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Takashima Hiroyuki

Faculty of Health Sciences　Health Sciences　Biomedical Science and EngineeringAssociate Professor

Researcher basic information

■ URL
researchmap URLホームページURL■ Various IDs
Researcher number
  • 90608738
J-Global ID■ Research Keywords and Fields
Research Keyword
  • ミトコンドリア
  • 骨格筋
  • MRI
  • 拡散
Research Field
  • Life Science, Radiological sciences
■ Educational Organization

Career

■ Career
Career
  • Mar. 2022 - Present
    Hokkaido University
  • Sep. 2023 - Dec. 2023
    スタンフォード大学
  • Sep. 2021 - Sep. 2022
    Stanford University, United States
  • Apr. 2013 - Feb. 2022
    Sapporo Medical University, School of Medicine, 研究員

Research activity information

■ Awards
  • May 2021, Society for MR Radiographers & Technologists, Third Place Research Focus Electronic Poster Award
  • Oct. 2018, 日本運動器疼痛学会, 第11回日本運動器疼痛学会 学会奨励賞 優秀演題賞
  • May 2018, Society for MR Radiographers & Technologists (SMRT), John A. Koveleski (JAK) Award
  • Nov. 2016, 日本疼痛学会, 優秀論文賞
  • Sep. 2014, 日本磁気共鳴医学会, ISMRM Travel Award
  • Jul. 2014, 北海道整形災害外科学会, 学術奨励賞
  • May 2014, 整形災害外科研究助成財団, 財団奨励賞
  • Apr. 2009, 日本放射線技術学会北海道部会, 学術奨励賞
  • Apr. 2007, 日本放射線技術学会北海道部会, young investigator award
■ Papers
  • In vivo growing leporine model of pulmonary artery banding induces inflammation and vascular remodeling via pathways conserved across species
    Danielle M. Mullis; James Y. Lee; Masafumi Shibata; Veronica Toro Arana; Sumanth Kidambi; Amit Sharir; Perry S. Choi; Gentaro Ikeda; Riya Nilkant; Hiroyuki Takashima; Tsuyoshi Ueyama; Jay A. Huber; Y. Joseph Woo; Michael Ma
    JTCVS OPEN, 29, Feb. 2026
    English, Scientific journal
  • Longitudinal Analysis of Male Fertility Using an Acr‐Luc Knock‐In Mouse Model: A Preclinical Platform for Reproductive Toxicity Testing
    Hisanori Fukunaga; Ryosuke Seino; Yusuke Matsuya; Hiroyuki Takashima; Masayori Ishikawa; Yasuhito Onodera; Hiroki Shirato; Haruhiko Miyata; Kevin M. Prise
    MedComm, Jan. 2026
    Scientific journal
  • Impact of Pain on Lumbar Spine Functional Assessment: Are Sufficient Flexion and Extension Achieved?
    Tomonori Morita; Arihiko Tsukamoto; Ryunosuke Fukushi; Akimitsu Oyama; Makoto Emori; Hiroyuki Takashima; Jukyo Matsumoto; Toshihiko Yamashita; Atsushi Teramoto
    World neurosurgery, 206, 124752, 124752, 19 Dec. 2025, [International Magazine]
    English, Scientific journal
  • Overuse-Induced Muscle Disorder: Establishing a Rat Model to Unravel the Role of Fibro-Adipogenic Progenitor Cells in Intramuscular Fibrosis.
    Hiroyori Fusagawa; Tatsuya Sato; Azuma Naito; Nao Tokuda; Nao Yamauchi; Akiyoshi Uezumi; Madoka Uezumi; Yuki Saito; Minami Fusagawa; Hiroyuki Takashima; Nobutoshi Ichise; Toshifumi Ogawa; Takuro Karaushi; Noritsugu Tohse; Brian Feeley; Xuhui Liu; Atsushi Teramoto; Takashi Yamada
    Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 43, 12, 2102, 2113, Dec. 2025, [International Magazine]
    English, Scientific journal
  • Reliability of functional imaging in assessing instability of lumbar degenerative spondylolisthesis.
    Tomonori Morita; Arihiko Tsukamoto; Ryunosuke Fukushi; Shutaro Fujimoto; Makoto Emori; Hiroyuki Takashima; Tomohiro Izawa; Toshihiko Yamashita; Atsushi Teramoto
    European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 05 Nov. 2025, [International Magazine]
    English, Scientific journal
  • Distinct Mechanisms of Mitochondria-rich extracellular vesicle Therapy in Acute vs. Chronic Ischemic Heart Failure: A Single-Cell Transcriptomic Study
    Gentaro Ikeda; Eileen Tzng; Mariko Koike-Ieki; Hiroyuki Takashima; Jiwen Li; Jennifer Lyons; Connor O'Brien; Phillip Yang
    CIRCULATION, 152, SUPPL_3, 04 Nov. 2025
    English
  • Rapid manufacturing of angiogenic cellular collagen patches for ischemic cardiomyopathy.
    Eric Pfrender; Sungwoo Kim; John A Farag; Shin Yajima; Yujiro Kawai; Koji Kawago; Umayr Syed; Gentaro Ikeda; Tsuyoshi Ueyama; Hiroyuki Takashima; Alex Dalal; Yuanjia Zhu; Kenzo Ichimura; Yu Liu; Seyedsina Moeinzadeh; Jayme Koltsov; Joseph C Wu; Y Joseph Woo; Phillip C Yang; Yunzhi P Yang; Yasuhiro Shudo
    Stem cells translational medicine, 14, 9, 11 Sep. 2025, [International Magazine]
    English, Scientific journal
  • Ultrasound-Guided Fascial Hydrorelease for Persistent Pain After Hamstring Injury.
    Kousuke Shiwaku; Hidenori Otsubo; Daiki Nishikawa; Rikiya Itagaki; Hiroyuki Takashima; Gakuto Nakao; Tomoaki Kamiya; Daisuke Suzuki; Makoto Emori; Carla Stecco; Atsushi Teramoto
    Journal of functional morphology and kinesiology, 10, 3, 15 Aug. 2025, [International Magazine]
    English, Scientific journal
  • Stromal cell-derived factor-encapsulated nanoparticles target ischemic myocardium and attenuate myocardial injury via proangiogenic effects.
    Shin Yajima; Seung Hyun Lee; Junkai Yang; Matthew D Vergel; Manoj K Manna; Sho Kusadokoro; Yuanjia Zhu; Stefan Elde; Danielle M Mullis; Akshay Venkatesh; Sidarth Ethiraj; Tsuyoshi Ueyama; Hiroyuki Takashima; Samuel E Oh; Chris Huynh; Hanjay Wang; Yasuhiro Shudo; Shigeru Miyagawa; Yoshiki Sawa; Jayakumar Rajadas; Y Joseph Woo
    Biomaterials, 318, 123167, 123167, Jul. 2025, [International Magazine]
    English, Scientific journal
  • Safe, simple, and valid position for obtaining flexion-extension radiographs to assess instability in patients with lumbar spondylolisthesis: one specific instruction can make a difference.
    Tomonori Morita; Mitsunori Yoshimoto; Makoto Emori; Noriyuki Iesato; Ryunosuke Fukushi; Hiroyuki Takashima; Toshihiko Yamashita; Atsushi Teramoto
    Journal of neurosurgery. Spine, 42, 2, 133, 139, 01 Feb. 2025, [International Magazine]
    English, Scientific journal
  • Impact of double-bolus tracking to individualize scan timing of the portal venous phase in preoperative computed tomography colonography angiography for right-sided colon cancer.
    Yoshiya Ohashi; Masaaki Miyo; Koichi Okuya; Emi Akizuki; Atsushi Hamabe; Ai Noda; Masayuki Ishii; Ryo Miura; Momoko Ichihara; Maho Toyota; Kohei Okamoto; Shun Hayasaka; Takeo Tanaka; Hiroyuki Takashima; Kohei Harada; Keishi Ogura; Ichiro Takemasa
    PloS one, 20, 3, e0320630, 2025, [International Magazine]
    English, Scientific journal
  • Paraspinal Muscle Morphology in Proximal Cervical Spondylotic Amyotrophy.
    Ryosuke Hirota; Hiroyuki Takashima; Makoto Emori; Tsuneo Takebayashi; Atsushi Teramoto
    Cureus, 16, 7, e64255, Jul. 2024, [International Magazine]
    English, Scientific journal
  • Dual Mechanism of Action: Exosomes from Human iPSC-Cardiomyocytes and Mesenchymal Stem Cells Restore Injured Myocardium
    Eileen Tzng; Nathan Bayardo; Gentaro Ikeda; Hiroyuki Takashima; Jennifer Lyons; Mihoko Bennett; Connor G O’Brien; Phillip C. Yang
    Journal of the American Heart Association, 14, 21, e037005, 30 May 2024, [International Magazine]
    English, Scientific journal
  • Platelet-rich plasma does not accelerate the healing of damaged muscle following muscle strain
    Fusagawa, H.; Yamada, T.; Sato, T.; Ashida, Y.; Teramoto, A.; Takashima, H.; Naito, A.; Tokuda, N.; Yamauchi, N.; Ichise, N.; Ogon, I.; Yamashita, T.; Tohse, N.
    Journal of Orthopaedic Research, 42, 6, 1190, 1199, 2024, [International Magazine]
    English, Scientific journal
  • Specific pelvic shape in patients with developmental dysplasia of the hip on 3D morphometric homologous model analysis.
    Yui Sasaki; Daisuke Suzuki; Ryo Tokita; Hiroyuki Takashima; Hirofumi Matsumura; Satoshi Nagoya
    PloS one, 19, 6, e0300938, 2024, [International Magazine]
    English, Scientific journal
  • Mitochondria-Rich Extracellular Vesicles From Stem Cell-Derived Cardiomyocytes Restore Bioenergetic Metabolism of Ischemic Myocardium in a Porcine Chronic Heart Failure Model
    Gentaro Ikeda; Tsuyoshi Ueyama; Eileen Tzng; Hiroyuki Takashima; Jennifer Lyins; Nathan Bayardo; Connor G. OBrien; Phillip C. Yang
    CIRCULATION, 148, 07 Nov. 2023
    English
  • Quantitative assessment of anterior talofibular ligament quality in chronic lateral ankle instability using magnetic resonance imaging T2* value.
    Yoshihiro Akatsuka; Atsushi Teramoto; Yasutaka Murahashi; Katsunori Takahashi; Rui Imamura; Hiroyuki Takashima; Kota Watanabe; Toshihiko Yamashita
    Skeletal radiology, 53, 4, 733, 739, 20 Oct. 2023, [International Magazine]
    English, Scientific journal
  • Coefficient of variation of T2-weighted MRI may predict the prognosis of malignant peripheral nerve sheath tumor.
    Makoto Emori; Hiroyuki Tsuchie; Hiroyuki Takashima; Atsushi Teramoto; Yasutaka Murahashi; Yoshinori Imura; Hidetatsu Outani; Sho Nakai; Satoshi Takenaka; Ryosuke Hirota; Naoya Nakahashi; Junya Shimizu; Kazuyuki Murase; Akira Takasawa; Hiroyuki Nagasawa; Shintaro Sugita; Kohichi Takada; Tadashi Hasegawa; Seiji Okada; Naohisa Miyakoshi; Toshihiko Yamashita
    Skeletal radiology, 53, 4, 657, 664, 27 Sep. 2023, [International Magazine]
    English, Scientific journal, BACKGROUND: We investigated whether non-enhancement MRI features, including measurement of the heterogeneity of the tumor with MR T2 imaging by calculating coefficient of variation (CV) values, were associated with the prognosis of non-metastatic malignant peripheral nerve sheath tumors (MPNST). METHODS: This retrospective study included 42 patients with MPNST who had undergone surgical resection (mean age, 50 years ± 21; 20 male participants). Non-enhancement MR images were evaluated for signal intensity heterogeneity on T1- and T2-weighted imaging, tumor margin definition on T1- and T2-weighted imaging, peritumoral edema on T2-weight imaging, and CV. We measured the signal intensities of MR T2-weighted images and calculated the corresponding CV values. CV is defined as the ratio of the standard deviation to the mean. The associations between factors and overall survival (OS) were investigated via the Kaplan-Meier method with log-rank tests and the Cox proportional hazards model. RESULTS: The mean CV value of MR T2 images was 0.2299 ± 0.1339 (standard deviation) (range, 0.0381-0.8053). Applying receiver operating characteristics analysis, the optimal cut-off level for CV value was 0.137. This cut-off CV value was used for its stratification into high and low CV values. At multivariate survival analysis, a high CV value (hazard ratio = 3.63; 95% confidence interval = 1.16-16.0; p = 0.047) was identified as an independent predictor of OS. CONCLUSION: The CV value of the signal intensity of heterogenous MPNSTs MR T2-weighted images is an independent predictor of patients' OS.
  • Osteophyte Bridge Formation Correlates with Vascular Calcification and Cardiovascular Disease in Diffuse Idiopathic Skeletal Hyperostosis
    Ryosuke Hirota; Atsushi Teramoto; Mitsunori Yoshimoto; Hiroyuki Takashima; Naomi Yasuda; Arihiko Tsukamoto; Noriyuki Iesato; Makoto Emori; Kousuke Iba; Nobuyoshi Kawaharada; Toshihiko Yamashita
    Journal of Clinical Medicine, 12, 16, Aug. 2023, [International Magazine]
    English, Scientific journal
  • Quantitative magnetic resonance spectroscopy and imaging analysis of the lipid content in the psoas major and its association with intervertebral disc degeneration: a cross-sectional study
    Izaya Ogon; Hiroyuki Takashima; Tomonori Morita; Mitsunori Yoshimoto; Tsuneo Takebayashi; Atsushi Teramoto
    Exploration of Musculoskeletal Diseases, 29 Jun. 2023
    Scientific journal
  • Does the L4 nerve root extend during femoral nerve stretch test? A cadaveric study of four cases analyzing the extension rates of the lumbar nerve root.
    Izaya Ogon; Tsuneo Takebayashi; Hironori Chiba; Hiroyuki Takashima; Tomonori Morita; Atsushi Teramoto
    Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 29, 3, 762, 768, 02 Jun. 2023, [Domestic magazines]
    English, Scientific journal
  • Intravoxel Incoherent Motion Factors Affecting Collapse and Nonunion of Osteoporotic Vertebral Fracture.
    Izaya Ogon; Tsuneo Takebayashi; Hiroyuki Takashima; Yasuhisa Abe; Hiroshi Oguma; Rui Imamura; Yoshihiro Akatsuka; Tomonori Morita; Atsushi Teramoto
    Global spine journal, 14, 7, 21925682231167788, 21925682231167788, 31 Mar. 2023, [International Magazine]
    English, Scientific journal
  • T1rho, T2, and T2* relaxation time based on grading of intervertebral disc degeneration.
    Hiroyuki Takashima; Mitsunori Yoshimoto; Izaya Ogon; Tsuneo Takebayashi; Rui Imamura; Yoshihiro Akatsuka; Toshihiko Yamashita
    Acta radiologica (Stockholm, Sweden : 1987), 64, 3, 1116, 1121, Mar. 2023, [Lead author, Corresponding author], [International Magazine]
    English, Scientific journal
  • Comparison of the three-dimensional bone morphology of the first proximal phalanx and first metatarsal between normal and hallux valgus foot using the homologous model technique.
    Kenta Yamatsu; Mizuho Hayashi; Hiroyuki Takashima; Kota Watanabe
    Foot (Edinburgh, Scotland), 54, 101968, 101968, Mar. 2023, [International Magazine]
    English, Scientific journal, Bone morphology is one of the factors involved in hallux valgus development. However, previous studies have not evaluated the overall bone shape in three dimensions. This study aimed to compare the overall shape of the first proximal phalanx and first metatarsal in hallux valgus with those of normal feet.Homologous models were created from computed tomography data of the first proximal phalanx and first metatarsal of 75 healthy men and 53 women in the control group and 10 men and 71 women in the hallux valgus group. Principal component analysis was performed to examine the differences in bone morphology between the control and hallux valgus groups. In men and women with hallux valgus, the proximal articular surface of the first proximal phalanx was characterized by a more lateral inclination and torsion of the pronated first metatarsal. Additionally, the first metatarsal head was characterized by a more lateral inclination in male hallux valgus. This study is the first to reveal the morphological characteristics of the first metatarsal and first proximal phalanx in hallux valgus as a whole bone using a homologous model technique. These characteristics are considered possible causes of hallux valgus development. The shapes of the first proximal phalanx and first metatarsal in hallux valgus were different from those in normal feet. This finding should be useful when considering the pathogenesis and treatment development for hallux valgus.
  • Relationships of cross-sectional area of the thigh muscles before or after total knee arthroplasty with postoperative pain or patient satisfaction: A retrospective, exploratory study
    Akatsuka, Y.; Teramoto, A.; Takashima, H.; Okada, Y.; Watanabe, K.; Yamashita, T.
    Asia-Pacific Journal of Sports Medicine, Arthroscopy, Rehabilitation and Technology, 33, 20, 24, 2023, [International Magazine]
    English, Scientific journal
  • Association of central sensitization, visceral fat, and surgical outcomes in lumbar spinal stenosis
    Ogon, I.; Takashima, H.; Morita, T.; Fukushi, R.; Takebayashi, T.; Teramoto, A.
    Journal of Orthopaedic Surgery and Research, 18, 1, 886, 886, 2023, [International Magazine]
    English, Scientific journal
  • Mitochondria-Rich Extracellular Vesicles From Stem Cell-Derived Cardiomyocytes Restore Cardiac Energy Metabolism of Ischemic Myocardium in a Preclinical Pig Model
    Gentaro Ikeda; Hiroyuki Takashima; Chunli Zhao; Nathan Bayardo; Jennifer Lyins; Connor O'Brien; Phillip C. Yang
    CIRCULATION, 146, Nov. 2022
    English
  • Manganese-Enhanced MRI (MEMRI) Determines the Mechanistic Efficacy of Exosome Therapy in a Porcine Myocardial Infarction Model
    Hiroyuki Takashima; Gentaro Ikeda; Chunli Zhao; Nathan Bayardo; Connor O'Brien; Phillip C. Yang
    CIRCULATION, 146, Nov. 2022, [Lead author]
    English
  • 感染拡大防止を目的とした感染症患者検査時の感染箇所の同定と清拭消毒方法の検討
    高島 弘幸
    医療の広場, 62, 8, 9, 11, (公財)政策医療振興財団, Aug. 2022, [Lead author, Last author, Corresponding author]
    Japanese, 新型コロナウイルス感染症患者の肺炎の重症度などを判断する目的で幅広く利用されているCT検査室における、感染患者対応時の接触感染の原因となる箇所を明らかにすることを目的に、蛍光塗料を塗布したディスポーザブル長袖エプロン及び手袋等を装着した感染模擬患者を、実際の検査時と同様に標準予防策を施した医療者がCT寝台に移乗する介助を行い、実際の診療を想定した行為(酸素投与、造影剤投与、寝台操作および撮影等)後の、CT検査室内及び操作室をブラックライトで照射し、蛍光塗料付着部を汚染箇所としてカメラで撮影し、その箇所及び面積を計測した。その結果、汚染箇所は、とくにCT検査室内で大きく、CT装置の寝台の蛍光塗料付着が最も大きく、以下、造影剤投与インジェクター、ドアノブの順であった。
  • Factors associated with low back pain in patients with lumbar spinal stenosis: a cross-sectional study.
    Izaya Ogon; Atsushi Teramoto; Hiroyuki Takashima; Yoshinori Terashima; Mitsunori Yoshimoto; Makoto Emori; Kousuke Iba; Tsuneo Takebayashi; Toshihiko Yamashita
    BMC musculoskeletal disorders, 23, 1, 552, 552, 08 Jun. 2022, [International Magazine]
    English, Scientific journal
  • 腰部脊柱管狭窄症における腰痛関連因子の解析
    黄金 勲矢; 高島 弘幸; 寺島 嘉紀; 吉本 三徳; 竹林 庸雄; 山下 敏彦
    Journal of Spine Research, 13, 5, 770, 777, (一社)日本脊椎脊髄病学会, May 2022
    Japanese
  • 圧縮センシング併用3D MRIにおけるCS reduction factorが空間分解能に与える影響
    植村 美穂; 中西 光広; 赤塚 吉紘; 今村 塁; 長濱 宏史; 沼澤 香夏子; 高島 弘幸
    北海道放射線技術雑誌, 92, 32, 33, (公社)日本放射線技術学会-北海道支部, Apr. 2022, [Last author]
    Japanese
  • 呼吸同期の有無による圧縮センシング併用4D flow MRIの撮像時間および大動脈血流定量値の比較
    沼澤 香夏子; 中西 光広; 赤塚 吉紘; 今村 塁; 植村 美穂; 鈴木 瑞穂; 高島 弘幸
    北海道放射線技術雑誌, 92, 43, 44, (公社)日本放射線技術学会-北海道支部, Apr. 2022, [Last author]
    Japanese
  • 胸骨骨折否定目的で行ったMRIで肋軟骨損傷と診断された1例
    赤塚 吉紘; 中西 光広; 植村 美穂; 今村 塁; 早川 耕平; 高島 弘幸
    北海道放射線技術雑誌, 92, 50, 51, (公社)日本放射線技術学会-北海道支部, Apr. 2022, [Last author]
    Japanese
  • びまん性特発性骨増殖症罹患と血管石灰化・心血管イベント発症の関連性
    廣田 亮介; 吉本 三徳; 高島 弘幸; 安田 尚美; 川原田 修義; 山下 敏彦
    東日本整形災害外科学会雑誌, 34, 1, 6, 12, 東日本整形災害外科学会, Mar. 2022
    Japanese
  • Effect of Minimally Invasive Selective Laminectomy for Cervical Spondylotic Myelopathy on Degenerative Spondylolisthesis.
    Kota Kurihara; Kousuke Iba; Atsushi Teramoto; Makoto Emori; Ryosuke Hirota; Tsutomu Oshigiri; Izaya Ogon; Noriyuki Iesato; Yoshinori Terashima; Hiroyuki Takashima; Mitsunori Yoshimoto; Tsuneo Takebayashi; Toshihiko Yamashita
    Clinical spine surgery, 35, 1, E242-E247, E247, 01 Feb. 2022, [International Magazine]
    English, Scientific journal
  • Differential diagnosis of fibroma of tendon sheath and giant cell tumor of tendon sheath in the finger using signal intensity on T2 magnetic resonance imaging.
    Makoto Emori; Hiroyuki Takashima; Kousuke Iba; Tomoko Sonoda; Takashi Oda; Tadashi Hasegawa; Toshihiko Yamashita
    Acta radiologica (Stockholm, Sweden : 1987), 62, 12, 1632, 1638, Dec. 2021, [International Magazine]
    English, Scientific journal
  • 足関節外側靱帯における3D MRIシーケンスの比較
    赤塚 吉紘; 寺本 篤史; 高島 弘幸; 中西 光広; 渡邉 耕太; 山下 敏彦
    整形・災害外科, 64, 13, 1705, 1709, 金原出版(株), Dec. 2021
    Japanese
  • MRIの新しい骨イメージング
    高島 弘幸; 山下 敏彦
    整形･災害外科, 64, 9, 1141, 1145, 金原出版, 01 Aug. 2021, [Lead author, Corresponding author]
    Japanese
  • Magnetic Resonance Spectroscopic Analysis of Multifidus Muscle Lipid Contents and Association with Nociceptive Pain in Chronic Low Back Pain.
    Izaya Ogon; Kouske Iba; Hiroyuki Takashima; Mitsunori Yoshimoto; Tomonori Morita; Tsutomu Oshigiri; Yoshinori Terashima; Makoto Emori; Atsushi Teramoto; Tsuneo Takebayashi; Toshihiko Yamashita
    Asian spine journal, 15, 4, 441, 446, Aug. 2021, [International Magazine]
    English, Scientific journal
  • Does renin-angiotensin system inhibition have impacts on muscle mass and bone mineral density in heart failure patients?
    Satoshi Katano; Toshiyuki Yano; Masaki Shimizu; Katsuhiko Ohori; Hidemichi Kouzu; Masayuki Koyama; Ryohei Nagaoka; Takuya Inoue; Yuhei Takamura; Tomoyuki Ishigo; Hiroyuki Takashima; Masaki Katayose; Hirofumi Ohnishi; Tetsuji Miura
    ESC heart failure, 8, 4, 2617, 2624, Aug. 2021, [International Magazine]
    English, Scientific journal
  • 早期変形性膝関節症に対するT2*マッピングを用いた軟骨と半月の定量解析
    今村 塁; 寺本 篤史; 神谷 智昭; 岡田 葉平; 村橋 靖崇; 高島 弘幸; 赤塚 吉紘; 渡邉 耕太; 山下 敏彦
    日本整形外科学会雑誌, 95, 8, S1638, S1638, (公社)日本整形外科学会, Aug. 2021
    Japanese
  • 【痛み-慢性痛研究の最近の話題と将来展望】画像診断 多裂筋の画像診断 Magnetic resonance spectroscopyによる定量的解析
    黄金 勲矢; 高島 弘幸; 山下 敏彦
    医学のあゆみ, 278, 1, 38, 42, 医歯薬出版(株), Jul. 2021
    Japanese
  • 【腰痛の発生・慢性化のメカニズム】慢性腰痛に関する定量的MRIを用いた画像的検討
    黄金 勲矢; 高島 弘幸; 寺島 嘉紀; 吉本 三徳; 竹林 庸雄; 山下 敏彦
    Journal of Spine Research, 12, 6, 819, 824, (一社)日本脊椎脊髄病学会, Jun. 2021
    Japanese
  • Evaluation of a Polyethylene Glycol Phantom for Measuring Apparent Diffusion Coefficients Using Three 3.0 T MRI Systems
    Eisuke Sato; Kei Fukuzawa; Hiroyuki Takashima; Yuya Yamatani; Yasuo Takatsu; Junichi Hata; Keigo Hikishima; Kenta Miwa
    Applied Magnetic Resonance, 52, 5, 619, 631, May 2021
    English, Scientific journal
  • Accumulation of Macromolecules in Idiopathic Normal Pressure Hydrocephalus.
    Yukinori Akiyama; Rintaro Yokoyama; Hiroyuki Takashima; Yuka Kawata; Masayasu Arihara; Ryohei Chiba; Yusuke Kimura; Takeshi Mikami; Nobuhiro Mikuni
    Neurologia medico-chirurgica, 61, 3, 211, 218, 15 Mar. 2021, [Domestic magazines]
    English, Scientific journal
  • Association between lumbar segmental mobility and intervertebral disc degeneration quantified by magnetic resonance imaging T2 mapping.
    Izaya Ogon; Kousuke Iba; Hiroyuki Takashima; Yoshinori Terashima; Mitsunori Yoshimoto; Makoto Emori; Atsushi Teramoto; Tsuneo Takebayashi; Toshihiko Yamashita
    North American Spine Society journal, 5, 100044, 100044, Mar. 2021, [International Magazine]
    English, Scientific journal, BACKGROUND: The relation between segmental mobility and degree of lumbar degenerative change is still unknown. This cross-sectional study aimed to elucidate the association between intervertebral disc degeneration (IVDD) and segmental mobility in chronic low back pain using magnetic resonance imaging (MRI) T2 mapping. METHODS: Subjects comprised 60 patients (29 men, 31 women; mean age, 61.8 ± 1.9 years; range, 41-79 years). T2 values of the anterior annulus fibrosus (AF), the nucleus pulposus (NP) and the posterior AF were evaluated with MRI T2 mapping. Facet joint degeneration was divided into 4 grades using MRI. We analyzed the correlation between segmental mobility and T2 values of anterior AF, NP and posterior AF using multiple linear regression analysis adjusted for age and facet joint degeneration. RESULTS: The standardized partial regression coefficient of the anterior AF, NP and posterior AF T2 values were 0.125 (p=0.72), 0.499 (p<0.01) and -0.026 (p=0.11), respectively, for the L1-2 level; 0.102 (p=0.27), 0.395 (p<0.01) and -0.094 (p=0.20), respectively, for the L2-3 level; 0.108 (p=0.38), 0.415 (p<0.01) and -0.050 (p=0.51), respectively, for the L3-4 level; 0.124 (p=0.09), 0.396 (p<0.01) and 0.025 (p=0.73), respectively, for the L4-5 level; and 0.011 (p=0.89), 0.443 (p<0.01) and 0.030 (p=0.72), respectively, for the L5-S level. There was a significantly positive correlation between segmental mobility and the T2 values of NP at L1-L2, L2-L3, L3-L4, L4-L5, and L5-S1. No significant correlations arose between segmental mobility and the T2 values of the anterior AF and the posterior AF at L1-L2, L2-L3, L3-L4, L4-L5, and L5-S1. CONCLUSION: Characterization of the relationship between NP degeneration and lumbar segmental mobility may enhance our ability to evaluate the changes seen in kinematics of functional spinal unit.
  • Visualization of cerebellar peduncles using diffusion tensor imaging.
    Hiroshi Nagahama; Masahiko Wanibuchi; Toru Hirano; Mitsuhiro Nakanishi; Hiroyuki Takashima
    Acta neurochirurgica, 163, 3, 619, 624, Mar. 2021, [Last author], [International Magazine]
    English, Scientific journal
  • Optimal acceleration factor for image acquisition in turbo spin echo: diffusion-weighted imaging with compressed sensing.
    Hiroyuki Takashima; Mitsuhiro Nakanishi; Rui Imamura; Yoshihiro Akatsuka; Hiroshi Nagahama; Izaya Ogon
    Radiological physics and technology, 14, 1, 100, 104, Mar. 2021, [Lead author, Corresponding author], [Domestic magazines]
    English, Scientific journal
  • Associations between visceral fat chronic low back pain and central sensitization in patients with lumbar spinal stenosis.
    Izaya Ogon; Atsushi Teramoto; Hiroyuki Takashima; Yoshinori Terashima; Mitsunori Yoshimoto; Makoto Emori; Kousuke Iba; Tsuneo Takebayashi; Toshihiko Yamashita
    Journal of back and musculoskeletal rehabilitation, 35, 5, 1035, 1041, 16 Feb. 2021, [International Magazine]
    English, Scientific journal
  • Relationship Between Plantar Callosity and Foot Deformity in Hallux Valgus Using Weightbearing Computed Tomography.
    Yasutaka Murahashi; Kousuke Iba; Atsushi Teramoto; Katsunori Takahashi; Yohei Okada; Tomoaki Kamiya; Hiroyuki Takashima; Kota Watanabe; Hirofumi Ohnishi; Toshihiko Yamashita
    The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons, 60, 6, 1207, 1211, 2021, [International Magazine]
    English, Scientific journal
  • 早期・初期変形性膝関節症における内側半月後節と関節軟骨のT2*値の関連
    今村 塁; 高島 弘幸; 赤塚 吉紘; 寺本 篤史; 神谷 智昭; 岡田 葉平; 村橋 靖崇; 山下 敏彦; 渡邉 耕太
    北海道整形災害外科学会雑誌, 63, 139th suppl, 35, 35, 北海道整形災害外科学会, 2021
    Japanese
  • Clinical Risk Factors and Prognostic Impact of Osteoporosis in Patients With Chronic Heart Failure.
    Satoshi Katano; Toshiyuki Yano; Takanori Tsukada; Hidemichi Kouzu; Suguru Honma; Takuya Inoue; Yuhei Takamura; Ryohei Nagaoka; Tomoyuki Ishigo; Ayako Watanabe; Katsuhiko Ohori; Masayuki Koyama; Nobutaka Nagano; Takefumi Fujito; Ryo Nishikawa; Hiroyuki Takashima; Akiyoshi Hashimoto; Masaki Katayose; Tetsuji Miura
    Circulation journal : official journal of the Japanese Circulation Society, 84, 12, 2224, 2234, 25 Nov. 2020, [Domestic magazines]
    English, Scientific journal
  • Bioabsorbable interference screws can be used with less tunnel widening in anatomic rectangular tunnel anterior cruciate ligament reconstruction with a bone-patellar-tendon-bone graft.
    Kousuke Shiwaku; Tomoyuki Suzuki; Takashi Matsumura; Hiroyuki Takashima; Hidenori Otsubo; Toshihiko Yamashita
    The Knee, 27, 5, 1293, 1299, Oct. 2020, [International Magazine]
    English, Scientific journal
  • Is the Lipid Content of the Psoas Major Correlated with Chronic Low Back Pain and Spinopelvic Alignment? A Magnetic Resonance Spectroscopic Study.
    Izaya Ogon; Hiroyuki Takashima; Tomonori Morita; Tsutomu Oshigiri; Yoshinori Terashima; Mitsunori Yoshimoto; Makoto Emori; Atsushi Teramoto; Tsuneo Takebayashi; Toshihiko Yamashita
    Asian spine journal, 14, 4, 430, 437, Aug. 2020, [International Magazine]
    English, Scientific journal
  • Lumbar disc degeneration assessment using T2* relaxation time with ultra-short TE.
    Hiroyuki Takashima; Mitsunori Yoshimoto; Izaya Ogon; Yoshinori Terashima; Rui Imamura; Yoshihiro Akatsuka; Noriyuki Iesato; Tsutomu Oshigiri; Tomonori Morita; Tsuneo Takebayashi; Makoto Emori; Atsushi Teramoto; Toshihiko Yamashita
    Magnetic resonance imaging, 73, 11, 14, 14 Jul. 2020, [Lead author, Corresponding author], [International Magazine]
    English, Scientific journal
  • MRI拡散強調像における前臨床研究のための画像評価用ファントムの開発
    高島 弘幸
    医療の広場, 60, 7, 8, 10, (公財)政策医療振興財団, Jul. 2020, [Lead author, Last author, Corresponding author]
    Japanese
  • Efficacy of non-rigid registration technique for misregistration in 3D-CTA fusion imaging.
    Yoshiya Ohashi; Hiroyuki Takashima; Goh Ohmori; Kohei Harada; Ayaka Chiba; Kanako Numasawa; Tatsuya Imai; Shun Hayasaka; Aya Itoh
    La Radiologia medica, 125, 7, 618, 624, Jul. 2020, [Corresponding author], [International Magazine]
    English, Scientific journal
  • 慢性腰痛患者における腰痛の改善に伴う多裂筋の筋細胞内脂肪の変化
    高島 弘幸; 黄金 勲矢; 竹林 庸雄; 押切 勉; 森田 智慶; 吉本 三徳; 寺島 嘉紀; 山下 敏彦
    Journal of Spine Research, 11, 6, 897, 901, (一社)日本脊椎脊髄病学会, Jun. 2020, [Lead author, Corresponding author]
    Japanese
  • 圧縮センシングMRIは心筋T1mappingの空間分解能向上に貢献できるか
    中西 光広; 赤塚 吉紘; 今村 塁; 長濱 宏史; 高島 弘幸
    北海道放射線技術雑誌, 88, 48, 49, (公社)日本放射線技術学会-北海道支部, Apr. 2020, [Last author]
    Japanese
  • 脳の圧縮センシングMRI 三次元等方性ボクセルスピンエコーの撮像時間は半減する
    長濱 宏史; 今村 塁; 赤塚 吉紘; 中西 光広; 高島 弘幸
    北海道放射線技術雑誌, 88, 10, 11, (公社)日本放射線技術学会-北海道支部, Apr. 2020, [Last author]
    Japanese
  • 圧縮センシングMRIによる高倍速化が3D-TSE画像の解像度に与える影響
    今村 塁; 高島 弘幸; 中西 光広; 長濱 宏史; 赤塚 吉紘
    北海道放射線技術雑誌, 88, 46, 47, (公社)日本放射線技術学会-北海道支部, Apr. 2020
    Japanese
  • 拡散強調像における圧縮センシングの併用はどこまで許容できるか
    高島 弘幸; 中西 光広; 長濱 宏史; 今村 塁; 赤塚 吉紘
    北海道放射線技術雑誌, 88, 58, 59, (公社)日本放射線技術学会-北海道支部, Apr. 2020, [Lead author, Corresponding author]
    Japanese
  • APT-CESTにおける卵白粉を用いたpHイメージングの検討
    赤塚 吉紘; 高島 弘幸; 今村 塁; 長濱 宏史; 中西 光広
    北海道放射線技術雑誌, 88, 60, 61, (公社)日本放射線技術学会-北海道支部, Apr. 2020
    Japanese
  • Relevance between Schmorl's Node and Lumbar Intervertebral Disc Degeneration Quantified with Magnetic Resonance Imaging T2 Mapping in Chronic Low Back Pain.
    Izaya Ogon; Hiroyuki Takashima; Tomonori Morita; Tsutomu Oshigiri; Yoshinori Terashima; Mitsunori Yoshimoto; Ryunosuke Fukushi; Shutaro Fujimoto; Makoto Emori; Atsushi Teramoto; Tsuneo Takebayashi; Toshihiko Yamashita
    Asian spine journal, 14, 5, 621, 628, 30 Mar. 2020, [International Magazine]
    English, Scientific journal
  • MR Spectroscopyを用いた尾部懸垂ラットにおける骨格筋脂肪の解析
    高島 弘幸; 黄金 勲矢; 寺島 嘉紀; 射場 浩介; 長濱 宏史; 山下 敏彦
    日本放射線技術学会総会学術大会予稿集, 76回, 253, 253, (公社)日本放射線技術学会, Mar. 2020, [Lead author, Corresponding author]
    Japanese
  • Imaging diagnosis for intervertebral disc.
    Izaya Ogon; Tsuneo Takebayashi; Hiroyuki Takashima; Tomonori Morita; Yoshinori Terashima; Mitsunori Yoshimoto; Toshihiko Yamashita
    JOR spine, 3, 1, e1066, Mar. 2020, [International Magazine]
    English, Scientific journal
  • 足部・足関節の画像解析-画像解析による病態の解明- 3D MRIによる足関節外側靱帯の評価
    寺本 篤史; 赤塚 吉紘; 今村 塁; 高島 弘幸; 神谷 智昭; 渡邉 耕太; 山下 敏彦
    日本整形外科学会雑誌, 94, 2, S45, S45, (公社)日本整形外科学会, Mar. 2020
    Japanese
  • TKA術前下腿筋量は術後DVT発生に関連するか
    赤塚 吉紘; 寺本 篤史; 高島 弘幸; 岡田 葉平; 神谷 智昭; 渡邉 耕太; 山下 敏彦
    日本整形外科学会雑誌, 94, 3, S766, S766, (公社)日本整形外科学会, Mar. 2020
    Japanese
  • Denosumab prevents periprosthetic bone mineral density loss in the tibial metaphysis in total knee arthroplasty.
    Yasutaka Murahashi; Atsushi Teramoto; Shunsuke Jimbo; Yohei Okada; Tomoaki Kamiya; Rui Imamura; Hiroyuki Takashima; Kota Watanabe; Satoshi Nagoya; Toshihiko Yamashita
    The Knee, 27, 2, 580, 586, Mar. 2020, [International Magazine]
    English, Scientific journal
  • 【腰痛診療perspective】腰痛の新しい画像診断の取り組み MR spectroscopyで評価した多裂筋脂肪変性と非特異的腰痛の関連
    黄金 勲矢; 高島 弘幸; 山下 敏彦
    Pharma Medica, 38, 1, 49, 53, (株)メディカルレビュー社, Jan. 2020
    Japanese
  • Association between Spinopelvic Alignment and Lumbar Intervertebral Disc Degeneration Quantified with Magnetic Resonance Imaging T2 Mapping in Patients with Chronic Low Back Pain.
    Izaya Ogon; Hiroyuki Takashima; Tomonori Morita; Tsutomu Oshigiri; Yoshinori Terashima; Mitsunori Yoshimoto; Tsuneo Takebayashi; Toshihiko Yamashita
    Spine surgery and related research, 4, 2, 135, 141, 2020, [Domestic magazines]
    English, Scientific journal
  • [Knowledge Obtained from Process of Research-Does JSRT Really Aim for Society of Researcher?].
    Hiroyuki Takashima
    Nihon Hoshasen Gijutsu Gakkai zasshi, 76, 5, I, 2020, [Lead author], [Domestic magazines]
    Japanese, Scientific journal
  • TKA術前下腿筋量は術後DVT発生に関連するか
    赤塚 吉紘; 高島 弘幸; 寺本 篤史; 岡田 葉平; 神谷 智昭; 山下 敏彦; 渡邉 耕太
    北海道整形災害外科学会雑誌, 62, 138th suppl, 76, 76, 北海道整形災害外科学会, 2020
    Japanese
  • 退行性疾患における椎間板変性と多裂筋断面積は相関する
    藤田 直輝; 三木 貴弘; 渡邊 勇太; 高島 弘幸; 竹林 庸雄; 小熊 大士; 阿部 恭久; 鈴木 智之; 大西 史師; 黒田 未来; 山崎 生久男; 山村 恵
    北海道整形災害外科学会雑誌, 62, 138th suppl, 13, 13, 北海道整形災害外科学会, 2020
    Japanese
  • Associations between Paraspinal Muscle Morphology, Disc Degeneration, and Clinical Features in Patients with Lumbar Spinal Stenosis.
    Takahiro Miki; Fujita Naoki; Hiroyuki Takashima; Tsuneo Takebayashi
    Progress in rehabilitation medicine, 5, 20200015, 20200015, 2020, [Domestic magazines]
    English, Scientific journal, Objective: The purpose of this study was to examine the relationships between intervertebral disc degeneration in the lumbar spine, paraspinal muscle morphology, and clinical features in patients with lumbar spinal stenosis (LSS). Methods: A total of 52 patients with LSS participated in this study. Magnetic resonance imaging was used to assess intervertebral disc degeneration at L4/5 and to measure the standardized cross-sectional areas (SCSAs) of the multifidus and erector spinae muscles. The intensity of low back pain (LBP) and lower limb pain, the level of disability, and the quality of life (QoL) were evaluated using patient-reported outcome measures. The associations between the image findings and clinical features, including the disability score, the pain score for low back pain, and the QoL score, were calculated using Spearman's rank correlation coefficient. Results: No associations were found between disc degeneration and clinical features. However, disc degeneration and the SCSA of the multifidus muscle (r=-0.38, P <0.01) and of the erector spinae muscle (r=-0.29, P=0.04) were significantly associated. Analysis of the associations between muscle morphology and clinical features found that the SCSA of the multifidus muscle was associated with LBP (r=0.31, P=0.03). Conclusions: These results suggest that there is some correlation between atrophy of the multifidus and pain intensity. Consequently, focusing on the CSA of the multifidus muscle may help to clarify the causes of LBP in patients with LSS. However, because of the cross-sectional nature of this study, causal relationships could not be determined and further research is needed.
  • 3D MRI evaluation of morphological characteristics of lateral ankle ligaments in injured patients and uninjured controls.
    Atsushi Teramoto; Yoshihiro Akatsuka; Hiroyuki Takashima; Hiroaki Shoji; Yuzuru Sakakibara; Kota Watanabe; Toshihiko Yamashita
    Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 25, 1, 183, 187, Jan. 2020, [Domestic magazines]
    English, Scientific journal
  • Do We Have Adequate Flexion-extension Radiographs for Evaluating Instability in Patients With Lumbar Spondylolisthesis?
    Tomonori Morita; Mitsunori Yoshimoto; Yoshinori Terashima; Katsumasa Tanimoto; Noriyuki Iesato; Izaya Ogon; Tsutomu Oshigiri; Atsushi Teramoto; Makoto Emori; Hiroyuki Takashima; Ryosuke Hirota; Shutaro Fujimoto; Toshihiko Yamashita
    Spine, 45, 1, 48, 54, 01 Jan. 2020, [International Magazine]
    English, Scientific journal
  • Glossopharyngeal and Hypoglossal Nerve Paralysis Secondary to Prevertebral Phlegmon.
    Ryunosuke Fukushi; Izaya Ogon; Yoshinori Terashima; Hiroyuki Takashima; Tsutomu Oshigiri; Noriyuki Iesato; Mitsunori Yoshimoto; Makoto Emori; Atsushi Teramoto; Toshihiko Yamashita
    Case reports in orthopedics, 2020, 3795035, 3795035, 2020, [International Magazine]
    English, A 50-year-old man presented to the clinic with severe neck pain, fever, and difficulty breathing and was subsequently admitted to the local orthopedics department with possible retropharyngeal abscess and pyogenic spondylitis. Antibiotic therapy was initiated; however, due to poor oxygenation, he was referred and transferred to our department and admitted. Magnetic resonance imaging showed signal changes at the left C1/2 lateral atlantoaxial joint, posterior pharynx, longus colli muscle, carotid space, and medial deep cervical region, predominantly on the left side. In addition, despite lymph node enlargement from the posterior pharynx to the deep cervical region, there was no abscess formation. There were no signs of a space-occupying lesion or signal changes in the jugular foramen. One day postadmission, the patient's temperature had risen to 39.1°C and his SpO2 had fallen. His neck pain had also worsened, and emergency surgery was decided. Preoperatively, we suspected retropharyngeal abscess and pyogenic spondylitis. On day 13 postadmission, the patient exhibited dysphagia, deviated tongue protrusion, and the curtain sign. Glossopharyngeal and hypoglossal nerve paralysis were diagnosed. The patient's swallowing functions recovered and he was discharged on day 36. We experienced a case of glossopharyngeal and hypoglossal nerve paralysis secondary to pyogenic cervical facet joint arthritis.
  • 腰部脊柱管狭窄症における椎間板変性および脊柱筋群断面積と疼痛、機能障害、QOLとの関連の検討
    藤田 直輝; 三木 貴弘; 高島 弘幸; 竹林 庸雄
    Journal of Musculoskeletal Pain Research, 11, 4, S59, S59, (一社)日本運動器疼痛学会, Nov. 2019, [Peer-reviewed]
    Japanese
  • 新しい医療技術 Dual energy CT
    高島 弘幸; 小倉 圭史; 山下 敏彦
    整形･災害外科, 62, 11, 1399, 1402, 金原出版, 01 Oct. 2019, [Lead author, Corresponding author]
    Japanese
  • 足関節外側靱帯におけるMRI 3Dシーケンスの比較
    赤塚 吉紘; 寺本 篤史; 高島 弘幸; 今村 塁; 中西 光広; 神谷 智昭; 渡邉 耕太; 山下 敏彦
    日本整形外科学会雑誌, 93, 8, S1734, S1734, (公社)日本整形外科学会, Sep. 2019
    Japanese
  • 造影剤の到達遅延症例におけるBT法のトリガーCT値の検討
    大橋 芳也; 原田 耕平; 千葉 彩佳; 沼澤 香夏子; 今井 達也; 早坂 駿; 高島 弘幸
    日本放射線技術学会雑誌, 75, 9, 1076, 1076, (公社)日本放射線技術学会, Sep. 2019, [Peer-reviewed], [Last author]
    Japanese
  • Magnetic resonance spectroscopyを用いた多裂筋の画像診断
    黄金 勲矢; 竹林 庸雄; 高島 弘幸; 森田 智慶; 寺島 嘉紀; 吉本 三徳; 山下 敏彦
    北海道整形災害外科学会雑誌, 61, 1, 19, 22, 北海道整形災害外科学会, Aug. 2019
    Japanese
  • Multifidus Muscles Lipid Content Is Associated with Intervertebral Disc Degeneration: A Quantitative Magnetic Resonance Imaging Study.
    Izaya Ogon; Tsuneo Takebayashi; Hiroyuki Takashima; Tomonori Morita; Tsutomu Oshigiri; Yoshinori Terashima; Mitsunori Yoshimoto; Toshihiko Yamashita
    Asian spine journal, 13, 4, 601, 607, Aug. 2019, [International Magazine]
    English, Scientific journal
  • Optimizing T1rho and T2 Values for Intervertebral Discs Obtained from the Combined T1rho and T2 Sequence
    Imamura Rui; Takashima Hiroyuki; Nakanishi Mitsuhiro; Akatsuka Yoshihiro; Nagahama Hiroshi; Okuaki Tomoyuki; Yoneyama Masami; Hatakenaka Masamitsu
    APPLIED MAGNETIC RESONANCE, 50, 8, 959, 966, Aug. 2019, [Peer-reviewed]
    English, Scientific journal
  • 3D MRI斜位断面による遠位脛腓靱帯結合の描出能
    寺本 篤史; 赤塚 吉紘; 小路 弘晃; 高島 弘幸; 神谷 智昭; 渡邉 耕太; 山下 敏彦
    日本足の外科学会雑誌, 40, Suppl., S309, S309, (一社)日本足の外科学会, Jul. 2019
    Japanese
  • 【腰痛の真理追求と明るい未来へ】MRI T2*を用いた高度変性椎間板の定量的評価と腰痛の関連性
    高島 弘幸; 吉本 三徳; 竹林 庸雄; 家里 典幸; 今村 塁; 赤塚 吉紘; 寺島 嘉紀; 谷本 勝正; 黄金 勲矢; 山下 敏彦
    Journal of Spine Research, 10, 6, 944, 947, (一社)日本脊椎脊髄病学会, Jun. 2019, [Lead author, Corresponding author]
    Japanese
  • Analysis of Neuropathic Pain Using Magnetic Resonance Imaging T2 Mapping of Intervertebral Disc in Chronic Low Back Pain.
    Izaya Ogon; Tsuneo Takebayashi; Hiroyuki Takashima; Tomonori Morita; Noriyuki Iesato; Katsumasa Tanimoto; Yoshinori Terashima; Mitsunori Yoshimoto; Toshihiko Yamashita
    Asian spine journal, 13, 3, 403, 409, Jun. 2019, [International Magazine]
    English, Scientific journal
  • 骨付き膝蓋腱を用いた長方形骨孔前十字靱帯再建術における生体吸収スクリューの安全性の検討
    塩泡 孝介; 鈴木 智之; 松村 崇史; 山下 敏彦; 高島 弘幸; 大坪 英則
    整形・災害外科, 62, 6, 791, 796, 金原出版(株), May 2019
    Japanese
  • Quantitative Analysis Concerning Atrophy and Fat Infiltration of the Multifidus Muscle with Magnetic Resonance Spectroscopy in Chronic Low Back Pain.
    Izaya Ogon; Tsuneo Takebayashi; Hiroyuki Takashima; Tomonori Morita; Mitsunori Yoshimoto; Yoshinori Terashima; Toshihiko Yamashita
    Spine surgery and related research, 3, 2, 163, 170, 27 Apr. 2019, [Domestic magazines]
    English, Scientific journal
  • 【整形外科診療における最先端技術】診断、評価 新しい画像・機能診断 MRI定量的画像法(T1ρ、T2、T2*)による椎間板変性の評価
    高島 弘幸; 吉本 三徳; 竹林 庸雄; 今村 塁; 赤塚 吉紘; 山下 敏彦
    別冊整形外科, 75, 16, 19, (株)南江堂, Apr. 2019, [Lead author, Corresponding author]
    Japanese
  • 椎体骨折におけるintravoxel incoherent motion(IVIM)パラメータの解析
    今村 塁; 高島 弘幸; 竹林 庸雄; 吉中 宣康; 赤塚 吉紘
    北海道放射線技術雑誌, 86, 34, 35, (公社)日本放射線技術学会-北海道支部, Apr. 2019
    Japanese
  • 足関節外側靱帯 isotropic 3D fast spin-echoとbalanced fast field-echoの比較
    赤塚 吉紘; 高島 弘幸; 今村 塁; 中西 光広
    北海道放射線技術雑誌, 86, 44, 45, (公社)日本放射線技術学会-北海道支部, Apr. 2019
    Japanese
  • 胃CT perfusionにおける撮影間隔による解析精度の評価
    沼澤 香夏子; 原田 耕平; 大橋 芳也; 千葉 彩佳; 今井 達也; 早坂 駿; 大森 剛; 伊藤 彩; 高島 弘幸
    北海道放射線技術雑誌, 86, 30, 31, (公社)日本放射線技術学会-北海道支部, Apr. 2019, [Peer-reviewed], [Last author]
    Japanese
  • Optimization of MR Signal Contrast of the Lumbar Cartilaginous Endplates Using Ultra-Short TE
    Hiroyuki Takashima; Mika Yanagida; Rui Imamura; Mitsunori Yoshimoto; Izaya Ogon; Mitsuhiro Nakanishi; Yoshihiro Akatsuka; Tomoyuki Okuaki; Masami Yoneyama; Masamitsu Hatakenaka; Toshihiko Yamashita
    APPLIED MAGNETIC RESONANCE, 50, 1-3, 381, 389, Mar. 2019
    English, Scientific journal
  • 3D MRIを用いた足関節外側靱帯の腓骨側付着部の検討
    赤塚 吉紘; 寺本 篤史; 高島 弘幸; 神谷 智昭; 渡邉 耕太; 山下 敏彦
    日本整形外科学会雑誌, 93, 2, S153, S153, (公社)日本整形外科学会, Mar. 2019
    Japanese
  • Morphological evaluation of the calcaneofibular ligament in different ankle positions using a three-dimensional MRI sequence.
    Yoshihiro Akatsuka; Atsushi Teramoto; Hiroyuki Takashima; Kota Watanabe; Toshihiko Yamashita
    Surgical and radiologic anatomy : SRA, 41, 3, 307, 311, Mar. 2019, [International Magazine]
    English, Scientific journal
  • 足関節外側靱帯におけるMRI 3Dシーケンスの比較
    赤塚 吉紘; 高島 弘幸; 今村 塁; 中西 光広; 寺本 篤史; 神谷 智昭; 山下 敏彦; 渡邉 耕太
    北海道整形災害外科学会雑誌, 61, 137th suppl, 69, 69, 北海道整形災害外科学会, 2019
    Japanese
  • 【腰痛治療の最前線】腰痛の診断 MRIを用いた腰痛の可視化の可能性
    高島 弘幸; 山下 敏彦
    関節外科, 37, 12, 1310, 1317, (株)メジカルビュー社, Dec. 2018, [Lead author, Corresponding author]
    Japanese
  • Differentiating spinal intradural-extramedullary schwannoma from meningioma using MRI T2 weighted images.
    Hiroyuki Takashima; Tsuneo Takebayashi; Mitsunori Yoshimoto; Maki Onodera; Yoshinori Terashima; Noriyuki Iesato; Katsumasa Tanimoto; Izaya Ogon; Tomonori Morita; Toshihiko Yamashita
    The British journal of radiology, 91, 1092, 20180262, 20180262, Dec. 2018, [Lead author, Corresponding author], [International Magazine]
    English, Scientific journal
  • The Difference in Gender Affects the Pathogenesis of Ligamentum Flavum Hypertrophy.
    Hiroyuki Takashima; Tsuneo Takebayashi; Mitsunori Yoshimoto; Maki Onodera; Izaya Ogon; Tomonori Morita; Noriyuki Iesato; Yoshinori Terashima; Katsumasa Tanimoto; Toshihiko Yamashita
    Spine surgery and related research, 2, 4, 263, 269, 26 Oct. 2018, [Lead author, Corresponding author], [Domestic magazines]
    English, Scientific journal
  • 男性骨盤の前方CE角は年齢とともに増大する
    鈴木 大輔; 名越 智; 岡崎 俊一郎; 喜沢 史弥; 高島 弘幸; 舘田 健児; 小助川 維摩; 佐々木 幹人; 山下 敏彦
    北海道整形災害外科学会雑誌, 60, 1, 149, 150, 北海道整形災害外科学会, Aug. 2018
    Japanese
  • Cutting Edge on Clinical Management of Chronic Lateral Ankle Instability MR Imaging of Chronic Lateral Ankle Instability MRIで何がわかるか
    寺本 篤史; 赤塚 吉紘; 高島 弘幸; 小路 弘晃; 榊原 醸; 神谷 智昭; 渡邉 耕太; 山下 敏彦
    JOSKAS, 43, 4, 456, 456, (一社)日本関節鏡・膝・スポーツ整形外科学会, May 2018
    Japanese
  • TKA術前および術後における大腿筋断面積と術後の疼痛・満足度との関係
    赤塚 吉紘; 高島 弘幸; 今村 塁; 寺本 篤史; 鈴木 智之; 岡田 葉平; 木井 雄一郎; 山下 敏彦; 渡邉 耕太
    北海道整形災害外科学会雑誌, 59, 2, 285, 285, 北海道整形災害外科学会, Mar. 2018
    Japanese
  • Analysis of intra and extramyocellular lipids in the multifidus muscle in patients with chronic low back pain using MR spectroscopy
    Hiroyuki Takashima; Tsuneo Takebayashi; Izaya Ogon; Mitsunori Yoshimoto; Tomonori Morita; Rui Imamura; Mitsuhiro Nakanishi; Hiroshi Nagahama; Yoshinori Terashima; Toshihiko Yamashita
    British Journal of Radiology, 91, 1083, 20170536, 20170536, 2018, [Peer-reviewed], [Lead author, Corresponding author], [International Magazine]
    English, Scientific journal
  • 男性骨盤の前方CE 角は年齢とともに増大する
    鈴木大輔; 名越智; 喜沢史弥; 高島弘幸; 舘田健児; 小助川維摩; 佐々木幹人; 岡崎俊一郎; 山下敏彦
    Hip Joint, 44, 1, 309, 313, 日本股関節学会, 2018
    Japanese, Scientific journal, 大腿骨被覆は股関節疾患と深い関わりがあり、近年は大腿骨寛骨臼インピンジメント(FAI)と骨形態の関わりが多く研究されている。FAIの臨床症状として、股関節の前部痛、屈曲内旋で痛み増強などが挙げられ、これらは股関節前方の骨形態と強く関連している。著者等は以前、正常股関節例のherniation pit存在率について調査し、50～60歳代で最も高かった。これらのことから、正常人の大腿骨の前方被覆は高齢になると変化するのではないかと考え、検証を行った。方法は、当院に検診目的で来院した日本人120名(男性60名、女性60名、年齢15～79歳)のCT画像を用い、3D画像ソフトで三次元構築し、「骨盤傾斜」「前方CE角」「後方CE角」を計測した。その結果、男女とも加齢に伴って骨盤が有意に後傾し、また男性のみ加齢に伴って前方CE角が有意に増大した。前方CE角の増大はFAIの発生に関係している可能性が示唆された。
  • Three cases of implantation of a SureScan(A (R)) system and MRI for investigating causes of pain
    Kazunobu Takahashi; Atsushi Sawada; Soshi Iwasaki; Naoya Yama; Hiroyuki Takashima; Maki Onodera; Masamitsu Hatakenaka; Michiaki Yamakage
    JOURNAL OF ANESTHESIA, 31, 6, 915, 917, Dec. 2017, [Peer-reviewed], [Domestic magazines]
    English, Scientific journal
  • 特集 高齢者脊椎疾患の診断･治療の最近の進歩 診断 MRIによる定量的画像解析法を用いた椎間板および傍脊柱筋の解析
    高島 弘幸; 山下 敏彦
    関節外科, 36, 14, 19, 25, (株)メジカルビュー社, 01 Oct. 2017, [Lead author, Corresponding author]
    Japanese
  • 変形性足関節症モデルラットにおけるヒアルロン酸ナトリウムの効果
    神保 俊介; 寺島 嘉紀; 竹林 庸雄; 黄金 勲矢; 高島 弘幸; 寺本 篤史; 渡邉 耕太; 當瀬 規嗣; 山下 敏彦
    Journal of Musculoskeletal Pain Research, 9, 3, S34, S34, (一社)日本運動器疼痛学会, Oct. 2017
    Japanese
  • Three-dimensional orientation of the acetabulum
    Daisuke Suzuki; Satoshi Nagoya; Hiroyuki Takashima; Kenji Tateda; Toshihiko Yamashita
    CLINICAL ANATOMY, 30, 6, 753, 760, Sep. 2017, [Peer-reviewed], [International Magazine]
    English, Scientific journal
  • 日本人正常寛骨臼による三次元大腿骨被覆
    鈴木 大輔; 名越 智; 高島 弘幸; 舘田 健児; 小助川 維摩; 佐々木 幹人; 岡崎 俊一郎; 山下 敏彦
    日本整形外科学会雑誌, 91, 8, S1545, S1545, (公社)日本整形外科学会, Aug. 2017
    Japanese
  • ストレス撮影は必要である 踵腓靱帯に着目した新たな画像診断ツール3D MRIに加えて
    寺本 篤史; 赤塚 吉紘; 高島 弘幸; 渡邉 耕太; 山下 敏彦
    日本整形外科スポーツ医学会雑誌, 37, 2, 116, 119, (一社)日本整形外科スポーツ医学会, May 2017
    Japanese
  • プリパルス印加型連結T1rho/T2マッピングシーケンスにおける印加時間が計測値に与える影響
    今村 塁; 高島 弘幸; 奥秋 知幸; 中西 光広; 宍戸 博紀; 赤塚 吉紘
    北海道放射線技術雑誌, 82, 71, 72, (公社)日本放射線技術学会-北海道支部, Mar. 2017
    Japanese
  • MRI depiction and 3D visualization of three anterior cruciate ligament bundles.
    H Otsubo; Y Akatsuka; H Takashima; T Suzuki; D Suzuki; T Kamiya; Y Ikeda; T Matsumura; T Yamashita; K Shino
    Clinical anatomy (New York, N.Y.), 30, 2, 276, 283, Mar. 2017, [International Magazine]
    English, Scientific journal
  • 寛骨臼形成不全患者と正常者の後方被覆の比較
    鈴木 大輔; 喜沢 史弥; 名越 智; 高島 弘幸; 舘田 健児; 小助川 維摩; 佐々木 幹人; 岡崎 俊一郎; 山下 敏彦
    日本整形外科学会雑誌, 91, 2, S533, S533, (公社)日本整形外科学会, Mar. 2017
    Japanese
  • 人工膝関節置換術後の疼痛と術前大腿部筋断面積の関係
    赤塚 吉紘; 高島 弘幸; 今村 塁; 寺本 篤史; 鈴木 智; 岡田 葉平; 木井 雄一郎; 山下 敏彦; 渡邉 耕太
    北海道整形災害外科学会雑誌, 58, 2, 258, 258, 北海道整形災害外科学会, Mar. 2017
    Japanese
  • TKA術前および術後における大腿筋断面積と術後の疼痛・満足度との関係
    赤塚 吉紘; 寺本 篤史; 高島 弘幸; 鈴木 智之; 岡田 葉平; 木井 雄一郎; 今村 塁; 渡邉 耕太; 山下 敏彦
    日本整形外科学会雑誌, 91, 3, S910, S910, (公社)日本整形外科学会, Mar. 2017
    Japanese
  • 特集 次の25年の放射線治療の進歩を見据えて 放射線技術学と日本放射線技術学会の発展に向けて
    高島 弘幸
    臨床放射線, 62, 2, 265, 268, 金原出版, 10 Feb. 2017, [Lead author, Corresponding author]
    Japanese
  • Efficacy of intraoperative direct electrical stimulation of the spinal root and measurement of distal motor latency in lumbar spinal stenosis
    Takao Murohashi; Mitsunori Yoshimoto; Tsuneo Takebayashi; Shuichi Hashimoto; Shouto Yamada; Hiroyuki Takashima; Toshihiko Yamashita
    EUROPEAN SPINE JOURNAL, 26, 2, 434, 440, Feb. 2017, [Peer-reviewed], [International Magazine]
    English, Scientific journal
  • Improvement effect of low back pain with microendoscopic decompression for lumbar spinal stenosis: Comparison with degenerative spondylolisthesis and pattern of neurological disorder
    Ogon Izaya; Takebayashi Tsuneo; Yoshimoto Mitsunori; Takashima Hiroyuki; Morita Tomonori; Terashima Yoshinori; Yamashita Toshihiko
    PAIN RESEARCH, 32, 3, 203, 211, 2017
    Japanese, Scientific journal
  • Magnetic resonance spectroscopic analysis of multifidus muscles lipid content and association with spinopelvic malalignment in chronic low back pain
    Izaya Ogon; Tsuneo Takebayashi; Hiroyuki Takashima; Tomonori Morita; Mitsunori Yoshimoto; Yoshinori Terashima; Toshihiko Yamashita
    BRITISH JOURNAL OF RADIOLOGY, 90, 1073, 20160753, 20160753, 2017, [Peer-reviewed], [International Magazine]
    English, Scientific journal
  • 陳旧性足関節外側靱帯損傷の3D MRI所見
    寺本 篤史; 榊原 醸; 鈴木 智之; 山下 敏彦; 赤塚 吉紘; 高島 弘幸; 渡邉 耕太
    北海道整形災害外科学会雑誌, 58, 1, 138, 138, 北海道整形災害外科学会, Oct. 2016
    Japanese
  • 機能的骨盤座標系から解剖学的骨盤座標系の変換で寛骨臼オリエンテーションはどう変化するのか
    鈴木 大輔; 名越 智; 高島 弘幸; 佐々木 幹人; 岡崎 俊一郎; 加谷 光規; 舘田 健児; 小助川 維摩; 大西 史師; 山下 敏彦
    Hip Joint, 42, 2, 954, 958, 日本股関節学会, Aug. 2016
    Japanese, 日本人の正常股関節120例の骨盤CT画像を3D画像ソフトを用いて三次元構築画像に変換し、3D-CADソフトに取込み計測、座標変化して機能的骨盤肢位(FPP)と解剖学的骨盤肢位(APP)での寛骨臼オリエンテーションを計測した。また、骨盤傾斜角とFPPでの寛骨臼オリエンテーションを用いてAPPでの寛骨臼オリエンテーションの予測式を算出した。その結果、FPPでの寛骨臼オリエンテーションの計測値はAPPでの計測値に比べ、標準偏差および男女差が小さかった。これは解剖学的な寛骨臼オリエンテーションの男女差を、骨盤傾斜の調整により代償していることを示していると考えられた。また、APPの寛骨臼オリエンテーションの予測式は、骨盤傾斜角(FPPでのanterior pelvic planeと冠状面のなす角)とFPPの角度から精度よく求められ、寛骨臼形態の比較に有用であると考えられた。
  • 足関節外側靱帯損傷に対する治療戦略 ストレス撮影は必要である 踵腓靱帯に着目した新たな画像診断ツール3D MRIに加えて
    寺本 篤史; 赤塚 吉紘; 高島 弘幸; 渡邉 耕太; 山下 敏彦
    日本整形外科スポーツ医学会雑誌, 36, 4, 328, 328, (一社)日本整形外科スポーツ医学会, Aug. 2016
    Japanese
  • The signal intensity ratio of the optic nerve to ipsilateral frontal white matter is of value in the diagnosis of acute optic neuritis
    Maki Onodera; Naoya Yama; Masato Hashimoto; Takaharu Shonai; Kazunori Aratani; Hiroyuki Takashima; Ken-ichi Kamo; Hiroshi Nagahama; Hiroshi Ohguro; Masamitsu Hatakenaka
    EUROPEAN RADIOLOGY, 26, 8, 2640, 2645, Aug. 2016, [Peer-reviewed], [International Magazine]
    English, Scientific journal
  • 無線型FPDの線量低減に関する検討 画像特性によるCRとの比較
    次木 嵩人; 早坂 駿; 今村 塁; 赤塚 吉紘; 佐藤 順一; 赤石 泰一; 高島 弘幸; 宍戸 博紀
    北海道放射線技術雑誌, 80, 94, 95, (公社)日本放射線技術学会-北海道支部, Apr. 2016
    Japanese
  • 無線型FPDの線量低減に関する検討 人体ファントムによるCRとの比較
    早坂 駿; 次木 嵩人; 今村 塁; 赤塚 吉紘; 佐藤 順一; 赤石 泰一; 高島 弘幸; 宍戸 博紀
    北海道放射線技術雑誌, 80, 96, 97, (公社)日本放射線技術学会-北海道支部, Apr. 2016
    Japanese
  • balanced SSFPシーケンスを用いた足関節肢位による踵腓靱帯の評価
    赤塚 吉紘; 寺本 篤史; 高島 弘幸; 宍戸 博紀; 今村 塁; 柳田 美香
    北海道放射線技術雑誌, 80, 44, 45, (公社)日本放射線技術学会-北海道支部, Apr. 2016
    Japanese
  • 3D MRIを用いた足関節外側靱帯損傷の経時的評価
    寺本 篤史; 榊原 醸; 鈴木 智之; 山下 敏彦; 赤塚 吉紘; 高島 弘幸; 渡邉 耕太
    北海道整形災害外科学会雑誌, 57, 2, 333, 333, 北海道整形災害外科学会, Apr. 2016
    Japanese
  • Bucket handle損傷型半月に対する関節鏡下縫合術後の治療成績
    久保田 ちひろ; 鈴木 智之; 岡田 葉平; 木井 雄一郎; 寺本 篤史; 渡邉 耕太; 山下 敏彦; 高島 弘幸; 今村 塁; 大坪 英則; 小笠原 一洋; 杉 憲
    北海道整形災害外科学会雑誌, 57, 2, 395, 395, 北海道整形災害外科学会, Apr. 2016
    Japanese
  • 【足関節・足部疾患の最新治療】疾患各論 外傷・スポーツ障害 足関節外側靱帯損傷 3D-MRIを用いた新鮮足関節外側靱帯損傷の評価
    寺本 篤史; 赤塚 吉紘; 高島 弘幸; 鈴木 智之; 渡邉 耕太; 山下 敏彦
    別冊整形外科, 69, 207, 210, (株)南江堂, Apr. 2016
    Japanese, 3D-MRIを用いて正常ボランティア10例の足関節外側靱帯の形態学的計測を行なった。また、あわせて新鮮足関節外側靱帯損傷4例における損傷部位と治療過程の評価を行った。その結果、1)3D-MRIを用いることで正常ボランティアの前距腓靱帯(ATFL)と踵腓靱帯(CFL)は全長にわたって明瞭に描出され、ATFLの幅は平均4.0mm、CFLの幅は平均4.8mmであった。2)靱帯損傷患者のATFLは受傷直後に高信号変化を伴う靱帯途絶所見があり、経時的に高信号を伴うびまん性膨化を示した。ATFLの幅は受傷直後平均5.8mm、4週後は平均7.1mm、8週後は平均8mmであった。3)CFLは1例のみ受傷直後に高信号変化を伴う靱帯途絶所見があり、経時的に高信号を伴うびまん性膨化がみられた。CFLの幅は受傷直後7.2mm、4週後10.9mm、8週後11.5mmであった。尚、CFLに受傷直後の信号変化がなかった3例では、信号や幅は経時的に変化しなかった。以上より、3D-MRIは新鮮足関節外側靱帯損傷の診断と重症度判定、治療過程の評価に有用であることが示唆された。
  • 人工膝関節置換術後の疼痛と術前大腿部筋断面積の関係
    赤塚 吉紘; 寺本 篤史; 高島 弘幸; 鈴木 智之; 岡田 葉平; 木井 雄一郎; 今村 塁; 渡邉 耕太; 山下 敏彦
    日本整形外科学会雑誌, 90, 3, S782, S782, (公社)日本整形外科学会, Mar. 2016
    Japanese
  • 足関節外側靱帯損傷の3D MRI所見と治療選択
    寺本 篤史; 赤塚 吉紘; 高島 弘幸; 榊原 醸; 鈴木 智之; 渡邉 耕太; 山下 敏彦
    日本整形外科学会雑誌, 90, 3, S945, S945, (公社)日本整形外科学会, Mar. 2016
    Japanese
  • Participation/Dispatch Reports on International Conferences in 2016
    Ikeda Shu; Shibukawa Shuhei; Takashima Hiroyuki
    Japanese Journal of Radiological Technology, 72, 8, 708, 710, Japanese Society of Radiological Technology, 2016
    Japanese
  • Evaluation of intramyocellular and extramyocellular lipids in the paraspinal muscle in patients with chronic low back pain using MR spectroscopy: preliminary results
    Hiroyuki Takashima; Tsuneo Takebayashi; Izaya Ogon; Mitsunori Yoshimoto; Yoshinori Terashima; Rui Imamura; Toshihiko Yamashita
    BRITISH JOURNAL OF RADIOLOGY, 89, 1064, 20160136, 20160136, 2016, [Peer-reviewed], [Lead author, Corresponding author], [International Magazine]
    English, Scientific journal
  • MRI of Perfusion: Principles and Clinical Applications.
    Nagahama H; Shonai T; Takashima H; Hirano T; Suzuki J; Sakurai Y
    Igaku butsuri : Nihon Igaku Butsuri Gakkai kikanshi = Japanese journal of medical physics : an official journal of Japan Society of Medical Physics, 36, 2, 103, 109, 2016, [Peer-reviewed], [Domestic magazines]
    Japanese, Scientific journal, The principle and clinical application of measurement of cerebral blood perfusion (CBP) using MRI are described. Purposes of measuring CBP using MRI are wide-ranging. Generally, it is used to diagnose cerebro-vascular disorders or brain tumors. There are two types of measuring methods. One is dynamic susceptibility contrast (DSC) method using a contrast agent as a tracer. Another is an arterial spin labeling (ASL) method using protons in arterial blood as an endogenous tracer, instead of bio-exogenous tracer. Basic theory of ASL method was published in the 1990s, recently, its clinical application has been spreading rapidly by the technological innovations. ASL method is attractive as a way to measure CBP because of its non-invasiveness (no radiation-exposure, not need intravenous injection or blood sampling), and the imaging time is about 5 minutes, thereby the measurement can be repeated. The analysis of DSC method has not been standardized, though various valuable parameters are provided. And the prerequisite of DSC method is uncertain in vivo. On the other hand, the result of ASL is affected by the post labeling delay, and limited to the arterial information.
  • Comparison with magnetic resonance three-dimensional sequence for lumbar nerve root with intervertebral foramen
    Hiroyuki Takashima; Tsuneo Takebayashi; Hiroki Shishido; Mitsunori Yoshimoto; Rui Imamura; Yoshihiro Akatsuka; Yoshinori Terashima; Hiroyoshi Fujiwara; Masateru Nagae; Toshikazu Kubo; Toshihiko Yamashita
    Asian Spine Journal, 10, 1, 59, 64, 2016, [Peer-reviewed], [Lead author, Corresponding author], [International Magazine]
    English, Scientific journal
  • MRI拡散強調像を用いた腰椎椎間板ヘルニアにおける障害神経根の解析
    高島 弘幸; 竹林 庸雄; 吉本 三徳; 寺島 嘉紀; 井田 和功; 今村 塁; 赤塚 吉紘; 山下 敏彦
    北海道整形災害外科学会雑誌, 57, 1, 17, 22, 北海道整形災害外科学会, Dec. 2015, [Lead author, Corresponding author]
    Japanese
  • 無線型FPDの線量低減に関する検討 画像特性によるCRとの比較
    次木 嵩人; 佐藤 順一; 高島 弘幸; 宍戸 博紀; 今村 塁; 赤塚 吉紘; 赤石 泰一
    北海道放射線技術雑誌, 79, 83, 83, (公社)日本放射線技術学会-北海道支部, Oct. 2015
    Japanese
  • 無線型FPDの線量低減に関する検討 人体ファントムによるCRとの比較
    早坂 駿; 佐藤 順一; 高島 弘幸; 宍戸 博紀; 今村 塁; 赤塚 吉紘; 赤石 泰一
    北海道放射線技術雑誌, 79, 83, 83, (公社)日本放射線技術学会-北海道支部, Oct. 2015
    Japanese
  • 3D FIESTA-Cシーケンスを用いた足関節肢位による踵腓靱帯の評価
    赤塚 吉紘; 高島 弘幸; 宍戸 博記; 今村 塁; 柳田 美香; 寺本 篤史
    北海道放射線技術雑誌, 79, 86, 86, (公社)日本放射線技術学会-北海道支部, Oct. 2015
    Japanese
  • Mapping occipital bone thickness using computed tomography for safe screw placement
    Tomonori Morita; Tsuneo Takebayashi; Hiroyuki Takashima; Mitsunori Yoshimoto; Kazunori Ida; Katsumasa Tanimoto; Hirofumi Ohnishi; Hiroyoshi Fujiwara; Masateru Nagae; Toshihiko Yamashita
    JOURNAL OF NEUROSURGERY-SPINE, 23, 2, 254, 258, Aug. 2015, [Peer-reviewed], [International Magazine]
    English, Scientific journal
  • Effect of ankle flexion on the quantification of MRS for intramyocellular lipids of the tibialis anterior and the medial gastrocnemius
    Hiroyuki Takashima; Hiroki Shishido; Rui Imamura; Yoshihiro Akatsuka; Keigo Taniguchi; Mitsuhiro Nakanishi; Junpei Suzuki; Hiroshi Nagahama; Yuki Sakurai; Motomichi Sakata
    Radiological Physics and Technology, 8, 2, 209, 214, 23 Jul. 2015, [Peer-reviewed], [Lead author, Corresponding author], [Domestic magazines]
    English, Scientific journal
  • MRI 3Dシーケンスによる足関節外側靱帯の評価
    赤塚 吉紘; 高島 弘幸; 宍戸 博紀; 今村 塁; 寺本 篤史; 渡邉 耕太; 山下 敏彦
    北海道整形災害外科学会雑誌, 56, 2, 305, 306, 北海道整形災害外科学会, Jul. 2015
    Japanese
  • World Report 国際学会に参加して : RSNA 2014
    高島 弘幸
    JART = 日本診療放射線技師会誌, 62, 6, 551, 553, 日本診療放射線技師会, Jun. 2015
    Japanese
  • Analysis of chronic low back pain with magnetic resonance imaging T2 mapping of lumbar intervertebral disc
    Izaya Ogon; Tsuneo Takebayashi; Hiroyuki Takashima; Katsumasa Tanimoto; Kazunori Ida; Mitsunori Yoshimoto; Hiroyoshi Fujiwara; Toshikazu Kubo; Toshihiko Yamashita
    JOURNAL OF ORTHOPAEDIC SCIENCE, 20, 2, 295, 301, Mar. 2015, [Peer-reviewed], [Domestic magazines]
    English, Scientific journal
  • Visualization of the foramen intervertebral nerve root of cervical spine with 3.0 tesla magnetic resonance imaging: a comparison of three-dimensional acquisition techniques.
    Shishido H; Takashima H; Takebayashi T; Akatsuka Y; Imamura R; Nagahama H; Shirase R
    Nihon Hoshasen Gijutsu Gakkai zasshi, 70, 7, 670, 675, 7, Jul. 2014, [Peer-reviewed], [Domestic magazines]
    Japanese, Scientific journal, Identification of the compression factor in cervical disc herniation and cervical spondylotic radioculopathy is often problematic when using two-dimensional magnetic resonance imaging (MRI). This prompted us to compare and examined three-dimensional sequences, coherent oscillatory state acquisition for the manipulation of image contrast (COSMIC), fast imaging employing steady state acquisition (FIESTA) and T2 star weighted MR angiography (SWAN) with 3.0-Tesla (T) MRI to visualize the foramen intervertebral nerve root for the cervical spine. Fat-suppressed COSMIC (FS-COSMIC) sequence gave the highest signal intensity ratio (1.85 ± 0.06) of the nerve root and vertebral arch. A significant difference in signal intensity ratio of the nerve root was found between FS-COSMIC and FIESTA sequences. No significant difference was found between the FS-COSMIC and FIESTA sequences in the cerebrospinal fluid and the spinal cord. The FS-COSMIC sequence proved to be the most suitable sequence for intra and extra dura matter.
  • Investigation of Intervertebral Disc and Facet Joint in Lumbar Spondylolisthesis using T-2 Mapping
    Hiroyuki Takashima; Tsuneo Takebayashi; Mitsunori Yoshimoto; Yoshinori Terashima; Kazunori Ida; Hiroki Shishido; Rui Imamura; Yoshihiro Akatsuka; Ryuji Shirase; Hiroyoshi Fujiwara; Toshikazu Kubo; Toshihiko Yamashita
    MAGNETIC RESONANCE IN MEDICAL SCIENCES, 13, 4, 261, 266, 2014, [Peer-reviewed], [Lead author], [Domestic magazines]
    English, Scientific journal
  • Subtalar Joint Stress Imaging With Tomosynthesis
    Atsushi Teramoto; Kota Watanabe; Hiroyuki Takashima; Toshihiko Yamashita
    Foot and Ankle Specialist, 7, 3, 181, 183, SAGE Publications Ltd, 2014, [Peer-reviewed], [International Magazine]
    English, Scientific journal
  • [Analysis of diffusion tensor for cervical spinal cord using 3 tesla MRI].
    Takashima H
    Nihon Hoshasen Gijutsu Gakkai zasshi, 69, 11, 1292, 1296, 11, Nov. 2013, [Peer-reviewed], [Lead author, Corresponding author], [Domestic magazines]
    Japanese
  • トモシンセシスによる距骨下関節ストレス撮影
    寺本 篤史; 渡邉 耕太; 小林 拓馬; 山下 敏彦; 高島 弘幸; 赤塚 吉紘
    北海道整形災害外科学会雑誌, 55, 1, 105, 105, 北海道整形災害外科学会, Aug. 2013
    Japanese
  • Efficacy of Diffusion-Weighted Magnetic Resonance Imaging in Diagnosing Spinal Root Disorders in Lumbar Disc Herniation
    Hiroyuki Takashima; Tsuneo Takebayashi; Mitsunori Yoshimoto; Yoshinori Terashima; Kazunori Ida; Toshihiko Yamashita
    SPINE, 38, 16, E998, E1002, Jul. 2013, [Peer-reviewed], [Lead author], [International Magazine]
    English, Scientific journal
  • Differences in Tibiotalar Joint Alignment During Non-loaded and Axial Loaded Condition in Intact Male Feet
    Nozaki Shuhei; Taniguchi Keigo; Takashima Hiroyuki; Watanabe Kota; Hatakenaka Masamitsu; Katayose Masaki
    MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 45, 5, 55, 56, May 2013, [Peer-reviewed]
    English, International conference proceedings
  • [Optimized magnetic resonance sequences and parameters with operative assisted images for radical prostatectomy at 3 tesla-magnetic resonance image].
    Shirase R; Sakurai Y; Nagahama H; Harada K; Takashima H; Nakanishi M; Harada K; Shishido H; Imamura R; Sakata M; Hatakenaka M
    Nihon Hoshasen Gijutsu Gakkai zasshi, 69, 5, 529, 534, 5, May 2013, [Peer-reviewed], [Domestic magazines]
    Japanese, Scientific journal, The objective of our study was to optimize magnetic resonance image (MRI) sequences and parameters using operative assisted images (three-dimensional images) for radical prostatectomy at 3 tesla (T) MRI. Five healthy volunteers underwent MRI on the 3.0 T scanner. Various sequences and parameters [Cube (TE/TR = 18, 50, 90 ms/2000 ms), FIESTA (TE/TR/FA = 2.4 ms/5 ms/40 degrees, 90 degrees), fSPGR (TE/TR/FA = 2.3 ms/11.2 ms/20 degrees), slice thickness = 1.2 mm, matrix = 192 x 160] were respectively compared. Several structures of the pelvis (the central zones and transition zones of the prostate, the peripheral zones of the prostate, seminal vesicles, rectum wall, bladder, muscle and fat) were determined. The signal intensities of these structures were measured on reformatted axial images and compared against several structures of the pelvis. Correlation with various sequences and parameters was based on the signal-to-noise ratio (SNR), the contrast ratio (CR) and the presence of artifacts. Student's t-test was used for statistical analysis. With Cube (TE/TR = 50 ms/2000 ms), the average value of visual evaluation with artifacts was high, and SNR and CR were higher than for other sequence and parameters. Optimized MRI sequences and parameters were Cube (TE/TR = 50 ms/2000 ms) which provides improved SNR and CR and the presence of artifacts with operative assisted images for radical prostatectomy. These operative assisted images obtained from Cube (TE/TR = 50 ms/2000 ms) are likely to be useful for surgery.
  • 人工膝関節大腿骨コンポーネント回旋設置評価におけるトモシンセシスの有用性
    寺本 篤史; 小路 弘晃; 渡邉 耕太; 佐藤 直一; 木井 雄一郎; 工藤 未来; 大坪 英則; 山下 敏彦; 高島 弘幸
    北海道整形災害外科学会雑誌, 54, 2, 322, 322, 北海道整形災害外科学会, Mar. 2013
    Japanese
  • トモシンセシスを用いた遠位脛腓靱帯結合荷重撮影
    寺本 篤史; 渡邉 耕太; 木井 雄一郎; 小林 拓馬; 山下 敏彦; 高島 弘幸
    北海道整形災害外科学会雑誌, 54, 2, 329, 329, 北海道整形災害外科学会, Mar. 2013
    Japanese
  • Correlation between T2 relaxation time and intervertebral disk degeneration
    Hiroyuki Takashima; Tsuneo Takebayashi; Mitsunori Yoshimoto; Yoshinori Terashima; Hajime Tsuda; Kazunori Ida; Toshihiko Yamashita
    SKELETAL RADIOLOGY, 41, 2, 163, 167, Feb. 2012, [Peer-reviewed], [Lead author], [International Magazine]
    English, Scientific journal
  • Vocabulary MRI拡散強調画像
    高島 弘幸
    整形外科, 60, 3, 254, 254, 南江堂, 01 Mar. 2009, [Lead author, Corresponding author]
    Japanese
■ Other Activities and Achievements
■ Books and other publications
■ Lectures, oral presentations, etc.
  • Imaging Analysis Focused on Extending Healthy Life Expectancy
    Hiroyuki Takashima
    Advancing Digital Health & Medical AI, 12 Feb. 2025, Keynote oral presentation
  • 診療放射線技師の未来とダイバーシティ
    高島 弘幸
    2024年度北海道放射線技師会研修会, 09 Nov. 2024
    [Invited]
  • MRI定量的画像解析法による腰痛の可視化
    高島 弘幸
    第32回日本腰痛学会シンポジウム, 26 Oct. 2024
  • 画像で疼痛は可視化できるか？
    高島 弘幸
    Pain Management Hot Topics, 06 Jul. 2023
    [Invited]
  • MR定量的画像解析法による慢性疼痛の病態解明への挑戦
    高島 弘幸
    第109回関西MRI技術研究会, 29 Mar. 2023
    [Invited]
  • 簡単なようで奥が深い腰椎MR検査
    高島 弘幸
    FUJIFILM MRIセミナー in Hokkaido, 25 Feb. 2023
    [Invited]
  • 疼痛の慢性化の病態解明を目指して ～画像からのアプローチ～
    高島 弘幸
    第５回慢性疼痛診療講演会, 10 Jan. 2023
    [Invited]
  • 筋細胞内脂肪は疼痛の慢性化と関連があるか
    高島 弘幸
    Pain Expert Meeting, 09 Nov. 2022
    [Invited]
  • 定量的画像解析法を用いた腰痛評価
    高島 弘幸
    第30回日本腰痛学会シンポジウム, 22 Oct. 2022
  • MRIの研究とその軌跡を振り返る ～北海道から米国への挑戦～
    高島 弘幸
    第90回北海道MRI画像研究会, 10 Dec. 2021
    [Invited]
  • 画像で腰痛は可視化できるのか？ －定量的画像解析法による非特異的腰痛への挑戦－
    高島 弘幸
    第31回腰痛シンポジウム, 27 Feb. 2021
    [Invited]
  • MR造影剤の変遷とその有用性
    高島 弘幸
    ゲルベジャパン, 20 Nov. 2019
    [Invited]
  • 臨床画像研究への橋渡し―臨床に役立つ撮像条件を目指して―
    高島 弘幸
    第2回札幌医科画像研究会, 12 May 2018
  • 腰痛患者におけるMRI定量画像評価法を用いた解析
    高島 弘幸
    第45回脊椎外科懇話会, 02 Mar. 2018
    [Invited]
  • 脊椎・脊髄の構造と機能および撮影法
    高島 弘幸
    第8回オホーツク放射線技師会研修会, 11 Nov. 2017
  • 定量的画像評価法を用いた傍脊柱筋脂肪量と腰痛の解析
    高島 弘幸
    根室学術講演会, 02 Aug. 2017
    [Invited]
  • 慢性腰痛の病態解析－MRIによる定量的評価法による解析－
    高島 弘幸
    脊椎の痛みを学ぶ会in Sapporo 2016, 19 Nov. 2016
    [Invited]
  • 研究と臨床の架け橋 －協会病院から札幌医大へ－
    平成28年度 第13回全道協会病院放射線技師研修会, 21 Oct. 2016
    [Invited]
  • 整形領域の画像検査の考え方とテクニック – 脊椎・脊髄編-
    第19回 札幌テクノロジーフォーラム, 31 Oct. 2014
    [Invited]
  • 整形外科領域のMRI撮像の考え方とテクニック
    高島 弘幸
    平成25年度一般社団法人北海道放射線技師会秋季会員研究発表会（小樽後志）, 16 Nov. 2013
    [Invited]
  • 求ム、整形外科医が望む良質な画像情報
    高島 弘幸
    第19回技術系学術集談会(放射線部門), 29 Sep. 2013
    [Invited]
■ Syllabus
  • 医用画像科学特講, 2024年, 博士後期課程, 保健科学院
  • 医用画像科学特講演習, 2024年, 博士後期課程, 保健科学院
  • 画像検査学Ⅰ, 2024年, 学士課程, 医学部
  • 磁気共鳴学Ⅱ, 2024年, 学士課程, 医学部
  • 磁気共鳴学基礎, 2024年, 学士課程, 医学部
  • 超音波機器工学, 2024年, 学士課程, 医学部
  • 医用機器工学実習, 2024年, 学士課程, 医学部
  • 医療安全管理学, 2024年, 学士課程, 医学部
  • 医療安全管理学, 2024年, 学士課程, 医学部
  • 医療安全管理学Ⅰ, 2024年, 学士課程, 医学部
  • 臨床実習Ⅰ, 2024年, 学士課程, 医学部
  • 臨床実習Ⅱ, 2024年, 学士課程, 医学部
  • 臨床実習Ⅲ, 2024年, 学士課程, 医学部
  • 臨床実習Ⅳ, 2024年, 学士課程, 医学部
  • 臨床実習Ⅴ, 2024年, 学士課程, 医学部
  • 臨床実習Ⅵ, 2024年, 学士課程, 医学部
■ Research Themes
  • ミトコンドリア機能および筋細胞内脂肪に着目した疼痛発生メカニズムの解明
    科学研究費助成事業 基盤研究(C)
    01 Apr. 2023 - 31 Mar. 2028
    高島 弘幸
    日本学術振興会, 基盤研究(C), 北海道大学, 23K08645
  • 中枢性感作が関与する慢性疼痛に対する内臓脂肪と慢性炎症に着目した運動療法の開発
    科学研究費助成事業
    01 Apr. 2024 - 31 Mar. 2027
    黄金 勲矢; 高島 弘幸
    日本学術振興会, 基盤研究(C), 札幌医科大学, 24K14276
  • Investigation of mechanism of pain generation focusing on the relationship between muscle adipose tissue and inflammatory cytokines
    Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists
    01 Apr. 2018 - 31 Mar. 2021
    Takashima Hiroyuki
    Previous studies have reported the relationship between low back pain (LBP) and fat degeneration or atrophy in the paraspinal muscles. We applied MR spectroscopy to the investigation of LBP. We compared intra-myocellular lipid (IMCL) and extra-myocellular lipid (EMCL) in paraspinal muscles between asymptomatic volunteers and LBP patients and reported that IMCL in Mm of patients with LBP was higher than that in Mm of asymptomatic volunteers. However, there were no fundamental studies investigating relationship between IMCL and pain. To investigate the relationship between pain and IMCL, we considered that it was essential to develop animal model indicating increasing IMCL. This study results that there was significant decrease of IMCL using tail-suspended combined with hind-limbs-casted rat model. Tail-suspended combined with casted rat model enables to use as rat model showing decrease of IMCL.
    Japan Society for the Promotion of Science, Grant-in-Aid for Early-Career Scientists, Sapporo Medical University, 18K16667
  • Evaluation of neuromuscular disease activity by diffusion tensor imaging
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
    2010 - 2013
    HATAKENAKA Masamitsu; TAKASHIMA Hiroyuki; TMATSUO Yoshio; OHYAGI Yasumasa; SAKAE Nobutaka; NISHIKAWA Kei; HONDA Hiroshi; SUNAMI Shunya; KAMITANI Takeshi
    The fractional anisotropy of myopathy lesion was decreased by 38%, and lambuda 1, 2, and 3 were increased by 59%, 69%, and 79% compared to normal muscles, respectively. These results suggest that parameters related to diffusion tensor imaging are useful for detecting myopathy lesions. However, when comparing absolute parameter values and setting thresholds, some attentions are needed regarding the MR system characteristics.
    Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), 九州大学->札幌医科大学, Coinvestigator not use grants, Competitive research funding, 22591341