早坂 孝宏ハヤサカ タカヒロresearchmap個人ページ

更新日 : 2017/12/02

基本情報

プロフィール

所属部署名
医学研究院  外科系部門外科学分野
職名特任助教 
学位
工学博士(芝浦工業大学)
メールアドレスthayahs.hokudai.ac.jp
ホームページURLhttp://kaken.nii.ac.jp/d/r/90415927.ja.html
科研費研究者番号

研究キーワード

加齢黄斑変性症, バイオマーカー, イメージング, 質量分析, 網膜, 脂質

研究分野

基礎医学 / 病態医化学
研究分野を全て表示する
研究分野閉じる
基礎医学 / 病態医化学

職歴

2014年05月
-
現在
北海道大学(特任助教)
2010年04月
-
2014年04月
浜松医科大学(特任助教)
2009年04月
-
2010年03月
浜松医科大学(特任助教)
2008年01月
-
2009年03月
浜松医科大学(特任研究員)
2004年08月
-
2007年12月
自然科学研究機構 岡崎統合バイオサイエンスセンター(専門研究職員)
2004年04月
-
2004年07月
三菱化学生命科学研究所(特別研究員)
2003年04月
-
2004年03月
JSTさきがけ(特別研究員)
職歴を全て表示する
職歴閉じる
2014年05月
-
現在
北海道大学(特任助教)
2010年04月
-
2014年04月
浜松医科大学(特任助教)
2009年04月
-
2010年03月
浜松医科大学(特任助教)
2008年01月
-
2009年03月
浜松医科大学(特任研究員)
2004年08月
-
2007年12月
自然科学研究機構 岡崎統合バイオサイエンスセンター(専門研究職員)
2004年04月
-
2004年07月
三菱化学生命科学研究所(特別研究員)
2003年04月
-
2004年03月
JSTさきがけ(特別研究員)

研究活動

論文

Increased phosphatidylcholine (16:0/16:0) in the folliculus lymphaticus of Warthin tumor.
He Q, Takizawa Y, Hayasaka T, Masaki N, Kusama Y, Su J, Mineta H, Setou M
Analytical and bioanalytical chemistry 2014年06月
Matrix-assisted laser desorption/ionization imaging mass spectrometry revealed traces of dental problem associated with dental structure.
Hirano H, Masaki N, Hayasaka T, Watanabe Y, Masumoto K, Nagata T, Katou F, Setou M
Analytical and bioanalytical chemistry 406 1355-1363 2014年02月
Imaging mass spectrometry distinguished the cancer and stromal regions of oral squamous cell carcinoma by visualizing phosphatidylcholine (16:0/16:1) and phosphatidylcholine (18:1/20:4).
Uchiyama Y, Hayasaka T, Masaki N, Watanabe Y, Masumoto K, Nagata T, Katou F, Setou M
Analytical and bioanalytical chemistry 406 1307-1316 2014年02月
Accumulated phosphatidylcholine (16:0/16:1) in human colorectal cancer; possible involvement of LPCAT4.
Kurabe N, Hayasaka T, Ogawa M, Masaki N, Ide Y, Waki M, Nakamura T, Kurachi K, Kahyo T, Shinmura K, Midorikawa Y, Sugiyama Y, Setou M, Sugimura H
Cancer science 104 1295-1302 2013年10月
Lysophosphatidylcholine acyltransferase 1 altered phospholipid composition and regulated hepatoma progression.
Morita Y, Sakaguchi T, Ikegami K, Goto-Inoue N, Hayasaka T, Hang VT, Tanaka H, Harada T, Shibasaki Y, Suzuki A, Fukumoto K, Inaba K, Murakami M, Setou M, Konno H
Journal of hepatology 59 292-299 2013年08月
Visualization of phosphatidylcholine (16:0/16:0) in type II alveolar epithelial cells in the human lung using imaging mass spectrometry.
Kurabe N, Hayasaka T, Igarashi H, Mori H, Sekihara K, Tao H, Yamada H, Kahyo T, Onishi I, Tsukui H, Kawase A, Matsuura S, Inoue Y, Shinmura K, Funai K, Setou M, Sugimura H
Pathology international 63 195-200 2013年04月
Adventitial vasa vasorum arteriosclerosis in abdominal aortic aneurysm.
Tanaka H, Zaima N, Sasaki T, Hayasaka T, Goto-Inoue N, Onoue K, Ikegami K, Morita Y, Yamamoto N, Mano Y, Sano M, Saito T, Sato K, Konno H, Setou M, Unno N
PloS one 8 e57398 2013年
Human breast cancer tissues contain abundant phosphatidylcholine(36∶1) with high stearoyl-CoA desaturase-1 expression.
Ide Y, Waki M, Hayasaka T, Nishio T, Morita Y, Tanaka H, Sasaki T, Koizumi K, Matsunuma R, Hosokawa Y, Ogura H, Shiiya N, Setou M
PloS one 8 e61204 2013年
Correction: Human Breast Cancer Tissues Contain Abundant Phosphatidylcholine(36∶1) with High Stearoyl-CoA Desaturase-1 Expression.
Ide Y, Waki M, Hayasaka T, Nishio T, Morita Y, Tanaka H, Sasaki T, Koizumi K, Matsunuma R, Hosokawa Y, Ogura H, Shiiya N, Setou M
PloS one 8 2013年
MALDI Imaging Mass Spectrometry-A Mini Review of Methods and Recent Developments.
Eriksson C, Masaki N, Yao I, Hayasaka T, Setou M
Mass spectrometry (Tokyo, Japan) 2 S0022 2013年
論文を全て表示する
論文閉じる
Increased phosphatidylcholine (16:0/16:0) in the folliculus lymphaticus of Warthin tumor.
He Q, Takizawa Y, Hayasaka T, Masaki N, Kusama Y, Su J, Mineta H, Setou M
Analytical and bioanalytical chemistry 2014年06月
Matrix-assisted laser desorption/ionization imaging mass spectrometry revealed traces of dental problem associated with dental structure.
Hirano H, Masaki N, Hayasaka T, Watanabe Y, Masumoto K, Nagata T, Katou F, Setou M
Analytical and bioanalytical chemistry 406 1355-1363 2014年02月
Imaging mass spectrometry distinguished the cancer and stromal regions of oral squamous cell carcinoma by visualizing phosphatidylcholine (16:0/16:1) and phosphatidylcholine (18:1/20:4).
Uchiyama Y, Hayasaka T, Masaki N, Watanabe Y, Masumoto K, Nagata T, Katou F, Setou M
Analytical and bioanalytical chemistry 406 1307-1316 2014年02月
Accumulated phosphatidylcholine (16:0/16:1) in human colorectal cancer; possible involvement of LPCAT4.
Kurabe N, Hayasaka T, Ogawa M, Masaki N, Ide Y, Waki M, Nakamura T, Kurachi K, Kahyo T, Shinmura K, Midorikawa Y, Sugiyama Y, Setou M, Sugimura H
Cancer science 104 1295-1302 2013年10月
Lysophosphatidylcholine acyltransferase 1 altered phospholipid composition and regulated hepatoma progression.
Morita Y, Sakaguchi T, Ikegami K, Goto-Inoue N, Hayasaka T, Hang VT, Tanaka H, Harada T, Shibasaki Y, Suzuki A, Fukumoto K, Inaba K, Murakami M, Setou M, Konno H
Journal of hepatology 59 292-299 2013年08月
Visualization of phosphatidylcholine (16:0/16:0) in type II alveolar epithelial cells in the human lung using imaging mass spectrometry.
Kurabe N, Hayasaka T, Igarashi H, Mori H, Sekihara K, Tao H, Yamada H, Kahyo T, Onishi I, Tsukui H, Kawase A, Matsuura S, Inoue Y, Shinmura K, Funai K, Setou M, Sugimura H
Pathology international 63 195-200 2013年04月
Adventitial vasa vasorum arteriosclerosis in abdominal aortic aneurysm.
Tanaka H, Zaima N, Sasaki T, Hayasaka T, Goto-Inoue N, Onoue K, Ikegami K, Morita Y, Yamamoto N, Mano Y, Sano M, Saito T, Sato K, Konno H, Setou M, Unno N
PloS one 8 e57398 2013年
Human breast cancer tissues contain abundant phosphatidylcholine(36∶1) with high stearoyl-CoA desaturase-1 expression.
Ide Y, Waki M, Hayasaka T, Nishio T, Morita Y, Tanaka H, Sasaki T, Koizumi K, Matsunuma R, Hosokawa Y, Ogura H, Shiiya N, Setou M
PloS one 8 e61204 2013年
Correction: Human Breast Cancer Tissues Contain Abundant Phosphatidylcholine(36∶1) with High Stearoyl-CoA Desaturase-1 Expression.
Ide Y, Waki M, Hayasaka T, Nishio T, Morita Y, Tanaka H, Sasaki T, Koizumi K, Matsunuma R, Hosokawa Y, Ogura H, Shiiya N, Setou M
PloS one 8 2013年
MALDI Imaging Mass Spectrometry-A Mini Review of Methods and Recent Developments.
Eriksson C, Masaki N, Yao I, Hayasaka T, Setou M
Mass spectrometry (Tokyo, Japan) 2 S0022 2013年
Visualization of dynamic change in contraction-induced lipid composition in mouse skeletal muscle by matrix-assisted laser desorption/ionization imaging mass spectrometry.
Goto-Inoue N, Manabe Y, Miyatake S, Ogino S, Morishita A, Hayasaka T, Masaki N, Setou M, Fujii NL
Analytical and bioanalytical chemistry 403 1863-1871 2012年06月
Identification of oligosaccharides from histopathological sections by MALDI imaging mass spectrometry.
Yamada M, Yao I, Hayasaka T, Ushijima M, Matsuura M, Takada H, Shikata N, Setou M, Kwon AH, Ito S
Analytical and bioanalytical chemistry 402 1921-1930 2012年02月
Imaging mass spectrometry evaluation of the effects of various irrigation fluids in a rat model of postoperative cerebral edema.
Koizumi S, Hayasaka T, Goto-Inoue N, Doi K, Setou M, Namba H
World neurosurgery 77 153-159 2012年01月
Composition and localization of lipids in Penaeus merguiensis ovaries during the ovarian maturation cycle as revealed by imaging mass spectrometry.
Chansela P, Goto-Inoue N, Zaima N, Hayasaka T, Sroyraya M, Kornthong N, Engsusophon A, Tamtin M, Chaisri C, Sobhon P, Setou M
PloS one 7 e33154 2012年
Development of imaging mass spectrometry.
Saito Y, Waki M, Hameed S, Hayasaka T, Setou M
Biological & pharmaceutical bulletin 35 1417-1424 2012年
Increased expression of phosphatidylcholine (16:0/18:1) and (16:0/18:2) in thyroid papillary cancer.
Ishikawa S, Tateya I, Hayasaka T, Masaki N, Takizawa Y, Ohno S, Kojima T, Kitani Y, Kitamura M, Hirano S, Setou M, Ito J
PloS one 7 e48873 2012年
Imaging mass spectrometry visualizes ceramides and the pathogenesis of dorfman-chanarin syndrome due to ceramide metabolic abnormality in the skin.
Goto-Inoue N, Hayasaka T, Zaima N, Nakajima K, Holleran WM, Sano S, Uchida Y, Setou M
PloS one 7 e49519 2012年
Imaging mass spectrometry for lipidomics.
Goto-Inoue N, Hayasaka T, Zaima N, Setou M
Biochimica et biophysica acta 1811 961-969 2011年11月
Imaging mass spectrometry analysis reveals an altered lipid distribution pattern in the tubular areas of hyper-IgA murine kidneys.
Kaneko Y, Obata Y, Nishino T, Kakeya H, Miyazaki Y, Hayasaka T, Setou M, Furusu A, Kohno S
Experimental and molecular pathology 91 614-621 2011年10月
Method for simultaneous imaging of endogenous low molecular weight metabolites in mouse brain using TiO2 nanoparticles in nanoparticle-assisted laser desorption/ionization-imaging mass spectrometry.
Shrivas K, Hayasaka T, Sugiura Y, Setou M
Analytical chemistry 83 7283-7289 2011年10月
Imaging mass spectrometry-based histopathologic examination of atherosclerotic lesions.
Zaima N, Sasaki T, Tanaka H, Cheng XW, Onoue K, Hayasaka T, Goto-Inoue N, Enomoto H, Unno N, Kuzuya M, Setou M
Atherosclerosis 217 427-432 2011年08月
Development of imaging mass spectrometry (IMS) dataset extractor software, IMS convolution.
Hayasaka T, Goto-Inoue N, Ushijima M, Yao I, Yuba-Kubo A, Wakui M, Kajihara S, Matsuura M, Setou M
Analytical and bioanalytical chemistry 401 183-193 2011年07月
Authenticity assessment of beef origin by principal component analysis of matrix-assisted laser desorption/ionization mass spectrometric data.
Zaima N, Goto-Inoue N, Hayasaka T, Enomoto H, Setou M
Analytical and bioanalytical chemistry 400 1865-1871 2011年06月
Abnormal phospholipids distribution in the prefrontal cortex from a patient with schizophrenia revealed by matrix-assisted laser desorption/ionization imaging mass spectrometry.
Matsumoto J, Sugiura Y, Yuki D, Hayasaka T, Goto-Inoue N, Zaima N, Kunii Y, Wada A, Yang Q, Nishiura K, Akatsu H, Hori A, Hashizume Y, Yamamoto T, Ikemoto K, Setou M, Niwa S
Analytical and bioanalytical chemistry 400 1933-1943 2011年06月
Imaging mass spectrometry reveals characteristic changes in triglyceride and phospholipid species in regenerating mouse liver.
Miyamura N, Nakamura T, Goto-Inoue N, Zaima N, Hayasaka T, Yamasaki T, Terai S, Sakaida I, Setou M, Nishina H
Biochemical and biophysical research communications 408 120-125 2011年04月
Salamander retina phospholipids and their localization by MALDI imaging mass spectrometry at cellular size resolution.
Roy MC, Nakanishi H, Takahashi K, Nakanishi S, Kajihara S, Hayasaka T, Setou M, Ogawa K, Taguchi R, Naito T
Journal of lipid research 52 463-470 2011年03月
New approach for glyco- and lipidomics--molecular scanning of human brain gangliosides by TLC-Blot and MALDI-QIT-TOF MS.
Valdes-Gonzalez T, Goto-Inoue N, Hirano W, Ishiyama H, Hayasaka T, Setou M, Taki T
Journal of neurochemistry 116 678-683 2011年03月
New Approach for Glyco- and Lipidomics - Molecular Scanning of Human Brain Gangliosides by TLC-Blot and MALDI-TOF MS -
Valdes-Gonzalez T, Goto-Inoue N, Hirano W, Ishiyama H, Hayasaka T, Setou M, Taki T
Journal of neurochemistry 2011年01月
Specific localization of five phosphatidylcholine species in the cochlea by mass microscopy.
Takizawa Y, Mizuta K, Hayasaka T, Nakanishi H, Okamura J, Mineta H, Setou M
Audiology & neuro-otology 16 315-322 2011年
Investigation by imaging mass spectrometry of biomarker candidates for aging in the hair cortex.
Waki ML, Onoue K, Takahashi T, Goto K, Saito Y, Inami K, Makita I, Angata Y, Suzuki T, Yamashita M, Sato N, Nakamura S, Yuki D, Sugiura Y, Zaima N, Goto-Inoue N, Hayasaka T, Shimomura Y, Setou M
PloS one 6 e26721 2011年
The detection of glycosphingolipids in brain tissue sections by imaging mass spectrometry using gold nanoparticles.
Goto-Inoue N, Hayasaka T, Zaima N, Kashiwagi Y, Yamamoto M, Nakamoto M, Setou M
Journal of the American Society for Mass Spectrometry 21 1940-1943 2010年11月
Ionic matrix for enhanced MALDI imaging mass spectrometry for identification of phospholipids in mouse liver and cerebellum tissue sections.
Shrivas K, Hayasaka T, Goto-Inoue N, Sugiura Y, Zaima N, Setou M
Analytical chemistry 82 8800-8806 2010年11月
Application of imaging mass spectrometry for the analysis of Oryza sativa rice.
Zaima N, Goto-Inoue N, Hayasaka T, Setou M
Rapid communications in mass spectrometry : RCM 24 2723-2729 2010年09月
Imaging mass spectrometry with silver nanoparticles reveals the distribution of fatty acids in mouse retinal sections.
Hayasaka T, Goto-Inoue N, Zaima N, Shrivas K, Kashiwagi Y, Yamamoto M, Nakamoto M, Setou M
Journal of the American Society for Mass Spectrometry 21 1446-1454 2010年08月
Developments and applications of mass microscopy.
Setou M, Shrivas K, Sroyraya M, Yang H, Sugiura Y, Moribe J, Kondo A, Tsutsumi K, Kimura Y, Kurabe N, Hayasaka T, Goto-Inoue N, Zaima N, Ikegami K, Sobhon P, Konishi Y
Medical molecular morphology 43 1-5 2010年03月
Imaging mass spectrometry of gastric carcinoma in formalin-fixed paraffin-embedded tissue microarray.
Morita Y, Ikegami K, Goto-Inoue N, Hayasaka T, Zaima N, Tanaka H, Uehara T, Setoguchi T, Sakaguchi T, Igarashi H, Sugimura H, Setou M, Konno H
Cancer science 101 267-273 2010年01月
Matrix-assisted laser desorption/ionization imaging mass spectrometry.
Zaima N, Hayasaka T, Goto-Inoue N, Setou M
International journal of molecular sciences 11 5040-5055 2010年
Imaging mass spectrometry of glycolipids.
Goto-Inoue N, Hayasaka T, Setou M
Methods in enzymology 478 287-301 2010年
Visualization of volatile substances in different organelles with an atmospheric-pressure mass microscope.
Harada T, Yuba-Kubo A, Sugiura Y, Zaima N, Hayasaka T, Goto-Inoue N, Wakui M, Suematsu M, Takeshita K, Ogawa K, Yoshida Y, Setou M
Analytical chemistry 81 9153-9157 2009年11月
A new lipidomics approach by thin-layer chromatography-blot-matrix-assisted laser desorption/ionization imaging mass spectrometry for analyzing detailed patterns of phospholipid molecular species.
Goto-Inoue N, Hayasaka T, Taki T, Gonzalez TV, Setou M
Journal of chromatography. A 1216 7096-7101 2009年10月
The specific localization of seminolipid molecular species on mouse testis during testicular maturation revealed by imaging mass spectrometry.
Goto-Inoue N, Hayasaka T, Zaima N, Setou M
Glycobiology 19 950-957 2009年09月
Organ-specific distributions of lysophosphatidylcholine and triacylglycerol in mouse embryo.
Hayasaka T, Goto-Inoue N, Zaima N, Kimura Y, Setou M
Lipids 44 837-848 2009年09月
TLC blot (far-eastern blot) and its applications.
Taki T, Gonzalez TV, Goto-Inoue N, Hayasaka T, Setou M
Methods in molecular biology (Clifton, N.J.) 536 545-556 2009年
Imaging of metabolites by MALDI mass spectrometry.
Zaima N, Hayasaka T, Goto-Inoue N, Setou M
Journal of oleo science 58 415-419 2009年
Matrix-assisted laser desorption/ionization quadrupole ion trap time-of-flight (MALDI-QIT-TOF)-based imaging mass spectrometry reveals a layered distribution of phospholipid molecular species in the mouse retina.
Hayasaka T, Goto-Inoue N, Sugiura Y, Zaima N, Nakanishi H, Ohishi K, Nakanishi S, Naito T, Taguchi R, Setou M
Rapid communications in mass spectrometry : RCM 22 3415-3426 2008年11月
N-acetyltransferase ARD1-NAT1 regulates neuronal dendritic development.
Ohkawa N, Sugisaki S, Tokunaga E, Fujitani K, Hayasaka T, Setou M, Inokuchi K
Genes to cells : devoted to molecular & cellular mechanisms 13 1171-1183 2008年11月
High-sensitivity analysis of glycosphingolipids by matrix-assisted laser desorption/ionization quadrupole ion trap time-of-flight imaging mass spectrometry on transfer membranes.
Goto-Inoue N, Hayasaka T, Sugiura Y, Taki T, Li YT, Matsumoto M, Setou M
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 870 74-83 2008年07月
Mass imaging and identification of biomolecules with MALDI-QIT-TOF-based system.
Shimma S, Sugiura Y, Hayasaka T, Zaima N, Matsumoto M, Setou M
Analytical chemistry 80 878-885 2008年02月
MALDI-based imaging mass spectrometry revealed abnormal distribution of phospholipids in colon cancer liver metastasis.
Shimma S, Sugiura Y, Hayasaka T, Hoshikawa Y, Noda T, Setou M
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 855 98-103 2007年08月
Axonal transport versus dendritic transport.
Setou M, Hayasaka T, Yao I
Journal of neurobiology 58 201-206 2004年02月
Oxidative damage of rat cerebral cortex and hippocampus, and changes in antioxidative defense systems caused by hyperoxia.
Onodera K, Omoi NO, Fukui K, Hayasaka T, Shinkai T, Suzuki S, Abe K, Urano S
Free radical research 37 367-372 2003年04月
Cognitive impairment of rats caused by oxidative stress and aging, and its prevention by vitamin E.
Fukui K, Omoi NO, Hayasaka T, Shinnkai T, Suzuki S, Abe K, Urano S
Annals of the New York Academy of Sciences 959 275-284 2002年04月

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