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Last Updated :2024/07/25

研究者情報

マスター

アカウント（マスター）

  • 氏名

    三井　信幸(ミツイ　ノブユキ), ミツイ　ノブユキ

所属（マスター）

  • 保健センター

所属（マスター）

  • 保健センター

独自項目

syllabus

  • 2021, 応用社会行動科学, Advanced Social and behavioral Sciences, 修士課程, 医学院, 「精神医学」、「気分障害」、「認知症」、「統合失調症」、「神経症」、「メンタルヘルス」「自殺」「精神保健行政」「評価尺度」 Psychiarty, mood disorder, dementia, schizophrenia, neurosis, mental health, suicide, mental health servic, evaluation scale
  • 2021, 基本医学研究, Master's Thesis Research in Medical Sciences, 修士課程, 医学院, 「精神医学」、「精神病理学」、「分子遺伝学」、「精神行動薬理学」、「神経画像学」、「神経生理学」 Psychiarty, psychopathology, molecular genetics, behavioral neuropsychopharmacology, neuroimaging, neurophysiology
  • 2021, 基本医学総論, Basic Principles of Medicine, 修士課程, 医学院, 「統合失調症」、「気分障害」、「不安障害」、「向精神薬」、「病態モデル」 schizophrenia, mood disorder, anxiety disorder, psychotropic drugs, models for psychiatric disease
  • 2021, 医学総論, Principles of Medicine, 博士後期課程, 医学院, 「精神疾患」、「向精神薬」、「機能画像」、「脳磁図」、「心理社会的治療法」 psychiatric disease, psychotrophic drugs, functional imaging, magnetic encephalography, psychosocial treatment
  • 2021, 基盤医学研究, Dissertation Research in Medical Sciences, 博士後期課程, 医学院, 「精神医学」、「精神病理学」、「分子遺伝学」、「精神行動薬理学」、「神経画像学」、「神経生理学」 Psychiarty, psychopathology, molecular genetics, behavioral neuropsychopharmacology, neuroimaging, neurophysiology
  • 2021, 臨床医学研究, Dissertation Research in Clinical Medicine, 博士後期課程, 医学院, 「精神疾患」、「向精神薬」、「機能画像」、「脳磁図」、「心理社会的治療法」 psychiatric disease, psychotrophic drugs, functional imaging, magnetic encephalography, psychosocial treatment

researchmap

プロフィール情報

所属

  • 北海道大学保健センター, 講師, 学校医

学位

  • 博士（医学）（北海道大学）

プロフィール情報

  • プロフィール

    臨床精神病理グループに所属し、様々な精神疾患の治療に従事しています。また、気分障害および自殺関連事象とその背景にあるパーソナリティとの関連を主に研究しています。

  • 姓

    三井, ミツイ

  • 名

    信幸, ノブユキ

  • ID各種

    201701010153236816

所属

  • 北海道大学保健センター, 講師, 学校医

業績リスト

研究キーワード

  • 社交不安症   摂食障害   性格特性   気質   パーソナリティ   自殺予防   気分障害   

研究分野

  • ライフサイエンス / 精神神経科学

学歴

  • 2009年04月 - 2013年03月   北海道大学   大学院医学研究科
  • 1997年04月 - 2003年03月   北海道大学   医学部   医学科

論文

  • クロザピン誘発発作に対する抗痙攣薬の使用 統合失調症患者における後ろ向き研究(Use of Anti-Seizure Medications for Clozapine-Induced Seizures: A Retrospective Study in Patients with Schizophrenia)
    堀之内 徹, 中村 悠一, 石川 修平, 橋本 直樹, 成田 尚, 三井 信幸, 賀古 勇輝, 久住 一郎
    てんかん研究 41 2 319 - 319 2023年09月
  • Satoshi Asakura, Naoki Yoshinaga, Hisashi Yamada, Yutaka Fujii, Nobuyuki Mitsui, Yoshihiro Kanai, Takeshi Inoue, Eiji Shimizu
    Neuropsychopharmacology Reports 43 3 288 - 309 2023年09月 [査読有り][通常論文]
  • Yutaka Fujii, Satoshi Asakura, Nguyen Tan Dat, Keisuke Takanobu, Shinya Watanabe, Kuniyoshi Toyoshima, Nobuyuki Mitsui, Atsuhito Toyomaki, Naoki Hashimoto, Yuki Kako, Ichiro Kusumi
    Asian journal of psychiatry 75 103215 - 103215 2022年09月
  • Nobuyuki Mitsui, Yutaka Fujii, Satoshi Asakura, Hissei Imai, Hisashi Yamada, Naoki Yoshinaga, Yoshihiro Kanai, Takeshi Inoue, Eiji Shimizu
    Neuropsychopharmacology Reports 2022年07月18日
  • Nguyen Tan Dat, Nobuyuki Mitsui, Satoshi Asakura, Keisuke Takanobu, Yutaka Fujii, Kuniyoshi Toyoshima, Yuki Kako, Ichiro Kusumi
    Frontiers in psychiatry 13 925423 - 925423 2022年 
    Suicide is a serious social issue and is often treated using psychological interventions. The current systematic review and meta-analysis aimed to investigate the effectiveness of self-esteem-related interventions on suicidal behaviors. A systematic literature search for randomized controlled trials (RCTs) including a self-esteem component was conducted on 29 May 2021 and updated on 4 April 2022. In total, 12 studies were included in the systematic review and five studies were included in the meta-analysis. Small effect sizes were found for suicidal ideation at post intervention [g = -0.24, 95% CI (-0.48, 0.00)] and a 3-month follow-up [g = -0.36, 95% CI (-0.62, -0.11)]. However, these results should be interpreted cautiously due to the limited number of included studies and varied sample population. In conclusion, the current review suggests that future intervention studies should incorporate self-esteem enhancement in the treatment of suicidal behaviors, especially for suicidal ideation. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=250882.
  • Nguyen Tan Dat, Nobuyuki Mitsui, Satoshi Asakura, Shinya Watanabe, Keisuke Takanobu, Yutaka Fujii, Kuniyoshi Toyoshima, Yuki Kako, Ichiro Kusumi
    Journal of Affective Disorders Reports 6 100192 - 100192 2021年12月
  • Yutaka Fujii, Satoshi Asakura, Keisuke Takanobu, Shinya Watanabe, Kuniyoshi Toyoshima, Nobuyuki Mitsui, Yuki Kako, Satoshi Hashino, Ichiro Kusumi
    Psychiatry and clinical neurosciences 75 9 294 - 295 2021年09月
  • Keisuke Takanobu, Daisuke Okazaki, Shinya Watanabe, Nobuyuki Mitsui, Teruaki Tanaka
    Neuropsychopharmacology reports 2021年06月24日 
    AIMS: We explored the use of pulverized medication as a new method to prevent intentional drug overdose. METHODS: This case study presents data obtained from the medical records of two female patients, aged 19 and 27 years, who presented with schizophrenia and neurodevelopmental disorder, respectively. Both patients provided written informed consent. Medication was administered to the two patients in powdered form, as opposed to in tablet form, in an attempt to prevent intentional drug overdose. RESULTS: This administration method successfully prevented intentional drug overdose for 3 and 5 years in each case, respectively. However, case-control or prospective cohort studies are needed to rule out biases, including cognitive bias. CONCLUSION: Pulverizing medication is a simple and effective means of preventing intentional drug overdose by restricting access to the means of suicide, regardless of the type of mental disorder.
  • 銅欠乏により汎血球減少をきたした摂食障害の1例
    岩渕 賢嗣, 藤井 泰, 渡辺 晋也, 豊島 邦義, 三井 信幸, 賀古 勇輝, 久住 一郎
    精神神経学雑誌 123 5 296 - 296 (公社)日本精神神経学会 2021年05月
  • Naoki Hashimoto, Hiroko Takeda, Yutaka Fujii, Yuriko Suzuki, Takahiro A. Kato, Daisuke Fujisawa, Kumi Aoyama-Uehara, Kotaro Otsuka, Nobuyuki Mitsui, Satoshi Asakura, Ichiro Kusumi
    Asian Journal of Psychiatry 102661 - 102661 2021年04月
  • Shinya Watanabe, Nobuyuki Mitsui, Satoshi Asakura, Kuniyoshi Toyoshima, Keisuke Takanobu, Yutaka Fujii, Yuki Kako, Ichiro Kusumi
    PloS one 16 9 e0257793  2021年 
    BACKGROUND: Social anxiety disorder (SAD) develops in the early teens and is a common disorder among university students. Understanding the predictive factors of SAD comorbid with major depressive episode (MDE) is important for student mental health care. The aim of this study was to identify the personality traits that predict SAD with MDE by analyzing longitudinal data of Japanese university students. METHODS: In this retrospective study, Japanese university students who visited the health care center of Hokkaido University for the first time were divided into the following four groups: "Control" (n = 43), "MDE" (n = 16), "SAD" (n = 28), and "SAD with MDE" (n = 61) based on the Patient Health Questionnaire-9 (PHQ-9), the Liebowitz Social Anxiety Scale, and core anxiety symptoms for SAD in the Mini International Neuropsychiatric Interview during screening. Predictors for SAD with MDE were identified by a four-group comparison of the Temperament and Character Inventory and PHQ-9 data previously obtained at the enrollment using analysis of variance and post-hoc tests. RESULTS: Upon comparing the four groups using analysis of variance, there were significant differences in the baseline PHQ-9 summary score, Harm-Avoidance (HA), and Self-Directedness (SD). According to results of the post-hoc test, all three showed a significant difference between the "Control" and "SAD with MDE." Furthermore, there was a significant difference in HA scores between "SAD" and "Control." In all the groups, the mean time from enrollment to the first visit to the center was >2 years. CONCLUSION: A higher HA score at baseline is a predictor of SAD with or without MDE. Higher PHQ-9 summary and lower SD scores at baseline are predictive factors of SAD with MDE.
  • Keisuke Takanobu, Nobuyuki Mitsui, Shinya Watanabe, Kuniyoshi Toyoshima, Yutaka Fujii, Yuki Kako, Satoshi Asakura, Ichiro Kusumi
    PloS one 16 5 e0251503  2021年 
    AIM: To enable early identification of university students at high risk for suicide, we examined personality as a predictive factor for major depressive episodes and suicide-related ideation. METHODS: From 2011 to 2013, we administered the Patient Health Questionnaire-9 (PHQ-9) and the Temperament and Character Inventory (TCI) to 1,997 university students at enrollment (T1). We previously conducted a study using the same data set; this is a re-analysis of the dataset. To prevent contamination of data, participants diagnosed with a depressive episode were excluded at T1. Three years after enrollment (T2), we re-administered the PHQ-9 to the same students. We statistically compared TCI scores at T1 among depressive episode groups and suicide-related ideation groups. Two-way ANOVA and Cochran-Armitage trend tests were used to analyze the relationships between personality traits, depressive episodes, and suicide-related ideation. RESULTS: The PHQ-9 summary scores at baseline (T1) were 3.0 (±2.7), with female students scoring 4.6 (±2.9) and male students 2.9 (±2.6, p = 0.025). The major depressive episode group at T2 had lower self-directedness (SD) scores at T1 than the non-depressive episode control group. The suicide-related ideation (SI) group at T2 also had higher harm avoidance (HA), lower SD, and lower cooperativeness (C) scores than the non-SI group at T1. The Cochran-Armitage trend tests revealed significant associations between character configurations composed of SD and C, and both depressive episodes at T2 and SI at T2. CONCLUSION: The temperament feature of high HA at baseline and character configurations of low SD and low C at baseline are the most contributory predictors for the novel development of depressive episodes and SI among Japanese university students.
  • Akiko Murakoshi, Nobuyuki Mitsui, Jiro Masuya, Yota Fujimura, Shinji Higashi, Ichiro Kusumi, Takeshi Inoue
    BioPsychoSocial Medicine 14 1 2020年12月 
    Abstract Background Previous studies reported that subjective well-being in adulthood correlates with perceived parental bonding in childhood as well as personality traits. However, whether personality traits mediate the effect of perceived parental bonding on well-being or not has not been reported to date. In this study, we hypothesized that ‘parental care and overprotection’ in childhood affect ‘well-being’ in adulthood through various ‘personality traits’, and analyzed this using structural equation modeling. Methods A total of 402 adult volunteers from the community provided responses to the following questionnaires: 1) Parental Bonding Instrument, 2) Temperament and Character Inventory, and 3) The Subjective Well-being Inventory. Two structural equation models were designed and the maximum likelihood estimation method was used for covariance structure analysis. Results Parental care in childhood directly increased well-being in adulthood and indirectly increased it through personality traits (harm avoidance, reward dependence, and self-directedness). Parental overprotection in childhood had no direct effect on well-being in adulthood but decreased well-being in adulthood indirectly through personality traits (harm avoidance, reward dependence, and self-directedness) and increased it through one personality trait (self-transcendence). Conclusions This study showed that the influences of perceived parental bonding on well-being in adulthood are mediated by self-directedness, harm avoidance, reward dependence, and self-transcendence among the seven personality dimensions evaluated by the Temperament and Character Inventory.
  • 双極性障害の症状寛解期における主観的認知機能、服薬、および服薬の効果の自覚
    豊島 邦義, 豊巻 敦人, 高信 径介, 渡辺 晋也, 藤井 泰, 三井 信幸, 賀古 勇輝, 朝倉 聡, 久住 一郎
    総合病院精神医学 32 Suppl. S - 159 (一社)日本総合病院精神医学会 2020年11月
  • 半夏厚朴湯が心理的葛藤の処理に寄与したうつ病の一例
    豊島 邦義, 高信 径介, 渡辺 晋也, 藤井 泰, 三井 信幸, 賀古 勇輝, 朝倉 聡, 久住 一郎
    総合病院精神医学 32 Suppl. S - 159 (一社)日本総合病院精神医学会 2020年11月
  • 双極性障害の症状寛解期における主観的認知機能と社会機能との関連について
    豊島 邦義, 豊巻 敦人, 高信 径介, 渡辺 晋也, 三井 信幸, 賀古 勇輝, 朝倉 聡, 久住 一郎
    精神神経学雑誌 2020特別号 S290 - S290 (公社)日本精神神経学会 2020年09月
  • 不安症・強迫症の診療ガイドライン 社交不安症の診療ガイドライン
    朝倉 聡, 山田 恒, 藤井 泰, 三井 信幸, 吉永 尚紀, 金井 嘉宏
    精神神経学雑誌 2020特別号 S363 - S363 (公社)日本精神神経学会 2020年09月
  • 双極性障害の症状寛解期における主観的認知機能とQOLに関する検討
    豊島 邦義, 豊巻 敦人, 高信 径介, 渡辺 晋也, 藤井 泰, 三井 信幸, 賀古 勇輝, 朝倉 聡, 久住 一郎
    日本神経精神薬理学会年会・日本生物学的精神医学会年会・日本精神薬学会総会・学術集会合同年会プログラム・抄録集 50回・42回・4回 196 - 196 日本神経精神薬理学会・日本生物学的精神医学会・日本精神薬学会 2020年08月
  • 双極性障害の症状寛解期における主観的認知機能と病識に関する検討
    豊島 邦義, 豊巻 敦人, 高信 径介, 渡辺 晋也, 藤井 泰, 三井 信幸, 賀古 勇輝, 朝倉 聡, 久住 一郎
    日本神経精神薬理学会年会・日本生物学的精神医学会年会・日本精神薬学会総会・学術集会合同年会プログラム・抄録集 50回・42回・4回 205 - 205 日本神経精神薬理学会・日本生物学的精神医学会・日本精神薬学会 2020年08月
  • 双極性障害の症状寛解期における主観的認知機能と事象関連電位に関する検討
    豊島 邦義, 宮崎 茜, 豊巻 敦人, 高信 径介, 渡辺 晋也, 藤井 泰, 三井 信幸, 賀古 勇輝, 朝倉 聡, 久住 一郎
    日本神経精神薬理学会年会・日本生物学的精神医学会年会・日本精神薬学会総会・学術集会合同年会プログラム・抄録集 50回・42回・4回 213 - 213 日本神経精神薬理学会・日本生物学的精神医学会・日本精神薬学会 2020年08月
  • 神経性やせ症に先天性プロテインS欠損症が合併した1例
    菱山 真広, 三井 信幸, 渡辺 晋也, 豊島 邦義, 賀古 勇輝, 久住 一郎, 杉田 純一
    精神神経学雑誌 122 5 394 - 394 (公社)日本精神神経学会 2020年05月
  • 学童期に低身長・低体重で発症した出産恐怖の1例
    小野 鉄舟, 三井 信幸, 渡辺 晋也, 豊島 邦義, 賀古 勇輝, 久住 一郎
    精神神経学雑誌 122 5 395 - 395 (公社)日本精神神経学会 2020年05月
  • 北海道における触法精神障害者医療の現状と展望
    高信 径介, 三井 信幸, 賀古 勇輝, 久住 一郎
    司法精神医学 15 1 89 - 89 日本司法精神医学会 2020年03月
  • 長期間にわたる全生活史健忘からの自然回復 右内側側頭葉の血流回復が確認された1例
    三井 信幸, 大柳 有加, 賀古 勇輝, 久住 一郎
    精神神経学雑誌 122 2 168 - 168 (公社)日本精神神経学会 2020年02月
  • Nobuyuki Mitsui, Yuka Oyanagi, Yuki Kako, Ichiro Kusumi
    BMJ case reports 12 12 2019年12月11日 [査読有り][通常論文]
     
    A 40-year-old man presented with generalised dissociative amnesia. At 2 weeks after onset, N-isopropyl-[123I] p-iodoamphetamine-single-photon emission CT imaging of the brain revealed hypoperfusion in the right medial temporal area. Organic brain damage was ruled out. His inability to recall information was attributed to psychological stress related to his employment. Consistent with this diagnosis, his generalised dissociative amnesia lasted 6 years and 10 months; however, he recovered from amnesia naturally on starting a new job. Perfusion of his right medial temporal area also returned to normal levels. Longitudinal reports for generalised dissociative amnesia with natural recovery are exceedingly rare. It is important to confirm whether dissociative amnesia and cerebral blood flow recover in parallel, even in cases where dissociative amnesia is long-lasting.
  • 不安症・強迫症の診療ガイドライン 社交不安症の診療ガイドライン
    朝倉 聡, 山田 恒, 藤井 泰, 三井 信幸, 吉永 尚紀, 金井 嘉宏
    日本臨床精神神経薬理学会・日本神経精神薬理学会合同年会プログラム・抄録集 29回・49回 45 - 45 日本臨床精神神経薬理学会・日本神経精神薬理学会 2019年10月
  • 胃切除後のダンピング症候群を合併し、病態が複雑化した神経性やせ症の一例
    黒鳥 偉作, 三井 信幸, 渡辺 晋也, 賀古 勇輝, 久住 一郎
    精神神経学雑誌 2019特別号 S423 - S423 (公社)日本精神神経学会 2019年06月
  • 医学的に不安定な摂食障害患者に対する皮下埋め込み型中心静脈ポートの有用性について
    黒鳥 偉作, 三井 信幸, 曽山 武士, 渡辺 晋也, 賀古 勇輝, 久住 一郎
    精神神経学雑誌 2019特別号 S428 - S428 (公社)日本精神神経学会 2019年06月
  • 不安症・強迫症の診療ガイドライン 社交不安症の診療ガイドライン
    朝倉 聡, 山田 恒, 藤井 泰, 三井 信幸, 吉永 尚紀, 金井 嘉宏
    精神神経学雑誌 2019特別号 S362 - S362 (公社)日本精神神経学会 2019年06月
  • 高信 径介, 渡辺 晋也, 三井 信幸, 賀古 勇輝, 朝倉 聡, 久住 一郎
    臨床精神薬理 22 3 285 - 292 (株)星和書店 2019年03月 
    自殺企図時には患者が過量服薬をしている例が多く、本邦の救命センターで受け入れる自殺企図患者の半数近くが過量服薬をしていたこと、過量服薬の反復企図例が多いことが繰り返し報告されており、また過量服薬は自殺完遂の強力なリスク因子である。本稿では既報の研究報告の網羅的な文献レビューを行い、主に本邦において過量服薬の予防介入のためにこれまでに試行されてきた対処法を概観し、国内外の研究報告の結果を交え、その有効性と限界について考察した。結果、過量服薬後の入院中の精神医学的治療介入、入院後12ヵ月のフォローアップ型の心理社会的介入、市販薬の法規制については量的なエビデンスが確認された。そのほかにも背景因子を考慮すると、従来推奨されている一般的な精神医学的治療、心理社会的介入、過量服薬の手段へのアクセスの制限、ゲートキーパーの教育研修による予防効果には期待できると考えられた。(著者抄録)
  • Ichiro Kusumi, Yuki Arai, Ryo Okubo, Minoru Honda, YasuhiroMatsuda, Yukihiko Matsuda, Akihiko Tochigi, Yoshiteru Takekita, Hiroyoshi Yamanaka, Keiichi Uemura, Koichi Ito, Kiyoshi Tsuchiya, Jun Yamada, Bunta Yoshimura, Nobuyuki Mitsui, Sigehiro Matsubara, Takayuki Segawa, Nobuyuki Nishi, Yasufumi Sugawara, Yuki Kako, Ikuta Shinkawa, Kaoru Shinohara, Akiko Konishi, Junichi Iga, Naoki Hashimoto, Shinsaku Inomata, Noriko Tsukamoto, Hiroto Ito, Yoichi M. Ito, Norihiro Sato
    BJPsych Open 4 6 454 - 460 2018年11月 [査読有り][通常論文]
     
    Background: Patients with schizophrenia or bipolar disorder have a high risk of developing type 2 diabetes. Aims: To identify predictive factors for hyperglycaemic progression in individuals with schizophrenia or bipolar disorder and to determine whether hyperglycaemic progression rates differ among antipsychotics in regular clinical practice. Method: We recruited 1166 patients who initially had normal or prediabetic glucose levels for a nationwide, multisite, l-year prospective cohort study to determine predictive factors for hyperglycaemic progression. We also examined whether hyperglycaemic progression varied among patients receiving monotherapy with the six most frequently used antipsychotics. Results: High baseline serum triglycerides and coexisting hypertension significantly predicted hyperglycaemic progression. The six most frequently used antipsychotics did not significantly differ in their associated hyperglycaemic progression rates over the 1-year observation period. Conclusions: Clinicians should carefully evaluate baseline serum triglycerides and coexisting hypertension and perform strict longitudinal monitoring irrespective of the antipsychotic used. Declaration of interest: The authors report no financial or other relationship that is relevant to the subject of this article. Relevant financial activities outside the submitted work are as follows. I.K. has received honoraria from Astellas, Chugai Pharmaceutical, Daiichi Sankyo, Dainippon Sumitomo Pharma, Eisai, Eli Lilly, Janssen Pharmaceutical, Kyowa Hakko Kirin, Meiji Seika Pharma, MSD, Nippon Chemiphar, Novartis Pharma, Ono Pharmaceutical, Otsuka Pharmaceutical, Pfizer, Tanabe Mitsubishi Pharma, Shionogi and Yoshitomiyakuhin; has received research/grant support from AbbVie GK, Asahi Kasei Pharma, Astellas, Boehringer Ingelheim, Chugai Pharmaceutical, Daiichi Sankyo, Dainippon Sumitomo Pharma, Eisai, Eli Lilly, GlaxoSmithKline, Kyowa Hakko Kirin, Meiji Seika Pharma, MSD, Novartis Pharma, Ono Pharmaceutical, Otsuka Pharmaceutical, Pfizer, Takeda Pharmaceutical, Tanabe Mitsubishi Pharma, Shionogi and Yoshitomiyakuhin; and is a member of the advisory boards of Dainippon Sumitomo Pharma and Tanabe Mitsubishi Pharma. Y.T. has received speaker's honoraria from Dainippon-Sumitomo Pharma, Otsuka, Meiji-Seika Pharma, Janssen Pharmaceutical, Daiichi-Sankyo Company, UCB Japan and Ono Pharmaceutical. K.U. has received honoraria from Dainippon Sumitomo Pharma, Eisai, Eli Lilly, Janssen Pharmaceutical, Kyowa Hakko Kirin, Meiji Seika Pharma, MSD, Takeda Pharmaceutical, Hisamitsu Pharmaceutical, Otsuka Pharmaceutical, Pfizer, Tanabe Mitsubishi Pharma, Shionogi and Yoshitomiyakuhin. B.Y. has received speaker's honoraria from Otsuka Pharmaceutical and Janssen Pharmaceutical. J. I. has received honoraria from Dainippon Sumitomo Pharma, Eli Lilly, Janssen Pharmaceutical, Meiji Seika Pharma, MSD, Novartis Pharma, Otsuka Pharmaceutical and Mochida Pharma.
  • Mitsui N, Asakura S, Takanobu K, Watanabe S, Toyoshima K, Kako Y, Ito YM, Kusumi I
    PloS one 13 7 e0201047  2018年 [査読有り][通常論文]
     
    BACKGROUND: Suicide has been a leading cause of death among young adult populations in Japan. The aim of this study was to predict major depressive episodes (MDEs) and suicide-related ideation among university students using the Patient Health Questionnaire-9 (PHQ-9) and the Temperament and Character Inventory (TCI). METHODS: The subjects were 2194 university students who completed the PHQ-9 and TCI in the 1st year (T1) and the PHQ-9 in the 4th year (T2) of university. Multiple logistic regression analysis was performed to predict MDEs and suicide-related ideation at T2. Moreover, recursive partitioning analyses were conducted to reveal the future risk of MDEs and suicide-related ideation. RESULTS: The multiple logistic regression analyses of MDEs and suicide-related ideation at T2 revealed that depressive episodes, suicide-related ideation, and low self-directedness(SD) scores at T1 were significant predictors. The area under the curve of the model for MDEs was 0.858 and that for suicide-related ideation was 0.741. The recursive partitioning analyses revealed that a PHQ-9 summary score ≥15 at T1 predicted a high risk of MDEs at T2 and that both a PHQ-9 summary score ≥5 and a PHQ-9 #9 score ≥1 predicted a high risk of suicide-related ideation at T2. CONCLUSIONS: MDEs, suicide-related ideation, and low SD scores are significant predictors of future MDEs and suicide-related ideation.
  • Kuniyoshi Toyoshima, Yutaka Fujii, Nobuyuki Mitsui, Yuki Kako, Satoshi Asakura, Anabel Martinez-Aran, Eduard Vieta, Ichiro Kusumi
    PSYCHIATRY RESEARCH 254 85 - 89 2017年08月 [査読有り][通常論文]
     
    In Japan, there are currently no reliable rating scales for the evaluation of subjective cognitive impairment in patients with bipolar disorder. We studied the relationship between the Japanese version of the Cognitive Complaints in Bipolar Disorder Rating Assessment (COBRA) and objective cognitive assessments in patients with bipolar disorder. We further assessed the reliability and validity of the COBRA. Forty-one patients, aged 16-64, in a remission period of bipolar disorder were recruited from Hokkaido University Hospital in Sapporo, Japan. The COBRA (Japanese version) and Frankfurt Complaint Questionnaire (FCQ), the gold standard in subjective cognitive assessment, were administered. A battery of neuropsychological tests was employed to measure objective cognitive impairment. Correlations among the COBRA, FCQ, and neuropsychological tests were determined using Spearman's correlation coefficient. The Japanese version of the COBRA had high internal consistency, good retest reliability, and concurrent validity as indicated by a strong correlation with the FCQ. A significant correlation was also observed between the COBRA and objective cognitive measurements of processing speed. These findings are the first to demonstrate that the Japanese version of the COBRA may be clinically useful as a subjective cognitive impairment rating scale in Japanese patients with bipolar disorder.
  • Nobuyuki Mitsui, Yukiei Nakai, Takeshi Inoue, Niki Udo, Kan Kitagawa, Yumi Wakatsuki, Rie Kameyama, Atsuhito Toyomaki, Yoichi M. Ito, Yuji Kitaichi, Shin Nakagawa, Ichiro Kusumi
    PLOS ONE 12 6 e0179952  2017年06月 [査読有り][通常論文]
     
    Background Suicide rates are vastly higher in Japan than in many other countries, although the associations between affective temperaments and suicide-related ideations in the general adult population remain unclear. Therefore, we aimed to elucidate these associations in the present study. Methods We analyzed data from 638 Japanese volunteers who completed both the Patient Health Questionnaire (PHQ-9) and the Temperament Evaluation of the Memphis, Pisa, Paris, and San Diego Auto-questionnaire (TEMPS-A). Participants were then divided into three groups based on PHQ-9 summary scores and responses to the suicide-related ideation item: non-depressive control group (NC; N = 469), depressive symptoms without suicide-related ideations group (non-SI; N = 135), and depressive symptoms with suicide-related ideations group (SI; N = 34). The depressive symptoms were defined for PHQ-9 summary scores >= 5, and the suicide-related ideations were defined for PHQ-9 #9 score >= 1. We then compared TEMPS-A scores among the groups using Kruskal-Wallis tests. Then the 95% confidence intervals of differences in TEMPS-A subscale scores between the NC and non-SI groups, or between NC and SI groups, were calculated. Results Participants of the SI group exhibited significantly higher scores on the depressive, irritable, and anxious temperament subscales than those of the non-SI group. Similarly, women of the SI group exhibited significantly higher scores of the depressive and irritable temperament subscales than women of the non-SI group, while men of the SI group exhibited significantly higher depressive temperament scores than those of the non-SI group. Among all participants and only men, cyclothymic subscale scores were higher in those of the SI group than the non-SI group (not significant), although the 95% confidence intervals did not overlap. Limitations The cross-sectional study design was the main limitation. Conclusions Depressive, irritable, and anxious temperaments are significant risk factors for suicide-related ideations in the Japanese general adult population. Furthermore, irritable temperament in women and depressive temperament in men are associated with suicide-related ideations.
  • Nobuyuki Mitsui, Satoshi Asakura, Yusuke Shimizu, Yutaka Fujii, Yuki Kako, Teruaki Tanaka, Koji Oba, Takeshi Inoue, Ichiro Kusumi
    Comprehensive Psychiatry 62 218  2015年10月01日 [査読有り][通常論文]
  • Hiroyuki Toda, Takeshi Inoue, Tomoya Tsunoda, Yukiei Nakai, Masaaki Tanichi, Teppei Tanaka, Naoki Hashimoto, Yasuya Nakato, Shin Nakagawa, Yuji Kitaichi, Nobuyuki Mitsui, Shuken Boku, Hajime Tanabe, Masashi Nibuya, Aihide Yoshino, Ichiro Kusumi
    Neuropsychiatric disease and treatment 11 2079 - 90 2015年 [査読有り][通常論文]
     
    BACKGROUND: Previous studies have shown the interaction between heredity and childhood stress or life events on the pathogenesis of a major depressive disorder (MDD). In this study, we tested our hypothesis that childhood abuse, affective temperaments, and adult stressful life events interact and influence the diagnosis of MDD. PATIENTS AND METHODS: A total of 170 healthy controls and 98 MDD patients were studied using the following self-administered questionnaire surveys: the Patient Health Questionnaire-9 (PHQ-9), the Life Experiences Survey, the Temperament Evaluation of the Memphis, Pisa, Paris, and San Diego Autoquestionnaire, and the Child Abuse and Trauma Scale (CATS). The data were analyzed with univariate analysis, multivariable analysis, and structural equation modeling. RESULTS: The neglect scores of the CATS indirectly predicted the diagnosis of MDD through cyclothymic and anxious temperament scores of the Temperament Evaluation of the Memphis, Pisa, Paris, and San Diego Autoquestionnaire in the structural equation modeling. Two temperaments - cyclothymic and anxious - directly predicted the diagnosis of MDD. The validity of this result was supported by the results of the stepwise multivariate logistic regression analysis as follows: three factors - neglect, cyclothymic, and anxious temperaments - were significant predictors of MDD. Neglect and the total CATS scores were also predictors of remission vs treatment-resistance in MDD patients independently of depressive symptoms. LIMITATIONS: The sample size was small for the comparison between the remission and treatment-resistant groups in MDD patients in multivariable analysis. CONCLUSION: This study suggests that childhood abuse, especially neglect, indirectly predicted the diagnosis of MDD through increased affective temperaments. The important role as a mediator of affective temperaments in the effect of childhood abuse on MDD was suggested.
  • Hiroyuki Toda, Takeshi Inoue, Tomoya Tsunoda, Yukiei Nakai, Masaaki Tanichi, Teppei Tanaka, Naoki Hashimoto, Yasuya Nakato, Shin Nakagawa, Yuji Kitaichi, Nobuyuki Mitsui, Shuken Boku, Hajime Tanabe, Masashi Nibuya, Aihide Yoshino, Ichiro Kusumi
    NEUROPSYCHIATRIC DISEASE AND TREATMENT 11 2079 - 2090 2015年 [査読有り][通常論文]
     
    Background: Previous studies have shown the interaction between heredity and childhood stress or life events on the pathogenesis of a major depressive disorder (MDD). In this study, we tested our hypothesis that childhood abuse, affective temperaments, and adult stressful life events interact and influence the diagnosis of MDD.Patients and methods: A total of 170 healthy controls and 98 MDD patients were studied using the following self-administered questionnaire surveys: the Patient Health Questionnaire-9 (PHQ-9), the Life Experiences Survey, the Temperament Evaluation of the Memphis, Pisa, Paris, and San Diego Autoquestionnaire, and the Child Abuse and Trauma Scale (CATS). The data were analyzed with univariate analysis, multivariable analysis, and structural equation modeling.Results: The neglect scores of the CATS indirectly predicted the diagnosis of MDD through cyclothymic and anxious temperament scores of the Temperament Evaluation of the Memphis, Pisa, Paris, and San Diego Autoquestionnaire in the structural equation modeling. Two temperaments - cyclothymic and anxious - directly predicted the diagnosis of MDD. The validity of this result was supported by the results of the stepwise multivariate logistic regression analysis as follows: three factors - neglect, cyclothymic, and anxious temperaments - were significant predictors of MDD. Neglect and the total CATS scores were also predictors of remission vs treatment-resistance in MDD patients independently of depressive symptoms.Limitations: The sample size was small for the comparison between the remission and treatment-resistant groups in MDD patients in multivariable analysis.Conclusion: This study suggests that childhood abuse, especially neglect, indirectly predicted the diagnosis of MDD through increased affective temperaments. The important role as a mediator of affective temperaments in the effect of childhood abuse on MDD was suggested.
  • Yuki Kako, Koki Ito, Naoki Hashimoto, Kuniyoshi Toyoshima, Yusuke Shimizu, Nobuyuki Mitsui, Yutaka Fujii, Teruaki Tanaka, Ichiro Kusumi
    Neuropsychiatric Disease and Treatment 10 1415 - 1422 2014年07月29日 [査読有り][通常論文]
     
    Objectives: To examine the relationship between level of insight and various subjective experiences for patients with schizophrenia. Materials and methods:Seventy-four patients with schizophrenia who were discharged from our hospital were evaluated. The level of insight into their illness and various subjective experiences were evaluated at discharge. We used the Scale to Assess Unawareness of Mental Disorder (SUMD) for evaluation of insight. In addition, five different rating scales were used to evaluate subjective experiences: Subjective Experience of Deficits in Schizophrenia (SEDS), Subjective Well-being under Neuroleptic drug treatment Short form (SWNS), Schizophrenia Quality of Life Scale (SQLS), Beck Depression Inventory (BDI), and the Drug Attitude Inventory (DAI)-30. Results: The SWNS and the scores for awareness of mental disorder and awareness of the social consequences of mental disorder on SUMD showed a weak positive correlation. The DAI-30 showed a significant negative correlation with most general items on SUMD and a negative correlation between the subscale scores for the awareness and attribution of past symptoms. SEDS, SWNS, SQLS, and the BDI significantly correlated with the subscale scores for awareness of current symptoms on SUMD, and weakly correlated with the subscale scores for attribution of current negative symptoms. Conclusion: Awareness of subjective distress was related to awareness of having a mental disorder. Feeling subjective distress was related to awareness of current symptoms, as well as to the ability to attribute current negative symptoms to a mental disorder. Positive attitudes toward medication correlated with better general insight into the illness. © 2014 Kako et al.
  • Kako Y, Okubo R, Shimizu Y, Mitsui N, Tanaka T, Kusumi I
    Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica 116 10 813 - 824 2014年 [査読有り][通常論文]
     
    Over 10 years have passed since the Japanese term for "schizophrenia" was changed from "seishin-bunretsu-byo" to "togo-shiccho-sho" in 2002. An awareness survey targeting doctors suggested that notification of the diagnosis has been encouraged since the Japanese name for schizophrenia was changed. However, no heuristic surveys targeting patients themselves have clarified an increased notification rate, and no multicenter studies of the notification rates have been conducted in recent years. This study targeted schizophrenia patients and their attending physicians to investigate the status of notification of the diagnosis at five medical facilities in Hokkaido, Japan. Questionnaires were distributed to the attending physicians of a total of 869 patients; in addition, the patients themselves filled out questionnaires. Questionnaires were collected from 858 physicians, and valid responses were recovered from 529 patients. This study investigated the status of notification of the diagnosis and compared the attributes of patients who were notified (notified group) with those of patients who were not notified (un-notified group). The results of the survey of attending physicians regarding notification of the diagnosis of schizophrenia indicated that a total of 65.0% patients had been notified, with 63.1% of patients being notified that they had "togo-shiccho-sho" and 2.0% of patients being notified that they had "seishin-bunretsu-byo." Physicians were unsure whether patients had been notified in 18.4% of cases. On excluding these cases, the results indicated that over 79.6% of patients had been notified that they had either "togo-shiccho-sho" or "seishin-bunretsu-byo." The patient questionnaire results regarding patients' awareness of the name of their disease showed that 55.2% answered "togo-shiccho-sho," 3.2% answered "seishin-bunretsu-byo," 9.5% answered the name of another disease, 17.4% answered that they did not know the name of their disease, and 14.7% answered that they knew the name of their disease but did not include any specific details. On excluding these unspecified answers, 68.5% of patients were aware that they had either "togo-shiccho-sho" or "seishin-bunretsu-byo." Comparison of the notified with the un-notified group revealed that the period from treatment initiation in the notified group was shorter than that in the un-notified group, and the mean age of the notified group at the time of the survey was lower than that of the un-notified group. Furthermore, significantly more patients started treatment before 2002, when the Japanese name for schizophrenia was changed, in the un-notified group. The results of this study suggested that the change of the Japanese name of schizophrenia to "togo-shiccho-sho" and historical background resulted in more active notification of the diagnosis.
  • Nobuyuki Mitsui, Satoshi Asakura, Yusuke Shimizu, Yutaka Fujii, Atsuhito Toyomaki, Yuki Kako, Teruaki Tanaka, Nobuki Kitagawa, Takeshi Inoue, Ichiro Kusumi
    NEUROPSYCHIATRIC DISEASE AND TREATMENT 10 811 - 816 2014年 [査読有り][通常論文]
     
    Background: The suicide risk among young adults is related to multiple factors; therefore, it is difficult to predict and prevent suicidal behavior. Aim: We conducted the present study to reveal the most important factors relating to suicidal ideation in Japanese university students with major depressive episodes (MDEs) of major depressive disorder (MDD). Methods: The subjects were 30 Japanese university students who had MDEs of MDD, and were aged between 18 and 26 years old. They were divided into two groups - without suicide risk group (n= 15), and with suicide risk group (n= 15) - based on the results of the Mini - International Neuropsychiatric Interview. Additionally, healthy controls were recruited from the same population (n= 15). All subjects completed the self- assessment scales including the Beck Depression Inventory 2nd edition (BDI-II), the Beck Hopelessness Scale (BHS), Rosenberg's Self-Esteem Scale (RSES), and SF-36v2 (TM) (The Medical Outcomes Study 36-item short-form health survey version 2), and they were all administered a battery of neuropsychological tests. Results: The RSES score of the suicide risk group was significantly lower than the RSES score of the without suicide risk group, whereas the BDI-II score and the BHS score were not - significantly different between the two groups. The mean social functioning score on the SF-36v2 of the with suicide risk group was significantly lower than that of the without suicide risk group. Conclusion: The individual's self- esteem and social functioning may play an important role in suicide risk among young adults with MDEs of MDD.
  • Yuki Kako, Koki Ito, Naoki Hashimoto, Kuniyoshi Toyoshima, Yusuke Shimizu, Nobuyuki Mitsui, Yutaka Fujii, Teruaki Tanaka, Chiro Kusumi
    NEUROPSYCHIATRIC DISEASE AND TREATMENT 10 1415 - 1422 2014年 [査読有り][通常論文]
     
    Objectives: To examine the relationship between level of insight and various subjective experiences for patients with schizophrenia. Materials and methods: Seventy-four patients with schizophrenia who were discharged from our hospital were evaluated. The level of insight into their illness and various subjective experiences were evaluated at discharge. We used the Scale to Assess Unawareness of Mental Disorder (SUMD) for evaluation of insight. In addition, five different rating scales were used to evaluate subjective experiences: Subjective Experience of Deficits in Schizophrenia (SEDS), Subjective Well-being under Neuroleptic drug treatment Short form (SWNS), Schizophrenia Quality of Life Scale (SQLS), Beck Depression Inventory (BDI), and the Drug Attitude Inventory (DAI)-30. Results: The SWNS and the scores for awareness of mental disorder and awareness of the social consequences of mental disorder on SUMD showed a weak positive correlation. The DAI-30 showed a significant negative correlation with most general items on SUMD and a negative correlation between the subscale scores for the awareness and attribution of past symptoms. SEDS, SWNS, SQLS, and the BDI significantly correlated with the subscale scores for awareness of current symptoms on SUMD, and weakly correlated with the subscale scores for attribution of current negative symptoms. Conclusion: Awareness of subjective distress was related to awareness of having a mental disorder. Feeling subjective distress was related to awareness of current symptoms, as well as to the ability to attribute current negative symptoms to a mental disorder. Positive attitudes toward medication correlated with better general insight into the illness.
  • Mitsui N, Asakura S, Shimizu Y, Fujii Y, Toyomaki A, Kako Y, Tanaka T, Kitagawa N, Inoue T, Kusumi I
    Neuropsychiatric disease and treatment 10 811 - 816 2014年 [査読有り][通常論文]
  • Yusuke Shimizu, Nobuki Kitagawa, Nobuyuki Mitsui, Yutaka Fujii, Atsuhito Toyomaki, Naoki Hashimoto, Yuki Kako, Teruaki Tanaka, Satoshi Asakura, Ichiro Kusumi
    Psychiatry Research 210 3 913 - 918 2013年12月30日 [査読有り][通常論文]
     
    Quality of life (QOL) has been reported to be impaired in patients with major depressive disorder (MDD), even after remission according to symptom rating scales. Although a relationship between QOL and neurocognitive dysfunction has been reported during depressive episodes, little is known about this relationship in remitted MDD patients. The aim of the present study was to investigate the relationship between QOL and neurocognitive dysfunction in patients with remitted MDD while controlling for confounding factors. Forty-three remitted MDD patients were assessed with neuropsychological tests and QOL, which was measured by a short-form 36-item health survey. The neurocognitive performances of the patients were compared with those of 43 healthy controls. We next evaluated the relationships between neurocognitive impairments, clinical factors, and QOL. Remitted MDD patients had poorer neurocognitive performances than healthy controls for psychomotor speed, attention, and verbal memory. Residual depressive symptoms were strongly associated with QOL. Delayed verbal recall was associated with general health perceptions, which are part of the QOL assessment, even after the effects of the residual depressive symptoms were considered. The results may indicate that clinicians should try to detect neurocognitive dysfunctions that may interfere with QOL using neurocognitive assessments in their daily practice. © 2013 Elsevier Ireland Ltd.
  • Nobuyuki Mitsui, Satoshi Asakura, Yusuke Shimizu, Yutaka Fujii, Yuki Kako, Teruaki Tanaka, Koji Oba, Takeshi Inoue, Ichiro Kusumi
    Comprehensive psychiatry 54 8 1215 - 21 2013年11月 [査読有り][通常論文]
     
    OBJECTIVE: The aim of our study was to reveal the personality traits of individuals with major and other depressive episodes among the young adult population. Furthermore, character traits of individuals with ideas of suicide or self-harm were also investigated in this study. METHODS: The subjects of this study were 1421 university students who completed the Patient Health Questionnaire (PHQ-9) and the Temperament and Character Inventory (TCI). The subjects were divided into three separate groups: the major depressive episode group (N = 41), the other depressive episode group (N = 97), and the non-depressive controls (N = 1283). This separation was achieved using the PHQ-9 algorithm diagnosis. We compared the TCI scores using an analysis of variance. Moreover, the Cochran-Armitage trend test was used to determine the diagnosis, ideas of suicide or self-harm, and analysis of character profiles. RESULTS: The major depressive episode group had significantly higher HA (P < 0.001), lower RD (P < 0.001), lower SD (P < 0.001), and lower C (P < 0.001) scores than non-depressive controls. The other depressive episode group had significantly higher HA scores (P < 0.001) and lower SD scores (P < 0.001) than non-depressive controls. The Cochran-Armitage trend test revealed that the prevalence of depressive episodes decreased as the character profiles matured (χ(2)(trend) = 57.2, P < 0.0001). The same tendency was observed in individuals who had ideas of suicide or self-harm (χ(2)(trend) = 49.3, P < 0.0001). CONCLUSION: High HA and low SD scores were common personality traits among young adults with major depressive episodes. Furthermore, the immaturity of character profiles was clearly associated with depressive episodes and ideas of suicide or self-harm.
  • Yuji Kitaichi, Takeshi Inoue, Nobuyuki Mitsui, Shin Nakagawa, Rie Kameyama, Yoshiyuki Hayashishita, Tohru Shiga, Ichiro Kusumi, Tsukasa Koyama
    Neuropsychiatric Disease and Treatment 9 1591 - 1594 2013年10月16日 [査読有り][通常論文]
     
    We report a case in which selegiline, an irreversible monoamine oxidase B (MAO-B) inhibitor, greatly improved depressive symptoms in an adult with stage 5 treatment-resistant major depressive disorder. Four antidepressants and four augmentation therapies had previously been ineffective or intolerable, and electroconvulsive therapy had only a temporary effect. After 20 weeks of treatment with selegiline (10 mg/day), the patient's score on the 17-item Hamilton Depression Rating Scale (HDRS) had decreased from 19 to 4 points. [18F]-Fluorodeoxyglucose positron emission tomography (FDG-PET) showed increased glucose metabolism in the bilateral basal ganglia after initiating selegiline treatment blood dopamine levels were also increased after selegiline treatment. These results raise the possibility that selegiline enhances dopaminergic neural transmission in treatment-resistant depression, thus leading to an improvement in depressive symptoms. © 2013 Kitaichi et al.
  • Nobuyuki Mitsui, Satoshi Asakura, Takeshi Inoue, Yusuke Shimizu, Yutaka Fujii, Yuki Kako, Teruaki Tanaka, Nobuki Kitagawa, Ichiro Kusumi
    COMPREHENSIVE PSYCHIATRY 54 5 556 - 561 2013年07月 [査読有り][通常論文]
     
    Objective: The aims of this study were to investigate the personality traits of suicide completers using the Temperament and Character Inventory (TCI) scale. Methods: Newly enrolled students who enrolled at Hokkaido University in 1999-2002 and 2004-2007 completed the TCI. Among these students, twenty subjects (2 females and 18 males) later completed suicide. We compared the TCI scales of these subjects with those of 60 (6 females and 54 males) well-matched controls. The controls were matched for age, gender, university department and year of enrollment in the university. Because the number of females was too small, the statistical analyses for the TCI subscales and logistic regression analysis were performed only with the 18 males. Results: A univariate analysis of seven personality dimensions on the TCI revealed higher scores of harm avoidance (HA) in subjects with suicide completion (P=0.034). Analysis of the male subjects showed that suicide completers had higher scores for anticipatory worry (HA1 P=0.007) and fear of uncertainty (HA2, P=0.036) and lower scores for spiritual acceptance (ST3, P=0.038) than did the controls. A multivariate analysis, which was performed to adjust confounding factors, demonstrated significantly higher scores for HA1 among suicide completers (P=0.01, OR=1.32). Conclusions: These results suggest that higher HA scores may predict suicide completion. (C) 2013 Elsevier Inc. All rights reserved.
  • Yutaka Fujii, Nobuki Kitagawa, Yusuke Shimizu, Nobuyuki Mitsui, Atsuhito Toyomaki, Naoki Hashimoto, Yuki Kako, Teruaki Tanaka, Satoshi Asakura, Tsukasa Koyama, Ichiro Kusumi
    Neuroscience Letters 543 42 - 46 2013年05月24日 [査読有り][通常論文]
     
    To evaluate neurocognitive functions of patients with social anxiety disorder (SAD) without comorbidity using neuropsychological assessments and to investigate the relation between neurocognitive functions and clinical severity of SAD, this study assessed 30 SAD patients (10 female, 20 male) without comorbidity and 30 healthy subjects matched on gender, education level, and age. The neuropsychological assessment consisted of the Wisconsin card sorting test (WCST), the continuous performance test, the trail-making test, the word fluency test, and the auditory verbal learning test. On the WCST, patients showed lower performance than healthy controls did. The Liebowitz Social Anxiety Scale score correlated significantly with the numbers of perseverative errors of the WCST, although the State anxiety score of State-Trait Anxiety Inventory and the Beck Depression Inventory - Second Edition score showed no correlation with neuropsychological test scores. Results show that the executive functioning of patients with SAD was low and that the low functioning correlates with the SAD symptom severity. © 2013 Elsevier Ireland Ltd.

MISC

  • 藤井泰, 藤井泰, 朝倉聡, 朝倉聡, グエン タンダット, 高信径介, 豊島邦義, 三井信幸, 賀古勇輝, 橋野聡, 久住一郎 日本不安症学会学術大会プログラム・抄録集 15th 2023年
  • 社交不安症の診療ガイドライン
    清水 栄司, 井上 猛, 佐々木 司, 熊野 宏昭, 稲田 健, 松永 寿人, 塩入 俊樹, 朝倉 聡, 今井 必生, 竹島 望, 早坂 佑, 馬場 俊明, 山田 恒, 藤井 泰, 三井 信幸, 吉永 尚紀, 金井 嘉宏, 貝谷 久宣, 鈴木 伸一, 奥村 泰之, 有園 正俊, 生坂 政臣, 日本不安症学会, 日本神経精神薬理学会 不安症研究 13 (1) 53 -111 2021年11月
  • 社交不安症の診療ガイドライン
    清水 栄司, 井上 猛, 佐々木 司, 熊野 宏昭, 稲田 健, 松永 寿人, 塩入 俊樹, 朝倉 聡, 今井 必生, 竹島 望, 早坂 佑, 馬場 俊明, 朝倉 聡, 山田 恒, 藤井 泰, 三井 信幸, 吉永 尚紀, 金井 嘉宏, 貝谷 久宣, 鈴木 伸一, 奥村 泰之, 有園 正俊, 生坂 政臣, 日本不安症学会, 日本神経精神薬理学会 不安症研究 13 (1) 53 -111 2021年11月
  • 高信径介, 横浜愛, 渡辺晋也, 豊島邦義, 三井信幸, 三井信幸, 賀古勇輝, 朝倉聡, 朝倉聡, 久住一郎 日本自殺予防学会総会プログラム・抄録集 43rd 2019年
  • 岡 松彦, 板橋 彩, 森川 一史, 大宮 友貴, 梅津 弘樹, 三井 信幸 精神医学 60 (6) 681 -686 2018年06月 [査読無し][通常論文]
     
    ＜文献概要＞統合失調症の発症や経過においてエストロゲンは保護的に作用し,閉経などによりエストロゲンが低下すると症状が増悪することがある。症例は53歳女性,統合失調症。27歳時に幻覚妄想状態で発症し,37歳時より加療開始されたが,44歳時に服薬通院を自己中断した。約9年間の無治療期間の後に緊張病性興奮を呈し,当科入院後に亜昏迷状態に陥った。Olanzapineを開始して一度亜昏迷を脱したものの,以後約1か月ごとに緊張病症状を呈し1週間程度で自然軽快することを繰り返した。ホルモン補充療法を開始したところ緊張病症状は消褪し,約半年後にホルモン補充療法を終了したが寛解を維持した。統合失調症の緊張病症状に対するホルモン補充療法の有効性について考察を交えて報告する。
  • 金子 恭昌, 金子 真由美, 渡邊 智恵, 堀 利奈, 梅津 弘樹, 岡 松彦, 荒井 勇輝, 三井 信幸 精神医学 59 (12) 1129 -1134 2017年12月 [査読無し][通常論文]
     
    うつ病に対する行動活性化療法(behavioral activation;BA)の治療効果には数多くの報告がある。今回,我々は反復性うつ病性障害の30代男性にBAを導入した。些細な負荷から症状が再燃し,行動を起こすことに躊躇する傾向がみられたが,粘り強くBAを継続した。その結果,抑うつ症状が改善し,さらには自己効力感の向上も認められた。これらはBAの特徴であるACTIONモデルに基づいた行動から得られた成功体験や達成経験によるものと考えられる。BAの適応の1つに「自己効力感を高めたい時」がある。今後も抑うつ症状が遷延するうつ病に対するBAの適応や有効性についてさらなる知見の蓄積が期待される。(著者抄録)
  • 大学生のK-10およびPHQ-9に対する自尊感情および絶望感の影響について
    石原 可愛, 三井 信幸, 朝倉 聡, 武田 弘子, 川島 るい, 小西 優佳, 藤岡 大輔, 橋野 聡 全国大学保健管理研究集会プログラム・抄録集 55回 112 -112 2017年11月 [査読無し][通常論文]
  • 大学生の大うつ病エピソードおよび自殺念慮の予測に関する研究
    三井 信幸, 朝倉 聡, 豊島 邦義, 藤井 泰, 賀古 勇輝, 久住 一郎 日本うつ病学会総会・日本認知療法・認知行動療法学会プログラム・抄録集 14回・17回 266 -266 2017年07月 [査読無し][通常論文]
  • 袴田 里実, 三井 信幸, 前田 珠希, 豊島 邦義, 藤井 泰, 賀古 勇輝, 柳生 一自, 須山 聡, 斎藤 卓弥, 久住 一郎 心身医学 57 (6) 651 -651 2017年06月 [査読無し][通常論文]
  • 当院のうつ病に対するduloxetine、escitalopramの処方調査
    梅津 弘樹, 岡 松彦, 三井 信幸 精神神経学雑誌 118 (9) 714 -714 2016年09月 [査読無し][通常論文]
  • 地方公務員の気質-性格特性とうつ病エピソードの関連について
    三井 信幸, 岡 松彦, 梅津 弘樹 精神神経学雑誌 118 (9) 716 -716 2016年09月 [査読無し][通常論文]
  • 岡 松彦, 大宮 友貴, 梅津 弘樹, 荒井 勇輝, 三井 信幸 精神医学 58 (8) 701 -705 2016年08月 [査読無し][通常論文]
     
    SCAP(safety correction of antipsychotics poly-pharmacy and high-dose)法は,抗精神病薬の多剤大量療法の減薬方法として考案されたものである。症例は55歳男性,統合失調症。23歳時に幻覚妄想状態で発症し,入退院を繰り返すうちに入院が長期化し,処方が多剤大量となった。一時は合計chlorpromazine換算が最大4,865mg/日に及び,約20年かけて1,400mg/日まで減量されたが幻覚妄想や陰性症状が遷延した。Aripiprazole(APZ)への切り替えも過去に2度失敗していたが,今回SCAP法を用いてAPZ単剤へ集約し得た。SCAP法を用いた主剤変更について考察した。(著者抄録)
  • Ichiro Kusumi, Yuki Arai, Junichi Iga, Yasuhiro Matsuda, Nobuyuki Mitsui, Hiroyuki Muraoka, Kota Ohno, Ryo Okubo, Norihiro Sato, Takayuki Segawa, Kaoru Shinohara, Akihiko Tohigi, Keiichi Uemura, Hiroyoshi Yamanaka INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY 19 59 -59 2016年06月 [査読無し][通常論文]
  • 三井 信幸, 朝倉 聡, 清水 祐輔, 藤井 泰, 賀古 勇輝, 田中 輝明, 井上 猛, 久住 一郎 心身医学 56 (4) 383 -383 2016年04月 [査読無し][通常論文]
  • 2施設での後方視調査によるblonanserinの用法に関する検討
    岡 松彦, 大宮 友貴, 梅津 弘樹, 高信 径介, 渡辺 晋也, 小川 智生, 古堅 祐行, 岡崎 大介, 三井 信幸 精神神経学雑誌 118 (4) 258 -258 2016年04月 [査読無し][通常論文]
  • Nobuyuki Mitsui, Satoshi Asakura, Takeshi Inoue, Yusuke Shimizu, Yutaka Fujii, Yuki Kako, Teruaki Tanaka, Nobuki Kitagawa, Ichiro Kusumi COMPREHENSIVE PSYCHIATRY 60 168 -169 2015年07月 [査読無し][通常論文]
  • 礼文島における土砂災害後のこころの支援活動に関する報告
    三井 信幸, 荒井 勇輝, 岡 松彦 精神神経学雑誌 117 (6) 486 -486 2015年06月 [査読無し][通常論文]
  • Aripiprazoleにより著明な体重増加を来した症例の検討 ケースシリーズ
    岡 松彦, 大宮 友貴, 橋本 直樹, 荒井 勇輝, 三井 信幸 精神神経学雑誌 116 (12) 1040 -1040 2014年12月 [査読無し][通常論文]
  • 統合失調症患者の病名告知に関する多施設調査
    賀古 勇輝, 大久保 亮, 清水 祐輔, 三井 信幸, 田中 輝明, 久住 一郎 精神神経学雑誌 116 (10) 813 -824 2014年10月 [査読無し][通常論文]
     
    2002年に「精神分裂病」から「統合失調症」へと呼称が変更されてから10年以上が経過した.呼称変更後に病名告知が促進されていることは,医師に対する意識調査で示唆されているが,患者自身に対する実態調査では告知率の増加は明らかにされておらず,近年は多施設による告知率の調査も実施されていない.本研究では,北海道内の5つの医療機関において統合失調症患者とその主治医を対象として病名告知状況に関する調査を行った.対象患者全869名に対して主治医に対する調査票と患者に対する質問票により調査を行った.主治医から調査票を回収できたのは858名,患者への質問票を回収でき有効回答として利用できたのは529名であった.病名告知状況を調査するとともに,病名告知群と未告知群の背景を比較した.主治医調査票による病名告知状況の結果は,「統合失調症」と告知している患者が63.1%,「精神分裂病」と告知している患者が2.0%であり,合わせて65.0%であった.告知されているかどうか不明と主治医が回答した患者は18.4%であり,これを除外すると,「統合失調症」もしくは「精神分裂病」と告知している患者は79.6%に上った.患者質問票による病名の認識状況の結果は,「統合失調症」と回答した患者が55.2%,「精神分裂病」3.2%,その他の病名を答えた患者9.5%,病名を知らないと答えた患者17.4%,病名は知っていると回答したものの具体的には記載しなかった患者が14.7%であった.未記載の患者を除外すると,「統合失調症」もしくは「精神分裂病」と認識している患者は68.5%であった.病名告知群と未告知群との比較では,告知群は治療開始からの期間がより短く,調査時年齢もより低かった.治療開始時期が呼称変更された2002年より前の症例は未告知群で有意に多かった.この結果から,「統合失調症」への呼称変更や時代背景の変化により,病名告知がより積極的に行われるようになってきたことが示唆された.(著者抄録)
  • 全生活史健忘に関する臨床的検討
    大柳 有加, 賀古 勇輝, 三井 信幸, 久住 一郎 精神神経学雑誌 116 (6) 525 -526 2014年06月 [査読無し][通常論文]
  • 中井 幸衛, 井上 猛, 戸田 裕之, 豊巻 敦人, 中川 伸, 北市 雄士, 仲唐 安哉, 谷知 正章, 林下 善行, 三井 信幸, 橋本 直樹, 久住 一郎 精神神経学雑誌 115 (11) 1159 -1159 2013年11月 [査読無し][通常論文]
  • 大学生の自殺念慮および自傷傾向に関連する気質-性格特性について
    三井 信幸, 朝倉 聡, 小冷 碧, 豊島 邦義, 清水 祐輔, 賀古 勇輝, 田中 輝明, 井上 猛, 久住 一郎 精神神経学雑誌 115 (11) 1160 -1160 2013年11月 [査読無し][通常論文]
  • 統合失調症患者の病名告知に関する多施設調査
    賀古 勇輝, 大久保 亮, 清水 祐輔, 三井 信幸, 田中 輝明, 久住 一郎 精神神経学雑誌 (2013特別) S -380 2013年05月 [査読無し][通常論文]
  • 青年期の大うつ病性障害に伴う自殺念慮に関連する要因について
    三井 信幸, 朝倉 聡, 清水 祐輔, 藤井 泰, 賀古 勇輝, 田中 輝明, 久住 一郎 精神神経学雑誌 (2013特別) S -539 2013年05月 [査読無し][通常論文]
  • 脳炎および認知症との鑑別に苦慮した遅発緊張病の一例
    菊地 未紗子, 三井 信幸, 河合 剛多, 清水 祐輔, 藤井 泰, 賀古 勇輝, 北川 信樹, 中川 伸, 小山 司 精神神経学雑誌 (2012特別) S -436 2012年05月 [査読無し][通常論文]
  • 統合失調症患者の服薬観と関連する要因についての検討
    賀古 勇輝, 石田 七瀬, 清水 祐輔, 三井 信幸, 藤井 泰, 田中 輝明, 北川 信樹, 久住 一郎, 小山 司 精神神経学雑誌 (2011特別) S -201 2011年10月 [査読無し][通常論文]
  • 全般性社交不安障害の顔表情課題遂行時の機能画像に関する研究
    藤井 泰, 北川 信樹, 清水 祐輔, 三井 信幸, 賀古 勇輝, 田中 輝明, 朝倉 聡, 宮本 環, 小山 司 精神神経学雑誌 (2011特別) S -236 2011年10月 [査読無し][通常論文]
  • 統合失調症患者の病名告知と抑うつの関連についての検討
    大久保 亮, 賀古 勇輝, 清水 祐輔, 三井 信幸, 藤井 泰, 田中 輝明, 北川 信樹, 久住 一郎, 小山 司 精神神経学雑誌 (2011特別) S -362 2011年10月 [査読無し][通常論文]
  • 大うつ病性障害患者における認知機能障害と薬物療法の関連性についての検討
    清水 祐輔, 北川 信樹, 豊島 邦義, 三井 信幸, 藤井 泰, 賀古 勇輝, 田中 輝明, 小山 司 精神神経学雑誌 (2011特別) S -375 2011年10月 [査読無し][通常論文]
  • 気分障害患者の自殺傾向と転帰について 北大病院精神科神経科初診患者を対象とした調査
    上川 康友, 清水 祐輔, 三井 信幸, 藤井 泰, 賀古 勇輝, 北川 信樹, 小山 司 精神神経学雑誌 113 (4) 422 -422 2011年04月 [査読無し][通常論文]
  • 統合失調症患者の服薬アドヒアランスと関連する要因についての検討
    石田 七瀬, 賀古 勇輝, 清水 祐輔, 三井 信幸, 藤井 泰, 田中 輝明, 北川 信樹, 久住 一郎, 小山 司 精神神経学雑誌 113 (4) 423 -423 2011年04月 [査読無し][通常論文]
  • 豊島 邦義, 清水 祐輔, 三井 信幸, 藤井 泰, 賀古 勇輝, 田中 輝明, 朝倉 聡, 北川 信樹, 小山 司 精神科 18 (2) 238 -243 2011年02月 [査読無し][通常論文]
     
    三環系抗うつ薬からSSRIへ置換した後、様々な神経認知機能が改善し、職場に適応するなど社会機能回復を認めた大うつ病性障害(MDD)の1例(53歳男性)について報告した。本例のように、抑うつ症状改善後、社会機能障害をきたしてはじめて認知機能障害が疑われるMDD症例は少なくないが、認知機能検査を施行することで、臨床場面では検出困難な軽微な認知機能障害を検出することが可能であると思われた。障害の要因については、疾病そのものの経過や症状レベル、薬剤の影響など様々な側面を考慮する必要があるが、MDDの維持療法を行う際には、認知機能を考慮しながら薬剤変更を試みることには価値があると考えられた。
  • 三環系抗うつ薬からSSRIへの置換で認知機能が改善したうつ病の1例
    豊島 邦義, 清水 祐輔, 三井 信幸, 藤井 泰, 賀古 勇輝, 北川 信樹, 小山 司 精神神経学雑誌 112 (10) 1056 -1056 2010年10月 [査読無し][通常論文]
  • 修正型電気けいれん療法後のバルプロ酸による維持療法
    三井 信幸, 中川 伸, 黒河 泰夫, 朴 秀賢, 清水 祐輔, 藤井 泰, 賀古 勇樹, 北川 信樹, 井上 猛, 小山 司 精神神経学雑誌 (2010特別) S -422 2010年05月 [査読無し][通常論文]
  • 電気痙攣療法による症状改善後にバルプロ酸単剤による治療で長期間に亘る寛解を維持している精神病性うつ病の1症例
    朴 秀賢, 中川 伸, 三井 信幸, 鈴木 克治, 井上 猛, 小山 司 精神神経学雑誌 (2010特別) S -432 2010年05月 [査読無し][通常論文]
  • 社交不安障害の認知機能 予備的研究(2)
    藤井 泰, 北川 信樹, 清水 祐輔, 三井 信幸, 賀古 勇輝, 朝倉 聡, 小山 司 不安障害研究 2 (1) 159 -159 2010年03月 [査読無し][通常論文]
  • 医療観察法病棟における入院長期化の要因分析
    三井 信幸, 北川 信樹, 小山 司, 高橋 昇, 石丸 正吾, 中嶋 正人 精神神経学雑誌 112 (1) 78 -78 2010年01月 [査読無し][通常論文]
  • mECT後の維持療法に抗うつ薬とバルプロ酸の併用投与を行った反復性うつ病性障害の1例
    三井 信幸, 北川 信樹, 中川 伸, 小山 司 精神科 15 (5) 488 -492 2009年11月 [査読無し][通常論文]
     
    修正型電気けいれん療法(m-ECT)後の早期再燃予防の目的でバルプロ酸(VPA)を追加投与した反復性うつ病性障害の1例(49歳男性)について報告した。m-ECT後には早期に再燃する可能性が高く、確実な維持療法を行うことが課題となっている。本症例では職場復帰に伴う病状の不安定さはみられたが、m-ECT後の早期に抑うつ症状の再燃は認められず、VPAの併用療法が再燃予防に有効であった可能性が考えられた。
  • 三井 信幸, 石丸 正吾, 入野 康, 中嶋 正人, 吉住 昭 精神科 14 (5) 425 -429 2009年05月 [査読無し][通常論文]
     
    医療観察法入院における妄想性障害被害型の症例(40歳代男性)の治療経過について報告した。本症例は持続的な追跡妄想を主症状とし、まったく病識を欠いていたため未治療期間が長く、治療導入が困難であった。しかし、傷害事件を契機として医療観察法入院処遇へと導入され、医療観察法入院の枠組みの中で治療導入し、一定の治療効果が得られた。薬物療法としてはアリピプラゾルを選択し、妄想症状の軽減や病識の獲得などの効果が認められた。以上より、このような妄想性障害に対して医療観察法の入院による治療には一定の効果が期待できることが示唆された。
  • 医療観察法病棟における妄想性障害の治療経験
    三井 信幸, 石丸 正吾, 中嶋 正人, 吉住 昭 精神神経学雑誌 111 (5) 597 -597 2009年05月 [査読無し][通常論文]
  • 高用量ベンゾジアゼピン投与後にECTを行い寛解に至った緊張型統合失調症の1例
    三井 信幸, 工藤 浩, 黒河 泰夫 精神神経学雑誌 110 (6) 508 -508 2008年06月 [査読無し][通常論文]
  • 治療抵抗性気分障害に対するパルス波治療器を用いた修正型電気痙攣療法における痙攣閾値上昇についての後方視的検討
    Boku Shuken, 梶 直道, 井上 猛, 中川 伸, 鈴木 克治, 田中 輝明, 北市 雄士, 増井 拓哉, 仲唐 安哉, 三井 信幸, 小山 司 精神神経学雑誌 (2008特別) S -212 2008年05月 [査読無し][通常論文]
  • 大うつ病性障害における自殺既遂例の特徴および治療的介入の検討
    三井 信幸, 工藤 浩, 黒河 泰夫 精神神経学雑誌 109 (5) 498 -498 2007年05月 [査読無し][通常論文]
  • 大うつ病性障害における自殺念慮、自殺企図および自殺既遂例の検討
    三井 信幸, 工藤 浩, 黒河 泰夫 精神神経学雑誌 (2007特別) S146 -S146 2007年05月 [査読無し][通常論文]
  • 大うつ病性障害における自殺既遂例の特徴および治療的介入の検討
    三井 信幸, 工藤 浩, 黒河 泰夫 岩見沢市立総合病院医誌 33 (1) 31 -35 2007年05月 [査読無し][通常論文]
     
    自殺者がうつ病に罹患している割合は高く、うつ病治療は自殺予防という観点からも重要であると考えられるが、一方で抗うつ薬による自殺惹起の可能性も報告されている。そこで今回われわれは、当院受診後に自殺既遂に至ったうつ病症例18例について後方視的に調査した。その結果、平均年齢は男性が47.1歳、女性が61.4歳であり男性の方が有意に低かった。さらに初診時における自殺念慮の有無により分類したところ、自殺念慮を表出しなかった症例の方が早期に自殺既遂に至っていた。また、治療的介入について症例対照研究を行い、自殺念慮群において入院症例数が多く、抗うつ薬投与量も有意に多いという結果を得た。本研究では抗うつ薬による自殺惹起の可能性は確認できず、むしろ自殺念慮の表出がないことなどによる病状の過小評価に注意が必要であると考えられた。自殺念慮の表出と自殺既遂との関係についてさらに詳しく調査する必要があると思われた。(著者抄録)
  • 大うつ病性障害に対する電気けいれん療法後の維持療法
    三井 信幸, 中川 伸, 北市 雄士, 井上 猛, 小山 司 岩見沢市立総合病院医誌 32 (1) 15 -18 2006年05月 [査読無し][通常論文]
     
    電気けいれん療法electroconvulsive therapy(ECT)は,大うつ病性障害に対する有効率が80〜90%とも言われている.しかし同時に再燃率も高く,一年後には約半数が再燃するという報告もある.そこで今回われわれは,電気けいれん療法後の維持療法に関して,カルテ調査に基づく後方視的な検討を行った.その結果,電気けいれん療法の反応率は極めて高いものであったが,同時に再燃率は6ヵ月後に51.4%に及んだ.また,ECTの施行理由,使用したECT装置,副作用などについても比較検討した.ECT後の維持療法に関して,非再燃例でsodium valproate(VPA)や高用量のmilnacipranが使用されている例があった.現在までのところ,ECT後の維持療法は確立されておらず,これらの薬剤の再燃予防効果が期待されるため,今後更なる調査が必要であると思われる(著者抄録)
  • 単極性うつ病における電気けいれん療法後の維持療法について後方視的研究
    三井 信幸, 中川 伸, 北市 雄士, 井上 猛, 小山 司 精神神経学雑誌 108 (5) 539 -539 2006年05月 [査読無し][通常論文]
  • 完全静脈麻酔(TIVA)による腹部手術の一例
    三井 信幸 札幌社会保険総合病院医誌 14 (2) 164 -164 2005年12月 [査読無し][通常論文]
  • 急性冠症候群の一例
    三井 信幸 札幌社会保険総合病院医誌 14 (2) 166 -166 2005年12月 [査読無し][通常論文]
  • 慢性腎不全から透析導入に至った一例
    三井 信幸 札幌社会保険総合病院医誌 14 (1) 72 -72 2005年04月 [査読無し][通常論文]
  • 特発性下部消化器管穿孔を来した一例
    三井 信幸 札幌社会保険総合病院医誌 14 (1) 75 -75 2005年04月 [査読無し][通常論文]

所属学協会

  • 日本総合病院精神医学会   日本自殺予防学会   日本うつ病学会   日本精神神経学会   日本神経精神薬理学会   日本摂食障害学会   日本心身医学会   日本司法精神医学会   

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