Researcher Database

Hiroto Ogawa
Faculty of Science Biological Sciences Behavioral Neuroethology
Professor

Researcher Profile and Settings

Affiliation

  • Faculty of Science Biological Sciences Behavioral Neuroethology

Job Title

  • Professor

Degree

  • PhD(Okayama University)

URL

Research funding number

  • 70301463

J-Global ID

Profile

  • Field of specialization

    Neurobiology, Behavioral Neuroscience, Animal Physiology


    Research theme

    Study on the neural mechanism of sensory information processing and motor control in airflow-elicited escape behavior and phonotactic behavior of the cricket


    Education

    1992 PhD (Science) Graduate School of Natural Sciences, Okayama University


    Career

    1992 - 1995 Research Fellow, Fujitsu Laboratories Inc.

    1995 - 1997 Researcher, Kawachi Millibioflight Project, ERATO, Japan Science and Technology Agency

    1997 - 2008 Assistant Professor, Department of Biology, Saitama Medical School

    2002 - 2003 Visiting Research Assistant Professor, Montana State University, USA

    2008 - 2016 Associate Professor, Faculty of Science, Hokkaido University

    2009 - 2013 Researcher, 'Decoding and Controlling Brain Information', PRESTO, Japan Science and Technology Agency

    2016 - Professor, Faculty of Science, Hokkaido University


    Affiliation

    Society for Neuroscience, Japan Neurosciences Association, Japan Zoological Society, Japan Comparative Physiological and Biochemical Society, Japan Biophysical Society

Research Interests

  • 包括脳ネットワーク   脳情報の解読と制御   カルシウム感受性蛍光色素   共焦点レーザ走査型顕微鏡   連合学習   古典的条件付け   キノコ体   機械受容器   ポピュレーションコーディング   感覚情報処理   活動電位   光学計測   マルチサイトレコーディング   電位依存症カルシウムチャネル   backpropagating spike   FM1-43   神経可塑性   Oregon Green 488 BAPTA-1   光学測定   シナプス統合   dendritic spike   電位依存性カルシウムチャネル   樹状突起   神経細胞   昆虫   カルシウムイメージング   

Research Areas

  • Life sciences / Basic brain sciences / Optical imaging of brain actibity
  • Life sciences / Neuroscience - general / Neurobiology
  • Life sciences / Neuroscience - general / Neurobiology
  • Life sciences / Animals: biochemistry, physiology, behavioral science / Neuroethology

Academic & Professional Experience

  • 2016/04 - Today Hokkaido University Department of Biological Sciences, Faculty of Science Professor
  • 2009/10 - 2016/03 Hokkaido University Department of Biological Sciences, Faculty of Science Associate Professor
  • 2010/10 - 2013/03 Japan Science and Technology Agency PREST, Decoding and Controlling Brain Information Researcher
  • 1997/10 - 2009/09 Saitama Medical School Department of Biology Assistant professor
  • 2002/04 - 2003/03 Montana State University Center for Computational Biology Visiting Research Assistant Professor
  • 1995/02 - 1997/09 Japan Science and technology Agency ERATO Kawachi Millibioflight Project Researcher
  • 1992/04 - 1995/01 Fujitsu laboratories LTD Functional Organic Materials Laboratory Researcher

Education

  • 1989/04 - 1992/03  Okayama University  Graduate School of Natural Science
  • 1987/04 - 1989/03  Okayama University  Graduate School of Science
  • 1983/04 - 1987/03  Okayama University  Faculty of Science  Department of Biology

Association Memberships

  • The Japanese Society for Comparative Physiology and Biochemistry   THE BIOPHYSICAL SOCIETY OF JAPAN   THE ZOOLOGICAL SOCIETY OF JAPAN   THE JAPAN NEUROSCIENCE SOCIETY   Society for Neuroscience   

Research Activities

Published Papers

  • Nodoka Sato, Hisashi Shidara, Hiroto Ogawa
    Scientific reports 9 (1) 18112 - 18112 2019/12/02 [Refereed][Not invited]
     
    To survive a predator's attack successfully, animals choose appropriate actions from multiple escape responses. The motor performance of escape response governs successful survival, which implies that the action selection in escape behaviour is based on the trade-off between competing behavioural benefits. Thus, quantitative assessment of motor performance will shed light on the biological basis of decision-making. To explore the trade-off underlying the action selection, we focused on two distinct wind-elicited escape responses of crickets, running and jumping. We first hypothesized a trade-off between speed and directional accuracy. This hypothesis was rejected because crickets could control the escape direction in jumping as precisely as in running; further, jumping had advantages with regard to escape speed. Next, we assumed behavioural flexibility, including responsiveness to additional predator's attacks, as a benefit of running. The double stimulus experiment revealed that crickets running in the first response could respond more frequently to a second stimulus and control the movement direction more precisely compared to when they chose jumping for the first response. These data suggest that not only the motor performance but also the future adaptability of subsequent behaviours are considered as behavioural benefits, which may be used for choosing appropriate escape reactions.
  • Koki Makino, Noriyasu Ando, Hisashi Shidara, Naoto Hommaru, Ryohei Kanzaki, Hiroto Ogawa
    325 - 328 2019 [Refereed][Not invited]
  • Takuto Sakuma, Kazuya Nishi, Kaoru Kishimoto, Kazuya Nakagawa, Masayuki Karasuyama, Yuta Umezu, Shinsuke Kajioka, Shuhei J. Yamazaki, Koutarou D. Kimura, Sakiko Matsumoto, Ken Yoda, Matasaburo Fukutomi, Hisashi Shidara, Hiroto Ogawa, Ichiro Takeuchi
    ADVANCED ROBOTICS 33 (3-4) 134 - 152 0169-1864 2019 [Refereed][Not invited]
     
    Recent advances in robotics and measurement technologies have enabled biologists to record the trajectories created by animal movements. In this paper, we convert time series of animal trajectories into sequences of finite symbols, and then propose a machine learning method for gaining biological insight from the trajectory data in the form of symbol sequences. The proposed method is used for training a classifier which differentiates between the trajectories of two groups of animals such as male and female. The classifier is represented in the form of a sparse linear combination of subsequence patterns, and we call the classifier an S3P-classifier. The trained S3P-classifier is easy to interpret because each coefficient represents the specificity of the subsequence patterns in either of the two classes of animal trajectories. However, fitting an S3P-classifier is computationally challenging because the number of subsequence patterns is extremely large. The main technical contribution in this paper is the development of a novel algorithm for overcoming this computational difficulty by combining a sequential mining technique with a recently developed convex optimization technique called safe screening. We demonstrate the effectiveness of the proposed method by applying it to three animal trajectory data analysis tasks.
  • Iwatani Y, Ogawa H, Shidara H, Sakura M, Sato T, Hojo MK, Honma A, Tsurui K
    Advanced Robotics 33 (3-4) 183 - 194 2019/01 [Refereed][Not invited]
  • Someya M, Ogawa H
    Journal of Neurophysiology 120 (1) 139 - 148 0022-3077 2018/07 [Refereed][Not invited]
  • Nodoka Sato, Hisashi Shidara, Hiroto Ogawa
    JOURNAL OF INSECT PHYSIOLOGY 103 36 - 46 0022-1910 2017/11 [Refereed][Not invited]
     
    Arthropods including insects grow through several developmental stages by molting. The abrupt changes in their body size and morphology accompanying the molting are responsible for the developmental changes in behavior. While in holometabolous insects, larval behaviors are transformed into adult-specific behaviors with drastic changes in nervous system during the pupal stage, hemimetabolous insects preserve most innate behaviors whole life long, which allow us to trace the maturation process of preserved behaviors after the changes in body. Wind elicited escape behavior is one of these behaviors and mediated by cercal system, which is a mechanosensory organ equipped by all stages of nymph in orthopteran insects like crickets. However, the maturation process of the escape behavior after the molt is unclear. In this study, we examined time-series of changes in the wind elicited escape behavior just after the imaginal molt in the cricket. The locomotor activities are developed over the elapsed time, and matured 24 h after the molt. In contrast, a stimulus-angle dependency of moving direction was unchanged over time, meaning that the cercal sensory system detecting airflow direction was workable immediately after the molt, independent from the behavioral maturation. The post-molting development of the wind-elicited behavior was considered to result not simply from maturation of the exoskeleton or musculature because the escape response to heat-shock stimulus did not change after the molt. No effect of a temporal immobilization after the imaginal molt on the maturation of the wind-elicited behavior also implies that the maturation may be innately programmed without experience of locomotion.
  • Matasaburo Fukutomi, Hiroto Ogawa
    SCIENTIFIC REPORTS 7 (1) 15158  2045-2322 2017/11 [Refereed][Not invited]
     
    Acoustic signals trigger various behaviours in insects such as courtship or escape from predators. However, it remains unknown whether insects utilize acoustic signals to recognize environmental contexts. The cricket is a prominent model insect for neuroethological studies on acoustic behaviour because female crickets exhibit positive phonotaxis in response to male calling songs, and flying crickets display avoidance behaviour for high-frequency sounds such as echolocation call of bats. The carrier frequency of these sounds is a major factor in determining whether they initiate these acoustic behaviours. Here, we examined the impacts of different frequencies of tone sounds on cercal-mediated escape behaviour, using a 5-kHz tone corresponding to the calling song and a 15-kHz tone serving as a trigger of avoidance behaviours. Neither frequency elicited a response in the standing cricket by itself, but they had different impacts on walking responses to airflow stimuli. While the 15-kHz tone reduced response probability, extended moving distance, and enhanced turn-angle variability, the 5-kHz tone had no effect. Although both frequencies of tones facilitated walking backward, the 15-kHz tone had a larger effect than the 5-kHz tone. These frequency dependencies of behavioural modulation suggest that crickets can recognize acoustic contexts and alter their escape strategy accordingly.
  • Yoshichika Baba, Hiroto Ogawa
    The Cricket as a Model Organism: Development, Regeneration, and Behavior 211 - 228 2017/01/01 [Refereed][Not invited]
     
    In crickets, the cercal system is a mechanosensory system in which the receptor organ is a pair of antenna-like appendages called cerci located at the rear of the abdomen and covered with mechanosensory hairs, similar to the bristles on a bottlebrush. This system mediates the detection, localization, and identification of air currents surrounding the animal. Owing to the easy accessibility of the nervous system and advantages in physiological techniques, the cercal system of the cricket has been used as a model system for investigations of development, mechanoreceptor biomechanics, neural maps, and neural coding over the past few decades. In contrast, the behavioral significance of this system is still poorly understood. In early studies, the cercal system was regarded to be a simple system for triggering an escape reflex against an approaching predator. However, recent studies suggest that it is a more complex “generalist” system involved in various behaviors. In this chapter, we review studies on the cricket cercal system from a neuroethological point of view and discuss the future direction of neuroethological research on this system.
  • Matasaburo Fukutomi, Makoto Someya, Hiroto Ogawa
    JOURNAL OF EXPERIMENTAL BIOLOGY 218 (24) 3968 - 3977 0022-0949 2015/12 [Refereed][Not invited]
     
    Animals flexibly change their locomotion triggered by an identical stimulus depending on the environmental context and behavioral state. This indicates that additional sensory inputs in different modality from the stimulus triggering the escape response affect the neuronal circuit governing that behavior. However, how the spatio-temporal relationships between these two stimuli effect a behavioral change remains unknown. We studied this question, using crickets, which respond to a short air-puff by oriented walking activity mediated by the cercal sensory system. In addition, an acoustic stimulus, such as conspecific 'song' received by the tympanal organ, elicits a distinct oriented locomotion termed phonotaxis. In this study, we examined the cross-modal effects on wind-elicited walking when an acoustic stimulus was preceded by an air-puff and tested whether the auditory modulation depends on the coincidence of the direction of both stimuli. A preceding 10 kHz pure tone biased the wind-elicited walking in a backward direction and elevated a threshold of the wind-elicited response, whereas other movement parameters, including turn angle, reaction time, walking speed and distance were unaffected. The auditory modulations, however, did not depend on the coincidence of the stimulus directions. A preceding sound consistently altered the wind-elicited walking direction and response probability throughout the experimental sessions, meaning that the auditory modulation did not result from previous experience or associative learning. These results suggest that the cricket nervous system is able to integrate auditory and air-puff stimuli, and modulate the wind-elicited escape behavior depending on the acoustic context.
  • Hiroto Ogawa, Ruriko Mitani
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 467 (2) 185 - 190 0006-291X 2015/11 [Refereed][Not invited]
     
    The spatial dynamics of action potentials, including their propagation and the location of spike initiation zone (SIZ), are crucial for the computation of a single neuron. Compared with mammalian central neurons, the spike dynamics of invertebrate neurons remain relatively unknown. Thus, we examined the spike dynamics based on single spike-induced Ca2+ signals in the dendrites of cricket mechanosensory projection neurons, known as giant interneurons (GIs). The Ca2+ transients induced by a synaptically evoked single spike were larger than those induced by an antidromic spike, whereas subthreshold synaptic potentials caused no elevation of Ca2+. These results indicate that synaptic activity enhances the dendritic Ca2+ influx through voltage-gated Ca2+ channels. Stimulation of the presynaptic sensory afferents ipsilateral to the recording site evoked a dendritic spike with higher amplitude than contralateral stimulation, thereby suggesting that alteration of the spike waveform resulted in synaptic enhancement of the dendritic Ca2+ transients. The SIZ estimated from the spatial distribution of the difference in the Ca2+ amplitude was distributed throughout the right and left dendritic branches across the primary neurite connecting them in GIs. (C) 2015 Elsevier Inc. All rights reserved.
  • Hiroto Ogawa, Kotaro Oka
    JOURNAL OF NEUROSCIENCE 35 (33) 11644 - 11655 0270-6474 2015/08 [Refereed][Not invited]
     
    Stimulus-specific adaptation (SSA) is considered to be the neural underpinning of habituation to frequent stimuli and novelty detection. However, neither the cellular mechanism underlying SSA nor the link between SSA-like neuronal plasticity and behavioral modulation is well understood. The wind-detection system in crickets is one of the best models for investigating the neural basis of SSA. We found that crickets exhibit stimulus-direction-specific adaptation in wind-elicited avoidance behavior. Repetitive air currents inducing this behavioral adaptation reduced firings to the stimulus and the amplitude of excitatory synaptic potentials in wind-sensitive giant interneurons (GIs) related to the avoidance behavior. Injection of a Ca2+ chelator into GIs diminished both the attenuation of firings and the synaptic depression induced by the repetitive stimulation, suggesting that adaptation of GIs induced by this stimulation results in Ca2+-mediated modulation of postsynaptic responses, including postsynaptic short-term depression. Some types of GIs showed specific adaptation to the direction of repetitive stimuli, resulting in an alteration of their directional tuning curves. The types of GIs for which directional tuning was altered displayed heterogeneous direction selectivity in their Ca2+ dynamics that was restricted to a specific area of dendrites. In contrast, other types of GIs with constant directionality exhibited direction-independent global Ca2+ elevation throughout the dendritic arbor. These results suggest that depression induced by local Ca2+ accumulation at repetitively activated synapses of key neurons underlies direction-specific behavioral adaptation. This input-selective depression mediated by heterogeneous Ca2+ dynamics could confer the ability to detect novelty at the earliest stages of sensory processing in crickets.
  • Hiroto Ogawa, Yoriko Kajita
    NEUROSCIENCE LETTERS 584 282 - 286 0304-3940 2015/01 [Refereed][Not invited]
     
    Crickets (Gryllus bimaculatus) use the cercal sensory system at the rear of the abdomen to detect air currents and direct predator avoidance behavior. Sensory information regarding the direction and dynamic properties of air currents is processed within the terminal abdominal ganglion, and conveyed by ascending giant interneurons (GIs) to higher centers including the brain. However, the brain region responsible for decoding cercal sensory information has not yet been identified, nor the response properties within the brain characterized. In this study, we performed in vivo Ca2+ imaging to investigate wind-evoked neural activities within the cricket protocerebrum. Ca2+ responses to air current stimuli were observed at peripheral regions of the ventrolateral neuropile (VLNP) where projection of GIs' axon terminals has been observed in larvae. The wind-evoked Ca2+ response had temporal dynamics and directional sensitivity that varied with different recorded regions displaying transient or sustained Ca2+ increases. Individual cells showed Ca2+ elevation in response to air currents from a specific angle, while stimuli from a different angle evoked decreased signals. Removing the antennae reduced the air-current-evoked responses in VLNP, suggesting contribution of sensory inputs from antennae in addition to the cercal inputs. The VLNP is presumably an integrative center for mechanosensory processing from antennae and cerci where directional information is primarily decoded by protocerebral neurons. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
  • T. Shimoi, K. Mizutani, D. Kojima, Y. Kitamura, K. Hotta, H. Ogawa, K. Oka
    NEUROSCIENCE 268 149 - 158 0306-4522 2014/05 [Refereed][Not invited]
     
    We used FM imaging to identify neurons that receive sensory feedback from the body wall in a circuit for octopamine (OA)-evoked rhythmic locomotion in the earthworm, Eisenia fetida. We visualized synapses in which postsynaptic neurons receive the sensory feedback, by using FM1-43 dye to label the synapses of both motor and sensory pathways that are associated with locomotion, then clearing the motor pathway synapse labeling, and finally identifying the target synapses by distinguishing physiologically functional synapses through destaining using a high-K+ solution. A pair of synaptic regions associated with the sensory feedback was found to be located two or three cell body-widths away from the midline, between the anterior parts of the roots of the second lateral nerves (LNs) at the segmental ganglia (SGs). Using conventional intracellular recording and dye loading of the cell bodies surrounding these synaptic regions, we identified a pair of bilateral neurons with cell bodies larger than those of other cells in these regions, and named them "Oscillatory firing neurons Projecting to Peripheral nerves'' (OPPs). These had a bipolar shape and projected neurites to the ipsilateral first and third LNs, fired rhythmically, and had a burst timing synchronized with the motor pattern bursts from the ipsilateral first LNs. Current injection into an OPP caused firing in the ipsilateral first LNs, supporting the hypothesis that OPPs functionally project to the peripheral nerves. OPPs also sent neurites to the adjacent anterior and posterior SGs, suggesting connections with the adjacent segments. We conclude that FM imaging can be used to identify neurons involved in specific functions, and that OPPs are the first neurons to be associated with OA-induced locomotion in the earthworm. (C) 2014 IBRO. Published by Elsevier Ltd. All rights reserved.
  • Chihiro Sato Matsumoto, Hisashi Shidara, Koji Matsuda, Taro Nakamura, Taro Mito, Yukihisa Matsumoto, Kotaro Oka, Hiroto Ogawa
    JOURNAL OF INSECT PHYSIOLOGY 59 (12) 1235 - 1241 0022-1910 2013/12 [Refereed][Not invited]
     
    The cricket (Gryllus bimaculatus) is a hemimetabolous insect that is emerging as a model organism for the study of neural and molecular mechanisms of behavioral traits. However, research strategies have been limited by a lack of genetic manipulation techniques that target the nervous system of the cricket. The development of a new method for efficient gene delivery into cricket brains, using in vivo electroporation, is described here. Plasmid DNA, which contained an enhanced green fluorescent protein (eGFP) gene, under the control of a G. bimaculatus actin (Gb'-act) promoter, was injected into adult cricket brains. Injection was followed by electroporation at a sufficient voltage. Expression of eGFP was observed within the brain tissue. Localized gene expression, targeted to specific regions of the brain, was also achieved using a combination of local DNA injection and fine arrangement of the electroporation electrodes. Further studies using this technique will lead to a better understanding of the neural and molecular mechanisms that underlie cricket behaviors. (C) 2013 Elsevier Ltd. All rights reserved.
  • Momoko Oe, Hiroto Ogawa
    PLOS ONE 8 (11) e80184  1932-6203 2013/11 [Refereed][Not invited]
     
    Crickets exhibit oriented walking behavior in response to air-current stimuli. Because crickets move in the opposite direction from the stimulus source, this behavior is considered to represent 'escape behavior' from an approaching predator. However, details of the stimulus-angle-dependent control of locomotion during the immediate phase, and the neural basis underlying the directional motor control of this behavior remain unclear. In this study, we used a spherical-treadmill system to measure locomotory parameters including trajectory, turn angle and velocity during the immediate phase of responses to air-puff stimuli applied from various angles. Both walking direction and turn angle were correlated with stimulus angle, but their relationships followed different rules. A shorter stimulus also induced directionally-controlled walking, but reduced the yaw rotation in stimulus-angle-dependent turning. These results suggest that neural control of the turn angle requires different sensory information than that required for oriented walking. Hemi-severance of the ventral nerve cords containing descending axons from the cephalic to the prothoracic ganglion abolished stimulus-angle-dependent control, indicating that this control required descending signals from the brain. Furthermore, we selectively ablated identified ascending giant interneurons (GIs) in vivo to examine their functional roles in wind-elicited walking. Ablation of GI8-1 diminished control of the turn angle and decreased walking distance in the initial response. Meanwhile, GI9-1b ablation had no discernible effect on stimulus-angle-dependent control or walking distance, but delayed the reaction time. These results suggest that the ascending signals conveyed by GI8-1 are required for turn-angle control and maintenance of walking behavior, and that GI9-1b is responsible for rapid initiation of walking. It is possible that individual types of GIs separately supply the sensory signals required to control wind-elicited walking.
  • Kotaro Oka, Hiroto Ogawa
    Methods in Neuroethological Research 89 - 99 2013/01/01 [Refereed][Not invited]
     
    The earthworm is a suitable animal for investigating the relationships between its behavior and the function of its nervous system. However, this animal has not been widely used for neuroethological research because it is not a model organism. In this chapter, we describe the use of the earthworm as a plausible model for investigating locomotion activity and learning and memory abilities using several optical imaging techniques based on our previous studies. First, we demonstrate the usefulness of this animal briefl y, show its simple nervous system, and then focus on its locomotion mechanism in detail. Especially, we focus on experimental techniques using several fl uorescent dyes, e.g., FM1-43 for functional imaging of specific synapses and DAF for nitric oxide release from the ventral nervous system following different forms of stimulation. Finally, we conclude this chapter with a discussion on future studies of this animal with respect to learning and memory and imaging techniques.
  • Hiroto Ogawa, Zenji Kawakami, Tsuneo Yamaguchi
    JOURNAL OF INSECT PHYSIOLOGY 57 (10) 1358 - 1367 0022-1910 2011/10 [Refereed][Not invited]
     
    Two types of mechanosensitive proprioceptor organ are present on the stinging apparatus of the honeybee: campaniform sensilla and mechanosensory hairplates. The campaniform sensilla are located on the surface of the tapering sting-shaft, which comprises an unpaired stylet and paired lancets. Each sensillum on the lancet differs from that on the stylet in terms of their topography and external morphology. The sensory afferents of the campaniform sensilla display slow-adapted firing responses to deformation of the cuticle that would be caused by the action of inserting the sting into a substrate, and their afferent signals induce and/or prolong the stinging response. By contrast, the mechanosensory hairplates are located at basal cuticular plates and on the posterior surface of the lancet valves. Two fields of hairplates on the second ramus at the ventral edge of the groove and on the antero-lateral edge of the oblong plate respond synchronously to protraction of the lancet. During the stinging response, these hairplates are likely to detect any sliding movement of the lancet and its position relative to the stylet. Afferent signals produced by them are likely to provide important information to the neuronal circuit for the generation and modulation of the stinging motor pattern. (C) 2011 Elsevier Ltd. All rights reserved.
  • Hiroto Ogawa, Katsushi Kagaya, Mitsuo Saito, Tsuneo Yamaguchi
    JOURNAL OF INSECT PHYSIOLOGY 57 (2) 326 - 338 0022-1910 2011/02 [Refereed][Not invited]
     
    In adult female crickets (Gryllus bimaculatus), rhythmic movements of ovipositor valves are produced by contractions of a set of ovipositor muscles that mediate egg-laying behavior. Recordings from implanted wire electrodes in the ovipositor muscles of freely moving crickets revealed sequential changes in the temporal pattern of motor activity that corresponded to shifts between behavioral steps: penetration of the ovipositor into a substrate, deposition of eggs, and withdrawal of the ovipositor from the substrate. We aimed in this study to illustrate the neuronal organization producing these motor patterns and the pattern-switching mechanism during the behavioral sequence. Firstly, we obtained intracellular recordings in tethered preparations, and identified 12 types of interneurons that were involved in the rhythmic activity of the ovipositor muscles. These interneurons fell into two classes: 'initiator interneurons' in which excitation preceded the rhythmic contractions of ovipositor muscles, and 'oscillator interneurons' in which the rhythmic oscillation and spike bursting occurred in sync with the oviposition motor rhythm. One of the oscillator interneurons exhibited different depolarization patterns in the penetration and deposition motor rhythms. It is likely that some of the oscillator interneurons are involved in producing different oviposition motor patterns. Secondly, we analyzed oviposition motor patterns when the mecahnosensory hairs located on the inside surface of the dorsal ovipositor valves were removed. In deafferented preparations, the sequential change from deposition to withdrawal did not occur. Therefore, the switching from deposition pattern to withdrawal pattern is signaled by the hair sensilla that detect the passage of an egg just before it is expelled. (C) 2010 Elsevier Ltd. All rights reserved.
  • Mamiko Suzuki, Tetsuya Kimura, Hiroto Ogawa, Kohji Hotta, Kotaro Oka
    PLoS ONE 6 (4) e18244  1932-6203 2011 [Refereed][Not invited]
     
    Squid can rapidly change the chromatic patterns on their body. The patterns are created by the expansion and retraction of chromatophores. The chromatophore consists of a central pigment-containing cell surrounded by radial muscles that are controlled by motor neurons located in the central nervous system (CNS). In this study we used semi-intact squid (Sepioteuthis lessoniana) displaying centrally controlled natural patterns to analyze spatial and temporal activities of chromatophores located on the dorsal mantle skin. We found that chromatophores oscillated with miniature expansions/retractions at various frequencies, even when the chromatic patterns appear macroscopically stable. The frequencies of this miniature oscillation differed between "feature" and "background" areas of chromatic patterns. Higher frequencies occurred in feature areas, whereas lower frequencies were detected in background areas. We also observed synchronization of the oscillation during chromatic pattern expression. The expansion size of chromatophores oscillating at high frequency correlated with the number of synchronized chromatophores but not the oscillation frequency. Miniature oscillations were not observed in denervated chromatophores. These results suggest that miniature oscillations of chromatophores are driven by motor neuronal activities in the CNS and that frequency and synchrony of this oscillation determine the chromatic pattern and the expansion size, respectively. © 2011 Suzuki et al.
  • Yoshichika Baba, Akira Tukada, Hiroto Ogawa
    ZOOLOGICAL SCIENCE 27 (6) 506 - 513 0289-0003 2010/06 [Refereed][Not invited]
     
    We studied age-related sexual dimorphism of the terminal abdominal ganglion in the cricket, Gryllus bimaculatus using osmium/ethyl-gallate staining and GABA immunohistochemistry. We determined that the volume of the terminal abdominal ganglion increases with increasing body size. The growth ratio between longitude and width in the terminal abdominal ganglion is the same in all nymph stages and sexes. However, the longitudinal growth of the male terminal abdominal ganglion ceases in the 8th instar and the adult stage. Therefore, in the adult stage, sexual dimorphism is observed in ganglion morphology. Additionally, sexual dimorphism is also observed in numbers of neuronal somata and GABA-like immunoreactive neurons in the terminal abdominal ganglion. At the beginning of the 8th instar, the number of somata is greater in female crickets than in males. GABA-like immunoreactive neurons, which were classified into eight clusters, increased between the 8th instar and adult in both sexes, but their numbers were sexually dimorphic in the 7th and 8th instars, and in the adult. Females had a greater number of GABA-like immunoreactive neurons than males. These differences occurred mainly in the 8th neuromere cluster, as well as the anterior region of the 9-11th neuromeres.
  • Mamiko Suzuki, Tetsuya Kimura, Hiroto Ogawa, Kohji Hotta, Kotaro Oka
    INVERTEBRATE NEUROSCIENCE 9 (3-4) 185 - 193 1354-2516 2009/12 [Refereed][Not invited]
     
    To examine chromatophore control by FMRFamide-related peptide (FaRP), we investigated the pharmacological effect of FMRFamide on the chromatophores and the FMRFamide-immunoreactivity of nerves surrounding the muscles in the coastal squid, Sepioteuthis lessoniana. Applications of FMRFamide elicited expansion of black chromatophores and retraction of yellow chromatophores in the adult squid. FMRFamide-immunoreactive terminals were distributed along black chromatophore muscles but were not observed around the yellow ones. This means that FMRFamide functions differently for each of the two types of chromatophores in the adult squid. Moreover, the pharmacological effect of FMRFamide on the black chromatophores differed between adults and hatchlings; application of FMRFamide retracted black chromatophores in hatchlings but not in adults. These results indicate that certain squid species have an FaRP system for controlling the chromatophores in their skin and that the system changes during development.
  • H. Aonuma, Y. Kitamura, K. Niwa, H. Ogawa, K. Oka
    NEUROSCIENCE 157 (4) 749 - 761 0306-4522 2008/12 [Refereed][Not invited]
     
    The distribution of potential nitric oxide (NO) donor neurons and NO-responsive target neurons was revealed in the terminal abdominal ganglion (TAG) of the cricket. The expression of nitric oxide synthase (NOS) in the nervous system was examined by Western blotting using universal nitric oxide synthase (uNOS) antibody that gave about a 130 kDa protein band. Immunohistochemistry using the uNOS antibody detected neurons whose cell bodies are located at the lateral region of the TAG. These neurons expanded their neuronal branches into the dorsal-median region or the dorsal-lateral region of the TAG. NADPH-diaphorase histochemistry was performed to confirm the distribution of NOS-containing neurons. The distributions of cell bodies and stained neuronal branches were similar to those revealed by uNOS immunohistochemistry. NO-induced cGMP immunohistochemistry was performed to reveal NO-responsive target neurons. Most of the cell bodies stained by immunohistochemistry appeared at the dorsal side of the TAG. At the dorsal-median region, some unpaired neuronal cell bodies were strongly stained. Some efferent neurons whose axon innervate into each nerve root were strongly stained. The generation of NO in the TAG was detected by NO electrode. We found that NO is generally produced to maintain a basal concentration of 70 nM. Hemoglobin scavenged released NO from the ganglion. The concentration of NO was partly recovered when hemoglobin was replaced by normal saline. Application of 10 mu M L-arginine that is a substrate of NOS increased NO release by approximately 10 nM. Furthermore, an excitatory neurotransmitter acetylcholine (ACh) also increased NO generation by approximately 40-50 nM in concentration in addition to the basal level of 70 nM. Optical imaging with fluorescent NO-indicator demonstrated that ACh-induced enhancement of NO release was transiently observed in the outer-edge region of TAG, where cell bodies of NOS-immunoreactive neurons were located. These results suggest that ACh accelerates NO production via neuronal events activated by ACh in the TAG. (C) 2008 IBRO. Published by Elsevier Ltd. All rights reserved.
  • Hiroto Ogawa, Graham I. Cummins, Gwen A. Jacobs, Kotaro Oka
    JOURNAL OF NEUROSCIENCE 28 (18) 4592 - 4603 0270-6474 2008/04 [Refereed][Not invited]
     
    While sensory information is encoded by firing patterns of individual sensory neurons, it is also represented by spatiotemporal patterns of activity in populations of the neurons. Postsynaptic interneurons decode the population response and extract specific sensory information. This extraction of information represented by presynaptic activities is a process critical to defining the input - output function of postsynaptic neuron. To understand the "algorithm" for the extraction, we examined directional sensitivities of presynaptic and postsynaptic Ca2+ responses in dendrites of two types of wind-sensitive interneurons (INs) with different dendritic geometries in the cricket cercal sensory system. In IN 10-3, whose dendrites arborize with various electrotonic distances to the spike-initiating zone (SIZ), the directional sensitivity of dendritic Ca2+ responses corresponded to those indicated by Ca2+ signals in presynaptic afferents arborizing on that dendrite. The directional tuning properties of individual dendrites varied from each other, and the directional sensitivity of the nearest dendrite to the SIZ dominates the tuning properties of the spiking response. In IN 10-2 with dendrites isometric to the SIZ, directional tuning properties of different dendrites were similar to each other, and each response property could be explained by the directional profile of the spatial overlap between that dendrite and Ca2+-elevated presynaptic terminals. For IN 10-2, the directional sensitivities extracted by the different dendritic-branches would contribute equally to the overall tuning. It is possible that the differences in the distribution of synaptic weights because of the dendritic geometry are related to the algorithm for extraction of sensory information in the postsynaptic interneurons.
  • Hiroto Ogawa, Yoshichika Baba, Yoshiichiro Kitamura, Yoshichiro Kitamura, Hitoshi Aonuma, Kotaro Oka
    COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY 148 (3) 348 - 348 1096-4959 2007/11 [Refereed][Not invited]
  • Kohei Homma, Yoshfichiro Kitamura, Hiroto Ogawa, Kotaro Oka
    JOURNAL OF NEUROSCIENCE RESEARCH 84 (2) 316 - 325 0360-4012 2006/08 [Refereed][Not invited]
     
    As a neurotransmitter and neuromodulator, serotonin (5-HT) influences neuronal outgrowth in the nervous systems of several species. In PC12 cells, 5-HT is known to have neuritogenic effects, although the signal transduction pathway responsible for these effects is not understood. In this study, we hypothesized that a 5-HT-induced increase in intracellular Ca2+, concentration ([Ca2+](i)) could be involved in mediating the effects of 5-HT Application of 5-HT to PC12 cells enhanced nerve growth factor (NGF)induced neurite outgrowth in a dose-dependent manner, and the sensitivity of this neuritogenic effect was increased in differentiated PC12 cells. In accordance, an increase in [Ca2+](i) was observed following application of 5-HT in differentiated PC12 cells. This increase was amplified by further NGF treatment. 5-HT-induced increases in [Ca2+](i) were inhibited by MIDL 72222, a selective 5-HT3 receptor antagonist, and nifedipine, an L-type calcium channel blocker, but not by ketanserin, a 5-HT2 receptor antagonist, or thapsigargin, a specific inhibitor of endoplasmic reticulum Ca2+-ATPase. These pharmacological tests indicated that 5-HT-induced increases in [Ca2+](i) are mediated by activation of voltage-gated calcium channels via 5-HT3 receptors and that 5-HT-induced increases in [Ca2+](i) are likely to be independent of activation of 5-HT2 receptors in PC12 cells. Furthermore, the neuritogenic effect of 5-HT was suppressed by MDL 72222, nifedipine, calmodulin (CaM) inhibitor, and calcineurin inhibitors. Taken together, our results indicate that 5-HT-induced increases in [Ca2+]i, which are mediated via 5-HT3 receptors and L-type calcium channels in PC12 cells, and subsequent activation of CaM and calcineurin enhance NGF-induced neurite outgrowth. (c) 2006 wiley-Liss, Inc.
  • H Ogawa, GI Cummins, GA Jacobs, JP Miller
    JOURNAL OF NEUROBIOLOGY 66 (3) 293 - 307 0022-3034 2006/02 [Refereed][Not invited]
     
    The cercal sensory system of the cricket mediates the detection and analysis of low velocity air currents in the animal's immediate environment, and is implemented around an internal representation of air current direction that demonstrates the essential features of a continuous neural map. Previous neurophysiological and anatomical studies have yielded predictions of the global spatio-temporal patterns of activity that should be evoked in the sensory afferent map by air current stimuli of different directions. We tested those predictions by direct visualization of ensemble afferent activity patterns using Ca2+-sensitive indicators. The AM ester of the fluorescent Ca2+ indicator (Oregon Green 488 BAPTA-1 AM) was injected under the sheath of a cercal sensory nerve containing all of the mechanosensory afferent axons from one cercus. Optical signals were recorded with a digital intensified CCD camera. Control experiments using direct electrical stimulation of stained and unstained nerves demonstrated that the observed Ca2+ signals within the terminal abdominal ganglion (TAG) were due to activation of the dye-loaded sensory afferent neurons. To visualize the spatial patterns of air-current-evoked ensemble activity, unidirectional air currents were applied repeatedly from eight different directions, and the optically recorded responses from each direction were averaged. The dispersion of the optical signals by the ganglion limited the spatial resolution with which these ensemble afferent activity patterns could be observed. However, resolution was adequate to demonstrate that different directional stimuli induced different spatial patterns of Ca2+ elevation in the terminal arbors of afferents within the TAG. These coarsely-resolved, optically-recorded patterns were consistent with the anatomy-based predictions. (C) 2005 Wiley Periodicals, Inc.
  • Takeshi Kubota, Yutaka Shindo, Kentaro Tokuno, Hirokazu Komatsu, Hiroto Ogawa, Susumu Kudo, Yoshiichiro Kitamura, Koji Suzuki, Kotaro Oka
    Biochimica et biophysica acta 1744 (1) 19 - 28 0006-3002 2005/05/15 [Refereed][Not invited]
     
    To determine the nature of intracellular Mg2+ stores and Mg2+ release mechanisms in differentiated PC12 cells, Mg2+ and Ca2+ mobilizations were measured simultaneously in living cells with KMG-104, a fluorescent Mg2+ indicator, and fura-2, respectively. Treatment with the mitochondrial uncoupler, carbonyl cyanide p-(trifluoromethoxy) phenylhydrazone (FCCP), increased both the intracellular Mg2+ concentration ([Mg2+]i) and the [Ca2+]i in these cells. Possible candidates as intracellular Mg2+ stores under these conditions include intracellular divalent cation binding sites, endoplasmic reticulum (ER), Mg-ATP and mitochondria. Given that no change in [Mg2+]i was induced by caffeine application, intracellular IP3 or Ca2+ liberated by photolysis, it appears that no Mg2+ release mechanism thus exists that is mediated via the action of Ca2+ on membrane-bound receptors in the ER or via the offloading of Mg2+ from binding sites as a result of the increased [Ca2+]i. FCCP treatment for 2 min did not alter the intracellular ATP content, indicating that Mg2+ was not released from Mg-ATP, at least in the first 2 min following exposure to FCCP. FCCP-induced [Mg2+]i increase was observed at mitochondria localized area, and vice versa. These results suggest that the mitochondria serve as the intracellular Mg2+ store in PC12 cell. Simultaneous measurements of [Ca2+]i and mitochondrial membrane potential, and also of [Ca2+]i and [Mg2+]i, revealed that the initial rise in [Mg2+]i followed that of mitochondrial depolarization for several seconds. These findings show that the source of Mg2+ in the FCCP-induced [Mg2+]i increase in PC12 cells is mitochondria, and that mitochondrial depolarization triggers the Mg2+ release.
  • T Kubota, Y Shindo, K Tokuno, H Komatsu, H Ogawa, S Kudo, Y Kitamura, K Suzuki, K Oka
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1744 (1) 19 - 28 0167-4889 2005/05 [Refereed][Not invited]
     
    To determine the nature of intracellular Mg2+ stores and Mg2+ release mechanisms in differentiated PC12 cells, Mg2+ and Ca2+ mobilizations were measured simultaneously in living cells with KMG-104, a fluorescent Mg2+ indicator, and fura-2, respectively. Treatment with the mitochondrial uncoupler, carbonyl cyanide p-(trifluoromethoxy) phenylhydrazone (FCCP), increased both the intracellular Mg2+ concentration ([Mg2+](i)) and the [Ca2+](i) in these cells. Possible candidates as intracellular Mg2+ stores under these conditions include intracellular divalent cation binding sites, endoplasmic reticulum (ER), Mg-ATP and mitochondria. Given that no change in [Mg2+](i) was induced by caffeine application, intracellular IP3 or Ca2+ liberated by photolysis, it appears that no Mg2+ release mechanism thus exists that is mediated via the action of Ca2+ on membrane-bound receptors in the ER or via the offloading of Mg2+ from binding sites as a result of the increased [Ca2+](i). FCCP treatment for 2 min did not alter the intracellular ATP content, indicating that Mg2+ was not released from Mg-ATP, at least in the first 2 min following exposure to FCCP. FCCP-induced [Mg2+](i) increase was observed at mitochondria localized area, and vice versa. These results suggest that the mitochondria serve as the intracellular Mg2+ store in PC12 cell. Simultaneous measurements of [Ca2+](i) and mitochondrial membrane potential, and also of [Ca2+](i) and [Mg2+](i), revealed that the initial rise in [Mg2+](i) followed that of mitochondrial depolarization for several seconds. These findings show that the source of Mg2+ in the FCCP-induced [Mg2+](i) increase in PC12 cells is mitochondria, and that mitochondrial depolarization triggers the Mg2+ release. (c) 2004 Elsevier B.V All rights reserved.
  • H Watanabe, T Takaya, T Shimoi, H Ogawa, Y Kitamura, K Oka
    NEUROBIOLOGY OF LEARNING AND MEMORY 83 (2) 151 - 157 1074-7427 2005/03 [Refereed][Not invited]
     
    We investigated the process of memory consolidation following classical conditioning of earthworms. Earthworms were conditioned in paired trials by a weak vibration as a conditioned stimulus (CS), and by light as an unconditioned stimulus (US). The occurrence of a shrinking response upon exposure to the CS increased steadily with the number of paired training trials. When the training procedure was changed by increasing the intertrial interval (ITI), it was found that only those worms trained with a 68 s ITI exhibited long-term memory retention for at least 24 h. The influence of mRNA synthesis inhibition by actinomycin-D or of protein synthesis by anisomycin on memory consolidation was also examined. Induction of the long-term memory was blocked when either of these two compounds was injected into the body cavity of the worm within 25 min of conditioning with the 68 s ITI. These results demonstrate that the long-term memory is dependent upon protein synthesis in response to the upregulation of new transcription messengers. (C) 2004 Elsevier Inc. All rights reserved.
  • Investigation of intracellular magnesium mobilization pathways I PC12 cells B simultaneous Mg-Ca fluorescent imaging.
    Kubota T, Shindo Y, Tokuno K, Komatsu H, Ogawa H, Kitamura Y, Suzuki K, Oka K
    Journal of the American College of Nutrition 6 23 (6) 742S - 4S 0731-5724 2004/12 [Refereed][Not invited]
  • H Ogawa, Y Baba, K Oka
    NEUROSCIENCE LETTERS 358 (3) 185 - 188 0304-3940 2004/04 [Refereed][Not invited]
     
    We examined directional sensitivities in the dendritic activity of the identified giant interneurons (GIs) in the cricket, using in vivo Ca2+ imaging during different directional air-current stimuli. Air current stimulus evoked action potential burst and quick Ca2+ increase in GI. The stimulus direction of the maximal Ca2+ responses corresponded to that of the maximal voltage response. However, the shapes of the directional tuning curves based on the Ca2+ responses for each dendritic branch were different from the overall tuning curve based on spike counts for the cell. Moreover, different dendritic branches displayed distinct directional sensitivity profiles to the air-current stimuli. We propose that postsynaptic activities will influence the local Ca2+ signals in the distal dendrites, and produce the difference in directional sensitivity of the dendritic Ca2+ response. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
  • K Mizutani, T Shimoi, H Ogawa, Y Kitamura, K Oka
    NEUROSCIENCE RESEARCH 48 (4) 457 - 462 0168-0102 2004/04 [Refereed][Not invited]
     
    Role of sensory feedback to motor pattern activity concerning locomotion in the earthworm, Eisenia fetida, was investigated. We have previously reported that bath application of octopamine induces fictive locomotion in the earthworm. In this study, we have examined the role of sensory feedback during fictive locomotion by analyzing electrical activities from the cut end and intact first lateral nerves of the ventral nerve cord (VNC). From the cut end recordings, motor activity associated with fictive locomotion was measured. A mixture of sensory and motor activities was measured from the intact first lateral nerve using en passant recordings, and sensory activity was separated by subtraction of the cut end recording (mainly motor activities) from the intact first lateral nerve recording. We estimated the effect of sensory feedback from the earthworm body wall by comparing recordings that made when the preparation was in-contact with a substrate or suspended above it. Motor pattern activities and the coefficient of variation for inter-spike-interval of motor outputs were increased under suspended conditions during circular muscle contraction. These results indicate that sensory feedback modulates the pattern of motor activity in the earthworm during locomotion. (C) 2004 Published by Elsevier Ireland Ltd and The Japan Neuroscience Society.
  • Yoshiichiro Kitamura, Hiroto Ogawa, Kotaro Oka
    Talanta 61 (5) 717 - 724 0039-9140 2003/12/04 [Refereed][Not invited]
     
    Nitric oxide (NO) is an important mediator responsible for numerous physiological phenomena. Transient levels of NO in biological systems usually range from nanomolar to micromolar concentrations, with a rapid return to basal levels normally seen following these increases. Because NO can diffuse only over a local area in limited time due to such low levels of production and due to its short life-time prior to degradation, high spatial and temporal resolutions are required for direct and continuous NO measurement if the physiological role of NO is to be investigated in any system. For such purposes, analytical methods based on bio-imaging and electrochemical techniques for the measurement of NO are useful. In this paper, we describe the successful application of these methods to a number of biological systems. Specifically, complementary application of these methods demonstrate that it is possible to detect real-time NO production from nervous tissue with high spatial and temporal resolutions. © 2003 Elsevier B.V. All rights reserved.
  • T Kubota, K Tokuno, J Nakagawa, Y Kitamura, H Ogawa, Y Suzuki, K Suzuki, K Oka
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 303 (1) 332 - 336 0006-291X 2003/03 [Refereed][Not invited]
     
    Mg2+ buffering mechanisms in PC12 cells were demonstrated with particular focus on the role of the Na+/Mg2+ transporter by using a newly developed Mg2+ indicator, KMG-20, and also a Na+ indicator, Sodium Green. Carbonyl cyanide p-(trifluoromethoxy) phenylhydrazone (FCCP), a protonophore, induced a transient increase in the intracellular Mg2+ concentration ([Mg2+](i)). The rate of decrease of [Mg2+](i) was slower in a Na+-free extracellular medium, suggesting the coupling of Na+ influx and Mg2+ efflux. Na+ influxes were different for normal and imipramine-(a putative inhibitor of the Na+/Mg2+ transporter) containing solutions. FCCP induced a rapid increase in [Na+](i) in the normal solution, while the increase was gradual in the imipramine-containing solution. The rate of decrease of [Mg2+](i) in the imipramine-containing solution was also slower than that in the normal solution. From these results, we show that the main buffering mechanism for excess Mg2+ depends on the Na+/Mg2+ transporter in PC12 cells.
  • K Mizutani, T Shimoi, Y Kitamura, H Ogawa, K Oka
    NEUROSCIENCE 121 (2) 473 - 478 0306-4522 2003 [Refereed][Not invited]
     
    In the ventral nervous system of the earthworm, a central pattern generator and motor neurons are activated during locomotion. We have previously reported that bath application of octopamine (OA) induces fictive locomotion in the earthworm, and the burst frequency of electrical activity from the first lateral nerves increases with OA concentration. However, there are no reports concerning locomotor neural networks in the earthworm. To identify neural networks involved in fictive locomotion, we optically monitored activity-dependent fluorescent staining in the earthworm ventral nerve cord (VNC) with a styryl dye, N-(3-triethylammoniumpropyl)-4-(4-(dibutylamino)styryl)pyridinium dibromide (FM1-43), and a confocal laser scanning microscope. OA induces FM1-43 fluorescence in a dose-dependent manner, with bright fluorescent spots of 3-10 mum in diameter observed to be localized around specified neurons in the segmental ganglion of the VNC. We compared OA dose-response curves for FM1-43 fluorescence with the bursting frequency for fictive locomotion, and found that two types of curves could be identified: one fluorescence response shows a similar dose-dependency to that of the burst frequency, while another response has a higher sensitivity to OA. From these results, we suggest that OA acts as one of the neuromoclulators for the earthworm locomotion. This is the first attempt to record motor and inter-neuronal activities simultaneously in a locomotor network in the earthworm. (C) 2003 IBRO. Published by Elsevier Ltd. All rights reserved.
  • H Ogawa, Y Baba, K Oka
    JOURNAL OF NEUROBIOLOGY 53 (1) 44 - 56 0022-3034 2002/10 [Refereed][Not invited]
     
    To understand the relationship between the propagation direction of action potentials and dendritic Ca2+ elevation, simultaneous measurements of intracellular Ca2+ concentration ([Ca2+](i)) and intradendritic membrane potential were performed in the wind-sensitive giant interneurons of the cricket. The dendritic Ca2+ transients induced by synaptically-evoked action potentials had larger amplitudes than those induced by backpropagating spikes evoked by antidromic stimulation. The amplitude of the [Ca2+](i) changes induced by antidromic stimuli combined with subthreshold synaptic stimulation was not different from that of the Ca2+ increases evoked by the backpropagating spikes alone. This result means that the synapfically activated Ca2+ release from intracellular stores does not contribute to enhancement of Ca2+ elevation induced by backpropagating spikes. On the other hand, the synaptically evoked action potentials were also increased at distal dendrites in which the Ca2+ elevation was enhanced. When the dendritic and axonal spikes were simultaneously recorded, the delay between dendritic spike and ascending axonal spike depended upon which side of the cercal nerves was stimulated. Further, dual intracellular recording at different dendritic branches illustrated that the dendritic spike at the branch arborizing on the stimulated side preceded the spike recorded at the other side of the dendrite. These results suggest that the spike-initiation site shifts depending on the location of the activated postsynaptic site. It is proposed that the difference of spike propagation manner could change the action potential waveform at the distal dendrite, and could produce synaptic activity-dependent Ca2+ dynamics in the giant interneurons. (C) Wiley Periodicals, Inc.
  • H Ogawa, Y Baba, K Oka
    JOURNAL OF NEUROBIOLOGY 50 (3) 234 - 244 0022-3034 2002/02 [Refereed][Not invited]
     
    The relationship between electrical activity and spike-induced Ca2+ increases in dendrites was investigated in the identified wind-sensitive giant interneurons in the cricket. We applied a high-speed Ca2+ imaging technique to the giant interneurons, and succeeded in recording the transient Ca2+ increases (Ca2+ transients) induced by a single action potential, which was evoked by presynaptic stimulus to the sensory neurons. The dendritic Ca2+ transients evoked by a pair of action potentials accumulated when spike intervals were shorter than 100 ms. The amplitude of the Ca2+ transients induced by a train of spikes depended on the number of action potentials. When stimulation pulses evoking the same numbers of action potentials were separately applied to the ipsi- or contra-lateral cercal sensory nerves, the dendritic Ca2+ transients induced by these presynaptic stimuli were different in their amplitude. Furthermore, the side of presynaptic stimulation that evoked larger Ca2+ transients depended on the location of the recorded dendritic regions. This result means that the spike-triggered Ca2+ transients in dendrites depend on postsynaptic activity. It is proposed that Ca2+ entry through voltage-dependent Ca2+ channels activated by the action potentials will be enhanced by excitatory synaptic inputs at the dendrites in the cricket giant interneurons. (C) 2002 John Wiley Sons, Inc.
  • Fictive locomotion induced by octopamine in the earthworm
    K Mizutani, H Ogawa, J Saito, K Oka
    JOURNAL OF EXPERIMENTAL BIOLOGY 205 (2) 265 - 271 0022-0949 2002/01 [Refereed][Not invited]
     
    We investigated the function of octopamine (OA) as a motor pattern inducer in the earthworm Eisenia fetida. We used semi-intact preparations, consisting of 20 sequential segmental ganglia of the ventral nerve cord (VNC) together with the body wall from the middle of the animal. Bath-application of 10(-4) mol l(-1) OA to the semi-intact preparation induced phasic muscle contractions, which are consistent with crawling. In the isolated VNC, OA induced bursts of motor neuron activity in the first lateral nerves. Burst frequency increased with OA concentration, with a large increase in activity observed in the range 10(-6)-10(-4) mol l(-1). At 10(-4) mol l(-1), the coefficient of variation of burst periods (BPs) was smaller than that seen upon application of OA at other concentrations, which is indicative of rhythmic bursts. These rhythmic bursts propagated along the VNC from the anterior to posterior, with a propagation velocity ranging from 60 to 110 mm s(-1). This, velocity is consistent with the propagation velocity, of muscle contraction during crawling behavior in the intact earthworm. From these results, we conclude that fictive crawling motor patterns are observed at 10(-4) mol (l-1) OA, and that OA can induce rhythmic bursts in the isolated VNC of the earthworm.
  • Y Kitamura, Y Naganoma, H Horita, H Ogawa, K Oka
    NEUROSCIENCE RESEARCH 41 (2) 129 - 134 0168-0102 2001/10 [Refereed][Not invited]
     
    Effect of serotonin on nitric oxide (NO) production in the ventral nerve cord (VNC) of the earthworm Eisenia fetida was investigated by a bio-imaging and an electrochemical technique. In the bio-imaging, the spatial pattern of NO production in VNC was visualized using an NO-specifle fluorescent dye, diaminofluorescein-2 diacethyl (DAF-2 DA). Application of serotonin (100 muM) increased NO production in VNC by about 65% (P < 0.05), compared with basal NO production. The increase was mainly from the nitergic neurons in the ventral side of VNC. In the electrochemical technique. real-time basal and serotonin-induced No production was estimated with an NO-specific electrode. On the ventral surface of VNC. the estimated basal NO production was stable at 200 +/- 52 nM. and was transiently augmented to 840 +/- 193 nM by the addition of 10 muM serotonin. In conclusion, the estimated basal NO production in the earthworm VNC is relatively high compared with other nervous systems earlier reported, and transiently augmented by serotonin. Our results suggest that NO signaling in VNC is involved in neuromodulation by serotonin. (C) 2001 Elsevier Science Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
  • Kitamura Y, Naganoma Y, Horita H, Tsuji N, Shimizu R, Ogawa H, Oka K
    Neuroscience research 40 (2) 175 - 181 0168-0102 2001/06 [Refereed][Not invited]
  • Hiroto Ogawa, Yoshichika Baba, Kotaro Oka
    Journal of Neurobiology 46 (4) 301 - 313 0022-3034 2001 [Refereed][Not invited]
     
    An in vivo Ca2+ imaging technique was applied to examine the cellular mechanisms for attenuation of wind sensitivity in the identified primary sensory interneurons in the cricket cercal system. Simultaneous measurement of the cytosolic Ca2+ concentration ([Ca2+]i) and membrane potential of a wind-sensitive giant interneuron (GI) revealed that successive air puffs caused the Ca2+ accumulation in dendrites and diminished the wind-evoked bursting response in the GI. After tetanic stimulation of the presynaptic cercal sensory nerves induced a larger Ca2+ accumulation in the GI, the wind-evoked bursting response was reversibly decreased in its spike number. When hyperpolarizing current injection suppressed the [Ca2+]i elevation during tetanic stimulation, the wind-evoked EPSPs were not changed. Moreover, after suprathreshold tetanic stimulation to one side of the cercal nerve resulted in Ca2+ accumulation in the GI's dendrites, the slope of EPSP evoked by presynaptic stimulation of the other side of the cercal nerve was also attenuated for a few minutes after the [Ca2+]i had returned to the prestimulation level. This short-term depression at synapses between the cercal sensory neurons and the GI (cercal-to-giant synapses) was also induced by a depolarizing current injection, which increased the [Ca2+]i, and buffering of the Ca2+ rise with a high concentration of a Ca2+ chelator blocked the induction of short-term depression. These results indicate that the postsynaptic Ca2+ accumulation causes short-term synaptic depression at the cercal-to-giant synapses. The dendritic excitability of the GI may contribute to postsynaptic regulation of the wind-sensitivity via Ca2+-dependent depression. © 2001 John Wiley & Sons, Inc.
  • S Kobayashi, H Sadamoto, H Ogawa, Y Kitamura, K Oka, K Tanishita, E Ito
    NEUROSCIENCE RESEARCH 38 (1) 27 - 34 0168-0102 2000/09 [Refereed][Not invited]
     
    Although there are many lines of evidence for both the presence of nitric oxide synthase (NOS) in the central nervous system (CNS) and the effects of NO on activating and modulating the feeding circuit in Lymnaea stagnalis, there has been no direct evidence that NO generation in the CNS accompanies feeding behavior. In the present study, we used a NO specific electrode to measure the increase in NO concentration around the buccal ganglia when the lips of semi-intact preparations of L. stagnalis were stimulated by sucrose. The NO concentration of the buccal ganglia was significantly increased by an application of sucrose to the lips. A NO scavenger and a NOS inhibitor suppressed this increase in NO concentration. A pair of putative NO-generative neurons in the buccal ganglia, the B2 cells, are active during the inter-feeding phase, and the bursting of the B2 cell elicited by sucrose application starts simultaneously with the feeding response. The rhythmic pulses of NO generation corresponded well with the rhythmic bursting of the B2 cells, which itself corresponds to the 'fictive feeding response'. The present data provide the first direct evidence that NO is generated in the buccal ganglia of L, staganalis and is involved in a specific behavior such as Feeding. (C) 2000 Elsevier Science Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
  • Yoshiichiro Kitamura, Tomoyuki Uzawa, Kotaro Oka, Yutaka Komai, Hiroto Ogawa, Naosada Takizawa, Hirosuke Kobayashi, Kazuo Tanishita
    Analytical Chemistry 72 (13) 2957 - 2962 0003-2700 2000/07/01 [Refereed][Not invited]
     
    Nitric oxide (NO) is a gaseous mediator involved in various physiological phenomena, such as vasorelaxation and neurotransmission. Investigation of local cellular responses of NO production in vivo and in vitro requires a measurement method with a high spatial resolution. For selective NO measurement, we therefore developed a microcoaxial electrode whose tip diameter is less than 10 μm. Calibration using various concentrations of NO (0.1-1.0 μM) showed that the electrode has good linearity (r = 0.99) and its detection limit is 0.075 μM (S/N = 3). We verified the applicability of this electrode to in vivo and in vitro local measurement NO released from bovine aortic cultured endothelial cells (BAECs) stimulated by acetylcholine (ACh). After the addition of ACh, a transient increase in NO concentration was detected by the electrode. In the presence of N(G)-nitro-L-arginine methyl ester (L-NAME), a putative NO synthase inhibitor, NO release (peak NO concentration) from BAECs was significantly less than that in the absence of L-NAME (0.18 ± 0.04 μMvs 0.47 ± 0.13 P < 0.01). After removal of L-NAME, NO release partially recovered (0.39 ± 0.10 μM). In conclusion, the microcoaxial electrode was successfully applied to direct and continuous NO measurement in biological systems.
  • S Kobayashi, H Ogawa, Fujito, V, E Ito
    NEUROSCIENCE LETTERS 285 (3) 209 - 212 0304-3940 2000/05 [Refereed][Not invited]
     
    Fictive feeding activity was monitored in the buccal ganglia of semi-intact preparations of the pond snail, Lymnaea stagnalis, to examine the effects of nitric oxide (NO) released from motoneurons innervating the esophagus on the feeding response. The present results suggest that first; even the low concentration of constitutive NO precisely regulates the feeding rhythm by suppressing high frequency feeding responses; second, that the high concentration of NO released after activation of the feeding central pattern generator following appetitive stimulation of the lips suppresses the feeding rate, resulting in recurrent inhibition. This is the first direct evidence that NO can function to suppress rhythmic activity in the brain. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
  • S Kojima, H Ogawa, T Kouuchi, T Nidaira, T Hosono, E Ito
    NEUROSCIENCE 100 (4) 893 - 900 0306-4522 2000 [Refereed][Not invited]
     
    To directly monitor the glial activity in the CNS of the pond snail, Lymnaea stagnalis, we optically measured the electrical responses in the cerebral ganglion and median lip nerve to electrical stimulation of the distal end of the median lip nerve. Using a voltage-sensitive dye, RH155, we detected a composite depolarizing response in the cerebral ganglion, which consisted of a fast transient depolarizing response corresponding to a compound action potential and a slow depolarizing response. The slow depolarizing response was observed more clearly in an isolated median lip nerve and also detected by extracellular recording. In the median lip nerve preparation, the slow depolarizing response was suppressed by an L-type Ca2+ channel blocker, nifedipine, and was resistant to tetrodotoxin and Na+-free conditions. Together with the fact that a delay from the compound action potential to the slow depolarizing response was not constant, these results suggested that the slow depolarizing response was not a postsynaptic response. Because the signals of the action potentials appeared on the saturated slow depolarizing responses during repetitive stimulation, the slow depolarizing response was suggested to originate from glial cells. The contribution of the L-type Ca2+ current to the slow depolarizing response was confirmed by optical recording in the presence of Ba2+ and also supported by intracellular Ca2+ measurement. Our results suggested that electrical stimulation directly triggers glial Ca2+ entry through L-type Ca2+ channels, providing evidence for the generation of glial depolarization independent of neuronal activity in invertebrates. (C) 2000 IBRO. Published by Elsevier Science Ltd. All rights reserved.
  • Hiroto Ogawa, Yoshichika Baba, Kotaro Oka
    Journal of Neurobiology 44 (1) 45 - 56 0022-3034 2000 [Refereed][Not invited]
     
    Identified wind-sensitive giant interneurons in the cricket's cercal sensory system integrate cercal afferent signals and release an avoidance behavior. A calcium-imaging technique was applied to the giant interneurons to examine the presence of the voltage-dependent Ca2+ channels (VDCCs) in their dendrites. We found that presynaptic stimuli to the cercal sensory nerve cords elevated the cytosolic Ca2+ concentration ([Ca2+](i) in the dendrites of the giant interneurons. The dendritic Ca2+ rise coincided with the spike burst of the giant interneurons, and the rate of Ca2+ rise depended on the frequency of the action potentials. These results suggest that the action potentials directly caused [Ca2+](i) increase. Observation of the [Ca2+](i) elevation induced by depolarizing current injection demonstrates the presence of the VDCCs in the dendrites. Although hyperpolarizing current injection into the giant interneuron suppressed action potential generation, EPSPs could induce no [Ca2+](i) increase. This result means that ligand-gated channels do not contribute to the synaptically stimulated Ca2+ elevation. On the other hand, antidromically stimulated spikes also increased [Ca2+](i) in all cellular regions including the dendrites. And bath application of a mixture of Ni2+, Co2+, and Cd2+ or tetrodotoxin inhibited the [Ca2+](i) elevation induced by the antidromic stimulation. From these findings, we suppose that the axonal spikes antidromically propagate and induce the Ca2+ influx via VDCCs in the dendrites. The spike-dependent Ca2+ elevation may regulate the sensory signals processing via second-messenger cascades in the giant interneurons. (C) 2000 John Wiley and Sons. Inc.
  • H Ogawa, Y Baba, K Oka
    NEUROSCIENCE LETTERS 275 (1) 61 - 64 0304-3940 1999/11 [Refereed][Not invited]
     
    In vivo Ca2+ imaging was applied to the cricket median giant interneuron (MGI), to visualize the dendritic processing of mechanosensory signals. Wind stimulation (air-puff) to the cerci induced a transient increase in the cytosolic Ca2+ concentration ([Ca2+](i)) in the MGI with a latency of a few seconds, suggesting the release of Ca2+ from the intracellular store site in the MGI. The amplitude of the transient increase in [Ca2+](i) in the dendrites depended on the direction of the air-puff, and the increase in [Ca2+](i) evoked by the air-puff was suppressed by the hyperpolarizing current injection which blocked the generation of action potentials. These results indicate that the action potential is necessary to the direction-sensitive increase in [Ca2+](i) induced by wind stimulation. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
  • R Shimizu, K Oka, H Ogawa, K Suzuki, J Saito, K Mizutani, K Tanishita
    NEUROSCIENCE LETTERS 268 (3) 159 - 162 0304-3940 1999/06 [Refereed][Not invited]
     
    In the centra I nervous system of the earthworm, sensory and motor neurons have direct synapses on th ree giant fibers. To determine the locations of synapses and neural network activated by mechanical stimuli, we optically monitored the activity-dependent staining in the earthworm ventral nerve cord with a styryl dye, N-(3-triethylammoniumpropyl)-4-(4-(dibutylamino)styryl)pyridinium dibromide (FM1-43), and a confocal laser scanning microscope. When scratch stimulus was applied to the body wall of the earthworm, bright fluorescent spots with 3-10 mu m in diameter localized only in the stimulated segmental ganglion of the ventral nerve cord. The fluorescent intensity of these spots decreased during dye-free high K+ saline incubation. These results suggest that FM 1-43 is useful for activity-dependent staining of invertebrate neurons and their synaptic regions as well as vertebrate nervous system. (C) 1999 Published by Elsevier Science Ireland Ltd. All rights reserved.
  • K Oka, Y Baba, H Ogawa
    ICONIP'98: THE FIFTH INTERNATIONAL CONFERENCE ON NEURAL INFORMATION PROCESSING JOINTLY WITH JNNS'98: THE 1998 ANNUAL CONFERENCE OF THE JAPANESE NEURAL NETWORK SOCIETY - PROCEEDINGS, VOLS 1-3 1239 - 1242 1998 [Refereed][Not invited]
     
    Relationship between intracellular Ca mobilization and synaptic plasticity in the insect nervous system was investigated with confocal laser scanning microscopy and a conventional electrophysiological method. Interneurons (postsynaptic neurons) of a terminal abdominal ganglion (TAG) were visualized by injecting a fluorescent Ca2+ probe, Calcium Green-1, and wind stimuli were applied to the sensory hair neurons (presynaptic cells) in cricket. High frequency wind stimulus increased intracellular free Ca2+ concentration ([Ca2+](i)), especially at the dendrites. This dendritic Ca2+ increase caused the attenuation of excitatory postsynaptic potentials (EPSPs). The firing of the postsynaptic neuron was requisite for [Ca2+](i) increase. From these results, we suggest that the action potential of the postsynaptic neuron back-propagates to the postsynaptic dendrites, and increases the [Ca2+](i) locally. The postsynaptic neuron could recognize, from the local dendritic [Ca2+](i) increase, that the pre- and postsynaptic neurons are co-active, and reduce the synaptic efficacy.
  • H Ogawa, Y Baba, K Oka
    NEUROSCIENCE LETTERS 219 (1) 21 - 24 0304-3940 1996/11 [Refereed][Not invited]
     
    In order to understand dendritic information processing, we examined spatio-temporal pattern of intracellular Ca2+ changes in cereal sensory interneurons of the cricket, We used a fluorescent imaging technique with confocal laser-scanning microscopy and a fluorescent calcium indicator, 'Calcium Green 1'. Electrical stimulation of cereal sensory nerves induced Ca2+ increase on local dendritic regions in these interneurons. The Ca2+ responses in several dendritic arborizations differed from each other in their amplitude, latency and duration, depending on direction that the cereal nerve was stimulated. These results suggest that synaptic inputs coding directional wind signals are topographically arranged on the dendrite, and that the dynamics of Ca2+ accumulation contribute to integrative processing of the synaptic inputs.
  • Physiological basis of the earthworm ventral nerve cord. II. Glutamate receptor subtypes on the median giant fiber.
    Oka K, Ogawa H
    Bioimages 4 149 - 156 0919-2719 1996 [Refereed][Not invited]
  • Physiological basis of the earthworm ventral nerve cord. I. Heterogeneity of cellular mechanisms underlying calcium mobilization.
    Ogawa H, Oka K
    Bioimages 4 137 - 147 0919-2719 1996 [Refereed][Not invited]
  • MOTOR PATTERN OF THE STINGING RESPONSE IN THE HONEYBEE APIS-MELLIFERA
    H OGAWA, Z KAWAKAMI, T YAMAGUCHI
    JOURNAL OF EXPERIMENTAL BIOLOGY 198 (1) 39 - 47 0022-0949 1995/01 [Refereed][Not invited]
     
    In the stinging response of the worker honeybee (Apis mellifera), rhythmic movements of the lancets on the stylet are produced by alternating contractions of a set of stinging muscles (a protractor, M198, and a retractor, M199) on each side during co-contraction of the frucula muscles (M197s) on both sides, In this study, stinging movements were elicited by tactile stimulation to the sternum in isolated abdomens, in intact animals and in preparations in which the connectives between the sixth and terminal abdominal ganglia were cut, There was a close relationship among the following three temporal variables of stinging motoneurone pattern: the interval between successive bursts of a stinging muscle, the duration of a burst and the time lag between the bursts of homologous stinging muscles on both sides. All of these variables increased linearly as the sting was inserted deeper into a soft object and the tension on the lancets increased. When sensory nerves from the proprioceptors (campaniform sensilla on the tapering sting shaft and hair plates at the basal cuticular plate) were cut on both sides, the relative timing of bursts of homologous stinging muscles on both sides and antagonistic stinging muscles on each side became more variable, When a proprioceptive input was removed from one side during penetration of the sting, the frequency of the bursts of stinging muscles was higher and the duration of bursts was shorter on the cut side than on the intact side; nevertheless, a sting muscle was still activated out of phase with its antagonistic muscle on the ipsilateral side and its homologous muscle on the contralateral side. These results suggest that the motor pattern driving the rhythmic movements of stinging muscles is produced by a central pattern generator consisting of a pair of oscillators located in the terminal abdominal ganglion and that the precise timing of the motor pattern in a hemiganglion is controlled mainly by proprioceptive inputs on its own side.
  • K OKA, H OGAWA, S FUJITA
    NEUROSCIENCE LETTERS 179 (1-2) 41 - 44 0304-3940 1994/09 [Refereed][Not invited]
     
    We investigated glutamate-induced neuron response in the ventral nerve cord of the earthworm (Eisenia foetida) using a voltage-sensitive dye-imaging technique. Isolated earthworm ganglia were stained by fluorescence voltage-sensitive dye, RH414, and voltage image was acquired by a conventional charge-coupled device (CCD) technique or a confocal laser scanning microscope. The fluorescence images before and during the glutamate stimulation was acquired and the relative fluorescence change was imaged as pseudo-color. Bath-applied glutamate (1 mM) depolarized many neurons on the ventral side, and in the three giant fibers on the dorsal side.
  • H OGAWA, K OKA, S FUJITA
    NEUROSCIENCE LETTERS 179 (1-2) 45 - 49 0304-3940 1994/09 [Refereed][Not invited]
     
    We examined a spatio-temporal pattern of intracellular free Ca2+ concentration in the giant axons of the earthworm, Eisenia foetida, with a fluorescent imaging technique using conforcal laser-scanning microscope and calcium indicator, 'Calcium Green 1'. Electrical tetanic stimulation applied to the nerve cord induced calcium waves along the giant axon. The calcium waves propagated both anteriorly and posteriorly with various speeds, and sometimes were split into several waves with different velocities. The results suggest that some types of calcium-releasing mechanisms may be associated with the calcium wave propagation.

Books etc

  • Optical recording methods ~How to measure of neural activities with Calcium imaging~
    Ogawa, H, Miller, J.P (ContributorPp 285-302, In: The cricket as a model Organism; Development, Regeneration, and Behavior)
    Springer Japan 2016
  • Cercal system-mediated anti-predator behaviors
    Baba, Y, Ogawa, H (ContributorPp 211-228, In: The cricket as a model Organism; Development, Regeneration, and Behavior)
    Springer Japan 2016
  • Optical Imaging techniques for investigating the earthwormnervous system and its function
    Oka, K, Ogawa, H (ContributorPp. 89-99, In: Methods in Neuroethological Research)
    Springer Japan 2013
  • In vivo Ca2+ imaging of neuronal activity
    Hiroto Ogawa (ContributorPp 71-87, In: Methods in Neuroethological Research)
    Springer Japan 2013
  • グリッド細胞,場所細胞,ヘッブ則
    小川宏人 (ContributorPp. 132,424,483, In: 行動生物学辞典)
    東京化学同人 2013
  • Ogawa, H, Oka, K (Joint editor)
    Springer 2013 (ISBN: 9784431543305)
  • 針刺し運動—動き続けるミツバチの針
    小川宏人 (Contributorpp. 194-212, in 「動物の「動き」の秘密にせまる—運動系の比較生物学」)
    共立出版 2009
  • コオロギの電気生理学実験
    小川宏人 (Contributorpp. 58-64, in「身近な動物を使った実験4—ミツバチ,コオロギ,スズメガ」)
    三共出版 2009
  • コオロギ尾葉の機械感覚システムの機能構成
    小川宏人 (Single translationpp 231-243 in「昆虫ミメティクス —昆虫の設計に学ぶ—」)
    NTS 2008
  • 光学計測法が明らかにするニューロン内情報処理機構
    小川宏人 (Contributorpp 650-656, in「昆虫ミメティクス —昆虫の設計に学ぶ—」)
    NTS 2008
  • ミツバチの針刺し機構
    小川宏人 (Contributorpp 827-830, in「昆虫ミメティクス —昆虫の設計に学ぶ—」)
    NTS

Conference Activities & Talks

  • Hayashida Y, Shidara H, Kai K, Ogawa H
    The 41st Annual Meeting of the Japanese Society for Comparative Physiology and Biochemistry  2019/11
  • Kai K, Shidara H, Ando N, Ogawa, H.
    49th Annual Meeting of Society for Neuroscience  2019/10
  • Ogawa H, Tanaka K, Someya M, Shidara H
    49th Annual Meeting of Society for Neuroscience  2019/10
  • 本丸尚人,設樂久志,小川宏人
    日本動物学会第90回大会  2019/09
  • 佐藤和,設樂久志,小川宏人
    日本動物学会第90回大会  2019/09
  • OgawaH, Tanaka K, Someya M, Shidara H
    Neuro2019  2019/07
  • Makino K, Ando N, Shidara H, Hommaru N, Kanzaki R, Ogawa, H
    Living Machines 2019: Conference on Biomimetics and Biohybrid System  2019
  • コオロギの音源定位行動における行動戦略  [Not invited]
    本丸尚人, 設樂久志, 小川宏人
    日本動物学会第63回北海道支部大会  2019/03  札幌  日本動物学会北海道支部
  • コオロギ脳内の多感覚ニューロンの異種刺激に対する方向選択性の解析  [Not invited]
    林田賢樹, 設樂久志, 甲斐加樹来, 小川宏人
    日本動物学会第63回北海道支部大会  2019/03  札幌  日本動物学会北海道支部
  • Behavioral elements extraction and environmental manipulation in phonotaxis navigation of the cricket  [Invited]
    Hiroto Ogawa
    The 66th annual meeting of the ecological society of Japan  2019/03  Kobe  The Ecological Society of Japan
  • Neural substrates for auditory modulation of innate behavior in the crickets  [Invited]
    Hiroto Ogawa, Matasaburo Fukutomi, Makoto Someya
    2019 Spring Meeting, Acoustical Society of Japan  2019/03  Chofu  Acoustical Society of Japan
  • Phonotactic behaviors in freely-moving female crickets  [Not invited]
    Shidara H, Hommaru N, Ogawa H
    48th Annual Meeting of Society for Neuroscience  2018/11  San Diego  Society for Neuroscience
  • Trade-off between speed, directional accuracy and behavioral flexibility in action selection of the escape behavior in the cricket  [Not invited]
    Sato N, Shidara H, Ogawa H
    48th Annual Meeting of Neuroscience  2018/11  San Diego  Society for Neuroscience
  • Stimulus-intensity impacts on direction encoding and its temporal dynamics in insect mechanosensory projection neurons  [Not invited]
    Ogawa H, Tanaka K, Someya M, Shidara H
    48th Annual Meeting of Society for Neuroscience  2018/11  San Diego  Society for Neuroscience
  • コオロギ音源定位行動におけるナビゲーション戦略  [Not invited]
    設樂久志, 本丸尚人, 小川宏人
    Neuroscience 2018—第41回日本神経科学大会  2018/07  神戸  日本神経科学学会
  • コオロギ気流応答性投射ニューロンにおける刺激速度依存的な方向選択性修飾の解析  [Not invited]
    田中寿希, 染谷真琴, 設樂久志, 小川宏人
    Neuroscience 2018—第41回日本神経科学大会  2018/07  神戸  日本神経科学学会
  • コオロギ感覚系介在ニューロンの多感覚統合における線形性は活動レベルに依存する  [Not invited]
    染谷真琴, 小川宏人
    Neuroscience 2018―第41回日本神経科学大会  2018/07  神戸  日本神経科学学会
  • 機械学習による生体ナビゲーションの軌跡分析:コオロギ逃避行動における時系列データ解析  [Not invited]
    福富又三郎, 設樂久志, 尾原和也, 西和弥, 佐久間拓人, 前川卓也, 竹内一郎, 小川宏人
    Neuroscience 2018—第41回日本神経科学大会  2018/07  神戸  日本神経科学学会
  • 仮想現実環境を用いた昆虫の定位行動における複数感覚の役割の解析  [Not invited]
    牧野航己, 安藤規泰, 設樂久志, 本丸尚人, 神崎亮平, 小川宏人
    日本動物学会第70回関東支部大会  2018/03  Tokyo
  • Action selection between running and jump in the wind-elicited escape behaviors of the cricket.  [Not invited]
    Sato N, Ogawa H
    日本比較生理生化学会第39回大会  2017/11  Fukuoka
  • Virtual auditory navigation in crickets.  [Not invited]
    Ando N, Shidara, H, Honmaru N, Kanzaki R, Ogawa H
    日本比較生理生化学会第39回大会  2017/11  Fukuoka
  • Action selection between walking and jump in the wind-elicited escape behavior of the cricket.  [Not invited]
    Sato N, Ogawa H
    47th Annual Meeting of Society for Neuroscience  2017/11  Washington, DC
  • Crickets modulate wind-elicited escape behavior depending on auditory context with sound carrier frequency.  [Not invited]
    Fukutomi M, Ogawa H
    47th Annual Meeting of Society for Neuroscience  2017/11  Washington, DC
  • Coincident multisensory inputs enhance bursting activity via large and long-lasting EPSPs in insect auditory neuron.  [Not invited]
    Someya M, Ogawa H
    47th Annual Meeting of Society for Neuroscience  2017/11  Washington, DC
  • Action selection for escape behavior in the cricket.  [Not invited]
    Ogawa H, Sato N, Fukutomi M
    The 44th Naito Conference on Decision Making in the Brain-Motivation, Prediction, and Learning  2017/10  Sapporo
  • コオロギは聴覚状況に応じて気流逃避行動を変化させる  [Not invited]
    福富又三郎, 小川宏人
    日本動物学会第88回大会  2017/09  Toyama
  • コオロギ気流誘発性逃避行動における刺激パラメータ依存的行動選択  [Not invited]
    佐藤和, 小川宏人
    日本動物学会第88回大会  2017/09  Toyama
  • コオロギ気流誘発性逃避行動における行動選択  [Not invited]
    佐藤和, 小川宏人
    Neuroscience 2017―第40回日本神経科学大会  2017/07  千葉
  • コオロギ同定投射ニューロンにおける聴覚及び機械感覚入力の多感覚統合  [Not invited]
    染谷真琴, 小川宏人
    Neuroscience 2017―第40回日本神経科学大会  2017/07  千葉
  • Acoustic stimulus impacts on directional variability of wind-elicited walking behavior in the cricket.  [Not invited]
    Fukutomi M, Ogawa H
    46th Annual Meeting of Society for Neuroscience  2016/11  San Diego
  • Diversity of GABAergic inhibitory impacts on dendritic integration for directional tuning in insect mechanosensory projection neurons.  [Not invited]
    Ogawa H, Mitani R
    46th Annual Meeting of Society for Neuroscience  2016/11  San Diego
  • コオロギ気流誘導性歩行運動と下行性神経活動は先行する聴覚刺激によって修飾される  [Not invited]
    福富又三郎, 小川宏人
    Neuroscience 2016―第39回日本神経科学大会  2016/07  横浜
  • コオロギの初期感覚情報処理における多感覚統合  [Not invited]
    染谷真琴, 小川宏人
    Neuroscience 2016―第39回日本神経科学大会  2016/07  横浜
  • コオロギ気流誘発性逃避行動における成虫脱皮後の経時的変化  [Not invited]
    佐藤和, 小川宏人
    Neuroscience 2016―第39回日本神経科学大会  2016/07  横浜
  • 昆虫の機械感覚性投射ニューロンにおける樹状突起カルシウムシグナルから予測される活動電位の空間動態  [Not invited]
    小川宏人, 三谷瑠里子
    Neuroscience 2016―第39回日本神経科学大会  2016/07  横浜
  • Preceding auditory inputs modulate responsiveness and orientation in wind-elicited walking behavior in the cricket.  [Not invited]
    Fukutomi M, Ogawa H
    45th Annual Meeting of Society for Neuroscience  2015/10  Chicago
  • Direction-specific adaptation in neuronal and behavioral responses of cercal sensory system in the cricket.  [Not invited]
    Ogawa H, Mitani R, Oka K
    45th Annual Meeting of Society for Neuroscience  2015/10  Chicago
  • 先行する音刺激はコオロギの気流逃避行動を修飾する  [Not invited]
    福富又三郎, 小川宏人
    日本動物学会第86回大会  2015/09  新潟
  • Temporal relationships between multisensory stimuli have modulatory effects on escape behavior in the crickets.  [Not invited]
    Ogawa H, Fukutomi M
    International Symposium on the Science of Mental Time  2015/09  Tokyo
  • 先行する音刺激はコオロギの気流誘導性逃避行動を修飾する  [Not invited]
    福富又三郎, 小川宏人
    Neuroscience 2015―第38回日本神経科学大会  2015/07  神戸
  • 機械感覚性投射ニューロン樹状突起での方向選択性形成過程に対するGABA作動性抑制性入力の効果  [Not invited]
    小川宏人, 三谷瑠里子
    Neuroscience 2015―第38回日本神経科学大会  2015/07  神戸
  • Preceding auditory cue modulates wind-elicited walking behavior in the cricket.  [Not invited]
    Fukutomi, M, Someya, M, Ogawa, H
    脳と心のメカニズム 第15回冬のワークショップ  2015/01  留寿都
  • Auditory modulation of wind-elicited walking behavior in the cricket.  [Not invited]
    Fukutomi M, Someya M, Ogawa H
    44th Annual Meeting of Society for Neuroscience  2014/11  Washington, DC
  • Estimation of neuronal assembly encoding directional information by decoding method.  [Not invited]
    Someya M, Ogawa H
    44th Annual Meeting of Society for Neuroscience  2014/11  Washington, DC
  • Population coding of walking locomotion by descending neural activities in the cricket.  [Not invited]
    Ogawa H, Shudo T, Someya M, Haruno M
    44th Annual Meeting of Society for Neuroscience  2014/11  Washington, DC
  • 昆虫の投射ニューロンにおける樹状突起Ca2+上昇はシナプス入力によって修飾される活動電位波形に依存する  [Not invited]
    小川宏人, 三谷瑠里子
    日本生物物理学会第52回年会  2014/09  札幌
  • コオロギの気流誘導性行動に対する先行聴覚刺激のクロスモーダル効果  [Not invited]
    福富又三郎, 染谷真琴, 小川宏人
    Neuroscience 2014―第37回日本神経科学大会  2014/09  横浜
  • 上行性投射ニューロンの気流応答における三次元方向感受性への重力効果  [Not invited]
    谷村佳奈子, 小川宏人
    Neuroscience 2014―第37回日本神経科学大会  2014/09  横浜
  • コオロギの音刺激と気流刺激に応答する異種感覚上行性ニューロン  [Not invited]
    染谷真琴, 小川宏人
    Neuroscience 2014―第37回日本神経科学大会  2014/09  横浜
  • 気流応答性投射ニューロンの方向選択性形成に関与する樹状突起内統合メカニズム  [Not invited]
    三谷瑠里子, 小川宏人
    Neuroscience 2014―第37回日本神経科学大会  2014/09  横浜
  • Sparse Linear Regressionによる下行性神経活動からの昆虫歩行運動の推定  [Not invited]
    小川宏人, 首藤智宏, 染谷真琴, 春野雅彦
    Neuroscience 2014―第37回日本神経科学大会  2014/09  横浜
  • Population coding of directional information of cercal sensory stimulus and wind-elicited locomotion.  [Not invited]
    Ogawa, H
    Hokkaido Neuroethology Workshops 2014  2014/07  Sapporo
  • Preceding auditory cue modulates walking direction in wind-elicited escape behavior in the cricket.  [Not invited]
    Fukutomi M, Someya M, Ogawa H
    2014 ICN/JSCPB  2014/07  Sapporo
  • Multisensory integration of auditory and cercal sensory inputs by ascending projection neurons in the cricket.  [Not invited]
    Someya M, Ogawa H
    2014 ICN/JSCPB  2014/07  Sapporo
  • Population coding of directional information of cercal sensory stimulus and wind-elicited locomotion  [Invited]
    Ogawa H
    Hokkaido Neuroethology Workshops 2014 "Ethology, neuroscience and genetics in crickets: How can they meet?"  2014/07
  • 刺激方向情報をコードする上行性投射ニューロンアセンブリの推定  [Not invited]
    染谷真琴, 小川宏人
    脳と心のメカニズム 第14回冬のワークショップ  2014/01  留寿都
  • Population coding of stimulus direction by ascending cell assembly in cercal and auditory systems in the cricket  [Not invited]
    Ogawa H, Someya M
    43th Annual Meeting of Society for Neuroscience  2013/11  San Diego
  • Statistic prediction of cell assemblies encoding stimulus direction in multi-modal sensory systems of insect.  [Not invited]
    Ogawa H
    International Symposium on Prediction and Decision Making 2013  2013/10  Kyoto
  • 気流応答特性から推定されるコオロギ下行性ニューロン群の機能  [Not invited]
    首藤智宏, 大江桃子, 小川宏人
    日本動物学会第84回大会  2013/09  岡山
  • コオロギ気流感覚系における上行性神経活動の三次元バイアス解析  [Not invited]
    谷村佳奈子, 小川宏人
    日本動物学会北海道支部第58回大会  2013/08  札幌
  • Input-site dependency of dendritic Ca2+ responses results from difference in spike waveform in cricket giant interneurons.  [Not invited]
    Ogawa, H, Mitani, R
    日本比較生理生化学会第35回大会  2013/07  姫路
  • 異なる感覚モダリティーにおける方向情報の神経表現  [Not invited]
    染谷真琴, 小川宏人
    第36回日本神経科学大会,第56回日本神経化学会大会,第23回日本神経回路学会大会合同大会  2013/06  京都
  • In vivo エレクトロポレーション法を用いた成虫コオロギ脳における遺伝子発現パターンの制御  [Not invited]
    松本‐佐藤‐千尋, 設楽久志, 松田光司, 中村太郎, 三戸太郎, 松本幸久, 岡浩太郎, 小川宏人
    第36回日本神経科学大会,第56回日本神経化学会大会,第23回日本神経回路学会大会合同大会  2013/06  京都
  • 気流応答性ニューロンにおける樹状突起カルシウム応答による方向選択的入力分布の解析  [Not invited]
    三谷瑠里子, 小川宏人
    第36回日本神経科学大会,第56回日本神経化学会大会,第23回日本神経回路学会大会合同大会  2013/06  京都
  • 実行動下動物における方向情報の脳内表現と変換機構の解明と展開  [Invited]
    小川宏人
    「脳情報の解読と制御」領域さきがけ研究成果報告会  2013/01  東京
  • 球形トレッドミルシステムを用いた刺激方向依存的運動制御機構の解析  [Not invited]
    小川宏人
    計測自動制御学会システム・情報部門学術講演会  2012/11  名古屋
  • 刺激方向情報の抽出とコーディングの神経機構  [Invited]
    小川宏人
    私立大学戦略的研究基盤形成支援事業「網膜回路と視覚応答のシステムダイナミクス解明」プロジェクトセミナー  2012/11  草津
  • Distinct role of identified giant interneurons in directional control of wind-evoked walking behavior in the cricket.  [Not invited]
    Ogawa H, Oe M
    42th Annual Meeting of Society for Neuroscience  2012/10  New Orleans
  • コオロギ気流誘導性歩行の開始およびターン角度制御に関与する下行性神経活動  [Not invited]
    首藤智宏, 小川宏人
    Neuroscience 2012―第35回日本神経科学大会  2012/09  名古屋
  • コオロギ脳神経節における気流刺激応答の方向感受特性  [Not invited]
    梶田頼子, 小川宏人
    Neuroscience 2012―第35回日本神経科学大会  2012/09  名古屋
  • コオロギ気流誘導性歩行の方向性制御における巨大介在ニューロンの機能解析  [Not invited]
    小川宏人, 大江桃子
    Neuroscience 2012ー第35回日本神経科学大会  2012/09  名古屋
  • コオロギの気流誘導性歩行の運動制御に関与する下行性信号の解析  [Not invited]
    首藤智宏, 小川宏人
    日本動物学会北海道支部第57回大会  2012/08  札幌
  • Neuronal mechanism for directional-dependent plasticity in wind-evoked walking behavior of the cricket.  [Invited]
    Ogawa H
    The 2nd International Conference on the Cricket  2012/03  Tokushima
  • Neural control of walking orientation and body-axis angle in wind avoidance behavior in the cricket.  [Not invited]
    Ogawa H, Oe M
    41th Annual Meeting of Society for Neuroscience  2011/11  Washington, DC
  • 昆虫をモデルとした感覚-運動連関の可塑的変化の研究  [Invited]
    小川宏人
    国立精神・神経医療研究センター 神経研究所セミナー  2011/11  小平
  • コオロギ気流誘導性歩行時における脳神経節カルシウムイメージング  [Not invited]
    首藤智宏, 小川宏人
    日本動物学会第82回大会  2011/09  旭川
  • コオロギ脳神経節における気流刺激方向依存的な神経活動領域の可視化  [Not invited]
    梶田頼子, 小川宏人
    日本動物学会第82回大会  2011/09  旭川
  • コオロギ気流誘導性歩行の最初期運動における移動方向および体軸角度制御  [Not invited]
    大江桃子, 小川宏人
    日本動物学会第82回大会  2011/09  旭川
  • コオロギ気流誘発性歩行における運動方向および体軸角度制御の神経基盤  [Not invited]
    小川宏人, 大江桃子
    Neuroscience 2011ー第34回日本神経科学大会  2011/09  横浜
  • 昆虫気流感覚系をモデルとした刺激方向情報処理と運動出力への変換機構の解明  [Invited]
    小川宏人
    大阪大学理学部生物科学セミナー  2011/09  豊中
  • Neural mechanism for directional control of wind-evoked walking behavior in the cricket.  [Not invited]
    Oe M, Ogawa H
    8th International Congress of Comparative Physiology and Biochemistry  2011/05  Nagoya
  • Directional-dependent plasticity in neural and behavioral responses to air currents in the cricket.  [Invited]
    Ogawa H
    8th International Congress of Comparative Physiology and Biochemistry  2011/05  Nagoya
  • 昆虫における脳神経活動のin vivo高速イメージング  [Invited]
    小川宏人
    日本顕微鏡学会第67回学術講演会  2011/05  福岡
  • Relationships between spatio-temporal pattern of the dendritic Ca2+ accumulation and alternation of the directional selectivity in the identified projection interneurons.  [Not invited]
    Ogawa H, Oka K
    40th Annual Meeting of Society for Neuroscience  2010/11  San Diego
  • コオロギ気流誘導性歩行運動における体軸角度制御の解析  [Not invited]
    大江桃子, 小川宏人
    日本動物学会第81回大会  2010/09  東京
  • コオロギ脳神経節における気流刺激および聴覚刺激に対するカルシウム応答  [Not invited]
    小川宏人
    日本動物学会第81回大会  2010/09  東京
  • 反復刺激によって誘導される同定感覚介在ニューロンの樹状突起内Ca2+蓄積パターンと刺激方向依存的可塑性  [Not invited]
    小川宏人, 岡浩太郎
    Neuro 2010―第33回日本神経科学大会、第53回日本神経化学会大会および第20回日本神経回路学会大会 合同大会  2010/09  神戸
  • コオロギ巨大介在ニューロンにおける連続気流刺激に伴う方向選択的応答性低下  [Not invited]
    小川宏人
    無脊椎動物神経研究会2010  2010/08  裾野
  • コオロギ気流誘導性歩行における体軸角度制御と神経節間連絡  [Not invited]
    大江桃子, 小川宏人
    日本動物学会北海道支部第56回大会  2010/08  旭川
  • Dendritic geometry of sensory interneurons implements decoding algorithm for synaptic extraction of sensory information  [Not invited]
    Ogawa, H, Oka, K
    2010年度包括型脳科学研究推進支援ネットワーク夏のワークショップ  2010/07  札幌
  • Directional-dependent plasticity in cercal-to-giant interneuron synapses in the cricket wind-sensitive system.  [Not invited]
    Ogawa H
    The 3rd International Symposium on Mobiligence  2009/11  Awaji
  • アオリイカが表出する模様の中の動的変化  [Not invited]
    鈴木真美子, 木村哲也, 小川宏人, 堀田耕司, 岡浩太郎
    日本生物物理学会第47回年会  2009/10  徳島
  • コオロギ尾葉感覚系における連続気流刺激に対する方向依存的可塑性  [Not invited]
    小川宏人, 大江桃子, 岡浩太郎
    日本生物物理学会第47回年会  2009/10  徳島
  • コオロギの連続気流刺激に対する逃避行動馴化と尾葉感覚系の方向依存的可塑性  [Not invited]
    小川宏人, 大江桃子
    日本動物学会第80回大会  2009/09  静岡
  • シマミミズにおけるcAMP response element binding protein 1 (CREB1) の同定  [Not invited]
    渡邊康佑, 長谷純崇, 下井利修, 小川宏人, 堀田耕司, 岡浩太郎
    日本生物物理学会第46回年会  2008/12  福岡
  • 模様形成に関わるイカ色素胞ユニットの同定とそのダイナミクスの解析  [Not invited]
    鈴木真美子, 木村哲也, 小川宏人, 堀田耕司, 岡浩太郎
    日本生物物理学会第46回年会  2008/12  福岡
  • コオロギキノコ体傘部における学習依存的なカルシウムシグナル  [Not invited]
    小川宏人, 岡浩太郎
    日本生物物理学会第46回年会  2008/12  福岡
  • Expression of cyclic AMP responsive element binding protein 1 (CREB1) in long-term memory formation in the earthworm Eisenia fetida.  [Not invited]
    Watanabe K, Hase S, Shimoi T, Ogawa H, Hotta K, Oka K
    38th Annual Meeting of Society for Neuroscience  2008/11  Washington, DC
  • Alteration of Mg2+ transport during 1-methyl-4-phenyl-pyridinium ion (MPP+) induced cell death in PC12 cells.  [Not invited]
    Shindo Y, Ogawa H, Hotta K, Oka K
    38th Annual Meeting of Society for Neuroscience  2008/11  Washington, DC
  • In vivo calcium imaging of mushroom body calyx in the tethered cricket for odor-taste conditioning.  [Not invited]
    Ogawa H, Oka K
    38th Annual Meeting of Society for Neuroscience  2008/11  Washington, DC
  • 嗅覚-味覚連合学習前後におけるコオロギキノコ体傘部のin vivoカルシウムイメージング  [Not invited]
    小川宏人, 岡浩太郎
    日本比較生理生化学会第30回大会  2008/07  札幌
  • コオロギ気流応答性巨大介在ニューロンにおける方向情報抽出アルゴリズム  [Invited]
    小川宏人
    21世紀COEプログラム「昆虫科学が拓く未来型食料環境学の創生」第25回昆虫科学セミナー  2008/01  京都
  • ミトコンドリアのマグネシウム輸送とその細胞死への影響の解析  [Not invited]
    新藤豊, 久保田健, 小松広和, 堀田耕司, 小川宏人, 鈴木孝治, 岡浩太郎
    日本生物物理学会第45回年会  2007/12  横浜
  • コオロギ気流応答性介在ニューロンの応答性に対するNOによる調節  [Not invited]
    小川宏人, 馬場欣哉, 北村美一郎, 青沼仁志, 岡浩太郎
    日本生物物理学会第45回年会  2007/12  横浜
  • コオロギ巨大介在ニューロンの気流応答性における方向依存的可塑性  [Not invited]
    小川宏人, 岡浩太郎
    Neuroscience 2008―第31回日本神経科学大会  2007/12  東京
  • Analysis of Arc mRNA expression in female zebra finch brain for song discrimination.  [Not invited]
    Fujimura A, Ogawa H, Hotta K, Oka K
    37th Annual Meeting of Society for Neuroscience  2007/11  San Diego
  • Analysis of memory-related proteins associated with classical conditioning of earthworm.  [Not invited]
    Watanabe K, Tsuchiya R, Ogawa H, Hotta K, Oka K
    37th Annual Meeting of Society for Neuroscience  2007/11  San Diego
  • イカ色素胞が形成する機能ユニットの経時的変化  [Not invited]
    鈴木真美子, 木村哲也, 小川宏人, 堀田耕司, 岡浩太郎
    日本動物学会第78回大会  2007/09  弘前
  • ミミズ古典的条件付けに伴う記憶形成関連タンパク質の解析  [Not invited]
    土屋亮, 渡邊康佑, 下井利修, 小川宏人, 堀田耕司, 岡浩太郎
    日本動物学会第78回大会  2007/09  弘前
  • 昆虫神経細胞の樹状突起形態に潜む感覚情報抽出アルゴリズム  [Invited]
    小川宏人
    Neuro 2007―第30回日本神経科学大会・第50回日本神経化学会大会・第17回日本神経回路学会大会合同大会  2007/09  横浜
  • Decoding algorithms implemented in dendritic design of cricket cercal sensory interneurons.  [Not invited]
    Ogawa H, Oka K
    8th International Congress of Neuroethology  2007/07  Vancouver, Canada
  • コオロギ最終腹部神経節における一酸化窒素の生理機能の解析  [Not invited]
    小川宏人, 馬場欣哉, 北村美一郎, 青沼仁志, 岡浩太郎
    日本比較生理生化学会第29回大会  2007/07  岡山
  • イカ色素胞が形成する生理的機能ユニットの解析  [Not invited]
    鈴木真美子, 木村哲也, 小川宏人, 青沼仁志, 北村美一郎, 堀田耕司, 岡浩太郎
    日本動物学会関東支部第59回大会  2007/03  八王子
  • Mitochondrial magnesium imaging.  [Not invited]
    Shindo Y, Kubota T, Komatsu H, Hotta K, Ogawa H, Suzuki , K, Oka K
    5th East Asian Biophysics Symposium & 44th Annual Meeting of Biophysical Society of Japan  2006/11  Okinawa
  • Analysis of vocal communication between mail and female zebra finches.  [Not invited]
    Oka K, Fujimura A, Hotta K, Ogawa H
    5th East Asian Biophysics Symposium & 44th Annual Meeting of Biophysical Society of Japan  2006/11  Okinawa
  • Acetylcholine-induced calcium-NO signaling in the cricket terminal abdominal ganglion.  [Not invited]
    Ogawa H, Kitamura Y, Aonuma H, Oka K
    5th East Asian Biophysics Symposium & 44th Annual Meeting of Biophysical Society of Japan  2006/11  Okinawa
  • Alterations of phosphorylation state are associated with memory formation in earthworm.  [Not invited]
    Tsuchiya R, Shimoi T, Ogawa H, Hotta K, Oka K
    36th Annual Meeting of Society for Neuroscience  2006/10  Atlanta
  • Acetylcholine enhances nitric oxide production in the terminal abdominal ganglion of the cricket, Gryllus bimaculatus.  [Not invited]
    Kitamura Y, Aonuma H, Oka K, Ogawa H
    36th Annual Meeting of Society for Neuroscience  2006/10  Atlanta
  • Peripheral nervous plexuses control squid chromatophore organs.  [Not invited]
    Suzuki M, Kimura T, Ogawa H, Aonuma H, Kitamura Y, Hotta K, Oka K
    36th Annual Meeting of Society for Neuroscience  2006/10  Atlanta
  • Analysis of local translation in growth cones of chick dorsal root ganglia.  [Not invited]
    Yamanami H, Honma K, Ogawa H, Kitamura Y, Hotta K, Oka K
    36th Annual Meeting of Society for Neuroscience  2006/10  Atlanta
  • Neural coding of high-frequency inputs in low-frequency spikes.  [Not invited]
    Miyamoto S, Ushiba J, Ogawa H, Oka K, Tomita Y
    36th Annual Meeting of Society for Neuroscience  2006/10  Atlanta
  • Relationships between dendritic geometry and algorithm for extraction of sensory information.  [Not invited]
    Ogawa H, Oka K
    36th Annual Meeting of Society for Neuroscience  2006/10  Atlanta
  • コオロギの逃避行動とプレ・ポストシナプス同時イメージング  [Invited]
    小川宏人
    日本動物学会第77回大会  2006/09  松江
  • イカ色素胞における神経制御メカニズム  [Not invited]
    鈴木真美子, 木村哲也, 小川宏人, 青沼仁志, 北村美一郎, 堀田耕司, 岡浩太郎
    日本動物学会第77回大会  2006/09  松江
  • ミミズ古典的条件付けによる長期記憶形成に伴う介在ニューロンの膜特性変化  [Not invited]
    渡邉光, 土屋亮, 下井利修, 小川宏人, 堀田耕司, 岡浩太郎
    日本動物学会第77回大会  2006/09  松江
  • Dendritic excitability and physiological roles in the cricket giant interneurons  [Invited]
    Ogawa, H
    無脊椎動物神経生物学シンポジウム  2006/09  さぬき
  • Physiological meaning of NO production in invertebrate nervous system.  [Not invited]
    Kitamura Y, Aonuma H, Oka K, Ogawa H
    The 2nd international workshop by research group of invertebrate nervous system of Japan  2006/08  Shodoshima
  • Decoding algorithm of sensory information in the cricket cercal sensory system.  [Not invited]
    Ogawa H
    The 2nd international workshop by research group of invertebrate nervous system of Japan  2006/08  Shodoshima
  • コオロギ巨大介在ニューロンの気流応答性における短期可塑性  [Not invited]
    小川宏人, 馬場欣哉, 岡浩太郎
    日本比較生理生化学会第28回大会  2006/07  浜松
  • イメージングによるミミズ這行CPGに関わる運動ニューロンの網羅的特徴付け  [Not invited]
    下井利修, 水谷賢史, 小川宏人, 堀田耕司, 岡浩太郎
    第29回日本神経科学大会  2006/07  京都
  • PC12細胞における細胞内カルシウムによるアクチン細胞骨格動態の変化  [Not invited]
    本間耕平, 新野祐介, 小川宏人, 堀田耕司, 岡浩太郎
    第29回日本神経科学大会  2006/07  京都
  • コオロギ最終腹部神経節における一酸化窒素(NO)産生機構と生理機能  [Not invited]
    北村美一郎, 青沼仁志, 岡浩太郎, 小川宏人
    日本生物物理学会第43回年会  2005/11  札幌
  • ミトコンドリア内Mg2+濃度変化の可視化  [Not invited]
    新藤豊, 久保田健, 小松広和, 堀田耕司, 鈴木孝治, 小川宏人, 岡浩太郎
    日本生物物理学会第43回年会  2005/11  札幌
  • 神経回路のダイナミクスと情報  [Not invited]
    渡辺恵, 小川宏人
    日本生物物理学会第43回年会  2005/11  札幌
  • 単一ニューロン樹状突起における入力統合と感覚情報抽出  [Invited]
    小川宏人, 岡浩太郎
    日本生物物理学会第43回年会  2005/11  札幌
  • Identification of long-term memory related neurons in classically conditioned earthworms.  [Not invited]
    Watanabe H, Tsuchiya R, Shimoi T, Ogawa H, Kitamura Y, Hotta K, Oka K
    35th Annual Meeting of Society for Neuroscience  2005/11  Washington D.C.
  • Serotonin inhibitors block short-term but not long-term memory formation in the earthworm.  [Not invited]
    Tsuchiya R, Watanabe H, Shimoi T, Ogawa H, Kitamura Y, Hotta K, Oka K
    35th Annual Meeting of Society for Neuroscience  2005/11  Washington D.C.
  • Analysis of cytoskeletel dynamics of growth cones in chick dorsal root ganglia by fluorescent speckle microscopy.  [Not invited]
    Yamanami H, Honma K, Ogawa H, Kitamura Y, Hotta K, Oka K
    35th Annual Meeting of Society for Neuroscience  2005/11  Washington D.C.
  • Nitric oxide production in the terminal abdominal ganglion of the cricket, GRYLLUS BIMACULATUS.  [Not invited]
    Kitamura Y, Aonuma H, Oka K, Ogawa H
    35th Annual Meeting of Society for Neuroscience  2005/11  Washington D.C.
  • Identification of the cetral pattern generator of the locomotion in the earthworm.  [Not invited]
    Shimoi T, Mizutani K, Kitamura Y, Ogawa H, Hotta K, Oka K
    35th Annual Meeting of Society for Neuroscience  2005/11  Washington D.C.
  • Simultaneous imaging of presynaptic and postsynaptic calcium signals reveals dendritic integration of synaptic parameters.  [Not invited]
    Ogawa H, Oka K
    35th Annual Meeting of Society for Neuroscience  2005/11  Washington D.C.
  • イカ色素胞を制御する末梢神経ネットワークの解析  [Not invited]
    鈴木真美子, 木村哲也, 青沼仁志, 北村美一郎, 小川宏人, 堀田耕司, 岡浩太郎
    日本動物学会第76回大会  2005/10  つくば
  • クロコオロギの最終腹部神経節におけるNO/cGMPシグナル伝達系  [Not invited]
    青沼仁志, 北村美一郎, 小川宏人, 岡浩太郎
    日本動物学会第76回大会  2005/10  つくば
  • ミミズ古典的条件付けによる長期・短期記憶形成過程でのセロトニンの機能  [Not invited]
    土屋亮, 渡邉光, 下井利修, 小川宏人, 北村美一郎, 岡浩太郎
    日本動物学会第76回大会  2005/10  つくば
  • ミミズ古典的条件付けにおけるセロトニンの役割  [Not invited]
    土屋亮, 渡邉光, 下井利修, 小川宏人, 北村美一郎, 堀田耕司, 岡浩太郎
    無脊椎動物神経研究会2005  2005/08  御殿場
  • コオロギ気流感覚系における方向性情報の抽出と統合機構  [Not invited]
    小川宏人
    無脊椎動物神経研究会2005  2005/08  御殿場
  • コオロギ気流感覚系におけるシナプス前後ニューロンの同時カルシウムイメージング  [Not invited]
    小川宏人, 岡浩太郎
    日本比較生理生化学会第27回大会  2005/08  調布
  • イカ色素胞における神経伝達物質の役割  [Not invited]
    鈴木真美子, 北村美一郎, 小川宏人, 岡浩太郎
    第28回日本神経科学大会  2005/07  横浜
  • ミミズの這行セントラルパターンジェネレータの探索  [Not invited]
    下井利修, 水谷賢史, 北村美一郎, 小川宏人, 岡浩太郎
    第28回日本神経科学大会  2005/07  横浜
  • セロトニンによるアクチン細胞骨格動態の変化  [Not invited]
    本間耕平, 新野祐介, 小川宏人, 北村美一郎, 岡浩太郎
    第28回日本神経科学大会  2005/07  横浜
  • 感覚刺激時におけるシナプス前後ニューロン活動のin vivo 同時イメージング  [Not invited]
    小川宏人, 岡浩太郎
    第28回日本神経科学大会  2005/07  横浜
  • ミミズの這行セントラルパターンジェネレータの探索  [Not invited]
    下井利修, 水谷賢史, 小島大介, 北村美一郎, 小川宏人, 岡浩太郎
    日本生物物理学会第42回年会  2004/12  京都
  • PC12細胞における5-HT3受容体を介した突起伸展促進効果  [Not invited]
    本間耕平, 北村美一郎, 小川宏人, 岡浩太郎
    日本生物物理学会第42回年会  2004/12  京都
  • コオロギ気流感覚系における刺激方向感受性の空間的表現と介在ニューロンによる情報抽出メカニズム  [Not invited]
    小川宏人, 岡浩太郎, Miller, J.P
    日本生物物理学会第42回年会  2004/12  京都
  • Magnesium-calcium imaging revealed mitochondrial magnesium release in PC12 cells.  [Not invited]
    Kubota, T, Shindo, Y, Komatsu, H, Kitamura, Y, Ogawa, H, Suzuki, K, Oka, K
    34th Annual Meeting of Society for Neuroscience  2004/10  San Diego
  • Consolidation of long-term memory in earthworms requires new RNA and protein synthesis.  [Not invited]
    Watanabe, H, Takaya, T, Ogawa, H, Kitamura, Y, Oka, K
    34th Annual Meeting of Society for Neuroscience  2004/10  San Diego
  • Effect of NO-cGMP signaling in non-associative learning of the earthworm, Eisenia fetida.  [Not invited]
    Kitamura, Y, Aonuma, H, Mizutani, K, Ogawa, H, Oka, K
    34th Annual Meeting of Society for Neuroscience  2004/10  San Diego
  • Comprehensive identification of motor neurons for locomotion in the earthworm by imaging method and statistical analysis.  [Not invited]
    Shimoi, T, Yokouchi, D, Mizutani, K, Kumasaka, N, Kitamura, Y, Ogawa, H, Shibata, R, Oka, K
    34th Annual Meeting of Society for Neuroscience  2004/10  San Diego
  • Searching for locomotory central pattern generator in the earthworm.  [Not invited]
    Mizutani, K, Shimoi, T, Ogawa, H, Kitamura, Y, Oka, K
    34th Annual Meeting of Society for Neuroscience  2004/10  San Diego
  • Markov analysis of foraging behavior modulated by chemical input from other individuals in Caenorhabditis elegans.  [Not invited]
    Yamanaka, T, Tanoue, H, Kitamura, Y, Ogawa, H, Oka, K
    34th Annual Meeting of Society for Neuroscience  2004/10  San Diego
  • Glutamate induced cell death distinct from excitotoxicity in PC12.  [Not invited]
    Tanaka, D, Kitamura, Y, Ogawa, H, Oka, K
    34th Annual Meeting of Society for Neuroscience  2004/10  San Diego
  • Simultaneous measurement of divalent cations in PC12 cells with a new single calcium and magnecium probe.  [Not invited]
    Shindo, Y, Kubota, T, Komatsu, H, Kitamura, Y, Ogawa, H, Suzuki, K, Oka, K
    34th Annual Meeting of Society for Neuroscience  2004/10  San Diego
  • The function of hippocampus in auditory perception revealed by in vivo optical imaging in zebra finch (Taeniopygia guttata).  [Not invited]
    Kakeue T, Kaminosato S, Kitamura Y, Ogawa H, Oka K
    34th Annual Meeting of Society for Neuroscience  2004/10  San Diego
  • Neural basis for directionally selective properties in the cricket cercal sensory system.  [Not invited]
    Ogawa H, Oka K, Miller J.P
    34th Annual Meeting of Society for Neuroscience  2004/10  San Diego
  • ミミズ非連合学習におけるNO-cGMP経路の効果  [Not invited]
    北村美一郎, 青沼仁志, 丹羽光一, 水谷賢史, 小川宏人, 岡浩太郎
    第27回日本神経科学大会  2004/09  大阪
  • NGF突起伸展時のPC12細胞におけるセロトニンの効果  [Not invited]
    本間耕平, 新野祐介, 小川宏人, 北村美一郎, 岡浩太郎
    第27回日本神経科学大会  2004/09  大阪
  • 二蛍光同時イメージングによる細胞内マグネシウム貯蔵庫の解明  [Not invited]
    久保田健, 新藤豊, 小松広和, 小川宏人, 北村美一郎, 鈴木孝治, 岡浩太郎
    第27回日本神経科学大会  2004/09  大阪
  • シナプス前後ニューロンのカルシウムイメージングが明らかにしたコオロギ気流感覚系における刺激方向抽出メカニズム  [Not invited]
    小川宏人, 岡浩太郎, Miller, J.P
    第27回日本神経科学大会  2004/09  大阪
  • Imaging analysis of representation and extraction of directional information of air-current stimuli in the cricket cercal sensory system.  [Not invited]
    Ogawa, H, Oka, K, Miller, J.P
    7th International Congress of Neuroethology  2004/08  Nyborg, Denmark
  • コオロギ気流感覚系における情報抽出および統合処理機構  [Invited]
    小川宏人
    日本比較生理生化学会第26回大会  2004/07  神戸
  • ミミズ長期記憶形成過程におけるCREB-1リン酸化とタンパク質合成  [Not invited]
    渡邉光, 高矢知宏, 小川宏人, 北村美一郎, 岡浩太郎
    日本比較生理生化学会第26回大会  2004/07  神戸
  • NO-cGMP signaling in non-associative learning of the earthworm.  [Not invited]
    Kitamura, Y, Aonuma, H, Niwa, K, Mizutani, K, Ogawa, H, Oka, K
    3rd International Conference, Biology, Chemistry, and Therapeutic Applications of Nitric Oxide  2004/05  Nara
  • Ensemble representation and integrative processing of sensory signals in the cricket cercal system.  [Invited]
    Ogawa, H
    Symposium on Invertebrate Neurobiology in REIS  2004/03  Sapporo
  • Optical imaging analysis of neural computation: internal representation and processing of sensory signals.  [Invited]
    Ogawa, H
    The 21st century COE Program at Keio, Cherry Bud Workshop "Analysis of natural and social phenomena: Data science and system reduction."  2004/03  Yokohama
  • A FRET-based approach for visualizing distribution of deformation on actin cytoskeleton.  [Not invited]
    Niino, Y, Iguchi, T, Kitamura, Y, Ogawa, H, Oka, K
    48th Annual Meeting of Biophysical Society  2004/02  Baltimore
  • Propagation of intercellular calcium waves and localization of gap junctions in endothelial cells.  [Not invited]
    Uchino, R, Kubota, T, Kitamura, Y, Ogawa, H, Oka, K
    48th Annual Meeting of Biophysical Society  2004/02  Baltimore
  • Identification of two types of synaptic activity during the earthworm fictive locomotion.  [Not invited]
    Mizutani, K, Shimoi, T, Takaya, T, Kitamura, Y, Ogawa, H, Oka, K
    33rd Annual Meeting of Society for Neuroscience  2003/11  New Orleans
  • Characterization of neurons for generating fictive locomotion in the ventral nerve cord of the earthworm, Eisenia fetida.  [Not invited]
    Shimoi, T, Mizutani, K, Takaya, T, Kitamura, Y, Ogawa, H, Oka, K
    33rd Annual Meeting of Society for Neuroscience  2003/11  New Orleans
  • Alteration of 5 - HT - induced Ca2+ increase during NGF - induced differentiation in PC12 cells.  [Not invited]
    Homma, K, Kitamura, Y, Ogawa, H, Oka, K
    33rd Annual Meeting of Society for Neuroscience  2003/11  New Orleans
  • Neural mechanism for classical conditioning in earthworm, Eisenia fetida.  [Not invited]
    Takaya, T, Watanabe, H, Kaneko, H, Shimoi, T, Mizutani, K, Ogawa, H, Kitamura, Y, Oka, K
    33rd Annual Meeting of Society for Neuroscience  2003/11  New Orleans
  • A FRET - based method for visualizing the distribution of the deformation on the actin cytoskeleton.  [Not invited]
    Niino, Y, Iguchi, T, Kitamura, Y, Ogawa, H, Oka, K
    33rd Annual Meeting of Society for Neuroscience  2003/11  New Orleans
  • Effect of NO - cGMP signaling on neural activity of the ventral nerve cord of the earthworm, Eisenia fetida.  [Not invited]
    Kitamura, Y, Hashii, H, Mizutani, K, Aonuma, H, Ogawa, H, Oka, K
    33rd Annual Meeting of Society for Neuroscience  2003/11  New Orleans
  • Populational analysis of cooperative behavior in C. elegans raised at different temperature conditions.  [Not invited]
    Tanoue, H, Mizutani, K, Kurata, S, Matsumura, H, Matsuyama, N, Ogawa, H, Kitamura, Y, Oka, K
    33rd Annual Meeting of Society for Neuroscience  2003/11  New Orleans
  • Correlation of intracellular magnesium and calcium measured by simultaneous fluorescent imaging in PC12 cells.  [Not invited]
    Kubota, T, Komatsu, H, Shindo, Y, Tokuno, K, Kitamura, Y, Ogawa, H, Suzuki, K, Oka, K
    33rd Annual Meeting of Society for Neuroscience  2003/11  New Orleans
  • Visualization of ensemble activities in cercal sensory afferents in cricket by selective leading with AM ester of calcium indicator.  [Not invited]
    Ogawa, H, Cummins, G.I, Jacobs, G.A, Miller, J.P
    33rd Annual Meeting of Society for Neuroscience  2003/11  New Orleans
  • PC12細胞内Mg動員のMg-Ca同時計測による解析  [Not invited]
    久保田健, 新藤豊, 得能健太郎, 小松広和, 小川宏人, 北村美一郎, 鈴木孝治, 岡浩太郎
    第12回日本バイオイメージング学会学術集会  2003/10  横浜
  • ミミズ這行におけるシナプス活動の可視化  [Not invited]
    水谷賢史, 下井利修, 小島大介, 高矢知宏, 北村美一郎, 小川宏人, 岡浩太郎
    第12回日本バイオイメージング学会学術集会  2003/10  横浜
  • PC12細胞におけるセロトニンによるカルシウム応答の経時変化  [Not invited]
    本間耕平, 北村美一郎, 小川宏人, 岡浩太郎
    第12回日本バイオイメージング学会学術集会  2003/10  横浜
  • ミミズ這行運動に関わるシナプス活動の2分化  [Not invited]
    水谷賢史, 下井利修, 高矢知宏, 北村美一郎, 小川宏人, 岡浩太郎
    日本生物物理学会第41回年会  2003/09  新潟
  • シマミミズ仮想這行に関わる神経細胞の機能的分類  [Not invited]
    下井利修, 水谷賢史, 高矢知宏, 北村美一郎, 小川宏人, 岡浩太郎
    日本生物物理学会第41回年会  2003/09  新潟
  • ミミズ腹髄神経系におけるNO-cGMP経路の神経活動に与える影響  [Not invited]
    北村美一郎, 橋井秀明, 水谷賢史, 青沼仁志, 小川宏人, 岡浩太郎
    日本生物物理学会第41回年会  2003/09  新潟
  • FRETを用いたアクチン細胞骨格におけるひずみ分布の測定  [Not invited]
    新野祐介, 井口崇生, 小川宏人, 北村美一郎, 岡浩太郎
    日本生物物理学会第41回年会  2003/09  新潟
  • NGF分化誘導されたPC12細胞におけるセロトニン依存性カルシウム動員の変化  [Not invited]
    本間耕平, 北村美一郎, 小川宏人, 岡浩太郎
    日本生物物理学会第41回年会  2003/09  新潟
  • 血管内皮細胞におけるCa2+伝播とギャップジャンクションとの関係に関する検討  [Not invited]
    内野怜, 久保田健, 小川宏人, 北村美一郎, 岡浩太郎
    日本生物物理学会第41回年会  2003/09  新潟
  • AM体カルシウムインジケータを用いたコオロギ気流感覚ニューロン群のアンサンブル・イメージング  [Not invited]
    小川宏人, Cummins, G.I, Jacobs, G.A, Miller, J.P
    日本生物物理学会第41回年会  2003/09  新潟
  • ミミズ這行運動に関わるシナプス活動の可視化  [Not invited]
    水谷賢史, 下井利修, 北村美一郎, 小川宏人, 岡浩太郎
    日本動物学会第74回大会  2003/09  函館
  • ミミズ神経系におけるNO-cGMP経路とその生理的作用  [Invited]
    小川宏人, 北村美一郎, 橋井秀明, 水谷賢史, 青沼仁志, 岡浩太郎
    日本動物学会第74回大会  2003/09  函館
  • カルシウムイメージング法によるコオロギ気流感覚入力の機能マッピング  [Not invited]
    小川宏人
    無脊椎動物神経研究会2003夏の学校  2003/08  箱根
  • ミミズの古典的条件付けに関わる神経回路の解析  [Not invited]
    高矢知宏, 松尾伸幸, 金子仁, 水谷賢史, 下井利修, 北村美一郎, 小川宏人, 岡浩太郎
    第26回日本神経科学大会  2003/07  名古屋
  • ミミズ(Eisenia fetida)の仮想這行に関わる神経細胞群の分類  [Not invited]
    下井利修, 水谷賢史, 松尾伸幸, 北村美一郎, 小川宏人, 岡浩太郎
    第26回日本神経科学大会  2003/07  名古屋
  • ミミズ仮想這行時のシナプス活動の可視化  [Not invited]
    水谷賢史, 下井利修, 北村美一郎, 小川宏人, 岡浩太郎
    第26回日本神経科学大会  2003/07  名古屋
  • シマミミズ腹髄神経節内の運動および感覚神経細胞の配置と投射  [Not invited]
    松尾伸幸, 北村美一郎, 小川宏人, 岡浩太郎
    第26回日本神経科学大会  2003/07  名古屋
  • 異なる温度下において条件づけされた線虫の協同的行動の解析  [Not invited]
    田上英嗣, 水谷賢史, 倉田祥子, 松村彦男, 松山奈緒, 小川宏人, 北村美一郎, 岡浩太郎
    第26回日本神経科学大会  2003/07  名古屋
  • キンカチョウ心拍に与える歌の複雑さの影響  [Not invited]
    掛上高明, 小川宏人, 北村美一郎, 岡浩太郎
    第26回日本神経科学大会  2003/07  名古屋
  • ミミズ腹髄神経節におけるNO-cGMP経路が神経活動に与える効果  [Not invited]
    北村美一郎, 橋井秀明, 水谷賢史, 青沼仁志, 小川宏人, 岡浩太郎
    第26回日本神経科学大会  2003/07  名古屋
  • PC12細胞におけるセロトニンによるカルシウム動員の解析  [Not invited]
    本間耕平, 北村美一郎, 小川宏人, 岡浩太郎
    第26回日本神経科学大会  2003/07  名古屋
  • 共焦点レーザー顕微鏡を用いた高選択的新規蛍光指示薬による細胞内Mg2+測定  [Not invited]
    久保田健, 得能健太郎, 北村美一郎, 小川宏人, 小松広和, 鈴木孝治, 岡浩太郎
    第26回日本神経科学大会  2003/07  名古屋
  • AM体カルシウムインジケータを用いたコオロギ気流感覚入力の活動パターンの可視化  [Not invited]
    小川宏人
    第26回日本神経科学大会  2003/07  名古屋
  • コオロギ気流感覚系における求心性神経終末群のカルシウムイメージング  [Not invited]
    小川宏人, Cummins, G.I, Jacobs, G.A, Miller, J.P
    日本比較生理生化学会第25回大会  2003/07  仙台
  • Analysis of serotonin-induced calcium increase in PC12 cells.  [Not invited]
    Homma, K, Kitamura, Y, Ogawa, H, Oka, K
    6th IBRO World Congress of Neuroscience  2003/07  Prague
  • Identification of two types of synaptic activity in the earthworm nervous system during fictive locomotion.  [Not invited]
    Mizutani, K, Shimoi, T, Takaya, T, Kitamura, Y, Ogawa, H, Oka, K
    6th IBRO World Congress of Neuroscience  2003/07  Prague
  • Optical monitoring pre- and postsynaptic calcium dynamics in cricket cercal sensory system.  [Not invited]
    Ogawa, H, Cummins, G.I, Jacobs, G.A, Miller, J.P
    6th IBRO World Congress of Neuroscience  2003/07  Prague
  • 無脊椎動物神経系におけるNO-cGMP経路の神経活動に与える効果  [Not invited]
    北村美一郎, 橋井秀明, 水谷賢史, 青沼仁志, 小川宏人, 岡浩太郎
    第3回日本NO学会学術集会  2003/05  熊本
  • シマミミズ古典的条件付けの分子メカニズム探索  [Not invited]
    北村美一郎, 水谷賢史, 高矢知宏, 下井利修, 松尾伸幸, 小川宏人, 岡浩太郎
    第1回貧毛類分子細胞生物研究会  2003/03  八王子
  • シマミミズ行動に伴う神経活動の解析  [Not invited]
    水谷賢史, 下井利修, 松尾伸幸, 高矢知宏, 北村美一郎, 小川宏人, 岡浩太郎
    第1回貧毛類分子細胞生物研究会  2003/03  八王子
  • Physiological role of nitric oxide production induced by tactile stimulus to the body wall of the earthworm.  [Not invited]
    Kitamura, Y, Mizutani, K, Ogawa, H, Oka, K
    32nd Annual Meeting of Society for Neuroscience  2002/11  Orlando
  • Neural cirtuits for classical conditioning in the ventral nerve cord of the earthworm (Eisenia fetida).  [Not invited]
    Matsuo, N, Shimizu, R, Ogawa, H, Kitamura, Y, Oka, K
    32nd Annual Meeting of Society for Neuroscience  2002/11  Orlando
  • Effects of 5-HT3 receptors on the mobility of growth cones in PC12 cells.  [Not invited]
    Homma, K, Kitamura, Y, Ogawa, H, Oka, K
    32nd Annual Meeting of Society for Neuroscience  2002/11  Orlando
  • Neuronal activity tracing by calcium imaging during fictive locomotion in the earthworm.  [Not invited]
    Shimoi, T, Mizutani, K, Kitamura, Y, Ogawa, H, Oka, K
    32nd Annual Meeting of Society for Neuroscience  2002/11  Orlando
  • Intracellular magnesium mobilization mechanism in PC12 cell.  [Not invited]
    Kubota, T, Kitamura, Y, Ogawa, H, Suzuki, Y, Suzuki, K, Oka, K
    32nd Annual Meeting of Society for Neuroscience  2002/11  Orlando
  • Classification of electrical activities from lateral nerves in the earthworm fictive locomotion.  [Not invited]
    Mizutani, K, Shimoi, T, Ogawa, H, Oka, K
    32nd Annual Meeting of Society for Neuroscience  2002/11  Orlando
  • Population behavioral analysis of C. elegans during chemotaxis to chloride ion.  [Not invited]
    Kurata, S, Kitamura, Y, Ogawa, H, Oka, K
    32nd Annual Meeting of Society for Neuroscience  2002/11  Orlando
  • Membrane properties of cricket cercal interneurons: Conclusions from parameter optimization in compartmental models.  [Not invited]
    Cummins, G.I, Ogawa, H, Miller, J.P, Jacobs, G.A
    32nd Annual Meeting of Society for Neuroscience  2002/11  Orlando
  • Input-dependent shift of spike initiation site modulates dendritic calcium responses in the cricket giant interneurons.  [Not invited]
    Ogawa, H, Baba, Y, Oka, K, Jacobs, G.A, Miller, J.P
    32nd Annual Meeting of Society for Neuroscience  2002/11  Orlando
  • 無脊椎動物神経回路におけるNO産生とその生理学的や役割  [Not invited]
    北村美一郎, 永野間祐一, 堀田悠人, 小川宏人, 岡浩太郎
    第25回日本神経科学会大会  2002/07  東京
  • ミミズ這行運動に関わる神経群活動の探索:カルシウムイメージングによる検討  [Not invited]
    下井利修, 水谷賢史, 北村美一郎, 小川宏人, 岡浩太郎
    第25回日本神経科学会大会  2002/07  東京
  • ミミズ仮想這行に伴う神経活動パターンの分類方法  [Not invited]
    水谷賢史, 小川宏人, 岡浩太郎
    第25回日本神経科学会大会  2002/07  東京
  • 線虫C. elegansの集団行動における個体間相互作用の解析  [Not invited]
    倉田祥子, 小川宏人, 北村美一郎, 岡浩太郎
    第25回日本神経科学会大会  2002/07  東京
  • PC-12細胞内マグネシウム動員経路の解析  [Not invited]
    久保田健, 北村美一郎, 小川宏人, 鈴木祥夫, 鈴木孝治, 岡浩太郎
    第25回日本神経科学会大会  2002/07  東京
  • PC-12細胞における成長円錐の運動性とセロトニン作動性イオンチャネル型受容体との関係  [Not invited]
    本間耕平, 北村美一郎, 小川宏人, 岡浩太郎
    第25回日本神経科学会大会  2002/07  東京
  • ミミズ反射回路におけるNO産生とその生理的役割  [Not invited]
    北村美一郎, 水谷賢史, 永野間祐一, 堀田悠人, 小川宏人, 岡浩太郎
    第25回日本神経科学会大会  2002/07  東京
  • Neural Activity Change in Earthworm by in vitro Conditioning.  [Not invited]
    Kaneko, H, Shimizu, R, Takaya T, Ogawa, H, Oka, K
    International symposium "Neuronal organization and plasticity in the microbrian system"  2001/10  Tsukuba
  • Nitric oxide production in the earthworm nervous system.  [Not invited]
    Kitamura, Y, Naganoma, Y, Horita, H, Ogawa, H, Oka, K
    International symposium "Neuronal organization and plasticity in the microbrian system"  2001/10  Tsukuba
  • Dendritic chemical computation in insect single neuron.  [Invited]
    Ogawa, H
    International symposium "Neuronal organization and plasticity in the microbrian system"  2001/10  Tsukuba
  • ミミズ筋-腹髄神経節標本におけるin vitro conditioning  [Not invited]
    小川宏人, 金子仁, 高矢知宏, 清水亮作, 岡浩太郎
    日本動物学会第72回大会  2001/10  福岡
  • ミミズ反射行動における一酸化窒素(NO)産生  [Not invited]
    北村美一郎, 永野間祐一, 堀田悠人, 小川宏人, 岡浩太郎
    日本生物物理学会第39回年会  2001/10  大阪
  • ミミズ仮想這行運動に伴う神経活動の解析  [Not invited]
    水谷賢史, 下井利修, 橋井秀明, 小川宏人, 岡浩太郎
    日本生物物理学会第39回年会  2001/10  大阪
  • ミミズのin vitro標本に対する古典的条件付けに伴う神経活動変化  [Not invited]
    金子仁, 高矢知宏, 清水亮作, 小川宏人, 岡浩太郎
    日本生物物理学会第39回年会  2001/10  大阪
  • コオロギgiant interneuron樹状突起部カルシウム応答と膜電位応答の気流刺激方向感受性  [Not invited]
    小川宏人, 馬場欣哉, 岡浩太郎
    日本生物物理学会第39回年会  2001/10  大阪
  • ミミズ腹髄神経節におけるセロトニン誘発性NO産生  [Not invited]
    北村美一郎, 永野間祐一, 堀田悠人, 小川宏人, 岡浩太郎
    第24回日本神経科学,第44回日本神経化学会合同大会  2001/09  京都
  • 新規な特異的蛍光インジケーターを用いたPC12細胞内Mg2+動員機構解析  [Not invited]
    久保田健, 中川潤, 北村美一郎, 小川宏人, 鈴木祥夫, 鈴木孝治, 岡浩太郎
    第24回日本神経科学,第44回日本神経化学会合同大会  2001/09  京都
  • ミミズ這行運動に関わるモーターパターンの解析  [Not invited]
    水谷賢史, 小川宏人, 斎藤淳一, 岡浩太郎
    第24回日本神経科学,第44回日本神経化学会合同大会  2001/09  京都
  • タップ刺激に対する線虫後退反応の「慣れ」─蛍光色素FM1-43を用いた可視化  [Not invited]
    倉田祥子, 小川宏人, 川村清, 岡浩太郎
    第24回日本神経科学,第44回日本神経化学会合同大会  2001/09  京都
  • ミミズのin vitro標本における古典的条件付け時の神経活動変化  [Not invited]
    金子仁, 高矢知宏, 清水亮作, 小川宏人, 岡浩太郎
    第24回日本神経科学,第44回日本神経化学会合同大会  2001/09  京都
  • In vivo imagingによるコオロギ巨大介在ニューロン樹状突起におけるカルシウム応答と活動電位伝搬動態の解析  [Not invited]
    小川宏人, 馬場欣哉, 岡浩太郎
    第24回日本神経科学,第44回日本神経化学会合同大会  2001/09  京都
  • ミミズ這行運動に関わるモーターパターンの解析  [Not invited]
    水谷賢史, 小川宏人, 斎藤淳一, 岡浩太郎
    無脊椎動物神経研究会2001夏の学校  2001/09  山中湖
  • タップ刺激に対する線虫後退反応の「慣れ」?蛍光色素FM1-43を用いた可視化?  [Not invited]
    倉田祥子, 小川宏人, 川村清, 岡浩太郎
    無脊椎動物神経研究会2001夏の学校  2001/09  山中湖
  • ミミズ反射行動における一酸化窒素(NO)産生機構の解明  [Not invited]
    北村美一郎, 永野間祐一, 堀田悠人, 小川宏人, 岡浩太郎
    無脊椎動物神経研究会2001夏の学校  2001/09  山中湖
  • ミミズ(Eisenia fetida)腹髄神経節内ニューロンの同定  [Not invited]
    松尾伸幸, 金子仁, 小川宏人, 岡浩太郎
    無脊椎動物神経研究会2001夏の学校  2001/09  山中湖
  • コオロギ巨大介在ニューロン樹状突起の局所カルシウム応答における方向感受性と活動電位伝搬動態の関係  [Not invited]
    小川宏人
    無脊椎動物神経研究会2001夏の学校  2001/09  山中湖
  • Neural Activity Change in Earthworm by in vitro Conditioning.  [Not invited]
    Kaneko, H, Shimizu, R, Takaya, T, Ogawa, H, Oka, K
    4th International Conference on Biological Physics  2001/07  Kyoto
  • Analysis of motor patterns for earthworm crawling behavior.  [Not invited]
    Mizutani, K, Hashii, H, Ogawa, H, Oka, K
    6th International Congress of Neuroethology  2001/07  Bonn
  • Dendritic calcium transients induced by combination of backpropagating spikes and synaptic activation in the cricket giant interneuron.  [Not invited]
    Ogawa, H, Baba, Y, Oka, K
    6th International Congress of Neuroethology  2001/07  Bonn
  • Measurement of intracellular magnesium concentration with a novel fluorescent indicator.  [Not invited]
    Kubota, T, Nakagawa, J, Kitamura, Y, Ogawa, H, Suzuki, Y, Suzuki, K, Oka, K
    4th International Conference on Biological Physics  2001/07  Kyoto
  • Visualization of Neural Activity during the Tap-withdrawal Response in C. elegans with a Fluorescent Dye,  [Not invited]
    Kurata, S, Fukada, M, Ogawa, H, Oka, K
    4th International Conference on Biological Physics  2001/07  Kyoto
  • Identification of Neurons in the Ventral Nerve Cord of the Earthworm (Eisenia foetida).  [Not invited]
    Matsuo, N, Kaneko, H, Ogawa, H, Oka, K
    4th International Conference on Biological Physics  2001/07  Kyoto
  • Serotonin-induced Nitric Oxide Production in the Earthworm Ventral Nerve Cord.  [Not invited]
    Kitamura, Y, Naganoma, Y, Horita, H, Ogawa, H, Oka, K
    4th International Conference on Biological Physics  2001/07  Kyoto
  • Information Network Analysis in Endothelial Cells by Ca2+ Signaling.  [Not invited]
    Kakegawa, M, Uchino, R, Ogawa, H, Oka, K
    4th International Conference on Biological Physics  2001/07  Kyoto
  • イメージングおよび電極法による無脊椎動物神経系からのNO放出測定  [Not invited]
    北村美一郎, 永野間祐一, 堀田悠人, 小川宏人, 岡浩太郎
    第1回日本NO学会学術集会  2001/05  福岡
  • Optical monitoring of the earthworm neural plasticity induced by classical conditioning with FM1-43.  [Not invited]
    Kaneko, H, Shimizu, R, Ogawa, H, Oka, K
    30th Annual Meeting of Society for Neuroscience  2000/11  New Orleans
  • Visualization of Neural circuits in C. elegans with a fluorescent dye, FM1-43.  [Not invited]
    Oka, K, Fukuda, M, Shimizu, R, Ogawa, H
    30th Annual Meeting of Society for Neuroscience  2000/11  New Orleans
  • Direct measurement of NO release in ventral nerve cord of the earthworm.  [Not invited]
    Horita, H, Kitamura, Y, Tsuji, N, Shimizu, R, Saito, J, Mizutani, K, Ogawa, H, Oka, K
    30th Annual Meeting of Society for Neuroscience  2000/11  New Orleans
  • Fictive locomotion induced by octopamine in the earthworm  [Not invited]
    Mizutani, K, Ogawa, H, Kitamura, Y, Saito, J, Oka, K
    30th Annual Meeting of Society for Neuroscience  2000/11  New Orleans
  • Visualization of mitochondria distribution in the earthworm median giant fiber.  [Not invited]
    Saito, J, Shimizu, R, Mizutani, K, Ogawa, H, Oka, K
    30th Annual Meeting of Society for Neuroscience  2000/11  New Orleans
  • Dendritic calcium increase induced by combination of antidromic spikes and EPSPs in the cricket giant interneurons.  [Not invited]
    Ogawa, H, Baba, Y, Oka, K
    30th Annual Meeting of Society for Neuroscience  2000/11  New Orleans
  • ヨーロッパモノアラガイの咀嚼神経回路での一酸化窒素による抑制機構  [Not invited]
    定本久世, 小林卓, 小川宏人, 伊藤悦朗
    日本動物学会第71回大会  2000/09  東京
  • 古典的条件付け後のミミズ腹髄神経節内で学習特異的に活性化されるシナプスの可視化  [Not invited]
    小川宏人, 金子仁, 清水亮作, 松尾伸幸, 岡浩太郎
    日本動物学会第71回大会  2000/09  東京
  • ミミズ巨大軸索興奮時のミトコンドリア膜電位変化  [Not invited]
    斎藤淳一, 小川宏人, 谷下一夫, 岡浩太郎
    日本生物物理学会第38回年会  2000/09  仙台
  • ミミズ腹髄神経節におけるNO作用経路のイメージング  [Not invited]
    北村美一郎, 永野間祐一, 堀田悠人, 小川宏人, 岡浩太郎
    日本生物物理学会第38回年会  2000/09  仙台
  • ミミズ這行時の神経活動解析  [Not invited]
    水谷賢史, 齋藤悠, 小川宏人, 岡浩太郎
    日本生物物理学会第38回年会  2000/09  仙台
  • 古典的条件付けによる神経可塑性部位の可視化  [Not invited]
    金子仁, 清水亮作, 小川宏人, 岡浩太郎
    日本生物物理学会第38回年会  2000/09  仙台
  • コオロギgiant interneuronにおける気流感覚情報入力部位の可視化  [Not invited]
    小川宏人, 馬場欣哉, 岡浩太郎
    日本生物物理学会第38回年会  2000/09  仙台
  • 古典的条件付けに伴うミミズ神経細胞活動の可視化  [Not invited]
    岡浩太郎, 金子仁, 松尾伸幸, 小川宏人, 清水亮作
    第23回日本神経科学,第10回日本神経回路学会合同大会  2000/09  横浜
  • ミミズ腹髄神経節でのNO産生部位とその拡散経路の可視化  [Not invited]
    北村美一郎, 永野間祐一, 堀田悠人, 小川宏人, 岡浩太郎
    第23回日本神経科学,第10回日本神経回路学会合同大会  2000/09  横浜
  • コオロギ巨大介在ニューロン樹状突起におけるEPSPと同期させた逆行性活動電位が誘導する一過性Ca2+濃度上昇  [Not invited]
    小川宏人, 馬場欣哉, 岡浩太郎
    第23回日本神経科学,第10回日本神経回路学会合同大会  2000/09  横浜
  • 神経細胞機能をイメージングする ―カルシウム・膜電位・NO・シナプス活性―  [Invited]
    小川宏人
    第4回日本比較生理生化学会若手の会シンポジウム  2000/08  山口
  • モノアラガイ中枢神経系で発生する一酸化窒素(NO)による咀嚼リズムの調節  [Not invited]
    伊藤悦朗, 小林卓, 定本久世, 小川宏人
    第11回日本比較生理生化学会大会  2000/08  山口
  • Visualization of nitric oxide production in the earthworm ventral nerve cord  [Not invited]
    Kitamura, Y, Naganoma, Y, Horita, H, Tsuji, N, Shimizu, R, Ogawa, H, Oka, K
    無脊椎動物神経研究会2000夏の学校  2000/07  山中湖
  • ミミズにおけるオクトパミン誘引性仮想這行  [Not invited]
    水谷賢史, 齋藤悠, 小川宏人, 岡浩太郎
    無脊椎動物神経研究会2000夏の学校  2000/07  山中湖
  • 神経情報伝達における軸索内ミトコンドリアの役割  [Not invited]
    斎藤淳一, 小川宏人, 岡浩太郎
    無脊椎動物神経研究会2000夏の学校  2000/07  山中湖
  • Neural plasticity of classical conditioning in earthworm  [Not invited]
    Kaneko, H, Shimizu, R, Ogawa, H, Oka, K
    無脊椎動物神経研究会2000夏の学校  2000/07  山中湖
  • Analysis of earthworm behavior with simultaneous recording of motion and extracellular field potential.  [Not invited]
    Mizutani, K, Oka, K, Ogawa, H, Suzuki, K, Shimizu, R, Saito, J, Tanishita, K
    29th Annual Meeting of Society for Neuroscience  1999/10  Miami Beach
  • Activity-dependent optical monitoring of the earthworm nervous system with FM1-43.  [Not invited]
    Shimizu, R, Oka, K, Ogawa, H, Suzuki, K, Saito, J, Mizutani, K, Tanishita, K
    29th Annual Meeting of Society for Neuroscience  1999/10  Miami Beach
  • Cellular basis for heterosynaptic depression in the cricket giant interneuron.  [Not invited]
    Ogawa, H, Baba, Y, Oka, K
    29th Annual Meeting of Society for Neuroscience  1999/10  Miami Beach
  • ミミズ腹髄神経節からのNO発生イメージング  [Not invited]
    北村美一郎, 堀田悠人, 小川宏人, 岡浩太郎, 谷下一夫
    第8回日本バイオイメージング学会学術集会  1999/10  つくば
  • 線虫逃避行動に関わる神経回路の蛍光色素FM1-43による可視化  [Not invited]
    岡浩太郎, 深田遵, 清水亮作, 小川宏人
    第8回日本バイオイメージング学会学術集会  1999/10  つくば
  • コオロギ巨大介在ニューロンにおける逆行性活動電位とシナプス入力の同時性が及ぼす細胞内Ca動態への影響  [Not invited]
    小川宏人, 馬場欣哉, 岡浩太郎
    第8回日本バイオイメージング学会学術集会  1999/10  つくば
  • 咀嚼行動発現に対するヨーロッパモノアラガイ中枢神経系でのNO測定  [Not invited]
    小林卓, 定本久世, 小川宏人, 伊藤悦朗
    日本生物物理学会第37回年会  1999/10  和光
  • ミミズ腹髄神経節内での一酸化窒素合成酵素の局在性  [Not invited]
    北村美一郎, 堀田悠人, 小川宏人, 岡浩太郎, 谷下一夫
    日本生物物理学会第37回年会  1999/10  和光
  • ミミズ這行および逃避行動時における細胞外電位測定  [Not invited]
    水谷賢史, 鈴木啓介, 清水亮作, 斎藤淳一, 北村美一郎, 小川宏人, 谷下一夫, 岡浩太郎
    日本生物物理学会第37回年会  1999/10  和光
  • ミミズ巨大軸索情報伝達におけるミトコンドリアの関与  [Not invited]
    斎藤淳一, 清水亮作, 水谷賢史, 鈴木啓介, 小川宏人, 谷下一夫, 岡浩太郎
    日本生物物理学会第37回年会  1999/10  和光
  • 光刺激に応答するミミズ腹髄神経節 内ニューロンのFM1-43による可視化  [Not invited]
    清水亮作, 金子仁, 小川宏人, 岡浩太郎
    日本生物物理学会第37回年会  1999/10  和光
  • 蛍光色素FM1-43と高速共焦点レーザ顕微鏡による線虫神経回路の可視化  [Not invited]
    岡浩太郎, 深田遵, 清水亮作, 小川宏人, 生塩研一, 守田智, 長名優子, 川村清
    日本生物物理学会第37回年会  1999/10  和光
  • コオロギgiant interneuronにおける一過性Ca上昇と逆行性活動電位-シナプス入力との同時性  [Not invited]
    小川宏人, 馬場欣哉, 岡浩太郎
    日本生物物理学会第37回年会  1999/10  和光
  • ヨーロッパモノアラガイの咀嚼神経回路でのNO測定  [Not invited]
    小林卓, 定本久世, 小川宏人, 伊藤悦朗
    日本動物学会第70回大会  1999/09  山形
  • 各種刺激で活性化されるミミズ腹髄神経節内シナプスのFM1-43による可視化  [Not invited]
    小川宏人, 清水亮作, 金子仁, 岡浩太郎
    日本動物学会第70回大会  1999/09  山形
  • Nitric oxide generation in buccal ganglia accompanying with feeding behavior in the pond snail, Lymnaea stagnalis.  [Not invited]
    Kobayashi, S, Sadamoto, H, Ogawa, H, Ito, E
    Fifth International Congress of Comparative Physiology and Biochemistry  1999/08  Calgary
  • ヨーロッパモノアラガイ(Lymnaea stagnalis)の口球神経節で産生されるNOの測定  [Not invited]
    伊藤悦朗, 小林卓, 定本久世, 小川宏人
    Gastropoda神経研究会1999夏の学校  1999/08  山中湖
  • 体壁への機械刺激によりミミズ腹髄神経節で発生するNO濃度測定  [Not invited]
    北村美一郎, 堀田悠人, 岡浩太郎, 小川宏人, 谷下一夫
    Gastropoda神経研究会1999夏の学校  1999/08  山中湖
  • イメージング法による神経活動の計測  [Not invited]
    小川宏人
    Gastropoda神経研究会1999夏の学校  1999/08  山中湖
  • FM1-43を用いたミミズ腹髄神経節神経細胞の活動依存性染色  [Not invited]
    岡浩太郎, 清水亮作, 水谷賢史, 斎藤淳一, 鈴木啓介, 小川宏人, 谷下一夫
    第22回日本神経科学大会  1999/07  大阪
  • コオロギcercal-to-giant synapseにおけるカルシウム誘導性短期抑圧メカニズム  [Not invited]
    小川宏人, 馬場欣哉, 岡浩太郎
    第22回日本神経科学大会  1999/07  大阪
  • 昆虫神経細胞におけるケミカル・コンピュテーション  [Invited]
    小川宏人
    日本動物学会北海道支部第471回例会  1998/12  札幌
  • Modulation of action potential propagation in the earthworm giant fiber by 5-HT and dopamine.  [Not invited]
    Oka, K, Tsuji, N, Shimizu, R, Suzuki, K, Ogawa, H, Tanishita, K
    28th Annual Meeting of Society for Neuroscience  1998/11  Los Angeles
  • Scratch stimulation-induced membrane potential response in the earthworm nervous system.  [Not invited]
    Shimizu, R, Oka, K, Suzuki, K, Tsuji, N, Ogawa, H, Tanishita, K
    28th Annual Meeting of Society for Neuroscience  1998/11  Los Angeles
  • Postsynaptic Ca2+ accumulation induces short-term depression of the cercal-to-giant synapse in the cricket.  [Not invited]
    Ogawa, H, Baba, Y, Oka, K
    28th Annual Meeting of Society for Neuroscience  1998/11  Los Angeles
  • Dendritic calcium regulates synaptic plasticity in insect nervous system.  [Not invited]
    Oka, K, Baba, Y, Ogawa, H
    Fifth International Conference on Neural Information Processing  1998/10  Kitakyushu
  • 機械刺激により活性化されるミミズ腹髄神経節内シナプスの可視化  [Not invited]
    清水亮作, 岡浩太郎, 小川宏人, 鈴木啓介, 斎藤淳一, 水谷賢史, 谷下一夫
    第7回日本バイオイメージング学会学術集会  1998/10  浜松
  • 気流刺激に対するコオロギ巨大介在ニューロンの膜電位およびCa2+応答  [Not invited]
    小川宏人, 馬場欣哉, 岡浩太郎
    第7回日本バイオイメージング学会学術集会  1998/10  浜松
  • 生体内局所NO濃度測定を目的とした同軸型微小電極  [Not invited]
    北村美一郎, 鵜澤智之, 岡浩太郎, 駒井豊, 小川宏人, 瀧澤直定, 小林弘祐, 谷下一夫
    日本生物物理学会第36回年会  1998/10  福岡
  • ミミズ体壁への機械刺激により活性化されるシナプスの可視化  [Not invited]
    清水亮作, 岡浩太郎, 斎藤淳一, 鈴木啓介, 水谷賢史, 小川宏人, 谷下一夫
    日本生物物理学会第36回年会  1998/10  福岡
  • 連続機械刺激によるミミズ巨大軸索内Ca2+上昇  [Not invited]
    鈴木啓介, 清水亮作, 斎藤淳一, 水谷賢史, 岡浩太郎, 小川宏人, 谷下一夫
    日本生物物理学会第36回年会  1998/10  福岡
  • ミミズ巨大軸索での興奮電位伝播修飾  [Not invited]
    岡浩太郎, 辻範子, 清水亮作, 鈴木啓介, 小川宏人, 谷下一夫
    日本生物物理学会第36回年会  1998/10  福岡
  • コオロギgiant interneuronにおける逆行性活動電位に伴うシナプス後部のCa上昇は短期抑圧を誘導する  [Not invited]
    小川宏人, 馬場欣哉, 岡浩太郎
    日本生物物理学会第36回年会  1998/10  福岡
  • 機械刺激に対するミミズ巨大軸索応答における反応潜時修飾機構の薬理学的解析  [Not invited]
    小川宏人, 清水亮作, 辻範子, 鈴木啓介, 岡浩太郎, 谷下一夫
    日本動物学会第69回大会  1998/09  広島
  • 巨大軸索を伝播する興奮電位のセロトニンとドーパミンによる調節  [Not invited]
    岡浩太郎, 辻範子, 清水亮作, 鈴木啓介, 小川宏人, 谷下一夫
    第21回日本神経科学,第41回日本神経化学合同大会  1998/09  東京
  • コオロギ巨大介在神経シナプス後部のカルシウム上昇は気流応答性を調節する  [Not invited]
    小川宏人, 馬場欣哉, 岡浩太郎
    第21回日本神経科学,第41回日本神経化学合同大会  1998/09  東京
  • ミミズ巨大軸索における活動電位伝播速度変化および細胞内Ca2+応答  [Not invited]
    鈴木啓介, 清水亮作, 斎藤淳一, 水谷賢史, 岡浩太郎, 小川宏人, 谷下一夫
    第4回Gastropoda神経研究会  1998/09  横浜
  • ビデオ解析によるミミズ逃避行動制御機構の考察  [Not invited]
    水谷賢史, 鈴木啓介, 清水亮作, 斎藤淳一, 小川宏人, 岡浩太郎, 谷下一夫
    第4回Gastropoda神経研究会  1998/09  横浜
  • コオロギ巨大介在ニューロンにおける細胞内カルシウム動員メカニズム  [Not invited]
    小川宏人, 馬場欣哉, 岡浩太郎
    第4回Gastropoda神経研究会  1998/09  横浜
  • Dendritic calcium accumulation modulating wind-sensitivity of the cricket giant interneuron.  [Not invited]
    Ogawa, H, Baba, Y, Oka, K
    5th International Congress of Neuroethology  1998/08  San Diego
  • Calcium response by the repetitive stimulation in the giant axon of the earthworm.  [Not invited]
    Suzuki, K, Shimizu, R, Tsuji, N, Oka, K, Ogawa, H, Tanishita,K
    Third World Congress of Biomechanics  1998/08  Sapporo
  • A microcoaxial electrode for nitric oxide measurement.  [Not invited]
    Kitamura, Y, Uzawa, T, Oka, K, Komai, Y, Ogawa, H, Kobayashi, H, Takizawa, N, Tanishita, K
    Third World Congress of Biomechanics  1998/08  Sapporo
  • Membrane potential imaging in earthworm ventral nerve cord induced by electrical or tactile stimulus.  [Not invited]
    Oka, K, Suzuki, K, Inaba, T, Ogawa, H, Tanishita, K
    27th Annual Meeting of Society for Neuroscience  1997/11  New Orleans
  • Subcellular calcium accumulation mechanism in the wind-sensitive giant interneurons of the cricket.  [Not invited]
    Ogawa, H, Baba, Y, Oka, K
    27th Annual Meeting of Society for Neuroscience  1997/11  New Orleans
  • 体壁への機械刺激に対するミミズ巨大軸索の膜電位応答  [Not invited]
    清水亮作, 辻範子, 岡浩太郎, 小川宏人, 谷下一夫
    日本生物物理学会第35回年会  1997/10  京都
  • 機械刺激に伴うミミズ巨大軸索内のCa2+濃度変化  [Not invited]
    鈴木啓介, 清水亮作, 辻範子, 岡浩太郎, 小川宏人, 谷下一夫
    日本生物物理学会第35回年会  1997/10  京都
  • 接触刺激により誘発されるミミズ腹髄神経節膜電位変化の可視化  [Not invited]
    岡浩太郎, 稲葉智, 鈴木啓介, 清水亮作, 辻範子, 小川宏人, 谷下一夫
    日本生物物理学会第35回年会  1997/10  京都
  • コオロギgiant interneuronにおけるNaスパイク誘導性Ca2+上昇  [Not invited]
    小川宏人, 馬場欣哉, 岡浩太郎, 河内啓二
    日本生物物理学会第35回年会  1997/10  京都
  • 機械刺激に対するミミズ腹髄神経節内ニューロンの膜電位およびカルシウム応答  [Not invited]
    小川宏人, 鈴木啓介, 稲葉智, 清水亮作, 辻範子, 岡浩太郎, 谷下一夫, 河内啓二
    日本動物学会第68回大会  1997/10  奈良
  • Development of a new nitric oxide electrode.  [Not invited]
    Kitamura, Y, Oka, K, Komai, Y, Ogawa, H, Kobayashi, H, Takizawa, N, Tanishita, K
    Fifth International Meeting on Biology of Nitric Oxide  1997/09  Kyoto
  • Electrical and chemical signal conduction in earthworm nervous system for adaptive behavior control.  [Not invited]
    Oka, K, Suzuki, K, Inaba, T, Ogawa, H, Tanishita, K
    International Symposium on System Life  1997/07  Tokyo
  • 機械刺激時のミミズ腹髄神経節内ニューロンの膜電位イメージング  [Not invited]
    鈴木啓介, 稲葉智, 小川宏人, 岡浩太郎, 谷下一夫
    第20回日本神経科学大会  1997/07  仙台
  • In vivo preparationにおけるミミズ腹髄神経節内ニューロンの集合電位解析  [Not invited]
    清水亮作, 辻範子, 鈴木啓介, 小川宏人, 岡浩太郎, 谷下一夫
    第20回日本神経科学大会  1997/07  仙台
  • コオロギ気流応答性巨大介在ニューロンにおけるCa2+ダイナミクス  [Not invited]
    小川宏人, 馬場欣哉, 岡浩太郎
    第20回日本神経科学大会  1997/07  仙台
  • 接触および電気刺激に伴うミミズ腹髄神経節の膜電位応答  [Not invited]
    岡浩太郎, 稲葉智, 鈴木啓介, 小川宏人, 谷下一夫
    第20回日本神経科学大会  1997/07  仙台
  • コオロギ気流応答性巨大介在神経細胞に存在する電位依存性Ca2+チャネル  [Not invited]
    小川宏人, 馬場欣哉, 岡浩太郎
    第20回日本神経科学大会  1997/07  仙台
  • Mobilization mechanism of calcium in the earthworm median giant fiber.  [Not invited]
    Oka, K, Ogawa, H
    26th Annual Meeting of Society for Neuroscience  1996/11  Washington D.C.
  • Intracellular Ca2+ dynamics on dendritic processing of the wind-sensitive interneurons in the cricket.  [Not invited]
    Ogawa, H, Baba, Y, Okada, K, Oka, K
    26th Annual Meeting of Society for Neuroscience  1996/11  Washington D.C.
  • ミミズ腹髄神経節での神経細胞機能マッピング  [Not invited]
    岡浩太郎, 稲葉智, 鈴木啓介, 小川宏人, 谷下一夫
    日本生物物理学会第34回年会  1996/11  つくば
  • コオロギ気流介在ニューロンの樹状突起上における細胞内Ca2+ダイナミクス  [Not invited]
    小川宏人, 馬場欣哉, 岡浩太郎
    日本生物物理学会第34回年会  1996/11  つくば
  • 側神経束刺激時のミミズ腹髄神経節膜電位イメージング  [Not invited]
    岡浩太郎, 稲葉智, 鈴木啓介, 小川宏人, 谷下一夫
    第5回日本バイオイメージング学会学術集会  1996/10  東京
  • コオロギ気流応答性介在ニューロンのCa2+イメージング  [Not invited]
    小川宏人, 馬場欣哉, 岡浩太郎
    第5回日本バイオイメージング学会学術集会  1996/10  東京
  • in vivo 神経細胞活動の可視化 ―膜電位と細胞内カルシウム―  [Invited]
    小川宏人
    日本動物学会第67回大会ワークショップ:バイオイメージング ―新しい顕微鏡による機能と形態の可視化技術―  1996/09  札幌
  • 昆虫神経細胞内のケミカル・コンピューティング  [Invited]
    小川宏人
    ERATO Symposia '96 科学技術振興事業団創造科学技術研究報告会  1996/09  東京
  • 光学的多点計測法によるミミズ腹髄神経節内ニューロンの膜電位応答解析  [Not invited]
    小川宏人, 岡田公太郎, 岡浩太郎
    日本動物学会第67回大会  1996/09  札幌
  • Ca2+ response on dendritic site of wind-sensitive giant interneurons in the cricket.  [Not invited]
    Ogawa, H, Baba, Y, Oka, K
    12th International Biophysics Congress  1996/08  Amsterdam
  • 光学的多点計測法によるミミズ腹髄神経節電位応答解析  [Not invited]
    岡浩太郎, 稲葉智, 鈴木啓介, 岡田公太郎, 小川宏人
    第2回Gastropoda神経研究会  1996/07  神戸
  • 側神経束に電気刺激を加えた場合のミミズ巨大軸索の膜電位およびCa2+応答  [Not invited]
    小川宏人, 岡田公太郎, 岡浩太郎
    第2回Gastropoda神経研究会  1996/07  神戸
  • コオロギ気流介在神経細胞の樹状突起上におけるCa2+応答  [Not invited]
    小川宏人, 馬場欣哉, 岡浩太郎
    第19回日本神経科学大会  1996/07  神戸
  • Ca2+ wave propagation mechanism in the earthworm giant fiber.  [Not invited]
    Ogawa, H, Oka, K
    The 5th international symposium on bioelectronic and molecular electronic devices and the 6th international conference on molecular electronics and biocomputing  1995/11  Okinawa
  • Application of coupled map lattice model to Ca2+ wave propagation in the earthworm median giant fiber.  [Not invited]
    Oka, K, Ogawa, H
    The 5th international symposium on bioelectronic and molecular electronic devices and the 6th international conference on molecular electronics and biocomputing  1995/11  Okinawa
  • Glutamate receptor subtypes on the earthworm median giant fiber.  [Not invited]
    Oka, K, Ogawa, H
    25th Annual Meeting of Society for Neuroscience  1995/11  San Diego
  • ミミズ巨大軸索のグルタミン酸受容体の性質  [Not invited]
    岡浩太郎, 小川宏人
    第4回日本バイオイメージング学会学術集会  1995/10  東京
  • ミミズ巨大軸索におけるCa2+反応の時空間パターン  [Not invited]
    小川宏人, 岡浩太郎
    第4回日本バイオイメージング学会学術集会  1995/10  東京
  • ミミズ腹髄神経節の興奮性グルタミン酸レセプタ  [Not invited]
    岡浩太郎, 小川宏人
    日本生物物理学会第33回年会  1995/09  札幌
  • ミミズ巨大軸索内のカルシウム動員機構の不均一性  [Not invited]
    小川宏人, 岡浩太郎
    日本生物物理学会第33回年会  1995/09  札幌
  • ミミズ巨大軸索内におけるCa2+調節機構の不均一性  [Not invited]
    小川宏人, 岡浩太郎
    日本動物学会第66回大会  1995/09  東京
  • Glutamate receptor subtypes on the earthworm median giant fiber.  [Not invited]
    Ogawa, H, Oka, K
    4th International Congress of Neuroethology  1995/09  Cambridge
  • ミミズ神経細胞のカルシウムイメージング  [Invited]
    小川宏人
    1995バイオ・ラッド コンフォーカル セミナー  1995/08  東京
  • ミミズ軸索を伝搬するCa2+波のカップルド・マップ・ラティスによる説明  [Not invited]
    岡浩太郎, 小川宏人, 藤田省三
    日本神経回路学会第5回全国大会  1994/11  つくば
  • 興奮性アミノ酸に対するミミズ巨大軸索の電位およびCa2+応答  [Not invited]
    小川宏人, 岡浩太郎, 藤田省三
    日本動物学会第65回大会  1994/10  名古屋
  • ミミズ腹髄神経節内巨大軸索のCa濃度上昇メカニズム  [Not invited]
    小川宏人, 岡浩太郎, 藤田省三
    日本動物学会第42回関東支部大会  1994/03  東京
  • 共焦点レーザー顕微鏡を用いたミミズ腹髄神経節内巨大軸索のCaイメージング  [Not invited]
    小川宏人, 岡浩太郎, 藤田省三
    日本動物学会第64回大会  1993/11  沖縄
  • 種々の技法を用いたミミズ服髄神経節神経細胞イメージング  [Not invited]
    岡浩太郎, 小川宏人, 藤田省三
    第2回日本バイオイメージング学会学術集会  1993/10  東京
  • コオロギ産卵弁の律動運動パターンの解発と調節に関与する介在ニューロン  [Not invited]
    小川宏人, 山口恒夫
    日本動物学会第62回大会  1991/10  岡山
  • Influence of proprioceptive inputs on the generation of stinging motor patterns in the honeybee.  [Not invited]
    Ogawa, H, Yamaguchi, T
    3rd International Congress of Comparative Physiology and Biochemistry  1991/08  Tokyo
  • ミツバチの針出し反応に関与する自己受容器の応答性  [Not invited]
    小川宏人, 山口恒夫
    日本動物学会中国四国支部大会  1991/05  鳥取
  • コオロギ産卵弁の律動運動と機械感覚入力の影響  [Not invited]
    小川宏人, 斉藤光男, 山口恒夫
    第1回日本比較生理生化学会大会  1990/10  高山
  • ミツバチ針出し反応系に対するセロトニンの効果  [Not invited]
    小川宏人, 斉藤光男, 山口恒夫
    日本動物学会中国四国支部大会  1990/05  高知
  • ミツバチ針出し反応系における自己受容入力と運動パターンの形成  [Not invited]
    小川宏人, 山口恒夫
    日本動物学会第60回大会  1989/10  京都
  • ミツバチにおける針出し反応のセントラル・パターン・ジェネレーターと自己受容入力  [Not invited]
    小川宏人, 山口恒夫
    日本動物学会中国四国支部大会  1989/05  広島
  • ミツバチ針出し反応系における運動ニューロンの活動パターン  [Not invited]
    小川宏人, 山口恒夫
    第10回日本動物生理学会大会  1988/06  京都
  • ミツバチ針出し反応系における運動ニューロンの活動パターン  [Not invited]
    小川宏人, 山口恒夫
    日本動物学会中国四国支部大会  1988/05  松山
  • ミツバチ針上の機械感覚受容器と針出し反応  [Not invited]
    小川宏人, 山口恒夫
    第9回日本動物生理学会大会  1987/09  長崎
  • ミツバチ針上の機械感覚受容器と針出し反応  [Not invited]
    小川宏人, 山口恒夫
    日本動物学会中国四国支部大会  1987/05  松江

MISC

Awards & Honors

  • 2004/07 Japan Society for Comparative Physiology Yoshida Award
     Study on cercal sensory processing in insects using calcium imaging 
    受賞者: Hiroto Ogawa

Research Grants & Projects

  • 文部科学省:科学研究費補助金(新学術領域研究(計画研究))
    Date (from‐to) : 2016/07 -2021/03 
    Author : 小川宏人
  • 文部科学省:科学研究費補助金(基盤研究(C))
    Date (from‐to) : 2014/04 -2017/03 
    Author : 小川宏人
  • 文部科学省:科学研究費補助金(新学術領域研究(公募研究))
    Date (from‐to) : 2014/04 -2016/03 
    Author : 小川宏人
  • 文部科学省:科学研究費補助金(新学術領域研究(公募研究))
    Date (from‐to) : 2012/04 -2014/03 
    Author : 小川宏人
  • 実行動下動物における方向情報の脳内表現と変換機構の解明と展開
    科学技術振興機構:戦略的創造研究推進事業(さきがけ研究)
    Date (from‐to) : 2009/10 -2013/03 
    Author : 小川宏人
  • 文部科学省:科学研究費補助金(基盤研究(C))
    Date (from‐to) : 2007 -2008 
    本研究は,昆虫の行動を制御する脳・神経機能の解明に向けて,行動下にある昆虫の脳神経節の神経活動を光学的に測定することを目的とする。本年度はフタホシコオロギ脳神経節のキノコ体傘部の神経活動をカルシウムイメージングによって計測することを具体的な研究課題とした。年度前半は,これまで研究実績のある最終腹部神経節を用いて,カルシウム感受性色素の導入方法の検討を行った。その結果,多数のニューロンによる集団的な神経活動をモニタするためには,神経節のシース下にAM体色素をマイクロインジェクションする方法が最も適切であることが分かった。年度後半では以上の結果を踏まえ,脳神経節シース下にカルシウム感受性色素Oregon Green BAPTA-1 AMを注入し,その蛍光画像を観察した。キノコ体傘部は,腹部神経節に比べて神経細胞密度が高いためか,色素の浸透が十分ではなくやや蛍光が暗かった。浸透時間や注入液に加える面活性剤の濃度を調節することで改善が期待される。さらに,正立蛍光顕微鏡下にin vivoの状態でキノコ体傘部をイメージングできるプレパレーションを作成し,触角にバニラとペパーミントの匂い刺激をそれぞれ与えたときのキノコ体のカルシウムイメージングを試みた。しかし,どちらの刺激でもカルシウム応答は誘導されなかった。次に,同じプレパレーションにおいて,触覚への匂い刺激と組み合わせて,小顎に10%...
  • 文部科学省:科学研究費補助金(基盤研究(C))
    Date (from‐to) : 2004 -2005 
    本研究は,コオロギの気流感覚系をモデルとして,カルシウムイメージングと電気生理を併用して,空気流方向に関する情報の抽出・統合過程を解析することを目的とした。平成16年度は,気流応答性機械感覚毛の求心性神経終末群の選択的カルシウムイメージングを行い,気流方向情報が神経終末群の活動の空間パターンで表現されていることを明らかにした。さらに応答画像の平均化・フィルタリング処理等を行って,刺激方向毎に求心性神経終末の興奮領域を特定し,機械感覚ニューロンの神経節内での活動パターンマップを作成した。平成17年度は,求心性神経終末と巨大介在ニューロン(GI)のカルシウム応答の同時イメージングを行い,GIの樹状突起の局所的活動の応答特性がその部位にシナプスしていると思われる求心性神経の応答特性を反映しているかどうかを調べた。さらに,樹状突起の分枝パターンと方向感受性が異なる10-2と10-3の2つのGIについて,機械感覚ニューロンからの気流方向情報の抽出アルゴリズムを比較した。その結果,10-3が各樹状突起分枝に局所的に入力する求心性神経の方向感受特性を抽出しているのに対し,10-2では樹上突起全体で神経節内全域の活動パターンとして表現されている情報を抽出していることがわかった。10-3では活動電位発生箇所(Spike-initiation zone : SIZ)から各樹状突起までの距離が異な...
  • 文部科学省:科学研究費補助金(特定領域研究(A))
    Date (from‐to) : 2000 -2001 
    昆虫単一細胞内の局所的演算機能を明らかにするために、コオロギ気流応答性巨大介在ニューロン(giant interneuron : GI)の樹状突起部での細胞内電位記録と高速Caイメージングの同時記録を行い、活動電位の波形とCa応答パターンの関係を調べた。GIの上向性軸索への逆行性刺激によるbackpropagating spikeと、GIに興奮性入力を持つ1次感覚ニューロンへのシナプス刺激によるsynaptic spikeは、ともに一過性の細胞内Ca濃度上昇を引き起こすが、樹状突起末端での濃度上昇はsynaptic spikeによるものの方が大きかった。このときGIの活動電位波形は記録箇所によって異なり、特にCa濃度上昇に差が見られた樹状突起部から誘導されたsynaptic spikeはbackpropagating spikeよりも振幅・幅ともに大きかった。さらに、左右の1次感覚ニューロン群を別々にシナプス刺激したとき、記録箇所と同側のシナプス刺激は活動電位の振幅を増大させ、その部位でのCa上昇は増強された。以上の結果は、樹状突起末端部での活動電位波形が変化することによって、活性化される電位依存性Caチャネルの数量が影響を受けることを示唆している。 さらに活動電位の伝播動態を調べるため、GI内の異なる2カ所から活動電位の誘導(マルチサイト・レコーディング)を行ったところ、d...
  • 文部科学省:科学研究費補助金(特定領域研究(A))
    Date (from‐to) : 1999 -1999 
    コオロギの巨大介在ニューロン(giant intemeuron : GI)を材料として、単一神経細胞内活動を高速イメ一ジング法によって可視化し、細胞内の局所的演算機能を明らかにすること試みた。その結果、カルシウム濃度感受性蛍光色素Oregon green BAPTA-1とフォトダイオード・アレイおよびIntensified CCDカメラシステムを用いて、単発の活動電位に伴う一過性の細胞内カルシウム濃度上昇(Ca transient)を捉えるのに成功した。このCa transientは活動電位数と頻度に依存し、また、受容体チャネルからの流入や代謝型受容体を介した細胞内ストアからの放出によるものではなく、電位依存性チャネルからの流入によるものであることが確認された。一方、左右の尾葉神経束をそれぞれ刺激したところ、刺激する神経束によってGI樹状突起内のCa transientのamplitudeが異なった。これらの結果から、GI内Ca濃度変化がシナプス入力に依存するメカニズムについて、次の2つの可能性が示唆された。 1.GIの樹状突起内を逆伝搬する活動電位によるCa transientがシナプス入力によって増幅される。 2.GI内における活動電位発生部位/伝搬様式自身がシナプス入力によって変化する。 そこで、GI軸索への逆行性刺激とシナプス刺激で誘導されるCa transientを...

Educational Activities

Teaching Experience

  • Behavioral Control System Sciences
    開講年度 : 2018
    課程区分 : 修士課程
    開講学部 : 生命科学院
    キーワード : 行動,脳,中枢神経系,社会性,コミュニケーション,認知,神経回路,ニューロン,最初期遺伝子,感覚情報処理,運動制御,学習,進化
  • Inter-Graduate School Classes(Educational Program):Brain Science Research
    開講年度 : 2018
    課程区分 : 修士課程
    開講学部 : 大学院共通科目
    キーワード :  神経回路、生命科学、方法論
  • Inter-Graduate School Classes(General Subject):Natural and Applied Sciences
    開講年度 : 2018
    課程区分 : 修士課程
    開講学部 : 大学院共通科目
    キーワード : 細胞増殖, 細胞極性, 細胞分化, 形態形成, 遺伝子発現, 光合成, 植物免疫, 神経回路, 動物行動学, 脳科学, 生殖機構, 発生, 内分泌,ホルモン, オムニバス, 現代生命科学, 知的財産
  • Biosystems Science
    開講年度 : 2018
    課程区分 : 修士課程
    開講学部 : 生命科学院
    キーワード : 細胞増殖、細胞極性、細胞分化、形態形成、遺伝子発現、光合成、植物免疫、神経回路、動物行動学、能科学、生殖機構、発生、内分泌、ホルモン、オムニバス、現代生命科学、知的財産
  • Biology I
    開講年度 : 2018
    課程区分 : 学士課程
    開講学部 : 全学教育
    キーワード : 生体高分子,細胞の構造と機能,エネルギー代謝,細胞の成長と分裂,遺伝現象と遺伝子発現制御
  • Behavioral Neurobiology II
    開講年度 : 2018
    課程区分 : 学士課程
    開講学部 : 理学部
    キーワード : ニューロン,シナプス,神経伝達物質,セカンドメッセンジャー,キナーゼ,遺伝子発現,エピジェネティクス,行動進化,長期増強,長期抑圧,コーディング,感覚情報処理,運動制御,神経回路,大脳皮質,大脳基底核,小脳,海馬
  • Freshman Seminar
    開講年度 : 2018
    課程区分 : 学士課程
    開講学部 : 全学教育
    キーワード : 脳科学、神経科学、認知科学、心理学、生物学、医学、薬学、保健科学、先端計測
  • Laboratory Course in Behavioral Neurobiology
    開講年度 : 2018
    課程区分 : 学士課程
    開講学部 : 理学部
    キーワード : 行動、脳、中枢神経系、脊椎動物、無脊椎動物、組織化学、遺伝子発現、光学計測、社会行動、コミュニケーション
  • Cell Biology III
    開講年度 : 2018
    課程区分 : 学士課程
    開講学部 : 理学部
    キーワード : 脂質二重膜、膜タンパク、膜輸送、イオンチャンネル、膜の電気的特性、細胞内小器官、タンパク質輸送、シグナル伝達、細胞内メッセンジャー、アポトーシス


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