Researcher Database

Hiromi Wada
Graduate School of Humanities and Human Sciences Division of Human Sciences Department of Psychology
Specially Appointed Professor

Researcher Profile and Settings

Affiliation

  • Graduate School of Humanities and Human Sciences Division of Human Sciences Department of Psychology

Job Title

  • Specially Appointed Professor

Degree

  • Ph.D. in Environmental Sciences(Hokkaido University)

URL

J-Global ID

Research Areas

  • Environmental science/Agricultural science / Environmental effects of chemicals

Association Memberships

  • 日本心理学会   日本動物心理学会   日本行動科学学会   北海道心理学会   環境ホルモン学会   Japanese Associates of Behavioral Sciences   

Research Activities

Published Papers

  • Effects of prenatal ethanol exposure on acoustic characteristics of play fighting-induced ultrasonic vocalizations in juvenile rats
    Mohd. Ashik Shahrier, Hiromi Wada
    Neurotoxicology 79 25 - 39 2020/04 [Refereed][Not invited]
  • Effect of decabromodiphenyl ether (BDE-209) on ultrasonic communication in fighting of male adult rats
    Qi Yiming, WADA Hiromi
    Organohalogen Compounds 80 209 - 212 2018 [Refereed][Not invited]
  • Effects of prenatal ethanol exposure on acoustic characteristics of ultrasonic vocalization in rat pups
    Shahrier Mohd. Ashik, WADA Hiromi
    Neurotoxicology 69 29 - 36 2018 [Refereed][Not invited]
  • Effects of decabromodiphenyl ether (BDE-209) on ultrasonic communication in mating behavior of rats
    WADA Hiromi, Qi Yiming
    Organohalogen Compounds 80 602 - 606 2018 [Refereed][Not invited]
  • Hiromi Wada
    NEUROTOXICOLOGY 59 175 - 182 0161-813X 2017/03 [Refereed][Not invited]
     
    Perinatal hypothyroidism causes serious damage to auditory functions that are essential for vocalization development. In rat pups, perinatal hypothyroidism potentially affects the development of ultrasonic vocalization (USV) as a result of hearing deficits. This study examined the effect of perinatal hypothyroidism on the development of USVs in rat pups. Twelve pregnant rats were divided into three groups and treated with the anti-thyroid drug methimazole (MMI) via drinking water, from gestational day 15 to postnatal day (PND) 21. The MMI concentration (w/v) was 0% (control group), 0.01% (low-dose group), or 0.015% (high-dose group). After birth, the pups were individually separated from the dam and littermates on PNDs 5, 10, 15, and 20, and their USVs were recorded for 5 min. On PNDs 5 and 10, compared with the control group, the low- and high-dose groups exhibited reductions of both frequency modulated and downward USVs. On PND 15, however, the low- and high-dose groups displayed increases in number, duration, and amplitude of USVs compared with those in the control group. Lower body weights were observed for the low- and high-dose groups than for the control group. Total thyroxine concentrations in plasma were dose-dependently reduced. The onset of auditory functions appeared on PNDs 11-14. Thus, the rat pups were unable to hear externally produced USVs before PND 11. USVs emitted on PNDs 5 and 10 might have been spontaneous and independent of the pups' own or littermate-emitted USVs. The developmental retardation of vocalization-related organs or muscles might underlie the acoustic alterations of USVs on PNDs 5 and 10. The greater number, duration, and amplitude of USVs on PND 15, after which the hearing onset occurred, suggested that the elevation of auditory thresholds occurred as a result of hearing deficits in the low- and high-dose groups. Perinatal hypothyroidism appears to have caused acoustic alterations in the USV development. (C) 2016 Elsevier B.V. All rights reserved.
  • Decabromodiphenyl ether (BDE-209) and ultrasonic vocalization in rat pups
    WADA Hiromi, Qi Yiming
    Organohalogen Compounds 79 68 - 71 2017 [Refereed][Not invited]
  • Thyroid hormone deficiency and development of ultrasonic vocalization responses in rat pups
    WADA Hiromi
    Organohalogen Compounds 77 324 - 328 2015 [Refereed][Not invited]
  • Hiromi Wada, Shoko Yumoto, Hiroyuki Iso
    NEUROTOXICOLOGY AND TERATOLOGY 37 18 - 22 0892-0362 2013/05 [Refereed][Not invited]
     
    We examined the effect of perinatal hypothyroidism on auditory function in rats using a prepulse inhibition paradigm. Pregnant rats were treated with the antithyroid drug methimazole (1-methyl-2-mercaptoimidazole) from gestational day 15 to postnatal day 21 via drinking water at concentrations (w/v) of 0 (control), 0.002 (low dose), or 0.02% (high dose). Rats from methimazole-treated mothers were tested at ages 1, 6, and 12 months using techniques to examine prepulse inhibition and startle response. The startle stimulus consisted of 40 ms of white noise at 115 dB, whereas the prepulse, which preceded the startle stimulus by 30 ms, consisted of 20 ms of white noise at 75, 85, or 95 dB. When the prepulse intensity was 75 or 85 dB, the high-dose group showed decreased prepulse inhibition percentages compared with the control and low-dose groups. The reduced percentages of prepulse inhibition did not return to control levels over the 12-month study period. In contrast, no differences in prepulse inhibition were observed among the three dose groups when prepulse intensity was 95 dB. Moreover, the high-dose group displayed excessive reaction to auditory startle stimuli compared with the other groups. Reductions in plasma free thyroxine and body weight gain were observed in the high-dose group. We conclude that perinatal hypothyroidism results in irreversible damage to auditory function in rats. (C) 2013 Elsevier Inc. All rights reserved.
  • Masashi Hasegawa, Hiromi Wada
    PHYSIOLOGY & BEHAVIOR 112 90 - 95 0031-9384 2013/03 [Refereed][Not invited]
     
    Thyroid hormones (THs) are essential for proper brain development in mammals. TH insufficiency during early development causes structural and functional abnormalities in brain leading to cognitive dysfunction. The specific effects of developmental hypothyroidism on attention have not been well characterized in animal models. The present study was conducted to characterize the effects of developmental hypothyroidism on attention in rats, and tested the hypothesis that the hypothyroidism has adverse impacts on attention by means of a visual signal detection task. Pregnant rats were exposed to the anti-thyroid drug, methimazole (0.02% w/v) via drinking water from gestational day 15 through postnatal day (PND) 21 to induce maternal and neonatal hypothyroidism. Male offspring served as subjects for the task started on PND 90. A light stimulus (500 ms, 250 ms or 50 ms) was presented in signal trials and not in blank trials. The offspring were required to discriminate these signal events, and subsequently press the correct lever. The correct response for signal and non-signal events was considered as hit and correct rejection, respectively. The hypothyroid offspring exhibited a decreased hit response for short signals (250 ms and 50 ms) which requires the higher attentional demand. The total number of lever responses during inter-trial interval (ITI) was also increased in the hypothyroid group. The number of lever responses was negatively correlated with a hit response at 50 ms, not at 250 ms. These results suggest that developmental hypothyroidism disrupts signal detection performance via impairment of visual attention and the altered lever response behavior. (C) 2013 Elsevier Inc. All rights reserved.
  • Effects of perinatal thyroid hormone deficiency on ultrasonic vocalization in rat pups
    WADA Hiromi
    Organohalogen Compounds 75 610 - 613 2013 [Refereed][Not invited]
  • Effects of perinatal hypothyroidism on shift attention in rats
    Wada, H, Seto Y
    Organohalogen Compounds 74 1385 - 1388 2012 [Refereed][Not invited]
  • 周産期甲状腺ホルモン阻害による認知発達への影響ー注意機能をめぐってー
    和田 博美, 瀬戸 友紀奈
    精神神経学雑誌 114 (8) 949 - 956 2012 [Refereed][Invited]
  • Perinatal hypothyroid rats exhibit long-lasting impairments in spatial learning in the Morris water maze
    WADA Hiromi, SATOH Takuya
    Organohalogen Compounds 73 1476 - 1479 2011 [Refereed][Not invited]
  • Masashi Hasegawa, Ikuhiro Kida, Hiromi Wada
    NEUROSCIENCE LETTERS 479 (3) 240 - 244 0304-3940 2010/08 [Refereed][Not invited]
     
    The thyroid hormone is essential for the proper development of the central nervous system (CNS). Hormone deficiency during CNS development causes neurological abnormalities in the brain. The hippocampus is one of the brain regions vulnerable to hormone deficiency, and the volume of dentate gyrus (DG) and cornu ammonis (CA) are reduced by transient hypothyroidism during CNS development. However, it remains unclear whether transient hypothyroidism specifically reduces the whole hippocampal volume. In the present study, we used magnetic resonance imaging (MRI) to examine the effects of perinatal hypothyroidism on the ratio of hippocampal volume to brain volume as well as brain and hippocampal volumes overall. Perinatal hypothyroidism was induced by adding the anti-thyroid drug, methimazole, to the drinking water of pregnant dams from gestational day 15 to postnatal day 21. The MRI experiment was conducted when the rats were between 7 and 11 months old. The results showed reductions of the hippocampal and brain volume of the treated group. However, the ratio of hippocampal volume to brain volume was comparable between the control and treated groups. These results indicate that perinatal hypothyroidism minimizes the brain as a whole, but does not minimize the hippocampus in particular. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
  • 甲状腺ホルモン阻害ラットの認知行動障害の解析
    長谷川 征史, 米崎 久美子, 湯本 祥子, 和田 博美
    行動科学 48 (2) 165 - 171 2010 [Refereed][Invited]

Books etc

  • 再ーくりかえす世界
    和田 博美 (Joint work甦れ脳細胞! ―運動の効果とニューロジェネシス―)
    北海道大学出版会 2020
  • 発達科学ハンドブック 第8巻 脳の発達科学
    和田 博美 (Contributorアルコールと薬物の影響)
    新曜社,東京 2015
  • A study of healthy being: From interdisciplinary perspectives
    Wai L L, Sakurai Y, Wada H (Joint editorEffects of perinatal hypothyroidism on cognitive and learning behavior: Experimental studies in animals)
    Azusa Syuppan 2010

Conference Activities & Talks

  • Acoustic characteristics of play fighting-induced ultrasonic vocalizations in juvenile rats prenatally exposed to ethanol  [Not invited]
    Shahrier M. A, Wada H
    17th International Neurotoxicology Association  2019/10
  • Acoustic characteristics of ultrasonic vocalizations in rat pups prenatally exposed to ethanol. International Conference on Alcohol and Drugs  [Not invited]
    Shaharier M. A, Wada H
    International Conference on Alcohol and Drugs  2018/10
  • Effects of decabromodiphenyl ether (BDE-209) on ultrasonic communication upon play fighting in juvenile rats  [Not invited]
    Qi Yiming, WADA Hiromi
    17th International Neurotoxicology Association  2018/10
  • Effects of decabromodiphenyl ether (BDE-209) on ultrasonic communication durng fighting of male adult rats  [Not invited]
    Qi Yiming, WADA Hiromi
    Dioxin 2018  2018/08
  • Effects of decabromodiphenyl ether (BDE-209) on ultrasonic communication in mating behavior of rats  [Not invited]
    WADA Hiromi, Qi Yiming
    Dioxin 2018  2018/08
  • 乳仔期ラットの聴覚遮断と超音波発声の発達  [Not invited]
    和田 博美
    日本心理学会  2017/09
  • 乳仔期ラットの聴覚遮断と離乳後の超音波発声  [Not invited]
    和田 博美
    日本動物心理学会  2017/08
  • Decabromodiphenyl ether (BDE-209) and ultrasonic vocalization in rat pups  [Not invited]
    Wada H, Qi I
    Dioxin 2017  2017/08
  • Effects of hearing isolation on the development of ultrasonic vocalization in rat pups  [Not invited]
    Wada H
    Joint Meeting Neurotoxicity Society and International Neurotoxicology Association  2017/05
  • Differential effects of maternal separation periods on anxiety-like behavior in rats  [Not invited]
    Kawamura Y, Wada H
    International Congress of Psychology  2016/07
  • Effects of familiar and unfamiliar olfactory stimuli on ultrasonic vocalization in rat pups  [Not invited]
    Wada H, Shimura M
    International Congress of Psychology  2016/07
  • ラットにおける周産期の甲状腺ホルモン阻害と超音波発声の発達  [Invited]
    和田 博美
    第6回 PCB講演会  2015/12
  • Thyroid hormone deficiency and development of ultrasonic vocalization responses in rat pups  [Not invited]
    WADA Hiromi
    Dioxin 2015  2015/08
  • Perinatal hypothyroidism and ultrasonic vocalization in rat pups  [Not invited]
    Wada H
    International Neurotoxicology Association  2015/06
  • Effects of neonatal maternal-separation on body weights, anxiety-like behavior, and ultrasonic vocalizations in rats  [Not invited]
    Kawamura Y, Wada H
    International Society for Comparative Psychology  2014/09
  • Effects of perinatal thyroid hormone deficiency on selective and sustained attention in rats  [Not invited]
    Wada H, Seto Y
    International Society for Comparative Psychology  2014/09
  • Perinatal thyroid hormone deficiency and ultrasonic vocalization in neonatal and juvenile rats  [Not invited]
    Wada H
    International Child Neurology Congress  2014/05
  • 周産期の甲状腺ホルモン阻害が乳児期ラットの超音波発声に及ぼす影響  [Not invited]
    和田博美
    環境ホルモン学会第16回発表会  2013/12
  • Effects of perinatal thyroid hormone deficiency on ultrasonic vocalization in rat pups  [Not invited]
    Wada H
    Dioxin 2013  2013/08
  • Repeated maternal-separation and ultrasonic vocalization of rat pups  [Not invited]
    Wada H
    International Neurotoxicology Association  2013/06
  • ターゲット検出法の改良による注意能力の多機能試験法の開発と発達神経毒性への応用-選択的注意、持続的注意、移動的注意、及び分割的注意の試験法  [Invited]
    和田博美, 瀬戸友紀奈
    第2回日化協新LRI研究報告会  2013
  • Effects of perinatal hypothyroidism on shift attention in rats  [Not invited]
    Wada H, Seto Y
    Dioxin2012  2012/08
  • Effects of perinatal hypothyroidism on selective and sustained attention in rats  [Not invited]
    WADA Hiromi
    30th International Congress of Psychology  2012/07
  • Effects of perinatal hypothyroidism on divided attention in rats  [Not invited]
    Wada H, Seto Y
    Scientific Committee on Neurotoxicology and Psychophysiology  2012/03
  • ターゲット検出法の改良による選択的注意および持続的注意の試験法開発  [Invited]
    和田博美
    第1回日化協新LRI研究報告会  2012
  • 周産期甲状腺ホルモン阻害による認知発達への影響-注意機能をめぐって  [Invited]
    和田 博美
    日本精神神経学会  2012
  • 周産期甲状腺ホルモン阻害ラットの注意能力―選択的注意と持続的注意―  [Not invited]
    和田 博美
    環境ホルモン学会第14回発表会  2011/12
  • Perinatal hypothyroid rats exhibit long-lasting impairments in spatial learning in the Morris water maze  [Not invited]
    Wada, H, Satoh T
    Dioxin 2011  2011/08
  • Developmental hypothyroidism disrupts performance of a signal detection task in rats  [Not invited]
    Hasegawa, M, Wada, H
    2011 Annual Meeting of the Society of Toxicology  2011/03

MISC

Awards & Honors

  • 2018/10 International Conference on Alcohol and Drugs The Best Presentation Award
     Acoustic characteristics of ultrasonic vocalizations in rat pups prenatally exposed to ethanol 
    受賞者: Shaharier M. A;Wada H

Research Grants & Projects

  • ラットの超音波発声の音響学的変異を利用した生物汚染のモニタリング法
    日本学術振興会:科学研究費補助金
    Date (from‐to) : 2016/04 -2018/03 
    Author : 和田 博美
  • ネズミの超音波コミュニケーションに着目した言語獲得過程の動物モデル構築
    公益財団法人 三菱財団:三菱財団人文科学助成
    Date (from‐to) : 2016/10 -2017/09 
    Author : 和田 博美

Educational Activities

Teaching Experience

  • 博士論文指導特殊演習
    開講年度 : 2019
    課程区分 : 博士後期課程
    開講学部 : 文学研究科
  • 博士論文指導特殊演習Ⅰ
    開講年度 : 2019
    課程区分 : 博士後期課程
    開講学部 : 文学院
  • 修士論文
    開講年度 : 2019
    課程区分 : 修士課程
    開講学部 : 文学研究科
  • 修士論文・特定課題指導特殊演習
    開講年度 : 2019
    課程区分 : 修士課程
    開講学部 : 文学研究科
  • 卒業論文
    開講年度 : 2019
    課程区分 : 学士課程
    開講学部 : 文学部
  • 修士論文・特定課題指導特殊演習
    開講年度 : 2019
    課程区分 : 修士課程
    開講学部 : 文学院

Campus Position History

  • 2013年4月1日 
    2015年3月31日 
    教育改革室室員

Position History

  • 2013年4月1日 
    2015年3月31日 
    教育改革室室員


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