MF研究者総覧

研究者データベース

詳細
越川　滋行(コシカワ　シゲユキ)
地球環境科学研究院　環境生物科学部門　生態遺伝学分野
教授
researchmap個人ページ
Last Updated :2023/12/05

基本情報

所属

  • 地球環境科学研究院　環境生物科学部門　生態遺伝学分野

職名

  • 教授

学位

  • 博士（理学）（2005年03月 東京大学）

ホームページURL

J-Global ID

研究キーワード

  • 自然史   エボデボ   シロアリ   ショウジョウバエ   

研究分野

  • 環境・農学 / 昆虫科学
  • ライフサイエンス / 生態学、環境学
  • ライフサイエンス / 進化生物学
  • ライフサイエンス / 発生生物学

担当教育組織

職歴

  • 2023年04月 - 現在 北海道大学 大学院地球環境科学研究院 環境生物科学部門 部門長
  • 2023年04月 - 現在 北海道大学 高等教育推進機構 全学教育部 自然科学実験支援室長
  • 2022年04月 - 現在 北海道大学 大学院地球環境科学研究院 教授
  • 2018年04月 - 現在 北海道大学 理学部 兼務
  • 2017年09月 - 現在 北海道大学 大学院 環境科学院 担当
  • 2017年09月 - 2022年03月 北海道大学 大学院 地球環境科学研究院 准教授
  • 2018年04月 - 2020年03月 北海道大学 高等教育推進機構 兼務
  • 2014年04月 - 2017年08月 京都大学 大学院理学研究科 生物科学専攻 生物物理学教室 連携助教
  • 2014年04月 - 2017年08月 京都大学 白眉センター 特定助教
  • 2010年04月 - 2014年03月 ハワード・ヒューズ医学研究所 専門研究員
  • 2008年04月 - 2010年03月 日本学術振興会 海外特別研究員
  • 2005年04月 - 2008年03月 日本学術振興会 特別研究員（PD）
  • 2002年04月 - 2005年03月 日本学術振興会 特別研究員（DC1）

学歴

  • 2000年04月 - 2005年03月   東京大学大学院   理学系研究科   生物科学専攻
  • 1996年04月 - 2000年03月   東京都立大学   理学部   生物学科

所属学協会

  • 日本発生生物学会   日本応用動物昆虫学会   日本生態学会   日本動物学会   日本昆虫学会   日本進化学会   

研究活動情報

論文

  • Takuma Niida, Yuto Terashima, Hitoshi Aonuma, Shigeyuki Koshikawa
    Zoological Letters 9 9  2023年05月12日 [査読有り][通常論文]
  • Yuichi Fukutomi, Aya Takahashi, Shigeyuki Koshikawa
    Development Genes and Evolution in press  2023年 [査読有り][通常論文]
  • Takumi Karasawa, Namoho Saito, Shigeyuki Koshikawa
    FEBS Letters in press  2023年 [査読有り][通常論文]
  • ショウジョウバエの翅の模様形成メカニズムとその進化
    柄澤匠, 越川滋行
    科学 92 11 992 - 996 2022年11月01日 [査読無し][招待有り]
  • 昆虫の翅模様の進化発生生物学
    古関将斗, 越川滋行
    生体の科学 73 4 364 - 367 公益財団法人金原一郎記念医学医療振興財団／医学書院 2022年08月15日 [査読無し][招待有り]
  • Yoshinobu Hayashi, Kohei Oguchi, Mayuko Nakamura, Shigeyuki Koshikawa, Toru Miura
    Genes & Genetic Systems 2022年06月01日 [査読有り][通常論文]
  • Ryo Futahashi, Shigeyuki Koshikawa, Genta Okude, Mizuko Osanai-Futahashi
    Advances in Insect Physiology 62 339 - 376 2022年04月18日 [査読有り][招待有り]
  • Kohei Oguchi, Shigeyuki Koshikawa, Toru Miura
    Developmental Biology 485 70 - 79 2022年03月04日 [査読有り][通常論文]
  • Cédric Finet, Victoria A Kassner, Antonio B Carvalho, Henry Chung, Jonathan P Day, Stephanie Day, Emily K Delaney, Francine C De Ré, Héloïse D Dufour, Eduardo Dupim, Hiroyuki F Izumitani, Thaísa B Gautério, Jessa Justen, Toru Katoh, Artyom Kopp, Shigeyuki Koshikawa, Ben Longdon, Elgion L Loreto, Maria D S Nunes, Komal K B Raja, Mark Rebeiz, Michael G Ritchie, Gayane Saakyan, Tanya Sneddon, Machiko Teramoto, Venera Tyukmaeva, Thyago Vanderlinde, Emily E Wey, Thomas Werner, Thomas M Williams, Lizandra J Robe, Masanori J Toda, Ferdinand Marlétaz
    Genome Biology and Evolution evab179  2021年08月03日 [査読有り][通常論文]
     
    Abstract The vinegar fly Drosophila melanogaster is a pivotal model for invertebrate development, genetics, physiology, neuroscience, and disease. The whole family Drosophilidae, which contains over 4,400 species, offers a plethora of cases for comparative and evolutionary studies. Despite a long history of phylogenetic inference, many relationships remain unresolved among the genera, subgenera and species groups in the Drosophilidae. To clarify these relationships, we first developed a set of new genomic markers and assembled a multilocus dataset of 17 genes from 704 species of Drosophilidae. We then inferred a species tree with highly supported groups for this family. Additionally, we were able to determine the phylogenetic position of some previously unplaced species. These results establish a new framework for investigating the evolution of traits in fruit flies, as well as valuable resources for systematics.
  • Yuichi Fukutomi, Shigeyuki Koshikawa
    Pigments, Pigment Cells and Pigment Patterns 367 - 384 2021年07月06日 [査読有り][招待有り]
  • Yuichi Fukutomi, Shu Kondo, Atsushi Toyoda, Shuji Shigenobu, Shigeyuki Koshikawa
    The FEBS journal 288 1 115 - 126 2021年01月04日 [査読有り][通常論文]
     
    How evolutionary novelties have arisen is one of the central questions in evolutionary biology. Pre-existing gene regulatory networks or signaling pathways have been shown to be co-opted for building novel traits in several organisms. However, the structure of entire gene regulatory networks and evolutionary events of gene co-option for emergence of a novel trait are poorly understood. In this study, to explore the genetic and molecular bases of the novel wing pigmentation pattern of a polka-dotted fruit fly (Drosophila guttifera), we performed de novo genome sequencing and transcriptome analyses. As a result, we comprehensively identified the genes associated with the pigmentation pattern. Furthermore, we revealed that 151 of these associated genes were positively or negatively regulated by wingless, a master regulator of wing pigmentation. Genes for neural development, Wnt signaling, Dpp signaling, and effectors (such as enzymes) for melanin pigmentation were included among these 151 genes. None of the known regulatory genes that regulate pigmentation pattern formation in other fruit fly species were included. Our results suggest that the novel pigmentation pattern of the polka-dotted fruit fly might have emerged through multi-step co-options of multiple gene regulatory networks, signaling pathways, and effector genes, rather than recruitment of one large gene circuit.
  • Takuma Niida, Shigeyuki Koshikawa
    Ethology 127 7 527 - 536 2021年 [査読有り][通常論文]
  • Masato Koseki, Nobuaki K. Tanaka, Shigeyuki Koshikawa
    Development Genes and Evolution 231 85 - 93 2021年 [査読有り][通常論文]
  • Takayuki Suzuki, Shigeyuki Koshikawa
    Development, Growth & Differentiation 62 5 263 - 264 2020年06月 [査読無し][招待有り]
  • Héloïse D. Dufour, Shigeyuki Koshikawa, Cédric Finet
    Proceedings of the National Academy of Sciences of the United States of America 117 21 11589 - 11596 2020年05月11日 [査読有り][通常論文]
     
    共同責任著者
  • Mujeeb Shittu, Tessa Steenwinkel, Shigeyuki Koshikawa, Thomas Werner
    Methods and Protocols 3 31  2020年04月27日 [査読有り][通常論文]
  • Shigeyuki Koshikawa
    Development, Growth & Differentiation 62 5 269 - 278 2020年03月14日 [査読有り][招待有り]
  • Miura T, Oguchi K, Nakamura M, Jimi N, Miura S, Hayashi Y, Koshikawa S, Aguado MT
    Zoological Science 36 5 372 - 379 2019年10月 [査読有り][通常論文]
  • 丹伊田拓磨, 越川滋行
    昆虫と自然 54 7 36 - 39 2019年07月 [査読無し][招待有り]
     
    In Japanese
  • Nii R, Oguchi K, Shinji J, Koshikawa S, Miura T
    EvoDevo 10 10  2019年05月 [査読有り][通常論文]
  • Sugime Y, Oguchi K, Gotoh H, Hayashi Y, Matsunami M, Shigenobu S, Koshikawa S, Miura T
    Development 146 5 dev171942  2019年03月 [査読有り][通常論文]
  • Suzuki TK, Koshikawa S, Kobayashi I, Uchino K, Sezutsu H
    Insect Molecular Biology 28 4 568 - 577 2019年02月 [査読有り][通常論文]
  • 福冨雄一, 越川滋行
    蚕糸・昆虫バイオテック 87 2 95 - 102 2018年08月 [査読無し][招待有り]
     
    In Japanese
  • Fukutomi Y, Matsumoto K, Funayama N, Koshikawa S
    Journal of Visualized Experiments 131 e56935  2018年01月 [査読有り][招待有り]
  • Koshikawa S, Fukutomi Y, Matsumoto K
    Diversity and Evolution of Butterfly Wing Patterns: An Integrative Approach 287 - 301 2017年09月 [査読有り][招待有り]
  • Yuichi Fukutomi, Keiji Matsumoto, Kiyokazu Agata, Noriko Funayama, Shigeyuki Koshikawa
    DEVELOPMENT GENES AND EVOLUTION 227 3 171 - 180 2017年06月 [査読有り][通常論文]
     
    Various organisms have color patterns on their body surfaces, and these color patterns are thought to contribute to physiological regulation, communication with conspecifics, and signaling with the environment. An adult fly of Drosophila guttifera (Insecta: Diptera: Drosophilidae) has melanin pigmentation patterns on its body and wings. Though D. guttifera has been used for research into color pattern formation, how its pupal development proceeds and when the pigmentation starts have not been well studied. In this study, we defined the pupal stages of D. guttifera and measured the pigment content of wing spots from the pupal period to the period after eclosion. Using a transgenic line which carries eGFP connected with an enhancer of yellow, a gene necessary for melanin synthesis, we analyzed the timing at which the yellow enhancer starts to drive eGFP. We also analyzed the distribution of Yellow-producing cells, as indicated by the expression of eGFP during pupal and young adult periods. The results suggested that Yellow-producing cells were removed from wings within 3 h after eclosion, and wing pigmentation continued without epithelial cells. Furthermore, the results of vein cutting experiments showed that the transport of melanin precursors through veins was necessary for wing pigmentation. These results showed the importance of melanin precursors transported through veins and of extracellular factors which were secreted from epithelial cells and left in the cuticle.
  • Takuma Hashimoto, Daiki D. Horikawa, Yuki Saito, Hirokazu Kuwahara, Hiroko Kozuka-Hata, Tadasu Shin-, Yohei Minakuchi, Kazuko Ohishi, Ayuko Motoyama, Tomoyuki Aizu, Atsushi Enomoto, Koyuki Kondo, Sae Tanaka, Yuichiro Hara, Shigeyuki Koshikawa, Hiroshi Sagara, Toru Miura, Shin-ichi Yokobori, Kiyoshi Miyagawa, Yutaka Suzuki, Takeo Kubo, Masaaki Oyama, Yuji Kohara, Asao Fujiyama, Kazuharu Arakawa, Toshiaki Katayama, Atsushi Toyoda, Takekazu Kunieda
    NATURE COMMUNICATIONS 7 12808  2016年09月 [査読有り][通常論文]
     
    Tardigrades, also known as water bears, are small aquatic animals. Some tardigrade species tolerate almost complete dehydration and exhibit extraordinary tolerance to various physical extremes in the dehydrated state. Here we determine a high-quality genome sequence of Ramazzottius varieornatus, one of the most stress-tolerant tardigrade species. Precise gene repertoire analyses reveal the presence of a small proportion (1.2% or less) of putative foreign genes, loss of gene pathways that promote stress damage, expansion of gene families related to ameliorating damage, and evolution and high expression of novel tardigrade-unique proteins. Minor changes in the gene expression profiles during dehydration and rehydration suggest constitutive expression of tolerance-related genes. Using human cultured cells, we demonstrate that a tardigrade-unique DNA-associating protein suppresses X-ray-induced DNA damage by similar to 40% and improves radiotolerance. These findings indicate the relevance of tardigrade-unique proteins to tolerability and tardigrades could be a bountiful source of new protection genes and mechanisms.
  • Hiroyuki F. Izumitani, Yohei Kusaka, Shigeyuki Koshikawa, Masanori J. Toda, Toru Katoh
    PLOS ONE 11 7 e0160051  2016年07月 [査読有り][通常論文]
     
    The current subgenus Drosophila (the traditional immigrans-tripunctata radiation) includes major elements of temperate drosophilid faunas in the northern hemisphere. Despite previous molecular phylogenetic analyses, the phylogeny of the subgenus Drosophila has not fully been resolved: the resulting trees have more or less varied in topology. One possible factor for such ambiguous results is taxon-sampling that has been biased towards New World species in previous studies. In this study, taxon sampling was balanced between Old and New World species, and phylogenetic relationships among 45 ingroup species selected from ten core species groups of the subgenus Drosophila were analyzed using nucleotide sequences of three nuclear and two mitochondrial genes. Based on the resulting phylogenetic tree, ancestral distributions and divergence times were estimated for each clade to test Throckmorton's hypothesis that there was a primary, early-Oligocene disjunction of tropical faunas and a subsequent mid-Miocene disjunction of temperate faunas between the Old and the New Worlds that occurred in parallel in separate lineages of the Drosophilidae. Our results substantially support Throckmorton's hypothesis of ancestral migrations via the Bering Land Bridge mainly from the Old to the New World, and subsequent vicariant divergence of descendants between the two Worlds occurred in parallel among different lineages of the subgenus Drosophila. However, our results also indicate that these events took place multiple times over a wider time range than Throckmorton proposed, from the late Oligocene to the Pliocene.
  • Yasuhiro Sugime, Kota Ogawa, Dai Watanabe, Hiroyuki Shimoji, Shigeyuki Koshikawa, Toru Miura
    SCIENCE OF NATURE 102 11-12 71  2015年12月 [査読有り][通常論文]
     
    In termites, the soldier caste possesses morphological features suitable for colony defence, despite some exceptions. Soldiers are differentiated via two moultings through a presoldier stage with dramatic morphogenesis. While a number of morphological modifications are known to occur during the presoldier moult, growth and morphogenesis seem to continue even after the moult. The present study, using the damp-wood termite Hodotermopsis sjostedti, carried out morphological and histological investigations on the developmental processes during the presoldier stage that is artificially induced by the application of a juvenile hormone analogue. Measurements of five body parameters indicated that head length significantly increased during the 14-day period after the presoldier moult, while it did not increase subsequently to the stationary moult (pseudergate moult as control). Histological observations also showed that the cuticular development played a role in the presoldier head elongation, suggesting that the soft and flexible presoldier cuticle contributed to the soldier morphogenesis in termites.
  • Shigeyuki Koshikawa
    FLY 9 4 155 - 159 2015年10月 [査読有り][招待有り]
     
    Animals have modular cis-regulatory regions in their genomes, and expression of a single gene is often regulated by multiple enhancers residing in such a region. In the laboratory, and also in natural populations, loss of an enhancer can result in a loss of gene expression. Although only a few examples have been well characterized to date, some studies have suggested that an evolutionary gain of a new enhancer function can establish a new gene expression domain. Our recent study showed that Drosophila guttifera has more enhancers and additional expression domains of the wingless gene during the pupal stage, compared to D. melanogaster, and that these new features appear to have evolved in the ancestral lineage leading to D. guttifera.(1) Gain of a new expression domain of a developmental regulatory gene (toolkit gene), such as wingless, can cause co-option of the expression of its downstream genes to the new domain, resulting in duplication of a preexisting structure at this new body position. Recently, with the advancement of evodevo studies, we have learned that the developmental regulatory systems are strikingly similar across various animal taxa, in spite of the great diversity of the animals' morphology. Even behind "new" traits, cooptions of essential developmental genes from known systems are very common. We previously provided concrete evidence of gains of enhancer activities of a developmental regulatory gene underlying gains of new traits.(1) Broad occurrence of this scenario is testable and should be validated in the future.
  • Shigeyuki Koshikawa, Matt W. Giorgianni, Kathy Vaccaro, Victoria A. Kassner, John H. Yoder, Thomas Werner, Sean B. Carroll
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112 24 7524 - 7529 2015年06月 [査読有り][通常論文]
     
    Changes in gene expression during animal development are largely responsible for the evolution of morphological diversity. However, the genetic and molecular mechanisms responsible for the origins of new gene-expression domains have been difficult to elucidate. Here, we sought to identify molecular events underlying the origins of three novel features of wingless (wg) gene expression that are associated with distinct pigmentation patterns in Drosophila guttifera. We compared the activity of cis-regulatory sequences (enhancers) across the wg locus in D. guttifera and Drosophila melanogaster and found strong functional conservation among the enhancers that control similar patterns of wg expression in larval imaginal discs that are essential for appendage development. For pupal tissues, however, we found three novel wg enhancer activities in D. guttifera associated with novel domains of wg expression, including two enhancers located surprisingly far away in an intron of the distant Wnt10 gene. Detailed analysis of one enhancer (the vein-tip enhancer) revealed that it overlapped with a region controlling wg expression in wing crossveins (crossvein enhancer) in D. guttifera and other species. Our results indicate that one novel domain of wg expression in D. guttifera wings evolved by co-opting pre-existing regulatory sequences governing gene activity in the developing wing. We suggest that the modification of existing enhancers is a common path to the evolution of new gene-expression domains and enhancers.
  • Satoshi Miyazaki, Yasukazu Okada, Hitoshi Miyakawa, Gaku Tokuda, Richard Cornette, Shigeyuki Koshikawa, Kiyoto Maekawa, Toru Miura
    PloS one 9 3 e92875  2014年 [査読有り][通常論文]
     
    Most hymenopteran species exhibit conspicuous sexual dimorphism due to ecological differences between the sexes. As hymenopteran genomes, under the haplodiploid genetic system, exhibit quantitative differences between sexes while remaining qualitatively identical, sexual phenotypes are assumed to be expressed through sex-specific gene usage. In the present study, the molecular basis for expression of sexual dimorphism in a queenless ant, Diacamma sp., which exhibits a distinct color dimorphism, was examined. Worker females of the species appear bluish-black, while winged males exhibit a yellowish-brown body color. Initially, observations of the pigmentation processes during pupal development revealed that black pigmentation was present in female pupae but not in males, suggesting that sex-specific melanin synthesis was responsible for the observed color dimorphism. Therefore, five orthologs of the genes involved in the insect melanin synthesis (yellow, ebony, tan, pale and dopa decarboxylase) were subcloned and their spatiotemporal expression patterns were examined using real-time quantitative RT-PCR. Of the genes examined, yellow, which plays a role in black melanin synthesis in insects, was expressed at higher levels in females than in males throughout the entire body during the pupal stage. RNA interference of yellow was then carried out in order to determine the gene function, and produced females with a more yellowish, brighter body color similar to that of males. It was concluded that transcriptional regulation of yellow was responsible for the sexual color dimorphism observed in this species.
  • Akiko Hattori, Yasuhiro Sugime, Chifune Sasa, Hitoshi Miyakawa, Yuki Ishikawa, Satoshi Miyazaki, Yasukazu Okada, Richard Cornette, Laura Corley Lavine, Douglas J Emlen, Shigeyuki Koshikawa, Toru Miura
    Journal of experimental zoology. Part B, Molecular and developmental evolution 320 5 295 - 306 2013年07月 [査読有り][通常論文]
     
    Eusocial insects exhibit various morphological castes associated with the division of labor within a colony. Termite soldiers possess defensive traits including mandibles that are greatly exaggerated and enlarged, as compared to termite reproductives and workers. The enlarged mandibles of soldiers are known to result from dynamic morphogenesis during soldier differentiation that can be induced by juvenile hormone and its analogs. However, the detailed developmental mechanisms still remain unresolved. Because the insulin/insulin-like growth factor signaling (IIS) pathway has been shown to regulate the relative sizes of organs (i.e., allometry) in other insects, we examined the expression profiles of major IIS factors in the damp-wood termite Hodotermopsis sjostedti, during soldier differentiation. The relative expression patterns of orthologs for termite InR (HsjInR), PKB/Akt (HsjPKB/Akt), and FOXO (HsjFOXO) suggest that HsjInR and HsjPKB/Akt were up-regulated in the period of elongation of mandibles during soldier development. In situ hybridization showed that HsjInR was strongly expressed in the mandibular epithelial tissues, and RNA interference (RNAi) for HsjInR disrupted soldier-specific morphogenesis including mandibular elongation. These results suggest that signaling through the IIS pathway is required for soldier-specific morphogenesis. In addition, up-regulation of the IIS pathway in other body tissues occurred at earlier stages of development, indicating that there is tissue-specific IIS regulation. Because the IIS pathway is generally thought to act upstream of JH in insects, our results suggest the damp-wood termite may have evolved a novel feedback loop between JH and IIS that enables social interactions, rather than nutrition, to regulate caste determination.
  • Richard Cornette, Yoshinobu Hayashi, Shigeyuki Koshikawa, Toru Miura
    JOURNAL OF INSECT PHYSIOLOGY 59 4 509 - 518 2013年04月 [査読有り][通常論文]
     
    Termite societies are characterized by a highly organized division of labor among conspicuous castes, groups of individuals with various morphological specializations. Termite caste differentiation is under control of juvenile hormone OH), but the molecular mechanism underlying the response to JH and early events triggering caste differentiation are still poorly understood. In order to profile candidate gene expression during early soldier caste differentiation of the damp-wood termite, Hodotermopsis sjostedti, we treated pseudergates (workers) with a juvenile hormone analog (JHA) to induce soldier caste differentiation. We then used Suppressive Subtractive Hybridization to create two cDNA libraries enriched for transcripts that were either up- or downregulated at 24 h after treatment. Finally, we used quantitative PCR to confirm temporal expression patterns. Hexamerins represent a large proportion of the genes upregulated following JHA treatment and have an expression pattern that shows roughly an inverse correlation to intrinsic JH titers. This data is consistent with the role of a JH "sink", which was demonstrated for hexamerins in another termite, Reticulitermes flavipes. A putative nuclear protein was also upregulated a few hours after JHA treatment, which suggests a role in the early response to JH and subsequent regulation of transcriptional events associated with soldier caste differentiation. Some digestive enzymes, such as endogenous beta-endoglucanase and chymotrypsin, as well as a protein associated to digestion were identified among genes downregulated after JHA treatment. This suggests that JH may directly influence the pseudergate-specific digestive system. (c) 2013 Elsevier Ltd. All rights reserved.
  • Asano Ishikawa, Yuki Ishikawa, Yasukazu Okada, Satoshi Miyazaki, Hitoshi Miyakawa, Shigeyuki Koshikawa, Jennifer A Brisson, Toru Miura
    Journal of experimental zoology. Part A, Ecological genetics and physiology 317 3 194 - 203 2012年03月 [査読有り][通常論文]
     
    Aphids exhibit several polyphenisms in which discontinuous, alternative phenotypes are produced depending on environmental conditions. One representative example is the wing polyphenism, where winged and wingless females are produced through parthenogenesis. Previous work has shown that, in some aphid species, the density condition sensed by the mother aphid determines the developmental fate of embryos in her ovary, with high densities leading to winged progeny and low densities to wingless progeny. However, little is known about the molecular and physiological mechanisms underlying the wing polyphenism. To identify genes involved in the wing-morph determination in the vetch aphid, Megoura crassicauda, we compared maternal and embryonic transcripts between high- and low-density conditions using differential display, followed by quantitative real-time PCR (qRT-PCR). Under the high-density condition, two genes (Uba1 and Naca) were found to be upregulated in maternal tissues without ovaries, while one gene (ClpP) was upregulated in ovaries containing embryos. Uba1 and Naca encode factors that function in protein modification or transcriptional/translational regulation, respectively. In addition to differential display, candidate gene approaches focusing on morphogenetic and endocrine genes, i.e., wg, dpp, ap, hh, InR, IRS, Foxo, EcR, and USP, were also carried out. We found that wg was upregulated in maternal tissues under the high-density condition. The identified genes from both approaches are candidates for further study of their involvement in the transduction of density signals in mother aphids and/or the initial process of wing differentiation in embryos.
  • Hiroki Gotoh, Richard Cornette, Shigeyuki Koshikawa, Yasukazu Okada, Laura Corley Lavine, Douglas J. Emlen, Toru Miura
    PLOS ONE 6 6 e21139  2011年06月 [査読有り][通常論文]
     
    The morphological diversity of insects is one of the most striking phenomena in biology. Evolutionary modifications to the relative sizes of body parts, including the evolution of traits with exaggerated proportions, are responsible for a vast range of body forms. Remarkable examples of an insect trait with exaggerated proportions are the mandibular weapons of stag beetles. Male stag beetles possess extremely enlarged mandibles which they use in combat with rival males over females. As with other sexually selected traits, stag beetle mandibles vary widely in size among males, and this variable growth results from differential larval nutrition. However, the mechanisms responsible for coupling nutrition with growth of stag beetle mandibles (or indeed any insect structure) remain largely unknown. Here, we demonstrate that during the development of male stag beetles (Cyclommatus metallifer), juvenile hormone (JH) titers are correlated with the extreme growth of an exaggerated weapon of sexual selection. We then investigate the putative role of JH in the development of the nutritionally-dependent, phenotypically plastic mandibles, by increasing hemolymph titers of JH with application of the JH analog fenoxycarb during larval and prepupal developmental periods. Increased JH signaling during the early prepupal period increased the proportional size of body parts, and this was especially pronounced in male mandibles, enhancing the exaggerated size of this trait. The direction of this response is consistent with the measured JH titers during this same period. Combined, our results support a role for JH in the nutrition-dependent regulation of extreme mandible growth in this species. In addition, they illuminate mechanisms underlying the evolution of trait proportion, the most salient feature of the evolutionary diversification of the insects.
  • Yasukazu Okada, Satoshi Miyazaki, Shigeyuki Koshikawa, Richard Cornette, Kiyoto Maekawa, Kazuki Tsuji, Toru Miura
    Naturwissenschaften 97 11 971 - 9 2010年11月 [査読有り][通常論文]
     
    Of the various characteristics of social insects, communication for reproductive differentiation is one of the most important and basic social interactions among colony members. To elucidate the molecular basis underlying this process, genes responsible for reproductive differentiation in Diacamma were screened using fluorescent differential display. Differential display, together with real-time quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR), revealed that a gene belonging to the family of cellular retinaldehyde-binding proteins was specifically expressed in the epidermis of the head, legs, and thorax in reproductives. The deduced protein sequence in the coding region, obtained by rapid amplification of cDNA ends (RACE)-PCR, was found to include cellular retinaldehyde-binding domain (CRAL-TRIO domain), suggesting that DiaCRALDCP functions in transportation of lipids, such as cuticular hydrocarbons. DiaCRALDCP transcript levels immediately decreased 1 day after the gemma mutilation, suggesting that DiaCRALDCP is involved in the physiological changes provoked by the behavioral regulation. Considering these results, the social functions of DiaCRALDCP in Diacamma are discussed.
  • 越川滋行
    生物科学 62 1 19 - 29 2010年09月 [査読有り][招待有り]
     
    In Japanese
  • Shigeyuki Koshikawa, Richard Cornette, Tadao Matsumoto, Toru Miura
    BMC DEVELOPMENTAL BIOLOGY 10 63  2010年06月 [査読有り][通常論文]
     
    Background: Caste differentiation in social insects is a type of polyphenism that enables division of labor among members of a colony. This elaborate social integration has attracted broad interest, although little is known about its regulatory mechanisms, especially in Isoptera (termites). In this study, we analyzed soldier differentiation in the damp-wood termite Hodotermopsis sjostedti, focusing on a possible effector gene for caste development. The gene for an actin-binding protein, HsjCib, which shows a high level of expression in developing mandibles during soldier differentiation, is characterized in detail. Results: To examine the HsjCib gene, full-length cDNAs were obtained by rapid amplification of cDNA ends-polymerase chain reaction (RACE-PCR) and sequencing. Multiple isoforms were identified, and on the basis of the results of northern and Southern hybridization analyses, these isoforms were considered to be transcriptional variants from a single gene. On the basis of their sequence similarity to homologous genes of other organisms, functions in actin assembly were assumed to be different among isoforms. Expression analysis revealed high expression in the head during soldier differentiation, which was consistent with their allometric growth. Although isoform expression was observed in various tissues, different expression levels were observed among tissues, suggesting the possibility of tissue-specific morphogenetic regulation by HsjCib isoforms. Conclusion: This study revealed the characteristics and dynamics of the HsjCib gene during soldier differentiation as a potential representative of downstream effector genes in caste-specific morphogenesis. From the expression patterns observed, this gene is considered to be involved in cephalic morphogenesis and neural reorganization, resulting in the establishment of caste-specific morphology and behavior.
  • Yuki Ishikawa, Yasukazu Okada, Asano Ishikawa, Hitoshi Miyakawa, Shigeyuki Koshikawa, Toru Miura
    BMC genomics 11 314 - 314 2010年05月20日 [査読有り][通常論文]
     
    BACKGROUND: One of the key characters of social insects is the division of labor, in which different tasks are allocated to various castes. In termites, one of the representative groups of social insects, morphological differences as well as behavioral differences can be recognized among castes. However, very little is known about the neuronal and molecular bases of caste differentiation and caste-specific behavior. In almost all termite species, soldiers play defensive roles in their colonies, and their morphology and behavior are largely different from workers (or pseudergates). Therefore, we predicted that some genes linked to defensive behavior and/or those required for neuronal changes are differentially expressed between workers and soldiers, or during the soldier differentiation, respectively. RESULTS: Using the brain and suboesophageal ganglion (SOG) of the damp-wood termite Hodotermopsis sjostedti, we first screened genes specifically expressed in soldiers or during soldier differentiation by the differential display method, followed by quantitative real-time polymerase chain reaction. No distinctive differences in expression patterns were detected between pseudergates and soldiers. In the course of soldier differentiation, however, five genes were found to be up-regulated in brain and/or SOG: 14-3-3 epsilon, fibrillin2, beta-tubulin, ciboulot, and a hypothetical protein containing a SAP motif. Some of these genes are thought to be associated with cytoskeletal structure or motor-associated proteins in neuronal tissues. CONCLUSION: The identified five genes could be involved in soldier-specific neuronal modifications, resulting in defensive behaviors in termite soldiers. The temporal expression patterns of these genes were consistent with the neuronal changes during soldier differentiation, suggesting that molecular machineries, in which the identified factors would participate, play important roles in behavioral differentiation of termite soldiers.
  • Thomas Werner, Shigeyuki Koshikawa, Thomas M. Williams, Sean B. Carroll
    NATURE 464 7292 1143 - 1148 2010年04月 [査読有り][通常論文]
     
    The complex, geometric colour patterns of many animal bodies have important roles in behaviour and ecology. The generation of certain patterns has been the subject of considerable theoretical exploration, however, very little is known about the actual mechanisms underlying colour pattern formation or evolution. Here we have investigated the generation and evolution of the complex, spotted wing pattern of Drosophila guttifera. We show that wing spots are induced by the Wingless morphogen, which is expressed at many discrete sites that are specified by pre-existing positional information that governs the development of wing structures. Furthermore, we demonstrate that the elaborate spot pattern evolved from simpler schemes by co-option of Wingless expression at new sites. This example of a complex design developing and evolving by the layering of new patterns on pre-patterns is likely to be a general theme in other animals.
  • Hitoshi Miyakawa, Maki Imai, Naoki Sugimoto, Yuki Ishikawa, Asano Ishikawa, Hidehiko Ishigaki, Yasukazu Okada, Satoshi Miyazaki, Shigeyuki Koshikawa, Richard Cornette, Toru Miura
    BMC DEVELOPMENTAL BIOLOGY 10 45  2010年04月 [査読有り][通常論文]
     
    Background: Numerous cases of predator-induced polyphenisms, in which alternate phenotypes are produced in response to extrinsic stimuli, have been reported in aquatic taxa to date. The genus Daphnia (Branchiopoda, Cladocera) provides a model experimental system for the study of the developmental mechanisms and evolutionary processes associated with predator-induced polyphenisms. In D. pulex, juveniles form neckteeth in response to predatory kairomones released by Chaoborus larvae (Insecta, Diptera).Results: Previous studies suggest that the timing of the sensitivity to kairomones in D. pulex can generally be divided into the embryonic and postembryonic developmental periods. We therefore examined which of the genes in the embryonic and first-instar juvenile stages exhibit different expression levels in the presence or absence of predator kairomones. Employing a candidate gene approach and identifying differentially-expressed genes revealed that the morphogenetic factors, Hox3, extradenticle and escargot, were up-regulated by kairomones in the postembryonic stage and may potentially be responsible for defense morph formation. In addition, the juvenile hormone pathway genes, JHAMT and Met, and the insulin signaling pathway genes, InR and IRS-1, were up-regulated in the first-instar stage. It is well known that these hormonal pathways are involved in physiological regulation following morphogenesis in many insect species. During the embryonic stage when morphotypes were determined, one of the novel genes identified by differential display was up-regulated, suggesting that this gene may be related to morphotype determination. Biological functions of the up-regulated genes are discussed in the context of defense morph formation.Conclusions: It is suggested that, following the reception of kairomone signals, the identified genes are involved in a series of defensive phenotypic alterations and the production of a defensive phenotype.
  • A. Nakabachi, S. Koshikawa, T. Miura, S. Miyagishima
    BULLETIN OF ENTOMOLOGICAL RESEARCH 100 1 27 - 33 2010年02月 [査読有り][通常論文]
     
    Psyllids harbor the primary symbiont, Carsonella ruddii (gamma-Proteobacteria), within the cytoplasm of specialized cells called bacteriocytes. Carsonella has the smallest known cellular genome (160kb), lacking numerous genes that appear to be essential for bacterial life. This raises the question regarding the genetic mechanisms of the host which supports the survival of Carsonella. Our preceding analyses have indicated that some of the genes that are encoded in the psyllid genome and which are highly expressed in the bacteriocyte are of bacterial origin. This implies that psyllids acquired genes from bacteria by lateral gene transfer (LGT) and are using these genes to maintain the primary symbiont, Carsonella. To reveal the complete Picture of LGT from symbiotic bacteria to the genome of psyllids, whole genome analysis of psyllid is essential. In order to assess the feasibility of whole genome analysis of the host psyllid, the genome size of the hackberry petiole gall psyllid, Pachypsylla venusta, was estimated. Feulgen image analysis densitometry and flow cytometry demonstrated that the haploid genome size of P. venusta is 0.74pg (724Mb), verifying the feasibility of whole genome analysis. Feulgen image analysis densitometry further revealed that bacteriocytes of P. venusta are invariably 16-ploid. This higher ploidy may be essential to facilitate the symbiotic relationship with bacteria, as it appears to be a feature common to insect bacteriocytes. These results provide a foundation for genomics-based research into host-symbiont interactions.
  • Cornette R, Koshikawa S, Miura T
    Insectes Sociaux 55 4 407 - 416 2008年09月 [査読有り][通常論文]
  • Shigeyuki Koshikawa, Satoshi Miyazaki, Richard Cornette, Tadao Matsumoto, Toru Miura
    NATURWISSENSCHAFTEN 95 9 859 - 867 2008年09月 [査読有り][通常論文]
     
    The evolution of genome size has been discussed in relation to the evolution of various biological traits. In the present study, the genome sizes of 22 dictyopteran species were estimated by Feulgen image analysis densitometry and 6-diamidino-2-phenylindole (DAPI)-based flow cytometry. The haploid genome sizes (C-values) of termites (Isoptera) ranged from 0.58 to 1.90 pg, and those of Cryptocercus wood roaches (Cryptocercidae) were 1.16 to 1.32 pg. Compared to known values of other cockroaches (Blattaria) and mantids (Mantodea), these values are low. A relatively small genome size appears to be a (syn)apomorphy of Isoptera + Cryptocercus, together with their sociality. In some phylogenetic groups, genome size evolution is thought to be influenced by selective pressure on a particular trait, such as cell size or rate of development. The present results raise the possibility that genome size is influenced by selective pressures on traits associated with the evolution of sociality.
  • Kiyoto Maekawa, Sayaka Mizuno, Shigeyuki Koshikawa, Toru Miura
    ZOOLOGICAL SCIENCE 25 7 699 - 705 2008年07月 [査読有り][通常論文]
     
    We morphologically examined postembryonic compound eye development in Reticulitermes speratus (Kolbe) to understand developmental regulation during caste differentiation. The eye primordia were shown to exist from the larval stage. The number of ommatidia and compound eye size greatly increased over the course of imaginal development. Nymphoids (second-form reproductives) possessed a developed compound eye structure on the surface of the cuticle and thick optic nerves, but individual ommatidia were not clearly discriminated. However, in the line of apterous workers and soldiers, although the outer rim of the eye was observed from second-stage workers, there were few morphological differences among instars, including ergatoids (third-form reproductives). Both nymphoids and ergatoids are slightly physogastric and have highly developed reproductive organs. These results suggest that eye development in the apterous line could be strongly arrested and that there is a weak developmental correlation between the eyes and reproductive organs in R. speratus.
  • Richard Cornette, Hiroki Gotoh, Shigeyuki Koshikawa, Toru Miura
    JOURNAL OF INSECT PHYSIOLOGY 54 6 922 - 930 2008年06月 [査読有り][通常論文]
     
    Termites are social insects, presenting morphologically distinct castes, performing specific tasks in the colony. The developmental processes underlying caste differentiation are mainly controlled by juvenile hormone (JH). Although many fragmentary data support this fact, there was no comparative work on JH titers during the caste differentiation processes. In this study, JH titer variation was investigated using a liquid chromatography-mass spectrometry (LC-MS) quantification method in all castes of the Japanese damp-wood termite Hodotermopsis sjostedti, especially focusing on the soldier caste differentiation pathway, which was induced by treatment with a JH analog. Hemolymph JH titers fluctuated between 20 and 720 pg/mu l. A peak of JH was observed during molting events for the pseudergate stationary molt and presoldier differentiation, but this peak was absent prior to the imaginal molt. Soldier caste differentiation was generally associated with high JH titers and nymph to alate differentiation with low JH titers. However, JH titer rose in females during alate maturation, probably in relation to vitellogenesis. In comparison, JH titer was surprisingly low in neotenics. On the basis of these results in both natural and artificial conditions, the current model for JH action on termite caste differentiation is discussed and re-appraised. (C) 2008 Elsevier Ltd. All rights reserved.
  • Hiroki Gotoh, Richard Cornette, Shigeyuki Koshikawa, Toru Miura
    SOCIOBIOLOGY 52 2 345 - 356 2008年 [査読有り][通常論文]
     
    Juvenile hormone (JH) is an insect hormone that is responsible for the control of a variety of physiological and developmental states. In termites' JH has long been considered to play an important role in caste differentiation, although the detailed mechanisms underlying the actions of the hormone are not well understood. In this study, we applied three types of precocenes, anti-JH agents that destroy the corpora allata (CA), to pseudergates (workers) of the damp-wood termite Hodotermopsis sjostedti, and evaluated the effects on the CA volume and JH titer after the treatments. Results showed degeneration of the CA at day 14 in the precocene-II-treated group, which was not observed in the control group. Conversely, no significant difference in the JH titer was apparent between precocenc-II-treated groups and their corresponding controls. These results indicate that CA degeneration is not always correlated with a decrease in JH titer. Precocenes are thus not effective as anti-JH agents in the focal termite species. These findings indicate that simultaneous examination of JH titer and CA size are important considerations for evaluating the effects of anti-JH agents.
  • 越川滋行, 三浦徹
    日本生態学会誌 57 1 82 - 88 2007年03月 [査読有り][招待有り]
     
    In Japanese
  • Differences in mechanosensory hairs among castes of the damp-wood termite Hodotermopsis sjostedti (Isoptera: Termitidae)
    Ishikawa Y, Koshikawa S, Miura T
    Sociobiology 50 3 895 - 907 2007年 [査読有り][通常論文]
  • R Cornette, S Koshikawa, M Hojo, T Matsumoto, T Miura
    INSECT MOLECULAR BIOLOGY 15 2 235 - 244 2006年04月 [査読有り][通常論文]
     
    Termites are eusocial insects with a well-defined caste system, which is an example of polyphenism. This polyphenism is based on hormonally controlled differential gene expression. In the damp-wood termite Hodotermopsis sjostedti, we induced differentiation into the soldier caste by using juvenile hormone analogue treatment. We then investigated specific gene expression, which appeared during the hormonal response and triggered caste differentiation, using fluorescent differential display. A candidate cDNA sequence with similarity to cytochromes P450, CYP6AM1, was characterized and its transcript shown to be repressed between 1 and 3 days after hormone treatment. CYP6AM1 was specifically expressed in the fat body of pseudergates and soldiers. The putative function of this P450 is discussed with respect to the caste differentiation system.
  • HOJO Masaru, KOSHIKAWA Shigeyuki, CORNETTE Richard, MATSUMOTO Tadao, MIURA Toru
    Entomol Sci 8 4 379 - 387 2005年12月 [査読無し][通常論文]
  • 越川滋行, 松本忠夫, 三浦徹
    昆虫と自然 40 11 17 - 21 2005年11月 [査読無し][招待有り]
     
    In Japanese
  • オオシロアリHodotermopsis sjostedtiの兵隊分化に伴う形態形成と遺伝子発現に関する研究
    越川滋行
    東京大学大学院理学系研究科 2005年03月 [査読無し][通常論文]
     
    博理第4723号
  • S Koshikawa, R Cornette, M Hojo, K Maekawa, T Matsumoto, T Miura
    FEBS LETTERS 579 6 1365 - 1370 2005年02月 [査読有り][通常論文]
     
    We investigated the morphological changes accompanying soldier differentiation in the damp-wood termite Hodotermopsis sjostediti. Genes expressed in the developing mandibles, which undergo the most remarkable morphological changes during soldier differentiation, were screened using fluorescent differential display. Database searches for sequence similarities were conducted and the relative expression levels were then quantified by real-time polymerase chain reaction. Among the identified candidate genes, 12 genes were upregulated during soldier differentiation. These included genes for cuticle proteins, nucleic acid binding proteins, ribosomal proteins and actin-binding protein, which were inferred to be involved in caste-sped c morphogenesis in termites. (C) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
  • T Miura, S Koshikawa, M Machida, T Matsumoto
    INSECTES SOCIAUX 51 3 247 - 252 2004年08月 [査読有り][通常論文]
     
    Termite colonies are comprised of several types of castes that differentiate throughout postembryonic development. In termopsid termites (family Termopsidae), alates are normally differentiated from apterous instars by two nymphal instar stages and three moulting events. Here, we report that of the rotten-wood termite Hodotermopsis sjostedti. There is only a single nymphal instar between the pseudergate and alate stages. During the annual alate production season in June/July, we observed some nymphs with small wing buds which were dorsally swollen. Those nymphal individuals subsequently moulted into alates through only a single moult. We examined their histology and internal morphology and observed that the folding pattern of the newly formed wings was very different from that seen in second stage nymphs of the closely related species Zootermopsis nevadensis. The newly formed wings of H. sjostedti are formed inside the relatively smaller wing buds and therefore must be folded in a complicated manner. Our observations revealed that the tips of the folded wings were elongated and bent, such that they overlapped in the median plane. We suggest that heterochronic evolutionary change accounts for the compression of nymphal development into a single instar. We also suggest that this probably occurred at either the individual or colony level in this species.
  • S Koshikawa, T Matsumoto, T Miura
    ZOOLOGICAL SCIENCE 21 5 583 - 588 2004年05月 [査読有り][通常論文]
     
    All termite species possess a distinct sterile-soldier caste in their colonies, although reproductive soldiers, with soldier characteristics and reproductive ability, have been reported from several species of the family Termopsidae. Such intercastes have been considered the primitive-soldier caste, and based on this many researchers have discussed the evolutionary origin of termite soldiers. We investigated whether such soldier-reproductive intercastes also exist in the Japanese rotten-wood termite Hodotermopsis sjostedti. Abnormal individuals with soldier-like characteristics were found and designated as soldier-like intercastes, which appeared to have both soldier and reproductive characteristics. Based on our morphometric analyses and histological examinations, we suggest that the developmental origin of this intercaste is a pseudergate, nymph or sixth-instar larva. In addition, the intercaste was found to have relatively well-developed gonads, although mature oocytes and spermatozoa were not found in female ovaries and male seminal vesicles, respectively. We conclude that the soldier-like intercaste of H. sjostedti does not have reproductive ability, which is different from all other known soldier-like intercastes in Termopsidae.
  • MU Hojo, S Koshikawa, T Matsumoto, T Miura
    SOCIOBIOLOGY 44 2 433 - 441 2004年 [査読有り][通常論文]
     
    Caste developmental pathways vary among termite species. We investigated the caste developmental patterns of Nasutitermes takasagoensis, based on morphometric data. These patterns appear to be identical to those of other Nasutitermes species. In addition, a nymph-presoldier intercaste was found during the study. We analyzed the detailed morphology of the intercaste and discuss the developmental plasticity of the caste differentiation in this nasute termite.
  • T Miura, S Koshikawa, T Matsumoto
    JOURNAL OF MORPHOLOGY 257 1 22 - 32 2003年07月 [査読有り][通常論文]
     
    To elucidate the switching mechanism of caste differentiation in termites and to examine the possible induction of soldier-reproductive intercastes experimentally, we investigated the effects of juvenile hormone on the morphologies of soldier caste by applying a juvenile hormone analog (JHA) to nymphs of the damp-wood termite Zootermopsis nevadensis (Isoptera : Termopsidae). JHA treatment for about 2 weeks induced a variety of intermediate castes, showing both alate and soldier morphological features. The principal component analysis (PCA) of those morphological characters showed that those intercastes were a deviation from the developmental line into alates to soldier differentiation, which is known to be triggered by juvenile hormone. Detailed morphological examination of the compound eyes, wing joint, and mandibles showed that those intercastes expressed soldier features, although they had started to develop alate characteristics. The morphology of the resultant intercastes seemed to be determined by the nymphal stage, at which JHA treatment was applied. The induced intercastes with exaggerated soldier-specific characteristics (e.g., mandibles) repressed alate-specific characteristics (e.g., wings), namely, the alate and soldier morphological characteristics in induced intercastes show opposite responses against the application of JHA. On the other hand, ovarian development was not suppressed by the JHA application, even in the soldier-like individuals. Naturally differentiated presoldiers also possessed developed ovarioles, although ovaries of mature soldiers were degenerated. Our results suggest that the juvenile hormone plays complicated roles in the expression of caste morphologies and ovarian development in termites. (C) 2003 Wiley-Liss, Inc.
  • S Koshikawa, T Matsumoto, T Miura
    NATURWISSENSCHAFTEN 90 4 180 - 184 2003年04月 [査読有り][通常論文]
     
    The conspicuous morphogenesis during termite soldier differentiation is one of the most remarkable examples of specialized caste development in social insects. To clarify the mechanism of morphological changes during soldier differentiation, mandibular morphogenesis prior to the presoldier moult was examined in the damp-wood termite Hodotermopsis sjoestedti. Using experimental induction of presoldier differentiation from pseudergates (7th or later instar larvae) by the application of juvenile hormone analogue (JHA), we compared mandibular morphogenesis in a presoldier moult (from pseudergate to presoldier) with that of a stationary moult (from pseudergate to pseudergate). Future presoldier mandibles were formed under the old mandibular cuticle of the pseudergates just prior to the presoldier moult. Multiple folds of both epidermis and new cuticle were observed in the developing mandible, and large concavities between teeth were formed on the mandibular surface. While in the stationary moult, the future mandibles were formed with a smooth surface. The process of the mandibular morphogenesis in soldier differentiation explains the allometry of soldier mandibles. The morphological differences in mouth parts between castes arise from a switching mechanism that triggers caste-specific mandibular epithelial growth during development.
  • 三浦徹, 越川滋行, 松本忠夫
    日本比較内分泌学会ニュース 104 14 - 18 2002年02月 [査読有り][招待有り]
     
    In Japanese
  • S Koshikawa, T Matsumoto, T Miura
    INSECTES SOCIAUX 49 3 245 - 250 2002年 [査読有り][通常論文]
     
    To clarify the allometric development of body parts accompanying soldier differentiation in termites, we measured 16 body parts of soldiers, presoldiers, pseudergates (workers), nymphs and larvae of the damp-wood termite Hodotermopsis japonica. Principal component analysis (PCA) was performed using these parameters, which revealed that differentiation into soldiers differed distinctly from development into adult (reproductive) individuals. In particular, the anterior body parts enlarged during development of soldiers. Similarly, elongation of the apical portion of both mandibles was noted during soldier differentiation. X-ray analysis of mandibles revealed sclerotization of the soldier mandibles after differentiation into terminal soldiers. These morphological changes during soldier differentiation are associated with changes in their roles within the colony. Through soldier differentiation, the morphology of this caste of termite becomes functionally suited for attacking predators, and unsuitable for feeding on wood using their mandibles. Based on these data, we suggest that there must be some morphogenetic factors leading caste specific morphology such as soldier mandibles.
  • S Koshikawa, T Matsumoto, T Miura
    SOCIOBIOLOGY 38 3A 495 - 500 2001年 [査読有り][通常論文]
     
    Regressive molts from nymphs to pseudergates were observed in Hodotermopsis japonica in experimental groups composed of nymphs alone. This is the first study of the genus Hodotermopsis, and the regressive molt in this species was unique for Termopsidae because wing bud biting prior to the regressive molt was not observed. The thoracic morphologies of pseudergates derived from nymphs were different from those of normal pseudergates: the posterior margin of the metanotum was trapezoidal. It was suggested that the regressive molt occasionally occurs in this species, and is one of the features caused by the flexibility of caste differentiation in termites.

書籍

  • 関村利朗, 藤原晴彦, 大瀧丈二, 監修, 関村 利朗, 藤原 晴彦, 大瀧 丈二 (担当:分担執筆範囲:16章)
    海游舎 2017年11月 (ISBN: 4905930596) 408
  • 森長 真一, 工藤 洋, 日本生態学会 (担当:分担執筆範囲:第17章 エボデボと新しい総合 越川 滋行)
    共立出版 2012年12月 (ISBN: 4320057406) 320 263-277
  • 吉村 剛, 板倉修司, 岩田隆太郎, 大村和香子, 杉尾幸司, 竹松葉子, 徳田 岳, 松浦健二, 三浦 徹, 吉村 剛, 板倉修司, 岩田隆太郎, 大村和香子, 杉尾幸司, 竹松葉子, 徳田 岳, 松浦健二, 三浦 徹, 玉本 奈々 (担当:分担執筆範囲:4章2部「カースト分化の際の形態形成機構」越川滋行)
    海青社 2012年12月 (ISBN: 4860992601) 472

講演・口頭発表等

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    Shigeyuki Koshikawa
    Joint Symposium of School of Science & WPI-ICReDD in Hokkaido University 2020年12月 口頭発表（招待・特別）
  • ハエの翅の模様が作られる仕組み  [通常講演]
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    北海道大学環境科学院EESセミナー 2019年12月 公開講演，セミナー，チュートリアル，講習，講義等
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    越川滋行
    北海道大学地球環境科学研究院 公開講座〈生物の「変化」：理由、メカニズム、そして影響〉 2019年09月 公開講演，セミナー，チュートリアル，講習，講義等
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    越川滋行
    岡山大学昆虫学土曜セミナー 第367回 2019年07月 口頭発表（招待・特別）
  • ミズタマショウジョウバエの模様形成の仕組み  [通常講演]
    越川滋行
    第4回北海道大学部局横断シンポジウム 2019年01月 口頭発表（招待・特別） 
    （口頭発表賞2位）
  • ミズタマショウジョウバエDrosophila guttiferaの模様ができる仕組みを調べ、機能を考える  [通常講演]
    越川滋行
    第5回生態進化発生コロキウム 2017年12月 口頭発表（一般）
  • ミズタマショウジョウバエの水玉模様には意味があるのか？  [通常講演]
    越川滋行, 松本圭司, 福冨雄一
    5分で自分をアピール！生態学ライトニングトーク＠東京 第64回日本生態学会大会 自由集会 2017年03月 口頭発表（一般）
  • Drosophila guttifera: a model system for understanding color pattern formation  [招待講演]
    越川滋行
    モデル動物研究会「ムシサカナの会＠金沢」 2016年10月 口頭発表（招待・特別）
  • ショウジョウバエの新しい模様はどのように生じたか  [招待講演]
    越川滋行
    遺伝研研究集会 分子進化学の現状と今後の展望 2016年08月 口頭発表（招待・特別）
  • 模様はどのようにしてつくられるのか：ミズタマショウジョウバエを例に  [招待講演]
    越川滋行
    京都大学総合博物館 企画展 虫を知りつくす 京都大学の挑戦 特別講演会シリーズ 昆虫アカデミア 2016年08月 公開講演，セミナー，チュートリアル，講習，講義等
  • ミズタマショウジョウバエの模様形成の仕組み  [招待講演]
    越川滋行
    昆虫デザイン研究会 家畜化過程の理解とポスト家畜化 2016年07月 口頭発表（招待・特別）
  • ミズタマショウジョウバエの模様が形成される仕組みと機能を考える  [通常講演]
    越川滋行
    Evo-Devo青年の会 2016年06月 ポスター発表
  • 模様ができる仕組みとその意味  [招待講演]
    越川滋行
    シンポジウム 自然を問う理系 人間を問う文系 研究の原点とは 2016年04月 公開講演，セミナー，チュートリアル，講習，講義等
  • Gain of cis-regulatory activities and evolution of novel traits in Drosophila  [招待講演]
    越川滋行
    果蝇进化遗传学术报告 华南农业大学 2015年10月 公開講演，セミナー，チュートリアル，講習，講義等
  • ショウジョウバエの模様形成と、動物の新しい形態の進化  [招待講演]
    越川滋行
    富山大学理学部生物学科セミナー 兼第25回北陸社会性昆虫勉強会 2015年03月 公開講演，セミナー，チュートリアル，講習，講義等
  • 研究者として生きる-新しい価値を生み出す苦しみと喜び  [招待講演]
    越川滋行
    佐高OB夢授業 千葉県立佐原高等学校 2014年12月 公開講演，セミナー，チュートリアル，講習，講義等
  • ミズタマショウジョウバエの模様の進化  [招待講演]
    越川滋行
    第262回 生態学研究センターセミナー 2014年12月 公開講演，セミナー，チュートリアル，講習，講義等
  • 生物学—動物の模様は何のためにあるのか？  [通常講演]
    越川滋行
    京都大学ジュニアキャンパス 2014年09月 公開講演，セミナー，チュートリアル，講習，講義等
  • 蝶の模様はどのようにつくられるのか？  [通常講演]
    越川滋行
    京都大学サマースクール 2014年08月 公開講演，セミナー，チュートリアル，講習，講義等
  • ミズタマショウジョウバエの模様形成 ー新しい発現パターンはどのように獲得されるのか  [招待講演]
    越川滋行
    名古屋大学IGERセミナー 2014年06月 公開講演，セミナー，チュートリアル，講習，講義等
  • 進化発生学の未来  [招待講演]
    越川滋行
    TKB_EvoDevo 2013年08月 公開講演，セミナー，チュートリアル，講習，講義等

作品等

その他活動・業績

  • ショウジョウバエの水玉模様をGal4/UASで改変する試み
    古関将斗, 越川滋行 日本進化学会第25回沖縄大会（ポスター発表）P-092Y 2023年09月02日 [査読無し][通常論文]
  • Co-option of the ancestral cis-regulatory sequences underlying the gain of new wing pigmentation pattern in Drosophila guttifera
    Takumi Karasawa, Namiho Saito, Shigeyuki Koshikawa 日本進化学会第25回沖縄大会（英語口頭発表）O1D-07Y 2023年09月01日 [査読無し][通常論文]
  • ショウジョウバエの水玉模様の獲得におけるcis制御の進化
    柄澤匠, 越川滋行 第1回北海道バイオ"Mix up" （北海道大学農学部、札幌）口頭発表 2023年08月09日 [査読無し][通常論文]
  • ミズタマショウジョウバエの翅の種特異的な模様の獲得における制御配列の進化と既存配列の転用
    柄澤匠, 齊藤奈美歩, 越川滋行 日本動物学会 北海道支部 第67回大会（旭川市公民館木楽輪）口頭発表 2023年03月18日 [査読無し][通常論文]
     
    最優秀発表賞
  • ミズタマショウジョウバエにおけるGal4/UASシステムの開発
    古関将斗, 越川滋行 日本動物学会 北海道支部 第67回大会（旭川市公民館木楽輪）口頭発表 2023年03月18日 [査読無し][通常論文]
  • 洞窟種を含むチビゴミムシ亜科3種の視覚関連遺伝子の比較
    丹伊田 拓磨, 越川 滋行 第67回日本応用動物昆虫学会大会（摂南大学、大阪）ポスター発表PS0314-03 2023年03月14日 [査読無し][通常論文]
  • Development of Gal4/UAS system for elucidating the mechanism of the wing color pattern formation of Drosophila guttifera
    Masato Koseki, Shigeyuki Koshikawa 64th Annual Drosophila Research Conference 2023年03月01日 [査読無し][通常論文]
  • Pre-existing Mad binding site is required for novel expression pattern of wingless in Drosophila guttifera pupal wing
    Takumi Karasawa, Namiho Saito, Shigeyuki Koshikawa 64th Annual Drosophila Research Conference 2023年03月01日 [査読無し][通常論文]
  • ミズタマショウジョウバエの翅の新しい模様形成に必要なcis制御配列の特定
    柄澤匠, 齊藤奈美歩, 越川滋行 日本動物学会第93回早稲田大会（口頭発表）3E37-1045 2022年09月10日 [査読無し][通常論文]
  • 地下浅層に生息するチビゴミムシのオプ シン遺伝子と走光性
    丹伊田拓磨, 越川滋行 日本昆虫学会第82回大会（松本）ポスター発表PB02 2022年09月04日 [査読無し][通常論文]
     
    最優秀ポスター賞
  • cis制御領域におけるSmadの結合配列の獲得が新しい遺伝子発現のパターンを生み出した
    柄澤 匠, 齊藤奈美歩, 越川滋行 日本進化学会年大会 第24回沼津大会 ポスター発表 P-51 2022年08月05日 [査読無し][通常論文]
  • 野生種ショウジョウバエにおけるゲノム編集と模様研究への適用
    越川滋行 日本動物学会北海道支部主催2021年度公開シンポジウム「野生動物のゲノム研究最前線」 2021年12月17日 [査読無し][招待有り]
  • ミズタマショウジョウバエを用いた Wingless モルフォゲンによる模様形成機構の解析
    福冨雄一, 重信秀治, 越川滋行 日本遺伝学会第93回大会 2D-05 オンライン口頭発表 2021年09月09日
  • ミズタマショウジョウバエの翅の模様、形成メカニズムと機能
    越川滋行, 古関将斗, 丹伊田拓磨, 福冨雄一 日本遺伝学会第93回大会 WS4: 形と行動の多様性の遺伝学 ショウジョウバエ近縁種を用いた研究から オンライン口頭発表 2021年09月08日 [査読無し][招待有り]
  • 神経組織の構成細胞における遺伝子発現の進化がもたらしたショウジョウバエの水玉模様
    古関 将斗, 田中 暢明, 越川 滋行 日本動物学会第92回オンライン米子大会 ポスター発表E-10 2021年09月02日 [査読無し][通常論文]
  • Winglessモルフォゲンはどのようにミズタマショウジョウバエの模様を形成するのか？
    福冨雄一, 重信秀治, 越川滋行 日本進化学会第23回東京大会 シンポジウム 9: 昆虫とクマムシのユニークネスを科学しよう! オンライン口頭発表 2021年08月19日 [査読無し][通常論文]
  • 模様形成遺伝子winglessを発現する神経組織の構成細胞の特定
    古関将斗, 越川滋行 日本進化学会第23回オンライン大会 ポスター発表 2021年08月19日 [査読無し][通常論文]
     
    学生発表賞【学部・修士課程】最優秀賞
  • Two types of cells composing a campaniform sensillum express the patterning gene wingless in pupal wings of Drosophila guttifera.
    Masato Koseki, Nobuaki Tanaka, Shigeyuki Koshikawa 62nd Annual Drosophila Research Conference, online poster 2021年03月30日 [査読無し][通常論文]
  • ミズタマショウジョウバエの遺伝子変異系統を用いた模様の機能に関する研究
    丹伊田 拓磨, 越川 滋行 第65回日本応用動物昆虫学会大会（島根大学、オンライン）ポスター（PS31） 2021年03月24日 [査読無し][通常論文]
  • Which cell type of campaniform sensilla expresses the patterning gene wingless in pupal wings of Drosophila guttifera?
    古関将斗, 越川滋行 日本進化学会第22回オンライン大会 ポスター (PA-95) 2020年09月08日 [査読無し][通常論文]
  • ミズタマショウジョウバエ胸部における模様形成メカニズムの探索
    矢野根智広, 越川滋行 日本動物学会第91回大会オンライン ポスター (D-14) 2020年09月05日 [査読無し][通常論文]
  • ミズタマショウジョウバエの模様形成遺伝子winglessは、蛹期の翅において鐘状感覚子のどの細胞で発現しているのか？
    古関将斗, 越川滋行 日本動物学会第91回大会オンライン ポスター (E-01) 2020年09月04日 [査読無し][通常論文]
  • ミズタマショウジョウバエを用いた模様形成遺伝子ネットワークの探索
    福冨雄一, 重信秀治, 越川滋行 日本動物学会第91回大会オンライン ポスター (B-15) 2020年09月04日 [査読無し][通常論文]
  • ミズタマショウジョウバエの水玉模様が配偶者選択により進化した可能性
    丹伊田拓磨, 越川滋行 第64回日本応用動物昆虫学会大会（新型コロナウイルス感染症の感染拡大によりみなし開催） ポスター (PS025) 2020年03月16日 [査読無し][通常論文]
  • Transcriptome analysis of Drosophila guttifera to elucidate the gene network related to color pattern formation
    Yuichi Fukutomi, Shuji Shigenobu, Shigeyuki Koshikawa 5th Asia-Pacific Drosophila Research Conference 2020年01月09日 [査読無し][通常論文]
  • Thoughts on function of Drosophila guttifera wing color pattern
    Takuma Niida, Shigeyuki Koshikawa 5th Asia-Pacific Drosophila Research Conference 2020年01月 [査読無し][通常論文]
  • Pigmentation pattern formation in Drosophila guttifera
    Shigeyuki Koshikawa, Keiji Matsumoto, Wataru Yamamoto, Yuichi Fukutomi 5th Asia-Pacific Drosophila Research Conference 2020年01月 [査読無し][通常論文]
  • ミズタマショウジョウバエの模様が作られる仕組み
    越川滋行, 福冨雄一, 松本圭司 日本動物学会第90回大会 S-23 遺伝的変異-発生・生理-適応度をつなぐ進化・多様性研究 2019年09月 [査読無し][招待有り]
  • 模様形成遺伝子の探索 〜ミズタマショウジョウバエのトランスクリプトーム解析〜
    福冨雄一, 重信秀治, 越川滋行 日本進化学会 第21回 北海道大会 シンポジウム S10 模様研究のあした ~ 形成機構や機能 ~ 2019年08月 [査読無し][通常論文]
  • ミズタマショウジョウバエの模様で発現する遺伝子の解明のためのトランスクリプトーム解析
    福冨雄一, 重信秀治, 越川滋行 日本発生生物学会 第52回大会 大阪 2019年05月 [査読無し][通常論文]
  • Enhancer function and evolution of polka-dots in Drosophila guttifera
    Shigeyuki Koshikawa, Yuichi Fukutomi 日本発生生物学会第52回大会 Symposium 4:Enhancer function explaining morphological diversity 2019年05月 [査読無し][招待有り]
  • Generation mechanism of a polka-dot pattern in Drosophila guttifera.
    越川滋行, 松本圭司, 福冨雄一 第46回内藤コンファレンス ショートトーク 2018年10月 [査読有り][通常論文]
  • ミズタマショウジョウバエの模様はどのように作られるのか？
    越川滋行, 福冨雄一, 松本圭司 日本動物学会第89回大会 S3 遺伝的変異―発生・生理―適応度を繋ぐ生物多様性研究 2018年09月 [査読無し][招待有り]
  • カイコyellow遺伝子の発現制御領域のエンハンサー解析とシスモジュール制御
    鈴木誉保, 越川滋行, 小林功, 内野恵郎, 瀬筒秀樹 蚕糸・昆虫機能利用学術講演会（日本蚕糸学会第88回大会） 2018年03月 [査読無し][通常論文]
  • ミズタマショウジョウバエの翅の着色過程の解明と模様形成遺伝子同定法
    福冨雄一, 松本圭司, 船山典 子, 越川滋行 日本進化学会第19回大会 2017年08月 [査読無し][通常論文]
  • ミズタマショウジョウバエの模様形成の仕組み
    越川滋行 蚕糸・昆虫機能利用学術講演会（日本蚕糸学会第87回大会） 2017年03月21日 [査読無し][招待有り]
  • Origins of evolutionary novelty: Developmental regulation and evolution of color pattern formation in a polka-dotted fruit fly, Drosophila guttifera.
    越川滋行 NIGシンポジウム2016 2016年12月26日 [査読無し][招待有り]
  • Wing color pattern formation in a polka-dotted fruit fly Drosophila guttifera
    越川滋行, 福冨雄一, 松本圭司 国際動物学会、日本動物学会合同大会 2016年11月17日 [査読無し][通常論文]
  • Unique mechanism of pigmentation pattern formation in the polka-dotted fly, Drosophila guttifera
    福冨雄一, 船山典子, 越川滋行 国際動物学会、日本動物学会合同大会 2016年11月17日 [査読無し][通常論文]
  • ミズタマショウジョウバエの模様形成機構の理解に向けて
    越川滋行, 福冨雄一, 松本圭司 日本遺伝学会第88回大会 WS1 ショウジョウバエの進化・集団遺伝学 2016年09月 [査読無し][招待有り]
  • Drosophila guttifera as a model system for elucidating color pattern formation
    越川滋行, 福冨雄一, 松本圭司 チョウの斑紋多様性理解に向けた統合的アプローチ 2016年08月02日 [査読無し][通常論文]
  • Wing development and pigmentation process in pupae of polka-dotted fly Drosophila guttifera
    福冨雄一, 船山典子, 阿形清和, 越川滋行 JSDB Special Symposium: Frontier of Developmental Biology (+ 49th Meeting) 2016年06月02日 [査読無し][通常論文]
  • 福冨雄一, 阿形清和, 越川滋行 日本応用動物昆虫学会大会講演要旨 60th 171 2016年03月10日 [査読無し][通常論文]
  • 越川滋行 日本生化学会大会(Web) 分子生物学会共催 88th 3W8-2 (WEB ONLY) 2015年12月 [査読無し][招待有り]
  • 鈴木誉保, 越川滋行 日本進化学会ニュース 16 (3) 12 -13 2015年11月 [査読無し][招待有り]
  • 模様の進化を引き起こした遺伝的変化
    越川滋行 日本進化学会第17回大会 S-02 2015年08月 [査読無し][招待有り]
  • Toward understanding color pattern formation and evolution in Drosophila
    越川滋行, Matt W. Giorgianni, Kathy Vaccaro, Victoria A. Kassner, John H. Yoder, Thomas Werner, Sean B. Carroll 日本発生生物学会第48回大会 OP01-3 2015年06月 [査読無し][通常論文]
  • 越川滋行 日本応用動物昆虫学会大会講演要旨 59th 114 2015年03月 [査読無し][通常論文]
  • Presoldier cuticle contributes to the soldier morphogenesis in termites
    杉目康広, 小川浩太, 渡邊大, 越川滋行, 下地博之, 三浦徹 国際社会性昆虫学会第17回大会 OR110 2014年07月 [査読無し][通常論文]
  • Evolution of cis-regulatory elements for the wingless gene in Drosophila guttifera
    越川滋行, Matt W. Giorgianni, Kathy Vaccaro, Victoria A. Kassner, John H. Yoder, Thomas Werner, Sean B. Carroll 第11回日本ショウジョウバエ研究会 S9 2014年06月 [査読無し][通常論文]
  • 杉目康広, 越川滋行, 三浦徹 日本応用動物昆虫学会大会講演要旨 58th 151 2014年03月 [査読無し][通常論文]
  • cis制御因子の進化による新しいwingless遺伝子発現ドメインの獲得
    越川滋行, Matt W. Giorgianni, Thomas Werner, Kathy Vaccaro, Victoria Kassner, John H Yoder, Sean B Carroll 日本進化学会第15回大会 2013年08月 [査読無し][通常論文]
  • Evolution of a novel wing pigmentation pattern in Drosophila : when engrailed crosses the line
    Héloïse D. Dufour, Cédric Finet, 越川滋行, Jane E. Selegue, Sean B. Carroll 54th Annual Drosophila Research Conference 2013年04月 [査読無し][通常論文]
  • 越川滋行 日本動物学会大会予稿集 82nd 78 2011年08月 [査読無し][招待有り]
  • Sociogenomics in Termites: Caste Development and Underlying Developmental and Physiological Systems
    Miura T, Cornette R, Ishikawa Y, Hattori A, Gotoh H, Hayashi Y, Koshikawa S 20th CDB Meeting Kobe 2011年02月 [査読無し][通常論文]
  • 新奇で複雑な形質の進化―ショウジョウバエの斑紋形成 メカニズムを例に―
    越川滋行, Thomas Werner, Thomas M Williams, Sean B Carroll 日本進化学会第11回大会 W2D 2009年09月 [査読無し][招待有り]
  • 幼若ホルモンがクワガタのアロメトリーを決定する
    後藤 寛貴, コルネット リシャー, 越川 滋行, 岡田 泰和, 三浦 徹 日本進化学会第11回大会 2009年08月 [査読無し][通常論文]
  • Juvenile hormone determines the scaling relationship in stag beetle
    後藤寛貴, Cornette R, 越川滋行, 岡田泰和, 三浦徹 Evolution 2009 2009年06月 [査読無し][通常論文]
  • クワガタの大顎サイズに環境が与える影響とその発生学的背景について
    後藤 寛貴, コルネット リシャー, 越川 滋行, 岡田 泰和, 三浦 徹 日本昆虫学会第68回大会 2008年09月 [査読無し][通常論文]
  • 堀川大樹, 越川滋行, 阿部渉, 中原雄, 渡邊匡彦, 東正剛, 三浦徹, 國枝武和, 奥田隆 日本応用動物昆虫学会大会講演要旨 52nd 152 2008年03月 [査読無し][通常論文]
  • クワガタにおける誇張された形態の発生学的研究
    後藤寛貴, 越川滋行, コルネット リシャー, 岡田泰和, 三浦 徹 日本応用動物昆虫学会・日本昆虫学会共催 北海道支部大会 2008年02月 [査読無し][通常論文]
  • 三浦徹, 石川由希, CORNETTE Richard, 越川滋行 日本動物学会大会要旨集 78th 122 2007年08月 [査読無し][通常論文]
  • 越川滋行, 服部章子, 三浦徹 日本動物学会大会要旨集 78th 33 2007年08月 [査読無し][通常論文]
  • 三浦徹, 越川滋行, CORNETTE Richard, 藤田愛, 石川由希, 北條優, 前川清人, 松本忠夫 日本生態学会大会講演要旨集 53rd 207 2006年03月 [査読無し][通常論文]
  • 前川清人, 水野さやか, 越川滋行, 三浦徹 日本生態学会大会講演要旨集 53rd 207 2006年03月 [査読無し][通常論文]

受賞

  • 2020年09月 北海道大学高等教育推進機構 エクセレント・ティーチャー（令和元年度）
     生物学II 
    受賞者: 越川滋行
  • 2016年11月 日本動物学会 成茂動物科学振興賞
     ミズタマショウジョウバエの模様形成機構と進化 
    受賞者: 越川滋行
  • 2016年08月 日本進化学会 研究奨励賞
     昆虫の新奇形質に関する発現機構の解明 
    受賞者: 越川滋行
  • 2014年04月 京都大学 白眉センター 白眉研究者（第5期）
     
    受賞者: 越川滋行

共同研究・競争的資金等の研究課題

教育活動情報

主要な担当授業

  • 生態遺伝学特論Ⅰ
    開講年度 : 2021年
    課程区分 : 修士課程
    開講学部 : 環境科学院
    キーワード : 集団、遺伝的変異、遺伝的多様性、保全、生態と発生 population, genetic variation, genetic diversity, conservation, ecology and development
  • 生物圏科学実習Ⅰ
    開講年度 : 2021年
    課程区分 : 修士課程
    開講学部 : 環境科学院
    キーワード : DNA、クローニング、遺伝子ライブラリー、シークエンス、PCR、分子系統解析 DNA, cloning, genomic library, sequencing, PCR, molecular phylogenetic analyses
  • 生物圏科学実習Ⅱ
    開講年度 : 2021年
    課程区分 : 修士課程
    開講学部 : 環境科学院
    キーワード : 遺伝的多様性、フェノロジー、共生、多型、表現型可塑性 Genetic diversity, phenology, symbiosis, polymorphism, phenotypic plasticity
  • 生態学基礎論
    開講年度 : 2021年
    課程区分 : 修士課程
    開講学部 : 環境科学院
    キーワード : 生物進化、種分化、生物多様性、環境適応、絶滅 evolution, speciation, bio-diversity, adaptation, extinction
  • 多様性生物学概論
    開講年度 : 2021年
    課程区分 : 修士課程
    開講学部 : 理学院
    キーワード : 生物進化、種分化、生物多様性、環境適応、絶滅
  • 科学・技術の世界（1単位）
    開講年度 : 2021年
    課程区分 : 学士課程
    開講学部 : 全学教育
    キーワード : 現代生物科学，21世紀に生物科学が解決しなければならない課題，生物の多様性，系統，進化，生物の形態，生命活動の多様性
  • 生物学Ⅱ
    開講年度 : 2021年
    課程区分 : 学士課程
    開講学部 : 全学教育
    キーワード : 生物の多様性，系統，進化，生物の形態，生命活動の多様性
  • 自然科学実験
    開講年度 : 2021年
    課程区分 : 学士課程
    開講学部 : 全学教育
    キーワード : 自然科学実験、物理学、化学、生物学、地球惑星科学
  • 多様性生物学Ⅲ
    開講年度 : 2021年
    課程区分 : 学士課程
    開講学部 : 理学部
    キーワード : 生態、種間相互作用、個体群、生物群集
  • 生物学特別講義Ⅴ
    開講年度 : 2021年
    課程区分 : 学士課程
    開講学部 : 理学部
    キーワード : 形態進化、性選択、性的二型、進化発生
  • 環境生物学Ⅱ
    開講年度 : 2021年
    課程区分 : 学士課程
    開講学部 : 理学部
    キーワード : 生物多様性、環境変遷、適応、遺伝的変異、遺伝機構、比較ゲノム、共生、絶滅、孤立化、保全、遺伝的モニタリング

大学運営

委員歴

  • 2022年10月 - 現在   北海道大学環境科学同窓会   幹事長
  • 2017年10月 - 現在   北海道大学環境科学同窓会   幹事

その他

  • 2022年07月 - 9999年  日本進化学会 代議員
  • 2022年04月 - 9999年  日本動物学会 広報委員
  • 2021年09月 - 9999年  日本ショウジョウバエ研究会 世話役
  • 2020年12月 - 9999年  日本進化学会 編集委員
  • 2020年09月 - 9999年  日本動物学会 北海道支部 札樽地区委員
  • 2017年04月 - 2023年03月  文部科学省 科学技術・学術政策研究所 科学技術予測センター 専門調査員
  • 2022年  日本遺伝学会第94回大会（札幌） 
    実行委員
  • 2019年07月 - 2021年06月  日本動物学会 北海道支部 会計幹事
  • 2019年08月 - 2019年08月  日本進化学会第21回大会（札幌） 
    実行委員
  • 2018年08月 - 2018年08月  日本動物学会第89回大会（札幌） 
    実行委員会
  • 2017年08月 - 2017年08月  日本進化学会第19回大会（京都） 
    大会実行委員
  • 2013年12月 - 2016年10月  Evo-Devo青年の会 幹事

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