Daigo Hashimotoresearchmap個人ページ

Last Updated : 2018/09/14

Basic Information

Profile

Affiliation
Faculty of Medicine Internal Medicine
Job TitleAssociate Professor 
Degree
M.D.(Ph.D.)
E-mail
URL
Research funding number

Research Keywords

Hematopoietic stem cell transplantation, Graft versus host disease, Macrophage, Innate Immunity

Research Areas

Basic medicine / Immunology
Clinical internal medicine / Hematology
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Basic medicine / Immunology
Clinical internal medicine / Hematology

Career

2018/04
-
Today
Hokkaido University, Faculty of Medicine(Associate Professor)
2013
-
2015
Hokkaido University(Tenure-Track Assistant Professor)
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Employmentclose
2018/04
-
Today
Hokkaido University, Faculty of Medicine(Associate Professor)
2013
-
2015
Hokkaido University(Tenure-Track Assistant Professor)

Academic Background

2001
-
2005
Okayama University Graduate School of Medicine and Dentistry Sciences
1991
-
1997
Okayama University Medical School
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2001
-
2005
Okayama University Graduate School of Medicine and Dentistry Sciences
1991
-
1997
Okayama University Medical School

Academic Societies

The American Society of Hematology
THE JAPAN SOCIETY OF TRANSFUSION MEDICINE AND CELL THERAPY
Japan Society for Hematopoietic Stem Cell Transplantation
The JAPANESE SOCIETY OF HEMATOLOGY
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The American Society of Hematology
THE JAPAN SOCIETY OF TRANSFUSION MEDICINE AND CELL THERAPY
Japan Society for Hematopoietic Stem Cell Transplantation
The JAPANESE SOCIETY OF HEMATOLOGY

Research Activities

Papers

Disseminated fusariosis emerged from prolonged local genital infection after cord blood transplantation.
Okada K, Endo T, Hashimoto D, Saga T, Ara T, Ogasawara R, Yasumoto A, Ibata M, Takahata M, Shigematsu A, Kondo T, Muraosa Y, Nomura T, Kanno-Okada H, Hashino S, Tanaka S, Kamei K, Teshima T
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 24(8) 660-663 2018/08
Development of a Fluorescence in Situ Hybridization Probe for Detecting IKZF1 Deletion Mutations in Patients with Acute Lymphoblastic Leukemia.
Hashiguchi J, Onozawa M, Oguri S, Fujisawa S, Tsuji M, Okada K, Nakagawa M, Hashimoto D, Kahata K, Kondo T, Shimizu C, Teshima T
The Journal of molecular diagnostics : JMD 20(4) 446-454 2018/07
Intestinal Lymphatic Endothelial Cells Produce R-Spondin3.
Ogasawara R, Hashimoto D, Kimura S, Hayase E, Ara T, Takahashi S, Ohigashi H, Yoshioka K, Tateno T, Yokoyama E, Ebata K, Kondo T, Sugita J, Onozawa M, Iwanaga T, Teshima T
Scientific reports 8(1) 10719 2018/07
The association between the incidence of intestinal graft-vs-host disease and antibiotic use after allogeneic hematopoietic stem cell transplantation.
Hidaka D, Hayase E, Shiratori S, Hasegawa Y, Ishio T, Tateno T, Okada K, Goto H, Sugita J, Onozawa M, Nakagawa M, Kahata K, Endo T, Hashimoto D, Teshima T
Clinical transplantation e13361 2018/07
Wilms Tumor 1 Expression at Diagnosis Correlates With Genetic Abnormalities and Polymorphism But Is Not Independently Prognostic in Acute Myelogenous Leukemia: A Hokkaido Leukemia Net Study.
Hidaka D, Onozawa M, Hashiguchi J, Miyashita N, Kasahara K, Fujisawa S, Hayase E, Okada K, Shiratori S, Goto H, Sugita J, Nakagawa M, Hashimoto D, Kahata K, Endo T, Yamamoto S, Tsutsumi Y, Haseyama Y, Nagashima T, Mori A, Ota S, Sakai H, Ishihara T, Imai K, Miyagishima T, Kakinoki Y, Kurosawa M, Kobayashi H, Iwasaki H, Shimizu C, Kondo T, Teshima T
Clinical lymphoma, myeloma & leukemia 2018/07
Hematogones Predict Better Outcome in Allogeneic Hematopoietic Stem Cell Transplantation Irrespective of Graft Sources.
Ishio T, Sugita J, Tateno T, Hidaka D, Hayase E, Shiratori S, Okada K, Goto H, Onozawa M, Nakagawa M, Hashimoto D, Kahata K, Fujimoto K, Endo T, Kondo T, Teshima T
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2018/06
Cecum ulcer is a reliable endoscopic finding in cytomegalovirus colitis concomitant with graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.
Matsuda K, Ono S, Ishikawa M, Miyamoto S, Abiko S, Tsuda M, Yamamoto K, Kudo T, Shimizu Y, Hayase E, Hashimoto D, Teshima T, Matsuno Y, Sakamoto N
Annals of hematology 97(5) 877-883 2018/05
Ruxolitinib protects skin stem cells and maintains skin homeostasis in murine graft-versus-host disease.
Takahashi S, Hashimoto D, Hayase E, Ogasawara R, Ohigashi H, Ara T, Yokoyama E, Ebata K, Matsuoka S, Hill GR, Sugita J, Onozawa M, Teshima T
Blood 131(18) 2074-2085 2018/05
A novel heterozygous ITGB3 p.T720del inducing spontaneous activation of integrin αIIbβ3 in autosomal dominant macrothrombocytopenia with aggregation dysfunction.
Miyashita N, Onozawa M, Hayasaka K, Yamada T, Migita O, Hata K, Okada K, Goto H, Nakagawa M, Hashimoto D, Kahata K, Kondo T, Kunishima S, Teshima T
Annals of hematology 97(4) 629-640 2018/04
Vitamin A-coupled liposomes containing siRNA against HSP47 ameliorate skin fibrosis in chronic graft-versus-host disease.
Yamakawa T, Ohigashi H, Hashimoto D, Hayase E, Takahashi S, Miyazaki M, Minomi K, Onozawa M, Niitsu Y, Teshima T
Blood 131(13) 1476-1485 2018/03
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Papersclose
Disseminated fusariosis emerged from prolonged local genital infection after cord blood transplantation.
Okada K, Endo T, Hashimoto D, Saga T, Ara T, Ogasawara R, Yasumoto A, Ibata M, Takahata M, Shigematsu A, Kondo T, Muraosa Y, Nomura T, Kanno-Okada H, Hashino S, Tanaka S, Kamei K, Teshima T
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 24(8) 660-663 2018/08
Development of a Fluorescence in Situ Hybridization Probe for Detecting IKZF1 Deletion Mutations in Patients with Acute Lymphoblastic Leukemia.
Hashiguchi J, Onozawa M, Oguri S, Fujisawa S, Tsuji M, Okada K, Nakagawa M, Hashimoto D, Kahata K, Kondo T, Shimizu C, Teshima T
The Journal of molecular diagnostics : JMD 20(4) 446-454 2018/07
Intestinal Lymphatic Endothelial Cells Produce R-Spondin3.
Ogasawara R, Hashimoto D, Kimura S, Hayase E, Ara T, Takahashi S, Ohigashi H, Yoshioka K, Tateno T, Yokoyama E, Ebata K, Kondo T, Sugita J, Onozawa M, Iwanaga T, Teshima T
Scientific reports 8(1) 10719 2018/07
The association between the incidence of intestinal graft-vs-host disease and antibiotic use after allogeneic hematopoietic stem cell transplantation.
Hidaka D, Hayase E, Shiratori S, Hasegawa Y, Ishio T, Tateno T, Okada K, Goto H, Sugita J, Onozawa M, Nakagawa M, Kahata K, Endo T, Hashimoto D, Teshima T
Clinical transplantation e13361 2018/07
Wilms Tumor 1 Expression at Diagnosis Correlates With Genetic Abnormalities and Polymorphism But Is Not Independently Prognostic in Acute Myelogenous Leukemia: A Hokkaido Leukemia Net Study.
Hidaka D, Onozawa M, Hashiguchi J, Miyashita N, Kasahara K, Fujisawa S, Hayase E, Okada K, Shiratori S, Goto H, Sugita J, Nakagawa M, Hashimoto D, Kahata K, Endo T, Yamamoto S, Tsutsumi Y, Haseyama Y, Nagashima T, Mori A, Ota S, Sakai H, Ishihara T, Imai K, Miyagishima T, Kakinoki Y, Kurosawa M, Kobayashi H, Iwasaki H, Shimizu C, Kondo T, Teshima T
Clinical lymphoma, myeloma & leukemia 2018/07
Hematogones Predict Better Outcome in Allogeneic Hematopoietic Stem Cell Transplantation Irrespective of Graft Sources.
Ishio T, Sugita J, Tateno T, Hidaka D, Hayase E, Shiratori S, Okada K, Goto H, Onozawa M, Nakagawa M, Hashimoto D, Kahata K, Fujimoto K, Endo T, Kondo T, Teshima T
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2018/06
Cecum ulcer is a reliable endoscopic finding in cytomegalovirus colitis concomitant with graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.
Matsuda K, Ono S, Ishikawa M, Miyamoto S, Abiko S, Tsuda M, Yamamoto K, Kudo T, Shimizu Y, Hayase E, Hashimoto D, Teshima T, Matsuno Y, Sakamoto N
Annals of hematology 97(5) 877-883 2018/05
Ruxolitinib protects skin stem cells and maintains skin homeostasis in murine graft-versus-host disease.
Takahashi S, Hashimoto D, Hayase E, Ogasawara R, Ohigashi H, Ara T, Yokoyama E, Ebata K, Matsuoka S, Hill GR, Sugita J, Onozawa M, Teshima T
Blood 131(18) 2074-2085 2018/05
A novel heterozygous ITGB3 p.T720del inducing spontaneous activation of integrin αIIbβ3 in autosomal dominant macrothrombocytopenia with aggregation dysfunction.
Miyashita N, Onozawa M, Hayasaka K, Yamada T, Migita O, Hata K, Okada K, Goto H, Nakagawa M, Hashimoto D, Kahata K, Kondo T, Kunishima S, Teshima T
Annals of hematology 97(4) 629-640 2018/04
Vitamin A-coupled liposomes containing siRNA against HSP47 ameliorate skin fibrosis in chronic graft-versus-host disease.
Yamakawa T, Ohigashi H, Hashimoto D, Hayase E, Takahashi S, Miyazaki M, Minomi K, Onozawa M, Niitsu Y, Teshima T
Blood 131(13) 1476-1485 2018/03
T-cell depletion effects of low-dose antithymocyte globulin for GVHD prophylaxis in HLA-matched allogeneic peripheral blood stem cell transplantation.
Shiratori S, Kosugi-Kanaya M, Hayase E, Okada K, Goto H, Sugita J, Onozawa M, Nakagawa M, Kahata K, Hashimoto D, Endo T, Kondo T, Teshima T
Transplant immunology 46 21-22 2018/02
R-Spondin1 expands Paneth cells and prevents dysbiosis induced by graft-versus-host disease.
Hayase E, Hashimoto D, Nakamura K, Noizat C, Ogasawara R, Takahashi S, Ohigashi H, Yokoi Y, Sugimoto R, Matsuoka S, Ara T, Yokoyama E, Yamakawa T, Ebata K, Kondo T, Hiramine R, Aizawa T, Ogura Y, Hayashi T, Mori H, Kurokawa K, Tomizuka K, Ayabe T, Teshima T
The Journal of experimental medicine 214(12) 3507-3518 2017/12
Diffuse large B-cell lymphoma with a bulky mass in the cranial vault
Minoru Kanaya, Minoru Kanaya, Tomoyuki Endo, Daigo Hashimoto, Shogo Endo, Shogo Endo, Ryo Takemura, Ryo Takemura, Kohei Okada, Kanako C. Hatanaka, Yoshihiro Matsuno, Takanori Teshima
International Journal of Hematology 106 147-148 2017/08
Disseminated toxoplasmosis after hematopoietic stem cell transplantation showing unusual magnetic resonance images.
Tateno T, Onozawa M, Hashiguchi J, Ishio T, Yuzawa S, Matsuoka S, Kosugi-Kanaya M, Okada K, Shiratori S, Goto H, Kimura T, Sugita J, Nakagawa M, Hashimoto D, Kahata K, Fujimoto K, Endo T, Kondo T, Tanaka S, Hashino S, Teshima T
Transplant infectious disease : an official journal of the Transplantation Society 19(4) 2017/08
Risk factors of human herpesvirus 6 encephalitis/myelitis after allogeneic hematopoietic stem cell transplantation
Naohiro Miyashita, Tomoyuki Endo, Masahiro Onozawa, Daigo Hashimoto, Takeshi Kondo, Katsuya Fujimoto, Kaoru Kahata, Junichi Sugita, Hideki Goto, Toshihiro Matsukawa, Satoshi Hashino, Takanori Teshima
Transplant Infectious Disease 19 2017/06
MALDI-TOF MS in post-transplant bloodstream infections: Reliable identification of causative bacteria in the neutropenic phase
M. Kanaya, Y. Hayashi, D. Hashimoto, T. Endo, J. Sugita, H. Ohigashi, J. Hashiguchi, T. Matsukawa, S. Matsuoka, M. Kosugi-Kanaya, M. Kosugi-Kanaya, H. Goto, M. Onozawa, K. Kahata, K. Kahata, K. Fujimoto, T. Kondo, K. Akizawa, H. Shibuya, C. Shimizu, T. Teshima
Bone Marrow Transplantation 52 778-780 2017/05
Graft-versus-host disease targets ovary and causes female infertility in mice
Sonoko Shimoji, Sonoko Shimoji, Daigo Hashimoto, Hidetsugu Tsujigiwa, Kohta Miyawaki, Koji Kato, Shuichiro Takahashi, Reiki Ogasawara, Takashi Jiromaru, Hiromi Iwasaki, Toshihiro Miyamoto, Koichi Akashi, Koichi Akashi, Takanori Teshima
Blood 129 1216-1225 2017/03
Leukemogenic kinase FIP1L1-PDGFRA and a small ubiquitin-like modifier E3 ligase, PIAS1, form a positive cross-talk through their enzymatic activities
Makoto Ibata, Junko Iwasaki, Yoichiro Fujioka, Koji Nakagawa, Stephanie Darmanin, Masahiro Onozawa, Daigo Hashimoto, Yusuke Ohba, Shigetsugu Hatakeyama, Takanori Teshima, Takeshi Kondo
Cancer Science 108 200-207 2017/02
Graft-versus-host disease in the ovary potentially causes female infertility after allogeneic hematopoietic stem cell transplantation.
Shimoji S, Hashimoto D, Teshima T
[Rinsho ketsueki] The Japanese journal of clinical hematology 58(7) 827-834 2017
Reduced-dose methotrexate in combination with tacrolimus was associated with rapid engraftment and recovery from oral mucositis without affecting the incidence of GVHD
Toshihiro Matsukawa, Daigo Hashimoto, Junichi Sugita, Seitarou Nakazawa, Takae Matsushita, Haruhiko Kashiwazaki, Hideki Goto, Masahiro Onozawa, Kaoru Kahata, Katsuya Fujimoto, Tomoyuki Endo, Takeshi Kondo, Satoshi Hashino, Yutaka Yamazaki, Takanori Teshima
International Journal of Hematology 104 117-124 2016/07
Expansion and Activation of CD103+ Dendritic Cell Progenitors at the Tumor Site Enhances Tumor Responses to Therapeutic PD-L1 and BRAF Inhibition
Hélène Salmon, Hélène Salmon, Hélène Salmon, Juliana Idoyaga, Adeeb Rahman, Marylène Leboeuf, Marylène Leboeuf, Marylène Leboeuf, Romain Remark, Romain Remark, Stefan Jordan, Stefan Jordan, Stefan Jordan, Maria Casanova-Acebes, Maria Casanova-Acebes, Maria Casanova-Acebes, Makhzuna Khudoynazarova, Makhzuna Khudoynazarova, Makhzuna Khudoynazarova, Judith Agudo, Judith Agudo, Judith Agudo, Navpreet Tung, Navpreet Tung, Navpreet Tung, Svetoslav Chakarov, Christina Rivera, Christina Rivera, Christina Rivera, Brandon Hogstad, Brandon Hogstad, Brandon Hogstad, Marcus Bosenberg, Daigo Hashimoto, Sacha Gnjatic, Sacha Gnjatic, Nina Bhardwaj, Nina Bhardwaj, Anna Karolina Palucka, Brian D. Brown, Brian D. Brown, Brian D. Brown, Joshua Brody, Joshua Brody, Florent Ginhoux, Miriam Merad, Miriam Merad, Miriam Merad
Immunity 44 924-938 2016/04
The Mononuclear Phagocyte System in Organ Transplantation
J. Ochando, W. H. Kwan, F. Ginhoux, J. A. Hutchinson, D. Hashimoto, M. Collin
American Journal of Transplantation 16 1053-1069 2016/04
Allogeneic hematopoietic stem cell transplantation following reduced-intensity conditioning for mycosis fungoides and Sezary syndrome
Souichi Shiratori, Katsuya Fujimoto, Machiko Nishimura, Kanako C. Hatanaka, Mizuha Kosugi-Kanaya, Kohei Okada, Junichi Sugita, Akio Shigematsu, Daigo Hashimoto, Tomoyuki Endo, Takeshi Kondo, Riichiro Abe, Satoshi Hashino, Yoshihiro Matsuno, Hiroshi Shimizu, Takanori Teshima
Hematological Oncology 34 9-16 2016/03
Key players in intestinal GVHD
Daigo Hashimoto, Takanori Teshima
[Rinshō ketsueki] The Japanese journal of clinical hematology 56 807-814 2015/07
Requirement for innate immunity and CD90 NK1.1 lymphocytes to treat established melanoma with chemo-immunotherapy
Marina Moskalenko, Michael Pan, Yichun Fu, Ellen H. De Moll, Daigo Hashimoto, Daigo Hashimoto, Arthur Mortha, Marylene Leboeuf, Padmini Jayaraman, Sebastian Bernardo, Andrew G. Sikora, Jedd Wolchok, Nina Bhardwaj, Nina Bhardwaj, Miriam Merad, Miriam Merad, Yvonne Saenger, Yvonne Saenger, Yvonne Saenger
Cancer Immunology Research 3 296-304 2015/03
Decreased secretion of Paneth cell α-defensins in graft-versus-host disease
Y. Eriguchi, K. Nakamura, D. Hashimoto, S. Shimoda, N. Shimono, K. Akashi, T. Ayabe, T. Teshima
Transplant Infectious Disease 17 702-706 2015/01
α-Mannan induces Th17-mediated pulmonary graft-versus-host disease in mice
Hidetaka Uryu, Hidetaka Uryu, Daigo Hashimoto, Koji Kato, Eiko Hayase, Satomi Matsuoka, Reiki Ogasawara, Shuichiro Takahashi, Yoshinobu Maeda, Hiromi Iwasaki, Toshihiro Miyamoto, Shinobu Saijo, Yoichiro Iwakura, Geoffrey R. Hill, Koichi Akashi, Koichi Akashi, Takanori Teshima
Blood 125 3014-3023 2015/01
Erratum: Crosstalk between muscularis macrophages and enteric neurons regulates gastrointestinal motility (Cell (2014) 158 (300â€"313) )
Paul Andrew Muller, Balázs Koscsó, Gaurav Manohar Rajani, Korey Stevanovic, Marie Luise Berres, Daigo Hashimoto, Arthur Mortha, Marylene Leboeuf, Xiu Min Li, Daniel Mucida, E. Richard Stanley, Stephanie Dahan, Kara Gross Margolis, Michael David Gershon, Miriam Merad, Milena Bogunovic
Cell 158 1210 2014/08
Crosstalk between muscularis macrophages and enteric neurons regulates gastrointestinal motility
Paul Andrew Muller, Paul Andrew Muller, Paul Andrew Muller, Paul Andrew Muller, Balázs Koscsó, Gaurav Manohar Rajani, Korey Stevanovic, Marie Luise Berres, Marie Luise Berres, Marie Luise Berres, Daigo Hashimoto, Daigo Hashimoto, Daigo Hashimoto, Daigo Hashimoto, Arthur Mortha, Arthur Mortha, Arthur Mortha, Marylene Leboeuf, Marylene Leboeuf, Marylene Leboeuf, Xiu Min Li, Xiu Min Li, Daniel Mucida, E. Richard Stanley, Stephanie Dahan, Stephanie Dahan, Kara Gross Margolis, Michael David Gershon, Miriam Merad, Miriam Merad, Miriam Merad, Milena Bogunovic, Milena Bogunovic, Milena Bogunovic, Milena Bogunovic
Cell 158 300-313 2014/07
Expansion of donor-reactive host T cells in primary graft failure after allogeneic hematopoietic SCT following reduced-intensity conditioning
M. Koyama, M. Koyama, D. Hashimoto, K. Nagafuji, T. Eto, Y. Ohno, K. Aoyama, H. Iwasaki, T. Miyamoto, G. R. Hill, K. Akashi, K. Akashi, T. Teshima
Bone Marrow Transplantation 49 110-115 2014/01
Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis.
Mortha A, Chudnovskiy A, Hashimoto D, Bogunovic M, Spencer SP, Belkaid Y, Merad M.
Science. 343 1249288 2014
Interplay of host microbiota, genetic perturbations, and inflammation promotes local development of intestinal neoplasms in mice.
Bongers G, Pacer ME, Geraldino TH, Chen L, He Z, Hashimoto D, Furtado GC, Ochando J, Kelley KA, Clemente JC, Merad M, van Bakel H, Lira SA.
J Exp Med. 211 457 2014
The miR-126-VEGFR2 axis controls the innate response to pathogen-associated nucleic acids.
Agudo J, Ruzo A, Tung N, Salmon H, Leboeuf M, Hashimoto D, Becker C, Garrett-Sinha LA, Baccarini A, Merad M, Brown BD.
Nat Immunol. 15 54 2014
Central role of conventional dendritic cells in regulation of bone marrow release and survival of neutrophils.
Jiao J, Dragomir AC, Kocabayoglu P, Rahman AH, Chow A, Hashimoto D, Leboeuf M, Kraus T, Moran T, Carrasco-Avino G, Friedman SL, Merad M, Aloman C.
J Immunol. 192 3374 2014
FIP1L1 presence in FIP1L1-RARA or FIP1L1-PDGFRA differentially contributes to the pathogenesis of distinct types of leukemia.
Iwasaki J, Kondo T, Darmanin S, Ibata M, Onozawa M, Hashimoto D, Sakamoto N, Teshima T.
Ann Hematol. online 2014
Bone marrow graft-versus-host disease: evaluation of its clinical impact on disrupted hematopoiesis after allogeneic hematopoietic stem cell transplantation.
Shono Y, Shiratori S, Kosugi-Kanaya M, Ueha S, Sugita J, Shigematsu A, Kondo T, Hashimoto D, Fujimoto K, Endo T, Nishio M, Hashino S, Matsuno Y, Matsushima K, Tanaka J, Imamura M, Teshima T.
Biol Blood Marrow Transplant. 20 495 2014
Stenotrophomonas maltophilia infection during allogeneic hematopoietic stem cell transplantation: a single-center experience.
Shiratori S, Wakasa K, Okada K, Sugita J, Akizawa K, Shigematsu A, Hashimoto D, Fujimoto K, Endo T, Kondo T, Shimizu C, Hashino S, Teshima T.
Clin Transplant. 28 656 2014
Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes.
Hashimoto D, Chow A, Noizat C, Teo P, Beasley MB, Leboeuf M, Becker CD, See P, Price J, Lucas D, Greter M, Mortha A, Boyer SW, Forsberg EC, Tanaka M, van Rooijen N, García-Sastre A, Stanley ER, Ginhoux F, Frenette PS, Merad M.
Immunity. 18 792 2013
CD169+ macrophages provide a niche promoting erythropoiesis under homeostasis and stress.
Chow A, Huggins M, Ahmed J, Hashimoto D, Lucas D, Kunisaki Y, Pinho S, Leboeuf M, Noizat C, van Rooijen N, Tanaka M, Zhao ZJ, Bergman A, Merad M, Frenette PS.
Nat Med. 19 429 2013
Reciprocal expression of enteric antimicrobial proteins in intestinal graft-versus-host disease.
Eriguchi Y, Uryu H, Nakamura K, Shimoji S, Takashima S, Iwasaki H, Miyamoto T, Shimono N, Hashimoto D, Akashi K, Ayabe T, Teshima T.
Biol Blood Marrow Transplant. 19 1525 2013
Cross-presenting CD103+ dendritic cells are protected from influenza virus infection
Julie Helft, Julie Helft, Balaji Manicassamy, Balaji Manicassamy, Pierre Guermonprez, Daigo Hashimoto, Daigo Hashimoto, Aymeric Silvin, Aymeric Silvin, Judith Agudo, Judith Agudo, Brian D. Brown, Brian D. Brown, Mirco Schmolke, Mirco Schmolke, Jennifer C. Miller, Jennifer C. Miller, Marylene Leboeuf, Marylene Leboeuf, Kenneth M. Murphy, Kenneth M. Murphy, Adolfo García-Sastre, Adolfo García-Sastre, Adolfo García-Sastre, Miriam Merad, Miriam Merad, Miriam Merad
Journal of Clinical Investigation 122 4037-4047 2012/11
Antigen-presenting cell-derived complement modulates graft-versus-host disease.
Kwan WH, Hashimoto D, Paz-Artal E, Ostrow K, Greter M, Raedler H, Medof ME, Merad M, Heeger PS.
J Clin Invest. 122 2234 2012
R-Ras is required for murine dendritic cell maturation and CD4+ T-cell priming.
Singh G, Hashimoto D, Yan X, Helft J, Park PJ, Ma G, Qiao RF, Kennedy CR, Chen SH, Merad M, Chan AM.
Blood. 119 1693 2012
GM-CSF controls nonlymphoid tissue dendritic cell homeostasis but is dispensable for the differentiation of inflammatory dendritic cells.
Greter M, Helft J, Chow A, Hashimoto D, Mortha A, Agudo-Cantero J, Bogunovic M, Gautier EL, Miller J, Leboeuf M, Lu G, Aloman C, Brown BD, Pollard JW, Xiong H, Randolph GJ, Chipuk JE, Frenette PS, Merad M.
Immunity. 36 1031 2012
Deciphering the transcriptional network of the dendritic cell lineage.
Miller JC, Brown BD, Shay T, Gautier EL, Jojic V, Cohain A, Pandey G, Leboeuf M, Elpek KG, Helft J, Hashimoto D, Chow A, Price J, Greter M, Bogunovic M, Bellemare-Pelletier A, Frenette PS, Randolph GJ, Turley SJ, Merad M; Immunological Genome Consortium.
Nat Immunol. 13 888 2012
Adrenergic nerves govern circadian leukocyte recruitment to tissues.
Scheiermann C, Kunisaki Y, Lucas D, Chow A, Jang JE, Zhang D, Hashimoto D, Merad M, Frenette PS.
Immunity. 37 290 2012
Consortium biology in immunology: the perspective from the Immunological Genome Project.
Benoist C, Lanier L, Merad M, Mathis D; Immunological Genome Project.
Nat Rev Immunol. 12 734 2012
Cross-presenting CD103+ dendritic cells are protected from influenza virus infection.
Helft J, Manicassamy B, Guermonprez P, Hashimoto D, Silvin A, Agudo J, Brown BD, Schmolke M, Miller JC, Leboeuf M, Murphy KM, García-Sastre A, Merad M.
J Clin Invest. 122 4037 2012
Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche
Andrew Chow, Andrew Chow, Andrew Chow, Daniel Lucas, Daniel Lucas, Andrés Hidalgo, Andrés Hidalgo, Simón Méndez-Ferrer, Simón Méndez-Ferrer, Daigo Hashimoto, Daigo Hashimoto, Christoph Scheiermann, Christoph Scheiermann, Michela Battista, Marylene Leboeuf, Marylene Leboeuf, Colette Prophete, Colette Prophete, Nico Van Rooijen, Masato Tanaka, Miriam Merad, Miriam Merad, Paul S. Frenette, Paul S. Frenette
Journal of Experimental Medicine 208 761-771 2011/02
Pretransplant CSF-1 therapy expands recipient macrophages and ameliorates GVHD after allogeneic hematopoietic cell transplantation.
Hashimoto D, Chow A, Greter M, Saenger Y, Kwan WH, Leboeuf M, Ginhoux F, Ochando JC, Kunisaki Y, van Rooijen N, Liu C, Teshima T, Heeger PS, Stanley ER, Frenette PS, Merad M.
J Exp Med. 208 1069 2011
Dendritic cell and macrophage heterogeneity in vivo.
Hashimoto D, Miller J, Merad M.
Immunity. 35 323 2011
Harnessing dendritic cells to improve allogeneic hematopoietic cell transplantation outcome.
Hashimoto D, Merad M.
Semin Immunol. 23 50 2011
Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche.
Chow A, Lucas D, Hidalgo A, Méndez-Ferrer S, Hashimoto D, Scheiermann C, Battista M, Leboeuf M, Prophete C, van Rooijen N, Tanaka M, Merad M, Frenette PS.
J Exp Med. 208 261 2011
Alloantigen expression on non-hematopoietic cells reduces graft-versus-leukemia effects in mice.
Asakura S, Hashimoto D, Takashima S, Sugiyama H, Maeda Y, Akashi K, Tanimoto M, Teshima T.
J Clin Invest. 120 2370 2010
Monocytic suppressive cells mediate cardiovascular transplantation tolerance in mice.
Garcia MR, Ledgerwood L, Yang Y, Xu J, Lal G, Burrell B, Ma G, Hashimoto D, Li Y, Boros P, Grisotto M, van Rooijen N, Matesanz R, Tacke F, Ginhoux F, Ding Y, Chen SH, Randolph G, Merad M, Bromberg JS, Ochando JC.
J Clin Invest. 120 2486 2010
The origin and development of nonlymphoid tissue CD103+ DCs
Florent Ginhoux, Florent Ginhoux, Florent Ginhoux, Kang Liu, Julie Helft, Julie Helft, Milena Bogunovic, Milena Bogunovic, Melanie Greter, Melanie Greter, Daigo Hashimoto, Daigo Hashimoto, Jeremy Price, Jeremy Price, Na Yin, Jonathan Bromberg, Sergio A. Lira, E. Richard Stanley, Michel Nussenzweig, Michel Nussenzweig, Miriam Merad, Miriam Merad
Journal of Experimental Medicine 206 3115-3130 2009/12
Plasmacytoid dendritic cells prime alloreactive T cells to mediate graft-versus-host disease as antigen-presenting cells.
Koyama M, Hashimoto D, Aoyama K, Matsuoka K, Karube K, Niiro H, Harada M, Tanimoto M, Akashi K, Teshima T.
Blood. 113 2088 2009
Improved outcome of allogeneic bone marrow transplantation due to breastfeeding-induced tolerance to maternal antigens.
Aoyama K, Koyama M, Matsuoka K, Hashimoto D, Ichinohe T, Harada M, Akashi K, Tanimoto M, Teshima T.
Blood. 113 1829 2009
Origin of the lamina propria dendritic cell network.
Bogunovic M, Ginhoux F, Helft J, Shang L, Hashimoto D, Greter M, Liu K, Jakubzick C, Ingersoll MA, Leboeuf M, Stanley ER, Nussenzweig M, Lira SA, Randolph GJ, Merad M.
Immunity. 31 513 2009
The origin and development of nonlymphoid tissue CD103+ DCs.
Ginhoux F, Liu K, Helft J, Bogunovic M, Greter M, Hashimoto D, Price J, Yin N, Bromberg J, Lira SA, Stanley ER, Nussenzweig M, Merad M.
J Exp Med. 206 3115 2009
Sentiment sentence extraction using a hierarchical directed acyclic graph structure and a bootstrap approach
Kazutaka Shimada, Daigo Hashimoto, Tsutomu Endo
Proceedings of the 22nd Pacific Asia Conference on Language, Information and Computation, PACLIC 22 341-349 2008/12
Allogeneic hematopoietic stem cell transplantation from an HLA-haploidentical related donor based on feto-maternal tolerance
MATSUOKA Ken-ichi, AOYAMA Kazutoshi, KOYAMA Motoko, HASHIMOTO Daigo, ASAKURA Shoji, ICHINOHE Tatsuo, TANIMOTO Mitsune, TESHIMA Takanori
Journal of Okayama Medical Association 120(1) 23-28 2008/05
Donor-derived thymic-dependent T cells cause chronic graft-versus-host disease.
Sakoda Y, Hashimoto D, Asakura S, Takeuchi K, Harada M, Tanimoto M, Teshima T.
Blood. 109 1756 2007
FTY720 enhances the activation-induced apoptosis of donor T cells and modulates graft-versus-host disease.
Hashimoto D, Asakura S, Matsuoka K, Sakoda Y, Koyama M, Aoyama K, Tanimoto M, Teshima T.
Eur J Immunol. 37 271 2007
Lymphopenia-induced proliferation of donor T cells reduces their capacity for causing acute graft-versus-host disease.
Maeda Y, Tawara I, Teshima T, Liu C, Hashimoto D, Matsuoka K, Tanimoto M, Reddy P.
Exp Hematol. 35 274 2007
BONE MARROW PROCESSING IN ABO-INCOMPATIBLE BONE MARROW TRANSPLANTATION USING COBE SPECTRA CELL SEPARATOR
HENZAN Tomoko, MIYAMOTO Toshihiro, IZUMI Ken-ichi, NUMATA Akihiko, KAMEZAKI Kenjiro, YAMASAKI Satoshi, KIYOSHIMA Kumi, MIYAMOTO Kyoko, HASHIMOTO Daigo, IWASAKI Junko, IWASAKI Hiromi, NAGAFUJI Koji, HARADA Mine, INABA Shoichi, TESHIMA Takanori, AKASHI Koichi
Japanese Journal of Transfusion and Cell Therapy 52(6) 693-697 2006/12
Fetal tolerance to maternal antigens improves the outcome of allogeneic bone marrow transplantation by a CD4+CD25+ T-cell-dependent mechanism
Ken Ichi Matsuoka, Tatsuo Ichinohe, Daigo Hashimoto, Shoji Asakura, Mitsune Tanimoto, Takanori Teshima
Blood 107 404-409 2006/01
Fetal tolerance to maternal antigens improves the outcome of allogeneic bone marrow transplantation by a CD4+ CD25+ T-cell-dependent mechanism.
Matsuoka K, Ichinohe T, Hashimoto D, Asakura S, Tanimoto M, Teshima T.
Blood. 404 404 2006
Transient respiratory disturbance by granulocyte-colony-stimulating factor administration in healthy donors of allogeneic peripheral blood progenitor cell transplantation.
Yoshida I, Matsuo K, Teshima T, Hashimoto D, Tanimoto Y, Harada M, Tanimoto M.
Transfusion. 186 186 2006
Stimulation of host NKT cells by synthetic glycolipid regulates acute graft-versus-host disease by inducing Th2 polarization of donor T cells.
Hashimoto D, Asakura S, Miyake S, Yamamura T, Van Kaer L, Liu C, Tanimoto M, Teshima T.
J Immunol. 174 551 2005
Paclitaxel administered weekly in patients with docetaxel-resistant metastatic breast cancer: a single-center study.
Sawaki M, Ito Y, Hashimoto D, Mizunuma N, Takahashi S, Horikoshi N, Tada K, Kasumi F, Akiyama F, Sakamoto G, Imai T, Nakao A, Hatake K.
Tumori. 90 36 2004
Successful treatment with cyclosporin A of myelodysplastic syndrome with erythroid hypoplasia associated with t(6;8)(q15;q22).
Takata S, Kojima K, Fujii N, Kaneda K, Yoshida C, Hashimoto D, Asakura S, Shinagawa K, Tanimoto M.
Cancer Genet Cytogenet. 140 167 2003

Prizes

Clarivate Analytics Highly Cited Researchers 2016 Immunology
Clarivate Analytics Highly Cited Researchers 2017 Immunology
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Clarivate Analytics Highly Cited Researchers 2016 Immunology
Clarivate Analytics Highly Cited Researchers 2017 Immunology

Research Projects (Competitive Research Funds)

Development of a novel chronic GVHD therapy targeting macrophage-myofibroblast axis
Grants-in-Aid for Scientific Research : 基盤研究(C)
Date (from‐to) : 2017/04-2020/03 Author : Daigo Hashimoto
Reconstitution of phagocyte system after hematopoietic stem cell transplantation
Grants-in-Aid for Scientific Research : 基盤研究(C)
Date (from‐to) : 2014/04-2017/03 Author : Daigo Hashimoto
Separation of GVHD and GVL by NKT cell stimulation
Grants-in-Aid for Scientific Research : 若手研究(B)
Date (from‐to) : 2006/04-2007/03 Author : Daigo Hashimoto
Display all
Research Projects (Competitive Research Funds)close
Development of a novel chronic GVHD therapy targeting macrophage-myofibroblast axis
Grants-in-Aid for Scientific Research : 基盤研究(C)
Date (from‐to) : 2017/04-2020/03 Author : Daigo Hashimoto
Reconstitution of phagocyte system after hematopoietic stem cell transplantation
Grants-in-Aid for Scientific Research : 基盤研究(C)
Date (from‐to) : 2014/04-2017/03 Author : Daigo Hashimoto
Separation of GVHD and GVL by NKT cell stimulation
Grants-in-Aid for Scientific Research : 若手研究(B)
Date (from‐to) : 2006/04-2007/03 Author : Daigo Hashimoto

Educational Activities

Classes

Master's Thesis Research in Medical Sciences Ⅰ
Year : 2015
Master's Thesis Research in Medical Sciences Ⅱ
Year : 2015
Basic Principles of Medicine
Year : 2015
Dissertation Research in Medical Sciences Ⅰ
Year : 2015
Dissertation Research in Medical Sciences Ⅱ
Year : 2015
Master's Thesis Research in Basic Medicine Ⅰ
Year : 2015
Master's Thesis Research in Basic Medicine Ⅱ
Year : 2015
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Master's Thesis Research in Medical Sciences Ⅰ
Year : 2015
Master's Thesis Research in Medical Sciences Ⅱ
Year : 2015
Basic Principles of Medicine
Year : 2015
Dissertation Research in Medical Sciences Ⅰ
Year : 2015
Dissertation Research in Medical Sciences Ⅱ
Year : 2015
Master's Thesis Research in Basic Medicine Ⅰ
Year : 2015
Master's Thesis Research in Basic Medicine Ⅱ
Year : 2015
Display all the previous year
Classesclose
Master's Thesis Research in Medical Sciences Ⅰ
Year : 2014
Master's Thesis Research in Medical Sciences Ⅱ
Year : 2014
Basic Principles of Medicine
Year : 2014
Dissertation Research in Medical Sciences Ⅰ
Year : 2014
Dissertation Research in Medical Sciences Ⅱ
Year : 2014
Master's Thesis Research in Basic Medicine Ⅰ
Year : 2014
Master's Thesis Research in Basic Medicine Ⅱ
Year : 2014

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