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Last Updated :2024/08/01

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Master

Affiliation (Master)

  • Faculty of Medicine　Center for Medical Education and International Relations

Affiliation (Master)

  • Faculty of Medicine　Center for Medical Education and International Relations

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Profile and Settings

Affiliation

  • Hokkaido University, Faculty of Medicine, Center for Medical Education and International Relations, Professor, 統括副センター長

Profile and Settings

  • Name (Japanese)

    Takahashi

  • Name (Kana)

    Makoto

  • Name

    200901078783288319

Affiliation

  • Hokkaido University, Faculty of Medicine, Center for Medical Education and International Relations, Professor, 統括副センター長

Achievement

Research Interests

  • EPOC   medical education   patient safety   surgical procedure   spinal disorder   

Research Areas

  • Humanities & social sciences / Science education / medical education
  • Life sciences / Orthopedics / spinal surgery
  • Life sciences / Healthcare management, medical sociology / medical education

Research Experience

  • 2019/06 - Today 北海道大学大学院医学研究院 医学教育・国際交流推進センター 統括副センター長
  • 2019/06 - Today Hokkaido Univ Faculty of Medicine Center for Medical Education and International Relations Proffesor
  • 2014/04 - 2019/05 Tokyo Medical and Dental University University Hospital of Medicine
  • 2013/04 - 2019/05 Tokyo Medical and Dental University University Hospital of Medicine
  • 2009/04 - 2019/05 Tokyo Med & Dent Univ Graduate School of Med & Dent sciences Medical Education Research ＆ Development Lecturer
  • 2007/04 - 2009/03 Suwa Central Hospital Orthopaedic surgery Dept Chairperson
  • 2004/04 - 2007/03 Tokyo Med & Dent Univ Graduate School of Med & Dent sciences Orthopaedic surgery Assistant Professor
  • 2003/07 - 2004/03 Tokyo Med & Dent Univ Graduate School of Med & Dent sciences Orthopaedic and Spinal Surgery Assistant Professor
  • 2003/06 - 2003/06 Tokyo Med & Dent Univ Hospital Orthopaedic surgery Fellow
  • 2002/04 - 2003/05 Kudanzaka Hospital Orthopaedic surgery Fellow
  • 2001/04 - 2002/03 Saiseikai Kawaguchi General Hospital Orthopaedic surgery Fellow
  • 1995/01 - 1997/03 Suwa Central Hospital Orthopaedic surgery Resident
  • 1994/07 - 1994/12 Kudanzaka Hospital Orthopaedic surgery Resident
  • 1994/01 - 1994/06 Nakano General Hospital Orthopaedic surgery Resident
  • 1993/07 - 1993/12 Omiya Redcross Hospital Anesthesiology Resident
  • 1992/06 - 1993/06 Tokyo Med & Dent Univ Hospital Orthopaedic surgery Resident

Education

  • 1997/04 - 2001/03  Tokyo Med＆ Dent Univ  Graduate School of Medicine  Department of Orthopaedic Surgery
  • 1986/04 - 1992/03  Tokyo Med＆ Dent Univ  School of Medicine

Awards

  • 2023/07 (一社)日本医学教育学会 Best Young Investigator Award
     Predictors of academic performance among medical students using a cluster-analytic approac 
    受賞者: Goudarzi Houman;Masahiro Onozawa;Yoichi Ito;Makoto Takahashi
  • 2021/07 JSME Internationalization Committee Gold Award
     Impact of COVID-19 on Medical English education: Subjective and objective surveys between 2016 and 2020 
    受賞者: Goudarzi Houman;Takahashi Makoto;Onozawa Masahiro

Published Papers

  • Houman Goudarzi, Masahiro Onozawa, Makoto Takahashi
    BMC medical education 24 (1) 66 - 66 2024/01/17 
    BACKGROUND: Major disruptions and changes in education have occurred worldwide as a result of the coronavirus disease (COVID-19) pandemic and the ensuing shift from in-person to online education. However, the effect of such changes on medical education, its magnitude, and the learning domains impacted by such rapid changes have not been adequately addressed, particularly with regard to objective assessment approaches. METHODS: Second-year medical students enrolled in our Medical English Course between 2019 and 2021 were recruited from Hokkaido University, Japan (N = 321) to participate in this study. We evaluated the potential impact of teaching styles on the academic performance of students before (2019; face-to-face) and during (2020; online; 2021; in-person and online) the pandemic. We examined the potential effect of three teaching styles--in-person (2019), online (2020), and a combination of these (2021) on the academic performance of medical students using: (i) subjective assessment of self-reported general English skills, including reading, writing, listening, and speaking; and (ii) objective assessment of medical terminology scores, evidence-based medicine (EBM) skills, and final written exam scores. RESULTS: In-person education significantly improved listening and speaking skills in 2019 (p < 0.001). This trend was observed for writing skills in an online course in 2020 (p = 0.001). With the combined teaching method, students reported significant improvements in all four English skills. In our objective assessments, medical terminology improved significantly post-test versus pre-test for all three teaching styles, and we found that the online course did not adversely affect the gain in medical terminology knowledge during the course. Additionally, we did not find any significant differences across the three applied teaching styles regarding EBM skill levels. It is noteworthy that the students taking online courses had a significantly higher final exam score (mean ± SD; 82.8 ± 8.2) than in in-person (78.6 ± 8.8) and combined (79.7 ± 12.1) teaching styles. CONCLUSIONS: In our study, the online/combined courses showed better academic outcomes compared to the face-to-face course in the preclinical clerkship. Although the current results need to be replicated on a larger scale, online/combined courses can continue and evolve in the post-pandemic education of medical students. Medical schools and institutions should consider incorporating such courses, especially combined courses, into their curricula in the future to improve the effectiveness, accessibility, and flexibility of medical education.
  • Houman Goudarzi, Masahiro Onozawa, Makoto Takahashi
    Journal of General and Family Medicine 24 (2) 139 - 40 2189-7948 2022/11/07 [Refereed][Not invited]
     
    In 2019 and before the COVID-19 pandemic, about 68% of our medical students in Japan wished to engage in academic activities abroad. However, in 2020 and during the pandemic, this percentage fell to 35%. We found a significant increase in the number of students wishing to go abroad for studies/training in 2021 than in 2020, taking the percentage to the prepandemic level in 2019.
  • Houman Goudarzi, Masahiro Onozawa, Makoto Takahashi
    MedEdPublish 12 15 - 15 2022/06/16 [Refereed]
     

    Background: The aim of this study was to assess the impact of the coronavirus disease 2019 (COVID-19) pandemic on the current study methods and future plans of medical students compared to those in the pre-pandemic period.

    Methods: Second-grade medical students reported their academic experiences, study methods, and future career plans before (between 2016 and 2019) and during the pandemic (2020) using a questionnaire-based survey at Hokkaido University, Japan (n = 534).

    Results: From 2016 to 2019, we found an increasing trend for participation in short-term international exchange programs, taking the United States Medical Licensing Examination (USMLE), clinical training, and undertaking research abroad among the students. However, these percentages significantly declined (to 35.5%) during the COVID-19 pandemic in 2020 for all the assessed future plans, including short-term exchange programs (-27.9%), taking USMLE (-19.8%), clinical training (-24.5%), and undertaking research abroad (-13.2%) compared to 2019, wherein 67.9% of the students wished to have at least one of these four above-mentioned academic activities.

    Conclusions: The COVID-19 pandemic adversely and significantly influenced our medical students’ plans to go abroad for clinical and research training. Future studies are warranted to assess the long-term influence of this pandemic on the career planning of medical students.

  • Manabu Murakami, Kotaro Matoba, Hideki Hyodoh, Makoto Takahashi
    Journal of the Pakistan Medical Association 71 (5) 1 - 6 0030-9982 2021/02/23 [Refereed]
     
    Published in May - 2021
  • Hisashi Shimozono, Nobutoshi Nawa, Makoto Takahashi, Makoto Tomita, Yujiro Tanaka
    MedEdPublish 9 123 - 123 2020/06/18 [Refereed]
     

    This article was migrated. The article was marked as recommended. BackgroundMisdiagnoses are associated with various cognitive biases, which are difficult to reduce even if physicians think about clinical cases deliberately. We propose a new "2-Dimensional Approach" that combines two perspectives in diagnostic reasoning: organs (brain, heart, lung, intestine/liver, kidney) and systems (metabolic, endocrine, blood/tumor, infection, immune, circulatory, nervous systems). Systems involve throughout the whole body and can be pathogenesis of diseases. As a result of diseases, organs show abnormal vital signs and symptoms. We investigated: (1) whether each individual resident has a bias for either organs or systems when they diagnose clinical cases, and (2) whether the 2D Approach can reduce such a bias.MethodsWe randomly assigned PGY1 residents (n=105) to either the 2D Approach group (n=45) or a control group (n=60). After attending either a lecture on the 2D Approach or a non-related lecture, residents were asked to diagnose two clinical cases. We divided each diagnosis into one of the two categories, either "organs" or "systems". We investigated whether each resident would diagnose the two cases into the same category, either organs or systems (i.e., a bias for either organs or systems).ResultsThe participants in the control group tended to diagnose the two cases into the same category, either organs or systems (OR: 5.63, 95% CI: 1.62-21.7, p=0.0030, Fisher's exact test). In the 2D Approach group, the category of diagnoses for the two cases were not related to each other (OR: 2.14, 95% CI: 0.50-9.81, p=0.33).ConclusionThere is a bias for either organs or systems when residents diagnose clinical cases, suggesting that organs and systems are different perspectives in diagnostic reasoning. By combining these 2 different perspectives in a 2-dimensional matrix, the 2D Approach reduces this bias.

  • Hisashi Shimozono, Makoto Takahashi, Makoto Tomita, Kazuki Takada, Yujiro Tanaka
    MedEdPublish 8 134 - 134 2019/06/17 [Refereed]
     

    This article was migrated. The article was marked as recommended. Background: Clinical reasoning is an essential competence of a physician. Particularly, pathophysiological understanding is the key for novices to organize their knowledge and improve clinical reasoning. To this end, we propose a "2-Dimensional (2D) Approach" that visualizes pathophysiology by using a matrix of organs and systems. Methods: This study was a prospective observational study of 100 residents (PGY-1), who attended a lecture on the 2D Approach. They underwent a pre- and post-test that assessed their ability to list differentials for various symptoms and to choose the most likely diagnosis for a case vignette. We stratified the participants according to their baseline knowledge level on the pretest into 2 groups (high-knowledge and low-knowledge). In each of the 2 groups, we compared the change in the pre- and post-test scores between participants who used the 2D Approach during the posttest and those who did not. Results: In the high-knowledge group (n=59), the change in the pre- and post-test scores was significantly larger in the 2D Approach users than non-users (p=0.046), while in the low-knowledge group (n=41), there was no significant difference in the change of the scores between the 2D Approach users and non-users. Conclusions: On condition that residents have sufficient knowledge, the 2D Approach helps them organize their knowledge and improve their clinical reasoning skills, through visualization of pathophysiology on a matrix of organs and systems.

  • 大川淳, 野村徹, 高橋誠
    医療の質・安全学会誌 医療の質・安全学会 7 (3) 235 - 238 1881-3658 2012/09 [Refereed][Not invited]
  • Takashi Hirai, Shigenori Kawabata, Mitsuhiro Enomoto, Tsuyoshi Kato, Shoji Tomizawa, Kenichiro Sakai, Toshitaka Yoshii, Kyohei Sakaki, Makoto Takahashi, Kenichi Shinomiya, Atsushi Okawa
    SPINE 37 (5) 377 - 384 0362-2436 2012/03 [Refereed][Not invited]
     
    Study Design. A retrospective single-center study. Objective. To investigate how functional recovery is influenced by anterior compression of the spinal cord (ACS) and instability at the level of ACS after laminoplasty in patients with cervical spondylotic myelopathy. Summary of Background Data. There have been many reports that patients whose spinal cord cannot be decompressed sufficiently after laminoplasty are likely to show unsatisfactory neurologic outcomes. Notably, postoperative ACS is well known to cause problems. Clinically, however, it remains unknown how functional recovery is inhibited by postoperative ACS. Methods. Sixty-four consecutive patients who underwent expansive laminoplasty for the treatment of myelopathy at our hospital between 1998 and 2005 were reviewed. All 64 patients were available for follow-up. The average follow-up period was 97 months (60-156 months). Patients were divided into 2 groups: the ACS(+) group comprised 16 patients who had ACS 3 years postoperatively, and the ACS(-) group comprised 48 patients with no ACS. Clinical outcome was compared in terms of the Japanese Orthopaedic Association score ( mean total score, mean score of each item, and recovery rates). Results. Demographics were similar between the 2 groups. Mean Japanese Orthopaedic Association score at final follow-up was 12.1 points (recovery rate 34.0%) in the ACS(+) group and 13.8 points (recovery rate 56.6%) in the ACS(-) group, and there was a significant difference in recovery rate between the groups (P < 0.05). Notably, a significant difference was found between the 2 groups in improvement of upper extremity motor function (P < 0.05). In addition, we found that not only the presence of ACS but also postoperative hypermobility of the intervertebral segment with ACS influenced clinical outcome negatively. Conclusion. These results demonstrate that ACS after laminoplasty could be a risk factor for clinical outcome and might prevent improvement in upper extremity motor function in patients with myelopathy.
  • Kenichiro Sakai, Atsushi Okawa, Makoto Takahashi, Yoshiyasu Arai, Shigenori Kawabata, Mitsuhiro Enomoto, Tsuyoshi Kato, Takashi Hirai, Kenichi Shinomiya
    SPINE 37 (5) 367 - 376 0362-2436 2012/03 [Refereed][Not invited]
     
    Study Design. Prospective, comparative clinical study. Objective. To compare the clinical outcome of anterior decompression and fusion with floating method and laminoplasty in the treatment of cervical myelopathy caused by ossification of the posterior longitudinal ligament (OPLL). Summary of Background Data. There have been no reports that have accurately and prospectively compared surgical outcomes after anterior decompression and posterior decompression. Methods. For cervical myelopathy caused by OPLL, we performed anterior decompression and fusion with floating method (ADF) in 1997, 1999, 2001, 2003, and 2004 and French-door laminoplasty (LAMP) in 1996, 1998, 2000, and 2002 at one institution. Twenty patients in the ADF group and 22 patients in the LAMP group were evaluated for 5 years' follow-up. The following criteria were evaluated: operation time, blood loss, complications, and Japanese Orthopedic Association score. For radiographic evaluation, canal narrowing ratio of OPLL, lordotic angle at C2-C7, and postoperative progression of the ossified lesion were measured. Results. The operation time in the ADF group was longer than that in the LAMP group. The average blood loss showed no statistical difference between the 2 groups. Complications occurred in 5 cases in the ADF group, but none occurred in the LAMP group. The mean Japanese Orthopedic Association score system for cervical myelopathy and the recovery rate in the ADF group were superior to those in the LAMP group, especially for cases with greater than 50% of the spinal canal compromised by OPLL or kyphotic alignment of the cervical spine, preoperatively. Postoperative progression of OPLL was observed in 5% of the ADF group and 50% of the LAMP group. Conclusion. ADF is considered especially suitable for cases with massive OPLL and preoperative kyphotic alignment of the cervical spine, although it leads to a higher incidence of surgery-related complications compared with LAMP.
  • Takashi Hirai, Atsushi Okawa, Yoshiyasu Arai, Makoto Takahashi, Shigenori Kawabata, Tsuyoshi Kato, Mitsuhiro Enomoto, Shoji Tomizawa, Kenichiro Sakai, Ichiro Torigoe, Kenichi Shinomiya
    SPINE 36 (23) 1940 - 1947 0362-2436 2011/11 [Refereed][Not invited]
     
    Study Design. A clinical prospective study. Objective. To assess whether clinical and radiologic outcomes differ between anterior decompression and fusion (ADF) and laminoplasty (LAMP) in the treatment of cervical spondylotic myelopathy (CSM). Summary of Background Data. No reports to date have accurately and prospectively compared middle-term clinical outcomes after anterior and posterior decompression for CSM. Methods. We prospectively performed LAMP (n = 50) in 1996, 1998, 2000, and 2002, and ADF (n = 45) in 1997, 1999, 2001, and 2003. The Japanese Orthopedic Association (JOA) score, recovery rate, and each item of the JOA score were evaluated. For radiographic evaluation, the lordotic angle and range of motion (ROM) at C2-C7 and residual anterior compression to the spinal cord (ACS) after LAMP on magnetic resonance imaging were investigated. Results. Eighty-six patients (ADF n = 39; LAMP n = 47) could be followed for more than 5 years (follow-up rate 91.5%). Demographics were similar between the two groups. The mean JOA score and recovery rate in the ADF group were superior to those in the LAMP group from 2-year data collected after surgery. However, LAMP was safer and less invasive than ADF with respect to physical status and complications in the perioperative period. For individual items of the JOA score, the ADF group showed significantly more improvement of upper extremity motor function than the LAMP group (P < 0.05). There was a significant difference in maintenance of the lordotic angle in the ADF group compared with the LAMP group despite no difference in ROM. The LAMP group was divided into two subgroups: (1) LAMP(+) (n = 16) comprising patients who had ACS at 2 years after surgery, and (2) LAMP(-) (n = 31) comprising patients without ACS. Recovery rate differed significantly between the LAMP(+) and LAMP(-) groups despite there being no difference between the LAMP(-) and ADF groups. Conclusion. The recovery rate of the JOA score in the ADF group was better than that in the LAMP group. The clinical outcomes after LAMP could be influenced by ACS.
  • Atsushi Okawa, Kenichiro Sakai, Takashi Hirai, Tsuyoshi Kato, Shoji Tomizawa, Mitsuhiro Enomoto, Shigenori Kawabata, Makoto Takahashi, Kenichi Shinomiya
    SPINE 36 (9) E582 - E587 0362-2436 2011/04 [Refereed][Not invited]
     
    Study Design. Retrospective case series. Objective. To investigate risk factors for early reconstruction failure of multilevel cervical corpectomy with dynamic plate fixation. Summary of Background Data. For anterior cervical decompression and fusion, reinforcement by plate fixation was performed to decrease early reconstruction failure and to increase the fusion rate. However, a relatively high complication rate such as graft dislodgement, has been reported in patients undergoing multilevel corpectomy and reconstruction. Risk factors associated with early reconstruction failure have not been explicitly described. Methods. In 30 instrumented multilevel corpectomy and reconstruction, medical records and radiographic studies were reviewed to investigate risk factors with regard to sagittal alignment of the cervical spine, graft subsidence, screws used in fixation, endplate preparation, and intermediate screw for fibular graft. Results. Reconstruction failures included anterior slipping at the bottom of the graft in 2 cases, fracture of the C7 vertebral body in 2 cases, and pullout of a screw in 2 cases. Four patients were found to have nonunion of the graft at the final follow-up, but none had experienced early reconstruction failure. On radiologic measurement, the fusion area lordotic angle after surgery in the patients with reconstruction failures was significantly larger than that of the patients with no complications. The postoperative C2-C7 lordotic angles of the patients with reconstruction failure were also larger, but this trend was not statistically significant. No other factor, such as age and gender, type of screw used, intermediate screw or preservation of the endplates was related to reconstruction failures in this study. Conclusion. Postoperative cervical hyperlordosis may adversely affect graft stability in the early postoperative period of the surgery of corpectomy and reconstruction with dynamic plate fixation.
  • SASAKI Shinichi, TAKAHASHI Makoto, OKAWA Atsushi, SHINOMIYA Kenichi
    東日本整災会誌 23 (1) 137 - 141 1342-7784 2011/03 [Refereed][Not invited]
  • TAKAHASHI Makoto, OKAWA Atsushi, YAMAWAKI Masanaga, MOMOHARA Yoshihito, OHOKA Shinya, TANAKA Yujiro
    医学教育 日本医学教育学会 42 (1) 19 - 23 0386-9644 2011/02 [Refereed][Not invited]
  • 志村治彦, 太田剛, 松山嘉彦, 高橋誠, 白澤進一, 若林良明
    東日本整形災害外科学会雑誌 21 (1) 125 - 128 1342-7784 2009/03 [Refereed][Not invited]
  • Okawa A, Sakai K, Hirai T, Kato T, Tomizawa S, Kawabata S, Takahashi M, Shinomiya K
    Journal of the Japanese Society for Spine Surgery and Related Research 20 (3) 761 - 765 1346-4876 2009 [Refereed][Not invited]
  • 松本守雄, 千葉一裕, 戸山芳昭, 竹下克志, 星地亜都司, 中村耕三, 有水淳, 藤林俊介, 平林茂, 平野徹, 岩崎幹季, 金岡恒治, 川口善治, 井尻幸成, 前田健, 松山幸弘, 三上靖夫, 村上英樹, 永島英樹, 永田見生, 中原進之介, 野原裕, 岡史朗, 阪本桂造, 猿橋康雄, 笹生豊, 清水克時, 田口敏彦, 高橋誠, 田中靖久, 谷俊一, 徳橋泰明, 内田研造, 山本謙吾, 山崎正志, 横山徹, 吉田宗人, 西脇祐司
    臨床整形外科 43 (6) 531 - 538 2008/06 [Not refereed][Invited]
  • 若手整形外科医は何を考えているか 臨床と研究の両立について 基礎研究に従事する大学院生の現況 基礎と臨床のはざまで
    吉井俊貴, 鳥越一郎, 二村昭元, 早乙女進一, 高橋誠, 若林良明, 四宮謙一
    日本整形外科学会雑誌 82 (5) 408 - 416 2008/05 [Not refereed][Invited]
  • Morio Matsumoto, Kazuhiro Chiba, Yoshiaki Toyama, Katsushi Takeshita, Atsushi Seichi, Kozo Nakamura, Jun Arimizu, Shunsuke Fujibayashi, Shigeru Hirabayashi, Toru Hirano, Motoki Iwasaki, Kouji Kaneoka, Yoshiharu Kawaguchi, Kosei Ijiri, Takeshi Maeda, Yukihiro Matsuyama, Yasuo Mikami, Hideki Murakami, Hideki Nagashima, Kensei Nagata, Shinnosuke Nakahara, Yutaka Nohara, Shiro Oka, Keizo Sakamoto, Yasuo Saruhashi, Yutaka Sasao, Katsuji Shimizu, Toshihiko Taguchi, Makoto Takahashi, Yasuhisa Tanaka, Toshikazu Tani, Yasuaki Tokuhashi, Kenzo Uchida, Kengo Yamamoto, Masashi Yamazaki, Toru Yokoyama, Munehito Yoshida, Yuji Nishiwaki
    SPINE 33 (9) 1034 - 1041 0362-2436 2008/04 [Refereed][Not invited]
     
    Study Design. Retrospective multi-institutional study Objective. To describe the surgical outcomes in patients with ossification of the posterior longitudinal ligament in the thoracic spine (T-OPLL) and to clarify factors related to the surgical outcomes. Summary of Background Data. Detailed analyses of surgical outcomes of T-OPLL have been difficult because of the rarity of this disease. Methods. The subjects were 154 patients with T-OPLL who were surgically treated at 34 institutions between 1998 and 2002. The surgical procedures were laminectomy in 36, laminoplasty in 51, anterior decompression via anterior approach in 25 and via posterior approach in 29, combined anterior and posterior fusion in 8, and sternum splitting approach in 5 patients. Instrumentation was conducted in 52 patients. Assessments were made on (1) The Japanese Orthopedic Association (JOA) scores (full score, 11 points), its recovery rates, (2) factors related to surgical results, and (3) complications and their consequences. Results. (1) The mean JOA score before surgery was 4.6 +/- 2.0 and, 7.1 +/- 2.5 after surgery. The mean recovery rate was 36.8% +/- 47.4%. (2) The recovery rate was 50% or higher in 72 patients (46.8%). Factors significantly related to this were location of the maximum ossification (T1-T4) (odds ratio, 2.43-4.17) and the use of instrumentation (odds ratio, 3.37). (3) The frequent complications were deterioration of myelopathy immediately after surgery in 18 (11.7%) and dural injury in 34 (22.1%) patients. Conclusion. The factors significantly associated with favorable surgical results were maximum ossification located at the upper thoracic spine and use of instrumentation. T-OPLL at the nonkyphotic upper thoracic spine can be treated by laminoplasty that is relatively a safe surgical procedure for neural elements. The use of instrumentation allows correction of kyphosis or prevention of progression of kyphosis, thereby, enhancing and maintaining decompression effect, and its use should be considered with posterior decompression.
  • Kazuyuki Fukushima, Mitsuhiro Enomoto, Shoji Tomizawa, Makoto Takahashi, Yoshiaki Wakabayashi, Soichiro Itoh, Yoshinori Kuboki, Kenichi Shinomiya
    Journal of Medical and Dental Sciences 55 (1) 71 - 79 1342-8810 2008/03 [Refereed][Not invited]
     
    We developed a honeycomb-shaped lyophilized Type I atelocollagen (Honeycomb Collagen: HC) with different pore sizes, and the effectiveness of the honeycomb shape on nerve regeneration was examined. We analyzed neurite outgrowth of dorsal root ganglion (DRG) explants on HC, both in vitro and, with direct implantation of HC into the defects of adult rat spinal cords, in vivo. The neu-rites of DRGs on HC extended linearly through the pores. HC with a 400 μm-pore size enhanced neurite extension, and YIGSR laminin peptide coating to the HC extended more neurites than fibronectin coating. The HC scaffolds coated with YIGSR were implanted into 2 mm-defects of spinal cords at the level of T8-9. Four weeks after implantation, the implants had degraded and been replaced with self-tissues, repairing the injured site. Neurofilament-positive fibers were observed in the implantation area and passed the borders between the HC and spinal cord stumps. Functionally, a motor-evoked potential was observed in the quadriceps femoris muscle 10 weeks after implantation. The electrophysiological examination showed reconstruction of axon tracts over the implant. This result indicates that our developed honeycomb shape is advantageous for host spinal cord compared to the random pored sponge shape, and that it promotes axonal regeneration after spinal cord injury.
  • 脊髄誘発磁界を用いた脊髄不完全損傷の診断
    友利正樹, 川端茂徳, 新井嘉容, 高橋誠, 加藤剛, 富澤將司, 四宮謙一
    脊髄機能診断学 29 (1) 47 - 52 2008/02 [Refereed][Not invited]
  • 頸髄症手術症例の予後診断における術前脊髄誘発電位の有用性の検討
    友利正樹, 川端茂徳, 新井嘉容, 高橋誠, 加藤剛, 富澤將司, 四宮謙一
    脊髄機能診断学 29 (1) 53 - 57 2008/02 [Refereed][Not invited]
  • Randomized clinical trial (RCT) for lumbar degenerative spondylolisthesis surgery
    Kato T, Okawa A, Arai Y, Takahashi M, Kawabata S, Sakai K, Tomizawa S, Tomori M, Mizuno K, Haro H, Shinomiya K
    Journal of the Japanese Society for Spine Surgery and Related Research 19 (3) 625 - 629 2008 [Refereed][Invited]
  • 脊椎内視鏡下手術の現状 2006年1月～12月手術施行状況調査・インシデント報告集計結果
    長谷川徹, 相澤俊峰, 猪川輪哉, 伊東学, 江原宗平, 岡治道, 加藤真介, 加藤圭彦, 川上守, 川原範夫, 古賀公明, 紺野慎一, 坂本直俊, 佐藤公治, 佐藤公昭, 高野裕一, 高橋誠, 田中雅人, 出沢明, 中野恵介, 中村博亮, 夏山元伸, 長谷川和宏, 蜂谷裕道, 平泉裕, 藤本吉範, 前川慎吾, 前田健, 松本守雄, 三上靖夫, 望月眞人, 八木省次, 山縣正庸, 山元拓哉, 湯澤洋平, 吉田宗人, 四宮謙一, 戸山芳昭, 日本整形外科学会脊椎内視鏡下手術, 技術認定制度委員会脊椎内視鏡下手術インシデントワーキンググループ
    日本整形外科学会雑誌 81 (12) 1072 - 1077 2007/12 [Not refereed][Invited]
  • 【頸椎症性脊髄症治療の進歩】 頸椎症性脊髄症の手術療法 前方除圧固定と椎弓形成術の治療成績の比較
    佐々木真一, 四宮謙一, 大川淳, 新井嘉容, 高橋誠, 川端茂徳
    整形・災害外科 50 (9) 965 - 970 2007/08 [Not refereed][Invited]
  • 術中脊髄モニタリングにより神経障害を回避し得たと思われる症例について
    富澤將司, 川端茂徳, 小森博達, 大川淳, 新井嘉容, 高橋誠, 大久保治修, 佐々木真一, 星野優子, 四宮謙一
    脊髄機能診断学 28 (1) 117 - 123 2007/01 [Refereed][Not invited]
  • Ichiro Torigoe, Shinichi Sotome, Akio Tsuchiya, Toshitaka Yoshii, Makoto Takahashi, Shigenori Kawabata, Kenichi Shinomiya
    CELL TRANSPLANTATION 16 (7) 729 - 739 0963-6897 2007 [Refereed][Not invited]
     
    The efficient seeding of cells into porous scaffolds is important in bone tissue engineering techniques. To enhance efficiency, we modified the previously reported cell seeding techniques using low-pressure conditions. In this study, the effects of low pressure on bone marrow-derived stromal cells (BMSCs) of rats and the usefulness of the modified technique were assessed. There was no significant difference found in the proliferative and osteogenic capabilities among various low-pressure (50-760 mmHg, 1-10 min) conditions. To analyze the efficacies of the cell seeding techniques, BMSCs suspended in the plasma of rats were seeded into porous beta-tricalcium phosphate (beta-TCP) blocks by the following three procedures: 1) spontaneous penetration of cell suspension under atmospheric pressure (SP); 2) spontaneous penetration and subsequent low pressure treatment (SPSL), the conventional technique; and 3) spontaneous penetration under low pressure conditions (SPUL), the modified technique. Subsequently, these BMSCs/beta-TCP composites were used for the analysis of cell seeding efficiency or in vivo bone formation capability. Both the number of BMSCs seeded into beta-TCP blocks and the amount of bone formation of the SPUL group were significantly higher than those of the other groups. The SPUL method with a simple technique permits high cell seeding efficiency and is useful for bone tissue engineering using BMSCs and porous scaffolds.
  • 内視鏡下腰椎椎間板ヘルニア摘出術(MED)の問題点とその対策
    新井嘉容, 高橋誠, 北原建彰, 江幡重人, 佐藤浩一, 四宮謙一
    東日本整形災害外科学会雑誌 18 (4) 484 - 488 2006/12 [Refereed][Not invited]
  • 日本の内視鏡下手術技術認定制度と脊椎内視鏡下手術の現状
    長谷川徹, 相澤俊峰, 猪川輪哉, 伊東学, 江原宗平, 岡治道, 加藤真介, 加藤圭彦, 川上守, 川原範夫, 古賀公明, 紺野慎一, 坂本直俊, 佐藤公治, 佐藤公昭, 高野裕一, 高橋誠, 田中雅人, 出沢明, 中野恵介, 中村博亮, 夏山元伸, 長谷川和宏, 蜂谷裕道, 平泉裕, 藤本吉範, 前川慎吾, 前田健, 松本守雄, 三上靖夫, 望月眞人, 八木省次, 山縣正庸, 山元拓哉, 湯澤洋平, 吉田宗人, 四宮謙一, 戸山芳昭, 日本整形外科学会脊椎内視鏡下手術, 技術認定制度委員会
    日本整形外科学会雑誌 80 (10) 754 - 761 2006/10 [Not refereed][Invited]
  • Taizo Horikoshi, Koichi Maeda, Yoshiharu Kawaguchi, Kazuhiro Chiba, Kanji Mori, Yu Koshizuka, Shigeru Hirabayashi, Kazuhito Sugimori, Morio Matsumoto, Hiroshi Kawaguchi, Makoto Takahashi, Hisashi Inoue, Tomoatsu Kimura, Yoshitaka Matsusue, Itsuro Inoue, Hisatoshi Baba, Kozo Nakamura, Shiro Ikegawa
    HUMAN GENETICS 119 (6) 611 - 616 0340-6717 2006/07 [Refereed][Not invited]
     
    Research to date has identified several genes that are implicated in the etiology of ossification of the posterior longitudinal ligament of the spine (OPLL); however, their pathogenetic relevance remains obscure. The aim of this study is to identify susceptibility genes for OPLL through a large-scale case-control association study and to re-examine previously reported associations. A total of 109 single nucleotide polymorphisms (SNPs) in 35 candidate genes were genotyped for 711 sporadic OPLL patients and 896 controls. The differences in allelic and genotypic distribution between patients and controls were assessed using the chi(2) test with Bonferroni's correction. We also analyzed the association by separating patients into subgroups according to sex, age and the number of ossified vertebrae. The nominal P values fell below 0.05 for five SNPs in three genes. An intronic SNP in the TGF3 gene (P=0.00040) showed the most significant association. Previously reported associations of COL11A2, NPPS and TGFB1 with OPLL could not be reproduced. Further, no significant associations were detected in stratified analyses based on sex, age or the number of ossified vertebrae. TGFB3 warrants further investigation because it is located within a genomic region that has been positively linked with OPLL.
  • Sasaki S, Shinomiya K, Okawa A, Arai Y, Takahashi M, Kawabata S, Orii H, Tomizawa S
    Journal of the Japanese Society for Spine Surgery and Related Research 17 (3) 841 - 845 1346-4876 2006 [Refereed][Invited]
  • Takahashi M, Arai Y, Kawabata S, Sasaki S, Okawa A, Shinomiya K
    Journal of the Japanese Society for Spine Surgery and Related Research 17 (3) 870 - 872 1346-4876 2006 [Refereed][Invited]
  • SATO Tetsuya, YOSHIDA Hirotoshi, KITAHARA Kensyou, EBATA Shigeto, TAKAHASHI Makoto, SATO Hirokazu
    関東整形災害外科学会雑誌 36 (3) 99 - 103 0389-7087 2005/06 [Refereed][Not invited]
  • 若杉琢磨, 高橋誠, 榎本光裕, 大川淳, 小森博達, 四宮謙一
    骨・関節・靱帯 17 (10) 1151 - 1155 0915-1125 2004/10 [Refereed][Not invited]
  • 原憲司, 中井修, 進藤重雄, 水野広一, 大谷和之, 高橋誠, 草野和生, 三宅論彦, 山浦伊裟吉
    臨床整形外科 医学書院 39 (1) 49 - 54 0557-0433 2004 [Refereed][Not invited]
  • Jun Ye, Hirotaka Haro, Makoto Takahashi, Hiroshi Kuroda, Kenichi Shinomiya
    Journal of Orthopaedic Science 8 (3) 387 - 395 0949-2658 2003 [Refereed][Not invited]
     
    We investigated cellular and matrix responses of articular cartilage to heat shock. Rat articular cartilage was pretreated at 37°C for 24 h before being exposed to 48°C for 10 min and subsequently incubated at 37°C for 1, 2, 4, 7, 10, and 14 days. Following heat shock, a terminal deoxynucleotidyl transferase nick end labeling assay showed that articular chondrocyte apoptosis appeared at day 1, peaked at day 7, and declined by day 14. Analysis by transmission electron microscopy confirmed that the chondrocytes had characteristic morphological features of apoptosis immunohistochemical staining revealed that caspase-3 activity in chondrocytes increased, 3-B-3-positive articular chondrocytes decreased in number, and the expression of 3-B-3 native epitope in articular chondrocytes was reduced. Safranin-O staining revealed that depletion of proteoglycans in the matrix was not found in any group. Morphological and biochemical evidence from this study suggested that heat shock at 48°C induced articular chondrocyte apoptosis and suppressed proteoglycan synthesis of articular cartilage in vitro. This study thus provides evidence of the onset of osteoarthritis induced by heat shock and a basis for choosing a temperature at which malignant bone tumor cells can be killed with minimal damage to articular cartilage.
  • Y Wakabayashi, H Komori, T Kawa-Uchi, K Mochida, M Takahashi, ML Qi, K Otake, K Shinomiya
    SPINE 26 (11) 1215 - 1222 0362-2436 2001/06 [Refereed][Not invited]
     
    Study Design. The functional recovery of rats that underwent spinal cord transection in infancy was evaluated by multimodal examination (functional rests, electrophysiologic evaluation, tract-tracing) to determine the basis for the recovery. Objectives. To determine whether the hind limb function in rats that underwent spinal cord transection in infancy is regained completely, which descending tracts regenerate after the transection, and whether the functional recovery is correlated with axonal reconnection. Summary of Background Data. It is widely accepted that a newborn rat recovers its hind limb function after spinal cord transection even without any specific treatments. This functional recovery might be attributed to possible regeneration of some descending pathways, although there is a counterargument that well-trained spinal cord reflexes may bring about functional compensation. Methods. The thoracic spinal cord of infant rats was completely transected at Thin when they were 2 weeks of age. Multimodal functional tests and electrophysiologic studies were performed 5 weeks later. Some recovered rats (i.e., those able to walk after the transection) underwent spinal cord retransection, with subsequent reevaluation of locomotion and muscle-evoked potentials. At 6 weeks after the initial transection, tract-tracing studies were performed in some animals. Results. A motor performance score detected the functional differences between the control and the recovered rats. Muscle-evoked potentials of hind limbs after electrical stimulation to the brain were recorded in some of the recovered rats, but never in the unrecovered rats. Moreover, the muscle-evoked potentials of the recovered rats disappeared after spinal cord retransection that resulted in loss of voluntary movement. Morphologic studies in two rats provided evidence that reconnection of rubrospinal, vestibulospinal, and reticulospinal tracts had occurred, whereas corticospinal regeneration was not detected. Conclusions. It can be concluded that the hind limb function of rats that underwent spinal cord transection in infancy was partially regained; that axonal regeneration of the rubrospinal, vestibulospinal, or reticulospinal tracts was demonstrated, whereas the reconnection of the corticospinal tract was not observed; and that the axonal regeneration of these tracts is involved in the functional recovery.
  • M Takahashi, H Haro, Y Wakabayashi, T Kawa-uchi, H Komori, K Shinomiya
    JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME 83B (4) 491 - 495 0301-620X 2001/05 [Refereed][Not invited]
     
    It has been suggested that matrix metalloproteinase-3 (MMP-3, stromelysin-1) has an important role in the degeneration of intervertebral discs (IVDs), A human MMP-3 promoter 5A/6A polymorphism was reported to be involved in the regulation of MMP-3 gene expression. We suggest that IVD degeneration is associated with 5A/6A polymorphism. We studied 54 young and 49 elderly Japanese subjects. Degeneration of the lumbar discs was graded using MRI in the younger group and by radiography in the elderly. 5A/6A polymorphism was determined by polymerase-chain reaction-based assays. We found that the 5A5A and 5A6A genotype in the elderly was associated with a significantly larger number of degenerative IVDs than the 6A6A (p < 0.05), but there was no significant difference in the young. In the elderly, the IVD degenerative scores were also distributed more highly in the 5A5A and 5A6A genotypes (p = 0.0029). Our findings indicate that the 5A allele is a possible risk factor for the acceleration of degenerative changes in the lumbar disc in the elderly.
  • 四肢短縮型小人症における脊柱靱帯骨化症の解析
    河内敏行, 高橋誠, 小森博達, 四宮謙一
    厚生省特定疾患対策研究11年度研究報告書 脊柱靱帯骨化症に関する調査研究 58 - 60 2000 [Not refereed][Not invited]
  • H Nakaguchi, T Fujimaki, K Ueki, M Takahashi, H Yoshida, T Kirino
    JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE 46 (6) 1066 - 1069 1079-6061 1999/06 [Refereed][Not invited]
     
    Background: The popularity of snowboarding has been growing rapidly throughout the world. To date, however, the risk of head injury associated with this relatively new winter sport, especially in comparison with alpine skiing, has not been well analyzed, This study was conducted to assess the risk of head injury in snowboarding and to elucidate its features in comparison with skiing head injury. Methods: We prospectively analyzed 301 cases of head injuries related to snowboarding or skiing experienced from December of 1995 to May of 1997 at our institution, which is located close to the most popular skiing areas in Japan. Of those injuries, 143 cases were snowboard related and 158 cases were ski related. In addition to appropriate medical evaluation and medical care, detailed examination was performed on every patient to determine various factors, including ses, age, skill level, cause and mechanism of the accident, and the side of impact to the head. The data are statistically analyzed to elucidate unique features of snowboard head injury. Results: During the study period, 2.2 million snowboarders and 4.2 million skiers visited the five skiing facilities that are covered hg our hospital. Thus, the incidence of head injury was 6.5 per 100,000, visits for snowboarders and 3.8 per 100,000 visits for skiers. Beginning snowboarders more frequently sustained head injuries compared with beginning skiers (60 of 142 vs. 48 of 154, p = 0.022), Likewise, frequent causes of snowboarding head injuries were fall during jumping (43 of 139 vs. 2 of 147, p < 0.0001), falling backward (67 of 127 vs. 49 of 147, p = 0.001)! and occipital impact (67 of 126 vs, 49 Of 147).,More importantly, there were nine major head injury cases (6.3%) in snowboard head injuries in contrast to only two such cases found in skiing head injuries (1.3%). Of II major head injury cases, 10 were caused by occipital impact. Conclusion: These results indicate that snowboarders sl particularly beginners, are at higher risk for head injury, frequently involving occipital impact, and could lead to more major head injuries. We propose that measures should be taken to protect the head, especially the occiput, in snowboarding.
  • 渡邊 敏文, 吉田 裕俊, 江黒 日出男, 肱黒 泰志, 後藤 敏, 高橋 誠
    臨床整形外科 (株)医学書院 34 (2) 177 - 184 0557-0433 1999/02 [Refereed][Not invited]
     
    過去2シーズンに扱ったスノーボード外傷547例を,スキー外傷742例と比較検討した.スノーボード外傷患者は20歳代に集中し79%(スキー35%)を占めており,初心者及び初級者が45%(スキー39%)であった.受傷原因は滑走中の自己転倒が最多で53%(スキー70%),次いでジャンプによる転倒が29%(スキー3%)であった.受傷部位は上肢が50%(スキー26%)を占め,外傷種類は,骨折が33%(スキー19%),脱臼が11%(スキー5%)と多かった.主な外傷は橈骨遠位端骨折で17%(スキー1%)であったが,頭蓋内出血5例,脊髄損傷3例も認めた.受傷率はスキーの3.0倍,入院率はスキーの3.2倍であった
  • 吉田裕俊, 高橋誠, 川崎修平, 張禎浩, 後藤敏
    臨床整形外科 32 (10) 1099 - 1106 0557-0433 1997/10 [Refereed][Not invited]
  • 高橋誠, 吉田裕俊, 川崎修平, 張禎浩, 後藤敏
    東日本整形災害外科学会雑誌 9 (2) 150 - 153 1342-7784 1997/06 [Refereed][Not invited]
  • H. Nakaguchi, T. Fujimaki, K. Hoya, T. Kirino, H. Yoshida, M. Takahashi, M. Kamata
    Japanese Journal of Neurosurgery 6 (4) 256 - 260 0917-950X 1997 [Refereed][Not invited]
     
    It is said that by the end of the 1995-1996 skiing season, the number of snowboarders will have grown to almost 1 million in Japan. However, it is not generally recognized that snowboarders have a higher risk of serious head injuries than conventional skiers. So far, there have been no detailed epidemiological studies examining the spectrum of head injuries. Our aim in this study is to analyze the pattern and cause of head injuries associated with this relatively new sport. We analyzed 140 cases of trauma associated with snowboarding in the first half of the 1995-1996 skiing season treated at Suwa Central Hospital. Among them there were 26 cases of head and neck injury 81% of the injured patients were male and the mean age was 22 (±2.6 SD) years. The majority (61%) were beginners and 45% of the cases were occipital trauma, and 15% were neck trauma. The most common symptoms were concussion (54%) and peritraumatic anmesia (31%). However 6 of the 26 patients had intracranial organic lesions visualized by CT scans. These comprised 2 cases of small parenchymal contusion, 2 cases of traumatic subarachnoid hemorrhage, 1 case of acute epidural hematoma, 1 case of intracerebral hemorrhage according to avulsion of an arterial perforator. In comparison with injuries to the extremities due to forward falling and hitting the front of extremities, patients with head and neck injury had a tendency to fall backwards and strike the occipital and rear neck regions. As for injuries during jumping, 4 out of 6 beginners who had sustained injuries in this way had intracranial organic lesions visualized by CT scans. Appropriate snowboarding lessons given by certified instructors and the rise of protective devices such as occipital protective helmets are very important for preventing head injuries during snowboarding.

MISC

Books etc

  • 日本専門医機構;総合診療専門医検討委員会 編; 総合診療専門研修公式テキストブック
    高橋誠 (Contributorシームレスな医師養成)
    日経BP 2020/12
  • 福井次矢・高木誠・小室一成 総編集; 今日の治療指針2018年版
    高橋誠 (Contributor関節穿刺)
    医学書院 2018/01
  • 奈良信雄・植竹宏之編：臨床研修 手技・処置ベッドサイド手帖
    高橋誠 (Contributor包帯法)
    メジカルビュー社 2012/09
  • Yonenobu K. et al eds: OPLL 2nd ed.
    Shinomiya K, Matsuoka T, Kurosa Y, Shindo S, Nakai O, Takahashi M (ContributorAnterior Cervical Decompression for Cervical Myelopathy Caused by Ossification of the Posterior Longitudinal Ligament)
    Springer Tokyo 2006/10
  • 越智隆弘編：最新整形外科学大系 第12巻 胸腰椎・腰椎・仙椎
    高橋誠, 小森博達 (Contributor4章 補助診断：画像診断法 単純X線撮影、断層撮影)
    中山書店 2006/09
  • 奈良信雄編：EBMのためのベスロアプローチ
    高橋誠, 宗田大 (Contributor腰痛)
    中外医学社 2006/02
  • 馬場久敏編：脊椎外科の要点と盲点：頚椎
    高橋誠, 四宮謙一 (Contributor後縦靱帯骨化症に対する骨化摘出・浮上術)
    文光堂 2005/10

Presentations

  • Masanaga Yamawaki, Eriko Okada, Nobutoshi Nawa, Yu Akaishi, Shouko Yoshida, Yujiro, Tanaka, Ayako Kashimada, Makoto Takahashi
    AMEE Glasgow 2023  2023/08
  • 臨床研修を練る会議～評価表を練ってみる～
    高橋誠, 近藤昭信, 石原慎, 石丸裕康, 磯部真倫, 伊野美幸, 落合甲太, 松島加代子, 安井浩樹
    第55回日本医学教育学会大会  2023/07
  • 臨床教育のe-portfolioシステム EPOC2の開発
    高橋誠
    第55回日本医学教育学会大会  2023/07
  • CC-EPOCをどのように導入・活用するか？
    高橋誠, 山脇正永, 長谷川仁志, 岡田英理子, 赤石雄
    第55回日本医学教育学会大会  2023/07
  • EPOCの開発経緯/機能紹介
    高橋誠
    第54回日本医学教育学会大会  2022/08
  • 臨床実習の評価（CC-EPOC）の立場から  [Not invited]
    高橋誠
    第54回日本医学教育学会大会  2022/08
  • 何をどう教える？：医学生・研修医の医療安全を担保した医学教育  [Invited]
    高橋誠
    第95回日本整形外科学会学術総会  2022/05
  • What is needed to undergo satisfying clinical clerkships  [Not invited]
    Makoto Takahashi
    The 52nd Annual Meeting of the Japan Society for Medical Education  2020/07
  • Learning strategy and evaluation of under and postgraduate clinical training  [Not invited]
    Makoto Takahashi
    The 52nd Annual Meeting of the Japan Society for Medical Education  2020/07
  • 研修医・専攻医の指導についてー医療安全の観点からー  [Invited]
    高橋誠
    第138回北海道整形災害外科学会  2020/02
  • Updating of the EPOC for 2020  [Not invited]
    Makoto Takahashi
    The 51st Annual Meeting of the Japan Society for Medical Education  2019/07
  • The new EPOC: An evaluation and portfolio system of clinical training  [Not invited]
    Makoto Takahashi
    The 51st Annual Meeting of the Japan Society for Medical Education  2019/07

Association Memberships

  • Association for Medical Education in Europe   HOKKAIDO SOCIETY OF ORTHOPAEDIC AND TRAUMATOLOGY   Japan Primary Care Association   THE JAPAN SOCIETY FOR MEDICAL EDUCATION   THE JAPANESE SOCIETY FOR SPINE SURGERY AND RELATED RESEARCH   THE JAPANESE ORTHOPAEDIC ASSOCIATION   

Research Projects

  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2024/04 -2029/03 
    Author : 石原 慎, 岡崎 史子, 蓮沼 直子, 高橋 誠, 橋本 佳, 廣井 直樹, 寺澤 晃彦, 小松 弘幸, 山内 かづ代, 三好 智子, 伊藤 俊之, 伊藤 彰一, 藤田 博一, 田口 亮, 大久保 由美子, 李 晃伸, 荒川 敏, 栩野 吉弘, 岸 美紀子, 上乃 聖, 鋪野 紀好
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2022/04 -2025/03 
    Author : 村上 学, 高橋 誠, 川畑 秀伸
  • 日本学術振興会：科学研究費助成事業
    Date (from‐to) : 2022/04 -2025/03 
    Author : 岡田 英理子, 高橋 誠, 井津井 康浩, 山脇 正永, 那波 伸敏, 高田 和生
  • 厚生労働省：厚生労働科学研究費補助金
    Date (from‐to) : 2021/04 -2024/03 
    Author : 田中雄二郎, 山脇正永, 岡田英理子, 那波伸敏, 木内貴弘, 髙橋誠, 福井次矢, 高橋理, 大出幸子
  • 日本学術振興会：科学研究費助成事業
    Date (from‐to) : 2020/04 -2023/03 
    Author : 井津井 康浩, 高橋 誠, 岡田 英理子, 山脇 正永, 那波 伸敏, 加藤 浩晃, 田中 雄二郎, 藤原 武男, 高尾 義明
     
    近年、医療ベンチャー主導の技術革新により、疾病予防の推進や健康寿命の延伸をはかることが重要と考えられ、医師によるベンチャー起業が注目されている。 また、各省庁主導の医療ベンチャーサポートプログラムも開発されている。 本研究の目的は、医師が起業する際の促進因子や阻害因子を明らかにし、データ及び理論に基づいた医師の起業教育プログラムを開発すること、起業の自己効力 感及び意図を測定する尺度を開発することである。2020年度は、in-depth interviewを医師起業家、行政官(厚生労働省、経済産業省)、東京医科歯科大学のカリ キュラム開発に関わる教員に対して行い、focus group discussionを東京医科歯科大学の医学部学生に対して2回実施した。約一時間の各セッションは 事前に作成したインタビューガイドを用いて行い、医師が起業をする際の促進因子・阻害因子について調査を行なった。インタビューは同意を得た後に録音し、 逐語的に一語一語文字起こしを行った後、主題分析(Thematic Analysis)を行った。主題分析に用いたコードは、CDCのSocial Eco logical Modelをもとに、個人 の知識、スキルに加え、周囲の友人や家族のサポート、所属するコミュニティーの因子(医局や専門科)、社会的因子(政策等)をコードとするdeductive coding法 を用いて行った。これらの調査を行った後、医師が起業をする際の促進因子・阻害因子について調査した結果を論文にまとめ、Facilitators and barriers to physicians’ entrepreneurial ventures in major Japanese cities: A qualitative studyとして国際学術誌に掲載された。
  • 日本学術振興会：科学研究費助成事業
    Date (from‐to) : 2020/04 -2023/03 
    Author : 木内 貴弘, 佐藤 慎哉, 岡崎 史子, 高橋 誠, 大滝 純司, 首藤 太一, 岡田 英理子, 平形 道人, 小池 宏子, 石川 ひろの, 上野 治香, 伊藤 俊之, 齊藤 延人, 高橋 理, 奥原 剛, 高田 清式, 石田 博, 加藤 美生, 松村 明
     
    2021年度には、2020年度に開発ができなかった機能について、引き続き、システム開発を行い、本研究のシステムの運用に必要な基本的な機能をすべて完成させることができた。このために、具体的に下記を実施した。
    (1)運用による機能・要望の取りまとめ： 4月より研究分担者等によるテスト運用を行い、8月より本番運用を開始して、機能・要望事項の収集と取りまとめをおこなった。 (2)機能・要望のとりまとめ結果に基づき、システム概要設計及びシステム開発を担当する研究分担者の協議により、システム概要設計を行った。 (3)システム詳細設計とプログラミング： システム詳細設計は、システム開発と並行して行った。つまり最も基本的なシステムの大枠をプログラムのプロトタイプモデルとして開発し、これに順次必要な機能を、スパイラルモデルを活用して追加していった。従来一般的であった硬直的なウォーターフォール型での開発を避け、プロトタイプモデル、スパイラルモデルの併用による柔軟な開発を図った。システム開発手法としては、UMINで長年システム開発を行う中で、効率・柔軟性が高いと認められてきた手法を用いた。その特徴は、開発モデルとしてプロトタイプモデルとスパイラルモデルの両方を組み合わせ、開発方法論として、データ中心アプローチを用いることにある。またシステム開発に当たっては、既存のEPOC及びEPOC2のプログラムを可能な範囲で再利用して、必要な労力・コストの削減を図った。
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2018/04 -2022/03 
    Author : Kinoshita Atsuhiro
     
    This study developed computer simulation materials in e-learning (English/Japanese) to learn basic knowledge about Japanese caregiving and experience the technique and situation for international students in their home country before coming to Japan. In order to evaluate the validity of the developed simulation materials, they were provided to medical, nursing, dental, dental hygiene, and graduate students in several courses of the e-learning system (WebClass). As a result, they were generally highly evaluated. Furthermore, it was indicated that the learning method using these materials was effective and useful when the English versions of teaching materials were provided to the Japanese and international learners.
  • 臨床研修の到達目標・方略・評価等の見直しに向けた研究
    厚生労働省：厚生労働行政推進調査事業費補助金
    Date (from‐to) : 2021/04 -2022/03 
    Author : 福井次矢, 大滝純司, 片岡仁美, 高橋理, 髙橋誠, 高村昭輝, 野村英樹, 前野哲博, 村岡亮, 大出幸子, 有岡宏子, 大谷典生
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2018/06 -2020/03 
    Author : Shichinohe Toshiaki
     
    The purpose of this study was to develop an educational system to learn new advanced medical techniques for medical students and to examine the usefulness of clinical anatomy practice consisting of simulated surgery using donated cadavers. The contents of the research were a questionnaire survey of medical students and academics, and a pilot study of simulated endoscopic surgery. The simulated surgery consisted of surgical lectures, demonstrations by surgeons, and hands-on or observational practice by students. These studies showed that both conventional systematic anatomy and newly developed clinical anatomy were useful. It is desirable to introduce clinical anatomy as part of the clinical training curriculum other than conventional anatomy.
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2017/04 -2020/03 
    Author : Takahashi Makoto
     
    The aim of this study was to develop a teaching system for highly-skilled surgical procedures. We developed a simulator for anterior cervical spinal procedures, i.e. the floating method of the ossification of posterior longitudinal ligament (OPLL). This simulator with anatomical characteristics is modeling with salt using a 3-D printer. Also, we created an evaluation system of safety management during operation and mastery level of the anterior cervical procedures. Our simulator and evaluation system would provide high quality and safety teaching methods for highly-skilled surgical procedures.
  • 新たな臨床研修の到達目標・方略・評価を踏まえた指導ガイドラインに関する研究
    厚生労働省：厚生労働行政推進調査事業費
    Date (from‐to) : 2018/04 -2020/03 
    Author : 福井次矢
  • 臨床研修到達目標改定案の研修現場における利用可能性に関する研究
    厚生労働省：厚生労働行政推進調査事業費
    Date (from‐to) : 2017/04 -2018/03 
    Author : 福井次矢
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2014/04 -2017/03 
    Author : TAKAHASHI Makoto
     
    We exhaustively analyzed risk factors when medical students perform phlebotomy or urethral catheterization which are basic clinical procedures. It was suggested that safety management abilities of a teacher could be assessed by exhaustiveness of risk factors which he/she recalls beforehand. We developed a faculty training workshop for safety management on the clinical training, and conducted it on a trial basis. We assigned a task of planning of urethral catheterization training, and requested using process hazard analysis. The participants could list exhaustively the risk factors when medical students urethral catheterization. This workshop seems to be beneficial for faculty development for safety management on the clinical training,
  • 臨床研修の到達目標と連動した研修プログラム及び評価方法・指導方法に 関する研究
    厚生労働省：厚生労働行政推進調査事業費
    Date (from‐to) : 2016/04 -2017/03 
    Author : 福井次矢
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
    Date (from‐to) : 2008 -2010 
    Author : OKAWA Atsushi, TANAKA Yuujirou, YAMWAKI Masanaga, MOMOHARA Yoshihito, TAKAHASHI Makoto
     
    We developed assisting software for Hazard and Operability Study of medicine, which is one of risk analysis methods using in an industrial field. But it was not feasible because of time consuming process. On the other hand, importance of the concept of HAZOP was verified by exercise for medical students, in which a newly-developed bone-drilling simulator was utilized. To evaluate effectiveness of HAZOP exercise of medical students, we compared incident reports written by residents between those who have received HAZOP exercise and those who have not. The results showed no difference between two groups. Patient safety exercise and verification of its educational effectiveness should be continued.
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
    Date (from‐to) : 2007 -2010 
    Author : YAMASHITA Sayoko, KINOSHITA Atsuhiro, OKAWA Atsushi, OKTA YOKO, NAKAMURA Chikako, JUNGHEIM Nicholas, IZUTANI Matazo, TAKAHASHI Makoto, SUNAGA Masayo
     
    1. A questionnaire was administered to 240 persons in order to collect and analyze basic data regarding medical communication education for clinical situations. Subsequently, we analyzed the data consisting of multiple-choice and open-ended questions related to doctor-patient communication. 2. Another survey was conducted of foreign medical students who would be using the e-learning materials in order to understand their needs for such study aids, and we were able to get a grasp of how well that they would be able to work independently in conjunction with a computer using the e-learning materials developed in this project. 3. An investigation and content analysis was carried out on existing communication education materials as part of the basic study to create new ones. We invited Prof. Dennis Novak, a specialist in medical communication from Drexel University's medical school (in the U.S.A.), and held a public lecture. 4. Scripts for interactions in clinical situations were created for independent study materials, and these were used to develop video materials using a digital camera. The titles and scenarios were "Patient Confirmation"-- a dentist/doctor confirms a patient's identity, "An Intravenous Drip Mistake"--an interaction between an inexperienced doctor and a patient during the application of an intravenous drip, "A Patient with Cold Hands and Feet"--dealing with a foreign patient with cold hands and feet who is nervous due to previous examinations, "An Elderly Patient with Back Pain in the Emergency Room"--A young doctor's interaction using young people's language with an elderly patient and an accompanying family member in an emergency room. 5. The e-learning materials were subsequently used by foreign and Japanese medical students who later evaluated the contents by computer. The materials generally were highly evaluated by the students. 6. The results and analysis of the administration of these materials were presented at the 3rd International Wireless Ready Symposium and Leiden University's (The Netherlands) Japanese Linguistics Day, and other conferences. The need for sympathetic communication between doctors and patients is growing. Educational materials that deal with a variety of problematic communication situations such as these are essential, and the use of these independent study materials by foreign medical students as well as Japanese students is very meaningful for the field of medical communication as a whole. 7. All the results of the research described in the above including Dr. Novack's lecture and e-learning materials with videos were published on a website.
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2005 -2007 
    Author : SHINOMIYA Kenichi, AE Keisuke, TAKEDA Shu, SAOTOME Shinichi, ENOMOTO Mitsuhiro
     
    Human bone marrow stromal cells (hBMSCs) are an attractive source for bone tissue engineering applications because of their differentiation capability and their proliferation capability. However, despite the potential of BMSCs, they lose their differentiation potential after multiple doubling processes under standard culture conditions 1. We hypothesized that dexamethasone could augment the responsiveness of BMSCs to differentiation reagents, and continuous dexamethasone treatment would establish BMSCs with higher differentiation potentials. The results of our studies indicated that the dexamethasone-treated cells showed higher osteogenic capability and bone formation capability than the control group. 2. To develop efficient bone regeneration using cells and porous scaffolds, it is essential to introduce an adequate number of cells into porous scaffolds. To improve cell seeding efficiency, we modified the previously reported cell seeding techniques using low-pressure conditions and devised a simple device for this method. The procedures are as follows. In the first step, porous β-TCP blocks are placed into a glass chamber, and in the second step, the air in the chamber is removed by a syringe to create a vacuum. In the third step, the cell suspension is slowly infused into the chamber, maintaining the low-pressure condition, and the blocks are soaked in the suspension. In the final step, the valve is released so that the pressure in the chamber normalizes. Compared to spontaneous penetration (control), cell seeding efficiencies by this method were three fold higher, and the implants prepared by the method showed bone formation more than three folds of the control. 3. We also developed and tested a cell seeding system into porous implants using plasma, expecting that the fibrin network formed from fibrinogen would hold introduced cells within minutes and promote bone formation. BMSCs were suspended in plasma and introduced into porous scaffolds, and fibrin gel was formed within minutes. Then the implants were transplanted. The implants prepared using plasma showed significantly more bone formation than that by the implants using BMSCs suspended in culture medium.
  • 日本学術振興会：科学研究費助成事業
    Date (from‐to) : 2004 -2006 
    Author : 四宮 謙一, 新井 嘉容, 高橋 誠, 河内 敏行
     
    今年度は、前回報告した移植細胞となる胎児海馬由来神経幹細胞(神経幹細胞)と骨髄由来幹細胞(骨髄細胞)のRT-PCR法による神経栄養因子発現の比較から1)NGF・CNTF・GDNF遺伝子およびそれぞれのレセプター遺伝子ベクターを培養神経幹細胞に導入しその分化傾向を確認した。in vivo実験では2)脊髄損傷モデルに移植した細胞の生存期間を改善するような遺伝子導入を行った。 1)NGF・CNTF・GDNFおよびそれぞれの受容体遺伝子を培養神経幹細胞にさまざまな組み合わせで導入実験を行った。その結果、GDNFとそのレセプターGFRα1の組み合わせでもっと高い神経細胞へ分化が認められた。本結果から骨髄細胞が脊髄損傷部に移植された場合、損傷後の機能回復を促進する一因としてGDNFの関与が示唆される。今後は、脊髄損傷後にGDNFを持続的に発現させるモデルを作製し、損傷急性期の炎症の抑制と組み合わせて研究を行っていく予定である。 2)前回、培養神経幹細胞を脊髄損傷1週後に移植した結果、ホスト脊髄内で細胞の生着は確認されたもの正常脊髄に移植したものの約半数しか生着できなかったことを報告した。今回、細胞骨格とアポトーシスに関与するRhoファミリー遺伝子に注目し、神経幹細胞に導入し移植実験を行った。その結果、RacおよびRho遺伝子のdominant negative typeを感染させた場合、対照群と比較して2.5倍の生着細胞が観察された。これら遺伝子は、移植後の細胞死を抑制するための有効な手段と考えられた。 1)2)では損傷脊髄に移植する神経幹細胞、骨髄幹細胞についてその神経栄養因子的な働きと細胞死の抑制方法について明らかにした。骨髄幹細胞の脊髄損傷に対する働きはいまだ不明であり、移植細胞の多くが細胞死を受け十分に生着せず、一過性の働きしか得られないという報告もあることから本研究で明らかにしたことは意義が大きい。いずれの実験結果も論文への投稿準備中である。研究計画にあるような抗炎症作用とダリア瘢痕の抑制環境の作製には時間が必要であるが、本研究で明らかにした手法を組み合わせることで脊髄損傷のメカニズムおよび治療の解明に役立つと思われる。
  • 椎間板変性に関与する遺伝的要因の解析
    (社)日本損害保険協会：交通事故医療研究助成
    Date (from‐to) : 1998/04 -1999/03 
    Author : 高橋誠

Industrial Property Rights

  • 特許3032824:骨誘導促進剤    2000/04/17
    河内敏行, 高橋誠, 四宮謙一  東京医科歯科大学

Social Contribution

  • 研修医の評価とEPOCへの記録について
    Date (from-to) : 2023/08/10-2023/08/10
    Role : Lecturer
    Sponser, Organizer, Publisher  : (NPO)卒後臨床研修評価機構
    Event, Program, Title : 第17回 臨床研修病院事務・実務担当者講習会
  • 医師ってどんな職業？
    Date (from-to) : 2023/08/08-2023/08/08
    Role : Lecturer
    Sponser, Organizer, Publisher  : 北海道教育委員会
    Event, Program, Title : 令和5年度メディカル・キャンプ・セミナー
  • 令和5年度 医学・歯学教育指導者のためのワークショップ
    Date (from-to) : 2023/07/25-2023/07/25
    Role : Presenter
    Sponser, Organizer, Publisher  : 文部科学省
  • 研修医評価とPG-EPOCへの記録について
    Date (from-to) : 2023/07/14-2023/07/14
    Role : Lecturer
    Sponser, Organizer, Publisher  : (NPO)卒後臨床研修評価機構
    Event, Program, Title : 第20回 サーベイヤ－講習会
  • 令和4年度指導医のための教育ワークショップ
    Date (from-to) : 2023/01/28-2023/01/29
    Role : Presenter
    Sponser, Organizer, Publisher  : 北海道・北海道医師会
  • チーム医療って何？～医療福祉に関わる専門職とそれぞれの役割～
    Date (from-to) : 2022/11/29-2022/11/29
    Role : Lecturer
    Sponser, Organizer, Publisher  : 北海道根室高等学校
    Event, Program, Title : 令和4年度高校生メディカル講座
  • 研修医の評価とEPOCへの記録について
    Date (from-to) : 2022/08/12-2022/08/12
    Role : Lecturer
    Sponser, Organizer, Publisher  : (NPO)卒後臨床研修評価機構
    Event, Program, Title : 第16回 臨床研修病院事務・実務担当者講習会
  • 研修医評価とEPOCへの記録について
    Date (from-to) : 2022/07/28-2022/07/28
    Role : Lecturer
    Sponser, Organizer, Publisher  : (NPO)卒後臨床研修評価機構
    Event, Program, Title : 第19回サーベイヤー講習会
  • 令和4年度 医学・歯学教育指導者のためのワークショップ
    Date (from-to) : 2022/07/27-2022/07/27
    Role : Presenter
    Sponser, Organizer, Publisher  : 文部科学省
  • 何をどう教える？－医学生・研修医の医療安全を担保した医学教育－
    Date (from-to) : 2022/05/22-2022/05/22
    Role : Lecturer
    Sponser, Organizer, Publisher  : (公社)日本整形外科学会
    Event, Program, Title : 第95回日本整形外科学会学術総会 教育研修講演64
  • 臨床研修制度の概要
    Date (from-to) : 2022/03/20-2022/03/21
    Role : Lecturer
    Sponser, Organizer, Publisher  : 北海道・北海道医師会
    Event, Program, Title : 令和3年度指導医のための教育ワークショップ
  • 病院ではたらく ～医療職を目指す人へ～
    Date (from-to) : 2022/02/18-2022/02/18
    Role : Lecturer
    Sponser, Organizer, Publisher  : 北海道静内高等学校
    Event, Program, Title : 令和3年度高校生メディカル講座
  • EPOC2 について
    Date (from-to) : 2021/12/07-2021/12/07
    Role : Lecturer
    Sponser, Organizer, Publisher  : (NPO)卒後臨床医研修評価機構
    Event, Program, Title : 第18回サーベイヤー講習会
  • EPOC2 & Post-CC EPOC ～評価：臨床研修から臨床実習まで～
    Date (from-to) : 2021/11/21-2021/11/21
    Role : Lecturer
    Sponser, Organizer, Publisher  : 北海道大学病院
    Event, Program, Title : 第17回北海道大学指導医のための教育ワークショップ
  • 医師ってどんな職業？
    Date (from-to) : 2021/08/10-2021/08/10
    Role : Lecturer
    Sponser, Organizer, Publisher  : 北海道教育委員会
    Event, Program, Title : 令和3年度メディカル・キャンプ・セミナー
  • 医療職に就くまでに学ぶべきこと、必要な資質
    Date (from-to) : 2021/08/02-2021/08/02
    Role : Lecturer
    Sponser, Organizer, Publisher  : 北海道留萌高等学校
    Event, Program, Title : 令和3年度高校生メディカル講座
  • 臨床研修制度の見直しに伴う新たな評価～EPOC2について～
    Date (from-to) : 2021/02/10-2021/02/10
    Role : Lecturer
    Sponser, Organizer, Publisher  : 北海道・厚生労働省北海道厚生局
    Event, Program, Title : 北海道臨床研修病院等連絡協議会・北海道臨床研修制度ブロック協議会
  • 研修医の評価について EPOC2
    Date (from-to) : 2020/11/01-2020/12/06
    Role : Lecturer
    Sponser, Organizer, Publisher  : 臨床研修協議会
    Event, Program, Title : 令和2年度プログラム責任者養成講習会
  • EPOC2 について
    Date (from-to) : 2020/12/02-2020/12/02
    Role : Lecturer
    Sponser, Organizer, Publisher  : (NPO)卒後臨床医研修評価機構
    Event, Program, Title : 第15回臨床研修病院事務担当者講習会
  • チーム医療って何？～医療福祉に関わる専門職とそれぞれの役割～
    Date (from-to) : 2020/11/27-2020/11/27
    Role : Lecturer
    Sponser, Organizer, Publisher  : 北海道根室高等学校
    Event, Program, Title : 令和2年度高校生メディカル講座
  • 医師ってどんな職業？
    Date (from-to) : 2020/08/11-2020/08/11
    Role : Lecturer
    Sponser, Organizer, Publisher  : 北海道教育委員会
    Event, Program, Title : 令和2年度メディカル・キャンプ・セミナー
  • 臨床研修制度の見直し
    Date (from-to) : 2020/02/01-2020/02/02
    Role : Lecturer
    Sponser, Organizer, Publisher  : 北海道・北海道医師会
    Event, Program, Title : 令和元年度指導医のための教育ワークショップ
  • 学習者の評価
    Date (from-to) : 2020/01/28-2020/01/28
    Role : Lecturer
    Sponser, Organizer, Publisher  : 札幌医科大学
    Event, Program, Title : 第2回札幌医科大学FDワークショップ
  • 研修医の評価について EPOC2
    Date (from-to) : 2019/10/06-2019/11/08
    Role : Lecturer
    Sponser, Organizer, Publisher  : 臨床研修協議会
    Event, Program, Title : 令和元年度プログラム責任者養成講習会
  • EPOC ＆ Post-CC OSCE ～学修目標と評価～
    Date (from-to) : 2019/11/02-2019/11/02
    Role : Lecturer
    Sponser, Organizer, Publisher  : 北海道大学病院
    Event, Program, Title : 第16回北海道大学指導医のための教育ワークショップ
  • 医療系の仕事を知る～医療専門職とそれぞれの役割～
    Date (from-to) : 2019/09/28-2019/09/28
    Role : Lecturer
    Sponser, Organizer, Publisher  : 北海道釧路湖陵高等学校
    Event, Program, Title : 令和元年度高校生メディカル講座
  • 医師ってどんな職業？
    Date (from-to) : 2019/08/07-2019/08/07
    Role : Lecturer
    Sponser, Organizer, Publisher  : 北海道教育委員会
    Event, Program, Title : 令和元年度メディカル・キャンプ・セミナー
  • EPOC サーベイヤーとしての活用方法
    Date (from-to) : 2019/08/07-2019/08/07
    Role : Lecturer
    Sponser, Organizer, Publisher  : (NPO)卒後臨床研修評価機構
    Event, Program, Title : 第16回サーベイヤー講習会

Media Coverage

  • 医学教育分野別評価とCC-EPOC
    Date : 2023/03
    Writer: Myself
    Publisher, broadcasting station: (一社)日本医学教育評価機構
    Program, newspaper magazine: JACME Newsletter
    Pr
  • 世界初！医学生の臨床実習から、卒後の初期研修までをシームレスに評価する「CC-EPOC」で期待されるもの
    Date : 2022/06
    Publisher, broadcasting station: 損害保険ジャパン株式会社
    Program, newspaper magazine: Risk Management Times
    Pr
  • Date : 2021/06/14
    Writer: Myself
    Publisher, broadcasting station: 医学書院
    Program, newspaper magazine: 週間医学界新聞
    Paper
  • 医学部生の臨床実習内容をスマホで記録 全国統一システムを開発
    Date : 2021/03/17
    Writer: Other than myself
    Publisher, broadcasting station: 読売新聞
    Program, newspaper magazine: yomiDr. ヨミドクター
    https://yomidr.yomiuri.co.jp/article/20210315-OYTET50015/ Internet

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