Researcher Profile and Settings

Affiliation

• Faculty of Education　Education　Science of Health and Physical Education

Job Title

• Associate Professor

URL

http://yamanaka-lab.wix.com/chronobiology

Research funding number

• 20528343

J-Global ID

• 200901005272778779

Research Interests

• 体内時計   生物時計   身体運動   生体リズム   時計遺伝子   生物発光   環境生理   時差ボケ   マウス   スポーツ科学   スポーツ生理学   リズム同調   メラトニン   システム   行動リズム   睡眠   

Research Areas

• Life sciences / Neuroscience - general
• Life sciences / Nutrition and health science
• Life sciences / Sports science
• Life sciences / Physiology
• Life sciences / Physiology / Chronobiology

Educational Organization

•  Bachelor's degree program　School of Education
•  Master's degree program　Graduate School of Education
•  Doctoral (PhD) degree program　Graduate School of Education

Academic & Professional Experience

• 2018/04 - Today 北海道大学健康科学研究教育センター兼務教員
• 2016/04 - Today Hokkaido University Research and Education Center for Brain Science
• 2016/04 - Today Hokkaido University Faculty of Education
• 2010/05 - 2016/03 Hokkaido University
• 2009/04 - 2010/04 Hokkaido University
• 2008/07 - 2009/03 Hokkaido University

Education

• 2004/04 - 2008/06  北海道大学大学院

Association Memberships

• Society for Research on Biological Rhythms   日本生理学会   日本睡眠学会   日本時間生物学会   

Research Activities

Published Papers

• Two oscillatory components detected by forced splitting of the sleep-wake cycle in humans.

  Satoko Hashimoto, Takuro Endo, Sato Honma, Yujiro Yamanaka, Ken-Ichi Honma

  American journal of physiology. Regulatory, integrative and comparative physiology 326 (1) R19-R28  2024/01/01 

  The sleep-wake cycle of human subjects was artificially split into two episodes by imposing an 8-h light and 4-h dark cycle (LD 8:4) twice a day for 7 days, which was followed by a 3-day free-running session. Sleep was permitted only in the dark period. The subjects in the ordinary group were exposed to ordinary light (ca. 500 lx) in the 8-h light period, and those in the bright light group to bright (ca. 5,000 lx) and ordinary light alternatively with bright light after the first dark period (2400-400). Split sleeps persisted in the free-running session with the major episode around the first dark period and the minor episode around the second dark period. By contrast, circadian melatonin rhythm in the free-running session significantly phase delayed in the ordinary light group, but phase advanced in the bright light group, keeping the melatonin rhythm unsplit. The length of nocturnal melatonin secretion (NMS) was significantly shortened in the bright light group. Interestingly, the falling phase of NMS advanced significantly further than the rising phase. Such a difference was not detected in the ordinary light group. Similar differences were observed in the body temperature rhythm. These findings indicated oscillatory mechanisms underlying split sleeps distinct from the circadian pacemaker and suggested an involvement of different circadian oscillators in the rising and falling phases of NMS, which is consistent with the dual oscillator model proposed for the circadian system of nocturnal rodents.NEW & NOTEWORTHY The present study demonstrated that human sleep was separated into two essentially identical components, which persisted under constant conditions, suggesting circadian oscillator underlying split-sleep episodes. The study also indicated differential light sensitivities in the rising and falling phases of circadian melatonin rhythm, indicating the involvement of two different oscillators. These results consisted of the evening and morning dual-oscillator hypothesis for the circadian pacemaker and the hierarchical model for the pacemaker and sleep-wake cycle.
• Differential responses to artificial photoperiods of the rising and falling phases of human melatonin rhythm are consistent with a dual oscillator hypothesis.

  Satoko Hashimoto, Takuro Endo, Sato Honma, Yujiro Yamanaka, Ken-Ichi Honma

  American journal of physiology. Regulatory, integrative and comparative physiology 325 (5) R619-R628  2023/11/01 

  Circadian rhythms and sleep-wake cycles were measured in volunteers staying singly in temporal isolation unit where they were exposed to artificial short and long light-dark (LD) cycles for 7 days. The long day consisted of 16-h light and 8-h dark (LD 16:8) and the short day consisted of 8-h light and 16-h dark (LD 8:16). During the light period, bright light of approximately 5,000 lux was given from the ceiling and during the dark period there was no illumination. Sleep was monitored by bed sensors, wrist actiwatch, and polysomnography (PSG) on the first and last nights of the schedule. Sleep length was significantly longer under LD 8:16 than under LD 16:8 and the sleep quality estimated by PSG was worse under LD 8:16 than under LD 16:8, which were comparable to natural seasonality in sleep. The circadian rhythm in plasma melatonin was measured in dim light (10 lux) before and after the LD exposures. The nocturnal melatonin secretion (NMS) was significantly longer after LD 8:16 than after LD 16:8 due to differential phase shifts of the rising and falling phases of NMS. After LD 8:16, the falling phase was much advanced than the rising phase, whereas after LD 16:8 the rising phase was much delayed than the falling phase, resulting in the NMS compression. These results indicate that the light sensitivity in terms of phase shifting is different in the two circadian phases, supporting a dual oscillator hypothesis with different phase-response curves for light in the human circadian system.NEW & NOTEWORTHY The present study demonstrated differential light responsiveness of the rising and falling phases of nocturnal melatonin secretion in human subjects exposed to artificial long (LD 16:8) and short days (LD 8:16) and suggested the involvement of different oscillators under these phases. The findings well mimicked the seasonality of the circadian rhythms in nature and consisted with the evening/morning dual oscillator hypothesis proposed originally for nocturnal rodents, providing a new concept for the human circadian system.
• Nonphotic entrainment of central and peripheral circadian clocks in mice by scheduled voluntary exercise under constant darkness.

  Ren Y Sato, Yujiro Yamanaka

  American journal of physiology. Regulatory, integrative and comparative physiology 2023/02/20 

  In mammals, the central circadian pacemaker in the suprachiasmatic nucleus (SCN) entrains to an environmental light-dark (LD) cycle and organizes the temporal order of circadian rhythms in physiology and behavior. Previously, some studies have demonstrated that scheduled exercise could entrain the free-running behavior rhythm in nocturnal rodents. However, it remains unknown whether entrainment by scheduled exercise alters the internal temporal order of the behavioral circadian rhythms or clock gene expression in the SCN, extra-SCN brain regions, and peripheral organs when mice are entrained to the scheduled exercise under constant darkness (DD). In the present study, we examined circadian rhythms in locomotor activity and Per1-luc rhythms in the SCN, arcuate nucleus (ARC), liver, and skeletal muscle of mice entrained to an LD, mice free-running under DD and mice entrained to daily exposure to a new cage with a running wheel (NCRW) under DD. All mice showed a steady-state entrainment of behavioral circadian rhythms to NCRW exposure under DD in parallel with shortening the alpha when compared to that under DD. The temporal order of behavioral circadian rhythms and the Per1-luc rhythms in the SCN and peripheral tissues but not in the ARC were maintained in the mice entrained to the NCRW and LD cycles; in contrast, the temporal order was altered in the mice under DD. The present findings reveal that the SCN entrains to daily exercise, and daily exercise reorganizes the internal temporal order of behavioral circadian rhythms and clock gene expression in the SCN and peripheral tissues.
• [Impacts of mastication frequency on circadian rhythm of glucose metabolism].

  Yujiro Yamanaka

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica 158 (2) 165 - 168 2023 

  Postprandial glucose concentration is dependent on the time of day and its concentration in the morning is lower than in the evening. The circadian rhythm of glucose metabolism is regulated by the central circadian pacemaker in the suprachiasmatic nucleus (SCN). Both the SCN circadian clock and the pancreatic clock play important role in generating and maintaining the circadian rhythm of glucose metabolism. Also, short sleep duration and circadian misalignment are closely associated with a decrease in insulin sensitivity and an increase in type2 diabetes. Increased frequency of mastication and/or thorough chewing has been reported to alter the secretion of hormones related to appetite and energy metabolism. Furthermore, we have reported that the effect of mastication on postprandial glucose metabolism is dependent on the time of day and frequency of mastication. Morning mastication but not evening decreases postprandial blood glucose concentrations and increases insulin secretion at 30 min and so-called the insulinogenic index as a marker of early-phase β-cell function. This novel finding may aid in reducing the incidence of obesity and type 2 diabetes mellitus. This review covers the basic concept of the mammalian human circadian system, the underlying mechanism causing phase adjustment of the circadian rhythms in the SCN and peripheral organs, and the effect of eating behavior (e.g., chewing frequency) on the circadian rhythm of glucose metabolism.
• Time of Day of Vaccination Does Not Associate With SARS-CoV-2 Antibody Titer Following First Dose of mRNA COVID-19 Vaccine.

  Yujiro Yamanaka, Isao Yokota, Atsushi Yasumoto, Eriko Morishita, Hisanori Horiuchi

  Journal of biological rhythms 37 (6) 7487304221124661 - 7487304221124661 2022/09/26 

  The immune system exhibits circadian rhythms, and its response to viral infection is influenced by the circadian clock system. Previous studies have reported associations between the time of day of vaccination against COVID-19 and production of anti-SARS-CoV-2 antibody titer. We examined the effect of vaccination time of day on anti-SARS-CoV-2 antibody titer after the first dose of vaccination with the mRNA-1273 (Moderna) COVID-19 vaccine in an adult population. A total of 332 Japanese adults participated in the present study. All participants were not infected with SARS-CoV-2 and had already received the first dose of mRNA-1273 2 to 4 weeks prior to participating in the study. The participants were asked to provide basic demographic characteristics (age, sex, medical history, allergy, medication, and mean sleep duration), the number of days after the first dose of vaccination, and the time of day of vaccination. Blood was collected from the participants, and SARS-CoV-2 antibody titers were measured. Ordinary least square regression was used for assessing the relationship between basic demographic characteristics, number of days after vaccination, time of day of vaccination, and the log10-transformed normalized antibody titer. The least square mean of antibody titers was not associated with the vaccination time and sleep durations. The least square means of antibody titers was associated with age; the antibody titers decreased in people aged 50 to 59 years and 60 to 64 years. The present findings demonstrate that the vaccination time with mRNA-1273 was not associated with the SARS-CoV-2 antibody titer in an adult population, suggesting that these results do not support restricting vaccination to a particular time of day. The present findings may be useful in optimizing SARS-CoV-2 vaccination strategies.
• Correction to: Effects of Lactococcus lactis subsp. cremoris YRC3780 daily intake on the HPA axis response to acute psychological stress in healthy Japanese men.

  Noriko Matsuura, Hidemasa Motoshima, Kenji Uchida, Yujiro Yamanaka

  European journal of clinical nutrition 2022/05/10
• A fixed single meal in the subjective day prevents free-running of the human sleep-wake cycle but not of the circadian pacemaker under temporal isolation.

  Yujiro Yamanaka, Satoko Hashimoto, Aya Honma, Sato Honma, Ken-Ichi Honma

  American journal of physiology. Regulatory, integrative and comparative physiology 2022/04/26 [Refereed][Not invited]
   

  Effects of a fixed single meal per day were examined on the circadian pacemaker and sleep-wake cycle in subjects under temporal isolation. When the time of single meal was allowed to take at any time of day (Ad-lib meal), the sleep-wake cycle as well as the circadian rhythms in plasma melatonin, cortisol and core body temperature were significantly phase-delayed in 8 days. On the other hand, when the time of meal was fixed at 1800 h in local time (RF meal), the phase-shift of sleep-wake cycle was not significant, while those of the circadian rhythms were significant. The differential effects of a fixed single meal schedule were confirmed in most individual subjects. There was no evidence for the prefeeding increase in plasma cortisol and leptin levels under the fixed single meal schedule. The plasma ghrelin level was apparently high before meal in both Ad-lib and RF meal groups, which was, however, likely sculptured by a non-specific prandial drop and gradual increase after meal intake. Single meal augmented the prandial increase of plasma insulin levels by 4-5 times. These findings indicate that a single meal at fixed time of day during the subjective day failed to prevent the human circadian pacemaker but prevented the sleep-wake cycle to free-run at least 8 days under temporal isolation, suggesting that meal time was a potent non-photic time cue for the human sleep-wake cycle.
• Effects of different light incident angles via a head-mounted device on the magnitude of nocturnal melatonin suppression in healthy young subjects

  Naoko Kubota, Yusuke Tamori, Kenkichi Baba, Yujiro Yamanaka

  Sleep and Biological Rhythms 2022/01/21 [Refereed][Not invited]
  
• Effects of Lactococcus lactis subsp. cremoris YRC3780 daily intake on the HPA axis response to acute psychological stress in healthy Japanese men

  Noriko Matsuura, Hidemasa Motoshima, Kenji Uchida, Yujiro Yamanaka

  European Journal of Clinical Nutrition 0954-3007 2021/08/04 [Refereed][Not invited]
   

  Lactococcus lactis subsp. cremoris (YRC3780), which is isolated from kefir, has been associated with anti-allergic effects in humans. However, it remains unknown whether daily intake of YRC3780 attenuates the response to psychological stress in humans in parallel with changes to the gut microbiome. We examined the fundamental role of YRC3780 in the gut microbiome, stress response, sleep, and mental health in humans. Effects of daily intake of YRC3780 on the hypothalamic-pituitary-adrenal (HPA) axis response to acute psychological stress were investigated in a double-blind, placebo-controlled clinical trial involving 27 healthy young men (mean age and body mass index: 23.5 years and 21.5 kg/m²) who were randomly assigned to placebo (n = 13) or YRC3780 (n = 14) groups. The HPA axis response to acute psychological stress, the diurnal rhythm of HPA axis activity, and gut microbiome were assessed and compared between the two groups. The results showed that daily intake of YRC3780 significantly lowered morning salivary cortisol levels compared with placebo. In addition, salivary cortisol levels following a social stress test significantly decreased +40 min after beginning the TSST in the YRC3780-treated group compared to placebo. There were no significant differences between the two groups in terms of actigraphy-based sleep quality, but the subjective sleep quality and mental health were significantly improved in the YRC3780-treated group compared to placebo. Our study suggests that daily intake of YRC3780 improves the HPA axis response to acute psychological stress, which might be associated with a decrease in morning cortisol levels.
• Basic concepts and unique features of human circadian rhythms: implications for human health.

  Yujiro Yamanaka

  Nutrition reviews 78 (Supplement_3) 91 - 96 2020/12/01 [Refereed][Invited]
   

  Most physiological functions and behaviors exhibit a robust approximately 24-hour rhythmicity (circadian rhythm) in the real world. These rhythms persist under constant conditions, but the period is slightly longer than 24 hours, suggesting that circadian rhythms are endogenously driven by an internal, self-sustained oscillator. In mammals, including humans, the central circadian pacemaker is located in the hypothalamic suprachiasmatic nucleus. The primary zeitgeber for this pacemaker is bright sunlight, but nonphotic time cues also affect circadian rhythms. The human circadian system uniquely exhibits spontaneous internal desynchronization between the sleep-wake cycle and core body temperature rhythm under constant conditions and partial entrainment of the sleep-wake cycle in response to nonphotic time cues. Experimental and clinical studies of human circadian rhythms must take into account these unique features. This review covers the basic concepts and unique features of the human circadian system, the mechanisms underlying phase adjustment of the circadian rhythms by light and nonphotic time cues (eg, physical exercise), and the effects of eating behavior (eg, chewing frequency) on the circadian rhythm of glucose metabolism.
• Morning Mastication Enhances Postprandial Glucose Metabolism in Healthy Young Subjects

  Arisa Sato, Yoshinori Ohtsuka, Yujiro Yamanaka

  Tohoku Journal of Experimental Medicine 249 (3) 193 - 201 2019/11 [Refereed][Not invited]
  
• Hypothalamic-pituitary-adrenal axis differentially responses to morning and evening psychological stress in healthy subjects.

  Yamanaka Y, Motoshima H, Uchida K

  Neuropsychopharmacology reports 39 (1) 41 - 47 2019/03 [Refereed][Not invited]
  
• Cryptochrome deficiency enhances transcription but reduces protein levels of pineal Aanat

  Yamanaka Y, Yamada Y, Honma KI, Honma S

  Journal of molecular endocrinology 61 (4) 219 - 229 0952-5041 2018/10 [Refereed][Not invited]
  
• Two Coupled Circadian Oscillators Are Involved in Nonphotic Acceleration of Reentrainment to Shifted Light Cycles in Mice.

  Yamanaka Y, Honma S, Honma KI

  Journal of biological rhythms 33 (6) 748730418796300 - 625 0748-7304 2018/09 [Refereed][Not invited]
  
• Phase-adjustment of human circadian rhythms by light and physical exercise.

  Yamanaka Y, Waterhouse J

  The Journal of Physical Fitness and Sports Medicine 5 (4) 287 - 299 2016/10/03 [Refereed][Invited]
  
• Mistimed wheel running interferes with re-entrainment of circadian Per1 rhythms in the mouse skeletal muscle and lung

  Yujiro Yamanaka, Sato Honma, Ken-ichi Honma

  GENES TO CELLS 21 (3) 264 - 274 1356-9597 2016/03 [Refereed][Not invited]
   

  Previously, we showed the acceleration of re-entrainment to 8-h phase-advanced light/dark cycles (LD) in the circadian Per1 expression rhythms of the mouse lung and skeletal muscle by 3-h wheel running (WR) at the beginning of shifted dark phase. In the present study, the effects of WR at the end of shifted dark phase were examined on the re-entrainment in mice. LD was advanced by shortening and was delayed by lengthening the first light period in the phase-advance and phase-delay protocol, respectively. Shifted LD was continued for 4days, which was followed by constant darkness (DD). Per1 expression was measured in the cultured tissues obtained on the first day of DD from mice carrying a bioluminescence reporter of Per1 expression. In the phase-advance protocol, re-entrainment was not influenced by WR in any circadian rhythm examined. In the phase-delay protocol, re-entrainment of the circadian locomotor rhythm was not affected by WR. However, re-entrainment of circadian Per1 rhythm was significantly decelerated in the skeletal muscle and lung. These findings indicate that the effects of WR on re-entrainment depend on the time of day and the peripheral tissues. Mistimed WR interferes with re-entrainment of circadian rhythms in the lung and skeletal muscle.
• Morning and evening physical exercise differentially regulate the autonomic nervous system during nocturnal sleep in humans

  Yujiro Yamanaka, Satoko Hashimoto, Nana N. Takasu, Yusuke Tanahashi, Shin-ya Nishide, Sato Honma, Ken-ichi Honma

  AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 309 (9) R1112 - R1121 0363-6119 2015/11 [Refereed][Not invited]
   

  Effects of daily physical exercise in the morning or in the evening were examined on circadian rhythms in plasma melatonin and core body temperature of healthy young males who stayed in an experimental facility for 7 days under dim light conditions (< 10 lux). Sleep polysomnogram (PSG) and heart rate variability (HRV) were also measured. Subjects performed 2-h intermittent physical exercise with a bicycle ergometer at ZT3 or at ZT10 for four consecutive days, where zeitgeber time 0 (ZT0) was the time of wake-up. The rising phase of plasma melatonin rhythm was delayed by 1.1 h without exercise. Phase-delay shifts of a similar extent were detected by morning and evening exercise. But the falling phase shifted only after evening exercise by 1.0 h. The sleep PSG did not change after morning exercise, while Stage 1 + 2 sleep significantly decreased by 13.0% without exercise, and RE sleep decreased by 10.5% after evening exercise. The nocturnal decline of rectal temperature was attenuated by evening exercise, but not by morning exercise. HRV during sleep changed differentially. Very low frequency (VLF) waves increased without exercise. VLF, low frequency (LF), and high frequency (HF) waves increased after morning exercise, whereas HR increased after evening exercise. Morning exercise eventually enhanced the parasympathetic activity, as indicated by HRV, while evening exercise activated the sympathetic activity, as indicated by increase in heart rate in the following nocturnal sleep. These findings indicated differential effects of morning and evening exercise on the circadian melatonin rhythm, PSG, and HRV.
• 食事時刻がヒトの生体リズムおよびエネルギー代謝調節に与える影響

  山仲 勇二郎, 橋本 聡子, 山田 淑子, 本間 研一

  デサントスポーツ科学 (公財)石本記念デサントスポーツ科学振興財団 36 50 - 60 0285-5739 2015/06 [Refereed][Not invited]
   

  本研究では,健康成人男性を対象に外界の昼夜変化や時刻情報を排除した時間隔離実験室内でヒトの生物時計機構に他のほ乳類で報告されている食事時刻を予知する食事時刻依存性概日リズムが出現するか,規則的な食事スケジュールにヒトの生物時計が同調するかを検証した.実験では,健常成人男性が15日間隔離実験室に滞在し,1日1食の食事スケジュールを8日間おこなった.実験室内の光照度は200lux未満の低照度に設定した.その際,食事時刻を一定時刻に固定した群(食事固定群,5名)と被験者自身が決める群(食事自由群,5名)の2群にわけ,1日1食の食事スケジュールに対する睡眠覚醒リズム,血中ホルモンリズムの変化を調べた.その結果,食事固定群,食事自由群共に,今回調べたメラトニン,コルチゾル,インスリン,グレリン,レプチンには,食事前のホルモン濃度の上昇はみられなかった.睡眠覚醒リズムは両実験群共に実験期間中に有意な位相変化は認められず,24時間周期を示した.血中メラトニンのリズムは,1日1食の食事スケジュール後では両群共に有意に位相後退した.以上より,本実験条件ではヒトの食事時刻依存性概日リズムは発現しないこと,1日1回の食事スケジュールは睡眠覚醒リズムの同調因子として作用するが,生物時計には影響しないことが示唆された.(著者抄録)
• Differential regulation of circadian melatonin rhythm and sleep-wake cycle by bright lights and nonphotic time cues in humans

  Yujiro Yamanaka, Satoko Hashimoto, Satoru Masubuchi, Akiyo Natsubori, Shin-ya Nishide, Sato Honma, Ken-ichi Honma

  AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 307 (5) R546 - R557 0363-6119 2014/09 [Refereed][Not invited]
   

  Our previous study demonstrated that physical exercise under dim lights (<10 lux) accelerated reentrainment of the sleep-wake cycle but not the circadian melatonin rhythm to an 8-h phase-advanced sleep schedule, indicating differential effects of physical exercise on the human circadian system. The present study examined the effects of bright light (>5,000 lux) on exercise-induced acceleration of reentrainment because timed bright lights are known to reset the circadian pacemaker. Fifteen male subjects spent 12 days in temporal isolation. The sleep schedule was advanced from habitual sleep times by 8 h for 4 days, which was followed by a free-run session. In the shift session, bright lights were given during the waking time. Subjects in the exercise group performed 2-h bicycle running twice a day. Subjects in the control kept quiet. As a result, the sleep-wake cycle was fully entrained by the shift schedule in both groups. Bright light may strengthen the resetting potency of the shift schedule. By contrast, the circadian melatonin rhythm was phase-advanced by 6.9 h on average in the exercise group but only by 2.0 h in the control. Thus physical exercise prevented otherwise unavoidable internal desynchronization. Polysomnographical analyses revealed that deterioration of sleep quality by shift schedule was protected by physical exercise under bright lights. These findings indicate differential regulation of sleep-wake cycle and circadian melatonin rhythm by physical exercise in humans. The melatonin rhythm is regulated primarily by bright lights, whereas the sleep-wake cycle is by nonphotic time cues, such as physical exercise and shift schedule.
• Daily exposure to a running wheel entrains circadian rhythms in mice in parallel with development of an increase in spontaneous movement prior to running-wheel access

  Yujiro Yamanaka, Sato Honma, Ken-ichi Honma

  AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 305 (11) R1367 - R1375 0363-6119 2013/12 [Refereed][Not invited]
   

  Entrainment of circadian behavior rhythms by daily exposure to a running wheel was examined in mice under constant darkness. Spontaneous movement was individually monitored for more than 6 mo by a thermal sensor. After establishment of steady-state free running, mice were placed in a different cage equipped with a running-wheel for 3 h once per day at 6 AM. The daily exchange was continued for 80 days. The number of wheel revolutions during exposure to the running wheel was also measured simultaneously with spontaneous movement. In 13 out of 17 mice, circadian behavior rhythm was entrained by daily wheel exposure, showing a period indistinguishable from 24 h. The entrainment occurred in parallel with an increase in spontaneous movement immediately prior to the daily wheel exposure. A similar preexposure increase was observed in only one of four nonentrained mice. The preexposure increase appeared in 19.5 days on average after the start of daily wheel exposure and persisted for 36 days on average after the termination of the exposure schedule. The preexposure increase was detected only when daily wheel exposure came into the activity phase of the circadian behavior rhythm, which was accompanied by an increase in the number of wheel revolutions. These findings indicate that a novel oscillation with a circadian period is induced in mice by daily exposure to a running wheel at a fixed time of day and suggest that the oscillation is involved in the nonphotic entrainment of circadian rhythms in spontaneous movement.
• 低温暴露による新生ラットの概日時計の位相シフト.

  吉川朋子, 松野亜美, 山仲勇二郎, 西出真也, 本間さと, 本間研一

  北海道医誌 88 (2) 89 - 89 0367-6102 2013/04 [Not refereed][Not invited]
  
• Daily exposure to cold phase-shifts the circadian clock of neonatal rats in vivo

  Tomoko Yoshikawa, Ami Matsuno, Yujiro Yamanaka, Shin-ya Nishide, Sato Honma, Ken-ichi Honma

  European Journal of Neuroscience 37 (3) 491 - 497 0953-816X 2013/02 [Refereed][Not invited]
   

  Maternal rhythms entrain the prenatal and neonatal circadian clock in the suprachiasmatic nucleus (SCN) before light entrainment is established. However, the responsible time cues for maternal entrainment are not identified. To examine the role of cyclic changes of ambient temperature in maternal entrainment, blind neonatal rats carrying a clock gene (Per2) bioluminescence reporter were exposed to either of three ambient temperatures (10, 20 or 30°C) during 6-h maternal separation in the early light phase. Cold exposure was performed from postnatal day 1 (P1) to P5. On P6, the SCN was harvested and cultured for photometric monitoring of the circadian rhythm in Per2 expression. Here we demonstrate that the daily cold exposure phase-delayed the circadian Per2 expression rhythms at P6 in a temperature-dependent manner. Exposure to 10°C produced the largest phase-shift of 12.7h, and exposure to 20 and 30°C yielded moderate shifts of 4.1 and 4.5h, respectively. There was no significant difference in the phase-shifts between the latter two temperatures, indicating that ambient temperature is not the sole factor for the phase-shift. Behavioral rhythms that developed after weaning reflected the phase-shift of clock gene expression rhythm in the SCN. These findings indicate that a daily exposure to an ambient temperature of 10°C during the neonatal period is capable of resetting the circadian clock in the SCN, but other factors yet unidentified are also involved in maternal entrainment. Maternal rhythms entrain the prenatal and neonatal circadian clock in the suprachiasmatic nucleus (SCN) before light entrainment is established. However, the responsible time cues for maternal entrainment are not identified. © 2012 Federation of European Neuroscience Societies and Blackwell Publishing Ltd.
• Loss of circadian rhythm and light-induced suppression of pineal melatonin levels in Cry1 and Cry2 double-deficient mice

  Yujiro Yamanaka, Yohko Suzuki, Takeshi Todo, Ken-ichi Honma, Sato Honma

  GENES TO CELLS 15 (10) 1063 - 1071 1356-9597 2010/10 [Refereed][Not invited]
   

  Cryptochrome 1 and 2 (Cry1 and Cry2) are considered essential for generating circadian rhythms in mammals. The role of Cry1 and Cry2 in circadian rhythm expression and acute light-induced suppression of pineal melatonin was assessed using Cry1 and Cry2 double-deficient mice (Cry1-/-/Cry2-/-) developed from the C3H strain that synthesizes melatonin. We examined the circadian variation of pineal melatonin under a 12:12-h light-dark (LD) cycle and constant darkness (DD). Light suppression of pineal melatonin concentration was analyzed by subjecting a 30-min light pulse at the peak phase of melatonin concentration. Wild-type mice showed significant rhythmicity in pineal melatonin concentration with the highest level at Zeitgeber time 22 (ZT22, where time of light on was defined as ZT0) under LD or ZT18 on the first day of DD. In contrast, Cry1-/-/Cry2-/- mice did not show significant circadian rhythmicity, with only a small peak observed at ZT22 in LD. Nevertheless, a significant daily variation could be observed under DD, with a small increase at ZT6 and ZT18 h. Melatonin concentration was significantly suppressed by acute light pulse at ZT22 in wild-type mice but not in Cry1-/-/Cry2-/- mice. The present results suggest that Cry genes are required for regulating pineal melatonin synthesis via circadian and photic signals from the suprachiasmatic nucleus of the hypothalamus (SCN).
• Physical exercise accelerates reentrainment of human sleep-wake cycle but not of plasma melatonin rhythm to 8-h phase-advanced sleep schedule

  Yujiro Yamanaka, Satoko Hashimoto, Yusuke Tanahashi, Shin-ya Nishide, Sato Honma, Ken-ichi Honma

  AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 298 (3) R681 - R691 0363-6119 2010/03 [Refereed][Not invited]
   

  Yamanaka Y, Hashimoto S, Tanahashi Y, Nishide S, Honma S, Honma K. Physical exercise accelerates reentrainment of human sleep-wake cycle but not of plasma melatonin rhythm to 8-h phase-advanced sleep schedule. Am J Physiol Regul Integr Comp Physiol 298: R681-R691, 2010. First published December 30, 2009; doi:10.1152/ajpregu.00345.2009.-Effects of timed physical exercise were examined on the reentrainment of sleep-wake cycle and circadian rhythms to an 8-h phase-advanced sleep schedule. Seventeen male adults spent 12 days in a temporal isolation facility with dim light conditions (<10 lux). The sleep schedule was phase-advanced by 8 h from their habitual sleep times for 4 days, which was followed by a free-run session for 6 days, during which the subjects were deprived of time cues. During the shift schedule, the exercise group (n = 9) performed physical exercise with a bicycle ergometer in the early and middle waking period for 2 h each. The control group (n = 8) sat on a chair at those times. Their sleep-wake cycles were monitored every day by polysomnography and/or weight sensor equipped with a bed. The circadian rhythm in plasma melatonin was measured on the baseline day before phase shift: on the 4th day of shift schedule and the 5th day of free-run. As a result, the sleep-onset on the first day of free-run in the exercise group was significantly phase-advanced from that in the control and from the baseline. On the other hand, the circadian melatonin rhythm was significantly phase-delayed in the both groups, showing internal desynchronization of the circadian rhythms. The sleep-wake cycle resynchronized to the melatonin rhythm by either phase-advance or phase-delay shifts in the free-run session. These findings indicate that the reentrainment of the sleep-wake cycle to a phase-advanced schedule occurs independent of the circadian pacemaker and is accelerated by timed physical exercise.
• [Daily phase adjustment of human sleep-wake cycle]

  Yamanaka Y, Honma S, Honma K

  Nippon rinsho. Japanese journal of clinical medicine 8 67 (8) 1475 - 1482 0047-1852 2009/08 [Refereed][Not invited]
  
• Scheduled exposures to a novel environment with a running-wheel differentially accelerate re-entrainment of mice peripheral clocks to new light-dark cycles

  Yujiro Yamanaka, Sato Honma, Ken-Ichi Honma

  Genes to Cells 13 (5) 497 - 507 1356-9597 2008/05 [Refereed][Not invited]
   

  Effects of scheduled exposures to novel environment with a running-wheel were examined on re-entrainment to 8 h shifted light-dark (LD) cycles of mouse circadian rhythms in locomotor activity and clock gene, Per1, expression in the suprachiasmatic nucleus (SCN) and peripheral tissues. Per1 expression was monitored by a bioluminescence reporter introduced into mice. The animals were exposed to the novel environment for 3 h from the shifted dark onset for four cycles and released into constant darkness. In the phase-advance shift, the circadian rhythm in locomotor activity fully re-entrained in the exposed group, whereas it was in transients in the control. On the other hand, the circadian rhythm of Per1 expression in the SCN almost completely re-entrained in both the control and exposed groups. In the skeletal muscle and lung, the circadian rhythm fully re-entrained in the exposed group, whereas the rhythms in the control did not. In the phase-delay shift, the circadian rhythms in locomotor activity and Per1 expression almost completely re-entrained in both groups. These findings indicate that the scheduled exposures to novel environment with a running-wheel differentially accelerate the re-entrainment of the mouse peripheral clocks to 8 h phase-advanced LD cycles. © 2008 The Authors Journal compilation © 2008 Blackwell Publishing Inc.
• Scheduled exposures to a novel environment with a running-wheel differentially accelerate re-entrainment of mice peripheral clocks to new light-dark cycles

  Yujiro Yamanaka, Sato Honma, Ken-ichi Honma

  GENES TO CELLS 13 (5) 497 - 507 1356-9597 2008/05 [Refereed][Not invited]
   

  Effects of scheduled exposures to novel environment with a running-wheel were examined on re-entrainment to 8 h shifted light-dark (LD) cycles of mouse circadian rhythms in locomotor activity and clock gene, Per1, expression in the suprachiasmatic nucleus (SCN) and peripheral tissues. Per1 expression was monitored by a bioluminescence reporter introduced into mice. The animals were exposed to the novel environment for 3 h from the shifted dark onset for four cycles and released into constant darkness. In the phase-advance shift, the circadian rhythm in locomotor activity fully re-entrained in the exposed group, whereas it was in transients in the control. On the other hand, the circadian rhythm of Per1 expression in the SCN almost completely re-entrained in both the control and exposed groups. In the skeletal muscle and lung, the circadian rhythm fully re-entrained in the exposed group, whereas the rhythms in the control did not. In the phase-delay shift, the circadian rhythms in locomotor activity and Per1 expression almost completely re-entrained in both groups. These findings indicate that the scheduled exposures to novel environment with a running-wheel differentially accelerate the re-entrainment of the mouse peripheral clocks to 8 h phase-advanced LD cycles.
• Repeated exposures to daytime bright light increase nocturnal melatonin rise and maintain circadian phase in young subjects under fixed sleep schedule

  Nana N. Takasu, Satoko Hashimoto, Yujiro Yamanaka, Yusuke Tanahashi, Ayano Yamazaki, Sato Honma, Ken-ichi Honma

  AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 291 (6) R1799 - R1807 0363-6119 2006/12 [Refereed][Not invited]
   

  Repeated exposures to daytime bright light increase nocturnal melatonin rise and maintain circadian phase in young subjects under fixed sleep schedule. Am J Physiol Regul Integr Comp Physiol 291: R1799-R1807, 2006. First published July 13, 2006; doi:10.1152/ajpregu.00211.2006.- Effects of two different light intensities during daytime were examined on human circadian rhythms in plasma melatonin, core body temperature, and wrist activity under a fixed sleep schedule. Sleep qualities as indicated by polysomnography and subjective sleepiness were also measured. In the first week, under dim light conditions (similar to 10 1x), the onset and peak of nocturnal melatonin rise were significantly delayed, whereas the end of melatonin rise was not changed. The peak level of melatonin rise was not affected. As a result, the width of nocturnal melatonin rise was significantly shortened. In the second week, under bright light conditions (similar to 5,000 1x), the phases of nocturnal melatonin rise were not changed further, but the peak level was significantly increased. Core body temperature at the initial sleep phase was progressively elevated during the course of dim light exposure and reached the maximum level at the first night of bright light conditions. Subjective sleepiness gradually declined in the course of dim light exposure and reached the minimum level at the first day of bright light. These findings indicate that repeated exposures to daytime bright light are effective in controlling the circadian phase and increasing the peak level of nocturnal melatonin rise in plasma and suggest a close correlation between phase-delay shifts of the onset of nocturnal melatonin rise or body temperature rhythm and daytime sleepiness.
• Effects of physical exercise on human circadian rhythms

  Yamanaka Yujiro, Honma Ken-ichi, Hashimoto Satoko, Takasu Nana, Miyazaki Toshihiko, Honma Sato

  Sleep and Biological Rhythms 4 (3) 199 - 206 2006/07 [Refereed][Not invited]
  
• Cardiovascular autonomic nervous response to postural change in 610 healthy Japanese subjects in relation to age

  Y Yamanaka, K Honma

  AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL 124 (1-2) 125 - 131 1566-0702 2006/01 [Refereed][Not invited]
   

  To determine the effect of aging on the cardiovascular response to postural change, we examined the cardiovascular sympathetic and parasympathetic response to active standing in 6 10 healthy Japanese subject (6-83 years) measuring the initial heart rate (HR) response for 3 min in the supine and standing position, we also measured the coefficient of variation of R-R interval (CVR-R). As a result, the cardiovascular response to active standing demonstrated a different change with aging between sympathetic rand parasympathetic. Sympathetic function was in a sthenia state in young subjects, and that this function declined with age increasing. Whereas, parasympathetic function was immature enough to inhibit the sympathetic tone in Young subjects and matured at 20 years of age, and had an ability to inhibit sympathetic tone. CVR-R show a linear change that decline with age increasing. These results indicated that the cardiovascular parasympathetic response to active standing shows a characteristic change with aging that differs from cardiovascular parasympathetic at rest represented by CVR-R. The present study is the first report to demonstrate the cardiovascular response to standing in relation to aging in large population. These results suggested that the cardiovascular response to postural change is dependent on subject's age. (c) 2006 Elsevier B.V. All rights reserved.
• ヒトサーカディアンリズム振幅に与える光の影響について

  高須 奈々, 橋本 聡子, 山仲 勇二郎, 本間 さと, 本間 研一

  日本生理学雑誌 (一社)日本生理学会 67 (12) 403 - 403 0031-9341 2005/12

Books etc

• 子どもの睡眠ガイドブック : 眠りの発達と睡眠障害の理解

  駒田, 陽子, 井上, 雄一 
  朝倉書店 2019 (ISBN: 9784254301199) viii, 173p
• 睡眠学I : 「眠り」の科学入門

  宮崎総一郎, 北浜邦夫, 井上昌次郎, 林光男, 山仲勇二郎, 松浦倫子 (Joint work第7章 生体リズムと睡眠)
  北大路書房 2018/11
• ヒトの生物時計制御と光環境

  山仲勇二郎 (Contributor第3章 光の情報利用)
  朝倉書店 2016/02 (ISBN: 9784254171617) 422 224-225
• 脳とこころのプライマリケア第5巻 意識と睡眠

  山仲勇二郎, 本間さと, 本間研一 (Contributor生物時計に関わる神経系)
  株式会社シナジー 2012/06 (ISBN: 9784916166296) 864 313-316
• 体内時計の科学と産業応用

  山仲勇二郎, 本間さと (Contributor体内時計の生理機能)
  シーエムシー出版 2011/05 (ISBN: 9784781303406) 253 11-19
• からだと温度の事典

  山仲勇二郎, 本間さと, 本間研一 (Contributor体温リズムの異常)
  朝倉書店 2010/04 (ISBN: 9784254301021) 640 139-142

Conference Activities & Talks

• 睡眠と体内時計  [Invited]

  山仲勇二郎

  第24回睡眠健康指導士上級講座  2020/11
• 知って得する「睡眠」のチカラ！  [Invited]

  山仲勇二郎

  令和2年度夕張市市民健康講座  2020/10
• 質の良い眠りとは～睡眠のウソ・ホント～  [Invited]

  山仲勇二郎

  令和2年度第2期えるのす連続講座～女性大学～  2020/09
• Effect of non-photic zeitgebers on circadian rhythm and sleep-wake cycle in humans  [Invited]

  山仲勇二郎, 橋本聡子, 本間あや, 本間さと, 本間研一

  第27回日本時間生物学会学術大会  2020/09
• 運動や食事が睡眠・生体リズムに与える影響  [Invited]

  山仲勇二郎

  第1回札幌睡眠フォーラム
• ぐっすり眠って健康に～すぐに実践できる睡眠改善法～  [Invited]

  山仲勇二郎

  佐呂間町働き盛り世代の健康づくり講演会
• Effect of mastication on glucose metabolism after high carbohydrate food consumption depends on the number of chew and time of day in healthy subjects  [Not invited]

  Yujiro Yamanaka, Arisa Sato, Yoshinori Ohtsuka

  第26回日本時間生物学会学術大会  2019/10
• Chronobiology: Circadian clock and circadian rhythms in humans  [Invited]

  Yujiro Yamanaka

  ILSI Japan第8回「栄養とエイジング」国際会議  2019/10
• ヒト生物時計の特性を考慮した生体リズム調整法と実践例  [Invited]

  山仲勇二郎, Jim Waterhouse

  第74回日本体力医学会大会  2019/09
• 社会的因子が生物時計と睡眠に与える影響～ヒト生物時計の2振動体モデルから睡眠に適した生活リズムを考える～  [Invited]

  山仲勇二郎

  第28回日本睡眠環境学会学術大会学術大会  2019/09
• 睡眠環境の重要性とアプリを用いた睡眠マネジメントの試み

  松浦倫子, 田中秀樹, 山仲勇二郎.

  第28回日本睡眠環境学会学術大会学術大会  2019/09
• 睡眠のウソ？ホント？ぐっすり眠るために大切なこと  [Invited]

  山仲勇二郎

  精神神経科学センター平成31年度学校訪問型睡眠講座事業
• 健康と深い関わりをもつ生物時計のふしぎ-すぐに実践できる生物時計の調整法を伝授します-  [Invited]

  山仲勇二郎

  第61回北大祭公開講義
• こころの健康に深く関わる睡眠・生体リズムの仕組み  [Invited]

  山仲勇二郎

  一般財団法人メンタルケア協会メンタルケア・スペシャリスト養成講座
• 生物時計の構造と機能～生体リズムの乱れが心身の健康に与える影響～  [Invited]

  山仲勇二郎

  日本東洋医学会北海道支部2019年度第1回教育講演会
• 生体リズムと健康の深い関わり  [Invited]

  山仲勇二郎

  全国保険協会（協会けんぽ）北海道支部と株式会社フィリップスの健康づくりの推進に向けた包括的相互連携に関する協定締結式
• 体内時計と健康のメカニズム  [Invited]

  山仲勇二郎

  北海道庁 平成30年度生活習慣病予防セミナー  2019/02
• 日の当たる朝で素敵な1日を  [Invited]

  山仲勇二郎

  北海道大学COI『食と健康の達人』拠点シンポジウム２０１８  2019/01
• 生物時計を考慮した健康的な生活リズムを デザインするための基盤研究  [Invited]

  山仲勇二郎

  2018年度日本生理学会北海道地方会総会  2018/12
• 生物時計を考慮した健康的な生活リズムをデザインするための基盤研究 ～From Laboratory to Field～  [Invited]

  山仲勇二郎

  2018年度第3回CEHS公開セミナー  2018/11
• 時間生物学を応用した効果的な運動・食事療法〜心リハへの適用の可能性を探る〜  [Invited]

  山仲勇二郎

  第3回日本心臓リハビリテーション学会北海道支部地方会  2018/11
• ヒト生物時計の調節機序と未解決問題  [Invited]

  山仲勇二郎

  ヒューマンカロリーメーター協議会  2018/11
• 光と運動による生体リズムの調節機序  [Invited]

  山仲勇二郎

  睡眠障害WEB Seminar  2018/11
• 生物時計を考慮した健康的な生活リズムをデザインするための基盤研究  [Not invited]

  山仲勇二郎

  第1回COI学会  2018/10
• Circadian rhythm of salivary cortisol is associated with the HPA axis activity in response to acute psychological stress in healthy subjects  [Not invited]

  山仲勇二郎, 元島英雅, 内田健冶

  第25回日本時間生物学会学術大会  2018/10
• Effect of seasonal changes in circadian rhythm on glucose metabolism under normal living condition in healthy young subjects  [Not invited]

  Chihiro Okuyama, Yujiro Yamanaka

  第25回日本時間生物学会学術大会  2018/10
• 健康に深く関わる生物時計の仕組み  [Invited]

  山仲勇二郎

  北大総合博物館主催土曜市民セミナー北大の研究最前線  2018/10
• 心理的ストレッサーに対するHPA axisストレス反応の概日リズム  [Not invited]

  山仲勇二郎

  第98回北海道医学大会生理系分科会  2018/10
• トップアスリートに知ってほしい睡眠・仮眠の正しい知識  [Invited]

  山仲勇二郎

  平成30年度ウィンタースポーツコンソシアム  2018/09
• ヒト生物時計の構造と機能  [Invited]

  山仲勇二郎

  2018年度日本生理人類学会夏期セミナー教育講演  2018/09
• からだにやさしいライフスタイル選択サポートの創造 －生物時計同調と快適睡眠で高める女子学生のＱＯＬ－  [Not invited]

  山仲勇二郎, 元池育子

  JSTフェア  2018/08
• 健康に深く関わる生物時計のふしぎ  [Invited]

  山仲勇二郎

  北海道大学教育学部公開講座2018  2018/08
• からだにやさしい ライフスタイル選択サポートの創造 －生物時計同調と快適睡眠で高める女子学生のＱＯＬ－  [Not invited]

  山仲勇二郎

  2018年度北海道大学COIサイトビジット  2018/07
• The role of physical exercise in the non-photic entrainment of the circadian system  [Not invited]

  Yujiro Yamanaka

  The 9th Congress of Asian Sleep Research Society（ASRS）  2018/07
• 睡眠は健康の宝物～質のよい眠りとは～  [Not invited]

  山仲勇二郎

  道新文化センター1Day講座  2018/04
• 生物時計を基盤にした健康支援システムの開発をめざして  [Invited]

  山仲勇二郎

  北大COI参画機関会議  2018/04
• ぐっすり眠って健康に～睡眠に深く関わる生物時計のふしぎ～  [Invited]

  山仲勇二郎

  ツルハドラッグ健康セミナー  2018/03
• 時間栄養学を活用した個人に適した食生活をデザインする  [Invited]

  山仲勇二郎

  平成29年度道民研修会 地域の食生活支援を推進するためのスキルアップ研修会  2018/03
• 生物時計を考慮した健康的な生活リズムをデザインするための基盤研究  [Invited]

  山仲勇二郎

  北大COIセミナー  2018/01
• 生物時計を考慮した健康的な生活リズムをデザインするための基盤研究  [Not invited]

  山仲勇二郎

  第3回COI2021ワークショップ  2017/11
• お母さんの生物時計と子供の生物時計のふしぎ  [Invited]

  山仲勇二郎

  北海道大学COI「食と健康の達人」拠点シンポジウム  2017/11
• 時間生物学から笑顔あふれす社会をめざして  [Invited]

  山仲勇二郎

  COI2021参画機関会議  2017/11
• 光環境と非光因子が睡眠・生物時計に与える影響～時間生物学からみた宇宙環境下での睡眠・生体リズム調整～  [Invited]

  山仲勇二郎

  第63回日本宇宙航空環境医学会  2017/11
• 時間生物学と生物時計の不思議  [Invited]

  山仲勇二郎

  平成29年度アクティブラーニング型学問探求セミナー  2017/11
• 睡眠と時間生物学  [Invited]

  山仲勇二郎

  第15回睡眠健康指導士上級講座  2017/11
• 双極性障害における概日リズムの内的脱同調  [Invited]

  山仲勇二郎

  第24回日本時間生物学会学術大会  2017/10
• 時間生物学入門～健康のために知っておきたい生物時計の仕組み～  [Invited]

  山仲勇二郎

  北大セミナーinオホーツク2017  2017/10
• A novel animal model for Jet lag syndrome  [Not invited]

  Yujiro Yamanaka

  ISSR 2017 conference  2017/09
• 1人1人の体内時計をつくる  [Not invited]

  山仲勇二郎

  COI2021 第2回ワークショップ  2017/09
• ねむり上手は健康上手～睡眠・生物時計のふしぎ～  [Invited]

  山仲勇二郎

  道薬検健康セミナー2017  2017/09
• 運動がヒト生物時計の光反応性に与える影響  [Invited]

  山仲勇二郎

  平成29年度(第50回)照明学会全国大会  2017/09
• 時間栄養学を実践するために知っておきたい生物時計のしくみ  [Invited]

  山仲勇二郎

  平成29年度中標津保健所管内栄養士会第1回研修会  2017/07
• 眠りと健康のふかーい関係～ぐっすり眠るためのコツを伝授します～  [Invited]

  Yujiro Yamanaka

  平成28年度鷹栖町健康づくり講演会  2017/03
• 時差対策のアップトゥデイト  [Invited]

  Yujiro Yamanaka

  第60回サッカードクターセミナー  2017/03
• 健康な毎日を送るために知っておきたい生物時計の仕組み  [Invited]

  Yujiro Yamanaka

  天使大学2016年度臨地実習に関わる講演会  2017/02
• Recent advancing the two oscillator model of circadian system in humans  [Invited]

  Yujiro Yamanaka, Satoko Hashimoto, Sato Honma, Ken-ichi Honma

  The 31th Sapporo Symposium on Biological Rhythms  2016/11
• ヒト生物時計の構造と概日リズム制御機構  [Invited]

  Yujiro Yamanaka

  第55回日本生気象学会大会  2016/11
• Exercise and circadian clock in humans  [Invited]

  Yujiro Yamanaka

  SICEライフエンジニアリング部門シンポジウム2016  2016/11
• Phase-adjustment of human circadian system by bright light and physical exercise  [Invited]

  Yujiro Yamanaka, Satoko Hashimoto, Sato Honma, Ken-ichi Honma

  The 29th ISC Conference in Suzhou, China  2016/10
• 生物時計の仕組みから子どもの健康を考える  [Invited]

  Yujiro Yamanaka

  第3回子どものからだと心・北海道研究会議  2016/10
• 生物時計と睡眠～生体リズムを調節し質のよい睡眠を～  [Invited]

  Yujiro Yamanaka

  第8回臨床睡眠医学学会サテライトシンポジウム  2016/08
• 時間生物学の基礎と体力医学へのメッセージ  [Invited]

  Yujiro Yamanaka

  第18回日本体力医学学会北海道地方会学術集会  2016/04
• 異なる照明条件下でのでの身体運動がヒト概日リズムの位相変化に与える影響  [Not invited]

  山仲勇二郎, 橋本聡子, 増渕悟, 夏堀晃世, 西出真也, 本間さと, 本間研一

  第20回日本時間生物学会学術大会  2013/11
• 高照度光下での身体運動がヒト概日リズムの位相調節に与える影響  [Not invited]

  山仲勇二郎, 橋本聡子, 増渕悟, 夏堀晃世, 西出真也, 本間さと, 本間研一

  第90回日本生理学会大会  2013/03
• 明暗周期位相変位後のマウス行動リズムを制御する視交叉上核領域振動体の探索  [Not invited]

  山仲勇二郎, 本間さと, 本間研一

  第19回日本時間生物学会学術大会  2012/09
• 1日1食の制限食事がヒトに給餌性リズムを発現させるか  [Not invited]

  本間研一, 山仲勇二郎, 橋本聡子, 本間さと

  第19回日本時間生物学会学術大会  2012/09
• 腕時計型行動計により計測されたヒト行動リズムから内的脱同調の有無を判断する  [Not invited]

  橋本聡子, 本間研一, 山仲勇二郎, 本間さと

  第19回日本時間生物学会学術大会  2012/09
• 母子同調因子としての環境温: in vivo における視交叉上核の温度感受性  [Not invited]

  吉川朋子, 松野亜美, 山仲勇二郎, 西出真也, 本間さと, 本間研一

  第19回日本時間生物学会学術大会  2012/09
• 時間隔離実験室を使用したヒト生物時計の非光同調機構の解析  [Not invited]

  山仲勇二郎, 橋本聡子, 高須奈々, 棚橋祐典, 西出真也, 本間さと, 本間研一

  第37回日本睡眠学会定期学術集会  2012/06
• 運動と生体リズム  [Not invited]

  山仲勇二郎, 橋本聡子, 増渕悟, 夏堀晃世, 西出真也, 本間さと, 本間研一

  第37回日本睡眠学会定期学術集会  2012/06
• How to measure human circadian rhythms  [Not invited]

  Yujiro Yamanaka, Satoko Hashimoto, Sato Honma, Ken-ichi Honma

  International Symposium and Workshop on Frontiers in Sleep and Biological Rhythms Research  2012/04
• 高照度光下での身体運動がヒト概日リズムの位相調節に与える影響  [Not invited]

  山仲勇二郎, 橋本聡子, 増渕悟, 夏堀晃世, 西出真也, 本間さと, 本間研一

  第89回日本生理学会大会  2012/03
• Effect of physical exercise on re-entrainment of human circadian rhythms to an 8 h advanced sleep schedule under bright light coditions  [Not invited]

  Yujiro Yamanaka, Satoko Hashimoto, Satoru Masubuchi, Akiyo Kameyama, Shin-ya Nishide, Sato Honma, Ken-ichi Honma

  International Symposium on Photic Bioimaging Satellite Symposium of Worldsleep 2011 on Human Circadian Clock- the 50th anniversary of temporal isolation study  2011/10
• Effect of scheduled physical exercise on re-entrainment of human circadian rhythms to an 8 h advanced sleep schedule in isolation facility  [Not invited]

  Yujiro Yamanaka, Satoko Hashimoto, Satoru Masubuchi, Akiyo Kameyama, Shin-ya Nishide, Sato Honma, Ken-ichi Honma

  WorldSleep 2011  2011/10
• 明暗周期位相シフト時のマウス行動リズムを制御する視交叉上核内領域振動体の探索  [Not invited]

  山仲勇二郎, 本間さと, 本間研一

  第34回神経科学学会  2011/09
• 明暗周期位相シフト後のマウス行動リズムと 視交叉上核領域内 mPeriod1 発現リズム  [Not invited]

  山仲勇二郎, 本間さと, 本間研一

  第91回北海道医学大会生理系分科会  2011/08
• The master and slave oscillators for behavioral rhythm in mice  [Invited]

  Yujiro Yamanaka, Sato Honma, Ken-ichi Honma

  The III World Congress of Chronobiology  2011/05
• 母子分離中の環境温度が新生ラットの概日リズムにおよぼす影響  [Not invited]

  吉川朋子, 松野亜美, 山仲勇二郎, 西出真也, 本間さと, 本間研一

  第17回日本時間生物学会学術大会  2010/11
• 時間隔離実験室を利用したヒト生物時計の構造解析. シンポジウム「体内時計制御工学を目指して」  [Invited]

  山仲勇二郎

  第17回日本時間生物学会学術大会  2010/11
• マウス末梢時計の8時間位相前進させた明暗周期への再同調は新奇環境暴露により促進される  [Not invited]

  山仲勇二郎, 本間さと, 本間研一

  第90回北海道医学大会生理系分科会・日本生理学会北海道地方会  2010/09
• 運動が生体リズムに与える影響. ワークショップ 生体リズムとスポーツパフォーマンス-基礎研究から現場へ  [Invited]

  山仲勇二郎

  第65回日本体力医学会大会  2010/09
• 明暗周期位相シフト後の新奇環境暴露によるマウス末梢時計の再同調促進効果に関する考察  [Not invited]

  山仲勇二郎, 本間さと, 本間研一

  第87回生理学会大会  2010/05
• 脱同調パラダイム実験によるヒト生物時計の構造解析  [Not invited]

  山仲勇二郎, 橋本聡子, 中村宏次, 本間さと, 本間研一

  日本睡眠学会第34回定期学術集会  2009/10
• ヒト生体リズムの非光再同調に与える 身体運動の影響  [Not invited]

  山仲勇二郎, 橋本聡子, 西出真也, 棚橋祐典, 本間さと, 本間研一

  第15回日本時間生物学会学術大会  2008/11
• 低照度環境下における強制的睡眠覚醒スケジュール時の身体運動が深部体温リズムおよび睡眠脳波に与える影響  [Not invited]

  山仲勇二郎, 橋本聡子, 本間さと, 本間研一

  H20年度体温研究会  2008/09
• Differential effects of scheduled novel environment with a running-wheel on re-entrainment of circadian clocks in the suprachiasmatic nuclei and peripheral tissues in mice subjected to an 8 h shifted light-dark cycles: implications for jet lag  [Not invited]

  Yujiro Yamanaka, Sato Honma, Ken-ichi Honma

  第85回日本生理学会  2008/03
• 8時間位相シフトさせた明暗周期に対するマウス行動リズムの再同調は新規環境暴露により促進される  [Not invited]

  山仲勇二郎, 本間さと, 本間研一

  第4回環境生理プレコングレス  2008/03
• Maturity process of cardiovascular autonomic function in resting supine position and response to postural change.  [Not invited]

  Yujiro Yamanaka, Koichi Honma

  5th Congress of the International Society for Autonomic Neuroscience: ISAN 2007  2007/10
• 脱同調パラダイムによるヒト生物時計の構造解析  [Not invited]

  山仲勇二郎

  第3回体温調節温度受容研究会  2007/09
• Four day physical exercise accelerates entrainment of human sleep-wake cycle but not of plasma melatonin rhythms to shifted sleep schedule under dim light condition.  [Not invited]

  Yujiro Yamanaka, Satoko Hashimoto, Yusuke Tanahashi, Shin-ya Nishide, Sato Honma, Ken-ichi Honma

  World Federation of Sleep Research and Sleep Medicine Society. 2007  2007/09
• Photic and non-photic entrainment of circadian behavioral rhythms in histamine decarboxylase knock out mice  [Not invited]

  Yujiro Yamanaka, Hiroshi Abe, Hiroshi Ohtsu, Sato Honma, Ken-ichi Honma

  第84回日本生理学会  2007/03
• 4日間の身体運動によるヒト生物時計の位相反応曲線の作成  [Not invited]

  山仲勇二郎, 橋本聡子, 高須奈々, 西出真也, 棚橋祐典, 本間さと, 本間研一

  第3回環境生理プレコングレス  2007/03
• 体温リズムの生物時計による内因性支配と非光同調因子による外因性修飾作用  [Not invited]

  山仲勇二郎, 橋本聡子, 高須奈々, 本間さと, 本間研一

  第2回体温調節温度受容研究会  2007/01
• 低照度環境下での身体運動が睡眠脳波、心臓自律神経活動に及ぼす影響  [Not invited]

  山仲勇二郎, 橋本聡子, 高須奈々, 本間さと, 本間研一

  日本睡眠学会第31回定期学術集会  2006/06
• Non-photic entrainment to scheduled 3-h wheel running in the mouse circadian rhythm  [Not invited]

  Yujiro Yamanaka, Hiroshi Abe, Sato Honma, Ken-ichi Honma

  第83回日本生理学会  2006/03
• 身体運動に対するヒト生物時計の位相反応性～位相反応曲線におけるCross over pointの同定～  [Not invited]

  山仲勇二郎, 橋本聡子, 高須奈々, 宮崎俊彦, 本間さと, 本間研一

  第2回環境生理学プレコングレス  2006/03
• Effects of exercise for circadian rhythm  [Invited]

  Yujiro Yamanaka, Ken-ichi Honma, Toshihiko Miyazaki, Satoko Hashimoto, Sato Honma

  World Federation of Sleep Research and Sleep Medicine Society 2005  2005/09
• 生体リズムと体温  [Not invited]

  山仲勇二郎, 高須奈々, 橋本聡子, 本間研一

  体温調節温度受容研究会  2005/09
• 体位変化に対する心血管系自律神経機能の加齢現象～起立時超早期脈拍変動による検討，新たな健常値の提言～  [Not invited]

  山仲勇二郎, 本間甲一

  第57回日本自律神経学会総会  2004/10

MISC

• 睡眠覚醒リズム障害の診断・治療につなげる概日リズムの基礎研究 日常生活下におけるヒト概日リズム測定法の検討

  山仲 勇二郎  日本睡眠学会定期学術集会・日本時間生物学会学術大会合同大会プログラム・抄録集  45回・30回-  131  -131  2023/09
• 試合開始時刻がプロ野球選手の夜間睡眠に及ぼす影響 ウェアラブルセンサーを用いた評価

  宮城 和, 松浦 倫子, 水島 仁, 横田 卓, 山仲 勇二郎  日本睡眠学会定期学術集会・日本時間生物学会学術大会合同大会プログラム・抄録集  45回・30回-  325  -325  2023/09
• 「研究成果を栄養教育に生かす」 食事時刻がヒトの概日リズム・糖代謝機能に与える影響

  山仲 勇二郎  日本栄養・食糧学会大会講演要旨集  77回-  167  -167  2023/03
• 【インスリン・糖尿病研究の新展開:基礎から臨床まで】糖代謝能にみられる概日リズムに対する咀嚼の効果

  山仲 勇二郎  日本薬理学雑誌  158-  (2)  165  -168  2023/03  

  生物時計は,バクテリアからヒトに至るまで地球上に生存するすべての生物が獲得した生存戦略である.哺乳類の生物時計機構は,脳内視床下部視交叉上核に存在する中枢時計と視交叉上核外の脳部位および全身の末梢組織に存在する末梢時計からなる階層性多振動体構造から構成される.生物時計の自律振動する分子メカニズムは,時計遺伝子とよばれる一群の遺伝子の転写と翻訳を介する自己制御型のネガティブフィードバックループである.時計遺伝子は,中枢時計である視交叉上核だけでなく末梢組織においても自律振動する概日リズムが確認されており,末梢組織の正常な生理機能との関連が明らかにされている.食後の血糖値上昇に対するインスリン分泌量にも概日リズムが観察される.経口糖負荷試験に対する耐糖能は,朝方に高く夜間に低くなる.耐糖能にみられる概日リズムは,睡眠および概日リズムの同調状態の影響を受けており,臨床においても血糖コントロールにおいても睡眠と概日リズムの調節が重要となる.国内では食事の際によく噛むことが健康にとって重要であることが指摘されている.著者らは,よく噛む=咀嚼の強化が食後の糖代謝能に与える影響が1日のなかで変化するかを健康な成人男子を対象に検討し,朝方の咀嚼の強化が食後のインスリン初期分泌を改善させる効果を持つことを報告した.本総説では,生物時計と糖代謝能,咀嚼の強化が糖代謝能の概日リズムに与える影響について解説する.(著者抄録)
• 「研究成果を栄養教育に生かす」 食事時刻がヒトの概日リズム・糖代謝機能に与える影響

  山仲 勇二郎  日本栄養・食糧学会大会講演要旨集  77回-  167  -167  2023/03
• そもそも睡眠とは何か?～睡眠の基礎研究の未来を多様な視点から論じる～ 睡眠覚醒リズム制御機構の解明にむけて 2プロセスモデルの限界と修正

  山仲 勇二郎  日本睡眠学会定期学術集会プログラム・抄録集  47回-  152  -152  2022/06
• 概日リズムのHuman Physiologyから迫る睡眠障害 時間隔離実験室を用いたヒト生物時計の構造と機能解析

  山仲 勇二郎, 本間 さと, 本間 研一  日本睡眠学会定期学術集会プログラム・抄録集  47回-  156  -156  2022/06
• LEDを用いた睡眠・概日リズムに優しい照明 ウェアラブル型光照射装置の開発と研究動向

  山仲 勇二郎, 久保田 直子, 馬場 謙吉, 田森 雄介  日本睡眠学会定期学術集会プログラム・抄録集  47回-  162  -162  2022/06
• 大学生における自己評価による健康状態に対するCOVID-19による学校の閉鎖の影響とその運動と睡眠との関係性(Impact of school closure due to COVID-19 on self-rated health status and its relationship between exercise and sleep in college students)

  久保田 直子, 松浦 倫子, 山仲 勇二郎  日本睡眠学会定期学術集会プログラム・抄録集  47回-  202  -202  2022/06
• 生物時計の基本性質と心身の健康との関わり

  山仲勇二郎  繊維製品消費科学  62-  (8)  2021
• Two-oscillator Model for Generating a Diurnal Change of Sleepiness: Ultradian Oscillator and the Circadian Oscillator

  田村聖, 松浦倫子, 北村航輝, 山仲勇二郎, 山仲勇二郎  生理心理学と精神生理学  39-  (1)  2021
• 時間栄養学を実践するために知っておきたいヒト生物時計の構造と機能

  山仲勇二郎, 山仲勇二郎  日本栄養・食糧学会大会講演要旨集  74th-  2020
• EFFECT OF SHORT DURATION-LOW INTENSITY EXERCISE BEFORE BEDTIME ON SLEEP AND MENTAL HEALTH

  山仲勇二郎  若手研究者のための健康科学研究助成成果報告書  (35)  2020
• Chronobiology: Human circadian pacemaker and circadian rhythms

  山仲勇二郎  体力科学  69-  (4)  2020
• Menstrual Phase-Dependency of Physiological Indices and Qualities of Life

  二口裕太, 元池育子, 元池育子, 山仲勇二郎, 辛島彰洋, 片山統裕, 中尾光之  電子情報通信学会技術研究報告(Web)  120-  (215(MBE2020 12-18))  2020
• Symposium14-4

  山仲勇二郎, Waterhouse Jim  体力科学  69-  (1)  63  -63  2020  [Not refereed][Not invited]
  
• 「生物時計」を一つのキーワードに働き方や暮らし方を考え、より健康的な生活を

  山仲勇二郎  看護職向け月刊誌『ベストナース』  2019/11  [Not refereed][Not invited]
  
• 【健康づくりのための時間栄養学】ヒト生物時計と生体リズムの調節機序

  山仲 勇二郎  体育の科学  69-  (11)  780  -787  2019/11  [Not refereed][Not invited]
  
• プレシジョンニュートリションで拓く健康の未来 時間生物学 生物時計と生体リズム(Future of Healthcare by Precision Nutrition Chronobiology: Biological Clock and Circadian Rhythms in Humans)

  山仲 勇二郎  イルシー  (140)  126  -129  2019/09  [Not refereed][Not invited]
  
• 【子どもの生活環境の変遷と生活習慣の実態】子どもにおける生物時計と生活リズム

  山仲 勇二郎  子どもと発育発達  17-  (1)  36  -41  2019/04  [Not refereed][Not invited]
  
• 【睡眠と医療】睡眠障害が身体に影響を及ぼすメカニズム

  山仲 勇二郎  月刊保団連  12-  (1283)  11  -17  2018/12  [Not refereed][Not invited]
  
• 【光環境と睡眠・概日リズム】 光環境と睡眠・概日リズムの基礎

  山仲 勇二郎  睡眠医療  11-  (4)  461  -471  2017/12  [Not refereed][Not invited]
   

  ヒトの行動(睡眠覚醒)、体温やホルモン分泌などの生理機能には24時間を1周期とするリズム(概日リズム)があり、脳内の生物時計により発振される。生物時計は、地球の自転により生じる24時間周期の環境周期に同調(外的同調)し、昼行性動物であるヒトが昼間に十分活動し、夜間に質のよい睡眠をとれるように行動および生理機能を時間的に統合している(内的同調)。ヒトの生物時計は、明暗サイクル(高照度光)を同調因子として、深部体温やメラトニンリズムを制御する振動体(視交叉上核に局在)と生活スケジュールや運動といった社会的因子を同調因子として睡眠覚醒リズムを制御する振動体(視交叉上核外脳部位に局在)からなる2振動体モデルが想定されている。良質な睡眠を確保するには、生物時計の外的・内的同調を維持するとともに、生物時計および睡眠にかかわる生理機能(メラトニン、深部体温)に影響する光環境を調整することが必要となる。(著者抄録)
• アクチグラフィを用いた双極性障害患者における概日リズム障害の検討

  北川 寛, 北市 雄士, 中川 伸, 宇土 仁木, 若槻 百美, 亀山 梨絵, 仲唐 安哉, 山仲 勇二郎, 本間 さと, 本間 研一, 井上 猛, 久住 一郎  日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集  47th-  188  -188  2017  [Not refereed][Not invited]
  
• 光環境と睡眠・概日リズムの基礎

  山仲勇二郎  睡眠医療  11-  (4)  401  -411  2017  [Not refereed][Not invited]
  
• 時間生物学の基礎と体力医学へのメッセージ

  山仲 勇二郎  体力科学  65-  (6)  541  -541  2016/12  [Not refereed][Not invited]
  
• 【糖尿病・うつ・睡眠障害による負のトライアングル】 睡眠障害・うつの糖尿病・身体疾患に及ぼす影響 睡眠障害が糖代謝に与える影響とそのメカニズム

  山仲 勇二郎, 本間 研一  月刊糖尿病  8-  (11)  74  -81  2016/11  [Not refereed][Not invited]
  
• 睡眠障害が糖代謝に与える影響とそのメカニズム

  山仲勇二郎, 本間研一  月刊糖尿病  8-  (11)  74  -81  2016/10/20  [Not refereed][Invited]
  
• ヒト生物時計の構造と概日リズム制御機構

  山仲 勇二郎  日本生気象学会雑誌  53-  (3)  S15  -S15  2016/10  [Not refereed][Not invited]
  
• 生活環境と生物時計

  山仲勇二郎  日本生気象学会雑誌  53-  (2)  69  -81  2016/08/08  [Not refereed][Invited]
  
• 双極性障害における概日リズム異常の経時的評価

  山仲 勇二郎, 北市 雄士, 北川 寛, 井上 猛, 本間 さと, 本間 研一  日本生理学雑誌  78-  (4)  67  -67  2016/07  [Not refereed][Not invited]
  
• 生活環境と生物時計

  山仲 勇二郎  日本生気象学会雑誌  53-  (2)  69  -81  2016/07  [Not refereed][Not invited]
   

  私たちの行動(睡眠覚醒)、血圧、ホルモン分泌などの生理機能を長時間にわたり観察すると明瞭な24時間リズム(概日リズム)がみられる。概日リズムの発振源は、内因性の自律振動機構である生物時計である。ヒトを含め哺乳類の生物時計は、視床下部の視交叉上核に存在する中枢時計と肝臓、肺、心臓など全身の末梢組織に存在する末梢時計からなる階層構造をもつ。生物時計の役割は、外部環境への同調と生理機能を時間的に統合することであり、ヒトが昼間に活動し夜間に睡眠をとるのに最適な体内環境を整えている。しかし、生活環境および生活リズムが多様化した現代においては、生物時計の支配に逆らった生活を余儀なくされるものも少なくない。睡眠や生体リズムの不安定化は、エネルギー代謝障害や気分障害等と関連することが報告されている。本論では、ヒトの生物時計の基本性質について解説すると共に、光環境、食習慣、運動習慣といった生活環境が生物時計に与える影響について紹介する。(著者抄録)
• 若年の心自律神経機能の推移と機能性脳循環疾患 起立時超早期脈拍変動による検討

  本間 甲一, 赤荻 悠一, 島田 潤一郎, 仲野 義和, 橋本 憲一郎, 松田 信二, 山仲 勇二郎  臨床神経学  55-  (Suppl.)  S227  -S227  2015/12  [Not refereed][Not invited]
  
• 気分障害と概日リズム 位相前進仮説から時計遺伝子変異へ 双極性障害における概日リズム障害 時計遺伝子レポーターによる解析

  本間 さと, 山仲 勇二郎, 夏堀 晃世, 吉川 朋子, 井上 猛, 本間 研一  日本うつ病学会総会・日本認知療法学会プログラム・抄録集  12回・15回-  129  -129  2015/07  [Not refereed][Not invited]
  
• 運動と睡眠 再検討 光と運動によるヒト生物時計の調節メカニズム

  山仲 勇二郎, 橋本 聡子, 高須 奈々, 増渕 悟, 夏堀 晃世, 棚橋 祐典, 西出 真也, 本間 さと, 本間 研一  日本睡眠学会定期学術集会プログラム・抄録集  40回-  136  -136  2015/07  [Not refereed][Not invited]
  
• ヒトを対象とした時間生物学研究に魅せられて

  山仲勇二郎  時間生物学  21-  (1)  2  -9  2015/06/30  [Not refereed][Invited]
  
• 高照度光下での運動が生体リズムおよび睡眠に与える影響

  山仲 勇二郎, 橋本 聡子, 増渕 悟, 夏堀 晃世, 西出 真也, 本間 さと, 本間 研一  体力科学  64-  (3)  385  -385  2015/06  [Not refereed][Not invited]
  
• 高照度光下での身体運動は8時間位相前進シフトした生活スケジュールへの血中メラトニンリズムの再同調を促進する

  山仲 勇二郎, 橋本 聡子, 増渕 悟, 夏堀 晃世, 西出 真也, 本間 さと, 本間 研一  日本睡眠学会定期学術集会プログラム・抄録集  38回-  179  -179  2013/06  [Not refereed][Not invited]
  
• Effects of timed physical exercise on phase shifts of human circadian rhythms induced by 8-h advance shift of sleep schedule under bright light conditions

  Yujiro Yamanaka, Satoko Hashimoto, Satoru Masubuchi, Akiyo Natsubori, Shin-ya Nishide, Sato Honma, Ken-ichi Honma  JOURNAL OF PHYSIOLOGICAL SCIENCES  63-  S259  -S259  2013  [Not refereed][Not invited]
  
• 次世代の睡眠基礎研究 時間隔離実験室を使用したヒト生物時計の非光同調機構の解析

  山仲 勇二郎  日本睡眠学会定期学術集会プログラム・抄録集  37回-  114  -114  2012/06  [Not refereed][Not invited]
  
• 身体運動と睡眠 運動と生体リズム

  山仲 勇二郎  日本睡眠学会定期学術集会プログラム・抄録集  37回-  120  -120  2012/06  [Not refereed][Not invited]
  
• Regional oscillators in the mouse suprachiasmatic nucleus involved in the compression of circadian behavioral rhythms after an 8 h advance shift of light-dark cycles

  Yujiro Yamanaka, Sato Honma, Ken-ichi Honma  NEUROSCIENCE RESEARCH  71-  E172  -E172  2011  [Not refereed][Not invited]
  
• 睡眠障害が身体に影響を及ぼすメカニズム (特集 睡眠障害治療により期待される身体疾患の改善)

  山仲 勇二郎, 本間 さと, 本間 研一  ねむりと医療  3-  (2)  65  -71  2010/12
• 睡眠障害が身体に及ぼすメカニズム

  山仲勇二郎, 本間さと, 本間研一  ねむりと医療  3-  (2)  1  -7  2010/12  [Not refereed][Not invited]
  
• Acceleration of photic entrainment by non-photic time cues in mouse: effects of exercise and/or stress on central and peripheral clocks

  Yujiro Yamanaka, Sato Honma, Ken-ichi Honma  JOURNAL OF PHYSIOLOGICAL SCIENCES  60-  S100  -S100  2010  [Not refereed][Not invited]
  
• Daily phase adjustment of human sleep-wake cycle

  山仲勇二郎, 本間さと, 本間研一  Japanese journal of clinical medicine  67-  (8)  1475  -1482  2009/08  [Not refereed][Not invited]
  
• 時差症候群・交代勤務睡眠障害のバイオロジー (特集 産業社会と睡眠)

  山仲勇二郎, 橋本聡子, 本間さと  睡眠医療  3-  (3)  379  -382  2009/08  [Not refereed][Not invited]
  
• 睡眠障害の時間治療 (特集 時間薬理学--最適な投与方法を求めて)

  山仲勇二郎, 本間さと, 本間研一  医薬ジャ-ナル  45-  (6)  107  -112  2009/06  [Not refereed][Not invited]
  
• EFFECTS OF AMBIENT TEMPERATURE DURING MATERNAL DEPRIVATION ON CIRCADIAN RHYTHMS OF NEONATAL RATS

  Tomoko Yoshikawa, Ami Matsuno, Yujiro Yamanaka, Sin-ya Nishide, Sato Honma, Ken-ichi Honma  JOURNAL OF PHYSIOLOGICAL SCIENCES  59-  535  -535  2009  [Not refereed][Not invited]
  
• RE-ENTRAINMENT OF CIRCADIAN RHYTHMS AFTER 8 H ADVANCED LIGHT-DARK CYCLES DEPENDS ON THE TIMING OF EXPOSURES TO NOVEL ENVIRONMENT IN MICE

  Yujiro Yamanaka, Sato Honma, Ken-ichi Honma  JOURNAL OF PHYSIOLOGICAL SCIENCES  59-  535  -535  2009  [Not refereed][Not invited]
  
• ヒト血中メラトニンリズムに与える光照度の影響について

  高須奈々, 橋本聡子, 山仲勇二郎, 本間さと, 棚橋祐典, 山崎綾野, 西出真也, 野田なつみ, 本間研一  時間生物学  11-  (2)  2005
• 起立時超早期脈拍変動検査による神経調節性失神と起立性頻拍症候群の心血管系障害の機序と治療

  本間 甲一, 山仲 勇二郎, 山本 達也, 小野寺 正和, 松田 信二  神経治療学  21-  (3)  311  -311  2004/05  [Not refereed][Not invited]
  
• 高齢者における登山時の自律神経機能

  山仲勇二郎, 渡辺剛, 永吉英記  国士館大学体育研究所報  21-  27  -34  2002  [Not refereed][Not invited]
  
• 報告書(体育研究所プロジェクト研究)環境変化と心臓自律神経活動との関連

  永吉英記, 渡辺剛, 山仲勇二郎  国士館大学体育研究所報  21-  141  -144  2002  [Not refereed][Not invited]
  
• 092 総合体育館 08 キャンプ生活がサーカディアンリズムに与える影響

  永吉 英記, 渡辺 剛, 川村 協平, 山田 亮, 山仲 勇二郎  日本体育学会大会号  53-  (0)  511  -511  2002  [Not refereed][Not invited]
  

Industrial Property Rights

• 特開2023-011076:光照射装置  2023/01/24

  田森 雄介, 山口 悦範, 山仲 勇二郎  電制コムテック株式会社, 国立大学法人北海道大学  202303020171919238
• 特許第7198460号:光照射装置  

  田森 雄介, 山口 悦範, 山仲 勇二郎  電制コムテック株式会社, 国立大学法人北海道大学  202303003030232482
• 特許7198460:光照射装置  

Awards & Honors

• 2023/08 北海道大学 北海道大学全学教育科目授業アンケートにおけるエクセレント・ティーチャーズ
  
• 2022/08 北海道大学 北海道大学全学教育科目授業アンケートにおけるエクセレント・ティーチャーズ
  
• 2021/08 北海道大学 全学教育科目に係る授業アンケートにおけるエクセレントティーチャーズ
  
• 2019/10 日本神経精神薬理学会 Neuropsychopharmacology Reports (NPPR) Topic Award 2019
   

  受賞者: 山仲勇二郎
• 2019/10 日本神経精神薬理学会 Neuropsychopharmacology Reports (NPPR) Article Award 2019
   

  受賞者: 山仲勇二郎
• 2017/11 国立研究開発法人 科学技術振興機構（JST) COI2021 表彰特別賞
   

  受賞者: 山仲勇二郎
• 2015/07 北海道大学医学部医学科 平成26年度エクセレント・ティーチャー(優秀賞）
   

  受賞者: 山仲勇二郎
• 2014/11 日本時間生物学学会 日本時間生物学会学術奨励賞
   

  受賞者: 山仲勇二郎
• 2014/07 北海道大学医学部医学科 平成25年度優秀教員賞
   

  受賞者: 山仲勇二郎
• 2013/11 第20回日本時間生物学会学術大会優秀ポスター賞
   

  受賞者: 山仲勇二郎
• 2012/03 日本生理学会環境生理学グループ久野寧記念賞
   

  受賞者: 山仲勇二郎

Research Grants & Projects

• Understanding of sleep-wake regulatory mechanisms in nature

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

  Date (from‐to) : 2020/10 -2024/03 

  Author : 小野 大輔, 池上 啓介, 山仲 勇二郎

   

  睡眠・覚醒や体温調節など、ほぼすべての生理機能には２４時間を１サイクルとする“概日リズム”が存在し、“概日時計”がその時間的調節を担う。我々の身体を構成する すべての細胞に、概日時計は備わり、時計遺伝子の転写・翻訳を介したフィードバックループがその中心的役割を示す。概日時計の中でも、中枢時計である「視交叉上核」はペースメーカーとして機能し、睡眠・覚醒のリズムを調節する。
  近年の光遺伝学の技術開発により、様々な生命現象を調節する神経回路が同定されてきている。哺乳類の睡眠研究においても、実験室の飼育環境下における睡眠・覚醒調節に関わる神経細胞が同定されてきた。一方、自然界における動物の睡眠研究はほとんどなされていない。しかし、最近になって自然界における睡眠・覚醒パターンが、実験室の結果とは大きく異なる事が示唆されてきた。国際生物学賞を受賞したDr. S. Daan（故）は、自然条件下（野外）でマウスを飼育すると、夜行性から昼行性にシフトする事を発見した。本研究では、自然環境下における動物行動の調節を担う神経メカニズムの解明を行う。
• Mechanism of exercise effect on the central circadian pacemaker

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

  Date (from‐to) : 2019/04 -2024/03 

  Author : 山仲 勇二郎

   

  本研究では雄性のC57BL/6-Tg(Period1-luc)マウスを用いて、マウスの自発活動リズムが①LD12:12明暗サイクルに同調、②恒常暗下でフリーラン、③恒常暗下で1日3時間の回転輪のついた新しいケージに移す新奇環境暴露スケジュールに同調、の3条件下で視交叉上核、弓状核、肝臓、骨格筋を採取し、生物発光測定装置を用いてPer1-lucリズムを測定した。各組織における培養翌日のPer1-lucリズムのピーク位相をリズム指標として、行動リズムの活動開始・終了位相および中枢・末梢時計間の位相関係を解析した。その結果、明暗サイクル同調時と新奇環境暴露スケジュール同調時におけるSCNのPer1-lucリズムのピーク位相はいずれも主観的明期(マウスの休息期)にみられた。肝臓および骨格筋のピーク位相は、主観的暗期(マウスの活動期)にみられた。行動リズム位相とSCN、肝臓、骨格筋のPer1-lucリズムの位相関係は明暗サイクル下と新規環境暴露スケジュール同調時で有意な差は認められなかった。一方、弓状核のPer1-lucリズム、明暗サイクル下および恒常暗でのフリーラン条件下では主観的暗期にピーク位相がみられたが、新奇環境暴露同調時に明暗サイクルおよび恒常暗条件に比べ、有意に位相前進し主観的明期にピーク位相がみられた。本研究により、恒常暗下での習慣的な運動スケジュールがマウスSCNの同調因子として作用し、明暗サイクル同調時におけるSCNと行動リズム、肝臓、骨格筋の末梢時計間の位相関係を維持した状態で同調することを明らかにした。
• 光と運動による生物時計調節メカニズムの解明：運動による効果的な生体リズム調整法の開発を目指して

  公益財団法人 ヤマハ発動機スポーツ振興財団：

  Date (from‐to) : 2020/04 -2021/03 

  Author : 山仲勇二郎
• 就寝前の低強度短時間運動が睡眠・メンタルヘルスに及ぼす影響

  公益財団法人明治安田厚生事業団：公益財団法人明治安田厚生事業団若手研究者のための健康科学研究助成第35回助成金〈一般〉

  Date (from‐to) : 2018/10 -2020/02 

  Author : 山仲勇二郎
• 糖代謝能の概日リズムと咀嚼運動に注目した新たな栄養食事指導法の提言

  公益財団法人秋山生命科学振興財団：公益財団法人秋山生命科学振興財団－2018年度研究助成〈一般〉－

  Date (from‐to) : 2018/07 -2019/03 

  Author : 山仲勇二郎
• からだにやさしいライフスタイル選択サポートの創造－生物時計同調と快適睡眠で高める女子学生のＱＯＬ－

  国立研究開発法人科学技術振興機構：センター・オブ・イノベーションプログラム COI若手連携研究ファンド 平成30年度連携研究

  Date (from‐to) : 2018/04 -2019/03 

  Author : 山仲勇二郎
• 光と運動による生体リズムの調節メカニズム

  文部科学省：科学研究費補助金(基盤研究Ｃ)

  Date (from‐to) : 2016/04 -2019/03 

  Author : 山仲勇二郎
• 高照度光下での運動が生物時計の光反応性に与える影響

  睡眠健康推進機構：平成28年度睡眠健康推進機構学術研究助成

  Date (from‐to) : 2016/10 -2018/03 

  Author : 山仲勇二郎
• 運動時の照明条件が睡眠・生体リズムに与える影響

  一般社団法人照明学会：第25回一般社団法人照明学会研究・教育助成 (奨励研究)

  Date (from‐to) : 2016/07 -2017/03 

  Author : 山仲勇二郎
• 脳ペプチドダイアリシス法を応用した生物時計からの液性出力因子による概日リズム調節メカニズムの解明

  公益信託 成茂神経科学研究助成基金：平成27年度 公益信託 成茂神経科学研究助成基金

  Date (from‐to) : 2015/07 -2016/03 

  Author : 山仲勇二郎
• Novel peptide-dialysis system to assess the effect of physical exercise on the circadian clock

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2013 -2015 

  Author : Yamanaka Yujiro

   

  Brain microdialysis is a powerful technique for measuring a neurotransmitter in extracellular fluid from free moving animals. By using this technique with some modification for measuring a large molecule (neuropeptide), we examined circadian rhythm of neuropeptide released from a central circadian pacemaker of suprachiasmatic nucleus in free moving mice. The mice were placed under a normal light-dark cycle and constant darkness conditions for 2-4 days. During this period, artificial cerebrospinal fluid was perfused at a flow rate of 1 μl/min and the dialysate were collected every 1 h. As a result, circadian rhythm of AVP in dialysate was detected in some mice that the dialysis probe was inserted close to the SCN. The highest value was observed in early subjective day (ZT4). However, in other mice, circadian rhythms of AVP in dialysate were not detected. Technical improvement would be needed in future studies.
• 食事時刻がヒトの生体リズムおよびエネルギー代謝調節に与える影響

  公益財団法人 石本記念デサントスポーツ科学振興財団：公益財団法人 石本記念デサントスポーツ科学振興財団 第36回研究助成

  Date (from‐to) : 2014/06 -2014/11 

  Author : 山仲勇二郎
• Food entrainable circadian rhythm in humans

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

  Date (from‐to) : 2011/04 -2014/03 

  Author : HONMA Ken-ichi, NISHIDE Shin-ya, YAMANAKA Yujiro, HASHIMOTO Satoko

   

  Appearance of premeal anticipatory hormone peak and entrainability of restricted meal schedule were examined in humans who stayed in a temporal isolation facility without knowing the time of day. Meal was supplied once a day for 10 days. As a result, the premeal peak was not detected in plasma melatonin, cortisol, insulin, ghrelin, and leptin. On the other hand, the sleep-wake cycle was entrained by the meal schedule, whereas the circadian melatonin rhythm was not entrained showing phase-delay shifts. These findings indicated that the so-called food entrainable circadian rhythm failed to appear in humans under the present conditions, and that the meal schedule was the time cue for the sleep-wake cycle but not for the circadian pacemaker.
• 食事制限がヒトの生体リズムおよびエネルギー代謝調節に与える影響

  公益財団法人サッポロ生物科学振興財団：公益財団法人サッポロ生物科学振興財団 第1回研究助成

  Date (from‐to) : 2012/06 -2013/04 

  Author : 山仲勇二郎
• 身体運動による生体リズム調節法の開発

  文部科学省：科学研究費補助金(若手研究(B))

  Date (from‐to) : 2011 -2012 

  Author : 山仲 勇二郎

   

  (研究の目的)本研究は、ヒト生物時計に対する高照度光と身体運動の相互作用を時間隔離実験室を使用し、行動（睡眠覚醒）、ホルモン（メラトニン）、深部体温のリズムを測定し検証する。(実施計画)本研究は、健康な20代の成人男性を対象に時間隔離実験室を使用して行う。被験者は、時間隔離実験室内で12泊13日生活する。実験は、通常のリズム位相を測定するベースライン期間(3日)、通常の睡眠時間帯を8時間位相前進する強制スケジュール期間(4日)、そして、睡眠時間や食事のタイミングを制限しないフリーラン期間(6日)、3つのセッションからなる。ベースラインおよび強制スケジュール期間中は8時間睡眠、16時間覚醒とし、覚醒時の実験室内の照度は約3000ルクスの高照度光とし、睡眠中は約0ルクスである。メラトニンリズムを計測するための採血時およびフリーラン期間中は約10ルクスの低照度に設定する。(研究実績)平成23年度の研究計画に従い、3回の隔離実験を行い、対照群4名、運動群4名より以下の結果を得た。[睡眠覚醒リズム]対照群（4名中3名）、運動群（4名）ともにフリーラン第1日目の睡眠開始位相は8時間前進した就寝時刻付近にみられ睡眠覚醒リズムは身体運動を負荷しなくとも高照度光のみで再同調が完了していた。[メラトニリズム]対照群、運動群ともに8時間前進スケジュール最終日ではベースライン期間から5～6時間の位相前進が認められた。メラトニンリズムの位相前進量は、対照群と運動群間では同程度であり、運動によるメラトニンリズムの再同調促進効果は認められなかった。
• Synchronization effects of physical exercise on human peripheral clocks regulating behavior rhythms

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

  Date (from‐to) : 2009 -2011 

  Author : HASHIMOTO Satoko, TANAHASHI Yuhsuke, YAMANAKA Yujiro

   

  To clarify whether physical exercise is a time cue for the human circadian clock and the mechanism by which physical exercise entrains the clock, we performed a series of experiment under temporal isolation using an 8h phase-advanced desynchrony protocol. Adult female subjects were required to perfome physical exercise of 2 hour duration twice a day using bicycle ergometer. The circadian rhythms in plasma melatonin and deep body temperature, which are believed to be regulated by the central circadian pacemaker, were measured simultaneously with the sleep-wake cycle which is thought to be driven by the peripheral clock. As a result, the re-entrainment of the sleep-wake cycle to a 8 h phase-advanced schedule was accelerated by timed physical exercise under dim light of ca. 10 lx, whereas the plasma melatonin did not phase-advance regardless of timed physical exercise. On the other hand, the re-entrainment of the sleep-wake cycle was accomplished regardless of timed physical exercise under bright light of ca. 5,000 lx, whereas the plasma melatonin rhythm phase-advanced but did not fully entrain but phase-advanced with or without timed physical exercise. The findings indicate that time physical exercise has a potency to entrain the sleep-wake cycle, but the effect is masked under bright light conditions.
• Acceleration mechanism of re-entrainment of circadian rhythms by physical exercise in mammals

  Ministry of Education, Culture, Sports, Science and Technology：Grants-in-Aid for Scientific Research(若手研究(B))

  Date (from‐to) : 2009 -2010 

  Author : yujiro YAMANAKA

   

  The aim of present study was to clarify acceleration mechanism of re-entrainment of circadian behavioral and clock gene expression rhythm in peripheral tissues (peripheral clocks) to a large shift of light-dark cycle (e.g. jet-lag travel in humans) by physical exercise in mammals. We could demonstrate that the effect of physical exercise, such as exposure to new cage with a running-wheel, on the re-entrainment of peripheral clock was dependent on the timing of exposure. During the transient days in behavior after shift of light cycle, circadian clock gene expression rhythm in the central clock in the suprachiasmatic nucleus (SCN) showed a regional difference in the waveforms and phases. These finding addresses a new hypothesis that the scheduled physical exercise directly affect on the regional oscillator in the SCN. If so, it leads to increase a coupling strength between the SCN and peripheral clock and to accelerate re-entrainment of peripheral clocks by physical exercise.
• Analysis of multi-oscillator structure of biological clock

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)

  Date (from‐to) : 2008 -2010 

  Author : HONMA Ken-Ichi, TANAHASHI Yuhsuke, NISHIDE Shinya, NAKAMUEA Tomoko, YAMADA Yoshiko, YASUDA Tsubura, SHUDO Miwako, YAMANAKA Yuhjiro, HASHIMOTO Satoko, TOKUMARU Nobuko

   

  Oscillating neurons in the suprachiasmatic nucleus (SCN), the center of biological clock, constructs more than one regional pacemakers of different characteristics through mutual synchronization. The roles of regional pacemakers depend on the area of SCN, and their interaction determines the length of activity period, showing seasonal changes in behavioral rhythms. The function of biological clock is disrupted by restricted daily feeding or methamphetamine treatment, which is supposed to be due to desynchronization between the central and peripheral clocks. The peripheral clock(s) regulating behavioral rhythms is suggested to reside in the midbrain.

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• 生物時計から見た健康的な食習慣

  Date : 2021/01

  Writer: Myself

  Publisher, broadcasting station: キューピー株式会社

  Program, newspaper magazine: キューピーニュース

  キューピーニュース. 561, 2021.1.28 Pr
• 正しい睡眠で免疫力アップ

  Date : 2020/06

  Writer: Myself

  Publisher, broadcasting station: 北海道文化放送UHB

  Program, newspaper magazine: みんテレ

  Media report
• 休校で崩れる生活リズム 心身の健康悪化も 体内時計整える習慣を

  Date : 2020/05

  Publisher, broadcasting station: NHKさっぽろ

  Program, newspaper magazine: 北海道のニュース

  Media report
• 美と若さの新常識～カラダのヒミツ～

  Date : 2020/04/16

  Publisher, broadcasting station: NHK

  Program, newspaper magazine: NHK BSプレミアム

  ダイエットの前に体内時計お直し術 Media report
• 聞きたい新型コロナウイルス 生活リズム整え健康維持

  Date : 2020/04

  Publisher, broadcasting station: 北海道新聞

  Program, newspaper magazine: 北海道新聞

  Paper
• 「よく噛んで食事をする」と食後の血糖上昇を抑えられる 「よく噛む」食事法は朝と夜で効果に差が

  Date : 2019/12/11

  Publisher, broadcasting station: 日本医療・健康情報研究所／創新社

  Program, newspaper magazine: 保健指導リソースガイド

  Internet
• 朝の食事 1口40回かむと「血糖値下げる効果」

  Date : 2019/12/06

  Writer: Other than myself

  Program, newspaper magazine: 読売新聞

  Paper
• 咀嚼が食後血糖値を下げる効果は朝と夜で異なる 朝に咀嚼回数を増やすと最も効果的 インスリン初期分泌を促進

  Date : 2019/11/29

  Publisher, broadcasting station: 糖尿病治療研究会 公益財団法人 日本糖尿病財団 日本医療・健康情報研究所

  Program, newspaper magazine: 糖尿病リソースガイド

  Internet
• Your body may not cope with evening stress: Study

  Date : 2019/11/28

  Writer: Other than myself

  Publisher, broadcasting station: Business Standard

  Internet
• Your body may not cope with evening stress: Study

  Date : 2019/11/28

  Writer: Other than myself

  Publisher, broadcasting station: Can-India News a division of World Media Corp (Canada) Inc

  Internet
• Beware of evening stress

  Date : 2019/11/27

  Publisher, broadcasting station: Science Daily

  Internet
• Beware of evening stress

  Date : 2019/11/27

  Writer: Other than myself

  Publisher, broadcasting station: Medical Press

  Internet
• Beware of Evening Stress

  Date : 2019/11/27

  Publisher, broadcasting station: Technology Networks Ltd

  Internet
• 朝食かむほど血糖値低下 白米１０回→４０回で最大１４％ 北大など研究

  Date : 2019/11/27

  Writer: Other than myself

  Program, newspaper magazine: 北海道新聞

  Paper
• 朝方の咀嚼運動の強化で、食後の血糖値が速やかに低下－北大ほか

  Date : 2019/11/26

  Publisher, broadcasting station: 株式会社QLife

  Program, newspaper magazine: 医療NEWS QLifePro

  Internet
• 【スポーツの力】未来をつくる＜４＞光と運動 快眠の解』

  Date : 2019/11/11

  Writer: Other than myself

  Program, newspaper magazine: 読売新聞

  Paper
• あなたの睡眠、間違いかも！眠りの常識ウソ・ホント

  Date : 2019/09/02

  Publisher, broadcasting station: STV

  Program, newspaper magazine: どさんこワイド179

  Media report
• The Health Risks of Evening Stress

  Date : 2019/07/26

  Writer: Other than myself

  Publisher, broadcasting station: Medium US

  Internet
• Stressresistent am Abend

  Date : 2019/02/05

  Writer: Other than myself

  Publisher, broadcasting station: Spektrum.de

  Internet
• How to plan your day to get the best out of your brain

  Date : 2019/02/01

  Publisher, broadcasting station: BBC News

  Internet
• Beware of stressful events in the evening

  Date : 2018/12/24

  Writer: Other than myself

  Publisher, broadcasting station: Health Day

  Internet
• Beware of Stressful Events in the Evening

  Date : 2018/12/17

  Writer: Other than myself

  Publisher, broadcasting station: MedicineNet

  Internet
• Stress in the evening harder on body than at other times: study

  Date : 2018/12/15

  Writer: Other than myself

  Publisher, broadcasting station: United Press International, Inc.

  Internet
• Beware of Stressful Events in the Evening

  Date : 2018/12/14

  Writer: Other than myself

  Publisher, broadcasting station: Doctors Lounge

  Internet
• Beware of Stressful Events in the Evening

  Date : 2018/12/14

  Publisher, broadcasting station: U.S.News

  Internet
• 「ストレス反応」は朝と夜で異なる 体内時計をストレスマネジメントに応用

  Date : 2018/12/10

  Publisher, broadcasting station: 一般社団法人日本生活習慣病予防協会

  Internet
• 夜はリラックスタイムではない！？ストレス防御機能が低下 北大がホルモン変化確認

  Date : 2018/12/05

  Program, newspaper magazine: 日刊工業新聞

  Paper
• Estar stressado à tarde é mais perigoso do que de manhã

  Date : 2018/12/03

  Writer: Other than myself

  Publisher, broadcasting station: ZAP

  Internet
• Beware getting too stressed in the evening

  Date : 2018/12/02

  Writer: Other than myself

  Publisher, broadcasting station: DIGITAL JOURNAL

  Internet
• ストレスからの防御は夜は弱い

  Date : 2018/12

  Publisher, broadcasting station: NHK さっぽろ

  Program, newspaper magazine: NHK 北海道のニュース

  Media report
• Feeling Stressed At Night Takes A Big Toll On Your Body, Study Shows, So Here's How To Relax

  Date : 2018/11/30

  Writer: Other than myself

  Publisher, broadcasting station: elite daily

  Internet
• We May Be More Vulnerable to Stress in the Evening

  Date : 2018/11/29

  Writer: Other than myself

  Publisher, broadcasting station: PsychCentral

  Internet
• 北海道大学、ストレス反応が朝と夜で異なる仕組みを解明～現代社会におけるストレスマネジメントへの応用に期待～

  Date : 2018/11/29

  Publisher, broadcasting station: 日経バイオテクONLINE

  Internet
• Beware of Evening Stress

  Date : 2018/11/28

  Writer: Other than myself

  Publisher, broadcasting station: LabManager

  Internet
• Night Stress Is Different From Morning Stress, A New Study Shows, But Here’s The Best Way To Handle It

  Date : 2018/11/28

  Writer: Other than myself

  Publisher, broadcasting station: Bustle

  Internet
• Your body may not cope with evening stress: Study

  Date : 2018/11/28

  Writer: Other than myself

  Publisher, broadcasting station: NewKerala.com

  Internet
• Evening Stress: Good or Bad?

  Date : 2018/11/27

  Writer: Other than myself

  Publisher, broadcasting station: Medindia

  Internet
• Study suggests possible vulnerability to evening stress

  Date : 2018/11/27

  Publisher, broadcasting station: News-Medical.Net

  Internet
• Beware of evening stress

  Date : 2018/11/26

  Publisher, broadcasting station: AlphaGalileo

  Internet
• Beware of evening stress

  Date : 2018/11/26

  Publisher, broadcasting station: the American Association for the Advancement of Science (AAAS)

  Program, newspaper magazine: EurekAlert!

  Internet
• 医食同源 必須栄養素自ら判断

  Date : 2017/12/14

  Program, newspaper magazine: 北海道新聞

  Paper
• 上手に眠って健康に！快眠の新常識

  Date : 2017/09/19

  Publisher, broadcasting station: STV

  Program, newspaper magazine: どさんんこワイド179

  Media report
• 光と運動で時差ぼけ解消

  Date : 2014/09

  Program, newspaper magazine: 北海道医療新聞

  Paper
• 光の下での運動は生体リズムを調節

  Date : 2014/07/10

  Publisher, broadcasting station: JST科学技術振興機構

  Program, newspaper magazine: Science Portal サイエンスポータル

  Internet
• 北大、「明るい光＋運動」が時差ボケ解消に有効であることを明らかに

  Date : 2014/07/09

  Publisher, broadcasting station: 財経新聞

  Internet
• 光と運動による生体リズム調節のメカニズム

  Date : 2014/07

  Writer: Other than myself

  Program, newspaper magazine: 北海道医療新聞

  Paper