Researcher basic information

• Doctor of Science, Hokkaido University, Mar. 1994
• Doctor of Engineering, Tokyo Institute of Technology, Mar. 1994

• https://researchmap.jp/jian-ping-gong?lang=en

• https://jglobal.jst.go.jp/detail?JGLOBAL_ID=200901093797381400
• http://altair.sci.hokudai.ac.jp/g2/

• B-7019-2009

• 200901093797381400

• Sacrificial bond
• Regenerative medicine
• Biomaterials
• Cell Scaffold
• Artificial cartilage
• Lubrication
• Friction
• Toughness
• Mechanical strength
• Soft and wet
• Polymer gel

• Nanotechnology/Materials, Fundamental physical chemistry
• Life Science, Biomaterials
• Life Science, Biomedical engineering
• Natural Science, Biophysics, chemical physics and soft matter physics
• Nanotechnology/Materials, Polymer materials
• Nanotechnology/Materials, Thin film/surface and interfacial physical properties
• Life Science, Biophysics

• Bachelor's degree program, School of Science
• Master's degree program, Graduate School of Life Science
• Doctoral (PhD) degree program, Graduate School of Life Science

Research activity information

• Jun. 2024, The Royal Society of Chemistry, 2024 Materials Chemistry Horizon Prize
  For demonstrating the potential and impact of embedded mechanochemical reactivity on the mechanical limits of cross-linked polymer networks
  NSF Center for Molecularly;Optimized Networks
• Mar. 2023, American Physical Society, 2023 Polymer Physics Prize
  For outstanding contributions to the understanding of mechanical and fracture properties of hydrogels based on novel network architectures and for discovering the concept of double network gels based on internal overstressed sacrificial bonds
  Jian Ping Gong
• Mar. 2022, Chemical Society of Japan, The 74th Chemical Society of Japan (CSJ) Award
  Creation of Diverse Soft Materials with High Toughness by Sacrificial Bond Principle
  Jian Ping Gong
• May 2021, The Society of Rubber Science and Technology, Japan, Award of the Society of Rubber Science and Technology, Japan (2021)
  Development of a polymer complex that achieves both low fuel consumption and high strength toward the realization of resource-saving tires
  Katsuhiko Tsunoda;Kohzo Ito;Hideaki Yokoyama;Jian Ping Gong;Kenji Urayama, 24510616
• Apr. 2019, Ministry of Education, Culture, Sports, Science and Technology, 2019 The Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology: Prizes for Science and Technology
  受賞した研究テーマ「強靭ゲルの創成とその強靭化原理の解明に関する研究
  Jian Ping Gong, Others
• Mar. 2018, Hokkaido University President's Award for Excellence in Research and Education for AY2017
  Jian Ping Gong
• Jul. 2014, Royal DSM, The DSM Materials Sciences Award 2014
  Jian Ping Gong
• Mar. 2014, 平成25年度北海道大学研究総長賞
  グン 剣萍
• 2011, 日本化学会 第28回学術賞
  Japan
• 2011, The Chemical Society of Japan Award for Creative Work for 2011
• 2006, 高分子学会賞（科学）
  Japan
• 2006, The Award of the Society of Polymer Science, Japan
• 2001, 2001年Wiley高分子科学賞（物理学分野）
  Japan
• 2001, 2001 Wiley Polymer Science Award (Physics)

• Astrocyte-Glioblastoma Stem Cell Interactions via Extracellular Vesicles Contribute to Distinct Vascular Structures.
  Yusuke Shirai; Masumi Tsuda; Lei Wang; Yoshitaka Oda; Hirokazu Sugizno; Zen-Ichi Tanei; Jian Ping Gong; Shinya Tanaka
  Pathology international, 76, 2, e70099, 19 Feb. 2026, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Glioblastoma (GBM) is a highly malignant astrocytic tumor characterized by marked heterogeneity and therapeutic resistance. Cancer stem-like cells (CSCs) drive recurrence within specialized microenvironments, such as perivascular niches. Glioblastoma stem cells have been considered to interact with surrounding stromal cells, including astrocytes. To investigate these cell communications, we used a co-culture system of glioblastoma KMG4 cells and immortalized human astrocytes (NHA-TS) on hydrogels. Co-culture on hydrogel induced stemness- and epithelial-mesenchymal transition-related genes. Glioblastoma- and astrocyte-derived extracellular vesicles (EVs) were incorporated into reciprocal cells. NHA-TS-derived EVs regulated stemness of KMG4 cells, whereas KMG4-derived EVs increased expression of vascular development-related genes, such as THBS1 and ANGPT1 in astrocytes. Proteomic analysis identified COL1A1 and THBS1 in KMG4 and NHA-TS co-culture EVs. Spatial transcriptomic analysis of human GBM tissue demonstrated THBS1 and COL1A1 expression in perivascular regions. Culturing KMG4 cells on PNaSS gels upregulated pericyte-associated genes such as ACTA2, PDGFRB, HIGD1B. Within the perivascular microenvironment, EV-mediated interactions between glioblastoma cells and astrocytes support the induction of stemness and the differentiation of GBM cells toward a pericyte-like phenotype, promoting perivascular niche formation and microvascular proliferation. The hydrogel-based co-culture model thus provides a simple and effective platform for dissecting tumor-stroma communication in the glioblastoma microenvironment.
• Soft and tough bio-composites via integration of agricultural products and polymer gels
  Honoka Matsuura; Kagari Maruyama; Shou Ohmura; Jian Ping Gong; Tasuku Nakajima
  Science and Technology of Advanced Materials, 27, 1, Informa UK Limited, 21 Jan. 2026, [Peer-reviewed], [International Magazine]
  English, Scientific journal, 36977687;42408869
• Reimagining Polymer Networks from Molecule to Material
  Noy B. Nechmad; Luis M. Campos; Stephen L. Craig; Chuting Deng; Jackson Diodati; Sunay D. Ekim; Emmanuel Garcia Villatoro; Jian Ping Gong; Abraham Herzog-Arbeitman; Xiao Huang; Jeremiah A. Johnson; Julia A. Kalow; Ryann E. Kemmerling; Ilia Kevlishvili; Ana Paula Kitos Vasconcelos; Rebekka S. Klausen; Heather J. Kulik; Jorge Leganés Bayón; Yingzi Ma; Elvis Mcfee; Juana Mendenhall; Jeffrey S. Moore; Alshakim Nelson; Bradley D. Olsen; Michael Rubinstein; Corinna S. Schindler; Nancy R. Sottos; Nicole F. Steinmetz; Shixuan Wei; Fangbai Xie
  Macromolecules, 58, 24, 12909, 12930, American Chemical Society (ACS), 12 Dec. 2025, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal
• Aromatic Residues Drive Polyelectrolyte Coacervates into Hydrogels for Underwater and Underoil Adhesion
  Zhili Zhang; Yonglin He; Ting Wang; Xiaoyuan Wang; Hongguang Liao; Misaki Sawada; Xiang Li; Hailong Fan; Jian Ping Gong
  Macromolecules, 58, 19, 10810, 10817, American Chemical Society (ACS), 30 Sep. 2025, [Peer-reviewed], [Last author, Corresponding author], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal, 42408869;36977687
• Nonlinearity tunes crack dynamics in soft materials
  Fucheng Tian; Jian Ping Gong
  Journal of the Mechanics and Physics of Solids, 202, 106191, 106191, Elsevier BV, Sep. 2025, [Peer-reviewed], [Corresponding author], [International Magazine]
  English, Scientific journal, 42408869;36977687
• Computational Exploration of Polymer Mechanochemistry: Quantitation of Activation Force and Systematic Discovery of Reaction Sites by the Extended Artificial Force-Induced Reaction Method
  Julong Jiang; Koji Kubota; Yu Harabuchi; Mingoo Jin; Zhi Jian Wang; Tasuku Nakajima; Hajime Ito; Jian Ping Gong; Satoshi Maeda
  Journal of the American Chemical Society, 147, 36, 32502, 32521, American Chemical Society (ACS), 29 Aug. 2025, [Peer-reviewed], [International Magazine]
  English, Scientific journal, 36977687;42408869
• Tuning the Ultimate Strain of Single and Double Network Gels Through Reactive Strand Extension
  Xujun Zheng; Chun-Yu Chiou; Sunay Dilara Ekim; Tatiana B. Kouznetsova; Jafer Vakil; Yixin Hu; Liel Sapir; Danyang Chen; Zi Wang; Michael Rubinstein; Jian Ping Gong; Nancy R. Sottos; Stephen L. Craig
  ACS Central Science, 11, 10, 1882, 1891, American Chemical Society (ACS), 15 Aug. 2025, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal
• Data-driven de novo design of super-adhesive hydrogels
  Hongguang Liao; Sheng Hu; Hu Yang; Lei Wang; Shinya Tanaka; Ichigaku Takigawa; Wei Li; Hailong Fan; Jian Ping Gong
  Nature, 644, 8075, 89, 95, Springer Science and Business Media LLC, 06 Aug. 2025, [Peer-reviewed], [Last author, Corresponding author], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal, 42408869;36977687
• Fundamental toughening landscape in soft–hard composites: Insights from a minimal framework
  Fucheng Tian; Katsuhiko Sato; Yong Zheng; Feixue Lu; Jian Ping Gong
  Proceedings of the National Academy of Sciences, 122, 27, Proceedings of the National Academy of Sciences, 03 Jul. 2025, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, Soft–hard composite strategy is a highly general yet powerful approach to overcome the inherent trade-off between strength and toughness in material design. However, the underlying toughening mechanisms, veiled by nonlinearities and complex network interactions, remains unclear. Here, we employ a three-dimensional soft–hard composite (SH- com ) framework by arranging randomly distributed linear-elastic soft and hard elements to explore the toughening mechanisms of soft–hard composites, while shielding the influence of complex nonlinearities and network architectures. Key features observed in soft–hard composites, including mechanical hysteresis, sacrificial bond-driven toughening, and brittle-to-ductile (BTD) transitions, are successfully reproduced, suggesting that the simplest model captures the essence of toughening in soft–hard composites. Visualization of internal fracture reveals distinct fracture patterns associated with the BTD transition, while numerical and theoretical analyses elucidate its mechanical origins. Furthermore, we identify an optimal toughening composition governed by a unified scaling relation linked to the fracture toughness ratio between soft and hard components. A fundamental toughening phase diagram is also established in terms of strength and toughness. This work sheds light on the underlying toughening landscape of soft–hard composite systems., 36977687;42864761
• “Node” facilitated thermostable mechanophores for rapid self-strengthening in double network materials
  Julong Jiang; Zhi Jian Wang; Ruben Staub; Yu Harabuchi; Alexandre Varnek; Jian Ping Gong; Satoshi Maeda
  Chemical Science, Royal Society of Chemistry (RSC), Jul. 2025, [Peer-reviewed], [Corresponding author], [International Magazine]
  English, Scientific journal, A conformational motif called “node” was identified, and molecules with it were studied using EX-AFIR and NNP methods. The results guided the experimental design of thermostable, self-strengthening materials., 42408869;36977687
• Yielding of Double-Network Hydrogels with Systematically Controlled Tetra-PEG First Networks
  Takahiro Matsuda; Naohiro Kashimura; Takamasa Sakai; Tasuku Nakajima; Takuto Matsushita; Jian Ping Gong
  Macromolecules, 58, 12, 6017, 6032, American Chemical Society (ACS), 09 Jun. 2025, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, 11782740;36977687;42408869
• Osmosis‐Induced Mechanical Disintegration of Polymer Network Gels
  Shou Ohmura; Kosei Oikawa; Takuya Nishimura; Ryuji Kiyama; Jian Ping Gong; Tasuku Nakajima
  Small, 2503209, Wiley, 19 May 2025, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Abstract
  
  A polymer network soaked in its good solvent absorbs the solvent molecules to swell up. The structurally possible swelling range of a polymer network is from its dried state to the structural swelling limit where its network strands reach their stretching limit. However, swelling of a polymer network to near its structural limit has not been realized due to the thermodynamic limitation. Here, this research succeeds in excessive swelling of polymer networks to or even beyond their structural swelling limit. For the excess swelling, dense linear polymers are repeatedly introduced inside a polymer network of interest. The linear polymers, trapped inside the polymer network, generate extremely high osmotic pressure and make the polymer network swell excessively. The resulting polymer networks, overswollen beyond their structural limit, disintegrate into microgels due to catastrophic scission of the polymer network strands, analogous to osmotic hemolysis of red blood cells in a hypotonic solution. This research is expected to contribute to osmosis‐induced mechanodegradation of polymer network materials and well‐controlled, swelling‐based mechanochemistry., 42408869;36977687
• Effect of the Second Network on First Network Rupture and the Origin of Energy Dissipation in Double Network Hydrogels
  Zhi Jian Wang; Gumi Wei; Tasuku Nakajima; Jian Ping Gong
  Macromolecules, 58, 9, 4835, 4846, American Chemical Society (ACS), 01 May 2025, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, 42408869;36977687
• Hydrogels with prestressed tensegrity structures
  Bin Xue; Xu Han; Haoqi Zhu; Qingtai Li; Yu Zhang; Ming Bai; Ying Li; Yiran Li; Meng Qin; Tasuku Nakajima; Wei Wang; Jian Ping Gong; Yi Cao
  Nature Communications, 16, 1, Springer Science and Business Media LLC, 16 Apr. 2025, [Peer-reviewed], [Corresponding author], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal, 36977687
• Mechanochemistry-Induced Universal Hydrogel Surface Modification for Orientation and Enhanced Differentiation of Skeletal Muscle Myoblasts
  Yuheng Nie; Qifeng Mu; Yanpeng Sun; Zannatul Ferdous; Lei Wang; Cewen Chen; Tasuku Nakajima; Jian Ping Gong; Shinya Tanaka; Masumi Tsuda
  ACS Applied Bio Materials, 8, 4, 3144, 3155, American Chemical Society (ACS), 19 Mar. 2025, [Peer-reviewed], [International Magazine]
  English, Scientific journal, 42408869;36977687
• Hydrogel PCDME creates pancreatic cancer stem cells in OXPHOS metabolic state with TXNIP elevation
  Yuma Aoki; Lei Wang; Masumi Tsuda; Yusuke Saito; Takenori Kubota; Yoshitaka Oda; Satoshi Hirano; Jian Ping Gong; Shinya Tanaka
  Biochemical and Biophysical Research Communications, 751, 151416, 151416, Elsevier BV, Mar. 2025, [Peer-reviewed], [International Magazine]
  English, Scientific journal, 36977687
• Rapid self-strengthening in double-network hydrogels triggered by bond scission
  Zhi Jian Wang; Wei Li; Xueyu Li; Tasuku Nakajima; Michael Rubinstein; Jian Ping Gong
  Nature Materials, 24, 607, 614, 26 Feb. 2025, [Peer-reviewed], [Last author, Corresponding author], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal, 42408869;36977687
• SLC13A5 plays an essential role in the energy shift to oxidative phosphorylation in cisplatin-resistant mesothelioma stem cells.
  Marie Kato-Shinomiya; Hirokazu Sugino; Lei Wang; Yusuke Saito; Jintao He; Zen-Ichi Tanei; Yoshitaka Oda; Satoshi Tanikawa; Mishie Tanino; Jian Ping Gong; Masumi Tsuda; Shinya Tanaka
  Pathology international, 75, 3, 151, 165, 06 Feb. 2025, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Mesothelioma is a highly aggressive tumor affecting an increasing number of patients worldwide. Owing to the poor clinical outcomes associated with current therapies, the development of novel therapies that target cancer stem cells (CSCs) is desirable. Here, we examined the applicability of our previously established hydrogel-based rapid CSC generation method to human mesothelioma cell lines and further analyzed the characteristics of the induced mesothelioma stem cell (MesoSC) -like cells. Human mesothelioma cell lines cultured on hydrogels presented increased expression of pan-stem cell markers and acquired spheroid formation and early tumorigenicity, suggesting that MesoSC-like cells are highly malignant. Microarray analysis demonstrated that the expression of SLC13A5, a citrate transporter involved in TCA cycle, was significantly induced in the resulting MesoSC-like cells. The overexpression of SLC13A5 resulted in a metabolic shift toward oxidative phosphorylation, increased phosphorylation of ERK and YAP, and increased SOX2 expression, leading to increased cisplatin resistance. scRNA-seq database analysis revealed that clinical mesothelioma samples contained a small number of SLC13A5-expressing cells. Our findings suggest that the hydrogel-based CSC generation method is also effective for human mesothelioma cells and that SLC13A5 may contribute to MesoSC survival. The new properties of MesoSCs revealed in this study may provide clues for establishing future treatments.
• Establishment of a novel method for differentiating into dopaminergic neurons using charged hydrogels.
  Bin Fan; Satoshi Tanikawa; Lei Wang; Takayuki Nonoyama; Yashitaka Oda; Zen-Ichi Tanei; Jian Ping Gong; Masumi Tsuda; Shinya Tanaka
  Biochemical and biophysical research communications, 747, 151280, 151280, 02 Feb. 2025, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Parkinson's disease (PD) is a neurodegenerative disease primarily affecting the central nervous system and impacting both the motor system and non-motor systems. Although administration of L-DOPA is effective, it is not a fundamental treatment and has side effects such as diurnal fluctuation and dyskinesia, highlighting the need for new treatment methods. There is a growing interest in dopaminergic neuron transplantation as a potential treatment. Dopaminergic neurons derived from pluripotent stem (iPS) cells provide a valuable source for transplantation therapies. Developing an efficient method to differentiate iPS cells into dopaminergic cells is essential for cell transplantation therapy. While Cell differentiation is typically controlled by the addition of specific reagents, the physical characteristics of culture substrate, especially in the charge and stiffness, are also crucial factors in regulating differentiation. In this research, we show that two newly developed electrically charged polymeric hydrogels composed of cationic (C) and anionic (A) monomers inratio of 1-9 and 2 to 8 can significantly promote Dopaminergic neuron differentiation. Our findings emphasize the importance of culture substrates in effective dopaminergic cell differentiation.
• Double-network hydrogels with a gradient hydrophobic coating that prevents water evaporation and allows strong adhesion to a solid substrate
  Shota Sakurai; Takayuki Kurokawa; Hidemitsu Furukawa; Jian Ping Gong; Tasuku Nakajima
  Polymer Journal, 57, 441, 447, Springer Science and Business Media LLC, 08 Jan. 2025, [Peer-reviewed], [International Magazine]
  English, Scientific journal, 42408869;36977687
• Tumor-mimetic hydrogel stiffness regulates cancer stemness properties in H-Ras-transformed cancer model cells
  Yanpeng Sun; Yuheng Nie; Lei Wang; Jian Ping Gong; Shinya Tanaka; Masumi Tsuda
  Biochemical and Biophysical Research Communications, 743, 151163, 151163, Elsevier BV, Jan. 2025, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Soft hydrogel-embedded ceramic skeleton mimicking bone structure via sacrificial bond concept
  Sukamto; Miléna Lama; Jian Ping Gong; Takayuki Nonoyama
  Soft Matter, 21, 2, 291, 303, Royal Society of Chemistry (RSC), 2025, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Tough soft/hard composites were created, inspired by bony multiple sacrificial structures through ionic bonding, fracture of the ceramic skeleton, and interactions between the new surface of fracture skeleton and hydrogel., 42408869;36977687
• Viscous solvent effect on fracture of predamaged double-network gels examined by pre-notch and post-notch crack tests
  Yong Zheng; Jian Ping Gong
  Journal of the Mechanics and Physics of Solids, 194, 105926, 105926, Elsevier BV, Jan. 2025, [Peer-reviewed], [Last author], [International Magazine]
  English, Scientific journal, 42408869;36977687
• Mechanochemistry for On-Demand Polymer Network Materials
  Zhi Jian Wang; Jian Ping Gong
  Macromolecules, 58, 1, 4, 17, American Chemical Society (ACS), 01 Jan. 2025, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, 42408869;36977687
• Analysis of synthetic polymer hydrogel-based generation of leukemia stem cells.
  Saori Sawai; Yoshitaka Oda; Yusuke Saito; Takeru Kuwabara; Lei Wang; Zen-Ichi Tanei; Shinsuke Hirabayashi; Masumi Tsuda; Jian Ping Gong; Atsushi Manabe; Shinya Tanaka
  Biochemical and biophysical research communications, 744, 151149, 151149, Jan. 2025, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Leukemia stem cells (LSCs), capable of simultaneous self-renewal and differentiation, are resistant to chemotherapy and the cause of relapse in refractory cases of leukemia. As a method to rapidly generate LSCs has not been established, research on LSCs as therapeutic targets has been hampered. Here, we demonstrate that K562 leukemia cells acquired LSC properties with increase in stemness markers such as CD34, Oct3/4, and Nanog and metabolic alterations towards OXPHOS by culturing cells on synthetic polymer hydrogels. In this hydrogel-generated LSCs, single-cell RNA sequencing identified the increase in expression levels of AKR1B1 and TSPYL5, which play an essential role for stemness generation. Decrease in expression of CD34, Oct3/4, and Nanog were observed in K562 cells with knockdown of AKR1B1 and TSPYL5. These results indicate that cell culturing on synthetic polymer hydrogels can be a useful system to generate LSCs and AKR1B1 and TSPYL5 may become therapeutic targets for LSCs.
• Tensile Behaviors of Double Network Hydrogels with Varied First Network Topological and Chemical Structures
  Feixue Lu; Tasuku Nakajima; Yong Zheng; Hailong Fan; Jian Ping Gong
  Macromolecules, 57, 24, 11520, 11533, American Chemical Society (ACS), 07 Dec. 2024, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, 42408869;36977687
• Fatigue Behaviors of Anisotropic Hydrogels with a Macroscopic Lamellar Bilayer Structure and Swelling Effects
  Most Laboni Begum; Milena Lama; Wenqi Yang; Xiang Li; Md. Anamul Haque; Xueyu Li; Jian Ping Gong
  Macromolecules, 57, 23, 10948, 10963, American Chemical Society (ACS), 26 Nov. 2024, [Peer-reviewed], [Last author, Corresponding author], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal, 42408869;36977687
• Gigantic multilayered vesicle-like hydrogel-bilayer composites
  Naoto Horihata; Jian Ping Gong; Tasuku Nakajima
  Chemistry Letters, 53, 11, Oxford University Press (OUP), 01 Nov. 2024, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Abstract
  
  Preparation of large vesicles with high stability is generally difficult. Here, we report the millimeter-scale multilayered vesicle-like hydrogel-bilayer composites with long-term stability through stabilization of the vesicular structure by polymerization of the lipid molecules and gelation of the inner solution. The well-oriented multilayered structure was examined by various methods. Reflecting the multilayered structure, the resulting vesicle-like composites exhibited extremely slow drug release behavior., 42408869;36977687
• Phase separation-induced glass transition under critical miscible conditions
  Mayu Watanabe; Dong Shi; Ryuji Kiyama; Kagari Maruyama; Yuichiro Nishizawa; Takayuki Uchihashi; Jian Ping Gong; Takayuki Nonoyama
  Materials Advances, 2024, 5, 7140, 7146, Royal Society of Chemistry (RSC), Sep. 2024, [Peer-reviewed], [International Magazine]
  English, Scientific journal, A polymer material shows phase separation-induced glass transition under critical miscible conditions, where the miscible/immiscible state is altered by temperature variations predicted by temperature-corrected Hansen solubility parameters., 42408869;36977687
• A multiscale model for the multiaxial anisotropic damage of double-network gels
  Lionel Ogouari; Qiang Guo; Fahmi Zaïri; Thanh-Tam Mai; Jian Ping Gong; Kenji Urayama
  Mechanics of Materials, 196, 105058, 105058, Elsevier BV, Sep. 2024, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal
• Unique stick–slip crack dynamics of double-network hydrogels under pure-shear loading
  Yong Zheng; Yiru Wang; Fucheng Tian; Tasuku Nakajima; Chung-Yuen Hui; Jian Ping Gong
  Proceedings of the National Academy of Sciences, 121, 30, Proceedings of the National Academy of Sciences, 17 Jul. 2024, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, In this work, we have found that a prenotched double-network (DN) hydrogel, when subjected to tensile loading in a pure-shear geometry, exhibits intriguing stick–slip crack dynamics. These dynamics synchronize with the oscillation of the damage (yielding) zone at the crack tip. Through manipulation of the loading rate and the predamage level of the brittle network in DN gels, we have clarified that this phenomenon stems from the significant amount of energy dissipation required to form the damage zone at the crack tip, as well as a kinetic contrast between the rapid crack extension through the yielding zone (slip process) and the slow formation of a new yielding zone controlled by the external loading rate (stick process)., 42408869;36977687
• Real-Space Visualization of Charged Polymer Network of Hydrogel by Double Network Strategy and Mineral Staining
  Shinji Noguchi; Ryuji Kiyama; Masahiro Yoshida; Maradhana Agung Marsudi; Naohiro Kashimura; Kiyoharu Tadanaga; Jian Ping Gong; Takayuki Nonoyama
  Nano Letters, 24, 29, 9088, 9095, American Chemical Society (ACS), 09 Jul. 2024, [Peer-reviewed], [International Magazine]
  English, Scientific journal, 42408869;36977687
• Hydrogel morphogenesis induced by force-controlled growth
  Zhi Jian Wang; Ji Lin; Tasuku Nakajima; Jian Ping Gong
  Proceedings of the National Academy of Sciences, 121, 27, Proceedings of the National Academy of Sciences, 26 Jun. 2024, [Peer-reviewed], [Last author, Corresponding author], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal, Morphogenesis is one of the most marvelous natural phenomena. The morphological characteristics of biological organs develop through growth, which is often triggered by mechanical force. In this study, we propose a bioinspired strategy for hydrogel morphogenesis through force-controlled chemical reaction and growth under isothermal conditions. We adopted a double network (DN) hydrogel with sacrificial bonds. Applying mechanical force to the gel caused deformation and sacrificial bond rupture. By supplying monomers to the gel, the radicals generated by the bond rupture triggered the formation of a new network inside the deformed gel. This new network conferred plasticity to the elastic gel, allowing it to maintain its deformed shape, along with increased volume and strength. We demonstrated that sheet-shaped DN hydrogels rapidly adopted various three-dimensional shapes at ambient temperature when subjected to forces such as drawing and blowing. This mechanism enables morphogenesis of elastic hydrogels and will promote the application of these materials in biomedical fields and soft machines., 42408869;36977687
• Pre-yielding and necking process of double network hydrogels revealed by sample geometry effects
  Masahiro Yoshida; Ryuji Kiyama; Ye Zhang; Daniel R. King; Takayuki Kurokawa; Jian Ping Gong
  Extreme Mechanics Letters, 69, 102163, 102163, Elsevier BV, Jun. 2024, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, 42408869;36977687
• Design principles for strong and tough hydrogels
  Xueyu Li; Jian Ping Gong
  Nature Reviews Materials, 9, 380, 398, Springer Science and Business Media LLC, 07 May 2024, [Peer-reviewed], [Corresponding author], [International Magazine]
  English, Scientific journal, 36977687;42408869
• Effect of the Activation Force of Mechanophore on Its Activation Selectivity and Efficiency in Polymer Networks
  Zhi Jian Wang; Shu Wang; Julong Jiang; Yixin Hu; Tasuku Nakajima; Satoshi Maeda; Stephen L. Craig; Jian Ping Gong
  Journal of the American Chemical Society, 146, 19, 13336, 13346, American Chemical Society (ACS), 02 May 2024, [Peer-reviewed], [Last author, Corresponding author], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal, 42408869;36977687
• Tuning network structures of hydrophobic hydrogels by controlling polymerization solvent
  Hailong Fan; Daito Naohara; Wei Li; Xiang Li; Jian Ping Gong
  Polymer Chemistry, 15, 20, 2104, 2111, Royal Society of Chemistry (RSC), May 2024, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, Hydrophobic hydrogels with various copolymer sequences and network structures are prepared by tuning the solvent condition of the reaction solution, which exhibit different appearance and properties under the same monomer composition., 42408869;36977687
• Mapping deformation and dissipation during fracture of soft viscoelastic solid
  Yuan Qi; Xueyu Li; Sairam Pamulaparthi Venkata; Xingwei Yang; Tao Lin Sun; Chung-Yuen Hui; Jian Ping Gong; Rong Long
  Journal of the Mechanics and Physics of Solids, 186, 105595, 105595, Elsevier BV, May 2024, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal, 42408869
• Color-switching hydrogels as integrated microfluidic pressure sensors
  Lucie Ducloué; Md. Anamul Haque; Martyna Goral; Muhammad Ilyas; Jian Ping Gong; Anke Lindner
  Scientific Reports, 14, 1, Springer Science and Business Media LLC, 15 Mar. 2024, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal, Abstract
  
  Precisely measuring pressure in microfluidic flows is essential for flow control, fluid characterization, and monitoring, but faces specific challenges such as achieving sufficient resolution, non-invasiveness, or ease of use. Here, we demonstrate a fully integrated multiplexed optofluidic pressure sensor, entirely decoupled from the flow path, that enables local pressure measurements along any microfluidic channel without altering its flow geometry. The sensor itself relies on the compression of a soft mechano-actuated hydrogel, changing color in response to a pressure change. The hydrogel is separated from the fluid circulating in the channel by a thin membrane, allowing for the unrestricted use of different types of fluids. Imaging the gel through the transparent PDMS with a color camera provides a direct, easy, and contact-free determination of the fluid pressure at the sensing location for pressures as small as 20mbar with a resolution of around 10mbar. The sensitivity and accessible pressure range can be tuned via the mechanical properties of the sensing unit. The photonic gel can also be used to acquire 2D pressure or deformation maps, taking advantage of the fast response time and fine spatial resolution., 42408869;36977687
• Tough Hydroxyapatite Hydrogels Based on Bone-like Self-Regulatory Sacrificial Bond Formation
  Naohiro Kashimura; Yuki Suzuki; Takayuki Nonoyama; Jian Ping Gong
  Chemistry of Materials, 36, 6, 2944, 2952, American Chemical Society (ACS), 05 Mar. 2024, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, 42408869;36977687
• Spatial Analysis of the Damage Zone in Double Network Hydrogel Using the Microelectrode Technique
  Takuya Nishimura; Honglei Guo; Yoshinori Katsuyama; Masahiro Yoshida; Jian Ping Gong; Takayuki Kurokawa
  Macromolecules, 57, 4, 1502, 1508, American Chemical Society (ACS), 09 Feb. 2024, [Peer-reviewed], [International Magazine]
  English, Scientific journal, 42408869;36977687
• Effect of Predamage on the Fracture Energy of Double-Network Hydrogels
  Yong Zheng; Yiru Wang; Tasuku Nakajima; Jian Ping Gong
  ACS Macro Letters, 13, 2, 130, 137, American Chemical Society (ACS), 11 Jan. 2024, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, 42408869;36977687
• Role of hierarchy structure on the mechanical adaptation of self-healing hydrogels under cyclic stretching
  Xueyu Li; Kunpeng Cui; Yong Zheng; Ya Nan Ye; Chengtao Yu; Wenqi Yang; Tasuku Nakajima; Jian Ping Gong
  Science Advances, 9, 51, American Association for the Advancement of Science (AAAS), 20 Dec. 2023, [Peer-reviewed], [Lead author, Corresponding author], [International Magazine]
  English, Scientific journal, Soft materials with mechanical adaptability have substantial potential for various applications in tissue engineering. Gaining a deep understanding of the structural evolution and adaptation dynamics of soft materials subjected to cyclic stretching gives insight into developing mechanically adaptive materials. Here, we investigate the effect of hierarchy structure on the mechanical adaptation of self-healing hydrogels under cyclic stretching training. A polyampholyte hydrogel, composed of hierarchical structures including ionic bonds, transient and permanent polymer networks, and bicontinuous hard/soft-phase networks, is adopted as a model. Conditions for effective training, mild overtraining, and fatal overtraining are demonstrated in soft materials. We further reveal that mesoscale hard/soft-phase networks dominate the long-term memory effect of training and play a crucial role in the asymmetric dynamics of compliance changes and the symmetric dynamics of hydrogel shape evolution. Our findings provide insights into the design of hierarchical structures for adaptive soft materials.
• Azobenzene as a photoswitchable mechanophore
  Yiran Li; Bin Xue; Jiahui Yang; Julong Jiang; Jing Liu; Yanyan Zhou; Junsheng Zhang; Mengjiao Wu; Yuan Yuan; Zhenshu Zhu; Zhi Jian Wang; Yulan Chen; Yu Harabuchi; Tasuku Nakajima; Wei Wang; Satoshi Maeda; Jian Ping Gong; Yi Cao
  Nature Chemistry, Springer Science and Business Media LLC, 05 Dec. 2023, [Peer-reviewed], [Corresponding author], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal, 36977687
• Thermoresponsive Lamellar Hydrogels with Tunable Turbidity, Structural Color, and Anisotropic Swelling
  Yang Han; Yunzhou Guo; Tasuku Nakajima; Jian Ping Gong
  ACS Applied Materials & Interfaces, 15, 49, 57687, 57698, American Chemical Society (ACS), 29 Nov. 2023, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, 42408869;36977687
• Fractographic mirror law for brittle fracture of nonlinear elastic soft materials
  Ryuji Kiyama; Yong Zheng; Takayuki Nonoyama; Jian Ping Gong
  Soft Matter, 19, 40, 7724, 7730, Royal Society of Chemistry (RSC), Sep. 2023, [Peer-reviewed], [Corresponding author], [International Magazine]
  English, Scientific journal, The first fractographic mirror radius analysis for soft hydrogel materials was conducted. The universal −1 power law between fracture stress and mirror radius was established, in contrast to the different power law of linear elastic hard materials., 42408869;36977687
• Sustainable mechanochemical growth of double-network hydrogels supported by vascular-like perfusion
  Gumi Wei; Yumeko Kudo; Takahiro Matsuda; Zhi Jian Wang; Qi Feng Mu; Daniel R. King; Tasuku Nakajima; Jian Ping Gong
  Materials Horizons, 2023, 10, 4882, 4891, Royal Society of Chemistry (RSC), Aug. 2023, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, Double-network (DN) gels are unique mechanochemical materials owing to their structures that can be dynamically remodelled during use., 42408869;36977687
• Mechanical Reinforcement of Lamellar Bilayer Hydrogels by Small Amounts of Co-surfactants
  Milena Lama; Jian Ping Gong
  ACS Omega, 8, 28, 25185, 25194, American Chemical Society (ACS), 03 Jul. 2023, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, 42408869;36977687;42852235;11782741
• Origin of Surface Charge of Double Network Hydrogels Prepared by Sequential Polymerization
  Martin Frauenlob; Honglei Guo; Takayuki Kurokawa; Jian Ping Gong
  ACS macro letters, 56, 11, 860, 865, 20 Jun. 2023, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, Understanding the physicochemical properties of hydrogel surfaces and their molecular origins is important for their applications. In this paper, we elucidate the molecular origin of surface charges in double-network hydrogels synthesized by two-step sequential polymerization. Synthesis of hydrogels by free-radical polymerization does not fully complete the reaction, leaving a small number of unreacted monomers. When this approach is used to synthesize double network (DN) hydrogels by a two-step sequential polymerization from charged monomers for the first network and neutral monomers for the second network, the unreacted first network monomers are incorporated into the second network. Since the surface of such DN hydrogels is covered with a μm-thick layer of the neutral second network, the incorporation of a small amount of charged monomers into the second network increases the surface charge and, thereby, their repulsive/adhesive properties. Therefore, we propose a method to remove unreacted monomers and modulate the surface charge density of DN hydrogels., 42408869;36977687
• Swelling Effect on the Yielding, Elasticity, and Fracture of Double-Network Hydrogels with an Inhomogeneous First Network
  Yong Zheng; Tasuku Nakajima; Wei Cui; Chung-Yuen Hui; Jian Ping Gong
  Macromolecules, 56, 11, 3962, 3972, American Chemical Society (ACS), 17 May 2023, [Peer-reviewed], [Corresponding author], [International Magazine]
  English, Scientific journal, 42408869;36977687
• Inverse mechanical-swelling coupling of a highly deformed double-network gel
  Chika Imaoka; Tasuku Nakajima; Tsutomu Indei; Masaya Iwata; Wei Hong; Alba Marcellan; Jian Ping Gong
  Science Advances, 9, 19, American Association for the Advancement of Science (AAAS), 10 May 2023, [Peer-reviewed], [Last author], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal, Mechanical behaviors of a polymer gel are coupled with its swelling behavior. It has been known that typical hydrogels display extension-induced swelling and drying-induced stiffening, called normal mechanical-swelling coupling. In this study, we experimentally found that highly extended double-network (DN) hydrogels exhibit abnormal inverse mechanical-swelling coupling such as extension-induced deswelling and drying-induced softening. We established theoretical hyperelastic and swelling models that reproduced all the complicated mechanical and swelling trends of the highly deformed DN hydrogels. From these theoretical analyses, it is considered that the inverse mechanical-swelling coupling of a DN gel is derived from the extreme nonlinear elasticity of its first network at its ultimate deformation state. These findings contribute toward the understanding of the mechanics of rubber-like materials up to their ultimate deformation and fracture limit., 36977687
• Mechanical Model for Super-Anisotropic Swelling of the Multi-Cylindrical PDGI/PAAm Gels
  Tasuku Nakajima; Kei Mito; Jian Ping Gong
  Polymers, 15, 7, 1624, 1624, MDPI AG, 24 Mar. 2023, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, MC-PDGI/PAAm gels are cylindrical composite gels containing poly(dodecyl glyceryl itaconate) (PDGI) as a polymerized lipid oriented in a multilayer tubular shape within a polyacrylamide (PAAm) network. The most unique feature of the MC-PDGI/PAAm gel is its super-anisotropic swelling, wherein the diameter of the gel increases, but the length decreases with an increase in the volume of the gel. Through swelling and small-angle X-ray diffraction experiments, we investigated the effects of PDGI lipid bilayers and polymer network on the swelling of the MC-PDGI/PAAm gel, which suggests that the swelling anisotropy of the MC-PDGI/PAAm gel is dominated by the elasticity of the PDGI bilayers. Furthermore, we investigated the equation of state of the gel that roughly reproduced the experimental swelling results. These findings are crucial for realizing the controlled super-anisotropic swelling of MC-PDGI/PAAm gels and their applications as anisotropic actuation devices., 42408869;36977687;11782740
• In Situ and Real-Time Visualization of Mechanochemical Damage in Double-Network Hydrogels by Prefluorescent Probe via Oxygen-Relayed Radical Trapping
  Yong Zheng; Julong Jiang; Mingoo Jin; Daiyo Miura; Fei Xue Lu; Koji Kubota; Tasuku Nakajima; Satoshi Maeda; Hajime Ito; Jian Ping Gong
  Journal of the American Chemical Society, 145, 13, 7376, 7389, 23 Mar. 2023, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, Visualization of mechanochemical damages, especially for those in the molecular-scale (e.g., bond scission in polymeric materials), is of great industrial and academic significance. Herein, we report a novel strategy for in situ and real-time visualization of mechanochemical damages in hydrogels by utilizing prefluorescent probes via oxygen-relayed free-radical trapping. Double-network (DN) hydrogels that generate numerous mechanoradicals by homolytic bond scission of the brittle first network at large deformation are used as model materials. Theoretical calculation suggests that mechanoradicals generated by the damage of the first network undergo an oxygen-relayed radical-transfer process which can be detected by the prefluorescent probe through the radical-radical coupling reaction. Such an oxygen-relayed radical-trapping process of the prefluorescent probe exhibits a dramatically enhanced emission, which enables the real-time sensing and visualization of mechanochemical damages in DN hydrogels made from brittle networks of varied chemical structures. To the best of authors' knowledge, this work is the first report utilizing oxygen as a radical-relaying molecule for visualizing mechanoradical damages in polymer materials. Moreover, this new method based on the probe post-loading is simple and does not introduce any chemical structural changes in the materials, outperforming most previous methods that require chemical incorporation of mechanophores into polymer networks., 42408869;36977687
• 脳腫瘍に対する病理研究者としての克服戦略 ハイドロゲルによる髄膜腫幹細胞の探索(Strategies for overcoming the brain tumors presented by pathology researchers Search for meningioma stem cells using hydrogel)
  小田 義崇; 津田 真寿美; 湯澤 明夏; 王 磊; 鈴鹿 淳; ハビバ・ウンマ; 種井 善一; モーウリン・クリスチアン; グン 剣萍; 田中 伸哉
  日本病理学会会誌, 112, 1, 184, 184, (一社)日本病理学会, Mar. 2023, [Domestic magazines]
  English
• ハイドロゲルを用いた中皮腫幹細胞の創出および治療標的分子の探索
  加藤 万里絵; 杉野 弘和; 津田 真寿美; 王 磊; 種井 善一; 小田 義崇; 谷川 聖; グン 剣萍; 田中 伸哉
  日本病理学会会誌, 112, 1, 332, 332, (一社)日本病理学会, Mar. 2023, [Domestic magazines]
  Japanese
• Relaxation mechanisms in hydrogels with uniaxially oriented lamellar bilayers
  Anaïs Giustiniani; Muhammad Ilyas; Tsutomu Indei; Jian Ping Gong
  Polymer, 267, 125686, 125691, Elsevier BV, Feb. 2023, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, 36977687;11782741;11782740
• Geometrical analysis identified morphological features of hydrogel-induced cancer stem cells in synovial sarcoma model cells
  Zannatul Ferdous; Jean-Emmanuel Clément; Jian Ping Gong; Shinya Tanaka; Tamiki Komatsuzaki; Masumi Tsuda
  Biochemical and Biophysical Research Communications, 642, 41, 49, Elsevier BV, 29 Jan. 2023, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Cancer stem cells (CSCs) has been a key target to cure cancer patients completely. Although many CSC markers have been identified, they are frequently cancer type-specific and those expressions are occasionally variable, which becomes an obstacle to elucidate the characteristics of the CSCs. Here we scrutinized the relationship between stemness elevation and geometrical features of single cells. The PAMPS hydrogel was utilized to create the CSCs from mouse myoblast C2C12 and its synovial sarcoma model cells. qRT-PCR analysis confirmed the significant increase in expression levels of Sox2, Nanog, and Oct3/4 on the PAMPS gel, which was higher in the synovial sarcoma model cells. Of note, the morphological heterogeneity was appeared on the PAMPS gel, mainly including flat spreading, elongated spindle, and small round cells, and the Sox2 expression was highest in the small round cells. To examine the role of morphological differences in the elevation of stemness, over 6,400 cells were segmented along with the Sox2 intensity, and 12 geometrical features were extracted at single cell level. A nonlinear mapping of the geometrical features by using uniform manifold approximation and projection (UMAP) clearly revealed the existence of relationship between morphological differences and the stemness elevation, especially for C2C12 and its synovial sarcoma model on the PAMPS gel in which the small round cells possess relatively high Sox2 expression on the PAMPS gel, which supports the strong relationship between morphological changes and the stemness elevation. Taken together, these geometrical features can be useful for morphological profiling of CSCs to classify and distinguish them for understanding of their role in disease progression and drug discovery.
• Squid/synthetic polymer double-network gel: elaborated anisotropy and outstanding fracture toughness characteristics
  Shou Ohmura; Tasuku Nakajima; Masahiro Yoshida; Jian Ping Gong
  NPG Asia Materials, 15, 2, Springer Science and Business Media LLC, 20 Jan. 2023, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, Abstract
  
  The hierarchical anisotropy of a biotissue plays an essential role in its elaborate functions. To mimic the anisotropy-based functions of biotissues, soft and wet synthetic hydrogels with sophisticated biotissue-like anisotropy have been extensively explored. However, most existing synthetically manufactured anisotropic hydrogels exhibit fundamental anisotropy and poor mechanical toughness characteristics. In this paper, natural/synthetic hybrid double-network (DN) hydrogels with hierarchical anisotropy and high toughness characteristics are reported. These DN gels are prepared directly by using a squid mantle as an anisotropic soft bioproduct for the primary network and polyacrylamide (PAAm) as a synthetic polymer for the secondary network. The obtained squid/PAAm DN gel maintains the complex orientation of the muscle fibers of the squid mantle and exhibits anisotropic, enhanced mechanical properties and excellent fracture resistance due to its unique composite structure. This hybrid strategy provides a general method for preparing hydrogels with elaborated anisotropy and determining functions derived from the anisotropy., 36977687;11782740
• Rapid induction of reprogramming towards cancer stem cells by hydrogel
  田中伸哉; 鈴鹿 淳; 王 磊; 津田真寿美; 龔 剣萍
  細胞, 55, 1, 23, 25, Jan. 2023, [Invited], [Domestic magazines]
  Japanese, Scientific journal
• Effect of Salt on Dynamic Mechanical Behaviors of Polyampholyte Hydrogels
  Xueyu Li; Feng Luo; Tao Lin Sun; Kunpeng Cui; Reina Watanabe; Tasuku Nakajima; Jian Ping Gong
  Macromolecules, American Chemical Society (ACS), 16 Dec. 2022, [Peer-reviewed], [Last author, Corresponding author], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal, 36977687;11782740
• ERK MAP Kinase Signaling Regulates RAR Signaling to Confer Retinoid Resistance on Breast Cancer Cells
  Akira Hirota; Jean-Emmanuel Clément; Satoshi Tanikawa; Takayuki Nonoyama; Tamiki Komatsuzaki; Jian Ping Gong; Shinya Tanaka; Masamichi Imajo
  Cancers, 14, 23, 5890, 5890, MDPI AG, 29 Nov. 2022, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Retinoic acid (RA) and its synthetic derivatives, retinoids, have been established as promising anticancer agents based on their ability to regulate cell proliferation and survival. Clinical trials, however, have revealed that cancer cells often acquire resistance to retinoid therapy. Therefore, elucidation of underlying mechanisms of retinoid resistance has been considered key to developing more effective use of retinoids in cancer treatment. In this study, we show that constitutive activation of ERK MAP kinase signaling, which is often caused by oncogenic mutations in RAS or RAF genes, suppresses RA receptor (RAR) signaling in breast cancer cells. We show that activation of the ERK pathway suppresses, whereas its inhibition promotes, RA-induced transcriptional activation of RAR and the resultant upregulation of RAR-target genes in breast cancer cells. Importantly, ERK inhibition potentiates the tumor-suppressive activity of RA in breast cancer cells. Moreover, we also reveal that suppression of RAR signaling and activation of ERK signaling are associated with poor prognoses in breast cancer patients and represent hallmarks of specific subtypes of breast cancers, such as basal-like, HER2-enriched and luminal B. These results indicate that ERK-dependent suppression of RAR activity underlies retinoid resistance and is associated with cancer subtypes and patient prognosis in breast cancers.
• Computational Exploration of Polymer Mechanochemistry: Quantitation of Activation Force and Systematic Discovery of Reaction Sites Utilizing Two Forces
  Julong Jiang; Koji Kubota; Mingoo Jin; Zhi Jian Wang; Tasuku Nakajima; Hajime Ito; Jian Ping Gong; Satoshi Maeda
  American Chemical Society (ACS), 23 Nov. 2022
  A series of mechanophores were studied computationally by employing the AFIR (Artificial Force Induced Reaction) method, which applies an artificial force on the molecule to trigger reactions, and meanwhile with a tensile force to simulate a mechanochemical reaction. The calculation results were both qualitatively and quantitatively consistent to those reported experimentally, indicating that the AFIR is a reliable approach to studying mechanochemical reactions. It was then applied to the study of retro-Diels-Alder reactions for the theoretical predictions of activation force levels which are currently unavailable. Moreover, it also helped to reveal the favored geometry for the enhancement of force effect. Later, the AFIR method was employed to study the mechanodegradation of generic polymers. The substituents effect and the polymer tacticity in strengthening the mechanical responsiveness, were highlighted by our study. Given the importance of cross-linker molecules in the double-network (DN) hydrogels, a fully automatic search of mechanochemical transformation pathways of a commonly used cross-linker molecule, N,N'-methylenebisacrylamide (MBAA), was also performed by the AFIR method. Through the work described in this article, we demonstrated that, in the field of polymer mechanochemistry, the AFIR method utilizing two forces is a simple but effective tool to give accurate predictions of activation force levels at any given timescale. In the meantime, the mechanistic study of mechanochemical reactions shown in this article is believed to provide insightful suggestions for the further design and application of mechanophores.
• Load transfer between permanent and dynamic networks due to stress gradients in nonlinear viscoelastic hydrogels
  Jikun Wang; Kunpeng Cui; Bangguo Zhu; Jian Ping Gong; Chung-Yuen Hui; Alan T. Zehnder
  Extreme Mechanics Letters, 101928, 101928, Elsevier BV, 21 Nov. 2022, [Peer-reviewed], [Corresponding author], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal, 36977687;11782740;10240075
• Nanoscale TEM Imaging of Hydrogel Network Architecture
  Ryuji Kiyama; Masahiro Yoshida; Takayuki Nonoyama; Tomáš Sedlačík; Hiroshi Jinnai; Takayuki Kurokawa; Tasuku Nakajima; Jian Ping Gong
  Advanced Materials, 35, 1, 2208902, 2208902, Wiley, 09 Nov. 2022, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, 36977687;11782741;11782740
• How double dynamics affects the large deformation and fracture behaviors of soft materials
  Kunpeng Cui; Jian Ping Gong
  Journal of Rheology, 66, 6, 1093, 1111, Society of Rheology, 01 Nov. 2022, [Peer-reviewed], [Invited], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, Numerous mechanically strong and tough soft materials comprising of polymer networks have been developed over the last two decades, motivated by new high-tech applications in engineering and bio-related fields. These materials are characterized by their dynamic complexities and large deformation behaviors. In this Review, we focus on how chain dynamics affects the large deformation and fracture behaviors of soft materials. To favor readers without a rheology background, first we review the linear rheology behaviors of several simple networks. We show that, by playing with the physical entanglement, chemical cross-linking, and physical association of the building polymers, a very rich panel of dynamic responses can be obtained. Then, we show examples of how chain dynamics affects the deformation and fracture behaviors of dually cross-linked hydrogels having chemical cross-linkers and physical bonds. We also provide examples on the unique deformation behavior of physical double-network gels made from triblock polymers. Thereafter, examples of the influence of chain dynamics on the crack initiation and growth behaviors are presented. We show that even for chemically cross-linked double-network hydrogels that exhibit elastic behaviors in a common deformation window, the chain dynamics influences the damage zone size at the crack tip. Finally, we conclude this Review by proposing several directions for future research., 11782741;11782740
• Force-triggered rapid microstructure growth on hydrogel surface for on-demand functions
  Qifeng Mu; Kunpeng Cui; Zhi Jian Wang; Takahiro Matsuda; Wei Cui; Hinako Kato; Shotaro Namiki; Tomoko Yamazaki; Martin Frauenlob; Takayuki Nonoyama; Masumi Tsuda; Shinya Tanaka; Tasuku Nakajima; Jian Ping Gong
  Nature Communications, 13, 1, Springer Science and Business Media LLC, 20 Oct. 2022, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, Abstract
  
  Living organisms share the ability to grow various microstructures on their surface to achieve functions. Here we present a force stamp method to grow microstructures on the surface of hydrogels based on a force-triggered polymerisation mechanism of double-network hydrogels. This method allows fast spatial modulation of the morphology and chemistry of the hydrogel surface within seconds for on-demand functions. We demonstrate the oriented growth of cells and directional transportation of water droplets on the engineered hydrogel surfaces. This force-triggered method to chemically engineer the hydrogel surfaces provides a new tool in addition to the conventional methods using light or heat, and will promote the wide application of hydrogels in various fields., 36977687;11782740
• Rate-Independent Self-Healing Double Network Hydrogels Using a Thixotropic Sacrificial Network
  Tomoki Yasui; Yong Zheng; Tasuku Nakajima; Eiji Kamio; Hideto Matsuyama; Jian Ping Gong
  Macromolecules, 55, 21, 9547, 9557, American Chemical Society (ACS), 18 Oct. 2022, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, 11782740
• Gluing blood into gel by electrostatic interaction using a water-soluble polymer as an embolic agent
  Zhiping Jin; Hailong Fan; Toshiya Osanai; Takayuki Nonoyama; Takayuki Kurokawa; Hideki Hyodoh; Kotaro Matoba; Akiko Takeuchi; Jian Ping Gong; Miki Fujimura
  Proceedings of the National Academy of Sciences, 119, 42, e2206685119, Proceedings of the National Academy of Sciences, 18 Oct. 2022, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Liquid embolic agents are widely used for the endovascular embolization of vascular conditions. However, embolization based on phase transition is limited by the adhesion of the microcatheter to the embolic agent, use of an organic solvent, unintentional catheter retention, and other complications. By mimicking thrombus formation, a water-soluble polymer that rapidly glues blood into a gel without triggering coagulation was developed. The polymer, which consists of cationic and aromatic residues with adjacent sequences, shows electrostatic adhesion with negatively charged blood substances in a physiological environment, while common polycations cannot. Aqueous polymer solutions are injectable through clinical microcatheters and needles. The formed blood gel neither adhered to the catheter nor blocked the port. Postoperative computed tomography imaging showed that the polymer can block the rat femoral artery in vivo and remain at the injection site without nontarget embolization. This study provides an alternative for the development of waterborne embolic agents., 11782741;11782740
• Mechanism of temperature-induced asymmetric swelling and shrinking kinetics in self-healing hydrogels
  Kunpeng Cui; Chengtao Yu; Ya Nan Ye; Xueyu Li; Jian Ping Gong
  Proceedings of the National Academy of Sciences, 119, 36, e2207422119, Proceedings of the National Academy of Sciences, 06 Sep. 2022, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, Understanding the physical principle that governs the stimuli-induced swelling and shrinking kinetics of hydrogels is indispensable for their applications. Here, we show that the shrinking and swelling kinetics of self-healing hydrogels could be intrinsically asymmetric. The structure frustration, formed by the large difference in the heat and solvent diffusions, remarkably slows down the shrinking kinetics. The plateau modulus of viscoelastic gels is found to be a key parameter governing the formation of structure frustration and, in turn, the asymmetric swelling and shrinking kinetics. This work provides fundamental understandings on the temperature-triggered transient structure formation in self-healing hydrogels. Our findings will find broad use in diverse applications of self-healing hydrogels, where cooperative diffusion of water and gel network is involved. Our findings should also give insight into the molecular diffusion in biological systems that possess macromolecular crowding environments similar to self-healing hydrogels., 11782741;11782740
• ハイドロゲルを用いた髄膜腫がん幹細胞マーカーの検索(Identification of novel stemness marker of meningioma by using hydrogel)
  小田 義崇; 津田 真寿美; 湯澤 明夏; 王 磊; 谷川 聖; 種井 善一; グン 剣萍; 田中 伸哉
  日本癌学会総会記事, 81回, P, 2111, (一社)日本癌学会, Sep. 2022
  English
• Rapid Induction of Reprogramming Towards Cancer Stem Cells by Hydrogel as HARP Phenomenon
  田中伸哉; 鈴鹿 淳; 王 磊; 津田真寿美; 龔 剣萍
  BIO INDUSTRY, 39, 8, 40, 46, Aug. 2022, [Invited], [Domestic magazines]
  Japanese, Scientific journal
• Surfactant induced bilayer-micelle transition for emergence of functions in anisotropic hydrogel
  Md Anamul Haque; Takayuki Kurokawa; Tasuku Nakajima; Gen Kamita; Jian Ping Gong; Zannatul Fatema
  Journal of Materials Chemistry B, 10, 41, 8386, 8397, Royal Society of Chemistry (RSC), 23 Jun. 2022, [Peer-reviewed], [Last author, Corresponding author], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal, Tuning the self-assembled structures in amorphous hydrogels will enrich the functionality of hydrogels. In this study, we tuned the structure of a photonic hydrogel, which consists of polymeric lamellar bilayers..., 11782741;11782740
• Synthesis of degradable double network gels using a hydrolysable cross-linker
  Takanori Yokoi; Akinori Kuzuya; Tasuku Nakajima; Takayuki Kurokawa; Jian Ping Gong; Yuichi Ohya
  Polymer Chemistry, 13, 25, 3756, 3762, Royal Society of Chemistry (RSC), 02 Jun. 2022, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Double network (DN) gels have remarkably high mechanical strength and toughness and can be potentially applied in biomedical applications such as cartilage regeneration. However, most DN gels synthesised by usual...
• Role of Dynamic Bonds on Fatigue Threshold of Tough Hydrogels
  Xueyu Li; Jian Ping Gong
  Proceedings of the National Academy of Sciences, 119, 20, e2200678119, 12 May 2022, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, 11782740
• Evaluation of biological responses to micro-particles derived from a double network hydrogel
  Gen Matsumae; Mohamad Alaa Terkawi; Takayuki Nonoyama; Takayuki Kurokawa; Daisuke Takahashi; Tomohiro Shimizu; Ken Kadoya; Jian Ping Gong; Kazunori Yasuda; Norimasa Iwasaki
  Biomaterials Science, 10, 9, 2182, 2187, Royal Society of Chemistry (RSC), 16 Mar. 2022, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Double network hydrogels have been proven to be a substitute biomaterial for cartilage. For further applications as articular cartilages, it is essential to understand the biological reactions that might be initiated by their micro-particles., 11782740
• 細胞外基質の電位変化に伴うJCウイルス増殖の制御
  谷川 聖; 野々山 貴行; 津田 真寿美; 王 磊; 種井 善一; Gong Jian Ping; 田中 伸哉
  日本病理学会会誌, 111, 1, 263, 263, (一社)日本病理学会, Mar. 2022
  Japanese
• 細胞外基質の電位変化に伴うJCウイルス増殖の制御
  谷川 聖; 野々山 貴行; 津田 真寿美; 王 磊; 種井 善一; Gong Jian Ping; 田中 伸哉
  日本病理学会会誌, 111, 1, 263, 263, (一社)日本病理学会, Mar. 2022
  Japanese
• Engineering of an electrically charged hydrogel implanted into a traumatic brain injury model for stepwise neuronal tissue reconstruction
  Satoshi Tanikawa; Yuki Ebisu; Tomáš Sedlačík; Shingo Semba; Takayuki Nonoyama; Akira Hirota; Taiga Takahashi; Kazushi Yamaguchi; Masamichi Imajo; Hinako Kato; Takuya Nishimura; Zen-ichi Tanei; Masumi Tsuda; Tomomi Nemoto; Jian Ping Gong; Shinya Tanaka
  Scientific Reports, 13, 2233, Cold Spring Harbor Laboratory, 19 Feb. 2022, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Abstract
  
  Neural regeneration is extremely difficult to achieve. In traumatic brain injuries, the loss of brain parenchyma volume hinders neural regeneration. In this study, neuronal tissue engineering was performed by using electrically charged hydrogels composed of cationic and anionic monomers in a 1:1 ratio (C1A1 hydrogel), which served as an effective scaffold for the attachment of neural stem cells (NSCs). In the 3D environment of porous C1A1 hydrogels engineered by the cryogelation technique, NSCs differentiated into neuroglial cells. The C1A1 porous hydrogel was implanted into brain defects in a mouse traumatic damage model. The VEGF-immersed C1A1 porous hydrogel promoted host-derived vascular network formation together with the infiltration of macrophages/microglia and astrocytes into the gel. Furthermore, the stepwise transplantation of GFP-labeled NSCs supported differentiation to glial and neuronal cells. Therefore, this two-step method for neural regeneration may become a new approach for therapeutic brain tissue reconstruction after brain damage in the future.
  
  One Sentence Summary
  
  Brain tissue reconstruction using charged hydrogel and stepwise NCS injection
• Azo-Crosslinked Double-Network Hydrogels Enabling Highly Efficient Mechanoradical Generation
  Zhi Jian Wang; Julong Jiang; Qifeng Mu; Satoshi Maeda; Tasuku Nakajima; Jian Ping Gong
  Journal of the American Chemical Society, 144, 7, 3154, 3161, American Chemical Society (ACS), 11 Feb. 2022, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, 11782740
• Quantitative determination of cation–π interactions between metal ions and aromatic groups in aqueous media by a hydrogel Donnan potential method
  Hailong Fan; Honglei Guo; Takayuki Kurokawa; Jian Ping Gong
  Physical Chemistry Chemical Physics, 24, 10, 6126, 6132, Royal Society of Chemistry (RSC), Feb. 2022, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, The binding ratios of various metal ions to aromatic groups by cation–π interactions in aqueous media have been quantitatively calculated by using Donnan potential measurements., 11782740
• Facile preparation of cellulose hydrogel with Achilles tendon-like super strength through aligning hierarchical fibrous structure
  Yun Zhou Guo; Tasuku Nakajima; Md. Tariful Islam Mredha; Hong Lei Guo; Kunpeng Cui; Yong Zheng; Wei Cui; Takayuki Kurokawa; Jian Ping Gong
  Chemical Engineering Journal, 428, 132040, 132040, Elsevier BV, Jan. 2022, [Peer-reviewed], [Last author, Corresponding author], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal, 11782740
• Unique crack propagation of double network hydrogels under high stretch
  Ye Zhang; Kazuki Fukao; Takahiro Matsuda; Tasuku Nakajima; Katsuhiko Tsunoda; Takayuki Kurokawa; Jian Ping Gong
  Extreme Mechanics Letters, 51, 101588, 101588, Elsevier BV, 18 Dec. 2021, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, 11782740;24510616
• In Situ Evaluation of the Polymer Concentration Distribution of Microphase-Separated Polyelectrolyte Hydrogels by the Microelectrode Technique
  Takuya Nishimura; Honglei Guo; Ryuji Kiyama; Yoshinori Katsuyama; Jian Ping Gong; Takayuki Kurokawa
  Macromolecules, 54, 23, 10776, 10785, 14 Dec. 2021, [Peer-reviewed], [International Magazine]
  English, Scientific journal, 11782740
• How chain dynamics affects crack initiation in double-network gels
  Yong Zheng; Takahiro Matsuda; Tasuku Nakajima; Wei Cui; Ye Zhang; Chung-Yuen Hui; Takayuki Kurokawa; Jian Ping Gong
  Proceedings of the National Academy of Sciences, 118, 49, e2111880118, e2111880118, 07 Dec. 2021, [Peer-reviewed], [Last author, Corresponding author], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal, 11782740
• Bioinspired Underwater Adhesives
  Hailong Fan; Jian Ping Gong
  Advanced Materials, 33, 44, 2102983, 2102983, Wiley, 02 Nov. 2021, [Peer-reviewed], [Invited], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal
• Revisiting the Origins of the Fracture Energy of Tough Double-Network Hydrogels with Quantitative Mechanochemical Characterization of the Damage Zone
  Takahiro Matsuda; Runa Kawakami; Tasuku Nakajima; Yukiko Hane; Jian Ping Gong
  Macromolecules, 54, 22, 10331, 10339, American Chemical Society (ACS), 01 Nov. 2021, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, 11782740
• Hydroxyapatite‐hybridized double‐network hydrogel surface enhances differentiation of bone marrow‐derived mesenchymal stem cells to osteogenic cells
  Takuma Kaibara; Lei Wang; Masumi Tsuda; Takayuki Nonoyama; Takayuki Kurokawa; Norimasa Iwasaki; Jian Ping Gong; Shinya Tanaka; Kazunori Yasuda
  Journal of Biomedical Materials Research Part A, 110, 4, 747, 760, Wiley, 28 Oct. 2021, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Recently, we have developed a hydroxyapatite (HAp)-hybridized double-network (DN) hydrogel (HAp/DN gel), which can robustly bond to the bone tissue in the living body. The purpose of this study is to clarify whether the HAp/DN gel surface can differentiate the bone marrow-derived mesenchymal stem cells (MSCs) to osteogenic cells. We used the MSCs which were harvested from the rabbit bone marrow and cultured on the polystyrene (PS) dish using the autogenous serum-supplemented medium. First, we confirmed the properties of MSCs by evaluating colony forming unit capacity, expression of MSC markers using flow cytometry, and multidifferential capacity. Secondly, polymerase chain reaction analysis demonstrated that the HAp/DN gel surface significantly enhanced mRNA expression of the eight osteogenic markers (TGF-β1, BMP-2, Runx2, Col-1, ALP, OPN, BSP, and OCN) in the cultured MSCs at 7 days than the PS surfaces (p < 0.0001), while the DN gel and HAp surfaces provided no or only a slight effect on the expression of these markers except for Runx2. Additionally, the alkaline phosphatase activity was significantly higher in the cells cultured on the HAp/DN gel surface than in the other three material surfaces (p < 0.0001). Thirdly, when the HAp/DN gel plug was implanted into the rabbit bone marrow, MSC marker-positive cells were recruited in the tissue generated around the plug at 3 days, and Runx2 and OCN were highly expressed in these cells. In conclusion, this study demonstrated that the HAp/DN gel surface can differentiate the MSCs into osteogenic cells., 11782740
• Structure Frustration Enables Thermal History-Dependent Responsive Behavior in Self-Healing Hydrogels
  Chengtao Yu; Kunpeng Cui; Honglei Guo; Ya Nan Ye; Xueyu Li; Jian Ping Gong
  Macromolecules, 54, 21, 9927, 9936, 28 Oct. 2021, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, 11782741;11782740
• Toughening hydrogels through force-triggered chemical reactions that lengthen polymer strands
  Zi Wang; Xujun Zheng; Tetsu Ouchi; Tatiana B. Kouznetsova; Haley K. Beech; Sarah Av-Ron; Takahiro Matsuda; Brandon H. Bowser; Shu Wang; Jeremiah A. Johnson; Julia A. Kalow; Bradley D. Olsen; Jian Ping Gong; Michael Rubinstein; Stephen L. Craig
  Science, 374, 6564, 193, 196, American Association for the Advancement of Science (AAAS), 08 Oct. 2021, [Peer-reviewed], [Corresponding author], [International Magazine]
  English, Scientific journal, 11782740
• ハイドロゲルを用いた新規髄膜腫治療標的分子の検討(Analysis of novel therapeutic target for meningioma using hydrogel)
  小田 義崇; 津田 真寿美; 湯澤 明夏; 王 磊; Umma Habiba; 杉野 弘和; 種井 善一; グン 剣萍; 田中 伸哉
  日本病理学会会誌, 110, 2, 110, 110, (一社)日本病理学会, Oct. 2021
  English
• Rapid reprogramming of tumour cells into cancer stem cells on double-network hydrogel
  田中伸哉; 鈴鹿淳; 津田真寿美; 龔 剣萍; 高阪真路; 間野博行
  実験医学, 39, 14, 2255, 2259, Sep. 2021, [Invited], [Domestic magazines]
  Japanese, Scientific journal
• Tiny yet tough: Maximizing the toughness of fiber-reinforced soft composites in the absence of a fiber-fracture mechanism
  Wei Cui; Yiwan Huang; Liang Chen; Yong Zheng; Yoshiyuki Saruwatari; Chung-Yuen Hui; Takayuki Kurokawa; Daniel R. King; Jian Ping Gong
  Matter, 4, 11, 3646, 3661, Elsevier BV, Sep. 2021, [Peer-reviewed], [Last author, Corresponding author], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal, 11782740
• Facile tuning of hydrogel properties by manipulating cationic-aromatic monomer sequences
  Hailong Fan; Yirong Cai; Jian Ping Gong
  Science China Chemistry, 64, 9, 1560, 1568, Springer Science and Business Media LLC, Sep. 2021, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, 11782741;11782740
• Fast in vivo fixation of double network hydrogel to bone by monetite surface hybridization
  Takayuki NONOYAMA; Lei WANG; Ryuji KIYAMA; Naohiro KASHIMURA; Kazunori YASUDA; Shinya TANAKA; Takayuki KUROKAWA; Jian Ping GONG
  Journal of the Ceramic Society of Japan, 129, 9, 584, 589, 01 Sep. 2021, [Peer-reviewed], [Last author], [Domestic magazines]
  English, Scientific journal, 11782741;11782740
• Structure and unique functions of anisotropic hydrogels comprising uniaxially aligned lamellar bilayers
  Youfeng Yue; Jian Ping Gong
  Bulletin of the Chemical Society of Japan, 94, 9, 2221, 2234, The Chemical Society of Japan, 20 Jul. 2021, [Peer-reviewed], [Invited], [Last author, Corresponding author], [Domestic magazines]
  English, Scientific journal, 11782741;11782740
• A surface flattening method for characterizing the surface stress, drained Poisson’s ratio and diffusivity of poroelastic gels
  Zezhou Liu; Chung-Yuen Hui; Anand Jagota; Jian Ping Gong; Ryuji Kiyama
  Soft Matter, 17, 31, 7332, 7340, Royal Society of Chemistry (RSC), Jul. 2021, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal,

  When a poroelastic gel is released from a patterned mold, surface stress drives deformation and solvent migration in the gel and flattens its surface profile in a time-dependent manner. Specifically,...

  , 11782740
• Improving the strength and toughness of macroscale double networks by exploiting Poisson’s ratio mismatch
  Tsuyoshi Okumura; Riku Takahashi; Katsumi Hagita; Daniel R. King; Jian Ping Gong
  Scientific Reports, 11, 1, 13280, 13280, Springer Science and Business Media LLC, 24 Jun. 2021, [Peer-reviewed], [Last author], [International Magazine]
  English, Scientific journal, We propose a new concept that utilizes the difference in Poisson's ratio between component materials as a strengthening mechanism that increases the effectiveness of the sacrificial bond toughening mechanism in macroscale double-network (Macro-DN) materials. These Macro-DN composites consist of a macroscopic skeleton imbedded within a soft elastic matrix. We varied the Poisson's ratio of the reinforcing skeleton by introducing auxetic or honeycomb functional structures that results in Poisson’s ratio mismatch between the skeleton and matrix. During uniaxial tensile experiments, high strength and toughness were achieved due to two events: (1) multiple internal bond fractures of the skeleton (like sacrificial bonds in classic DN gels) and (2) significant, biaxial deformation of the matrix imposed by the functional skeleton. The Macro-DN composite with auxetic skeleton exhibits up to 4.2 times higher stiffness and 4.4 times higher yield force than the sum of the component materials. The significant improvement in mechanical performance is correlated to the large mismatch in Poisson's ratio between component materials, and the enhancement is especially noticeable in the low-stretch regime. The strengthening mechanism reported here based on Poisson's ratio mismatch can be widely used for soft materials regardless of chemical composition and will improve the mechanical properties of elastomer and hydrogel systems., 11782740
• Tough Double Network Hydrogel and Its Biomedical Applications
  Takayuki Nonoyama; Jian Ping Gong
  Annual Review of Chemical and Biomolecular Engineering, 12, 1, 393, 410, Annual Reviews, 07 Jun. 2021, [Peer-reviewed], [Invited], [Corresponding author], [International Magazine]
  English, Scientific journal, Soft and wet hydrogels have many similarities to biological tissues, though their mechanical fragility had been one of the biggest obstacles in biomedical applications. Studies and developments in double network (DN) hydrogels have elucidated how to create tough gels universally based on sacrificial bond principles and opened a path for biomedical application of hydrogels in regenerative medicine and artificial soft connective tissues, such as cartilage, tendon, and ligament, which endure high tension and compression. This review explores a universal toughening mechanism for and biomedical studies of DN hydrogels. Moreover, because the term sacrificial bonds has been mentioned often in studies of bone tissues, consisting of biomacromolecules and biominerals, recent studies of gel–biomineral composites to understand early-stage osteogenesis and to simulate bony sacrificial bonds are also summarized.
  
  Expected final online publication date for the Annual Review of Chemical and Biomolecular Engineering, Volume 12 is June 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates., 11782741;11782740
• Ultrapurified Alginate Gel Containing Bone Marrow Aspirate Concentrate Enhances Cartilage and Bone Regeneration on Osteochondral Defects in a Rabbit Model
  Liang Xu; Atsushi Urita; Tomohiro Onodera; Ryosuke Hishimura; Takayuki Nonoyama; Masanari Hamasaki; Dawei Liang; Kentaro Homan; Jian Ping Gong; Norimasa Iwasaki
  The American Journal of Sports Medicine, 49, 8, 2199, 2210, SAGE Publications, 01 Jun. 2021, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Ultrapurified alginate (UPAL) gel implantation has been demonstrated as effective in cartilage repair for osteochondral defects; however, cell transplantation within UPAL gels would be required to treat larger defects.
  
  The combination of UPAL gel and bone marrow aspirate concentrate (BMAC) would enhance cartilage repair and subchondral bone repair for large osteochondral defects.
  
  Controlled laboratory study.
  
  A total of 104 osteochondral defects (1 defect per knee) of 52 rabbits were randomly divided into 4 groups (26 defects per group): defects without any treatment (Defect group), defects treated using UPAL gel alone (UPAL group), defects treated using UPAL gel containing allogenic bone marrow mesenchymal stromal cells (UPAL-MSC group), and defects treated using UPAL gel containing BMAC (UPAL-BMAC group). At 4 and 16 weeks postoperatively, macroscopic and histologic evaluations and measurements of repaired subchondral bone volumes of reparative tissues were performed. Collagen orientation and mechanical properties of the reparative tissue were assessed at 16 weeks.
  
  The defects in the UPAL-BMAC group were repaired with hyaline-like cartilage with well-organized collagen structures. The histologic scores at 4 weeks were significantly higher in the UPAL-BMAC group (16.9 ± 2.0) than in the Defect group (4.7 ± 1.9; P < .05), the UPAL group (10.0 ± 3.3; P < .05), and the UPAL-MSC group (12.2 ± 2.9; P < .05). At 16 weeks, the score in the UPAL-BMAC group (24.4 ± 1.7) was significantly higher than those in the Defect group (9.0 ± 3.7; P < .05), the UPAL group (14.2 ± 3.9; P < .05), and the UPAL-MSC group (16.3 ± 3.6; P < .05). At 4 and 16 weeks, the macroscopic evaluations were significantly superior in the UPAL-BMAC group compared with the other groups, and the values of repaired subchondral bone volumes in the UPAL-BMAC group were significantly higher than those in the Defect and UPAL groups. The mechanical properties of the reparative tissues were significantly better in the UPAL-BMAC group than in the other groups.
  
  The implantation of UPAL gel containing BMAC-enhanced hyaline-like cartilage repair and subchondral bone repair of osteochondral defects in a rabbit knee model.
  
  These data support the potential clinical application of 1-step treatment for large osteochondral defects using biomaterial implantation with cell transplantation.
  
  
• Flower-like Photonic Hydrogel with Superstructure Induced via Modulated Shear Field
  Ya Nan Ye; Md Anamul Haque; Akane Inoue; Yoshinori Katsuyama; Takayuki Kurokawa; Jian Ping Gong
  ACS Macro Letters, 10, 6, 708, 713, 20 May 2021, [Peer-reviewed], [Corresponding author], [International Magazine]
  English, Scientific journal, 11782741;11782740
• Quantitative evaluation of macromolecular crowding environment based on translational and rotational diffusion using polarization dependent fluorescence correlation spectroscopy
  Johtaro Yamamoto; Akito Matsui; Fusako Gan; Makoto Oura; Riku Ando; Takahiro Matsuda; Jian Ping Gong; Masataka Kinjo
  Scientific Reports, 11, 1, 10594, 10594, Springer Science and Business Media LLC, 19 May 2021, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Macromolecular crowding (MMC) in cells is a hot topic in biology; therefore, well-characterized measurement standards for the evaluation of the nano-environment in MMC solutions are necessary. We propose to use polarization-dependent fluorescence correlation spectroscopy (Pol-FCS) for evaluation of macromolecular crowding in solutions. Pol-FCS can simultaneously measure the relaxation times of rotational and translational diffusion of fluorescent molecules at the same position, even in living cells with low damage. In this report, the differences in the nano-environment among solutions of small molecules, gels, and MMC solutions were evaluated by comparing their rotational and translational diffusion using Pol-FCS. Moreover, this method could distinguish the phase shift in the polyethylene glycol solution. Finally, we separately evaluated the nano-environment in the cytosol and nucleus of living cells in different cell lines and cell cycles. We expect this evaluation method to be useful in characterizing the nano-environment in MMC studies. In addition, the proposed method may be useful for other nano-environments such as liquid–liquid phase separation.
• Hierarchical toughening: A step toward matching the complexity of biological materials
  Daniel R. King; Jian Ping Gong
  Chem, 7, 5, 1153, 1155, May 2021, [Invited], [Last author], [International Magazine]
  English, Scientific journal
• Nanophase Separation in Immiscible Double Network Elastomers Induces Synergetic Strengthening, Toughening, and Fatigue Resistance
  Yong Zheng; Ryuji Kiyama; Takahiro Matsuda; Kunpeng Cui; Xueyu Li; Wei Cui; Yunzhou Guo; Tasuku Nakajima; Takayuki Kurokawa; Jian Ping Gong
  Chemistry of Materials, 33, 9, 3321, 3334, 19 Apr. 2021, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, 11782740
• Molecular mechanism of abnormally large nonsoftening deformation in a tough hydrogel
  Ya Nan Ye; Kunpeng Cui; Wei Hong; Xueyu Li; Chengtao Yu; Dominique Hourdet; Tasuku Nakajima; Takayuki Kurokawa; Jian Ping Gong
  Proceedings of the National Academy of Sciences, 118, 14, e2014694118, e2014694118, Proceedings of the National Academy of Sciences, 06 Apr. 2021, [Peer-reviewed], [Last author, Corresponding author], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal, Tough soft materials usually show strain softening and inelastic deformation. Here, we study the molecular mechanism of abnormally large nonsoftening, quasi-linear but inelastic deformation in tough hydrogels made of hyperconnective physical network and linear polymers as molecular glues to the network. The interplay of hyperconnectivity of network and effective load transfer by molecular glues prevents stress concentration, which is revealed by an affine deformation of the network to the bulk deformation up to sample failure. The suppression of local stress concentration and strain amplification plays a key role in avoiding necking or strain softening and endows the gels with a unique large nonsoftening, quasi-linear but inelastic deformation., 11782741;11782740
• Effect of mesoscale phase contrast on fatigue-delaying behavior of self-healing hydrogels
  Xueyu Li; Kunpeng Cui; Takayuki Kurokawa; Ya Nan Ye; Tao Lin Sun; Chengtao Yu; Costantino Creton; Jian Ping Gong
  Science Advances, 7, 16, eabe8210, eabe8210, American Association for the Advancement of Science (AAAS), Apr. 2021, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, We investigate the fatigue resistance of chemically cross-linked polyampholyte hydrogels with a hierarchical structure due to phase separation and find that the details of the structure, as characterized by SAXS, control the mechanisms of crack propagation. When gels exhibit a strong phase contrast and a low cross-linking level, the stress singularity around the crack tip is gradually eliminated with increasing fatigue cycles and this suppresses crack growth, beneficial for high fatigue resistance. On the contrary, the stress concentration persists in weakly phase-separated gels, resulting in low fatigue resistance. A material parameter, λ_tran, is identified, correlated to the onset of non-affine deformation of the mesophase structure in a hydrogel without crack, which governs the slow-to-fast transition in fatigue crack growth. The detailed role played by the mesoscale structure on fatigue resistance provides design principles for developing self-healing, tough, and fatigue-resistant soft materials., 11782740
• Experimental Verification of the Balance between Elastic Pressure and Ionic Osmotic Pressure of Highly Swollen Charged Gels
  Tasuku Nakajima; Ken-ichi Hoshino; Honglei Guo; Takayuki Kurokawa; Jian Ping Gong
  Gels, 7, 2, 39, 39, MDPI AG, 01 Apr. 2021, [Peer-reviewed], [Invited], [Last author], [International Magazine]
  English, Scientific journal, The equilibrium swelling degree of a highly swollen charged gel has been thought to be determined by the balance between its elastic pressure and ionic osmotic pressure. However, the full experimental verification of this balance has not previously been conducted. In this study, we verified the balance between the elastic pressure and ionic osmotic pressure of charged gels using purely experimental methods. We used tetra-PEG gels created using the molecular stent method (St-tetra-PEG gels) as the highly swollen charged gels to precisely and separately control their network structure and charge density. The elastic pressure of the gels was measured through the indentation test, whereas the ionic osmotic pressure was determined by electric potential measurement without any strong assumptions or fittings. We confirmed that the two experimentally determined pressures of the St-tetra-PEG gels were well balanced at their swelling equilibrium, suggesting the validity of the aforementioned relationship. Furthermore, from single-strand level analysis, we investigated the structural requirements of the highly swollen charged gels in which the elasticity and ionic osmosis are balanced at their swelling equilibrium., 11782740
• Rapid reprogramming of tumour cells into cancer stem cells on double-network hydrogels
  Jun Suzuka; Masumi Tsuda; Lei Wang; Shinji Kohsaka; Karin Kishida; Shingo Semba; Hirokazu Sugino; Sachiyo Aburatani; Martin Frauenlob; Takayuki Kurokawa; Shinya Kojima; Toshihide Ueno; Yoshihiro Ohmiya; Hiroyuki Mano; Kazunori Yasuda; Jian Ping Gong; Shinya Tanaka
  Nature Biomedical Engineering, 5, 8, 914, 925, Springer Science and Business Media LLC, 29 Mar. 2021, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Cancer recurrence can arise owing to rare circulating cancer stem cells (CSCs) that are resistant to chemotherapies and radiotherapies. Here, we show that a double-network hydrogel can rapidly reprogramme differentiated cancer cells into CSCs. Spheroids expressing elevated levels of the stemness genes Sox2, Oct3/4 and Nanog formed within 24 h of seeding the gel with cells from any of six human cancer cell lines or with brain cancer cells resected from patients with glioblastoma. Human brain cancer cells cultured on the double-network hydrogel and intracranially injected in immunodeficient mice led to higher tumorigenicity than brain cancer cells cultured on single-network gels. We also show that the double-network gel induced the phosphorylation of tyrosine kinases, that gel-induced CSCs from primary brain cancer cells were eradicated by an inhibitor of the platelet-derived growth factor receptor, and that calcium channel receptors and the protein osteopontin were essential for the regulation of gel-mediated induction of stemness in brain cancer cells.
• The Fracture of Highly Deformable Soft Materials: A Tale of Two Length Scales
  Rong Long; Chung-Yuen Hui; Jian Ping Gong; Eran Bouchbinder
  Annual Review of Condensed Matter Physics, 12, 1, 71, 94, Annual Reviews, 10 Mar. 2021, [Peer-reviewed], [Invited], [International Magazine]
  English, Scientific journal, The fracture of highly deformable soft materials is of great practical importance in a wide range of technological applications, emerging in fields such as soft robotics, stretchable electronics, and tissue engineering. From a basic physics perspective, the failure of these materials poses fundamental challenges due to the strongly nonlinear and dissipative deformation involved. In this review, we discuss the physics of cracks in soft materials and highlight two length scales that characterize the strongly nonlinear elastic and dissipation zones near crack tips in such materials. We discuss physical processes, theoretical concepts, and mathematical results that elucidate the nature of the two length scales and show that the two length scales can classify a wide range of materials. The emerging multiscale physical picture outlines the theoretical ingredients required for the development of predictive theories of the fracture soft materials. We conclude by listing open challenges and future investigation directions.
  
  Expected final online publication date for the Annual Review of Condensed Matter Physics, Volume 12 is March 10, 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates., 11782740
• 忘却能力を持つ動的記憶素子の構築～人間の脳の動的な記憶・忘却挙動に触発されて～
  崔 昆朋; 龔 剣萍
  超分子研究会アニュアルレビュー, 41, 12, 13, Mar. 2021, [Invited], [Last author]
  Japanese, Scientific journal
• 新陳代謝して成長するゲル
  中島 祐; 龔剣萍
  化学と教育, 69, 3, 94, 97, Mar. 2021, [Invited], [Last author]
  Japanese, Scientific journal
• Constitutive modeling of strain-dependent bond breaking and healing kinetics of chemical polyampholyte (PA) gel
  Sairam Pamulaparthi Venkata; Kunpeng Cui; Jingyi Guo; Alan T. Zehnder; Jian Ping Gong; Chung-Yuen Hui
  Soft Matter, 17, 15, 4161, 4169, Royal Society of Chemistry (RSC), Mar. 2021, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal,

  A finite strain nonlinear viscoelastic constitutive model is used to study the uniaxial tension behaviour of a chemical polyampholyte (PA) gel.

  , 11782740
• Ultrahigh‐Water‐Content Photonic Hydrogels with Large Electro‐Optic Responses in Visible to Near‐Infrared Region
  Youfeng Yue; Yasuo Norikane; Jian Ping Gong
  Advanced Optical Materials, 9, 9, 2002198, 2002198, 16 Feb. 2021, [Peer-reviewed], [Last author]
  English, Scientific journal, 11782741
• Aggregated structures and their functionalities in hydrogels
  Kunpeng Cui; Jian Ping Gong
  Aggregate, 2, 2, e33, Wiley, 13 Feb. 2021, [Peer-reviewed], [Invited], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, 11782740
• Constitutive modeling of bond breaking and healing kinetics of physical Polyampholyte (PA) gel
  Sairam Pamulaparthi Venkata; Kunpeng Cui; Jingyi Guo; Alan T. Zehnder; Jian Ping Gong; Chung-Yuen Hui
  Extreme Mechanics Letters, 43, 101184, 101184, Elsevier BV, Feb. 2021, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal, 11782740
• Barnacle Cement Proteins‐Inspired Tough Hydrogels with Robust, Long‐Lasting, and Repeatable Underwater Adhesion
  Hailong Fan; Jiahui Wang; Jian Ping Gong
  Advanced Functional Materials, 31, 11, 2009334, 2009334, Wiley, 28 Dec. 2020, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, 11782740
• 骨リモデリングプロセスを利用したハイドロゲルの骨への高強度接着―人工軟骨への応用に向けて
  樫村尚宏; 野々山貴行; 龔剣萍
  医学のあゆみ, 275, 11, 1203, 1209, 12 Dec. 2020, [Invited], [Last author]
  Japanese, Scientific journal
• Correction to Preparation of Tough Double- and Triple-Network Supermacroporous Hydrogels through Repeated Cryogelation
  Tomáš Sedlačík; Takayuki Nonoyama; Honglei Guo; Ryuji Kiyama; Tasuku Nakajima; Yoshihiro Takeda; Takayuki Kurokawa; Jian Ping Gong
  Chemistry of Materials, 32, 24, 10737, 10737, American Chemical Society (ACS), 07 Dec. 2020, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, 11782740;11782741
• Isotope Microscopic Observation of Osteogenesis Process Forming Robust Bonding of Double Network Hydrogel to Bone.
  Takayuki Nonoyama; Lei Wang; Masumi Tsuda; Yuki Suzuki; Ryuji Kiyama; Kazunori Yasuda; Shinya Tanaka; Kousuke Nagata; Ryosuke Fujita; Naoya Sakamoto; Noriyuki Kawasaki; Hisayoshi Yurimoto; Jian Ping Gong
  Advanced healthcare materials, 10, 3, 2001731, 16 Nov. 2020, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, Tough double network (DN) hydrogels are promising substitutes of soft supporting tissues such as cartilage and ligaments. For such applications, it is indispensable to robustly fix the hydrogels to bones with medically feasible methods. Recently, robustly bonding the DN hydrogels to defected bones of rabbits in vivo has been proved successful. The low crystalline hydroxyapatite (HAp) of calcium-phosphate-hydroxide salt coated on the surface layer of the DN hydrogels induced spontaneous osteogenesis penetrating into the semi-permeable hydrogels to form a gel/bone composite layer. In this work, the 44 Ca isotope-doped HAp/DN hydrogel is implanted in a defect of rabbit femoral bone and the dynamic osteogenesis process at the gel/bone interface is analyzed by tracing the calcium isotope ratio using isotope microscopy. The synthetic HAp hybridized on the surface layer of DN gel dissolves rapidly in the first two weeks by inflammation, and then the immature bone with a gradient structure starts to form in the gel region, reutilizing the dissolved Ca ions. These results reveal, for the first time, that synthetic HAp is reutilized for osteogenesis. These facts help to understand the lifetime of bone absorbable materials and to elucidate the mechanism of spontaneous, non-toxic, but strong fixation of hydrogels to bones., 11782741;11782740
• Micromechanical modeling of the multi-axial deformation behavior in double network hydrogels
  Rui Xiao; Thanh-Tam Mai; Kenji Urayama; Jian Ping Gong; Shaoxing Qu
  International Journal of Plasticity, 137, 102901, 102901, Elsevier BV, Nov. 2020, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal
• How surface stress transforms surface profiles and adhesion of rough elastic bodies
  Chung-Yuen Hui; Zezhou Liu; Nicolas Bain; Anand Jagota; Eric R. Dufresne; Robert W. Style; Ryuji Kiyama; Jian Ping Gong
  Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences, 476, 2243, 20200477, 20200477, The Royal Society, Nov. 2020, [Peer-reviewed], [Last author], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal, The surface of soft solids carries a surface stress that tends to flatten surface profiles. For example, surface features on a soft solid, fabricated by moulding against a stiff-patterned substrate, tend to flatten upon removal from the mould. In this work, we derive a transfer function in an explicit form that, given any initial surface profile, shows how to compute the shape of the corresponding flattened profile. We provide analytical results for several applications including flattening of one-dimensional and two-dimensional periodic structures, qualitative changes to the surface roughness spectrum, and how that strongly influences adhesion., 11782740
• Stress Relaxation and Underlying Structure Evolution in Tough and Self-Healing Hydrogels
  Kunpeng Cui; Ya Nan Ye; Chengtao Yu; Xueyu Li; Takayuki Kurokawa; Jian Ping Gong
  ACS Macro Letters, 9, 11, 1582, 1589, 22 Oct. 2020, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, 11782740
• Polyzwitterions as a Versatile Building Block of Tough Hydrogels: From Polyelectrolyte Complex Gels to Double-Network Gels
  Haiyan Yin; Daniel R. King; Tao Lin Sun; Yoshiyuki Saruwatari; Tasuku Nakajima; Takayuki Kurokawa; Jian Ping Gong
  ACS Applied Materials & Interfaces, 12, 44, 50068, 50076, American Chemical Society (ACS), 21 Oct. 2020, [Peer-reviewed], [Last author, Corresponding author], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal, The high water content of hydrogels makes them important as synthetic biomaterials, and tuning the mechanical properties of hydrogels to match those of natural tissues without changing chemistry is usually difficult. In this study, we have developed a series of hydrogels with varied stiffness, strength, and toughness based on a combination of poly(2-acrylamido-2-methylpropane sulfonic acid) (PAMPS), a strong acidic polyelectrolyte, and poly-N-(carboxymethyl)-N,N-dimethyl-2-(methacryloyloxy) ethanaminium) (PCDME), a polyzwitterion with a weak acidic moiety. We demonstrate that modifying the true molar ratio, R, of PCDME to PAMPS results in four unique categories of hydrogels with different swelling ratios and Young's moduli. When R < 1, a negatively charged polyelectrolyte gel (PE) is formed; when 1 < R < 3, a tough and viscoelastic polyelectrolyte complex gel (PEC) is formed; when 3 < R < 6.5, a conventional, elastic interpenetrating network gel (IPN) is formed; and when R > 6.5, a tough and stiff double-network gel (DN) is formed. Both the PEC and DN gels exhibit high toughness and fracture stress, up to 1.8 and 1.5 MPa, respectively. Importantly, the PEC gels exhibit strong recovery properties along with high toughness, distinguishing them from DN gels. Without requiring a change in chemistry, we can tune the mechanical response of hydrogels over a wide spectrum, making this a useful system of soft and hydrated biomaterials., 11782740
• Chitin-Based Double-Network Hydrogel as Potential Superficial Soft-Tissue-Repairing Materials
  Junchao Huang; Martin Frauenlob; Yuki Shibata; Lei Wang; Tasuku Nakajima; Takayuki Nonoyama; Masumi Tsuda; Shinya Tanaka; Takayuki Kurokawa; Jian Ping Gong
  Biomacromolecules, 21, 10, 4220, 4230, American Chemical Society (ACS), 27 Sep. 2020, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, Chitin is a biopolymer, which has been proven to be a biomedical material candidate, yet the weak mechanical properties seriously limit their potentials. In this work, a chitin-based double-network (DN) hydrogel has been designed as a potential superficial repairing material. The hydrogel was synthesized through a double-network (DN) strategy composing hybrid regenerated chitin nanofiber (RCN)-poly (ethylene glycol diglycidyl ether) (PEGDE) as the first network and polyacrylamide (PAAm) as the second network. The hybrid RCN-PEGDE/PAAm DN hydrogel was strong and tough, possessing Young's modulus (elasticity) E 0.097 ± 0.020 MPa, fracture stress σf 0.449 ± 0.025 MPa, and work of fracture Wf 5.75 ± 0.35 MJ·m-3. The obtained DN hydrogel was strong enough for surgical requirements in the usage of soft tissue scaffolds. In addition, chitin endowed the DN hydrogel with good bacterial resistance and accelerated fibroblast proliferation, which increased the NIH3T3 cell number by nearly five times within 3 days. Subcutaneous implantation studies showed that the DN hydrogel did not induce inflammation after 4 weeks, suggesting a good biosafety in vivo. These results indicated that the hybrid RCN-PEGDE/PAAm DN hydrogel had great prospect as a rapid soft-tissue-repairing material., 11782740
• Crack Tip Field of a Double-Network Gel: Visualization of Covalent Bond Scission through Mechanoradical Polymerization
  Takahiro Matsuda; Runa Kawakami; Tasuku Nakajima; Jian Ping Gong
  Macromolecules, 53, 20, 8787, 8795, American Chemical Society (ACS), 25 Sep. 2020, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, 11782740
• Preparation of Tough Double- and Triple-Network Supermacroporous Hydrogels through Repeated Cryogelation
  Tomáš Sedlačík; Takayuki Nonoyama; Honglei Guo; Ryuji Kiyama; Tasuku Nakajima; Yoshihiro Takeda; Takayuki Kurokawa; Jian Ping Gong
  Chemistry of Materials, 32, 19, 8576, 8586, American Chemical Society (ACS), 04 Sep. 2020, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, 11782741;11782740
• High-Fidelity Hydrogel Thin-Films Processed from Deep Eutectic Solvents
  David Delgado; Daniel Rudolf King; KUNPENG CUI; Jian Ping Gong; Kenneth R Shull
  ACS Applied Materials & Interfaces, 12, 38, 43191, 43200, American Chemical Society (ACS), 21 Aug. 2020, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal, 11782740
• Effect of the constituent networks of double-network gels on their mechanical properties and energy dissipation process
  Tasuku Nakajima; Takayuki Kurokawa; Hidemitsu Furukawa; Jian Ping Gong
  Soft Matter, 16, 37, 8618, 8627, Royal Society of Chemistry (RSC), 07 Aug. 2020, [Peer-reviewed], [Last author], [International Magazine]
  English, Scientific journal,

  The relationship between composition and mechanical properties of tough double-network hydrogels was clarified by systematic experiments and theoretical investigations.

  , 11782740
• バイオマテリアルによる肝癌幹細胞の新規誘導法の開発とその解析
  谷 道夫; 津田 真寿美; 鈴鹿 淳; 王 磊; 杉野 弘和; 谷川 聖; 石田 雄介; グン 剣萍; 田中 伸哉; 武冨 紹信
  日本外科学会定期学術集会抄録集, 120回, DP, 6, (一社)日本外科学会, Aug. 2020
  Japanese
• バイオマテリアルによる肝癌幹細胞の新規誘導法の開発とその解析
  谷 道夫; 津田 真寿美; 鈴鹿 淳; 王 磊; 杉野 弘和; 谷川 聖; 石田 雄介; グン 剣萍; 田中 伸哉; 武冨 紹信
  日本外科学会定期学術集会抄録集, 120回, DP, 6, (一社)日本外科学会, Aug. 2020
  Japanese
• Hydrogels as dynamic memory with forgetting ability
  Chengtao Yu; Honglei Guo; Kunpeng Cui; Xueyu Li; Ya Nan Ye; Takayuki Kurokawa; Jian Ping Gong
  Proceedings of the National Academy of Sciences, 117, 32, 202006842, 202006842, Proceedings of the National Academy of Sciences, 27 Jul. 2020, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, The memory of our brain, stored in soft matter, is dynamic, and it forgets spontaneously to filter unimportant information. By contrast, the existing manmade memory, made from hard materials, is static, and it does not forget without external stimuli. Here we propose a principle for developing dynamic memory from soft hydrogels with temperature-sensitive dynamic bonds. The memorizing–forgetting behavior is achieved based on fast water uptake and slow water release upon thermal stimulus, as well as thermal-history-dependent transparency change of these gels. The forgetting time is proportional to the thermal learning time, in analogy to the behavior of brain. The memory is stable against temperature fluctuation and large stretching; moreover, the forgetting process is programmable. This principle may inspire future research on dynamic memory based on the nonequilibrium process of soft matter., 11782741;11782740
• Bactericidal effect of cationic hydrogels prepared from hydrophilic polymers
  Yuki Shibata; Takayuki Kurokawa; Tomoyasu Aizawa; Jian Ping Gong
  Journal of Applied Polymer Science, 137, 48, 49583, 49583, Wiley, 24 Jul. 2020, [Peer-reviewed], [Last author], [International Magazine]
  English, Scientific journal, 11782740
• Phase Separation Behavior in Tough and Self-Healing Polyampholyte Hydrogels
  Kunpeng Cui; Ya Nan Ye; Tao Lin Sun; Chengtao Yu; Xueyu Li; Takayuki Kurokawa; Jian Ping Gong
  Macromolecules, 53, 13, 5116, 5126, American Chemical Society (ACS), 26 Jun. 2020, [Peer-reviewed], [Last author, Corresponding author], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal, 11782740
• Fiber‐Reinforced Viscoelastomers Show Extraordinary Crack Resistance That Exceeds Metals
  Wei Cui; Daniel R. King; Yiwan Huang; Liang Chen; Tao Lin Sun; Yunzhou Guo; Yoshiyuki Saruwatari; Chung‐Yuen Hui; Takayuki Kurokawa; Jian Ping Gong
  Advanced Materials, 32, 31, 1907180, 1907180, Wiley, 25 Jun. 2020, [Peer-reviewed], [Last author, Corresponding author], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal, Soft fiber-reinforced polymers (FRPs), consisting of rubbery matrices and rigid fabrics, are widely utilized in industry because they possess high specific strength in tension while allowing flexural deformation under bending or twisting. Nevertheless, existing soft FRPs are relatively weak against crack propagation due to interfacial delamination, which substantially increases their risk of failure during use. In this work, a class of soft FRPs that possess high specific strength while simultaneously showing extraordinary crack resistance are developed. The strategy is to synthesize tough viscoelastic matrices from acrylate monomers in the presence of woven fabrics, which generates soft composites with a strong interface and interlocking structure. Such composites exhibit fracture energy, Γ, of up to 2500 kJ m-2 , exceeding the toughest existing materials. Experimental elucidation shows that the fracture energy obeys a simple relation, Γ = W · lT , where W is the volume-weighted average of work of extension at fracture of the two components and lT is the force transfer length that scales with the square root of fiber/matrix modulus ratio. Superior Γ is achieved through a combination of extraordinarily large lT (10-100 mm), resulting from the extremely high fiber/matrix modulus ratios (104 -105 ), and the maximized energy dissipation density, W. The elucidated quantitative relationship provides guidance toward the design of extremely tough soft composites., 11782741;11782740
• Lamellar Bilayer to Fibril Structure Transformation of Tough Photonic Hydrogel under Elongation
  M. Anamul Haque; Kunpeng Cui; Muhammad Ilyas; Takayuki Kurokawa; Alba Marcellan; Annie Brulet; Riku Takahashi; Tasuku Nakajima; J. Ping Gong
  Macromolecules, 53, 12, 4711, 4721, American Chemical Society (ACS), 12 Jun. 2020, [Peer-reviewed], [Last author, Corresponding author], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal, 11782741;11782740
• Synthetic PAMPS Gel Induces Chondrogenic Differentiation of ATDC5 Cells via a Novel Protein Reservoir Function
  Shingo Semba; Nobuto Kitamura; Masumi Tsuda; Keiko Goto; Sadamu Kurono; Yoshihiro Ohmiya; Takayuki Kurokawa; Jian Ping Gong; Kazunori Yasuda; Shinya Tanaka
  Journal of Biomedical Materials Research Part A, 109, 3, 354, 364, 04 Jun. 2020, [Peer-reviewed], [International Magazine]
  English, Scientific journal, We previously demonstrated that a synthetic negatively charged poly(2-acrylamido-2-methylpropanesulfonic acid) (PAMPS) gel induced chondrogenic differentiation of ATDC5 cells. In this study, we clarified the underlying molecular mechanism, in particular, focusing on the events that occurred at the interface between the gel and the cells. Gene expression profiling revealed that the expression of extracellular components was enhanced in the ATDC5 cells that were cultured on the PAMPS gel, suggesting that extracellular proteins secreted from the ATDC5 cells might be adsorbed in the PAMPS gel, thereby contributing to the induction of chondrogenic differentiation. Therefore, we created "Treated-PAMPS gel," which adsorbed various proteins secreted from the cultured ATDC5 cells during 7 days. Proteomic analysis identified 27 proteins, including extracellular matrix proteins such as Types I, III, and V collagens and thrombospondin (THBS) in the Treated-PAMPS gel. The Treated-PAMPS gel preferentially induced expression of chondrogenic markers, namely, aggrecan and Type II collagen, in the ATDC5 cells compared with the untreated PAMPS gel. Addition of recombinant THBS1 to the ATDC5 cells significantly enhanced the PAMPS-induced chondrogenic differentiation, whereas knockdown of THBS1 completely abolished this response. In conclusion, we demonstrated that the PAMPS gel has the potential to induce chondrogenic differentiation through novel reservoir functions, and the adsorbed THBS plays a significant role in the induction.
• Integrin α4 Mediates ATDC5 Cell Adhesion to Negatively Charged Synthetic Polymer Hydrogel Leading to Chondrogenic Differentiatio
  Daiki Hashimoto; Shingo Semba; Masumi Tsuda; Takayuki Kurokawa; Nobuto Kitamura; Kazunori Yasuda; Jian Ping Gong; Shinya Tanaka
  Biochemical and Biophysical Research Communications, 528, 1, 120, 126, 23 May 2020, [Peer-reviewed], [International Magazine]
  English, Scientific journal, Negatively charged synthetic hydrogels have been known to facilitate various cellular responses including cell adhesion, proliferation, and differentiation; however, the molecular mechanism of hydrogel-dependent control of cell behavior remains unclear. Recently, we reported that negatively charged poly(2-acrylamido-2-methylpropanesulfonic acid) (PAMPS) gel induces chondrogenic differentiation of ATDC5 cells via novel protein reservoir function. In this study, we identified the cell adhesion molecules binding to PAMPS gels that act as mechanoreceptors. First, we performed a pull-down assay by particle gels using cell membrane proteins of ATDC5, and found that multiple membrane proteins bound to the PAMPS gel, whereas the uncharged poly(N,N'-dimethylacrylamide) gel as control did not bind to any membrane proteins. Western blot analysis indicated differential binding of integrin (ITG) isoforms to the PAMPS gel, in which the α4 isoform, but not α5 and αv, efficiently bound to the PAMPS gel. ITG α4 knockdown decreased cell spreading of ATDC5 on PAMPS gels, whereas the enhanced expression increased the behavior. Furthermore, ITG α4 depletion suppressed PAMPS gel-induced expression of bone morphogenic protein (BMP) 4 contributing to chondrogenic differentiation, in concordance with the reduction of ERK activation. These results demonstrated that membrane protein binding to PAMPS gels occurred in a charge-dependent manner, and that ITG α4 plays a crucial role in cell spreading on PAMPS gels and acts as a mechanoreceptor triggering cellular signaling leads to chondrogenic differentiation.
• Anisotropic Double Network Hydrogels via Controlled Orientation of a Physical Sacrificial Network
  Daniel R. King; Riku Takahashi; Takuma Ikai; Kazuki Fukao; Takayuki Kurokawa; Jian Ping Gong
  ACS Applied Polymer Materials, 2, 6, 2350, 2358, 15 May 2020, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, 11782740;24510616
• Double-Network Gels as Polyelectrolyte Gels with Salt-Insensitive Swelling Properties
  Tasuku Nakajima; Takaharu Chida; Kei Mito; Taayuki Kurokawa; Jian Ping Gong
  Soft Matter, 16, 23, 5487, 5496, 15 May 2020, [Peer-reviewed], [Last author], [International Magazine]
  English, Scientific journal, Polyelectrolyte gels exhibit intrinsic salt-sensitive swelling behaviour, which causes size instability in ionic environments. Thus, polyelectrolyte gels that show salt-insensitive swelling have been anticipated for applications in ionic environments, such as medical materials used in vivo. We found that double-network (DN) gels consisting of both a polyelectrolyte network and a non-ionic network are resistant to salt-sensitive swelling. This resistance is attributed to their lower osmotic pressure originating from mobile ions relative to the osmotic pressure of mixing at swelling equilibrium. Our investigation indicated that the two contrasting network structures within the DN gels are vital for achieving these properties, where the structures include a highly prestretched and sparse polyelectrolyte network and a coiled and dense non-ionic network. The salt-insensitivity of the DN gels will lead to their unique applications in ionic environments., 11782740
• Hydrogels Toughened by Biominerals as Energy-Dissipative Sacrificial Bonds
  Kazuki Fukao; Kazuki Tanaka; Ryuji Kiyama; Takayuki Nonoyama; Jian Ping Gong
  Journal of Materials Chemistry B, 8, 24, 5184, 5188, 06 May 2020, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, Inspired by bone tissues, we mineralized low crystalline hydroxyapatite (HAp) particles in double network (DN) hydrogels, and we observed that the HAp minerals toughen the gels. The contribution of dissipated energy from HAp minerals was over 500% higher than that from the polymer during tensile deformation. We elucidated that the amorphous parts in the HAp minerals break at deformation, acting as energy-dissipative sacrificial bonds. This result implies that not only brittle polymer networks but also minerals can provide sacrificial bonds to toughen soft materials., 11782741;11782740;24510616
• Competitive Cation−π Interactions Between Small Cations and Polycations with Phenyl Groups in Poly(Cation−π) Hydrogels
  Hailong Fan, Honglei Guo, Jiahui Wang, Jian Ping Gong
  Giant, 1, 100005, 100005, Elsevier BV, Apr. 2020, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, 11782740
• Fabrication of Bioinspired Hydrogels: Challenges and Opportunities
  Hailong Fan; Jian Ping Gong
  Macromolecules, 53, 8, 2769, 2782, Apr. 2020, [Peer-reviewed], [Invited], [Last author, Corresponding author]
  English, Scientific journal, 11782740;11782741
• 人工軟骨を目指した高強度ハイドロゲル－リン酸カルシウムの複合化および骨との接着
  Takayuki Nonoyama; Ryuji Kiyama; Kazuki Fukao; Kazunori Yasuda; Takayuki Kurokawa; Jian Ping Gong
  Ceramics Japan, 55, 3, 166, 170, 日本セラミックス協会, Mar. 2020, [Invited], [Last author]
  Japanese, Scientific journal
• Meet the phase-separation polymeric gel
  Takayuki Nonoyama; Jian Ping Gong
  The Innovation Platform, 1, 73, 74, Mar. 2020, [Invited], [Last author], [International Magazine]
  English, Scientific journal
• Mesoscale Bicontinuous Networks in Self-healing Hydrogels Delay Fatigue Fracture
  Xueyu Li; Kunpeng Cui; Tao Lin Sun; Lingpu Meng; Chengtao Yu; Liangbin Li; Costantino Creton; Takayuki Kurokawa; Jian Ping Gong
  Proceedings of the National Academy of Sciences, 117, 14, 7606, 7612, Mar. 2020, [Peer-reviewed], [Last author, Corresponding author], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal, Load-bearing biological tissues, such as muscles, are highly fatigue-resistant, but how the exquisite hierarchical structures of biological tissues contribute to their excellent fatigue resistance is not well understood. In this work, we study antifatigue properties of soft materials with hierarchical structures using polyampholyte hydrogels (PA gels) as a simple model system. PA gels are tough and self-healing, consisting of reversible ionic bonds at the 1-nm scale, a cross-linked polymer network at the 10-nm scale, and bicontinuous hard/soft phase networks at the 100-nm scale. We find that the polymer network at the 10-nm scale determines the threshold of energy release rate G 0 above which the crack grows, while the bicontinuous phase networks at the 100-nm scale significantly decelerate the crack advance until a transition G tran far above G 0 In situ small-angle X-ray scattering analysis reveals that the hard phase network suppresses the crack advance to show decelerated fatigue fracture, and G tran corresponds to the rupture of the hard phase network., 11782740
• Non-Linear Rheological Study of Hydrogel Sliding Friction in Water and Concentrated Hyaluronan Solution
  Satoshi Hirayama; Takayuki Kurokawa; Jian Ping Gong
  Tribology International, 147, 106270, Feb. 2020, [Peer-reviewed], [Last author], [International Magazine]
  English, Scientific journal, 11782740;11782741
• Mechanical Behavior of Unidirectional Fiber Reinforced Soft Composites
  Chung-Yuen Hui; Zezhou Liu; Stuart Leigh Phoenix; Daniel R. King; Wei Cui; Yiwan Huang; Jian Ping Gong
  Extreme Mechanics Letters, 35, 100642, Feb. 2020, [Peer-reviewed], [Last author], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal, 11782740
• Effect of Relative Strength of Two Networks on the Internal Fracture Process of Double Network Hydrogels As Revealed by in Situ Small-Angle X-ray Scattering
  Kazuki Fukao; Tasuku Nakajima; Takayuki Nonoyama; Takayuki Kurokawa; Takahiko Kawai; Jian Ping Gong
  Macromolecules, 53, 4, 1154, 1163, 31 Jan. 2020, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, 11782740;24510616
• Effect of void structure on the toughness of double network hydrogels
  Tasuku Nakajima; Hidemitsu Furukawa; Yoshimi Tanaka; Takayuki Kurokawa; Jian Ping Gong
  Soft Matter, 16, 37, 8618, 8627, Wiley, 2020
  Scientific journal
• Relaxation Dynamics and Underlying Mechanism of a Thermally Reversible Gel from Symmetric Triblock Copolymer
  Ya Nan Ye; Kunpeng Cui; Tsutomu Indei; Tasuku Nakajima; Dominique Hourdet; Takayuki Kurokawa; Jian Ping Gong
  Macromolecules, 52, 22, 8651, 8661, American Chemical Society ({ACS}), 26 Nov. 2019, [Peer-reviewed], [Last author, Corresponding author], ［Internationally co-authored］
  English, Scientific journal, 11782740
• Tough Double-Network Gels and Elastomers from the Nonprestretched First Network
  Tasuku Nakajima; Yuhei Ozaki; Ryo Namba; Kumi Ota; Yuki Maida; Takahiro Matsuda; Takayuki Kurokawa; Jian Ping Gong
  ACS Macro Letters, 8, 11, 1407, 1412, American Chemical Society ({ACS}), 19 Nov. 2019, [Peer-reviewed], [Last author], [International Magazine]
  English, Scientific journal, 11782740
• Instant Thermal Switching from Soft Hydrogel to Rigid Plastics Inspired by Thermophile Proteins
  Takayuki Nonoyama; Yong Woo Lee; Kumi Ota; Keigo Fujioka; Wei Hong; Jian Ping Gong
  Advanced Materials, 32, 4, 1905878, Nov. 2019, [Peer-reviewed], [Last author, Corresponding author], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal, 11782741;11782740
• Adjacent cationic-aromatic sequences yield strong electrostatic adhesion of hydrogels in seawater
  Hailong Fan; Jiahui Wang; Zhen Tao; Junchao Huang; Ping Rao; Takayuki Kurokawa; Jian Ping Gong
  NATURE COMMUNICATIONS, 10, 5127, Nov. 2019, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, 11782740
• Fabrication of Tough Hydrogel Composites from Photoresponsive Polymers to Show Double-Network Effect
  Zhen Tao; Hailong Fan; Junchao Huang; Taolin Sun; Takayuki Kurokawa; Jian Ping Gong
  ACS APPLIED MATERIALS & INTERFACES, 11, 40, 37139, 37146, Oct. 2019, [Peer-reviewed], [Last author, Corresponding author], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal, 11782740
• Toughening Mechanism of Double Network Gels and New Research Trends
  Ryuji Kiyama; Jian Ping Gong
  Journal of Society of Rubber Science and Technology, Japan, 92, 9, 352, 356, Sep. 2019, [Invited], [Last author]
  Japanese, Scientific journal
• Effect of Structure Heterogeneity on Mechanical Performance of Physical Polyampholytes Hydrogels
  Kunpeng Cui; Ya Nan Ye; Tao Lin Sun; Liang Chen; Xueyu Li; Takayuki Kurokawa; Tasuku Nakajima; Takayuki Nonoyama; Jian Ping Gong
  Macromolecules, 52, 19, 7369, 7378, Sep. 2019, [Peer-reviewed], [Corresponding author], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal, 11782740
• Programmed Diffusion Induces Anisotropic Superstructure in Hydrogel with High Mechano-Optical Sensitivity
  Laicong Qiao; Cong Du; Jian Ping Gong; Zi Liang Wu; Qiang Zhen
  Advanced Materials Technologies, 4, 11, 1900665, Sep. 2019, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal, 11782740
• Internal Damage Evolution in Double-Network Hydrogels Studied by Microelectrode Technique
  Honglei Guo; Wei Hong; Takayuki Kurokawa; Takahiro Matsuda; Zi Liang Wu; Tasuku Nakajima; Masakazu Takahata; Taolin Sun; Ping Rao; Jian Ping Gong
  Macromoledules, 52, 18, 7114, 7122, Sep. 2019, [Peer-reviewed], [Last author, Corresponding author], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal, 11782741;11782740
• Macroscale Double Networks: Design Criteria for Optimizing Strength and Toughness
  Daniel R. King; Tsuyoshi Okumura; Riku Takahashi; Takayuki Kurokawa; Jian Ping Gong
  ACS Applied Materials & Interfaces, 11, 38, 35343, 35353, Sep. 2019, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, The double network concept, based on the fracture of sacrificial bonds, has been revolutionary toward the creation of robust soft materials. Based on the essence of double network hydrogels, macroscale, three-dimensional printed rigid sacrificial networks are embedded within silicone rubber stretchable matrices. Preferential fracture of the sacrificial network results in a ∼60 time increase in stiffness and a ∼50% increase in the work of extension compared with the neat matrix. Maximizing yield strength while maintaining multistep internal fracture occurs when the strength of the sacrificial network approaches the strength of the matrix. Upon determining the optimal sacrificial network strength, the sacrificial bond section density can be increased to maximize energy dissipation and toughening efficiencies up to ∼70% of the maximum theoretical toughness are achieved. High toughness and dissipation are achieved because topological interlocking enables significant force transmission to the sacrificial network at smaller length scales than interfacial adhesion, allowing much higher sacrificial bond density. This method is general and can be used with a variety of materials systems, without requiring strong interfacial adhesion, contrasting traditional composite systems. Demonstrating that the double network concept can be used at length scales far beyond the molecular scale will have important implications toward the development of future structural materials., 11782740
• 鍛えて成長するゲル―破壊による創造の材料科学―
  Takahiro Matsuda; Tasuku Nakajima; Jian Ping Gong
  現代化学, 581, 53, 57, Aug. 2019, [Invited], [Last author]
  Japanese, Scientific journal
• Modulation and Characterization of the Double Network Hydrogel Surface-bulk Transition
  Martin Frauenlob; Daniel R. King; Honglei Guo; Seiichiro Ishihara; Masumi Tsuda; Takayuki Kurokawa; Hisashi Haga; Shinya Tanaka; Jian Ping Gong
  Macromolecules, 52, 17, 6704, 6713, Aug. 2019, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, 11782740
• Hydrogel/Elastomer Laminates Bonded via Fabric Interphases for Stimuli-Responsive Actuators
  Amber M. Hubbard; Wei Cui; Yiwan Huang; Riku Takahashi; Michael D. Dickey; Jan Genzer; Daniel R. King; Jian Ping Gong
  Matter, 1, 3, 674, 689, Aug. 2019, [Peer-reviewed], [Last author], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal, 11782740
• Polyelectrolyte Complexation via Viscoelastic Phase Separation Results in Tough and Self-Recovering Porous Hydrogel
  Kohei Murakawa; Daniel R. King; Tao Lin Sun; Honglei Guo; Takayuki Kurokawa; Jian Ping Gong
  Journal of Materials Chemistry B, 7, 35, 5296, 5305, Aug. 2019, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, Polyelectrolyte complexation between oppositely charged polyelectrolytes forms coacervates in dilute solutions and thin films in concentrated solutions. It is difficult to obtain macroscopically uniform bulk polyelectrolyte complex (PEC) materials, since the two polymers form insoluble complexes quickly at the contact interface during mixing, resulting in heterogeneous aggregates. Here, we succeeded in preparing bulk PEC materials based on desalting-induced polyelectrolyte complexation via viscoelastic phase separation. With a high ionic strength aqueous medium, a homogeneous and concentrated solution containing oppositely charged polyelectrolytes is prepared. Desalting of the counter-ions and co-ions of the solution through semi-permeable membranes induces viscoelastic phase separation of the solution to form a physical hydrogel with open pore structure. Regulating the charge ratio of the two oppositely charged polymers results in significant changes in the porous morphology and mechanical properties. The charge-balanced PEC hydrogels show unique properties including high toughness and self-recovery due to the reversible ionic associations. The porous yet tough properties of bulk PEC hydrogels makes them potential candidates for applications such as cell scaffolds., 11782741;11782740
• A Multi-axial Theory of Double Network Hydrogels
  Vu Ngoc Khiêm; Thanh-Tam Mai; Kenji Urayama; Jian Ping Gong; Mikhail Itskov
  Macromolecules, 52, 15, 5937, 5947, Jul. 2019, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal
• Tough Double Network Elastomers Reinforced by the Amorphous Cellulose Network
  Joji Murai; Tasuku Nakajima; Takahiro Matsuda; Katsuhiko Tsunoda; Takayuki Nonoyama; Takayuki Kurokawa; Jian Ping Gong
  Polymer, 178, 121686, Jul. 2019, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, 11782740;24510616
• Double Network Hydrogels Based on Semi-rigid Polyelectrolyte Physical Networks
  Riku Takahashi; Takuma Ikai; Takayuki Kurokawa; Daniel R. King; Jian Ping Gong
  Journal of Materials Chemistry B, 7, 41, 6347, 6354, Jul. 2019, [Peer-reviewed], [Invited], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, Applying the double network principle to develop tough hydrogels with different polymer chemistries is important for the potential application of hydrogel materials. Synthesis of the two interpenetrated networks with contrasting structure and properties required for double networks usually involves a two-step polymerization process. In this work, we present a new method to synthesize tough double network hydrogels by post-physical crosslinking of linear semi-rigid polyelectrolytes entrapped in a chemically crosslinked neutral network. Owing to their semi-rigid structure, the linear polyelectrolytes form a brittle physical network above their overlap concentration in multi-valent ZrCl2O ion solutions without macroscopic phase separation within the flexible neutral network. The double network hydrogels thus prepared exhibit high modulus (∼1.7 MPa), strength (∼1.3 MPa), fracture strain (∼7.3), and strain energy density (∼5.9 MJ m-3), while containing over 80% water. These materials also exhibit modest self-healing ability (∼51% after 30 minutes), demonstrating an additional benefit of a physical sacrificial network. This method is simpler than the conventional two-step polymerization and could be applied to develop tough hydrogels from rigid polyelectrolytes, including biopolymers such as DNA, HA, and chondroitin sulfate., 11782740;24510616
• Facile Synthesis of Novel Elastomers with Tunable Dynamics for Toughness, Self-healing and Adhesion
  Liang Chen; Tao Lin Sun; Kunpeng Cui; Daniel R. King; Takayuki Kurokawa; Yoshiyuki Saruwatari; Jian Ping Gong
  Journal of Materials Chemistry A, 7, 29, 17334, 17344, Jun. 2019, [Peer-reviewed], [Last author, Corresponding author]
  English, Scientific journal, 11782741;11782740;24510616
• Hydrophobic Hydrogels with Fruit-like Structure and Functions
  Hui Guo; Tasuku Nakajima; Dominique Hourdet; Alba Marcellan; Costantino Creton; Wei Hong; Takayuki Kurokawa; Jian Ping Gong
  Advanced Materials, 31, 25, 1900702, May 2019, [Peer-reviewed], [Last author, Corresponding author], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal, Normally, a polymer network swells in a good solvent to form a gel but the gel shrinks in a poor solvent. Here, an abnormal phenomenon is reported: some hydrophobic gels significantly swell in water, reaching water content as high as 99.6 wt%. Such abnormal swelling behaviors in the nonsolvent water are observed universally for various hydrophobic organogels containing omniphilic organic solvents that have a higher affinity to water than to the hydrophobic polymers. The formation of a semipermeable skin layer due to rapid phase separation, and the asymmetric diffusion of water molecules into the gel driven by the high osmotic pressure of the organic solvent-water mixing, are found to be the reasons. As a result, the hydrophobic hydrogels have a fruit-like structure, consisting of hydrophobic skin and water-trapped micropores, to display various unique properties, such as significantly enhanced strength, surface hydrophobicity, and antidrying, despite their extremely high water content. Furthermore, the hydrophobic hydrogels exhibit selective water absorption from concentrated saline solutions and rapid water release at a small pressure like squeezing juices from fruits. These novel functions of hydrophobic hydrogels will find promising applications, e.g., as materials that can automatically take the fresh water from seawater., 11782741;11782740
• バイオマテリアルによる肝癌幹細胞の新規誘導法
  谷 道夫; 津田 真寿美; 鈴鹿 淳; 王 磊; 杉野 弘和; 谷川 聖; 石田 雄介; グン 剣萍; 田中 伸哉; 武冨 紹信
  日本外科学会定期学術集会抄録集, 119回, PS, 6, (一社)日本外科学会, Apr. 2019
  Japanese
• Fabrication of Tough and Stretchable Hybrid Double-Network Elastomers Using Ionic Dissociation of Polyelectrolyte in Nonaqueous Media
  Takahiro Matsuda; Tasuku Nakajima; Jian Ping Gong
  Chemistry of Materials, 31, 10, 3766, 3776, Apr. 2019, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, 11782740;24510616
• Superior Fracture Resistance of Fiber Reinforced Polyampholyte Hydrogels Achieved by Extraordinarily Large Energy-dissipative Process Zones
  Yiwan Huang; Daniel R. King; Wei Cui; Tao Lin Sun; Honglei Guo; Takayuki Kurokawa; Hugh R. Brown; Chung-Yuen Hui; Jian Ping Gong
  Journal of Materials Chemistry A, 7, 22, 13431, 13440, Apr. 2019, [Peer-reviewed], [Last author, Corresponding author], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal, 11782741;11782740;24510616
• Damage Cross-effect and Anisotropy in Tough Double Network Hydrogels Revealed by Biaxial Stretching
  Thanh-Tam Mai; Takahiro Matsuda; Tasuku Nakajima; Jian Ping Gong; Kenji Urayama
  Soft Matter, 15, 18, 3719, 3732, Apr. 2019, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, 24510616
• Tough and Self-healing Supramolecular Hydrogels Composed of Polyampholytes
  Kunpeng Cui; Tao Lin Sun; Jian Ping Gong
  Polymer Bulletin, 3, 1, 6, Mar. 2019, [Invited], [Last author]
  Chinese, Scientific journal
• Mechanoresponsive Self-growing Hydrogels Inspired by Muscle Training
  Takahiro Matsuda; Runa Kawakami; Ryo Namba; Tasuku Nakajima; Jian Ping Gong
  Science, 363, 6426, 504, 508, Feb. 2019, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, 11782740
• Osteochondral Autograft Transplantation Technique Augmented by an Ultrapurified Alginate Gel Enhances Osteochondral Repair in a Rabbit Model.
  Ryosuke Hishimura; Tomohiro Onodera; Kazutoshi Hontani; Rikiya Baba; Kentaro Homan; Shinji Matsubara; Zenta Joutoku; WooYoung Kim; Takayuki Nonoyama; Takayuki Kurokawa; Jian Ping Gong; Norimasa Iwasaki
  The American journal of sports medicine, 47, 2, 468, 478, Feb. 2019, [Peer-reviewed], [International Magazine]
  English, Scientific journal, BACKGROUND: One of the most important limitations of osteochondral autograft transplantation (OAT) is the adverse effect on donor sites in the knee. To decrease the number and/or size of osteochondral defects, we devised a method with biomaterial implantation after OAT. HYPOTHESIS: OAT augmented by ultrapurified alginate (UPAL) gel enhances cartilage repair capacity. STUDY DESIGN: Controlled laboratory study. METHODS: Seventy-five osteochondral defects in rabbits were divided into 3 groups: osteochondral defects with OAT alone, defects with OAT augmented by UPAL gel (combined group), and defects without intervention as controls. Macroscopic and histological evaluations of the reparative tissues were performed at 4 and 12 weeks postoperatively. Histological evaluation of graft cartilage degradation was also performed. To evaluate the effects of UPAL gel on graft healing, repaired bone volumes and osseointegration of the graft were evaluated. Collagen orientation and the mechanical properties of the reparative tissue and graft cartilage were also evaluated qualitatively. RESULTS: The macroscopic and histological evaluations of the combined group were significantly superior to the other groups at 12 weeks postoperatively. Regarding degenerative change of the graft, the histological scores of the combined group were significantly higher than those of the OAT-alone group. The values of repaired subchondral bone volumes and osseointegration of the graft were almost identical in both groups. Collagen orientation and the mechanical properties of the reparative tissue and graft cartilage were significantly better in the combined group than in the other groups. CONCLUSION: Administration of UPAL gel in OAT enhanced cartilage repair and protected graft cartilage without inhibiting subchondral bone repair and graft survival. CLINICAL RELEVANCE: OAT augmented by UPAL gel decreases the number and/or size of osteochondral grafts, minimizing the risk of donor site morbidity. This combination technique has the potential to improve clinical outcomes and expand the surgical indications for OAT.
• Shearing-induced Contact Pattern Formation in Hydrogels Sliding in Polymer Solution
  Shintaro Yashima; Satoshi Hirayama; Takayuki Kurokawa; Thomas Salez; Haruna Takefuji; Wei Hong; Jian Ping Gong
  Soft Matter, 15, 9, 1953, 1959, Jan. 2019, [Peer-reviewed], [Last author, Corresponding author], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal, The contact of a hydrogel during the rotational shearing on a glass surface in concentrated polymer solution was observed in situ. Dynamic contact patterns that rotate in-phase with the rotational shearing of the gel were observed for the first time. The contact patterns with a periodicity in the circumferential direction appeared and became fine with the shearing time. The patterns appeared more quickly at an elevated sliding velocity, polymer concentration, and normal pressure. Furthermore, the softness of the gel also substantially influenced the characteristics of the patterns. The pattern formation was discussed in terms of the non-linear rheology of the polymer solution at the rotational soft interface., 11782740;11782741
• Network elasticity of a model hydrogel as a function of swelling ratio: from shrinking to extreme swelling states
  Ken-ichi Hoshino; Tasuku Nakajima; Takahiro Matsuda; Takamasa Sakai; Jian Ping Gong
  SOFT MATTER, 14, 47, 9693, 9701, Dec. 2018, [Peer-reviewed], [Last author], [International Magazine]
  English, Scientific journal, 11782740
• 刺激応答性発色ゲル
  堀端修人; 中島 祐; 龔 剣萍
  応用物理学会・有機分子・バイオエレクトロニクス分科会 会誌, 29, 4, 232, 235, Nov. 2018, [Invited]
  Japanese, Scientific journal
• Multiscale Energy Dissipation Mechanism in Tough and Self-Healing Hydrogels
  Kunpeng Cui; Tao Lin Sun; Xiaobin Liang; Ken Nakajima; Ya Nan Ye; Liang Chen; Takayuki Kurokawa; Jian Ping Gong
  Physical Review Letters, 121, 18, 185501, Oct. 2018, [Peer-reviewed], [Corresponding author], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal, 11782740
• Micro Patterning of Hydroxyapatite by Soft Lithography on Hydrogels for Selective Osteoconduction
  Ryuji Kiyama; Takayuki Nonoyama; Susumu Wada; Shingo Semba; Nobuto Kitamura; Tasuku Nakajima; Takayuki Kurokawa; Kazunori Yasuda; Shinya Tanaka; Jian Ping Gong
  Acta Biomaterialia, 81, 60, 69, Oct. 2018, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, Mechanically robust hydrogels are promising biomaterials as artificial supportive tissue. These applications require selective and robust bonding of the hydrogels to living tissue. Recently, we achieved strong in vivo bone bonding of a tough double network (DN) hydrogel, a potential material for use as artificial cartilage and tendon, by hybridizing osteoconductive hydroxyapatite (HAp) in the gel surface layer. In this work, we report micro patterning of HAp at the surface of the DN hydrogel for selective osteoconduction. Utilizing the dissolution of HAp in an acidic environment, the soft lithography technique using an acid gel stamp was adopted to form a high-resolution HAp pattern on the gel. The HAp-patterned gel showed well-regulated migration and adhesion of cells in vitro. Moreover, the HAp-patterned gel showed selective and robust bonding to the rabbit bone tissue in vivo. This HAp soft lithography technique allows for simple and quick preparation of tailor-made osteoconductive hydrogels and can be applied to other hydrogels for selective bone bonding. STATEMENT OF SIGNIFICANCE: Hydrogels, preserving large amount of water, have been studied for next-generation artificial soft tissues. However, fixation of hydrogels to living tissue was unsolved issue for clinical application. Recently, we achieved robust bonding of a tough double network gel to bone in vivo by coating of osteoconductive hydroxyapatite in the gel surface layer. For further progress for practical use, we report the micro patterning of HAp at the surface of the DN hydrogel by using soft lithography technique, to perform selective bonding to only objective area without unnecessary coalescence. The HAp lithography technique is simple, quick and non-toxic method to prepare tailor-made osteoconductive hydrogels and has universality of species of hydrogels., 42864761
• Tough Particle-Based Double Network Hydrogels for Functional Solid Surface Coatings
  Riku Takahashi; Kouichi Shimano; Haruka Okazaki; Takayuki Kurokawa; Tasuku Nakajima; Takayuki Nonoyama; Daniel R. King; Jian Ping Gong
  Advanced Materials Interface, 5, 23, 1801018, Oct. 2018, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, 11782740
• Elastic-Plastic Transformation of Polyelectrolyte Complex Hydrogels from Chitosan and Sodium Hyaluronate
  Ran Shi; Tao Lin Sun; Feng Luo; Tasuku Nakajima; Takayuki Kurokawa; Yue Zhen Bin; Michael Rubinstein; Jian Ping Gong
  Macromolecules, 51, 21, 8887, 8898, Oct. 2018, [Peer-reviewed], [Last author, Corresponding author], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal, Hydrogels formed by polyelectrolyte complexation (PEC) of oppositely charged biopolymers, free of any chemical additives, are promising biomaterials. In this work, the mechanical behavior of hydrogels consisting of positively charged chitosan and negatively charged sodium hyaluronate (HA) at balanced charge composition is investigated. These hydrogels exhibit strong tensile strain and strain rate dependence. They are elastic-like, independent of the strain rate at small strain, but exhibit plastic-like behavior above the yield point by showing a monotonous decrease of the stress. The cyclic tensile test demonstrates that these hydrogels exhibit small and quickly recoverable hysteresis in the elastic-like region, but large and partially recoverable hysteresis above the yield point. The stress relaxation experiment shows a plateau in the reduced stress followed by an abrupt fracture, and the time-to-failure decreases exponentially with increasing applied step-strain. Such elastic-to-plastic-like transformation of the biopolymer PEC gels is quite different from the behaviors of PEC hydrogels formed by oppositely charged vinyl-type synthetic polyelectrolytes due to the difference in flexibility, charge density, and ionic bond strength of these polymers., 44551380
• How Supertough Gels Break
  Itamar Kolvin; John M. Kolinski; Jian Ping Gong; Jay Fineberg
  Physical Review Letters, 121, 13, 135501, Sep. 2018, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal
• Distinctive Characteristics of Internal Fracture in Tough Double Network Hydrogels Revealed by Various Modes of Stretching
  Thanh-Tam Mai; Takahiro Matsuda; Tasuku Nakajima; Jian Ping Gong; Kenji Urayama
  Macromolecules, 51, 14, 5245, 5257, Jul. 2018, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal
• Tough Hydrogels with Fast, Strong, and Reversible Underwater Adhesion Based on a Multi-Scale Design
  Ping Rao; Tao Lin Sun; Liang Chen; Riku Takahashi; Gento Shinohara; Hui Guo; Daniel R. King; Takayuki Kurokawa; Jian Ping Gong
  Advanced Materials, 30, 32, 1801884, Jun. 2018, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, Hydrogels have promising applications in diverse areas, especially wet environments including tissue engineering, wound dressing, biomedical devices, and underwater soft robotics. Despite strong demands in such applications and great progress in irreversible bonding of robust hydrogels to diverse synthetic and biological surfaces, tough hydrogels with fast, strong, and reversible underwater adhesion are still not available. Herein, a strategy to develop hydrogels demonstrating such characteristics by combining macroscale surface engineering and nanoscale dynamic bonds is proposed. Based on this strategy, excellent underwater adhesion performance of tough hydrogels with dynamic ionic and hydrogen bonds, on diverse substrates, including hard glasses, soft hydrogels, and biological tissues is obtained. The proposed strategy can be generalized to develop other soft materials with underwater adhesion., 11782740
• Tough and Self-Recoverable Thin Hydrogel Membranes for Biological Applications
  Ya Nan Ye; Martin Frauenlob; Lei Wang; Masumi Tsuda; Tao Lin Sun; Kunpeng Cui; Riku Takahashi; Huijie Zhang; Tasuku Nakajima; Takayuki Nonoyama; Takayuki Kurokawa; Shinya Tanaka; Jian Ping Gong
  Advanced Functional Materials, 28, 31, 1801489, Jun. 2018, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, 11782740
• 高強度・高靭性ダブルネットワークゲルの開発とソフト人工軟骨への応用
  野々山貴行; 龔 剣萍; 安田和則
  機能材料, 38, 5, 51, 59, May 2018, [Invited]
  Japanese, Scientific journal
• Creating Stiff, Tough, and Functional Hydrogel Composites with Low-Melting-Point Alloys
  Riku Takahashi; Tao Lin Sun; Yoshiyuki Saruwatari; Takayuki Kurokawa; Daniel R. King; Jian Ping Gong
  Advanced Materials, 30, 16, 1706885, Wiley-VCH Verlag, 19 Apr. 2018, [Peer-reviewed], [Corresponding author], [International Magazine]
  English, Scientific journal, 11782740
• 新規技術を用いた新しい研究アプローチ 高分子ハイドロゲルによる癌幹細胞へのリプログラミング誘導技術
  津田 真寿美; 鈴鹿 淳; 王 磊; 仙葉 慎吾; 油谷 幸代; 黒川 孝幸; 近江谷 克裕; 安田 和則; グン 剣萍; 田中 伸哉
  日本病理学会会誌, 107, 1, 217, 217, (一社)日本病理学会, Apr. 2018
  Japanese
• Fracture Process of Double-Network Gels by Coarse-Grained Molecular Dynamics Simulation
  Yuji Higuchi; Keisuke Saito; Takamasa Sakai; Jian Ping Gong; Momoji Kubo
  MACROMOLECULES, 51, 8, 3075, 3087, Apr. 2018, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• A Facile Method to Fabricate Anisotropic Hydrogels with Perfectly Aligned Hierarchical Fibrous Structures
  Md. Tariful Islam Mredha; Yun Zhou Guo; Takayuki Nonoyama; Tasuku Nakajima; Takayuki Kurokawa; Jian Ping Gong
  Advanced Materials, 30, 9, 1704937, 1704937, Wiley, Mar. 2018, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, 11782740
• Tough and variable-band-gap photonic hydrogel displaying programmable angle-dependent colors
  Md. Anamul Haque; Kei Mito; Takayuki Kurokawa; Tasuku Nakajima; Takayuki Nonoyama; Muhammad Ilyas; Jian Ping Gong
  ACS Omega, 3, 1, 55, 62, American Chemical Society, Jan. 2018, [Peer-reviewed], [Last author, Corresponding author], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal, 11782740;11782741
• Anisotropic Growth of Hydroxyapatite in Stretched Double Network Hydrogel
  Kazuki Fukao; Takayuki Nonoyama; Ryuji Kiyama; Kazuya Furusawa; Takayuki Kurokawa; Tasuku Nakajima; Jian Ping Gong
  ACS Nano, 11, 12, 12103, 12110, American Chemical Society, 26 Dec. 2017, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, 11782740
• Inorganic/Organic Double-Network Gels Containing Ionic Liquids
  Eiji Kamio; Tomoki Yasui; Yu Iida; Jian Ping Gong; Hideto Matsuyama
  ADVANCED MATERIALS, 29, 47, 1704118, Dec. 2017, [Peer-reviewed], [International Magazine]
  English, Scientific journal, 11782740
• ダブルネットワークゲル（ DN ゲル）の軟骨応用に向けた検討
  野々山貴行; 中島祐; 黒川孝幸; 北村信人; 安田和則; 龔剣萍
  FC Report, 35, 4, 148, 152, Oct. 2017
  Japanese, Scientific journal
• Water-Triggered Ductile-Brittle Transition of Anisotropic Lamellar Hydrogels and Effect of Confinement on Polymer Dynamics
  Muhammad Ilyas; Md. Anamul Haque; Youfeng Yue; Takayuki Kurokawa; Tasuku Nakajima; Takayuki Nonoyama; Jian Ping Gong
  MACROMOLECULES, 50, 20, 8169, 8177, Oct. 2017, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, 11782741;11782740
• Supramolecular hydrogels with multi-cylindrical lamellar bilayers: Swelling-induced contraction and anisotropic molecular diffusion
  Kei Mito; Md. Anamul Haque; Tasuku Nakajima; Maki Uchiumi; Takayuki Kurokawa; Takayuki Nonoyama; Jian Ping Gong
  POLYMER, 128, 373, 378, Oct. 2017, [Peer-reviewed], [Invited], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, 11782740
• Tough, self-recovery and self-healing polyampholyte hydrogels
  Tao Lin Sun; Kunpeng Cui; Jian Ping Gong
  POLYMER SCIENCE SERIES C, 59, 1, 11, 17, Sep. 2017, [Peer-reviewed], [Invited], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal
• Anisotropic tough double network hydrogel from fish collagen and its spontaneous in vivo bonding to bone
  Md. Tariful Islam Mredha; Nobuto Kitamura; Takayuki Nonoyama; Susumu Wada; Keiko Goto; Xi Zhang; Tasuku Nakajima; Takayuki Kurokawa; Yasuaki Takagi; Kazunori Yasuda; Jian Ping Gong
  BIOMATERIALS, 132, 85, 95, Jul. 2017, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, 11782740
• Effects of osteochondral defect size on cartilage regeneration using a double-network hydrogel
  Kotaro Higa; Nobuto Kitamura; Keiko Goto; Takayuki Kurokawa; Jian Ping Gong; Fuminori Kanaya; Kazunori Yasuda
  BMC MUSCULOSKELETAL DISORDERS, 18, 210, May 2017, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Tough polyion-complex hydrogels from soft to stiff controlled by monomer structure
  Feng Luo; Tao Lin Sun; Tasuku Nakajima; Takayuki Kurokawa; Xufeng Li; Honglei Guo; Yiwan Huang; Huijie Zhang; Jian Ping Gong
  POLYMER, 116, 487, 497, May 2017, [Peer-reviewed], [Invited], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal
• Bulk Energy Dissipation Mechanism for the Fracture of Tough and Self-Healing Hydrogels
  Tao Lin Sun; Feng Luo; Wei Hong; Kunpeng Cui; Yiwan Huang; Hui Jie Zhang; Daniel R. King; Takayuki Kurokawa; Tasuku Nakajima; Jian Ping Gong
  MACROMOLECULES, 50, 7, 2923, 2931, Apr. 2017, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, 11782740
• Energy-Dissipative Matrices Enable Synergistic Toughening in Fiber Reinforced Soft Composites
  Yiwan Huang; Daniel R. King; Tao Lin Sun; Takayuki Nonoyama; Takayuki Kurokawa; Tasuku Nakajima; Jian Ping Gong
  ADVANCED FUNCTIONAL MATERIALS, 27, 9, 1605350, Mar. 2017, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, 11782740
• Stimuli-Responsive Transformation of a Gradient Gel
  Tasuku Nakajima; Kenta Hiwatashi; Jian Hu; Takayuki Kurokawa; Jian Ping Gong
  KOBUNSHI RONBUNSHU, 74, 4, 311, 318, 2017, [Peer-reviewed], [Invited]
  Japanese, Scientific journal
• 刺激応答性構造色と異方的物性を示すリオトロピック液晶ゲル
  中島祐; 龔剣萍
  液晶, 20, 4, 212, 217, Oct. 2016, [Peer-reviewed], [Invited]
  Japanese, Scientific journal
• Hydroxyapatite-coated double network hydrogel directly bondable to the bone: Biological and biomechanical evaluations of the bonding property in an osteochondral defect
  Susumu Wada; Nobuto Kitamura; Takayuki Nonoyama; Ryuji Kiyama; Takayuki Kurokawa; Jian Ping Gong; Kazunori Yasuda
  ACTA BIOMATERIALIA, 44, 125, 134, Oct. 2016, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Sensing surface mechanical deformation using active probes driven by motor proteins
  Daisuke Inoue; Takahiro Nitta; Arif Md. Rashedul Kabir; Kazuki Sada; Jian Ping Gong; Akihiko Konagaya; Akira Kakugo
  NATURE COMMUNICATIONS, 7, 12557, Oct. 2016, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Fundamental biomaterial properties of tough glycosaminoglycan-containing double network hydrogels newly developed using the molecular stent method
  Kotaro Higa; Nobuto Kitamura; Takayuki Kurokawa; Keiko Goto; Susumu Wada; Takayuki Nonoyama; Fuminori Kanaya; Kazuyuki Sugahara; Jian Ping Gong; Kazunori Yasuda
  ACTA BIOMATERIALIA, 43, 38, 49, Oct. 2016, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Stretching-induced ion complexation in physical polyampholyte hydrogels
  Kunpeng Cui; Tao Lin Sun; Takayuki Kurokawa; Tasuku Nakajima; Takayuki Nonoyama; Liang Chen; Jian Ping Gong
  SOFT MATTER, 12, 43, 8833, 8840, Sep. 2016, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, 44551380
• In vivo cartilage regeneration induced by a double-network hydrogel: Evaluation of a novel therapeutic strategy for femoral articular cartilage defects in a sheep model
  Nobuto Kitamura; Masashi Yokota; Takayuki Kurokawa; Jian Ping Gong; Kazunori Yasuda
  JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 104, 9, 2159, 2165, Sep. 2016, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• ハイドロキシアパタイト複合化PAMPS/PDMAAmダブルネットワークゲル人工軟骨の関節内におけるin vivo骨接着性評価
  和田 進; 北村 信人; 野々山 貴行; 木山 竜二; 仙葉 愼吾; 小野寺 純; 横田 正司; 後藤 佳子; 比嘉 浩太郎; 黒川 孝幸; Gong Jian Ping; 安田 和則
  日本整形外科学会雑誌, 90, 8, S1598, S1598, (公社)日本整形外科学会, Aug. 2016
  Japanese
• Creep Behavior and Delayed Fracture of Tough Polyampholyte Hydrogels by Tensile Test
  Sadia Nazneen Karobi; Tao Lin Sun; Takayuki Kurokawa; Feng Luo; Tasuku Nakajima; Takayuki Nonoyama; Jian Ping Gong
  MACROMOLECULES, 49, 15, 5630, 5636, Aug. 2016, [Peer-reviewed], [Last author], [International Magazine]
  English, Scientific journal
• Double-Network Hydrogels Strongly Bondable to Bones by Spontaneous Osteogenesis Penetration
  Takayuki Nonoyama; Susumu Wada; Ryuji Kiyama; Nobuto Kitamura; Md. Tariful Islam Mredha; Xi Zhang; Takayuki Kurokawa; Tasuku Nakajima; Yasuaki Takagi; Kazunori Yasuda; Jian Ping Gong
  ADVANCED MATERIALS, 28, 31, 6740, 6745, Aug. 2016, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, 44551380
• Molecular Structure and Properties of Click Hydrogels with Controlled Dangling End Defect
  Ao-kai Zhang; Jun Ling; Kewen Li; Guo-dong Fu; Tasuku Nakajima; Takayuki Nonoyama; Takayuki Kurokawa; Jian Ping Gong
  JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS, 54, 13, 1227, 1236, Jul. 2016, [Peer-reviewed], [Last author, Corresponding author], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal, 44551380
• Self-Healing Behaviors of Tough Polyampholyte Hydrogels
  Abu Bin Ihsan; Tao Lin Sun; Takayuki Kurokawa; Sadia Nazneen Karobi; Tasuku Nakajima; Takayuki Nonoyama; Chanchal Kumar Roy; Feng Luo; Jian Ping Gong
  MACROMOLECULES, 49, 11, 4245, 4252, Jun. 2016, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal
• Tough Physical Double-Network Hydrogels Based on Amphiphilic Triblock Copolymers
  Hui Jie Zhang; Tao Lin Sun; Ao Kai Zhang; Yumihiko Ikura; Tasuku Nakajima; Takayuki Nonoyama; Takayuki Kurokawa; Osamu Ito; Hiroyuki Ishitobi; Jian Ping Gong
  ADVANCED MATERIALS, 28, 24, 4884, 4890, Jun. 2016, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, 44551380
• Decoupling dual-stimuli responses in patterned lamellar hydrogels as photonic sensors
  Youfeng Yue; Xufeng Li; Takayuki Kurokawa; Md. Anamul Haque; Jian Ping Gong
  JOURNAL OF MATERIALS CHEMISTRY B, 4, 23, 4104, 4109, May 2016, [Peer-reviewed], [Last author, Corresponding author], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal, 44551380
• Tough bacterial nanocellulose hydrogels based on the double-network technique
  Anamul Haque; Takayuki Kurokawa; Jian Ping Gong
  Bacterial NanoCellulose: A Sophisticated Multifunctional Material, 73, 89, CRC Press, 19 Apr. 2016, [International Magazine]
  English, In book
• Coupled instabilities of surface crease and bulk bending during fast free swelling of hydrogels
  Riku Takahashi; Yumihiko Ikura; Daniel R. King; Takayuki Nonoyama; Tasuku Nakajima; Takayuki Kurokawa; Hirotoshi Kuroda; Yoshihiro Tonegawa; Jian Ping Gong
  SOFT MATTER, 12, 23, 5081, 5088, Apr. 2016, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, 44551380
• Quantitative Observation of Electric Potential Distribution of Brittle Polyelectrolyte Hydrogels Using Microelectrode Technique
  Honglei Guo; Takayuki Kurokawa; Masakazu Takahata; Wei Hong; Yoshinori Katsuyama; Feng Luo; Jamil Ahmed; Tasuku Nakajima; Takayuki Nonoyama; Jian Ping Gong
  MACROMOLECULES, 49, 8, 3100, 3108, Apr. 2016, [Peer-reviewed], [Last author, Corresponding author], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal, 44551380
• Strong and Tough Polyion-Complex Hydrogels from Oppositely Charged Polyelectrolytes: A Comparative Study with Polyampholyte Hydrogels
  Feng Luo; Tao Lin Sun; Tasuku Nakajima; Daniel R. King; Takayuki Kurokawa; Yu Zhao; Abu Bin Ihsan; Xufeng Li; Honglei Guo; Jian Ping Gong
  MACROMOLECULES, 49, 7, 2750, 2760, Apr. 2016, [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, 44551380
• Yielding Criteria of Double Network Hydrogels
  Takahiro Matsuda; Tasuku Nakajima; Yuki Fukuda; Wei Hong; Takamasa Sakai; Takayuki Kurokawa; Ung-il Chung; Jian Ping Gong
  MACROMOLECULES, 49, 5, 1865, 1872, Mar. 2016, [Peer-reviewed], [Last author, Corresponding author], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal, 44551380
• Synthetic PAMPS gel activates BMP/Smad signaling pathway in ATDC5 cells, which plays a significant role in the gel-induced chondrogenic differentiation
  Keiko Goto; Taichi Kimura; Nobuto Kitamura; Shingo Semba; Yoshihiro Ohmiya; Sachiyo Aburatani; Satoko Matsukura; Masumi Tsuda; Takayuki Kurokawa; Jian Ping Gong; Shinya Tanaka; Kazunori Yasuda
  JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 104, 3, 734, 746, Mar. 2016, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Structure Transition and Function Modification of a Hydrogel Based on Lamellar Bilayers
  Kei Mito; Tasuku Nakajima; Takayuki Nonoyama; Jian Ping Gong
  KOBUNSHI RONBUNSHU, 73, 2, 157, 165, 2016, [Peer-reviewed], [Invited]
  Japanese, Scientific journal
• Double-network hydrogel and its potential biomedical application: A review
  Takayuki Nonoyama; Jian Ping Gong
  PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE, 229, 12, 853, 863, Dec. 2015, [Peer-reviewed], [Invited], [Last author], [International Magazine]
  English, Scientific journal
• Self-Adjustable Adhesion of Polyampholyte Hydrogels
  Chanchal Kumar Roy; Hong Lei Guo; Tao Lin Sun; Abu Bin Ihsan; Takayuki Kurokawa; Masakazu Takahata; Takayuki Nonoyama; Tasuku Nakajima; Jian Ping Gong
  ADVANCED MATERIALS, 27, 45, 7344, +, Dec. 2015, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, 44551380
• Phase-Separation-Induced Anomalous Stiffening, Toughening, and Self-Healing of Polyacrylamide Gels
  Koshiro Sato; Tasuku Nakajima; Toshiyuki Hisamatsu; Takayuki Nonoyama; Takayuki Kurokawa; Jian Ping Gong
  ADVANCED MATERIALS, 27, 43, 6990, +, Nov. 2015, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, 44551380
• Extremely tough composites from fabric reinforced polyampholyte hydrogels
  Daniel R. King; Tao Lin Sun; Yiwan Huang; Takayuki Kurokawa; Takayuki Nonoyama; Alfred J. Crosby; Jian Ping Gong
  MATERIALS HORIZONS, 2, 6, 584, 591, Nov. 2015, [Peer-reviewed], [Last author, Corresponding author], ［Internationally co-authored］, [International Magazine]
  English, Scientific journal, 44551380
• Anisotropic Gelation Induced by Very Little Amount of Filamentous Actin
  Kazuhiro Shikinaka; Manami Misu; Hidemitsu Furukawa; Akira Kakugo; Jian Ping Gong
  MACROMOLECULAR CHEMISTRY AND PHYSICS, 216, 20, 2007, 2011, Oct. 2015, [Peer-reviewed], [Last author], [International Magazine]
  English, Scientific journal
• バイオミネラリゼーションにより複合化したハイドロキシアパタイトコーティングPAMPS/PDMAAmダブルネットワークゲルの骨接着性の評価
  和田 進; 北村 信人; 野々山 貴行; 木山 竜二; 仙葉 愼吾; 比嘉 浩太郎; 黒川 孝幸; Gong Jian Ping; 安田 和則
  日本整形外科学会雑誌, 89, 8, S1585, S1585, (公社)日本整形外科学会, Sep. 2015
  Japanese
• PAMPSゲルはATDC5細胞の軟骨分化においてBMP/Smadシグナル経路を活性化する
  後藤 佳子; 北村 信人; 木村 太一; 仙葉 愼吾; 黒川 孝幸; Gong Jian Ping; 田中 伸哉; 安田 和則
  日本整形外科学会雑誌, 89, 8, S1708, S1708, (公社)日本整形外科学会, Sep. 2015
  Japanese
• Free Reprocessability of Tough and Self-Healing Hydrogels Based on Polyion Complex
  Feng Luo; Tao Lin Sun; Tasuku Nakajima; Takayuki Kurokawa; Abu Bin Ihsan; Xufeng Li; Honglei Guo; Jian Ping Gong
  ACS MACRO LETTERS, 4, 9, 961, 964, Sep. 2015, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal
• 皮膚を規範とした革新的機能材料・ラメラ構造を有するハイドロゲルの構造色と強靭性
  黒川 孝幸; ムハンマド アナムル ハック; 龔 剣萍
  工業材料, 63, 8, 64, 68, 日刊工業出版プロダクション ; 1955-, Aug. 2015, [Invited]
  Japanese, Scientific journal
• Friction of Zwitterionic Hydrogel by Dynamic Polymer Adsorption
  Jamil Ahmed; Tetsurou Yamamoto; Honglei Guo; Takayuki Kurokawa; Takayuki Nonoyama; Tasuku Nakajima; Jian Ping Gong
  MACROMOLECULES, 48, 15, 5394, 5401, Aug. 2015, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal, 44551380
• Drag force on micron-sized objects with different surface morphologies in a flow with a small Reynolds number
  Arif Md Rashedul Kabir; Daisuke Inoue; Yuri Kishimoto; Jun-ichi Hotta; Keiji Sasaki; Noboru Kitamura; Jian Ping Gong; Hiroyuki Mayama; Akira Kakugo
  POLYMER JOURNAL, 47, 8, 564, 570, Aug. 2015, [Peer-reviewed], [International Magazine]
  English, Scientific journal
• Tunable one-dimensional photonic crystals from soft materials
  Youfeng Yue; Jian Ping Gong
  JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY C-PHOTOCHEMISTRY REVIEWS, 23, 45, 67, Jun. 2015, [Peer-reviewed], [Invited]
  English, Scientific journal
• 高強度ゲルをつくる
  中島祐; 龔剣萍
  高分子, 64, 6, 367, 369, May 2015, [Invited]
  Japanese, Scientific journal
• Oppositely Charged Polyelectrolytes Form Tough, Self-Healing, and Rebuildable Hydrogels
  Feng Luo; Tao Lin Sun; Tasuku Nakajima; Takayuki Kurokawa; Yu Zhao; Koshiro Sato; Abu Bin Ihsan; Xufeng Li; Honglei Guo; Jian Ping Gong
  ADVANCED MATERIALS, 27, 17, 2722, +, May 2015, [Peer-reviewed]
  English, Scientific journal
• Hydrogels as feeder-free scaffolds for long-term self-renewal of mouse induced pluripotent stem cells
  Jing Jing Yang; Jian Fang Liu; Takayuki Kurokawa; Kazuhiro Kitada; Jian Ping Gong
  JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 9, 4, 375, 388, Apr. 2015, [Peer-reviewed]
  English, Scientific journal
• Polymer Adsorbed Bilayer Membranes Form Self-Healing Hydrogels with Tunable Superstructure
  Xufeng Li; Takayuki Kurokawa; Riku Takahashi; Md. Anamul Haque; Youfeng Yue; Tasuku Nakajima; Jan Ping Gong
  MACROMOLECULES, 48, 7, 2277, 2282, Apr. 2015, [Peer-reviewed]
  English, Scientific journal
• 小さな力で多彩な色をだす構造色ゲル―新しいメカノクロミック材料の合成法とその応用
  Tasuku Nakajima; Jian Ping Gong
  化学, 70, 4, 32, 36, Mar. 2015, [Invited]
  Japanese, Scientific journal
• In Vitro Platelet Adhesion of PNaAMPS/PAAm and PNaAMPS/PDMAAm Double-Network Hydrogels
  Wen Jiang Zheng; Zhen Qi Liu; Feng Xu; Jie Gao; Yong Mei Chen; Jian Ping Gong; Yoshihito Osada
  MACROMOLECULAR CHEMISTRY AND PHYSICS, 216, 6, 641, 649, Mar. 2015, [Peer-reviewed]
  English, Scientific journal
• Molecular structure of self-healing polyampholyte hydrogels analyzed from tensile behaviors
  Tao Lin Sun; Feng Luo; Takayuki Kurokawa; Sadia Nazneen Karobi; Tasuku Nakajima; Jian Ping Gong
  SOFT MATTER, 11, 48, 9355, 9366, 2015, [Peer-reviewed]
  English, Scientific journal
• Swim bladder collagen forms hydrogel with macroscopic superstructure by diffusion induced fast gelation
  Md. Tariful Islam Mredha; Xi Zhang; Takayuki Nonoyama; Tasuku Nakajima; Takayuki Kurokawa; Yasuaki Takagid; Jian Ping Gong
  JOURNAL OF MATERIALS CHEMISTRY B, 3, 39, 7658, 7666, 2015, [Peer-reviewed]
  English, Scientific journal
• Quasi-unidirectional shrinkage of gels with well-oriented lipid bilayers upon uniaxial stretching
  Tasuku Nakajima; Corentin Durand; Xu Feng Li; Md. Anamul Haque; Takayuki Kurokawa; Jian Ping Gong
  SOFT MATTER, 11, 2, 237, 240, 2015, [Peer-reviewed]
  English, Scientific journal
• Solvent and Ca2+ triggered robust and fast stress generation by ultrathin triple-network hydrogels
  Songmiao Liang; Jian Hu; Zi Liang Wu; Takayuki Kurokawa; Jian Ping Gong
  Extreme Mechanics Letters, 1, 17, 22, Elsevier Ltd, 01 Dec. 2014, [Peer-reviewed]
  English, Scientific journal
• In Situ Observation of Ca2+ Diffusion-Induced Superstructure Formation of a Rigid Polyanion
  Zi Liang Wu; Riku Takahashi; Daisuke Sawada; Md. Arifuzzaman; Tasuku Nakajima; Takayuki Kurokawa; Jian Hu; Jian Ping Gong
  MACROMOLECULES, 47, 20, 7208, 7214, Oct. 2014, [Peer-reviewed]
  English, Scientific journal
• Significant increase in Young's modulus of ATDC5 cells during chondrogenic differentiation induced by PAMPS/PDMAAm double-network gel: Comparison with induction by insulin
  Eijiro Maeda; Takehiro Tsutsumi; Nobuto Kitamura; Takayuki Kurokawa; Jian Ping Gong; Kazunori Yasuda; Toshiro Ohashi
  JOURNAL OF BIOMECHANICS, 47, 13, 3408, 3414, Oct. 2014, [Peer-reviewed]
  English, Scientific journal
• Effects of culture on PAMPS/PDMAAm double-network gel on chondrogenic differentiation of mouse C3H10T1/2 cells: in vitro experimental study
  Yusuke Inagaki; Nobuto Kitamura; Takayuki Kurokawa; Yasuhito Tanaka; Jian P. Gong; Kazunori Yasuda; Harukazu Tohyama
  BMC MUSCULOSKELETAL DISORDERS, 15, 320, Sep. 2014, [Peer-reviewed]
  English, Scientific journal
• Crack Blunting and Advancing Behaviors of Tough and Self-healing Polyampholyte Hydrogel
  Feng Luo; Tao Lin Sun; Tasuku Nakajima; Takayuki Kurokawa; Yu Zhao; Abu Bin Ihsan; Hong Lei Guo; Xu Feng Li; Jian Ping Gong
  MACROMOLECULES, 47, 17, 6037, 6046, Sep. 2014, [Peer-reviewed]
  English, Scientific journal
• Mechano-actuated ultrafast full-colour switching in layered photonic hydrogels
  Youfeng Yue; Takayuki Kurokawa; Md Anamul Haque; Tasuku Nakajima; Takayuki Nonoyama; Xufeng Li; Itsuro Kajiwara; Jian Ping Gong
  NATURE COMMUNICATIONS, 5, 4659, Aug. 2014, [Peer-reviewed]
  English, Scientific journal
• Control superstructure of rigid polyelectrolytes in oppositely charged hydrogels via programmed internal stress
  Riku Takahashi; Zi Liang Wu; Md Arifuzzaman; Takayuki Nonoyama; Tasuku Nakajima; Takayuki Kurokawa; Jian Ping Gong
  NATURE COMMUNICATIONS, 5, 4490, Aug. 2014, [Peer-reviewed]
  English, Scientific journal
• Hyaluronic acid enhances the effect of the PAMPS/PDMAAm double-network hydrogel on chondrogenic differentiation of ATDC5 cells
  Nobuto Kitamura; Takayuki Kurokawa; Takaaki Fukui; Jian P. Gong; Kazunori Yasuda
  BMC MUSCULOSKELETAL DISORDERS, 15, 222, Jul. 2014, [Peer-reviewed]
  English, Scientific journal
• Fracture Process of Microgel-Reinforced Hydrogels under Uniaxial Tension
  Jian Hu; Takayuki Kurokawa; Tasuku Nakajima; Zi Liang Wu; Song Miao Liang; Jian Ping Gong
  MACROMOLECULES, 47, 11, 3587, 3594, Jun. 2014, [Peer-reviewed]
  English, Scientific journal
• Sliding Friction of Zwitterionic Hydrogel and Its Electrostatic Origin
  Jamil Ahmed; Honglei Guo; Tetsurou Yamamoto; Takayuki Kurokawa; Masakazu Takahata; Tasuku Nakajima; Jian Ping Gong
  MACROMOLECULES, 47, 9, 3101, 3107, May 2014, [Peer-reviewed]
  English, Scientific journal
• Materials both Tough and Soft
  Jian Ping Gong
  SCIENCE, 344, 6180, 161, 162, Apr. 2014, [Invited]
  English, Scientific journal
• Intra-articular administration of hyaluronic acid increases the volume of the hyaline cartilage regenerated in a large osteochondral defect by implantation of a double-network gel
  Takaaki Fukui; Nobuto Kitamura; Takayuki Kurokawa; Masashi Yokota; Eiji Kondo; Jian Ping Gong; Kazunori Yasuda
  JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 25, 4, 1173, 1182, Apr. 2014, [Peer-reviewed]
  English, Scientific journal
• 一軸配向二分子膜によるハイドロゲルの高靱性化
  中島 祐; グン剣萍
  超分子研究会アニュアルレビュー, 34, 14, 15, Mar. 2014, [Invited]
  Japanese, Scientific journal
• Polyelectrolyte hydrogels for replacement and regeneration of biological tissues
  Hyuck Joon Kwon; Kazunori Yasuda; Jian Ping Gong; Yoshihiro Ohmiya
  MACROMOLECULAR RESEARCH, 22, 3, 227, 235, Mar. 2014, [Peer-reviewed], [Invited]
  English, Scientific journal
• Prolonged morphometric study of barnacles grown on soft substrata of hydrogels and elastomers
  Nafees Ahmed; Takayuki Murosaki; Takayuki Kurokawa; Akira Kakugo; Shintaro Yashima; Yasuyuki Nogata; Jian Ping Gong
  BIOFOULING, 30, 3, 271, 279, Mar. 2014, [Peer-reviewed]
  English, Scientific journal
• Brittle-ductile transition of double network hydrogels: Mechanical balance of two networks as the key factor
  Saika Ahmed; Tasuku Nakajima; Takayuki Kurokawa; Md Anamul Haque; Jian Ping Gong
  POLYMER, 55, 3, 914, 923, Feb. 2014, [Peer-reviewed]
  English, Scientific journal
• In situ observation of a hydrogel-glass interface during sliding friction
  Tetsurou Yamamoto; Takayuki Kurokawa; Jamil Ahmed; Gen Kamita; Shintaro Yashima; Yuichiro Furukawa; Yuko Ota; Hidemitsu Furukawa; Jian Ping Gong
  SOFT MATTER, 10, 30, 5589, 5596, 2014, [Peer-reviewed]
  English, Scientific journal
• Friction of hydrogels with controlled surface roughness on solid flat substrates
  Shintaro Yashima; Natsuko Takase; Takayuki Kurokawa; Jian Ping Gong
  SOFT MATTER, 10, 18, 3192, 3199, 2014, [Peer-reviewed]
  English, Scientific journal
• Proteoglycans and Glycosaminoglycans Improve Toughness of Biocompatible Double Network Hydrogels
  Yu Zhao; Tasuku Nakajima; Jing Jing Yang; Takayuki Kurokawa; Jian Liu; Jishun Lu; Shuji Mizumoto; Kazuyuki Sugahara; Nobuto Kitamura; Kazunori Yasuda; A. U. D. Daniels; Jian Ping Gong
  ADVANCED MATERIALS, 26, 3, 436, 442, Jan. 2014, [Peer-reviewed]
  English, Scientific journal
• Hydrogel friction and lubrication
  Jian Liu; Jian Ping Gong
  Aqueous Lubrication: Natural and Biomimetic Approaches, 145, 181, World Scientific Publishing Co., 01 Jan. 2014
  English, In book
• Geometric and edge effects on swelling-induced ordered structure formation in polyelectrolyte hydrogels
  Md. Arifuzzaman; Zi Liang Wu; Riku Takahashi; Takayuki Kurokawa; Tasuku Nakajima; Jian Ping Gong
  Macromolecules, 46, 22, 9083, 9090, 26 Nov. 2013, [Peer-reviewed]
  English, Scientific journal
• Fracture energy of polymer gels with controlled network structures
  Yuki Akagi; Hayato Sakurai; Jian Ping Gong; Ung-il Chung; Takamasa Sakai
  JOURNAL OF CHEMICAL PHYSICS, 139, 14, 144905-1, 144905-6, Oct. 2013, [Peer-reviewed]
  English, Scientific journal
• Physical hydrogels composed of polyampholytes demonstrate high toughness and viscoelasticity
  Tao Lin Sun; Takayuki Kurokawa; Shinya Kuroda; Abu Bin Ihsan; Taigo Akasaki; Koshiro Sato; Md Anamul Haque; Tasuku Nakajima; Jian Ping Gong
  NATURE MATERIALS, 12, 10, 932, 937, Oct. 2013, [Peer-reviewed]
  English, Scientific journal
• Hydrogel with Unidirectional Alignment of Lamellar Bilayers: Its Structural Color and Mechanical Response
  Koshiro Sato; Md. Anamul Haque; Gen Kamita; You Feng Yue; Takayuki Kurokawa; Jian Ping Gong
  Journal of the Japan Society of Colour Material, 86, 8, 290, 294, Japan Society of Colour Material, Aug. 2013, [Peer-reviewed], [Invited]
  Japanese, Scientific journal, A lot of animals and plants have structural color consisted of ordered structure. Recently attempts to introduce this ordered structure into polymer are attracting extensive attention in the field of sensor. We pay attention to dodecylglyceryl itaconate (DGI) that can form periodically ordered bilayer structure in water. This review describes synthesis, anisotropic structure and mechanical properties, and stress/straininduced change in structural color of a photonic hydrogel with ordered structure consisting of DGI and acrylamide.
• DNゲルによるATDC5細胞の軟骨分化誘導に関する力学的機序の解明 1細胞の力学的特性の変化とアクチン修飾タンパク質発現との関連
  前田 英次郎; 堤 健博; 黒川 孝幸; 北村 信人; Gong Jian Ping; 安田 和則; 大橋 俊朗
  日本整形外科学会雑誌, 87, 8, S1408, S1408, (公社)日本整形外科学会, Aug. 2013
  Japanese
• Tuning Mechanical Properties of Chondroitin Sulfate-Based Double-Network Hydrogels
  Tiffany C. Suekama; Jian Hu; Takayuki Kurokawa; Jian Ping Gong; Stevin H. Gehrke
  MACROMOLECULAR SYMPOSIA, 329, 1, 9, 18, Jul. 2013, [Peer-reviewed], [Invited]
  English, International conference proceedings
• Optical and mechanical properties of a hydrogel based on lamellar bilayers
  Takayuki Kurokawa; Md. Anamul Haque; Jian Ping Gong
  Kobunshi Ronbunshu, 70, 7, 309, 316, Jul. 2013, [Peer-reviewed], [Invited]
  Japanese, Scientific journal
• Multi-functions of hydrogel with bilayer-based lamellar structure
  Md. Anamul Haque; Jian Ping Gong
  REACTIVE & FUNCTIONAL POLYMERS, 73, 7, 929, 935, Jul. 2013, [Peer-reviewed], [Invited]
  English, Scientific journal
• Lamellar hydrogels with high toughness and ternary tunable photonic stop-band
  You Feng Yue; M. Anamul Haque; Takayuki Kurokawa; Tasuku Nakajima; Jian Ping Gong
  Advanced Materials, 25, 22, 3106, 3110, 11 Jun. 2013, [Peer-reviewed]
  English, Scientific journal
• Synthesis and Fracture Process Analysis of Double Network Hydrogels with a Well-Defined First Network
  Tasuku Nakajima; Yuki Fukuda; Takayuld Kurokawa; Takamasa Sakai; Ung-il Chung; Jian Ping Gong
  ACS MACRO LETTERS, 2, 6, 518, 521, Jun. 2013, [Peer-reviewed]
  English, Scientific journal
• Supramolecular Assemblies of a Semirigid Polyanion in Aqueous Solutions
  Zi Liang Wu; Md. Arifuzzaman; Takayuki Kurokawa; Khoa Le; Jian Hu; Tao Lin Sun; Hidemitsu Furukawa; Hiroyasu Masunaga; Jian Ping Gong
  MACROMOLECULES, 46, 9, 3581, 3586, May 2013, [Peer-reviewed]
  English, Scientific journal
• Double-network acrylamide hydrogel compositions adapted to achieve cartilage-like dynamic stiffness
  S. Ronken; D. Wirz; A. U. Daniels; T. Kurokawa; J. P. Gong; M. P. Arnold
  BIOMECHANICS AND MODELING IN MECHANOBIOLOGY, 12, 2, 243, 248, Apr. 2013, [Peer-reviewed]
  English, Scientific journal
• Relaxation modes in chemically cross-linked poly(2-methacryloyloxyethyl phosphorylcholine) hydrogels
  Tatsuro Goda; Hidemitsu Furukawa; Jian Ping Gong; Kazuhiko Ishihara
  Soft Matter, 9, 7, 2166, 2171, Royal Society of Chemistry, 21 Feb. 2013, [Peer-reviewed]
  English, Scientific journal
• 海の生き物に学ぶ低環境負荷型抗付着材料の創製 : フジツボに対するハイドロゲルの抗付着効果
  黒川 孝幸; 龔 剣萍; 室﨑 喬之; 野方 靖行
  PEN, 3, 11, 3, 8, 産業技術総合研究所, Feb. 2013, [Invited]
  Japanese, Scientific journal, 海辺を散歩するとフジツボ類や貝類、藻類等の岩場にへばりついて生きている生物をよく見ることができる。これら海洋付着生物は海洋資源として有用な反面、汚損生物として負の側面も持ち合わせている。例を挙げると、船底に付着する事で水の抵抗が増し船の燃費を増大させる、養殖漁網の網の目を詰まらせる事で養殖魚を窒息死させる、取水口を詰まらせる事で臨海発電所の冷却機能を低下させる等があり、海洋付着生物は世界中のあらゆる海に関わる産業に大きな経済的損失を与えている
• Hyaluronic acid affects the in vitro induction effects of Synthetic PAMPS and PDMAAm hydrogels on chondrogenic differentiation of ATDC5 cells, depending on the level of concentration
  Katsuhisa Yoshikawa; Nobuto Kitamura; Takayuki Kurokawa; Jian Ping Gong; Yutaka Nohara; Kazunori Yasuda
  BMC MUSCULOSKELETAL DISORDERS, 14, 56, Feb. 2013, [Peer-reviewed]
  English, Scientific journal
• Double-Network Strategy Improves Fracture Properties of Chondroitin Sulfate Networks
  Tiffany C. Suekama; Jian Hu; Takayuki Kurokawa; Jian Ping Gong; Stevin H. Gehrke
  ACS MACRO LETTERS, 2, 2, 137, 140, Feb. 2013, [Peer-reviewed]
  English, Scientific journal
• Transition between Phantom and Affine Network Model Observed in Polymer Gels with Controlled Network Structure
  Yuki Akagi; Jian Ping Gong; Ung-il Chung; Takamasa Sakai
  MACROMOLECULES, 46, 3, 1035, 1040, Feb. 2013, [Peer-reviewed]
  English, Scientific journal
• A phase diagram of neutral polyampholyte - from solution to tough hydrogel
  Abu Bin Ihsan; Tao Lin Sun; Shinya Kuroda; Md. Anamul Haque; Takayuki Kurokawa; Tasuku Nakajima; Jian Ping Gong
  JOURNAL OF MATERIALS CHEMISTRY B, 1, 36, 4555, 4562, 2013, [Peer-reviewed]
  English, Scientific journal
• Barnacle Settlement Behavior on Natural Polymer Gels
  Takayuki Murosaki; Takaya Noguchi; Yasuyuki Nogata; Jian Ping Gong
  KOBUNSHI RONBUNSHU, 70, 7, 326, 330, 2013, [Peer-reviewed], [Invited]
  Japanese, Scientific journal
• Double network hydrogels from polyzwitterions: high mechanical strength and excellent anti-biofouling properties
  Haiyan Yin; Taigo Akasaki; Tao Lin Sun; Tasuku Nakajima; Takayuki Kurokawa; Takayuki Nonoyama; Toshio Taira; Yoshiyuki Saruwatari; Jian Ping Gong
  JOURNAL OF MATERIALS CHEMISTRY B, 1, 30, 3685, 3693, 2013, [Peer-reviewed]
  English, Scientific journal
• Growth of ring-shaped microtubule assemblies through stepwise active self-organisation
  Daisuke Inoue; Arif Md Rashedul Kabir; Hiroyuki Mayama; Jian Ping Gong; Kazuki Sada; Akira Kakugo
  SOFT MATTER, 9, 29, 7061, 7068, 2013, [Peer-reviewed]
  English, Scientific journal
• Lamellar-micelle transition in a hydrogel induced by polyethylene glycol grafting
  Md Anamul Haque; Takayuki Kurokawa; Jian Ping Gong
  SOFT MATTER, 9, 21, 5223, 5230, 2013, [Peer-reviewed]
  English, Scientific journal
• Influence of the gel thickness on in vivo hyaline cartilage regeneration induced by double-network gel implanted at the bottom of a large osteochondral defect: Short-term results
  Hidetoshi Matsuda; Nobuto Kitamura; Takayuki Kurokawa; Kazunobu Arakaki; Jian Ping Gong; Fuminori Kanaya; Kazunori Yasuda
  BMC MUSCULOSKELETAL DISORDERS, 14, 50, Jan. 2013, [Peer-reviewed]
  English, Scientific journal
• Relaxation Modes in Chemically Cross-linked Poly(2-methacryloyloxyethyl phosphorylcholine) Hydrogel
  Tatsuro Goda; Hidemitsu Furukawa; Jian Ping Gong; Kazuhiko Ishihara
  Soft Matter, 9, 7, 2166, 2171, Jan. 2013, [Peer-reviewed]
  English, Scientific journal
• Characterization of internal fracture process of double network hydrogels under uniaxial elongation
  Tasuku Nakajima; Takayuki Kurokawa; Saika Ahmed; Wen-li Wu; Jian Ping Gong
  SOFT MATTER, 9, 6, 1955, 1966, 2013, [Peer-reviewed]
  English, Scientific journal
• High fracture efficiency and stress concentration phenomenon for microgel-reinforced hydrogels based on double-network principle
  Jian Hu; Takayuki Kurokawa; Tasuku Nakajima; Tao Lin Sun; Tiffany Suekama; Zi Liang Wu; Song Miao Liang; Jian Ping Gong
  Macromolecules, 45, 23, 9445, 9451, 11 Dec. 2012, [Peer-reviewed]
  English, Scientific journal
• A Universal Molecular Stent Method to Toughen any Hydrogels Based on Double Network Concept
  Tasuku Nakajima; Hitomi Sato; Yu Zhao; Shinya Kawahara; Takayuki Kurokawa; Kazuyuki Sugahara; Jian Ping Gong
  ADVANCED FUNCTIONAL MATERIALS, 22, 21, 4426, 4432, Nov. 2012, [Peer-reviewed]
  English, Scientific journal
• Poly(2-acrylamido-2-methylpropanesulfonic acid) gel induces articular cartilage regeneration in vivo: Comparisons of the induction ability between single- and double-network gels
  Munehiro Ogawa; Nobuto Kitamura; Takayuki Kurokawa; Kazunobu Arakaki; Yasuhito Tanaka; Jian Ping Gong; Kazunori Yasuda
  JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 100A, 9, 2244, 2251, Sep. 2012, [Invited]
  English, Scientific journal
• 埋植されるPAMPS/PDMAAmダブルネットワークゲルシートの厚さがそのin vivo硝子軟骨再生誘導能に与える効果
  松田 英敏; 北村 信人; 黒川 孝幸; 新垣 和伸; Gong Jian Ping; 金谷 文則; 安田 和則
  日本整形外科学会雑誌, 86, 8, S1139, S1139, (公社)日本整形外科学会, Aug. 2012
  Japanese
• Hydrogels with a macroscopic-scale liquid crystal structure by self-assembly of a semi-rigid polyion complex
  Zii Liang Wu; Takayuki Kurokawa; Jian Ping Gong
  POLYMER JOURNAL, 44, 6, 503, 511, Jun. 2012, [Peer-reviewed]
  English, Scientific journal
• Structure Optimization and Mechanical Model for Microgel-Reinforced Hydrogels with High Strength and Toughness
  Jian Hu; Takayuki Kurokawa; Kenta Hiwatashi; Tasuku Nakajima; Zi Liang Wu; Song Miao Liang; Jian Ping Gong
  MACROMOLECULES, 45, 12, 5218, 5228, Jun. 2012, [Peer-reviewed]
  English, Scientific journal
• Toughness Enhancement and Stick-Slip Tearing of Double-Network Hydrogels in Poly(ethylene glycol) Solution
  Songmiao Liang; Jian Flu; Zi Liang Wu; Takayuki Kurokawa; Jian Ping Gong
  MACROMOLECULES, 45, 11, 4758, 4763, Jun. 2012, [Peer-reviewed]
  English, Scientific journal
• Active self-organization of microtubules in an inert chamber system
  Arif Md Rashedul Kabir; Daisuke Inoue; Akira Kakugo; Kazuki Sada; Jian Ping Gong
  POLYMER JOURNAL, 44, 6, 607, 611, Jun. 2012, [Peer-reviewed]
  English, Scientific journal
• Self-assembled structures of a semi-rigid polyanion in aqueous solutions and hydrogels
  Sun TaoLin; Wu ZiLiang; Gong JianPing
  SCIENCE CHINA-CHEMISTRY, 55, 5, 735, 742, May 2012, [Peer-reviewed]
  English, Scientific journal
• Super tough double network hydrogels and their application as biomaterials
  Md. Anamul Haque; Takayuki Kurokawa; Jian Ping Gong
  POLYMER, 53, 9, 1805, 1822, Apr. 2012, [Peer-reviewed]
  English, Scientific journal
• 生体分子モーターの自発的高次構造形成
  敷中一洋; 角五 彰; 龔 剣萍
  液晶, 16, 1, 45, 51, Jan. 2012, [Invited]
  Japanese, Scientific journal
• Anisotropic hydrogel based on bilayers: color, strength, toughness, and fatigue resistance
  Md Anamul Haque; Takayuki Kurokawa; Jian Ping Gong
  SOFT MATTER, 8, 31, 8008, 8016, 2012, [Peer-reviewed], [Invited]
  English, Scientific journal
• Nematic growth of microtubules that changed into giant spiral structure through partial depolymerization and subsequent dynamic ordering
  Kiyotaka Shigehara; Hiroki Kudoh; Saori Mori; Yoshiki Tamura; Akira Kakugo; Ryuzo Kawamura; Hidemitsu Furukawa; Jian Ping Gong; Hiroyasu Masunaga; Tomomi Masui; Satoshi Koizumi; Kazuhiro Shikinaka
  SOFT MATTER, 8, 45, 11544, 11551, 2012, [Peer-reviewed]
  English, Scientific journal
• Formation of ring-shaped assembly of microtubules with a narrow size distribution at an air-buffer interface
  Arif Md Rashedul Kabir; Shoki Wada; Daisuke Inoue; Yoshiki Tamura; Tamaki Kajihara; Hiroyuki Mayama; Kazuki Sada; Akira Kakugo; Jian Ping Gong
  SOFT MATTER, 8, 42, 10863, 10867, 2012, [Peer-reviewed]
  English, Scientific journal
• Swelling-induced long-range ordered structure formation in polyelectrolyte hydrogel
  Md Arifuzzaman; Zi Liang Wu; Takayuki Kurokawa; Akira Kakugo; Jian Ping Gong
  SOFT MATTER, 8, 31, 8060, 8066, 2012, [Peer-reviewed]
  English, Scientific journal
• Antifouling properties of hydrogels
  Takayuki Murosaki; Nafees Ahmed; Jian Ping Gong
  SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS, 12, 6, 064706, Dec. 2011, [Peer-reviewed], [Invited]
  English, Scientific journal
• Formation of motile assembly of microtubules driven by kinesins
  Ryuzo Kawamura; Akira Kakugo; Kazuhiro Shikinaka; Yoshihito Osada; Jian Ping Gong
  SMART MATERIALS AND STRUCTURES, 20, 12, 124007, Dec. 2011, [Peer-reviewed]
  English, Scientific journal
• Novel Developed Systems and Techniques Based on Double-Network Principle
  Zi Liang Wu; Takayuki Kurokawa; Jian Ping Gong
  BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 84, 12, 1295, 1311, Dec. 2011, [Peer-reviewed]
  English, Scientific journal
• Rapid and Reversible Tuning of Structural Color of a Hydrogel over the Entire Visible Spectrum by Mechanical Stimulation
  Md. Anamul Haque; Takayuki Kurokawa; Gen Kamita; Youfeng Yue; Jian Ping Gong
  CHEMISTRY OF MATERIALS, 23, 23, 5200, 5207, Dec. 2011, [Peer-reviewed]
  English, Scientific journal
• Lamellar Bilayers as Reversible Sacrificial Bonds To Toughen Hydrogel: Hysteresis, Self-Recovery, Fatigue Resistance, and Crack Blunting
  M. Anamul Haque; Takayuki Kurokawa; Gen Kamita; J. Ping Gong
  MACROMOLECULES, 44, 22, 8916, 8924, Nov. 2011, [Peer-reviewed]
  English, Scientific journal
• Effect of Hyaluronan Solution on Dynamic Friction of PVA Gel Sliding on Weakly Adhesive Glass Substrate
  Yukihiro Nakano; Takayuki Kurokawa; Miao Du; Jian Liu; Taiki Tominaga; Yoshihito Osada; Jian Ping Gong
  MACROMOLECULES, 44, 22, 8908, 8915, Nov. 2011, [Peer-reviewed]
  English, Scientific journal
• Prolongation of the Active Lifetime of a Biomolecular Motor for in Vitro Motility Assay by Using an Inert Atmosphere
  Arif Md. Rashedul Kabir; Daisuke Inoue; Akira Kakugo; Akiko Kamei; Jian Ping Gong
  LANGMUIR, 27, 22, 13659, 13668, Nov. 2011, [Peer-reviewed]
  English, Scientific journal
• How to Integrate Biological Motors towards Bio-Actuators Fueled by ATP
  Arif Md. Rashedul Kabir; Akira Kakugo; Jian Ping Gong; Yoshihito Osada
  MACROMOLECULAR BIOSCIENCE, 11, 10, 1314, 1324, Oct. 2011, [Invited]
  English, Scientific journal
• Controlled Clockwise-Counterclockwise Motion of the Ring-Shaped Microtubules Assembly
  Akira Kakugo; Arif Md. Rashedul Kabir; Natsuki Hosoda; Kazuhiro Shikinaka; Jian Ping Gong
  BIOMACROMOLECULES, 12, 10, 3394, 3399, Oct. 2011, [Peer-reviewed]
  English, Scientific journal
• Microgel-Reinforced Hydrogel Films with High Mechanical Strength and Their Visible Mesoscale Fracture Structure
  Jian Hu; Kenta Hiwatashi; Takayuki Kurokawa; Song Miao Liang; Zi Liang Wu; Jian Ping Gong
  MACROMOLECULES, 44, 19, 7775, 7781, Oct. 2011, [Peer-reviewed]
  English, Scientific journal
• Acrylamide Polymer Double-Network Hydrogels: Candidate Cartilage Repair Materials with Cartilage-Like Dynamic Stiffness and Attractive Surgery-Related Attachment Mechanics
  Markus P. Arnold; Alma U. Daniels; Sarah Ronken; Helena Ardura Garcia; Niklaus F. Friederich; Takayuki Kurokawa; Jian P. Gong; Dieter Wirz
  CARTILAGE, 2, 4, 374, 383, Oct. 2011, [Peer-reviewed]
  English, Scientific journal
• Gel: A Potential Material as Artificial Soft Tissue
  Yong Mei Chen; Jian Ping Gong; Yoshihito Osada
  Macromolecular Engineering: Precise Synthesis, Materials Properties, Applications, 4, 2689, 2717, Wiley-VCH, 23 Sep. 2011, [Peer-reviewed]
  English, In book
• Gene expression profile of the cartilage tissue spontaneously regenerated in vivo by using a novel double-network gel: Comparisons with the normal articular cartilage
  Ryusei Imabuchi; Yoshihiro Ohmiya; Hyuck Joon Kwon; Shin Onodera; Nobuto Kitamura; Takayuki Kurokawa; Jian Ping Gong; Kazunori Yasuda
  BMC MUSCULOSKELETAL DISORDERS, 12, 213, Sep. 2011, [Peer-reviewed]
  English, Scientific journal
• Dynamic Behavior and Spontaneous Differentiation of Mouse Embryoid Bodies on Hydrogel Substrates of Different Surface Charge and Chemical Structures
  Jian Fang Liu; Yong Mei Chen; Jing Jing Yang; Takayuki Kurokawa; Akira Kakugo; Kimiko Yamamoto; Jian Ping Gong
  TISSUE ENGINEERING PART A, 17, 17-18, 2343, 2357, Sep. 2011, [Peer-reviewed]
  English, Scientific journal
• PAMPS/PDMAAmダブルネットワークゲルが培養ATDC5細胞の軟骨分化に与える効果 PAMPSおよびPDMAAmゲルの効果との比較
  北村 信人; 権 赫準; 近江谷 克裕; 黒川 孝幸; グン 剣萍; 安田 和則
  日本整形外科学会雑誌, 85, 8, S1264, S1264, (公社)日本整形外科学会, Aug. 2011
  Japanese
• ゲル-物性の研究と再生医療への応用
  黒川孝幸; 龔剣萍
  未来材料, 11, 8, 2, 4, エヌ・ティー・エス, Aug. 2011, [Invited]
  Japanese, Scientific journal
• Surfactant-induced friction reduction for hydrogels in the boundary lubrication regime
  Kosuke Kamada; Hidemitsu Furukawa; Takayuki Kurokawa; Tomohiro Tada; Taiki Tominaga; Yukihiro Nakano; Jian Ping Gong
  JOURNAL OF PHYSICS-CONDENSED MATTER, 23, 28, 284107, Jul. 2011, [Peer-reviewed]
  English, Scientific journal
• Effect of void structure on the toughness of double network hydrogels
  Tasuku Nakajima; Hidemitsu Furukawa; Yoshimi Tanaka; Takayuki Kurokawa; Jian Ping Gong
  Journal of Polymer Science Part B: Polymer Physics, 49, 17, 1246, 1254, 28 Jun. 2011, [Peer-reviewed], [Last author, Corresponding author], [International Magazine]
  English, Scientific journal
• Hydrogels with self-assembling ordered structures and their functions
  Zi Liang Wu; Jian Ping Gong
  NPG ASIA MATERIALS, 3, 4, 57, 64, Jun. 2011, [Peer-reviewed], [Invited]
  English, Scientific journal
• Induction of Spontaneous Hyaline Cartilage Regeneration Using a Double-Network Gel Efficacy of a Novel Therapeutic Strategy for an Articular Cartilage Defect
  Nobuto Kitamura; Kazunori Yasuda; Munehiro Ogawa; Kazunobu Arakaki; Shuken Kai; Shin Onodera; Takayuki Kurokawa; Jian Ping Gong
  AMERICAN JOURNAL OF SPORTS MEDICINE, 39, 6, 1160, 1169, Jun. 2011, [Invited]
  English, Scientific journal
• Strain-Induced Molecular Reorientation and Birefringence Reversion of a Robust, Anisotropic Double-Network Hydrogel
  Zi Liang Wu; Daisuke Sawada; Takayuki Kurokawa; Akira Kakugo; Wei Yang; Hidemitsu Furukawa; Jian Ping Gong
  MACROMOLECULES, 44, 9, 3542, 3547, May 2011, [Peer-reviewed]
  English, Scientific journal
• Anisotropic Hydrogel from Complexation-Driven Reorientation of Semirigid Polyanion at Ca2+ Diffusion Flux Front
  Zi Liang Wu; Takayuki Kurokawa; Daisuke Sawada; Jian Hu; Hidemitsu Furukawa; Jian Ping Gong
  MACROMOLECULES, 44, 9, 3535, 3541, May 2011, [Peer-reviewed]
  English, Scientific journal
• Direct Observation on the Surface Fracture of Ultrathin Film Double-Network Hydrogels
  Songmiao Liang; Zi Liang Wu; Jian Hu; Takayuki Kurokawa; Qiu Ming Yu; Jian Ping Gong
  MACROMOLECULES, 44, 8, 3016, 3020, Apr. 2011, [Peer-reviewed]
  English, Scientific journal
• Robust bonding and one-step facile synthesis of tough hydrogels with desirable shape by virtue of the double network structure
  Junji Saito; Hidemitsu Furukawa; Takayuki Kurokawa; Rikimaru Kuwabara; Shinya Kuroda; Jian Hu; Yoshimi Tanaka; Jian Ping Gong; Nobuto Kitamura; Kazunori Yasuda
  POLYMER CHEMISTRY, 2, 3, 575, 580, Mar. 2011, [Peer-reviewed]
  English, Scientific journal
• Joint immobilization inhibits spontaneous hyaline cartilage regeneration induced by a novel double-network gel implantation
  Kazunobu Arakaki; Nobuto Kitamura; Takayuki Kurokawa; Shin Onodera; Fuminori Kanaya; Jian-Ping Gong; Kazunori Yasuda
  JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 22, 2, 417, 425, Feb. 2011, [Peer-reviewed]
  English, Scientific journal
• Spontaneous hyaline cartilage regeneration can be induced in an osteochondral defect created in the femoral condyle using a novel double-network hydrogel
  Masashi Yokota; Kazunori Yasuda; Nobuto Kitamura; Kazunobu Arakaki; Shin Onodera; Takayuki Kurokawa; Jian-Ping Gong
  BMC MUSCULOSKELETAL DISORDERS, 12, -, 49, -, Feb. 2011, [Peer-reviewed]
  English, Scientific journal
• Synthetic hydrogels as scaffolds for manipulating endothelium cell behaviors
  Yong-mei Chen; Jing-jing Yang; Yoshihito Osada; Jian Ping Gong
  CHINESE JOURNAL OF POLYMER SCIENCE, 29, 1, 23, 41, Jan. 2011, [Peer-reviewed], [Invited]
  English, Scientific journal
• Long-term in situ observation of barnacle growth on soft substrates with different elasticity and wettability
  Nafees Ahmed; Takayuki Murosaki; Akira Kakugo; Takayuki Kurokawa; Jian Ping Gong; Yasuyuki Nogata
  SOFT MATTER, 7, 16, 7281, 7290, 2011, [Peer-reviewed]
  English, Scientific journal
• Dynamic self-organization and polymorphism of microtubule assembly through active interactions with kinesin
  Yoshiki Tamura; Ryuzo Kawamura; Kazuhiro Shikinaka; Akira Kakugo; Yoshihito Osada; Jian Ping Gong; Hiroyuki Mayama
  SOFT MATTER, 7, 12, 5654, 5659, 2011, [Peer-reviewed]
  English, Scientific journal
• Hydrogel with cubic-packed giant concentric domains of semi-rigid polyion complex
  Zi Liang Wu; Md Arifuzzaman; Takayuki Kurokawa; Hidemitsu Furukawa; Jian Ping Gong
  SOFT MATTER, 7, 5, 1884, 1889, 2011, [Peer-reviewed]
  English, Scientific journal
• Unidirectional Alignment of Lamellar Bilayer in Hydrogel: One-Dimensional Swelling, Anisotropic Modulus, and Stress/Strain Tunable Structural Color
  Md. Anamul Haque; Gen Kamita; Takayuki Kurokawa; Kaoru Tsujii; Jian Ping Gong
  ADVANCED MATERIALS, 22, 45, 5110, +, Dec. 2010, [Peer-reviewed]
  English, Scientific journal
• 海藻にフジツボが付着しないのはなぜか−海藻に学ぶ抗生物付着ゲルの開発−
  室﨑喬之; 龔剣萍
  BIOINDUSTRY, 27, 12, 63, 71, Nov. 2010, [Invited]
  Japanese, Scientific journal
• Study on the Sliding Friction of Endothelial Cells Cultured on Hydrogel and the Role of Glycocalyx on Friction Reduction
  Yong Mei Chen; Takayuki Kurokawa; Taiki Tominaga; Kazunori Yasuda; Yoshihito Osada; Jian Ping Gong; Kimiko Yamamoto; Joji Ando
  ADVANCED ENGINEERING MATERIALS, 12, 11, B628, B636, Nov. 2010, [Peer-reviewed]
  English, Scientific journal
• Water-Induced Brittle-Ductile Transition of Double Network Hydrogels
  Hiroko Itagaki; Takayuki Kurokawa; Hidemitsu Furukawa; Tasuku Nakajima; Yukiteru Katsumoto; Jian Ping Gong
  MACROMOLECULES, 43, 22, 9495, 9500, Nov. 2010, [Peer-reviewed]
  English, Scientific journal
• Gene expression, glycocalyx assay, and surface properties of human endothelial cells cultured on hydrogel matrix with sulfonic moiety: Effect of elasticity of hydrogel
  Jing Jing Yang; Yong Mei Chen; Takayuki Kurokawa; Jian Ping Gong; Shin Onodera; Kazunori Yasuda
  JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 95A, 2, 531, 542, Nov. 2010, [Peer-reviewed]
  English, Scientific journal
• Dual Network Formation in Polyelectrolyte Hydrogel via Viscoelastic Phase Separation: Role of Ionic Strength and Polymerization Kinetics
  Zi Liang Wu; Takayuki Kurokawa; Songmiao Liang; Jian Ping Gong
  MACROMOLECULES, 43, 19, 8202, 8208, Oct. 2010, [Peer-reviewed]
  English, Scientific journal
• An Approach towards Artificial Biotissues
  KAKUGO Akira; GONG JianPing
  Seibutsu Butsuri, 50, 5, 244, 247, The Biophysical Society of Japan General Incorporated Association, 25 Sep. 2010
  Japanese
• PAMPSおよびPDMAAmゲルはPAMPS/PDMAAmダブルネットワークゲルと同じ関節軟骨自然再生誘導能を有するか
  小川 宗宏; 北村 信人; 新垣 和伸; 黒川 孝幸; Gong Jian Ping; 田中 康仁; 高倉 義典; 安田 和則
  日本整形外科学会雑誌, 84, 8, S1061, S1061, (公社)日本整形外科学会, Aug. 2010
  Japanese
• Spontaneous Redifferentiation of Dedifferentiated Human Articular Chondrocytes on Hydrogel Surfaces
  Jing Jing Yang; Yong Mei Chen; Jian Fang Liu; Takayuki Kurokawa; Jian Ping Gong
  TISSUE ENGINEERING PART A, 16, 8, 2529, 2540, Aug. 2010, [Peer-reviewed]
  English, Scientific journal
• 高強度ダブルネットワークゲル
  黒川孝幸; 龔剣萍
  化学工学会誌, 74, 7, 338, 340, Jul. 2010, [Invited]
  Japanese, Scientific journal
• Hydrogels with Cylindrically Symmetric Structure at Macroscopic Scale by Self-Assembly of Semi-rigid Polyion Complex
  Zi Liang Wu; Takayuki Kurokawa; Songmiao Liang; Hidemitsu Furukawa; Jian Ping Gong
  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 132, 29, 10064, 10069, Jul. 2010, [Peer-reviewed]
  English, Scientific journal
• A facile method for synthesizing free-shaped and tough double network hydrogels using physically crosslinked poly(vinyl alcohol) as an internal mold
  Tasuku Nakajima; Naoyuki Takedomi; Takayuki Kurokawa; Hidemitsu Furukawa; Jian Ping Gong
  POLYMER CHEMISTRY, 1, 5, 693, 697, Jul. 2010, [Peer-reviewed], [Invited]
  English, Scientific journal
• Artificial cartilage made from a novel double-network hydrogel: In vivo effects on the normal cartilage and ex vivo evaluation of the friction property
  Kazunobu Arakaki; Nobuto Kitamura; Hiroyuki Fujiki; Takayuki Kurokawa; Mikio Iwamoto; Masaru Ueno; Fuminori Kanaya; Yoshihito Osada; Jian Ping Gong; Kazunori Yasuda
  JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 93A, 3, 1160, 1168, Jun. 2010, [Peer-reviewed]
  English, Scientific journal
• Microtubule bundle formation driven by ATP: the effect of concentrations of kinesin, streptavidin and microtubules
  Ryuzo Kawamura; Akira Kakugo; Yoshihito Osada; Jian Ping Gong
  NANOTECHNOLOGY, 21, 14, 145603, Apr. 2010, [Peer-reviewed]
  English, Scientific journal
• Formation of a strong hydrogel-porous solid interface via the double-network principle
  Takayuki Kurokawa; Hidemitsu Furukawa; Wei Wang; Yoshimi Tanaka; Jian Ping Gong
  ACTA BIOMATERIALIA, 6, 4, 1353, 1359, Apr. 2010, [Peer-reviewed]
  English, Scientific journal
• 超高強度ダブルネットワークゲルの創製とその高強度化メカニズム
  中島 祐; 龔 剣萍
  物性研究, 93, 5, 551, 557, 物性研究刊行会, Feb. 2010, [Invited]
  Japanese, Scientific journal
• Ligament-like tough double-network hydrogel based on bacterial cellulose
  Yui Hagiwara; Ananda Putra; Akira Kakugo; Hidemitsu Furukawa; Jian Ping Gong
  CELLULOSE, 17, 1, 93, 101, Feb. 2010, [Peer-reviewed], [Invited]
  English, Scientific journal
• In vitro differentiation of chondrogenic ATDC5 cells is enhanced by culturing on synthetic hydrogels with various charge densities
  Hyuck Joon Kwon; Kazunori Yasuda; Yoshihiro Ohmiya; Ken-ichi Honma; Yong Mei Chen; Jian Ping Gong
  ACTA BIOMATERIALIA, 6, 2, 494, 501, Feb. 2010, [Peer-reviewed]
  English, Scientific journal
• Why are double network hydrogels so tough?
  Jian Ping Gong
  SOFT MATTER, 6, 12, 2583, 2590, 2010, [Peer-reviewed], [Invited]
  English, Scientific journal
• A Deformation Mechanism for Double-Network Hydrogels with Enhanced Toughness
  Tasuku Nakajima; Hidemitsu Furukawa; Jian Ping Gong; Eric K. Lin; Wen-li Wu
  POLYMER NETWORKS: SYNTHESIS, PROPERTIES, THEORY AND APPLICATIONS, 291-292, 122, +, 2010, [Peer-reviewed], [Invited]
  English, International conference proceedings
• Hierarchical structures of the actin/polycation complexes, investigated by ultra-small-angle neutron scattering and fluorescence microscopy
  Tomomi Masui; Satoshi Koizumi; Takeji Hashimoto; Kazuhiro Shikinaka; Akira Kakugo; Jian Ping Gong
  SOFT MATTER, 6, 9, 2021, 2030, 2010, [Peer-reviewed]
  English, Scientific journal
• A Polysaccharide-Based Container Transportation System Powered by Molecular Motors
  Youichi Tsuchiya; Tomotaka Komori; Minako Hirano; Tomohiro Shiraki; Akira Kakugo; Toru Ide; Jian-Ping Gong; Sunao Yamada; Toshio Yanagida; Seiji Shinkai
  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 49, 4, 724, 727, 2010, [Peer-reviewed]
  English, Scientific journal
• Selective Formation of a Linear-Shaped Bundle of Microtubules
  Ryuzo Kawamura; Akira Kakugo; Yoshihito Osada; Jian Ping Gong
  LANGMUIR, 26, 1, 533, 537, Jan. 2010, [Peer-reviewed]
  English, Scientific journal
• Formation of Well-Oriented Microtubules with Preferential Polarity in a Confined Space under a Temperature Gradient
  Akira Kakugo; Yoshiki Tamura; Kazuhiro Shikinaka; Momoko Yoshida; Ryuzo Kawamura; Hidemitsu Furukawa; Yoshihito Osada; Jian Ping Gong
  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 131, 50, 18089, 18095, Dec. 2009, [Peer-reviewed]
  English, Scientific journal
• Mesoscopic Network Structure of a Semi-Rigid Polyion Complex Nested in a Polycationic Hydrogel
  Zi Liang Wu; Hidemitsu Furukawa; Wei Yang; Jian Ping Gong
  ADVANCED MATERIALS, 21, 46, 4696, +, Dec. 2009, [Peer-reviewed]
  English, Scientific journal
• ATP-Fueled Soft Gel Machine with Well-Oriented Structure Constructed Using Actin-Myosin System
  Kazuhiro Shikinaka; Shintaro Takaoka; Akira Kakugo; Yoshihito Osada; Jian Ping Gong
  JOURNAL OF APPLIED POLYMER SCIENCE, 114, 4, 2087, 2092, Nov. 2009, [Peer-reviewed]
  English, Scientific journal
• Development of a reciprocating-wear testing machine under an ex vivo condition to evaluate the effect of artificial cartilage on articulating cartilage
  FUJIKI Hiroyuki; DAIMARUYA Masashi; KITAMURA Nobuto; KONDO Eiji; YASUDA Kazunori; CHEN Yong Mei; GONG Jian Ping; OSADA Yoshihito
  Japanese journal of clinical biomechanics, 30, 0, 63, 70, 日本臨床バイオメカニクス学会, 20 Sep. 2009
  Japanese
• 家兎膝関節骨軟骨欠損における高機能ダブルネットワークゲルを用いたin vivo軟骨自然再生誘導
  北村 信人; 新垣 和伸; 黒川 孝幸; Gong Jian Ping; 長田 義仁; 安田 和則
  日本整形外科学会雑誌, 83, 8, S1195, S1195, (公社)日本整形外科学会, Aug. 2009
  Japanese
• Electric field effect on the Sliding friction of a charged gel
  Masakazu Takata; Tetsuo Yamaguchi; Jian Ping Gong; Masao Doi
  Journal of the Physical Society of Japan, 78, 8, 084602-1, 081602-5, Aug. 2009, [Peer-reviewed]
  English, Scientific journal
• First Observation of Stick-Slip Instability in Tearing of Poly(vinyl alcohol) Gel Sheets
  Yoshimi Tanaka; Hiroyuki Abe; Takayuki Kurokawa; Hidemitsu Furukawa; Jian Ping Gong
  MACROMOLECULES, 42, 15, 5425, 5426, Aug. 2009, [Peer-reviewed]
  English, Scientific journal
• Nano-biomachine from actin and myosin gels
  Yoshihito Osada; Jian Ping Gong
  POLYMER SCIENCE SERIES A, 51, 6, 689, 700, Jun. 2009, [Invited]
  English, Scientific journal
• Direct Observation of Damage Zone around Crack Tips in Double-Network Gels
  Qiu Ming Yu; Yoshimi Tanaka; Hidemitsu Furukawa; Takayuki Kurokawa; Jian Ping Gong
  MACROMOLECULES, 42, 12, 3852, 3855, Jun. 2009, [Peer-reviewed]
  English, Scientific journal
• 高強度ＤＮゲルの開発と関節軟骨再生誘導への応用
  中島 祐; 龔 剣萍; 安田和則
  工業材料, 57, 6, 38, 41, May 2009, [Invited]
  Japanese, Scientific journal
• Double Network Hydrogel with High Modulus and Toughness : A Novel Material for Load-Bearing Soft Tissues
  GONG Jian Ping
  高分子, 58, 5, 327, 331, 高分子学会, May 2009, [Invited]
  Japanese, Scientific journal
• Photoinduced in situ formation of various F-actin assemblies with a photoresponsive polycation
  Manami Misu; Hidemitsu Furukawa; Hyuck-Joon Kwon; Kazuhiro Shikinaka; Akira Kakugo; Toshifumi Satoh; Yoshihito Osada; Jian Ping Gong
  JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 89A, 2, 424, 431, May 2009, [Peer-reviewed]
  English, Scientific journal
• A Novel Double-Network Hydrogel Induces Spontaneous Articular Cartilage Regeneration in vivo in a Large Osteochondral Defect
  Kazunori Yasuda; Nobuto Kitamura; Jian Ping Gong; Kazunobu Arakaki; Hyuck Joon Kwon; Shin Onodera; Yong Mei Chen; Takayuki Kurokawa; Fuminori Kanaya; Yoshihiro Ohmiya; Yoshihito Osada
  MACROMOLECULAR BIOSCIENCE, 9, 4, 307, 316, Apr. 2009, [Peer-reviewed]
  English, Scientific journal
• True Chemical Structure of Double Network Hydrogels
  Tasuku Nakajima; Hidemitsu Furukawa; Yoshimi Tanaka; Takayuki Kurokawa; Yoshihito Osada; Jian Ping Gong
  MACROMOLECULES, 42, 6, 2184, 2189, Mar. 2009, [Peer-reviewed]
  English, Scientific journal
• Mechanism on Polarity Sorting of Actin Bundles Formed with Polycations
  Kazuhiro Shikinaka; Akira Kakugo; Yoshihito Osada; Han Ping Gong
  LANGMUIR, 25, 3, 1554, 1557, Feb. 2009, [Peer-reviewed]
  English, Scientific journal
• Dynamics in Multicomponent Polyelectrolyte Solutions
  Sanghun Lee; Vijay R. Tirumala; Michihiro Nagao; Taiki Tominaga; Eric K. Lin; Jian Ping Gong; Wen-li Wu
  MACROMOLECULES, 42, 4, 1293, 1299, Feb. 2009, [Peer-reviewed]
  English, Scientific journal
• Adhesion, Spreading, and Proliferation of Endothelial Cells on Charged Hydrogels
  Yong Mei Chen; Jing Jing Yang; Jian Ping Gong
  JOURNAL OF ADHESION, 85, 11, 839, 868, 2009, [Peer-reviewed], [Invited]
  English, Scientific journal
• SUPER TOUGH GELS WITH A DOUBLE NETWORK STRUCTURE
  Tasuku Nakajima; Takayuki Kurokawa; Hidemitsu Furukawa; Qiu Ming Yu; Yoshimi Tanaka; Yoshihito Osada; Jian Ping Gong
  CHINESE JOURNAL OF POLYMER SCIENCE, 27, 1, 1, 9, Jan. 2009, [Peer-reviewed], [Invited]
  English, Scientific journal
• Ultrathin tough double network hydrogels showing adjustable muscle-like isometric force generation triggered by solvent
  Songmiao Liang; Qiu Ming Yu; Haiyan Yin; Zi Liang Wu; Takayuki Kurokawa; Jian Ping Gong
  CHEMICAL COMMUNICATIONS, 48, 7518, 7520, 2009, [Peer-reviewed]
  English, Scientific journal
• Brittle, ductile, paste-like behaviors and distinct necking of double network gels with enhanced heterogeneity
  Yasunori Kawauchi; Yoshimi Tanaka; Hidemitsu Furukawa; Takayuki Kurokawa; Tasuku Nakajima; Yoshihito Osada; Jian Ping Gong
  Journal of Physics: Conference Series, 184, 12016, (8pp), Institute of Physics Publishing, 2009, [Peer-reviewed], [Invited]
  English, International conference proceedings
• Orientated Bacterial Cellulose Culture Controlled by Liquid Substrate of Silicone Oil with Different Viscosity and Thickness
  Ananda Putra; Akira Kakugo; Hidemitsu Furukawa; Jian Ping Gong
  POLYMER JOURNAL, 41, 9, 764, 770, 2009, [Peer-reviewed]
  English, Scientific journal
• Antifouling properties of tough gels against barnacles in a long-term marine environment experiment
  T. Murosaki; T. Noguchi; K. Hashimoto; A. Kakugo; T. Kurokawa; J. Saito; Y. M. Chen; H. Furukawa; J. P. Gong
  BIOFOULING, 25, 7, 657, 666, 2009, [Peer-reviewed]
  English, Scientific journal
• Synthesis of Novel Double Network Hydrogels via Atom Transfer Radical Polymerization
  Xufeng Ni; Ananda Putra; Hidemitsu Furukawa; Jian Ping Gong
  COMPOSITE INTERFACES, 16, 4-6, 433, 446, 2009, [Peer-reviewed], [Invited]
  English, Scientific journal
• Nonvolatile and Shape-Memorized Bacterial Cellulose Gels Swollen by Poly(ethylene glycol)
  Yukari Numata; Kazumi Muromoto; Hidemitsu Furukawa; Jian Ping Gong; Kenji Tajima; Masanobu Munekata
  POLYMER JOURNAL, 41, 7, 524, 525, 2009, [Peer-reviewed]
  English, Scientific journal
• Friction between like-charged hydrogels-combined mechanisms of boundary, hydrated and elastohydrodynamic lubrication
  Shinsuke Oogaki; Go Kagata; Takayuki Kurokawa; Shinya Kuroda; Yoshihito Osada; Jian Ping Gong
  SOFT MATTER, 5, 9, 1879, 1887, 2009, [Peer-reviewed]
  English, Scientific journal
• Dynamic cell behavior on synthetic hydrogels with different charge densities
  Yong Mei Chen; Rie Ogawa; Akira Kakugo; Yoshihito Osada; Jian Ping Gong
  SOFT MATTER, 5, 9, 1804, 1811, 2009, [Peer-reviewed]
  English, Scientific journal
• Antifouling activity of synthetic polymer gels against cyprids of the barnacle (Balanus amphitrite) in vitro
  T. Murosaki; T. Noguchi; A. Kakugo; A. Putra; T. Kurokawa; H. Furukawa; Y. Osada; J. P. Gong; Y. Nogata; K. Matsumura; E. Yoshimura; N. Fusetani
  BIOFOULING, 25, 4, 313, 320, 2009, [Peer-reviewed]
  English, Scientific journal
• Tuning of cell proliferation on tough gels by critical charge effect
  Yong Mei Chen; Jian Ping Gong; Masaru Tanaka; Kazunori Yasuda; Sadaaki Yamamoto; Masatsugu Shimomura; Yoshihito Osada
  JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 88A, 1, 74, 83, Jan. 2009, [Peer-reviewed]
  English, Scientific journal
• Structural approaches on the toughness in double network hydrogels
  Taiki Tominaga; Yoshihito Osada; Jian Ping Gong
  NATO Science for Peace and Security Series A: Chemistry and Biology, 117, 138, 2009
  Scientific journal
• ４種類のダブルネットワークハイドロゲルの圧縮ひずみ速度依存特性−関節軟骨との比較−
  藤木裕行; 臺丸谷政志; 陳 咏梅; 龔 剣萍; 長田義仁; 安田和則
  日本臨床バイオメカニクス学会誌, 29, 261, 266, Dec. 2008
  Japanese, Scientific journal
• Highly Extensible Double-Network Gels with Self-Assembling Anisotropic Structure
  Wei Yang; Hidemitsu Furukawa; Jian Ping Gong
  ADVANCED MATERIALS, 20, 23, 4499, 4503, Dec. 2008, [Peer-reviewed]
  English, Scientific journal
• モータータンパク質でソフトアクチュエーター ―ナノからマクロへ―
  川村隆三; 龔剣萍
  未来材料, 8, 11, 58, 59, Nov. 2008, [Invited]
  Japanese, Scientific journal
• Friction properties of polymer gel with high mechanical strength
  島津英一郎; 江上正樹; 黒川孝幸; 龔剣萍
  NTN technical review, 76, 76, 45, 50, NTN, Oct. 2008
  Japanese, Scientific journal
• Tear Velocity Dependence of High-Strength Double Network Gels in Comparison with Fast and Slow Relaxation Modes Observed by Scanning Microscopic Light Scattering
  Hidemitsu Furukawa; Rikimaru Kuwabara; Yoshimi Tanaka; Takayuki Kurokawa; Yang-Ho Na; Yoshihito Osada; Jian Ping Gong
  MACROMOLECULES, 41, 19, 7173, 7178, Oct. 2008, [Peer-reviewed]
  English, Scientific journal
• Morphogenesis of Liposomes Caused by Polycation-Induced Actin Assembly Formation
  Haruka Maemichi; Kazuhiro Shikinaka; Akira Kakugo; Hidemitsu Furukawa; Yoshihito Osada; Han Ping Gong
  LANGMUIR, 24, 20, 11975, 11981, Oct. 2008, [Peer-reviewed]
  English, Scientific journal
• Integration of motor proteins - Towards an ATP fueled soft actuator
  Akira Kakugo; Kazuhiro Shikinaka; Jian Ping Gong
  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 9, 9, 1685, 1703, Sep. 2008, [Peer-reviewed], [Invited]
  English, Scientific journal
• Tough Hydrogel - Learn from Nature
  Hidemitsu Furukawa; Jian Ping Gong
  Advances in Science and Technology, 61, 40, 45, Sep. 2008, [Peer-reviewed], [Invited]
  English, Scientific journal
• Ring-shaped assembly of microtubules shows preferential counterclockwise motion
  Ryuzo Kawamura; Akira Kakugo; Kazuhiro Shikinaka; Yoshihito Osada; Jian Ping Gong
  BIOMACROMOLECULES, 9, 9, 2277, 2282, Sep. 2008, [Peer-reviewed]
  English, Scientific journal
• Localized yielding around crack tips of double-network gels(a)
  Yoshimi Tanaka; Yasunori Kawauchi; Takayuki Kurokawa; Hidemitsu Furukawa; Takaharu Okajima; Jian Ping Gong
  MACROMOLECULAR RAPID COMMUNICATIONS, 29, 18, 1514, 1520, Sep. 2008, [Peer-reviewed]
  English, Scientific journal
• Molecular model for toughening in double-network hydrogels
  Vijay R. Tirumala; Taiki Tominaga; Sanghun Lee; Paul D. Butler; Eric K. Lin; Jian Ping Gong; Wen-li Wu
  JOURNAL OF PHYSICAL CHEMISTRY B, 112, 27, 8024, 8031, Jul. 2008, [Peer-reviewed]
  English, Scientific journal
• Friction and Lubrication of Gels : Toward the Low Friction of Bio-tissue
  YASHIMA Shintaro; NAKANO Yukihiro; GONG Jian Ping
  Journal of Japanese Society of Biorheology, 22, 2, 10, 24, JAPANESE SOCIETY OF BIORHEOLOGY, Jun. 2008, [Invited]
  Japanese, Scientific journal, We have systematically studied the surface sliding friction of hydrogels, and various unique features in gel friction have been discovered. The frictional force and its dependencies on the load are quite different depending on the chemical structures of the gels, surface properties of the opposing substrates, and the measurement condition, which are completely different from those of solids. Most importantly, the friction coefficient of gels exhibits a value as low as 0.001, which cannot be obtained from the friction between two solid materials.
  Recently, we developed a general method to synthesize hydrogels with extremely low friction by introducing linear polymer brush on the surface of gels. Then, the frictional coefficient became μ=10^-4.
  However, conventional gels are mechanically too weak to be used as loading bearing materials. We recently developed anomalously strong gels by introducing a double network structure of the gel. These high strength hydrogels, containing 90 % water, sustain a compressive pressure as high as decades of MPa and show a high wear resistance due to their low friction. These gels might open new era of soft and wet materials for substituting articular cartilage and other tissues.
• Novel Oriented Bacterial Cellulose Gels on Oxygen-Permeable Substrates
  Ananda Putra; Hidemitsu Furukawa; Akira Kakugo; Jian Ping Gong
  Cellulose Communications, 15, 2, 73, 78, セルロ-ス学会, Jun. 2008, [Invited]
  English, Scientific journal
• 高強度・高機能ゲルの開発とその生体材料への応用
  陳咏梅; 龔剣萍
  ファインケミカル, 37, 6, 5, 14, May 2008, [Invited]
  Japanese, Scientific journal
• ＡＴＰ駆動型ソフトバイオマシンの創製
  角五 彰; グン剣萍; 長田義仁
  化学と工業, 61, 5, 510, 513, 日本化学会, 01 May 2008, [Invited]
  Japanese, Scientific journal
• Thermodynamic interactions in double-network hydrogels
  Taiki Tominaga; Vijay R. Tirumala; Sanghun Lee; Eric K. Lin; Jian Ping Gong; Wen-Li Wu
  JOURNAL OF PHYSICAL CHEMISTRY B, 112, 13, 3903, 3909, Apr. 2008, [Peer-reviewed]
  English, Scientific journal
• Tubular bacterial cellulose gel with oriented fibrils on the curved surface
  Ananda Putra; Akira Kakugo; Hidemitsu Furukawa; Jian P. Gong; Yoshihito Osada
  POLYMER, 49, 7, 1885, 1891, Apr. 2008, [Peer-reviewed]
  English, Scientific journal
• Self-assembling structure in solution of a semirigid polyelectrolyte
  Wei Yang; Hidemitsu Furukawa; Yukari Shigekura; Kazuhiro Shikinaka; Yoshihito Osada; Jian Ping Gong
  MACROMOLECULES, 41, 5, 1791, 1799, Mar. 2008, [Peer-reviewed]
  English, Scientific journal
• Biological responses of novel high-toughness double network hydrogels in muscle and the subcutaneous tissues
  Yoshie Tanabe; Kazunori Yasuda; Chinatsu Azuma; Hiroko Taniguro; Shin Onodera; Akira Suzuki; Yong Mei Chen; Jian Ping Gong; Yoshihito Osada
  JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 19, 3, 1379, 1387, Mar. 2008, [Peer-reviewed]
  English, Scientific journal
• Observation of the three-dimensional structure of actin bundles formed with polycations
  Kazuhiro Shikinaka; Hyuckjoon Kwon; Akira Kakugo; Hidemitsu Furukawa; Yoshihito Sada; Jian Ping Gong; Yoshitaka Aoyama; Hideo Nishioka; Hiroshi Jinnai; Takaharu Okajima
  BIOMACROMOLECULES, 9, 2, 537, 542, Feb. 2008, [Peer-reviewed]
  English, Scientific journal
• Flower Petal-like Pattern on Soft Hydrogels during Vodka Spreading
  Daisaku Kaneko; Hidemitsu Furukawa; Yoshirni Tanaka; Yoshihito Osada; Jian Ping Gong
  COLLOIDS FOR NANO- AND BIOTECHNOLOGY, 135, 225, +, 2008, [Peer-reviewed]
  English, International conference proceedings
• Interfacial water structure at polymer gel/quartz interfaces investigated by sum frequency generation spectroscopy
  Hidenori Noguchi; Minowa Hiroshi; Taiki Tominaga; Jian Ping Gong; Yoshihito Osada; Kohei Uosaki
  PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 10, 32, 4987, 4993, 2008, [Peer-reviewed]
  English, Scientific journal
• Friction of a soft hydrogel on rough solid substrates
  Taiki Tominaga; Takayuki Kurokawa; Hidemitsu Furukawa; Yoshihito Osada; Jian Ping Gong
  SOFT MATTER, 4, 8, 1645, 1652, 2008, [Peer-reviewed]
  English, Scientific journal
• Effect of substrate adhesion and hydrophobicity on hydrogel friction
  Taiki Tominaga; Naoyuki Takedomi; Hynek Biederman; Hidemitsu Furukawa; Yoshihito Osada; Jian Ping Gong
  SOFT MATTER, 4, 5, 1033, 1040, 2008, [Peer-reviewed]
  English, Scientific journal
• Production of bacterial cellulose with well oriented fibril on PDMS substrate
  Ananda Putra; Akira Kakugo; Hidentitsu Furukawa; Jian P. Gong; Yoshihito Osada; Tetsuya Uemura; Masafumi Yamamoto
  POLYMER JOURNAL, 40, 2, 137, 142, 2008, [Peer-reviewed]
  English, Scientific journal
• Integration of Biomolecular Motors: Toward an ATP Fueled Soft Moving System
  Kazuhiro Shikinaka; Ryuzo Kawamura; Akira Kakugo; Hidemitsu Furukawa; Jian Ping Gong; Yoshihito Osada
  Polymer Preprints, Japan, 57, 106, 2008
  English, Scientific journal
• The molecular origin of enhanced toughness in double-network hydrogels: A neutron scattering study
  Taiki Tominaga; Vijay R. Tirumala; Eric K. Lin; Jian Ping Gong; Hidemitsu Furukawa; Yoshihito Osada; Wen-li Wu
  POLYMER, 48, 26, 7449, 7454, Dec. 2007, [Peer-reviewed]
  English, Scientific journal
• Importance of entanglement between first and second components in high-strength double network gels
  Mei Huang; Hidemitsu Furukawa; Yoshimi Tanaka; Tasuku Nakajima; Yoshihito Osada; Jian Ping Gong
  MACROMOLECULES, 40, 18, 6658, 6664, Sep. 2007, [Peer-reviewed]
  English, Scientific journal
• Friction and Lubrication of Hydrogel
  KAKUGO Akira; GONG JianPing; OSADA Yoshihito
  Seibutsu Butsuri, 47, 4, 253, 258, The Biophysical Society of Japan General Incorporated Association, 26 Jul. 2007, [Invited]
  Japanese, Scientific journal
• Influence of cyclohexane vapor on stick-slip friction between mica surfaces
  Satomi Ohnishi; Daisaku Kaneko; Jian Ping Gong; Yoshihito Osada; A. M. Stewart; Vassili V. Yaminsky
  LANGMUIR, 23, 13, 7032, 7038, Jun. 2007, [Peer-reviewed]
  English, Scientific journal
• Friction of soft gel in dilute polymer solution
  Miao Du; Yasuyuki Maki; Taiki Tominaga; Hidemitsu Furukawa; Jian Ping Gong; Yoshihito Osada; Qiang Zheng
  MACROMOLECULES, 40, 12, 4313, 4321, Jun. 2007, [Peer-reviewed]
  English, Scientific journal
• Actin network formation by unidirectional polycation diffusion
  Hyuck Joon Kwon; Akira Kakugo; Takehiro Ura; Takaharu Okajima; Yoshimi Tanaka; Hidemitsu Furukawa; Yoshihito Osada; Jian Ping Gong
  LANGMUIR, 23, 11, 6257, 6262, May 2007, [Peer-reviewed]
  English, Scientific journal
• Biodegradation of high-toughness double network hydrogels as potential materials for artificial cartilage
  Chinatsu Azuma; Kazunori Yasuda; Yoshie Tanabe; Hiroko Taniguro; Fuminori Kanaya; Atsushi Nakayama; Yong Mei Chen; Jian Ping Gong; Yoshihito Osada
  JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 81A, 2, 373, 380, May 2007, [Peer-reviewed]
  English, Scientific journal
• Bacterial cellulose based hydrogel for articular soft tissues
  Akira Kakugo; Jian Ping Gong; Yoshihito Osada
  Cellulose Communications, 14, 2, 50, 54, セルロ-ス学会, Apr. 2007, [Invited]
  English, Scientific journal
• Friction coefficient between rubber and solid substrate - Effect of rubber thickness
  Daisaku Kaneko; Masaki Oshikawa; Tetsuo Yamaguchi; Jian Ping Gong; Masao Doi
  JOURNAL OF THE PHYSICAL SOCIETY OF JAPAN, 76, 4, 43601-1, 43601-3, Apr. 2007, [Peer-reviewed]
  English, Scientific journal
• Large strain hysteresis and mullins effect of tough double-network hydrogels
  Rebecca E. Webber; Costantino Creton; Hugh R. Brown; Jian Ping Gong
  MACROMOLECULES, 40, 8, 2919, 2927, Apr. 2007, [Peer-reviewed]
  English, Scientific journal
• Anisotropic gelation seeded by a rod-like polyelectrolyte
  Yukari Shigekura; Hidemitsu Furukawa; Wei Yang; Yong Mei Chen; Tatsuo Kaneko; Yoshihito Osada; Jian Ping Gong
  MACROMOLECULES, 40, 7, 2477, 2485, Apr. 2007, [Peer-reviewed]
  English, Scientific journal
• Platelet adhesion to human umbilical vein endothelial cells cultured on anionic hydrogel scaffolds
  Yong Mei Chen; Masaru Tanaka; Jian Ping Gong; Kazunori Yasuda; Sadaaki Yamamoto; Masatsugu Shimomura; Yoshihito Osada
  BIOMATERIALS, 28, 10, 1752, 1760, Apr. 2007, [Peer-reviewed]
  English, Scientific journal
• Surface sliding friction of negatively charged polyelectrolyte gels
  Go Kagata; Jian Ping Gong
  COLLOIDS AND SURFACES B-BIOINTERFACES, 56, 1-2, 296, 302, Apr. 2007, [Peer-reviewed]
  English, Scientific journal
• Motility and structural polymorphism of polymer-actin complex gel
  Hyuck Joon Kwon; Kazuhiro Shikinaka; Akira Kakugo; Hidemitsu Furukawa; Yoshihito Osada; Jian Ping Gong
  JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 7, 3, 844, 847, Mar. 2007, [Peer-reviewed]
  English, Scientific journal
• Selective cell spreading, proliferation, and orientation on micropatterned gel surfaces
  Yong Mei Chen; Kui Chuan Shen; Jian Ping Gong; Yoshihito Osada
  JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 7, 3, 773, 779, Mar. 2007, [Peer-reviewed]
  English, Scientific journal
• Anisotropic structure in gels induced by a little amount of rod-like polyelectrolyte
  古川英光; 重倉ゆかり; 長田義仁; 龔剣萍
  Journal of the Japanese Liquid Crystal Society, 11, 2, 153, 159, 日本液晶学会事務局, 2007, [Invited]
  Japanese, Scientific journal
• Growth and morphology of polymer-actin complexes
  Hyuck Joon Kwon; Kazuhiro Shikinaka; Akira Kakugo; Hidemitsu Furukawa; Yoshihito Osada; Jian Ping Gong
  CHINESE JOURNAL OF POLYMER SCIENCE, 25, 1, 47, 55, Jan. 2007, [Invited]
  English, Scientific journal
• Gel biomachine based on muscle proteins
  Hyuck Joon Kwon; Kazuhiro Shikinaka; Akira Kakugo; Jian Ping Gong; Yoshihito Osada
  POLYMER BULLETIN, 58, 1, 43, 52, Jan. 2007, [Peer-reviewed]
  English, Scientific journal
• 2P161 Dynamic self-assembly of microtubule complex by kinesin : toward ATP-fueled actuator(Molecular motors,Poster Presentations)
  Kawamura Ryuzo; Kakugo Akira; Furukawa Hidemitsu; Gong Jian Ping; Osada Yoshihito
  Seibutsu Butsuri, 47, S153, The Biophysical Society of Japan General Incorporated Association, 2007
  English
• Negatively charged polyelectrolyte gels as bio-tissue model system and for biomedical application
  Hyuck Joon Kwon; Jian Ping Gong
  CURRENT OPINION IN COLLOID & INTERFACE SCIENCE, 11, 6, 345, 350, Dec. 2006, [Invited]
  English, Scientific journal
• Anisotropic polyion-complex gels via template polymerization
  Yukari Shigekura; Hidemitsu Furukawa; Yongmei Chen; Yongmei Chen; Tatsuo Kaneko; Wei Yang; Jian Ping Gong; Jian Ping Gong; Yoshihito Osada
  Polymer Preprints, Japan, 55, 1754, 19 Oct. 2006
  We focus on highly-charged rigid-rod poly(2,2′-disulfonyl-4,4′- benzidine terephthalamide)(PBDT), which behaves as mesogen in water to induce lyotropic self-organization from a very low concentrations of 2.8wt.%. By template (matrix) polymerization of N-[3-(N,N-dimethylamino)propyl]acrylamide methyl chloride quarternary (DMAPAA-Q) with a very little amount of PBDT, the polyioncomplex gels that contains ordered network structure can be synthesized. In this study, scanning microscopic light scattering shows that PBDT and DMAPAA-Q aqueous solution forms some large structure before gelation, which may be related to the gelation induced orientation.
• Anisotropic nucleation growth of actin bundle: A model for determining the well-defined thickness of bundles
  Hyuck Joon Kwon; Yoshimi Tanaka; Akira Kakugo; Kazuhiro Shikinaka; Hidemitsu Furukawa; Yoshihito Osada; Jian Ping Gong
  BIOCHEMISTRY, 45, 34, 10313, 10318, Aug. 2006, [Peer-reviewed]
  English, Scientific journal
• Catch and release of DNA in coacervate-dispersed gels
  Asami Ohsugi; Hidemitsu Furukawa; Akira Kakugo; Yoshihito Osada; Jian Ping Gong
  MACROMOLECULAR RAPID COMMUNICATIONS, 27, 15, 1242, 1246, Aug. 2006, [Peer-reviewed]
  English, Scientific journal
• Surface friction of gellan gels
  Zhouting Jiang; Taiki Tominaga; Kosuke Kamata; Yoshihito Osada; Jian Ping Gong
  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 284, 56, 60, Aug. 2006, [Peer-reviewed]
  English, Scientific journal
• Necking phenomenon of double-network gels
  YH Na; Y Tanaka; Y Kawauchi; H Furukawa; T Sumiyoshi; JP Gong; Y Osada
  MACROMOLECULES, 39, 14, 4641, 4645, Jul. 2006, [Peer-reviewed]
  English, Scientific journal
• Self-assembly of rod-like polyelectrolytes in aqueous solution
  Wei Yang; Hidemitsu Furukawa; Yukari Shigekura; Jian Ping Gong; Yoshihito Osada
  Polymer Preprints, Japan, 55, 2, 3161, 3162, 2006
  Japanese, International conference proceedings
• Creation of hydrogels with ultra high mechanical strength [XII]: The effect of controlled void structure
  Tasuku Nakajima; Hidemitsu Furukawa; Yoshimi Tanaka; Takayuki Kurokawa; Jian Ping Gong; Yoshihito Osada
  Polymer Preprints, Japan, 55, 2, 3212, 3213, 2006
  Japanese, International conference proceedings
• Creation of hydrogels with ultra high mechanical strength [XIII]: The necking phenomenon in double network gels
  Yasunori Kawauchi; Rikimaru Kuwabara; Hidemitsu Furukawa; Yang-Ho Na; Yoshimi Tanaka; Takayuki Kurokawa; Jian Ping Gong; Yoshihito Osada
  Polymer Preprints, Japan, 55, 2, 3214, 3215, 2006
  Japanese, International conference proceedings
• Ultra-small-angle neutron scattering study of actin-polymer complexes formation
  Tomomi Masui; Kazuhiro Shikinaka; Hyuck Joon Kwon; Satoshi Koizumi; Takeji Hashimoto; Hiroki Iwash; Akira Kakugo; Jian Ping Gong
  Polymer Preprints, Japan, 55, 2, 3923, 3924, 2006
  Japanese, International conference proceedings
• Three dimensional structure observation of giant actin complexes by transmission electron microtomography
  Kazuhiro Shikinaka; Hyuckjoon Kwon; Akira Kakugo; Hidemitsu Furukawa; Jian Ping Gong; Yoshihito Osada; Hideo Nishioka; Hiroshi Jinnai
  Polymer Preprints, Japan, 55, 2, 3921, 3922, 2006
  Japanese, International conference proceedings
• Hydrated lubrication and friction of gels - Its richness and complexity
  Jian Ping Gong; Go Kagata; Takayuki Kurokawa; Yoshihito Osada
  Polymer Preprints, Japan, 55, 2, 4257, 4259, 2006
  Japanese, International conference proceedings
• Catch and release of DNA in coacervate-dispersed gels
  Asami Ohsugi; Hidemitsu Furukawa; Akira Kakugo; Jian Ping Gong; Yoshihito Osada
  Polymer Preprints, Japan, 55, 1, 1753, 2006
  Japanese, International conference proceedings
• Oriented bacterial cellulose gel produced in confined space
  Ananda Putra; Akira Kakugo; Hidemistu Furukawa; Jian Ping Gong; Yoshihito Osada
  Polymer Preprints, Japan, 55, 1, 1846, 2006
  English, International conference proceedings
• Spatio-temporal control of actin self-organization by photo responsive polymer
  Manami Misu; Hyuck-Joon Kwon; Kazuhiro Shikinaka; Akira Kakugo; Hidemitsu Furukawa; Jian Ping Gong; Yoshihito Osada; Toshifumi Satoh
  Polymer Preprints, Japan, 55, 1, 1848, 2006
  Japanese, International conference proceedings
• Gel-gel adhesion by double network structure
  Junji Saito; Rikimaru Kuwabara; Yoshimi Tanaka; Hidemitsu Furukawa; Jian Ping Gong; Yoshihito Osada
  Polymer Preprints, Japan, 55, 1, 1052, 2006
  Japanese, International conference proceedings
• The surface friction of hydrogel (26) - Effect of gel stiffness on the elastic-hydrodynamic transition
  Miao Du; Naoyuki Takedomi; Taki Tominaga; Hidemitsu Furukawa; Jian Ping Gong; Yoshihito Osada
  Polymer Preprints, Japan, 55, 1, 1120, 2006
  English, International conference proceedings
• 高分子ゲルの超低摩擦
  龔剣萍
  トライボロジスト, 51, 12, 867, 872, 2006, [Invited]
  Japanese, Scientific journal
• うなぎに学んだ超低摩擦ゲル
  武富直之; 龔剣萍
  接着の技術, 26, 3, 43, 48, 2006, [Invited]
  Japanese, Scientific journal
• Hydrogels with Extremely High Mechanical Strength
  SAITO Junji; GONG Jian Ping; OSADA Yoshihito
  MEMBRANE, 31, 6, 302, 306, THE MEMBRANE SOCIETY OF JAPAN, 2006, [Invited]
  Japanese, Scientific journal
• ナノテクノロジーによる人工軟骨の創成
  室崎喬之; 龔剣萍; 長田義仁
  日本臨牀, 64, 2, 206, 214, 2006, [Invited]
  Japanese, Scientific journal
• Polyelectrolyte gels-fundamentals and applications
  Hyuck Joon Kwon; Yoshihito Osada; Jian Ping Gong
  POLYMER JOURNAL, 38, 12, 1211, 1219, 2006, [Invited]
  English, Scientific journal
• Friction and lubrication of hydrogels - its richness and complexity
  Jian Ping Gong
  SOFT MATTER, 2, 7, 544, 552, 2006, [Peer-reviewed], [Invited]
  English, Scientific journal
• Surface properties of endothelial cells cultured on hydrogels
  Chen Y.M; Tanaka M; Gong J.P; Kazunori Y; Yamamoto S; Shimomura M; Osada Y
  Polymer Preprints, Japan, 55, 2, 4860, 2006, [Peer-reviewed]
• Superlow friction of polymer gel
  Jian Ping Gong
  JOURNAL OF JAPANESE SOCIETY OF TRIBOLOGISTS, 51, 12, 867, 872, 2006, [Peer-reviewed]
  Japanese, Scientific journal
• Polyioncomplex gels with liquid crystal structure
  Yukari Shigekura; Yongmei Chen; Yongmei Chen; Daisaku Kaneko; Hidemitsu Furukawa; Jian Ping Gong; Jian Ping Gong; Yoshihito Osada; Yoshihito Osada; Tatsuo Kaneko
  Polymer Preprints, Japan, 54, 1525, 01 Dec. 2005
  We study a novel kind of polyioncomplex gels with liquid crystalline structure. We focus on highly-charged rigid-rod poly(2,2′-disulfonyl-4, 4′-benzidine terephthalamide)(PBDT), which behaves as mesogen in water to induce lyotropic self-organization from a very low concentrations of 2.8wt.%. By template (matrix) polymerization with N-[3-(N,N-dimethylamino)propyl] acrylamide, methyl chloride quarternary (DMAPAA-Q) under the condition where the charge ratio of PBDT as a liquid crystal molecule to DMAPAA-Q as a monomer is 1:26, the gels exhibit strong birefringence. Here, the PBDT concentration in the gels is 1/20 of lower critical PBDT concentration in aqueous solution. It means that by adding a very little amount of ionic mesogen template the birefringence polyioncomplex gels that contains ordered network structure can be synthesized.
• Morphology of actin assemblies in response to polycation and salts
  HJ Kwon; A Kakugo; K Shikinaka; Y Osada; JP Gong
  BIOMACROMOLECULES, 6, 6, 3005, 3009, Nov. 2005, [Peer-reviewed]
  English, Scientific journal
• Anisotropic polyion-complex gels via template polymerization
  Y Shigekura; YM Chen; H Furukawa; T Kaneko; D Kaneko; Y Osada; JP Gong
  ADVANCED MATERIALS, 17, 22, 2695, +, Nov. 2005, [Peer-reviewed]
  English, Scientific journal
• Effect of polymer entanglement on the toughening of double network hydrogels
  H Tsukeshiba; M Huang; YH Na; T Kurokawa; R Kuwabara; Y Tanaka; H Furukawa; Y Osada; JP Gong
  JOURNAL OF PHYSICAL CHEMISTRY B, 109, 34, 16304, 16309, Sep. 2005, [Peer-reviewed]
  English, Scientific journal
• Elastic-hydrodynamic transition of gel friction
  T Kurokawa; T Tominaga; Y Katsuyama; R Kuwabara; H Furukawa; Y Osada; JP Gong
  LANGMUIR, 21, 19, 8643, 8648, Sep. 2005, [Peer-reviewed]
  English, Scientific journal
• Gel machines constructed from chemically cross-linked actins and myosins
  A Kakugo; K Shikinaka; JP Gong; Y Osada
  POLYMER, 46, 18, 7759, 7770, Aug. 2005, [Peer-reviewed]
  English, Scientific journal
• Cultivation of endothelial cells on adhesive protein-free synthetic polymer gels
  YM Chen; N Shiraishi; H Satokawa; A Kakugo; T Narita; JP Gong; Y Osada; K Yamamoto; J Ando
  BIOMATERIALS, 26, 22, 4588, 4596, Aug. 2005, [Peer-reviewed]
  English, Scientific journal
• Biomechanical properties of high-toughness double network hydrogels
  K Yasuda; JP Gong; Y Katsuyama; A Nakayama; Y Tanabe; E Kondo; M Ueno; Y Osada
  BIOMATERIALS, 26, 21, 4468, 4475, Jul. 2005, [Peer-reviewed]
  English, Scientific journal
• Determination of fracture energy of high strength double network hydrogels
  Y Tanaka; R Kuwabara; YH Na; T Kurokawa; JP Gong; Y Osada
  JOURNAL OF PHYSICAL CHEMISTRY B, 109, 23, 11559, 11562, Jun. 2005, [Peer-reviewed]
  English, Scientific journal
• Polarity and motility of large polymer-actin complexes
  A Kakugo; K Shikinaka; N Takekawa; S Sugimoto; Y Osada; JP Gong
  BIOMACROMOLECULES, 6, 2, 845, 849, Mar. 2005, [Peer-reviewed]
  English, Scientific journal
• Kinetics of fluid spreading on viscoelastic substrates
  D Kaneko; JP Gong; M Zrinyl; Y Osada
  JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS, 43, 5, 562, 572, Mar. 2005, [Peer-reviewed]
  English, Scientific journal
• Mechanically strong hydrogels with ultra-low frictional coefficients
  D Kaneko; T Tada; T Kurokawa; JP Gong; Y Osada
  ADVANCED MATERIALS, 17, 5, 535, +, Mar. 2005, [Peer-reviewed]
  English, Scientific journal
• Nano-gel machine reconstructed from muscle proteins
  Kazuhiro Shikinaka; Akira Kakugo; Jian Ping Gong; Yoshihito Osada
  e-Journal of Surface Science and Nanotechnology, 3, 51, 54, 14 Feb. 2005
  English, Scientific journal
• Toughening of hydrogels with double network structure
  Yang-Ho Na; Yoshinori Katsuyama; Rikimaru Kuwabara; Takayuki Kurokawa; Yoshihito Osada; Mitsuhiro Shibayama; Jian Ping Gong
  e-Journal of Surface Science and Nanotechnology, 3, 8, 11, 08 Jan. 2005
  English, International conference proceedings
• Creation of nano-biomachine with muscle proteins [12] motility assay of myosin coated beads on actin gel sheet built by polymer interaction
  Kazuhiro Shikinaka; Akira Kakugo; Hidemitsu Furukawa; Jian Ping Gong; Yoshihito Osada
  Polymer Preprints, Japan, 54, 1, 1532, 2005
  Japanese, International conference proceedings
• Three dimensional actin network formed by synthetic polycation(3) Major factors to determine longitudinal and lateral growth of actin complex
  Hyuckjoon Kwon; Akira Kakugo; Hidemitsu Furukawa; Jian Ping Gong; Yoshihito Osada
  Polymer Preprints, Japan, 54, 1, 1531, 2005
  Japanese, International conference proceedings
• Actin polymerization in confined spatial
  Takehiro Ura; Akira Kakugo; Hidemitsu Furukawa; Jian Ping Gong; Yoshihito Osada
  Polymer Preprints, Japan, 54, 1, 1530, 2005
  Japanese, International conference proceedings
• The toughening mechanism of double-network gels and structural inhomogeneity of 1st network
  Rikimaru Kuwabara; Hidemitsu Furukawa; Yang-Ho Na; Yasunori Kawauchi; Yoshimi Tanaka; Takayuki Kurokawa; Jian Ping Gong; Yoshihito Osada
  Polymer Preprints, Japan, 54, 1, 1307, 2005
  Japanese, International conference proceedings
• Creation of hydrogels with ultra high mechanical strength [XI]: Strength enhancement in double network gels by controlling inhomogeneous structure of 1st network gel
  Yasunori Kawauchi; Rikimaru Kuwabara; Hidemitsu Furukawa; Yang-Ho Na; Yoshimi Tanaka; Takayuki Kurokawa; Jian Ping Gong; Yoshihito Osada
  Polymer Preprints, Japan, 54, 2, 4688, 4689, 2005
  Japanese, International conference proceedings
• Creation of hydrogels with ultra high mechanical strength (X) -role of the 2nd network entanglement on the toughening of double network gels (X)
  Mei Huang; Rikimaru Kuwabara; Yang-Ho Na; Hiroyuki Tsukeshiba; Yoshimi Tanaka; Takayuki Kurokawa; Hidemitsu Furukawa; Jian Ping Gong; Yoshihito Osada
  Polymer Preprints, Japan, 54, 1, 868, 2005
  English, International conference proceedings
• Development of drag force measurement system in micro channel and effect of surface structure on hydrodynamics of microparticle
  Yuri Kishimoto; Akira Kakugo; Hidemitsu Furukawa; Jian Ping Gong; Yoshihito Osada; Junichi Hotta; Keiji Sasaki; Noboru Kitamura
  Polymer Preprints, Japan, 54, 2, 4668, 4669, 2005
  Japanese, International conference proceedings
• Cultivation of endothelial cells on polymer hydrogels (4) dynamic behavior of the cells on hydrogels
  Rie Ogawa; Yong Mei Chen; Akira Kakugo; Hidemitsu Furukawa; Jian Ping Gong; Yoshihito Osada
  Polymer Preprints, Japan, 54, 2, 4723, 4724, 2005
  Japanese, International conference proceedings
• ゲルの極低摩擦
  龔 剣萍; 長田義仁
  日本機械学会誌, 108, 1042, 28, 29, 2005, [Invited]
  Japanese, Scientific journal
• Tough Gel with Low Surface Friction
  GONG Jian Ping
  GOMU, 78, 4, 130, 134, THE SOCIRETY OF RUBBER SCIENCE AND TECHNOLOGYY, JAPAN, 2005, [Invited]
  Japanese, Scientific journal, The author's research group have systematically studied the surface sliding friction of hydrogels, and various unique features in gel friction have been discovered. The frictional force and its dependencies on the load are quite different depending on the chemical structures of the gels, surface properties of the opposing substrates, and the measurement condition, which are completely different from those of solids. Most importantly, the friction coefficient of gels exhibits a value as low as 0.001, which cannot be obtained from the friction between two solid materials.
  Therefore, gels have a high potential as a low friction material, such as an artificial cartilage. However, conventional gels are mechanically too weak to be used as load bearing materials. The author's research group recently developed a general method to obtain very strong gels by introducing a double network structure of the gel. These high strength hydrogels, containing 90% water, sustain a compressive pressure as high as decades of MPa and show a high wear resistance due to their extremely low friction. These gels might open new era of soft and wet materials for substituting articular cartilage and other tissues.
• Novel hydrogels with excellent mechanical performance
  Y Tanaka; JP Gong; Y Osada
  PROGRESS IN POLYMER SCIENCE, 30, 1, 1, 9, Jan. 2005, [Invited]
  English, Scientific journal
• 3P136 Structural polymorphism and growth of actin complex in polyelectrolyte system
  Kwon H.J.; Shikinaka M.; Kakugo A.; Hurukawa H.; Gong Jianping; Osada Y.
  Seibutsu Butsuri, 45, S237, The Biophysical Society of Japan General Incorporated Association, 2005
  Japanese
• Characteristics of chemically cross-linked myosin gels
  A Kakugo; S Sugimoto; K Shikinaka; JP Gong; Y Osada
  JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 16, 2, 203, 218, 2005, [Peer-reviewed]
  English, Scientific journal
• High mechanical strength double-network hydrogel with bacterial cellulose
  A Nakayama; A Kakugo; JP Gong; Y Osada; M Takai; T Erata; S Kawano
  ADVANCED FUNCTIONAL MATERIALS, 14, 11, 1124, 1128, Nov. 2004, [Peer-reviewed]
  English, Scientific journal
• Surface friction of poly(dimethyl siloxane) gel and its transition phenomenon
  Tomohiro Tada; Daisaku Kaneko; Jian Ping Gong; Tatsuo Kaneko; Yoshihito Osada
  Tribology Letters, 17, 3, 505, 511, Oct. 2004, [Peer-reviewed]
  English, Scientific journal
• Surface friction of hydrogels with well-defined polyelectrolyte brushes
  Y Ohsedo; R Takashina; JP Gong; Y Osada
  LANGMUIR, 20, 16, 6549, 6555, Aug. 2004, [Peer-reviewed]
  English, Scientific journal
• Structural characteristics of double network gels with extremely high mechanical strength
  YH Na; T Kurokawa; Y Katsuyama; H Tsukeshiba; JP Gong; Y Osada; S Okabe; T Karino; M Shibayama
  MACROMOLECULES, 37, 14, 5370, 5374, Jul. 2004, [Peer-reviewed]
  English, Scientific journal
• Shear-induced mesophase organization of polyanionic rigid rods in aqueous solution
  T Funaki; T Kaneko; K Yamaoka; Y Ohsedo; JP Gong; Y Osada; Y Shibasaki; M Ueda
  LANGMUIR, 20, 15, 6518, 6520, Jul. 2004, [Peer-reviewed]
  English, Scientific journal
• Thermoresponsive Shrinkage Triggered by Mesophase Transition in Liquid Crystalline Physical Hydrogels
  Tatsuo Kaneko; Kanji Yamaoka; Yoshihito Osada; Jian Ping Gong
  Macromolecules, 37, 14, 5385, 5388, Jun. 2004, [Peer-reviewed]
  English, Scientific journal
• Polymer gels (Reprinted from Functional Monomers and Polymers, pg 497-528, 1997)
  Y Osada; JP Gong; Y Tanaka
  JOURNAL OF MACROMOLECULAR SCIENCE-POLYMER REVIEWS, C44, 1, 87, 112, Feb. 2004, [Invited]
  English, Scientific journal
• Cooperative binding in surfactant–polymer association: A brief overview
  Rupali Gangopadhyay; Jian Ping Gong; Yoshihito Osada
  Reflexive Polymers and Hydrogels: Understanding and Designing Fast Responsive Polymeric Systems, 165, 188, CRC Press, 01 Jan. 2004
  English, In book
• 高強度低摩擦ソフトマテリアルの創製とその人工半月板への応用
  桑原力丸; 安田和則; 龔剣萍; 長田義仁
  医学のあゆみ, 221, 7, 771, 772, 2004, [Invited]
  Japanese, Scientific journal
• 1P168 Three-dimensional network formation by self-organization of actin on gel surface
  Ura T.; Kakugo A.; Gong Jian Ping; Osada Y.
  Seibutsu Butsuri, 44, S71, The Biophysical Society of Japan General Incorporated Association, 2004
  Japanese
• Liquid crystalline hydrogels: Mesomorphic behavior of amphiphilic polyacrylates bearing cholesterol mesogen
  T Kaneko; H Nagasawa; JP Gong; Y Osada
  MACROMOLECULES, 37, 1, 187, 191, Jan. 2004, [Peer-reviewed]
  English, Scientific journal
• Influence of shear stress on cationic surfactant uptake by anionic gels
  YM Chen; Y Katsuyama; JP Gong; Y Osada
  JOURNAL OF PHYSICAL CHEMISTRY B, 107, 49, 13601, 13607, Dec. 2003, [Peer-reviewed]
  English, Scientific journal
• Growth of large polymer-actin complexes
  A Kakugo; K Shikinaka; K Matsumoto; JP Gong; Y Osada
  BIOCONJUGATE CHEMISTRY, 14, 6, 1185, 1190, Nov. 2003, [Peer-reviewed]
  English, Scientific journal
• Effect of hydrophobic side chain on poly(carboxyl acid) dissociation and surfactant binding
  YM Chen; S Matsumoto; JP Gong; Y Osada
  MACROMOLECULES, 36, 23, 8830, 8835, Nov. 2003, [Peer-reviewed]
  English, Scientific journal
• Thickness decrease of a grafted polyelectrolyte membrane exposed to shear flow
  D Kaneko; T Narita; JP Gong; Y Osada; J Ando; K Yamamoto; S Ohnishi; VV Yaminsky
  JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS, 41, 22, 2808, 2815, Nov. 2003, [Peer-reviewed]
  English, Scientific journal
• Study on doping behaviors of vinyl hydrogels with pendant terthiophenes
  L Chen; JP Gong; Y Ohsedo; Y Osada
  MACROMOLECULAR CHEMISTRY AND PHYSICS, 204, 17, 2142, 2146, Nov. 2003, [Peer-reviewed]
  English, Scientific journal
• Formation of giant needle-like polycation-bile acid complexes
  T Kaneko; A Ichikawa; JP Gong; Y Osada
  MACROMOLECULAR RAPID COMMUNICATIONS, 24, 13, 789, 792, Sep. 2003, [Peer-reviewed]
  English, Scientific journal
• Liquid crystalline gels. 4. Water- and stress-induced mesophase transition
  K Yamaoka; T Kaneko; JP Gong; Y Osada
  LANGMUIR, 19, 20, 8134, 8136, Sep. 2003, [Peer-reviewed]
  English, Scientific journal
• Friction of gels. 7. Observation of static friction between like-charged gels
  G Kagata; JP Gong; Y Osada
  JOURNAL OF PHYSICAL CHEMISTRY B, 107, 37, 10221, 10225, Sep. 2003, [Peer-reviewed]
  English, Scientific journal
• Friction of Gels. 7. Observation of Static Friction Between Like-Charged Gels
  Go Kagata; Jian Ping Gong; Yoshihito Osada
  J. Phys. Chem. B, 107, 37, 10221, 10225, Aug. 2003, [Peer-reviewed]
  English, Scientific journal
• Double-network hydrogels with extremely high mechanical strength
  JP Gong; Y Katsuyama; T Kurokawa; Y Osada
  ADVANCED MATERIALS, 15, 14, 1155, +, Jul. 2003, [Peer-reviewed]
  English, Scientific journal
• Surface friction of polyelectrolyte gels
  Jian Ping Gong; Go Kagata; Yoshihito Osada
  Macromolecular Symposia, 195, 209, 216, Jun. 2003, [Invited]
  English, International conference proceedings
• Water-swollen hydrogels with pendant terthiophenes
  L Chen; JP Gong; Y Ohsedo; Y Osada
  MACROMOLECULAR CHEMISTRY AND PHYSICS, 204, 4, 661, 665, Mar. 2003, [Peer-reviewed]
  English, Scientific journal
• ソフトアンドウェットマター−ゲル−の摩擦
  富永大輝; 龔剣萍; 長田義仁
  表面, 40, 9, 317, 323, 2003, [Invited]
  Japanese, Scientific journal
• 筋肉タンパクによるゲルマシーンの創製
  角五彰; 龔剣萍; 長田義仁
  化学工業, 55, 4, 34, 42, 2003, [Invited]
  Japanese, Scientific journal
• 筋肉タンパクによるナノバイオマシーンの創製
  敷中一洋; 角五彰; 龔剣萍; 長田義仁
  Bio Medical Quick Review Net., 2003, [Invited]
  Japanese, Scientific journal
• Surface Friction of Polymer Gel
  GONG Jian Ping; OSADA Yoshihito
  Kobunshi, 52, 9, 711, 716, The Society of Polymer Science, Japan, 2003, [Invited]
  Japanese, Scientific journal
• Substrate effect on the formation of hydrogels with heterogeneous network structure
  P Mao; PG Jian; Y Osada
  CHEMICAL RECORD, 3, 1, 40, 50, 2003, [Invited]
  English, Scientific journal
• Substrate effect on topographical, elastic, and frictional properties of hydrogels
  T Kurokawa; JP Gong; Y Osada
  MACROMOLECULES, 35, 21, 8161, 8166, Oct. 2002, [Peer-reviewed]
  English, Scientific journal
• Polymer gels as soft and wet chemomechanical systems - an approach to artificial muscles
  D Kaneko; JP Gong; Y Osada
  JOURNAL OF MATERIALS CHEMISTRY, 12, 8, 2169, +, Aug. 2002, [Invited]
  English, Scientific journal
• Gel machines constructed from chemically cross-linked actins and myosins
  A Kakugo; S Sugimoto; JP Gong; Y Osada
  ADVANCED MATERIALS, 14, 16, 1124, 1126, Aug. 2002, [Peer-reviewed]
  English, Scientific journal
• Gel machines constructed from chemically cross-linked actins and myosins
  Akira Kakugo; Shin Sugimoto; Jian Ping Gong; Yoshihito Osada
  Advanced Materials, 14, 16, 1124, 1126, Aug. 2002, [Peer-reviewed]
• Inhibitory effects of hydrogels on the adhesion, germination, and development of zoospores originating from Laminaria angustata
  Yoshinori Katsuyama; Takayuki Kurokawa; Tatsuo Kaneko; Jian Ping Gong; Yoshihito Osada; Norishige Yotsukura; Taizo Motomura
  Macromolecular Chemistry and Physics, 203, 163, 169, 10 Jun. 2002
  The inhibition of germination and development of zoospores originating from Laminaria angustata originated on various kinds of hydrogels is studied. The effects of the water content of the gel (the degree of swelling), the electrical nature (neutral, positive charge, negative charge), the charge density, the counterions of hydrogels on the inhibition of zoospore germination and development of gametophytes are phenomenologically investigated. Among the gels investigated, poly(acrylic acid) (PAA) gel showed a dramatic inhibition to germination, and might serve as a novel, environmentally safe inhibitor of zoospore adhesion.
• Hydrogels with crystalline or liquid crystalline structure
  T Miyazaki; K Yamaoka; JP Gong; Y Osada
  MACROMOLECULAR RAPID COMMUNICATIONS, 23, 8, 447, 455, Jun. 2002, [Invited]
  English, Scientific journal
• Preparation of Molecularly Oriented Hydrogels and their Structures and Functions
  KANEKO Tatsuo; YAMAOKA Kanji; GONG Jian Ping; OSADA Yoshihito
  高分子学会予稿集, 51, 1, 53, 55, 10 May 2002
  Japanese
• Friction of gels. 6. Effects of sliding velocity and viscoelastic responses of the network
  Go Kagata; Jian Ping Gong; Yoshihito Osada
  Journal of Physical Chemistry B, 106, 18, 4596, 4601, 09 May 2002, [Peer-reviewed]
  English, Scientific journal
• Self-propagating association of zwitterionic polymers initiated by ionene polymers
  K Okawa; PP Gong; Y Osada
  MACROMOLECULAR RAPID COMMUNICATIONS, 23, 7, 423, 425, May 2002, [Peer-reviewed]
  English, Scientific journal
• Friction of gels. 6. Effects of sliding velocity and viscoelastic responses of the network
  G Kagata; JP Gong; Y Osada
  JOURNAL OF PHYSICAL CHEMISTRY B, 106, 18, 4596, 4601, May 2002, [Peer-reviewed]
  English, Scientific journal
• Effect of surface roughness of hydrophobic substrate on heterogeneous polymerization of hydrogels
  Mao Peng; Takayuki Kurokawa; Jian Ping Gong; Yoshihito Osada; Qiang Zheng
  Journal of Physical Chemistry B, 106, 12, 3073, 3081, 28 Mar. 2002, [Peer-reviewed]
  English, Scientific journal
• Gels stimulables (Intelligent gels)
  Hiroki Nagasawa; Jian Ping Gong; Yoshihito Osada
  Materiaux Adaptatifs, 251, 175, 181, Mar. 2002, [Peer-reviewed], [Invited]
  English, Scientific journal
• Surface friction of polymer gels
  JP Gong; Y Osada
  PROGRESS IN POLYMER SCIENCE, 27, 1, 3, 38, Feb. 2002, [Invited]
  English, Scientific journal
• Novel thermosensitive IPN hydrogel having a phase transition without volume change
  L Chen; JP Gong; Y Osada
  MACROMOLECULAR RAPID COMMUNICATIONS, 23, 3, 171, 174, Feb. 2002, [Peer-reviewed]
  English, Scientific journal
• Water-induced crystallization of hydrogels
  T Miyazaki; T Kaneko; JP Gong; Y Osada; M Demura; M Suzuki
  LANGMUIR, 18, 4, 965, 967, Feb. 2002, [Peer-reviewed]
  English, Scientific journal
• ゲルの機能からみた生体組織の役割
  附柴裕之; 龔剣萍; 長田義仁
  日本バイオレオロジー学会誌(B&R), 16, 2, 51, 60, 特定非営利活動法人 日本バイオレオロジー学会, 2002, [Invited]
  Japanese, Scientific journal
• Inhibitory effects of hydrogels on the adhesion, germination, and development of zoospores originating from Laminaria angustata
  Yoshinori Katsuyama; Takayuki Kurokawa; Tatsuo Kaneko; Jian Ping Gong; Yoshihito Osada; Norishige Yotsukura; Taizo Motomura
  Macromolecular Bioscience, 2, 4, 163, 169, 2002, [Peer-reviewed]
  English, Scientific journal
• Crystalline structure and thermal behavior of water-soluble copolymers with pendant terthiophenes
  L Chen; T Kaneko; JP Gong; Y Osada; Y Ohsedo; Y Shirota
  MACROMOLECULAR CHEMISTRY AND PHYSICS, 203, 1, 176, 181, Jan. 2002, [Peer-reviewed]
  English, Scientific journal
• Real-time laser sheet refraction to monitor in situ the heterogeneity of polymerization process on Teflon surface
  M. Peng; Jian Ping Gong; Y. Osada; X. Zhang; Q. Zheng
  Macromolecules, 34, 22, 7829, 7835, 23 Nov. 2001, [Peer-reviewed]
  English, Scientific journal
• Surface friction of polymer gels 2. Effect of charge
  G Kagata; JP Gong; Y Osada
  WEAR, 251, 1-12, 1188, 1192, Oct. 2001, [Peer-reviewed]
  English, Scientific journal
• Surface friction of polymer gels 1. Effect of interfacial interaction
  JP Gong; G Kagata; Y Iwasaki; Y Osada
  WEAR, 251, 1-12, 1183, 1187, Oct. 2001, [Peer-reviewed]
  English, Scientific journal
• Effects of carboxyls attached at alkyl side chain ends on the lamellar structure of hydrogels
  Takashi Miyazaki; Tatsuo Kaneko; Jian Ping Gong; Yoshihito Osada
  Macromolecules, 34, 17, 6024, 6028, 14 Aug. 2001, [Peer-reviewed]
  English, Scientific journal
• Microrheological investigation of substrate-induced gradient structure in hydrogels
  Tetsuharu Narita; Alexandra Knaebel; Jean-Pierre Munch; Sanveur Jean Candau; Jian Ping Gong; Yoshihito Osada
  Macromolecules, 34, 16, 5725, 5726, 31 Jul. 2001, [Peer-reviewed]
  English, Scientific journal
• Synthesis of hydrogels with extremely low surface friction
  JP Gong; T Kurokawa; T Narita; G Kagata; Y Osada; G Nishimura; M Kinjo
  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 123, 23, 5582, 5583, Jun. 2001, [Peer-reviewed]
  English, Scientific journal
• Heterogeneous polymerization of hydrogels on hydrophobic substrate
  Akishige Kii; Jian Xu; Jian Ping Gong; Yoshihito Osada; Xianmin Zhang
  Journal of Physical Chemistry B, 105, 20, 4565, 4571, 24 May 2001, [Peer-reviewed]
  English, Scientific journal
• A possible mechanism for the substrate effect on hydrogel formation
  JP Gong; A Kii; J Xu; Y Hattori; Y Osada
  JOURNAL OF PHYSICAL CHEMISTRY B, 105, 20, 4572, 4576, May 2001, [Peer-reviewed]
  English, Scientific journal
• Liquid crystalline gels. 3. Role of hydrogen bonding in the formation and stabilization of mesophase structures
  Kanji Yamaoka; Tatsuo Kaneko; Jian Ping Gong; Yoshihito Osada
  Macromolecules, 34, 5, 1470, 1476, ACS, 27 Feb. 2001, [Peer-reviewed]
  English, Scientific journal
• Kinetic study of cell disruption by ionic polymers with varied charge density
  T Narita; R Ohtakeyama; M Matsukata; JP Gong; Y Osada
  COLLOID AND POLYMER SCIENCE, 279, 2, 178, 183, Feb. 2001, [Peer-reviewed]
  English, Scientific journal
• Surface of Gel as the Extremely Low Friction Material
  KUROKAWA Takayuki; GONG Jian Ping; OSADA Yoshihito
  Oleoscience : Journal of Japan Oil Chemists' Society, 1, 9, 929, 934,926, 日本油化学会, 2001, [Invited]
  Japanese, Scientific journal
• 高分子ゲルの表面摩擦特性 ─超低摩擦特性の開発─
  大垣伸介; 龔剣萍; 長田義仁
  バイオサイエンスとインダストリー, 59, 12, 819, 824, 2001, [Invited]
  Japanese, Scientific journal
• ソフトアクチュエーター
  角五彰; 杉本信; 龔剣萍; 長田義仁
  表面技術, 52, 4, 317, 323, The Surface Finishing Society of Japan, 2001, [Invited]
  Japanese, Scientific journal
• ゲルの摩擦
  加々田剛; 龔剣萍; 長田義仁
  固体物理, 36, 2, 103, 111, アグネ技術センタ-, 2001, [Invited]
  Japanese, Scientific journal
• Shape memory functions and motility of amphiphilic polymer gels
  T Mitsumata; JP Gong; Y Osada
  POLYMERS FOR ADVANCED TECHNOLOGIES, 12, 1-2, 136, 150, Jan. 2001, [Invited]
  English, Scientific journal
• Spreading of liquids on gel surfaces
  D Szabo; S Akiyoshi; T Matsunaga; JP Gong; Y Osada; M Zrinyi
  JOURNAL OF CHEMICAL PHYSICS, 113, 18, 8253, 8259, Nov. 2000, [Peer-reviewed]
  English, Scientific journal
• Intelligent gel - Surface properties and functions of gels
  JP Gong; G Kagata; Y Osada
  MACROMOLECULAR SYMPOSIA, 159, 215, 220, Oct. 2000, [Invited]
  English, Scientific journal
• Ionization and order-disorder transition of hydrogels with ionizable hydrophobic side chain
  A Matsuda; Y Katayama; T Kaneko; JP Gong; Y Osada
  JOURNAL OF MOLECULAR STRUCTURE, 554, 1, 91, 97, Oct. 2000, [Peer-reviewed]
  English, Scientific journal
• Effect of charge on protein diffusion in hydrogels
  N Hirota; Y Kumaki; T Narita; JP Gong; Y Osada
  JOURNAL OF PHYSICAL CHEMISTRY B, 104, 42, 9898, 9903, Oct. 2000, [Peer-reviewed]
  English, Scientific journal
• Effects of charge density and hydrophobicity of ionene polymer on cell binding and viability
  T Narita; R Ohtakeyama; M Nishino; JP Gong; Y Osada
  COLLOID AND POLYMER SCIENCE, 278, 9, 884, 887, Sep. 2000, [Peer-reviewed]
  English, Scientific journal
• Effect of Aspect Ratio on Protein Diffusion in Hydrogels
  Jian Ping Gong; Naoki Hirota; Akira Kakugo; Tetsuharu Narita; Yoshihito Osada
  J. Phys. Chem. B, 104, 42, 9904, 9908, Sep. 2000, [Peer-reviewed]
  English, Scientific journal
• Liquid crystalline hydrogels. 2. Effects of water on the structural ordering
  Tatsuo Kaneko; Kanji Yamaoka; Jian Ping Gong; Yoshihito Osada
  Macromolecules, 33, 12, 4422, 4426, ACS, 13 Jun. 2000, [Peer-reviewed]
  English, Scientific journal
• Doping effects of water-soluble poly(3-thiopheneacetic acid) (P3TAA) and its gel
  BS Kim; L Chen; JP Gong; Y Osada
  KOREA POLYMER JOURNAL, 8, 3, 116, 119, Jun. 2000, [Peer-reviewed]
  English, Scientific journal
• Surface dynamic friction of polymer gels
  JP Gong; G Kagata; Y Iwasaki; Y Osada
  CHINESE JOURNAL OF POLYMER SCIENCE, 18, 3, 271, 275, May 2000, [Invited]
  English, Scientific journal
• Fluorinated water-swollen hydrogels with molecular and supramolecular organization
  Atsushi Matsuda; Tatsuo Kaneko; Jianping Gong; Yoshihito Osada
  Macromolecules, 33, 7, 2535, 2538, ACS, 04 Apr. 2000, [Peer-reviewed]
  English, Scientific journal
• Friction of Gels. 5. Negative Load Dependence of Polysaccharide Gels
  J. P. Gong; Y. Iwasaki; Y. Osada
  J. Phys. Chem. B, 104, 15, 3423, 3428, Mar. 2000, [Peer-reviewed]
  English, Scientific journal
• ゲル運動素子によるケミカルモーター
  龔剣萍; 長田義仁
  化学と工業, 53, 2, 184, 187, 2000, [Invited]
  Japanese, Scientific journal
• Surface Dynamic Friction of Polymer Gels
  P. Gong; Go Kagata; Y. Osada
  Reports on Progress in Polymer Physics in Japan, 43, 141, 162, 2000, [Invited]
  English, Scientific journal
• Hydrogels with the ordered structures
  T. Miyazaki; K. Yamaoka; T. Kaneko; J. P. Gong; Y. Osada
  SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS, 1, 4, 201, 210, 2000, [Invited]
  English, Scientific journal
• Substrate effects of gel surfaces on cell adhesion and disruption
  Tetsuharu Narita; Aki Hirai; Jian Xu; Jian Ping Gong; Yoshihito Osada
  Biomacromolecules, 1, 2, 162, 167, American Chemical Society, 2000, [Peer-reviewed]
  English, Scientific journal
• Effects of polyelectrolyte complexation on the UCST of zwitterionic polymer
  L. Chen; Y. Honma; T. Mizutani; D. J. Liaw; J. P. Gong; Y. Osada
  Polymer, 41, 1, 141, 147, Elsevier Science Ltd, Jan. 2000, [Peer-reviewed]
  English, Scientific journal
• Liquid-crystalline hydrogels. 1. Enhanced effects of incorporation of acrylic acid units on the liquid-crystalline ordering
  T Kaneko; K Yamaoka; JP Gong; Y Osada
  MACROMOLECULES, 33, 2, 412, 418, Jan. 2000, [Peer-reviewed]
  English, Scientific journal
• Environmental responses of polythiophene hydrogels
  Li Chen; ByoungSuhk Kim; Masahiko Nishino; Jian Ping Gong; Yoshihito Osada
  Macromolecules, 33, 4, 1232, 1236, ACS, 2000, [Peer-reviewed]
  English, Scientific journal
• Solution and electrical properties of the water-soluble poly(3-thiopheneacetic acid) and its hydrogel
  BS Kim; L Chen; JP Gong; Y Osada
  MOLECULAR CRYSTALS AND LIQUID CRYSTALS, 349, 335, 338, 2000, [Peer-reviewed]
  English, Scientific journal
• Chemomechanical bending behaviors of ionizable thin films with gradient network-size
  GB Park; Y Kagami; JP Gong; DC Lee; Y Osada
  THIN SOLID FILMS, 350, 1-2, 289, 294, Aug. 1999, [Peer-reviewed]
  English, Scientific journal
• Complexation and crystallization of anionic phthalocyanine with soluble and cross-linked polycations
  T Kaneko; S Orita; JP Gong; Y Osada
  LANGMUIR, 15, 17, 5670, 5675, Aug. 1999, [Peer-reviewed]
  English, Scientific journal
• Effects of counterions and co-ions on the surfactant binding process in the charged polymer network
  T Narita; N Hirota; JP Gong; Y Osada
  JOURNAL OF PHYSICAL CHEMISTRY B, 103, 30, 6262, 6266, Jul. 1999, [Peer-reviewed]
  English, Scientific journal
• Investigation of molecular diffusion in hydrogel by electronic speckle pattern interferometry
  XM Zhang; N Hirota; T Narita; JP Gong; Y Osada; KS Chen
  JOURNAL OF PHYSICAL CHEMISTRY B, 103, 29, 6069, 6074, Jul. 1999, [Peer-reviewed]
  English, Scientific journal
• Friction of gels. 4. Friction on charged gels
  JP Gong; G Kagata; Y Osada
  JOURNAL OF PHYSICAL CHEMISTRY B, 103, 29, 6007, 6014, Jul. 1999, [Peer-reviewed]
  English, Scientific journal
• Titration behavior and spectral transitions of water-soluble polythiophene carboxylic acids
  Byoungsuhk Kim; Li Chen; Jianping Gong; Yoshihito Osada
  Macromolecules, 32, 12, 3964, 3969, ACS, 15 Jun. 1999, [Peer-reviewed]
  English, Scientific journal
• Surface friction of hydrogels
  JP Gong; Y Iwasaki; G Kagata; Y Osada
  PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES, 75, 6, 122, 126, Jun. 1999, [Invited]
  English, Scientific journal
• Magnetism and compressive modulus of magnetic fluid containing gels
  T Mitsumata; K Ikeda; JP Gong; Y Osada; D Szabo; M Zrinyi
  JOURNAL OF APPLIED PHYSICS, 85, 12, 8451, 8455, Jun. 1999, [Peer-reviewed]
  English, Scientific journal
• Friction of Gels. 3. Friction on Solid Surfaces
  J. P. Gong; Y. Iwasaki; Y. Osada; K. Kurihara; Y. Hamai
  J. Phys. Chem. B, 103, 29, 6001, 6006, May 1999, [Peer-reviewed]
  English, Scientific journal
• Adsorption of bovine serum albumin to yeast protoplast
  M Matsukata; M Nishino; JP Gong; Y Osada; Y Sakurai; T Okano
  COLLOIDS AND SURFACES B-BIOINTERFACES, 13, 4, 203, 211, May 1999, [Peer-reviewed]
  English, Scientific journal
• In situ Monitoring of Hydrogel Polymerization Using Speckle Interferometry
  X. M. Zhang; J. Xu; K. Okawa; Y. Katsuyama; J. P. Gong; Y. Osada; K. S. Chen
  J. Phys. Chem. B, 103, 15, 2888, 2891, Mar. 1999, [Peer-reviewed]
  English, Scientific journal
• Molecular and supramolecular structures of complexes formed by polyelectrolyte-surfactant interactions: Effects of charge density and compositions
  BS Kim; M Ishizawa; JP Gong; Y Osada
  JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 37, 5, 635, 644, Mar. 1999, [Peer-reviewed]
  English, Scientific journal
• 双性イオン高分子と高分子電解質との相互作用によるUCST制御
  陳莉; 龔剣萍; 長田義仁
  高分子加工別冊, 48, 11, 500, 505, 高分子刊行会, 1999, [Invited]
  Japanese, Scientific journal
• Specific Surface Friction of Polymer Gels:Experimental Results and Theoretical Analysis
  KAGATA Go; GONG Jianping; OSADA Yoshihito
  Journal of Network Polymer,Japan, 20, 3, 130, 137, Japan Thermosetting Plastics Industry Association, 1999, [Invited]
  Japanese, Scientific journal, The sliding friction of various kinds of hydrogels has been studied. It was found that the frictional behaviors of the hydrogels did not conform to Amonton's law F=mW. The gel friction is explained in terms of interfacial interaction, either attractive or repulsive, between polymer chains and solid surfaces. According to this repulsion-adsorption model proposed by authors, the friction is ascribed, in the repulsive case, to the viscous flow of solvent at the interface; and in the attractive case, the force to detach the absorbing chain from the substrate.
• 生物はなぜ滑らかに動けるのか
  龔剣萍; 長田義仁
  科学, 69, 8, 672, 680, 岩波書店, 1999, [Invited]
  Japanese, Scientific journal
• 高分子ゲル-界面活性剤相互作用のダイナミックス
  成田哲治; 龔剣萍; 長田義仁
  高分子加工, 48, 6, 268, 274, 高分子刊行会, 1999, [Invited]
  Japanese, Scientific journal
• 秩序-無秩序転移するハイドロゲル─その形状記憶特性と運動特性─
  龔剣萍; 長田義仁
  機能材料, 19, 3, 5, 12, シ-エムシ-, 1999, [Invited]
  Japanese, Scientific journal
• Surfactant binding by polyelectrolyte gels and its application to electro-driven chemomechanics
  ByoungSuhk Kim; Jianping Gong; Yoshihito Osada
  Polymer International, 48, 8, 691, 698, John Wiley and Sons Ltd, 1999, [Invited]
  English, Scientific journal
• Soft and Wet Materials: Polymer Gels
  Y. Osada; J. P. Gong
  Advanced Materials, 10, 11, 827, 837, Jan. 1999, [Invited]
  English, Scientific journal
• Polymer-surfactant interactions: their cooperativity and stoichiometry
  N Isogai; T Narita; L Chen; M Hirata; JP Gong; Y Osada
  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 147, 1-2, 189, 201, Jan. 1999, [Peer-reviewed]
  English, Scientific journal
• Synthesis and properties of poly(3-thiopheneacetic acid) and its networks via electropolymerization
  DJ Liaw; BY Liaw; JP Gong; Y Osada
  SYNTHETIC METALS, 99, 1, 53, 59, Jan. 1999, [Peer-reviewed]
  English, Scientific journal
• Shape memory gels with multi-stimuli-responses
  Tatsuo Kaneko; Takashi Miyazaki; Kanji Yamaoka; Yuichi Katayama; Atsushi Matsuda; Jian Ping Gong; Yoshihito Osada
  Proceedings of SPIE - The International Society for Optical Engineering, 3669, 199, 208, 01 Jan. 1999
  The shape memory effect with multi stimuli responses of the hydrogels having the various type of long alkyl chains: poly (stearyl acrylate -co- acrylic acid) p(HA-co-AA), poly(16-acryloylhexadecanoic acid -co- acrylic acid) p(AHA-co-AA), poly(12-acryloyldodecanoic acid -co- acrylic acid) p(ADA-co-AA), and poly (stearyl acrylate -co- methyl acrylate) p(SA-co-MA) were investigated. P(SA-co-AA) gel exhibited the reversible order-disorder transition on heating at 49 °C and on cooling at 42 °C. The transition was derived from the melting of the hydrophobic domain formed by the long alkyl side chain. The Young's modulus decreased dramatically during the transition. Besides this gel showed the shape memory effect based on the order-disorder transition. The shape of deformed p(SA-co-AA) gel recovered very quickly (5s). In the p(SA-co-MA)gel system, the transition temperature could be varied. Moreover, p(AHA-co-AA) gel responded to not only temperature change but also change of pH and solvent composition.
• Gel friction: A model based on surface repulsion and adsorption
  J Gong; Y Osada
  JOURNAL OF CHEMICAL PHYSICS, 109, 18, 8062, 8068, Nov. 1998, [Peer-reviewed]
  English, Scientific journal
• Solvent-driven chemical motor
  T Mitsumata; K Ikeda; JP Gong; Y Osada
  APPLIED PHYSICS LETTERS, 73, 16, 2366, 2368, Oct. 1998, [Peer-reviewed]
  English, Scientific journal
• Low-Frequency Dielectric Relaxation of Polyelectrolyte Gels
  Tetsu Mitsumata; Jian Ping Gong; Kazuo Ikeda; Yoshihito Osada
  J. Phys. Chem. B, 102, 27, 5246, 5251, Jun. 1998, [Peer-reviewed]
  English, Scientific journal
• Kinetic Study of Surfactant Binding into Polymer Gel- Experimental and Theoretical Analyses
  Tetsu Mitsumata; Jian Ping Gong; Kazuo Ikeda; Yoshihito Osada
  J. Phys. Chem. B, 102, 23, 4566, 4572, May 1998, [Peer-reviewed]
  English, Scientific journal
• Effect of Water and Cross-linkage on the formation of Organized Structure in the Hydrogel
  Atsushi Matsuda; Jian Ping Gong; Yoshihito Osada
  Polymer Gels and Networks, 6, 5, 307, 317, Apr. 1998, [Peer-reviewed]
  English, Scientific journal
• Surfactant binding of polycations carrying charges on the chain backbone: Cooperativity, stoichiometry and crystallinity
  Li Chen; Shuyan Yu; Yoshiharu Kagami; Jianping Gong; Yoshihito Osada
  Macromolecules, 31, 3, 787, 794, American Chemical Society, 10 Feb. 1998, [Peer-reviewed]
  English, Scientific journal
• Polymer gels as a chemical valve
  M Nishino; JP Gong; Y Osada
  BIOSEPARATION, 7, 4-5, 269, 280, 1998, [Invited]
  English, Scientific journal
• Cooperative binding of surfactants with solubilized polymers and networks
  T Narita; JP Gong; Y Osada
  WILEY POLYMER NETWORKS GROUP REVIEW SERIES, VOL 1 - CHEMICAL AND PHYSICAL NETWORKS, 1, 477, 488, 1998, [Invited]
  English, International conference proceedings
• Two step surfactant binding of solvated and cross-linked poly(N-isopropylacrylamide-co-(2-acrylamido-2-methyl propane sulfonic acid))
  M Matsukata; M Hirata; JP Gong; Y Osada; Y Sakurai; T Okano
  COLLOID AND POLYMER SCIENCE, 276, 1, 11, 18, Jan. 1998, [Peer-reviewed]
  English, Scientific journal
• Enhanced velocity of surfactant binding after the volume collapse of an oppositely charged gel
  T Narita; JP Gong; Y Osada
  MACROMOLECULAR RAPID COMMUNICATIONS, 18, 9, 853, 857, Sep. 1997, [Peer-reviewed]
  English, Scientific journal
• Friction of gels
  JP Gong; M Higa; Y Iwasaki; Y Katsuyama; Y Osada
  JOURNAL OF PHYSICAL CHEMISTRY B, 101, 28, 5487, 5489, Jul. 1997, [Peer-reviewed]
  English, Scientific journal
• Chemomechanical polymer gel with fish-like motion
  Y Ueoka; J Gong; Y Osada
  JOURNAL OF INTELLIGENT MATERIAL SYSTEMS AND STRUCTURES, 8, 5, 465, 471, May 1997, [Peer-reviewed]
  English, Scientific journal
• Electrical conductance of polyelectrolyte gels
  JP Gong; N Komatsu; T Nitta; Y Osada
  JOURNAL OF PHYSICAL CHEMISTRY B, 101, 5, 740, 745, Jan. 1997, [Peer-reviewed]
  English, Scientific journal
• Formation of soluble complexes by two-step surfactant bindings
  SY Yu; M Hirata; L Chen; S Matsumoto; M Matsukata; JP Gong; Y Osada
  MACROMOLECULES, 29, 24, 8021, 8023, Nov. 1996, [Peer-reviewed]
  English, Scientific journal
• A comparative study on the cooperative binding of surfactants with solubilized polymers and networks
  JP Gong; T Mizutani; Y Osada
  POLYMERS FOR ADVANCED TECHNOLOGIES, 7, 10, 797, 804, Oct. 1996, [Peer-reviewed]
  English, Scientific journal
• Thermosensitive polymer gel by reversible surfactant binding
  N Isogai; JP Gong; Y Osada
  MACROMOLECULES, 29, 21, 6803, 6806, Oct. 1996, [Peer-reviewed]
  English, Scientific journal
• Shape memory behaviors of crosslinked copolymers containing stearyl acrylate
  Y Kagami; JP Gong; Y Osada
  MACROMOLECULAR RAPID COMMUNICATIONS, 17, 8, 539, 543, Aug. 1996, [Peer-reviewed]
  English, Scientific journal
• Motion of polymer gels by spreading organic fluid on water
  JP Gong; S Matsumoto; M Uchida; N Isogai; Y Osada
  JOURNAL OF PHYSICAL CHEMISTRY, 100, 26, 11092, 11097, Jun. 1996, [Peer-reviewed]
  English, Scientific journal
• Polymer gel: soft and wet intelligent material
  Yoshihito Osada; Y. Ueoka; J. P. Gong
  Proceedings of SPIE - The International Society for Optical Engineering, 2779, 344, 348, Society of Photo-Optical Instrumentation Engineers, 1996
  English, International conference proceedings
• MODELING AND SIMULATION OF ELECTROSTATIC POTENTIAL DISTRIBUTION IN POLYELECTROLYTE GELS
  JP GONG; Y OSADA
  ELECTROCHIMICA ACTA, 40, 13-14, 2445, 2447, Oct. 1995, [Peer-reviewed]
  English, Scientific journal
• SOFT AND WET TOUCH-SENSING SYSTEM MADE OF HYDROGEL
  K SAWAHATA; JP GONG; Y OSADA
  MACROMOLECULAR RAPID COMMUNICATIONS, 16, 10, 713, 716, Oct. 1995, [Peer-reviewed]
  English, Scientific journal
• THEORETICAL-ANALYSIS OF THE CROSS-LINKING EFFECT ON THE POLYELECTROLYTE-SURFACTANT INTERACTION
  JP GONG; Y OSADA
  JOURNAL OF PHYSICAL CHEMISTRY, 99, 27, 10971, 10975, Jul. 1995, [Peer-reviewed]
  English, Scientific journal
• PRESENCE OF ELECTROSTATIC POTENTIAL WELLS IN THE IONIC POLYMER NETWORK
  JP GONG; Y OSADA
  CHEMISTRY LETTERS, 6, 449, 450, Jun. 1995, [Peer-reviewed]
  English, Scientific journal
• SPONTANEOUS MOTION OF AMPHOTERIC POLYMER GELS ON WATER
  Y OSADA; JP GONG; M UCHIDA; N ISOGAI
  JAPANESE JOURNAL OF APPLIED PHYSICS PART 2-LETTERS, 34, 4B, L511, L512, Apr. 1995, [Peer-reviewed]
  English, Scientific journal
• ELECTROCONDUCTIVE ORGANOGEL .6. THERMAL AND ELECTROCONDUCTIVE CHARACTERISTICS OF A CHARGED POLYPEPTIDE GEL IN ORGANIC MEDIUM
  T NISHIDE; JP GONG; H YASUNAGA; N NISHI; Y OSADA
  MACROMOLECULES, 27, 26, 7877, 7879, Dec. 1994, [Peer-reviewed]
  English, Scientific journal
• ELECTROKINETIC MODELING OF THE CONTRACTILE PHENOMENA OF POLYELECTROLYTE GELS - ONE-DIMENSIONAL CAPILLARY MODEL
  JP GONG; T NITTA; Y OSADA
  JOURNAL OF PHYSICAL CHEMISTRY, 98, 38, 9583, 9587, Sep. 1994, [Peer-reviewed]
  English, Scientific journal
• INVESTIGATION OF PRECIPITATE FORMATION ON LASER-ABLATED YBA2CU3O7-DELTA THIN-FILMS
  JP GONG; M KAWASAKI; K FUJITO; R TSUCHIYA; M YOSHIMOTO; H KOINUMA
  PHYSICAL REVIEW B, 50, 5, 3280, 3287, Aug. 1994, [Peer-reviewed]
  English, Scientific journal
• CRYOGENIC SCANNING-TUNNELING-MICROSCOPY SPECTROSCOPY ON THE (001) SURFACES OF YBA2CU3OY EPITAXIAL THIN-FILMS
  M NANTOH; T HASEGAWA; W YAMAGUCHI; A TAKAGI; M OGINO; K KITAZAWA; M KAWASAKI; JP GONG; H KOINUMA
  JOURNAL OF APPLIED PHYSICS, 75, 10, 5227, 5232, May 1994, [Peer-reviewed]
  English, Scientific journal
• CRYOGENIC STM STS OBSERVATION ON OXIDE SUPERCONDUCTORS
  M NANTOH; T HASEGAWA; M KAWASAKI; JP GONG; K FUJITO; A TAKAGI; W YAMAGUCHI; M OGINO; H KOINUMA; K KITAZAWA
  JOURNAL OF SUPERCONDUCTIVITY, 7, 2, 349, 353, Apr. 1994, [Peer-reviewed]
  English, Scientific journal
• ソフト＆ウェットマテリアル―ゲル
  グン剣萍; 長田義仁
  固体物理, 30, 11, 982, 989, 1994, [Invited]
  Japanese, Scientific journal
• Electro-Driven Gel Actuator
  Y. Osada; H. Okuzaki; J. P. Gong
  Trends in Polym. Sci, 2, 61, 66, 1994, [Invited]
  English, Scientific journal
• Electro-Driven Gel Motility on the Base of Cooperative Molecular Assembly Reaction
  Y. Osada; H. Okuzaki; J. P. Gong; T. Nitta
  Polym. Sci, 36, 340, 351, 1994, [Invited]
  English, Scientific journal
• Photo-Current Characteristics of Two-Layered Organic Thin Films Prepared by Plasma Polymerization
  Jianping Gong; Satomi Ohnishi; Yoshihito Osada
  Polymer Journal, 26, 6, 754, 757, 1994, [Peer-reviewed]
  English, Scientific journal
• ELECTRICAL CONTROL OF POLYMER ASSOCIATION AND ITS CHEMOMECHANICAL BEHAVIOR
  S MAEKAWA; JP GONG; Y OSADA
  MACROMOLECULAR RAPID COMMUNICATIONS, 15, 1, 73, 79, Jan. 1994, [Peer-reviewed]
  English, Scientific journal
• Photo-Current Characteristics of Two-Layered Organic Thin Films Prepared by Plasma Polymerization
  Jianping Gong; Satomi Ohnishi; Yoshihito Osada
  Polymer Journal, 26, 6, 754, 757, 1994, [Peer-reviewed]
  English, Scientific journal
• Electrical Control of Polymer Association and Its Chemomechanical Behaviors
  S. Maekawa; J. P. Gong; Y. Osada
  Macromol. Rapid Commun., 15, 1, 73, 79, Jan. 1994, [Peer-reviewed]
  English, Scientific journal
• Iridescent coloration of a copolymer gel in an organic solvent
  Jianping Gong; Hidenori Okuzaki; Yoshihito Osada
  Macromolecular Chemistry and Physics, 195, 5, 1871, 1876, 1994, [Peer-reviewed]
  English, Scientific journal
• SUPPRESSION OF PRECIPITATE FORMATION IN HETEROEPITAXIAL GROWTH OF YBA2CU3O7-DELTA FILM ON MISORIENTED SRTIO3 SUBSTRATES
  JP GONG; M KAWASAKI; K FUJITO; R TSUCHIYA; M YOSHIMOTO; H KOINUMA
  JAPANESE JOURNAL OF APPLIED PHYSICS PART 2-LETTERS, 33, 1A, L20, L23, Jan. 1994, [Peer-reviewed]
  English, Scientific journal
• SURFACE AND INTERFACE CHARACTERIZATION OF HIGH-T(C) RELATED EPITAXIAL-FILMS BY STM/STS AND XPS
  H KOINUMA; S GONDA; JP GONG; M KAWASAKI; M YOSHIMOTO; M NANTOH; T HASEGAWA; K KITAZAWA
  JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS, 54, 10, 1215, 1218, Oct. 1993, [Peer-reviewed]
  English, Scientific journal
• HETEROEPITAXIAL GROWTH OF C-AXIS-ORIENTED BATIO3 THIN-FILMS WITH AN ATOMICALLY SMOOTH SURFACE
  JP GONG; M KAWASAKI; K FUJITO; U TANAKA; N ISHIZAWA; M YOSHIMOTO; H KOINUMA; M KUMAGAI; K HIRAI; K HORIGUCHI
  JAPANESE JOURNAL OF APPLIED PHYSICS PART 2-LETTERS, 32, 5A, L687, L689, May 1993, [Peer-reviewed]
  English, Scientific journal
• PREPARATION AND NANOSCALE CHARACTERIZATION OF HIGHLY STABLE YBA2CU3O7-DELTA THIN-FILMS
  M KAWASAKI; JP GONG; M NANTOH; T HASEGAWA; K KITAZAWA; M KUMAGAI; K HIRAI; K HORIGUCHI; M YOSHIMOTO; H KOINUMA
  JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS SHORT NOTES & REVIEW PAPERS, 32, 4, 1612, 1616, Apr. 1993, [Peer-reviewed]
  English, Scientific journal
• STIMULI-RESPONSIVE POLYMER GELS AND THEIR APPLICATION TO CHEMOMECHANICAL SYSTEMS
  Y OSADA; JP GONG
  PROGRESS IN POLYMER SCIENCE, 18, 2, 187, 226, 1993, [Peer-reviewed], [Invited]
  English, Scientific journal
• PREPARATION OF POLYMERIC METAL-TETRACYANOQUINODIMETHANE FILM AND ITS BISTABLE SWITCHING
  JP GONG; Y OSADA
  APPLIED PHYSICS LETTERS, 61, 23, 2787, 2789, Dec. 1992, [Peer-reviewed]
  English, Scientific journal
• ELECTROCONDUCTIVE ORGANOGEL .4. ELECTRODRIVEN CHEMOMECHANICAL BEHAVIORS OF CHARGE-TRANSFER COMPLEX GEL IN ORGANIC-SOLVENT
  JP GONG; KAWAKAMI, I; Y OSADA
  MACROMOLECULES, 24, 25, 6582, 6587, Dec. 1991, [Peer-reviewed]
  English, Scientific journal
• FABRICATION OF CERAMICS HETEROJUNCTIONS AND LAYERED CUPRATES BY EPITAXIAL LAYER-BY-LAYER GROWTH
  M YOSHIMOTO; H NAGATA; S GONDA; JP GONG; H OHKUBO; H KOINUMA
  PHYSICA C, 190, 1-2, 43, 45, Dec. 1991, [Peer-reviewed]
  English, Scientific journal
• LASER MBE OF LAYERED [(AE)2+/(CUO2)2-]N (AE = SR OR BA) LATTICES
  M YOSHIMOTO; H NAGATA; JP GONG; H OHKUBO; H KOINUMA
  PHYSICA C, 185, Pt 3, 2085, 2086, Dec. 1991, [Peer-reviewed]
  English, Scientific journal
• ELECTROCONDUCTIVE ORGANOGEL .3. PREPARATION AND PROPERTIES OF A CHARGE-TRANSFER COMPLEX GEL IN AN ORGANIC-SOLVENT
  JP GONG; KAWAKAMI, I; VG SERGEYEV; Y OSADA
  MACROMOLECULES, 24, 19, 5246, 5250, Sep. 1991, [Peer-reviewed]
  English, Scientific journal
• SYNTHESIS, MECHANISM, AND APPLICATION OF AN ELECTRO-DRIVEN CHEMOMECHANICAL SYSTEM USING POLYMER GELS
  Y OSADA; JP GONG; K SAWAHATA
  JOURNAL OF MACROMOLECULAR SCIENCE-CHEMISTRY, A28, 11-12, 1189, 1205, 1991, [Invited]
  English, Scientific journal
• FRACTAL PATTERN-FORMATION OF METAL-CONTAINING POLYMERIC THIN-FILMS PREPARED BY PLASMA REACTION
  J GONG; Y KAGAMI; K YAMADA; Y OSADA
  BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 63, 6, 1578, 1583, Jun. 1990, [Peer-reviewed]
  English, Scientific journal
• PREPARATION, STRUCTURE AND ELECTRIC PROPERTIES OF PLASMA-POLYMERIZED METAL-CONTAINING ORGANIC THIN-FILMS
  Y KAGAMI; K YAMADA; T YAMAUCHI; J GONG; Y OSADA
  PLASMA POLYMERIZATION AND PLASMA INTERACTIONS WITH POLYMERIC MATERIALS, 46, 289, 314, 1990, [Invited]
  English, International conference proceedings