Sakashita, Mikihiro Yamazaki, Ito Kawakami, Renpei Sengoku, Tomio Arai, Hirofumi Maruyama, Yuko Saito, Shigeo Murayama
    NEUROPATHOLOGY 43 (2) 129 - 134 0919-6544 2022/08 
    Phrenic nerves (PNs) play an important role in respiration; however, very few morphological studies have assessed them. This study aimed to provide control reference values, including the density of large and small myelinated PN fibers, for future pathological studies. We assessed a total of nine nerves from eight cases among consecutive autopsy cases registered to the Brain Bank for Aging Research between 2018 and 2019 (five men and three women, mean age 77.0 +/- 7.0 years). The nerves were sampled distally, and their structures were analyzed using semi-thin sections stained with toluidine blue. The mean and standard deviation of the density of each myelinated fiber of the PN was 6908 +/- 1132 fibers/mm(2) (total myelinated fiber), 4095 +/- 586 fibers/mm(2) (large diameter myelinated fiber; diameter >= 7 mu m), and 2813 +/- 629 fibers/mm(2) (small diameter myelinated fiber; diameter <7 mu m). There was no correlation between myelinated fiber density and age. This study provides the density measurement of the human PN myelinated fiber, and these findings can be used as reference values for the PN in elderly individuals.
  • Makoto Saito, Hiroki Egami, Takashi Kato, Emi Yokoyama, Koh Izumiyama, Akio Mori, Masanobu Morioka, Takeshi Kondo, Zen-Ichi Tanei
    Molecular and clinical oncology 17 (2) 129 - 129 2022/08 
    Colorectal follicular lymphoma (FL) is rare. In addition, it is even rarer that colon cancer develops synchronously with colorectal lymphoma. The present study reports a case of sigmoid colon cancer that developed 6 months after endoscopic resection of rectal FL. A 71-year-old man with a history of developing mucosa-associated lymphoid tissue lymphoma in his stomach at age 48, right neck region at age 59 (the latter later modified as FL) and lung adenocarcinoma at age 60 now suffers from rectal FL. Endoscopic submucosal dissection (ESD) was performed at our hospital (Aiiku Hospital), and 6 months after the treatment, sigmoid colon cancer was confirmed by colonoscopy for the follow-up study. The patient was successfully curatively resected by ESD plus local resection and has survived without a recurrence for >3 years with no treatment. It was speculated that in the present case, cancer-related genes were changed as a carcinogenic mechanism due to decreased immune function associated with the onset of lymphoma.
  • Yukitomo Ishi, Shigeru Yamaguchi, Michinari Okamoto, Ryosuke Sawaya, Shogo Endo, Hiroaki Motegi, Shunsuke Terasaka, Zen-Ichi Tanei, Kanako C Hatanaka, Shinya Tanaka, Miki Fujimura
    Brain tumor pathology 39 (3) 162 - 170 2022/07 
    The aim of this study was to analyze the clinical and radiological characteristics of glioblastomas (GBMs) harboring a BRAF mutation. Sequencing analysis of BRAF, IDH1/2, and TERT promoters was performed on GBM samples of patients older than 15 years. The clinical, pathological, and radiological data of patients were retrospectively reviewed. Patients were classified into three groups according to their BRAF and IDH1/2 status: BRAF group, IDH group, and BRAF/IDH-wild-type (WT) group. Among 179 GBM cases, we identified nine cases with a BRAF mutation and nine with IDH mutation. The WT group had 161 cases. Age at onset in the BRAF group was significantly lower compared to the WT group and was similar to the IDH group. In cases with negative IDH1-R132H staining and age < 55 years, 15.2% were BRAF-mutant cases. Similar to the IDH group, overall survival of the BRAF group was significantly longer compared with the WT group. Among nine cases in the BRAF group, three cases had hemorrhagic onset and prior lesions were observed in two cases. In conclusion, age < 55 years, being IDH1-R132H negative, with hemorrhagic onset or the presence of prior lesions are factors that signal recommendation of BRAF analysis for adult GBM patients.
  • Masumi Tsuda, Runa Horio, Lei Wang, Tomoko Takenami, Jun Moriya, Jun Suzuka, Hirokazu Sugino, Zenichi Tanei, Mishie Tanino, Shinya Tanaka
    Scientific reports 12 (1) 1733 - 1733 2022/02/02 
    It is important to determine the activation status of Rac and Cdc42 in cancer tissues for the prediction of metastasis and patient prognosis. However, it has been impossible to detect their spatial activation on formalin-fixed paraffin embedded (FFPE) surgical specimens thus far. Here, we established a novel detection technique for activated Rac/Cdc42 in human colon cancer FFPE tissues by using a p21-activated kinase (PAK)-Rac binding domain (RBD) detection probe fused with glutathione S-transferase (GST), designated GST-PAK-RBD, and novel rapid-immunohistochemistry (R-IHC) systems using noncontact alterating-current electric field mixing, although there is a technical limitation in that it may not distinguish between Rac members and Cdc42. In 50 cases of colon cancer, various activation patterns of Rac/Cdc42 were observed, which were designated plasma membrane, cytoplasm, mixed pattern, and polarized distribution. The activity was striking in the invasive fronts of tumors and significantly correlated with tumor invasion properties evaluated by TNM classification. Of note, in tissue microarray (TMA) samples, 29 of 33 cases demonstrated higher Rac1/Cdc42 activity in the tumor area than the corresponding normal mucosa. In addition, positive correlations were detected between Rac/Cdc42 activity and clinicopathological factors such as venous and lymphatic vessel invasion. These results suggest that understanding Rac and Cdc42 activations in cancer tissues would be valuable as an option for molecular therapy as personalized medicine.
  • Yasuhiro Sakashita, Tomoyasu Matsubara, Tadayuki Takata, Zen-Ichi Tanei, Atsuko Motoda, Mikihiro Yamazaki, Ito Kawakami, Renpei Sengoku, Yuko Saito, Tomio Arai, Masahito Yamada, Shigeo Murayama
    Neuropathology : official journal of the Japanese Society of Neuropathology 41 (6) 476 - 483 2021/10/21 
    Accumulation of phosphorylated α-synuclein in the central and peripheral nervous systems is a histological hallmark of Lewy body disease (LBD), including Parkinson's disease (PD), dementia with Lewy bodies (DLB), and LB-related pure autonomic failure. The submandibular gland is employed as a biopsy site for detecting Lewy pathology; however, the incidence of Lewy pathology in this region in autopsy-proven LBD cases at all stages from an aged Japanese cohort remains unclear. To validate the utility of Lewy pathology of the submandibular gland as a diagnostic biomarker for LBD, we investigated the submandibular gland Lewy pathology in autopsied patients. To determine the specificity, we prospectively evaluated the submandibular gland in 64 consecutive autopsied patients. To determine the sensitivity, we retrospectively assessed the submandibular gland in 168 consecutive autopsied patients who had prodromal or clinical LBD. In the prospective study, Lewy pathology was found in 21 of 64 patients, and nine of those 21 patients had the submandibular gland Lewy pathology. No Lewy pathology was found in 43 patients without CNS Lewy pathology, giving a specificity of 100%. In the retrospective study, Lewy pathology of the submandibular gland was detected in 126 of 168 patients. The sensitivity was 89.1% in PD and 75.4% in DLB. The sensitivity increased with disease progression. These findings support the utility of the submandibular gland biopsy for the pathological diagnosis of LBD.
  • Atsuhiko Sugiyama, Hajime Yokota, Sonoko Misawa, Hiroki Mukai, Yukari Sekiguchi, Kyosuke Koide, Tomoki Suichi, Jun Matsushima, Takashi Kishimoto, Zen-Ichi Tanei, Yuko Saito, Shoichi Ito, Satoshi Kuwabara
    BMC neurology 21 (1) 239 - 239 2021/06/24 
    BACKGROUND: This study aimed to investigate the frequency and risk factors for cerebral artery stenosis and occlusion in patients with polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome. METHODS: We reviewed results of magnetic resonance angiography (MRA) or computed tomography angiography (CTA) in 61 patients with POEMS syndrome seen between 2010 and 2017. Stenosis or occlusion was assessed in the initial MRA/CTA. Multivariate analysis was used to identify risk factors for artery stenosis/occlusion. In an autopsy case, pathologic examination was conducted of the occluded middle cerebral arteries. RESULTS: Stenosis (> 50 %) or occlusion of the major cerebral arteries was found in 29 (47.5 %) patients on the initial MRA/CTA. The internal carotid artery was involved most frequently (32.8 %), followed by the anterior (21.3 %) and middle (16.4 %) cerebral arteries. The basilar (1.3 %) and vertebral (3.6 %) arteries were rarely affected. Cerebral infarction developed in eight (13.1 %) patients. The serum vascular endothelial growth factor (VEGF) level was an independent predictor for stenosis/occlusion (odds ratio, 1.228; 95 % confidence interval, 1.042-1.447; P = 0.014). An autopsy study showed occluded middle cerebral arteries by fibrous and myxomatous thickening of intima with splitting of the internal elastic lamina. Follow-up MRA in 23 patients showed improved, worsened, and unchanged stenosis in 20.7 %, 8.7 %, and 69.6 %, respectively. CONCLUSIONS: Cerebral large-vessel stenosis or occlusion is frequently seen in approximately half of patients with POEMS syndrome. Vasculopathy was related to serum VEGF levels and thereby disease activity. Assessment of cerebral vessels is recommended in these patients to improve management.
  • Umma Habiba, Hirokazu Sugino, Roumyana Yordanova, Koki Ise, Zen-Ichi Tanei, Yusuke Ishida, Satoshi Tanikawa, Shunsuke Terasaka, Ken-Ichi Sato, Yuuta Kamoshima, Masahiko Katoh, Motoo Nagane, Junji Shibahara, Masumi Tsuda, Shinya Tanaka
    Acta neuropathologica communications 9 (1) 95 - 95 2021/05/21 
    Oligodendrogliomas are defined by mutation in isocitrate dehydrogenase (NADP(+)) (IDH)1/2 genes and chromosome 1p/19q codeletion. World Health Organisation diagnosis endorses testing for 1p/19q codeletion to distinguish IDH mutant (Mut) oligodendrogliomas from astrocytomas because these gliomas require different treatments and they have different outcomes. Several methods have been used to identify 1p/19q status; however, these techniques are not routinely available and require substantial infrastructure investment. Two recent studies reported reduced immunostaining for trimethylation at lysine 27 on histone H3 (H3K27me3) in IDH Mut 1p/19q codeleted oligodendroglioma. However, the specificity of H3K27me3 immunostaining in this setting is controversial. Therefore, we developed an easy-to-implement immunohistochemical surrogate for IDH Mut glioma subclassification and evaluated a validated adult glioma cohort. We screened 145 adult glioma cases, consisting of 45 IDH Mut and 1p/19q codeleted oligodendrogliomas, 30 IDH Mut astrocytomas, 16 IDH wild-type (Wt) astrocytomas, and 54 IDH Wt glioblastomas (GBMs). We compared immunostaining with DNA sequencing and fluorescent in situ hybridization analysis and assessed differences in H3K27me3 staining between oligodendroglial and astrocytic lineages and between IDH1-R132H and non-canonical (non-R132H) IDH1/2 Mut oligodendroglioma. A loss of H3K27me3 was observed in 36/40 (90%) of IDH1-R132H Mut oligodendroglioma. In contrast, loss of H3K27me3 was never seen in IDH1-R132L or IDH2-mutated 1p/19q codeleted oligodendrogliomas. IDH Mut astrocytoma, IDH Wt astrocytoma and GBM showed preserved nuclear staining in 87%, 94%, and 91% of cases, respectively. A high recursive partitioning model predicted probability score (0.9835) indicated that the loss of H3K27me3 is frequent to IDH1-R132H Mut oligodendroglioma. Our results demonstrate H3K27me3 immunohistochemical evaluation to be a cost-effective and reliable method for defining 1p/19q codeletion along with IDH1-R132H and ATRX immunostaining, even in the absence of 1p/19q testing.
  • Naho Katono, Masumi Tsuda, Jun Suzuka, Yoshitaka Oda, Lei Wang, Zen-Ichi Tanei, Mishie Tanino, Takanobu Ohata, Eisuke Nagabuchi, Yusuke Ishida, Shunsuke Kimura, Toshihiko Iwanaga, Shinya Tanaka
    Annals of clinical and laboratory science 51 (2) 271 - 276 2021/03 
    Here we present the case of a 73-year-old male with rectal adenocarcinoma with heterotopic ossification (HO). Cancer-associated HO in the digestive system is rare. Thus, the precise mechanism and clinicopathological significance of HO have not yet been defined. To clarify the molecular mechanisms of HO, we analyzed the expression levels of signaling molecules related to epithelial-mesenchymal transition (EMT) that lead to ossification in the tumor cells discriminating the ossified area (HO-area) and non-ossified area (non-HO area). Expression levels of BMP4 were elevated in both areas, whereas BMP2 was specifically increased in the HO-area by qPCR. EMT-related molecules such as Snail and Slug were especially higher in the HO-area. By immunohistochemistry, the expression of Smad4, nuclear staining of β-catenin, and the phosphorylated form of GSK-3β were detectable in both areas, and GSK-3β was highly phosphorylated in the HO-area. The tumor growth rate was extremely high, with the Ki-67 labeling index at 90%. In the HO-area, osteoblasts with alkaline phosphatase expression were distributed surrounding the tumor cells. This is the first demonstration of the involvement of EMT in HO of colon cancer through BMP/SMAD and WNT/β-catenin signaling pathways, which are especially prominent in the HO-area leading to the osteogenic property.
  • Kentaro Umeda, Ito Kawakami, Kenji Ikeda, Zen-Ichi Tanei, Tomoyasu Matsubara, Shigeo Murayama, Yuki Murahashi, Kazuhiro Niizato, Kenichi Oshima, Shuji Iritani
    Neuropathology : official journal of the Japanese Society of Neuropathology 41 (2) 127 - 132 2021/01/20 
    Anorexia nervosa (AN) is a serious eating disorder characterized by self-starvation and extreme weight loss. It has the highest mortality rate among all psychiatric disorders. Recent research indicates that malnutrition in AN patients induces various kinds of functional brain damage, but the pathophysiology of AN remains unclear. We report here the neuropathological findings of a 31-year-old Japanese woman. At age 24, she had a fear of gaining weight and reduced her dietary intake; she had extremely low body weight associated with overeating then self-induced vomiting. She was clinically diagnosed as having AN and was admitted to a psychiatric hospital with severe depression and suicidal thoughts. At age 31, she died despite intensive physical care and psychotherapy. Neuropathological examination revealed increased capillary blood vessels and slight fibrillary gliosis in the mammillary bodies, with similarities to Wernicke encephalopathy. The brainstem exhibited the characteristic features of central pontine myelinolysis, characterized by a sharply demarcated region of myelin pallor and relative sparing of axons. Senile changes, including neurofibrillary tangles/senile plaques, were not significant. Severe fibrillary gliosis was prominent around periventricular regions, including the caudate nucleus and nucleus accumbens, which are associated with cognition, emotion, and emotional behaviors via the dopaminergic pathways. These findings indicate that prolonged malnutrition in AN patients may induce brain damage, leading to dysfunction of the reward-related dopaminergic pathways. Furthermore, they represent the first pathological evidence that dysfunction of the cortico-limbic-striatal circuitry is involved in the pathophysiology of psychiatric symptoms in AN patients.
  • Toko Funaki, Takeshi Ito, Zen-ichi Tanei, Akiteru Goto, Toshiro Niki, Daisuke Matsubara, Yoshinori Murakami
    Biochemical and Biophysical Research Communications 534 172 - 178 0006-291X 2021/01 
    Cell adhesion molecule 1 (CADM1), which mediates intercellular adhesion between epithelial cells, is shown to be highly expressed in small-cell lung cancer (SCLC) and to enhance tumorigenicity of SCLC cells in nude mice. Here, we investigated the molecular mechanism underlying the oncogenic role of CADM1 in SCLC. CADM1 promoted colony formation of SCLC cells in soft agar. Analysis of deletion and point mutants of the conserved protein-binding motifs in CADM1 revealed that the 4.1 protein-binding motif in the cytoplasmic domain is responsible for the promotion of colony formation. Among the actin-binding 4.1 proteins, 4.1R was the only protein whose localization to the plasma membrane is dependent on CADM1 expression in SCLC cells. Knockdown of 4.1R suppressed the colony formation enhanced by CADM1, suggesting that 4.1R is required for the oncogenic role of CADM1 in SCLC. In primary SCLC, CADM1 expression was correlated with membranous localization of 4.1R, as was observed in a SCLC cell line. Moreover, membranous co-localization of CADM1 and 4.1R was associated with more advanced tumor stage. These results suggest that the formation of CADM1-4.1R complex would promote malignant features of SCLC.
  • Tanei, Z.-I., Saito, Y., Ito, S., Matsubara, T., Motoda, A., Yamazaki, M., Sakashita, Y., Kawakami, I., Ikemura, M., Tanaka, S., Sengoku, R., Arai, T., Murayama, S.
    Acta Neuropathologica 141 (1) 25 - 37 0001-6322 2021/01 
    AbstractLewy body disease (LBD) is a spectrum of progressive neurodegenerative disorders characterized by the wide distribution of Lewy bodies and neurites in the central and peripheral nervous system (CNS, PNS). Clinical diagnoses include Parkinson’s disease (PD), dementia with Lewy bodies, or pure autonomic failure. All types of LBD are accompanied by non-motor symptoms (NMSs) including gastrointestinal dysfunctions such as constipation. Its relationship to Lewy body-related α-synucleinopathy (Lewy pathology) of the enteric nervous system (ENS) is attracting attention because it can precede the motor symptoms. To clarify the role of ENS Lewy pathology in disease progression, we performed a clinicopathological study using the Brain Bank for Aging Research in Japan. Five-hundred and eighteen cases were enrolled in the study. Lewy pathology of the CNS and PNS, including the lower esophagus as a representative of the ENS, was examined via autopsy findings. Results showed that one-third of older people (178 cases, 34%) exhibited Lewy pathology, of which 78 cases (43.8%) exhibited the pathology in the esophagus. In the esophageal wall, Auerbach’s plexus (41.6%) was most susceptible to the pathology, followed by the adventitia (33.1%) and Meissner’s plexus (14.6%). Lewy pathology of the esophagus was significantly associated with autonomic failures such as constipation (p < 0.0001) and among PNS regions, correlated the most with LBD progression (r = 0.95, p < 0.05). These findings suggest that the propagation of esophageal Lewy pathology is a predictive factor of LBD.
  • Midori Kusama, Noriko Sato, Zen-ichi Tanei, Yukio Kimura, Masaki Iwasaki, Masayuki Sasaki, Kenji Miyagi, Yuko Saito
    Neurology: Clinical Practice 11 (5) 10.1212/CPJ.0000000000000987 - 10.1212/CPJ.0000000000000987 2163-0402 2020/10/06 
    Focal cortical dysplasia (FCD) is a congenital developmental anomaly that is one of the leading causes of refractory epilepsy. MRI is an essential examination and T1WI, T2WI, and FLAIR images are commonly used MR sequences for delineating FCD.1 However, these MRI findings are often insufficiently clear. We experienced two FCD cases that were much better visualized by using T1WI with chemical shift selective (CHESS) than with T2WI and FLAIR images. CHESS is the most frequently used fat suppression pulse in clinical practice. We report two cases in which CHESS clearly demonstrated FCD, and compare the cases' pathology and MRI findings.
  • Atsuhiko Sugiyama, Noriko Sato, Yukio Kimura, Hiroyuki Fujii, Yoko Shigemoto, Fumio Suzuki, Zen-Ichi Tanei, Yuko Saito, Masayuki Sasaki, Yuji Takahashi, Hiroshi Matsuda, Satoshi Kuwabara
    Journal of the neurological sciences 416 117040 - 117040 2020/07/16 [Refereed][Not invited]
     
    Dentatorubral-pallidoluysian atrophy (DRPLA) is an autosomal dominant neurodegenerative disorder caused by a CAG nucleotide repeat expansion in atrophin 1. A previous report described cerebellar white matter lesions on magnetic resonance imaging (MRI) in elderly-onset DRPLA patients, but this finding has not been fully investigated in a total population of DRPLA patients, including juvenile or early-adult onset patients. Herein, we attempted to determine the frequency, distribution pattern, and features of the cerebellar white matter lesions in 30 consecutive DRPLA patients. We also assessed the relationships between the cerebellar white matter lesions and clinical parameters and other MRI findings. The cerebellar white matter lesions were found in 43% of the 30 DRPLA patients, and in 70% of the late adult-onset DRPLA patients. In approx. Two-thirds of the patients with cerebellar white matter lesions, the lesions were localized in the paravermal area (paravermal lesions). Multiple logistic regression analyses revealed that the Fazekas grade of 'cerebral' white matter lesions was independently associated with 'cerebellar' white matter lesions. In conclusion, cerebellar white matter lesions are one of the distinctive MRI features in DRPLA patients, especially in patients with older age at onset. Cerebellar white matter lesions, as well as cerebral white matter lesions, might originate from the disease process of DRPLA itself, and they often have a characteristic distribution of paravermal lesions.
  • Takuya Omura, Rie Motoyama, Yoshiaki Tamura, Keisuke Nonaka, Zen-Ichi Tanei, Kazuhiro Shigemoto, Aya Midori Tokumaru, Shigeo Murayama, Tomio Arai, Atsushi Araki
    Geriatrics & gerontology international 20 (5) 500 - 501 2020/05 [Refereed][Not invited]
  • Yutaka Fukumoto, Takeshi Miyama, Zen-Ichi Tanei, Yuko Saito, Yoshihide Ota
    Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry 40 (3) 285 - 290 2020/05 [Refereed][Not invited]
     
    AIM: Tongue bites frequently occur during seizures in epilepsy patients. We report two cases of cognitively impaired Lennox-Gastaut syndrome patients with reactive lesions on the tongues. CASE PRESENTATIONS: Case 1 was a 30-year-old man whose chief complaint was mouth pain. Local finding was a small bean-sized pedunculated mass on the tongue, histopathologically diagnosed as inflammatory fibrous hyperplasia. Case 2 was a 45-year-old man whose chief complaint was bleeding from the mouth. His clinical finding was blood loss anemia. Local finding was a 20-mm-diameter pedunculated mass on the tongue, histopathologically diagnosed as pyogenic granuloma. CONCLUSION: These mass lesions were believed to be reactive, caused by repetitive minor damage involving reparative fibrous tissue response. Therefore, the two cases may have involved reparative responses to mucosal injury incurred by accidental bites during epileptic seizures. Intellectual disability made medical treatment difficult and had allowed the massive lesions to form. It is necessary for cognitively impaired epilepsy patients to undergo regular dental examinations in order to get used to dental checks and to increase the number of intraoral observations in the context of close cooperation between dentists and epilepsy therapists.
  • H J Nakaoka, Z Tanei, T Hara, J S Weng, A Kanamori, T Hayashi, H Sato, A Orimo, K Otsuji, K Tada, T Morikawa, T Sasaki, M Fukayama, M Seiki, Y Murakami, T Sakamoto
    Oncogenesis 6 (5) e334  2017/05/15 [Refereed][Not invited]
     
    Fibroblasts are some of the major cells in tumour tissues that influence tumour progression and drug resistance. However, our understanding on fibroblast-mediated tumour malignancy remains incomplete. Munc18-1-interacting protein 3 (Mint3) is known as an activator of hypoxia-inducible factor-1 (HIF-1) even during normoxia in cancer cells, macrophages and fibroblasts. Although Mint3 promotes ATP production via glycolysis by activating HIF-1 in cancer cells and macrophages, the biological role of Mint3-mediated HIF-1 activation in fibroblasts remains unclear. To address this, we examined whether Mint3 in fibroblasts contributes to tumour growth. Mint3 depletion in mouse embryonic fibroblasts (MEFs) decreased tumour growth of co-injected human breast cancer cells, MDA-MB-231 and epidermoid carcinoma A431 cells in mice. In MEFs, Mint3 also promoted cancer cell proliferation in vitro in a cell-cell contact-dependent manner. Mint3-mediated cancer cell proliferation depended on HIF-1, and further gene expression analysis revealed that the cell adhesion molecule, L1 cell adhesion molecule (L1CAM), was induced by Mint3 and HIF-1 in fibroblasts. Mint3-mediated L1CAM expression in fibroblasts stimulated the ERK signalling pathway via integrin α5β1 in cancer cells, and promoted cancer cell proliferation in vitro and tumour growth. In cancer-associated fibroblasts (CAFs), knockdown of MT1-MMP, which promotes Mint3-mediated HIF-1 activation, or Mint3 decreased L1CAM expression. As MEFs, CAFs also promoted cancer cell proliferation in vitro, and tumour growth via Mint3 and L1CAM. In human breast cancer specimens, the number of fibroblasts expressing L1CAM, Mint3 and MT1-MMP was higher in cancer regions than in adjacent benign regions. In addition, more phospho-ERK1/2-positive cancer cells existed in the peripheral region surrounded by the stroma than in the central region of solid breast cancer nest. Thus, Mint3 in fibroblasts might be a good target for cancer therapy by regulating cancer cell-stromal cell communication.
  • Takeshi Ito, Daisuke Matsubara, Ichidai Tanaka, Kanae Makiya, Zen-Ichi Tanei, Yuki Kumagai, Shu-Jen Shiu, Hiroki J Nakaoka, Shumpei Ishikawa, Takayuki Isagawa, Teppei Morikawa, Aya Shinozaki-Ushiku, Yasushi Goto, Tomoyuki Nakano, Takehiro Tsuchiya, Hiroyoshi Tsubochi, Daisuke Komura, Hiroyuki Aburatani, Yoh Dobashi, Jun Nakajima, Shunsuke Endo, Masashi Fukayama, Yoshitaka Sekido, Toshiro Niki, Yoshinori Murakami
    Cancer science 107 (10) 1527 - 1538 2016/10 [Refereed][Not invited]
     
    YAP1, the main Hippo pathway effector, is a potent oncogene and is overexpressed in non-small-cell lung cancer (NSCLC); however, the YAP1 expression pattern in small-cell lung cancer (SCLC) has not yet been elucidated in detail. We report that the loss of YAP1 is a special feature of high-grade neuroendocrine lung tumors. A hierarchical cluster analysis of 15 high-grade neuroendocrine tumor cell lines containing 14 SCLC cell lines that depended on the genes of Hippo pathway molecules and neuroendocrine markers clearly classified these lines into two groups: the YAP1-negative and neuroendocrine marker-positive group (n = 11), and the YAP1-positive and neuroendocrine marker-negative group (n = 4). Among the 41 NSCLC cell lines examined, the loss of YAP1 was only observed in one cell line showing the strong expression of neuroendocrine markers. Immunostaining for YAP1, using the sections of 189 NSCLC, 41 SCLC, and 30 large cell neuroendocrine carcinoma (LCNEC) cases, revealed that the loss of YAP1 was common in SCLC (40/41, 98%) and LCNEC (18/30, 60%), but was rare in NSCLC (6/189, 3%). Among the SCLC and LCNEC cases tested, the loss of YAP1 correlated with the expression of neuroendocrine markers, and a survival analysis revealed that YAP1-negative cases were more chemosensitive than YAP1-positive cases. Chemosensitivity test for cisplatin using YAP1-positive/YAP1-negative SCLC cell lines also showed compatible results. YAP1-sh-mediated knockdown induced the neuroendocrine marker RAB3a, which suggested the possible involvement of YAP1 in the regulation of neuroendocrine differentiation. Thus, we showed that the loss of YAP1 has potential as a clinical marker for predicting neuroendocrine features and chemosensitivity.
  • Kaoru Yamamoto, Zen-Ichi Tanei, Tadafumi Hashimoto, Tomoko Wakabayashi, Hiroyuki Okuno, Yasushi Naka, Ofer Yizhar, Lief E Fenno, Masashi Fukayama, Haruhiko Bito, John R Cirrito, David M Holtzman, Karl Deisseroth, Takeshi Iwatsubo
    Cell reports 11 (6) 859 - 865 2015/05/12 [Refereed][Not invited]
     
    In vivo experimental evidence indicates that acute neuronal activation increases Aβ release from presynaptic terminals, whereas long-term effects of chronic synaptic activation on Aβ pathology remain unclear. To address this issue, we adopted optogenetics and transduced stabilized step-function opsin, a channelrhodopsin engineered to elicit a long-lasting neuronal hyperexcitability, into the hippocampal perforant pathway of APP transgenic mice. In vivo microdialysis revealed a ∼24% increase in the hippocampal interstitial fluid Aβ42 levels immediately after acute light activation. Five months of chronic optogenetic stimulation increased Aβ burden specifically in the projection area of the perforant pathway (i.e., outer molecular layer of the dentate gyrus) of the stimulated side by ∼2.5-fold compared with that in the contralateral side. Epileptic seizures were observed during the course of chronic stimulation, which might have partly contributed to the Aβ pathology. These findings implicate functional abnormalities of specific neuronal circuitry in Aβ pathology and Alzheimer disease.

MISC

  • 種井 善一, 小野寺 康博, 田中 伸哉  BRAIN and NERVE: 神経研究の進歩  76-  (6)  0773  -0780  2024/06
  • 網膜血管炎を伴った高齢発症の急性出血性白質脳炎の一例
    留岡 史樹, 山口 佳剛, 澤谷 亮佑, 七戸 夏子, 種井 善一, 安喰 稔, 高田 達郎, 篠原 敏也  臨床神経学  64-  (6)  432  -432  2024/06
  • 脳腫瘍の分子診断と治療2 バイオマテリアルを用いたグリオーマ幹細胞ニッシェの構築
    津田 真寿美, 王 磊, 小田 義崇, 種井 善一, 田中 伸哉  Brain Tumor Pathology  41-  (Suppl.)  101  -101  2024/05
  • ハムスター肺炎モデルを用いたSARS-CoV-2肺炎の病理組織学的解析(Histopathological analysis of hamster SARS-CoV-2 pneumonia model)
    小田 義崇, 津田 真寿美, 王 磊, 種井 善一, 福原 崇介, 佐藤 佳, 田中 伸哉  日本病理学会会誌  113-  (1)  301  -301  2024/02
  • 神経性食指不振症の病理解剖症例(Autopsy case report of anorexia nervosa)
    白井 裕介, 種井 善一, 川内 真, 松居 剛志, 小田 義崇, 津田 真寿美, 篠原 敏也, 太田 聡, 田中 伸哉  日本病理学会会誌  113-  (1)  344  -344  2024/02
  • 正中弓状靱帯症候群と膵頭部癌により致死的な十二指腸出血を来たした1剖検例(An autopsy case of fatal hemorrhage due to median arch ligament syndrome and pancreatic cancer)
    伊勢 昂生, 大塚 拓也, 濱 憲輝, 潟沼 朗生, 小田 義崇, 種井 善一, 津田 真寿美, 太田 聡, 篠原 敏也, 田中 伸哉  日本病理学会会誌  113-  (1)  398  -399  2024/02
  • 脊髄capillary hemangiomaの病理像(Pathology of the capillary hemangioma of the spinal cord)
    種井 善一, 小野 裕介, 小田 義崇, 津田 真寿美, 大竹 安史, 今村 博幸, 小柳 泉, 飛騨 一利, 水上 裕輔, 田中 伸哉  日本病理学会会誌  113-  (1)  436  -436  2024/02
  • マントルリンパ腫とびまん性大細胞型B細胞性リンパ腫のdiscordant lymphomaの一解剖例(An autopsy case of discordant lymphoma: mantle cell lymphoma and diffuse large B-cell lymphoma)
    岸浪 建, 小田 義崇, 王 磊, 江端 浩, 加藤 万里絵, 種井 善一, 津田 真寿美, 宮城島 拓人, 田中 伸哉  日本病理学会会誌  113-  (1)  453  -453  2024/02
  • 肺小細胞癌の治療中に白血球増多と線維素性心外膜炎を認めた一例
    山内 智仁, 種井 善一, 長井 淳, 小田 義崇, 菊池 遼, 小野澤 真弘, 津田 真寿美, 田中 敏, 豊島 崇徳, 田中 伸哉  日本病理学会会誌  113-  (1)  463  -463  2024/02
  • 慢性肺血栓塞栓症の二剖検例
    岸本 佳子, 種井 善一, 青木 健志, 棒田 浩基, 小田 義崇, 王 磊, 津田 真寿美, 田中 伸哉  日本病理学会会誌  113-  (1)  468  -468  2024/02
  • 14年後に再発したBRAF V600E変異を有するlow-grade gliomaの1例
    黒田 花音, 小田 義崇, 岡本 迪成, 村木 岳史, 種井 善一, 王 磊, 津田 真寿美, 高阪 真路, 西原 広史, 田中 伸哉  日本病理学会会誌  113-  (1)  482  -482  2024/02
  • 左同名半盲をきたした頭蓋内腫瘍の一例
    長野 七海, 種井 善一, 福島 大地, 小田 義崇, 王 磊, 津田 真寿美, 山村 明範, 田中 伸哉  日本病理学会会誌  113-  (1)  482  -482  2024/02
  • BRAF p.V600E変異を有するHigh-grade Gliomaの病理学的研究
    京野 里虹, 種井 善一, 伊師 雪友, 小田 義崇, 王 磊, 津田 真寿美, 佐藤 憲市, 寺坂 俊介, 田中 伸哉  日本病理学会会誌  113-  (1)  482  -482  2024/02
  • MELAS様症状とMT-ATP6 m.8639T>C変異を伴う71歳男性の一剖検例
    戸田 壮太郎, 小田 義崇, 種井 善一, 王 磊, 大森 優子, 石田 雄介, 津田 真寿美, 松岡 健, 田中 伸哉  日本病理学会会誌  113-  (1)  483  -483  2024/02
  • 30代男性のアミロイドアンギオパチーの病理像
    馬詰 知佐, 種井 善一, 小田 義崇, 藤井 恭子, 王 磊, 津田 真寿美, 山口 大志, 中村 博彦, 田中 伸哉  日本病理学会会誌  113-  (1)  483  -483  2024/02
  • FFPE検体の質量分析による交感神経節のレビー小体関連分子の探索
    宮本 裕也, 種井 善一, 小田 義崇, 王 磊, 津田 真寿美, 田中 伸哉  日本病理学会会誌  113-  (1)  483  -483  2024/02
  • Nerve sheath myxomaのプロテオミクス解析による免疫組織化学マーカー探索
    鍵谷 豪太, 種井 善一, 小田 義崇, 王 磊, 津田 真寿美, 飛騨 一利, 田中 伸哉  日本病理学会会誌  113-  (1)  483  -483  2024/02
  • CD10陽性のIgG型リンパ形質細胞性リンパ腫の1例
    金谷 穣, 種井 善一, 宮下 直樹, 一木 朝絵, 梶川 清芽, 横山 絵美, 泉山 康, 斎藤 誠, 森岡 正信, 盛 暁生, 関 真秀, 辻 隆裕, 大島 孝一, 小野澤 真弘, 田中 伸哉, 近藤 健  臨床血液  64-  (12)  1525  -1525  2023/12
  • SARS-CoV-2オミクロン株におけるハムスター肺炎モデルの病理組織学的解析
    小田 義崇, 津田 真寿美, 王 磊, 種井 善一, 福原 崇介, 佐藤 佳, 田中 伸哉  日本病理学会会誌  112-  (2)  132  -132  2023/10
  • 難治性てんかんの原因となった側頭葉Rosette-forming glioneuronal tumorの一例
    石田 裕樹, 原 敬二, 油川 陽子, 中原 岩平, 五嶋 大悟, 鷲見 佳泰, 種井 善一, 溝渕 雅広, 中村 博彦  てんかん研究  41-  (2)  330  -330  2023/09
  • 甲斐原 拓真, 近藤 英司, 濱崎 雅成, 鈴木 裕貴, 岩崎 浩司, 松岡 正剛, 小野寺 智洋, 種井 善一, 田中 伸哉, 岩崎 倫政  東日本整形災害外科学会雑誌  35-  (3)  361  -361  2023/08
  • アテロコラーゲンを用いた自家培養軟骨移植後に軟骨下骨嚢胞を生じた1例
    甲斐原 拓真, 近藤 英司, 濱崎 雅成, 鈴木 裕貴, 岩崎 浩司, 松岡 正剛, 小野寺 智洋, 種井 善一, 田中 伸哉, 岩崎 倫政  東日本整形災害外科学会雑誌  35-  (3)  361  -361  2023/08
  • 今月の症例 S状結腸にα-synuclein病理を確認した認知症を伴うパーキンソン病の1例
    穴田 麻眞子, 工藤 彰彦, 阿部 恵, 白井 慎一, 岩田 育子, 松島 理明, 矢口 裕章, 吉田 雅, 種井 善一, 矢部 一郎  日本内科学会雑誌  112-  (8)  1402  -1408  2023/08
  • てんかんを発症した72歳女性の右側頭葉内側部病変
    種井 善一, 浅野目 卓, 小野 裕介, 小田 義崇, 王 磊, 津田 真寿美, 佐藤 憲市, 水上 裕輔, 田中 伸哉  Brain Tumor Pathology  40-  (Suppl.)  126  -126  2023/05
  • 平塚 祐真, 佐藤 憲市, 浅野目 卓, 石渡 規生, 石田 裕樹, 杉尾 啓徳, 高梨 正美, 中村 博彦, 種井 善一, 田中 伸哉  脳神経外科ジャーナル  32-  (4)  246  -253  2023/04  
    Extraventricular neurocytoma(EVN)はまれな中枢神経原発腫瘍の1つである.本症例は27歳女性でトルコ鞍部に発生し,月経不順で発症した.下垂体腺腫が疑われ,内視鏡下経蝶形骨洞手術(eTSS)にて部分摘出が行われた.病理検査では乏突起膠腫に類似した蜂の巣構造がみられ,synaptophysinとNeuNが陽性であり,EVNと診断された.トルコ鞍部に発生したEVNは下垂体腺腫や頭蓋咽頭腫との鑑別が画像上困難であり,診断には病理検査が決定的となる.EVNは非常にまれな腫瘍であるがさまざまな部位に発生し得るため,神経細胞系の腫瘍が疑われた場合はEVNの可能性を検討する必要がある.(著者抄録)
  • 脳腫瘍に対する病理研究者としての克服戦略 ハイドロゲルによる髄膜腫幹細胞の探索(Strategies for overcoming the brain tumors presented by pathology researchers Search for meningioma stem cells using hydrogel)
    小田 義崇, 津田 真寿美, 湯澤 明夏, 王 磊, 鈴鹿 淳, ハビバ・ウンマ, 種井 善一, モーウリン・クリスチアン, グン 剣萍, 田中 伸哉  日本病理学会会誌  112-  (1)  184  -184  2023/03
  • 難病克服を目指す、ヒト死後脳研究の成果と未来 ブレインバンクから分かってきた高齢者のレビー病理
    種井 善一, 田中 伸哉  日本病理学会会誌  112-  (1)  208  -208  2023/03
  • TKIs耐性膠芽腫細胞の特性と耐性メカニズムの解析
    津田 真寿美, 王 磊, 小田 義崇, 谷川 聖, 種井 善一, 田中 伸哉  日本病理学会会誌  112-  (1)  278  -278  2023/03
  • ハイドロゲルを用いた中皮腫幹細胞の創出および治療標的分子の探索
    加藤 万里絵, 杉野 弘和, 津田 真寿美, 王 磊, 種井 善一, 小田 義崇, 谷川 聖, グン 剣萍, 田中 伸哉  日本病理学会会誌  112-  (1)  332  -332  2023/03
  • 72歳女性のMultinodular and Vacuolating Neuronal Tumor of the cerebrumの1例
    寺島 祐樹, 種井 善一, 浅野目 卓, 黒田 花音, 小田 義崇, 谷川 聖, 王 磊, 津田 真寿美, 佐藤 憲市, 田中 伸哉  日本病理学会会誌  112-  (1)  375  -375  2023/03
  • JCVとCMVの脳幹部重複感染症例におけるウイルスの局在解析
    黒田 花音, 種井 善一, 岡崎 ななせ, 工藤 彰彦, 阿部 恵, 寺島 祐樹, 谷川 聖, 津田 真寿美, 矢部 一郎, 田中 伸哉  日本病理学会会誌  112-  (1)  375  -375  2023/03
  • 慢性血栓塞栓性肺高血圧症の一剖検例
    岸本 佳子, 種井 善一, 青木 健志, 加藤 万里絵, 小田 義崇, 谷川 聖, 津田 真寿美, 田中 伸哉  日本病理学会会誌  112-  (1)  378  -378  2023/03
  • Becker型筋ジストロフィーの兄弟剖検症例の病理組織学的検討
    宮本 裕也, 種井 善一, 谷川 聖, 小田 義崇, 津田 真寿美, 加納 崇裕, 横田 卓, 矢部 一郎, 田中 伸哉  日本病理学会会誌  112-  (1)  378  -378  2023/03
  • 進行性核上性麻痺にTDP43 pathologyを合併した一剖検例
    鍵谷 豪太, 種井 善一, 谷川 聖, 小田 義崇, 王 磊, 津田 真寿美, 大槻 美佳, 田中 伸哉  日本病理学会会誌  112-  (1)  379  -379  2023/03
  • 電子顕微鏡的検討を行ったラブドイド髄膜腫の一症例
    戸田 壮太郎, 種井 善一, 京野 里虹, 寺島 祐樹, 谷川 聖, 小田 義崇, 王 磊, 津田 真寿美, 瀬尾 善宣, 田中 伸哉  日本病理学会会誌  112-  (1)  380  -380  2023/03
  • 拡張型心筋症を発症したEmery-Dreifuss型筋ジストロフィーの一剖検例
    佐々木 美羽, 種井 善一, 松島 理明, 石垣 隆弘, 桑原 健, 小田 義嵩, 谷川 聖, 津田 真寿美, 矢部 一郎, 田中 伸哉  日本病理学会会誌  112-  (1)  381  -381  2023/03
  • 髄膜腫の骨化におけるEpithelial-mesenchymal transitionの関与についての検討
    京野 里虹, 種井 善一, 寺島 祐樹, 小田 義崇, 谷川 聖, 王 磊, 津田 真寿美, 田中 伸哉  日本病理学会会誌  112-  (1)  381  -381  2023/03
  • FFPE検体の質量分析による肺小細胞癌の脳転移関連分子の解析
    江端 美織, 何 錦涛, 小田 義崇, 谷川 聖, 王 磊, 津田 真寿美, 種井 善一, 田中 伸哉  日本病理学会会誌  112-  (1)  383  -383  2023/03
  • 杉本 絢子, 辻野 一三, 中村 順一, 佐藤 隆博, 鈴木 雅, 高村 圭, 岩崎 沙理, 種井 善一, 谷口 浩二, 田中 伸哉, 今野 哲  日本呼吸器学会誌  12-  (増刊)  44  -44  2023/03
  • 【中枢神経系腫瘍の病理I】病理診断 コア グリア神経細胞および神経細胞性腫瘍
    種井 善一  病理と臨床  41-  (1)  0034  -0045  2023/01
  • 大槻美佳, 水戸泰紀, 橋爪明, 中川賀嗣, 谷川聖, 種井善一, 加藤万里絵, 田中伸哉, 田中伸哉  高次脳機能研究  43-  (1)  2023
  • 杉山淳比古, 佐藤典子, 木村有喜男, 岡本智子, 高橋祐二, 武田貴裕, 種井善一, 桑原聡  日本神経放射線学会プログラム・抄録集  52nd-  2023
  • 甲斐原拓真, 濱崎雅成, 鈴木裕貴, 松岡正剛, 小野寺智洋, 岩崎倫政, 近藤英司, 岩崎浩司, 小田義崇, 種井善一, 田中伸哉  北海道整形災害外科学会  142nd-  (142nd suppl)  5  -5  2023
  • 小島 圭祐, 岡田 耕平, 野津 麟太郎, 三木 康祐, 杉村 駿介, 日高 大輔, 小笠原 励起, 杉田 純一, 小笠原 正浩, 小林 直樹, 今村 雅寛, 加藤 万里絵, 種井 善一, 田中 伸哉, 太田 秀一  臨床血液  63-  (11)  1592  -1592  2022/11
  • SARS-CoV-2変異株を用いたハムスター肺炎モデルの病理組織学的解析
    小田 義崇, 津田 真寿美, 王 磊, 谷川 聖, 種井 善一, 佐藤 佳, 福原 崇介, 田中 伸哉  日本病理学会会誌  111-  (2)  113  -113  2022/10
  • ハイドロゲルを用いた髄膜腫がん幹細胞マーカーの検索(Identification of novel stemness marker of meningioma by using hydrogel)
    小田 義崇, 津田 真寿美, 湯澤 明夏, 王 磊, 谷川 聖, 種井 善一, グン 剣萍, 田中 伸哉  日本癌学会総会記事  81回-  P  -2111  2022/09
  • Psammomatous meningioma周囲に脳実質石灰化を認めた一例
    岡崎 ななせ, 谷川 聖, 種井 善一, 津田 真寿美, 大澤 崇宏, 松野 吉宏, 田中 伸哉  Brain Tumor Pathology  39-  (Suppl.)  124  -124  2022/05
  • 細胞外基質の電位変化に伴うJCウイルス増殖の制御
    谷川 聖, 野々山 貴行, 津田 真寿美, 王 磊, 種井 善一, Gong Jian Ping, 田中 伸哉  日本病理学会会誌  111-  (1)  263  -263  2022/03
  • 脊髄capillary hemangiomaの病理像
    種井 善一, 津田 真寿美, 小田 義崇, 谷川 聖, 杉野 弘和, 大竹 安史, 今村 博幸, 小柳 泉, 飛騨 一利, 田中 伸哉  日本病理学会会誌  111-  (1)  264  -264  2022/03
  • びまん性大細胞型B細胞性リンパ腫の化学療法中に突然死した1剖検例
    加藤 万里絵, 種井 善一, 小島 圭祐, 太田 秀一, ウンマ・ハビバ, 小田 義崇, 谷川 聖, 杉野 弘和, 津田 真寿美, 田中 伸哉  日本病理学会会誌  111-  (1)  308  -308  2022/03
  • 内頸動脈瘤術後に急激な意識障害をきたした神経線維腫症1型の一剖検例
    京野 里虹, 種井 善一, 岡崎 ななせ, 長内 俊也, 小田 義崇, 谷川 聖, 杉野 弘和, 津田 真寿美, 藤村 幹, 田中 伸哉  日本病理学会会誌  111-  (1)  356  -356  2022/03
  • SLEとGood症候群の治療経過中に脳幹障害を来たした一例
    黒田 花音, 種井 善一, 岡崎 ななせ, 工藤 彰彦, 阿部 恵, 小田 義崇, 谷川 聖, 杉野 弘和, 矢部 一郎, 田中 伸哉  日本病理学会会誌  111-  (1)  356  -356  2022/03
  • 甲状腺乳頭癌多発肺転移後に生じた拘束性換気障害の一剖検例
    鍵谷 豪太, 種井 善一, 若林 健人, 堀井 洋志, 小田 義崇, 谷川 聖, 杉野 弘和, 谷野 美智枝, 今野 哲, 田中 伸哉  日本病理学会会誌  111-  (1)  357  -357  2022/03
  • 細胞外基質の電位変化に伴うJCウイルス増殖の制御
    谷川 聖, 野々山 貴行, 津田 真寿美, 王 磊, 種井 善一, Gong Jian Ping, 田中 伸哉  日本病理学会会誌  111-  (1)  263  -263  2022/03
  • 脊髄capillary hemangiomaの病理像
    種井 善一, 津田 真寿美, 小田 義崇, 谷川 聖, 杉野 弘和, 大竹 安史, 今村 博幸, 小柳 泉, 飛騨 一利, 田中 伸哉  日本病理学会会誌  111-  (1)  264  -264  2022/03
  • びまん性大細胞型B細胞性リンパ腫の化学療法中に突然死した1剖検例
    加藤 万里絵, 種井 善一, 小島 圭祐, 太田 秀一, ウンマ・ハビバ, 小田 義崇, 谷川 聖, 杉野 弘和, 津田 真寿美, 田中 伸哉  日本病理学会会誌  111-  (1)  308  -308  2022/03
  • 内頸動脈瘤術後に急激な意識障害をきたした神経線維腫症1型の一剖検例
    京野 里虹, 種井 善一, 岡崎 ななせ, 長内 俊也, 小田 義崇, 谷川 聖, 杉野 弘和, 津田 真寿美, 藤村 幹, 田中 伸哉  日本病理学会会誌  111-  (1)  356  -356  2022/03
  • SLEとGood症候群の治療経過中に脳幹障害を来たした一例
    黒田 花音, 種井 善一, 岡崎 ななせ, 工藤 彰彦, 阿部 恵, 小田 義崇, 谷川 聖, 杉野 弘和, 矢部 一郎, 田中 伸哉  日本病理学会会誌  111-  (1)  356  -356  2022/03
  • 甲状腺乳頭癌多発肺転移後に生じた拘束性換気障害の一剖検例
    鍵谷 豪太, 種井 善一, 若林 健人, 堀井 洋志, 小田 義崇, 谷川 聖, 杉野 弘和, 谷野 美智枝, 今野 哲, 田中 伸哉  日本病理学会会誌  111-  (1)  357  -357  2022/03
  • 甲斐原拓真, 近藤英司, 濱崎雅成, 鈴木裕貴, 岩崎浩司, 松岡正剛, 小野寺智洋, 小田義崇, 種井善一, 田中伸哉, 岩崎倫政  整形外科バイオマテリアル研究会プログラム・抄録集  41st-  2022
  • ハイドロゲルを用いた新規髄膜腫治療標的分子の検討(Analysis of novel therapeutic target for meningioma using hydrogel)
    小田 義崇, 津田 真寿美, 湯澤 明夏, 王 磊, Umma Habiba, 杉野 弘和, 種井 善一, グン 剣萍, 田中 伸哉  日本病理学会会誌  110-  (2)  110  -110  2021/10
  • 【病理医が知っておくべき法令や指針】Q&A 剖検
    若狹 朋子, 木ノ元 直樹, 種井 善一, 金井 弥栄, 柴原 純二  病理と臨床  39-  (9)  904  -908  2021/09
  • 脊髄capillary hemangiomaの臨床病理学的特徴
    種井 善一, 津田 真寿美, 谷川 聖, 杉野 弘和, 石田 雄介, 大竹 安史, 今村 博幸, 小柳 泉, 飛騨 一利, 田中 伸哉  Brain Tumor Pathology  38-  (Suppl.)  119  -119  2021/05
  • 食道リン酸化αシヌクレインの臨床病理学的解析
    種井 善一, 齊藤 祐子, 伊藤 慎治, 松原 知康, 坂下 泰浩, 池村 雅子, 田中 伸哉, 仙石 錬平, 新井 冨生, 村山 繁雄  日本病理学会会誌  110-  (1)  226  -226  2021/03
  • 成人型Krabbe病の一剖検例
    佐々木 美羽, 江端 美織, 小田 義崇, 濱内 朗子, 谷川 聖, 種井 善一, 杉野 弘和, 石田 雄介, 佐光 一也, 田中 伸哉  日本病理学会会誌  110-  (1)  379  -379  2021/03
  • 脊髄炎の診断力向上を目指して 脊髄炎の病理像
    種井 善一  Japanese Journal of Diagnostic Imaging  39-  67  -67  2021/02
  • 澤谷亮佑, 伊師雪友, 山口秀, 岡本迪成, 茂木洋晃, 高宮宗一朗, 関俊隆, 大塚拓也, 若林健人, 松野吉宏, 種井善一, 田中伸哉, 藤村幹  日本脳腫瘍学会学術集会プログラム・抄録集  39th-  2021
  • 伊東剛, 舩城桐子, 種井善一, 仁木和郎, 松原大祐, 村上善則  日本がん転移学会学術集会・総会プログラム抄録集  30th-  2021
  • 城泰輔, 笹森徹, 種井善一, 越前谷行真, 矢野俊介, 飛騨一利, 齋藤久泰  日本脊髄外科学会プログラム・抄録集  36th (CD-ROM)-  2021
  • 高齢者におけるLimbic predominant TDP-43 proteinopathyとその合併病理に関する検討
    松原 知康, 内野 彰子, 山崎 幹大, 元田 敦子, 種井 善一, 河上 緒, 仙石 錬平, 齊藤 祐子, 村山 繁雄  臨床神経学  60-  (Suppl.)  S402  -S402  2020/11
  • 病理学的に嗅球欠損を認めた、パーキンソン病2症例の臨床病理学的検討
    齊藤 祐子, 松原 知康, 佐野 輝典, 水谷 真志, 種井 善一, 高橋 祐二, 村山 繁雄  臨床神経学  60-  (Suppl.)  S426  -S426  2020/11
  • 腎移植から27年後に発症した延髄原発リンパ増殖性疾患の一例
    島 かさ音, 種井 善一, 高原 実香, 村上 永尚, 山本 伸昭, 坂東 良美, 松原 知康, 村山 繁雄, 和泉 唯信  臨床神経学  60-  (5)  386  -386  2020/05
  • 水野 結花, 三浦 俊介, 遠山 聡, 尾松 淳, 宍戸 菜穂美, 山田 大資, 近藤 篤史, 種井 善一, 森川 鉄平, 佐藤 伸一  皮膚科の臨床  62-  (3)  361  -364  2020/03  [Not refereed][Not invited]
     
    ＜文献概要＞68歳,男性。糖尿病性腎症で透析中。頭部血管肉腫に対して放射線療法,化学療法,免疫療法,外科的切除を組み合わせた集学的治療を行うも,肺,肝臓,脾臓に多発転移が出現した。透析中に血圧低下と貧血の進行があり,またCTで血性腹水がみられた。放射線治療を計画したが治療前に再度急激な血圧低下と背部痛をきたし死亡した。病理解剖で,原発巣周囲の皮膚再発のほか,肝臓,肺,脾臓に血管肉腫の転移が確認された。脾転移の被膜破綻と1800mlの血性腹水を認め,出血性ショックが直接の死因と判明した。皮膚原発血管肉腫の脾転移はまれであるが,脾転移がある場合は脾破裂の可能性を念頭に置き治療する必要がある。
  • 褐色細胞腫を伴う下垂体腺腫に血管異常が合併した一剖検例
    高熊 将一朗, 小松 明子, 柿崎 元恒, 野中 敬介, 種井 善一, 村山 繁雄, 田中 知明, 河田 光弘, 井下 尚子, 新井 冨生  日本病理学会会誌  109-  (1)  368  -369  2020/03  [Not refereed][Not invited]
  • 伊東剛, 舩城桐子, 種井善一, 松原大祐, 松原大祐, 村上善則  日本がん転移学会学術集会・総会プログラム抄録集  29th-  2020
  • 亜急性の経過で著明な大脳白質病変の進行とmicrobleedsの増加を認め、脳生検で脳アミロイドアンギオパチーを伴う髄膜炎症所見を確認した76歳男性例
    織茂 賢太, 河合 三津保, 中嶋 秀樹, 岩田 信恵, 種井 善一, 村山 繁雄, 村井 弘之, 後藤 順  臨床神経学  60-  (1)  80  -80  2020/01  [Not refereed][Not invited]
  • ブレインバンク生前同意者への質的研究 家族性アルツハイマー病患者の語りの一例
    小幡 真希, 松原 知康, 種井 善一, 河上 緒, 渋川 茉莉, 本山 りえ, 広吉 祐子, 仙石 錬平, 仁科 裕史, 古田 光, 新井 冨生, 金丸 和富, 村山 繁雄  Dementia Japan  33-  (4)  577  -577  2019/10  [Not refereed][Not invited]
  • 死後脳研究ドナー登録者の意識 高齢者ブレインバンク生前同意登録者を対象とした質的研究
    小幡 真希, 松原 知康, 種井 善一, 渋川 茉莉, 本山 りえ, 広吉 祐子, 仙石 錬平, 仁科 裕史, 古田 光, 新井 冨生, 村山 繁雄  日本心理学会大会発表論文集  83回-  348  -348  2019/08  [Not refereed][Not invited]
  • 早期から幻覚、錐体路徴候を認めSNCA遺伝子のp.G51D変異を伴う家族性パーキンソン病の死亡時67歳女性剖検例
    宮崎 将行, 岡本 智子, 種井 善一, 佐野 輝典, 小松 奏子, 石浦 浩之, 三井 純, 辻 省次, 村山 繁雄, 長谷川 成人, 高橋 祐二, 齊藤 祐子  パーキンソン病・運動障害疾患コングレスプログラム・抄録集  13回-  105  -105  2019/07  [Not refereed][Not invited]
  • 高熊 将一朗, 柿崎 元恒, 野中 敬介, 松田 陽子, 種井 善一, 高梨 成彦, 村山 繁雄, 新井 冨生  日本病理学会会誌  108-  (1)  486  -486  2019/04  [Not refereed][Not invited]
  • 多発脳病変を認めたtumefactive MSの66歳女性例
    日野 理美, 川上 真吾, 鈴木 葉子, 前田 伸也, 山田 美菜子, 中瀬 浩史, 種井 善一, 村山 繁雄  臨床神経学  59-  (4)  221  -221  2019/04  [Not refereed][Not invited]
  • 肺高悪性度神経内分泌癌における細胞接着分子CADM1の発現と病理学的特徴
    種井 善一, 舩城 桐子, 伊東 剛, 松原 大祐, 深山 正久, 村上 善則  日本病理学会会誌  108-  (1)  352  -352  2019/04  [Not refereed][Not invited]
  • von Recklinghausen病に関連した消化管のGISTと食道の横紋筋増生を認めた1剖検例
    高熊 将一朗, 柿崎 元恒, 野中 敬介, 松田 陽子, 種井 善一, 高梨 成彦, 村山 繁雄, 新井 冨生  日本病理学会会誌  108-  (1)  486  -486  2019/04  [Not refereed][Not invited]
  • Zen-ichi Tanei, Masako Ikemura, Munetoshi Hinata, Ken-ichiro Sato, Atsushi Iwata, Masashi Fukayama, Shigeo Murayama  BRAIN PATHOLOGY  29-  104  -104  2019/02
  • 日野理美, 川上真吾, 鈴木葉子, 前田伸也, 山田美菜子, 中瀬浩史, 種井善一, 村山繁雄  臨床神経学(Web)  59-  (4)  2019
  • 「ブレインバンク」ドナー登録者の意識 アンケート調査のテキスト分析による研究
    小幡 真希, 畠山 幸子, 坂下 泰浩, 元田 淳子, 山崎 幹大, 渋川 茉莉, 種井 善一, 松原 知康, 本山 りえ, 広吉 祐子, 仙石 錬平, 加藤 貴行, 仁科 裕史, 金丸 和富, 古田 光, 新井 冨生, 村山 繁雄  Dementia Japan  32-  (3)  450  -450  2018/09  [Not refereed][Not invited]
  • がんの浸潤と転移、今までとこれから 細胞接着分子CADM1のがん浸潤、転移における役割(Cancer invasion and metastasis - A summary and the future Involvement of a cell adhesion molecule, CADM1, in cancer invasion and metastasis)
    村上 善則, 舩城 桐子, 坪井 裕見, 種井 善一, 松原 大祐, 大場 基, 伊東 剛  日本癌学会総会記事  77回-  85  -85  2018/09  [Not refereed][Not invited]
  • 乳癌間質中の線維芽細胞における低酸素応答活性化因子Mint3およびL1CAMの発現
    種井 善一, 中岡 寛樹, 尾辻 和尊, 多田 敬一郎, 森川 鉄平, 佐々木 毅, 坂本 毅治, 村上 善則, 深山 正久  日本病理学会会誌  106-  (1)  402  -402  2017/03  [Not refereed][Not invited]
  • 種井 善一, 高澤 豊, 三浦 泰朗, 齋藤 綾, 深山 正久  病理と臨床  30-  (9)  993  -1000  2012/09  [Not refereed][Not invited]
  • SOD1に新規の変異を認めた家族性筋萎縮性側索硬化症の1剖検例
    種井 善一, 池村 雅子, 黒飛 京子, 石川 俊平, 清水 潤, 村山 繁雄, 深山 正久  日本病理学会会誌  101-  (1)  299  -299  2012/03  [Not refereed][Not invited]
  • 名古 ゆり恵, 喜納 奈緒, 谷口 義実, 八杉 利治, 尾崎 喜一, 水谷 勝美, 種井 善一, 比島 恒和  東京産科婦人科学会会誌  60-  (2)  298  -304  2011/06  [Not refereed][Not invited]
     
    今回我々は、子宮体部原発と考えられた扁平上皮癌の1例を経験した。症例は73歳、6経妊3経産、閉経51歳。腹部違和感を主訴に前医受診し、画像検査で子宮体癌が疑われ当科紹介。子宮腟部・子宮頸管・子宮内膜の細胞診および組織診からは、いずれも扁平上皮癌が検出された。画像検査では子宮体癌および腹膜播種が疑われた。原発巣の確定を目的に、腹式単純子宮全摘術・両側付属器摘出術を施行。開腹時、大網播種および骨盤腹膜播種を認め、これらの播種巣は癌性癒着のため切除困難であり残存した。病理組織診断では、子宮体部の内膜上皮全体に扁平上皮癌の増殖を認め、一部で間質浸潤を認めた。子宮頸部と腟壁の一部にも上皮内扁平上皮癌を認めたが、明らかな間質浸潤を認めなかった。全体に占める腫瘍量の多さと内膜病巣でのみ間質浸潤を認めたこと、腹腔内進展様式より子宮体部原発扁平上皮癌と考えられた。術後補助化学療法としてPaclitaxel・Carboplatin併用療法を施行し、4コースまではPRの効果を得られていたが、5コース以降PDとなり、現在2nd line chemotherapyとしてIrinotecan単剤投与を行い、3コース投与時点でPRの効果が得られている。(著者抄録)
  • 比島 恒和, 堀口 慎一郎, 立石 陽子, 河合 繁雄, 加藤 生真, 山田 侑子, 松阪 恵介, 種井 善一, 藤原 崇, 門馬 久美子, 味澤 篤, 秋山 秀樹, 坂巻 壽, 根本 哲生, 船田 信顕  胃と腸  46-  (3)  229  -238  2011/03/25
  • 乳癌におけるductal featureもつ小葉癌とE-カドヘリン核陽性像との関連性についての解析検討
    堀口 慎一郎, 林 幸子, 小川 真澄, 山田 侑子, 種井 善一, 加藤 生真, 松坂 恵介, 立石 陽子, 河合 繁夫, 黒井 克昌, 船田 信顕, 比島 恒和  日本病理学会会誌  100-  (1)  308  -308  2011/03  [Not refereed][Not invited]
  • 先天性胆道拡張症術後40年経過して発生した腸型の管状腺腫を背景とする低異型度高分化腺癌の1例
    立石 陽子, 船田 信顕, 堀口 慎一郎, 加藤 生真, 松坂 恵介, 山田 侑子, 種井 善一, 河合 繁夫, 鶴田 耕二, 比島 恒和  日本病理学会会誌  100-  (1)  386  -386  2011/03  [Not refereed][Not invited]
  • メフロキン投与が有効であった進行性多巣性白質脳症の病理像
    種井 善一, 船田 信顕, 山田 侑子, 加藤 生真, 松坂 恵介, 立石 陽子, 河合 繁夫, 堀口 慎一郎, 深山 正久, 田中 こずえ, 岸田 修二, 比島 恒和  日本病理学会会誌  100-  (1)  395  -395  2011/03  [Not refereed][Not invited]
  • 恥骨に発生したperiosteal chondrosarcomaの1例
    加藤 生真, 河合 繁夫, 津田 祐輔, 山田 侑子, 種井 善一, 松坂 恵介, 立石 陽子, 堀口 慎一郎, 船田 信顕, 五嶋 孝博, 比島 恒和  日本病理学会会誌  100-  (1)  478  -478  2011/03  [Not refereed][Not invited]
  • 心筋梗塞後の細菌性心筋炎の一例
    種井 善一, 的場 智子, 腰山 博昭, 伊東 知子, 大久保 亮, 金澤 剛志, 北川 寛, 工藤 京平, 高谷 紗帆, 田中 諭, 東山 明日美, 帆士 縫, 山崎 和義, 横畠 絵美, 西原 広史, 長嶋 和郎, 田中 伸哉  日本病理学会会誌  95-  (1)  381  -381  2006/04

Association Memberships

  • 日本脳腫瘍病理学会   日本神経学会   日本臨床細胞学会   日本神経病理学会   日本病理学会   

Research Projects

  • 日本学術振興会：科学研究費助成事業 若手研究
    Date (from‐to) : 2021/04 -2024/03 
    Author : 種井 善一
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
    Date (from‐to) : 2016/04 -2019/03 
    Author : Tanei Zen-ichi
     
    High-grade neuroendocrine carcinoma of the lung, such as small cell carcinoma or large cell neuroendocrine carcinoma, is a cancer with a poor prognosis that causes lymph node metastases or distant metastases at an early pathological stage. Cell Adhesion Molecule 1 (CADM1) was identified as a tumor suppressor gene in non-small cell lung cancer, and its expression is decreased in advanced cancers of various organs. CADM1, however, serves as an oncogene in adult T-cell leukemia and therefore has conflicting functions. In this study, we clarified the possibility of CADM1 playing an oncogene in lung high-grade neuroendocrine cancer from clinicopathological analyses and experimental models.

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