Researcher Database

Masanobu Suzuki
Faculty of Medicine Specialized Medicine Sensory Organ Medicine
Assistant Professor

Researcher Profile and Settings


  • Faculty of Medicine Specialized Medicine Sensory Organ Medicine

Job Title

  • Assistant Professor

J-Global ID

Research Areas

  • Life sciences / Otorhinolaryngology

Association Memberships

  • American rhinologic society   日本耳鼻咽喉科臨床学会   日本耳鼻咽喉科免疫アレルギー学会   日本鼻科学会   日本アレルギー学会   日本耳鼻咽喉科学会   

Research Activities

Published Papers

  • Shinya Morita, Yuji Nakamaru, Daigo Nakazawa, Masanobu Suzuki, Kimiko Hoshino, Atsushi Fukuda, Fumihiko Hattanda, Kanako Kusunoki, Utano Tomaru, Akihiro Ishizu, Akihiro Homma
    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 40 (2) e99-e106 - e106 1531-7129 2019/02 [Refereed][Not invited]
    OBJECTIVE: This prospective study aimed to evaluate the diagnostic and clinical utility of the myeloperoxidase (MPO)-DNA complex as a NETosis-derived product in the middle ear fluid of patients with otitis media with antineutrophil cytoplasmic antibody-associated vasculitis (OMAAV). STUDY DESIGN: Prospective study. SETTING: Tertiary referral center. PATIENTS: Twenty-two patients diagnosed with OMAAV. INTERVENTION: Collection of the fluid samples from middle ear. MAIN OUTCOME MEASURE: The levels of the MPO-DNA complex in the fluid samples were quantified using an enzyme-linked immunosorbent assay. RESULTS: Patients with both systemic and localized forms of OMAAV showed significantly higher levels of the MPO-DNA complex compared to the controls (p < 0.001 and p = 0.002, respectively). In particular, they showed significantly higher levels of MPO-DNA complex compared to the controls, regardless of serum antineutrophil cytoplasmic antibody status (p < 0.001 and p < 0.001, respectively) or immunosuppressive therapy (p < 0.001 and p < 0.001, respectively) at the time of sampling. An optical density cutoff value of 0.16 at 405 nm according to the receiver operating characteristic curve showed a sensitivity of 86.4%, specificity of 95.5%, positive predictive value of 95.0% and negative predictive value of 87.5% for the diagnosis of OMAAV. Significant positive correlations were observed between the levels of MPO-DNA complex and the values for air conduction - (r = 0.49, p = 0.022) and bone conduction - pure tone average thresholds (r = 0.45, p = 0.035). CONCLUSIONS: The detection and quantification of the MPO-DNA complex in the otitis media fluid may aid in providing a definite diagnosis as well as predicting the activity and severity of OMAAV.
  • 鼻粘膜上皮細胞においてSIRT-1はPolyICに誘導されるMMP9を負に制御する
    鈴木 正宣, 中丸 裕爾, 高木 大, 本間 あや, Vreugde Sarah, Wormald Peter-John, 本間 明宏
    耳鼻咽喉科免疫アレルギー 日本耳鼻咽喉科免疫アレルギー学会 36 (2) 118 - 119 0913-0691 2018/06 [Not refereed][Not invited]
  • Shinichiro Yasukawa, Satoshi Kano, Hiromitsu Hatakeyama, Yuji Nakamaru, Dai Takagi, Takatsugu Mizumachi, Masanobu Suzuki, Takayoshi Suzuki, Akira Nakazono, Shinya Tanaka, Hiroshi Nishihara, Akihiro Homma
    International Journal of Clinical Oncology 1 - 9 1437-7772 2018/05/19 [Refereed][Not invited]
    Background: The mechanism underlying the malignant transformation of inverted papilloma (IP) has not yet been elucidated. Methods: To clarify the genes responsible for the malignant transformation, we analyzed 10 cases of IP, 8 of IP with dysplasia, and 11 of squamous cell carcinoma (SCC) by targeted amplicon sequencing. Results: The number of mutant genes increased in the order of IP < dysplasia < SCC. Significant differences were observed in the mutation rates of three genes (KRAS, APC and STK11) in particular. TP53 was altered frequently in each group and might be involved in malignant transformation based on to the site of the mutation. A comparison of the genetic variants by region of IP tissue among patients with IP alone, and those with dysplasia or SCC revealed significant differences in the mutation rate of the KRAS gene. Conclusion: Identification of genetic mutations in KRAS is effective for predicting the malignant transformation of IP.
  • 唾液腺導管癌における免疫染色およびRT-PCR法を用いた分子生物学的プロファイルの検討
    鈴木 崇祥, 加納 里志, 畑中 佳奈子, 鈴木 正宣, 安川 真一郎, 中薗 彬, 水町 貴諭, 畑中 豊, 松野 吉宏, 本間 明宏
    頭頸部癌 (一社)日本頭頸部癌学会 44 (2) 179 - 179 1349-5747 2018/05 [Not refereed][Not invited]
  • Suzuki M, Ramezanpour M, Cooksley C, Li J, Nakamaru Y, Homma A, Psaltis A, Wormald PJ, Vreugde S
    American journal of respiratory cell and molecular biology 1044-1549 2018/05 [Refereed][Not invited]
  • 中丸 裕爾, 高木 大, 鈴木 正宣, 加納 里志, 水町 貴諭, 中薗 彬, 本間 明宏
    日本耳鼻咽喉科学会会報 (一社)日本耳鼻咽喉科学会 121 (4) 567 - 567 0030-6622 2018/04 [Not refereed][Not invited]
  • 鈴木 崇祥, 加納 里志, 鈴木 正宣, 安川 真一郎, 中薗 彬, 水町 貴諭, 本間 明宏
    日本耳鼻咽喉科学会会報 (一社)日本耳鼻咽喉科学会 121 (4) 541 - 541 0030-6622 2018/04 [Not refereed][Not invited]
  • 鼻副鼻腔内反性乳頭腫の悪性転化に関与する遺伝子変異の解析
    安川 真一郎, 加納 里志, 畠山 博充, 中丸 裕爾, 高木 大, 水町 貴諭, 鈴木 正宣, 鈴木 崇祥, 中薗 彬, 本間 明宏
    日本耳鼻咽喉科学会会報 (一社)日本耳鼻咽喉科学会 121 (4) 539 - 539 0030-6622 2018/04 [Not refereed][Not invited]
  • Shinya Morita, Yuji Nakamaru, Daigo Nakazawa, Fumihiko Hattanda, Haruki Shida, Yoshihiro Kusunoki, Kanako Watanabe, Sakiko Masuda, Dai Takagi, Masanobu Suzuki, Kimiko Hoshino, Atsushi Fukuda, Utano Tomaru, Akihiro Homma, Akihiro Ishizu
    Otology and Neurotology 39 (4) e257 - e262 1537-4505 2018/04/01 [Refereed][Not invited]
    Objective:The purpose was to explore the presence of myeloperoxidase (MPO)-deoxyribonucleic acid (DNA) complex as a surrogate marker of neutrophil extracellular traps (NETs) in the middle ear fluid, and to clarify the correlation between its quantifiable level and hearing outcome in patients with otitis media associated with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).Study Design:Prospective study.Setting:Tertiary referral center.Patients:Nine AAV patients presenting with otitis media.Intervention:Collection of the fluid samples from middle ear.Main Outcome Measure:The quantifiable levels of MPO-DNA complex using an enzyme-linked immunosorbent assay.Results:The quantifiable levels of MPO-DNA complex in patients with AAV were significantly higher than those in controls (p < 0.001). In particular, both ANCA-positive and-negative cases indicated higher levels of MPO-DNA complex compared with the controls (p = 0.004 and p = 0.006, respectively). The significant negative correlations were observed between the level of MPO-DNA complex and the functional hearing values for air (r =-0.82, p = 0.009) and bone conduction (r =-0.73, p = 0.028), respectively.Conclusion:This analysis is the first to reveal the presence of elevated levels of MPO-DNA complex in the middle ear fluid, suggesting the pathogenic role of NETs in otitis media associated with AAV. NETs may be a valuable biomarker for use in clinical decision-making and predicting hearing outcome, regardless of ANCA status.
  • 鼻粘膜上皮細胞での自然免疫シグナルによるMMP9の発現誘導
    鈴木 正宣, 中丸 裕爾, 高木 大, 本間 あや, Vreugde Sarah, Wormald Peter-John, 本間 明宏
    日本鼻科学会会誌 (一社)日本鼻科学会 56 (3) 429 - 429 0910-9153 2017/09 [Not refereed][Not invited]
  • 鼻粘膜上皮細胞での自然免疫シグナルによるMMP9の発現誘導
    鈴木 正宣, 中丸 裕爾, 高木 大, 本間 あや, Vreugde Sarah, Wormald Peter-John, 本間 明宏
    日本鼻科学会会誌 (一社)日本鼻科学会 56 (3) 429 - 429 0910-9153 2017/09 [Not refereed][Not invited]
  • IgG4関連疾患における鼻副鼻腔病変の検討
    高木 大, 中丸 裕爾, 鈴木 正宣, 本間 あや, 福田 諭
    耳鼻咽喉科免疫アレルギー 日本耳鼻咽喉科免疫アレルギー学会 35 (2) 238 - 239 0913-0691 2017/08 [Not refereed][Not invited]
  • 高木 大, 中丸 裕爾, 鈴木 正宣, 本間 あや, 福田 諭
    日本耳鼻咽喉科学会会報 (一社)日本耳鼻咽喉科学会 120 (4) 557 - 557 0030-6622 2017/04 [Not refereed][Not invited]
  • A. Honma, D. Takagi, Y. Nakamaru, A. Homma, M. Suzuki, S. Fukuda
    JOURNAL OF LARYNGOLOGY AND OTOLOGY 130 (12) 1147 - 1152 0022-2151 2016/12 [Refereed][Not invited]
    Objective: This study aimed to predict eosinophilic chronic rhinosinusitis prognosis by investigating changes in the blood eosinophil count and other disease biomarkers after surgery. Methods: Blood eosinophil numbers and serum interleukin- 5 levels were measured in 22 eosinophilic chronic rhinosinusitis patients before and after functional endoscopic sinus surgery, and compared with equivalent measures in non-eosinophilic chronic rhinosinusitis patients and chronic rhinosinusitis without polyps patients. Differences between well-controlled eosinophilic chronic rhinosinusitis patients and those who experienced recurrence were also assessed. Results: Blood eosinophil numbers and serum interleukin- 5 level decreased after surgery in eosinophilic chronic rhinosinusitis patients. In this patient group, blood eosinophil counts before surgery were significantly higher in patients who experienced recurrence (825.7 +/- 26.1 vs 443.9 +/- 76.6 cells/mu l, p < 0.05), and decreased significantly after surgery (825.7 +/- 26.1 vs 76.7 +/- 25.8 cells/mu l, p < 0.05). Conclusion: Blood eosinophil numbers may reflect disease severity in eosinophilic chronic rhinosinusitis patients and their prognosis after surgery.
  • アレルギー性鼻炎モデルマウスにおける鼻粘膜時計遺伝子発現リズム
    本間 あや, 中丸 裕爾, 高木 大, 鈴木 正宣, 福田 諭
    日本鼻科学会会誌 (一社)日本鼻科学会 55 (3) 468 - 468 0910-9153 2016/09 [Not refereed][Not invited]
  • Masanobu Suzuki, Keishi Fujiwara, Takashi Tsubuku, Ichiro Yabe, Hidenao Sasaki, Satoshi Fukuda
    JOURNAL OF THE NEUROLOGICAL SCIENCES 368 206 - 208 0022-510X 2016/09 [Refereed][Not invited]
  • Delnur Anwar, Hidehisa Takahashi, Masashi Watanabe, Masanobu Suzuki, Satoshi Fukuda, Shigetsugu Hatakeyama
    BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS 1859 (8) 975 - 982 1874-9399 2016/08 [Refereed][Not invited]
    The regulation of transcription by RNA polymerase II (Pol II) is important for a variety of cellular functions. ELL/EAF-containing little elongation complex (LEC) was found to be required for transcription of Pol II-dependent small nuclear RNA (snRNA) genes. It was shown that the tumor suppressor p53 interacts with ELL and inhibits transcription elongation activity of ELL Here, we show that p53 inhibits interaction between ELL/EAF and ICE1 in LEC and thereby p53 represses transcription of Pol II-dependent snRNA genes through inhibiting LEC function. Furthermore, induction of p53 expression by ultraviolet (UV) irradiation decreases the occupancy of ICE1 at Pol II-dependent snRNA genes. Consistent with the results, knockdown of p53 increased both the expression of snRNA genes and the occupancy of Pol II and components of LEC at snRNA genes. Our results indicate that p53 interferes with the interaction between ELL/EAF and ICE1 and represses transcription of snRNA genes by Pol II. (C) 2016 Elsevier B.V. All rights reserved.
  • Anwar D, Takahashi H, Watanabe M, Suzuki M, Fukuda S, Hatakeyama S
    Biochimica et biophysica acta 1859 (8) 975 - 982 0006-3002 2016/08 [Refereed][Not invited]
  • IgG4関連疾患における鼻副鼻腔病変の検討
    高木 大, 中丸 裕爾, 鈴木 正宣, 本間 あや, 福田 諭
    耳鼻咽喉科免疫アレルギー 日本耳鼻咽喉科免疫アレルギー学会 34 (2) 179 - 180 0913-0691 2016/06 [Not refereed][Not invited]
  • 好酸球性多発血管炎性肉芽腫症(EGPA)の耳症状
    中丸 裕爾, 高木 大, 鈴木 正宣, 本間 あや, 福田 諭
    耳鼻咽喉科免疫アレルギー 日本耳鼻咽喉科免疫アレルギー学会 34 (2) 139 - 139 0913-0691 2016/06 [Not refereed][Not invited]
  • グルココルチコイドによる鼻粘膜末梢時計の調整 PER2発光リズムを指標とした解析
    本間 あや, 中丸 裕爾, 高木 大, 鈴木 正宣, 本間 研一, 本間 さと, 福田 諭
    耳鼻咽喉科免疫アレルギー 日本耳鼻咽喉科免疫アレルギー学会 34 (2) 56 - 57 0913-0691 2016/06 [Not refereed][Not invited]
  • 膠原病・自己免疫疾患 膠原病と自己炎症性疾患 IgG4関連疾患における鼻副鼻腔病変の検討
    高木 大, 中丸 裕爾, 鈴木 正宣, 本間 あや, 福田 諭
    アレルギー (一社)日本アレルギー学会 65 (4-5) 557 - 557 0021-4884 2016/05 [Not refereed][Not invited]
  • 本間 あや, 中丸 裕爾, 高木 大, 鈴木 正宣, 福田 諭, 本間 研一, 本間 さと
    日本耳鼻咽喉科学会会報 (一社)日本耳鼻咽喉科学会 119 (4) 636 - 636 0030-6622 2016/04 [Not refereed][Not invited]
  • Masanobu Suzuki, Masashi Watanabe, Yuji Nakamaru, Dai Takagi, Hidehisa Takahashi, Satoshi Fukuda, Shigetsugu Hatakeyama
    CELLULAR AND MOLECULAR LIFE SCIENCES 73 (5) 1085 - 1101 1420-682X 2016/03 [Refereed][Not invited]
    NF kappa B is one of the central regulators of cell survival, immunity, inflammation, carcinogenesis and organogenesis. The activation of NF kappa B is strictly regulated by several posttranslational modifications including phosphorylation, neddylation and ubiquitination. Several types of ubiquitination play important roles in multi-step regulations of the NF kappa B pathway. Some of the tripartite motif-containing (TRIM) proteins functioning as E3 ubiquitin ligases are known to regulate various biological processes such as inflammatory signaling pathways. One of the TRIM family proteins, TRIM39, for which the gene has single nucleotide polymorphisms, has been identified as one of the genetic factors in Behcet's disease. However, the role of TRIM39 in inflammatory signaling had not been fully elucidated. In this study, to elucidate the function of TRIM39 in inflammatory signaling, we performed yeast two-hybrid screening using TRIM39 as a bait and identified Cactin, which has been reported to inhibit NF kappa B- and TLR-mediated transcriptions. We show that TRIM39 stabilizes Cactin protein and that Cactin is upregulated after TNF alpha stimulation. TRIM39 knockdown also causes activation of the NF kappa B signal. These findings suggest that TRIM39 negatively regulates the NF kappa B signal in collaboration with Cactin induced by inflammatory stimulants such as TNF alpha.
  • Yuji Nakamaru, Dai Takagi, Masanobu Suzuki, Aya Homma, Shinya Morita, Akihiro Homma, Satoshi Fukuda
    AUDIOLOGY AND NEURO-OTOLOGY 21 (1) 45 - 53 1420-3030 2016 [Refereed][Not invited]
    Background: Eosinophilic granulomatosis with polyangiitis (EGPA) is a systemic autoimmune disease that manifests as asthma, recurrent sinusitis and peripheral eosinophilia. In this study, we investigated the clinical features of the ear and nasal manifestations of EGPA in comparison with those of granulomatosis with polyangiitis (GPA). Materials and Methods: Twenty-one patients diagnosed with EGPA were studied. The frequency of otologic manifestations, the degree of hearing loss and the frequency of nasal symptoms were assessed. The onset of ear symptoms, sinusitis and asthma in patients with EGPA were also examined. Results: Eleven patients (52.4%) with EGPA demonstrated otologic symptoms. The EGPA patients commonly presented mild-to-moderate mixed or sensorineural hearing loss. The pattern of hearing loss was mainly flat, and all but 1 patient achieved complete remission from their hearing impairments. Eighteen patients (85.7%) with EGPA demonstrated nasal symptoms. Patients with EGPA showed a significantly higher incidence of nasal polyps than did those with GPA. The median Lund and Mackey scoring system score was 13.7 for patients with EGPA, and ethmoid sinus shadows were more severe than those of the maxillary sinus. Most ear symptoms associated with EGPA were observed after definitive diagnosis, although sinusitis and asthma tended to manifest themselves before diagnosis. There were significant differences between the onset of ear symptoms and those of asthma and sinusitis. Conclusion: As over 80% of patients with EGPA had nasal symptoms and over half had ear symptoms, otolaryngologists should be aware of this disease. Recognition of the characteristic ear and nasal symptoms are thought to be particularly important to obtain an early diagnosis of EGPA. (C) 2016 S. Karger AG, Basel
  • 副鼻腔炎を合併したIgG4関連疾患症例
    高木 大, 中丸 裕爾, 鈴木 正宣, 本間 あや, 福田 諭
    アレルギーの臨床 (株)北隆館 35 (11) 1090 - 1092 0285-6379 2015/10 [Not refereed][Not invited]
  • 鼻粘膜時計遺伝子発現の概日リズムにグルココルチコイドが影響を及ぼす
    本間 あや, 中丸 裕爾, 高木 大, 鈴木 正宣, 本間 研一, 本間 さと, 福田 諭
    日本鼻科学会会誌 (一社)日本鼻科学会 54 (3) 376 - 376 0910-9153 2015/09 [Not refereed][Not invited]
  • 鈴木 正宣, 渡部 昌, 中丸 裕爾, 高木 大, 加納 里志, 本間 あや, 畠山 鎮次, 福田 諭
    耳鼻咽喉科免疫アレルギー 日本耳鼻咽喉科免疫アレルギー学会 33 (3) 185 - 192 0913-0691 2015/09 [Not refereed][Not invited]
  • 北海道上士幌町におけるアレルギー性疾患の疫学調査
    本間 あや, 中丸 裕爾, 高木 大, 鈴木 正宣, 今野 哲, 福田 諭
    耳鼻咽喉科免疫アレルギー 日本耳鼻咽喉科免疫アレルギー学会 33 (2) 128 - 129 0913-0691 2015/06 [Not refereed][Not invited]
  • 好酸球性副鼻腔炎における術後好酸球数の変動について
    高木 大, 本間 あや, 中丸 裕爾, 鈴木 正宣, 福田 諭
    耳鼻咽喉科免疫アレルギー 日本耳鼻咽喉科免疫アレルギー学会 33 (2) 50 - 51 0913-0691 2015/06 [Not refereed][Not invited]
  • Bechet病疾患感受性遺伝子Tripartite motif protein 39(TRIM39)の機能解析
    鈴木 正宣, 渡部 昌, 中丸 裕爾, 高木 大, 本間 あや, 畠山 鎮次, 福田 諭
    耳鼻咽喉科免疫アレルギー 日本耳鼻咽喉科免疫アレルギー学会 33 (2) 38 - 39 0913-0691 2015/06 [Not refereed][Not invited]
  • 好酸球性副鼻腔炎における術後好酸球数の変動
    高木 大, 中丸 裕爾, 本間 あや, 鈴木 正宣, 福田 諭
    アレルギー (一社)日本アレルギー学会 64 (3-4) 561 - 561 0021-4884 2015/04 [Not refereed][Not invited]
  • 本間 あや, 中丸 裕爾, 高木 大, 鈴木 正宣, 今野 哲, 福田 諭
    日本耳鼻咽喉科学会会報 (一社)日本耳鼻咽喉科学会 118 (4) 540 - 540 0030-6622 2015/04 [Not refereed][Not invited]
  • Masashi Watanabe, Hidehisa Takahashi, Yasushi Saeki, Takashi Ozaki, Shihori Itoh, Masanobu Suzuki, Wataru Mizushima, Keiji Tanaka, Shigetsugu Hatakeyama
    ELIFE 4 e05615  2050-084X 2015/04 [Refereed][Not invited]
    Adipocyte differentiation is a strictly controlled process regulated by a series of transcriptional activators. Adipogenic signals activate early adipogenic activators and facilitate the transient formation of early enhanceosomes at target genes. These enhancer regions are subsequently inherited by late enhanceosomes. PPAR gamma is one of the late adipogenic activators and is known as a master regulator of adipogenesis. However, the factors that regulate PPAR gamma expression remain to be elucidated. Here, we show that a novel ubiquitin E3 ligase, tripartite motif protein 23 (TRIM23), stabilizes PPAR gamma protein and mediates atypical polyubiquitin conjugation. TRIM23 knockdown caused a marked decrease in PPAR gamma protein abundance during preadipocyte differentiation, resulting in a severe defect in late adipogenic differentiation, whereas it did not affect the formation of early enhanceosomes. Our results suggest that TRIM23 plays a critical role in the switching from early to late adipogenic enhanceosomes by stabilizing PPAR gamma protein possibly via atypical polyubiquitin conjugation.
  • 好酸球性副鼻腔炎における術後好酸球数の変動について
    高木 大, 本間 あや, 中丸 裕爾, 鈴木 正宣, 福田 諭
    日本鼻科学会会誌 (一社)日本鼻科学会 53 (3) 418 - 418 0910-9153 2014/09 [Not refereed][Not invited]
  • 本間 あや, 中丸 裕爾, 高木 大, 鈴木 正宣, 今野 哲, 福田 諭
    日本鼻科学会会誌 (一社)日本鼻科学会 53 (3) 408 - 408 0910-9153 2014/09 [Not refereed][Not invited]
  • 鈴木 正宣, 渡部 昌, 高木 大, 中丸 裕爾, 畠山 鎮次, 福田 諭
    日本耳鼻咽喉科学会会報 (一社)日本耳鼻咽喉科学会 117 (4) 504 - 504 0030-6622 2014/04 [Not refereed][Not invited]
  • IgG4関連硬化性疾患に併発した副鼻腔炎
    高木 大, 中丸 裕爾, 鈴木 正宣, 本間 あや, 福田 諭
    耳鼻咽喉科免疫アレルギー 日本耳鼻咽喉科免疫アレルギー学会 31 (2) 73 - 74 0913-0691 2013/06 [Not refereed][Not invited]
  • Masanobu Suzuki, Yuji Nakamaru, Shigeru Akazawa, Takatsugu Mizumachi, Masanori Maeda, Dai Takagi, Kanako C. Hatanaka, Satoshi Fukuda
    LARYNGOSCOPE 123 (4) 829 - 834 0023-852X 2013/04 [Refereed][Not invited]
    Objectives/Hypothesis: Immunoglobulin (Ig)G4-related disease is a systemic syndrome, characterized by sclerosing lesions that mainly affect the exocrine tissue. Although some patients with IgG4-related disease complain of nasal symptoms, there are few reports concerning the nasal manifestations of this disease. We investigated the clinical and pathological features of the nasal manifestations of IgG4-related disease. Study Design: Retrospective review in a tertiary referral hospital. Methods: Twenty-three consecutive patients with IgG4-related disease, six allergic rhinitis (AR) patients, and eight healthy subjects (HS) were evaluated. Nasal symptoms, local findings of the nasal cavity, and laboratory data were examined. Mucosal tissues from the inferior turbinate were obtained from all subjects before treatment. The level of IgG4-positive plasma cells and other infiltrating cells, and the number of nasal glands in the nasal subjects were compared among the three groups. Results: Ten (43.4%) of 23 cases had some nasal symptoms, such as nasal obstruction and nasal crusting. Thirteen cases (56.5%) had numerous IgG4-positive plasma cell infiltration in the nasal mucosa. IgG4-positive plasma cells, CD3, and CD4 were significantly higher in the IgG4-related disease group than in the HS and AR groups, whereas the number of nasal glands in the IgG4-related disease group was significantly lower than in the HS and AR groups. Conclusions: The inflammatory lesions associated with IgG4-related disease exist on the nasal membrane. Thus, the nasal manifestations of IgG4-related disease were thought to be different from AR.
  • 急性副鼻腔炎に対するLevofloxacin 1日1回500mg投与の治療効果
    高木 大, 中丸 裕爾, 鈴木 正宣, 福田 諭
    耳鼻咽喉科・頭頸部外科 (株)医学書院 84 (13) 1021 - 1026 0914-3491 2012/12 [Not refereed][Not invited]
    急性副鼻腔炎に対するLevofloxacin 500mg1日1回投与の早期治療効果と安全性を検討した。解析対象は26症例で、急性炎症を起こしてから10日以内であり、投与期間は全て7日間であった。重症度は中等症6例、重症20例であった。投与開始3日後、自覚症状、他覚所見ともに有意なスコアの改善を認め、投与終了時の有効率は84.6%であり、特に重症例での有効率は90.0%であった。やや有効にとどまった症例を4例認めたが、自覚症状、他覚所見どちらも改善を示さない無効例はなかった。やや有効の4例中2例は、鼻中隔彎曲等による中鼻道の狭小化があり、その後内視鏡的副鼻腔手術を施行して改善した。24例には細菌学的検査を施行し、10例から12種の原因菌が同定された。Haemophilus influenzaeが5株と最多で、Streptococcus pneumoniaeの4株が続いた。副作用は1例に軽度の全身そう痒感が発現したが、内服は継続可能であった。
  • Dai Takagi, Yuji Nakamaru, Masanobu Suzuki, Satoshi Fukuda
    ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY 121 (12) 816 - 820 0003-4894 2012/12 [Refereed][Not invited]
    Objectives: We investigated the function of the decreases in histone deacetylase (HDAC) and histone acetyltransferase (HAT) in Wegener's granulomatosis (WG) patients compared with healthy subjects. Methods: Seven patients with WG, diagnosed according to the American College of Rheumatology criteria, were examined. Fresh peripheral blood mononuclear cells were isolated from the WG patients and healthy subjects, and then whole-cell proteins were prepared. We measured the total HDAC and HAT activity in peripheral blood mononuclear cells from WG patients. The HDAC2 expression was analyzed by Western blot. Results: We found that total HDAC activity was significantly decreased in WG patients compared to that in healthy subjects (p < 0.05). Furthermore, we found a negative correlation between total HDAC activity and C-reactive protein titer. Total HAT activity was significantly increased in WG patients. Conclusions: These results demonstrated reduced HDAC activity and an increase in HAT activity in WG. These were associated with concomitant induction of WG-related inflammation. Thus, dysregulation of HDAC and HAT may contribute to the disease pathogenesis of WG.
  • ヒストン脱アセチル化作用を有するSIRT1によるMMP-9の発現調節
    中丸 裕爾, 高木 大, 鈴木 正宣, 福田 諭
    耳鼻咽喉科免疫アレルギー 日本耳鼻咽喉科免疫アレルギー学会 30 (2) 215 - 216 0913-0691 2012/06 [Not refereed][Not invited]
  • ヒストンアセチル化がWegener肉芽腫症におよぼす影響について
    高木 大, 中丸 裕爾, 鈴木 正宣, 福田 諭
    耳鼻咽喉科免疫アレルギー 日本耳鼻咽喉科免疫アレルギー学会 30 (2) 76 - 77 0913-0691 2012/06 [Not refereed][Not invited]
  • IgG4関連疾患の鼻腔病変における組織学的検討
    鈴木 正宣, 中丸 裕爾, 赤澤 茂, 水町 貴諭, 前田 昌紀, 高木 大, 福田 諭
    耳鼻咽喉科免疫アレルギー 日本耳鼻咽喉科免疫アレルギー学会 30 (2) 70 - 71 0913-0691 2012/06 [Not refereed][Not invited]
  • 鈴木 正宣, 中丸 裕爾, 赤澤 茂, 水町 貴諭, 前田 昌紀, 高木 大, 福田 諭
    日本耳鼻咽喉科学会会報 (一社)日本耳鼻咽喉科学会 115 (4) 413 - 413 0030-6622 2012/04 [Not refereed][Not invited]
  • Modified Lothrop Procedureにより内視鏡的に切除した前頭洞内に茎を持つ内反性乳頭腫症例
    中丸 裕爾, 高木 大, 鈴木 正宣, 福田 諭
    日本鼻科学会会誌 (一社)日本鼻科学会 50 (3) 379 - 379 0910-9153 2011/11 [Not refereed][Not invited]
  • Shinya Morita, Masanobu Suzuki, Keiji Iizuka
    AURIS NASUS LARYNX 38 (5) 577 - 582 0385-8146 2011/10 [Refereed][Not invited]
    Objective: To heighten physician awareness of false-negative diffusion-weighted (DW) magnetic-resonance imaging findings in patients with acute cerebellar infarction and the importance of periodically observing nystagmus after symptom onset. Methods: Between April 2007 and March 2010, we retrospectively reviewed the medical records of eight patients who had all complained of severe isolated vertigo or dizziness, and had visited an emergency department within 2-6 h of its onset. Intracranial findings on initial magnetic resonance imaging (MRI) were normal. All patients had consulted our department for peripheral vestibular disorders. We periodically observed spontaneous and positional nystagmus 6-24 h after symptom onset. Results: In three of the patients, the direction and/or type of nystagmus changed periodically. In four of the patients, severe vertigo, nausea, and vomiting persisted after the nystagmus had been resolved. A repeat MR examination was performed 24 h after symptom onset because of the atypical pattern of nystagmus for benign peripheral vestibular disorders, at which point cerebellar infarction was detected. Conclusions: Physicians who examine patients with acute severe isolated vertigo or dizziness should consider the possibility of false-negative DW MRI findings in case of hyperacute ischemic stroke. It is important to observe the nystagmus periodically after onset. The MR examination should be repeated more than 24 h after symptom onset in patients with an atypical pattern of nystagmus for benign peripheral vestibular disorders. (c) 2011 Elsevier Ireland Ltd. All rights reserved.
  • Masanobu Suzuki, Takatsugu Mizumachi, Shinya Morita, Kanako Kubota, Keiji Iizuka
    JCR-JOURNAL OF CLINICAL RHEUMATOLOGY 17 (4) 207 - 210 1076-1608 2011/06 [Refereed][Not invited]
    This case study describes a 58-year-old man with watery eyes, bilateral swelling of the ala nasi and submandibular glands, and a swollen right parotid gland. Computed tomography revealed mass-forming lesions in both nasolacrimal ducts, extending bilaterally to the lacrimal sac and inferior meatus in the nose. Pathologic investigation showed marked infiltrates of immunoglobulin 4 (IgG4)-positive plasma cells in the nasolacrimal duct lesion, which led us to diagnose IgG4-related disease. Oral prednisolone improved the symptoms of watery eyes and the bilateral swelling of the nasolacrimal duct and salivary gland enlargement. To the best of our knowledge, this is the first report of IgG4-related disease involving mass-forming lesions in the nasolacrimal ducts.
  • 広頸筋皮弁を用いて再建した後期高齢者口腔癌の2症例
    鈴木 正宣, 蠣崎 文彦, 津布久 崇, 大谷 文雄, 松村 道哉, 沖田 美千子, 針谷 靖史, 関口 隆, 古田 康
    手稲渓仁会病院医学雑誌 (医)渓仁会手稲渓仁会病院 10 (1) 31 - 35 1343-3741 2011/03 [Not refereed][Not invited]
  • 垂直上眼瞼向き眼振が改善したWernicke脳症疑いの1例
    鈴木 正宣, 宮腰 浩世, 森田 真也, 飯塚 桂司
    市立釧路総合病院医学雑誌 市立釧路総合病院 23 (1) 93 - 96 0915-2520 2011/03 [Not refereed][Not invited]
    中枢性めまいを疑う典型的な眼振所見として垂直上眼瞼向き眼振があるが、稀であり、多数例をまとめた報告も少ない。今回我々はWernicke脳症が原因と考えられる垂直上眼瞼向き眼振が、経過と共に改善した1例を報告する。32歳男性。解離性遁走にて、屋外で倒れている状態で発見された。脱水、低栄養状態、見当識障害を認め、ビタミン剤を含む点滴療法が開始された。その後、歩行時のふらつきが残存し、当科紹介受診となった。初診時、右眼球の外転障害、複視と、頭位眼振検査にて急速相を上眼瞼向きに持つ垂直性の眼振を認めた。中枢性前庭障害と考え、神経内科を紹介し、見当識障害、失調性歩行、外眼筋麻痺、MRI所見からWernicke脳症と考えられた。その後、赤外線ビデオ眼球運動記録装置(video oculography:VOG)を用いて、経時的に観察したところ、垂直上眼瞼向き眼振の緩徐相速度の改善を認めた。自覚的にもふらつきやめまいなどの前庭障害は消失した。(著者抄録)
  • 異物の穿通により眼窩内血腫を呈した1例
    宮腰 浩世, 鈴木 正宣, 飯塚 桂司
    市立釧路総合病院医学雑誌 市立釧路総合病院 23 (1) 79 - 83 0915-2520 2011/03 [Not refereed][Not invited]
  • IgG4関連疾患が疑われた症例の検討
    鈴木 正宣, 宮腰 浩世, 森田 真也, 飯塚 桂司
    市立釧路総合病院医学雑誌 市立釧路総合病院 23 (1) 3 - 8 0915-2520 2011/03 [Not refereed][Not invited]
  • Shinya Morita, Kenji Mizoguchi, Masanobu Suzuki, Keiji Iizuka
    WORLD JOURNAL OF SURGERY 34 (11) 2564 - 2569 0364-2313 2010/11 [Refereed][Not invited]
    The aim of this study was to evaluate the accuracy of [(18)F]-fluoro-2-deoxy-d-glucose-positron emission tomography/computed tomography, ultrasonography, and enhanced computed tomography alone in the preoperative diagnosis of lymph node metastasis in patients with papillary thyroid carcinoma. In a prospective study performed between January 2007 and December 2009, 74 patients with a diagnosis of papillary thyroid carcinoma confirmed by fine-needle aspiration biopsy were referred to our institution for surgery. Preoperative assessment of metastasis in the central and lateral cervical lymph nodes was done using [(18)F]-fluoro-2-deoxy-d-glucose-positron emission tomography/computed tomography, ultrasonography, and enhanced computed tomography. The results for each level of cervical node assessed using these methods were correlated with the pathology reports after surgery. We determined the sensitivity, specificity, positive and negative predictive values, and diagnostic accuracy of the three methods for all levels of cervical lymph node. There were no significant differences in the diagnostic results obtained by [(18)F]-fluoro-2-deoxy-d-glucose-positron emission tomography/computed tomography and enhanced computed tomography. However, ultrasonography images gave significantly better results than either [(18)F]-fluoro-2-deoxy-d-glucose-positron emission tomography/computed tomography or enhanced computed tomography alone in identifying metastases on the basis of the level of cervical lymph node. In addition, the overall diagnostic accuracy tended to be higher for the lateral compartment than for the central compartment. Preoperative assessment by ultrasonography of metastases in the central and lateral cervical lymph nodes might be the best methodology for determining the extent of surgical resection required to remove metastatic lymph nodes adequately in patients with papillary thyroid carcinoma.
  • Masanobu Suzuki, Shinya Morita, Keiji Iizuka
    AURIS NASUS LARYNX 37 (4) 535 - 537 0385-8146 2010/08 [Refereed][Not invited]
    A 48-year-old female patient was seen in our institution complaining of sudden onset of swelling and tenderness in the left side of her neck. Computed tomography and magnetic resonance imaging revealed abundant effusions in this area. Since these narrowed the patient's airway, we performed incisional drainage and intra-operatively we observed a transparent, colorless lymph fluid that oozed from the operative field, which was mainly a fatty layer at the supraclavicular area. Dilated lymphatic ducts were seen along the carotid artery and internal jugular vein, but damaged lymphatic ducts and obvious causative disease structures like tumorous lesions were not seen. Idiopathic lymph leakage was diagnosed due to the serous discharge from the left side of the neck and no apparent causative disease. The patient was successfully treated with incisional drainage and dietary restriction. Lymph leakage in the neck is more common after trauma or surgery. To our knowledge, no similar cases have ever been reported. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
  • 反復性鼻出血に対する内視鏡下蝶口蓋動脈結紮術施行例の検討
    古田 康, 松村 道哉, 鈴木 正宣, 中丸 裕爾
    日本鼻科学会会誌 (一社)日本鼻科学会 49 (3) 415 - 415 0910-9153 2010/07 [Not refereed][Not invited]
  • Shinya Morita, Masanobu Suzuki, Keiji Iizuka
    INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY 74 (5) 441 - 446 0165-5876 2010/05 [Refereed][Not invited]
    Objective: The present study aimed to investigate the etiology, symptoms, diagnosis and prognosis of pediatric patients with non-organic hearing loss (NOHL), and to heighten awareness of this disorder among physicians. Methods: Between January 2000 and July 2009, we retrospectively reviewed the medical records of 47 pediatric patients (aged 6-18 years of age) diagnosed with NOHL. The diagnosis was made when there were audiometric discrepancies between the subjective and objective hearing thresholds of the patient in the absence of any organic disease. Results: Eighteen patients presented with unilateral hearing loss, and 29 showed bilateral hearing loss. Five patients received steroid treatment before the correct diagnosis was made, and six had secretory otitis media and underwent a tympanostomy tube placement. Conclusion: If physicians are unaware of the possibility of NOHL; they may misdiagnose children with idiopathic sudden sensorineural hearing loss and administer high-dose steroid treatments or exploratory tympanotomies. Otoacoustic emissions are abolished when NOHL patients have secretory otitis media. In these cases, after tympanostomy tube placement, they should undergo objective electrophysiologic examinations to reevaluate NOHL. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
  • 胸骨柄当該皮下に生じた類皮嚢胞の1例
    鈴木 正宣, 森田 真也, 飯塚 桂司
    市立釧路総合病院医学雑誌 市立釧路総合病院 22 (1) 89 - 92 0915-2520 2010/03 [Not refereed][Not invited]
    類皮嚢胞は、胎生期に外胚葉成分が中胚葉に迷入することに起因する、比較的稀な嚢胞性疾患である。身体各部に発生するが、頭頸部領域の発生率は全体の6.9%であり、その内の約20%が頸部に発生する。今回、我々は胸骨柄当該皮下に発生し、完全摘出した類皮嚢胞の1例を報告する。症例は41歳、男性。幼少期から両鎖骨間の皮下腫瘤に気づいていたが、徐々に増大したため、平成21年6月当科受診した。胸骨上部から下頸部正中の両鎖骨間に30mm大の皮下腫瘤があり、エコーでは、内部に点状のhigh echoが散在する嚢胞性腫瘤を認めた。類皮嚢胞の臨床診断にて、摘出術を行った。下頸部正中を横切開し、嚢胞壁にそって完全摘出した。摘出した嚢胞は4×3.5×4cmの円形で、表面平滑な皮膜を有していた。嚢胞を切開したところ、内部から乳白色のクリーミーな液体が流出し、嚢胞内には黒い毛髪が認められた。病理学的には、角化を伴う重層扁平上皮によって嚢胞壁内面が構成されており、壁内に皮脂腺、嚢胞腔内に毛髪を認め、類皮嚢胞と診断された。(著者抄録)
  • 後天性後鼻腔閉鎖症の1例
    鈴木 正宣, 森田 真也, 飯塚 桂司
    市立釧路総合病院医学雑誌 市立釧路総合病院 22 (1) 83 - 87 0915-2520 2010/03 [Not refereed][Not invited]
  • 気管支喘息と誤認された気管支異物の1例
    森田 真也, 鈴木 正宣, 飯塚 桂司
    市立釧路総合病院医学雑誌 市立釧路総合病院 22 (1) 77 - 81 0915-2520 2010/03 [Not refereed][Not invited]
    気道異物は呼吸困難を呈して低酸素血症から心停止に至る危険があるため、緊急性は非常に高い。今回、我々は異物を誤嚥した情報がないため気管支喘息と誤認された気管支異物症例を経験したので報告する。症例は5歳、男児で、咳嗽および喘鳴を主訴に近医小児科を受診して気管支喘息と診断された。気管支拡張薬・吸入にて治療されるも改善を認めなかったため、当院小児科を受診し、胸部単純X線写真にて右主気管支に異物を認めた。当科紹介となり、全身麻酔下にて換気孔付き硬性気管支鏡(ventilation bronchoscope)を挿入し、X線透視(術中イメージ)を併用することにより、硬性気管支鏡先端・異物鉗子・異物の位置を確認しながら摘出した。術中・術後合併症は認めず、経過良好にて術後4日で退院となった。(著者抄録)
  • 上顎癌に対する超選択的動注療法
    森田 真也, 鈴木 正宣, 稲村 茂, 今泉 俊雄, 飯塚 桂司
    市立釧路総合病院医学雑誌 市立釧路総合病院 22 (1) 11 - 17 0915-2520 2010/03 [Not refereed][Not invited]
  • 反復性鼻出血に対する内視鏡下蝶口蓋動脈結紮術施行例の検討
    鈴木 正宣, 大谷 文雄, 松村 道哉, 蠣崎 文彦, 森田 真也, 佐藤 宏紀, 中丸 裕爾, 古田 康
    耳鼻咽喉科・頭頸部外科 (株)医学書院 82 (1) 67 - 72 0914-3491 2010/01 [Not refereed][Not invited]
  • 古田 康, 松村 道哉, 大谷 文雄, 鈴木 正宣, 佐藤 宏紀, 森田 真也, 本間 明宏, 折舘 伸彦, 福田 諭
    日本耳鼻咽喉科学会会報 (一社)日本耳鼻咽喉科学会 113 (1) 9 - 14 0030-6622 2010/01 [Not refereed][Not invited]
    目的:化学放射線療法後の喉頭癌再発例に対する喉頭全摘出術においては、咽頭皮膚瘻孔など創合併症に発生率が高いことが報告されている。その予防策として、咽頭粘膜縫合部を血流に富む新鮮な組織で覆う方法(pharyngeal interposition graft)の有用性が報告されている。今回、喉頭癌に対する化学放射線療法後の再発例において、喉頭全摘出術とともに大胸筋弁をpharyngeal interposition graftとして用いた4症例の術後経過について検討した。対象:化学放射線療法後に再発を来した喉頭癌4症例(声門上癌3例、声門癌1例)を対象とした。喉頭全摘出術後、咽頭粘膜を一次縫合し、さらに咽頭粘膜縫合部と挙上した皮膚の間に大胸筋弁を挟みpharyngeal interposition graftとした。結果:4例中3症例に軽度創合併症が生じた。気管孔周囲の局所感染、皮下小膿瘍、皮膚縫合部の表層壊死が各1例であり、いずれも局所処置で改善した。4症例ともに咽頭皮膚瘻孔などの重度創合併症は来さなかった。また、大胸筋弁の血流不全および採取に伴う合併症は認められなかった。結論:大胸筋弁を用いたpharyngeal interposition graftは安全であり、化学放射線療法後の喉頭全摘出術において咽頭皮膚瘻孔などの重度創合併症の発生を抑えるため有用であると考えられた。(著者抄録)
  • Yasushi Furuta, Michiya Matsumura, Fumio Ohtani, Masanobu Suzuki, Hiroki Satoh, Shinya Morita, Akihiro Homma, Nobuhiko Oridate, Satoshi Fukuda
    Journal of Otolaryngology of Japan 113 (1) 9 - 14 0030-6622 2010 [Refereed][Not invited]
    There is an increased risk of wound complications in patients undergoing salvage laryngectomy following chemoradiotherapy. To reduce the rate of wound complications after a salvage total laryngectomy, a fresh tissue reinforcement of the pharyngeal suture line (pharyngeal interposition graft) has been reported to be useful. In the present study, wound complications after a salvage total laryngectomy with a pectoralis major muscle flap as a pharyngeal interposition graft were analyzed. Four patients with recurrent laryngeal cancer (three with supraglottis and one with glottic cancer) after chemoradiotherapy underwent salvage total laryngectomy using a pectoralis major muscle interposition flap. Minor wound complications were observed in three of the four patients, with an infection around the tracheostoma, a minor subcutaneous abscess, and a superficial skin necrosis in one patient each. These complications were managed with local wound care. No patients had major wound complications such as pharyngocutaneous fistulas. There were no necroses or wound complications of the pectoralis major muscle flap. This study has suggested that the pectoralis major muscle flap as a pharyngeal interposition graft is safe and useful for prevention of wound complications in salvage total laryngectomy following chemoradiotherapy.
  • Shinya Morita, Masanobu Suzuki, Keiji Iizuka
    ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES 72 (6) 295 - 299 0301-1569 2010 [Refereed][Not invited]
    Purpose of the Study: We aimed to compare the short-term outcome of patients with acute low-tone sensorineural hearing loss (ALHL) treated with steroid alone, diuretics alone or combination treatment. Procedures: Between April 2000 and March 2009, we retrospectively reviewed the medical records of 156 patients with a diagnosis of ALHL. All patients were followed up until improvement or for 8 weeks from the initial examination. Patients were treated with steroid alone (n = 49), diuretics alone (n = 40), combination treatment (n = 46) or they received neither steroid nor diuretics (n = 21). Results: The steroid-diuretic combination therapy for ALHL showed significantly better results than the steroid or diuretic treatments alone (p < 0.05). There were no clinically significant differences in the outcome between the steroid-and diuretic-alone treatments. Conclusion and Message: The etiology of ALHL is described as both an endolymphatic hydrops and an autoimmunological mechanism so that, as expected, the steroid-diuretic combination therapy was more effective than the steroid or diuretic treatments alone. Copyright (C) 2010 S. Karger AG, Basel
  • 【耳鼻咽喉科診療におけるヒヤリ・ハット】 治療過程におけるヒヤリ・ハット 口腔・咽頭の手術
    鈴木 正宣, 古田 康
    ENTONI (株)全日本病院出版会 (109) 53 - 61 1346-2067 2009/12 [Not refereed][Not invited]
  • 鈴木 正宣, 大谷 文雄, 松村 道哉, 古田 康
    日本気管食道科学会会報 (NPO)日本気管食道科学会 60 (6) 507 - 511 0029-0645 2009/12 [Not refereed][Not invited]
  • 咽喉頭酸逆流症に対するラベプラゾール投与による咽喉頭所見の検討(第2報)
    折舘 伸彦, 田口 亜紀, 渡嘉敷 亮二, 渡邊 雄介, 目須田 康, 鈴木 正宣, 新谷 朋子, 金泉 悦子, 丸子 文, 濱島 有喜, 吉岡 正展, 細川 清人, 後藤 理恵子, 印藤 加奈子, 山本 美佐子
    日本気管食道科学会会報 (NPO)日本気管食道科学会 60 (2) 210 - 210 0029-0645 2009/04 [Not refereed][Not invited]
  • 咽喉頭酸逆流症に対するラベプラゾール投与による咽喉頭所見の検討(第1報)
    田口 亜紀, 折館 伸彦, 渡嘉敷 亮二, 渡邊 雄介, 目須田 康, 鈴木 正宣, 新谷 朋子, 金泉 悦子, 丸子 文, 濱島 有喜, 吉岡 正展, 細川 清人, 後藤 理恵子, 印藤 加奈子, 山本 美佐子
    日本気管食道科学会会報 (NPO)日本気管食道科学会 60 (2) 168 - 168 0029-0645 2009/04 [Not refereed][Not invited]
  • 喉頭直達鏡下手術におけるコロラドマイクロディセクションニードルの使用経験
    鈴木 正宣, 大谷 文雄, 松村 道哉, 古田 康
    日本耳鼻咽喉科学会会報 (一社)日本耳鼻咽喉科学会 112 (4) 334 - 334 0030-6622 2009/04 [Not refereed][Not invited]
  • 眼球運動検査により経過を追えた家族性片麻痺性片頭痛I型の1例
    武市 紀人, 鈴木 正宣, 藤原 圭志, 津布久 崇, 福田 諭, 矢部 一郎, 佐々木 秀直
    日本耳鼻咽喉科学会会報 (一社)日本耳鼻咽喉科学会 112 (4) 300 - 300 0030-6622 2009/04 [Not refereed][Not invited]
  • 咽喉頭逆流症状に対するプロトンポンプ阻害剤投与による咽喉頭所見の検討(第3報)
    折舘 伸彦, 渡嘉敷 亮二, 渡邊 雄介, 田口 亜紀, 新谷 朋子, 金泉 悦子, 目須田 康, 鈴木 正宣, 丸子 文, 濱島 有喜, 吉岡 正展, 細川 清人, 後藤 理恵子, 印藤 加奈子, 山本 美佐子
    日本耳鼻咽喉科学会会報 (一社)日本耳鼻咽喉科学会 112 (4) 291 - 291 0030-6622 2009/04 [Not refereed][Not invited]
  • マイクロデブリッダーが有用であった成人型多発性喉頭乳頭腫の1症例
    鈴木 正宣, 折舘 伸彦, 本間 明宏, 中丸 裕爾, 畠山 博充, 目須田 康, 古田 康, 福田 諭
    耳鼻咽喉科・頭頸部外科 (株)医学書院 81 (3) 219 - 221 0914-3491 2009/03 [Not refereed][Not invited]
  • 治療経過を追えた家族性片麻痺性片頭痛I型の1例
    鈴木 正宣, 武市 紀人, 藤原 圭志, 津布久 崇, 福田 諭, 矢部 一郎, 佐々木 秀直
    Equilibrium Research (一社)日本めまい平衡医学会 67 (5) 411 - 411 0385-5716 2008/10 [Not refereed][Not invited]
  • 前縦隔発生の胚細胞腫瘍の一例
    鈴木 正宣, 吉田 貴之, 呉屋 裕樹, 秋江 研志, 小倉 滋明, 高田 明生
    市立札幌病院医誌 市立札幌病院 65 (2) 297 - 298 0288-6073 2005/12 [Not refereed][Not invited]
  • 当科における鼻腔癌の長期経過
    鈴木 正宣, 本杉 英昭, 永田 博史, 沼田 勉, 今野 昭義
    日本耳鼻咽喉科学会会報 (一社)日本耳鼻咽喉科学会 102 (9増刊) 1163 - 1163 0030-6622 1999/09 [Not refereed][Not invited]
  • 副鼻腔炎に続発した脳内膿瘍の1症例
    鈴木 正宣, 鈴木 誉, 佐内 明子, 内藤 準哉, 山口 宗彦, 丹野 裕和, 石毛 尚起
    日本耳鼻咽喉科学会会報 (一社)日本耳鼻咽喉科学会 102 (5増刊) 680 - 680 0030-6622 1999/05 [Not refereed][Not invited]


Research Grants & Projects

  • 好酸球性副鼻腔炎におけるSIRT1によるサイトカイン発現制御機序の解明
    Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists
    Date (from‐to) : 2018/04 -2022/03 
    Author : 鈴木 正宣
    本年度は、好酸球性副鼻腔炎で頻発する鼻ポリープに関するサイトカインであるMMP9のSIRT1による制御について検討した。 まず、鼻粘膜上皮初代継代細胞に、Poly(I:C)とSIRT1活性剤・阻害剤を投与し、qPCR法とELISA法にてMMP9の発現を確認した。Poly(I:C)によってMMP9が誘導されることが明らかになった。Poly(I:C)の投与がなければ、MMP9の発現はSIRT1活性剤・阻害剤に影響されなかったが、Poly(I:C)が投与された場合、SIRT1活性剤・阻害剤によってMMP9の発現が制御されることが明らかになった。またZymogram法で活性を評価したが、発現と同じく活性もSIRT1の活性剤・阻害剤にて変化することがわかった。 また、鼻茸を伴う副鼻腔炎、伴わない副鼻腔炎、健常例由来の鼻粘膜によって構成されたTissue micro arrayを使い、蛍光免疫染色法にてMMP9とSIRT1の発現の間の相関を確認した。また、MMP9とSIRT1の鼻粘膜局所発現部位について検討した。いずれも、SIRT1がMMP9の発現を制御することを示唆する結果であった。 MMP9はNFKBのターゲット遺伝子であることから、他のNFKBターゲット遺伝子にも同様の制御が存在する可能性がある。現在、SIRT1によって制御されている他のサイトカインを網羅的に検索するため、microfluidic qPCR法やMultiplex ELISA法にて検討を重ねている。
  • 細胞内亜鉛とTGF-βシグナル制御による好酸球性副鼻腔炎の新規治療法の開発
    Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
    Date (from‐to) : 2019 -2021 
    Author : 鈴木 正宣
  • 好酸球性副鼻腔炎の根治を施行したSIRT-1活性化剤の基礎的研究
    Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Research Activity start-up
    Date (from‐to) : 2017/08 -2019/03 
    Author : 鈴木 正宣
    本年度は、鼻粘膜上皮初代継代細胞(HNEC)を用いて、SIRT1によるサイトカイン発現制御を検討した。 まず、HNECにおける自然免疫シグナルを検討するため、TLR1-9のアゴニストをそれぞれ投与し、mRNAレベルでのサイトカイン発現を検討した。結果、TLR3のアゴニストであるPoly (I:C)によってサイトカイン発現が有意に亢進することがわかった。Poly(I:C)にはTLR3のみならずRIG-I受容体を介して自然免疫シグナルを活性化することがわかっている。RIG-IとTLR3の特異的アゴニストをそれぞれ用いて、サイトカインmRNAの発現を検討したところ、Poly(I:C)はTLR3を介してHNECの自然免疫シグナルを活性化させることが判明した。 次に、SIRT1の活性剤と抑制剤をPoly(I:C)とともにHNECに投与。サイトカインの一つであるMMP9のmRNA、蛋白質の発現、活性を評価した。SIRT1の活性剤はPoly(I:C)に誘導されるMMP9の発現、活性を抑制させた。逆に、SIRT1の抑制剤はPoly(I:C)に誘導されるMMP9の発現、活性を亢進させた。現在、他のサイトカインへのSIRT1の影響を、microfluidic qPCR法、multiplex ELISA法で網羅的に検討中である。 また、自然免疫シグナルにおけるSIRT1の発現変化を検討中である。これまでにqPCR法、蛍光抗体免疫染色法では自然免疫シグナルの活性化によりSIRT1がmRNAと蛋白質レベルで発現亢進していると示唆される結果を得ている。現在、SIRT1活性の測定を試みているところである。

Social Contribution

Social Contribution

Social Contribution

  • Advanced FESS course in Adelaide
    Date (from-to) : 2019/11/28
    Role : Lecturer
    Sponser, Organizer, Publisher  : Otolaryngology-Head and Neck surgery of Adelaide Univercity

Academic Contribution

  • 第2回臨床アレルギー講習会 講師
    Date (from-to) :2019/08/25
    Role: Others
    Type: Academic society etc
    Organizer, responsible person: 日本アレルギー学会
  • 第1回臨床アレルギー講習会 講師
    Date (from-to) :2018/09/02-2018/09/02
    Role: Others
    Type: Academic society etc
    Organizer, responsible person: 日本アレルギー学会

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