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Morita Ryo

Hokkaido University Hospital　Central Clinical FacilitiesAssistant Professor

Researcher basic information

■ Degree
  • 医学博士, Hokkaido University, Dec. 2019
■ URL
researchmap URLホームページURL■ Various IDs
Researcher number
  • 30872626
ORCID IDResearcher ID
  • AAX-4616-2020
J-Global ID■ Research Keywords and Fields
Research Field
  • Life Science, Radiological sciences, IVR
■ Educational Organization

Research activity information

■ Awards
  • Mar. 2024, 2023 JVIR Editor's Award Honoree | Distinguished Laboratory Investigation
    Mechanical Properties of 3D-Printed Transparent Flexible Resin Used for Vascular Model Simulation Compared with Porcine Arteries.
    森田亮
  • 2021, 北大・部局横断シンポジウム助成事業, Gold Award
    高難度医療技術のAIによる難易度解析と超高精細3D血管模型による非侵襲的技術継承を目指した基盤形成
  • 2021, RSNA, Certificate of Merit
    Percutaneous Drainage for Postoperative Fluid Collection after Hepato-Biliary Pancreatic Surgery
  • 2019, 北海道大学医学研究科, 堀田記念基金
■ Papers
  • Fiducial Marker Placement for Gated Radiotherapy Using Real-Time Tumor-Tracking in Pancreatic Cancer: A Comparative Analysis of Transarterial and Percutaneous Approaches
    Daisuke Kato; Daisuke Abo; Ryo Morita; Norio Katoh; Naoki Miyamoto; Ryota Yamada; Naoya Kinota; Takaaki Fujii; Kouji Yamasaki; Motoma Kanaya; Hidefumi Aoyama; Kohsuke Kudo
    Journal of Vascular and Interventional Radiology, Dec. 2025
    Scientific journal
  • Multidisciplinary surgical management with chemotherapy and transcatheter arterial embolization for a giant hypervascular pancreatic neuroendocrine tumor.
    Kokoro Niwa; Shintaro Takeuchi; Takahiro Tsuchikawa; Toru Nakamura; Satoshi Takeuchi; Ryo Morita; Daisuke Abo; Kenji Hirata; Tomoko Mitsuhashi; Satoshi Hirano
    Clinical journal of gastroenterology, 30 Sep. 2025, [Domestic magazines]
    English, Scientific journal, Pancreatic neuroendocrine tumors (pNETs) are rare and heterogeneous neoplasms occasionally presenting as giant, hypervascular, and anatomically complex tumors. In such cases, curative resection is often challenging, and multidisciplinary treatment is required. However, the clinical utility and optimal sequencing for these approaches remain unclear. We report a 39-year-old woman with a 130 mm hypervascular pNET occupying nearly the entire pancreas, complicated by portal vein tumor thrombus (PVTT) and extensive collateral circulation. The tumor was initially deemed unresectable by a multidisciplinary team. Streptozotocin (STZ)-based chemotherapy led to tumor regression and PVTT resolution. Preoperative transcatheter arterial embolization (TAE) was subsequently performed to reduce arterial inflow and facilitate surgical manipulation. Total pancreatectomy with segmental portal vein resection was successfully performed without transfusions. Histopathological examination confirmed a grade 2 pNET with a multifocal histological response which was consistent with radiological findings. The patient remained recurrence-free for 12 months postoperatively without adjuvant therapy. This case highlights the clinical utility of integrating STZ-based chemotherapy and selective TAE to achieve curative surgery for locally advanced giant pNETs. The unique clinical course and radiologic-pathologic correlation of this rare disease further contribute to the understanding of the treatment response.
  • A case of pediatric insulinoma misdiagnosed as atypical epilepsy for 4 years
    Rina Takano; Nozomi Hishimura; Naoya Kaneko; Megumi Endo; Takeshi Yamaguchi; Liu Zhitong; Yasuhisa Odagawa; Shohei Honda; Tatsuhiko Kakisaka; Insu Kawahara; Daisuke Kato; Ryo Morita; Daisuke Abo; Ayumi Takayanagi; Akie Nakamura; Atsushi Manabe; Kiyoshi Egawa; Shuntaro Morikawa
    Brain and Development Case Reports, 3, 3, 100084, 100084, Elsevier BV, Sep. 2025
    Scientific journal
  • Two cases of bronchial artery aneurysms in patients with long-standing precapillary pulmonary hypertension
    Taku Komori; Takahiro Sato; Ichizo Tsujino; Daisuke Tamatsuki; Shuhei Yoshikawa; Hideki Shima; Junichi Nakamura; Ryo Morita; Daisuke Abo; Satoshi Konno
    Respiratory Investigation, 63, 4, 521, 523, Jul. 2025, [International Magazine]
    English, Scientific journal, Bronchial artery aneurysm (BAA) is a rare but increasingly recognized condition due to advances in imaging. We report two cases of BAA in patients with long-standing pulmonary hypertension. Case 1 is a 30-year-old man with idiopathic peripheral pulmonary artery stenosis diagnosed at age 23. He developed a slightly dilated bronchial artery, which later enlarged, leading to bronchial artery embolization. Case 2 is a 30-year-old woman with pulmonary arterial hypertension diagnosed at age 3. Multiple BAAs were identified at age 24, and progressive enlargement was observed at age 28. Due to lesion complexity, she remains under careful observation.
  • Patient-specific vascular models for optimal catheter selection: Two aneurysm embolization cases
    Ryo Morita; Daisuke Abo; Takaaki Fujii; Naoya Kinota; Daisuke Kato; Kouji Yamasaki; Motoma Kanaya; Taisuke Harada; Osamu Sugita; Norio Kawamura; Akinobu Taketomi; Kohsuke Kudo
    Radiology Case Reports, 20, 6, 2813, 2819, Jun. 2025, [International Magazine]
    English, Scientific journal, Patient-specific vascular models enhance preoperative planning in interventional radiology, particularly in complex and anatomically challenging cases. This report presents two cases of complex aneurysm coil embolization in which three-dimensional, printed, patient-specific vascular hollow models were key to selecting optimal catheters, leading to successful interventions. Preoperative simulations with these models facilitated preselection of the optimal catheter, minimizing the need for intraoperative catheter exchange and reducing the time required for catheter engagement and placement. This approach improves procedural efficiency and outcomes by ensuring a smoother workflow.
  • Effect of a Training System Utilizing 3-Dimensionally Printed Patient-Specific Vascular Models on Endovascular Catheterization Performance
    Ryo Morita; Yo Kurashima; Takeshi Soyama; Daisuke Abo; Noriyuki Fujima; Takuto Kameda; Bunya Takahashi; Naoya Kinota; Daisuke Kato; Takaaki Fujii; Hiroyuki Hamaguchi; Kohsuke Kudo
    Journal of Vascular and Interventional Radiology, 36, 5, 901, 907, May 2025, [International Magazine]
    English, Scientific journal, This study aimed to determine the effect of simulation training using a 3-dimensionally (3D) printed patient-specific vascular model on the advanced vascular catheterization skills of experienced interventional radiologists. Two specific anatomical types of 3D-printed patient-specific models from 2 patients with challenging celiac axis arterial anatomy were constructed. The Global Rating Scale of Endovascular Performance (GRS-EP) was used to evaluate vascular insertion skills. The training sessions comprised pretraining and posttraining evaluations. Two blinded raters evaluated the effectiveness of the training. Improvements were observed in success rate, insertion time, and GRS-EP scores among all 5 experienced interventonial radiologists. The GRS-EP demonstrated high interrater reliability. Posttraining scores increased significantly in both video and self-evaluations. Although there is no proof that better performance on this type of model directly translates to improved performance in humans, simulation training using this model has the potential to help experienced interventional radiologists further refine their vascular catheterization skills.
  • Improvement of Hypoalbuminemia and Hepatic Reserve after Stent Placement for Postsurgical Portal Vein Stenosis
    Naoya Kinota; Daisuke Abo; Ryo Morita; Koji Yamasaki; Takaaki Fujii; Daisuke Kato; Tasuku Kimura; Yusuke Sakuhara; Kazufumi Okada; Isao Yokota; Tatsuya Orimo; Tatsuhiko Kakisaka; Toru Nakamura; Satoshi Hirano; Kazuyuki Minowa; Kohsuke Kudo
    Journal of Vascular and Interventional Radiology, 36, 4, 616, 624, Apr. 2025, [International Magazine]
    English, Scientific journal, PURPOSE: To investigate the change in serum albumin (Alb) levels and hepatic reserve scores before and after portal vein stent placement (PVS) for postsurgical portal vein (PV) stenosis. MATERIALS AND METHODS: A retrospective cohort of patients who underwent PVS after abdominal surgery between 2007 and 2021 was analyzed. Patients' age, sex, and PVS technical success (defined by PV patency at final portography) were evaluated. Alb, prothrombin time-international ratio (PT-INR), total bilirubin (Tbili), platelet (Plt) counts, Child-Pugh scores (CPS), and Alb-bilirubin (ALBI) scores/grades before and 1 month after PVS were compared. Normally distributed variables were summarized as mean ± standard deviation (SD) and compared with paired t-tests. Skewed variables were summarized as median (interquartile range) and compared with the signed-rank tests. RESULTS: Twenty-five patients (mean age, 61 years [SD ± 10]; female, 44%) were included. Technical success of PVS was achieved in all. Comparison was conducted for 28 PVS sessions: the Alb levels increased from 3.1 g/dL (SD ± 0.6) to 3.5 g/dL (SD ± 0.5) (P = .006), with greatest change in patients with pre-PVS Alb levels of ≤2.9 g/dL (2.6 g/dL ± 0.3 to 3.3 g/dL ± 0.4, P < .001). Improvements in CPS (P = .026), ALBI score (P = .002), and ALBI grades (P = .026) were observed. PT-INR elongated (1.2 [1.1-1.3] to 1.3 [1.2-1.6], P = .002), mainly because of patients receiving post-PVS warfarin (P = .005 and P = .20 for with and without warfarin, respectively). No significant changes were observed for Tbili (P = .40) and Plt counts (P = .25). CONCLUSIONS: Improvements of liver synthetic function represented by serum Alb levels and in hepatic reserve scores were observed after PVS, particularly in patients with pre-PVS hypoalbuminemia.
  • 血管系IVRシミュレーションに適した3Dプリントによる透明柔軟な樹脂を用いた血管モデルの可能性
    森田 亮; 野々山 貴行; 阿保 大介; 曽山 武士; 藤間 憲幸; 今井 哲秋; 高橋 文也; 木野田 直也; 加藤 大祐; 藤井 宝顕; 山崎 康之; 高柳 歩; 濱口 裕行; 亀田 拓人; 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌, 39, Suppl., 253, 253, (一社)日本インターベンショナルラジオロジー学会, Apr. 2024
    Japanese
  • 膵癌に対する動体追跡放射線治療用の経皮的あるいは経動脈的マーカー留置術の検討
    加藤 大祐; 阿保 大介; 森田 亮; 打浪 雄介; 加藤 徳雄; 山田 亮太; 木野田 直也; 藤井 宝顕; 山崎 康之; 高柳 歩; 青山 英史; 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌, 39, Suppl., 191, 191, (一社)日本インターベンショナルラジオロジー学会, Apr. 2024
    Japanese
  • 膵癌に対する動体追跡放射線治療用の経皮的あるいは経動脈的マーカー留置術の検討
    加藤 大祐; 阿保 大介; 森田 亮; 打浪 雄介; 加藤 徳雄; 山田 亮太; 木野田 直也; 藤井 宝顕; 山崎 康之; 高柳 歩; 青山 英史; 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌, 39, Suppl., 191, 191, (一社)日本インターベンショナルラジオロジー学会, Apr. 2024
    Japanese
  • 血管系IVRシミュレーションに適した3Dプリントによる透明柔軟な樹脂を用いた血管モデルの可能性
    森田 亮; 野々山 貴行; 阿保 大介; 曽山 武士; 藤間 憲幸; 今井 哲秋; 高橋 文也; 木野田 直也; 加藤 大祐; 藤井 宝顕; 山崎 康之; 高柳 歩; 濱口 裕行; 亀田 拓人; 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌, 39, Suppl., 253, 253, (一社)日本インターベンショナルラジオロジー学会, Apr. 2024
    Japanese
  • 3Dプリント患者個別血管モデルを用いた最適なカテーテル選択 動脈瘤コイル塞栓術の2例
    森田 亮; 阿保 大介; 藤井 宝顕; 木野田 直也; 加藤 大祐; 山崎 康之; 高柳 歩; 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌, 39, Suppl., 260, 260, (一社)日本インターベンショナルラジオロジー学会, Apr. 2024
    Japanese
  • 経皮的門脈塞栓術前後門脈4D-flow MRIの評価者間再現性に関する初期検討
    木野田 直也; 阿保 大介; 高柳 歩; 山崎 康之; 藤井 宝顕; 加藤 大祐; 森田 亮; 箕輪 和行; 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌, 39, Suppl., 299, 299, (一社)日本インターベンショナルラジオロジー学会, Apr. 2024
    Japanese
  • 当院において経皮経脾静脈アプローチによるIVRを施行した2例
    高柳 歩; 阿保 大介; 森田 亮; 高橋 文也; 木野田 直也; 加藤 大祐; 藤井 宝顕; 山崎 康之; 中西 喜嗣; 荘 拓也; 中井 正人; 平野 聡; 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌, 39, Suppl., 304, 304, (一社)日本インターベンショナルラジオロジー学会, Apr. 2024
    Japanese
  • Treatment of delayed pancreatic fistula associated with anastomosis breakdown after pancreaticoduodenectomy using percutaneous interventions.
    Reimi Suzuki; Yuji Konishi; Kai Makino; Yosuke Wakui; Kazuhiro Mino; Hideki Kawamura; Ryo Morita; Tatsuhiko Kakisaka; Daisuke Abo; Akinobu Taketomi
    Clinical journal of gastroenterology, 17, 2, 356, 362, Apr. 2024, [Domestic magazines]
    English, Scientific journal, We here present a rare case of development of a postoperative pancreatic fistula and breakdown of the pancreaticojejunal anastomosis 8 months after pancreaticoduodenectomy. A 70-year-old man underwent pancreaticoduodenectomy for distal cholangiocarcinoma and initially recovered well. However, 8 months later, he developed abdominal pain and distention and was admitted to our institution with suspected pancreatitis. On the 17th day of hospitalization, he suddenly bled from the jejunal loop and a fluid collection was detected near the pancreaticojejunal anastomosis site. The fluid collection was drained percutaneously. Subsequent fistulography confirmed breakdown of the pancreaticojejunal anastomosis. Considering the patient's overall condition and the presence of postoperative adhesions, we decided to manage him conservatively. An additional drain tube was placed percutaneously from the site of the anastomotic breakdown into the lumen of the jejunum, along with the tube draining the fluid collection, creating a completely new fistula. This facilitated the flow of pancreatic fluid into the jejunum and was removed 192 days after placement. During a 6-month follow-up, there were no recurrences of pancreatitis or a pancreatic fistula. This case highlights the efficacy of percutaneous drainage and creation of an internal fistula as a management strategy for delayed pancreatic fistula and anastomotic breakdown following pancreaticoduodenectomy.
  • SSPPD後の胆管空腸吻合部閉塞に対するsharp recanalizationによる内外瘻化
    岡村 実幸; 阿保 大介; 森田 亮; 松井 あや; 木野田 直也; 加藤 大祐; 藤井 宝顕; 山崎 康之; 高柳 歩; 若林 直人; 平野 聡; 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌, 38, 3, 221, 221, (一社)日本インターベンショナルラジオロジー学会, Jan. 2024
    Japanese
  • 【癌の診断・治療・緩和におけるIVR:日常診療に役立つtips】診断・治療支援 定位放射線治療用マーカー留置
    森田 亮; 阿保 大介
    臨床放射線, 68, 13, 1415, 1421, 金原出版(株), Dec. 2023
    Japanese
  • 【癌の診断・治療・緩和におけるIVR:日常診療に役立つtips】診断・治療支援 術前門脈塞栓術
    阿保 大介; 森田 亮
    臨床放射線, 68, 13, 1435, 1439, 金原出版(株), Dec. 2023
    Japanese
  • 【癌の診断・治療・緩和におけるIVR:日常診療に役立つtips】診断・治療支援 定位放射線治療用マーカー留置
    森田 亮; 阿保 大介
    臨床放射線, 68, 13, 1415, 1421, 金原出版(株), Dec. 2023
    Japanese
  • 【癌の診断・治療・緩和におけるIVR:日常診療に役立つtips】診断・治療支援 術前門脈塞栓術
    阿保 大介; 森田 亮
    臨床放射線, 68, 13, 1435, 1439, 金原出版(株), Dec. 2023
    Japanese
  • Real-time tumor-tracking radiotherapy with SyncTraX for primary liver tumors requiring isocenter shift†.
    Yusuke Uchinami; Naoki Miyamoto; Daisuke Abo; Ryo Morita; Koji Ogawa; Tatsuhiko Kakisaka; Ryusuke Suzuki; Tomohiko Miyazaki; Hiroshi Taguchi; Norio Katoh; Hidefumi Aoyama
    Journal of radiation research, 22 Nov. 2023, [International Magazine]
    English, Scientific journal, The SyncTraX series enables real-time tumor-tracking radiotherapy through the real-time recognition of a fiducial marker using fluoroscopic images. In this system, the isocenter should be located within approximately 5-7.5 cm from the marker, depending on the version, owing to the limited field of view. If the marker is placed away from the tumor, the isocenter should be shifted toward the marker. This study aimed to investigate stereotactic body radiotherapy (SBRT) outcomes of primary liver tumors treated with SyncTraX in cases where the isocenter was shifted marginally or outside the planning target volume (PTV). Twelve patients with 13 liver tumors were included in the analysis. Their isocenter was shifted toward the marker and was placed marginally or outside the PTV. The prescribed doses were generally 40 Gy in four fractions or 48 Gy in eight fractions. The overall survival (OS) and local control (LC) rates were calculated using the Kaplan-Meier method. All patients completed the scheduled SBRT. The median distance between the fiducial marker and PTV centroid was 56.0 (interquartile range [IQR]: 52.7-66.7) mm. By shifting the isocenter toward the marker, the median distance between the marker and isocenter decreased to 34.0 (IQR: 33.4-39.7) mm. With a median follow-up period of 25.3 (range: 6.9-70.0) months, the 2-year OS and LC rates were 100.0% (95% confidence interval: 100-100). An isocenter shift makes SBRT with SyncTraX feasible in cases where the fiducial marker is distant from the tumor.
  • 耐え難い術後感染性合併症を乗り越えるためのIVR 胆管空腸吻合部狭窄に対するPTBDチューブ留置法の工夫
    阿保 大介; 森田 亮; 木野田 直也; 加藤 大祐; 藤井 宝顕; 山崎 康之; 高柳 歩; 工藤 與亮
    日本外科感染症学会雑誌, 20, 3, 289, 289, (一社)日本外科感染症学会, Nov. 2023
    Japanese
  • 耐え難い術後感染性合併症を乗り越えるためのIVR 胆管空腸吻合部狭窄に対するPTBDチューブ留置法の工夫
    阿保 大介; 森田 亮; 木野田 直也; 加藤 大祐; 藤井 宝顕; 山崎 康之; 高柳 歩; 工藤 與亮
    日本外科感染症学会雑誌, 20, 3, 289, 289, (一社)日本外科感染症学会, Nov. 2023
    Japanese
  • 慢性腎臓病を合併したFGF23関連低リン血症性骨軟化症の一例
    大西 錦之介; 亀田 啓; 宮 愛香; 野本 博司; 中村 昭伸; 松岡 正剛; 森田 亮; 渥美 達也
    日本内分泌学会雑誌, 99, 2, 609, 609, (一社)日本内分泌学会, Oct. 2023
    Japanese
  • 短絡路温存門脈-大循環分流術および傍臍静脈塞栓術が有用であった肝硬変合併シャント型肝性脳症の1例
    久居 弘幸; 櫻井 環; 小柴 裕; 飴田 咲貴; 鈴木 慎人; 森田 亮; 木野田 直也; 阿保 大介
    日本門脈圧亢進症学会雑誌, 29, 3, 121, 121, (一社)日本門脈圧亢進症学会, Aug. 2023
    Japanese
  • 短絡路温存門脈-大循環分流術および傍臍静脈塞栓術が有用であった肝硬変合併シャント型肝性脳症の1例
    久居 弘幸; 櫻井 環; 小柴 裕; 飴田 咲貴; 鈴木 慎人; 森田 亮; 木野田 直也; 阿保 大介
    日本門脈圧亢進症学会雑誌, 29, 3, 121, 121, (一社)日本門脈圧亢進症学会, Aug. 2023
    Japanese
  • Blockage of CSF Outflow in Rats after Deep Cervical Lymph Node Ligation Observed Using Gd-based MR Imaging.
    Naoya Kinota; Hiroyuki Kameda; Bai Xiawei; Takaaki Fujii; Daisuke Kato; Bunya Takahashi; Ryo Morita; Daisuke Abo; Ryusei Majima; Hiroshi Ishii; Kazuyuki Minowa; Kohsuke Kudo
    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine, 30 May 2023, [Domestic magazines]
    English, Scientific journal, PURPOSE: To investigate whether deep cervical lymph node (DCLN) ligation alters intracranial cerebrospinal fluid (CSF) tracer dynamics and outflow using a rat model with intrathecal dynamic contrast-enhanced (DCE) MRI. METHODS: Six bilateral DCLN-ligated and six sham-operated rats were subjected to DCE MRI with Gd-BTDO3A, and dynamic T1-weighted images were acquired. ROIs were collected from the CSF at the C1 level (CSF_C1), CSF between the olfactory bulbs (CSF_OB), CSF at the pituitary recess (CSF_PitR), and CSF at the pineal recess (CSF_PinR), upper nasal turbinate (UNT), olfactory bulbs, cerebrum, and the jugular region. Time-intensity curves were evaluated, and the maximum slope, peak timing, peak signal ratio, and elimination half-life for the four CSF ROIs and UNT were calculated and compared. RESULTS: Delayed tracer arrival in the rostral CSF space and the nasal cavity with tracer retention in the ventral CSF space were observed in the ligation group. The maximum slopes were smaller in the ligation group at UNT (sham: 0.075 ± 0.0061, ligation: 0.044 ± 0.0086/min, P = 0.011). A significant difference was not detected in peak timings. The peak signal ratio values were lower in the ligation group at UNT (sham: 2.12 ± 0.19, ligation: 1.72 ± 0.11, P = 0.011). The elimination half-life was delayed in the ligation group at CSF_C1 (sham: 30.5 ± 2.70, ligation: 44.4 ± 12.6 min, P = 0.043), CSF_OB (sham: 30.2 ± 2.67, ligation: 44.8 ± 7.47 min, P = 0.021), and CSF_PitR (sham: 30.2 ± 2.49, ligation: 41.3 ± 7.57 min, P = 0.021). CONCLUSION: The DCLN ligation in rats blocked CSF outflow into the nasal cavity and caused CSF retention.
  • 腹部手術後門脈狭窄/閉塞に対する門脈ステント留置による血液検査データ変化に関する検討
    木野田 直也; 阿保 大介; 木村 輔; 作原 祐介; 藤井 宝顕; 加藤 大祐; 高橋 文也; 森田 亮; 折茂 達也; 柿坂 達彦; 中村 透; 平野 聡; 箕輪 和行; 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌, 38, Suppl., 205, 205, (一社)日本インターベンショナルラジオロジー学会, Apr. 2023
    Japanese
  • 肝左葉尾状葉切除術後の門脈狭窄、右肝動脈出血に対しstentgraft留置が奏功した一例
    村本 朋之; 阿保 大介; 森田 亮; 高橋 文也; 木野田 直也; 加藤 大祐; 藤井 宝顕; 田中 公貴; 中西 喜嗣; 野路 武寛; 平野 聡; 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌, 38, Suppl., 205, 205, (一社)日本インターベンショナルラジオロジー学会, Apr. 2023
    Japanese
  • 高精細3D血管モデルを用いた術前シミュレーションの有用性(The usefulness of preoperative simulation with 3D-printed patient-specific hollow vascular models)
    森田 亮; 阿保 大介; 曽山 武士; 今井 哲秋; 高橋 文也; 吉野 裕紀; 木野田 直也; 加藤 大祐; 藤井 宝顕; 濱口 裕行; 亀田 拓人; 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌, 38, Suppl., 236, 236, (一社)日本インターベンショナルラジオロジー学会, Apr. 2023
    English
  • 4D-flow MRIを用いたportosystemic shunt閉塞前後の門脈血流評価
    加藤 大祐; 阿保 大介; 木野田 直也; 常田 慧徳; 石坂 欣也; 森田 亮; 高橋 文也; 藤井 宝顕; 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌, 38, Suppl., 237, 237, (一社)日本インターベンショナルラジオロジー学会, Apr. 2023
    Japanese
  • 肝エキノコックス症による右肝静脈狭窄に対してcovered stentを留置した一例
    渡辺 祈一; 阿保 大介; 森田 亮; 木野田 直也; 高橋 文也; 加藤 大祐; 藤井 宝顕; 柿坂 達彦; 折茂 達也; 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌, 38, Suppl., 277, 277, (一社)日本インターベンショナルラジオロジー学会, Apr. 2023
    Japanese
  • 腹部手術後門脈狭窄/閉塞に対する門脈ステント留置による血液検査データ変化に関する検討
    木野田 直也; 阿保 大介; 木村 輔; 作原 祐介; 藤井 宝顕; 加藤 大祐; 高橋 文也; 森田 亮; 折茂 達也; 柿坂 達彦; 中村 透; 平野 聡; 箕輪 和行; 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌, 38, Suppl., 205, 205, (一社)日本インターベンショナルラジオロジー学会, Apr. 2023
    Japanese
  • 肝左葉尾状葉切除術後の門脈狭窄、右肝動脈出血に対しstentgraft留置が奏功した一例
    村本 朋之; 阿保 大介; 森田 亮; 高橋 文也; 木野田 直也; 加藤 大祐; 藤井 宝顕; 田中 公貴; 中西 喜嗣; 野路 武寛; 平野 聡; 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌, 38, Suppl., 205, 205, (一社)日本インターベンショナルラジオロジー学会, Apr. 2023
    Japanese
  • 高精細3D血管モデルを用いた術前シミュレーションの有用性(The usefulness of preoperative simulation with 3D-printed patient-specific hollow vascular models)
    森田 亮; 阿保 大介; 曽山 武士; 今井 哲秋; 高橋 文也; 吉野 裕紀; 木野田 直也; 加藤 大祐; 藤井 宝顕; 濱口 裕行; 亀田 拓人; 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌, 38, Suppl., 236, 236, (一社)日本インターベンショナルラジオロジー学会, Apr. 2023
    English
  • 4D-flow MRIを用いたportosystemic shunt閉塞前後の門脈血流評価
    加藤 大祐; 阿保 大介; 木野田 直也; 常田 慧徳; 石坂 欣也; 森田 亮; 高橋 文也; 藤井 宝顕; 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌, 38, Suppl., 237, 237, (一社)日本インターベンショナルラジオロジー学会, Apr. 2023
    Japanese
  • 肝エキノコックス症による右肝静脈狭窄に対してcovered stentを留置した一例
    渡辺 祈一; 阿保 大介; 森田 亮; 木野田 直也; 高橋 文也; 加藤 大祐; 藤井 宝顕; 柿坂 達彦; 折茂 達也; 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌, 38, Suppl., 277, 277, (一社)日本インターベンショナルラジオロジー学会, Apr. 2023
    Japanese
  • Mechanical Properties of 3D-Printed Transparent Flexible Resin Used for Vascular Model Simulation Compared with Porcine Arteries.
    Ryo Morita; Takayuki Nonoyama; Daisuke Abo; Takeshi Soyama; Fujima Noriyuki; Tetsuaki Imai; Hiroyuki Hamaguchi; Takuto Kameda; Osamu Sugita; Bunya Takahashi; Naoya Kinota; Kohsuke Kudo
    Journal of vascular and interventional radiology : JVIR, 34, 5, 871, 878, 13 Jan. 2023, [Peer-reviewed], [International Magazine]
    English, Scientific journal, PURPOSE: To develop a vascular intervention simulation model that replicates the characteristics of a human patient, the mechanical properties of a three-dimensional (3D)- printed transparent flexible resin were compared with those of porcine arteries using the elastic modulus (E) and kinetic friction coefficient (μ_k). MATERIALS AND METHODS: Resin plates were created from transparent flexible resin using a 3D printer. Porcine artery plates were prepared by excising the aorta. E, adhesive strength of resin and arterial surface toward polyethylene plate, was measured with a tensile-compressive mechanical tester. The resin transparency was measured with an ultraviolet-visible light spectrometer. μ_k of the resin plate surface after applying silicone spray for 1-5 s and that of the artery were measured with a translational friction tester. RESULTS: E differed significantly between the arteries and resin plates at each curing time (0.20 ±0.04 vs. 8.53 ±2.37 MPa for a curing time of 1 min, P<0.05). The resin was stiffer than the arteries, regardless of the curing times. The visible light transmittance and adhesive strength of the resin decreased as the curing time increased. The adhesive strength of the artery was the lowest. μ_k of the silicone-coated resin surface created by applying silicone for 2-3 s (thickness of the silicone layer: 1.6-2 μm) was comparable with that of the artery, indicating that the coating imparted a similar slippage to the resin as the living artery. CONCLUSION: Transparent flexible resin is useful for creating a transparent and slippery vascular model for vascular intervention simulation.
  • Study of hepatic toxicity in small liver tumors after photon or proton therapy based on factors predicting the benefits of proton.
    Yusuke Uchinami; Norio Katoh; Daisuke Abo; Ryo Morita; Hiroshi Taguchi; Yoshihiro Fujita; Takahiro Kanehira; Ryusuke Suzuki; Naoki Miyamoto; Seishin Takao; Taeko Matsuura; Takuya Sho; Koji Ogawa; Tatsuya Orimo; Tatsuhiko Kakisaka; Keiji Kobashi; Hidefumi Aoyama
    The British journal of radiology, 96, 1144, 20220720, 20220720, 12 Jan. 2023, [International Magazine]
    English, Scientific journal, OBJECTIVES: In a previous study of hepatic toxicity, the following three factors were identified to predict the benefits of proton beam therapy (PBT) for hepatocellular carcinomas (HCC) with a maximum diameter of ≤5 cm and Child-pugh grade A (CP-A): number of tumors (one vs ≥2), the location of tumors (hepatic hilum or others), and the sum of the diameters of lesions. The aim of this study is to analyze the association between these three factors and hepatic toxicity. METHODS: We retrospectively reviewed patients of CP-A treated with PBT or photon stereotactic body radiotherapy (X-ray radiotherapy, XRT) for HCC ≤5 cm. For normal liver dose, the V5, V10, V20 (volumes receiving 5, 10, and 20 Gy at least), and the mean dose was evaluated. The albumin-bilirubin (ALBI) and CP score changes from the baseline were evaluated at 3 and 6 months after treatment. RESULTS: In 89 patients (XRT: 48, PBT: 41), those with two or three (2-3) predictive factors were higher normal liver doses than with zero or one (0-1) factor. In the PBT group, the ALBI score worsened more in patients with 2-3 factors than those with 0-1 factor, at 3 months (median 0.26 vs 0.02, p = 0.032) and at 6 months (median: 0.35 vs 0.10, p = 0.009). The ALBI score change in the XRT group and CP score change in either modality were not significantly different in the number of predictive factors. CONCLUSIONS: The predictive factor numbers predicted the ALBI score change in PBT but not in XRT. ADVANCES IN KNOWLEDGE: This study suggest that the number of predictive factors previously identified (0-1 vs 2-3) were significantly associated with dosimetric parameters of the normal liver in both modalities. In the proton group, the number of predictive factors was associated with a worsening ALBI score at 3 and 6 months, but these associations were not found in the photon SBRT group.
  • Percutaneous Drainage for Postoperative Fluid Collection after Hepatobiliary Pancreatic Surgery.
    Ryo Morita; Daisuke Abo; Taisuke Harada; Takeshi Soyama; Bunya Takahashi; Yuki Yoshino; Naoya Kinota; Taichi Yasui; Kohsuke Kudo
    Radiographics : a review publication of the Radiological Society of North America, Inc, 42, 6, E171-E172, Oct. 2022, [International Magazine]
    English, Scientific journal
  • Usefulness of preoperative simulation with patient-specific hollow vascular models for high-flow renal arteriovenous fistula embolization using a preloading coil-in-plug technique.
    Ryo Morita; Daisuke Abo; Takeshi Soyama; Tetsuaki Imai; Bunya Takahashi; Yuki Yoshino; Naoya Kinota; Hiroyuki Hamaguchi; Takuto Kameda; Kohsuke Kudo
    Radiology case reports, 17, 10, 3578, 3586, Oct. 2022, [International Magazine]
    English, The development of three-dimensional printers has facilitated the creation of patient-specific hollow vessel models. Preoperative simulations using these types of models have improved our ability to select appropriate devices and embolic materials before performing complex endovascular procedures. This report describes 2 cases of high-flow renal arteriovenous fistulas (r-AVFs) that were successfully treated via short-segment embolization using the preloading coil-in-plug (p-CIP) technique. To our knowledge, this is the first report of r-AVF being treated using the p-CIP technique. Our findings demonstrate that preoperative simulation has the potential to improve the safety and reliability of complex vascular embolization procedures.
  • An Adult Case of Unilateral Left Pulmonary Artery Agenesis Presenting with Hemoptysis.
    Yuriko Ishida; Masaru Suzuki; Hiroshi Horii; Junichi Nakamura; Munehiro Matsumoto; Sho Nakakubo; Takahiro Sato; Ichizo Tsujino; Ryo Morita; Daisuke Abo; Satoshi Konno
    Internal medicine (Tokyo, Japan), 62, 5, 763, 767, 22 Jul. 2022, [Domestic magazines]
    English, Scientific journal, Pulmonary artery agenesis (PAA) is a rare congenital vascular anomaly usually diagnosed during infancy. We herein report a 67-year-old man with PAA manifesting as massive hemoptysis. Contrast-enhanced computed tomography of the chest revealed the diagnosis of PAA, which we speculated to have resulted in the present event. Detailed angiography provided more accurate information on the pulmonary vasculature and collateral circulation, which helped us plan tailored treatment. Although very rare, we must consider the possibility of PAA in adults with unexplained hemoptysis.
  • 経皮経肝門脈右枝塞栓後にcoronavirus disease 2019に罹患した盲腸癌肝転移の治癒的切除例
    藤好 直; 柿坂 達彦; 松澤 文彦; 下國 達志; 木井 修平; 蔵谷 勇樹; 西川 眞; 森田 亮; 中西 勝也; 高木 智史; 高橋 昌宏
    日本消化器外科学会雑誌, 55, 6, 389, 398, (一社)日本消化器外科学会, Jun. 2022
    Japanese
  • 画像データの実体化による画像診断・IVR技術の高精度化を目指した研究
    阿保 大介; 曽山 武士; 森田 亮
    北海道放射線医学雑誌, 2, 26, 28, (NPO)メディカルイメージラボ, Mar. 2022
    Japanese
  • Curative Liver Resection in a Case of Cecum Cancer Liver Metastasis after Coronavirus Disease-19 Following Percutaneous Transhepatic Portal Vein Embolization
    藤好直; 柿坂達彦; 松澤文彦; 下國達志; 木井修平; 蔵谷勇樹; 西川眞; 森田亮; 中西勝也; 高木智史; 高橋昌宏
    日本消化器外科学会雑誌(Web), 55, 6, 2022
  • Single-Session Intranodal Glue Embolization for Postsurgical Refractory Groin Lymphorrhea: A Case Report
    Sho Sosogi; Daisuke Abo; Ryo Morita; Takeshi Soyama; Bunya Takahashi; Yuki Yoshino; Koji Yamasaki; Noriyuki Miyamoto; Kohsuke Kudo
    Interventional Radiology, The Japanese Society of Interventional Radiology, 2022
    Scientific journal
  • Successful transvenous embbolization for type II uterine arteriovenous malformation: A case report.
    Ryo Morita; Daisuke Abo; Naoya Kinota; Takeshi Soyama; Bunya Takahashi; Yuki Yoshino; Satonori Tsuneta; Kohsuke Kudo
    Radiology case reports, 16, 8, 2007, 2011, Aug. 2021, [International Magazine]
    English, A 40-year-old female (gravida 3 para 1) presented with menstrual, urinary, and anal pain. Computed tomography revealed type II acquired uterine arteriovenous malformation, a common dilated venous sac with bilateral uterine arteries, and multiple branches of iliac arteries draining to the bilateral ovarian veins. Venous sac transvenous embolization via the left ovarian vein of dominant outflow was planned, since complete arteriovenous malformation occlusion was difficult with super-selective transarterial embolization of multiple feeders. Therefore, transarterial embolization of the minor feeder was performed before completing transvenous embolization using coils and 50% glue under left iliac artery flow control. Immediately thereafter, angiography confirmed the complete disappearance of the uterine arteriovenous malformation, and all pain symptoms remitted. In conclusion, transvenous embolization combined with adjunctive transarterial embolization can be an effective and radical treatment for type II uterine arteriovenous malformations.
  • Treatment outcomes of stereotactic body radiation therapy using a real-time tumor-tracking radiotherapy system for hepatocellular carcinomas.
    Yusuke Uchinami; Norio Katoh; Daisuke Abo; Hiroshi Taguchi; Koichi Yasuda; Kentaro Nishioka; Takeshi Soyama; Ryo Morita; Naoki Miyamoto; Ryusuke Suzuki; Takuya Sho; Masato Nakai; Koji Ogawa; Tatsuhiko Kakisaka; Tatsuya Orimo; Toshiya Kamiyama; Shinichi Shimizu; Hidefumi Aoyama
    Hepatology research : the official journal of the Japan Society of Hepatology, 51, 8, 870, 879, 24 Apr. 2021, [International Magazine]
    English, Scientific journal, AIM: To report the outcomes of stereotactic body radiotherapy using a real-time tumor-tracking radiotherapy system for hepatocellular carcinoma patients. METHODS: From January 2005 to July 2018, 63 patients with 74 lesions with a maximum diameter ≤52 mm were treated by stereotactic body radiotherapy using a real-time tumor-tracking radiotherapy system. No patient with a Child-Pugh Score ≥9 was included, and 85.6% had a score of 5 or 6. Using the biological effective dose (BED) with an α/β ratio of 10 (BED10 ), the median dose in BED10 at the reference point was 76.8 Gy (range 60-122.5 Gy). Overall survival (OS) and local control rates were assessed using the Kaplan-Meier method. RESULTS: With a median follow-up period of 24.6 months (range 0.9-118.4 months), the 1-year and 2-year OS rates were 86.8% (95% confidence interval [95% CI] 75.8-93.3) and 71.1% (57.8-81.6), respectively. The 2-year OS was 89.6% in patients with the baseline modified albumin-bilirubin (mALBI) grade =1, and 61.7% in patients with grade ≥2a. In the multivariate analysis, the mALBI grade (=1 vs. ≥2a) was a significant factor for OS (p = 0.028, 95% CI 1.11-6.18). The 1-year and 2-year local control rates were 100% (100-100%) and 92.0% (77.5-97.5%). The local control rates were significantly higher in the BED10 ≥100 Gy group than in the BED10 <100 Gy group (2-year 100% vs. 86.5%, p = 0.049) at the reference point. CONCLUSION: This retrospective study of stereotactic body radiotherapy using real-time tumor-tracking radiotherapy for hepatocellular carcinoma showed favorable outcomes with lower incidence of toxicities, especially in patients treated with BED10 ≥100 Gy to the reference point.
  • Percutaneous insertion of hepatic fiducial true-spherical markers for real-time adaptive radiotherapy.
    Ryo Morita; Daisuke Abo; Yusuke Sakuhara; Takeshi Soyama; Norio Katoh; Naoki Miyamoto; Yuusuke Uchinami; Shinichi Shimizu; Hiroki Shirato; Kohsuke Kudo
    Minimally invasive therapy & allied technologies : MITAT : official journal of the Society for Minimally Invasive Therapy, 29, 6, 334, 343, Dec. 2020, [International Magazine]
    English, Scientific journal, Purpose: This study evaluated the success rate and complications of percutaneous implantation of hepatic fiducial true-spherical gold markers for real-time adaptive radiotherapy (RAR), which constitutes real-time image-guided radiotherapy with gating.Material and methods: We retrospectively evaluated 100 patients who underwent 116 percutaneous intrahepatic implantations of 2-mm-diameter, spherical, gold fiducial markers before RAR from 1999 to 2016, with Seldinger's method. We defined technical success as marker placement at the intended liver parenchyma, without mispositioning, and clinical success as successful tracking of the gold marker and completion of planned RAR. Complications related to marker placement were assessed.Results: The technical success rate for true-spherical gold marker implantation was 92.2% (107/116). Nine of 116 markers migrated (intra-procedurally in seven patients, delayed in two patients). Migration out of the liver (n = 4) or intrahepatic vessels (n = 5) occurred without complications; these markers were not retrieved. The clinical success rate was 100.0% (115/115). Abdominal pain occurred in 16 patients, fever and hemorrhage in seven patients each, and pneumothorax and nausea in one patient each. No major complications were encountered.Conclusions: Percutaneous transhepatic implantation of true-spherical gold markers for RAR is feasible and can be conducted with a high success rate and low complication rate.
  • Visualization of Quantitative Flow Reduction with 4D-flow Magnetic Resonance Imaging in a Patient with Pelvic Arteriovenous Malformation After Transcatheter Arterial Embolization.
    Satonori Tsuneta; Daisuke Abo; Noriko Oyama-Manabe; Chihoko Miyazaki; Yuki Yoshino; Ryo Morita; Takeshi Soyama; Kohsuke Kudo
    Cardiovascular and interventional radiology, 43, 10, 1557, 1560, Oct. 2020, [International Magazine]
    English, Scientific journal
  • Spontaneous rupture of the pancreatic arcade artery caused by neurofibromatosis type 1 successfully treated using emergency transcatheter arterial embolization, partial intra-aortic balloon occlusion, and stent graft placement: a case report and review of the literature.
    Ryo Morita; Daisuke Abo; Takeshi Soyama; Yuki Yoshino; Toru Yoshikawa; Tasuku Kimura; Kohsuke Kudo
    CVIR endovascular, 3, 1, 37, 37, 26 Jul. 2020, [International Magazine]
    English, Scientific journal, BACKGROUND: Vascular abnormalities in neurofibromatosis type 1 (NF1) are rare, but are the second leading cause of death in persons with NF1. In NF1 vasculopathy (NF-V), fatal bleeding due to a spontaneous arterial rupture sometimes occurs. Ruptured extracranial arteries in patients with NF1 often involve thoracic vessels, such as the intercostal and subclavian arteries; very few reports exist regarding the abdominal region. Herein, we present the first case of intraperitoneal bleeding due to spontaneous pancreatic arcade artery (PAA) rupture associated with NF1, successfully treated by transcatheter arterial embolization (TAE) combined with stent-graft placement and partial intra-aortic balloon occlusion (IABO). CASE PRESENTATION: A 40-year-old woman complained of back and abdominal pain. Upon admission, her blood pressure was 85/41 mmHg and heart rate was 129 beats/min. Computed tomography (CT) showed large intraperitoneal bleeding due to PAA rupture. After CT scanning, her systolic blood pressure decreased to 50 mmHg. Therefore, we performed emergency TAE with partial IABO. She was treated by TAE of the anterior superior pancreaticoduodenal artery, anterior inferior pancreaticoduodenal artery, and inferior pancreaticoduodenal artery. However, even after TAE, minor extravasation around the superior mesenteric artery continued, and her vital signs remained unstable. Stent-graft placement was selected to stop the haemorrhage, preserving normal blood flow of the superior mesenteric artery trunk. Excellent patency of the stent graft was confirmed on follow-up CT, and she was discharged on postoperative day 56. CONCLUSION: PAA rupture associated with NF1 can be successfully treated by TAE combined with partial intra-aortic balloon occlusion, and stent-graft placement.
  • Percutaneous Drainage for Post-operative Complications after Hepato-Biliary Pancreatic Surgery
    Morita Ryo; Abo Daisuke; Soyama Takeshi; Takahashi Bunya; Yoshino Yuki; Yamasaki Koji; Kudo Kohsuke
    The Official Journal of the Japanese Society of Interventional Radiology, 35, 2, 113, 126, The Japanese Society of Interventional Radiology, 2020
    Japanese, Post-operative complications such as abdominal fluid collection, abscess, bile leakage (BL) and pancreatic fistula (PF) can occur after hepato-biliary pancreatic surgery. Effective drainage is essential for these post-operative complications. Here, we describe non-vascular IR techniques for post-operative complications after hepato-biliary pancreatic surgery, showing our cases.
  • Initial Clinical Outcomes of Real-Time-Image Gated Spot-Scanning Proton Beam Therapy for Hepatocellular Carcinomas
    N. Katoh; Y. Uchinami; D. Abo; S. Takao; T. Inoue; H. Taguchi; R. Morita; T. Soyama; T. Hashimoto; R. Onimaru; A. Prayongrat; M. Tamura; T. Matsuura; S. Shimizu; H. Shirato
    International Journal of Radiation Oncology*Biology*Physics, 105, 1, E222, E223, Elsevier BV, Sep. 2019
    Scientific journal
  • Quantitative evaluation of image recognition performance of fiducial markers in real-time tumor-tracking radiation therapy.
    Naoki Miyamoto; Kenichiro Maeda; Daisuke Abo; Ryo Morita; Seishin Takao; Taeko Matsuura; Norio Katoh; Kikuo Umegaki; Shinichi Shimizu; Hiroki Shirato
    Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB), 65, 33, 39, Sep. 2019, [International Magazine]
    English, Scientific journal, PURPOSE: To quantitatively evaluate and compare the image recognition performance of multiple fiducial markers available in real-time tumor-tracking radiation therapy (RTRT). METHODS: Clinically available markers including sphere shape, coil shape, cylinder shape, line shape, and ball shape (folded line shape) were evaluated in liver and lung models of RTRT. Maximum thickness of the polymethyl metacrylate (PMMA) phantom that could automatically recognize the marker was determined by template-pattern matching. Image registration accuracy of the fiducial marker was determined using liver RTRT model. Lung RTRT was mimicked with an anthropomorphic chest phantom and a one-dimensional motion stage in order to simulate marker motion in heterogeneous fluoroscopic images. The success or failure of marker tracking and image registration accuracy for the lung model were evaluated in the same manner as that for the liver model. RESULTS: All fiducial markers except for line shape and coil shape of thinner diameter were recognized by the PMMA phantom, which is assumed to have the typical thickness of an abdomen, with two-dimensional image registration accuracy of <2 pixels. Three-dimensional calculation error with the use of real-time stereoscopic fluoroscopy in RTRT was thought to be within 1 mm. In the evaluation using the lung model, the fiducial markers were recognized stably with sufficient accuracy for clinical application. The same was true for the evaluation using the liver model. CONCLUSIONS: The image recognition performance of fiducial markers was quantified and compared. The results presented here may be useful for the selection of fiducial markers.
  • Spontaneous Recovery of Multiple Hepatic Artery Aneurysms with Segmental Arterial Mediolysis
    Ryo Morita; Daisuke Abo; Takeshi Soyama; Yusuke Sakuhara; Masayoshi Kajiyama; Kohsuke Kudo
    Interventional Radiology, 3, 2, 88, 92, The Japanese Society of Interventional Radiology, 30 Jun. 2018
    English, Scientific journal, A 50-year-old woman with liver dysfunction complained of back pain. Computed tomography showed multiple fusiform aneurysms in the right and left hepatic arteries. As she was hemodynamically stable, antihypertensive therapy was selected to reduce the risk of rupture. During hospitalization, spontaneous and progressive thrombosis formation of multiple hepatic artery aneurysms was observed. She was diagnosed with segmental arterial mediolysis based on her clinical course and imaging findings, and she was discharged after 48 days. One year following discharge, computed tomography showed complete recovery and patent, normal hepatic arterial branches. Segmental arterial mediolysis should be considered as a condition that can cause multiple hepatic artery aneurysms, which can be treated successfully with antihypertensive therapy and careful follow-up observation with imaging when the patient's hemodynamic state is stable.
  • Preoperative Embolization in Preparation for Distal Pancreatectomy with En Bloc Celiac Axis Resection
    Abo Daisuke; Hirano Satoshi; Nakamura Toru; Soyama Takeshi; Morita Ryo; Yoshino Yuki; Kimura Tasuku; Kanaya Motoma; Koizumi Fuki; Kudo Kohsuke
    The Official Journal of the Japanese Society of Interventional Radiology, 33, 3, 229, 235, The Japanese Society of Interventional Radiology, 2018
    Japanese, Distal pancreatectomy with en bloc celiac axis resection (DP-CAR) was designed to provide microscopically negative margins of the celiac artery, nerve plexus, and retroperitoneal tissue for patients with locally advanced pancreatic body cancer. We have been routinely performing the preoperative embolization of CHA for those patients scheduled for DP-CAR since August 1998, to limit the post-surgical ischemic complications of the liver, gall bladder and stomach, by maintaining the blood supply through development of collateral pathways via the superior mesenteric artery and pancreatic arcade. When performing preoperative CHA embolization, it is important to preserve the proper hepatic artery and gastroduodenal artery in order to develop the collateral pathways. It is also preferable to preserve a more than 5-mm length of the distal CHA for easier ligation at surgery. We employed several conventional embolization techniques. However, migration of embolic material from CHA occurred in several patients. From these experiences, we developed an embolization technique using two simultaneous microcatheters and interlocking detachable coils (IDCs). We call this a "dual microcatheter-dual IDC (DMDI) technique". The DMDI technique provided an excellent high success rate than conventional technique. Recently, embolization technique using amplatzer vascular plug4 (AVP4) has become an good alternative to DMDI technique due to its excellent ease of positioning of AVP4.
  • The Steerable Microcatheter: A New Device for Selective Catheterisation.
    Takeshi Soyama; Daisuke Yoshida; Yusuke Sakuhara; Ryo Morita; Daisuke Abo; Kohsuke Kudo
    Cardiovascular and interventional radiology, 40, 6, 947, 952, Jun. 2017, [International Magazine]
    English, Scientific journal
  • Spontaneous hemoperitoneum due to rupture of the paraumbilical vein successfully treated with balloon-occluded retrograde transvenous obliteration.
    Sho Kitagawa; Takahiro Sato; Katsu Yamazaki; Takumi Ohmura; Yoshiyasu Karino; Jouji Toyota; Takashi Hasegawa; Wataru Sakai; Ryo Morita
    Clinical journal of gastroenterology, 6, 1, 75, 9, Feb. 2013, [Domestic magazines]
    English, Scientific journal, Spontaneous hemoperitoneum is an uncommon condition, which may be critical even if treated appropriately. The paraumbilical vein is a portosystemic collateral vein that develops in patients with portal hypertension, and is rarely found to be a source of bleeding. Here we present a case report of spontaneous hemoperitoneum due to rupture of the paraumbilical vein successfully treated with balloon-occluded retrograde transvenous obliteration (B-RTO). A 69-year-old man with cirrhosis due to nonalcoholic steatohepatitis was admitted to our hospital with abdominal distention and pain. Computed tomography revealed hemoperitoneum with a dilated paraumbilical vein, and rupture of the paraumbilical vein was diagnosed to be the cause of anemia. B-RTO was performed via the left femoral vein with upstream embolization using microcoils, and thrombosis of the paraumbilical vein was confirmed after B-RTO. The patient was discharged without complications 20 days after B-RTO and he experienced no further episodes of bleeding during the subsequent 6-month period.
  • Hyperintense putaminal rim at 1.5 T: prevalence in normal subjects and distinguishing features from multiple system atrophy.
    Khin K Tha; Satoshi Terae; Akiko Tsukahara; Hiroyuki Soma; Ryo Morita; Ichiro Yabe; Yoichi M Ito; Hidenao Sasaki; Hiroki Shirato
    BMC neurology, 12, 39, 39, 18 Jun. 2012, [International Magazine]
    English, Scientific journal
■ Other Activities and Achievements
■ Lectures, oral presentations, etc.
  • ここまでできる!術後感染性合併症に対するIVR 術後合併症に対する経皮的ドレナージにおける既存ドレーン経路・瘻孔利用
    阿保 大介; 曽山 武士; 森田 亮; 高橋 文也; 木野田 直也; 安井 太一; 工藤 與亮
    日本外科感染症学会雑誌, Nov. 2021, (一社)日本外科感染症学会, Japanese
    Nov. 2021 - Nov. 2021
  • 腫瘍性骨軟化症に対してブロスマブを使用した3例
    宮崎 あすか; 亀田 啓; 大江 悠希; 泉原 里美; 重沢 郁美; 野本 博司; 曹 圭龍; 中村 昭伸; 坂本 圭太; 森田 亮; 曽山 武士; 阿保 大介; 工藤 與亮; 三好 秀明; 渥美 達也
    日本内分泌学会雑誌, Oct. 2021, (一社)日本内分泌学会, Japanese
    Oct. 2021 - Oct. 2021
  • 肝胆膵術後膵液瘻のドレナージ治療の基本と工夫
    阿保 大介; 曽山 武士; 森田 亮; 高橋 文也; 木野田 直也; 工藤 與亮
    日本医学放射線学会秋季臨床大会抄録集, Aug. 2021, (公社)日本医学放射線学会, Japanese
    Aug. 2021 - Aug. 2021
  • 開放創部の術後リンパ漏に対しリンパ管塞栓術が有効であった一例(Glue in open wound directly confirmed with intranodal glue embolization for groin lymphorrhea)
    曽々木 昇; 森田 亮; 山崎 康之; 阿保 大介; 曽山 武士; 高橋 文也; 吉野 裕紀; 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌, Apr. 2021, (一社)日本インターベンショナルラジオロジー学会, English
    Apr. 2021 - Apr. 2021
  • 胃静脈瘤に対する経皮経門脈的塞栓術の経験
    高橋 文也; 阿保 大介; 曽山 武士; 森田 亮; 吉野 裕紀; 山崎 康之; 曽々木 昇; 宮本 憲幸; 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌, Apr. 2021, (一社)日本インターベンショナルラジオロジー学会, Japanese
    Apr. 2021 - Apr. 2021
  • 肝エキノコックス症による門脈狭窄に対しバルーン拡張型カバードステントを留置した1例
    山崎 康之; 阿保 大介; 森田 亮; 吉野 裕紀; 高橋 文也; 曽山 武士; 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌, Apr. 2021, (一社)日本インターベンショナルラジオロジー学会, Japanese
    Apr. 2021 - Apr. 2021
  • 肺動静脈奇形に対する4D flow MRIによる血流評価の実行可能性に関する検討
    阿保 大介; 常田 慧徳; 曽山 武士; 森田 亮; 吉野 裕紀; 高橋 文也; 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌, Apr. 2021, (一社)日本インターベンショナルラジオロジー学会, Japanese
    Apr. 2021 - Apr. 2021
  • Type 3大動脈弓模型の3分枝へのカテーテライゼーション(Catheterization into branches of simplified type 3 arch models)
    曽山 武士; 今井 哲秋; 吉野 裕紀; 高橋 文也; 森田 亮; 阿保 大介; 吉田 大介; 東海林 菊太郎; 長内 俊也; 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌, Apr. 2021, (一社)日本インターベンショナルラジオロジー学会, English
    Apr. 2021 - Apr. 2021
  • 尿管動脈瘻に対して血管内治療を行なった1例
    杉戸 悠紀; 山田 修平; 千葉 博基; 堀田 記世彦; 木野田 直也; 森田 亮; 阿保 大介; 篠原 信雄
    泌尿器外科, Mar. 2021, 医学図書出版(株), Japanese
    Mar. 2021 - Mar. 2021
  • 胆汁漏膵液瘻を起こしても必ず患者を救え!ドレーン管理とIVRの進歩 肝胆膵術後膵液瘻に対するnon-vascular IVR
    阿保 大介; 曽山 武士; 森田 亮; 高橋 文也; 吉野 裕紀; 工藤 與亮
    日本外科感染症学会雑誌, Oct. 2020, (一社)日本外科感染症学会, Japanese
    Oct. 2020 - Oct. 2020
  • 肺動静脈奇形に対し卵円孔経由で経静脈的塞栓術を施行した1例
    阿保 大介; 曽山 武士; 永井 利幸; 森田 亮; 吉野 裕紀; 木野田 直也; 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌, Aug. 2020, (一社)日本インターベンショナルラジオロジー学会, Japanese
    Aug. 2020 - Aug. 2020
  • 外腸骨動脈破裂を来たした子宮頸癌治療後難治性腸管穿孔の1例
    木野田 直也; 森田 亮; 阿保 大介; 曽山 武士; 吉野 裕紀; 工藤 與亮; 野崎 綾子; 加藤 達矢; 渡利 英道
    日本インターベンショナルラジオロジー学会雑誌, Aug. 2020, (一社)日本インターベンショナルラジオロジー学会, Japanese
    Aug. 2020 - Aug. 2020
  • 子宮動脈-卵巣動脈吻合枝領域からの出血をNBCAで塞栓した1例
    渡辺 祈一; 森田 亮; 阿保 大介; 曽山 武士; 吉野 裕紀; 木野田 直也; 加藤 扶美; 桜井 康雄; 児玉 芳尚; 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌, Aug. 2020, (一社)日本インターベンショナルラジオロジー学会, Japanese
    Aug. 2020 - Aug. 2020
  • 子宮動静脈奇形に対し動脈塞栓術併用経静脈的塞栓術を施行した1例
    森田 亮; 阿保 大介; 木野田 直也; 曽山 武士; 吉野 裕紀; 常田 慧徳; 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌, Aug. 2020, (一社)日本インターベンショナルラジオロジー学会, Japanese
    Aug. 2020 - Aug. 2020
  • Up-to-7 inのHCC患者において超選択的TACEは選択的TACEに対しsurvival benefitを有するか?
    吉野 裕紀; 阿保 大介; 森田 亮; 曽山 武士; 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌, Aug. 2020, (一社)日本インターベンショナルラジオロジー学会, Japanese
    Aug. 2020 - Aug. 2020
  • 巨大骨盤AVMに対する塞栓術の治療効果を4D-flow MRIにより定量的に評価できた一例(Quantitative evaluation of a giant pelvic arteriovenous malformation by 4D-flow MRI: a case report)
    阿保 大介; 常田 慧徳; 真鍋 徳子; 曽山 武士; 森田 亮; 吉野 裕紀; 木野田 直也; 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌, Aug. 2020, (一社)日本インターベンショナルラジオロジー学会, English
    Aug. 2020 - Aug. 2020
  • コイル塞栓術における先端可動型マイクロカテーテルの先端ロック機構の有用性の基礎的検討
    阿保 大介; 曽山 武士; 森田 亮; 上石 崇史; 金谷 本真; 高柳 歩; 山崎 康之; 吉野 裕紀; 木村 輔; 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌, May 2019, (一社)日本インターベンショナルラジオロジー学会, Japanese
    May 2019 - May 2019
  • 膵アーケード破裂に対して動脈塞栓術及びステントグラフト留置により救命しえた神経線維腫症1型の1例
    森田 亮; 阿保 大介; 木村 輔; 上石 崇史; 曽山 武士; 吉野 裕紀; 工藤 興亮
    日本インターベンショナルラジオロジー学会雑誌, May 2019, (一社)日本インターベンショナルラジオロジー学会, Japanese
    May 2019 - May 2019
  • 左下横隔動脈経由で還流されていた脾動脈に対しPSEを施行した1例
    木村 輔; 阿保 大介; 吉野 裕紀; 森田 亮; 曽山 武士; 工藤 與亮
    日本インターベンショナルラジオロジー学会雑誌, Apr. 2019, (一社)日本インターベンショナルラジオロジー学会, Japanese
    Apr. 2019 - Apr. 2019
  • 救命率を向上させる外科とIVRとのコラボレーション 救命率を向上させる外科とIVRとのコラボレーション症例
    森田 亮; 曽山 武士; 阿保 大介; 工藤 與亮
    Japanese Journal of Acute Care Surgery, Sep. 2017, 日本Acute Care Surgery学会, Japanese
    Sep. 2017 - Sep. 2017
  • 肝腫瘍に対する動態追跡照射のための経皮的マーカ留置(Percutaneous hepatic fiducial marker implantation for Real-time Tumor-tracking Radiotherapy(RTRT))
    森田 亮; 作原 祐介; 曽山 武士; 阿保 大介; 加藤 徳雄; 工藤 與亮; 白土 博樹
    IVR: Interventional Radiology, Apr. 2017, (一社)日本インターベンショナルラジオロジー学会, English
    Apr. 2017 - Apr. 2017
■ Syllabus
  • 医学総論, 2024年, 博士後期課程, 医学研究科
  • 基本医学総論, 2024年, 修士課程, 医学院
  • 基本医学総論, 2024年, 修士課程, 医学院
  • 基本医学総論, 2024年, 修士課程, 医学院
  • 医学総論, 2024年, 博士後期課程, 医学院
  • 医学総論, 2024年, 博士後期課程, 医学院
  • 医学総論, 2024年, 博士後期課程, 医学院
  • 画像診断学, 2024年, 学士課程, 医学部
■ Research Themes
  • 超高精細血管モデルによる医学的手技トレーニングシステムを用いた非侵襲的技術伝承
    科学研究費助成事業
    01 Apr. 2025 - 31 Mar. 2028
    森田 亮
    日本学術振興会, 若手研究, 北海道大学, 25K17070
  • カテーテル選択支援AIを用いたVascular IVRの開発
    科学研究費助成事業 若手研究
    01 Apr. 2022 - 31 Mar. 2025
    森田 亮
    日本学術振興会, 若手研究, 北海道大学, 22K15875
  • 4D Flow-MRIによる門脈塞栓術後の残肝肥大予測法確立と先制IVRの開発
    科学研究費助成事業 基盤研究(C)
    01 Apr. 2021 - 31 Mar. 2024
    阿保 大介; 曽山 武士; 森田 亮; 神山 俊哉
    研究開始の初年度は、本研究の実施のコアとなる、経皮的門脈塞栓術を含めた門脈系IVR（カテーテル治療/画像下治療）に対する4D Flow-MRIを用いた門脈系の血流評価に関する前向き観察研究の臨床研究のプロトコル作成とIRB申請を行った。
    門脈系の4D-Flow MRIの撮像方法は、まだ定まった方法が存在しないというのが現状である。加えて、これまでの既報では造影剤を併用して実施されている方法が一般的である。しかし、我々は、繰り返し実施する際の患者侵襲（静脈注射による疼痛、腎機能への負担、アレルギー発症リスク等）を無くし、より多くの患者に適応できる方法へ発展させたいという観点から、造影剤を使用せずに（非造影で）評価可能な4D-Flow MRI撮像方法の確立を目指している。
    研究初年度の今年度は、前述のように、非造影での4D-Flow MRI 撮像方法の確立と最適化を目指し、数名の健常人ボランティアを用いて血管描出と4D-flow MRIの画像を位置合わせの方法（主にパラメーター設定）を模索した。並行して門脈塞栓術を含めた門脈系IVR前後での4D-Flow MRI症例のリクルート・症例集積及び処置前後における撮像を行い、各症例で得られた知見をフィードバックし、それ以降の症例の撮像方法の改良を継続的に実施した。
    また4D-Flow MRIの撮像を行う症例については、門脈塞栓術時の血管造影法についても、4D-Flow MRIと比較・検討することを念頭にプロトコールの改良を実施した。
    日本学術振興会, 基盤研究(C), 北海道大学, 21K07637
  • Catheterization difficulties and optimal catheter design for angiography using deep learning.
    Grants-in-Aid for Scientific Research
    11 Sep. 2020 - 31 Mar. 2022
    Morita Ryo
    This study was conducted to develop artificial intelligence (AI) capable of determining the difficulty of catheter insertion into the target vessel for endovascular catheterization. AI analysis was performed based on a difficulty evaluation test for visibility using CT VR data from the celiac artery to the common hepatic artery performed by one specialist in 2020. The results showed that the overall accuracy was relatively good at 89.05% when cases were divided into difficult and non-difficult cases. In 2021, an AI analysis based on a visibility evaluation study by three IVR specialists was performed. The overall accuracy was more than 60% when discriminating between difficult and non-difficult catheter insertion cases and more than 80% when selecting non-difficult cases.
    Japan Society for the Promotion of Science, Grant-in-Aid for Research Activity Start-up, Hokkaido University, 20K22862
■ Industrial Property Rights