Researcher Profile and Settings

Master

Affiliation (Master)

• Faculty of Medicine　Social Medicine　Social Medicine

Affiliation (Master)

• Faculty of Medicine　Social Medicine　Social Medicine

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Profile and Settings

Profile and Settings

• Name (Japanese)

  Takashi

• Name (Kana)

  Kimura

• Name

  201901009669242622

Achievement

Research Interests

• Long COVID   Epidemiology   Public Health   

Research Areas

• Life sciences / Hygiene and public health (non-laboratory)

Research Experience

• 2019/01 - Today 北海道大学大学院医学研究院 社会医学分野公衆衛生学教室 助教
• 2016/01 - 2018/12 Osaka University Graduate School of Medicine

Published Papers

• Relationship of work-related and leisure-based screen time with obesity: a cross-sectional study on adults including older adults.

  Hana Wakasa, Takashi Kimura, Takumi Hirata, Akiko Tamakoshi

  Endocrine 2024/08/31 

  PURPOSE: The relationship between screen time (ST) and obesity has been demonstrated; however, few studies have differentiated between work-related and leisure-based use in Japanese adults, including older adults. This study aimed to examine the relationship between both work-related and leisure-based ST and obesity in adults. METHODS: This cross-sectional study was based on a questionnaire survey conducted in 2018. Overall, 9947 adults were invited; 3161 participants (31.8%) returned the questionnaire. Finally, 2488 participants (597 younger men (YM), 792 younger women (YW), 542 older men (OM), 557 older women (OW)) were included. The main exposures were work-related, leisure-based, and total ST. The outcome was obesity (body mass index ≥ 25 kg/m2). Log-binomial regression analysis was used to calculate prevalence ratios (PRs) and confidence intervals (CIs) for obesity with 1-h increments of each ST. Analyses were conducted in all participants and subgroups comprising YM, YW, OM, and OW. RESULTS: Total ST was significantly associated with obesity in all participants (PR (95% CI) 1.07 (1.04-1.10), YM (1.05 (1.01-1.10)), OM (1.13 (1.05-1.22)), and OW (1.13 (1.02-1.26)). Work-related ST was significantly associated with obesity in all participants (1.08 (1.04-1.12)), YM (1.06 (1.00-1.12)), and OM (1.24 (1.08-1.42)). Leisure-based ST was significantly associated with obesity in all participants (1.09 (1.04-1.14)), YM (1.09 (1.00-1.18)), and YW (1.10 (1.01-1.20)). CONCLUSION: ST is associated with obesity in Japanese adults including older adults; particularly, work-related ST is associated with obesity in men, and leisure-based ST, in younger individuals.
• Association between oral frailty and Prevotella percentage in the oral microbiota of community-dwelling older adults who participated in the CHEER Iwamizawa project, Japan.

  Chizuru Kimura, Kazuhito Miura, Yutaka Watanabe, Haruhisa Baba, Kimiya Ozaki, Akira Hasebe, Tokiyoshi Ayabe, Kiminori Nakamura, Shinji Nakaoka, Katsuhiko Ogasawara, Teppei Suzuki, Hiroshi Saito, Takashi Kimura, Akiko Tamakoshi, Yutaka Yamazaki

  Journal of oral rehabilitation 2024/06/08 [Refereed][Not invited]
   

  BACKGROUND: Prevotella bacteria are associated with inherent diseases of the oral cavity, such as periodontal disease, and systemic diseases. Oral frailty (OF) has been associated with nursing necessity and death. However, the relationship between OF and oral microbiota has not been fully clarified. OBJECTIVE: This cross-sectional study investigated the association between OF and Prevotella percentage in the oral microbiota of community-dwelling older adults. METHODS: Oral bacteria species from saliva were identified in 208 community-dwelling older individuals aged ≥60 years in Japan. The proportion of Prevotella in the oral microbiota was classified into three tertile groups, and its relationship with each test item for OF (number of remaining teeth, masticatory performance, oral diadochokinesis, tongue pressure, difficulties eating tough foods, difficulties swallowing tea or soup, number of applicable OF judgement items, and existence of OF) was examined using ordinal logistic regression analysis. RESULTS: The Prevotella proportions were classified into lower, middle and upper groups, comprising 70, 69 and 69 participants, respectively. The three groups showed a significant relationship between the number of remaining teeth (odds ratio [OR]: 0.946, 95% confidence interval [CI]: 0.915-0.977), masticatory performance (OR: 0.897, 95% CI: 0.844-0.953), number of applicable OF judgement items (OR: 1.477, 95% CI: 1.14-1.915), and existence of OF (OR: 4.194, 95% CI: 1.519-11.576). CONCLUSION: The proportion of Prevotella in oral microbiota was high in individuals with OF. Among the older adults, the type of oral microbiota and systemic diseases may be related to the examination and management of oral function decline.
• Diabetes and gastric cancer incidence and mortality in the Asia Cohort Consortium: A pooled analysis of more than a half million participants.

  Katherine De la Torre, Minkyo Song, Sarah Krull Abe, Md Shafiur Rahman, Md Rashedul Islam, Eiko Saito, Sukhong Min, Dan Huang, Yu Chen, Prakash C Gupta, Norie Sawada, Akiko Tamakoshi, Xiao-Ou Shu, Wanqing Wen, Ritsu Sakata, Jeongseon Kim, Chisato Nagata, Hidemi Ito, Sue K Park, Myung-Hee Shin, Mangesh S Pednekar, Shoichiro Tsugane, Takashi Kimura, Yu-Tang Gao, Hui Cai, Keiko Wada, Isao Oze, Aesun Shin, Yoon-Ok Ahn, Habibul Ahsan, Paolo Boffetta, Kee Seng Chia, Keitaro Matsuo, You-Lin Qiao, Nathaniel Rothman, Wei Zheng, Manami Inoue, Daehee Kang

  Journal of diabetes 16 (6) e13561  2024/06 [Refereed][Not invited]
   

  BACKGROUND: Evidence suggests a possible link between diabetes and gastric cancer risk, but the findings remain inconclusive, with limited studies in the Asian population. We aimed to assess the impact of diabetes and diabetes duration on the development of gastric cancer overall, by anatomical and histological subtypes. METHODS: A pooled analysis was conducted using 12 prospective studies included in the Asia Cohort Consortium. Among 558 981 participants (median age 52), after a median follow-up of 14.9 years and 10.5 years, 8556 incident primary gastric cancers and 8058 gastric cancer deaths occurred, respectively. Cox proportional hazard regression models were used to estimate study-specific hazard ratios (HRs) and 95% confidence intervals (CIs) and pooled using random-effects meta-analyses. RESULTS: Diabetes was associated with an increased incidence of overall gastric cancer (HR 1.15, 95% CI 1.06-1.25). The risk association did not differ significantly by sex (women vs men: HR 1.31, 95% CI 1.07-1.60 vs 1.12, 1.01-1.23), anatomical subsites (noncardia vs cardia: 1.14, 1.02-1.28 vs 1.17, 0.77-1.78) and histological subtypes (intestinal vs diffuse: 1.22, 1.02-1.46 vs 1.00, 0.62-1.61). Gastric cancer risk increased significantly during the first decade following diabetes diagnosis (HR 4.70, 95% CI 3.77-5.86), and decreased with time (nonlinear p < .01). Positive associations between diabetes and gastric cancer mortality were observed (HR 1.15, 95% CI 1.03-1.28) but attenuated after a 2-year time lag. CONCLUSION: Diabetes was associated with an increased gastric cancer incidence regardless of sex, anatomical subsite, or subtypes of gastric cancer. The risk of gastric cancer was particularly high during the first decade following diabetes diagnosis.
• Associations of depressive symptoms and instrumental activities of daily living decline by employment or participation in social activities among younger-older Japanese in the New Integrated Suburban Seniority Investigation (NISSIN) Project

  Rika Taniguchi, Shigekazu Ukawa, Wenjing Zhao, Satoe Okabayashi, Takashi Kimura, Yifan Shan, Masahiko Ando, Kenji Wakai, Kazuyo Tsushita, Takashi Kawamura, Akiko Tamakoshi

  Archives of Gerontology and Geriatrics Plus 1 (2) 100013 - 100013 2950-3078 2024/06 [Refereed][Not invited]
  
• The Association between COVID-19-Related Discrimination and Probable Post-Traumatic Stress Disorder among Patients with COVID-19 in Sapporo, Japan.

  Isaku Kurotori, Toshiaki R Asakura, Takashi Kimura, Miyuki Hori, Mariko Hosozawa, Masayuki Saijo, Hiroyasu Iso, Akiko Tamakoshi

  Journal of epidemiology 2024/05/11 [Refereed][Not invited]
   

  BackgroundDisasters such as earthquakes, terrorism, and pandemics have triggered post-traumatic stress disorder (PTSD), and discrimination against the affected individuals has been linked to the development of PTSD. However, there is limited evidence regarding the association between discrimination against coronavirus disease 2019 (COVID-19) patients and probable PTSD in Japan.MethodsWe conducted a cross-sectional study utilizing a web-based questionnaire targeting individuals who had contracted the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Sapporo City. A total of 4247 individuals with laboratory-confirmed SARS-CoV-2 infection spanning from February 2020 to February 2022 completed the questionnaire (response rate: 15.9%). Probable PTSD was measured using the three-item Posttraumatic Diagnostic Scale. The stratified exact logistic regression was applied to calculate the odds ratios (OR) of probable PTSD for COVID-19-related discrimination with adjusted factors.ResultsThis study included 3626 patients who had a history of SARS-CoV-2 infection. Among them, 321 patients (8.9%) experienced COVID-19-related discrimination. The prevalence of probable PTSD was 19.6% (63/321) among the patients who experienced COVID-19-related discrimination, and 4.6% (152/3305) among those who had not encountered such discrimination. The adjusted OR of COVID-19-related discrimination for probable PTSD was 4.68 (95% confidence interval [95% CI], 3.36-6.53). The population attributable fraction of probable PTSD attributable to COVID-19-related discrimination among COVID-19 patients was estimated to be 23.4% (95% CI, 21.5-25.3).ConclusionThe comprehensive epidemiological survey of COVID-19 patients in Japan showed that COVID-19-related discrimination was associated with a higher prevalence of probable PTSD. Mitigating discrimination could be helpful to attenuate PTSD in future pandemics.
• Diabetes is associated with increased liver cancer incidence and mortality in adults: A report from Asia Cohort Consortium.

  Nhan Thi Ho, Sarah Krull Abe, Md Shafiur Rahman, Rashedul Islam, Eiko Saito, Prakash C Gupta, Mangesh S Pednekar, Norie Sawada, Shoichiro Tsugane, Akiko Tamakoshi, Takashi Kimura, Xiao-Ou Shu, Yu-Tang Gao, Woon-Puay Koh, Hui Cai, Wanqing Wen, Ritsu Sakata, Ichiro Tsuji, Reza Malekzadeh, Akram Pourshams, Seiki Kanemura, Jeongseon Kim, Yu Chen, Hidemi Ito, Isao Oze, Chisato Nagata, Keiko Wada, Yumi Sugawara, Sue K Park, Aesun Shin, Jian-Min Yuan, Renwei Wang, Sun-Seog Kweon, Min-Ho Shin, Hossein Poustchi, Hossein Molavi Vardanjani, Habibul Ahsan, Kee Seng Chia, Keitaro Matsuo, You-Lin Qiao, Nathaniel Rothman, Wei Zheng, Manami Inoue, Daehee Kang, Paolo Boffetta

  International journal of cancer 2024/04/25 [Refereed][Not invited]
   

  There has been growing evidence suggesting that diabetes may be associated with increased liver cancer risk. However, studies conducted in Asian countries are limited. This project considered data of 968,738 adults pooled from 20 cohort studies of Asia Cohort Consortium to examine the association between baseline diabetes and liver cancer incidence and mortality. Cox proportional hazard model and competing risk approach was used for pooled data. Two-stage meta-analysis across studies was also done. There were 839,194 subjects with valid data regarding liver cancer incidence (5654 liver cancer cases [48.29/100,000 person-years]), follow-up time and baseline diabetes (44,781 with diabetes [5.3%]). There were 747,198 subjects with valid data regarding liver cancer mortality (5020 liver cancer deaths [44.03/100,000 person-years]), follow-up time and baseline diabetes (43,243 with diabetes [5.8%]). Hazard ratio (HR) (95% confidence interval [95%CI]) of liver cancer diagnosis in those with vs. without baseline diabetes was 1.97 (1.79, 2.16) (p < .0001) after adjusting for baseline age, gender, body mass index, tobacco smoking, alcohol use, and heterogeneity across studies (n = 586,072; events = 4620). Baseline diabetes was associated with increased cumulative incidence of death due to liver cancer (adjusted HR (95%CI) = 1.97 (1.79, 2.18); p < .0001) (n = 595,193; events = 4110). A two-stage meta-analytic approach showed similar results. This paper adds important population-based evidence to current literature regarding the increased incidence and mortality of liver cancer in adults with diabetes. The analysis of data pooled from 20 studies of different Asian countries and the meta-analysis across studies with large number of subjects makes the results robust.
• Family history and gastric cancer incidence and mortality in Asia: a pooled analysis of more than half a million participants.

  Dan Huang, Minkyo Song, Sarah Krull Abe, Md Shafiur Rahman, Md Rashedul Islam, Eiko Saito, Katherine De la Torre, Norie Sawada, Akiko Tamakoshi, Xiao-Ou Shu, Hui Cai, Atsushi Hozawa, Seiki Kanemura, Jeongseon Kim, Yu Chen, Hidemi Ito, Yumi Sugawara, Sue K Park, Myung-Hee Shin, Mayo Hirabayashi, Takashi Kimura, Yu-Tang Gao, Wanqing Wen, Isao Oze, Aesun Shin, Yoon-Ok Ahn, Habibul Ahsan, Paolo Boffetta, Kee Seng Chia, Keitaro Matsuo, You-Lin Qiao, Nathaniel Rothman, Wei Zheng, Manami Inoue, Daehee Kang

  Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2024/04/22 [Refereed][Not invited]
   

  BACKGROUND: The family history of gastric cancer holds important implications for cancer surveillance and prevention, yet existing evidence predominantly comes from case-control studies. We aimed to investigate the association between family history of gastric cancer and gastric cancer risk overall and by various subtypes in Asians in a prospective study. METHODS: We included 12 prospective cohorts with 550,508 participants in the Asia Cohort Consortium. Cox proportional hazard regression was used to estimate study-specific adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between family history of gastric cancer and gastric cancer incidence and mortality, then pooled using random-effects meta-analyses. Stratified analyses were performed for the anatomical subsites and histological subtypes. RESULTS: During the mean follow-up of 15.6 years, 2258 incident gastric cancers and 5194 gastric cancer deaths occurred. The risk of incident gastric cancer was higher in individuals with a family history of gastric cancer (HR 1.44, 95% CI 1.32-1.58), similarly in males (1.44, 1.31-1.59) and females (1.45, 1.23-1.70). Family history of gastric cancer was associated with both cardia (HR 1.26, 95% CI 1.00-1.60) and non-cardia subsites (1.49, 1.35-1.65), and with intestinal- (1.48, 1.30-1.70) and diffuse-type (1.59, 1.35-1.87) gastric cancer incidence. Positive associations were also found for gastric cancer mortality (HR 1.30, 95% CI 1.19-1.41). CONCLUSIONS: In this largest prospective study to date on family history and gastric cancer, a familial background of gastric cancer increased the risk of gastric cancer in the Asian population. Targeted education, screening, and intervention in these high-risk groups may reduce the burden of gastric cancer.
• Active and passive smoking and breast cancer in Japan: a pooled analysis of nine population-based cohort studies.

  Keiko Wada, Chisato Nagata, Mai Utada, Ritsu Sakata, Takashi Kimura, Akiko Tamakoshi, Yumi Sugawara, Ichiro Tsuji, Ren Sato, Norie Sawada, Shoichiro Tsugane, Isao Oze, Hidemi Ito, Tetsuhisa Kitamura, Yuriko N Koyanagi, Yingsong Lin, Keitaro Matsuo, Sarah K Abe, Manami Inoue

  International journal of epidemiology 53 (3) 2024/04/11 [Refereed][Not invited]
   

  BACKGROUND: Epidemiological studies have shown inconsistent results regarding the link between smoking and breast cancer risk, despite the biological plausibility of a positive association. METHODS: Participants were 166 611 women from nine prospective cohort studies in Japan which launched in 1984-1994 and followed for 8-22 years. Information on smoking and secondhand smoke was obtained through self-administered baseline questionnaires. Breast cancer was defined as code C50 according to the International Classification of Diseases for Oncology, 3rd Edition or the International Classification of Diseases, 10th Revision. After adjusting for several potential confounders, relative risks for breast cancer were calculated in the individual studies according to the current or previous status of active and passive smoking using Cox regression, followed by a summary estimate of hazard ratios using random-effects meta-analyses. RESULTS: Of the 60 441 participants who reported being premenopausal and 106 170 who reported being postmenopausal at baseline, 897 and 1168 developed breast cancer during follow-up, respectively. Compared with never smokers, current smokers had a higher risk of developing breast cancer before the age of 50 years. In addition, ever smokers who started smoking at 30 years of age or younger, or who started smoking before first childbirth, had a higher risk of developing breast cancer before the age of 50 years. No association between adulthood or childhood exposure to secondhand smoke and breast cancer was observed. CONCLUSION: Smoking may increase the risk of premenopausal breast cancer, and smoking earlier in life might be especially harmful. The impact of secondhand smoke needs further investigation.
• Traditional and Social Media Usage Associated With COVID-19 Vaccine Uptake in Sapporo, Japan.

  Satoshi Sunohara, Toshiaki R Asakura, Takashi Kimura, Masayuki Saijo, Akiko Tamakoshi

  Asia-Pacific journal of public health 10105395241240952 - 10105395241240952 2024/03/30 [Refereed]
   

  This study aimed to determine the relationship between specific information source usage and uptake of the coronavirus disease 2019 (COVID-19) vaccine. We analyzed 3348 participants aged 20 to 65 years who were not diagnosed with COVID-19 in a case-control study in Sapporo, Japan. The most prevalent information source on COVID-19 was television (TV; 87.8%), followed by online news sites (74.3%), newspapers (38.7%), websites of public institutions (30.9%), and families (29.7%). Multivariate logistic regression showed that the adjusted odds ratios of incompletion of second vaccinations for users of TV and newspaper to gather COVID-19 information were 0.31 (95% confidence interval [CI] [0.21, 0.44]) and 0.32 (95% CI [0.20, 0.50]), respectively, whereas those for users of books, commercial video sites, Facebook, and "personal blog or bulletin board system" were 3.34 (95% CI [1.58, 7.06]), 2.22 (95% CI [1.44, 3.43]), 2.36 (95% CI [1.24, 4.48]), and 4.81 (95% CI [2.72, 8.48]), respectively. Social media use among older or male participants was associated with lower vaccine uptake.
• Association of female reproductive and hormonal factors with gallbladder cancer risk in Asia: A pooled analysis of the Asia Cohort Consortium.

  Aesun Shin, Sooyoung Cho, Sarah Krull Abe, Md Rashedul Islam, Md Shafiur Rahman, Eiko Saito, Sayada Zartasha Kazmi, Ryoko Katagiri, Melissa Merritt, Ji-Yeob Choi, Xiao-Ou Shu, Norie Sawada, Akiko Tamakoshi, Woon-Puay Koh, Ritsu Sakata, Atsushi Hozawa, Jeongseon Kim, Sue K Park, Sun-Seog Kweon, Wanqing Wen, Shoichiro Tsugane, Takashi Kimura, Jian-Min Yuan, Seiki Kanemura, Yumi Sugawara, Min-Ho Shin, Habibul Ahsan, Paolo Boffetta, Kee Seng Chia, Keitaro Matsuo, You-Lin Qiao, Nathaniel Rothman, Wei Zheng, Manami Inoue, Daehee Kang

  International journal of cancer 2024/03/13 [Refereed][Not invited]
   

  The female predominance of gallbladder cancer (GBC) has led to a hypothesis regarding the hormone-related aetiology of GBC. We aimed to investigate the association between female reproductive factors and GBC risk, considering birth cohorts of Asian women. We conducted a pooled analysis of 331,323 women from 12 cohorts across 4 countries (China, Japan, Korea, and Singapore) in the Asia Cohort Consortium. Cox proportional hazard models were used to estimate the hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) to assess the association between reproductive factors (age at menarche, parity, age at first delivery, breastfeeding, and age at menopause) and GBC risk. We observed that a later age at menarche was associated with an increased risk of GBC (HR 1.4, 95% CI 1.16-1.70 for 17 years and older vs. 13-14 years), especially among the cohort born in 1940 and later (HR 2.5, 95% CI 1.50-4.35). Among the cohort born before 1940, women with a later age at first delivery showed an increased risk of GBC (HR 1.56, 95% CI 1.08-2.24 for 31 years of age and older vs. 20 years of age and younger). Other reproductive factors did not show a clear association with GBC risk. Later ages at menarche and at first delivery were associated with a higher risk of GBC, and these associations varied by birth cohort.
• Relationship between the Tortuosity of the Extracranial Internal Carotid and Vertebral Arteries on Magnetic Resonance Imaging/Angiography and Vascular Risk Factors in a Japanese Population.

  Takayuki Katayama, Kae Takahashi, Osamu Yahara, Issei Matuura, Yasuyuki Fukuda, Shin-Ichi Kawasaki, Kenji Kuroda, Takashi Kimura, Jun Sawada

  Internal medicine (Tokyo, Japan) 2024/03/11 [Refereed][Not invited]
   

  Objective We aimed to investigate the relationship between tortuosity of the extracranial internal carotid artery (ICA) or vertebral artery (VA) and vascular risk factors among residents of Asahikawa, northeast Japan. Methods We retrospectively surveyed participants of "brain dock" medical brain checkups, which involved magnetic resonance imaging and angiography. We measured the tortuosity of the ICA and VA, and evaluated vascular risk factors based on medical interviews, questionnaires, and medical records. Results A total of 218 participants were enrolled in the study. ICA tortuosity (right and left) was significantly correlated with age [odds ratio (OR): 2.452, 95% confidence interval (CI): 1.695-3.548, p<0.001]. A more pronounced correlation was observed in females than in males (OR: 1.678, 95% CI: 1.004-2.807, p=0.048). VA tortuosity (right and left) was significantly correlated with age (OR: 1.786, 95% CI: 1.250-2.550, p=0.001) and smoking history (OR: 2.140, 95% CI: 1.235-3.707, p=0.007), and was more pronounced in females than in males (OR: 1.864, 95% CI: 1.107-3.137, p=0.019). Conclusion ICA tortuosity was correlated with age, while VA tortuosity was correlated with age and smoking history. ICA and VA tortuosity were more pronounced in females than in males.
• Body mass index and lung cancer risk: Pooled analysis of 10 prospective cohort studies in Japan.

  Sayo Kawai, Yingsong Lin, Hiroshi Tsuge, Hidemi Ito, Keitaro Matsuo, Keiko Wada, Chisato Nagata, Nobuhiro Narii, Tetsuhisa Kitamura, Mai Utada, Ritsu Sakata, Takashi Kimura, Akiko Tamakoshi, Yumi Sugawara, Ichiro Tsuji, Seitaro Suzuki, Norie Sawada, Shoichiro Tsugane, Tetsuya Mizoue, Isao Oze, Sarah Krull Abe, Manami Inoue

  Cancer science 2024/02/04 [Refereed][Not invited]
   

  Mounting evidence suggests that body mass index (BMI) is inversely associated with the risk of lung cancer. However, relatively few studies have explored this association in Asian people, who have a much lower prevalence of obesity than Caucasians. We pooled data from 10 prospective cohort studies involving 444,143 Japanese men and women to address the association between BMI and the risk of lung cancer. Study-specific hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated in each cohort using the Cox proportional hazards model. A meta-analysis was undertaken by combining the results from each cohort. Heterogeneity across studies was evaluated using Cochran's Q and I2 statistics. During 5,730,013 person-years of follow-up, 6454 incident lung cancer cases (4727 men and 1727 women) were identified. Baseline BMI was inversely associated with lung cancer risk in men and women combined. While leanness (BMI <18.5) was associated with a higher risk of lung cancer (HR 1.35; 95% CI, 1.16-1.57), overweight and obesity were associated with a lower risk, with HRs of 0.77 (95% CI, 0.71-0.84) and 0.69 (95% CI, 0.45-1.07), respectively. Every 5 kg/m2 increase in BMI was associated with a 21% lower risk of lung cancer (HR 0.79; 95% CI, 0.75-0.83; p < 0.0001). Our pooled analysis indicated that BMI is inversely associated with the risk of lung cancer in the Japanese population. This inverse association could be partly attributed to residual confounding by smoking, as it was more pronounced among male smokers.
• Relationship between school sports club membership and depressive symptoms among new recruits of the Japan Self-Defense Force: A longitudinal study

  Tohru Kobayashi, Shigekazu Ukawa, Takashi Kimura, Koichi Shido, Akiko Tamakoshi

  The Journal of Physical Fitness and Sports Medicine 13 (1) 1 - 7 2186-8131 2024/01/25 [Refereed][Not invited]
  
• Differential patterns of reproductive and lifestyle risk factors for breast cancer according to birth cohorts among women in China, Japan and Korea.

  Salma Nabila, Ji-Yeob Choi, Sarah Krull Abe, Md Rashedul Islam, Md Shafiur Rahman, Eiko Saito, Aesun Shin, Melissa A Merritt, Ryoko Katagiri, Xiao-Ou Shu, Norie Sawada, Akiko Tamakoshi, Ritsu Sakata, Atsushi Hozawa, Jeongseon Kim, Chisato Nagata, Sue K Park, Sun-Seog Kweon, Hui Cai, Shoichiro Tsugane, Takashi Kimura, Seiki Kanemura, Yumi Sugawara, Keiko Wada, Min-Ho Shin, Habibul Ahsan, Paolo Boffetta, Kee Seng Chia, Keitaro Matsuo, You-Lin Qiao, Nathaniel Rothman, Wei Zheng, Manami Inoue, Daehee Kang

  Breast cancer research : BCR 26 (1) 15 - 15 2024/01/22 [Refereed][Not invited]
   

  BACKGROUND: The birth cohort effect has been suggested to influence the rate of breast cancer incidence and the trends of associated reproductive and lifestyle factors. We conducted a cohort study to determine whether a differential pattern of associations exists between certain factors and breast cancer risk based on birth cohorts. METHODS: This was a cohort study using pooled data from 12 cohort studies. We analysed associations between reproductive (menarche age, menopause age, parity and age at first delivery) and lifestyle (smoking and alcohol consumption) factors and breast cancer risk. We obtained hazard ratios (HRs) with 95% confidence intervals (CIs) using the Cox proportional hazard regression analysis on the 1920s, 1930s, 1940s and 1950s birth cohorts. RESULTS: Parity was found to lower the risk of breast cancer in the older but not in the younger birth cohort, whereas lifestyle factors showed associations with breast cancer risk only among the participants born in the 1950s. In the younger birth cohort group, the effect size was lower for parous women compared to the other cohort groups (HR [95% CI] 0.86 [0.66-1.13] compared to 0.60 [0.49-0.73], 0.46 [0.38-0.56] and 0.62 [0.51-0.77]). Meanwhile, a higher effect size was found for smoking (1.45 [1.14-1.84] compared to 1.25 [0.99-1.58], 1.06 [0.85-1.32] and 0.86 [0.69-1.08]) and alcohol consumption (1.22 [1.01-1.48] compared to 1.10 [0.90-1.33], 1.15 [0.96-1.38], and 1.07 [0.91-1.26]). CONCLUSION: We observed different associations of parity, smoking and alcohol consumption with breast cancer risk across various birth cohorts.
• Association between total fat and fatty acid intake and the risk of type 2 diabetes mellitus among Japanese adults: Analysis based on the JACC study.

  Akinori Yaegashi, Takashi Kimura, Kenji Wakai, Hiroyasu Iso, Akiko Tamakoshi

  Journal of epidemiology 2023/11/18 [Refereed][Not invited]
   

  BACKGROUND: We prospectively examined the association between total fat and fatty acid intake and type 2 diabetes (T2D) among Japanese adults. METHODS: This study was conducted using data from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC). A validated food frequency questionnaire evaluated the intake of total fat and fatty acids. Diabetes was assessed using self-reported data. Multivariable logistic regression analysis was performed to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) of incident T2D across quintiles of total fat and fatty acid intake after adjusting for potential confounders. RESULTS: A total of 19,088 non-diabetic participants (age range, 40-79 years) enrolled in the JACC between 1988 and 1990 were included in this study. During the five-year study period, 494 the participants developed T2D. The OR of T2D for the highest versus lowest quintiles was 0.58 (95% CI, 0.37-0.90) for total fat, 0.78 (95% CI, 0.51-1.20) for saturated fatty acid (SFA), 0.55 (95% CI, 0.35-0.86) for monounsaturated fatty acids (MUFA), 0.61 (95% CI, 0.39-0.96) for polyunsaturated fatty acids (PUFA), 0.64 (95% CI, 0.42-0.99) for n-3 PUFA, and 0.70 (95% CI, 0.45-1.09) for n-6 PUFA. Total fat and fatty acid (except SFA and n-6 PUFA) intake were inversely associated with T2D in men. Total fat and fatty acid intake were not associated with T2D in women. CONCLUSION: Higher intakes of total fats, MUFA, PUFA, and n-3 PUFA were inversely associated with T2D among Japanese men.
• Obesity is associated with biliary tract cancer mortality and incidence: A pooled analysis of 21 cohort studies in the Asia Cohort Consortiumc.

  Isao Oze, Hidemi Ito, Yuriko N Koyanagi, Sarah Krull Abe, Md Shafiur Rahman, Md Rashedul Islam, Eiko Saito, Prakash C Gupta, Norie Sawada, Akiko Tamakoshi, Xiao-Ou Shu, Ritsu Sakata, Reza Malekzadeh, Ichiro Tsuji, Jeongseon Kim, Chisato Nagata, San-Lin You, Sue K Park, Jian-Min Yuan, Myung-Hee Shin, Sun-Seog Kweon, Mangesh S Pednekar, Shoichiro Tsugane, Takashi Kimura, Yu-Tang Gao, Hui Cai, Akram Pourshams, Yukai Lu, Seiki Kanemura, Keiko Wada, Yumi Sugawara, Chien-Jen Chen, Yu Chen, Aesun Shin, Renwei Wang, Yoon-Ok Ahn, Min-Ho Shin, Habibul Ahsan, Paolo Boffetta, Kee Seng Chia, You-Lin Qiao, Nathaniel Rothman, Wei Zheng, Manami Inoue, Daehee Kang, Keitaro Matsuo

  International journal of cancer 2023/11/15 [Refereed][Not invited]
   

  Body fatness is considered a probable risk factor for biliary tract cancer (BTC), whereas cholelithiasis is an established factor. Nevertheless, although obesity is an established risk factor for cholelithiasis, previous studies of the association of body mass index (BMI) and BTC did not take the effect of cholelithiasis fully into account. To better understand the effect of BMI on BTC, we conducted a pooled analysis using population-based cohort studies in Asians. In total, 905 530 subjects from 21 cohort studies participating in the Asia Cohort Consortium were included. BMI was categorized into four groups: underweight (<18.5 kg/m2 ); normal (18.5-22.9 kg/m2 ); overweight (23-24.9 kg/m2 ); and obese (25+ kg/m2 ). The association between BMI and BTC incidence and mortality was assessed using hazard ratios (HR) and 95% confidence intervals (CIs) by Cox regression models with shared frailty. Mediation analysis was used to decompose the association into a direct and an indirect (mediated) effect. Compared to normal BMI, high BMI was associated with BTC mortality (HR 1.19 [CI 1.02-1.38] for males, HR 1.30 [1.14-1.49] for females). Cholelithiasis had significant interaction with BMI on BTC risk. BMI was associated with BTC risk directly and through cholelithiasis in females, whereas the association was unclear in males. When cholelithiasis was present, BMI was not associated with BTC death in either males or females. BMI was associated with BTC death among females without cholelithiasis. This study suggests BMI is associated with BTC mortality in Asians. Cholelithiasis appears to contribute to the association; and moreover, obesity appears to increase BTC risk without cholelithiasis.
• Lung Cancer Risk Prediction Models for Asian Ever-Smokers.

  Jae Jeong Yang, Wanqing Wen, Hana Zahed, Wei Zheng, Qing Lan, Sarah K Abe, Md Shafiur Rahman, Md Rashedul Islam, Eiko Saito, Prakash C Gupta, Akiko Tamakoshi, Woon-Puay Koh, Yu-Tang Gao, Ritsu Sakata, Ichiro Tsuji, Reza Malekzadeh, Yumi Sugawara, Jeongseon Kim, Hidemi Ito, Chisato Nagata, San-Lin You, Sue K Park, Jian-Min Yuan, Myung-Hee Shin, Sun-Seog Kweon, Sang-Wook Yi, Mangesh S Pednekar, Takashi Kimura, Hui Cai, Yukai Lu, Arash Etemadi, Seiki Kanemura, Keiko Wada, Chien-Jen Chen, Aesun Shin, Renwei Wang, Yoon-Ok Ahn, Min-Ho Shin, Heechoul Ohrr, Mahdi Sheikh, Batel Blechter, Habibul Ahsan, Paolo Boffetta, Kee Seng Chia, Keitaro Matsuo, You-Lin Qiao, Nathaniel Rothman, Manami Inoue, Daehee Kang, Hilary A Robbins, Xiao-Ou Shu

  Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2023/11/07 [Refereed][Not invited]
   

  OBJECTIVES: Although lung cancer prediction models are widely used to support risk-based screening, their performance outside Western populations remains uncertain. This study aims to evaluate the performance of 11 existing risk prediction models in multiple Asian populations and to re-fit prediction models for Asians. METHODS: In a pooled analysis of 186,458 Asian ever-smokers from 19 prospective cohorts, we assessed calibration (expected to observed ratios, E/O) and discrimination (area under the receiver operating characteristic curves, AUCs) for each model. In addition, we developed the 'Shanghai models' to better refine risk models for Asians based on two well-characterized population-based prospective cohorts and externally validated them in other Asian cohorts. RESULTS: Among 11 models, the Lung Cancer Death Risk Assessment Tool yielded the highest AUC (AUC [95% CI]=0.71 [0.67-0.74] for lung cancer death and 0.69 [0.67-0.72] for lung cancer incidence), and the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial Model showed good calibration overall (E/O [95% CI]=1.06 [0.90-1.25]). However, these models substantially underestimated lung cancer risk among Asians who reported less than 10 smoking pack-years or stopped smoking ≥20 years ago. The Shanghai models showed marginal improvement overall in discrimination (AUC [95% CI]=0.72 [0.69-0.74] for lung cancer death and 0.70 [0.67-0.72] for lung cancer incidence) but consistently outperformed the selected Western models among low-intensity smokers and long-term quitters. CONCLUSIONS: The Shanghai models had comparable performance overall to the best existing models, but they improved much in predicting the lung cancer risk of low-intensity smokers and long-term quitters in Asia.
• Association of the age at smoking initiation and cessation on all-cause and cause-specific mortality: The Japan Collaborative Cohort Study.

  Sulaiman Haares Zuhal, Takashi Kimura, Akiko Tamakoshi

  Nagoya journal of medical science 85 (4) 691 - 712 2023/11 [Refereed][Not invited]
   

  We estimated the association between the age at smoking initiation and cessation and all-cause and cause-specific mortality among Japanese men (n = 41,711; age 40-79 years) by analyzing data from the Japan Collaborative Cohort Study for the Evaluation of Cancer Risks. From 1988 and 1990 to 2009, 13,429 all-cause deaths (cancers, n = 4999; cardiovascular diseases, n = 3682) occurred in this cohort. Fitted Cox proportional hazard models, with never smokers as the reference group, were created. Former smokers demonstrated a lower risk for all-cause and cause-specific mortality than current smokers, with a dose-dependent reduction in the risk based on smoking-initiation age. Among former smokers who quit smoking aged 50 years or more, the highest hazard ratios were detected for those who started smoking at <20 years of age (all-cause, cancer, and cardiovascular disease mortality, hazard ratio [95% confidence interval] 1.51 [1.29-1.77], 1.68 [1.27-2.23], and 1.48 [1.12-1.96], respectively). Former smokers who quit smoking at <50 years of age had negligible all-cause or cardiovascular disease mortality regardless of the smoking-initiation age, whereas the cancer mortality risk remained significantly high among those who quit smoking at 40-49 years of age. Thus, smoking cessation significantly reduces the all-cause mortality risk; however, early initiation and later cessation do not provide a huge benefit, which earlier cessation does. Therefore, all smokers should be encouraged to quit smoking earlier in life regardless of their age at smoking initiation.
• Dual decline in subjective gait speed and domain-specific cognition is associated with higher risk of incident dementia in older Japanese adults: A 15-year age-specific cohort study.

  Wen Hao, Yi-Fan Shan, Takashi Kimura, Shigekazu Ukawa, Hideki Ohira, Satoe Okabayashi, Kenji Wakai, Masahiko Ando, Akiko Tamakoshi

  Archives of gerontology and geriatrics 117 105254 - 105254 2023/10/31 [Refereed][Not invited]
   

  OBJECTIVES: Dual decline in gait speed and cognition has been found to have higher dementia risk than no decline or pure decline. However, evidence from the Asian population is lacking. Therefore, we aimed to investigate the association of dual decline from age 65 to 70 years with late-life dementia in older Japanese adults with different personal characteristics. METHODS: Data were collected from an age-specific cohort study conducted in 482 Japanese 65-year-old adults. We investigated participant demographics, medical histories, lifestyles, subjective gait speed, and cognition at both 64/65 and 70/71 years old, and confirmed dementia until age of 85 years. Cox proportion hazard models were used to estimate the risk of dementia, with adjustments for covariates, and death was treated as a competing risk. RESULTS: After a mean follow-up period of 12.5-years, 111 participants developed dementia. Older adults with dual decline are more likely to have hyperlipidemia, diabetes, and smoking habits. And we found that dual decline in gait speed and domain-specific cognition was associated with a higher risk of dementia compared with no decline in most cognitive tests, with the highest risk observed for gait speed combined with memory (sub-distribution hazard ratio:3.89, 95 %, confidence intervals: [1.68-9.01]). However, significant differences only existed in men after stratification by sex. CONCLUSIONS: A dual decline in subjective gait speed and cognition may serve as a robust predictor of dementia over a decade prior to its onset, particularly in men. These findings highlighted the importance of screening for dual decline at an early age.
• Association between dietary carbohydrate intake and risk of type 2 diabetes: a systematic review and meta-analysis of cohort studies.

  Akinori Yaegashi, Satoshi Sunohara, Takashi Kimura, Wen Hao, Takato Moriguchi, Akiko Tamakoshi

  Diabetology international 14 (4) 327 - 338 2190-1678 2023/10 [Refereed][Not invited]
   

  BACKGROUND: Previous meta-analyses have assessed the relationship between carbohydrate intake and type 2 diabetes (T2D) risk; however, they included few studies of Asian populations who have a higher carbohydrate intake and lower insulin secretory capacity than non-Asians. Since the publication of the previous meta-analyses, three further studies of Asian populations have been conducted. Based on this background, the present study aimed to perform an updated systematically examine observational studies concerning the link between dietary carbohydrate intake and T2D risk. METHODS: We conducted a systematic search for cohort studies that investigated the target association. For each analyzed study, parameter-adjusted risk ratios were used to compare the lowest and highest carbohydrate-intake groups in terms of their risk of incident T2D. The risk ratios were calculated using a random-effects model. RESULTS: Ten publications were analyzed. Overall, carbohydrate intake was found not to be associated with increased risk ratios of incident T2D (risk ratio [RR] = 1.07; 95% confidence interval [95% CI] = 0.94, 1.21; P < 0.01, I2 = 61.9%). However, studies of Asian populations reported that high carbohydrate intake is significantly associated with this risk (RR = 1.29; 95% CI 1.15, 1.45; P = 0.59, I2 = 0.0%). CONCLUSIONS: This updated meta-analysis showed that, overall, carbohydrate intake is not associated with the risk of T2D; nevertheless, a significant association exists among Asian populations. To confirm the association between dietary carbohydrate intake and T2D risk observed in this study, further evidence from long-term observational studies of Asian populations is required. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13340-023-00642-0.
• Reproductive Factors and Endometrial Cancer Risk Among Women.

  Ryoko Katagiri, Motoki Iwasaki, Sarah Krull Abe, Md Rashedul Islam, Md Shafiur Rahman, Eiko Saito, Melissa A Merritt, Ji-Yeob Choi, Aesun Shin, Norie Sawada, Akiko Tamakoshi, Woon-Puay Koh, Ritsu Sakata, Ichiro Tsuji, Jeongseon Kim, Chisato Nagata, Sue K Park, Sun-Seog Kweon, Xiao-Ou Shu, Yu-Tang Gao, Shoichiro Tsugane, Takashi Kimura, Jian-Min Yuan, Seiki Kanemura, Yukai Lu, Yumi Sugawara, Keiko Wada, Min-Ho Shin, Habibul Ahsan, Paolo Boffetta, Kee Seng Chia, Keitaro Matsuo, You-Lin Qiao, Nathaniel Rothman, Wei Zheng, Manami Inoue, Daehee Kang

  JAMA network open 6 (9) e2332296  2023/09/05 [Refereed][Not invited]
   

  IMPORTANCE: Despite evidence of an association between reproductive factors and endometrial cancer risk, prospective studies have been conducted mainly in non-Asian countries. OBJECTIVE: To assess the association between reproductive factors, such as number of deliveries, age at menarche, or menopause, and endometrial cancer risk. DESIGN, SETTING, AND PARTICIPANTS: This cohort study used pooled individual data from 13 prospective cohort studies conducted between 1963 and 2014 in the Asia Cohort Consortium. Participants were Asian women. Data analysis was conducted from September 2019 to April 2023. EXPOSURES: Reproductive factors were assessed using a questionnaire in each cohort. MAIN OUTCOMES AND MEASURES: The main outcome was time to incidence of endometrial cancer. A Cox proportional hazards model was used to calculate hazard ratios (HRs) and 95% CIs. RESULTS: A total of 1005 endometrial cancer cases were detected among 332 625 women (mean [SD] age, 54.3 [10.4] years) during a mean (SD) of 16.5 (6.4) years of follow-up. Increasing number of deliveries was associated with a decreased endometrial cancer risk in a dose-response manner (≥5 deliveries vs nulliparous [reference]: HR, 0.37; 95% CI, 0.26-0.53; P for trend < .001). Compared with menarche at younger than 13 years, menarche at 17 years or older had an HR of 0.64 (95% CI, 0.48-0.86; P for trend < .001). Late menopause (age ≥55 years) showed an HR of 2.84 (95% CI, 1.78-4.55; P for trend < .001) compared with the youngest age category for menopause (<45 years). Age at first delivery, hormone therapy, and breastfeeding were not associated with endometrial cancer risk. CONCLUSIONS AND RELEVANCE: This large pooled study of individual participant data found that late menarche, early menopause, and a higher number of deliveries were significantly associated with a lower risk of endometrial cancer. These convincing results from Asian prospective studies add to the growing body of evidence for the association between reproductive factors and endometrial cancer.
• Five-year changes of social activity and incident long-term care needs among depressed older adults: A 15-year follow up.

  Yifan Shan, Wenjing Zhao, Wen Hao, Takashi Kimura, Shigekazu Ukawa, Hideki Ohira, Takashi Kawamura, Kenji Wakai, Masahiko Ando, Akiko Tamakoshi, Chengzeng Wang

  Archives of gerontology and geriatrics 116 105163 - 105163 2023/08/20 [Refereed][Not invited]
   

  OBJECTIVES: To examine the effects of changes in individual/multiple social activities between 65 and 70 years of age on incident long-term care (LTC) needs between 70 and 80 in older adults with depressive symptoms. METHODS: Participants were recruited from the New Integrated Suburban Seniority Investigation Project, an ongoing prospective cohort study. A total of 525 older adults with depressive symptoms were included. The validated 15-item Geriatric Depression Scale was used to assess depressive symptoms. A self-report questionnaire was used to measure social activities (social-related, learning, and personal). LTC needs was defined according to Japan's Long-term Care Insurance System. A competing risk model and a Laplace regression model were used to estimate the hazard ratios of LTC needs incidence and the 25th percentile difference in LTC-needs-free survival time and their 95% confidence intervals. RESULTS: Out of 4314 person-years of mild LTC needs, 108 individuals developed it. Participants who increased their frequency of learning activities have a lower risk of developing mild LTC needs. Increasing the frequency could also prolong LTC-needs-free survival time by approximately 2.61 years. Out of 4535 person-years for severe LTC needs, 54 individuals developed it. Participants with a continuous regular frequency of learning activities had a lower risk of developing severe LTC needs. However, the association between this frequency and LTC-needs-free survival time for severe LTC needs was insignificant in the multivariable models. CONCLUSIONS: Increased frequency of learning activities reduced the risk of LTC needs among older adults with depressive symptoms and prolonged their LTC-needs-free survival time.
• Prenatal exposure to selenium, mercury, and manganese during pregnancy and allergic diseases in early childhood: The Japan Environment and Children's study.

  Junji Miyazaki, Satoyo Ikehara, Kanami Tanigawa, Takashi Kimura, Kimiko Ueda, Keiichi Ozono, Tadashi Kimura, Yayoi Kobayashi, Shin Yamazaki, Michihiro Kamijima, Tomotaka Sobue, Hiroyasu Iso

  Environment international 179 108123 - 108123 2023/08/05 [Refereed][Not invited]
   

  BACKGROUND: Prenatal exposure to metallic elements may adversely affect early childhood health. However, more evidence is needed as population-based cohort studies are currently limited. OBJECTIVES: We aimed to examine the associations between prenatal metallic (mercury, selenium, and manganese) exposure and the risk of allergic diseases in early childhood until three years of age. METHODS: The data from 94,794 mother-infant pairs, who participated in the Japan Environment and Children's study, were used in this study. Prenatal metallic element exposure was measured in maternal blood collected during mid-pregnancy. The incidence of atopic dermatitis, food allergies, asthma, and allergic rhinitis during the first three years of life was prospectively investigated using self-reports of physician-diagnosed allergies. A multivariable modified Poisson regression model was used to estimate the cumulative incidence ratio and their 95% confidence intervals of allergic diseases associated with prenatal exposure to mercury, selenium, and manganese. We further evaluated the interaction between mercury and selenium exposures in this association. RESULTS: We confirmed 26,238 cases of childhood allergic diseases: atopic dermatitis, food allergies, asthma, and allergic rhinitis in 9,715 (10.3%), 10,897 (11.5%), and 9,857 (10.4%), 4,630 (4.9%), respectively. No association was found between prenatal mercury or manganese exposure and the risk of allergic diseases. Prenatal selenium exposure was inversely associated with atopic dermatitis, food allergies, allergic rhinitis, and any allergic diseases, but not with asthma. These inverse associations were more pronounced for lower mercury exposures than for higher exposures. CONCLUSIONS: Our findings suggest that prenatal exposure to selenium may be beneficial for reducing the risk of atopic dermatitis, food allergies, allergic rhinitis, and any allergic diseases in early childhood, especially with lower prenatal mercury exposure.
• 「母親の授乳期の食事・母乳栄養成分・乳児の発育」の関連性 岩見沢母子健康調査(SMILE Iwamizawa)における産後1ヵ月時点の解析

  小松 陽介, 和田 泰明, 田畑 風華, 川上 智美, 武田 安弘, 中村 公則, 綾部 時芳, 中村 幸志, 木村 尚史, 玉腰 暁子

  DOHaD研究 (一社)日本DOHaD学会 11 (3) 30 - 30 2187-2562 2023/08
• Maternal autistic traits and antenatal pain by cross-sectional analysis of the Japan Environment and Children's Study.

  Keiko Yamada, Takashi Kimura, Meishan Cui, Eizaburo Tanaka, Yasuhiko Kubota, Satoyo Ikehara, Hiroyasu Iso

  Scientific reports 13 (1) 6068 - 6068 2023/04/13 [Refereed]
   

  The aim of cross-sectional study was to investigate whether the presence of autistic traits in pregnant women was positively associated with the prevalence and severity of antenatal pain. We analyzed 89,068 pregnant women from a Japanese national birth cohort cross-sectionally. Autistic traits were assessed using the Japanese version of the Autism-Spectrum Quotient short form (AQ-10-J). Antenatal pain was measured using the SF-8 bodily pain item (SF-8-Pain). Antenatal pain in the second to third trimester during pregnancy was categorized into three groups: without pain, mild pain, and moderate-to-severe pain. Participants were divided into eight groups by AQ-10-J score: seven consecutive scoring groups (scores 0-6), and those above the cut-off (≥ 7) for probable autistic spectrum disorders. Odds ratios (OR) for the prevalence of mild and moderate-to-severe pain were calculated for each AQ-10-J scoring group (reference: without pain group) using multinominal logistic regression analysis. Autistic traits were positively associated with mild and moderate-to-severe pain in a dose-response manner, but the association with moderate-to-severe pain was strongest. Fully-adjusted ORs (95% confidence intervals) for moderate-to-severe pain were: 1.01 (0.91-1.13) for 1 point, 1.13 (1.02-1.25) for 2 points, 1.16 (1.04-1.29) for 3 points, 1.20 (1.07-1.34) for 4 points, 1.23 (1.09-1.40) for 5 points, 1.27 (1.10-1.47) for 6 points, and 1.24 (1.05-1.46) for ≥ 7 points (AQ-10-J cut-off). We identified an association between maternal autistic traits and antenatal pain. Maternal autistic traits may need to be considered when addressing antenatal pain during healthcare for expectant mothers.
• Case-Control Study of Long COVID, Sapporo, Japan.

  Toshiaki Asakura, Takashi Kimura, Isaku Kurotori, Katabami Kenichi, Miyuki Hori, Mariko Hosogawa, Masayuki Saijo, Kaori Nakanishi, Hiroyasu Iso, Akiko Tamakoshi

  Emerging infectious diseases 29 (5) 956 - 966 2023/04/12 [Refereed]
   

  We conducted a cross-sectional survey among SARS-CoV-2-positive persons and negative controls in Sapporo, Japan, to clarify symptoms of long COVID. We collected responses from 8,018 participants, 3,694 case-patients and 3,672 controls. We calculated symptom prevalence for case-patients at 2-3, 4-6, 7-9, 10-12, and 13-18 months after illness onset. We used logistic regression, adjusted for age and sex, to estimate the odds ratio (OR) for each symptom and control reference. We calculated symptom prevalence by stratifying for disease severity, age, and sex. At 4-18 months from illness onset, ORs for anosmia, ageusia, dyspnea, alopecia, and brain fog were consistently >1, whereas ORs for common cold-like, gastrointestinal, and dermatologic symptoms were <1. Time trend ORs increased for diminished ability to concentrate, brain fog, sleep disturbance, eye symptoms, and tinnitus. Clinicians should focus on systemic, respiratory, and neuropsychiatric symptoms among long COVID patients.
• Patient characteristics and public health office factors associated with long reporting delay of COVID-19 cases in Sapporo City, Japan.

  Daichi Watanuki, Akiko Tamakoshi, Takashi Kimura, Toshiaki Asakura, Masayuki Saijo

  Journal of epidemiology 2023/04/08 [Refereed]
   

  BACKGROUND: For therapeutic efficacy, molnupiravir and nirmatrelvir-ritonavir must be started to treat patients within 5 days of disease onset to treat patients with COVID-19. However, some patients spend more than 5 days from disease onset before reporting to the Public Health Office. This study aimed to clarify the characteristics of patients with reporting delay. METHODS: This study included data from 12,399 patients with COVID-19 who reported to the Public Health Office from March 3rd, 2021 to June 30th, 2021. Patients were stratified into "linked" (n=7,814) and "unlinked" (n=4,585) cases depending on whether they were linked to other patients. A long reporting delay was defined as the difference between the onset and reporting dates of 5 days or more. Univariate and multivariate analyses were performed using log-binomial regression to identify factors related to long reporting delay, and prevalence ratios with corresponding 95% confidence intervals were calculated. RESULTS: The proportion of long reporting delay was 24.4% (1904/7814) and 29.3% (1344/4585) in linked and unlinked cases, respectively. Risks of long reporting delay among linked cases were living alone and onset on the day with a higher 7-day daily average confirmed cases or onset on weekends; whereas, risks for unlinked cases were age over 65 years, without occupation and living alone. CONCLUSION: Our results suggest the necessity to establish a Public Health Office system that is less susceptible to the rapid increase in the number of patients, promotes educational activities for people with fewer social connections, and improves access to health care.
• [Association between father's involvement with his wife/partner during pregnancy and father-to-infant bonding failure].

  Kaki Tanaka, Emiko Okada, Takumi Hirata, Takashi Kimura, Akiko Tamakoshi

  [Nihon koshu eisei zasshi] Japanese journal of public health 70 (6) 359 - 368 2023/03/10 [Refereed][Not invited]
   

  Objectives Bonding failure is lack of parental emotional relationship between a parent and their infant. This study aims to investigate the association between father's involvements with their partner during pregnancy.Methods A total of 1,957 partners of pregnant women who had visited three maternity hospitals in Sapporo from May 2016 to December 2017 were included in the study. Self-administered questionnaires were distributed to participants at 2,435 weeks gestation and at 6-8 weeks postpartum. The fathers who responded to both the questionnaires were included in the analysis. The participants' relationship with their partners during pregnancy was rated using two questions- whether they help their partner with personal care and household chores, and whether they consult with their partner. Answers for both questions were given on a scale of 0 to 4. A total score of 6-8 points was defined as a high-score group, 3-5 points as a mid-score group, and 0-2 points as a low-score group. Bonding failure was evaluated using the Japanese version of the Mother-Infant Bonding Scale (MIBS-J). The cut-off value was the score that included the top 10% with the highest degree of bonding disorder. A logistic regression was used to analyse the association between involvement with a partner during pregnancy and bonding failure. The confounding variables were father's age, household income, father's average working hours, previous pregnancy, history of abortion/a stillbirth/the death of the child, and partner's prepartum depression during pregnancy.Results 391 fathers responded to the initial questionnaire, and 86.4% of them filled out the second questionnaire up to 2 months postpartum, 10.6% up to 3 months, 2.5% up to 4 months, and 1.0% up to 5 months. Of these, 375 were included, excluding those with missing questionnaire items. 255 fathers were in the high score group of the involvement with partner during pregnancy, 48 had bonding failure, 35 had LA, and 17 had AR. The OR based on the high score group of involvement with partner during pregnancy for bonding failure was 4.81 (1.88-12.33) for mid-score group, and 6.89 (1.40-33.93) for low-score group, and for LA, 2.21 (0.97-5.04) for mid-score group, and 6.40 (1.54-26.68) for low-score group; however, AR showed no respectively significant association (trend P 0.0005, 0.0053, 0.6859).Conclusions The results suggest that a father's unfavorable involvement with his partner affects the bonding with their infant. This suggests that involvement with a partner during pregnancy is an important factor in preventing bonding failure in fathers.
• Adult height and risk of colorectal cancer: a pooled analysis of ten population-based cohort studies in Japan.

  Rachana Manandhar Shrestha, Tetsuya Mizoue, Zobida Islam, Yukino Kawakatsu, Hidemi Ito, Keiko Wada, Chisato Nagata, Ling Zha, Tetsuhisa Kitamura, Ritsu Sakata, Takashi Kimura, Yumi Sugawara, Ichiro Tsuji, Ren Sato, Norie Sawada, Shoichiro Tsugane, Yingsong Lin, Isao Oze, Sarah Krull Abe, Manami Inoue

  Journal of epidemiology 2023/02/25 [Refereed][Not invited]
   

  BACKGROUND: While tall stature has been linked to an increase in the risk of colorectal cancer (CRC), its association with cancer in the colorectum and its subsites remains unclear among Asians. METHODS: We conducted a pooled analysis of ten population-based cohort studies among adults in Japan. Each study estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for CRC incidence associated with adult height were estimated using Cox proportional hazards regression with adjustment of the same set of covariates were then pooled to estimate summary HRs incidence using random-effect models. RESULTS: We identified 9,470 CRC incidences among 390,063 participants during 5,672,930 person-years of follow-up. Men and women with tall stature had a higher risk of CRC and colon cancer. HRs (95% CI) for CRC, colon cancer, and distal colon cancer (DCC) for the highest versus lowest height categories were 1.23 (1.07-1.40), 1.22 (1.09-1.36), and 1.27 (1.08-1.49), respectively, in men and 1.21 (1.09-1.35), 1.23 (1.08-1.40), and 1.35 (1.003-1.81), respectively, in women. The association with proximal colon cancer (PCC) and rectal cancer was less evident in both sexes. CONCLUSIONS: This pooled analysis confirms the link between tall stature and a higher risk of CRC and colon cancer (especially distal colon) among the Japanese and adds evidence to support the use of adult height to identify those at a higher risk of CRC.
• Associations between Maternal Diet, Human Milk Macronutrients, and Breast-Fed Infant Growth during the First Month of Life in the SMILE Iwamizawa in Japan.

  Yosuke Komatsu, Yasuaki Wada, Fuka Tabata, Satomi Kawakami, Yasuhiro Takeda, Kiminori Nakamura, Tokiyoshi Ayabe, Koshi Nakamura, Takashi Kimura, Akiko Tamakoshi

  Nutrients 15 (3) 2023/01/28 [Refereed][Not invited]
   

  Maternal diet may affect human milk macronutrients, but it remains to be elucidated whether this is also influential in infant growth. This study aimed to examine (1) how maternal diet influences human milk macronutrients, and (2) to what extent the variation in milk macronutrients affects infant growth during the first month of life. In 71 Japanese lactating women, maternal dietary information was collected from the brief-type self-administered diet history questionnaire, and anthropometry of mother-infant dyads was collected from medical records. Macronutrients in milk were analyzed by a Human Milk Analyzer. Maternal retinol intake was associated with the carbohydrate content in human milk at 1-month postpartum (standardized β coefficient: 0.287; p = 0.038). Moreover, the energy content in human milk was associated with an increase in the weight standard deviation score based on the WHO growth standard at 1 month of age (standardized β coefficient: 0.399; p = 0.046). Nevertheless, the milk macronutrient was not associated with the risk of infant growth abnormalities. In conclusion, a part of the maternal diet impacts macronutrient contents in human milk, but milk macronutrients have a limited effect on infant growth only within the normal growth curve during the first month of life.
• Association between advanced airway management with adrenaline injection and prognosis in adult patients with asystole asphyxia out-of-hospital cardiac arrest.

  Kenichi Katabami, Takashi Kimura, Takumi Hirata, Akiko Tamakoshi

  Journal of epidemiology 2023/01/28 [Refereed][Not invited]
   

  BACKGROUND: The neurological prognosis of asphyxia is poor and the effect of advanced airway management (AAM) in the prehospital setting remains unclear. This study aimed to evaluate the association between AAM with adrenaline injection and prognosis in adult patients with asystole asphyxia out-of-hospital cardiac arrest (OHCA). METHODS: This study assessed all-Japan Utstein cohort registry data between January 1, 2013 and December 31, 2019. We used propensity score matching analyses before logistic regression analysis to evaluate the effect of AAM on favorable neurological outcome. RESULTS: There were 879,057 OHCA cases, including 70,299 cases of asphyxia OHCAs. We extracted the data of 13,642 cases provided with adrenaline injection by emergency medical service. We divided 7,945 asphyxia OHCA cases in asystole into 5,592 and 2,353 with and without AAM, respectively. After 1:1 propensity score matching, 2,338 asphyxia OHCA cases with AAM were matched with 2,338 cases without AAM. Favorable neurological outcome was not significantly different between the AAM and no AAM groups (adjusted odds ratio: 1.1, 95% confidence interval (CI): 0.5-2.5). However, the return of spontaneous circulation (ROSC) (adjusted odds ratio: 1.7, 95% CI: 1.5-1.9) and 1-month survival were improved in the AAM groups (adjusted odds ratio: 1.5, 95% CI: 1.1-1.9). CONCLUSIONS: AAM with adrenaline injection for patients with asphyxia OHCA in asystole was associated with improved ROSC and 1-month survival rate but showed no differences in neurologically favorable outcome. Further prospective studies may comprehensively evaluate the effect of AAM for patients with asphyxia.
• Relationship between out-of-facility deliveries and distance and travel time to delivery facilities in Hokkaido, Japan: An ecological study.

  Yoshihiro Saito, Toshiaki Asakura, Kimura Takashi, Takeshi Umazume, Hidemichi Watari, Akiko Tamakoshi

  The journal of obstetrics and gynaecology research 49 (3) 930 - 937 2023/01/05 [Refereed][Not invited]
   

  AIM: This study aimed to investigate the relationship between the distance and travel time from each municipality to the nearest delivery facilities in the other municipalities and the frequency of out-of-facility deliveries in Hokkaido. METHODS: Vital statistics from 2016 to 2020 were used. For municipalities without delivery facilities, the distance and travel time from the town office of each municipality to the nearest delivery facility was measured using Google maps. Negative binomial regression with an offset term was used to calculate the relative risks (RRs) and 95% confidence intervals (CIs) of out-of-facility delivery for distance (<30, 30-59, ≥60 km), and travel time by car (<30, 30-59, and ≥60 min) from the town office to the nearest delivery facility compared with the presence of delivery facilities. RESULTS: The overall rate of out-of-facility deliveries in Hokkaido was 2.1‰; in municipalities with delivery facilities, 1.8‰, and in municipalities without delivery facilities, 3.1‰. The adjusted RRs (95% CIs) for out-of-facility deliveries were significantly higher in municipalities with less than 30 km and travel time of less than 30 min to delivery facilities, 2.63 (1.34-5.17) and 2.76 (1.36-5.58), respectively, compared to municipalities with delivery facilities. However, the adjusted RR of out-of-facility delivery for municipalities ≥30 km was higher, although the difference was not significant. CONCLUSIONS: Even in municipalities with a distance to delivery facilities of less than 30 km or travel time of less than 30 min, we should keep in mind the occurrence of out-of-facility deliveries.
• Association between low-carbohydrate diet score and incidence of type 2 diabetes among Japanese adults: the JACC Study.

  Akinori Yaegashi, Takashi Kimura, Takumi Hirata, Hiroyasu Iso, Akiko Tamakoshi

  Journal of nutritional science 12 e50  2023 [Refereed][Not invited]
   

  We prospectively examined the association between low-carbohydrate diet (LCD) score and incidence of type 2 diabetes (T2D) in Japanese adults using Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study) data. A total of 19 084 (7052 men and 12 032 women) Japanese non-diabetic participants aged 40-79 years, who enrolled in the JACC study between 1988 and 1990, were included in our analysis. Dietary intake was evaluated using a validated food-frequency questionnaire. The overall, animal and vegetable LCD scores were calculated by dividing the study participants into eleven categories based on the percentages of energy from carbohydrates, protein and fat. The incidence of T2D was assessed using a self-administered questionnaire. We used multivariable logistic regression analysis to estimate the odds ratios (ORs) and 95 % confidence intervals (CIs) of incident T2D across the quintile of each LCD score, with adjustment for potential confounders. During the 5-year study period, 490 adults (247 men and 243 women) developed T2D. The multivariable-adjusted OR of incident T2D for the highest v. lowest quintiles of overall and animal LCD scores, respectively, were 0·64 (95 % CI 0·42, 0·99) and 0·83 (95 % CI 0·55, 1·27) for men, 0·78 (95 % CI 0·51, 1·18) and 0·84 (95 % CI 0·57, 1·24) for women. The vegetable LCD score was associated with a lower risk of T2D in men (OR 0·51; 95 % CI 0·33, 0·77). Our results suggest that diets lower in carbohydrates and higher in fat and protein are unlikely to higher the T2D risk among Japanese individuals.
• Paternal occupational exposures and infant congenital heart defects in the Japan Environment and Children's Study.

  Mina Hayama-Terada, Yuri Aochi, Satoyo Ikehara, Takashi Kimura, Kazumasa Yamagishi, Takuyo Sato, Hiroyasu Iso

  Environmental health and preventive medicine 28 12 - 12 2023 [Refereed][Not invited]
   

  BACKGROUND: Few prospective studies have investigated the association between paternal occupational exposures and risk of infant congenital heart defects (CHDs). We investigated the associations between paternal occupational exposures, frequency of use, and concurrent or sequential exposure to a mixture of compounds and the risk of infant CHDs. METHODS: Our study examined 28,866 participants in the Japan Environment and Children's Study. Logistic regression analysis was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) associated with paternal occupational exposures during the 3 months until pregnancy was noticed after adjustment for potential confounding factors of the infant CHDs. CHD diagnosis was ascertained from medical record. RESULTS: In total, 175 were diagnosed with infant CHDs. The number of fathers who were exposed to the following substances at least once a month were: 11,533 for photo copying machine/laser printer, 10,326 for permanent marker, 8,226 for soluble paint/inkjet printer, 6,188 for kerosene/petroleum/benzene/gasoline, 4,173 for organic solvents, 3,433 for chlorine bleach/germicide, 2,962 for engine oil, 2,931 for insecticide, 2,460 for medical sterilizing disinfectant, 1,786 for welding fumes, 1,614 for dyestuffs, 1,247 for any products containing lead-like solder, 986 for herbicide, 919 for radiation/radioactive substances/isotopes, 837 for lead-free solder, 341 for microbes, 319 for formalin/formaldehyde, 301 for agricultural chemical not listed above or unidentified, 196 for general anesthetic for surgery at hospital, 171 for anti-cancer drug, 147 for chromium/arsenic/cadmium, 88 for mercury and 833 for other chemical substances. Paternal occupational exposure regularly to photo copying machine or laser printer and soluble paint/inkjet printer were associated with higher risks of infant CHDs: the adjusted ORs (95%CIs) were 1.38 (1.00-1.91) and 1.60 (1.08-2.37), respectively. The higher risks were also observed for occasional exposure to engine oil, any products containing lead-like solder lead-free solder, and microbes; the adjusted ORs (95%CIs) were 1.68 (1.02-2.77), 2.03 (1.06-3.88), 3.45 (1.85-6.43), and 4.51, (1.63-12.49), respectively. CONCLUSIONS: Periconceptional paternal occupational exposure was associated with a higher risk of infant CHDs. Further studies using biomarkers of the association between paternal occupational exposure and infant CHDs are warranted.
• COVID-19-related stress, exercise, and oral health-related quality of life among community-dwelling older adults who participated in the CHEER Iwamizawa project, Japan.

  Kazuhito Miura, Yutaka Watanabe, Haruhisa Baba, Kimiya Ozaki, Takae Matsushita, Miyako Kondoh, Kazutaka Okada, Shinji Nakaoka, Katsuhiko Ogasawara, Teppei Suzuki, Hiroshi Saito, Takashi Kimura, Akiko Tamakoshi, Yutaka Yamazaki

  Scientific reports 12 (1) 20347 - 20347 2022/11/27 [Refereed][Not invited]
   

  This study examined the association between coronavirus disease 2019 (COVID-19)-related stress, exercise habits, and oral health-related quality of life (OHRQoL) in a sample of 215 community-dwelling older adults in Japan (57 men, 158 women; Mage = 74.2 years, SD = 6.0). Data were collected during wellness checkups in October 2020 and included participants' demographic characteristics, measures of instrumental activities of daily living and depressive tendencies, number of teeth, oral hypofunction, OHRQoL, COVID-19-related stress, and exercise habits. Four mutually exclusive groups were created, using the presence or absence of COVID-19-related stress and lack of exercise habits as risk factors for poor OHRQoL (no COVID-19-related stress and no lack of exercise, COVID-19-related stress only, lack of exercise habits only, and both COVID-19-related stress and lack of exercise habits). Poisson regression with robust standard errors provided the prevalence ratio for poor OHRQoL. The presence of both COVID-19-related stress and lack of exercise habits (adjusted prevalence ratio: 2.20, 95% CI: 1.31- 3.69) was associated with poor OHRQoL. The results indicate that COVID-19-related stress and exercise habits should be considered when designing oral health and public health initiatives.
• Cigarette smoking, smoking cessation and bladder cancer risk: A pooled analysis of ten cohort studies in Japan.

  Hiroyuki Masaoka, Keitaro Matsuo, Isao Oze, Takashi Kimura, Akiko Tamakoshi, Yumi Sugawara, Ichiro Tsuji, Norie Sawada, Shoichiro Tsugane, Hidemi Ito, Keiko Wada, Chisato Nagata, Tetsuhisa Kitamura, Ling Zha, Ritsu Sakata, Kotaro Ozasa, Yingsong Lin, Tetsuya Mizoue, Keitaro Tanaka, Sarah Krull Abe, Manami Inoue

  Journal of epidemiology 2022/10/29 [Refereed]
   

  BACKGROUND: Although cigarette smoking is an established risk factor for bladder cancer, assessment of smoking impact on bladder cancer in Asian populations has been hindered by few cohort studies conducted in Asian populations. We therefore investigated the risk of bladder cancer associated with smoking status, cumulative smoking intensity and smoking cessation in Japan. METHODS: We analyzed data for 157,295 men and 183,202 women in ten population-based cohort studies in Japan. The risk associated with smoking behaviors was estimated using Cox regression models within each study, and pooled hazard ratios (HR) and their 95% confidence intervals (CI) for the incidence of bladder cancer were calculated. RESULTS: During 4,729,073 person-years of follow up, 936 men and 325 women developed bladder cancer. In men, former smokers (HR 1.47; 95% CI, 1.18-1.82) and current smokers (HR 1.96; 95% CI, 1.62-2.38) had higher risk than never smokers. In women, current smokers had higher risk than never smokers (HR 2.35; 95% CI, 1.67-3.32). HRs in men linearly increased with increasing pack-years. Risk decreased with increasing years of smoking cessation in men with a significant dose-response trend. Former smokers with a duration of more than 10 years after smoking cessation had no significantly increased risk compared with never smokers (HR 1.26; 95% CI, 0.97-1.63). CONCLUSIONS: Data from a pooled analysis of ten population-based cohort studies in Japan clearly show an association between cigarette smoking and bladder cancer risk. The risk of smokers may approximate that of never smokers following cessation for many years.
• Purpose in life (Ikigai) and employment status in relation to cardiovascular mortality: the Japan Collaborative Cohort Study.

  Junji Miyazaki, Kokoro Shirai, Takashi Kimura, Satoyo Ikehara, Akiko Tamakoshi, Hiroyasu Iso

  BMJ open 12 (10) e059725  2022/10/10 [Refereed]
   

  OBJECTIVES: To investigate whether having a purpose in life (Ikigai) is associated with risk of cardiovascular disease (CVD) mortality and whether the association varies by employment status. DESIGN: Prospective cohort study. SETTING: Residents in 45 municipalities, Japan. PARTICIPANTS: 29 517 men and 41 984 women aged 40-79 years, free of CVD and cancer at baseline from 1988 to 1990. PRIMARY OUTCOME MEASURES: CVD mortality. RESULTS: During the median follow-up of 19.1 years, 4680 deaths (2393 men and 2287 women) from total CVD were observed. Greater Ikigai was associated with a lower risk of CVD mortality, and the result was stronger for men than for women. Stratified by employment status, the inverse association was confined to unemployed persons. Among unemployed persons, the multivariable HRs of total CVD were higher for moderate and high versus low levels of Ikigai. Multivariable HRs (95% CIs) were 0.74 (0.57 to 0.97) and 0.69 (0.52 to 0.93), P for trend <0.044, respectively in men, and 0.78 (0.64 to 0.95) and 0.77 (0.61 to 0.97), P for trend=0.039 in women. No association was observed among the employed, including part-time workers, self-employed and homemakers for both men and women. Such an inverse association remained even after excluding early deaths within 5 years from the baseline survey. CONCLUSION: Higher levels of Ikigai were associated with a lower risk of CVD mortality, especially for unemployed men and women.
• Association between gestational weight gain and risk of overweight at 3 years old: The Japan Environment and Children's Study.

  Kanami Tanigawa, Yoko Kawanishi, Satoyo Ikehara, Takashi Kimura, Kimiko Ueda, Tadashi Kimura, Keiichi Ozono, Hiroyasu Iso

  Pediatric obesity 18 (1) e12978  2022/09/14 [Refereed]
   

  BACKGROUND: It is unclear if gestational weight gain (GWG) increases the risk of children with overweight. OBJECTIVES: We examined the association between GWG and the risk of overweight in 3-year-old children in the Japanese nationwide birth cohort study. METHODS: Among 64 336 singleton births, we calculated the risk ratios (RRs) and 95% confidence intervals (95% CIs) of the association between GWG categories and children with overweight, following an adjustment of the confounding variables. RESULTS: GWG was positively associated with the risk of overweight among 3-year-old children. The multivariable RR (95% CI) was 1.21 (1.17-1.25) per 5 kg increase of the GWG. The multivariable RR (95% CI) for excessive GWG was 1.20 (1.12-1.28) and 1.27 (1.16-1.39) based on the modified Japanese and IOM criteria, respectively, compared to adequate GWG. The multivariable RR (95% CI) of overweight with children for inadequate versus adequate GWG was 0.83 (0.78-0.88) and 0.84 (0.79-0.89) based on the modified Japanese and IOM criteria, respectively. CONCLUSIONS: GWG was positively associated with a high risk of overweight at 3 years of age. The risk of offspring overweight was 20%-27% higher and 16%-17% lower with excessive GWG and inadequate GWG, respectively, compared to adequate GWG, based on the aforementioned criteria.
• Changes in social activities and the occurrence and persistence of depressive symptoms: Do type and combination of social activities make a difference?

  Yifan Shan, Wenjing Zhao, Wen Hao, Takashi Kimura, Shigekazu Ukawa, Hideki Ohira, Takashi Kawamura, Kenji Wakai, Masahiko Ando, Akiko Tamakoshi

  Archives of gerontology and geriatrics 104 104800 - 104800 2022/09/05 [Refereed]
   

  OBJECTIVE: We aimed to explore the association between changes in social activities and the occurrence/persistence of depressive symptoms and investigate the difference in effect sizes among the types and combinations of social activities. METHODS: The study adopted a valid 15-item Geriatric Depression Scale to assess depressive symptoms in 2480 community-dwelling adults aged 64/65 years. Changes in social-related, learning, and personal activities were classified into four categories: continued low frequency (CLF), increased frequency (IF), decreased frequency (DF), and continued regular frequency (CRF)1. Relative ratios (RRs) and 95% confidence intervals (95% CI) were calculated using a modified Poisson regression model. RESULTS: Those without depressive symptoms at baseline and who engaged in social-related (RRIF = 0.56 (0.39, 0.81), RRCRF = 0.55 (0.41, 0.74)), learning (RRIF = 0.63 (0.44, 0.89), RRCRF = 0.62 (0.46, 0.85)), and personal activities (RRIF = 0.37 (0.24, 0.57), RRCRF = 0.41 (0.30, 0.56)) at IF or CRF were less likely to develop depressive symptoms. Those with depressive symptoms at baseline, engaging in personal activities at IF (RR=0.67 (0.51, 0.87)) and CRF (RR= 0.80 (0.65-1.00)) were less likely to have persistent depressive symptoms. Participation in all three activities consistently at a regular frequency was inversely associated with the occurrence/persistence of depressive symptoms. CONCLUSIONS: The effect of personal activities was more manifest in preventing depressive symptoms than the other two kinds, regardless of depressive symptoms at baseline. Regularly engaging in a combination of all three activities at baseline and follow-up was associated with the occurrence and persistence of depressive symptoms.
• Association between daily sleep duration and the risk of incident dementia according to the presence or absence of diseases among older Japanese individuals in the New Integrated Suburban Seniority Investigation (NISSIN) project.

  Shigekazu Ukawa, Wenjing Zhao, Satoe Okabayashi, Takashi Kimura, Masahiko Ando, Kenji Wakai, Kazuyo Tsushita, Takashi Kawamura, Akiko Tamakoshi

  Sleep medicine 100 190 - 195 2022/09/03 [Refereed]
   

  OBJECTIVE: This study aimed to investigate the association between daily sleep duration and incident dementia among physically and socially independent older people with/without diseases (hypertension, diabetes mellitus, cardiovascular diseases) in a Japanese age-specific cohort. METHODS: We carried out a prospective cohort study including 1954 (1006 men and 948 women) Japanese individuals aged 64/65 years. Information on daily sleep duration, medical status, demographics, and lifestyle characteristics was collected by a baseline questionnaire survey and health checkup (2000-2005). Dates of incident dementia were confirmed using the nationally standardized dementia scale proposed by the Ministry of Health, Labor, and Welfare. A competing risk model was used to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs) for incident dementia. We treated censored cases due to death as competing events. RESULTS: During a median of 15.6 years of follow-up, 260 participants reported incident dementia. Compared with participants without diseases and who slept 6-7.9 h/day, those with a shorter daily sleep duration of <6 h/day, presence of disease and shorter, moderate, or longer daily sleep duration ≥8 h/day had an increased risk of incident dementia (HR 1.73; 95% CI 1.04-2.88, HR 1.98; 95% CI 1.14-3.44, HR 1.44; 95% CI 1.03-2.00, and HR 2.09; 95% CI 1.41-3.09, respectively) with a significant interaction between the presence of diseases and sleep duration (p < 0.001). CONCLUSIONS: The present findings suggest that habitual sleep duration predicts future risk of dementia.
• Association of dietary diversity with all-cause mortality by body mass index in Japanese older adults: An age-specific prospective cohort study (NISSIN project).

  Saeka Takabayashi, Takumi Hirata, Wenjing Zhao, Takashi Kimura, Shigekazu Ukawa, Kazuyo Tsushita, Kenji Wakai, Takashi Kawamura, Masahiko Ando, Akiko Tamakoshi

  Geriatrics & gerontology international 22 (9) 736 - 744 2022/09 [Refereed]
   

  AIM: Dietary diversity might reduce the risk of malnutrition, although it is also linked to obesity. We examined whether dietary diversity is associated with all-cause mortality in Japanese older adults based on their body mass index (BMI). METHODS: The current study included 2944 people aged 64-65 years who participated in the New Integrated Suburban Seniority Investigation (NISSIN) project from 1996 to 2005. Dietary diversity was measured using the Food Variety Score (FVS), which calculates the frequency of all food items consumed daily using a self-administered food frequency questionnaire. Participants were divided into tertiles according to their FVS (first: low, second: middle, third: high). Multivariate adjusted hazard ratios with 95% confidence intervals were calculated using the Cox proportional hazard regression model. For the stratified analysis, BMI was used to divide the participants into three groups - lean (BMI <20), normal (BMI 20-24.9) and overweight/obese (BMI ≥25). RESULTS: Overall, 454 (30.7%) men and 222 (15.2%) women died over a median follow-up period of 16.6 years. No significant association was observed between FVS and all-cause mortality. However, when grouped by BMI, for the participants in the lean group, the multivariate adjusted hazard ratios were 0.56 (95% confidence interval 0.32-0.96) for the middle FVS and 0.50 (95% confidence interval 0.25-1.02) for the high FVS, compared with the low FVS (P for trend = 0.059). In overweight/obese women, although not significant, total mortality was higher in the middle and high FVS. CONCLUSIONS: These findings show that dietary diversity should be promoted in lean older Japanese adults. Geriatr Gerontol Int 2022; 22: 736-744.
• Changes in behavioral activities and transition of depressive symptoms among younger-old community-dwelling adults during 6 years: An age-specific prospective cohort study.

  Yifan Shan, Wenjing Zhao, Wen Hao, Takashi Kimura, Shigekazu Ukawa, Hideki Ohira, Takashi Kawamura, Kenji Wakai, Masahiko Ando, Akiko Tamakoshi

  International journal of geriatric psychiatry 37 (8) 2022/08 [Refereed]
   

  OBJECTIVE: Regular engagement in behavioral activities plays a crucial role against depressive symptoms in older adults. This study aims to explore the relationship between behavioral activities and the temporal evolution of depressive symptoms. METHODS: We included community-dwelling Japanese adults aged 64 or 65 years with and without depressive symptoms enrolled in the New Integrated Suburban Seniority Investigation (NISSIN) project. Depressive symptoms at baseline and follow-up were assessed using the 15-item Geriatric Depression Scale. Behavioral activities were measured by self-reported questions. Risk ratios and 95% confidence intervals were calculated using modified Poisson regression, adjusting for relevant sociodemographic variables and health-related confounders. RESULTS: During the 6 year follow-up period, 139 (10.1%) without depressive symptoms at baseline developed such symptoms over time, while 174 (51.6%) with depressive symptoms improved to the point of these symptoms being absent. The participants without depressive symptoms at baseline and those who engaged in social activity or daily walking at a continued regular frequency (CRF) or an increased frequency (IF) and exercise habits at CRF were the least likely to have depressive symptoms onset at follow-up. There was no significant difference between the changes in behavioral activities and the improvement of depressive symptoms after controlling for confounders. Participants engaging in a greater variety of behavioral activities at CRF were less likely to experience a new onset of depressive symptoms. CONCLUSIONS: Consistent and regular participation in one or more behavioral activities was significantly associated with the onset of depressive symptoms in Japanese community-dwelling older adults.
• Biennial Changes in the Characteristics of Patients with Methamphetamine Use Disorder in Japan from 2000 to 2020.

  Taisuke Yamamoto, Takashi Kimura, Akiko Tamakoshi, Toshihiko Matsumoto

  Journal of psychoactive drugs 1 - 9 2022/07/27 [Refereed]
   

  Methamphetamine is an illegal drug with the greatest burdens in Japan. Social and medical measures to combat methamphetamine dependence have been implemented, but no reports on changes in the characteristics of methamphetamine use disorder patients have been conducted. We aimed to describe these changes, and provide information on the results of social and medical measures. We concatenated cross-sectional surveys from 2000 to 2020 and analyzed biennial changes. Twenty-year data from 2000 to 2018 were age-weighted according to the age structure in 2020. We performed Cochran-Armitage trend tests for crude and age-weighted changes in patient variables. There was an increase in the number of patients with methamphetamine use disorder undergoing treatment and those with a history of drug-related arrests. Patients who achieved 1-year abstinence increased, and those diagnosed with psychotic disorders decreased. Patients with a history of non-drug-related arrests and without revealing their source of methamphetamine decreased. The ages of the patient population increased, and patients with a history of benzodiazepine misuse increased. Social measures linking methamphetamine users to psychiatric care may increase the number of patients who undergo treatment.
• Scallop aquaculture has a potential risk of natto-induced hypersensitivity reactions in a local area of northern Japan.

  Isaku Kurotori, Takashi Kimura, Wataru Sasao, Masahiko Abe, Hideki Kumagai, Akiko Tamakoshi

  Allergology international : official journal of the Japanese Society of Allergology 72 (1) 128 - 134 2022/07/08 [Refereed]
   

  BACKGROUND: Fermented soybean (natto)-induced hypersensitivity reactions (natto allergy) are rare and can result in late-onset anaphylaxis. The allergen in natto is considered to be poly-γ-glutamic acid (PGA), and marine sports are a risk factor for natto allergy due to epicutaneous sensitization to PGA from cnidarian stings. However, no research on natto allergy in fishery workers has yet been performed. METHODS: We conducted a chart review of inpatients diagnosed with anaphylaxis due to natto at Hokkaido Prefectural Haboro Hospital between April 1, 2009, and August 31, 2020. We also administered self-report questionnaires about food hypersensitivity reactions to Japanese fishery workers, including members of the Kitarumoi Fishery Cooperative Association and part-time workers in this area, from February 1 to May 31, 2021. RESULTS: We found six inpatients (29 inpatients with food-induced anaphylaxis among approximately 11,000 community-dwelling residents) with late-onset anaphylaxis due to natto; all were involved in scallop aquaculture. The questionnaires revealed that 27 participants had natto allergy. We divided the fishery workers into a scallop aquaculture (Scallop) group (n = 211) and other fishery group (n = 106). The Scallop group was significantly associated with natto allergy after adjustments for confounders (OR: 5.73, 95% CI: 1.46-22.56) by logistic regression analysis. In the Scallop group, older age, experience in repairing nets, and a longer length of work experience were significantly related to participants with natto allergy (n = 23), but not participants without natto allergy (n = 181). CONCLUSIONS: Our results indicated an association between scallop aquaculture and natto allergy.
• Sleep duration and risk of cancer incidence and mortality: a pooled analysis of six population-based cohorts in Japan.

  Calistus Wilunda, Sarah Krull Abe, Thomas Svensson, Norie Sawada, Shoichiro Tsugane, Keiko Wada, Chisato Nagata, Takashi Kimura, Akiko Tamakoshi, Yumi Sugawara, Ichiro Tsuji, Hidemi Ito, Tetsuhisa Kitamura, Ritsu Sakata, Tetsuya Mizoue, Keitaro Matsuo, Keitaro Tanaka, Yingsong Lin, Manami Inoue

  International journal of cancer 2022/05/26 [Refereed]
   

  Sleep duration is emerging as an important modifiable risk factor for morbidity and mortality. We assessed the association between sleep duration and cancer incidence and mortality among Japanese adults using data from six population-based cohorts with 271 694 participants. During a total follow-up period of about 5.9 million person-years, we identified 40 751 incident cancer cases and 18 323 cancer deaths. We computed study-specific hazard ratios (HRs) and 95% confidence intervals (CIs) using Cox proportional hazards regression models and pooled the estimates using random-effects meta-analysis. Sleep duration of ≥ 10 h (vs. 7 h) was associated with increased risk of cancer incidence among women (HR 1.19, 95% CI 1.02-1.38), but not men, and increased risk of cancer mortality among men (HR 1.18, 95% CI 1.00-1.39) and women (HR 1.44, 95% CI 1.20-1.73). Sleep duration of ≤ 5 h (vs. 7 h) was not associated with cancer incidence and mortality. However, among post-menopausal women, sleep durations of both ≤ 5 h and ≥ 10 h (vs. 7 h) were associated with an increased risk of cancer mortality. Among Japanese adults, sleep duration of ≥ 10 h is associated with increased risk of cancer incidence and mortality among women and cancer mortality among men. This article is protected by copyright. All rights reserved.
• Association of Marital Status With Total and Cause-Specific Mortality in Asia.

  Chi Yan Leung, Hsi-Lan Huang, Sarah Krull Abe, Eiko Saito, Md Rashedul Islam, Md Shafiur Rahman, Ai Ikeda, Norie Sawada, Akiko Tamakoshi, Yu-Tang Gao, Woon-Puay Koh, Xiao-Ou Shu, Ritsu Sakata, Ichiro Tsuji, Jeongseon Kim, Sue K Park, Chisato Nagata, San-Lin You, Jian-Min Yuan, Myung-Hee Shin, Wen-Harn Pan, Shoichiro Tsugane, Takashi Kimura, Wanqing Wen, Hui Cai, Kotaro Ozasa, Sanae Matsuyama, Seiki Kanemura, Yumi Sugawara, Aesun Shin, Keiko Wada, Chien-Jen Chen, Renwei Wang, Yoon-Ok Ahn, Habibul Ahsan, Paolo Boffetta, Kee Seng Chia, Keitaro Matsuo, You-Lin Qiao, Nathaniel Rothman, Wei Zheng, Daehee Kang, Manami Inoue

  JAMA network open 5 (5) e2214181  2022/05/02 [Refereed]
   

  Importance: Marital status has been shown to be associated with mortality, but evidence in Asian populations is limited. Objective: To examine the association of marital status with total and cause-specific mortality. Design, Setting, and Participants: This cohort study included individual participant data from 16 prospective studies in the Asia Cohort Consortium conducted between 1963 and 2015. Asian participants with complete information on marital and vital status were included. Study-specific hazard ratios (HRs) and 95% CIs were estimated using Cox proportional hazards model and then pooled using a random-effects meta-analysis. The analysis began in February 2021 and ended in August 2021. Exposures: Marital status. Main Outcomes and Measures: All-cause and cause-specific mortality. Results: Of 623 140 participants (326 397 women [52.4%] and 296 743 men [47.6%]; mean [SD] age, 53.7 [10.2] years; mean [SD] follow-up time, 15.5 [6.1] years), 123 264 deaths were ascertained. Compared with married individuals, those who were unmarried had pooled HRs of 1.15 (95% CI, 1.07-1.24) for total mortality, 1.12 (95% CI, 1.03-1.22) for cerebrovascular disease mortality, 1.20 (95% CI, 1.09-1.31) for coronary heart disease mortality, 1.17 (95% CI, 1.07-1.28) for circulatory system diseases mortality, 1.06 (95% CI, 1.01-1.11) for cancer mortality, 1.14 (95% CI, 1.05-1.23) for respiratory diseases mortality, and 1.19 (95% CI, 1.05-1.34) for external causes of death. Positive associations with total mortality were also observed for those who were single (HR, 1.62; 95% CI, 1.41-1.86), separated (HR, 1.35; 95% CI, 1.13-1.61), divorced (HR, 1.38; 95% CI, 1.13-1.69), and widowed (HR, 1.09; 95% CI, 1.04-1.13). In subgroup analyses, the positive association persisted across baseline health conditions, and the risk of death was more pronounced among men or people younger than 65 years. Conclusions and Relevance: This large pooled cohort study of individual participant data provides strong evidence that being unmarried, as well as belonging to the unmarried subcategories, was positively associated with total and cause-specific mortality. Investment of targeted social support services might need to be considered in light of the mortality differences between married and unmarried individuals.
• 平成30年北海道胆振東部地震における大規模停電時の札幌市在宅人工呼吸器患者への対応の実態と課題

  方波見 謙一, 木村 尚史, 玉腰 暁子

  日本在宅救急医学会誌 (一社)日本在宅救急医学会 5 (2) 1 - 7 2436-066X 2022/03 

  【目的】平成30年北海道胆振東部地震に伴った停電における、札幌市在宅人工呼吸器患者への対応の実態と入院となったリスク要因を検討する。【方法】札幌市在宅医療協議会所属会員を対象として行われたアンケート調査を利用し、本研究を行った。【結果】札幌市内の在宅人工呼吸器患者数は230名であった。使用時間が常時(24時間)であれば入院に対するPR(prevalence ratio)は9.07(95%CI:5.10～16.10、p<.0001)、人工呼吸器設定についてはTPPV(tracheostomy positive pressure ventilation)の場合、TPPVではない場合に比べ入院に対するPRは3.57(95%CI:2.29～5.55、p<.0001)であった。年齢と使用時間による多変量解析では、使用時間のPRが9.21(95%CI:5.17～16.39、p<.0001)であった。入院とならなかった患者は147名であり、入院回避の理由として、電源が確保できたが87名(59.2%)で、自家用車からの電源確保が35名(40.2%)であった。【結語】災害に伴った停電時には在宅人工呼吸器24時間使用は入院のリスクとなる。リスクが高い患者において日ごろから自家用車などの非常電源を確保しておくことが、災害急性期の停電対策として重要である。(著者抄録)
• Associations of social capital and health at a city with high aging rate and low population density

  Jun-ichiro Watanabe, Takashi Kimura, Takahiro Nakamura, Daisuke Suzuki, Takashi Takemoto, Akiko Tamakoshi

  SSM - Population Health 17 100981 - 100981 2352-8273 2022/03 [Refereed]
  
• Variables associated with methamphetamine use within the past year and sex differences among patients with methamphetamine use disorder: A cross-sectional study in Japan.

  Taisuke Yamamoto, Takashi Kimura, Akiko Tamakoshi, Toshihiko Matsumoto

  The American journal on addictions 31 (2) 134 - 141 2022/01/31 [Refereed]
   

  BACKGROUND AND OBJECTIVES: Methamphetamine use disorder is the most common reason for psychiatrist visits among illicit drug users in Japan. Although variables associated with methamphetamine use and sex differences have been reported in the United States, Australia, and Asian countries, such studies are rare in Japan. We examined methamphetamine use within the past year among patients receiving treatment by sex and proposed important treatment targets. METHODS: This cross-sectional study analyzed the Nationwide Mental Hospital Survey on Drug-related Psychiatric Disorders. We divided 1086 men and 376 women into two groups according to methamphetamine use within the past year and conducted log-binomial regression analyses by sex to examine the variables associated with methamphetamine use. For methamphetamine users, the source was identified. RESULTS: Women were more likely to obtain methamphetamine from their friends, acquaintances, family members, or partners than men. Multivariable regression analysis showed that younger age in both sexes and higher educational attainment (prevalence ratio [PR] = 1.29; 95% confidence interval [CI] = 1.06-1.57) and employment (PR = 1.26; 95% CI = 1.05-1.51) were associated with methamphetamine use in men. Age-adjusted regression analysis showed that the variables associated with methamphetamine use were comorbid alcohol abuse and cannabis abuse in women and benzodiazepine abuse in both sexes. CONCLUSION AND SCIENTIFIC SIGNIFICANCE: In women, in particular, the surrounding relationships related to methamphetamine might be considered treatment targets. Young and working patients might need more accessible outpatient clinics and treatment programs. Comorbid substance abuse should be assessed and treated.
• Oral frailty and carriage of oral Candida in community-dwelling older adults (Check-up to discover Health with Energy for senior Residents in Iwamizawa; CHEER Iwamizawa).

  Haruhisa Baba, Yutaka Watanabe, Kazuhito Miura, Kimiya Ozaki, Takae Matsushita, Miyako Kondoh, Kazutaka Okada, Akira Hasebe, Tokiyoshi Ayabe, Kiminori Nakamura, Shinji Nakaoka, Katsuhiko Ogasawara, Teppei Suzuki, Hiroshi Saito, Takashi Kimura, Akiko Tamakoshi, Yutaka Yamazaki

  Gerodontology 39 (1) 49 - 58 2022/01/31 [Refereed]
   

  OBJECTIVE: To examine the association between oral frailty and oral Candida carriage as a general indicator of deteriorating oral function in older adults. BACKGROUND: Older adults exhibit an elevated risk of oral candidiasis caused by Candida. Although many studies have identified factors associated with oral Candida carriage, none have evaluated its relationship with oral function. MATERIALS AND METHODS: This study included 210 community-dwelling older adults aged ≥60 years who participated in wellness checks. Fungal flora expression in saliva samples was evaluated to identify oral C. albicans and C. glabrata. Participants were categorised by detection of neither strain (group 1), either one of the strains (group 2), or both strains (group 3). The relationship between oral Candida carriage and oral frailty was evaluated by multinomial logistic regression analysis. RESULTS: The participants included 58 men and 152 women with a mean age of 74.2 ± 6.1 years. A total of 88 (41.9%), 94 (44.8%) and 28 (13.3%) participants were assigned to groups 1, 2 and 3 respectively. In the multinomial logistic regression analysis, significant associations were observed between group 1 and group 2 for "Have you choked on your tea or soup recently?" and the number of applicable oral frailty items. Between group 1 and group 3, significant associations were observed for the number of remaining teeth, masticatory performance and the number of applicable oral frailty items. CONCLUSION: We obtained basic data useful for intervention studies aimed at verifying whether oral function management prevents deterioration of the oral bacterial flora.
• Association of accelerometer-measured physical activity with kidney function in a Japanese population: the DOSANCO Health Study.

  Sachiko Sasaki, Koshi Nakamura, Shigekazu Ukawa, Emiko Okada, Shiho Amagasa, Shigeru Inoue, Takashi Kimura, Aya Yoshimura, Aya Tanaka, Takafumi Nakagawa, Akihiro Imae, Akiko Tamakoshi

  BMC nephrology 23 (1) 7 - 7 2022/01/03 [Refereed]
   

  BACKGROUND: Sedentary behavior and decreased physical activity are associated with reduced kidney function, yet most evidence is based on self-reported physical activity. This study investigated the association between accelerometer-based physical activity level and kidney function in a general Japanese population. METHODS: A cross-sectional study was conducted in 440 community-dwelling Japanese participants, aged 35-79 years. Time (min/d) was assessed for the following types of physical activity: sedentary behavior, light physical activity (LPA), and moderate-to-vigorous physical activity (MVPA). Kidney function was assessed using estimated glomerular filtration rate (eGFR). A linear regression model was employed to calculate the β coefficient of eGFR for a 60-min/d increase in sedentary behavior and LPA and a 10-min/d increase in MVPA. A logistic regression model was used to calculate the odds ratio for low eGFR (< 60 versus ≥60 mL/min/1.73m2) for a 60-min/d or 10-min/d increase in each physical activity type. RESULTS: MVPA time and eGFR were positively associated in both men and women, after adjusting for age, body mass index, and other clinical characteristics (Men: β, 0.91; P = 0.021; Women: β, 0.70; P = 0.034). In women, sedentary behavior and eGFR were inversely associated after adjusting for the same factors (β, - 1.06; P = 0.048). The odds ratio (95% confidence interval) for low eGFR associated with a 60-min increase in sedentary behavior was 1.65 (1.07-2.55) after adjusting for the same factors in women. CONCLUSION: Longer sedentary behavior and shorter MVPA time were associated with lower kidney function in the Japanese population.
• Low Periconceptional Dietary Intakes among Japanese Women: The Japan Environment and Children's Study (JECS).

  Ehab S Eshak, Chika Okada, Takashi Kimura, Sachiko Baba, Satoyo Ikehara, Hiroyasu Iso, For The Jecs Group

  Journal of nutritional science and vitaminology 68 (4) 260 - 269 2022 [Refereed]
   

  Pregnancy is usually associated with dietary imbalances. We aim to assess the changes in Japanese women's diet and nutritional adequacy before and during pregnancy. In the Japan Environment and Children's Study (JECS), we recruited a large cohort of pregnant women (>100,000) from 15 Japanese communities. We assessed their diet before and during pregnancy by a food frequency questionnaire. The before and during pregnancy intakes of energy, macronutrients, and micronutrients were lower than the recommended level for Japanese women by 1% to 49%. The dietary intakes of pregnant women were lower than their intakes before pregnancy, except for milk, dairy products, and calcium. The daily during pregnancy intake of energy, carbohydrate, fat, protein, folic acid, and iron decreased by 85 kcal, 11.6 g, 2.3 g, 2.8 g, 20 μg, and 0.5 mg than the before pregnancy intake. Pregnant women's declined food and nutrients intakes were moderately correlated to their dietary intakes before pregnancy; the correlation coefficient ranged between 0.47 and 0.67. The inter-individual variability was greater than the intra-individual variability of the dietary intakes. Almost half of the pregnant women remained in the same intake quartile for all nutrients and food groups as before pregnancy. Yet, approximately 10% of pregnant women changed their pregnancy intake by ≥50% (≥2 quartiles up or down) compared to before pregnancy. In conclusion, the study identified low periconceptional dietary intakes among Japanese pregnant women. The low dietary intake of essential nutrients, such as folate, requires revising the Japanese national periconceptional dietary and supplementation guidelines.
• Green Tea Consumption and Risk of Depression Symptoms: A Systematic Review and Meta-Analysis of Observational Studies.

  Akinori Yaegashi, Takashi Kimura, Takumi Hirata, Akiko Tamakoshi

  Journal of nutritional science and vitaminology 68 (3) 155 - 161 2022 [Refereed]
   

  This systematic review and meta-analysis aimed to investigate the association between green tea consumption and depression symptom risk, using subgroup analyses concerning study design, geographical region of study, adjustment factors, age, cut-off for the highest consumption category, and depression assessment methods applied. We used PubMed to search for relevant literature. The inclusion criteria were studies that (a) investigated this association as a primary or secondary outcome; (b) published in English; (c) assessed and reported hazard ratios or odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) for depression symptoms, or included sufficient information to allow their calculation; (d) included at least two groups differentiated based on green tea consumption (e.g., high and low); (e) reported the prevalence of depression symptoms in each group; and (f) reported the sample size for each group. Eight articles were found to meet all criteria. The results indicated that high green tea consumption is inversely associated with depression symptoms. The pooled OR was 0.66 (95% CI 0.58-0.74), and significant heterogeneity was not observed. Subgroup analysis showed that study design impacted results (cohort study [one study]: OR=0.29, 95% CI=0.04-2.14; cross-sectional study [seven studies]: OR=0.66, 95% CI=0.59-0.75). These findings suggest that green tea consumption reduces the risk of depression symptoms. This association was also observed in the cohort study included, but the results in which did not reach the significant level. Therefore, further cohort studies are needed to confirm the potential causal relationship in this regard.
• Risk Factors of Mortality from Foreign Bodies in the Respiratory Tract: The Japan Collaborative Cohort Study.

  Kenichi Katabami, Takashi Kimura, Takumi Hirata, Akiko Tamakoshi

  Internal medicine (Tokyo, Japan) 61 (9) 1353 - 1359 2022 [Refereed]
   

  Objective This study assessed the risk factors of mortality from foreign bodies in the respiratory tract using the Japan Collaborative Cohort Study for the Evaluation of Cancer Risk data. Methods Data of 110,585 participants 40-79 years old living in 45 areas in Japan were collected between 1988 and 2009. Mortality from foreign bodies in the respiratory tract was assessed in a multivariable-adjusted analysis using a Cox proportional hazard regression model. Results Among all participants, 202 deaths occurred from foreign bodies in the respiratory tract. In the multivariable-adjusted model, older age [50-59 (hazard ratio, 4.93; 95% confidence interval, 1.91-12.74), 60-69 (hazard ratio, 14.96, 6.01-37.25) and 70-79 (hazard ratio, 53.81; 95% confidence interval, 21.44-135.02) years old compared to 40-49 years old], male sex (hazard ratio, 2.34; 95% confidence interval, 1.54-3.54), a history of apoplexy (hazard ratio, 7.04; 95% confidence interval, 4.24-11.67) and the absence of a spouse (hazard ratio, 1.56; 95% confidence interval, 1.05-2.32) were associated with an increased risk of mortality from foreign bodies in the respiratory tract. Conclusions Older age, male sex, medical history of apoplexy and the absence of a spouse were potential risk factors of mortality from foreign bodies in the respiratory tract. Especially in elderly men, social connections, such as cohabitation or relationships, may be important for ensuring the early detection of asphyxia and preventing death due to foreign bodies in the respiratory tract.
• Adult height in relation to the risk of colorectal cancer among the Japanese population: an evaluation based on systematic review and meta-analysis.

  Rachana Manandhar Shrestha, Tetsuya Mizoue, Norie Sawada, Keitaro Matsuo, Keiko Wada, Keitaro Tanaka, Yingsong Lin, Yumi Sugawara, Hidemi Takimoto, Takashi Kimura, Hidemi Ito, Tetsuhisa Kitamura, Ritsu Sakata, Shiori Tanaka, Manami Inoue

  Japanese journal of clinical oncology 2021/12/29 [Refereed]
   

  OBJECTIVE: The association between adult-attained height and risk of colorectal cancer remains elusive among the Japanese population. We performed a systematic review and meta-analysis of epidemiological studies in Japan. METHODS: We systematically searched the MEDLINE (PubMed) and Ichushi databases and complemented it with manual search to identify eligible studies. We extracted relative risks or odds ratios from the selected studies and conducted meta-analysis to estimate the summary relative risk with 95% confidence interval. We made the final judgment based on a consensus of the research group members considering both epidemiological evidence and biological plausibility. RESULTS: This systematic review identified four cohort and one case-control studies among the Japanese. The meta-analysis of these five studies showed the summary relative risk of 1.21 (95% confidence interval: 1.07-1.35) of overall colorectal cancer for the highest vs. lowest categories of height. In the analysis by the cancer subsite, the association was significant for colon cancer with a summary relative risk of 1.26 (95% confidence interval: 1.10-1.45) but not for rectal cancer 1.05 (95% confidence interval: 0.71-1.54). In the analysis by sex, tall stature was associated with a significantly increased risk of overall colorectal cancer in both sexes; the summary relative risk was 1.21 (95% confidence interval: 1.04-1.41) in men and 1.20 (95% confidence interval: 1.00-1.44) in women, respectively. CONCLUSIONS: The evidence to support that adult-attained height is associated with increased risk of colorectal cancer (colon cancer) among the Japanese population is 'probable'.
• Association of dietary protein intake with skeletal muscle mass in older adults: A systematic review.

  Akinori Yaegashi, Takashi Kimura, Takumi Hirata, Akiko Tamakoshi

  Geriatrics & gerontology international 21 (12) 1077 - 1083 2021/12 [Refereed]
   

  Protein supplementation has been shown to be effective in attenuating the loss of lean body mass and muscle mass in older adults; however, its benefits as dietary protein remain unclear. This systematic review of observational studies aimed to investigate the association of dietary protein intake with skeletal muscle mass (SM). Observational studies that investigated the association of dietary protein intake with SM in older adults were retrieved from MEDLINE, Web of Science and Cochrane-CENTRAL databases. Of the 26 analyses in the 17 studies, 18 showed a significant positive association. In cohort studies, 55.6% (five of nine analyses) showed a significant positive association. Of these, four analyses were adjusted for well-known confounding factors, used energy-adjusted protein intake, and used the amount of change of SM between baseline and follow-up as the outcome, with two of them showing a significant positive association. Although 69.2% (18 of 26 analyses) of the 17 studies showed a significant positive association between dietary protein intake and SM in older adults, most studies were cross-sectional and had at least one important methodological limitation. Therefore, we could not draw any conclusions. Thus, well-designed cohort studies are needed in future to identify the association between dietary protein intake and SM in older adults. Geriatr Gerontol Int 2021; ••: ••-••.
• Association between pre-pregnancy body mass index and gestational weight gain and perinatal outcomes in pregnant women diagnosed with gestational diabetes mellitus: The Japan Environment and Children's Study.

  Yoshihiro Saito, Sumitaka Kobayashi, Atsuko Ikeda-Araki, Sachiko Ito, Chihiro Miyashita, Takashi Kimura, Takumi Hirata, Akiko Tamakoshi, Michinori Mayama, Kiwamu Noshiro, Kinuko Nakagawa, Takeshi Umazume, Kentaro Chiba, Satoshi Kawaguchi, Mamoru Morikawa, Kazutoshi Cho, Hidemichi Watari, Yoshiya Ito, Yasuaki Saijo, Reiko Kishi

  Journal of diabetes investigation 13 (5) 889 - 899 2021/11/30 [Refereed]
   

  AIMS/INTRODUCTION: We investigated the association between gestational diabetes mellitus (GDM) and perinatal outcomes stratified by pre-pregnancy body mass index (BMI) and/or gestational weight gain (GWG). MATERIALS AND METHODS: Data from the national birth cohort in the Japan Environment and Children's Study from 2011 to 2014 (n = 85,228) were used. Japan uses GDM guidelines of the International Association of Diabetes and Pregnancy Study Groups. The odds ratios (ORs) of perinatal outcomes were compared between women with and those without GDM. RESULTS: The OR (95% confidence interval [CI]) of having an SGA infant in the GDM group with a pre-pregnancy BMI of ≥25.0 kg/m2 and insufficient GWG (<2.75 kg) was 1.78 (1.02-3.12). The OR of having a large-for-gestational-age (LGA) infant of same BMI group with excessive GWG (>7.25 kg) was 2.04 (1.56-2.67). The OR of hypertensive disorders of pregnancy (HDP) was higher in women with a BMI ≥18.5 kg/m2 in the GDM group than in the non-GDM group. CONCLUSIONS: LGA and HDP were associated with pre-pregnancy BMI and GWG in either normal weight or overweight/obese women, and the relationship was strengthened when GDM was present. Women with GDM and a BMI of ≥25.0 kg/m2 are at risk of having SGA and LGA infants depending on GWG.
• Association of gait with global cognitive function and cognitive domains detected by MoCA-J among community-dwelling older adults: a cross-sectional study.

  Wen Hao, Wenjing Zhao, Takashi Kimura, Shigekazu Ukawa, Ken Kadoya, Katsunori Kondo, Akiko Tamakoshi

  BMC geriatrics 21 (1) 523 - 523 2021/10/02 [Refereed][Not invited]
   

  BACKGROUND: Gait was proved to be strongly associated with global cognitive function and multiple cognitive domains; however, previous research usually concentrated on individual gait parameters. This study used wearable sensors to measure gait parameters in different aspects and comprehensively explored the association of gait with global cognitive function and cognitive domains. METHODS: The data of this cross-sectional study were obtained from 236 community-dwelling Japanese older adults (125 men and 111 women) aged 70-81 years. Gait was measured by asking participants to walk a 6-m course and back using the Physilog® sensors (GaiUp®, Switzerland). Global cognitive function and cognitive domains were evaluated by face-to-face interviews using the Japanese version of the Montreal Cognitive Assessment. Twenty gait parameters were summarized as independent gait factors using factor analysis. A generalized linear model and linear regression model were used to explore the relationship of gait with global cognitive function and cognitive domains adjusted for several confounding factors. RESULTS: Factor analysis yielded four gait factors: general cycle, initial contact, propulsion, and mid-swing. Among them, general cycle factor was significantly associated with global cognitive function (β = - 0.487, [- 0.890, - 0.085]) and executive function (P = 0.049); initial contact was associated with executive function (P = 0.017). CONCLUSION: General cycle of gait might be the better marker of global cognitive function and gait is most strongly associated with executive function. The longitudinal relationships should be examined in future cohort studies.
• Peanut Consumption and Risk of Stroke and Ischemic Heart Disease in Japanese Men and Women: The JPHC Study.

  Satoyo Ikehara, Hiroyasu Iso, Yoshihiro Kokubo, Kazumasa Yamagishi, Isao Saito, Hiroshi Yatsuya, Takashi Kimura, Norie Sawada, Motoki Iwasaki, Shoichiro Tsugane

  Stroke 52 (11) STROKEAHA120031212 - 3550 2021/09/09 [Refereed][Not invited]
   

  BACKGROUND AND PURPOSE: Several prospective cohort studies and a randomized clinical trial have shown the beneficial effects of peanut consumption on cardiovascular disease and its risk factors. We examined the association between peanut consumption and risk of cardiovascular disease in Japanese men and women. METHODS: We analyzed data of 74 793 participants aged 45 to 74 years who completed a lifestyle questionnaire including the validated food frequency questionnaire in the Japan Public Health Center-based Prospective Study. They were followed up from 1995 to 2009 for cohort I and from 1998 to 1999 to 2012 for cohort II. Peanut consumption was calculated from the food frequency questionnaire, and the end points were incidence of stroke, ischemic heart disease, and cardiovascular disease (stroke and ischemic heart disease). RESULTS: During a median follow-up of 14.8 years, 3,599 strokes and 849 ischemic heart diseases were reported. Higher peanut consumption was associated with reduced risks of total stroke, ischemic stroke, and cardiovascular disease among men and women. The multivariable hazard ratios (95% CIs) for the highest versus lowest quartiles of peanut consumption after adjustment for age, sex, public health center, smoking, alcohol consumption, perceived stress level, physical activity, vegetable, fruit, fish, soy, sodium and total energy intakes, body mass index, history of hypertension, history of diabetes, and cholesterol-lowering drug were 0.84 (0.77-0.93, P for trend=0.002) for total stroke, 0.80 (0.71-0.90, P for trend=0.002) for ischemic stroke, 0.93 (0.79-1.08, P for trend=0.27) for hemorrhagic stroke, 0.97 (0.80-1.17, P for trend=0.81) for ischemic heart disease and 0.87 (0.80-0.94, P for trend=0.004) for cardiovascular disease, and these associations were similarly observed in both sexes. CONCLUSIONS: Higher peanut consumption was associated with reduced risk of stroke, especially ischemic stroke, but not ischemic heart disease in Japanese men and women.
• Fecal short-chain fatty acids and obesity in a community-based Japanese population: The DOSANCO Health Study.

  Ryodai Yamamura, Koshi Nakamura, Shigekazu Ukawa, Emiko Okada, Takafumi Nakagawa, Akihiro Imae, Tadao Kunihiro, Takashi Kimura, Takumi Hirata, Akiko Tamakoshi

  Obesity research & clinical practice 15 (4) 345 - 350 2021/06/11 [Refereed][Not invited]
   

  In Western populations, fecal concentrations of short-chain fatty acids (SCFAs) are positively correlated with the prevalence of obesity. However, gut microbiota involved in the production of SCFA varies between races. Our purpose was to investigate the associations between fecal SCFAs and the prevalence of obesity in a community-based Japanese population. We classified a total of 568 participants aged ≥18 into four quartiles of fecal concentrations of SCFA subtypes (acetate, butyrate, and propionate) and total SCFAs to compare the prevalence of obesity, defined as a body mass index ≥ 25.0 kg/m2. Using the first quartile SCFA group as a reference, the prevalence ratios of obesity were calculated for each SCFA group through a log-binomial regression model adjusted for major potentially confounding factors including age, sex, exercise habits, total energy intake, and total dietary fiber intake. In the study population, the prevalence of obesity was 35.8%. The prevalence ratios (95% confidence intervals) of obesity in the second, third, and fourth quartile groups of fecal total SCFAs were 1.30 (0.89-1.89), 1.74 (1.23-2.47) and 1.70 (1.19-2.41), respectively, after adjusting for the confounders. Similar positive associations were observed for every subtype. The prevalence ratios (95% confidence intervals) in the fourth quartile groups of fecal acetate, butyrate, and propionate were 1.41 (1.02-1.97), 2.16 (1.49-3.14), and 1.97 (1.35-2.89), respectively, after adjusting for the confounders. In conclusion, our results demonstrated that fecal SCFA concentrations of every subtype were positively associated with the prevalence of obesity in a community-based Japanese population.
• 薬局を対象とした「指定成分等含有食品」の認知度および流通状況に関する横断研究

  藤井 仁, 湯川 慶子, 新井 一郎, 児玉 知子, 木村 尚史

  Therapeutic Research ライフサイエンス出版(株) 42 (6) 423 - 429 0289-8020 2021/06 [Refereed][Not invited]
   

  目的:2020年の改正食品衛生法で定められた4つの指定成分を含む健康食品が薬局でどの程度流通しているのか、特に取り扱いが多い薬局の特徴は何か、薬局でどの程度指定成分等含有食品のことが知られているかを明らかにすることを目的とする。方法:調査会社を通じて全国の薬局名簿から完全無作為に抽出した薬局1000店舗の仕入れ担当者に調査票を郵送し、(1)健康食品を取り扱っているか、(2)指定成分等含有食品が4つ定められる予定であることを知っているか、(3)4つの指定成分等含有食品が何かを知っているか、(4)4つの指定成分等含有食品を過去に取り扱ったことがあるか、(5)4つの指定成分等含有食品を今販売しているか、(6)今後、4つの指定成分等含有食品の取り扱いを続けるか、止めるか、(7)新たに既存の健康食品が指定成分等含有食品に指定されたらどのような対応をとるか、などについて質問した。結果:183の薬局からの回答を分析対象とした。有効回答率18.3%であった。制度自体の認知度、健康被害の報告義務、4つの指定成分等含有食品の名称、過去に生じた健康被害等についての認知度は非常に低かった。また、501社以上の規模をもつ大手チェーン店とネット販売をしている業者で認知度が高かった。結論:指定成分等含有食品の認知度は非常に低かったが、指定成分等含有食品が健康被害を生じさせうる商品であり、健康被害が生じた際には報告の義務が課されることを認識したうえで販売を続けようとする担当者はおらず、適切な情報提供によって販売を自制させることができると考えられた。また、ネット販売をしている薬局では指定成分等含有食品の認知度が高く、これらの業者は実店舗では販売しないがネットを介して販売している可能性があり、注意喚起が必要であると考えられる。(著者抄録)
• Risk Factors for Gallstones and Cholecystectomy: a Large-Scale Population-Based Prospective Cohort Study in Japan.

  Hugh Shunsuke Colvin, Takashi Kimura, Hiroyasu Iso, Satoyo Ikehara, Norie Sawada, Shoichiro Tsugane

  Digestive diseases (Basel, Switzerland) 40 (3) 385 - 393 2021/05/21 [Refereed][Not invited]
   

  INTRODUCTION: Studies investigating the risk of gallstones in the Japanese population are sparse. To our knowledge, this is the first prospective cohort study assessing risk factors of gallstones in Japan. METHODS: A nationwide population-based prospective cohort of 112,109 men and women, aged 40-69 years, self-completed questionnaires at baseline regarding exposures to potential risk factors, between 1990 and 1994. The occurrence of gallstones and cholecystectomy for gallstones were ascertained from another questionnaire after 10 years. Odds ratios and the 95% confidence intervals were calculated using the multivariate logistic regression. RESULTS: During the 10-year follow-up, 3,092 (5.0%) participants developed gallstones and 729 (1.2%) participants required cholecystectomy. Increasing age, high body mass index, and diabetes mellitus were associated with the risk of gallstones in both sexes. In men, weight gain or loss of >5 kg over the follow-up period and stress were associated with risk of gallstones, whereas alcohol intake was inversely associated with the risk. In women, weight gain of >5 kg during the follow-up period, smoking, menopause, and lipid-lowering drugs were associated with risk of gallstones, whereas late onset of menarche was inversely associated with risk of gallstones. The risk of cholecystectomy broadly reflected the risk of gallstones for both sexes respectively. CONCLUSION: Risk factors for both gallstones and cholecystectomy for gallstones are multifactorial and differ between men and women. Novel findings in this study include an inverse association between late onset of menarche and gallstones, and an association between self-reported stress in men and gallstones.
• 北海道在住高齢者の近隣環境の認識と冬季における歩数

  田中 綾, 鵜川 重和, 佐々木 幸子, 吉村 彩, 天笠 志保, 井上 茂, 木村 尚史, 近藤 克則, 玉腰 暁子

  北海道公衆衛生学雑誌 北海道公衆衛生学会 34 (2) 101 - 108 0914-2630 2021/03 [Refereed][Not invited]
   

  目的 積雪寒冷地域である北海道6町に在住する高齢者の近隣環境の認識と冬季における1日平均歩数の目標達成との関連を明らかにする。対象と方法 要介護認定を受けていない69〜78歳、569人を対象に、環境に関する自記式質問紙調査と、3軸加速度活動量計による活動量調査を行い、データの得られた457人を解析対象者とした。1日の平均歩数を厚生労働省の示す目標値によって、目標達成群(男性7,000歩以上、女性6,000歩以上)と目標未達成群に分類し分析を行った。結果 目標達成群には男性の13.1%、女性の17.2%が分類された。運動や散歩に適した公園や歩道があることはないことに比べ冬季の歩数の性別、年齢で調整した目標達成割合比は1.86(95% CI:0.92-3.74)、生鮮食料品が手に入る商店・施設・移動販売が身近にあることは、ないことに比べ0.90(95% CI:0.57-1.45)だった。考察 積雪寒冷地域であっても運動や散歩に適した公園や歩道があることで、冬季においても歩数を維持できる可能性が示唆された。(著者抄録)
• Antenatal pain, intimate partner violence, and maternal bonding disorder: data from the Japan Environment and Children's Study.

  Keiko Yamada, Takashi Kimura, Meishan Cui, Yasuhiko Kubota, Eizaburo Tanaka, Kenta Wakaizumi, Satoyo Ikehara, Tadashi Kimura, Hiroyasu Iso

  Pain 162 (3) 749 - 759 2021/03/01 [Refereed][Not invited]
   

  ABSTRACT: This prospective study examined (1) whether antenatal pain is associated with postnatal maternal bonding disorder (MBD) through postnatal depression and (2) whether intimate partner violence (IPV) has a moderating effect on the association between antenatal pain and postnatal MBD. We analyzed 77,326 pregnancies of women who completed self-report questionnaires including the SF-8 bodily pain item, the Edinburgh Postnatal Depression Scale, the Mother-to-Infant Bonding Scale, and an assessment of IPV. We conducted a mediation analysis to assess whether postnatal depression mediated the association between antenatal pain and MBD 1 year after delivery. A moderated mediation model was used to examine the conditional effect of IPV during pregnancy on the association between antenatal pain and postnatal MBD, operating through postnatal depression. All analyses were adjusted for demographic factors, socioeconomic factors, perinatal and infant factors, medical history, and psychological status. Of the 77,326 pregnancies, 5420 (7.0%) were characterized by persistent moderate-to-severe pain. The total effect of antenatal pain on MBD was significant (standardized path coefficient = 0.06, 95% confidence interval, 0.05-0.06) and postnatal depression dominantly mediated the association between antenatal pain and postnatal MBD (70.8% mediation). Contrary to our hypothesis, IPV during pregnancy did not moderate the association between antenatal pain and postnatal MBD. However, IPV during pregnancy did have independent negative effects on both postnatal depression and MBD. Our findings suggest that antenatal pain and postnatal depression should be assessed and treated with consideration of the presence of IPV during pregnancy to better monitor and prevent the development of MBD.
• Hypertensive Disorders of Pregnancy in Relation to Coffee and Tea Consumption: The Japan Environment and Children's Study.

  Yoko Kawanishi, Aiko Kakigano, Takashi Kimura, Satoyo Ikehara, Takuyo Sato, Takuji Tomimatsu, Tadashi Kimura, Hiroyasu Iso, On Behalf Of The Japan Environment And Children's Study Group

  Nutrients 13 (2) 2021/01/24 [Refereed]
   

  BACKGROUND: The association between coffee/tea intake and hypertensive disorders of pregnancy (HDP) remains unclear. This study aimed to investigate the association of caffeine, coffee, and tea intake during pregnancy with the risk of HDP. METHODS: We assessed this association in 85,533 singleton pregnant women with live births in the Japan Environment and Children's Study, a prospective cohort in Japan that included women from early pregnancy onward. Caffeinated and decaffeinated coffee and tea (green, oolong, and black) consumption during pregnancy was assessed using a validated food frequency questionnaire conducted at mid-pregnancy, and caffeine intake was calculated based on coffee and tea consumption. Multivariable logistic regression was used to assess the association with the risk of HDP. RESULTS: HDP developed in 2222 women (2.6%). Caffeine intake was weakly associated with increased risk of HDP; the multivariable odds ratio of HDP for the highest versus the lowest quartile was 1.26 (95% confidence interval: 1.11, 1.43). Coffee drinkers of two or more cups per day showed a decreased risk compared with non-drinkers (multivariable odds ratio 0.79; 0.62, 0.99) even after adjustment for total caffeine intake. Tea consumption was not associated with the risk of HDP. CONCLUSIONS: Our study suggests that higher caffeine intake may increase HDP risk, while coffee drinkers had a lower risk. Further high-quality studies are needed to replicate these findings, and to elucidate if other substances in coffee may be protective against HDP.
• Association between maternal employment status during pregnancy and risk of depressive symptomatology 1 month after childbirth: the Japan Environment and Children's Study.

  Yuri Aochi, Kaori Honjo, Takashi Kimura, Satoyo Ikehara, Hiroyasu Iso

  Journal of epidemiology and community health 75 (6) 531 - 9 2021/01/19 [Refereed][Not invited]
   

  BACKGROUND: Previous studies, which examined the association between employment status and postpartum depression, were limited by binary or ternary employment status measures (employed/unemployed or full-time/part-time/unemployed). This study examined the association between detailed employment status during pregnancy and risk of depressive symptomatology 1 month after childbirth, and the effect modification by one's perceived level of social support and household equivalent income. METHODS: Our study examined 76 822 participants in the Japan Environment and Children's Study. The exposure included maternal employment status during pregnancy (regular workers, dispatched workers, part-time workers, self-employed workers, non-employed and others), and the outcome was depressive symptomatology 1 month after childbirth: Edinburgh Postnatal Depression Scale (EPDS scores ≥9 and ≥13). Adjusted ORs and 95% CIs of depressive symptomatology associated with employment status were calculated by multivariable logistic regression. Subgroup analyses by perceived level of social support and household equivalent income were conducted. RESULTS: Compared with regular workers, the risk of depressive symptomatology (EPDS score ≥9) was higher for non-employed and others, and that (EPDS score ≥13) was so for part-time workers. There was no significant interaction by perceived level of social support and household equivalent income in the associations. However, part-time workers and non-employed had excess risk of depressive symptomatology among women with lower perceived level of social support, but not among those with the higher one. CONCLUSION: Compared with regular workers, part-time workers and non-employed had an increased risk of depressive symptomatology, which was confined to women with lower perceived level of social support.
• Association between Protein Intake and Skeletal Muscle Mass among Community-Dwelling Older Japanese: Results from the DOSANCO Health Study: A Cross-Sectional Study.

  Akinori Yaegashi, Takashi Kimura, Takumi Hirata, Shigekazu Ukawa, Koshi Nakamura, Emiko Okada, Takafumi Nakagawa, Akihiro Imae, Akiko Tamakoshi

  Nutrients 13 (1) 187 - 187 2021/01/09 [Refereed][Not invited]
   

  Whether the source of dietary protein intake is related to appendicular skeletal muscle mass (AMM) and muscle mass (MM) remains unclear. We conducted this cross-sectional study of 277 residents (115 men, 162 women) aged ≥65 years in Japan to examine the association of the amount of dietary protein intake with AMM and MM. We measured dietary protein intake using a brief self-administered diet history questionnaire. AMM and MM were assessed based on bioelectrical impedance. Multivariable linear regression analyses were used to estimate β coefficients that were adjusted for potential confounders. Among Japanese women aged ≥75 years, but not among women aged 65-74 years, dietary animal protein intake was significantly associated with AMM (β (95% confidence interval (CI)): 0.25 (0.10, 0.40)) and MM (β (95% CI): 0.40 (0.16, 0.64)). However, dietary vegetable protein intake was not associated with AMM (β (95% CI): -0.17 (-0.74, 0.41)) and MM (β (95% CI): -0.30 (-1.23, 0.63)). Furthermore, in men aged ≥65 years, dietary protein intake was not associated with AMM or MM. In conclusion, dietary animal protein intake, but not vegetable protein intake, were positively associated with AMM and MM among this population of Japanese women aged ≥75 years.
• Effective vaccine allocation strategies, balancing economy with infection control against COVID-19 in Japan.

  Satoshi Sunohara, Toshiaki Asakura, Takashi Kimura, Shun Ozawa, Satoshi Oshima, Daigo Yamauchi, Akiko Tamakoshi

  PloS one 16 (9) e0257107  2021 [Refereed][Not invited]
   

  Due to COVID-19, many countries including Japan have implemented a suspension of economic activities for infection control. It has contributed to reduce the transmission of COVID-19 but caused severe economic losses. Today, several promising vaccines have been developed and are already being distributed in some countries. Therefore, we evaluated various vaccine and intensive countermeasure strategies with constraint of economic loss using SEIR model to obtain knowledge of how to balance economy with infection control in Japan. Our main results were that the vaccination strategy that prioritized younger generation was better in terms of deaths when a linear relationship between lockdown intensity and acceptable economic loss was assumed. On the other hand, when a non-linearity relationship was introduced, implying that the strong lockdown with small economic loss was possible, the old first strategies were best in the settings of small basic reproduction number. These results indicated a high potential of remote work when prioritizing vaccination for the old generation. When focusing on only the old first strategies as the Japanese government has decided to do, the strategy vaccinating the young next to the old was superior to the others when a non-linear relationship was assumed due to sufficient reduction of contact with small economic loss.
• Social support, social cohesion and pain during pregnancy: The Japan Environment and Children's Study.

  Keiko Yamada, Takashi Kimura, Meishan Cui, Yasuhiko Kubota, Satoyo Ikehara, Hiroyasu Iso

  European journal of pain (London, England) 25 (4) 872 - 885 2020/12/20 [Refereed][Not invited]
   

  BACKGROUND: Persistent pain during pregnancy is a significant health issue, which could be correlated with psychological distress resulting from inadequate social support. This study aims to investigate whether the relationship between poor social support and antenatal pain is mediated by psychological distress. We also aimed to examine whether social cohesion moderates the influence of psychological distress on the relationship between social support and antenatal pain. METHODS: We analysed 94,517 pregnancies of women from a Japanese national birth cohort completed questionnaires assessing pain, psychological distress, social support and social cohesion. Psychological distress was assessed using the Kessler Psychological Distress Scale. Two types of models were used: the mediation model to examine whether the association between social support and pain was mediated by psychological distress; the moderated mediation model to analyse whether social cohesion buffered the negative effect of inadequate social support on pain. Demographic, socioeconomic and psychological factors were controlled for in all analyses. RESULTS: Psychological distress was fully mediated the association between social support and pain. Social cohesion had a focal moderation effect on the inverse association between social support and psychological distress (unstandardized regression coefficient [β] = 0.09; 95% CI, 0.07-0.11) and functioned as moderator for the indirect effect of social support on antenatal pain (index of moderated mediation = 0.006; 95% CI, 0.004-0.007). CONCLUSIONS: Poor social support was related to antenatal pain through psychological distress, possibly buffered by social cohesion. During the antenatal period, social support and cohesion are important for women. SIGNIFICANCE: In this study, poor social support was found to be associated with pain intensity during pregnancy, which was mediated by psychological distress and might be buffered by desirable social cohesion. This finding could potentially help healthcare providers and policy makers to understand the importance of desirable social cohesion in preventing pain among pregnant women.
• Association between accelerometer-measured physical activity and falls among community-dwelling older people living in cold, snowy areas.

  Reiji Kojima, Shigekazu Ukawa, Hiroshi Yokomichi, Aya Tanaka, Takashi Kimura, Shiho Amagasa, Shigeru Inoue, Katsunori Kondo, Akiko Tamakoshi

  European geriatric medicine 12 (1) 91 - 98 2020/09/25 [Refereed][Not invited]
   

  PURPOSE: The aim of the present study was to investigate the association between falls, including falls on frozen roads, and physical activity among older people living in cold, snowy regions in Japan. METHODS: Participants were subjects of the Japan Gerontological Evaluation Study 2016 who had agreed to the Hokkaido additional visit survey in winter 2017/18 and lived in cold, snowy regions in Japan. The analysis included 461 participants (mean age 74.7 years; standard deviation 2.8 years; 46.5% male). Sociodemographic characteristics, physical activity (min/day of moderate-to-vigorous intensity physical activity [MVPA] and light intensity physical activity, and walking steps/day) measured by accelerometer, cognitive function, depression, visual impairment, and history of stroke were surveyed. Poisson regression analyses were performed to clarify the association between prevalence of falls and physical activity. RESULTS: Of those who reported a fall with location, 86 (69.9%) fell on frozen roads, 24 (19.5%) fell on unfrozen roads and 13 (10.6%) fell indoors. There were significant positive associations between MVPA (adjusted prevalence ratio [aPR] Tertile [T] 3 vs T1, 1.73; 95% confidence interval [CI], 1.04-2.87) and all falls. When limited to falls on frozen roads, higher MVPA levels and walking steps were associated with falls on frozen roads (MVPA, aPR T3 vs T1, 2.16; 95% CI, 1.19-3.94; walking steps, aPR T3 vs T1, 2.49; 95%CI 1.33-4.68). CONCLUSION: The risk of falls, especially on frozen roads, increased among active older people living in cold, snowy regions, and environmental factors should be considered when determining prevention strategies.
• Are Japanese women less physically active than men? Findings from the DOSANCO Health Study.

  Shiho Amagasa, Shigeru Inoue, Shigekazu Ukawa, Sachiko Sasaki, Koshi Nakamura, Aya Yoshimura, Aya Tanaka, Takashi Kimura, Takafumi Nakagawa, Akihiro Imae, Ding Ding, Hiroyuki Kikuchi, Akiko Tamakoshi

  Journal of epidemiology 31 (10) 530 - 536 2020/08/08 [Refereed][Not invited]
   

  BackgroundPrevious research has established that women accumulate less moderate-to-vigorous physical activity (MVPA) than men. To date, however, little is known about the gender differences in device-based activity patterns of sedentary behavior (SB) and light-intensity physical activity (LPA). We aimed to compare time spent in SB and different intensities of physical activity taking into account of co-dependence of time use domains.MethodsThis cross-sectional study was conducted in Suttu town, Hokkaido, Japan. Data were analyzed from 634 Japanese adults (278 men, aged 19-92 years) who provided valid accelerometer (HJA-750C) data. Gender differences in activity behavior patterns were tested by multivariate analysis of covariance (MANCOVA) based on isometric log-ratio transformations of time use, adjusting for age. We also developed bootstrap percentile confidence intervals (CI) to support the interpretation of which behavior differed between genders.ResultsOverall, participants had percent time spent in SB, LPA, MVPA during wearing time (mean 14.8 hours) corresponding to 53.9%, 41.7%, and 4.4%, respectively. Activity behavior patterns differed significantly between genders after controlling for time spent in all activities. Women spent relatively 13.3% (CI: 9.9, 15.9) less time in SB and 19.8% (CI: 14.9, 24.6) more time in LPA compared to men. The difference of time spent in MVPA was not statistically significant.ConclusionsIn contrast with previous studies, our findings suggest that Japanese women are more physically active than men when all intensities of activities are considered. Given the health benefits of LPA, evaluating only MVPA may disproportionately underestimate the level of physical activity of women.
• Soy consumption and incidence of gestational diabetes mellitus: the Japan Environment and Children's Study.

  Jia-Yi Dong, Takashi Kimura, Satoyo Ikehara, Meishan Cui, Yoko Kawanishi, Tadashi Kimura, Kimiko Ueda, Hiroyasu Iso

  European journal of nutrition 60 (2) 897 - 904 2020/06/06 [Refereed][Not invited]
   

  BACKGROUND: Intervention studies have shown that isoflavone treatment improved glucose metabolism, indicating that soy intake may have a potential role in diabetes prevention. OBJECTIVES: We aimed to investigate the prospective association of soy isoflavone and soy food intakes with incidence of gestational diabetes mellitus (GDM) in a birth cohort study. METHODS: We recruited 97,454 pregnant women (median gestational age 12 weeks) between January 2011 and March 2014. Dietary intakes during the 12 months preceding study enrollment were assessed by a semi-quantitative food frequency questionnaire. The relative risks of GDM associated with soy isoflavone and soy food intakes were obtained by Poisson regression. Demographic information, histories of diseases, socioeconomic status, lifestyles, and dietary habits, obtained by a self-administrated questionnaire, were used for covariate adjustments. RESULTS: We identified 1904 cases of GDM (2.2%) among 84,948 women. Compared with those in the lowest quintile of soy isoflavone intake, women in the highest quintile were found to have experienced a significantly lower risk of GDM (multivariate relative risk = 0.82; 95% confidence interval: 0.70, 0.95; P for trend = 0.05). Similar results were observed for genistein and daidzein. Regarding soy foods, intakes of miso soup and natto were inversely associated with GDM incidence (both P for trend ≤ 0.01), whereas the association for tofu intake appeared to be nonlinear (P for trend = 0.74). CONCLUSIONS: Higher intakes of miso soup and natto before and during early pregnancy, compared with lower intakes, may be associated with a lower incidence of GDM.
• Self-Reported Eating Speed and Incidence of Gestational Diabetes Mellitus: the Japan Environment and Children's Study.

  Jia-Yi Dong, Satoyo Ikehara, Takashi Kimura, Meishan Cui, Yoko Kawanishi, Tadashi Kimura, Kimiko Ueda, Hiroyasu Iso, The Japan Environment And Children's Study Group

  Nutrients 12 (5) 2020/05/02 [Refereed][Not invited]
   

  There is little evidence linking eating speed to gestational diabetes mellitus (GDM) incidence. We therefore aimed to evaluate the prospective association of eating speed with GDM incidence. Overall, 97,454 pregnant women were recruited between January 2011 and March 2014. Singleton pregnant women who did not have GDM, heart disease, stroke, cancer, type 1 diabetes, and/or type 2 diabetes at the time of study enrollment were eligible. Each woman was asked about her eating speed at that time via a questionnaire. Odds ratios of GDM in relation to eating speed were obtained using logistic regression. Among the 84,811 women eligible for analysis, 1902 cases of GDM were identified in medical records. Compared with women who reported slow eating speed, the age-adjusted odds ratios (95% confidence interval) of GDM for women who reported medium, relatively fast, or very fast eating speed were 1.03 (0.90, 1.18), 1.07 (0.94, 1.23), and 1.28 (1.05, 1.58), respectively. Adjustment for demographic, lifestyle-related, and dietary factors including dietary fat, dietary fiber, and energy intakes yielded similar results. The association was attenuated and no longer significant after further adjustment for pre-pregnancy body mass index. The mediation analysis showed that being overweight accounted for 64% of the excess risk of GDM associated with eating speed. In conclusion, women who reported very fast eating speed, compared with those reporting slow eating speed, were associated with an increased incidence of GDM, which may be largely mediated by increased body fat.
• Maternal total energy, macronutrient and vitamin intakes during pregnancy associated with the offspring's birth size in the Japan Environment and Children's Study.

  Ehab S Eshak, Chika Okada, Sachiko Baba, Takashi Kimura, Satoyo Ikehara, Takuyo Sato, Kokoro Shirai, Hiroyasu Iso

  The British journal of nutrition 124 (6) 1 - 26 2020/04/21 [Refereed][Not invited]
   

  Maternal diet during pregnancy can influence foetal growth; however, the available evidence is controversial. We aimed to assess whether maternal diet of Japanese women in mid-pregnancy can affect their offspring's birth size via collection of questionnaire and medical record data. The studied sample was a large cohort of paired mothers and their singleton offspring (n= 78,793) from 15 areas allover Japan who participated in the Japan Environment and Children's Study (JECS).The mid-pregnancy intakes of total energy, macronutrients and vitamins were lower than the recommended intakes for pregnant Japanese women. Maternal total energy intake was positively associated with the offspring's birth weight; 10-g mean difference in the offspring's birth weight of mothers in the lowest (3,026 g) versus highest (3,036 g) quartiles of energy intake. Carbohydrate intake was positively associated with the offspring's birth length (mean difference of 0.7 cm) and inversely associated with the ponderal index (mean difference of 0.8 g/cm3). Offspring of mothers in the highest versus lowest quartiles of total dietary fiber intake were on average 9 g heavier and had 0.3 cm longer birth length and 0.2 cm longer head circumference. The highest in reference to lowest intake quartile of vitamin C was associated with 13 g and 0.7 cm mean differences in the offspring's birth weight and length respectively. Several other associations were evident for maternal vitamins intakes and the offspring's birth size.In conclusion, maternal dietary intakes of energy, dietary fiber, carbohydrate and vitamins during pregnancy were associated with the offspring's birth size.
• Skipping breakfast before and during early pregnancy and incidence of gestational diabetes mellitus: the Japan Environment and Children's Study.

  Jia-Yi Dong, Satoyo Ikehara, Takashi Kimura, Meishan Cui, Yoko Kawanishi, Tadashi Kimura, Kimiko Ueda, Hiroyasu Iso

  The American journal of clinical nutrition 111 (4) 829 - 834 2020/04/01 [Refereed][Not invited]
   

  BACKGROUND: There is little evidence linking breakfast skipping to the incidence of gestational diabetes mellitus (GDM). OBJECTIVES: We aimed to evaluate the prospective association of breakfast consumption with the incidence of GDM. METHODS: A total of 103,099 pregnancies were registered during study enrollment (January 2011 to March 2014), involving 97,454 pregnant women from 15 areas across Japan. Singleton pregnant women free of GDM, stroke, heart disease, cancer, and type 1 or type 2 diabetes at the study enrollment were eligible for analysis. We used a self-administered questionnaire to obtain data on demographic information, socioeconomic status, self-rated health status, disease history, lifestyle, and dietary habits of each woman at study enrollment. A semiquantitative FFQ was used for dietary assessment. We used logistic regression to obtain the OR of GDM in relation to breakfast consumption. RESULTS: Among 84,669 pregnant women for analysis, 1935 cases of GDM were documented. After adjustment for potential confounding factors including prepregnancy BMI, the multivariable-adjusted ORs of GDM for women who consumed breakfast 5-6 times/wk, 3-4 times/wk, and 0-2 times/wk were 1.09 (95% CI: 0.93, 1.27), 1.14 (95% CI: 0.96, 1.34), and 1.21 (95% CI: 1.05, 1.41), respectively, compared with daily breakfast eaters. The association appeared to be dose dependent (P-trend = 0.006) and was not significantly modified by prepregnancy BMI. CONCLUSIONS: Breakfast consumption <3 times/wk before and during early pregnancy, compared with daily consumption, was associated with an increased odds of developing GDM.
• Pain medications during pregnancy: data from the Japan environment and children's study.

  Keiko Yamada, Takashi Kimura, Satoyo Ikehara, Meishan Cui, Yasuhiko Kubota, Kenta Wakaizumi, Takashi Takeda, Hiroyasu Iso

  Journal of anesthesia 34 (2) 202 - 210 0913-8668 2020/04 [Refereed][Not invited]
   

  PURPOSE: Analgesic medication epidemic during pregnancy is an important issue in Western countries. However, no large epidemiological study involving pregnant women with pain and their medication use has been conducted in Japan. This study examined the current situation of medication use for non-cancer pain during the perinatal period in Japan using national cohort data. METHODS: We analyzed 94,649 pregnant women who completed a self-report questionnaire investigating bodily pain and an interview-based medication use survey. Medication use before and during pregnancy and new medication administration/discontinuation during pregnancy were compared between women with and without pain during pregnancy using multivariable covariance analysis. RESULTS: Mild pain was reported by 50.4% of pregnant women in the first trimester (survey 1) and 61.8% in the second/third trimester (survey 2). Moderate-to-severe pain was reported by 15.4% of women in survey 1 and 22.4% in survey 2. In survey 1, 6.2% of women used prescribed analgesics and 1.6% used over-the-counter analgesics. In survey 2, prescribed and over the counter analgesics were used by 12.2% and 0.8% of women, respectively. Other pain-related medications were rarely used (< 1.0%). Pregnant women with moderate-to-severe pain showed a lower proportion of discontinuation of analgesics and a higher proportion of new administration of prescription and transdermal analgesics compared with those without pain. CONCLUSIONS: Although a large proportion of pregnant women experience pain, medication use for pain during pregnancy is low in Japan compared with Western countries (50-60%). Adequate treatment or support may be necessary for pregnant women experiencing pain in Japan.
• Prenatal tobacco smoking is associated with postpartum depression in Japanese pregnant women: The japan environment and children's study.

  Meishan Cui, Takashi Kimura, Satoyo Ikehara, Jia-Yi Dong, Kimiko Ueda, Yoko Kawanishi, Tadashi Kimura, Hiroyasu Iso

  Journal of affective disorders 264 76 - 81 0165-0327 2020/03/01 [Refereed][Not invited]
   

  INTRODUCTION: Previous studies in Western countries have examined the association between prenatal smoking and risk for Postpartum depression (PPD). However, evidence from Japan is lacking, despite the high prevalence of smoking among pregnant women. Therefore, we examined the association between prenatal smoking and PPD among pregnant Japanese women. METHODS: We analyzed data for up to 1 month after childbirth from the Japan Environment and Children's Study (JECS), a nationwide birth cohort study. Among the 103,070 pregnant women recruited, 80,872 eligible participants were included in the analysis. PPD was defined as a score of ≥9 on the Edinburgh Postnatal Depression Scale (EPDS). Prenatal smoking and length of smoking cessation among ex-smokers were obtained using self-administered questionnaires at second/third trimester. RESULTS: Among 80,872 pregnant women, 9.0% reported PPD. Multivariable-adjusted odds ratios (OR) (95% confidence intervals) for PPD (reference: never smoked) were 1.24 (1.12-1.37) for women who quit smoking after becoming pregnant, and 1.38 (1.21-1.56) for those who smoked during pregnancy. Compared with women who had never smoked, those who quit smoking ≤5 years before childbirth had a higher occurrence of PPD, with a multivariable-adjusted OR of 1.10 (1.00-1.22). LIMITATIONS: Questionnaire data was self-reported by participants, thus smoking status might be under-reported. CONCLUSIONS: Women who smoked during pregnancy, quit smoking after becoming pregnant, and quit smoking ≤5 years before childbirth are more likely to experience PPD than those who had never smoked.
• Impact of intention and feeling toward being pregnant on postpartum depression: the Japan Environment and Children’s Study (JECS)

  Sachiko Baba, Takashi Kimura, Satoyo Ikehara, Kaori Honjo, Ehab S. Eshak, Takuyo Sato, Hiroyasu Iso, Toshihiko Kawamoto, Hirohisa Saito, Reiko Kishi, Nobuo Yaegashi, Koichi Hashimoto, Chisato Mori, Shuichi Ito, Zentaro Yamagata, Hidekuni Inadera, Michihiro Kamijima, Takeo Nakayama, Masayuki Shima, Yasuaki Hirooka, Narufumi Suganuma, Koichi Kusuhara, Takahiko Katoh

  Archives of Women's Mental Health 23 (1) 131 - 137 1434-1816 2020/02/01 [Refereed][Not invited]
   

  © 2018, The Author(s). Pregnancy intention is reported to be associated with the risk of postpartum depression (PPD), but the impact of feelings toward being pregnant on PPD is unknown. We aimed to examine whether feelings toward being pregnant are associated with PPD at 1 month after childbirth. In our nationwide study between 2011 and 2014 in Japan, we used multivariate logistic regression analyses to examine the associations between pregnancy intention and feelings toward being pregnant with PPD [Edinburgh Postnatal Depression Scale (EPDS score > 9 or > 12)] among Japanese women. Among 92,431 women, 14.0 and 5.4% had PPD with EPDS scores > 9 and > 12, respectively. Compared with women who felt very happy to be pregnant, those whose pregnancy was unintended but happy, unintended and confused, those who felt troubled, and those who felt no emotion toward being pregnant had increased risks of PPD [multivariable odds ratios (95% confidence intervals (CIs)) = 1.17 (1.11–1.22), 1.39 (1.29–1.49), 1.74 (1.42–2.14), and 1.58 (1.22–2.02), respectively, for EPDS score > 9]. Those associations were more evident without antenatal possible mental illness (K6 score < 13). Women whose pregnancy was unintended should be regarded as targets for the early detection and prevention of PPD irrespective of whether they felt happy or confused.
• Associations Between Broader Autism Phenotype and Dietary Intake: A Cross-Sectional Study (Japan Environment & Children's Study).

  Kumi Hirokawa, Takashi Kimura, Satoyo Ikehara, Kaori Honjo, Kimiko Ueda, Takuyo Sato, Hiroyasu Iso

  Journal of autism and developmental disorders 50 (8) 2698 - 2709 2020/01/29 [Refereed][Not invited]
   

  The purpose of the present study was to investigate associations of dietary intake including vitamin D, folate, and n-3 and n-6 polyunsaturated fatty acids (PUFA) in pregnant women with broad autism phenotype (BAP). The Japan Environment and Children's Study is a government-funded birth cohort study. All complete data of 92,011 were analyzed. The Japanese version of the Autism Spectrum Quotient was used to assess mothers' BAP level, and a food frequency questionnaire was used to estimate their dietary intake. Mothers with BAP consumed less vegetables, fruits, and fish and shellfish, and they consumed lower folate, vitamin C, vitamin D, and n-3 PUFA than their counterparts. Dietary intervention should be considered for pregnant women with high BAP scores.
• Associations of gut microbiota, dietary intake, and serum short-chain fatty acids with fecal short-chain fatty acids.

  Ryodai Yamamura, Koshi Nakamura, Naoya Kitada, Tomoyasu Aizawa, Yu Shimizu, Kiminori Nakamura, Tokiyoshi Ayabe, Takashi Kimura, Akiko Tamakoshi

  Bioscience of microbiota, food and health 39 (1) 11 - 17 2020 [Refereed][Not invited]
   

  In recent years, short-chain fatty acids (SCFAs) have been reported to play an important role in maintaining human health. Fecal SCFA concentrations correlate well with colonic SCFA status and gut microbiota composition. However, the associations with the gut microbiota functional pathway, dietary intake, blood SCFAs, and fecal SCFAs remain uncertain. To clarify these relationships, we collected fecal samples, blood samples, and dietary habit data from 12 healthy adults aged 22-51 years. The relative abundance of several SCFA-producing bacteria, gut microbiota diversity, and functional pathways related to SCFA biosynthesis were positively associated with fecal SCFAs even after adjusting for age and sex. Furthermore, fecal acetate was likely to be positively associated with serum acetate. By contrast, dietary intake was not associated with fecal SCFAs. Overall, the present study highlights the potential usefulness of fecal SCFAs as an indicator of the gut microbiota ecosystem and dynamics of SCFAs in the human body.
• Relationships between reproductive history and mortality from cardiovascular diseases among Japanese women: the Japan Collaborative Cohort (JACC) Study.

  Kanami Tanigawa, Satoyo Ikehara, Takashi Kimura, Hironori Imano, Isao Muraki, Kokoro Shirai, Akiko Tamakoshi, Hiroyasu Iso

  Journal of epidemiology 30 (11) 509 - 515 0917-5040 2019/11/16 [Refereed][Not invited]
   

  BACKGROUND: Reproductive history has been addressed as a risk factor for cardiovascular disease (CVD). We examined the relationship between reproductive history and CVD mortality in Japanese women. METHODS: We followed 53,836 women without previous CVD or cancer history from 1988-1990 to 2009 in a prospective cohort study. Hazard ratios (HRs) of CVD mortality were estimated according to the number of deliveries and maternal age at first delivery. RESULTS: During the follow-up, 2,982 CVD-related deaths were identified. There was U-shaped association between the number of deliveries and risk of CVD mortality with reference to three deliveries, although the excess risk of CVD mortality associated with ≥5 deliveries was of borderline statistical significance. The corresponding multivariable HRs (95% CIs) were 1.33 (1.12-1.58) and 1.11 (0.99-1.24). In addition, a higher CVD mortality was associated with maternal age ≥28 years at first delivery than maternal age of 24-27 years at first delivery. The multivariable HRs were 1.22 (1.10-1.36) for 28-31, and 1.26 (1.04-1.52) for ≥32 years at first delivery. Moreover, among women with ≥3 deliveries, maternal age ≥28 years at first delivery was associated with 1.2- to 1.5-fold increased CVD mortality. CONCLUSION: The number of deliveries showed a U-shaped association with risk of CVD mortality. Higher maternal age at first delivery was associated with an increased risk of CVD mortality, and excessive risk in women aged ≥28 years at first delivery was noted in those with ≥3 deliveries.
• Chocolate consumption and risk of gestational diabetes mellitus: the Japan Environment and Children's Study.

  Jia-Yi Dong, Takashi Kimura, Satoyo Ikehara, Meishan Cui, Yoko Kawanishi, Kazumasa Yamagishi, Kimiko Ueda, Hiroyasu Iso

  The British journal of nutrition 122 (8) 936 - 941 0007-1145 2019/10/28 [Refereed][Not invited]
   

  The association of chocolate consumption with risk of gestational diabetes has not been examined. We aimed to investigate the prospective association between chocolate consumption and risk of gestational diabetes in a large birth cohort in Japan. A total of 97 454 pregnant women with a median gestational age of 12 weeks were recruited from January 2011 to March 2014. Data on demographic information, disease history, socio-economic status, lifestyle and dietary habits were obtained at the study enrolment. Dietary intake during the past 12 months before study enrolment was assessed through a semi-quantitative FFQ. The logistic regression was used to obtain the OR of gestational diabetes in relation to chocolate consumption. Among 84 948 women eligible for the analysis, 1904 cases of gestational diabetes (2·2 %) were identified during the period of pregnancy. After controlling for potential confounding factors including age, smoking status, drinking status, education level, occupation, pre-pregnant BMI, depression, previous history of macrosomia babies, parity, physical activity and dietary factors, women in the highest quartile of chocolate consumption, compared with those in the lowest quartile, had a significantly lower risk of developing gestational diabetes (OR 0·78, 95 % CI 0·67, 0·90; P for trend = 0·002). Stratified analyses suggested that the association was not significantly modified by pre-pregnancy BMI, age, parity, smoking status or drinking status. The present prospective cohort study provided evidence that chocolate consumption was associated with a significant lower risk of gestational diabetes in Japanese women.
• Association between maternal alcohol consumption during pregnancy and risk of preterm delivery: the Japan Environment and Children's Study.

  Ikehara S, Kimura T, Kakigano A, Sato T, Iso H, Japan Environment Children's Study Group

  BJOG : an international journal of obstetrics and gynaecology 126 (12) 1448 - 1454 1470-0328 2019/08 [Refereed][Not invited]
  
• Associations between broader autism phenotype (BAP) and maternal attachment are moderated by maternal postpartum depression when infants are one month old: A prospective study of the Japan environment & children's study.

  Kumi Hirokawa, Takashi Kimura, Satoyo Ikehara, Kaori Honjo, Takuyo Sato, Kimiko Ueda, Hiroyasu Iso

  Journal of affective disorders 243 485 - 493 0165-0327 2019/01/15 [Refereed][Not invited]
   

  BACKGROUND: Broader autism phenotype (BAP) refers to the expression of behavioral and cognitive dispositions similar to autism spectrum disorder. The present study investigated whether mothers' BAP was prospectively associated with maternal attachment, and if postpartum depression modified this association. METHODS: The Japan Environment and Children's Study (JECS) is a national and government-funded birth cohort study that began in January 2011. Among the 103,099 mothers enrolled, 87,369 mothers without a history of depression were included in the analysis. Self-administered questionnaires were used. These included: the Japanese version of the Autism Spectrum Quotient, the Mother to Infant Bonding Scale, and the Edinburgh Postnatal Depression Scale. Logistic regression analyses were performed. RESULTS: The BAP during the second or third trimester of pregnancy was linearly associated with an increased risk of postpartum depression and insecure maternal attachment when infants were one month old (p for trend < 0.001), after adjusting for confounding variables. When stratified by postpartum depression, among the BAP subscales, deficiencies in social skills and communication were associated with an increased risk of insecure maternal attachment in mothers without postpartum depression. The relationships between the BAP subscales and maternal attachment were attenuated among mothers with postpartum depression. LIMITATIONS: Only five items of the Mother to Infant Bonding Scale were used in the present study, and thus the results should be interpreted with caution. CONCLUSIONS: Mothers' BAP was predictive of insecure maternal attachment toward their infant. Postpartum depression partially moderated the associations between mothers' BAP and insecure maternal attachment.
• Association between family members and risk of postpartum depression in Japan: Does “who they live with” matter? -The Japan environment and Children's study

  Kaori Honjo, Takashi Kimura, Sachiko Baba, Satoyo Ikehara, Naomi Kitano, Takuyo Sato, Hiroyasu Iso, Reiko Kishi, Nobuo Yaegashi, Koichi Hashimoto, Chisato Mori, Shuichi Ito, Zentaro Yamagata, Hidekuni Inadera, Michihiro Kamijima, Toshio Heike, Hiroyasu Iso, Masayuki Shima, Yasuaki Kawai, Narufumi Suganuma, Koichi Kusuhara, Takahiko Katoh

  Social Science and Medicine 217 65 - 72 0277-9536 2018/11 [Refereed][Not invited]
   

  © 2018 Elsevier Ltd There are many psychosocial and biomedical risk factors for postpartum depression (PPD). However, associations between co-resident family members and PPD risk have not been examined. This study investigated whether co-resident family members were associated with risk for PPD during 1 month postpartum among Japanese women, and if these associations were modified by household income and their perceived partner's involvement in childcare. The sample comprised 86,490 women. Data were drawn from the Japan Environment and Children's Study, a large-scale national cohort study started in 2011. Our major predictor was co-resident family members when they registered around the first trimester of the women's pregnancy: partner, parent(s), parent(s)-in-law, or child(ren). The outcome was PPD at 1 month after delivery, assessed by the Edinburgh Postnatal Depression Scale. Adjusted odds ratios (OR) for family members and PPD incidence were calculated using multivariable logistic regression analysis. Subgroup analyses were conducted by household income and perceived partner's involvement in childcare. Adjusted ORs (95% confidence interval) for PPD for those not living with their partner, parent(s), parent(s)-in-law, or child(ren) compared with those who lived with these family members were 1.21 (1.07–1.37), 1.13 (1.03–1.24), 0.91 (0.84–0.98), and 1.42 (1.31–1.53), respectively. The level of perceived partner's involvement in childcare changed the identified association between family member and PPD. We found that “who a pregnant woman lives with” affects the risk of PPD in the first month postpartum, and high levels of perceived partner's involvement in childcare reduced harmful effects/increased protective effect of family members on PPD incidence. These findings suggested that interventions to increase perceived partner's support for childcare may be effective in preventing PPD, regardless of living situation.
• Educational Levels and Risk of Suicide in Japan: The Japan Public Health Center Study (JPHC) Cohort I

  Takashi Kimura, Hiroyasu Iso, Kaori Honjo, Satoyo Ikehara, Norie Sawada, Motoki Iwasaki, Shoichiro Tsugane

  JOURNAL OF EPIDEMIOLOGY 26 (6) 315 - 321 0917-5040 2016/06 [Refereed][Not invited]
   

  Background: Suicide rates have been related to educational level and other socioeconomic statuses. However, no prospective study has examined the association between educational level and the risk of suicide in Japan. Methods: We examined the association of education level and suicide risk in a population-based cohort of Japanese men and women aged 40-59 years in the Japan Public Health Center-based Prospective Study Cohort I. In the baseline survey initiated in 1990, a total of 46 156 subjects (21 829 men and 24 327 women) completed a self-administered questionnaire, which included a query of educational level, and were followed up until the end of December 2011. Educational levels were categorized into four groups (junior high school, high school, junior or career college, and university or higher education). During a median follow-up of 21.6 years, the hazard ratios (HRs) and 95% confidence intervals (CIs) of suicide according to educational level were estimated using the Cox proportional hazards regression model adjusted for age; study area; previous history of stroke, ischemic heart disease, or cancer; self-reported stress; alcohol consumption; smoking; living with spouse; and employment status. A total of 299 deaths attributed to suicide occurred. Results: The HR for university graduates or those with higher education versus junior high school graduates was 0.47 (95% CI, 0.24-0.94) in men, and that for high school graduates versus junior high school graduates was 0.44 (95% CI, 0.24-0.79) in women. Conclusions: High educational levels were associated with a reduced risk of suicide for both Japanese men and women.

MISC

• 意図せぬ自然妊娠・不妊治療を経た妊娠期・子育早期における男性のメンタルヘルスリスクについて

  水沼 直樹, 黒崎 久仁彦, 山田 恵子, 木村 尚史, 上田 豊, 武田 卓, 田淵 貴大  東邦医学会雑誌  70-  (4)  167  -167  2023/12
• 意図せぬ自然妊娠・不妊治療を経た妊娠期・子育早期における男性のメンタルヘルスリスクについて

  水沼 直樹, 黒崎 久仁彦, 山田 恵子, 木村 尚史, 上田 豊, 武田 卓, 田淵 貴大  東邦医学会雑誌  70-  (4)  167  -167  2023/12
• 「母親の授乳期の食事・母乳栄養成分・乳児の発育」の関連性 岩見沢母子健康調査(SMILE Iwamizawa)における産後1ヵ月時点の解析

  小松 陽介, 和田 泰明, 田畑 風華, 川上 智美, 武田 安弘, 中村 公則, 綾部 時芳, 中村 幸志, 木村 尚史, 玉腰 暁子  DOHaD研究  11-  (3)  30  -30  2023/08
• 妊娠期における父親のパートナーに対する関わりとボンディング障害の関連

  田中 嘉き, 岡田 恵美子, 平田 匠, 木村 尚史, 玉腰 暁子  日本公衆衛生雑誌  70-  (6)  359  -368  2023/06  

  目的 親が子どもに対して抱く情緒的絆の欠如をボンディング障害という。本研究では妊娠期の父親のパートナーへの関わりとボンディング障害の関連を検討する。方法 2016年5月～2017年12月に札幌市内の3つの産科病院を受診した妊婦とそのパートナー1,957組を対象とした。自記式質問票を妊娠24～35週と産後6～8週後に配布した。父親のパートナーへの関わりは,身の回りのことや家事の手伝い,相談にのっているかという2つの質問項目の5択の回答を0～4点で評価し,合計点が6～8点を高得点群,3～5点を中得点群,0～2点を低得点群とした。ボンディング障害は「赤ちゃんへの気持ち質問票」を用い,程度が高い上位約10%が含まれる点数をカットオフ値とした。妊娠期の父親のパートナーへの関わりを曝露,アウトカムをボンディング障害とし,ロジスティック回帰分析を行った。調整変数は父親の年齢,世帯年収,父親の一週間の平均労働時間,過去の妊娠,過去の流産や死産・子どもの死亡,パートナーの妊娠期抑うつとした。結果 回答を得られた父親は391人であり2回目の回答記入時期は産後2か月までが86.4%,3か月が10.6%,4か月が2.5%,5か月が1.0%であった。そのうち質問項目が欠損した者を除く375人を対象とした。父親のパートナーへの関わり高得点群は255人(68.0%),ボンディング障害は48人(7点以上,7.2%),下位尺度:lack of affection(LA)は35人(4点以上,9.3%),下位尺度:anger and rejection(AR)は17人(4点以上,4.5%)だった。多変量調整OR(95%CI)はパートナーへの関わり高得点群に対し,ボンディング障害は中得点群:4.81(1.88-12.33),低得点群:6.89(1.40-33.93),下位尺度LAは中得点群:2.21(0.97-5.04),低得点群:6.40(1.54-26.68)であった一方,下位尺度ARと有意な関連がみられなかった(trend Pは順に0.0005,0.0053,0.6859)。結論 妊娠期の父親のパートナーへの良好でない関わりが父親のボンディング障害と子どもへの愛情の欠如に影響することが考えられる。父親のボンディング障害の予防には妊娠期におけるパートナーへの関わりが重要であることが示唆された。(著者抄録)
• Association between reproductive factors with lung cancer incidence and mortality: A pooled analysis of over 308,000 females in the Asia Cohort Consortium

  Xin Yin, Rie Kishida, Sarah Krull Abe, Md. Rashedul Islam, Md. Shafiur Rahman, Eiko Saito, Qing Lan, Batel Bletcher, Melissa Merritt, Ji-Yeob Choi, Aesun Shin, Ryoko Katagiri, Xiao-Ou Shu, Norie Sawada, Akiko Tamakoshi, Woon-Puay Koh, Ichiro Tsuji, Chisato Nagata, Sue K. Park, Sun-Seog Kweon, Yu-Tang Gao, Shoichiro Tsugane, Takashi Kimura, Jian-Min Yuan, Yukai Lu, Seiki Kanemura, Yumi Sugawara, Keiko Wada, Min-Ho Shin, Habibul Ahsan, Paolo Boffetta, Kee Seng Chia, Keitaro Matsuo, You-Lin Qiao, Nathaniel Rothman, Wei Zheng, Manami Inoue, Daehee Kang, Wei Jie Seow  CANCER RESEARCH  83-  (7)  2090  -2105  2023/04  

  Previous studies have investigated the association between reproductive factors and lung cancer risk; however, findings have been inconsistent. In order to assess this association among Asian women, a total of 308,949 female participants from 11 prospective cohorts and four Asian countries (Japan, Korea, China, and Singapore) were included. Cox proportional hazards regression models were used to estimate the hazard ratios (HR) and 95% confidence intervals (CIs). A total of 3,119 primary lung cancer cases and 2247 lung cancer deaths were identified with a mean follow-up of 16.4 years. Parous women had a lower risk of lung cancer incidence and mortality as compared with nulliparous women, with HRs of 0.82 (95% CI = 0.70-0.96) and 0.78 (95% CI = 0.65-0.94). The protective association of parity and lung cancer incidence was greater among ever-smokers (HR = 0.66, 95% CI = 0.49-0.87) than in never-smokers (HR = 0.90, 95% CI = 0.74-1.09) (P-interaction = 0.029). Compared with age at first delivery ≤20 years, older age at first delivery (21-25, ≥26 years) was associated with a lower risk of lung cancer incidence and mortality. Women who ever used hormone replacements had a higher likelihood of developing non-small cell lung cancer (HR = 1.31, 95% CI = 1.02-1.68), compared to those who never used hormone replacements. Future studies are needed to assess the underlying mechanisms, the relationships within these female reproductive factors, and the potential changes in smoking habits over time.
• 岩見沢市母子健康調査(SMILE Iwamizawa)における妊娠期から出産後の母体腸内細菌叢解析

  和泉 裕久, 両角 麻衣, 田畑 風華, 川上 智美, 武田 安弘, 宮地 一裕, 中村 公則, 綾部 時芳, 中岡 慎治, 相沢 智康, 中村 宝弘, 木村 尚史, 中村 幸志, 玉腰 暁子  腸内細菌学雑誌  37-  (2)  122  -122  2023/04
• 岩見沢市母子健康調査(SMILE Iwamizawa)における乳児の腸内細菌叢解析

  両角 麻衣, 和泉 裕久, 田畑 風華, 川上 智美, 武田 安弘, 宮地 一裕, 中村 公則, 綾部 時芳, 中岡 慎治, 相沢 智康, 中村 宝弘, 木村 尚史, 中村 幸志, 玉腰 暁子  腸内細菌学雑誌  37-  (2)  123  -123  2023/04
• 低炭水化物食スコアと糖代謝指標との関連

  八重樫 昭徳, 木村 尚史, 岡田 恵美子, 中村 幸志, 鵜川 重和, 中村 昭伸, 玉腰 暁子  日本栄養・食糧学会大会講演要旨集  77回-  328  -328  2023/03
• 新型コロナウイルス感染症罹患後の健康影響-札幌市在住小児対象調査-

  木村尚史, 春原怜史, 堀幸, 細澤麻里子, 西條政幸, 磯博康, 玉腰暁子  日本公衆衛生学会総会抄録集(CD-ROM)  82nd-  2023
• 前期高齢期における社会的活動への参加と認知症発症との関連:NISSIN project

  谷口璃華, 鵜川重和, 岡林里枝, 木村尚史, 若井建志, 津下一代, 玉腰暁子  日本公衆衛生学会総会抄録集(CD-ROM)  82nd-  461  -461  2023
• 札幌市におけるCOVID-19ワクチン接種回数と罹患後症状との関連

  大島慧士, 木村尚史, 春原怜史, 若狭はな, 西條政幸, 玉腰暁子  日本公衆衛生学会総会抄録集(CD-ROM)  82nd-  566  -566  2023
• 札幌市におけるCOVID-19に関する情報媒体の使用とワクチン接種の関連性

  春原怜史, 春原怜史, 朝倉利晃, 朝倉利晃, 木村尚史, 西條政幸, 玉腰暁子  日本公衆衛生学会総会抄録集(CD-ROM)  82nd-  564  -564  2023
• Response to antiviral therapy for chronic hepatitis C and risk of hepatocellular carcinoma occurrence in Japan

  山極洋子, 山極洋子, 田中恵太郎, 松尾恵太郎, 和田恵子, 林櫻松, 菅原由美, 溝上哲也, 澤田典絵, 瀧本秀美, 伊藤秀美, 北村哲久, 坂田律, 木村尚史, 田中詩織, 井上真奈美  日本癌学会学術総会抄録集(Web)  82nd-  1091  -1091  2023/09
• 日本人における総脂質及び脂肪酸摂取量と糖尿病発症との関連:JACC Study

  八重樫昭徳, 八重樫昭徳, 木村尚史, 若井建志, 磯博康, 玉腰暁子  日本疫学会学術総会講演集(Web)  33rd-  2023
• 顎顔面の形態や機能が小児の睡眠の質に与える影響について

  黒坂 寛, 木村 尚史, 白石 優季, 長田 奈幹, 山本 沙優里, 池原 賢代, 磯 博康, 山城 隆  日本公衆衛生学会総会抄録集  81回-  388  -388  2022/09
• COVID-19における発症から陽性確定の遅れに関連する患者要因の分析

  綿貫 大智, 朝倉 利晃, 木村 尚史, 中西 香織, 玉腰 暁子  日本公衆衛生学会総会抄録集  81回-  456  -456  2022/09
• 平成30年北海道胆振東部地震における大規模停電時の札幌市在宅人工呼吸器患者への対応の実態と課題

  方波見 謙一, 木村 尚史, 玉腰 暁子  日本在宅救急医学会誌  5-  (2)  1  -7  2022/03  

  【目的】平成30年北海道胆振東部地震に伴った停電における、札幌市在宅人工呼吸器患者への対応の実態と入院となったリスク要因を検討する。【方法】札幌市在宅医療協議会所属会員を対象として行われたアンケート調査を利用し、本研究を行った。【結果】札幌市内の在宅人工呼吸器患者数は230名であった。使用時間が常時(24時間)であれば入院に対するPR(prevalence ratio)は9.07(95%CI:5.10〜16.10、p<.0001)、人工呼吸器設定についてはTPPV(tracheostomy positive pressure ventilation)の場合、TPPVではない場合に比べ入院に対するPRは3.57(95%CI:2.29〜5.55、p<.0001)であった。年齢と使用時間による多変量解析では、使用時間のPRが9.21(95%CI:5.17〜16.39、p<.0001)であった。入院とならなかった患者は147名であり、入院回避の理由として、電源が確保できたが87名(59.2%)で、自家用車からの電源確保が35名(40.2%)であった。【結語】災害に伴った停電時には在宅人工呼吸器24時間使用は入院のリスクとなる。リスクが高い患者において日ごろから自家用車などの非常電源を確保しておくことが、災害急性期の停電対策として重要である。(著者抄録)
• 札幌市における新型コロナウイルス感染症罹患後症状の実態

  木村尚史, 朝倉利晃, 細澤麻里子, 堀幸, 中西香織, 磯博康, 玉腰暁子  日本公衆衛生学会総会抄録集(CD-ROM)  81st-  2022
• The observational study of natto (fermented soybeans) allergy among fishery workers in a rural area.

  KUROTORI Isaku, KIMURA Takashi, SASAO Wataru, ABE Masahiko, KUMAGAI Hideki, TAMAKOSHI Akiko  日本プライマリ・ケア連合学会学術大会(Web)  13th-  2022
• 地域在住高齢者における歩行と認知機能の関連 横断研究(Association of gait with cognitive function among community-dwelling older adults: a cross-sectional study)

  Hao Wen, Zhao Wenjing, Kimura Takashi, Ukawa Shigekazu, Kadoya Ken, Kondo Katsunori, Tamakoshi Akiko  Journal of Epidemiology  32-  (Suppl.1)  92  -92  2022/01
• 気道異物による死亡のリスク因子 日本多施設共同コホート研究(Risk Factors of Mortality from Foreign Bodies in the Respiratory Tract: The Japan Collaborative Cohort Study)

  Katabami Kenichi, Kimura Takashi, Hirata Takumi, Tamakoshi Akiko  Journal of Epidemiology  32-  (Suppl.1)  154  -154  2022/01
• COVID-19に対する経済的影響を加味した世代別のワクチン優先接種戦略

  春原 怜史, 朝倉 利晃, 木村 尚史, 小澤 隼, 大島 慧士, 山内 大瑚, 玉腰 暁子  Journal of Epidemiology  32-  (Suppl.1)  118  -118  2022/01
• スクリーンタイムが肥満に及ぼす影響

  若狭 はな, 木村 尚史, 平田 匠, 玉腰 暁子  日本公衆衛生学会総会抄録集  80回-  369  -369  2021/11
• 産前における夫婦関係と父親のボンディング障害との関連

  田中 嘉き, 岡田 恵美子, 平田 匠, 木村 尚史, 玉腰 暁子  日本公衆衛生学会総会抄録集  80回-  386  -386  2021/11
• 緑茶とうつとの関連 観察研究のシステマティックレビューとメタアナリシス

  八重樫 昭徳, 木村 尚史, 平田 匠, 玉腰 暁子  日本公衆衛生学会総会抄録集  80回-  473  -473  2021/11
• 札幌市におけるCOVID-19のリアルタイムデータ収集、分析、共有(Real-time data collection, analysis and sharing for COVID-19 in Sapporo City)

  Ozawa Shun, Asakura Toshiaki, Sunohara Satoshi, Oshima Satoshi, Yamauchi Daigo, Kimura Takashi, Nakanishi Kaori, Tamakoshi Akiko  日本公衆衛生学会総会抄録集  80回-  314  -314  2021/11
• 地域在住高齢者における不眠と口腔関連QOLの関係(CHEER Iwamizawa)

  渡邊 裕, 三浦 和仁, 馬場 陽久, 近藤 美弥子, 松下 貴恵, 岡田 和隆, 山崎 裕, 齋藤 博, 木村 尚史, 玉腰 暁子  睡眠口腔医学  8-  (総会特別号)  54  -54  2021/11
• 高齢者におけるたんぱく質摂取量と骨格筋量及び除脂肪量との関連 システマティックレビュー

  八重樫 昭徳, 木村 尚史, 平田 匠, 玉腰 暁子  日本サルコペニア・フレイル学会雑誌  5-  (Suppl.)  216  -216  2021/10
• Association of dietary diversity with all-cause mortality by body mass index in Japanese older adults

  Saeka Takabayashi, Takumi Hirata, Wenjing Zhao, Takashi Kimura, Shigekazu Ukawa, Kazuyo Tsushita, Kenji Wakai, Takashi Kawamura, Masahiko Ando, Akiko Tamakoshi  INTERNATIONAL JOURNAL OF EPIDEMIOLOGY  50-  2021/09
• 薬局を対象とした「指定成分等含有食品」の認知度および流通状況に関する横断研究

  藤井 仁, 湯川 慶子, 新井 一郎, 児玉 知子, 木村 尚史  Therapeutic Research  42-  (6)  423  -429  2021/06  

  目的:2020年の改正食品衛生法で定められた4つの指定成分を含む健康食品が薬局でどの程度流通しているのか、特に取り扱いが多い薬局の特徴は何か、薬局でどの程度指定成分等含有食品のことが知られているかを明らかにすることを目的とする。方法:調査会社を通じて全国の薬局名簿から完全無作為に抽出した薬局1000店舗の仕入れ担当者に調査票を郵送し、(1)健康食品を取り扱っているか、(2)指定成分等含有食品が4つ定められる予定であることを知っているか、(3)4つの指定成分等含有食品が何かを知っているか、(4)4つの指定成分等含有食品を過去に取り扱ったことがあるか、(5)4つの指定成分等含有食品を今販売しているか、(6)今後、4つの指定成分等含有食品の取り扱いを続けるか、止めるか、(7)新たに既存の健康食品が指定成分等含有食品に指定されたらどのような対応をとるか、などについて質問した。結果:183の薬局からの回答を分析対象とした。有効回答率18.3%であった。制度自体の認知度、健康被害の報告義務、4つの指定成分等含有食品の名称、過去に生じた健康被害等についての認知度は非常に低かった。また、501社以上の規模をもつ大手チェーン店とネット販売をしている業者で認知度が高かった。結論:指定成分等含有食品の認知度は非常に低かったが、指定成分等含有食品が健康被害を生じさせうる商品であり、健康被害が生じた際には報告の義務が課されることを認識したうえで販売を続けようとする担当者はおらず、適切な情報提供によって販売を自制させることができると考えられた。また、ネット販売をしている薬局では指定成分等含有食品の認知度が高く、これらの業者は実店舗では販売しないがネットを介して販売している可能性があり、注意喚起が必要であると考えられる。(著者抄録)
• 地域住民における喫煙(新型タバコを含む)と抑うつ症状との関連

  柏倉 揚子, 木村 尚史, 玉腰 暁子  Journal of Epidemiology  31-  (Suppl.1)  121  -121  2021/01
• 女性は男性よりも身体活動量が少ないか DOSANCO Health Study

  天笠 志保, 井上 茂, 鵜川 重和, 佐々木 幸子, 中村 幸志, 吉村 彩, 田中 綾, 木村 尚史, 中川 貴史, 今江 章宏, Ding Ding, 菊池 宏幸, 玉腰 暁子  Journal of Epidemiology  31-  (Suppl.1)  127  -127  2021/01
• 寒冷積雪地の地域在住高齢者における加速度計による身体活動量と転倒との関連

  小島 令嗣, 鵜川 重和, 横道 洋司, 田中 綾, 木村 尚史, 天笠 志保, 井上 茂, 近藤 克則, 玉腰 暁子  Journal of Epidemiology  31-  (Suppl.1)  134  -134  2021/01
• 北海道内の二次医療圏単位にみた大腸がん発見に関する研究

  高橋 祥, 木村 尚史, 玉腰 暁子  日本公衆衛生学会総会抄録集  79回-  240  -240  2020/10
• 覚せい剤依存症患者の特徴と治療予後の関連

  山本 泰輔, 木村 尚史, 玉腰 暁子, 松本 俊彦  日本公衆衛生学会総会抄録集  79回-  267  -267  2020/10
• 妊婦の自閉症傾向特性の特徴について 子どもの健康と環境に関する全国調査

  廣川 空美, 木村 尚史, 池原 賢代, 本庄 かおり, 植田 紀美子, 佐藤 拓代, 磯 博康  日本公衆衛生学会総会抄録集  79回-  360  -360  2020/10
• 地域在住日本人高齢者におけるたんぱく質摂取量と骨格筋量、筋肉量、握力との関連

  八重樫 昭徳, 木村 尚史, 平田 匠, 岡田 恵美子, 中村 幸志, 鵜川 重和, 玉腰 暁子  日本公衆衛生学会総会抄録集  79回-  468  -468  2020/10
• 新型コロナウイルス感染症情報の効率的な把握・提供・共有のための北海道における取り組み

  玉腰 暁子, 朝倉 利晃, 木村 尚史, 平田 匠, 人見 嘉哲, 中瀬 克己  病原微生物検出情報月報  41-  (5)  86  -87  2020/05  [Not refereed][Not invited]
  
• 情報入力用ファイルと集計用GUIアプリを用いた日常業務内における新型コロナウイルス感染症情報の把握例の紹介情報入力用ファイルと集計用GUIアプリを用いた日常業務内における新型コロナウイルス感染症情報の把握例の紹介

  木村尚史, 朝倉利晃, 玉腰暁子, 人見嘉哲, 山口亮  Infectious Agents Surveillance Report  41-  87  -88  2020/05  [Not refereed][Not invited]
  
• 日本人地域一般住民におけるアーキアと肥満との関連 The DOSANCO Health Study

  山村 凌大, 鵜川 重和, 中村 幸志, 木村 尚史, 中川 貴史, 今江 章宏, 國弘 忠生, 朴 鐘旭, Mohsen Attayeb, 川島 和, 清水 由宇, 中村 公則, 綾部 時芳, 玉腰 暁子  腸内細菌学雑誌  34-  (2)  107  -107  2020/04
• 日本人地域一般住民におけるアーキアと肥満との関連 The DOSANCO Health Study

  山村 凌大, 鵜川 重和, 中村 幸志, 木村 尚史, 中川 貴史, 今江 章宏, 國弘 忠生, 朴 鐘旭, Mohsen Attayeb, 川島 和, 清水 由宇, 中村 公則, 綾部 時芳, 玉腰 暁子  腸内細菌学雑誌  34-  (2)  107  -107  2020/04
• 消費者向け媒体における健康食品に関する注意喚起の伝達状況分析 雑誌

  見島 亜莉沙, 溝口 貴文, 新井 一郎, 三澤 仁平, 木村 尚史, 湯川 慶子, 児玉 知子, 藤井 仁  日本薬学会年会要旨集  140年会-  27P  -pm009S  2020/03
• 消費者向け媒体における健康食品に関する注意喚起の伝達状況分析 新聞・ネット販売サイト

  溝口 貴文, 見島 亜莉沙, 新井 一郎, 三澤 仁平, 木村 尚史, 湯川 慶子, 児玉 知子, 藤井 仁  日本薬学会年会要旨集  140年会-  27P  -pm010S  2020/03
• Associations of gut microbiota, dietary intake, and serum SCFAs with fecal SCFAs

  YAMAMURA Ryodai, NAKAMURA Koshi, NAKAMURA Koshi, KITADA Naoya, AIZAWA Tomoyasu, SHIMIZU Yu, NAKAMURA Kiminori, AYABE Tokiyoshi, KIMURA Takashi, TAMAKOSHI Akiko  日本細菌学雑誌(Web)  75-  (1)  2020
• 腸内細菌叢、食事摂取量、血清SCFAsと大便中SCFAsの関連性(Associations of gut microbiota, dietary intake, and serum SCFAs with fecal SCFAs)

  山村 凌大, 中村 幸志, 北田 直也, 相沢 智康, 清水 由宇, 中村 公則, 綾部 時芳, 木村 尚史, 玉腰 暁子  日本細菌学雑誌  75-  (1)  70  -70  2020/01
• 居住形態と産後うつ傾向の関連 子どもの健康と環境に関する全国調査(エコチル調査)

  本庄 かおり, 木村 尚史, 池原 賢代, 馬場 幸子, 北野 尚美, 佐藤 拓代, 磯 博康  日本公衆衛生学会総会抄録集  78回-  228  -228  2019/10
• 過去に健康被害を生じさせた健康食品に関する情報発信の課題と対策

  藤井 仁, 木村 尚史, 三澤 仁平  日本公衆衛生学会総会抄録集  78回-  567  -567  2019/10
• エコチル調査大阪ユニットセンターにおける質問票回収に影響する地理的要因の検討

  谷川果菜美, 木村尚史, 池原賢代, 池原賢代, 董加毅, 崔美善, 青地ゆり, 植田紀美子, 磯博康  日本疫学会学術総会講演集(Web)  29th-  2019
• 妊婦の喫煙及び飲酒 エコチル調査大阪ユニットセンターでの状況

  池原 賢代, 木村 尚史, 柿ヶ野 藍子, 佐藤 拓代, 磯 博康  日本公衆衛生学会総会抄録集  77回-  372  -372  2018/10
• エコチル調査大阪ユニットセンターにおける質問票回収に影響する要因の検討

  崔 美善, 木村 尚史, 董 加毅, 池原 賢代, 植田 紀美子, 磯 博康  日本公衆衛生学会総会抄録集  77回-  380  -380  2018/10
• エコチル調査大阪ユニットセンターにおける質問票回収に関する検討 2

  青地ゆり, 木村尚史, 谷川果菜美, 池原賢代, 池原賢代, 佐藤拓代, 磯博康  日本疫学会学術総会講演集(Web)  28th-  2018
• 女性の生殖歴と循環器疾患死亡リスクとの関連 The JACC study

  谷川 果菜美, 磯 博康, 木村 尚史, 池原 賢代, 玉腰 暁子  日本公衆衛生学会総会抄録集  76回-  291  -291  2017/10
• 大阪ユニットセンターの活動

  磯 博康, 佐藤 拓代, 池原 賢代, 山崎 不二子, 木村 尚史  チャイルドヘルス  19-  (7)  526  -527  2016  [Not refereed][Not invited]
  

Books etc

• 社会疫学＜下＞

  木村 尚史 (Joint translation第9章)
  大修館書店 2017/09

Presentations

• 新型コロナウイルス感染症に関する行政データと疫学研究データの結合：札幌市の事例を通じて  [Invited]

  木村尚史

  日本計算機統計学会第37回シンポジウム  2023/11
• 新型コロナウイルス感染症罹患後の健康影響 -札幌市在住小児対象調査-  [Not invited]

  木村尚史, 春原怜史, 堀幸, 細澤麻里子, 西條政幸, 磯博康, 玉腰暁子

  第82回日本公衆衛生学会学術総会  2023/11
• The linkage between administrative data and epidemiological research data: The Case of Sapporo City  [Invited]

  Takashi Kimura

  The 33rd Annual Scientific Meeting of the Japan Epidemiological Association  2023/02
• 札幌市における新型コロナウイルス感染症患者の特徴  [Not invited]

  木村尚史, 朝倉利晃, 黒鳥偉作, 春原怜史, 中西香織, 西條政幸, 玉腰暁子

  第33回日本疫学会総会  2023/02
• 札幌市における新型コロナウイルス感染症罹患後症状の実態  [Not invited]

  木村尚史, 朝倉利晃, 細澤麻里子, 堀幸, 中西香織, 磯博康, 玉腰暁子

  第81回日本公衆衛生学会  2022/10
• Risk of drowning: the Japan Collaborative Cohort (JACC) Study  [Not invited]

  Takashi Kimura, Satoyo Ikehara, Hiroyasu Iso, Akiko Tamakoshi, for the JACC study

  World Congress of Epidemiology 2021  2021/09
• JACC studyの概要  [Not invited]

  木村尚史

  コホート・生体試料支援プラットフォーム 令和２年度若手支援研究成果発表会  2021/02
• Association between lean, obesity and gut microbiota in a general Japanese population: The DOSANCO Health Study  [Not invited]

  木村尚史, 山村凌大, 檜森亮吾, 鵜川重和, 中村幸志, 中川貴史, 今江章宏, 國弘忠生, 朴鐘旭, Attayeb Mohsen, 川島和, 清水由宇, 中村公則, 綾部時芳, 玉腰暁子

  第24回腸内細菌学会学術集会  2020/06
• エコチル調査大阪ユニットセンターにおける質問票回収に影響する要因の検討1  [Not invited]

  木村 尚史, 谷川 果菜美, 青地 ゆり, 池原 賢代, 佐藤 拓代, 磯 博康

  第28回日本疫学会総会  2018/02

Association Memberships

• 日本計算機統計学会   JAPAN EPIDEMIOLOGICAL ASSOCIATION   JAPANESE SOCIETY OF PUBLIC HEALTH   

Research Projects

• 新型コロナウイルス感染症の長期的健康影響の解明：前向きコホート研究

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2023/04 -2026/03 

  Author : 木村 尚史
• 混合研究法による積雪寒冷地において冬季身体活動量低下を防止するプログラムの検討

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2020/04 -2024/03 

  Author : 玉腰 暁子, 佐々木 幸子, 木村 尚史

   

  当初検討していた地域での調査研究の実施は困難と判断し、北海道内のK高校に場を移した。高校2年生の「探究の時間」を用いて、高校生自身に身体活動を冬季に低下させないための案を検討させ、取り組みを行った。具体的には、１．今の自分の体を知る (ア)身長、体重、握力、血圧、歩行測定、Inbodyによる計測 (イ)継続的にGarmin活動量計をつけて身体活動量を計測し、自分のデータならびにグループのデータの分析 ２．冬に活動量を落とさない方法を提案・実践する (ア)身体活動の現状と健康との関連を生徒たちが様々な方法を用いて調査し発表、共有 (イ)調べたことをベースに高校生が冬季に身体活動量を落とさない方法を提案 (ウ)その効果を明らかにするための研究を立案、友人らを対象に実施、とし、2022年７月より約７か月間で行った。本授業を受講した23名の生徒は、身体活動と自分たちの健康との関連について先行研究を調べ、その重要性を認識した。また、Garminデータのダウンロードを自身で行うことができるようになり、エクセルを用いたデータ分析能力も向上した。その上で、自分たちで研究計画を立案し、46名の生徒を対象とした介入研究を行った。生徒達が冬季に活動量を減らさない策として提案したラジオ体操を実施した群は、実施しなかった群と比べて冬休み期間の活動量の減少が小さく、健康意識も増加していた。生徒たちはその結果を自分たちの言葉でまとめ、学術祭で他の生徒や教員、外部参加者に伝えることができた。
• Association of COVID-19 with worsening of pre-existing conditions, and sequelae.

  厚生労働省：厚生労働科学研究費補助金特別研究事業

  Date (from‐to) : 2021/07 -2022/03 

  Author : 木村尚史, 玉腰暁子, 西條政幸
• 北海道における新型コロナウイルス感染症の重症化・死亡リスクに関する分析

  Hokkaido University：FY2021 Support System for the Collaborative Research of Next-Generation Researchers

  Date (from‐to) : 2021/06 -2022/03 

  Author : 木村尚史
• 科学的根拠に基づくがんリスク評価とがん予防ガイドライン提言に関する研究

  国立研究開発法人 国立がん研究センター：年度国立がん研究センター運営費交付金研究開発費

  Date (from‐to) : 2021/04
• A cohort study of maternal urinary biomarkers during pregnancy in relation to changes in blood pressure and their children's food preference

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2015/04 -2018/03 

  Author : Ikehara Satoyo, UMESAWA Mitsumasa, KIMURA Takashi, TANIGAWA Kanami, AOCHI Yuri, CUI Meishan

   

  As for spot urine in the 1st trimester, Mg/Cre and UN/Cre were inversely associated with blood pressure (BP) levels during pregnancy and one month after childbirth, and Ca/Cre was inversely associated with BP levels one month after childbirth. Na/K was positively associated with BP levels during pregnancy and one month after childbirth. As for spot urine in the 2nd-to-3rd trimester, Mg/Cre was inversely associated with BP levels during pregnancy and one month after childbirth. Ca/Cre was positively associated with systolic BP (SBP) levels in the 2nd and 3rd trimesters. Na/K was positively associated with SBP levels in the 3rd trimester. UN/Cre was inversely associated with BP levels in the 3rd trimester and one month after childbirth. For taste preference in 4.5-year children, maternal Na/K in the 1st trimester was inversely associated with sweet food preference, while Na/Cre in the 2nd-to-3rd trimester was positively associated with salty food preference.
• Epidemiological study of urine biomarkers that contribute to the prevention of chronic disease in childhood

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2012/04 -2015/03 

  Author : SHIMIZU Yuji, ISO Hiroyasu, IKEHARA Satoyo, KIMURA Takashi

   

  We examined the association of urine biomarkers with hypertension (HT) and diabetes (DM) among 5990 pregnant women who participated in the Osaka Regional Canter, the Japan Environment and Children's Study. We measured sodium (Na), potassium (K), urea nitrogen (UN) as biomarkers related to hypertension and C-peptide (CPR) as a biomarker related to diabetes. Na/K at the first trimester was associated with increased systolic blood pressure (SBP) and HT at the first, second and third trimesters and increased diastolic blood pressure (DBP) at the second and third trimesters, while UN/Cr at the first trimester was associated with decreased DBP at the first, second and third trimesters and decreased SBP and HT at the second and third trimesters. UN/Cr at the second/third trimester was associated with increased HT at the third trimester. CPR/Cr at the first trimester was not associated with HbA1c and DM at the first trimester.
• 健康食品等の安全確保に必要な技術的課題への対応と効果的な情報発信のための研究

  厚生労働科学研究費

  Author : 藤井仁, 湯川慶子, 新井一郎, 木村尚史, 三澤仁平