研究者データベース

小林 康明(コバヤシ ヤスアキ)
電子科学研究所 附属社会創造数学研究センター
准教授

基本情報

所属

  • 電子科学研究所 附属社会創造数学研究センター

職名

  • 准教授

学位

  • 博士(理学)(東京大学)

科研費研究者番号

  • 50455622

J-Global ID

研究キーワード

  • パターン形成   反応拡散系   数理モデリング   

研究分野

  • 自然科学一般 / 生物物理、化学物理、ソフトマターの物理
  • 自然科学一般 / 応用数学、統計数学

所属学協会

  • 日本物理学会   日本応用数理学会   

研究活動情報

論文

  • Minsoo Kim, Mamoru Okamoto, Yusuke Yasugahira, Shinpei Tanaka, Satoshi Nakata, Yasuaki Kobayashi, Masaharu Nagayama
    Physica D: Nonlinear Phenomena 425 132949  2021年06月 [査読有り]
     
    We experimentally and numerically investigate collective behaviors of oil droplets floating on a surfactant solution in a narrow circular channel. A closed environment where a glass cover is placed on the channel shown that ethyl salicylate droplets on the surface of sodium dodecyl sulfate solution exhibit transient oscillatory dynamics, leading to the formation of a single cluster via the merging of sub-clusters. When the glass cover is removed, oscillatory behavior resumes, and the cluster breaks up. To understand these experimental findings, we introduce a mathematical model that combines equations of motion for droplets with a reaction–diffusion system, where droplet dynamics and the chemical reactions are considered on the one-dimensional surface, and the diffusion of chemicals in the air phase and the water phase is treated in the two-dimensional region. Our model successfully reproduces transient oscillations and the characteristics of cluster formation, and the effect of the glass cover. We argue that the attractive long-range interaction due to the global concentration profile of the solution suffices for the cluster formation.
  • Masashi Nakatani, Yasuaki Kobayashi, Kota Ohno, Masaaki Uesaka, Sayako Mogami, Zixia Zhao, Takamichi Sushida, Hiroyuki Kitahata, Masaharu Nagayama
    Scientific Reports 11 11737  2021年06月 [査読有り]
     
    The human hand can detect both form and texture information of a contact surface. The detection of skin displacement (sustained stimulus) and changes in skin displacement (transient stimulus) are thought to be mediated in different tactile channels; however, tactile form perception may use both types of information. Here, we studied whether both the temporal frequency and the temporal coherency information of tactile stimuli encoded in sensory neurons could be used to recognize the form of contact surfaces. We used the fishbone tactile illusion (FTI), a known tactile phenomenon, as a probe for tactile form perception in humans. This illusion typically occurs with a surface geometry that has a smooth bar and coarse textures in its adjacent areas. When stroking the central bar back and forth with a fingertip, a human observer perceives a hollow surface geometry even though the bar is physically flat. We used a passive high-density pin matrix to extract only the vertical information of the contact surface, suppressing tangential displacement from surface rubbing. Participants in the psychological experiment reported indented surface geometry by tracing over the FTI textures with pin matrices of the different spatial densities (1.0 and 2.0 mm pin intervals). Human participants reported that the relative magnitude of perceived surface indentation steeply decreased when pins in the adjacent areas vibrated in synchrony. To address possible mechanisms for tactile form perception in the FTI, we developed a computational model of sensory neurons to estimate temporal patterns of action potentials from tactile receptive fields. Our computational data suggest that (1) the temporal asynchrony of sensory neuron responses is correlated with the relative magnitude of perceived surface indentation and (2) the spatiotemporal change of displacements in tactile stimuli are correlated with the asynchrony of simulated sensory neuron responses for the fishbone surface patterns. Based on these results, we propose that both the frequency and the asynchrony of temporal activity in sensory neurons could produce tactile form perception.
  • Kota Ohno, Yasuaki Kobayashi, Masaaki Uesaka, Takeshi Gotoda, Mitsuhiro Denda, Hideyuki Kosumi, Mika Watanabe, Ken Natsuga, Masaharu Nagayama
    Scientific Reports 11 13234  2021年06月 [査読有り]
     
    The skin barrier is provided by the organized multi-layer structure of epidermal cells, which is dynamically maintained by a continuous supply of cells from the basal layer. The epidermal homeostasis can be disrupted by various skin diseases, which often cause morphological changes not only in the epidermis but in the dermis. We present a three-dimensional agent-based computational model of the epidermis that takes into account the deformability of the dermis. Our model can produce a stable epidermal structure with well-organized layers. We show that its stability depends on the cell supply rate from the basal layer. Modeling the morphological change of the dermis also enables us to investigate how the stiffness of the dermis affects the structure and barrier functions of the epidermis. Besides, we show that our model can simulate the formation of a corn (clavus) by assuming hyperproliferation and rapid differentiation. We also provide experimental data for human corn, which supports the model assumptions and the simulation result.
  • Junichi Kumamoto, Koji Fujimoto, Yasuaki Kobayashi, Kota Ohno, Masaharu Nagayama, Mitsuhiro Denda
    Skin Research and Technology 2021年 [査読有り]
     
    Background: We showed previously that a thick three-dimensional epidermal equivalent can be constructed with passaged keratinocytes on a patterned surface. Material and Methods: We first carried out computer simulations of a three-dimensional epidermal equivalent model built on close-packed arrays of 10 µm, 15 µm, 20 µm, 30 µm, and 60 µm diameter pillars. Based on these predictions, we evaluated epidermal equivalents built on a series of porous plastic membranes bearing arrays of pillars 15 µm, 20 µm, 25 µm, 30 µm, and 50 µm in diameter. Results: The simulations predicted that a model having near-physiological thickness would be formed on 15 ~ 30 µm pillars. In the results of in vitro study, the thickest epidermal equivalent was obtained on the 20 µm pillars. Epidermal differentiation markers, filaggrin and loricrin, were expressed at the upper layer of the epidermal equivalent model, and tight-junction proteins, claudin-1 and ZO-1, were expressed on the cell membranes. BrdU-positive cells were observed at the base and also at the top of the pillars. Conclusion: The results of the study suggested that mathematical modeling might be a useful tool to guide biological studies.
  • Yu Fujimura, Mika Watanabe, Kota Ohno, Yasuaki Kobayashi, Shota Takashima, Hideki Nakamura, Hideyuki Kosumi, Yunan Wang, Yosuke Mai, Andrea Lauria, Valentina Proserpio, Hideyuki Ujiie, Hiroaki Iwata, Wataru Nishie, Masaharu Nagayama, Salvatore Oliviero, Giacomo Donati, Hiroshi Shimizu, Ken Natsuga
    EMBO Reports 2021年 [査読有り]
     
    Injury in adult tissue generally reactivates developmental programs to foster regeneration, but it is not known whether this paradigm applies to growing tissue. Here, by employing blisters, we show that epidermal wounds heal at the expense of skin development. The regenerated epidermis suppresses the expression of tissue morphogenesis genes accompanied by delayed hair follicle (HF) growth. Lineage tracing experiments, cell proliferation dynamics, and mathematical modeling reveal that the progeny of HF junctional zone stem cells, which undergo a morphological transformation, repair the blisters while not promoting HF development. In contrast, the contribution of interfollicular stem cell progeny to blister healing is small. These findings demonstrate that HF development can be sacrificed for the sake of epidermal wound regeneration. Our study elucidates the key cellular mechanism of wound healing in skin blistering diseases.
  • Kumamoto J, Nakanishi S, Makita M, Uesaka M, Yasugahira Y, Kobayashi Y, Nagayama M, Denda S, Denda M
    Scientific reports 8 1 17999  2018年12月 [査読有り][通常論文]
  • Kobayashi Y, Yasugahira Y, Kitahata H, Watanabe M, Natsuga K, Nagayama M
    npj Computational Materials 4 45  2018年08月 [査読有り][通常論文]
  • Yasuaki Kobayashi, Hiroyuki Kitahata, Masaharu Nagayama
    PHYSICAL REVIEW E 96 2 022213  2017年08月 [査読有り][通常論文]
     
    We investigate a two-dimensional spatially extended system that has a weak sense of excitability, where an excitation wave has a uniform profile and propagates only within a finite range. Using a cellular automaton model of such a weakly excitable system, we show that three kinds of sustained dynamics emerge when nonlocal spatial interactions are provided, where a chain of local wave propagation and nonlocal activation forms an elementary oscillatory cycle. Transition between different oscillation regimes can be understood as different ways of interactions among these cycles. Analytical expressions are given for the oscillation probability near the onset of oscillations.
  • Mika Watanabe, Ken Natsuga, Wataru Nishie, Yasuaki Kobayashi, Giacomo Donati, Shotaro Suzuki, Yu Fujimura, Tadasuke Tsukiyama, Hideyuki Ujiie, Satoru Shinkuma, Hideki Nakamura, Masamoto Murakami, Michitaka Ozaki, Masaharu Nagayama, Fiona M. Watt, Hiroshi Shimizu
    ELIFE 6 e26635  2017年07月 [査読有り][通常論文]
     
    Type XVII collagen (COL17) is a transmembrane protein located at the epidermal basement membrane zone. COL17 deficiency results in premature hair aging phenotypes and in junctional epidermolysis bullosa. Here, we show that COL17 plays a central role in regulating interfollicular epidermis (IFE) proliferation. Loss of COL17 leads to transient IFE hypertrophy in neonatal mice owing to aberrant Wnt signaling. The replenishment of COL17 in the neonatal epidermis of COL17-null mice reverses the proliferative IFE phenotype and the altered Wnt signaling. Physical aging abolishes membranous COL17 in IFE basal cells because of inactive atypical protein kinase C signaling and also induces epidermal hyperproliferation. The overexpression of human COL17 in aged mouse epidermis suppresses IFE hypertrophy. These findings demonstrate that COL17 governs IFE proliferation of neonatal and aged skin in distinct ways. Our study indicates that COL17 could be an important target of anti-aging strategies in the skin.
  • Y. Kobayashi, H. Kori
    CHAOS 26 9 094805  2016年09月 [査読有り][通常論文]
     
    We investigate synchronization in complex networks of noisy phase oscillators. We find that, while too weak a coupling is not sufficient for the whole system to synchronize, too strong a coupling induces a nontrivial type of phase slip among oscillators, resulting in synchronization failure. Thus, an intermediate coupling range for synchronization exists, which becomes narrower when the network is more heterogeneous. Analyses of two noisy oscillators reveal that nontrivial phase slip is a generic phenomenon when noise is present and coupling is strong. Therefore, the low synchronizability of heterogeneous networks can be understood as a result of the difference in effective coupling strength among oscillators with different degrees; oscillators with high degrees tend to undergo phase slip while those with low degrees have weak coupling strengths that are insufficient for synchronization. Published by AIP Publishing.
  • Yasuaki Kobayashi, Yusuke Sawabu, Hiroyuki Kitahata, Mitsuhiro Denda, Masaharu Nagayama
    JOURNAL OF THEORETICAL BIOLOGY 397 52 - 60 2016年05月 [査読有り][通常論文]
     
    Using a mathematical model of the epidermis, we propose a mechanism of epidermal homeostasis mediated by calcium dynamics. We show that calcium dynamics beneath the stratum corneum can reduce spatio-temporal fluctuations of the layered structure of the epidermis. We also demonstrate that our model can reproduce experimental results that the recovery from a barrier disruption is faster when the disrupted site is exposed to air. In particular, simulation results indicate that the recovery speed depends on the size of barrier disruption. (C) 2016 The Authors. Published by Elsevier Ltd.
  • Yasuaki Kobayashi, Masaharu Nagayama
    APPLICATIONS + PRACTICAL CONCEPTUALIZATION + MATHEMATICS = FRUITFUL INNOVATION 11 121 - 126 2016年 [査読有り][通常論文]
     
    Using a mathematical model of the epidermis, we investigate how the structure of the dermis affects the spatio-temporal pattern of the upper structure, especially the stratum corneum (SC). We find that, while large scale undulations greatly affects the upper structure, small scale undulations do not propagate into the upper structure, which is consistent with experimentally observed cross sections of the epidermis.
  • Yasuaki Kobayashi, Hiroyuki Kitahata, Masaharu Nagayama
    PHYSICAL REVIEW E 92 2 022709  2015年08月 [査読有り][通常論文]
     
    We propose a reaction-advection-diffusion model of epidermis consisting of two variables, the degree of differentiation and the calcium ion concentration, where calcium ions enhance differentiation. By analytically and numerically investigating this system, we show that a calcium localization layer formed beneath the stratum corneum helps reduce spatiotemporal fluctuations of the structure of the stratum corneum. In particular, spatially or temporally small-scale fluctuations in the lower structure are suppressed and do not affect the upper structure, due to acceleration of differentiation by calcium ions. Analytical expressions for the reduction rate of fluctuation amplitudes are shown.
  • Yasuaki Kobayashi, Yusuke Sawabu, Satoshi Ota, Masaharu Nagayama
    Mathematical Progress in Expressive Image Synthesis II 18 119 - 123 2015年06月 [査読有り][通常論文]
  • Yasuaki Kobayashi, Hiroshi Kori
    Physical Review E - Statistical, Nonlinear, and Soft Matter Physics 91 1 2015年01月05日 [査読有り][通常論文]
     
    We report on a synchronization-breaking instability observed in a noisy oscillator unidirectionally coupled to a pacemaker. Using a phase oscillator model, we find that, as the coupling strength is increased, the noisy oscillator lags behind the pacemaker more frequently and the phase slip rate increases, which may not be observed in averaged phase models such as the Kuramoto model. Investigation of the corresponding Fokker-Planck equation enables us to obtain the reentrant transition line between the synchronized state and the phase slip state. We verify our theory using the Brusselator model, suggesting that this reentrant transition can be found in a wide range of limit cycle oscillators.
  • Yasuaki Kobayashi, Hiroshi Kori
    PHYSICAL REVIEW E 91 1 012901  2015年01月 [査読有り][通常論文]
     
    We report on a synchronization-breaking instability observed in a noisy oscillator unidirectionally coupled to a pacemaker. Using a phase oscillator model, we find that, as the coupling strength is increased, the noisy oscillator lags behind the pacemaker more frequently and the phase slip rate increases, which may not be observed in averaged phase models such as the Kuramoto model. Investigation of the corresponding Fokker-Planck equation enables us to obtain the reentrant transition line between the synchronized state and the phase slip state. We verify our theory using the Brusselator model, suggesting that this reentrant transition can be found in a wide range of limit cycle oscillators.
  • Yasuaki Kobayashi, Yumi Sanno, Akihiko Sakai, Yusuke Sawabu, Moe Tsutsumi, Makiko Goto, Hiroyuki Kitahata, Satoshi Nakata, Junichi Kumamoto, Mitsuhiro Denda, Masaharu Nagayama
    PLOS ONE 9 3 e92650  2014年03月 [査読有り][通常論文]
     
    Recent studies have shown that the behavior of calcium in the epidermis is closely related to the conditions of the skin, especially the differentiation of the epidermal keratinocytes and the permeability barrier function, and therefore a correct understanding of the calcium dynamics is important in explaining epidermal homeostasis. Here we report on experimental observations of in vitro calcium waves in keratinocytes induced by mechanical stimulation, and present a mathematical model that can describe the experimentally observed wave behavior that includes finite-range wave propagation and a ring-shaped pattern. A mechanism of the ring formation hypothesized by our model may be related to similar calcium propagation patterns observed during the wound healing process in the epidermis. We discuss a possible extension of our model that may serve as a tool for investigating the mechanisms of various skin diseases.
  • Mitsuhiro Denda, Sumiko Denda, Moe Tsutsumi, Makiko Goto, Junichi Kumamoto, Masashi Nakatani, Kentaro Takei, Hiroyuki Kitahata, Satoshi Nakata, Yusuke Sawabu, Yasuaki Kobayashi, Masaharu Nagayama
    EXPERIMENTAL DERMATOLOGY 23 2 79 - 82 2014年02月 [査読有り][通常論文]
     
    Intact epidermal barrier function is crucial for survival and is associated with the presence of gradients of both calcium ion concentration and electric potential. Although many molecules, including ion channels and pumps, are known to contribute to maintenance of these gradients, the mechanisms involved in epidermal calcium ion dynamics have not been clarified. We have established that a variety of neurotransmitters and their receptors, originally found in the brain, are expressed in keratinocytes and are also associated with barrier homeostasis. Moreover, keratinocytes and neurons show some similarities of electrochemical behaviour. As mathematical modelling and computer simulation have been employed to understand electrochemical phenomena in brain science, we considered that a similar approach might be applicable to describe the dynamics of epidermal electrochemical phenomena associated with barrier homeostasis. Such methodology would also be potentially useful to address a number of difficult problems in clinical dermatology, such as ageing and itching. Although this work is at a very early stage, in this essay, we discuss the background to our approach and we present some preliminary results of simulation of barrier recovery.
  • Yasuaki Kobayashi, Tatsuo Shibata, Yoshiki Kuramoto, Alexander S. Mikhailov
    PHYSICAL REVIEW E 83 6 060901(R)  2011年06月 [査読有り][通常論文]
     
    Complex combinatorial optimization can be used to design network systems having desired dynamics and that are robust against structural perturbations. Here genetic networks exhibiting limit-cycle oscillations with prescribed periods and, furthermore, that are robust against the deletion of links and nodes or the application of noise are constructed. Large ensembles of robust genetic clocks with different periods could thus be obtained, and some of their statistical properties have been investigated. Similar methods can be used to design robust network oscillators of various origins.
  • Y. Kobayashi, T. Shibata, Y. Kuramoto, A. S. Mikhailov
    EUROPEAN PHYSICAL JOURNAL B 76 1 167 - 178 2010年07月 [査読有り][通常論文]
     
    The present study is devoted to the design and statistical investigations of dynamical gene expression networks. In our model problem, we aim to design genetic networks which would exhibit stable periodic oscillations with a prescribed temporal period. While no rational solution of this problem is available, we show that it can be effectively solved by running a computer evolution of the network models. In this process, structural rewiring mutations are applied to the networks with inhibitory interactions between genes and the evolving networks are selected depending on whether, after a mutation, they closer approach the targeted dynamics. We show that, by using this method, networks with required oscillation periods, varying by up to three orders of magnitude, can be constructed by changing the architecture of regulatory connections between the genes. Statistical properties of designed networks, including motif distributions and Laplacian spectra, are considered.
  • Yasuaki Kobayashi, Hiroshi Kori
    NEW JOURNAL OF PHYSICS 11 033018  2009年03月 [査読有り][通常論文]
     
    A theoretical framework is developed for the precise control of spatial patterns in oscillatory media using nonlinear global feedback, where a proper form of the feedback function corresponding to a specific pattern is predicted through the analysis of a phase diffusion equation with global coupling. In particular, feedback functions that generate the following spatial patterns are analytically given: (i) 2-cluster states with an arbitrary population ratio, (ii) equally populated multi-cluster states and (iii) a desynchronized state. Our method is demonstrated numerically by using the Brusselator model in the oscillatory regime. Experimental realization is also discussed.
  • Y Kobayashi, M Sano
    PROGRESS OF THEORETICAL PHYSICS SUPPLEMENT 161 161 236 - 239 2006年 [査読有り][通常論文]
     
    We construct a reaction-advection-diffusion model which shows a transition of patterns from aggregated spots to a closed loop structure, which has been observed in a recent gas-discharge experiment. Our model is based on the Gray-Scott model which is supplemented with a global coupling term due to an experimental constraint and advection terms which is induced by the discharge current.
  • Y Kobayashi, M Sano
    PHYSICAL REVIEW E 73 1 015104(R)  2006年01月 [査読有り][通常論文]
     
    We construct a phenomenological model describing aggregated spots and a loop structure. Our model is based on the Gray-Scott model which is supplemented with a global coupling term and advection terms. One of the species makes a field proportional to its concentration, which induces the advection. By numerically investigating the model, we show that the system has a transition from aggregated spots to a loop which wanders around chaotically or reaches a stationary state. Relation to a similar transition observed in a recent gas discharge experiment [S. Nasuno, Chaos 13, 3 (2003)] is discussed.
  • Y Kobayashi, M Sano
    JOURNAL OF THE PHYSICAL SOCIETY OF JAPAN 73 10 2697 - 2700 2004年10月 [査読有り][通常論文]
     
    We numerically investigate the nonequilibrium steady state of a one-dimensional rarefied granular system in which each particle is driven by Gaussian white noise and subject to inelastic mutual collisions. We find that the dynamic structure factor S(q, t) decays as exp(-Dq(2)t(2)), which is in marked contrast to the usual Fickian behavior exp(-Dq(2)t). Employing newly obtained S(q, t), we demonstrate that the static spatial correlation function and the one-point time correlation function obey the same scaling behavior.

講演・口頭発表等

  • Dynamics and distribution of epidermal stem cells on a membrane  [招待講演]
    Yasuaki Kobayashi, Masaharu Nagayama
    A3-NIMS Joint Workshop on Mathematical Biology, the National Institute of Mathematical Sciences, Daejeon, South Korea 2017年03月 口頭発表(招待・特別)
  • Modeling of phase-shifted oscillatory signals driven by Hes7 oscillations  [通常講演]
    Yasuaki Kobayashi, Hiroshi Kori
    5th Annual Winter q-bio Meeting in Kauai, Grand Hyatt Kauai, Hawaii, U.S.A. 2017年02月
  • Synchronization failure caused by interplay between noise and network heterogeneity  [通常講演]
    Yasuaki Kobayashi, Hiroshi Kori
    International Conference Patterns and Waves 2016, Hokkaido University Confer- ence Hall, Sapporo, Japan 2016年08月
  • Synchronization failure caused by interplay between noise and network hetero- geneity  [通常講演]
    Yasuaki Kobayashi, Hiroshi Kori
    NetSci2016: International School and Conference on Network Science, K-Hotel, Seoul, South Korea 2016年05月
  • Reentrant transition in coupled noisy oscillators  [通常講演]
    Yasuaki Kobayashi, Hiroshi Kori
    International Workshop: New Frontiers in Nonlinear Sciences, Hotel KAN- RONOMORI, Niseko, Japan 2016年03月
  • Reaction-advection-diffusion model of the epidermis  [通常講演]
    Yasuaki Kobayashi, Hiroyuki Kitahata, Masaharu Nagayama
    CIAM 2015, Convention Center, Beijing, China 2015年08月
  • Reaction-advection-diffusion model of the epidermis  [通常講演]
    Yasuaki Kobayashi, Masaharu Nagayama
    One-Day Workshop on Applied Mathematics, Tamkang University, Taipei 2015年03月
  • Mathematical model of the epidermal axon growth  [通常講演]
    Yasuaki Kobayashi, Moe Tsutsumi, Junichi Kumamoto, Mitsuhiro Denda, Masaharu Nagayama
    Neuroscience 2014, Washington D.C., U.S.A. 2014年11月
  • Mathematical model for epidermal homeostasis  [招待講演]
    Yasuaki Kobayashi, Yusuke Sawabu, Misaki. Kubo, Masaharu Nagayama
    MATHEMATICAL PROGRESS IN EXPRESSIVE IMAGE SYNTHESIS 2014, Nishijin Plaza, Fukuoka, Japan 2014年11月
  • Mathematical modeling for epidermal structure  [招待講演]
    Yasuaki Kobayashi, Yusuke Sawabu, Misaki. Kubo, Masaharu Nagayama
    FMI2014 -Applications + Practical Conceptualization + Mathematics = fruitful Innovation-, Nishijin Plaza, Fukuoka, Japan 2014年10月
  • Mathematical modeling of epidermal homeostasis  [通常講演]
    Yasuaki Kobayashi, Yusuke Sawabu, Masaharu Nagayama
    Czech-Japanese Seminar in Applied Math- ematics, Meiji University 2013年09月
  • Evolutionary design of robust genetic oscillators  [通常講演]
    Yasuaki Kobayashi, Tatsuo Shibata, Yoshiki Kuramoto, Alexander S. Mikhailov
    Strukturbildung in Chemie und Biophysik, Hotel Niedersachsen, Goslar, Germany 2011年02月
  • Evolutionary design of robust oscillatory genetic networks  [通常講演]
    Yasuaki Kobayashi, Tatsuo Shibata, Yoshiki Kuramoto, Alexander S. Mikhailov
    Halbj ̈ahrliches Netzwerk-Treffen Berlin-Dresden-G ̈ottingen-Leipzig, Max Planck Institute for Mathematics in the Sciences, Leipzig, Germany 2010年11月
  • Evolutionary design of oscillatory genetic networks  [通常講演]
    Yasuaki Kobayashi, Tatsuo Shibata, Yoshiki Kuramoto, Alexander S. Mikhailov
    Noise in Life 2010, Centro de Ciencias de Benasque Pedro Pascual, Benasque, Spain 2010年10月
  • Evolutionary design and statistical analysis of oscillatory genetic networks  [通常講演]
    Yasuaki Kobayashi, Tatsuo Shibata, Yoshiki Kuramoto, Alexander S. Mikhailov
    Multi-scale Dynamics and Evolvability of Biological Networks, Max Planck Insti- tute for Mathematics in the Sciences, Leipzig, Germany 2010年10月
  • Evolutionary design of oscillatory genetic networks  [通常講演]
    Yasuaki Kobayashi, Tatsuo Shibata, Yoshiki Kuramoto, Alexander S. Mikhailov
    ROBUST Conference, the University of Balearic Islands, Parma de Mallorca, Spain 2010年09月
  • Evolutionary design of oscillatory genetic networks  [通常講演]
    Yasuaki Kobayashi, Tatsuo Shibata, Yoshiki Kuramoto, Alexander S. Mikhailov
    Emerging Topics in Nonlinear Science,” Goldrain Castle, Goldrain, Italy 2010年09月
  • Evolutionary design of oscillatory genetic networks  [通常講演]
    Yasuaki Kobayashi, Tatsuo Shibata, Yoshiki Kuramoto, Alexander S. Mikhailov
    Strukturbildung in Chemie und Biophysik, Hotel Niedersachsen, Goslar, Germany 2010年02月
  • Evolutionary design and statistical analysis of oscillatory genetic networks  [通常講演]
    Yasuaki Kobayashi, Tatsuo Shibata, Yoshiki Kuramoto, Alexander S. Mikhailov
    Frontiers in Network Science, Fritz Haber Institute of the Max Planck Society, Berlin, Germany 2009年09月

その他活動・業績

  • ノイズのある結合振動子系の位相スリップ
    小林康明 数理解析研究所講究録 2063 1 -6 2018年 [査読無し][通常論文]
  • 角層バリア機能の数理モデルとその応用
    長山雅晴, 傳田光洋, 北畑裕之, 小林康明 応用数理 27 66 -74 2017年 [査読無し][通常論文]
  • 皮膚疾患再現を目指した皮膚構造数理モデル
    長山雅晴, 小林康明, 安ヶ平裕介, 熊本淳一, 傳田光洋, 北畑裕之, 中田聡 計算工学講演会論文集 22 2017年 [査読無し][通常論文]
  • 真皮変形を伴う表 皮構造の数理モデリング
    長山雅晴, 小林康明, 熊本淳一, 傳田光洋, 中田聡, 北畑裕之 計算工学講演会論文集 21 2016年 [査読無し][通常論文]
  • 表皮構造の数理モデリング
    長山雅晴, 小林康明, 熊本淳一, 澤武裕輔, 傳田光洋, 中田聡, 北畑裕之 マス・フォア・インダストリー研究 3 17 -25 2015年 [査読無し][通常論文]
  • 真皮形状を考慮した皮膚構造の数理モデリング
    長山雅晴, 小林康明, 澤武裕輔, 久保実沙貴, 傳田光洋, 北畑裕之, 中田聡 計算工学講演会論文集 20 2015年 [査読無し][通常論文]
  • 表皮の連続体モデルによる真皮形状と角層形状についての解析
    小林康明, 北畑裕之, 長山雅晴 計算工学講演会論文集 20 2015年 [査読無し][通常論文]
  • 表皮構造の数理モデル
    長山雅晴, 小林康明, 澤武祐輔, 久保実沙貴, 傳田光洋, 中田聡, 北畑裕之 数理解析研究所講究録 1957 155 -168 2015年 [査読無し][通常論文]
  • 樟脳円盤の集団運動に 対する計算機援用解析
    長山雅晴, 若井健, 小林康明, 西慧, 井倉 S. 弓彦, 中田聡 計算工学講演会論文集 19 2014年 [査読無し][通常論文]
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教育活動情報

主要な担当授業

  • 線形代数学Ⅰ
    開講年度 : 2020年
    課程区分 : 学士課程
    開講学部 : 全学教育
    キーワード : 数理モデリング、微分方程式、非線形科学,分岐理論
  • 線形代数学Ⅱ
    開講年度 : 2020年
    課程区分 : 学士課程
    開講学部 : 全学教育
    キーワード : ベクトル空間, 線形写像, 線形独立, 基底, 固有値, 固有ベクトル, 対角化
  • 数学総合講義Ⅰ
    開講年度 : 2020年
    課程区分 : 学士課程
    開講学部 : 理学部
    キーワード : 数理モデリング、微分方程式、非線形科学,分岐理論
  • 数理科学演習
    開講年度 : 2020年
    課程区分 : 学士課程
    開講学部 : 理学部
    キーワード : 数値解析・数値計算・シミュレーション・プログラミング・C言語


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