SAKAI Ryuichiresearchmap個人ページ

Last Updated : 2017/09/19

Basic Information

Profile

Affiliation
Faculty of Fisheries Sciences Marine Life Science Marine Bioresources Chemistry
Job TitleProfessor 
Degree
Ph.D.
E-mail
URL
Research funding number

Research Keywords

Dysidea herbacea, Marine Natural Products chemistry

Research Areas

Neuroscience / Neurochemistry/Neuropharmacology
Fisheries science / Fisheries chemistry
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Neuroscience / Neurochemistry/Neuropharmacology
Fisheries science / Fisheries chemistry

Academic Background

-
1992
University of Illinois at Urban
-
1983
University of the Ryukyus
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-
1992
University of Illinois at Urban
-
1983
University of the Ryukyus

Research Activities

Papers

A monocyclic neodysiherbaine analog: Synthesis and evaluation.
Fukushima K, Ishikawa Y, Sakai R, Oikawa M
Bioorganic & medicinal chemistry letters 26(21) 5164-5167 2016/11
Three-Component, Diastereoselective Prins-Ritter Reaction for cis-Fused 4-Amidotetrahydropyrans toward a Precursor for Possible Neuronal Receptor Ligands.
Chiba M, Ishikawa Y, Sakai R, Oikawa M
ACS combinatorial science 18(7) 399-404 2016/07
Crystal structure of a symbiosis-related lectin from octocoral.
Kita A, Jimbo M, Sakai R, Morimoto Y, Miki K
Glycobiology 25(9) 1016-1023 2015/09
Structure-activity relationships of IKM-159: Diverted synthesis and biological evaluation of a series of C5-oxy analogs.
Chiba M, Fujimoto C, Sakai R, Oikawa M
Bioorganic & medicinal chemistry letters 25(9) 1869-1871 2015/05
Production of avaroferrin and putrebactin by heterologous expression of a deep-sea metagenomic DNA.
Fujita MJ, Sakai R
Marine drugs 12(9) 4799-4809 2014/09
Protoaculeine B, a putative N-terminal residue for the novel peptide toxin aculeines.
Matsunaga S, Kishi R, Otsuka K, Fujita MJ, Oikawa M, Sakai R
Organic letters 16(11) 3090-3093 2014/06
Modulation of ionotropic glutamate receptor function by vertebrate galectins.
Copits BA, Vernon CG, Sakai R, Swanson GT
The Journal of physiology 592(10) 2079-2096 2014/04
Practical synthesis of kainoids: a new chemical probe precursor and a fluorescent probe.
Sasaki S, Suzuki H, Ouchi H, Asakawa T, Inai M, Sakai R, Shimamoto K, Hamashima Y, Kan T
Organic letters 16(2) 564-567 2014/01
Recent progress in neuroactive marine natural products.
Sakai R, Swanson GT
Natural product reports 31(2) 273-309 2014/01
Heterologous production of desferrioxamines with a fusion biosynthetic gene cluster.
Fujita MJ, Sakai R
Bioscience, biotechnology, and biochemistry 77(12) 2467-2472 2013/12
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A monocyclic neodysiherbaine analog: Synthesis and evaluation.
Fukushima K, Ishikawa Y, Sakai R, Oikawa M
Bioorganic & medicinal chemistry letters 26(21) 5164-5167 2016/11
Three-Component, Diastereoselective Prins-Ritter Reaction for cis-Fused 4-Amidotetrahydropyrans toward a Precursor for Possible Neuronal Receptor Ligands.
Chiba M, Ishikawa Y, Sakai R, Oikawa M
ACS combinatorial science 18(7) 399-404 2016/07
Crystal structure of a symbiosis-related lectin from octocoral.
Kita A, Jimbo M, Sakai R, Morimoto Y, Miki K
Glycobiology 25(9) 1016-1023 2015/09
Structure-activity relationships of IKM-159: Diverted synthesis and biological evaluation of a series of C5-oxy analogs.
Chiba M, Fujimoto C, Sakai R, Oikawa M
Bioorganic & medicinal chemistry letters 25(9) 1869-1871 2015/05
Production of avaroferrin and putrebactin by heterologous expression of a deep-sea metagenomic DNA.
Fujita MJ, Sakai R
Marine drugs 12(9) 4799-4809 2014/09
Protoaculeine B, a putative N-terminal residue for the novel peptide toxin aculeines.
Matsunaga S, Kishi R, Otsuka K, Fujita MJ, Oikawa M, Sakai R
Organic letters 16(11) 3090-3093 2014/06
Modulation of ionotropic glutamate receptor function by vertebrate galectins.
Copits BA, Vernon CG, Sakai R, Swanson GT
The Journal of physiology 592(10) 2079-2096 2014/04
Practical synthesis of kainoids: a new chemical probe precursor and a fluorescent probe.
Sasaki S, Suzuki H, Ouchi H, Asakawa T, Inai M, Sakai R, Shimamoto K, Hamashima Y, Kan T
Organic letters 16(2) 564-567 2014/01
Recent progress in neuroactive marine natural products.
Sakai R, Swanson GT
Natural product reports 31(2) 273-309 2014/01
Heterologous production of desferrioxamines with a fusion biosynthetic gene cluster.
Fujita MJ, Sakai R
Bioscience, biotechnology, and biochemistry 77(12) 2467-2472 2013/12
Bisucaberin B, a linear hydroxamate class siderophore from the marine bacterium Tenacibaculum mesophilum.
Fujita MJ, Nakano K, Sakai R
Molecules (Basel, Switzerland) 18(4) 3917-3926 2013/04
Studies on an (S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) receptor antagonist IKM-159: asymmetric synthesis, neuroactivity, and structural characterization.
Juknaitė L, Sugamata Y, Tokiwa K, Ishikawa Y, Takamizawa S, Eng A, Sakai R, Pickering DS, Frydenvang K, Swanson GT, Kastrup JS, Oikawa M
Journal of medicinal chemistry 56 2283-2293 2013/03
Isolation of Novel Prototype Galectins from the Marine Ball Sponge Cinachyrella sp. Guided by Their Modulatory Activity on Mammalian Glutamate-gated Ion Channels.
Ueda T, Nakamura Y, Smith C, Copits BA, Inoue A, Ojima T, Matsunaga S, Swanson GT, Sakai R
Glycobiology 2012/12
Structure of a tetrameric galectin from Cinachyrella sp. (ball sponge).
Freymann DM, Nakamura Y, Focia PJ, Sakai R, Swanson GT
Acta crystallographica. Section D, Biological crystallography 68 1163-1174 2012/09
Binding and selectivity of the marine toxin neodysiherbaine A and its synthetic analogues to GluK1 and GluK2 kainate receptors.
Unno M, Shinohara M, Takayama K, Tanaka H, Teruya K, Doh-ura K, Sakai R, Sasaki M, Ikeda-Saito M
Journal of molecular biology 413(3) 667-683 2011/10
Isolation, amino acid sequence and biological activities of novel long-chain polyamine-associated peptide toxins from the sponge Axinyssa aculeata.
Matsunaga S, Jimbo M, Gill MB, Wyhe LL, Murata M, Nonomura K, Swanson GT, Sakai R
Chembiochem : a European journal of chemical biology 12(14) 2191-2200 2011/09
Antinociceptive effects of MSVIII-19, a functional antagonist of the GluK1 kainate receptor.
Qiu CS, Lash-Van Wyhe L, Sasaki M, Sakai R, Swanson GT, Gereau RW 4th
Pain 152(5) 1052-1060 2011/05
Novel N-methylated 8-oxoisoguanines from Pacific sponges with diverse neuroactivities.
Sakurada T, Gill MB, Frausto S, Copits B, Noguchi K, Shimamoto K, Swanson GT, Sakai R
Journal of medicinal chemistry 53(16) 6089-6099 2010/08
Improved synthesis and in vitro/in vivo activities of natural product-inspired, artificial glutamate analogs.
Oikawa M, Ikoma M, Sasaki M, Gill MB, Swanson GT, Shimamoto K, Sakai R
Bioorganic & medicinal chemistry 18(11) 3795-3804 2010/06
Pharmacological activity of C10-substituted analogs of the high-affinity kainate receptor agonist dysiherbaine.
Lash-Van Wyhe LL, Postila PA, Tsubone K, Sasaki M, Pentikäinen OT, Sakai R, Swanson GT
Neuropharmacology 58(3) 640-649 2010/03
Regioselective Domino Metathesis of Unsymmetrical 7-Oxanorbornenes with Electron-Rich Vinyl Acetate toward Biologically Active Glutamate Analogues.
Oikawa M, Ikoma M, Sasaki M, Gill MB, Swanson GT, Shimamoto K, Sakai R
European journal of organic chemistry 2009(32) 5531-5548 2009/11
Full domain closure of the ligand-binding core of the ionotropic glutamate receptor iGluR5 induced by the high affinity agonist dysiherbaine and the functional antagonist 8,9-dideoxyneodysiherbaine.
Frydenvang K, Lash LL, Naur P, Postila PA, Pickering DS, Smith CM, Gajhede M, Sasaki M, Sakai R, Pentikaïnen OT, Swanson GT, Kastrup JS
The Journal of biological chemistry 284(21) 14219-14229 2009/05
Ligands for ionotropic glutamate receptors.
Swanson GT, Sakai R
Progress in molecular and subcellular biology 46 123-157 2009
Regioselective Domino Metathesis of 7-Oxanorbornenes and Its Application to the Synthesis of Biologically Active Glutamate Analogues.
Ikoma M, Oikawa M, Gill MB, Swanson GT, Sakai R, Shimamoto K, Sasaki M
European journal of organic chemistry 2008(31) 5215-5220 2008/11
Cellular origin of dysiherbaine, an excitatory amino acid derived from a marine sponge.
Sakai R, Yoshida K, Kimura A, Koike K, Jimbo M, Koike K, Kobiyama A, Kamiya H
Chembiochem : a European journal of chemical biology 9 543-551 2008/03
Novel analogs and stereoisomers of the marine toxin neodysiherbaine with specificity for kainate receptors.
Lash LL, Sanders JM, Akiyama N, Shoji M, Postila P, Pentikäinen OT, Sasaki M, Sakai R, Swanson GT
The Journal of pharmacology and experimental therapeutics 324 484-496 2008/02
Rapid and efficient synthesis of dysiherbaine and analogues to explore structure-activity relationships.
Sasaki M, Tsubone K, Aoki K, Akiyama N, Shoji M, Oikawa M, Sakai R, Shimamoto K
The Journal of organic chemistry 73(1) 264-273 2008/01
Long-chain polyamines (LCPAs) from marine sponge: possible implication in spicule formation.
Matsunaga S, Sakai R, Jimbo M, Kamiya H
Chembiochem : a European journal of chemical biology 8 1729-1735 2007/09
Purification, cloning and characterization of egg lectins from the teleost Tribolodon brandti.
Jimbo M, Usui R, Sakai R, Muramoto K, Kamiya H
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 147(2) 164-171 2007/06
Myriaporones 1-4, cytotoxic metabolites from the Mediterranean bryozoan Myriapora truncata.
Cheng JF, Lee JS, Sakai R, Jares-Erijman EA, Silva MV, Rinehart KL
Journal of natural products 70(3) 332-336 2007/03
Design, total synthesis, and biological evaluation of neodysiherbaine A derivative as potential probes.
Sasaki M, Tsubone K, Shoji M, Oikawa M, Shimamoto K, Sakai R
Bioorganic & medicinal chemistry letters 16(22) 5784-5787 2006/11
1-Deoxynojirimycin derivatives from the marine sponge Lendenfeldia chondrodes.
Sakai R, Kamiya H
The Journal of antibiotics 59(8) 507-511 2006/08
Total synthesis and biological evaluation of neodysiherbaine A and analogues.
Shoji M, Akiyama N, Tsubone K, Lash LL, Sanders JM, Swanson GT, Sakai R, Shimamoto K, Oikawa M, Sasaki M
The Journal of organic chemistry 71(14) 5208-5220 2006/07
Determination of binding site residues responsible for the subunit selectivity of novel marine-derived compounds on kainate receptors.
Sanders JM, Pentikäinen OT, Settimo L, Pentikäinen U, Shoji M, Sasaki M, Sakai R, Johnson MS, Swanson GT
Molecular pharmacology 69 1849-1860 2006/06
Cellular and subcellular localization of kainic acid in the marine red alga Digenea simplex.
Sakai R, Minato S, Koike K, Koike K, Jimbo M, Kamiya H
Cell and tissue research 322 491-502 2005/12
Xanthocillins as thrombopoietin mimetic small molecules.
Sakai R, Nakamura T, Nishino T, Yamamoto M, Miyamura A, Miyamoto H, Ishiwata N, Komatsu N, Kamiya H, Tsuruzoe N
Bioorganic & medicinal chemistry 13 6388-6393 2005/12
Divergent pharmacological activity of novel marine-derived excitatory amino acids on glutamate receptors.
Sanders JM, Ito K, Settimo L, Pentikäinen OT, Shoji M, Sasaki M, Johnson MS, Sakai R, Swanson GT
The Journal of pharmacology and experimental therapeutics 314 1068-1078 2005/09
Cloning and characterization of a lectin from the octocoral Sinularia lochmodes.
Jimbo M, Koike K, Sakai R, Muramoto K, Kamiya H
Biochemical and biophysical research communications 330(1) 157-162 2005/04
Octocoral chemical signaling selects and controls dinoflagellate symbionts.
Koike K, Jimbo M, Sakai R, Kaeriyama M, Muramoto K, Ogata T, Maruyama T, Kamiya H
The Biological bulletin 207 80-86 2004/10
Characterization of novel L-threo-beta-benzyloxyaspartate derivatives, potent blockers of the glutamate transporters.
Shimamoto K, Sakai R, Takaoka K, Yumoto N, Nakajima T, Amara SG, Shigeri Y
Molecular pharmacology 65 1008-1015 2004/04
Novel betaines from a micronesian sponge Dysidea herbacea.
Sakai R, Suzuki K, Shimamoto K, Kamiya H
The Journal of organic chemistry 69(4) 1180-1185 2004/02
Isolations of N-methyl-D-aspartic acid-type glutamate receptor ligands from Micronesian sponges.
Sakai R, Matsubara H, Shimamoto K, Jimbo M, Kamiya H, Namikoshi M
Journal of natural products 66(6) 784-787 2003/06
Isolation, structure determination, and synthesis of neodysiherbaine A, a new excitatory amino acid from a marine sponge.
Sakai R, Koike T, Sasaki M, Shimamoto K, Oiwa C, Yano A, Suzuki K, Tachibana K, Kamiya H
Organic letters 3(10) 1479-1482 2001/05
Pharmacological properties of the potent epileptogenic amino acid dysiherbaine, a novel glutamate receptor agonist isolated from the marine sponge Dysidea herbacea.
Sakai R, Swanson GT, Shimamoto K, Green T, Contractor A, Ghetti A, Tamura-Horikawa Y, Oiwa C, Kamiya H
The Journal of pharmacology and experimental therapeutics 296 650-658 2001/02
Identification of thioether intermediates in the reductive transformation of gonyautoxins into saxitoxins by thiols.
Sato S, Sakai R, Kodama M
Bioorganic & medicinal chemistry letters 10(16) 1787-1789 2000/08
The D-galactose-binding lectin of the octocoral Sinularia lochmodes: characterization and possible relationship to the symbiotic dinoflagellates.
Jimbo M, Yanohara T, Koike K, Koike K, Sakai R, Muramoto K, Kamiya H
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 125 227-236 2000/02
Purification and characterization of Microcystis aeruginosa (freshwater cyanobacterium) lectin.
Yamaguchi M, Jimbo M, Sakai R, Muramoto K, Kamiya H
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 119 593-597 1998/03
Structure--activity relationships of the didemnins.
Sakai R, Rinehart KL, Kishore V, Kundu B, Faircloth G, Gloer JB, Carney JR, Namikoshi M, Sun F, Hughes RG Jr, García Grávalos D, de Quesada TG, Wilson GR, Heid RM
Journal of medicinal chemistry 39(14) 2819-2834 1996/07
A new polyether acid from a cold water marine sponge, a Phakellia species.
Sakai R, Rinehart KL
Journal of natural products 58(5) 773-777 1995/05
Molecular and crystal structures of ecteinascidins: potent antitumor compounds from the Caribbean tunicate Ecteinascidia turbinata.
Guan Y, Sakai R, Rinehart KL, Wang AH
Journal of biomolecular structure & dynamics 10 793-818 1993/04
Bioactive compounds from aquatic and terrestrial sources.
Rinehart KL, Holt TG, Fregeau NL, Keifer PA, Wilson GR, Perun TJ Jr, Sakai R, Thompson AG, Stroh JG, Shield LS
Journal of natural products 53(4) 771-792 1990/07
Erratum - " Didemnins and Tunichlorin: Novel Natural Products from the Marine Tunicate Trididemnum solidum.
Rinehart KL, Kishore V, Bible KC, Sakai R, Sullins DW, Li KM
Journal of natural products 51 624 1988/05
Didemnins and tunichlorin: novel natural products from the marine tunicate Trididemnum solidum.
Rinehart KL, Kishore V, Bible KC, Sakai R, Sullins DW, Li KM
Journal of natural products 51 1-21 1988/01

Research Projects (Competitive Research Funds)

Analysis and generation of functional molecules to modulate neutral amino acid transporters
Ministry of Education, Culture, Sports, Science and Technology : Grants-in-Aid for Scientific Research(基盤研究(C))
Date (from‐to) : 2007-2009 Author : Yasushi SHIGERI
Sponge-derived neurotoxic substances : Structure, Bioactivity, and their cellular localization.
Ministry of Education, Culture, Sports, Science and Technology : Grants-in-Aid for Scientific Research(基盤研究(B))
Date (from‐to) : 2005-2007 Author : Ryuichi SAKAI
Selection and Morphological Alteration of dinoflagellates symbionts by chemical substances in marine invertebrates
Ministry of Education, Culture, Sports, Science and Technology : Grants-in-Aid for Scientific Research(基盤研究(B))
Date (from‐to) : 2003-2005 Author : Hisao KAMIYA
Biochemical investigations on the cells that localizes dysiherbaine in marine sponge Dysidea herbacea.
Ministry of Education, Culture, Sports, Science and Technology : Grants-in-Aid for Scientific Research(基盤研究(C))
Date (from‐to) : 2003-2004 Author : Ryuichi SAKAI
Development of simple analyzing method for paralytic shellfish toxins by ELISA
Ministry of Education, Culture, Sports, Science and Technology : Grants-in-Aid for Scientific Research(基盤研究(B))
Date (from‐to) : 2000-2003 Author : Shigeru SATO
Structure and Function of the Octocoral Sinularia lochmodes lectin
Ministry of Education, Culture, Sports, Science and Technology : Grants-in-Aid for Scientific Research(基盤研究(B))
Date (from‐to) : 2000-2002 Author : Hisao KAMIYA
Isolation and structure determination of Bioactive Marine natural products.
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Research Projects (Competitive Research Funds)close
Analysis and generation of functional molecules to modulate neutral amino acid transporters
Ministry of Education, Culture, Sports, Science and Technology : Grants-in-Aid for Scientific Research(基盤研究(C))
Date (from‐to) : 2007-2009 Author : Yasushi SHIGERI
Sponge-derived neurotoxic substances : Structure, Bioactivity, and their cellular localization.
Ministry of Education, Culture, Sports, Science and Technology : Grants-in-Aid for Scientific Research(基盤研究(B))
Date (from‐to) : 2005-2007 Author : Ryuichi SAKAI
Selection and Morphological Alteration of dinoflagellates symbionts by chemical substances in marine invertebrates
Ministry of Education, Culture, Sports, Science and Technology : Grants-in-Aid for Scientific Research(基盤研究(B))
Date (from‐to) : 2003-2005 Author : Hisao KAMIYA
Biochemical investigations on the cells that localizes dysiherbaine in marine sponge Dysidea herbacea.
Ministry of Education, Culture, Sports, Science and Technology : Grants-in-Aid for Scientific Research(基盤研究(C))
Date (from‐to) : 2003-2004 Author : Ryuichi SAKAI
Development of simple analyzing method for paralytic shellfish toxins by ELISA
Ministry of Education, Culture, Sports, Science and Technology : Grants-in-Aid for Scientific Research(基盤研究(B))
Date (from‐to) : 2000-2003 Author : Shigeru SATO
Structure and Function of the Octocoral Sinularia lochmodes lectin
Ministry of Education, Culture, Sports, Science and Technology : Grants-in-Aid for Scientific Research(基盤研究(B))
Date (from‐to) : 2000-2002 Author : Hisao KAMIYA
Isolation and structure determination of Bioactive Marine natural products.

Educational Activities

Classes

Introduction to Fisheries Sciences Ⅱ
Year : 2015
Natural Product Chemistry
Year : 2015
Introduction to Fisheries Sciences Ⅱ
Year : 2015
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Introduction to Fisheries Sciences Ⅱ
Year : 2015
Natural Product Chemistry
Year : 2015
Introduction to Fisheries Sciences Ⅱ
Year : 2015
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Introduction to Fisheries Sciences Ⅱ
Year : 2014
Natural Product Chemistry
Year : 2014
Teaching Method of School Subjects(Fishery Ⅱ)
Year : 2014
Introduction to Fisheries Sciences Ⅱ
Year : 2014
Environment and People
Year : 2014
Environment and People
Year : 2014
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Introduction to Fisheries Sciences Ⅱ
Year : 2013
Natural Product Chemistry
Year : 2013
Introduction to Fisheries Sciences Ⅱ
Year : 2013
Study and Training of Marine Research Diving
Year : 2013
Environment and People
Year : 2013
Environment and People
Year : 2013

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