小笠原 泰志オガサワラ ヤスシresearchmap個人ページ

更新日 : 2018/09/14

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プロフィール

所属部署名
工学研究院 応用化学部門 生物工学分野
職名助教 
学位
博士(理学)(東京工業大学)
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ホームページURL
科研費研究者番号

研究活動

論文

Unique N-phenylacetylation and NRPS with Substrate Promiscuity for Biosynthesis of Heptapeptide Variants, JBIR-78 and JBIR-95.
Takeda K, Kemmoku K, Satoh Y, Ogasawara Y, Shin-Ya K, Dairi T, ACS chemical biology
 2017年05月
Biosynthesis of Oligopeptides using ATP-grasp Enzymes.
Ogasawara Y, Dairi T, Chemistry, Weinheim an der Bergstrasse, Germany)
 2017年05月
Identification of tirandamycins as specific inhibitors of the futalosine pathway.
Ogasawara Y, Kondo K, Ikeda A, Harada R, Dairi T, The Journal of antibiotics
 2017年03月
A Glycopeptidyl-Glutamate Epimerase for Bacterial Peptidoglycan Biosynthesis.
Feng R, Satoh Y, Ogasawara Y, Yoshimura T, Dairi T, Journal of the American Chemical Society, vol. 139, no. 12, pp. 4243-4245
 139(12) 4243-4245 2017年03月
Identification and Characterization of Enzymes Catalyzing Pyrazolopyrimidine Formation in the Biosynthesis of Formycin A.
Ko Y, Wang SA, Ogasawara Y, Ruszczycky MW, Liu HW, Organic letters, vol. 19, no. 6, pp. 1426-1429
 19(6) 1426-1429 2017年03月
Biosynthesis of the Carbonylmethylene Structure Found in the Ketomemicin Class of Pseudotripeptides.
Kawata J, Naoe T, Ogasawara Y, Dairi T, Angewandte Chemie, International ed. in English)
 2017年01月
Characterization of three amidinotransferases involved in the biosynthesis of ketomemicins
Ogasawara Y, Fujimori M, Kawata J, Dairi T.
Bioorganic and Medicinal Chemistry Letters 26(15) 3662-3664 2016年
Exploring Peptide Ligase Orthologs in Actinobacteria - Discovery of Pseudopeptide Natural Products, Ketomemicins
Ogasawara Y, Kawata J, Noike M, Satoh Y, Furihata K, Dairi T.
ACS Chemical Biology 11(6) 1686-1692 2016年
Structure and activity relationships of the anti-Mycobacterium antibiotics resorcinomycin and pheganomycin
Ogasawara Y, Ooya K, Fujimori M, Noike M, Dairi T.
Journal of Antibiotics 69(2) 119-120 2016年
High-Quality Draft Genome Sequence of Actinobacterium Kibdelosporangium sp. MJ126-NF4, Producer of Type II Polyketide Azicemicins, Using Illumina and PacBio Technologies.
Ogasawara Y, Torrez-Martinez N, Aragon AD, Yackley BJ, Weber JA, Sundararajan A, Ramaraj T, Edwards JS, Melançon CE 3rd
Genome announcements 3(2) 2015年04月
論文を全て表示する
論文閉じる
Unique N-phenylacetylation and NRPS with Substrate Promiscuity for Biosynthesis of Heptapeptide Variants, JBIR-78 and JBIR-95.
Takeda K, Kemmoku K, Satoh Y, Ogasawara Y, Shin-Ya K, Dairi T, ACS chemical biology
 2017年05月
Biosynthesis of Oligopeptides using ATP-grasp Enzymes.
Ogasawara Y, Dairi T, Chemistry, Weinheim an der Bergstrasse, Germany)
 2017年05月
Identification of tirandamycins as specific inhibitors of the futalosine pathway.
Ogasawara Y, Kondo K, Ikeda A, Harada R, Dairi T, The Journal of antibiotics
 2017年03月
A Glycopeptidyl-Glutamate Epimerase for Bacterial Peptidoglycan Biosynthesis.
Feng R, Satoh Y, Ogasawara Y, Yoshimura T, Dairi T, Journal of the American Chemical Society, vol. 139, no. 12, pp. 4243-4245
 139(12) 4243-4245 2017年03月
Identification and Characterization of Enzymes Catalyzing Pyrazolopyrimidine Formation in the Biosynthesis of Formycin A.
Ko Y, Wang SA, Ogasawara Y, Ruszczycky MW, Liu HW, Organic letters, vol. 19, no. 6, pp. 1426-1429
 19(6) 1426-1429 2017年03月
Biosynthesis of the Carbonylmethylene Structure Found in the Ketomemicin Class of Pseudotripeptides.
Kawata J, Naoe T, Ogasawara Y, Dairi T, Angewandte Chemie, International ed. in English)
 2017年01月
Characterization of three amidinotransferases involved in the biosynthesis of ketomemicins
Ogasawara Y, Fujimori M, Kawata J, Dairi T.
Bioorganic and Medicinal Chemistry Letters 26(15) 3662-3664 2016年
Exploring Peptide Ligase Orthologs in Actinobacteria - Discovery of Pseudopeptide Natural Products, Ketomemicins
Ogasawara Y, Kawata J, Noike M, Satoh Y, Furihata K, Dairi T.
ACS Chemical Biology 11(6) 1686-1692 2016年
Structure and activity relationships of the anti-Mycobacterium antibiotics resorcinomycin and pheganomycin
Ogasawara Y, Ooya K, Fujimori M, Noike M, Dairi T.
Journal of Antibiotics 69(2) 119-120 2016年
High-Quality Draft Genome Sequence of Actinobacterium Kibdelosporangium sp. MJ126-NF4, Producer of Type II Polyketide Azicemicins, Using Illumina and PacBio Technologies.
Ogasawara Y, Torrez-Martinez N, Aragon AD, Yackley BJ, Weber JA, Sundararajan A, Ramaraj T, Edwards JS, Melançon CE 3rd
Genome announcements 3(2) 2015年04月
High-Quality Draft Genome Sequence of Actinobacterium Kibdelosporangium sp. MJ126-NF4, Producer of Type II Polyketide Azicemicins, Using Illumina and PacBio Technologies.
Ogasawara Y, Torrez-Martinez N, Aragon AD, Yackley BJ, Weber JA, Sundararajan A, Ramaraj T, Edwards JS, Melançon CE, Genome announcements, vol. 3, no. 2
 3(2) 2015年04月
Identification and analysis of the resorcinomycin biosynthetic gene cluster
Ooya K, Ogasawara Y, Noike M, Dairi T.
Bioscience, Biotechnology and Biochemistry 79(11) 1833-1837 2015年
Expanding our Understanding of Sequence-Function Relationships of Type II Polyketide Biosynthetic Gene Clusters: Bioinformatics-Guided Identification of Frankiamicin A from Frankia sp. EAN1pec.
Ogasawara Y, Yackley BJ, Greenberg JA, Rogelj S, Melançon CE 3rd
PloS one 10(4) e0121505 2015年
GenK-catalyzed C-6' methylation in the biosynthesis of gentamicin: isolation and characterization of a cobalamin-dependent radical SAM enzyme.
Kim HJ, McCarty RM, Ogasawara Y, Liu YN, Mansoorabadi SO, LeVieux J, Liu HW
Journal of the American Chemical Society 135(22) 8093-8096 2013年06月
Radical SAM enzymes in the biosynthesis of sugar-containing natural products.
Ruszczycky MW, Ogasawara Y, Liu HW
Biochimica et biophysica acta 1824(11) 1231-1244 2012年11月
A biosynthetic pathway for BE-7585A, a 2-thiosugar-containing angucycline-type natural product.
Sasaki E, Ogasawara Y, Liu HW
Journal of the American Chemical Society 132(21) 7405-7417 2010年06月
Biosynthesis of spinosyn in Saccharopolyspora spinosa: synthesis of permethylated rhamnose and characterization of the functions of SpnH, SpnI, and SpnK.
Kim HJ, White-Phillip JA, Ogasawara Y, Shin N, Isiorho EA, Liu HW
Journal of the American Chemical Society 132(9) 2901-2903 2010年03月
Biosynthetic studies of aziridine formation in azicemicins.
Ogasawara Y, Liu HW
Journal of the American Chemical Society 131(50) 18066-18068 2009年12月
Involvement of glutamate mutase in the biosynthesis of the unique starter unit of the macrolactam polyketide antibiotic vicenistatin.
Ogasawara Y, Kakinuma K, Eguchi T
The Journal of antibiotics 58(7) 468-472 2005年07月
Cloning, sequencing, and functional analysis of the biosynthetic gene cluster of macrolactam antibiotic vicenistatin in Streptomyces halstedii.
Ogasawara Y, Katayama K, Minami A, Otsuka M, Eguchi T, Kakinuma K
Chemistry & biology 11(1) 79-86 2004年01月

教育活動

主要な担当授業

応用化学学生実験Ⅲ
開講年度 : 2015年
課程区分 : 学士課程
開講学部 : 工学部
キーワード : 微生物の培養,微生物の観察,遺伝子工学,形質転換,大量発現,タンパク質精製
最新年度を全て表示する
主要な担当授業閉じる
応用化学学生実験Ⅲ
開講年度 : 2015年
課程区分 : 学士課程
開講学部 : 工学部
キーワード : 微生物の培養,微生物の観察,遺伝子工学,形質転換,大量発現,タンパク質精製

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