Daigo Hashimotoresearchmap個人ページ

Last Updated : 2017/09/19

Basic Information

Profile

Affiliation
Hokkaido University Hospital Internal Medicine
Job TitleLecturer 
Degree
M.D.(Ph.D.)
E-mail
URL
Research funding number

Research Keywords

Hematopoietic stem cell transplantation, Graft versus host disease, Macrophage, Innate Immunity

Research Areas

Basic medicine / Immunology
Clinical internal medicine / Hematology
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Basic medicine / Immunology
Clinical internal medicine / Hematology

Career

2013
-
Today
Hokkaido University(Tenure-Track Assistant Professor)
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2013
-
Today
Hokkaido University(Tenure-Track Assistant Professor)

Academic Background

2001
-
2005
Okayama University Graduate School of Medicine and Dentistry Sciences
1991
-
1997
Okayama University Medical School
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Academic Backgroundclose
2001
-
2005
Okayama University Graduate School of Medicine and Dentistry Sciences
1991
-
1997
Okayama University Medical School

Research Activities

Papers

Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis.
Mortha A, Chudnovskiy A, Hashimoto D, Bogunovic M, Spencer SP, Belkaid Y, Merad M.
Science. 343 1249288 2014
Interplay of host microbiota, genetic perturbations, and inflammation promotes local development of intestinal neoplasms in mice.
Bongers G, Pacer ME, Geraldino TH, Chen L, He Z, Hashimoto D, Furtado GC, Ochando J, Kelley KA, Clemente JC, Merad M, van Bakel H, Lira SA.
J Exp Med. 211 457 2014
The miR-126-VEGFR2 axis controls the innate response to pathogen-associated nucleic acids.
Agudo J, Ruzo A, Tung N, Salmon H, Leboeuf M, Hashimoto D, Becker C, Garrett-Sinha LA, Baccarini A, Merad M, Brown BD.
Nat Immunol. 15 54 2014
Central role of conventional dendritic cells in regulation of bone marrow release and survival of neutrophils.
Jiao J, Dragomir AC, Kocabayoglu P, Rahman AH, Chow A, Hashimoto D, Leboeuf M, Kraus T, Moran T, Carrasco-Avino G, Friedman SL, Merad M, Aloman C.
J Immunol. 192 3374 2014
FIP1L1 presence in FIP1L1-RARA or FIP1L1-PDGFRA differentially contributes to the pathogenesis of distinct types of leukemia.
Iwasaki J, Kondo T, Darmanin S, Ibata M, Onozawa M, Hashimoto D, Sakamoto N, Teshima T.
Ann Hematol. online 2014
Bone marrow graft-versus-host disease: evaluation of its clinical impact on disrupted hematopoiesis after allogeneic hematopoietic stem cell transplantation.
Shono Y, Shiratori S, Kosugi-Kanaya M, Ueha S, Sugita J, Shigematsu A, Kondo T, Hashimoto D, Fujimoto K, Endo T, Nishio M, Hashino S, Matsuno Y, Matsushima K, Tanaka J, Imamura M, Teshima T.
Biol Blood Marrow Transplant. 20 495 2014
Stenotrophomonas maltophilia infection during allogeneic hematopoietic stem cell transplantation: a single-center experience.
Shiratori S, Wakasa K, Okada K, Sugita J, Akizawa K, Shigematsu A, Hashimoto D, Fujimoto K, Endo T, Kondo T, Shimizu C, Hashino S, Teshima T.
Clin Transplant. 28 656 2014
Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes.
Hashimoto D, Chow A, Noizat C, Teo P, Beasley MB, Leboeuf M, Becker CD, See P, Price J, Lucas D, Greter M, Mortha A, Boyer SW, Forsberg EC, Tanaka M, van Rooijen N, García-Sastre A, Stanley ER, Ginhoux F, Frenette PS, Merad M.
Immunity. 18 792 2013
CD169+ macrophages provide a niche promoting erythropoiesis under homeostasis and stress.
Chow A, Huggins M, Ahmed J, Hashimoto D, Lucas D, Kunisaki Y, Pinho S, Leboeuf M, Noizat C, van Rooijen N, Tanaka M, Zhao ZJ, Bergman A, Merad M, Frenette PS.
Nat Med. 19 429 2013
Reciprocal expression of enteric antimicrobial proteins in intestinal graft-versus-host disease.
Eriguchi Y, Uryu H, Nakamura K, Shimoji S, Takashima S, Iwasaki H, Miyamoto T, Shimono N, Hashimoto D, Akashi K, Ayabe T, Teshima T.
Biol Blood Marrow Transplant. 19 1525 2013
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Papersclose
Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis.
Mortha A, Chudnovskiy A, Hashimoto D, Bogunovic M, Spencer SP, Belkaid Y, Merad M.
Science. 343 1249288 2014
Interplay of host microbiota, genetic perturbations, and inflammation promotes local development of intestinal neoplasms in mice.
Bongers G, Pacer ME, Geraldino TH, Chen L, He Z, Hashimoto D, Furtado GC, Ochando J, Kelley KA, Clemente JC, Merad M, van Bakel H, Lira SA.
J Exp Med. 211 457 2014
The miR-126-VEGFR2 axis controls the innate response to pathogen-associated nucleic acids.
Agudo J, Ruzo A, Tung N, Salmon H, Leboeuf M, Hashimoto D, Becker C, Garrett-Sinha LA, Baccarini A, Merad M, Brown BD.
Nat Immunol. 15 54 2014
Central role of conventional dendritic cells in regulation of bone marrow release and survival of neutrophils.
Jiao J, Dragomir AC, Kocabayoglu P, Rahman AH, Chow A, Hashimoto D, Leboeuf M, Kraus T, Moran T, Carrasco-Avino G, Friedman SL, Merad M, Aloman C.
J Immunol. 192 3374 2014
FIP1L1 presence in FIP1L1-RARA or FIP1L1-PDGFRA differentially contributes to the pathogenesis of distinct types of leukemia.
Iwasaki J, Kondo T, Darmanin S, Ibata M, Onozawa M, Hashimoto D, Sakamoto N, Teshima T.
Ann Hematol. online 2014
Bone marrow graft-versus-host disease: evaluation of its clinical impact on disrupted hematopoiesis after allogeneic hematopoietic stem cell transplantation.
Shono Y, Shiratori S, Kosugi-Kanaya M, Ueha S, Sugita J, Shigematsu A, Kondo T, Hashimoto D, Fujimoto K, Endo T, Nishio M, Hashino S, Matsuno Y, Matsushima K, Tanaka J, Imamura M, Teshima T.
Biol Blood Marrow Transplant. 20 495 2014
Stenotrophomonas maltophilia infection during allogeneic hematopoietic stem cell transplantation: a single-center experience.
Shiratori S, Wakasa K, Okada K, Sugita J, Akizawa K, Shigematsu A, Hashimoto D, Fujimoto K, Endo T, Kondo T, Shimizu C, Hashino S, Teshima T.
Clin Transplant. 28 656 2014
Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes.
Hashimoto D, Chow A, Noizat C, Teo P, Beasley MB, Leboeuf M, Becker CD, See P, Price J, Lucas D, Greter M, Mortha A, Boyer SW, Forsberg EC, Tanaka M, van Rooijen N, García-Sastre A, Stanley ER, Ginhoux F, Frenette PS, Merad M.
Immunity. 18 792 2013
CD169+ macrophages provide a niche promoting erythropoiesis under homeostasis and stress.
Chow A, Huggins M, Ahmed J, Hashimoto D, Lucas D, Kunisaki Y, Pinho S, Leboeuf M, Noizat C, van Rooijen N, Tanaka M, Zhao ZJ, Bergman A, Merad M, Frenette PS.
Nat Med. 19 429 2013
Reciprocal expression of enteric antimicrobial proteins in intestinal graft-versus-host disease.
Eriguchi Y, Uryu H, Nakamura K, Shimoji S, Takashima S, Iwasaki H, Miyamoto T, Shimono N, Hashimoto D, Akashi K, Ayabe T, Teshima T.
Biol Blood Marrow Transplant. 19 1525 2013
Antigen-presenting cell-derived complement modulates graft-versus-host disease.
Kwan WH, Hashimoto D, Paz-Artal E, Ostrow K, Greter M, Raedler H, Medof ME, Merad M, Heeger PS.
J Clin Invest. 122 2234 2012
R-Ras is required for murine dendritic cell maturation and CD4+ T-cell priming.
Singh G, Hashimoto D, Yan X, Helft J, Park PJ, Ma G, Qiao RF, Kennedy CR, Chen SH, Merad M, Chan AM.
Blood. 119 1693 2012
GM-CSF controls nonlymphoid tissue dendritic cell homeostasis but is dispensable for the differentiation of inflammatory dendritic cells.
Greter M, Helft J, Chow A, Hashimoto D, Mortha A, Agudo-Cantero J, Bogunovic M, Gautier EL, Miller J, Leboeuf M, Lu G, Aloman C, Brown BD, Pollard JW, Xiong H, Randolph GJ, Chipuk JE, Frenette PS, Merad M.
Immunity. 36 1031 2012
Deciphering the transcriptional network of the dendritic cell lineage.
Miller JC, Brown BD, Shay T, Gautier EL, Jojic V, Cohain A, Pandey G, Leboeuf M, Elpek KG, Helft J, Hashimoto D, Chow A, Price J, Greter M, Bogunovic M, Bellemare-Pelletier A, Frenette PS, Randolph GJ, Turley SJ, Merad M; Immunological Genome Consortium.
Nat Immunol. 13 888 2012
Adrenergic nerves govern circadian leukocyte recruitment to tissues.
Scheiermann C, Kunisaki Y, Lucas D, Chow A, Jang JE, Zhang D, Hashimoto D, Merad M, Frenette PS.
Immunity. 37 290 2012
Consortium biology in immunology: the perspective from the Immunological Genome Project.
Benoist C, Lanier L, Merad M, Mathis D; Immunological Genome Project.
Nat Rev Immunol. 12 734 2012
Cross-presenting CD103+ dendritic cells are protected from influenza virus infection.
Helft J, Manicassamy B, Guermonprez P, Hashimoto D, Silvin A, Agudo J, Brown BD, Schmolke M, Miller JC, Leboeuf M, Murphy KM, García-Sastre A, Merad M.
J Clin Invest. 122 4037 2012
Pretransplant CSF-1 therapy expands recipient macrophages and ameliorates GVHD after allogeneic hematopoietic cell transplantation.
Hashimoto D, Chow A, Greter M, Saenger Y, Kwan WH, Leboeuf M, Ginhoux F, Ochando JC, Kunisaki Y, van Rooijen N, Liu C, Teshima T, Heeger PS, Stanley ER, Frenette PS, Merad M.
J Exp Med. 208 1069 2011
Dendritic cell and macrophage heterogeneity in vivo.
Hashimoto D, Miller J, Merad M.
Immunity. 35 323 2011
Harnessing dendritic cells to improve allogeneic hematopoietic cell transplantation outcome.
Hashimoto D, Merad M.
Semin Immunol. 23 50 2011
Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche.
Chow A, Lucas D, Hidalgo A, Méndez-Ferrer S, Hashimoto D, Scheiermann C, Battista M, Leboeuf M, Prophete C, van Rooijen N, Tanaka M, Merad M, Frenette PS.
J Exp Med. 208 261 2011
Alloantigen expression on non-hematopoietic cells reduces graft-versus-leukemia effects in mice.
Asakura S, Hashimoto D, Takashima S, Sugiyama H, Maeda Y, Akashi K, Tanimoto M, Teshima T.
J Clin Invest. 120 2370 2010
Monocytic suppressive cells mediate cardiovascular transplantation tolerance in mice.
Garcia MR, Ledgerwood L, Yang Y, Xu J, Lal G, Burrell B, Ma G, Hashimoto D, Li Y, Boros P, Grisotto M, van Rooijen N, Matesanz R, Tacke F, Ginhoux F, Ding Y, Chen SH, Randolph G, Merad M, Bromberg JS, Ochando JC.
J Clin Invest. 120 2486 2010
Plasmacytoid dendritic cells prime alloreactive T cells to mediate graft-versus-host disease as antigen-presenting cells.
Koyama M, Hashimoto D, Aoyama K, Matsuoka K, Karube K, Niiro H, Harada M, Tanimoto M, Akashi K, Teshima T.
Blood. 113 2088 2009
Improved outcome of allogeneic bone marrow transplantation due to breastfeeding-induced tolerance to maternal antigens.
Aoyama K, Koyama M, Matsuoka K, Hashimoto D, Ichinohe T, Harada M, Akashi K, Tanimoto M, Teshima T.
Blood. 113 1829 2009
Origin of the lamina propria dendritic cell network.
Bogunovic M, Ginhoux F, Helft J, Shang L, Hashimoto D, Greter M, Liu K, Jakubzick C, Ingersoll MA, Leboeuf M, Stanley ER, Nussenzweig M, Lira SA, Randolph GJ, Merad M.
Immunity. 31 513 2009
The origin and development of nonlymphoid tissue CD103+ DCs.
Ginhoux F, Liu K, Helft J, Bogunovic M, Greter M, Hashimoto D, Price J, Yin N, Bromberg J, Lira SA, Stanley ER, Nussenzweig M, Merad M.
J Exp Med. 206 3115 2009
Donor-derived thymic-dependent T cells cause chronic graft-versus-host disease.
Sakoda Y, Hashimoto D, Asakura S, Takeuchi K, Harada M, Tanimoto M, Teshima T.
Blood. 109 1756 2007
FTY720 enhances the activation-induced apoptosis of donor T cells and modulates graft-versus-host disease.
Hashimoto D, Asakura S, Matsuoka K, Sakoda Y, Koyama M, Aoyama K, Tanimoto M, Teshima T.
Eur J Immunol. 37 271 2007
Lymphopenia-induced proliferation of donor T cells reduces their capacity for causing acute graft-versus-host disease.
Maeda Y, Tawara I, Teshima T, Liu C, Hashimoto D, Matsuoka K, Tanimoto M, Reddy P.
Exp Hematol. 35 274 2007
Fetal tolerance to maternal antigens improves the outcome of allogeneic bone marrow transplantation by a CD4+ CD25+ T-cell-dependent mechanism.
Matsuoka K, Ichinohe T, Hashimoto D, Asakura S, Tanimoto M, Teshima T.
Blood. 404 404 2006
Transient respiratory disturbance by granulocyte-colony-stimulating factor administration in healthy donors of allogeneic peripheral blood progenitor cell transplantation.
Yoshida I, Matsuo K, Teshima T, Hashimoto D, Tanimoto Y, Harada M, Tanimoto M.
Transfusion. 186 186 2006
Stimulation of host NKT cells by synthetic glycolipid regulates acute graft-versus-host disease by inducing Th2 polarization of donor T cells.
Hashimoto D, Asakura S, Miyake S, Yamamura T, Van Kaer L, Liu C, Tanimoto M, Teshima T.
J Immunol. 174 551 2005
Paclitaxel administered weekly in patients with docetaxel-resistant metastatic breast cancer: a single-center study.
Sawaki M, Ito Y, Hashimoto D, Mizunuma N, Takahashi S, Horikoshi N, Tada K, Kasumi F, Akiyama F, Sakamoto G, Imai T, Nakao A, Hatake K.
Tumori. 90 36 2004
Successful treatment with cyclosporin A of myelodysplastic syndrome with erythroid hypoplasia associated with t(6;8)(q15;q22).
Takata S, Kojima K, Fujii N, Kaneda K, Yoshida C, Hashimoto D, Asakura S, Shinagawa K, Tanimoto M.
Cancer Genet Cytogenet. 140 167 2003

Research Projects (Competitive Research Funds)

Reconstitution of phagocyte system after hematopoietic stem cell transplantation
Grants-in-Aid for Scientific Research : 基盤研究(C)
Date (from‐to) : 2014/04-2017/03 Author : Daigo Hashimoto
Separation of GVHD and GVL by NKT cell stimulation
Grants-in-Aid for Scientific Research : 若手研究(B)
Date (from‐to) : 2006/04-2007/03 Author : Daigo Hashimoto
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Research Projects (Competitive Research Funds)close
Reconstitution of phagocyte system after hematopoietic stem cell transplantation
Grants-in-Aid for Scientific Research : 基盤研究(C)
Date (from‐to) : 2014/04-2017/03 Author : Daigo Hashimoto
Separation of GVHD and GVL by NKT cell stimulation
Grants-in-Aid for Scientific Research : 若手研究(B)
Date (from‐to) : 2006/04-2007/03 Author : Daigo Hashimoto

Educational Activities

Classes

Master's Thesis Research in Medical Sciences Ⅰ
Year : 2015
Master's Thesis Research in Medical Sciences Ⅱ
Year : 2015
Basic Principles of Medicine
Year : 2015
Dissertation Research in Medical Sciences Ⅰ
Year : 2015
Dissertation Research in Medical Sciences Ⅱ
Year : 2015
Master's Thesis Research in Basic Medicine Ⅰ
Year : 2015
Master's Thesis Research in Basic Medicine Ⅱ
Year : 2015
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Master's Thesis Research in Medical Sciences Ⅰ
Year : 2015
Master's Thesis Research in Medical Sciences Ⅱ
Year : 2015
Basic Principles of Medicine
Year : 2015
Dissertation Research in Medical Sciences Ⅰ
Year : 2015
Dissertation Research in Medical Sciences Ⅱ
Year : 2015
Master's Thesis Research in Basic Medicine Ⅰ
Year : 2015
Master's Thesis Research in Basic Medicine Ⅱ
Year : 2015
Display all the previous year
Classesclose
Master's Thesis Research in Medical Sciences Ⅰ
Year : 2014
Master's Thesis Research in Medical Sciences Ⅱ
Year : 2014
Basic Principles of Medicine
Year : 2014
Dissertation Research in Medical Sciences Ⅰ
Year : 2014
Dissertation Research in Medical Sciences Ⅱ
Year : 2014
Master's Thesis Research in Basic Medicine Ⅰ
Year : 2014
Master's Thesis Research in Basic Medicine Ⅱ
Year : 2014

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