研究者データベース

川上 貴教(カワカミ タカノリ)
安全衛生本部
教授

基本情報

所属

  • 安全衛生本部

職名

  • 教授

学位

  • 博士(工学)(1998年03月 茨城大学大学院)

ホームページURL

J-Global ID

プロフィール

  • [保有資格等]
    第1種衛生管理者
    衛生工学衛生管理者
    有機溶剤作業主任者
    有機溶剤業務従事者教育インストラクター(中災防)
    特定化学物質等作業主任者
    特定化学物質等作業主任者能力向上教育インストラクター(中災防)
    酸素欠乏危険作業特別教育インストラクター(中災防)
    エックス線作業主任者
    第1種作業環境測定士(有機溶剤、特定化学物質、金属類)
    環境計量士(騒音・振動)(講習未受講、免許未登録)
    環境計量士(濃度)(講習受講済、免許未登録)
    公害防止管理者(水質1種、大気1種、ダイオキシン、騒音・振動)
    特別管理産業廃棄物管理責任者(一般特管、医療特管)
    エネルギー管理士(熱・電気)
    高圧ガス製造保安責任者(乙種化学、甲種化学:免許未登録)
    甲種危険物取扱者
    第2種電気工事士
    低圧電気取扱作業特別教育インストラクター(中災防)
    局所排気装置等定期自主検査者(静岡大学、筑波大学、名古屋大学)
    局所排気装置等定期自主検査インストラクター(中災防)
    労働衛生コンサルタント(労働衛生工学)

研究キーワード

  • 化学物質管理システム   環境保全   安全衛生   化学物質管理   

職歴

  • 2016年04月 - 現在 北海道大学 安全衛生本部 教授
  • 2012年10月 - 2016年03月 北海道大学 安全衛生本部 准教授
  • 2011年05月 - 2012年09月 北海道大学 安全衛生本部 特任准教授
  • 2001年10月 - 2011年04月 富山大学 水質保全センター 助手
  • 2001年04月 - 2001年09月 産業技術総合研究所 東北センター 研究員
  • 1998年04月 - 2001年03月 通商産業省工業技術院東北工業技術研究所 機能化学部 研究員

学歴

  • 1995年04月 - 1998年03月   茨城大学大学院   博士後期課程 理工学研究科   物質科学専攻
  • 1993年04月 - 1995年03月   茨城大学大学院   博士前期課程 工学研究科   物質工学専攻
  • 1988年04月 - 1993年03月   東北大学   工学部   分子化学工学科
  • 1985年04月 - 1988年03月   栃木県立宇都宮高等学校

所属学協会

  • 化学防護手袋研究会   日本労働衛生工学会   日本産業衛生学会   大学等環境安全協議会   日本分析化学会   日本化学会   

研究活動情報

論文

  • 中村 修, 川上 貴教, 武藤 一, 大泉 学, 片岡 裕一
    環境と安全 6 1 25 - 29 Academic Consociation of Environmental Safety and Waste Management, Japan 2015年03月 [査読有り][通常論文]
     
    実験系廃液は、ひとたび取り扱いを誤ると、事故や環境汚染のリスクが著しく大きくなる。廃液処理とは、廃液の化学物質としてのリスクを除去することである。これには無害化処理の様な技術面だけでなく、構成員への教育の様な運用面の活動も含まれる。リスクの低減の最も大きな因子は、構成員及び廃液処理担当者が当事者意識を持つことである。 また、廃液管理活動を通じて、化学の負の側面を知る真に環境配慮が出来る人材を養成することも、大学等が果たすべき使命と考える。 大学等において、実験系廃液の無害化処理形態に自家処理と外注処理が有るが、廃液に係るリスクの除去と言う活動の本質において、両者に大差はない。 自家処理の場合は教育及び人材育成の効果が顕著でありそれが廃液を含む実験系廃棄物全体のリスクの低減につながる点が有利である。 その一方で、外注処理は労力と費用を削減すればするほど構成員および担当者の意識を保つことが難しいので、意識が低下しないように注意が必要である。廃液管理を適切に行う事で、廃棄物管理全体の管理も容易になる。
  • Shigeru Taguchi, Miyabi Asaoka, Eiko Hirokami, Noriko Hata, Hideki Kuramitz, Takanori Kawakami, Ryuta Miyatake
    ANALYTICAL METHODS 7 16 6545 - 6551 2015年 [査読有り][通常論文]
     
    A simple and rapid pre-concentration technique was proposed for the simultaneous determination of eight trace heavy metals in water by energy-dispersive X-ray fluorescence (EDXRF) spectrometry. Yttrium was added as a carrier ion to a sample solution containing Cd, Cr, Cu, Fe, Mn, Ni, Pb and Zn. The metals were collected on a membrane filter as precipitates or co-precipitates with 1-(2-pyridylazo)-2-naphthol at pH 10. The metals on the filter were determined by EDXRF spectrometry. Yttrium improved the collection efficiency of Cr(III) drastically and also expanded the pH ranges for quantitative recoveries of the metals. Only fifteen minutes was required to prepare the membrane filter retaining the metals. Linear calibrations were obtained from mu g L-1 to mg L-1 levels of the metals in 50 mL sample solution. The limits of detection were as follows: Cd, 1 mu g L-1; Cr, 0.3 mu g L-1; Cu, 1 mu g L-1; Fe, 1 mu g L-1; Mn, 0.3 mu g L-1; Ni, 2 mu g L-1; Pb, 2 mu g L-1; and Zn, 2 mu g L-1. The sensitivities were sufficient for monitoring drinking water. The proposed method was applied to river water and underground water samples. The analytical results agreed with those obtained by GF-AAS for the detected metals. The recoveries of the spiked metals in the water samples were quantitative. This method was extended to the separation and determination of Cr(III) and Cr(VI). The proposed system of pre-concentration and EDXRF spectrometry has high potential for routine monitoring of trace heavy metals because of its simplicity and rapidity besides cost-effectiveness.
  • Sazawa, Kazuto, Tachi, Masaki, Wakimoto, Takatoshi, Kawakami, Takanori, Hata, Noriko, Taguchi, Shigeru, Kuramitz, Hideki
    INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 8 5 1655 - 1670 2011年05月 [査読有り][通常論文]
     
    The dissolved organic matter (DOM) is one of the important factors for controlling water quality. The behavior and constitutions of DOM is related to the risk of human health because it is able to directly or indirectly affect the behavior, speciation and toxicity of various environmental pollutants. However, it is not easy to know the contents of DOM components without using various complicated and time consuming analytical methods because DOM is a complex mixture and usually exists at low concentration. Here, we describe the fluorescence properties of DOM components in water samples collected from four rivers in Toyama, Japan by means of the three-dimensional excitation-emission matrix (3DEEM) fluorescence spectroscopy. In order to evaluate the alterations of DOM components in each of the river during the flow from upstream to downstream, the patterns of relative fluorescence intensity (RFI) at six peaks which are originated from fluorophores including humic-like and protein-like components were investigated. The changes in the patterns of RFI values at each of the peak and the concentration of dissolved organic carbon (DOC) for each river water sample were discussed in connection with the differences of land use managements and basic water quality parameters, such as pH, EC, turbidity, Fe(3+), T-N, NO(3)-N, T-P, PO(4)-P, chlorophyll a, DOC and N/P ratio. The DOC concentrations in the water samples collected from these rivers were relatively low (0.63-1.16 mg/L). Two main peaks which have a strong RFI value expressed a positive correlation with the DOC concentration (r = 0.557, 0.535). However, the correlations between the RFI values for other four peaks and the DOC concentration were below 0.287. The alterations of DOM components during the flow of a river from upstream to downstream were investigated from the changes in the patterns of RFI values for six fluorescent peaks. It was clarified that the great increase of RFI values in peak A and peak T from river water located in urban area showed high concentration of PO(4)-P and Fe(3+), and low N/P ratio due to the high biological activities. The values of fluorescence index (FIX) and biological index (BIX) were as high as 1.60 and 0.72, respectively.
  • 川上 貴教
    環境と安全 1 2 25 - 31 Academic Consociation of Environmental Safety and Waste Management, Japan 2010年 [査読有り][通常論文]
     
    2005~2009年度の富山大学五福地区での不要試薬取引について、リレーショナルデータベース型化学薬品管理システムによるデータ収集結果を元に調査を行った。   5年間で635件の不要試薬公開があり、そのうち30.7%の195件の取引が成立した。それにより\1,044,814の費用節約効果が得られた。約4割の研究室は不要試薬取引所を利用しており、退官する教員の試薬が大量出品されたり、有機合成化学系の研究室が積極的に引き取る傾向がみられた。なお、85%の取引は部局内ではなく異部局間で行われた。引取りを待つ期間としては約2ヶ月が適当であり、それ以上は廃棄手続をするのが望ましい。使用している研究室の数と、取引成立率には一定の相関がみられた。特に洗浄や中和に使われる有機溶媒や酸アルカリはよく引き取られた。また、未開封であることは有利な条件であった。
  • 倉光 英樹, 佐澤 和人, 七山 泰昭, 工藤 千春, 川上 貴教, 波多 宣子, 田口 茂
    水環境学会誌 = Journal of Japan Society on Water Environment 32 6 309 - 314 Japan Society on Water Environment 2009年06月 [査読有り][通常論文]
     
    Dissolved organic matter (DOM) significantly relates to the speciation of heavy-metal ions in aquatic environments. To evaluate the toxicity changes of heavy-metal ions induced by the existence of DOM or dissolved humic substances (DHS), a microscaled algal growth inhibition (μAGI) test was conducted using a commercially available 96-well micro-plate. The μAGI test was compared with a regular AGI test using an Erlenmeyer flask. A regular AGI test is not very beneficial for accessing the toxicity of chemicals in an aqueous solution containing DOM or DHS because it absorbs visible light, which is required for algal growth. However, in this study, we clarified that the amount of algal growth in the μAGI test is hardly affected even at a high DHS concentration. The changes in the toxicity of copper to Chlamydomonas reinhardtii were evaluated under two conditions of the μAGI test, that is, with and without DOM/DHS. DOM and DHS samples were extracted from freshwater samples from Sakata in Niigata prefecture, Japan. The toxicity mitigation coefficients (TMCs) at 10 mgC · <I>l</I>-1 DOM and DHS were estimated to be 1.4-2.7 and 4.8, respectively. Evidence found in this study shows that DHS strongly reduces the toxicity of copper (II) to algae, as compared with nonhumic components in DOM.
  • Keita Murai, Mayumi Okano, Hideki Kuramitz, Noriko Hata, Takanori Kawakami, Shigeru Taguchi
    ANALYTICAL SCIENCES 24 11 1455 - 1459 2008年11月 [査読有り][通常論文]
     
    A simple and sensitive spectrophotometry for formaldehyde in water by membrane solubilization technique was proposed. Formaldehyde was converted into a blue cationic dye with 3-methyl-2-benzothiazolinone hydrazone, and the dye was retained on a membrane filter as an ion-associate with tetraphenylborate anion. The filter retaining the blue dye was dissolved in 2-methoxyethanol containing sulfuric acid, and the absorbance of the solution was measured at 670 nm against the reagent blank. The formaldehyde from 0.007 to 0.2 mg L-1 was determined with an RSD of less than 5%, and the detection limit was 0.002 mg L-1. The proposed method was very simple and rapid. Twenty minutes was sufficient for the entire analytical procedure. When the method was applied to rainwater, the analytical results were in good agreement with those obtained by GC/MS.
  • Hiroyuki Higuchi, Naoto Hayashi, Takuya Matsukihira, Takanori Kawakami, Toru Takizawa, Junji Saito, Keiko Miyabayashi, Mikio Miyake
    HETEROCYCLES 76 1 353 - 380 2008年09月 [査読有り][通常論文]
     
    The octaethylporphyrin (OEP)-dihexylbithiophene (DHBTh) derivatives combined with pyridine (Pyr) and pyrimidine (Pym) as proton-acceptable rings (PAR) were synthesized, describable as OEP-DHBTh-PAR, in which all the OEP, DHBTh, and PAR components are connected with diacetylene linkage. Their (1)H NMR and electronic spectral properties and electrochemical behaviors were studied under the neutral and acidic conditions. Reversible proton-mediated and heat-driven spectral changes of OEP- DHBTh-PAR were performed, reflecting both properties of PAR and DHBTh.
  • K. Murai, M. Okano, H. Kuramitz, N. Hata, T. Kawakami, S. Taguchi
    WATER SCIENCE AND TECHNOLOGY 58 5 1055 - 1060 2008年 [査読有り][通常論文]
     
    The pollution of tap water and rain water with formaldehyde in Toyama Pref., Japan was investigated by means of a simple, rapid and cost-effective visual colorimetry developed by us. The levels of formaldehyde in three tap waters from different sources of dams on mountainside and a well-water pumped in urban area in Toyama Pref. were lower than 0.01 mgL(-1) that was the detection limit of the colorimetry. On the other hand, rain waters were seriously polluted with formaldehyde. Rain waters were sampled from three different sites (urban area, top of hill and industrial area) in Toyama Pref. from autumn to winter in 2006. The levels of formaldehyde in the rain waters ranged from 0.07 to 0.30 mgL(-1). The analytical results by the visual colorimetry were in good agreement with those obtained by GC-MS method. It was confirmed that the colorimetry is excellent for practical use for the determination of formaldehyde. It must be concerned about the pollution of rainwater with formaldehyde, when rain water is applied for tap water and miscellaneous purpose.
  • Shigeyasu Kuroda, Mitsunori Oda, Hiroaki Takamatsu, Hirofumi Hatakeyama, Chisa Noda, Yanmei Zhang, Ryuta Miyatake, Nguyen Chung Thanh, Atsusi Yanagida, Mayumi Kyougoku, Takanori Kawakami
    SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS 8 4 306 - 317 2007年05月 [査読有り][通常論文]
     
    Two types of polycyclic quinones condensed with 1,6-methano[10]annulenes as type A: 1,6-methanonaphtho[2,3-c][10]annulene-7,12-dione 5a, and type 13: 1,6-methanonaphtho[2,3-c][10]annulene-5,14-dione 18, bis(1,6-methano[10]annuleno[3,4-b; 3,4-g])anthracene10,21-dione 20, 1,6-methanoanthraceno[2,3-c][10]anntilene-5,16-dione 22, 1,6-methanotetraceno[2,3-c][10]annulene-6,17-dione 23, and 1,6-methano phenanthreno[2,3-c][10]annulene-5,6-dione 24 have been synthesized. The acene derivative 6 corresponding to that of 5a was synthesized by the reduction of quinone 5a. The physical, spectral, and chemical properties of these new compounds have been investigated. (C) 2007 NIMS and Elsevier Ltd. All rights reserved.
  • 五十嵐 淑郎, 川上 貴教
    ぶんせき 327 114 - 119 日本分析化学会 2002年03月 [査読有り][通常論文]
  • New Molecular Design of Porphyrin as an Ultra-highly Sensitive Chromogenic Reagent using Disappearance of Soret Band and Its Applications to Biological and Environmental Samples
    Takanori Kawakami, Shukuro Igarashi
    IUPAC International Congress on Analytical Science 209-210  2001年08月 [査読無し][通常論文]
  • 金久保 光央, 相沢 崇史, 川上 貴教
    東北工業技術研究所報告 34 77 - 86 東北工業技術研究所 2001年02月 [査読有り][通常論文]
  • Y Ikushima, K Hatakeda, O Sato, T Aizawa, M Kanakubo, T Kawakami, N Saito
    HIGH PRESSURE RESEARCH 20 1-6 155 - 166 2001年 [査読有り][通常論文]
     
    Significant acceleration of Beckmann and pinacol rearrangements can be achieved by using supercritical water (scH(2)O), especially just near the critical point even in the absence of any acid catalysts. A high-pressure, high-temperature flow reactor system with FTIR operable at 500degreesC and 50 MPa was successfully developed, wherein the noncatalytic Beckmann and pinacol rearrangements using scH(2)O Were carried out and monitored. It has been demonstrated that scH(2)O itself acts very effectively in the place of conventional acid catalysts for both the rearrangements. The rate of the pinacol rearrangement using scH(2)O is 28,200-fold rate of that in 0.871 M HCl solution at 46.7 MPa under distillation conditions. The high rate of reaction may be attributed to a great increase in the local proton concentration around the organic reactants.
  • Mitsuhiro Kanakubo, Chee C. Liew, Takafumi Aizawa, Takanori Kawakami, Osamu Sato, Yutaka Ikushima, Kiyotaka Hatakeda, Norio Saito
    Chemistry Letters 1320 - 1321 2000年12月 [査読有り][通常論文]
     
    1H NMR longitudinal relaxation times (T1 obs) of water in supercritical carbon dioxide were precisely measured as a function of water concentration (c) at 313.3 K and at 10 and 20 MPa. I/T1,obs linearly decreased with increasing c up to ∼ 12 mol m-3, and then was less sensitive to c. Because the spinrotation interaction is the predominant mechanism in T1 obs, the concentration dependence reflects a change in the hydrogen bonding structure between water molecules in the solutions.
  • T Kawakami, N Saito, Y Ikushima, CC Liew, K Aiba, T Ohkawa
    CHEMISTRY LETTERS 4 402 - 403 2000年04月 [査読有り][通常論文]
     
    We have developed a new series of branch-structured anionic surfactants dissolved significantly well in sc-CO2. We found that, the variation of counter ion species has a significant effect on the solubility of the surfactants in sc-CO2. Among these, the solubility of surfactant with ammonium ion exceeded 16 wt% at 40 degrees C and 15 MPa while that of surfactant with K+ was neglectable. This effect can be used for complete recovery of the surfactant.
  • M Kanakubo, T Aizawa, T Kawakami, O Sato, Y Ikushima, K Hatakeda, N Saito
    JOURNAL OF PHYSICAL CHEMISTRY B 104 12 2749 - 2758 2000年03月 [査読有り][通常論文]
     
    A newly designed high-pressure NMR flow cell has been developed for studies of supercritical fluids. By using the high-pressure cell, H-1 chemical shifts of nonpolar (n-hexane and benzene) and polar (dichloromethane, chloroform, acetonitrile, water, methanol, and ethanol) solute molecules in gaseous and supercritical carbon dioxide were measured in the wide pressure range between 2 and 30 MPa at 313.3 K. The chemical shifts of hydroxyl protons of water, methanol, and ethanol in carbon dioxide at 20.0 MPa were shifted to higher frequency due to intermolecular hydrogen bonding with increasing concentration. A comparison of the concentration dependence with relevant data in carbon tetrachloride indicated a specific interaction between alcohol and carbon dioxide molecules. The corrected H-1 chemical shifts of nonpolar and polar solute molecules at infinite dilution, where the bulk magnetic susceptibility contribution was subtracted, were shifted to higher frequency with increasing density of carbon dioxide. The observed density dependence, represented by a polynomial equation of the third power of density, was interpreted in terms of three distinct density regions, i.e., gaslike, intermediate, and liquidlike. In the gaslike and liquidlike states the solvation structure rapidly varies as the bulk density increases, whereas in the intermediate state the solvation structure remains almost unchanged despite the drastic change in the bulk density. It was demonstrated that the H-1 chemical shift is quite a sensitive probe to a variation of surroundings. The solvent-induced H-1 chemical shifts were analyzed on the basis of two different models.
  • Mitsuhiro Kanakubo, Takafumi Aizawa, Takanori Kawakami, Osamu Sato, Yutaka Ikushima, Kiyotaka Hatakeda, Norio Saito
    Journal of Physical Chemistry B 104 2749 - 2758 2000年03月 [査読有り][通常論文]
     
    A newly designed high-pressure NMR flow cell has been developed for studies of supercritical fluids. By using the high-pressure cell, 1H chemical shifts of nonpolar (n-hexane and benzene) and polar (dichloromethane, chloroform, acetonitrile, water, methanol, and ethanol) solute molecules in gaseous and supercritical carbon dioxide were measured in the wide pressure range between 2 and 30 MPa at 313.3 K. The chemical shifts of hydroxyl protons of water, methanol, and ethanol in carbon dioxide at 20.0 MPa were shifted to higher frequency due to intermolecular hydrogen bonding with increasing concentration. A comparison of the concentration dependence with relevant data in carbon tetrachloride indicated a specific interaction between alcohol and carbon dioxide molecules. The corrected 1H chemical shifts of nonpolar and polar solute molecules at infinite dilution, where the bulk magnetic susceptibility contribution was subtracted, were shifted to higher frequency with increasing density of carbon dioxide. The observed density dependence, represented by a polynomial equation of the third power of density, was interpreted in terms of three distinct density regions, i.e., gaslike, intermediate, and liquidlike. In the gaslike and liquidlike states the solvation structure rapidly varies as the bulk density increases, whereas in the intermediate state the solvation structure remains almost unchanged despite the drastic change in the bulk density. It was demonstrated that the 1H chemical shift is quite a sensitive probe to a variation of surroundings. The solvent-induced 1H chemical shifts were analyzed on the basis of two different models. © 2000 American Chemical Society.
  • New Molecular Design of Porphyrin as an Ultra highly Sensitive Chromogenic Reagent and its Applications to Biological and Environmental Samples
    T. Kawakami, S. Igarashi
    5th Chemical Congress of North America 743  1997年11月 [査読無し][通常論文]
  • T Kawakami, S Igarashi
    ANALYTICA CHIMICA ACTA 354 1-3 159 - 161 1997年11月 [査読有り][通常論文]
     
    The asymmetric porphyrin derivative having only one reaction site, A(1)Py(3)P [5-(4-aminophenyl)-10,15,20-tris(4-pyridyl)porphine], was synthesized [epsilon=2.1 x 10(5) M-1 cm(-1) (pH 1.0, at 441 nm)]. UV, IR and mass spectral measurements, elemental analysis and thin layer chromatography were carried out for identification of A(1)Py(3)P. It was demonstrated that the porphyrin reacted with nitrite in a mole ratio of 1 : 1, giving a useful spectral change. The spectrophotometric determination of nitrite using A(1)Py(3)P was excellent with respect to calibration linearity: 0-8.0 x 10(-7) M, detection limit (3 sigma): 7.0 x 10(-9) M, relative standard deviation: 1.0%, for 10 determinations at 4.0 x 10(-7) M. (C) 1997 Elsevier Science B.V.
  • T Kawakami, K Honda, S Igarashi
    CHEMICAL & PHARMACEUTICAL BULLETIN 45 8 1376 - 1378 1997年08月 [査読有り][通常論文]
     
    A water-soluble porphyrin having four aminophenyl groups 5,10,15,20-tetrakis(4-aminophenyl)porphine (TAPP) diazotizes with nitrite ion and produces a large spectral change (epsilon: molar absorptivity, Delta epsilon=epsilon(sample)-epsilon(blank)=3.0 x 10(5) M-1 cm(-1), 434 nm), The coexistence of L-ascorbic acid (AsA) strongly interferes with this reaction, Therefore, a highly sensitive spectrophotometric determination of AsA was developed using this effect, For the determination of trace amounts of AsA, the calibration curve was linear in the concentration range of 8.0 x 10(-8)M-5.0 x 10(-7) M (14-88 ppb), The detection limit (3 sigma) was 1.0 x 10(-8) M (1.76 ppb), and the relative standard deviation was 1.86% (2.0 x 10(-7) M (35 ppb) AsA, 6 determinations). This method is more than 20 times highly-sensitive than the indophenol method as standard spectrophotometry for AsA. This method has been applied to the determination of AsA in soft drinks and drugs.
  • T Kawakami, S Igarashi
    ANALYTICA CHIMICA ACTA 333 1-2 175 - 180 1996年10月 [査読有り][通常論文]
     
    A water-soluble porphyrin having the aminophenyl group, 5,10,15,20-tetrakis(4-aminophenyl)porphine, reacts with nitrite ion, and produces a large spectral change (Delta epsilon = 3.0 x 10(5) l mol(-1) cm(-1), 434 nm). There are few interfering substances and it is easy to establish the reaction conditions because the spectral change mechanism is based only on diazotization. A highly sensitive spectrophotometric determination of nitrite was developed on this basis. The calibration graph was linear in the range 0 to 4.0 x 10(-7) mol l(-1) (0-18 ng ml(-1)). The detection limit {S/N = 3} was 4.0 x 10(-9) mol l(-1) (0.18 ng ml(-1)), and the relative standard deviation was 1.0% (at 2.0 x 10(-7) mol l(-1) nitrite, 10 determinations). This method has been applied to the determination of nitrite in rain, tap and spring water without any pretreatment.
  • 川上 貴教, 五十嵐 淑郎
    分析化学 45 1 91 - 93 公益社団法人日本分析化学会 1996年01月 [査読有り][通常論文]
     
    A highly sensitive spectrophotometric determination (Δε=ε<SUB>blank</SUB>-ε<SUB>sample</SUB>=3.0 ×10<SUP>5</SUP>l mol<SUP>-1</SUP> cm<SUP>-1</SUP>) for nitrite ion using 5, 10, 15, 20-tetrakis(4-aminophenyl)porphine (TAPP) was developed. This method is based only on the formation of the diazonium salt. Recommended procedure: A 2.0 ml aliquot of 10<SUP>-5</SUP> mol/l TAPP solution and 2.5 ml aliquot of 1.0 mol/l HCl were mixed, the sample solution containing nitrite ion added and the volume then made up to 25 ml with water. After 30 min at 30°C, the absorbance at 434 nm was measured. The determination range was 1.0 × 10<SUP>-8</SUP>4.0× 10<SUP>-7</SUP> mol/l (0.4618 ppb) and the detection limit (<I>S</I>/<I>N</I>= 3) was 4.0 × 10<SUP>-9</SUP> mol/l (0.18 ppb). The relative standard deviation of the median was 1.03% (10 determinations). This simple method will be applicable to various assays such as environmental analysis and clinical diagnosis.
  • Water&soluble Porphyrin Derivatives as MRI Reagents for Arteriosclerosis
    Takanori Kawakami, Shukuro Igarashi
    International Chemical Congress of Pacific Basin Societies 403  1995年12月 [査読無し][通常論文]
  • A Kinetic Spectrophotometric Determination of 10-12 M Levels of Alkaline Phosphatase using New Water–soluble Porphyrin and its Application to Enzyme Immunoassay
    Takanori Kawakami, Shukuro Igarashi
    Oak Ridge Conference 31  1995年04月 [査読無し][通常論文]
  • Takanori KAWAKAMI, Shukuro IGARASHI
    The Analyst 120 2 539 - 542 1995年02月 [査読有り][通常論文]
     
    A highly sensitive kinetic spectrophotometric determination for alkaline phosphatase (ALP) using 5,10,15,20-tetrakis (4-phosphonooxyphenyl)porphine (approximately Delta epsilon approximate to 3.0 x 10(5) I mol(-1) cm(-1)) was studied. With a measuring time of 30 min, the determination range was 2.0 x 10(-12)-8.0 X 10(-9) mol l(-1) and the detection limit (3s) was 1.0 x 10(-12) mol l(-1). The detection limit became lower on increasing the measuring time, For example, the detection limit was up to 10(-15) mol l(-1) for 12 h. This method was applied to the assay of ALP in human serum. Using 0.50 ml of sample without any pre-treatment, a good correlation was obtained with the p-nitrophenyl phosphate method, and the relative standard deviation was 4.7%. The method was also applied to the enzyme immunoassay of alpha-fetoprotein in human serum and provided a good correlation with the 4-methylumbelliferone derivative (r = 0.999) with approximately half the relative standard deviations (1.3-2.7%) obtained with a commercial kit. The proposed method requires very small sample volumes, is highly sensitive, highly accurate, and shows good stability of the reagent; it will be applied to various assays using ALP as label.
  • Shukuro Igarashi, Hiroyasu Furukawa, Takanori Kawakami
    Analytical Proceedings including Analytical Communications 32 3 107 - 109 1995年 [査読有り][通常論文]
     
    New water-soluble porphyrins having fluorine groups i.e., 5,10,15,20-tetrakis(2-fluorosulfophenyl)porphine, 5,10,15,20-tetrakis(2,6- difluorosulfophenyl)porphine and 5,10,15,20-tetrakis(2,3,5,6,- tetrafluorosulfophenyl)porphine (TF< inf> 4< /inf> SP) have been synthesised and characterized. Moreover, the spectrophotometric determination of 10< sup> -7< /sup> mol dm< sup> -3< /sup> levels of lead(II) ion using TF< inf> 4< /inf> SP has been demonstrated (ε< inf> Pb-TF< /inf> 4< inf> SP< /inf> = 20 × 10< sup> 4< /sup> mol< sup> -1< /sup> dm< sup> 3< /sup> cm< sup> -1< /sup> reaction time, 2 min at 25 °C and pH =9).
  • 五十嵐 淑郎, 荒井 貴史, 川上 貴教
    分析化学 43 12 1183 - 1188 公益社団法人日本分析化学会 1994年12月 [査読有り][通常論文]
     
    水-酢酸-クロロホルム三成分系において, pH依存相分離現象を利用した新しい均一液-液抽出法を開発した.まず, 三成分溶媒系の相分離における最適操作条件を決定した{クロロホルム230μl(0.66vol%)と酢酸2cm^3(5.71vol%)を含む均一水溶液に水酸化ナトリウム水溶液([NaOH]_T=1.03mol dm^<-3>)を添加し相分離を行う.最終体積 : 35cm^3}.又, あらかじめ添加するクロロホルムの量を調節することにより, 水相(V_w=35cm^3)と析出相(V_o=3.5μl)との体積比を一万倍とすることができた.モデル溶質としてα, β, γ, δ-テトラキス(4-ピリジル)ポルフィンを選定し, 本法を適用した結果, V_w/V_oが700のとき, 分配比(D)は5600及び抽出率(E)は88.9%であった.更に, 本法と8-キノリノール比色法を組み合わせた均一液-液抽出法では, 飲料水中の鉄の定量に対し, 良好な結果が得られた{鉄(III)-8-キノリノール錯体 : V_w/V_o=700のとき, D=1230及びE=63.7%}.
  • 川上 貴教, 五十嵐 淑郎
    日本化学会誌 1994 4 396 - 398 The Chemical Society of Japan 1994年04月 [査読有り][通常論文]
     
    In order to obtain an imaging diagnostic agent which adsorbs selectively to atheroma, three kinds of [tetrakis (phosphonooxyphenyl)porphyrinato]manganese (III) were synthesized. Namely, they ar e manganese (III) complexes of 5, 10, 15, 20-tetrakis [4- (phosphonooxy) phenyl]porphyrin [Mn (tPPPm)5, 10, 15, 20-tetrakis [3, 4-bis (phosphonooxy) phenyl] porphyrin [Mn (OPPd) 1, and 5, 10, 15, 20 -tetrakis [3, 4, 5-tris (phosphonooxy)phenyl]PorPhYrin [Mn(tPPPt)] (Fig.1). Among these, [Mn(tPPPd)] adsorbed well to calcium carbonate (rate of adsorption: 48%) and [Mn(tppt)]adsorbed well to deoxycholic acid (rate of adsorption: 54%).
  • T KAWAKAMI, S IGARASHI
    ANALYTICAL LETTERS 27 11 2083 - 2089 1994年 [査読有り][通常論文]
     
    A new water-soluble porphyrin having the phosphate group, 5,10,15,20-tetrakis(4-phosphonooxyphenyl)porphine, was used as an ultra highly-sensitive chromogenic reagent of alkaline phosphatase enzyme activity. In the spectrophotometric determination of trace amounts of alkaline phosphatase with this reagent, the calibration curve was linear in the concentration range of 3.2 x 10(-5) to 6.4 x 10(-4) g/l and detection limit {S/N=3} of alkaline phosphatase was 8.0 X 10(-8) g/l (10(-12)M) for 30 min and the relative standard deviation was 3.5% (2.0 X 10(-5) g/l ALP, 10 determinations). This reagent was also stable for seven days in aqueous solution (37 degrees C, pH=9.4).
  • 五十嵐 淑郎, 神澤 義仁, 川上 貴教, 四ッ柳 隆夫, 金 尚元, 小塚 隆弘
    日本化学会誌 1993 2 184 - 188 公益社団法人 日本化学会 1993年 [査読無し][通常論文]
     
    動脈硬化症病変部に特異性を有する新規NMRイメージング造影剤の開発を目的として,8種類のマンガン(III)-テトラキス(スルボアリール)ポルフィリン誘導体を合成した。スルホビフェニリル基を有するマンガン(III)-α,β,γ,δ-テトラキス(4-スルホビフェニリル)ポルフィリン(Mn-TSBP)は,水に対する溶解性(溶解度:5×10-3mol dm-3),錯体のpH安定性(pH1.5~13.5の範囲で安定),およびデオキシコール酸担体への吸着特性などの点で優れていた。動脈硬化症ウサギを作成し,合成した水溶性ポルフィリン錯体を投与した結果,Mn-TSBPは正常部組織よりも病変部組織に2倍以上選択的に吸着した。
  • 五十嵐 淑郎, 神澤 義仁, 川上 貴教, 四ツ柳 隆夫, 金 尚元, 小塚 隆弘
    日本化学会誌 : 化学と工業化学 = Journal of the Chemical Society of Japan : chemistry and industrial chemistry 1993 2 184 - 188 日本化学会 1993年 [査読有り][通常論文]
     
    動脈硬化症病変部に特異性を有する新規NMRイメージング造影剤の開発を目的として,8種類のマンガン(III)-テトラキス(スルボアリール)ポルフィリン誘導体を合成した。スルホビフェニリル基を有するマンガン(III)-α,β,γ,δ-テトラキス(4-スルホビフェニリル)ポルフィリン(Mn-TSBP)は,水に対する溶解性(溶解度:5×10-3mol dm-3),錯体のpH安定性(pH1.5~13.5の範囲で安定),およびデオキシコール酸担体への吸着特性などの点で優れていた。動脈硬化症ウサギを作成し,合成した水溶性ポルフィリン錯体を投与した結果,Mn-TSBPは正常部組織よりも病変部組織に2倍以上選択的に吸着した。

書籍

  • (担当:分担執筆範囲:第14章 実験室廃棄物の取扱い)
    日本食品衛生協会 2015年02月 (ISBN: 4889250719) 1376
  • 柏木保人, 金澤浩明, 川上貴教, 中山政勝, 野本信也, 塙浩之, 宮本和明, 藤村久 (担当:共著)
    局所排気装置の維持管理研究会 2014年08月 (ISBN: 4908045003) 112
  • 実験者/試験検査員の誤ったデータの取扱い・試験誤操作防止策
    (担当:分担執筆範囲:第13章 第1節 試薬の取扱に関する法令と実務対応)
    技術情報協会 2014年03月 (ISBN: 9784861045189) 592

作品等

  • 富山大学薬品管理支援システム
    川上 貴教  2002年06月 -2011年04月
  • TULIP
    川上 貴教  2002年04月 -2011年04月

その他活動・業績

  • 川上貴教, 柏木保人, 金澤浩明, 中村修, 中山政勝, 野本信也, 塙浩之, 藤井邦彦, 宮本和明 環境と安全 6 (1) 48 -51 2015年03月 [査読無し][通常論文]
     
    局所排気装置(以下、局排)には性能維持のために定期的なメンテナンスが必要である。それにも関わらず充分な維持管理体制が整っている大学は多くない。局排の適切なメンテナンスを行うためには、大学側に局排について一定の知識が必要となる。そこで、先行して局排に取り組んできた静岡大学、茨城大学、筑波大学を中心とした有志により、大学向けの局排維持管理の解説書を作成した。また、そのメンバーを中心に局所排気装置の維持管理研究会が発足した。大学間での連携協力体制も構築でき、各大学における局排維持管理の取組みが盛んになることを期待する。
  • 化学物質関連法規制の有無と自主管理のススメ
    川上 貴教 環境と安全 4 (1) 74 -74 2013年03月 [査読無し][通常論文]
  • 藤井 邦彦, 中村 修, 中山 政勝, 川上 貴教 環境と安全 4 (3) 237 -246 2013年 [査読無し][通常論文]
     
    大学等の研究機関の多くは、機関内の適切な試薬の管理を目指して、クライアントサーバ型の化学物質管理システムを導入し、試薬類の一元管理を行っている。しかし、これまで各大学等におけるシステムの導入・運用状況、メンテナンス・管理体制、および運用上の問題点については、不明な部分が多かった。<br> 本報告では、国立大学法人を主とする各大学等における化学物質管理システムの運用管理状況についてアンケートによる実態調査を行った。その結果、各大学等のシステムの運用における人員構成・配置、管理体制等が明らかとなった。特に、試薬マスタの管理に関しては、マスタ総登録件数、更新頻度、メンテナンス体制などの管理ポリシーが大学等によって大きく異なっていることが明らかとなった。
  • 川上 貴教 ぶんせき (446) 64 -72 2012年02月05日 [査読有り][通常論文]
     
    1.毒物及び劇物取締法
    2.消防法
    3.労働安全衛生法および関連法
    4.おわりに
  • 川上 貴教 ぶんせき (445) 2 -10 2012年01月05日 [査読有り][通常論文]
     
    1.試薬と法規制
    2.廃棄物の処理及び清掃に関する法律
    3.水質汚濁防止法,下水道法
    4.特定化学物質の環境への排出量の把握等及び管理の改善の促進に関する法律
  • 川上 貴教 ぶんせき (418) 560 -561 2009年10月05日 [査読有り][通常論文]
  • 川上 貴教 ぶんせき (371) 607 -608 2005年11月05日 [査読有り][通常論文]
  • 川上 貴教 ぶんせき (369) 502 -503 2005年09月 [査読有り][通常論文]
  • 川上 貴教 ぶんせき (349) 2004年01月05日 [査読有り][通常論文]
  • 川上 貴教 富山大学総合情報基盤センター広報 1 89 -94 2004年 [査読無し][通常論文]
     
    富山大学薬品管理支援システムTULIPの開発について紹介する。

特許

  • 特開2000-254405:二酸化炭素媒体中で用いる界面活性剤  2000年09月19日
    川上貴教, 斉藤功夫, 畑田清隆, 生島豊, 佐藤修, 相澤崇史, 金久保光央, 大川直士, 饗羽啓三
  • 特開2000-241518:流通式高圧NMRセル精密温度制御システム  2000年09月08日
    金久保 光央, 相澤 崇史, 川上貴教, 佐藤 修, 生島 豊, 畑田 清隆, 斉藤 功夫
  • 特開2000-210550:光化学反応観測用反応セル  2000年08月02日
    相澤 崇史, 斎藤 功夫, 畑田 清隆, 生島 豊, 佐藤 修, 金久保 光央, 川上貴教
  • 特開平9-110872:ヨードポルフィリン誘導体  1997年04月28日
    五十嵐 淑郎, 川上 貴教, 森川 惇二, 高野 弘
  • 特開平9-089781:亜硝酸イオン濃度測定方法  1997年04月04日
    五十嵐 淑郎, 川上貴教
  • 特開平7-082285:ポルフィリン・リン酸エステル誘導体  1995年03月28日
    五十嵐 淑郎, 川上 貴教, 森川 惇二

受賞

  • 2009年11月 大学等環境安全協議会 技術賞
     
    受賞者: 川上 貴教
  • 2001年04月 文部科学省 第60回注目発明賞
     超臨界二酸化炭素中で用いる界面活性剤の開発 
    受賞者: 川上貴教;斉藤功夫;畑田清隆;生島豊;佐藤修;相澤崇史;金久保光央
  • 1999年03月 日本化学会 第76春季年会 ポスター賞(材料の応用部門)
     超臨界二酸化炭素中での逆ミセル形成を目的としたフッ素系界面活性剤の開発 ~対イオンによる影響~ 
    受賞者: 川上貴教;斉藤功夫;畑田清隆;生島豊;佐藤修;相澤崇史;金久保光央
  • 1998年03月 日本化学会 第74春季年会ポスター賞(分析化学部門)
     多段階の酸解離特性を有するカチオン性ポルフィリンの吸収スペクトル変化とオプティカルpHセンサーへの応用 
    受賞者: 酒井睦子;川上貴教;五十嵐淑郎

教育活動情報

主要な担当授業

  • 大学院共通授業科目(一般科目):自然科学・応用科学
    開講年度 : 2018年
    課程区分 : 修士課程
    開講学部 : 大学院共通科目
    キーワード : 環境保全、公害防止、廃棄物処理、安全衛生、安全配慮義務、CSR、リスクアセスメント、事故事例、法規制、資格・制度

大学運営

委員歴

  • 2018年04月 - 現在   帯広畜産大学   化学物質等管理委員会 委員
  • 2015年07月 - 現在   大学等環境安全協議会   評議員
  • 2015年04月 - 現在   北海道大学   安全衛生本部運営委員会 委員
  • 2015年03月 - 現在   北海道大学   化学物質等管理委員会 副委員長
  • 2013年06月 - 2015年03月   北海道大学   化学物質等管理委員会 委員
  • 2014年06月 - 2014年12月   室蘭工業大学   爆発事故調査委員会 委員


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