KUGE Yujiresearchmap個人ページ

Last Updated : 2018/10/04

Basic Information

Profile

Affiliation
Central Institute of Isotope Science
Job TitleProfessor 
Degree
Pharmaceutical Sciences(Kyoto University)
E-mail
URL
Research funding number70321958

Research Keywords

tumor, glucose, inflammation, insulin, Radiopharmaceutical, Molecular Imaging, Nuclear Medicine, Pathofunctional Bioanalysis

Research Areas

Pharmacy / Physical pharmacy
Clinical internal medicine / Radiation science
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Pharmacy / Physical pharmacy
Clinical internal medicine / Radiation science

Academic Background

-
1987
Kyoto University Division of Pharmacy and Biomedicinal Sciences
-
1985
Kyoto University
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Academic Backgroundclose
-
1987
Kyoto University Division of Pharmacy and Biomedicinal Sciences
-
1985
Kyoto University

Academic Societies

Japanese radioactive medicine science society
Japanese Society for Molecular Imaging
JAPANESE SOCIETY OF RADIATION SAFETY MANAGEMENT
The American Society of Nuclear Medicine
Cerebral Blood Flow and Metabolism
THE JAPANESE PHARMACOLOGICAL SOCIETY
THE PHARMACEUTICAL SOCIETY OF JAPAN
THE JAPANESE SOCIETY OF NUCLEAR MEDICINE
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Japanese radioactive medicine science society
Japanese Society for Molecular Imaging
JAPANESE SOCIETY OF RADIATION SAFETY MANAGEMENT
The American Society of Nuclear Medicine
Cerebral Blood Flow and Metabolism
THE JAPANESE PHARMACOLOGICAL SOCIETY
THE PHARMACEUTICAL SOCIETY OF JAPAN
THE JAPANESE SOCIETY OF NUCLEAR MEDICINE

Research Activities

Papers

Relationship between intelligence quotient (IQ) and cerebral metabolic rate of oxygen in patients with neurobehavioural disability after traumatic brain injury.
Abiko K, Shiga T, Katoh C, Hirata K, Kuge Y, Kobayashi K, Ikeda S, Ikoma K
Brain Inj inpress 2018
A novel PET probe “[18F]DiFA” accumulates in hypoxic region via glutathione conjugation following reductive metabolism.
Shimizu Y, Zhao S, Yasui H, Nishijima K, Matsumoto H, Shiga T, Tamaki N, Ogawa M, Kuge Y
Mol Imaging Biol inpress 2018
Anti PD-1 treatment increases [18F]FDG uptake by cancer cells in a mouse B16F10 melanoma model.
Tomita M, Yasui H, Higashikawa K, Nakajima K, Takakura H, Shiga T, Kuge Y, Ogawa M
EJNMMI Res 8(1) 82 2018
[18F]DPA-714 PET imaging shows immunomodulatory effect of intravenous administration of bone marrow stromal cells after transient focal ischemia.
Tan C, Zhao S, Higashikawa K, Wang Z, Kawabori M, Abumiya T, Nakayama N, Kazumata K, Ukon N, Yasui H, Tamaki N, Kuge Y, Shichinohe H, Houkin K
EJNMMI Res 8(1) 35 2018
Measurement of Iodine-Derived Contamination in L-[11C]Methionine Injection.
Komatsu Y, Nishijima K, Oomagari S, Kanai Y, Naka S, Higashikawa K, Ebita Y, Shiga T, Hatazawa J, Tamaki N, Kuge Y
RADIOISOTOPES 67 75-83 2018
In Vitro Uptake and Metabolism of [14C]Acetate in Rabbit Atherosclerotic Arteries: Biological Basis for Atherosclerosis Imaging with [11C]Acetate.
Yamasaki K, Yamashita A, Zhao Y, Shimizu Y, Nishii R, Kawai K, Tamaki N, Zhao S, Asada Y, Kuge Y
Nucl Med Biol 56 21-25 2018
FMISO accumulation in tumor is dependent on glutathione conjugation capacity in addition to hypoxic state
Masaki Y, Shimizu Y, Yoshioka T, Nishijima K, Zhao S, Higashino K, Numata Y, Tamaki N, Kuge Y
Ann Nucl Med 31 596-604 2017
Local relapse of nasopharyngeal cancer and Voxel-based analysis of FMISO uptake using PET with semiconductor detectors
Nishikawa Y, Yasuda K, Okamoto S, Ito YM, Onimaru R, Shiga T, Tsuchiya K, Watanabe S, Takeuchi W, Kuge Y, Peng H, Tamaki N, Shirato H
Radiation Oncology 12 148 2017
111In-DTPA-d-Phe-1-Asp0-d-Phe1-octreotide exhibits higher tumor accumulation and lower renal radioactivity than 111In-DTPA-d-Phe1-octreotide
Oshima N, Akizawa H, Kitaura H, Kawashima H, Zhao S, Zhao Y, Nishijima KI, Kitamura Y, Arano Y, Kuge Y, Ohkura K
Nucl Med Biol 54 18-26 2017
Immunoglobulin G (IgG)-Based Imaging Probe Accumulates in M1 Macrophage-Infiltrated Atherosclerotic Plaques Independent of IgG Target Molecule Expression
Shimizu Y, Hanzawa H, Zhao Y, Fukura S, Nishijima KI, Sakamoto T, Zhao S, Tamaki N, Ogawa M, Kuge Y
Mol Imaging Biol 19(4) 531-539 2017
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Relationship between intelligence quotient (IQ) and cerebral metabolic rate of oxygen in patients with neurobehavioural disability after traumatic brain injury.
Abiko K, Shiga T, Katoh C, Hirata K, Kuge Y, Kobayashi K, Ikeda S, Ikoma K
Brain Inj inpress 2018
A novel PET probe “[18F]DiFA” accumulates in hypoxic region via glutathione conjugation following reductive metabolism.
Shimizu Y, Zhao S, Yasui H, Nishijima K, Matsumoto H, Shiga T, Tamaki N, Ogawa M, Kuge Y
Mol Imaging Biol inpress 2018
Anti PD-1 treatment increases [18F]FDG uptake by cancer cells in a mouse B16F10 melanoma model.
Tomita M, Yasui H, Higashikawa K, Nakajima K, Takakura H, Shiga T, Kuge Y, Ogawa M
EJNMMI Res 8(1) 82 2018
[18F]DPA-714 PET imaging shows immunomodulatory effect of intravenous administration of bone marrow stromal cells after transient focal ischemia.
Tan C, Zhao S, Higashikawa K, Wang Z, Kawabori M, Abumiya T, Nakayama N, Kazumata K, Ukon N, Yasui H, Tamaki N, Kuge Y, Shichinohe H, Houkin K
EJNMMI Res 8(1) 35 2018
Measurement of Iodine-Derived Contamination in L-[11C]Methionine Injection.
Komatsu Y, Nishijima K, Oomagari S, Kanai Y, Naka S, Higashikawa K, Ebita Y, Shiga T, Hatazawa J, Tamaki N, Kuge Y
RADIOISOTOPES 67 75-83 2018
In Vitro Uptake and Metabolism of [14C]Acetate in Rabbit Atherosclerotic Arteries: Biological Basis for Atherosclerosis Imaging with [11C]Acetate.
Yamasaki K, Yamashita A, Zhao Y, Shimizu Y, Nishii R, Kawai K, Tamaki N, Zhao S, Asada Y, Kuge Y
Nucl Med Biol 56 21-25 2018
FMISO accumulation in tumor is dependent on glutathione conjugation capacity in addition to hypoxic state
Masaki Y, Shimizu Y, Yoshioka T, Nishijima K, Zhao S, Higashino K, Numata Y, Tamaki N, Kuge Y
Ann Nucl Med 31 596-604 2017
Local relapse of nasopharyngeal cancer and Voxel-based analysis of FMISO uptake using PET with semiconductor detectors
Nishikawa Y, Yasuda K, Okamoto S, Ito YM, Onimaru R, Shiga T, Tsuchiya K, Watanabe S, Takeuchi W, Kuge Y, Peng H, Tamaki N, Shirato H
Radiation Oncology 12 148 2017
111In-DTPA-d-Phe-1-Asp0-d-Phe1-octreotide exhibits higher tumor accumulation and lower renal radioactivity than 111In-DTPA-d-Phe1-octreotide
Oshima N, Akizawa H, Kitaura H, Kawashima H, Zhao S, Zhao Y, Nishijima KI, Kitamura Y, Arano Y, Kuge Y, Ohkura K
Nucl Med Biol 54 18-26 2017
Immunoglobulin G (IgG)-Based Imaging Probe Accumulates in M1 Macrophage-Infiltrated Atherosclerotic Plaques Independent of IgG Target Molecule Expression
Shimizu Y, Hanzawa H, Zhao Y, Fukura S, Nishijima KI, Sakamoto T, Zhao S, Tamaki N, Ogawa M, Kuge Y
Mol Imaging Biol 19(4) 531-539 2017
18F-Fluoromisonidazole positron emission tomography (FMISO-PET) may reflect hypoxia and cell proliferation activity in oral squamous cell carcinoma
Sato J, Kitagawa Y, Watanabe S, Asaka T, Ohga N, Hirata K, Okamoto S, Shiga T, Shindoh M, Kuge Y, Tamaki N
Oral Surg Oral Med Oral Pathol Oral Radiol 124(3) 261-270 2017
Changes in tumor oxygen state after sorafenib therapy evaluated by 18F-fluoromisonidazole hypoxia imaging of renal cell carcinoma xenograft
Yu W, Zhao S, Zhao Y, Fatema CN, Murakami M, Nishijima KI, Kitagawa Y, Tamaki N, Kuge Y
Oncology Lett 14 2341-2346 2017
Altered glucose metabolism and hypoxic response in alloxan-induced diabetic atherosclerosis in rabbits
Matsuura Y, Yamashita A, Zhao Y, Iwakiri T, Yamasaki K, Sugita C, Koshimoto C, Kitamura K, Kawai K, Tamaki N, Zhao S, Kuge Y, Asada Y
PLoS One 12(4) e0175976 2017
Hypoxic glucose metabolism in glioblastoma as a potential prognostic factor
Toyonaga T, Yamaguchi S, Hirata K, Kobayashi K, Manabe O, Watanabe S, Terasaka S, Kobayashi H, Hattori N, Shiga T, Kuge Y, Tanaka S, Ito YM, Tamaki N
Eur J Nucl Med Mol Imaging 44(4) 611-619 2017
I-123 iomazenil single photon emission computed tomography for detecting loss of neuronal integrity in patients with traumatic brain injury
Abiko K, Ikoma K, Shiga T, Katoh C, Hirata K, Kuge Y, Kobayashi K, Tamaki N
EJNMMI Res 7(1) 28 2017
Redesign of negatively charged 111In-DTPA-octreotide derivative to reduce renal radioactivity
Oshima N, Akizawa H, Kawashima H, Zhao S, Zhao Y, Nishijima KI, Kitamura Y, Arano Y, Kuge Y, Ohkura K
Nucl Med Biol 48 16-25 2017
Imaging mass spectrometry reveals acyl-chain- and region-specific sphingolipid metabolism in the kidneys of sphingomyelin synthase 2-deficient mice
Sugimoto M, Wakabayashi M, Shimizu Y, Yoshioka T, Higashino K, Numata Y, Okuda T, Zhao S, Sakai S, Igarashi Y, Kuge
PLoS One 11(3) e0152191 2016
Characterization of the role of sphingomyelin synthase 2 in glucose metabolism in whole-body and peripheral tissues in mice
Sugimoto M, Shimizu Y, Zhao S, Ukon N, Nishijima K, Wakabayashi M, Yoshioka T, Higashino K, Numata Y, Okuda T, Tamaki N, Hanamatsu H, Igarashi Y, Kuge Y
Biochim Biophys Acta 1861(8 Pt A) 688-702 2016
18F-fluoromisonidazole positron emission tomography can predict pathological necrosis of brain tumors
Toyonaga T, Hirata K, Yamaguchi S, Hatanaka KC, Yuzawa S, Manabe O, Kobayashi K, Watanabe S, Shiga T, Terasaka S, Kobayashi H, Kuge Y, Tamaki N
Eur J Nucl Med Mol Imaging 43(8) 1469-1476 2016
Continuous-Flow Synthesis of N-Succinimidyl 4-[18F]fluorobenzoate Using a Single Microfluidic Chip
Kimura H, Tomatsu K, Saiki H, Arimitsu K, Ono M, Kawashima H, Iwata R, Nakanishi H, Ozeki E, Kuge Y, Saji H
PLoS One 11(7) e0159303 2016
The Thymidine Phosphorylase Imaging Agent 123I-IIMU Predicts the Efficacy of Capecitabine
Kobashi N, Matsumoto H, Zhao S, Meike S, Okumura Y, Abe T, Akizawa H, Ohkura K, Ken-Ichi N, Tamaki N, Kuge Y
J Nucl Med 57(8) 1276-1281 2016
Imaging Mass Spectrometry Revealed the Accumulation Characteristics of the 2-Nitroimidazole-Based Agent "Pimonidazole" in Hypoxia
Masaki Y, Shimizu Y, Yoshioka T, Feng F, Zhao S, Higashino K, Numata Y, Kuge Y
PLoS One 11(8) e0161639 2016
Optimization of helical acquisition parameters to preserve uniformity of mouse whole body using multipinhole collimator in single-photon emission computed tomography
Ukon N, Kubo N, Ishikawa M, Zhao S, Tamaki N, Kuge Y
Results in Physics 6 659-663 2016
The reoxygenation of hypoxia and the reduction of glucose metabolism in head and neck cancer by fractionated radiotherapy with intensity-modulated radiation therapy
Okamoto S, Shiga T, Yasuda K, Watanabe S, Hirata K, Nishijima K, Magota K, Kasai K, Onimaru R, Tuchiya K, Kuge Y, Shirato H, Tamaki N
Eur J Nucl Med Mol Imaging 43(12) 2147-2154 2016
Dynamic PET evaluation of elevated FLT level after sorafenib treatment in mice bearing human renal cell carcinoma xenograft
Ukon N, Zhao S, Yu W, Shimizu Y, Nishijima KI, Kubo N, Kitagawa Y, Tamaki N, Higashikawa K, Yasui H, Kuge Y
EJNMMI Res 6(1) 90 2016
Irbesartan attenuates atherosclerosis in Watanabe Heritable Hyperlipidemic rabbits: Noninvasive imaging of inflammation by 18F-FDG PET
Zhao Y, Fukao K, Zhao S, Watanabe A, Hamada T, Yamasaki K, Shimizu Y, Kubo N, Ukon N, Nakano T, Tamaki N, Kuge Y
Mol Imaging 14(0) 1-8 2015
Radiolabeled BMIPP for imaging hepatic fatty acid metabolism: Evaluation of hepatic distribution and metabolism in mice at various metabolic status induced by fasting in comparison with palmitic acid
Yamasaki K, Zhao S, Nishimura M, Zhao Y, Yu W, Shimizu Y, Nishijima K, Tamaki N, Takeda H, Kuge Y
Mol Imaging 14(0) 1-11 2015
Differentiation of malignant tumours from granulomas by using dynamic [18F]-fluoro-L-α-methyltyrosine positron emission tomography
Yamaguchi A, Hanaoka H, Fujisawa Y, Zhao S, Suzue K, Morita A, Tominaga H, Higuchi T, Hisaeda H, Tsushima Y, Kuge Y, Iida Y
EJNMMI Res 5 29 2015
Application of Microreactor to the Preparation of C-11-Labeled Compounds via O-[(11)C]Methylation with [(11)C]CH3I: Rapid Synthesis of [(11)C]Raclopride
Kawashima H, Kimura H, Nakaya Y, Tomatsu K, Arimitsu K, Nakanishi H, Ozeki E, Kuge Y, Saji H
Chem Pharm Bull (Tokyo) 63(9) 737-740 2015
Histological analyses by matrix-assisted laser desorption/ionization-imaging mass spectrometry reveal differential localization of sphingomyelin molecular species regulated by particular ceramide synthase in mouse brains
Sugimoto M, Shimizu Y, Yoshioka T, Wakabayashi M, Tanaka Y, Higashino H, Numata Y, Sakai S, Kihara A, Igarashi Y, Kuge Y
Biochim Biophys Acta 1851(12) 1554-1565 2015
The accumulation mechanism of the hypoxia imaging probe "FMISO" by imaging mass spectrometry: possible involvement of low-molecular metabolites
Masaki Y, Shimizu Y, Yoshioka T, Tanaka Y, Nishijima K, Zhao S, Higashino K, Sakamoto S, Numata Y, Yamaguchi Y, Tamaki N, Kuge Y
Sci Rep 5 16802 2015
Combined plasma and tissue proteomic study of atherogenic model mouse: approach to eucidate mlecular dterminants in aherosclerosis dvelopment
Hanzawa H, Sakamoto T, Kaneko A, Manri N, Zhao Y, Zhao S, Tamaki N, Kuge Y
J Proteome Res 14(10) 4257-4269 2015
Relationship between biodistribution of a novel thymidine phosphorylase (TP) imaging probe and TP expression levels in normal mice
Zhao S, Li H, Nishijima K, Zhao Y, Akizawa H, Shimizu Y, Ohkura K, Tamaki N, Kuge Y
Ann Nucl Med 29(7) 582-587 2015
Prognostic value of volume-based measurements on (11)C-methionine PET in glioma patients
Kobayashi K, Hirata K, Yamaguchi S, Manabe O, Terasaka S, Kobayashi H, Shiga T, Hattori N, Tanaka S, Kuge Y, Tamaki N
Eur J Nucl Med Mol Imaging 42(7) 1071-1080 2015
Oli-godendroglial component complicates the prediction of tumour grading with metabolic imaging
Manabe O, Hattori N, Yamaguchi S, Hirata K, Kobayashi K, Terasaka S, Kobayashi H, Motegi H, Shiga T, Magota K, Oyama-Manabe N, Nishijima K, Kuge Y, Tamaki N
Eur J Nucl Med Mol Imaging 42(6) 896-904 2015
Regulatory effect of interleukin-4 in the innate inflammatory response to Rhodococcus aurantiacus infection in mice
Yimin, Kohanawa M, Zhao S, Li M, Kuge Y, Tamaki N, Watanabe M
J Interferon Cytokine Res 35(3) 222-231 2015
Micelle-based Activatable Probe for in vivo Near-Infrared Optical Imaging of Cancer Biomolecules. Nanomedicine
Shimizu Y, Temma T, Hara I, Makino A, Yamahara R, Ozeki EI, Ono M, Saji H
Nanotechnology, Biology and Medicine 10 187-195 2014
Investigation of cyanine dyes for in vivo optical imaging of altered mitochondrial membrane potential in tumors
Onoe S, Temma T, Shimizu Y, Ono M, Saji H
Cancer Medicine 3 775-786 2014
In vivo Imaging of Membrane Type-1 Matrix Metalloproteinase with a Novel Activatable Near-Infrared Fluorescence Probe
Shimizu Y, Temma T, Hara I, Makino A, Kondo N, Ozeki EI, Ono M, Saji H
Cancer Science 105 1056-1062 2014
Collimator for variable sensitivity and spatial resolution without the need for exchange
Kubo N, Tsuchiya K, Shiga T, Kojima S, Suzuki A, Ueno Y, Kobayashi K, Tamaki N
IEEE Trans Nucl Sci 61(5) 2489-2493 2014
Dual tracer evaluation of dynamic changes in intratumoral hypoxic and proliferative states after radiotherapy of human head and neck cancer zerografts using radiolabaled FMISO and FLT.
Fatema CN, Zhao S, Yu W, Nishijima K, Yasuda K, Kitagawa Y, Tamaki N, Kuge Y
BMC Cancer 14(1) 692 2014
Evaluation of delineation of image details in semiconductor PET utilizing the normalized mutual information technique
Kubo N, Hirata K, Matsuzaki K, Morimoto Y, Takeuchi W, Hattori N, Shiga T, Kuge Y, Tamaki N
Nuclear Medicine Communications 35(6) 677-682 2014
Design, synthesis and biological evaluation of negatively charged 111In-DTPA-octreotide derivatives.
Oshima N, Akizawa H, Zhao S, Zhao Y, Nishijima KI, Kitamura Y, Arano Y, Kuge Y, Ohkura K
Bioorg Med Chem. 22(4) 1377-82 2014
A simple and rapid method for standard preparation of gas phase extract of cigarette smoke.
Higashi T, Mai Y, Noya Y, Horinouchi T, Terada K, Hoshi A, Nepal P, Harada T, Horiguchi M, Hatate C, Kuge Y, Miwa S
PLOS One 9(9) e107856 2014
Suppressive effects of irbesartan on inflammation and apoptosis in atherosclerotic plaques of apoE-/- mice: molecular imaging with 14C-FDG and 99mTc-annexin A5.
Zhao Y, Watanabe A, Zhao S, Kobayashi T, Fukao K, Tanaka Y, Nakano T, Yoshida T, Takemoto H, Tamaki N, Kuge Y
PLOS One 9(2) e89338 2014
Increased metabolite levels of glycolysis and pentose phosphate pathway in rabbit atherosclerotic arteries and hypoxic macrophage.
Yamashita A, Zhao Y, Matsuura Y, Yamasaki K, Moriguchi-Goto S, Sugita C, Iwakiri T, Okuyama N, Koshimoto C, Kawai K, Tamaki N, Zhao S, Kuge Y, Asada Y
PLoS One 9(1) e86426 2014
[(18)F]fluoromisonidazole and a New PET System With Semiconductor Detectors and a Depth of Interaction System for Intensity Modulated Radiation Therapy for Nasopharyngeal Cancer.
Yasuda K, Onimaru R, Okamoto S, Shiga T, Katoh N, Tsuchiya K, Suzuki R, Takeuchi W, Kuge Y, Tamaki N, Shirato H
Int J Radiat Oncol Biol Phys. 85(1) 142-7 2013
Pathophysiological Characteristics of Melanoma In-Transit Metastasis in a Lymphedema Mouse Model.
Oashi K, Furukawa H, Nishihara H, Ozaki M, Oyama A, Funayama E, Hayashi T, Kuge Y, Yamamoto Y
J Invest Dermatol. 133(2) 537-44 2013
Bone Marrow Stromal Cells Transplantation Enhances Recovery of Local Glucose Metabolism after Cerebral Infarct in Rats ? A Serial 18F-FDG PET Study.
Miyamoto M, Kuroda S, Zhao S, Magota K, Maruichi K, Ito M, Kawabori M, Shichinohe H, Houkin K, Kuge Y, Tamaki N
J Nucl Med 54(1) 145-50 2013
Biological characteristics of intratumoral [F-18]fluoromisonidazole distribution in a rodent model of glioma.
Hatano T, Zhao S, Zhao Y, Nishijima K, Kuno N, Hanzawa H, Sakamoto T, Tamaki N Kuge Y
Int J Oncol. 42(3) 823-30 2013
High Reproducibility of Tumor Hypoxia Evaluated by 18F-Fluoromisonidazole PET for Head and Neck Cancer.
Okamoto S, Shiga T, Yasuda K, Ito YM, Magota K, Kasai K, Kuge Y, Shirato H, Tamaki N
J Nucl Med. 54(2) 201-7 2013
Timing and cell dose determine therapeutic effects of bone marrow stromal cell transplantation in rat model of cerebral infarct.
Kawabori M, Kuroda S, Ito M, Shichinohe H, Houkin K, Kuge Y, Tamaki N
Neuropathology. 33(2) 140-8 2013
Synthesis and evaluation of 11C-labeled naphthalene derivative as a novel non-peptidergic probe for the β-secretase (BACE1) imaging in Alzheimer's disease brain.
Kawai T, Kawashima H, Kuge Y, Saji H:
Nucl Med Biol. 40(5) 705-9 2013
Attenuation of apotosis by telmisartan in atherosclerotic plaques of apoE-/- mice: evaluation using 99mTc-annexin A5.
Zhao Y, Zhao S, Kuge Y, Strauss WH, Blankenberg FG, Tamaki N
Mol Imaging. 12(5) 300-9 2013
Monitoring tumor proliferative response to radiotherapy using 18F-fluorothymidine in human head and neck cancer xenograft in comparison with Ki-67.
Fatema CN, Zhao S, Zhao Y, Murakami M, Yu W, Nishijima K, Tamaki N, Kitagawa Y, Kuge Y
Ann Nucl Med. 27(4) 355-62 2013
18F-Fluoromisonidazole PET Uptake Is Correlated with Hypoxia-Inducible Factor-1α Expression in Oral Squamous Cell Carcinoma.
Sato J, Kitagawa Y, Yamazaki Y, Hata H, Okamoto S, Shiga T, Shindoh M, Kuge Y, Tamaki N
J Nucl Med. 54(7) 1060-5 2013
Radiation-induced nitric oxide mitigates tumor hypoxia and radioresistance in a murine SCCVII tumor model.
Nagane M, Yasui H, Yamamori T, Zhao S, Kuge Y, Tamaki N, Kameya H, Nakamura H, Fujii H, Inanami O
Biochem Biophys Res Commun. 437(3) 420-425 2013
123I-Iomazenil Single Photon Emission Computed Tomography Visualizes Recovery of Neuronal Integrity by Bone Marrow Stromal Cell Therapy in Rat Infarct Brain.
Saito H, Magota K, Zhao S, Kubo N, Kuge Y, Shichinohe H, Houkin K, Tamaki N, Kuroda S
Stroke. 44(10) 2869-74 2013
Increased intratumoral fluorothymidine (FLT) uptake level after multikinase inhibitor sorafenib treatment in a human renal cell carcinoma xenograft.
Murakami M, Zhao S, Zhao Y, Fatema CN, Yu W, Nishijima K, Takiguchi M, Tamaki N, Kuge Y
Oncology Letters. 6(3) 667-672 2013
Identification of stable cytotoxic factors in the gas phase extract of cigarette smoke and pharmacological characterization of their cytotoxicity.
Noya Y, Seki K, Asano H, Mai Y, Horinouchi T, Higashi T, Terada K, Hatate C, Hoshi A, Nepal P, Horiguchi M, Kuge Y, Miwa S
Toxicology 314(1) 1-10 2013
Contribution of Toll-Like Receptor 2 to the Response against Staphylococcus aureus Infection in Mice.
Yi M, Kohanawa M, Zhao S, Ozaki M, Haga S, Nan G, Kuge Y, Tamaki N
Plos One 8(9) e74287 2013
Assessment of early changes in 3H-fluorothymidine uptake after treatment with gefitinib in human tumor xenograft in comparison with Ki-67 and phospho-EGFR expression.
Zhao S, Kuge Y, Zhao Y, Takeuchi S, Hirata K, Takei T, Shiga T, Akita H, Tamaki N
BMC Cancer 13(1) 525 2013
Elevated 18F-FDG levels in blood and organs following angiotensin II receptor blocker administration: Experiment in mice administered telmisartan.
Zhao Y, Zhao S, Kuge Y, Tamaki N
J Nucl Med. 54(8) 1384-8 2013
18F-FDG uptake reflects thrombus formation and tissue factor expression via nuclear factor-κB in rabbit atherosclerotic lesions.
Yamashita A, Zhao Y, Zhao S, Matsuura Y, Sugita H, Iwakiri T, Koshimoto C, Kawai K, Tamaki N, Kuge Y, Asada Y
Circ J. 77(10) 2626-35 2013
Effect of Glycosylation on Biodistribution of Radiolabeled Glucagon-like Peptide 1
Watanabe A, Nishijima K, Zhao S, Tanaka Y, Itoh T, Takemoto H, Tamaki N, Kuge Y
Ann Nucl Med. 26(2) 184-91 2012
A novel murine model for non-alcoholic steatohepatitis developed by combination of a high-fat diet and oxidized low-density lipoprotein.
Yi M, Furumaki H, Matsuoka S, Sakurai T, Kohanawa M, Zhao S, Kuge Y, Tamaki N, Chiba H
Lab Invest. 92(2) 265-81 2012
Therapeutic effects of intra-arterial delivery of bone marrow stromal cells in traumatic brain injury of rats - In vivo cell tracking study by near infrared fluorescence imaging.
Osanai T, Kuroda S, Sugiyama T, Kawabori M, Ito M, Shichinohe H, Kuge Y, Houkin K, Tamaki N, Iwasaki Y
Neurosurgery. 70(2) 435-44 2012
Writing errors in ALS related to loss of neuronal integrity in the anterior cingulate gyrus.
Yabe I, Tsuji-Akimoto S, Shiga T, Hamada S, Hirata K, Otsuki M, Kuge Y, Tamaki N, Sasaki H
J Neurol Sci. 315(12) 55-9 2012
Intracerebral, but not intravenous, transplantation of bone marrow stromal cells enhances functional recovery in rat cerebral infarct: An optical imaging study.
Kawabori M, Kuroda S, Sugiyama T, Ito M, Shichinohe H, Houkin K, Kuge Y, Tamaki N
Neuropathology. 32(3) 217-26 2012
18F-Fluoromisonidazole positron emission tomography may differentiate glioblastoma multiforme from less malignant gliomas.
Hirata K, Terasaka S, Shiga T, Hattori N, Magota K, Kobayashi H, Yamaguchi S, Houkin K, Tanaka S, Kuge Y, Tamaki N
Eur J Nucl Med Mol Imaging. 39(5) 760-70 2012
Cardiac β-adrenergic receptor density and myocardial systolic function in the remote noninfarcted region after prior myocardial infarction with left ventricular remodelling.
Ohte N, Narita H, Iida A, Fukuta H, Iizuka N, Hayano J, Kuge Y, Tamaki N, Kimura G
Eur J Nucl Med Mol Imaging. 39 1246-1253 2012
Norepinephrine Transporter Imaging in the Brain of a Rat Model of Depression Using Radioiodinated (2S, αS)-2-(α-(2-iodophenoxy)benzyl)morpholine.
Kanegawa N, Kiyono Y, Sugitaa T, Kuge Y, Fujibayasi Y, Saji H
Mol Imaging. 11(4) 280-5 2012
Evaluation of changes in the tumor microenvironment after sorafenib therapy by sequential histology and 18F-fluoromisonidazole hypoxia imaging in renal cell carcinoma.
Murakami M, Zhao S, Zhao Y, Chowdhury NF, Yu W, Nishijima K, Takiguchi M, Tamaki N, Kuge Y
Int J Oncol. 41(5) 1593-600 2012
Quantitative Determination of Apoptosis of Pancreatic β-Cells in a Murine Model of Type 1 Diabetes Mellitus.
Watanabe A, Nishijima KI, Zhao S, Zhao Y, Tanaka Y, Takemoto H, Strauss HW, Blankenberg FG, Tamaki N, Kuge Y
J Nucl Med. 53(10) 1585-91 2012
11C-Methionine positron emission tomography may monitor the activity of encephalitis - a case report.
Hirata K, Shiga T, Fujima N, Manabe O, Usui R, Kuge Y, Tamaki N
Acta Radiologica. 53(10) 1155-7 2012
Ferrous Ferric Chloride Downregulates the Inflammatory Response to Rhodococcus aurantiacus Infection in Mice.
Yi M, Tao H, Kohanawa M, Zhao S, Kuge Y, Tamaki N
Biol Pharm Bull. 34(12) 2214-2223 2012
A radiolabeled uracil derivative as a novel SPECT probe for thymidine phosphorylase: Suppressed accumulation into tumor cells by target gene knockdown.
Li H, Zhao S, Jin Y, Nishijima K, Akizawa H, Ohkura K, Tamaki N, Kuge Y
Nucl Med Comn. 32(12) 1211-1215 2011
A Pre-targeting Strategy for MR Imaging of Functional Molecules Using Dendritic Gd-Based Contrast Agents.
Sano K, Temma T, Azuma T, Nakai R, Narazaki M, Kuge Y, Saji H
Mol Imaging Biol. 13(6) 1196-1203 2011
PET Imaging of Hypoxia-Inducible Factor-1-Active Tumor Cells with Pretargeted Oxygen-Dependent Degradable Streptavidin and a Novel (18)F-Labeled Biotin Derivative.
Kudo T, Ueda M, Konishi H, Kawashima H, Kuge Y, Mukai T, Miyano A, Tanaka S, Kizaka-Kondoh S, Hiraoka M, Saji H
Mol Imaging Biol. 13(5) 1003-1010 2011
Dynamic (11)C-methionine PET analysis has an additional value for differentiating malignant tumors from granulomas: an experimental study using small animal PET.
Zhao S, Kuge Y, Yi M, Zhao Y, Hatano T, Magota K, Nishijima K, Kohanawa M, Tamaki N
Eur J Nucl Med Mol Imaging. 38(10) 1876-1886 2011
Localization of Deoxyglucose and Annexin A5 in Experimental Atheroma Correlates with Macrophage Infiltration but not Lipid Deposition in the Lesion.
Zhao Y, Zhao S, Kuge Y, Strauss WH, Blankenberg FG, Tamaki N
Mol Imaging Biol. 13(4) 712-720 2011
Near-infrared fluorescence labeling allows non-invasive tracking of bone marrow stromal cells transplanted into rat infarct brain.
Sugiyama T, Kuroda S, Osanai T, Shichinohe H, Kuge Y, Ito M, Kawabori M, Iwasaki Y
Neurosurgery. 68(4) 1036-1047 2011
18F-Fluorothymidine PET/CT as an early predictor of tumor response to treatment with cetuximab in human lung cancer xenografts.
Takeuchi S, Zhao S, Kuge Y, Zhao Y, Nishijima KI, Hatano T, Shimizu Y, Kinoshita I, Tamaki N, Dosaka-Akita H
Oncol Rep. 26 725-730 2011
Gene and protein analysis of brain derived neurotrophic factor expression in relation to neurological recovery induced by an enriched environment in a rat stroke model.
Hirata K, Kuge Y, Yokota C, Harada A, Kokame K, Inoue H, Kawashima H, Hanzawa H, Shono Y, Saji H, Minematsu K, Tamaki N
Neurosci Lett. 495(3) 210-215 2011
Semiquantitative analysis of C-11 methionine PET may distinguish brain tumor recurrence from radiation necrosis even in small lesions.
Okamoto S, Shiga T, Hattori N, Kubo N, Takei T, Katoh N, Sawamura Y, Nishijima K, Kuge Y, Tamaki N
Ann Nucl Med. 25(3) 213-20 2011
Performance characterization of the Inveon preclinical small-animal PET/SPECT/CT system for multimodality imaging.
Magota K, Kubo N, Kuge Y, Nishijima K, Zhao S, Tamaki N
Eur J Nucl Med Mol Imaging. 38(4) 742-52 2011
Gene expression associated with an enriched environment after transient focal ischemia.
Shono Y, Yokota C, Kuge Y, Kido S, Harada A, Kokame K, Inoue H, Hotta M, Hirata K, Saji H, Tamaki N, Minematsu K
Brain Res. 1376 60-65 2011
Regional partition coefficient of water in patients with cerebrovascular disease and its effect on rCBF assessment.
Hirata K, Hattori N, Katoh C, Shiga T, Kuroda S, Kubo N, Usui R, Kuge Y, Tamaki N
Nucl Med Commun. 32(1) 63-70 2011
NIR fluorescent ytterbium compound for in vivo fluorescence molecular imaging.
Aita K, Temma T, Kuge Y, Seki KI, Saji H.
Luminescence. 25 19-24 2010
Synthesis of a New NIR Fluorescent Nd Complex Labeling Agent.
Aita K, Temma T, Shimizu Y, Kuge Y, Seki KI, Saji H.
J Fluoresc. 20(1) 225-34 2010
Nicotinic acetylcholine receptors expressed in the ventralposterolateral thalamic nucleus play an important role in anti-allodynic effects.
Ueda M, Iida Y, Tominaga A, Yoneyama T, Ogawa M, Magata Y, Nishimura H, Kuge Y, Saji H.
Br J Pharmacol. 159 1201-1210 2010
Isolation and identification of new vasodilative substances in diesel exhaust particles.
Seki K, Noya Y, Mikami Y, Taneda S, Suzuki AK, Kuge Y, Ohkura K.
Environ Sci Pollut Res. 17(3) 717-23 2010
In vitro and in vivo evaluations of a radioiodinated thymidine phosphorylase inhibitor as a tumor diagnostic agent for angiogenic enzyme imaging.
Akizawa H, Zhao S, Takahashi M, Nishijima K, Kuge Y, Tamaki N, Seki K, Ohkura K..
Nucl Med Biol. 37(4) 427-432 2010
Rapid detection of hypoxia-inducible factor-1-active tumours: pretargeted imaging with a protein degrading in a mechanism similar to hypoxia-inducible factor-1alpha.
Ueda M, Kudo T, Kuge Y, Mukai T, Tanaka S, Konishi H, Miyano A, Ono M, Kizaka-Kondoh S, Hiraoka M, Saji H.
Eur J Nucl Med Mol Imaging. 37(8) 1566-1574 2010
Radioimmunodetection of membrane type-1 matrix metalloproteinase relevant to tumor malignancy with a pre-targeting method.
Sano K, Temma T, Kuge Y, Kudo T, Kamihashi J, Zhao S, Saji H.
Biol Pharm Bull. 33(9) 1589-1595 2010
Imaging with radiolabelled anti-membrane type 1 matrix metalloproteinase (MT1-MMP) antibody: potentials for characterizing atherosclerotic plaques.
Kuge Y, Takai N, Ogawa Y, Temma T, Zhao Y, Nishigori K, Ishino S, Kamihashi J, Kiyono Y, Shiomi M, Saji H.
Eur J Nucl Med Mol Imaging. 37(11) 2093-2104 2010
Tissue factor detection for selectively discriminating unstable plaques in an atherosclerotic rabbit model.
Temma T, Ogawa Y, Kuge Y, Ishino S, Takai N, Nishigori K, Shiomi M, Ono M, Saji H.
J Nucl Med. 51(12) 1979-1986 2010
Clinical Value and Limitations of [(11)C]-Methionine PET for Detection and Localization of Suspected Parathyroid Adenomas.
Herrmann K, Takei T, Kanegae K, Shiga T, Buck AK, Altomonte J, Schwaiger M, Schuster T, Nishijima K, Kuge Y, Tamaki N.
Mol Imaging Biol. 11(5) 356-363 2009
Myocardial {beta}-Adrenergic Receptor Density Assessed by 11C-CGP12177 PET Predicts Improvement of Cardiac Function After Carvedilol Treatment in Patients with Idiopathic Dilated Cardiomyopathy.
Naya M, Tsukamoto T, Morita K, Katoh C, Nishijima K, Komatsu H, Yamada S, Kuge Y, Tamaki N, Tsutsui H.
J Nucl Med 50(2) 220-225 2009
Imaging of HIF-1-Active Tumor HypoxiaUsing a Protein Effectively Delivered to andSpecifically Stabilized in HIF-1-Active Tumor Cells.
Kudo T, Ueda M, Kuge Y, Mukai T, Tanaka S, Masutani M, Kiyono Y, Kizaka-Kondoh S, Hiraoka M, Saji H.
J Nucl Med. 50(6) 942-949 2009
Development of a radiolabeled probe for detecting membrane type-1 matrix metalloproteinase on malignant tumors.
Temma T, Sano K, Kuge Y, Kamihashi J, Takai N, Ogawa Y, Saji H.
Biol Pharm Bul. 32(7) 1272-1277 2009
Synthesis and evaluation of a radioiodinated Lumiracoxib derivative for the imaging of cyclooxygenase-2 expression.
KugeY, Obokata N, Kimura H, Katada Y, Temma T, Sugimoto Y, Aita K, Seki K, Tamaki N, Saji H.
Nucl Med Biol. 36(8) 869-76 2009
Mutual modulation between interleukin-10 and interleukin-6 induced by Rhodococcus aurantiacus infection in mice.
Yi M, Kohanawa M, Ozaki M, Haga S, Fujikawa K, Zhao S, Kuge Y, Tamaki N.
Microbes Infect. 10(14-15) 2008
Prominent lectin-like oxidized LDL receptor-1 (LOX-1) expression in atherosclerotic lesions is associated with tissue factor expression and apoptosis in hypercholesterolemic rabbits
Kuge Y, Kume N, Ishino S, Takai N, Ogawa Y, Mukai T, Minami M, Shiomi M, Saji H
Biol Pharm Bul. 31(8) 1475-1482 2008
Evaluation of radioiodinated (2S,alphaS)-2-(alpha-(2-iodophenoxy)benzyl)morpholine as a radioligand for imaging of norepinephrine transporter in the heart.
Kiyono Y, Sugita T, Ueda M, Kawashima H, Kanegawa N, Kuge Y, Fujibayashi Y, Saji H
Nucl Med Biol. 35(2) 213-218 2008
Usefulness of 11C-Methionine for Differentiating Tumors from Granulomas in Experimental Rat Models: A Comparison with 18F-FDG and 18F-FLT.
Zhao S, Kuge Y, Kohanawa M, Takahashi T, Zhao Y, Yi M, Kanegae K, Seki KI, Tamaki N.
J Nucl Med. 49(1) 135-141 2008
Targeting of lectin-like oxidized LDL receptor-1 (LOX-1) with radio-labeled anti-LOX-1 antibody: A potential probe for molecular imaging of vulnerable plaque
Ishino S, Mukai T, Kuge Y, Kume N, Ogawa M, Abe J, Takai N, Shiomi M, Minami M, Kita T, Saji H
J Nucl Med 49(10) 1677-1685 2008
Prolonged High-Fat Feeding Enhances Aortic 18F-FDG and 99mTc-annexin A5 Uptake in ApoE-/- and Wild-Type C57BL/6J mice.
Yan Zhao, Yuji Kuge, Songji Zhao, H. William Strauss, Francis G. Blankenberg, Nagara Tamaki
J Nucl Med 49(10) 1707-1714 2008
Synthesis of a radioiodinated thymidine phosphorylase inhibitor and its preliminary evaluation as a potential SPECT tracer for angiogenic enzyme expression.
Masayuki Takahashi, Koh-ichi Seki, Ken-ichi Nishijima, Songji Zhao, Yuji Kuge, Nagara Tamaki, Kazue Ohkura
J Labelled Compounds and Radiopharmaceuticals. 51(11) 384-387 2008
Heterogeneous Reduction of Myocardial Oxidative Metabolism in Patients With Ischemic and Dilated Cardiomyopathy Using C-11 Acetate PET.
Wu YW, Naya M, Tsukamoto T, Komatsu H, Morita K, Yoshinaga K, Kuge Y, Tsutsui H, Tamaki N.
Circ J. 72(5) 786-792 2008
SYNTHESIS OF 11C-LABELED URACIL DERIVATIVE FOR A PET TRACER TARGETING THYMIDINE PHOSPHORYLASE.
Takahashi M, Seki K, Nishijima K, Kuge Y, Tamaki N, Ohkura K
Heterocycles 76(1) 237-241 2008
PET O-15 cerebral blood flow and metabolism after acute stroke in spontaneously hypertensive rats. 
Temma T, Kuge Y, Sano K, Kamihashi J, Obokata N, Kawashima H, Magata Y, Saji H
Brain Res. 1212 18-24 2008
A novel and efficient synthesis of [2-11C]5-fluorouracil for prognosis of cancer chemotherapy.
Seki K, Nishijima K, Kuge Y, Tamaki N, Wiebe LI, Ohkura K
J Pharm Pharmaceut Sci. 10(2) 212-216 2007
All-trans retinoic acid enhances murine dendritic cell migration to draining lymph nodes via the balance of matrix metalloproteinases and their inhibitors.
Stephanie Darmanin, Jian Chen, 2, Songji Zhao, Hongyan Cui, Reza Shirkoohi, Naoki Kubo, Yuji Kuge, Nagara Tamaki, Koji Nakagawa, Jun-ichi Hamada, Tetsuya Moriuchi, Masanobu Kobayashi
J Immunology 179(7) 4616-25 2007
Lectin-like oxidized LDL receptor-1 (LOX-1) expression is associated with atherosclerotic plaque instability-analysis in hypercholesterolemic rabbits.
Ishino S, Mukai T, Kume N, Asano D, Ogawa M, Kuge Y, Minami M, Kita T, Shiomi M, Saji H
Atherosclerosis. 195(1) 48-56 2007
Development of Novel Neodymium Compound for In Vivo Fluorescence Imaging. Luminescence (in press)
Aita K, Temma T, Kuge Y, Saji H
Luminescence 22(5) 455-61 2007
A high resolution small gamma camera based on semiconductor detector: applicability to small animal imaging.
Yasushi Kiyono, Yuji Kuge, Yumiko Katada, Yasuhiro Magata, Hideo Saji
Nucl Med Commun. 28(9) 736-741 2007
Comparison of 99mTc-annexin A5 with 18F-FDG for the detection of atherosclerosis in ApoE-/- mice.
Zhao Y, Kuge Y, Zhao S, Morita K, Inubushi M, Strauss HW, Blankenberg Fg, Tamaki N
Eur J Nucl Med Mol Imaging. 34(11) 1747-55 2007
Extensive 18F-FDG Uptake and Its Modification with Corticosteroid in a Granuloma Rat Model: An Experimental Study for Differentiating Granuloma from Tumors.
Zhao S, KugeY, Kohanawa M, Takahashi T, Kawashima H, Temma T, Takei T, Zhao Y, Seki K, Tamaki N
Eur J Nucl Med Mol Imaging 34(12) 2096-105 2007
99mTc-Annexin A5 for noninvasive characterization of atherosclerotic lesions: imaging and histological studies in myocardial infarction-prone Watanabe heritable hyperlipidemic rabbits.
Ishino S, Kuge Y*, Takai N, Tamaki N, Strauss HW, Blankenberg FG, Shiomi M, Saji H
Eur J Nucl Med Mol Imaging. 34(6) 889-899 2007
Decreased myocardial beta-adrenergic receptor density in relation to increased sympathetic tone in patients with nonischemic cardiomyopathy.
Tsukamoto T, Morita K, Naya M, Inubushi M, Katoh C, Nishijima K, Kuge Y, Okamoto H, Tsutsui H, Tamaki N.
J Nucl Med. 48(11) 1777-82 2007
Comparison of MET-PET and FDG-PET for differentiation between benign lesions and lung cancer in pneumoconiosis.
Kanegae K, Nakano I, Kimura K, Kaji H, Kuge Y, Shiga T, Zhao S, Okamoto S, Tamaki N
Ann Nucl Med. 21(6) 331-337 2007
Expression Profiles of MT1-MMP, MMP-2 and COX-2 in Rabbit Atherosclerosis: Comparison with Plaque Instability Analysis.
Kuge Y*, Takai N, Ishino S, Temma T, Shiomi M, Saji H
Biol Pharm Bull 30(9) 1634-40 2007
Is MIBG a Substrate of P-glycoprotein?
Kiyono Y, Yamashita T, Doi H, Kuge Y, Katsura T, Inui K, Saji H
Eur J Nucl Med Mol Imaging. 34(4) 448-52 2007
Estimation of oxygen metabolism in a rat model of permanent ischemia using positron emission tomography with injectable 15O-O2.
Temma T, Magata Y, Kuge Y, Shimonaka S, Sano K, Katada Y, Kawashima H, Mukai T, Watabe H, Iida H, Saji H
J Cereb Blood Flow Metab. 26 1577-1583 2006
Synthesis and evaluation of radioiodinated cyclooxygenase-2 inhibitors as potential SPECT tracers for cyclooxygenase-2 expression.
Kuge Y*, Katada Y, Shimonaka S, Temma T, Kimura H, Kiyono Y, Yokota C, Minematsu K, Seki K, Tamaki N, Ohkura K, Saji H.
Nucl Med Biol. 33(1) 21-27 2006
Change of central cholinergic receptors following lesions of nucleus basalis magnocellularis in rats: search for an imaging index suitable for the early detection of Alzheimer's disease. 
Ogawa M, Iida Y, Nakagawa M, Kuge Y, Kawashima H, Tominaga A, Ueda M, Magata Y, Saji H
Nucl Med Biol. 33(2) 249-254 2006
Synthesis and evaluation of radioiodinated (S,S)-2-(alpha-(2-iodophenoxy)benzyl) morpholine for imaging brain norepinephrine transporter.
Kanegawa N, Kiyono Y, Kimura H, Sugita T, Kajiyama S, Kawashima H, Ueda M, Kuge Y, Saji H
Eur J Nucl Med Mol Imaging. 33(6) 639-647 2006
Loss of neuronal integrity: a cause of hypometabolism in patients with traumatic brain injury without MRI abnormality in the chronic stage.
Shiga T, Ikoma K, Katoh C, Isoyama H, Matsuyama T, Kuge Y, Kageyama H, Kohno T, Terae S, Tamaki N
Eur J Nucl Med Mol Imaging. 33(7) 817-822 2006
A new convenient method for the synthesis of [2-11C]thymine utilizing [11C]phosgene.
Ohkura K, Nishijima K, Sanoki K, Kuge Y, Tamaki N, Seki K
Tetrahedron Letters. 47 5321-5323 2006
Photochemical synthesis of polycyclic pyrimidines through the acid catalyzed cycloaddition of 6-chloro-1-methyluracil to methyl substituted bezenes.
Ohkura K, Yamaguchi T, Nishijima K, Kuge Y, Seki K
Heterocycles. 70 501-508 2006
Myocardial flow reserve is influenced by both coronary artery stenosis severity and coronary risk factors in patients with suspected coronary artery disease.
Tsukamoto T, Morita K, Naya M, Katoh C, Inubushi M, Kuge Y, Tsutsui H, Tamaki N
Eur J Nucl Med Mol Imaging. 33 1150-1156 2006
Smoking Cessation Normalizes Coronary Endothelial Vasomotor Response Assessed with 15O-Water and PET in Healthy Young Smokers.
Morita K, Tsukamoto T, Naya M, Noriyasu K, Inubushi M, Shiga T, Katoh C, Kuge Y, Tsutsui H, Tamaki N
J Nucl Med. 47(12) 1914-1920 2006
Evaluating performance of a pixel array semiconductor SPECT system for small animal imaging.
Kubo N, Zhao S, Fujiki Y, Kinda A, Motomura N, Katoh C, Shiga T, Kawashima H, Kuge Y, Tamaki N
Ann Nucl Med. 19(7) 633-639 2005
Aggravation of hemorrhagic transformation by early intraarterial infusion of low-dose vascular endothelial growth factor after transient focal cerebral ischemia in rats.
Abumiya T, Yokota C, Kuge Y, Minematsu K
Brain Res. 1049(1) 95-103 2005
Bilateral induction of the S-100A9 gene in response to spreading depression is modulated by the cyclooxygenase-2 activity.
Yokota C, Kuge Y, Inoue H, Tamaki N, Minematsu K
J Neurol Sci. 234 11-16 2005
Quantitative analysis of myocardial glucose utilization in patients with left ventricular dysfunction by means of 18F-FDG dynamic positron tomography and three-compartment analysis.
Morita K, Katoh C, Yoshinaga K, Noriyasu K, Mabuchi M, Tsukamoto T, Kageyama H, Shiga T, Kuge Y, Tamaki N
Eur J Nucl Med Mol Imaging. 32(7) 806-812 2005
Enhanced apoptotic reaction correlates with suppressed tumor glucose utilization following cytotoxic chemotherapy: using 99mTc-annexin V, 18F-FDG and histological evaluation.
Takei T, Kuge Y, Zhao S, Sato M, Strauss HW, Blankenberg FG, Tait JF, Tamaki N
J Nucl Med. 46(5) 794-799 2005
Biological correlates of intratumoral heterogeneity in FDG distribution with regional expression of glucose transporters and hexokinase-II in experimental tumor.
Zhao S, Kuge Y, Mochizuki T, Takahashi T, Nakada K, Sato M, Takei T, Tamaki N
J Nucl Med. 46(4) 675-682 2005
Temporal and topographic profile of cyclooxygenase-2 expression during 24 hours of focal ischemia.
Yokota C, Kaji T, Kuge Y, Inoue H, Tamaki N, Minematsu K
Neurosci Lett. 357(3) 219-222 2004
Effect of steroids on [18F]Fluorodeoxyglucose uptake in experimental tumors.
Zhao S, Kuge Y, Nakada K, Mochiduki T, Takei T, Nishijima K, Okada F, Tamaki N
Nucl Med Commun. 25(7) 727-730 2004
Preparation and Pre-clinical Evaluation of High Specific Activity [11C]CGP-12177.
Nishijima K, Kuge Y, Seki K, Ohkura K, Morita K, Nakada K, Tamaki N
Nucl Med Commun. 25(8) 845-849 2004
Use of a standardized uptake value for parametric in vivo imaging of benzodiazepine receptor distribution on [11C]flumazenil brain PET.
Tsukamoto M, Katoh C, Shiga T, Kaji T, Kuge Y, Nakada K, Tamaki N
Eur J Nucl Med Mol Imaging. 31(6) 846-851 2004
Characterization of [123I]iomazenil distribution in a rat model of focal cerebral ischemia in comparison with pathophysiological findings.
Kaji T, Kuge Y, Yokota C, Tagaya M, Inoue H, Shiga T, Minematsu K, Tamaki N
Eur J Nucl Med Mol Imaging. 31(1) 64-70 2004
Feasibility of 99mTc-Annexin V for Repetitive Detection of Apoptotic Tumor Response to Chemotherapy: An Experimental Study Using a Rat Tumor Model.
Kuge Y, Sato M, Zhao S, Takei T, Nakada K, Seki KI, Strauss HW, Blankenberg FG, Tait JF, Tamaki N
J Nucl Med. 45(2) 309-312 2004
Reduced Oxidative Metabolic Response in Dysfunctional Myocardium with Preserved Glucose Metabolism but with Impaired Contractile Reserve.
Yoshinaga K, Katoh C, Beanlands RS, Noriyasu K, Komuro K, Yamada S, Kuge Y, Morita K, Kitabatake A, Tamaki N
J Nucl Med. 45(11) 1885-1891 2004
Time course of apoptotic tumor response following a single dose of chemotherapy: comparison with 99mTc-annexin V uptake and rates of positively immunostained cells in an experimental model.
Takei T, Kuge Y, Zhao S, Sato M, Strauss HW, Blankenberg FG, Tait JF, Tamaki N
J Nucl Med. 45(12) 2083-2087 2004
Serial Changes in BMIPP Uptake in Relation to Thallium in the Rat Myocardium after Ischemia.
Noriyasu K, Mabuchi M, Kuge Y, Morita K, Tsukamoto T, Kohya T, Kitabatake A, Tamaki N
Eur J Nucl Med Mol Imaging. 30(12) 1644-1650 2003
Post-ischemic cyclooxygenase-2 expression is regulated by the extent of cerebral blood flow reduction in non-human primates. 
Yokota C, Kuge Y, Inoue H, Tagaya M, Kito G, Susumu T, Tamaki N, Minematsu K
Neurosci Lett. 341(1) 37-40 2003
Facile synthesis of 4a-fluoro-5,10-ethenobenzo[f]-quinazolines through 1, 4-photocycloaddition of 5-fluoro-1,3-dimethyluracil with substituted naphthalenes.
Ohkura K, Sugaoi T, Ishihara T, Aizawa K, Nishijima K, Kuge Y, Seki K
Heterocycles. 61 377-389 2003
Dominant-Negative Hypoxia-Inducible Factor-1alpha Reduces Tumorigenicity of Pancreatic Cancer Cells through the Suppression of Glucose Metabolism. 
Chen J, Zhao S, Nakada K, Kuge Y, Tamaki N, Okada F, Wang J, Shindo M, Higashino F, Takeda K, Asaka M, Katoh H, Sugiyama T, Hosokawa M, Kobayashi M
Am J Pathol. 162(4) 1283-1291 2003
Reduction of coronary flow reserve in areas with and without ischemia on stress perfusion imaging in patients with coronary artery disease: A study using oxygen 15-labeled water PET.
Yoshinaga K, Katoh C, Noriyasu K, Iwado Y, Furuyama H, Ito Y, Kuge Y, Kohya T, Kitabatake A, Tamaki N
J Nucl Cardiol. 10(3) 275-283 2003
Altered myocardial flow reserve and endothelial function late after Kawasaki disease.
Furuyama H, Odagawa Y, Katoh C, Iwado Y, Ito Y, Noriyasu K, Mabuchi M, Yoshinaga K, Kuge Y, Kobayashi K, Tamaki N
J Pediatr. 142(2) 149-154 2003
Cyclooxygenase-2 Expression Associated With Spreading Depression in a Primate Model. 
Yokota C, Inoue H, Kuge Y, Abumiya T, Tagaya M, Hasegawa Y, Ejima N, Tamaki N, Minematsu K
J Cereb Blood Flow Metab. 23(4) 395-398 2003
Estimation of myocardial blood flow and myocardial flow reserve by (99m)Tc-sestamibi imaging: comparison with the results of [15O]H2O PET.
Ito Y, Katoh C, Noriyasu K, Kuge Y, Furuyama H, Morita K, Kohya T, Kitabatake A, Tamaki N
Eur J Nucl Med Mol Imaging. 30(2) 281-287 2003
Detection of Apoptotic Tumor Response In Vivo After a Single Dose of Chemotherapy with 99mTc-Annexin V.
Mochizuki T, Kuge Y, Zhao S, Tsukamoto E, Hosokawa M, Strauss HW, Blankenberg FG, Tait JF, Tamaki N
J Nucl Med. 44(1) 92-97 2003
Characteristic Brain Distribution of [1-14C]Octanoate in a Rat Model of Focal Cerebral Ischemia in Comparison with Those of [123I]IMP and [123I]Iomazenil.
Kuge Y*, Hikosaka K, Seki K, Ohkura K, Nishijima KC, Kaji T, Ueno S, Tsukamoto E, Tamaki N
J Nucl Med. 44(7) 1168-1175 2003
Assessment of coronary function in children with a history of Kawasaki disease using 15O-water positron emission tomography.
Furuyama H, Odagawa Y, Katoh C, Iwado Y, Yoshinaga K, Ito Y, Noriyasu K, Mabuchi M, Kuge Y, Kobayashi K, Tamaki N
Circulation 105 2878-2884 2002
Unique Profile of Spreading Depression in a Primate Model.
Yokota C, Kuge Y, Hasegawa Y, Tagaya M, Abumiya T, Ejima N, Tamaki N, Yamaguchi T, Minematsu K
J Cereb Blood Flow Metab. 22(7) 835-842 2002
Quantitative evaluation of the relative contribution ratio of cerebral tissue to near-infrared signals in the adult human head: a preliminary study.
Kohri S, Hoshi Y, Tamura M, Kato C, Kuge Y, Tamaki N
Physiol Meas. 23(2) 301-312 2002
Value and limitation of myocardial fluorodeoxyglucose single photon emission computed tomography using ultra-high energy collimators for assessing myocardial viability.
Mabuchi M, Kubo N, Morita K, Noriyasu K, Itoh Y, Katoh C, Kuge Y, Tamaki N
Nucl Med Commun. 23(9) 879-885 2002
Fluorodeoxyglucose uptake and glucose transporter expression in experimental inflammatory lesions and malignant tumours: effects of insulin and glucose loading.
Zhao S, Kuge Y, Tsukamoto E, Mochizuki T, Kato T, Hikosaka K, Nakada K, Hosokawa M, Kohanawa M, Tamaki N
Nucl Med Commun. 23 545-550 2002
Intense F-18 FDG Accumulation in the Stomach in a Patient with Menetrier's Disease.
Kato T, Komatsu Y, Tsukamoto E, Takei M, Takei T, Yamamoto F, Kuge Y, Asaka M, Tamaki N
Clin Nucl Med. 27(5) 376-377 2002
Chemical Impurities in [18F]FDG Preparations Produced by Solid-Phase 18F-Fluorination.
Kuge Y*, Nishijima K, Nagatsu K, Seki K, Ohkura K, Tanaka A, Sasaki M, Tsukamoto E, Tamaki N
Nucl Med Biol. 29(2) 275-279 2002
In Vitro Uptake of [1-14C]Octanoate in Brain Slices of Rats: Basic studies for Assessing [1-11C]Octanoate as a PET Tracer of Glial Functions.
Kuge Y*, Hikosaka K, Seki K, Ohkura K, Nishijima K, Tsukamoto E, Tamaki N
Nucl Med Biol, 29(3) 303-306 2002
A Simple and improved synthesis of [11C]phosgene with iron and iron (III) oxide.
Nishijima K, Kuge Y*, Seki K, Ohkura K, Motoki N, Nagatsu K, Tanaka A, Tsukamoto E, Tamaki N
Nucl Med Biol. 29(3) 345-350 2002
Clinical role of 18F-FDG PET for initial staging of patients with extrahepatic bile duct cancer.
Kato T, Tsukamoto E, Kuge Y, Katoh C, Nambu T, Nobuta A, Kondo S, Asaka M, Tamaki N
Eur J Nucl Med Mol Imaging. 29(8) 1047-1054 2002
Low-dose dobutamine stress gated SPET for identification of viable myocardium: comparison with stress-rest perfusion SPET and PET.
Yoshinaga K, Katoh C, Noriyasu K, Yamada S, Ito Y, Kuge Y, Kawai Y, Kohya T, Kitabatake A, Tamaki N
Eur J Nucl Med. 29 882-890 2002
Stereoselective synthesis of 4a-fluoro-5,10-ethenobenzo[f]quinazolines via photo-Diels-Alder reaction of 5-fluoro-1,3-dimethyluracil with naphthalenes.
Ohkura K, Sugaoi T, Nishijima K, Kuge Y, Seki K
Tetrahedron Letters. 43 3113-3115 2002
SYNTHESIS OF 9,11-DIAZAPENTACYCLO[6.4.0.01,3.02,5.04,8]DO-DECANE-2,4-DIONES.
Ohkura K, Nishijima K, Kuge Y, Seki K
Heterocycles. 56 235-244 2002
Increased [18F]FDG yields with recycled target [18O]water: factors affecting the [18F]FDG yields.
Nishijima K, Kuge Y*, Tsukamoto E, Seki K, Ohkura K, Magata Y, Tanaka A, Nagatsu K, Tamaki N
Appl Radiat Isot. 57(1) 43-49 2002
Thermodynamically controlled photocycloaddition of 5-fluoro-1,3- dimethyluracil to naphthalenes.
Ohkura K, Sugaoi T, Sakushima A, Nishijima K, Kuge Y, Seki K
Heterocycles. 58 595-600 2002
Accumulation of [11C]acetate in normal prostate and benign prostate hyperplasia: comparison with prostate cancer.
Kato T, Tsukamoto E, Kuge Y, Takei T, Shiga T, Shinohara N, Katoh C, Nakada K, Tamaki N
Eur J Nucl Med Mol Imaging. 29(11) 1492-1495 2002
Decreased endothelium-dependent coronary vasomotion in healthy young smokers.
Iwado Y, Yoshinaga K, Furuyama H, Ito Y, Noriyasu K, Katoh C, Kuge Y, Tsukamoto E, Tamaki N
Eur J Nucl Med Mol Imaging. 29(8) 984-990 2002
Experimental thromboembolic stroke in cynomolgus monkey.
Kito G, Nishimura A, Susumu T, Nagata R, Kuge Y, Yokota C, Minematsu K
J Neurosci Meth. 105 45-53 2001
Performance assessment of O-18 water purifier.
Kitano H, Magata Y, Tanaka A, Mukai T, Kuge Y, Nagatsu K, Konishi J, Saji H
Ann Nucl Med. 15 75-78 2001
Serial Changes in Cerebral Blood Flow and Flow-Metabolism Uncoupling in Primates with Acute Thromboembolic Stroke.
Kuge Y*, Yokota C, Tagaya M, Hasegawa Y, Nishimura A, Kito G, Tamaki N, Hashimoto N, Yamaguchi T, Minematsu K
J Cereb Blood Flow Metab. 21 202-210 2001
Effects of insulin and glucose loading on FDG uptake in experimental malignant tumors and inflammatory lesions.
Zhao S, Kuge Y, Tsukamoto E, Mochizuki T, Kato T, Hikosaka K, Hosokawa M, Kohanawa M, Tamaki N
Eur J Nucl Med, 28 730-735 2001
FDG Uptake and Glucose Transporter Subtype Expressions in Experimental Tumor and Inflammation Models.
Mochizuki T, Tsukamoto E, Kuge Y, Kanegae K, Zhao S, Hikosaka K, Hosokawa M, Kohanawa M, Tamaki N
J Nucl Med. 42(10) 1551-1555 2001
Comparison of 18F-FDG, 131l-Na, and 201Tl in diagnosis of recurrent or metastatic thyroid carcinoma.
Shiga T, Tsukamoto E, Nakada K, Morita K, Kato T, Mabuchi M, Yoshinaga K, Katoh C, Kuge Y, Tamaki N
J Nucl Med. 42 414-419 2001
Low-dose dobutamine electrocardiograph-gated myocardial SPECT for identifying viable myocardium: comparison with dobutamine stress echocardiography and PET.
Yoshinaga K, Morita K, Yamada S, Komuro K, Katoh C, Ito Y, Kuge Y, Kohya T, Kitabatake A, Tamaki N
J Nucl Med. 42 838-844 2001
Preliminary Evaluation of [1-11C]Octanoate as a PET Tracer for Studying Cerebral Ischemia: A PET Study in Rat and Canine Models of Focal Cerebral Ischemia.
Kuge Y*, Kawashima H, Hashimoto T, Imanishi M, Shiomi M, Minematsu K, Hasegawa Y, Yamaguchi T, Miyake Y, Hashimoto N
Ann Nucl Med. 14 69-74 2000
Effects of Single and Repetitive Spreading Depression on Cerebral Blood Flow and Glucose Metabolism in Cats: A PET Study.
Kuge Y*, Hasegawa Y, Yokota C, Minematsu K, Hashimoto N, Miyake Y, Yamaguchi T
J Neurol Sci. 176 114-123 2000
[1-11C]Octanoate as a PET Tracer for Studying Ischemic Stroke: Evaluation in a Canine Model of Thromboembolic Stroke with Positron Emission Tomography.
Kuge Y*, Kawashima H, Minematsu K, Hasegawa Y, Yamaguchi T, Miyake Y, Hashimoto T, Imanishi M, Shiomi M, Tamaki N, Hashimoto N
Biol Pharm Bull. 23 984-988 2000
Biodistribution of 3,4-Dihydro-5-[11C]methoxy-1(2H)- isoquinolinone, A Potential PET Tracer for Poly(ADP-ribose)symthetase.
Miyake Y, Kuge Y, Shimadzu H, Hashimoto N, Ishida Y, Shibakawa M, Nishimura T
Nucl Med Biol. 27 701-705 2000
Development of Step Specific PET Tracers for Studying Fatty Acid -Oxidation: Biodistribution of [1-11C]Octanoate Analogs in Rats and Cats.
Kawashima H, Kuge Y*, Yajima K, Miyake Y, Hashimoto N
Nucl Med Biol. 25 543-548 1998
Positron Emission Tomography for Quantitative Determination of Glucose Metabolism in Normal and Ischemic Brains in Rats: An Insoluble Problem by the Harderian Glands
Kuge Y*, Minematsu K, Hasegawa Y, Yamaguchi T, Mori H, Matsuura H, Hashimoto N, Miyake Y
J Cereb Blood Flow Metab. 17 116-120 1997
Synthesis of [1-11C]-2-Octanoic Acid, [1-11C]-2-Decynoic Acid and [1-11C]-3-(R,S)-Methyloctanoic Acid as Potential Markers for PET Studies of Fatty Acid Metabolism.
Kawashima H, Yajima K, Kuge Y, Hashimoto N, Miyake Y
J Labelled Compounds and Radiopharmaceuticals. 39 181-193 1997
Uptake of Radioactive Octanoate in Astrocytoma Cells: Basic Studies for Application of [1-11C]Octanoate as a PET Tracer.
Yamazaki S, Fukui K, Kawashima H, Kuge Y, Miyake Y, Kangawa K
Ann Nucl Med. 10 395-399 1996
[1-11C]Octanoate as a Potential PET Tracer for Studying Glial Functions: PET Evaluation in Rats and Cats.
Kuge Y*, Kawashima H, Yamazaki S, Hashimoto N, Miyake Y
Nucl Med Biol. 23 1009-1012 1996
Antitumor Effect of Arterial Administration of a Medium-Chain Triglyceride Solution of an Angiogenesis Inhibitor, TNP-470, in Rabbits Bearing VX-2 Carcinoma.
Yanai S, Okada H, Saito K, Kuge Y, Misaki M, Ogawa Y, Toguchi H
Pharm Res. 12 653-657 1995
Optimal formulation of an Angiogenesis Inhibitor, TNP-470, for Arterial Injection Determined by in vitro Drug Release and Stability, and in vivo Antitumor Activity.
Yanai S, Okada H, Saito H, Kuge Y, Ogawa Y, Toguchi H
Int J Pharmaceut. 123 237-245 1995
Nylon Monofilament for Intraluminal Middle Cerebral Artery Occlusion in Rats.
Kuge Y, Minematsu K, Yamaguchi T, Miyake Y
Stroke. 26 1655-1658 1995
Brain Uptake and Metabolism of [1-11C]Octanoate in Rats: Pharmacokinetic Basis for its Application as a Radiopharmaceutical for Studying Brain Fatty Acid Metabolism
Kuge Y*, Yajima K, Kawashima H, Yamazaki H, Hashimoto N, Miyake Y
Ann Nucl Med. 9 137-142 1995
Antitumor Activity of a Medium-Chain Triglyceride Solution of the Angiogenesis Inhibitor TNP-470 (AGM-1470) When Administered Via the Hepatic Artery to Rats Bearing Walker 256 Carcinosarcoma in the Liver.
Yanai S, Okada H, Misaki M, Saito K, Kuge Y, Ogawa Y, Toguchi H
J Pharmcol Exp Ther. 271 1267-1273 1994
Accumulation of Radioactivity in the Pancreas After Intravenous Administration of [13N]Ammonia.
Saji H, Kuge Y, Yamamoto K, Magata Y, Yonekura Y, Konishi J, Yokoyama A.
Nucl Med Biol. 19 531-537 1992
Investigation of Radiopharmaceuticals for Pancreatic Imaging: Accumulation of Amines in the Pancreas.
Saji H, Kuge Y, Magata Y, Fujibayashi Y, Yokoyama A
Chem Pharm Bull. 40 161-164 1992
Accumulation and Metabolism of [125I]HIPDM in the Rat Pancreas.
Saji H, Kuge Y, Tsutsumi D, Yamamoto K, Konishi J, Yokoyama A
Ann Nucl Med. 5 157-161 1991

Bibliography

Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy
Kuge Y, Shiga T, Tamaki N
Springer 2016
Semiconductor Detector-Based Scanners for Nuclear Medicine
Takeuchi W, Suzuki A, Ueno Y, Shiga T, Hirata K, Okamoto S, Zhao S, Kuge Y, Kubo N, Kobayashi K, Watanabe S, Kobashi K, Umegaki K, Tamaki N
Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy. (Kuge Y, Shiga T, Tamaki N, eds.), Springer 2016
Development of a Microreactor for Synthesis of 18F-Labeled Positron Emission Tomography Probe
Kuno N, Manri N, Abo N, Asano Y, Nishijima K, Tamaki N, Kuge Y
Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy. (Kuge Y, Shiga T, Tamaki N, eds.), Springer 2016
Preclinical Evaluation of a Thymidine Phosphorylase Imaging Probe, [123I]IIMU, for Translational Research
Nishijima K, Zhao S, Feng F, Shimizu Y, Akizawa H, Ohkura K, Tamaki N, Kuge Y
Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy. (Kuge Y, Shiga T, Tamaki N, eds.), Springer 2016
Discovery and Evaluation of Biomarkers for Atherosclerosis
Sakamoto T, Hanzawa H, Manri N, Sakakibara M, Shimizu Y, Zhao Y, Zhao S, Yamada S, Kamiya K, Eki Y, Suzuki A, Higuchi H, Sugano C, Tsutsui H, Tamaki N, Kuge Y
Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy. (Kuge Y, Shiga T, Tamaki N, eds.), Springer 2016
Radioimmunodetection of Atherosclerotic Lesions Focusing on the Accumulation Mechanism of Immunoglobulin G
Shimizu Y, Hanzawa H, Zhao Y, Nishijima K, Fukura S, Sakamoto T, Zhao S, Tamaki N, Kuge Y
Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy. (Kuge Y, Shiga T, Tamaki N, eds.), Springer 2016
Molecular imaging for integrated medical therapy and drug development
Tamaki N, Kuge Y
Springer 2010
Advances in Molecular Imaging
Tamaki N, Kuge Y
Molecular imaging for integrated medical therapy and drug development. (Tamaki N, Kuge Y, eds), Springer 2010
Molecular Imaging for the Assessment of Tumor Malignancy and Response to Therapy
Kuge Y, Zhao S, Takei T, Tamaki N
Molecular imaging for integrated medical therapy and drug development. (Tamaki N, Kuge Y, eds), Springer 2010
Initial Performance Measurement of an Integrated PET/SPECT/CT System for Small Animal Imaging
Magota K, Kubo N, Narihiro K, Suzuki K, Nishijima K, Zhao S, Kuge Y, TamakiN
Molecular imaging for integrated medical therapy and drug development. (Tamaki N, Kuge Y, eds), Springer 2010
Display all
Bibliographyclose
Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy
Kuge Y, Shiga T, Tamaki N
Springer 2016
Semiconductor Detector-Based Scanners for Nuclear Medicine
Takeuchi W, Suzuki A, Ueno Y, Shiga T, Hirata K, Okamoto S, Zhao S, Kuge Y, Kubo N, Kobayashi K, Watanabe S, Kobashi K, Umegaki K, Tamaki N
Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy. (Kuge Y, Shiga T, Tamaki N, eds.), Springer 2016
Development of a Microreactor for Synthesis of 18F-Labeled Positron Emission Tomography Probe
Kuno N, Manri N, Abo N, Asano Y, Nishijima K, Tamaki N, Kuge Y
Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy. (Kuge Y, Shiga T, Tamaki N, eds.), Springer 2016
Preclinical Evaluation of a Thymidine Phosphorylase Imaging Probe, [123I]IIMU, for Translational Research
Nishijima K, Zhao S, Feng F, Shimizu Y, Akizawa H, Ohkura K, Tamaki N, Kuge Y
Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy. (Kuge Y, Shiga T, Tamaki N, eds.), Springer 2016
Discovery and Evaluation of Biomarkers for Atherosclerosis
Sakamoto T, Hanzawa H, Manri N, Sakakibara M, Shimizu Y, Zhao Y, Zhao S, Yamada S, Kamiya K, Eki Y, Suzuki A, Higuchi H, Sugano C, Tsutsui H, Tamaki N, Kuge Y
Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy. (Kuge Y, Shiga T, Tamaki N, eds.), Springer 2016
Radioimmunodetection of Atherosclerotic Lesions Focusing on the Accumulation Mechanism of Immunoglobulin G
Shimizu Y, Hanzawa H, Zhao Y, Nishijima K, Fukura S, Sakamoto T, Zhao S, Tamaki N, Kuge Y
Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy. (Kuge Y, Shiga T, Tamaki N, eds.), Springer 2016
Molecular imaging for integrated medical therapy and drug development
Tamaki N, Kuge Y
Springer 2010
Advances in Molecular Imaging
Tamaki N, Kuge Y
Molecular imaging for integrated medical therapy and drug development. (Tamaki N, Kuge Y, eds), Springer 2010
Molecular Imaging for the Assessment of Tumor Malignancy and Response to Therapy
Kuge Y, Zhao S, Takei T, Tamaki N
Molecular imaging for integrated medical therapy and drug development. (Tamaki N, Kuge Y, eds), Springer 2010
Initial Performance Measurement of an Integrated PET/SPECT/CT System for Small Animal Imaging
Magota K, Kubo N, Narihiro K, Suzuki K, Nishijima K, Zhao S, Kuge Y, TamakiN
Molecular imaging for integrated medical therapy and drug development. (Tamaki N, Kuge Y, eds), Springer 2010
Molecular Imaging of Atherosclerotic Plaque Vulnerability: Comparison between 18F-FDG and 99mTc-Annexin A5
Zhao Y, Kuge Y, Zhao S, Strauss HW, Blankenberg FG, Tamaki N
Molecular imaging for integrated medical therapy and drug development. (Tamaki N, Kuge Y, eds), Springer 2010
Bone Marrow Stromal Cell Transplantation for Central Nervous System Disorders ?Perspective for Translational Research and Clinical Application
Kuroda S, Kuge Y, Tamaki N, Iwasaki Y
Molecular imaging for integrated medical therapy and drug development. (Tamaki N, Kuge Y, eds), Springer 2010
Non-invasive Optical Tracking of Bone Marrow Stromal Cells Transplanted into Rat Cerebral Infarct
Sugiyama T, Kuroda S, Osanai T, Maruichi K, Chiba Y, Shichinohe H, Kuge Y, Tamaki N, Iwasaki Y
Molecular imaging for integrated medical therapy and drug development. (Tamaki N, Kuge Y, eds), Springer 2010
IAEA RADIOISOTOPES AND RADIOPHARMACEUTICALS SERIES No. 1. Technetium-99m Radiopharmaceuticals: Status and Trends. Chapter 11 Technetium-99m Annexin-A5 for Apoptosis Imaging
Kuge Y
INTERNATIONAL ATOMIC ENERGY AGENCY 2009
Positron Emission Tomography and Molecular Imaging: State of the Art and Future Perspectives
Tamaki N, Kuge Y
International Congress Series 1264, Elsevier Science B.V 2004
Clinical Nuclear Cardiology --State of the Art and Future Directions-- (3rd Edition) Section VIII Tracer Specific Imaging Technique, Chapter 35 Fatty Acid Imaging
Tamaki N, Morita K, Kuge Y
Elsevier 2004
Analysis of Neuronal and Glial Functions in Cerebral Ischemia: An Approach with Nuclear Medicine.
Kuge Y, Kaji T, Hikosaka K, Yokota C, Seki K, Ohkura K, Shiga T, Minematsu K, Tamaki N
Positron Emission Tomography and Molecular Imaging: State of the Art and Future Perspectives, International Congress Series 1264 (Y. Kuge, N. Tamaki, eds), Elsevier Science B.V 2004
The loss of neuronal integrity may be one of the causes of cognitive disturbances in the patients with brain traumatic injury and normal FLAIR and T2-weighted MRI.
Shiga T, Ikoma K, Tsukamoto M, Katoh C, Matsuyama T, Kuge Y, Nakada K, Tamaki N
Positron Emission Tomography and Molecular Imaging: State of the Art and Future Perspectives, International Congress Series 1264 (Y. Kuge, N. Tamaki, eds), Elsevier Science B.V 2004
Neuronal cyclooxygenase-2 induction associated with spreading depression and focal brain ischemia in primates.
Yokota C, Kuge Y, Hasegawa Y, Inoue H, Tagaya M, Abumiya T, Kito G, Tamaki N, Minematsu K
Positron Emission Tomography and Molecular Imaging: State of the Art and Future Perspectives, International Congress Series 1264 (Y. Kuge, N. Tamaki, eds), Elsevier Science B.V 2004
Methionine PET in differentiating recurrent brain tumor from radiation necrosis following cranial radiation.
Katoh N, Nakada K, Takei N, Aoyama H, Shirato H, Kato C, Kuge Y, Tsukamoto E, Tamaki N
Positron Emission Tomography and Molecular Imaging: State of the Art and Future Perspectives, International Congress Series 1264 (Y. Kuge, N. Tamaki, eds), Elsevier Science B.V 2004
Time course of apoptotic tumor response following a single dose of chemotherapy: Detection with 99mTc-annexin V and comparison with blood flow, caspase-3 expression and TUNEL staining in an experimental tumor model.
Takei T, Kuge Y, Zhao S, Mochizuki T, Strauss HW, Blankenberg F, Tait JF, Tamaki N
Positron Emission Tomography and Molecular Imaging: State of the Art and Future Perspectives, International Congress Series 1264 (Y. Kuge, N. Tamaki, eds), Elsevier Science B.V 2004
The impact of coronary stenosis and risk factors on myocardial flow reserve.
Tsukamoto T, Morita K, Noriyasu K, Katoh C, Kageyama H, Mabuchi K, Kuge Y, Nakada K, Okamoto H, Kitabatake A, Tamaki N
Positron Emission Tomography and Molecular Imaging: State of the Art and Future Perspectives, International Congress Series 1264 (Y. Kuge, N. Tamaki, eds), Elsevier Science B.V 2004
In vitro and in vivo characterization of high specific activity S-(-) [11C]CGP-12177, a radioligand for β-adrenoceptors, in rats.
Nishijima K, Kuge Y, Motoki N, Seki K, Ohkura K, Morita K, Tamaki N
Positron Emission Tomography and Molecular Imaging: State of the Art and Future Perspectives, International Congress Series 1264 (Y. Kuge, N. Tamaki, eds), Elsevier Science B.V 2004
Reduction of myocardial oxidative metabolism in dilated cardiomyopathy but not in remote areas in myocardial infarction.
Noriyasu K, Tsukamoto T, Morita K, Kageyama H, Mabuchi M, Katoh C, Kuge Y, Kitabatake A, Tamaki N
Positron Emission Tomography and Molecular Imaging: State of the Art and Future Perspectives, International Congress Series 1264 (Y. Kuge, N. Tamaki, eds), Elsevier Science B.V 2004
An ultra-high-energy collimator for small animal imaging in dual-isotope study of 18F and 99mTc.
Kubo N, Zhao S, Kinda A, Motomura N, Katoh C, Kuge Y, Tamaki N
Positron Emission Tomography and Molecular Imaging: State of the Art and Future Perspectives, International Congress Series 1264 (Y. Kuge, N. Tamaki, eds), Elsevier Science B.V 2004
Brain ischemia and spreading depression in a primate model.
Yokota C, Kuge Y, Tagaya M, Hasegawa Y, Abumiya T, Kito G, Yamaguchi T, Minematsu K
Strategic medical science against brain attack (Kikuchi H, ed.), Springer-Verlag 2002
Positron Emission Tomography in the Millennium
Tamaki N, Tsukamoto E, Kuge Y, Katoh C, Morita K
International Congress Series 1197, Elsevier Science B.V 2000
Clinical Utility of Combination of FDG-PET and CBF-SPECT in Extratemporal Lobe Epilepsy
Takano A, Shiga T, Kobayashi J, Nakamura F, Adachi I, Katoh C, Kuge Y, Koyama T, Tsukamoto E, Tamaki N
Positron Emission Tomography in the Millennium”, International Congress Series 1197 (Tamaki N, Tsukamoto E, Kuge Y, Katoh C, Morita K, eds.), Elsevier Science B.V. 2000
Quantitative Analysis for Myocardial Glucose Utilization Using Positron Emission Tomography and F-18-Deoxyglucose
Morita K, Katoh C, Yoshinaga K, Adachi I, Shiga T, Mabuchi M, Itoh Y, Konno M, Kohya T, Kitabatake A, Kuge Y, Tsukamoto E, Tamaki N
Positron Emission Tomography in the Millennium”, International Congress Series 1197 (Tamaki N, Tsukamoto E, Kuge Y, Katoh C, Morita K, eds.), Elsevier Science B.V. 2000
Clinical Usefulness of FDC-PET in the Patients with Differentiated Thyroid Cancer after Total Thyroidectomy
Shiga T, Tsukamoto E, Kato T, Morita K, Adachi I, Mabuchi M, Yoshinaga K, Suginami Y, Takano A, Tamaki N, Katoh C, Kuge Y
Positron Emission Tomography in the Millennium”, International Congress Series 1197 (Tamaki N, Tsukamoto E, Kuge Y, Katoh C, Morita K, eds.), Elsevier Science B.V. 2000
Visualization of Normal Organs in Whole-Body PET Imaging with F-18 FDG
Kato T, Tsukamoto E, Suginami Y, Mabuchi M, Yoshinaga K, Takano A, Adachi I, Shiga T, Morita K, Katoh C, Kuge Y, Tamaki N
Positron Emission Tomography in the Millennium”, International Congress Series 1197 (Tamaki N, Tsukamoto E, Kuge Y, Katoh C, Morita K, eds.), Elsevier Science B.V. 2000
Modified Method for Quantifying Regional Myocardial Blood Flow Using 15O-water with PET
Katoh C, Kuge Y, Morita K, Tsukamoto E, Tamaki N, Knuuti J
Positron Emission Tomography in the Millennium”, International Congress Series 1197 (Tamaki N, Tsukamoto E, Kuge Y, Katoh C, Morita K, eds.), Elsevier Science B.V. 2000
Animal PET Study in Development of Novel PET Tracers.
Kuge Y, Kawashima H, Ejima N, Miyake Y, Hashimoto N, Hashimoto T, Imanishi M, Shiomi M, Minematsu K, Hasegawa Y, Yamaguchi T, Tamaki N
Positron Emission Tomography in the Millennium”, International Congress Series 1197 (Tamaki N, Tsukamoto E, Kuge Y, Katoh C, Morita K, eds.), Elsevier Science B.V. 2000

Prizes

2002
The 40th award of the Japanese Society of Nuclear Medicine
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2002
The 40th award of the Japanese Society of Nuclear Medicine

Research Projects (Competitive Research Funds)

Molecular imaging for dynamic analysis of cancer pathological states : Toward clinical molecular imaging
Ministry of Education, Culture, Sports, Science and Technology : Grants-in-Aid for Scientific Research(基盤研究(B))
Date (from‐to) : 2008-2010 Author : Yuji KUGE
Molecular imaging and strategies for cancer treatment: A Study to achieve noninvasive in vivo pathological evaluation by molecular imaging
Ministry of Education, Culture, Sports, Science and Technology : Grants-in-Aid for Scientific Research(基盤研究(B))
Date (from‐to) : 2005-2007 Author : Yuji KUGE
Molecular imaging and patho-functional analysis of cerebral ischemia : focused on prostaglandin synthases
Ministry of Education, Culture, Sports, Science and Technology : Grants-in-Aid for Scientific Research(基盤研究(B))
Date (from‐to) : 2002-2004 Author : Yuji KUGE
Display all
Research Projects (Competitive Research Funds)close
Molecular imaging for dynamic analysis of cancer pathological states : Toward clinical molecular imaging
Ministry of Education, Culture, Sports, Science and Technology : Grants-in-Aid for Scientific Research(基盤研究(B))
Date (from‐to) : 2008-2010 Author : Yuji KUGE
Molecular imaging and strategies for cancer treatment: A Study to achieve noninvasive in vivo pathological evaluation by molecular imaging
Ministry of Education, Culture, Sports, Science and Technology : Grants-in-Aid for Scientific Research(基盤研究(B))
Date (from‐to) : 2005-2007 Author : Yuji KUGE
Molecular imaging and patho-functional analysis of cerebral ischemia : focused on prostaglandin synthases
Ministry of Education, Culture, Sports, Science and Technology : Grants-in-Aid for Scientific Research(基盤研究(B))
Date (from‐to) : 2002-2004 Author : Yuji KUGE

Educational Activities

Classes

Health and Society
Year : 2015
Introduction to Medical Research
Year : 2015
Principles of Medicine
Year : 2015
Principles of Medicine
Year : 2015
Master's Thesis Research in Medical Sciences Ⅰ
Year : 2015
Master's Thesis Research in Medical Sciences Ⅰ
Year : 2015
Master's Thesis Research in Medical Sciences Ⅱ
Year : 2015
Master's Thesis Research in Medical Sciences Ⅱ
Year : 2015
Introduction to Basic Medical Research
Year : 2015
Basic Principles of Medicine
Year : 2015
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Health and Society
Year : 2015
Introduction to Medical Research
Year : 2015
Principles of Medicine
Year : 2015
Principles of Medicine
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Master's Thesis Research in Medical Sciences Ⅰ
Year : 2015
Master's Thesis Research in Medical Sciences Ⅰ
Year : 2015
Master's Thesis Research in Medical Sciences Ⅱ
Year : 2015
Master's Thesis Research in Medical Sciences Ⅱ
Year : 2015
Introduction to Basic Medical Research
Year : 2015
Basic Principles of Medicine
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Dissertation Research in Medical Sciences Ⅰ
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Dissertation Research in Medical Sciences Ⅰ
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Dissertation Research in Medical Sciences Ⅱ
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Dissertation Research in Medical Sciences Ⅱ
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Master's Thesis Research in Basic Medicine Ⅰ
Year : 2015
Master's Thesis Research in Basic Medicine Ⅰ
Year : 2015
Master's Thesis Research in Basic Medicine Ⅱ
Year : 2015
Master's Thesis Research in Basic Medicine Ⅱ
Year : 2015
Molecular and Cellular Biology of Living Body
Year : 2015
Dissertation Research in Clinical Medicine Ⅰ
Year : 2015
Dissertation Research in Clinical Medicine Ⅱ
Year : 2015
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Health and Society
Year : 2014
Introduction to Medical Research
Year : 2014
Principles of Medicine
Year : 2014
Principles of Medicine
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Master's Thesis Research in Medical Sciences Ⅰ
Year : 2014
Master's Thesis Research in Medical Sciences Ⅰ
Year : 2014
Master's Thesis Research in Medical Sciences Ⅱ
Year : 2014
Master's Thesis Research in Medical Sciences Ⅱ
Year : 2014
Introduction to Basic Medical Research
Year : 2014
Basic Principles of Medicine
Year : 2014
Dissertation Research in Medical Sciences Ⅰ
Year : 2014
Dissertation Research in Medical Sciences Ⅰ
Year : 2014
Dissertation Research in Medical Sciences Ⅱ
Year : 2014
Dissertation Research in Medical Sciences Ⅱ
Year : 2014
Master's Thesis Research in Basic Medicine Ⅰ
Year : 2014
Master's Thesis Research in Basic Medicine Ⅰ
Year : 2014
Master's Thesis Research in Basic Medicine Ⅱ
Year : 2014
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Year : 2014
Dissertation Research in Clinical Medicine Ⅰ
Year : 2014
Dissertation Research in Clinical Medicine Ⅱ
Year : 2014
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Health and Society
Year : 2013
Molecular Imaging: For Drug Discovery and Advanced Medical Care
Year : 2013
Introduction to Medical Research
Year : 2013
Principles of Medicine
Year : 2013
Principles of Medicine
Year : 2013
Master's Thesis Research in Medical Sciences Ⅰ
Year : 2013
Master's Thesis Research in Medical Sciences Ⅰ
Year : 2013
Master's Thesis Research in Medical Sciences Ⅱ
Year : 2013
Master's Thesis Research in Medical Sciences Ⅱ
Year : 2013
Introduction to Basic Medical Research
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Basic Principles of Medicine
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Dissertation Research in Medical Sciences Ⅰ
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Dissertation Research in Medical Sciences Ⅰ
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Master's Thesis Research in Basic Medicine Ⅰ
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Disertation Research in Clinical Medicine Ⅰ
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Year : 2013

Contribution to Society

Committee Career

2013
-
Today
Japanese Society for Molecular Imaging Director
2013
-
Today
The Japanese Society of Cerebral Blood Flow & Metabolism Manager
2011
-
Today
Universities and other radiation facility Council Director
2010
-
Today
Japanese Society of Radiation Safety Management Director
2001
-
Today
The Japanese Society of Nuclear Medicine Councilor
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2013
-
Today
Japanese Society for Molecular Imaging Director
2013
-
Today
The Japanese Society of Cerebral Blood Flow & Metabolism Manager
2011
-
Today
Universities and other radiation facility Council Director
2010
-
Today
Japanese Society of Radiation Safety Management Director
2001
-
Today
The Japanese Society of Nuclear Medicine Councilor

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