Dong Peixinresearchmap個人ページ

Last Updated : 2017/11/17

Basic Information

Profile

Affiliation
Faculty of Medicine
Job TitleSpecially Appointed Assistant Professor 
Degree
E-maildpx1cngmail.com
URL
Research funding number50602504

Research Keywords

Non-coding RNA, tumor cell biology, cancer stem cell, metastasis, epigenetics, invasion, cancer

Research Areas

Oncology / Tumor biology
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Oncology / Tumor biology

Academic Background

1992/10
-
1997/09
Harbin Medical University, China M.D.
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1992/10
-
1997/09
Harbin Medical University, China M.D.

Research Activities

Papers

Lentiviral CRISPR/Cas9 nickase vector mediated BIRC5 editing inhibits epithelial to mesenchymal transition in ovarian cancer cells
2017/10
Musashi-2, a novel oncoprotein promoting cervical cancer cell growth and invasion, is negatively regulated by p53-induced miR-143 and miR-107 activation
Journal of Experimental & Clinical Cancer Research 2017/10
Enhancer of Zeste homolog 2 (EZH2) induces epithelial-mesenchymal transition in endometriosis.
Zhang Q, Dong P, Liu X, Sakuragi N, Guo SW
Scientific reports 7(1) 6804 2017/07
iASPP induces EMT and cisplatin resistance in human cervical cancer through miR-20a-FBXL5/BTG3 signaling.
Xiong Y, Sun F, Dong P, Watari H, Yue J, Yu MF, Lan CY, Wang Y, Ma ZB
Journal of experimental & clinical cancer research : CR 36(1) 48 2017/04
KLF4 expression enhances the efficacy of chemotherapy drugs in ovarian cancer cells.
Wang B, Shen A, Ouyang X, Zhao G, Du Z, Huo W, Zhang T, Wang Y, Yang C, Dong P, Watari H, Pfeffer LM, Yue J
Biochemical and biophysical research communications 484(3) 486-492 2017/03
EZH2 inhibition suppresses endometrial cancer progression via miR-361/Twist axis.
Ihira K, Dong P, Xiong Y, Watari H, Konno Y, Hanley SJ, Noguchi M, Hirata N, Suizu F, Yamada T, Kudo M, Sakuragi N
Oncotarget 8(8) 13509-13520 2017/02
Enhancer of Zeste homolog 2 (EZH2) induces epithelial-mesenchymal transition in endometriosis
2017
Lentiviral CRISPR/Cas9 vector mediated miR-21 gene editing inhibits the epithelial to mesenchymal transition in ovarian cancer cells.
Huo W, Zhao G, Yin J, Ouyang X, Wang Y, Yang C, Wang B, Dong P, Wang Z, Watari H, Chaum E, Pfeffer LM, Yue J
Journal of Cancer 8(1) 57-64 2017
Suppression of iASPP-dependent aggressiveness in cervical cancer through reversal of methylation silencing of microRNA-124.
Dong P, Xiong Y, Watari H, Hanley SJ, Konno Y, Ihira K, Suzuki F, Yamada T, Kudo M, Yue J, Sakuragi N
Scientific reports 6 35480 2016/10
Challenges in breast and cervical cancer control in Japan.
Hanley SJ, Fujita H, Tamakoshi A, Dong P, Sakuragi N
The Lancet. Oncology 17(9) e372 2016/09
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Lentiviral CRISPR/Cas9 nickase vector mediated BIRC5 editing inhibits epithelial to mesenchymal transition in ovarian cancer cells
2017/10
Musashi-2, a novel oncoprotein promoting cervical cancer cell growth and invasion, is negatively regulated by p53-induced miR-143 and miR-107 activation
Journal of Experimental & Clinical Cancer Research 2017/10
Enhancer of Zeste homolog 2 (EZH2) induces epithelial-mesenchymal transition in endometriosis.
Zhang Q, Dong P, Liu X, Sakuragi N, Guo SW
Scientific reports 7(1) 6804 2017/07
iASPP induces EMT and cisplatin resistance in human cervical cancer through miR-20a-FBXL5/BTG3 signaling.
Xiong Y, Sun F, Dong P, Watari H, Yue J, Yu MF, Lan CY, Wang Y, Ma ZB
Journal of experimental & clinical cancer research : CR 36(1) 48 2017/04
KLF4 expression enhances the efficacy of chemotherapy drugs in ovarian cancer cells.
Wang B, Shen A, Ouyang X, Zhao G, Du Z, Huo W, Zhang T, Wang Y, Yang C, Dong P, Watari H, Pfeffer LM, Yue J
Biochemical and biophysical research communications 484(3) 486-492 2017/03
EZH2 inhibition suppresses endometrial cancer progression via miR-361/Twist axis.
Ihira K, Dong P, Xiong Y, Watari H, Konno Y, Hanley SJ, Noguchi M, Hirata N, Suizu F, Yamada T, Kudo M, Sakuragi N
Oncotarget 8(8) 13509-13520 2017/02
Enhancer of Zeste homolog 2 (EZH2) induces epithelial-mesenchymal transition in endometriosis
2017
Lentiviral CRISPR/Cas9 vector mediated miR-21 gene editing inhibits the epithelial to mesenchymal transition in ovarian cancer cells.
Huo W, Zhao G, Yin J, Ouyang X, Wang Y, Yang C, Wang B, Dong P, Wang Z, Watari H, Chaum E, Pfeffer LM, Yue J
Journal of Cancer 8(1) 57-64 2017
Suppression of iASPP-dependent aggressiveness in cervical cancer through reversal of methylation silencing of microRNA-124.
Dong P, Xiong Y, Watari H, Hanley SJ, Konno Y, Ihira K, Suzuki F, Yamada T, Kudo M, Yue J, Sakuragi N
Scientific reports 6 35480 2016/10
Challenges in breast and cervical cancer control in Japan.
Hanley SJ, Fujita H, Tamakoshi A, Dong P, Sakuragi N
The Lancet. Oncology 17(9) e372 2016/09
MiR-137 and miR-34a directly target Snail and inhibit EMT, invasion and sphere-forming ability of ovarian cancer cells.
Dong P, Xiong Y, Watari H, Hanley SJ, Konno Y, Ihira K, Yamada T, Kudo M, Yue J, Sakuragi N
Journal of experimental & clinical cancer research : CR 35(1) 132 2016/09
HPV self-sampling in Japanese women: A feasibility study in a population with limited experience of tampon use.
Hanley SJ, Fujita H, Yokoyama S, Kunisawa S, Tamakoshi A, Dong P, Kobayashi N, Watari H, Kudo M, Sakuragi N
Journal of medical screening 23(3) 164-170 2016/09
Reactivation of epigenetically silenced miR-124 reverses the epithelial-to-mesenchymal transition and inhibits invasion in endometrial cancer cells via the direct repression of IQGAP1 expression.
Dong P, Ihira K, Xiong Y, Watari H, Hanley SJ, Yamada T, Hosaka M, Kudo M, Yue J, Sakuragi N
Oncotarget 7(15) 20260-20270 2016/04
Applications of CRSIPR/Cas9 in Cancer Research
2016/04
MicroRNA-101 targets EZH2, MCL-1 and FOS to suppress proliferation, invasion and stem cell-like phenotype of aggressive endometrial cancer cells
Dong Peixin
Oncotarget 5(15) 2014/08
The impact of microRNA-mediated PI3K/AKT signaling on epithelial-mesenchymal transition and cancer stemness in endometrial cancer
Dong Peixin
J Transl Med 12 2014/08
MicroRNA-106b modulates epithelial-mesenchymal transition by targeting TWIST1 in invasive endometrial cancer cell lines
Dong Peixin
Mol Carcinog 53(5) 2014/05
Identification of KLF17 as a novel epithelial to mesenchymal transition inducer via direct activation of TWIST1 in endometrioid endometrial cancer
Dong Peixin
Carcinogenesis 35(4) 2014/04
Mutant p53 gain-of-function induces epithelial–mesenchymal transition through modulation of the miR-130b–ZEB1 axis
Dong Peixin
Oncogene 32(27) 3286-3295 2013/07
Emerging Therapeutic Biomarkers in Endometrial Cancer
Dong Peixin
Biomed Res Int 2013
Prognostic significance of miR-194 in endometrial cancer
Dong Peixin
Biomark Res 2013
Allopurinol attenuates oxidative stress and cardiac fibrosis in angiotensin II-induced cardiac diastolic dysfunction.
Jia N, Dong P, Ye Y, Qian C, Dai Q
Cardiovascular therapeutics 30(2) 117-123 2012/04
MicroRNA-194 inhibits epithelial to mesenchymal transition of endometrial cancer cells by targeting oncogene BMI-1
Dong Peixin
Mol Cancer 10 99 2011/08
Elevated expression of p53 gain-of-function mutation R175H in endometrial cancer cells can increase the invasive phenotypes by activation of the EGFR/PI3K/AKT pathway
Dong Peixin
Mol Cancer. 8 103 2009/11
Cardioprotective effects of granulocyte colony-stimulating factor in angiotensin II-induced cardiac remodelling.
Jia N, Dong P, Huang Q, Jin W, Zhang J, Dai Q, Liu S
Clinical and experimental pharmacology & physiology 36(3) 262-266 2009/03
Silencing of IQGAP1 by shRNA inhibits the invasion of ovarian carcinoma HO-8910PM cells in vitro
Dong Peixin
J Exp Clin Cancer Res 27 2008
p53 dominant-negative mutant R273H promotes invasion and migration of human endometrial cancer HHUA cells
Dong Peixin
Clin Exp Metastasis 24(6) 471-483 2007
Overexpression and diffuse expression pattern of IQGAP1 at invasion fronts are independent prognostic parameters in ovarian carcinomas
Dong Peixin
Cancer Lett. 243(1) 120-127 2006/11
KLF4 expression enhances the efficacy of chemotherapy drugs in ovarian cancer cells

Bibliography

Endometrial cancer
Dong Peixin
Future Science Group, London, UK 2014/04
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Endometrial cancer
Dong Peixin
Future Science Group, London, UK 2014/04

Conferences

MicroRNA-101 attenuates Twist1 expression by induction of its negative regulator miR-361-5p through an EZH2-dependent mechanism
Dong Peixin
The 67th JSOG 2015/04
Identification of KLF17 as a novel epithelial to mesenchymal transition inducer via direct activation of TWIST1 in endometrioid endometrial cancer
Dong Peixin
The FEBS EMBO 2014 Conference 2014/09
Identification of KLF17 as a novel epithelial to mesenchymal transition inducer via direct activation of TWIST1 in endometrioid endometrial cancer
Dong Peixin
The 3rd ASGO Meeting 2013/12
MicroRNA-106b modulates epithelial-mesenchymal transition by targeting TWIST1 in invasive endometrial cancer cell lines
Dong Peixin
The 12th Meeting of Molecular Targeted Therapy in Gynecologic Cancers 2013/07
Mutant p53 gain-of-function induces epithelial-mesenchymal transition through modulation of the miR-130b-ZEB1 axis
Dong Peixin
The 65th JSOG 2013/05
MicroRNA-106b modulates epithelial-mesenchymal transition by targeting TWIST1 in invasive endometrial cancer cell lines
Dong Peixin
The 25th Hokkaido Cancer Treatment Research Meeting 2013/03
Mutant p53 gain-of-function induces epithelial-mesenchymal transition through modulation of the miR-130b-ZEB1 axis
Dong Peixin
The 3rd International Cancer Epigenetics Meeting 2012/10
MicroRNA-194, a tumor suppressor microRNA that regulates epithelial to mesenchymal transition and endometrial cancer cell invasion
Dong Peixin
The 5th World Cancer Congress (WCC-2012) 2012/05
Identification of miR-194 as a key suppressor of epithelial to mesenchymal transition in endometrial cancer
Dong Peixin
The 1st World Congress of Small RNAs 2011/11
MicroRNA-194 inhibits epithelial to mesenchymal transition of endometrial cancer cells by targeting BMI-1
Dong Peixin
The 17th International Meeting of the European Society of Gynaecological Oncology (ESGO 2011) 2011/09
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MicroRNA-101 attenuates Twist1 expression by induction of its negative regulator miR-361-5p through an EZH2-dependent mechanism
Dong Peixin
The 67th JSOG 2015/04
Identification of KLF17 as a novel epithelial to mesenchymal transition inducer via direct activation of TWIST1 in endometrioid endometrial cancer
Dong Peixin
The FEBS EMBO 2014 Conference 2014/09
Identification of KLF17 as a novel epithelial to mesenchymal transition inducer via direct activation of TWIST1 in endometrioid endometrial cancer
Dong Peixin
The 3rd ASGO Meeting 2013/12
MicroRNA-106b modulates epithelial-mesenchymal transition by targeting TWIST1 in invasive endometrial cancer cell lines
Dong Peixin
The 12th Meeting of Molecular Targeted Therapy in Gynecologic Cancers 2013/07
Mutant p53 gain-of-function induces epithelial-mesenchymal transition through modulation of the miR-130b-ZEB1 axis
Dong Peixin
The 65th JSOG 2013/05
MicroRNA-106b modulates epithelial-mesenchymal transition by targeting TWIST1 in invasive endometrial cancer cell lines
Dong Peixin
The 25th Hokkaido Cancer Treatment Research Meeting 2013/03
Mutant p53 gain-of-function induces epithelial-mesenchymal transition through modulation of the miR-130b-ZEB1 axis
Dong Peixin
The 3rd International Cancer Epigenetics Meeting 2012/10
MicroRNA-194, a tumor suppressor microRNA that regulates epithelial to mesenchymal transition and endometrial cancer cell invasion
Dong Peixin
The 5th World Cancer Congress (WCC-2012) 2012/05
Identification of miR-194 as a key suppressor of epithelial to mesenchymal transition in endometrial cancer
Dong Peixin
The 1st World Congress of Small RNAs 2011/11
MicroRNA-194 inhibits epithelial to mesenchymal transition of endometrial cancer cells by targeting BMI-1
Dong Peixin
The 17th International Meeting of the European Society of Gynaecological Oncology (ESGO 2011) 2011/09
MiR-194 inhibits epithelial to mesenchymal transition of endometrial cancer cells by targeting BMI-1
Dong Peixin
The 50th Meeting of Japan Society of Gynecologic Oncology 2011/07
MicroRNA-106b suppresses epithelial to mesenchymal transition of endometrial cancer cells by targeting IQGAP1
Dong Peixin
The 10th Meeting of Molecular Targeted Therapy in Gynecologic Cancers 2011/07
Elevated expression of p53 gain-of-function mutation R175H in endometrial cancer cells can increase the invasive phenotypes by activation of the EGFR/PI3K/AKT pathway
Dong Peixin
The 13th Biennial Meeting of the International Gynecologic Cancer Society (IGCS 2010) 2010/10
p53 dominant-negative mutation R273H promotes tumor invasion in endometrial adenocarcinoma cell line HHUA
Dong Peixin
The 100th American Association for Cancer Research Annual Meeting (AACR) 2007/04
Functional analysis of p53 status and the prognostic impact of dominant-negative p53 mutation in endometrial cancer
Dong Peixin
The 57th Annual Congress of the Japan Society of Obstetrics and Gynecology (JSOG) 2005/04

Prizes

2016/02
Hokkaido University President's Award for Outstanding Research (February 3, 2016)
2012/10
The 92nd Hokkaido Medical Congress Award
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2016/02
Hokkaido University President's Award for Outstanding Research (February 3, 2016)
2012/10
The 92nd Hokkaido Medical Congress Award

Educational Activities

Classes

Basic Principles of Medicine
Year : 2015
Dissertation Research in Medical Sciences Ⅰ
Year : 2015
Dissertation Research in Medical Sciences Ⅱ
Year : 2015
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Basic Principles of Medicine
Year : 2015
Dissertation Research in Medical Sciences Ⅰ
Year : 2015
Dissertation Research in Medical Sciences Ⅱ
Year : 2015
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Basic Principles of Medicine
Year : 2014
Dissertation Research in Medical Sciences Ⅰ
Year : 2014
Dissertation Research in Medical Sciences Ⅱ
Year : 2014
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Basic Principles of Medicine
Year : 2013
Dissertation Research in Medical Sciences Ⅰ
Year : 2013
Dissertation Research in Medical Sciences Ⅱ
Year : 2013

Contribution to Society

Committee Career

2010/04
-
Today
Hokkaido Society of Obstetrics & Gynecology
2010/04
-
Today
Japan Society of Obstetrics & Gynecology
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2010/04
-
Today
Hokkaido Society of Obstetrics & Gynecology
2010/04
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Today
Japan Society of Obstetrics & Gynecology

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