Ph.D., Hokkaido University

chemical engineering

separation operation

reaction engineering

adsorption process

foam separation

flocculation

biodiesel

fisheries' biomass

Life Science, Aquatic life science

Manufacturing Technology (Mechanical Engineering, Electrical and Electronic Engineering, Chemical Engineering), Biofunction and bioprocess engineering

Manufacturing Technology (Mechanical Engineering, Electrical and Electronic Engineering, Chemical Engineering), Transport phenomena and unit operations

Manufacturing Technology (Mechanical Engineering, Electrical and Electronic Engineering, Chemical Engineering), Chemical reaction and process system engineering

Bachelor's degree program, School of Fisheries Sciences

Master's degree program, Graduate School of Fisheries Sciences

Doctoral (PhD) degree program, Graduate School of Fisheries Sciences

Surface-modified waste scallop shell as a flocculant and an optical method for evaluating flocculation performance
Hideo Maruyama
Separations, 13, 116, 14 Apr. 2026, [Peer-reviewed], [Lead author, Corresponding author]
English, Scientific journal

Effect of carboxylate additives on CaCO3 particle size by precipitation method using scallop shell
Hideo Maruyama; Shiro Takahashi
Materials Plus, 3, 2, 154, 168, 25 Jul. 2024, [Peer-reviewed], [Lead author, Corresponding author]
English, Scientific journal

Preparation of adsorbent by mechanochemical reaction based waste seashell with sodium oxalate and its application of Pb ion adsorption
Hideo Maruyama
Surfaces, 7, 2, 208, 224, 30 Mar. 2024, [Peer-reviewed], [Invited], [Lead author, Corresponding author]
English, Scientific journal

Adsorption of lactose using anion exchange resin by adding boric acid from milk whey
Hideo Maruyama; Hideshi Seki
Separations, 10, 10, 530, Oct. 2023, [Peer-reviewed], [Lead author, Corresponding author]
English, Scientific journal

Settling Velocity and Filtration Characteristics of Kaolin Floc Formed by Aluminum-Gelatin Composite Flocculant
Rino Tsukimura; Hideshi Seki; Hideo Maruyama
Bulletin of Fisheries Sciences, Hokkaido University, 73, 2, 57, 63, Sep. 2023, [Last author]
Japanese

Flocculation of Kaolin Suspension by Aluminum-Gelatin Composite Flocculant
Rino Tsukimura; Hideshi Seki; Hideo Maruyama
Bulletin of Fisheries Sciences, Hokkaido University, 73, 2, 45, 55, Sep. 2023, [Last author]
Japanese, Research institution

Adsorption of fatty acid methyl ester derived from squid liver lipid onto silica gel adsorbent
Hideo Maruyama, Akito Furukawa, Hideshi Seki
Separations, 10, 4, 244, 06 Apr. 2023, [Peer-reviewed], [Lead author, Corresponding author]
English, Scientific journal

Enhancement of metal ion fractionation by adding alginate in batch foam separation
Hideo Maruyama, Hideshi Seki
Biochemical Engineering Journal, 192, 108843, 10 Feb. 2023, [Peer-reviewed], [Lead author, Corresponding author]
English, Scientific journal

Esterification of tripalmitin using calcined scallop shell as a heterogeneous basic catalyst
Hideo Maruyama; Hideshi Seki
Asia-Pacific Journal of Chemical Engineering, 18, 2, e2870, 19 Dec. 2022, [Peer-reviewed], [Lead author, Corresponding author]
English, Scientific journal

Modeling of separation of fatty acid methyl esters derived from fisheries waste by urea complexation method
Hideo MARUYAMA; Keito Fukuchi; Hideshi SEKI
Biochemical Engineering Journal, 188, 108689, 19 Oct. 2022, [Peer-reviewed], [Lead author, Corresponding author]
English, Scientific journal

Biosorption of Pb;Cd onto Polygonum sachalinense
Ryo Taguchi, Hideshi Seki, Hideo Maruyama
Colloids and Surfaces A: Physicochemical and Engineering Aspects, 650, 129210, 129210, Elsevier BV, 09 May 2022, [Peer-reviewed], [Last author, Corresponding author]
English, Scientific journal

Enhancement of separation rate and recovery efficiency of milk whey proteins by addition of calcium and magnesium ions in batch foam separation
Hideo Maruyama; Hideshi Seki
Process Safety and Environmental Protection, 162, 1102, 1106, Elsevier BV, May 2022, [Peer-reviewed], [Lead author, Corresponding author]
English, Scientific journal

Evaluation of flocculation performance of polysaccharide-protamine complex flocculant by flocculation model
Hideo Maruyama; Hideshi Seki
Biochemical Engineering Journal, 180, 108356, 108356, Elsevier BV, Mar. 2022, [Peer-reviewed], [Lead author, Corresponding author]
English, Scientific journal

Recovery of milk whey proteins by foam separation
Hideo Maruyama; Hideshi Seki
Process Safety and Environmental Protection, 159, 566, 574, Elsevier BV, Mar. 2022, [Peer-reviewed], [Lead author, Corresponding author]
English, Scientific journal

Adsorption modeling by two sites Langmuir type isotherm for adsorption of bisphenol-A and diethyl phthalate onto activated carbon in single and binary system
Hideo Maruyama; Hideshi Seki
Separation Science and Technology, 57, 10, 1535, 1542, Informa UK Limited, 2022, [Peer-reviewed], [Lead author, Corresponding author]
English, Scientific journal

Adsorption behavior of methyl palmitate onto silica particle surface
Hideo Maruyama; Hideshi Seki; Akito Furukawa
Colloid and Interface Science Communications, 44, 100468, 100468, Elsevier BV, Sep. 2021, [Peer-reviewed], [Lead author, Corresponding author]
English, Scientific journal

Effect of soy protein-based flocculant on flocculation and filtration of diatomite and kaolin suspensions
Hideo Maruyama; Hideshi Seki
Water Science and Technology, 82, 9, 1868, 1876, IWA Publishing, 01 Nov. 2020, [Peer-reviewed], [Lead author, Corresponding author]
English, Scientific journal,
The effect of ethylated soy protein-based bioflocculant (EtSP) as a filter aid reagent was investigated. The efficiency of EtSP as a filter aid was evaluated in terms of the specific cake resistance, α, and was compared with chitosan and polyaluminum chloride (PAC). Diatomite and kaolin were used as model particles. Total filtration resistance, R, decreased with increasing flocculant dosage (wt.%, flocculant/particle) and was almost constant in the range of 1 wt.% or more for both particles. The α value was significantly decreased from 1.01 × 1011 to 9.01 × 1010 m/kg for diatomite and from 5.11 × 1010 to 5.20 × 109 m/kg for kaolin by the addition of EtSP in the case of 1.0 wt.%. The α value for cakes formed by EtSP was much smaller than that formed by chitosan and PAC. In the case of diatomite, in the dose range of 0.5–1.0 wt.%, the α value for cakes formed by EtSP and chitosan was almost the same. However, at the excess dose of 2.0 wt.% over, the α value formed by chitosan abruptly increased. In the case of kaolin, in the dose range of 1.0–2.0 wt.%, the α values of chitosan and PAC were mostly the same, however, these values were larger by ca. nine times than that of EtSP.

Flocculation of quartz and kaolin by alginate-protamine complex
Hideo Maruyama; Hideshi Seki; Ako Igi
Biochemical Engineering Journal, 162, 107713, 107713, Elsevier BV, Oct. 2020, [Peer-reviewed], [Lead author, Corresponding author]
English, Scientific journal

Influence of methylated milk casein flocculant dosage on removal rate of oil droplet removal from o/w in flotation
Hideo Maruyama; Hideshi Seki
Biochemical Engineering Journal, 159, 107584, 107584, Elsevier BV, Jul. 2020, [Peer-reviewed], [Lead author, Corresponding author]
Scientific journal

競争吸着法によるコンブのヨウ素低減方法
伊木 亜子; 喜多 壮太; 丸山 英男; 関 秀司
化学工学論文集, 44, 4, 247, 252, Aug. 2018, [Peer-reviewed]
Japanese, Scientific journal

イカ内蔵のカドミウム除去に用いるキレート樹脂のカドミウム吸脱着特性
杉崎 篤; 喜多 壮太; 丸山 英男; 関 秀司
北海道大学水産学部研究彙報, 67, 1, 1, 5, 2017
Japanese, Research institution

Modeling of competitive adsorption process for removing cadmium from squid viscera
Hideshi Seki; Hideo Maruyama; Masao Kawabe
Nippon Suisan Gakkaishi (Japanese Edition), 81, 1, 90, 96, Nihon Suisan Gakkai, 2015, [Peer-reviewed]
Japanese, Scientific journal

Development of system for removing cadmium from squid viscera by competitive adsorption method
Hideshi Seki; Hideo Maruyama; Masao Kawabe; Akihito Nakade
Nippon Suisan Gakkaishi (Japanese Edition), 79, 4, 703, 710, Nihon Suisan Gakkai, 2013, [Peer-reviewed]
Japanese, Scientific journal

Flocculation of kaolin and kanto loam by methylated soy protein
Xin Liu; Hideshi Seki; Hideo Maruyama
SEPARATION AND PURIFICATION TECHNOLOGY, 93, 1, 7, Jun. 2012, [Peer-reviewed]
English, Scientific journal

Removal kinetic model of oil droplet from o/w emulsion by adding methylated milk casein in flotation
Hideo Maruyama; Hideshi Seki; Yuuki Satoh
WATER RESEARCH, 46, 9, 3094, 3100, Jun. 2012, [Peer-reviewed], [Lead author, Corresponding author]
English, Scientific journal

Biosorption of heavy metals onto nonliving Laminaria japonica
Jun Xiao; Miyamoto Chikanori; Ke-Feng Yu; Seki Hideshi; Maruyama Hideo; Pei-Min He
WATER SCIENCE AND TECHNOLOGY, 65, 8, 1514, 1520, 2012, [Peer-reviewed]
English, Scientific journal

Flocculation of diatomite by a soy protein-based bioflocculant
Hideshi Seki; Hideo Maruyama; Yasuhiro Shoji
BIOCHEMICAL ENGINEERING JOURNAL, 51, 1-2, 14, 18, Aug. 2010, [Peer-reviewed]
English, Scientific journal

Biosorption of Cd2+, Pb2+ onto Laminaria japonica
Xiao, J; Miyamoto, C; Yu, K; Seki, H; Maruyama, H; He, P
Environmental Chemistry, 29, 2, 226, 230, 2010, [Peer-reviewed]
Chinese, Scientific journal

Flotation of blue-green algae using methylated egg ovalbumin
Hideo Maruyama; Hideshi Seki; Akira Suzuki
CHEMICAL ENGINEERING JOURNAL, 155, 1-2, 49, 54, Dec. 2009, [Peer-reviewed], [Lead author, Corresponding author]
English, Scientific journal

Enhancement of oil droplet removal from o/w emulsion by adding methylated milk casein in flotation technique
Hideo Maruyama; Yuhsuke Tada; Hideshi Seki
ASIA-PACIFIC JOURNAL OF CHEMICAL ENGINEERING, 4, 2, 211, 217, Mar. 2009, [Peer-reviewed], [Lead author, Corresponding author]
English, Scientific journal

Flocculation of diatomite by ethyl-esterified hen egg albumin
Hideshi Seki; Eri Hirai; Yasuhiro Shoji; Hideo Maruyama
Kagaku Kogaku Ronbunshu, 35, 1, 66, 69, 2009, [Peer-reviewed], [Last author]
Japanese, Scientific journal

Adsorption behavior of bisphenol-A and diethyl phthalate onto bubble surface in nonfoaming adsorptive bubble
Hideo Maruyama; Hideshi Seki; Yasuhiro Matsukawa; Akira Suzuki; Norio Inoue
CHEMICAL ENGINEERING JOURNAL, 141, 1-3, 112, 118, Jul. 2008, [Peer-reviewed], [Lead author, Corresponding author]
English, Scientific journal

Batch foam separation of a soluble protein
Hideo Maruyama; Hideshi Seki; Akira Suzuki; Norio Inoue
WATER RESEARCH, 41, 3, 710, 718, Feb. 2007, [Peer-reviewed], [Lead author, Corresponding author]
English, Scientific journal

Removal of bisphenol A and diethyl phthalate from aqueous phases by ultrasonic atomization
Hideo Maruyama; Hideshi Seki; Yasuhiro Matsukawa; Akira Suzuki; Norio Inoue
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 45, 18, 6383, 6386, Aug. 2006, [Peer-reviewed], [Lead author, Corresponding author]
English, Scientific journal

Variation of saturated surface density of ovalbumin on bubble surface in continuous foam separation
H Maruyama; H Seki; A Suzuki; N Inoue
JOURNAL OF COLLOID AND INTERFACE SCIENCE, 299, 1, 416, 420, Jul. 2006, [Peer-reviewed], [Lead author, Corresponding author]
English, Scientific journal

Enrichment in axial direction of aqueous foam in continuous foam separation
Hideo Maruyama; Akira Suzuki; Hideshi Seki; Norio Inoue
BIOCHEMICAL ENGINEERING JOURNAL, 30, 3, 253, 259, Jun. 2006, [Peer-reviewed], [Lead author, Corresponding author]
English, Scientific journal

Application of microthermometry to measurement of microbial activity and inactivation process by inhibitor
H Maruyama; A Suzuki; H Seki; N Inoue
BIOCHEMICAL ENGINEERING JOURNAL, 29, 3, 278, 283, Apr. 2006, [Peer-reviewed], [Lead author, Corresponding author]
English, Scientific journal

Adsorption characteristics and optimal dosage of flocculants in the solid separation of suspensions
A Suzuki; H Maruyama; H Seki; Kashiki, I; N Inoue
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 45, 3, 1123, 1127, Feb. 2006, [Peer-reviewed], [Corresponding author]
English, Scientific journal

Enrichment of amino acids by ultrasonic atomization
A Suzuki; H Maruyama; H Seki; Y Matsukawa; N Inoue
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 45, 2, 830, 833, Jan. 2006, [Peer-reviewed], [Corresponding author]
English, Scientific journal

ポリアクリルアミドゲル担持膜によるタンパク質と酵素の濃縮
鈴木 翼; 吉田 珠江; 関 秀司; 丸山 英男
化学工学論文集, 32, 1, 66, 71, 2006, [Peer-reviewed], [Last author]
Japanese, Scientific journal

Removal of Cadmium from Squid Liver by Competitive Adsorption Method
SEKI Hideshi; OKADA Itaru; MARUYAMA Hideo; KAWABE Masao; NAKADE Akihito
Aquaculture Science, 54, 4, 449, 453, Japanese Society for Aquaculture Science, 2006, [Peer-reviewed]
Japanese, Scientific journal, A new method (competitive adsorption method) for the removal of Cd from squid liver was proposed. In this method, the same weight of squid liver and citric acid solution were mixed with a cation-chelating resin for 24 h under weak acidic condition. The Cd concentration of the mixture was lowered from 12 ppm to 0.1 ppm by the addition of 10 wt-% of cation-chelating resin relative to the wet-weight of squid liver at about pH 4. The Cd adsorption behaviors of squid liver and cation-chelating resin were well explained by a bidentate binding model. The adsorption process of Cd onto cation-chelating resin was the rate-limiting process of competitive adsorption method.

水苔由来ピートモスによる重金属イオンのバイオソープション
関 秀司; 于 克鋒; 丸山 英男; 鈴木 翼
化学工学論文集, 35, 5, 449, 413, 2006, [Peer-reviewed]
Japanese, Scientific journal

Biosorption of chromium(VI) and arsenic(V) onto methylated yeast biomass
H Seki; A Suzuki; H Maruyama
JOURNAL OF COLLOID AND INTERFACE SCIENCE, 281, 2, 261, 266, Jan. 2005, [Peer-reviewed], [Last author]
English, Scientific journal

A Fundamental Study of Continuous Foam Separation of Uneaten Fish Feed with Methylated Egg Albumin
SEKI Hideshi; SUZUKI Akira; KUSHIBIKI Rie; MARUYAMA Hideo
Aquaculture Science, 53, 1, 41, 46, Japanese Society for Aquaculture Science, 2005, [Peer-reviewed], [Last author]
Japanese, Scientific journal, A fundamental study of the continuous foam separation of uneaten fish feed with a new biodegradable surfactant, methylated egg albumin (MeOA), was carried out. Pulverized fish feed particles with a mean diameter of 0.1 mm was used as a model system in this study. Continuous foam separation experiments were conducted at different mass flow rates of the feed particles, MeOA, and bubble surface production rates. A continuous foam separation model considering the adsorption of McOA and the feed particles to bubble surfaces was applied to explain the experimental results. The experimentally determined fractional removal of the feed particles agreed well with the values predicted by the model. The result showed that the fractional removal of feed particles can be predicted by the model with four basic operational parameters; mass flow rates of the feed particles and MeOA, bubble surface production rate, and volumetric flow rate of the water drained.

Adsorption of egg albumin onto methylated yeast biomass
H Seki; A Suzuki; H Maruyama
JOURNAL OF COLLOID AND INTERFACE SCIENCE, 270, 2, 304, 308, Feb. 2004, [Peer-reviewed], [Last author]
English, Scientific journal

Flocculation of diatomite by methylated milk casein in seawater
H Seki; A Suzuki; M Shinguh; H Maruyama
JOURNAL OF COLLOID AND INTERFACE SCIENCE, 270, 2, 359, 363, Feb. 2004, [Peer-reviewed], [Last author]
English, Scientific journal

Selective foam separation of binary protein solution by SIDS complexation method
A Suzuki; K Yasuhara; H Seki; H Maruyama
JOURNAL OF COLLOID AND INTERFACE SCIENCE, 253, 2, 402, 408, Sep. 2002, [Peer-reviewed], [Last author]
English, Scientific journal

Influence of liquid properties and operating variables on enrichment ratio in nonfoaming and foaming adsorptive bubble separation techniques
A Suzuki; H Maruyama
JOURNAL OF COLLOID AND INTERFACE SCIENCE, 238, 1, 54, 61, Jun. 2001, [Peer-reviewed], [Last author]
English, Scientific journal

Adsorption of water-soluble proteins onto bubbles in continuous foam separation
H Maruyama; A Suzuki; H Seki
JOURNAL OF COLLOID AND INTERFACE SCIENCE, 224, 1, 76, 83, Apr. 2000, [Peer-reviewed], [Lead author, Corresponding author]
English, Scientific journal

Adsorption behavior of organic substances onto bubble surface in nonfoaming bubble separation
A Suzuki; H Maruyama; H Seki
JOURNAL OF CHEMICAL ENGINEERING OF JAPAN, 29, 5, 794, 798, Oct. 1996, [Peer-reviewed]
English, Scientific journal

Application of Nonfoaming Bubble Separation to Enrichment of Dilute Dye Solution
A SUZUKI; H MARUYAMA; H SEKI; T HAYASHI
JOURNAL OF CHEMICAL ENGINEERING OF JAPAN, 28, 1, 115, 117, Feb. 1995, [Peer-reviewed]
English, Scientific journal

AN EQUILIBRIUM STUDY OF ADSORPTION OF DIVALENT METAL-IONS ONTO A METAL-OXIDE ADSORBENT
A SUZUKI; H SEKI; H MARUYAMA
JOURNAL OF CHEMICAL ENGINEERING OF JAPAN, 27, 4, 505, 511, Aug. 1994, [Peer-reviewed]
English, Scientific journal

ＰＶＡ固定化チタン酸によるウラン捕集に関する基礎的研究
関 秀司; 鈴木 翼; 丸山 英男
北大水産彙報, 44, 4, 147, 157, 1993, [Last author]
Japanese, Research institution

連続泡沫分離操作における泡沫層の脱水過程
丸山 英男; 鈴木 翼; 関 秀司
北大水産彙報, 44, 4, 238, 246, 1993, [Lead author, Corresponding author]
Japanese, Research institution

粒子トラップを取り付けた気泡塔による有機懸濁粒子の分離
丸山 英男; 関 秀司; 鈴木 翼; 酒井 信
北大水産彙報, 43, 4, 153, 161, 1992, [Lead author, Corresponding author]
Japanese, Research institution

アルギン酸固定化フミン酸膜への鉛イオン吸着に関する研究
関 秀司; 鈴木 翼; 丸山 英男
北大水産彙報, 42, 4, 46, 57, 1991, [Last author]
Japanese, Research institution

Recovery of milk whey proteins by foam separation
Maruyama, H; Seki, H
the 3rd International Symposium on Multiscale Multiphase Process Engineering, May 2017, English, Oral presentation

水溶性タンパク質の回分式泡沫分離操作における平衡残留濃度と除去速度
丸山 英男; 関 秀司; 鈴木 翼
化学工学会第24回秋季大会, Sep. 1991, Japanese, Oral presentation

水溶性タンパク質の泡沫分離における平衡残留濃度
丸山 英男; 鈴木 翼
化学工学会室蘭大会, C211, 1991, Japanese, Oral presentation

泡沫分離による水溶性タンパク質の除去
丸山 英男; 関 秀司; 鈴木 翼
化学工学会第23回秋季大会要旨集, Sep. 1990, Japanese, Oral presentation

含水チタン酸のウラン吸着性能に与えるゲル調製条件の影響について
丸山 英男; 関 秀司; 鈴木 翼
化学工学会第22回秋季大会要旨集, Sep. 1989, Japanese, Oral presentation

酵素機能化学, 2024年, 学士課程, 水産学部

環境と人間, 2024年, 学士課程, 全学教育

化学工学, 2024年, 学士課程, 水産学部

物理化学, 2024年, 学士課程, 水産学部

分析化学実験, 2024年, 学士課程, 水産学部

Course introduction of Physical Chemistry lecture (undergraduate specialization)
Hideo Maruyama, 17 Feb. 2021, [Educational materials]

Course introduction of Laboratory work of analytical chemistry (undergraduate specialization)
Hideo Maruayma, 17 Feb. 2021, [Educational materials]

Effective utilization and application for separation operation of marine biomass: Flocculation ability of alginate-protamine complex flocculant (English version)
Hideo Maruyama, 26 Jan. 2021, [Educational materials]

Effective utilization and application for separation operation of marine biomass: Flocculation ability of alginate-protamine complex flocculant
Hideo Maruyama, 26 Jan. 2021, [Educational materials]

マイクロサーモメトリーによるオンライン生菌数計測
科学研究費補助金(奨励研究(A))
1997 - 1998
丸山 英男
2本のビード型サーミスタ(B定数4,132K,100kΩ(25℃))を使用した差動方式による生菌数測定を行った.昨年度の結果よりこの方式によって回分式で約0.005℃の変化まで測定可能であった.昨年度に引き続きモデル微生物として大腸菌(Echerichia coli DH1),乳酸菌(Leuconostoc mesenteroides IFO3832)および酵母(Saccharomyces cerevisiae IFO2043)の3種類を使用した.連続式測定への応用のために,500mL三角フラスコ内で培養した菌体培養液を自作の測定用カラムと流路を取り付けた自作の容器に入れて液定量ポンプでその培養液を系内で循環させた.カラム容量は約10mLで入り口部とカラム内の出口付近にサーミスタを取り付け,カラムほぼ中央に基質注入口を取り付けたものを用いた.基質としては20g/Lグルコース溶液1mLを加えた.実験は全て30℃恒温水槽内で測定を行った.液循環体積速度を0.05〜0.5mL毎秒の範囲で変化させることによって,測定カラム内の平均液滞留時間を200〜20秒に変化させて実験を行った.この実験範囲では乳酸菌の発熱による温度変化は菌数を変化させてもほとんど得ることが出来なかった.これは基本的に乳酸菌の発熱量が酵母などと比較して非常に低いことが理由である.大腸菌を用いて滞留時間200秒で測定した場合,回分式で観測されたパルス型の温度変化はその時間および応答ともに20g-drycell/L以下の範囲で非常に小さく観測されたがばらつきが非常に大きく生菌数との明瞭な比例関係は得られなかった.同様に酵母を用いて滞留時間200秒で測定した場合,菌体濃度20〜40g-drycell/Lでパルス上の温度変化が観測されたが,感度の点では回分式よりも非常に劣った.今回行った実験範囲では菌体濃度を回分式の時よりも高濃度にしなければならなかった.
文部科学省, 奨励研究(A), 北海道大学, Principal investigator, Competitive research funding, 09750863

泡沫分離操作による水産廃水からの水溶性タンパク質の濃縮回収
科学研究費補助金(奨励研究(A))
1994 - 1994
丸山 英男
水産加工工程において魚介類から溶出する水溶性タンパク質の中で代表的なタンパク質は主に魚肉中のアルブミン類と血液に含まれているヘモグロビン類であるので,モデルタンパク質として水溶性タンパク質として卵白アルブミン(以下,OAと略する)および牛血清ヘモグロビン(以下,HBと略する)を用いた。泡沫分離装置として標準型気泡塔を用い,気液流通式で,OAについてはpH3.5,4.6(等電点)および6.0,または,HBについてはpH6.0,6.8(等電点)および8.0において泡沫分離実験を行なった。水溶性タンパク質の気液界面吸着はラングミュア型の吸着平衡関係にしたがうとの仮定から導いた泡沫分離過程モデルによって実験データを整理したところ,OAのpH3.5および6.0,および,HBの上記のpH範囲において,過去の研究で明らかにしたOAの等電点であるpH4.6同様に本研究で提起したモデルによくしたがい,ラングミュア型の吸着平衡関係であることがわかった。また,本モデルから決定した吸着パラメタである気泡表面飽和吸着量は,OAおよびHBともに等電点で最大を示し,酸およびアルカリ側で減少していた。これは気泡表面に吸着したタンパク質は等電点で静電気的に中性となるために,隣接する分子間の静電気的反発力が小さくなっているか,タンパク質分子が他のpHと比較して小さくなっていることが原因と考えられる。気泡層内での濃縮を明らかとするために,気泡塔内生成単位気泡表面積当たりの泡沫層に同伴される塔内液流量は本研究で行なった操作条件において無次元数であるオ-ネゾルゲ数で誤差30%以内で相関することができ,塔内平衡液濃度,約2×10^<-4>g/cm^3以下の濃度範囲で濃縮率が急激に増加することがわかった。泡沫液流量の鉛直方向分布は泡沫高さの上昇と共に指数関数的に急激に減少しており,塔内で発生した気泡表面積は泡沫層内でも維持されるとの仮定から吸着パラメタ及び上述の相関式を用いて泡沫層内濃縮率予測式を導いた。この式により,塔内平衡液濃度,約1×10^<-4>g/cm^3以上の濃度範囲では泡沫層内でも気泡表面積はほとんど維持されていることがわかった。
文部科学省, 奨励研究(A), 北海道大学, Principal investigator, Competitive research funding, 06760184

Editorial board member for separation engineering section of “Separations”(MDPI), August, 2024-.
06 Aug. 2024
Supervision, Review, Peer review
Peer review etc
https://www.mdpi.com/journal/separations/editors?search=Hideo+Maruyama

Guest editor, Special issue: Separation process for sustainable utilization of bioresources, Separations, MDPI, May 2024-.
Others
Others

Guest editor, Special issue: Separation process through adsorption for sustainable utilization of bioresources, Separations, MDPI, February 2024.
Others
Others