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Nishio Saori
| Hokkaido University Hospital | Professor |
Researcher basic information
■ Degree■ URL
researchmap URLホームページURL■ Various IDs
J-Global ID■ Research Keywords and Fields
Research Keyword
- 常染色体優性多発性嚢胞腎
- Sec63
- 常染色体優性遺伝性肝嚢胞
- 水腎症
- 常染色体優性多発性肝嚢胞
- 細胞増殖
- cilia
- アポトーシス
- トランスジェニックメダカ
- Pkd1ノックアウトマウス
- 多発性嚢胞腎
- PKD2
- PKD1
- ADPKD
- ADPKD、PKD1、PKD2、PKD1ノックアウトマウス
- Bachelor's degree program, Departments of Medicine, School of Medicine
- Master's degree program, Graduate School of Medicine
- Doctoral (PhD) degree program, Graduate School of Medicine
Research activity information
■ Papers- Branched-chain amino acids enhance cyst development in autosomal dominant polycystic kidney disease
Junya Yamamoto; Saori Nishio; Fumihiko Hattanda; Daigo Nakazawa; Toru Kimura; Michio Sata; Minoru Makita; Yasunobu Ishikawa; Tatsuya Atsumi
KIDNEY INTERNATIONAL, 92, 2, 377, 387, Aug. 2017, [Peer-reviewed]
English, Scientific journal - Evidence-based clinical practice guidelines for polycystic kidney disease 2014
Shigeo Horie; Toshio Mochizuki; Satoru Muto; Kazushige Hanaoka; Yoshimitsu Fukushima; Ichiei Narita; Kikuo Nutahara; Ken Tsuchiya; Kazuhiko Tsuruya; Koichi Kamura; Saori Nishio; Tatsuya Suwabe; Yoshifumi Ubara; Eiji Ishimura; Koichi Nakanishi; Keiichi Furukawa; Kenjiro Kimura; Seiichi Matsuo
CLINICAL AND EXPERIMENTAL NEPHROLOGY, 20, 4, 493, 509, Aug. 2016, [Peer-reviewed]
English, Scientific journal - Erratum to: Evidence-based clinical practice guidelines for polycystic kidney disease 2014.
Horie S; Mochizuki T; Muto S; Hanaoka K; Fukushima Y; Narita I; Nutahara K; Tsuchiya K; Tsuruya K; Kamura K; Nishio S; Suwabe T; Ubara Y; Ishimura E; Nakanishi K; Furukawa K; Kimura K; Matsuo S
Clinical and experimental nephrology, 20, 4, 510, Aug. 2016, [Peer-reviewed] - The responses of macrophages in interaction with neutrophils that undergo NETosis
Daigo Nakazawa; Haruki Shida; Yoshihiro Kusunoki; Arina Miyoshi; Saori Nishio; Utano Tomaru; Tatsuya Atsumi; Akihiro Ishizu
JOURNAL OF AUTOIMMUNITY, 67, 19, 28, Feb. 2016, [Peer-reviewed]
English, Scientific journal - Peptidylarginine Deiminase Inhibitor Suppresses Neutrophil Extracellular Trap Formation and MPO-ANCA Production.
Kusunoki Y; Nakazawa D; Shida H; Hattanda F; Miyoshi A; Masuda S; Nishio S; Tomaru U; Atsumi T; Ishizu A
Frontiers in immunology, 7, 227, 2016, [Peer-reviewed] - Transcatheter Arterial Embolization with Ethanol Injection in Symptomatic Patients with Enlarged Polycystic Kidneys.
Yusuke Sakuhara; Saori Nishio; Ken Morita; Daisuke Abo; Yu Hasegawa; Noriaki Yuasa; Toshio Mochizuki; Takeshi Soyama; Koji Oba; Hiroki Shirato; Kohsuke Kudo
Radiology, 277, 1, 277, 85, Oct. 2015, [Peer-reviewed], [International Magazine]
English, Scientific journal, PURPOSE: To evaluate the safety and effectiveness of transcatheter arterial embolization (TAE) with ethanol in symptomatic patients with enlarged polycystic kidney disease. MATERIALS AND METHODS: This prospective study was institutional review board approved and was planned for patients with symptoms related to enlarged polycystic kidney disease, such as a markedly distended abdomen, gastroesophageal reflux, and abdominal pain. At the time of TAE, all patients were undergoing dialysis therapy for chronic renal failure, and their urinary volume had decreased to less than 500 mL per day. Bilateral renal TAE with absolute ethanol was performed, and changes in kidney volume, clinical symptoms, laboratory data, and complications were evaluated after TAE. The differences in patients' kidney volumes, clinical symptoms, abdominal circumference, and dry weights before and after TAE were analyzed with a mixed effect model. RESULTS: Fifteen patients (seven men and eight women; mean age, 57.7 years ± 5.3 [standard deviation]) were treated. Among the 15 patients, the follow-up period was 24 months in 13 patients, 6 months in one patient, and 3 months in one patient. The mean kidney volume was 3380 mL before renal TAE, and at 3, 12, and 24 months after TAE, it significantly decreased to 60.9%, 39.8%, and 32.1% of the pretherapeutic value, respectively (P < .001). All patients reported improved clinical symptoms within 3 months after TAE (P < .001). Abdominal circumferences were significantly decreased after TAE (P < .001). The dry weights also continued to significantly decreased until 6 months after TAE (P < .001), at which point they began to slightly increase until 24 months after TAE. Abdominal pain, nausea, and inflammatory response developed in all patients after TAE, but these symptoms improved with conservative treatment. Abscess formation was found in one kidney, and drainage catheter placement was performed. No major complications related to TAE occurred in the remaining patients. CONCLUSION: Renal contraction therapy by TAE with ethanol injection appears to be a safe and effective treatment in patients with symptomatic enlarged polycystic kidney disease. - Outcomes of primary nephrotic syndrome in elderly Japanese: retrospective analysis of the Japan Renal Biopsy Registry (J-RBR)
Hitoshi Yokoyama; Hitoshi Sugiyama; Ichiei Narita; Takao Saito; Kunihiro Yamagata; Saori Nishio; Shouichi Fujimoto; Noriko Mori; Yukio Yuzawa; Seiya Okuda; Shoichi Maruyama; Hiroshi Sato; Yoshihiko Ueda; Hirofumi Makino; Seiichi Matsuo
CLINICAL AND EXPERIMENTAL NEPHROLOGY, 19, 3, 496, 505, Jun. 2015, [Peer-reviewed]
English, Scientific journal - The first pure form of Ostertag-type amyloidosis in Japan: a sporadic case of hereditary fibrinogen A alpha-chain amyloidosis associated with a novel frameshift variant
Masahide Yazaki; Tsuneaki Yoshinaga; Yoshiki Sekijima; Saori Nishio; Yuji Kanizawa; Fuyuki Kametani; Kana Miyashita; Naomi Hachiya; Keiichi Higuchi; Shu-ichi Ikeda
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS, 22, 2, 142, 144, Jun. 2015, [Peer-reviewed]
English - [Polycystic kidney disease].
Nishio S
Nihon Jinzo Gakkai shi, 57, 8, 1354, 1358, 2015, [Peer-reviewed] - Diffuse renal (18)F-FDG uptake of a patient with fever of unknown origin revealed sarcoidosis.
Takuya Toyonaga; Osamu Manabe; Florian C Gaertner; Tasuku Nakagaki; Saori Nishio; Akira Suzuki; Nagara Tamaki
Clinical nuclear medicine, 39, 7, 648, 9, Jul. 2014, [Peer-reviewed], [International Magazine]
English, We report about the usefulness of F-FDG PET for the detection and therapy response evaluation of renal sarcoidosis. A 55-year-old woman presented with a condition diagnosed with pulmonary and ocular sarcoidosis 2 years before having anemia and acute deterioration of renal function. FDG PET revealed diffuse increased FDG uptake in both kidneys and the spleen. Histopathologic examination of a renal biopsy sample revealed granulomatous interstitial nephritis with sarcoidosis. After methylprednisolone treatment, the abnormal FDG uptake resolved completely with improvement of symptoms. FDG PET is a useful tool to detect active sarcoidosis regions and to monitor treatment efficacy. - Enhanced Formation and Disordered Regulation of NETs in Myeloperoxidase-ANCA-Associated Microscopic Polyangiitis
Daigo Nakazawa; Haruki Shida; Utano Tomaru; Masaharu Yoshida; Saori Nishio; Tatsuya Atsumi; Akihiro Ishizu
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 25, 5, 990, 997, May 2014, [Peer-reviewed]
English, Scientific journal - [NETs in pathogenesis of vasculitis].
Nakazawa D; Nishio S; Tomaru U; Atsumi T; Ishizu A
Nihon Jinzo Gakkai shi, 56, 2, 117, 123, 2014, [Peer-reviewed] - [Case report; A case of familial focal segmental glomerulosclerosis with a mutation in the formin INF2].
Yamamoto J; Nakazawa D; Tsukaguchi H; Toyoyama T; Sato A; Nakagaki T; Ishikawa Y; Shibazaki S; Nishio S; Atsumi T
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 102, 5, 1220, 1222, May 2013, [Peer-reviewed] - Successful Delivery in a Patient with Antineutrophil Cytoplasmic Antibody-associated Glomerulonephritis
Megumi Oshima; Shinji Kitajima; Tadashi Toyama; Akinori Hara; Kiyoki Kitagawa; Yasunori Iwata; Miho Shimizu; Saori Nishio; Junko Imura; Hitoshi Yokoyama; Kengo Furuichi; Shuichi Kaneko; Takashi Wada
INTERNAL MEDICINE, 52, 14, 1605, 1609, 2013, [Peer-reviewed]
English, Scientific journal - Abnormal conformation and impaired degradation of propylthiouracil-induced neutrophil extracellular traps Implications of disordered neutrophil extracellular traps in a rat model of myeloperoxidase antineutrophil cytoplasmic antibody-associated vasculitis
Daigo Nakazawa; Utano Tomaru; Akira Suzuki; Sakiko Masuda; Risa Hasegawa; Toshiaki Kobayashi; Saori Nishio; Masanori Kasahara; Akihiro Ishizu
ARTHRITIS AND RHEUMATISM, 64, 11, 3779, 3787, Nov. 2012, [Peer-reviewed]
English, Scientific journal - Renal disease progression in autosomal dominant polycystic kidney disease
Eiji Higashihara; Shigeo Horie; Satoru Muto; Toshio Mochizuki; Saori Nishio; Kikuo Nutahara
CLINICAL AND EXPERIMENTAL NEPHROLOGY, 16, 4, 622, 628, Aug. 2012, [Peer-reviewed]
English, Scientific journal - A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation
Sorin V. Fedeles; Xin Tian; Anna-Rachel Gallagher; Michihiro Mitobe; Saori Nishio; Seung Hun Lee; Yiqiang Cai; Lin Geng; Craig M. Crews; Stefan Somlo
NATURE GENETICS, 43, 7, 639, U163, Jul. 2011, [Peer-reviewed]
English, Scientific journal - Transplantation-associated thrombotic microangiopathy after steroid pulse therapy for polyserositis related to graft-versus-host disease
Yasunobu Ishikawa; Saori Nishio; Hiroaki Sasaki; Risshi Kudo; Hideki Goto; Masanori Ito; Akira Suzuki; Yuichiro Fukazawa; Toshio Mochizuki; Takao Koike
CLINICAL AND EXPERIMENTAL NEPHROLOGY, 15, 1, 179, 183, Feb. 2011, [Peer-reviewed]
English, Scientific journal - Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis
Vinita Takiar; Saori Nishio; Patricia Seo-Mayer; J. Darwin King; Hui Li; Li Zhang; Anil Karihaloo; Kenneth R. Hallows; Stefan Somlo; Michael J. Caplan
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108, 6, 2462, 2467, Feb. 2011, [Peer-reviewed]
English, Scientific journal - Distinct Macrophage Phenotypes Contribute to Kidney Injury and Repair
Sik Lee; Sarah Huen; Hitoshi Nishio; Saori Nishio; Heung Kyu Lee; Bum-Soon Choi; Christiana Ruhrberg; Lloyd G. Cantley
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 22, 2, 317, 326, Feb. 2011, [Peer-reviewed]
English, Scientific journal - Loss of Oriented Cell Division Does not Initiate Cyst Formation
Saori Nishio; Xin Tian; Anna Rachel Gallagher; Zhiheng Yu; Vishal Patel; Peter Igarashi; Stefan Somlo
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 21, 2, 295, 302, Feb. 2010, [Peer-reviewed]
English, Scientific journal - A kelch family protein Nd1-L functions as a metastasis suppressor in cancer cells via Rho family proteins mediated mechanism
Yoshihito Ohta; Lisa Fujimura; Saori Nishio; Masafumi Arima; Akemi Sakamoto; Hideaki Shimada; Takenori Ochiai; Takeshi Tokuhisa; Masahiko Hatano
INTERNATIONAL JOURNAL OF ONCOLOGY, 36, 2, 427, 434, Feb. 2010, [Peer-reviewed]
English, Scientific journal - [Pauchi-immune crescentic glomerulonephritis associated with rheumatoid arthritis].
Kudo R; Hashimoto S; Sasaki H; Nakagaki T; Maoka T; Ishikawa Y; Nishio S; Mochizuki T; Koike T
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 98, 11, 2879, 2881, 11, Nov. 2009, [Peer-reviewed]
Japanese, 症例は76歳の男性.1995年より関節リウマチ及び関節リウマチに伴う器質化肺炎(BOOP)にて加療中であった.2008年1月に初めて顕微鏡的血尿を指摘され,その後急速な腎機能障害の進行を認め同年6月当科紹介初診となった.潜血の他,蛋白尿も認め急速進行性糸球体腎炎(RPGN)を疑い入院予定とした.しかしBOOPが急速に増悪し,近医にてステロイドの内服加療が開始された.その後徐々に腎機能は改善傾向を示し,入院時には腎機能は改善傾向を示し,尿蛋白の陰性化も認めた.経皮的腎生検を施行し,結果は半月体形成性糸球体腎炎(pauchi-immune type)であった.なおANCAは陰性であった.関節リウマチに関連する腎障害としては薬剤性やアミロイドーシスが有名であるが,腎炎そのものは稀とされる.さらに半月体形成性糸球体腎炎を示す少数の過去の報告例でもp-ANCA関連腎炎が大半を占める.また,BOOPと半月体形成性糸球体腎炎との合併例の報告は未だに無い.本例ではステロイドの加療によりBOOPと腎炎が同時に改善しているなど関節リウマチに伴う合併症を考察する上で稀少で示唆に富む症例と考えここに報告する. - A murine model of neonatal diabetes mellitus in Glis3-deficient mice
Naoki Watanabe; Kentaro Hiramatsu; Rieko Miyamoto; Kaoru Yasuda; Norihiko Suzuki; Naoko Oshima; Hiroshi Kiyonari; Dai Shiba; Saori Nishio; Toshio Mochizuki; Takahiko Yokoyama; Shoichi Maruyama; Seiichi Matsuo; Yuko Wakamatsu; Hisashi Hashimoto
FEBS LETTERS, 583, 12, 2108, 2113, Jun. 2009, [Peer-reviewed]
English, Scientific journal - Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1
Sekiya Shibazaki; Zhiheng Yu; Saori Nishio; Xin Tian; R. Brent Thomson; Michihiro Mitobe; Angeliki Louvi; Heino Velazquez; Shuta Ishibe; Lloyd G. Cantley; Peter Igarashi; Stefan Somlo
HUMAN MOLECULAR GENETICS, 17, 11, 1505, 1516, Jun. 2008, [Peer-reviewed]
English, Scientific journal - Overexpression of Nd1, a novel Kelch family protein, in the heart of transgenic mice protects against doxorubicin-induced cardiomyopathy
Yuji Matsudo; Yasuyuki Takamori; Lisa Fujimura; Saori Nishio; Kazushi Sasagawa; Issei Komuro; Takeshi Tokuhisa; Masahiko Hatano
TRANSGENIC RESEARCH, 15, 5, 573, 581, Oct. 2006, [Peer-reviewed]
English, Scientific journal - Pkd1 regulates immortalized proliferation of renal tubular epithelial cells through p53 induction and JNK activation
S Nishio; M Hatano; M Nagata; S Horie; T Koike; T Tokuhisa; T Mochizuki
JOURNAL OF CLINICAL INVESTIGATION, 115, 4, 910, 918, Apr. 2005, [Peer-reviewed]
English, Scientific journal - Skeletal affinity of Tc(V)-DMS is bone cell mediated and pH dependent
K Horiuchi-Suzuki; A Konno; M Ueda; Y Fukuda; S Nishio; K Hashimoto; H Saji
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 31, 3, 388, 398, Mar. 2004, [Peer-reviewed]
English, Scientific journal
- Planar cell polarity in polycystic kidney disease
NISHIO Saori, The Japanese journal of nephrology, 54, 4, 497, 500, 25 May 2012
日本腎臓学会, Japanese - Clinical guidelines for the management of polycystic kidney disease
乳原 善文; 香村 衝一; 木村 理; 嶋村 剛; 田邉 一成; 土谷 健; 成田 一衛; 中西 浩一; 西尾 妙織; 奴田原 紀久雄; 村 信介; 花岡 一成; 東原 英二; 堀江 重郎; 武藤 智; 望月 俊雄, The Japanese journal of nephrology, 53, 4, 556, 583, 25 May 2011
日本腎臓学会, Japanese - A patient with huge ectopic calcification that was diminished after conversion to prolonged hemodialysis
ISHIKAWA Yasunobu; NISHIO Saori; CHIBA Takashi; SATO Akiko; KIMACHI Miho; IKENOUE Tatsuyoshi; NAKAGAKI Tasuku; NAKAZAWA Daigo; ITO Masanori; SHIBAZAKI Sekiya; MORITA Ken; NONOMURA Katsuya; KOIKE Takao, Nihon Toseki Igakkai Zasshi, 44, 2, 173, 179, 28 Feb. 2011
A 35-year-old man had undergone maintenance hemodialysis therapy since 1998, which however was switched to peritoneal dialysis because of blood access problems in 2000. He developed huge ectopic calcifications in the right shoulder and left buttock in December 2003 due to hyperphosphatemia and calcium-phosphate product above 90 (mg/dL)<SUP>2</SUP>. To improve hyperphosphatemia and ectopic calcifications, the dialysis modality was converted to hemodialysis in October 2004. However, the ectopic calcifications progressively worsened. He was referred to our hospital for kidney transplantation i..., The Japanese Society for Dialysis Therapy, Japanese - Pauchi-immune crescentic glomerulonephritis associated with rheumatoid arthritis
KUDO Risshi; HASHIMOTO Seiji; SASAKI Hiroaki; NAKAGAKI Tasuku; MAOKA Tomochika; ISHIKAWA Yasunobu; NISHIO Saori; MOCHIZUKI Toshio; KOIKE Takao, Nihon Naika Gakkai Zasshi, 98, 11, 2879, 2881, 10 Nov. 2009
症例は76歳の男性.1995年より関節リウマチ及び関節リウマチに伴う器質化肺炎(BOOP)にて加療中であった.2008年1月に初めて顕微鏡的血尿を指摘され,その後急速な腎機能障害の進行を認め同年6月当科紹介初診となった.潜血の他,蛋白尿も認め急速進行性糸球体腎炎(RPGN)を疑い入院予定とした.しかしBOOPが急速に増悪し,近医にてステロイドの内服加療が開始された.その後徐々に腎機能は改善傾向を示し,入院時には腎機能は改善傾向を示し,尿蛋白の陰性化も認めた.経皮的腎生検を施行し,結果は半月体形成性糸球体腎炎(pauchi-immune type)であった.なおANCAは陰性であった.関節リウマチに関連する腎障害としては薬剤性やアミロイドーシスが有名であるが,腎炎そのものは稀とされる.さらに半月体形成性糸球体腎炎を示す少数の過去の報告例でもp-ANCA関連腎炎が大半を占める.また,BOOPと半月体形成性糸球体腎炎との合併例の報告は未だに無い.本例ではステロイドの加療によりBOOPと腎炎が同時に改善しているなど関節リウマチに伴う合併症を考察する上で稀少で示唆に富む症例と考えここに報告する., The Japanese Society of Internal Medicine, Japanese - pkd1ノックアウトキメラマウスを用いた嚢胞形成機序の検討
西尾 妙織, 北海道醫學雜誌 = Acta medica Hokkaidonensia, 79, 6, 695, 703, 01 Nov. 2004
Japanese - Propylthiouracil induced ANCA-associated nephritis occured in the course of membranous nephropathy.
Nishio Saori; Shibazaki Sekiya; yamamura Tuyoshi; Sasaki Naomi; yamada Kanji; Kawata Tetuya; Koike Takao; Hidetosi Satou, Nihon Naika Gakkai Zasshi, 90, 2, 332, 334, 10 Feb. 2001
症例は40歳,女性. Basedow氏病にてpropylthiouracil (PTU)を内服.血尿,蛋白あり腎生検で膜性腎症と診断される. 2年後に急速な腎機能低下を呈し再度腎生検を施行.膜性腎症の所見に加えて,間質への広範な細胞浸潤を認めた. MPO-ANCA高値であり,膜性腎症にPTUによるANCA関連腎炎を合併したものと診断した., The Japanese Society of Internal Medicine, Japanese
