研究者データベース

岩崎 由加子(イワサキ ユカコ)
医学研究院 医理工学グローバルセンター
学術研究員

基本情報

所属

  • 医学研究院 医理工学グローバルセンター

職名

  • 学術研究員

学位

  • 修士(工学)

J-Global ID

研究分野

  • ナノテク・材料 / 生物分子化学
  • ライフサイエンス / ゲノム生物学
  • ライフサイエンス / 免疫学
  • ライフサイエンス / 内科学一般

研究活動情報

論文

  • Yasuyuki Nagasawa, Daisuke Okuzaki, Eri Muso, Ryohei Yamamoto, Maki Shinzawa, Yukako Iwasaki, Hirotsugu Iwatani, Takeshi Nakanishi, Yoshitaka Isaka, Hiroshi Nojima
    PLOS ONE 11 4 e0153252  2016年04月 [査読有り][通常論文]
     
    Diagnosis of chronic glomerulonephritis (CGN) depends primarily on renal biopsy, which is expensive and requires hospitalization, creating a demand for noninvasive diagnostic method for this disease. We used DNA microarray analysis to search for genes whose expression levels in peripheral blood mononuclear cells (PBMCs) could distinguish between patients with CGN and healthy volunteers (HVs). We selected immunoglobulin A nephropathy (IgAN) and membranous nephropathy (MN) as typical forms of CGN. The mRNA level of the gene encoding interferon (IFN)-alpha-inducible protein 27, IFI27, which is preferentially expressed in podocytes of glomeruli, was lower in PBMCs of IgAN and MN patients than in those of HVs. This result was confirmed by quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR). Moreover, qRT-PCR analysis revealed that the IFI27 mRNA level was reduced in PBMCs of patients with other types of chronic glomerulonephritis. IFI27 immunohistochemical staining of biopsied specimens also confirmed reduced expression of IFI27 protein in IgAN and MN patients. Based on these results, we propose that IFI27 could serve as a noninvasive diagnostic marker for CGNs using peripheral blood.
  • Kyoko Tobino, Eri Muso, Yukako Iwasaki, Satomi Yonemoto, Kenji Kasuno, Tatsuo Tsukamoto, Hajime Nakamura, Yasuhiko Tomino
    NEPHROLOGY 20 5 368 - 374 2015年05月 [査読有り][通常論文]
     
    Aim: The role of urinary (U-) thioredoxin (Trx), a class of small redox proteins, in physiological and pathological conditions, in addition to its gender specificity, has been insufficiently determined in chronic kidney disease (CKD) patients, especially in diabetes mellitus (DM) nephropathy. Methods: U-Trx was measured cross-sectionally in 110 CKD outpatients with estimated glomerular filtration rate (eGFR) of >15 mL/min per 1.73 m(2), namely, in 57 type 2 DM patients (male: n = 41, female: n = 16) and 53 non-DM patients (M: n = 33, F: n = 20), as well as 30 healthy controls (M: n = 11, F: n = 19). Comparisons were made among controls, DM and non-DM, and between M and F, with clinical parameters compared in each group. In addition, a comparison between average U-Trx level and the changes of renal function during a one-year period was performed. Results: U-Trx was significantly higher in females than in males in controls (P < 0.05) and in non-DM patients (P < 0.05). Multiple regression analysis revealed that urinary protein (UP)/creatinine (Cr) ratio, female sex and HbA1c were independent factors affecting U-Trx among all subjects (adjusted R-2 = 0.468). In DM patients, U-Trx was negatively correlated with eGFR, especially in males, and positively correlated with UP/Cr and NAG in both sexes (all P < 0.01), as well as with systolic blood pressure in all (P < 0.05). Average U-Trx was positively correlated with the rate of annual eGFR decline of male (P < 0.01) but not female DM patients. Conclusion: U-Trx might have a gender-specific physiological and pathological role and be a potent marker of renal damage in DM nephropathy.
  • Muso Eri, Gu Jingwen, Nakamura Hajime, Yoshii Teruko, Nagaoka Masami, Tanaka Megumi, Fukuya Yukari, Iwasaki Yukako, Zou Hegian
    NEPHROLOGY 19 58 - 58 2014年05月 [査読有り][通常論文]
  • Eri Muso, Daisuke Okuzaki, Shigeto Kobayashi, Yukako Iwasaki, Minami A. Sakurai, Akihiko Ito, Hiroshi Nojima
    AUTOIMMUNITY 46 8 513 - 524 2013年12月 [査読有り][通常論文]
     
    Microscopic polyangiitis (MPA) is a systemic autoimmune disease that often has a fatal outcome. Although delineating the molecular pathogenesis is essential for its remedy, an understanding of its molecular mechanism has remained elusive. To search for new markers of active lesions that might help better understand the molecular basis of MPA and aid in its diagnosis, we here performed DNA microarray analysis with peripheral blood mononuclear cells (PBMCs). Compared to normal control, several genes were up-or down-regulated in MPA patients, including up-regulation of the mRNA level of ficolin-1 (FCN1 or M-ficolin), an innate pattern recognition complement molecule. The amount of ficolin-1, as detected by immunohistochemistry, was higher in the glomeruli of another group of MPA patients than in the glomeruli of control patients who harbored almost normal glomeruli. Many of the ficolin-1 dots were also positive for CD68, suggesting that the ficolin-1-positive cells were monocytes, such as macrophages or dendritic cells. This is not due to the difference in the number of neutrophil or monocytes in the blood samples of MPA and control patients. Taken together, we conclude that increased ficolin-1 expression could serve as a new marker for the characterization of MPA, especially when it is associated with local active lesions.
  • Eri Muso, Tomomi Endo, Mitsuyo Itabashi, Hiroko Kakita, Yukako Iwasaki, Yu Tateishi, Toshiyuki Komiya, Toshiko Ihara, Wako Yumura, Takao Sugiyama, Kensuke Joh, Kazuo Suzuki
    Clinical and Experimental Nephrology 17 5 659 - 662 2013年10月 [査読有り][通常論文]
     
    The prognostic value of renal biopsy in anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis is widely recognized however, there is no consensus regarding its pathological classification. Berden et al. proposed a new classification of glomerulonephritis in ANCA-associated vasculitis (AAV) categorized into focal, crescentic, mixed, and sclerotic classes and showed its prognostic value in 100 international multicenter cohorts for 1- and 5-year renal outcomes. In order to evaluate whether this new classification has predictive value and reproducibility in Japanese AAV cases, 87 cohorts with only microscopic polyangiitis in 3 limited centers in Japan were analyzed. In addition, those from Japan, Europe (Berden's cohorts) and China were compared in a recent report. © 2012 The Author(s).
  • Eri Muso, Kensuke Joh, Toshiko Ihara, Yukako Iwasaki, Toshiyuki Komiya, Kazuo Suzuki
    APMIS 117 151 - 151 2009年06月 [査読有り][通常論文]
  • Mari Tanaka, Sachiko Yamada, Yukako Iwasaki, Takeshi Sugishita, Satomi Yonemoto, Tatsuo Tsukamoto, Satoshi Fukui, Kosho Takasu, Eri Muso
    NEPHRON CLINICAL PRACTICE 112 2 C71 - C78 2009年 [査読有り][通常論文]
     
    Background: The pathological role of obesity in the progression of glomerular lesions has rarely been studied in primary glomerular diseases. The purpose of this study is to investigate the influence of non-diabetic obesity on clinicopathological findings in IgA nephropathy. Methods: 74 patients with biopsy-proven IgA nephropathy were retrospectively divided into two groups according to the criteria for obesity in Japan: non-obese group (group N: n = 50) with BMI < 25 kg/m(2), and obese group (group O: n = 24) with BMI >= 25 kg/m(2). Clinical and pathological data at the time of renal biopsy were analyzed. Moreover, the outcome of proteinuria in patients treated with angiotensin-converting enzyme inhibitors (ACE-I) or angiotensin II receptor blockers (ARB) was evaluated in different groups after a 1-year follow-up. Results: Urinary protein excretion was significantly greater in the obese group compared to normal-weight patients (p < 0.05). There was no significant difference in the prevalence of hypertension and hyperlipidemia. By light microscopy, the obese group showed significantly larger glomerular size (p < 0.0001). On the other hand, the severity of mesangial matrix expansion and crescent formation revealed no difference between the two groups. By electron microscopy, glomerular basement membrane (GBM) thickness was significantly increased in obese patients (p < 0.001). Among 61 patients who were followed up for 1 year in our institute, 15 patients were treated with ACE-I or ARB without steroids. ACE-I or ARB treatment without steroids tended to reduce proteinuria in the obese patients, but this change did not achieve statistical significance. Conclusions: In IgA nephropathy, obesity induces not only glomerular enlargement but also ultrastructural modification of GBM, which would contribute to increase proteinuria. Copyright (C) 2009 S. Karger AG, Basel
  • Tanaka M, Yamada S, Iwasaki Y, Sugishita T, Yonemoto S, Tsukamoto T, Fukui S, Takasu K, Muso E
    Nephron. Clinical practice 112 2 c71 - 8 2009年 [査読有り][通常論文]
  • Mari Tanaka, Tomomi Tsujii, Toshiyuki Komiya, Yukako Iwasaki, Takeshi Sugishita, Satomi Yonemoto, Tatsuo Tsukamoto, Satoshi Fukui, Akimasa Takasu, Eri Muso
    IGA NEPHROPATHY TODAY 157 90 - 93 2007年 [査読有り][通常論文]
     
    The pathological role of obesity has rarely been studied in primary glomerular diseases. The purpose of this study is to examine the clinicopathological influence of obesity in IgA nephropathy (IgAN). 74 patients with IgA nephropathy in our institution from October 2000 to January 2004 were retrospectively divided into two groups according to body mass index (BMI): the non-obese group (group N) with BMI < 25 kg/m(2), and the obese group (group O) with BMI >= 25 kg/m(2). There were 50 patients in group N and 24 patients in group O. Clinical analysis showed no significant difference between these two groups in blood pressure, serum cholesterol, creatinine clearances or grade of hematuria. However, urinary protein excretion and serum creatinine were significantly greater in group o than in group N. Although semi quantitative analysis of light-microscopical findings showed no significant differences in the severity of mesangial proliferation, matrix expansion, glomerulosclerosis or crescent formation, image analysis showed that total glomerular area and tuft area were significantly larger in group O. In addition, ultrastructural study revealed significantly higher glomerular basement membrane thickness in group O. 62 patients (46 patients, group N,16 patients, group O) were followed in our institution for one year. Urinary protein was significantly decreased only in patients who received steroid in both groups. Although administration of ACE inhibitor or ARB tended to decrease urinary protein in group o, the change was not statistically significant. Our findings indicate that obesity may accelerate the increase of proteinuria in IgAN through ultrastructural modification of the glomerular basement membrane. Copyright (c) 2007 S. Karger AG, Basel.

講演・口頭発表等

  • がん放射線治療における仕事との両立に関する全国施設アンケート調査結果
    岩崎由加子, 白土博樹, 立石清一郎, 青山英史, 高橋健夫, 茂松直之, 北海道大学医学研究院医理工学グローバルセンター, 北海道大, 医, 両立医, 産業医科大学両立支援科学講座, 北海道大, 医, 放射線治療, 埼玉医科大, 放射線腫瘍科, 医, 放射線治療科
    2020年10月

その他活動・業績

  • がん放射線治療における仕事との両立に関する全国施設アンケート調査結果
    岩崎由加子, 白土博樹, 立石清一郎, 青山英史, 高橋健夫, 茂松直之, 北海道大学医学研究院医理工学グローバルセンター, 北海道大, 医, 両立医, 産業医科大学両立支援科学講座, 北海道大, 医, 放射線治療, 埼玉医科大, 放射線腫瘍科, 医, 放射線治療科 日本放射線腫瘍学会学術大会報文集 33 288 -288 2020年10月
  • 垣田浩子, 岩崎由加子, 矢野景子, 石村拓也, 半田貴也, 有安由紀, 高田大輔, 新川神奈, 遠藤知美, 鈴木洋行, 米本智美, 渡邊武, 武曾惠理 日本腎臓学会誌 58 (3) 372 -372 2016年05月10日 [査読無し][通常論文]
  • 垣田浩子, 岩崎由加子, 半田貴也, 有安由紀, 新川神奈, 山口亮平, 姜伶名, 遠藤知美, 鈴木洋行, 米本智美, 武曾惠理 日本腎臓学会誌 57 (3) 547 -547 2015年04月30日 [査読無し][通常論文]
  • 飛野杏子, 武曾恵理, 岩崎由加子, 米本智美, 塚本達雄, 中村肇 日本腎臓学会誌 56 (3) 352 -352 2014年05月25日 [査読無し][通常論文]
  • 遠藤知美, 板橋美津世, 杉山隆夫, 岩崎由加子, 垣田浩子, 湯村和子, 城謙輔, 鈴木和男, 武曾惠理 日本腎臓学会誌 55 (3) 303 -303 2013年04月25日 [査読無し][通常論文]
  • 飛野杏子, 武曾惠理, 岩崎由加子, 米本智美, 塚本達雄, 中村肇 日本腎臓学会誌 54 (3) 258 -258 2012年04月25日 [査読無し][通常論文]
  • 遠藤知美, 岩崎由加子, 宇野賀津子, 垣田浩子, 古宮俊幸, 三宅崇文, 池田昌樹, 猪原登志子, 米本智美, 塚本達雄, 城謙輔, 鈴木和男, 武曾惠理 日本腎臓学会誌 54 (3) 216 -216 2012年04月25日 [査読無し][通常論文]
  • 飛野杏子, 岩崎由加子, 草部牧子, 佐藤有紀, 近藤尚哉, 立石悠, 米倉由利子, 古宮俊幸, 米本智美, 塚本達雄, 武曾惠理, 中村肇 日本腎臓学会誌 52 (3) 371 -371 2010年05月25日 [査読無し][通常論文]
  • 塚本達雄, 杉下岳詩, 岩崎由加子, 佐藤有紀, 近藤尚哉, 立石悠, 米倉由利子, 飛野杏子, 古宮俊幸, 米本智美, 福内史子, 武曾惠理 日本透析医学会雑誌 42 (Supplement 1) 543 -543 2009年05月08日 [査読無し][通常論文]
  • 古宮俊幸, 岩崎由加子, 佐藤有紀, 近藤尚哉, 立石悠, 米倉由利子, 飛野杏子, 米本智美, 福内史子, 塚本達雄, 藤川潤, 武曾惠理 日本腎臓学会誌 51 (3) 262 -262 2009年04月25日 [査読無し][通常論文]
  • 塚本達雄, 杉下岳詩, 岩崎由加子, 近藤尚哉, 森田龍頼, 立石悠, 糟野健司, 米本智美, 福内史子, 武曾恵理 日本透析医学会雑誌 41 (Supplement 1) 423 -423 2008年05月20日 [査読無し][通常論文]
  • 古宮俊幸, 辻井知美, 米本智美, 岩崎由加子, 杉下岳詩, 立石悠, 糟野健司, 福内史子, 塚本達雄, 藤川潤, 武曾恵理 日本腎臓学会誌 50 (3) 288 -288 2008年04月25日 [査読無し][通常論文]
  • 武曾恵理, 宇野賀津子, 城謙輔, 岩崎由加子, 塚本達雄, 古宮俊幸, 糟野健司, 鈴木和男 日本腎臓学会誌 50 (3) 297 -297 2008年04月25日 [査読無し][通常論文]
  • 辻井知美, 野津寛大, 岩崎由加子, 古宮俊幸, 福内史子, 塚本達雄, 武曾惠理 日本腎臓学会誌 49 (3) 239 -239 2007年04月25日 [査読無し][通常論文]
  • 辻井知美, 古宮俊幸, 米本智美, 岩崎由加子, 杉下岳詩, 福内史子, 塚本達雄, 藤川潤, 武曾惠理 日本腎臓学会誌 49 (3) 260 -260 2007年04月25日 [査読無し][通常論文]
  • 塚本達雄, 杉下岳詩, 岩崎由加子, 立石悠, 古宮俊幸, 福内史子, 武曾恵理 日本腎臓学会誌 49 (3) 351 -351 2007年04月25日 [査読無し][通常論文]
  • 塚本達雄, 杉下岳詩, 岩崎由加子, 立石悠, 古宮俊幸, 福内史子, 武曾惠理 ICUとCCU 31 S22-S24 2007年03月31日 [査読無し][通常論文]
  • 【急性腎不全の基礎と新たな治療法への期待】 虚血性腎尿細管細胞における細胞間接着装置の変化
    塚本 達雄, 杉下 岳詩, 岩崎 由加子, 立石 悠, 古宮 俊幸, 福内 史子, 武曾 惠理 ICUとCCU 31 (別冊) S22 -S24 2007年03月 [査読無し][通常論文]
     
    尿細管のタイト・ジャンクションやアドヘレンス・ジャンクションはアクチン細胞骨格と密接に関連しているため、虚血時にはこれら細胞間接着装置(JC)を構成する分子複合体も機能的・構造的に破壊されることで"バリアー機能"が破綻し、尿細管腔から間質への非選択的再吸収をきたすことにより急性腎不全に至るという機序が近年明らかにされた。"バリアー機能"をできるだけ維持し、早期に再構成させることは急性虚血性腎不全治療に新たな局面をもたらす可能性があり、JCの分子レベルにおける変化の解明はこの点で重要な意味をもつと考えられる。そこで今回、尿細管培養細胞とマウス虚血腎モデルを用いてJC構成膜蛋白の変化について検討した。結果、虚血尿細管細胞において、JCを構成する膜蛋白は「限定分解」「細胞内への取り込み」「細胞膜上での拡散」などの変化を受け、さらに細胞質内のJC足場蛋白は「脱リン酸化」などの変化を受けアクチン細胞骨格の変性・破壊とともに分子複合体として凝集するが、比較的障害度の軽い尿細管での再灌流時には細胞自らがJC構成分子複合体を機能的・構造的に再構成することが明らかになった。
  • Mari Tanaka, Tomomi Tsujii, Toshiyuki Komiya, Yukako Iwasaki, Takeshi Sugishita, Satomi Yonemoto, Tatsuo Tsukamoto, Satoshi Fukui, Akimasa Takasu, Eri Muso IGA NEPHROPATHY TODAY 157 90 -93 2007年 [査読無し][通常論文]
     
    The pathological role of obesity has rarely been studied in primary glomerular diseases. The purpose of this study is to examine the clinicopathological influence of obesity in IgA nephropathy (IgAN). 74 patients with IgA nephropathy in our institution from October 2000 to January 2004 were retrospectively divided into two groups according to body mass index (BMI): the non-obese group (group N) with BMI < 25 kg/m(2), and the obese group (group O) with BMI >= 25 kg/m(2). There were 50 patients in group N and 24 patients in group O. Clinical analysis showed no significant difference between these two groups in blood pressure, serum cholesterol, creatinine clearances or grade of hematuria. However, urinary protein excretion and serum creatinine were significantly greater in group o than in group N. Although semi quantitative analysis of light-microscopical findings showed no significant differences in the severity of mesangial proliferation, matrix expansion, glomerulosclerosis or crescent formation, image analysis showed that total glomerular area and tuft area were significantly larger in group O. In addition, ultrastructural study revealed significantly higher glomerular basement membrane thickness in group O. 62 patients (46 patients, group N,16 patients, group O) were followed in our institution for one year. Urinary protein was significantly decreased only in patients who received steroid in both groups. Although administration of ACE inhibitor or ARB tended to decrease urinary protein in group o, the change was not statistically significant. Our findings indicate that obesity may accelerate the increase of proteinuria in IgAN through ultrastructural modification of the glomerular basement membrane. Copyright (c) 2007 S. Karger AG, Basel.
  • 塚本達雄, 杉下岳詩, 岩崎由加子, 辻井知美, 古宮俊幸, 武曾恵理 大阪透析研究会会誌 24 (2) 271 2006年09月30日 [査読無し][通常論文]
  • 塚本達雄, 杉下岳詩, 岩崎由加子, 辻井知美, 古宮俊幸, 武曾恵理 日本透析医学会雑誌 39 (Supplement 1) 869 -869 2006年05月18日 [査読無し][通常論文]
  • 古宮俊幸, 岩崎由加子, 浅田秀基, 杉下岳詩, 辻井知美, 田原佐知子, 塚本達雄, 武曾恵理 日本腎臓学会誌 48 (3) 203 -203 2006年04月25日 [査読無し][通常論文]
  • 塚本達雄, 杉下岳詩, 岩崎由加子, 辻井知美, 古宮俊幸, 武曾恵理 日本腎臓学会誌 48 (3) 181 -181 2006年04月25日 [査読無し][通常論文]
  • 辻井知美, 古宮俊幸, 佐々木健一, 米本智美, 岩崎由加子, 杉下岳詩, 塚本達雄, 藤川潤, 武曾恵理 日本腎臓学会誌 48 (3) 210 -210 2006年04月25日 [査読無し][通常論文]
  • 塚本達雄, 杉下岳詩, 岩崎由加子, 辻井知美, 田原佐知子, 古宮俊幸, 武曾恵理 日本腎臓学会誌 47 (3) 355 -355 2005年05月25日 [査読無し][通常論文]
  • 古宮俊幸, 浅田秀基, 岩崎由加子, 杉下岳詩, 辻井知美, 田原佐知子, 塚本達雄, 武曾恵理 日本腎臓学会誌 47 (3) 361 -361 2005年05月25日 [査読無し][通常論文]
  • 塚本達雄, 杉下岳詩, 岩崎由加子, 辻井知美, 田原佐知子, 古宮俊幸, 武曾恵理 日本透析医学会雑誌 38 (Supplement 1) 674 -674 2005年05月18日 [査読無し][通常論文]


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