研究者データベース

大山 紀彦(オオヤマ ノリヒコ)
獣医学研究院 附属動物病院
特任助教

基本情報

所属

  • 獣医学研究院 附属動物病院

職名

  • 特任助教

学位

  • 博士(獣医学)(2019年03月 酪農学園大学)

J-Global ID

研究分野

  • ライフサイエンス / 獣医学

研究活動情報

論文

  • Seiya Maehara, Naoya Matsumoto, Naoaki Takiyama, Yoshiki Itoh, Yasunari Kitamura, Kazuto Yamashita, Tadashi Sano, Takaharu Itami, Norihiko Oyama, Miri Hayashi, Reiko Kato, Arisa Shimode, Arisa Masuko
    The Journal of veterinary medical science 82 6 740 - 744 2020年06月16日 [査読有り][通常論文]
     
    A twenty-year-old male Asiatic black bear (Ursus thibetanus) presented at the Rakuno Gakuen University Animal Medical Center with a 10-year history of bilateral blindness and cataracts. Surgical treatment of bilateral cataracts by extracapsular lensextraction using phacoemulsification and aspiration (PEA) was performed under general anesthesia. An anterior capsulectomy was performed using micro iris scissors and micro anterior lens capsule forceps. The cataract was removed with PEA using the two-handed technique. After surgery, systemic corticosteroids, anti-inflammatory drugs and antibiotics were administered. After cataract removal, the bear had recovered vision, and good quality vision has been maintained to date (15 months). PEA can be a safe and effective treatment for cataracts that impair vision in bears.
  • Seiya Maehara, Naoya Matsumoto, Naoaki Takiyama, Yoshiki Itoh, Yasunari Kitamura, Kazuto Yamashita, Tadashi Sano, Takaharu Itami, Norihiko Oyama, Miri Hayashi, Reiko Kato, Arisa Shimode, Arisa Masuko
    The Journal of veterinary medical science 82 6 740 - 744 2020年06月16日 [査読有り][通常論文]
     
    A twenty-year-old male Asiatic black bear (Ursus thibetanus) presented at the Rakuno Gakuen University Animal Medical Center with a 10-year history of bilateral blindness and cataracts. Surgical treatment of bilateral cataracts by extracapsular lensextraction using phacoemulsification and aspiration (PEA) was performed under general anesthesia. An anterior capsulectomy was performed using micro iris scissors and micro anterior lens capsule forceps. The cataract was removed with PEA using the two-handed technique. After surgery, systemic corticosteroids, anti-inflammatory drugs and antibiotics were administered. After cataract removal, the bear had recovered vision, and good quality vision has been maintained to date (15 months). PEA can be a safe and effective treatment for cataracts that impair vision in bears.
  • Ishikawa Y, Sakata H, Tachibana Y, Itami T, Oyama N, Umar MA, Sano T, Yamashita K
    The Journal of veterinary medical science 81 6 851 - 856 2019年06月 [査読有り][通常論文]
  • Sakata H, Ishikawa Y, Ishihara G, Oyama N, Itami T, Umar MA, Sano T, Yamashita K
    The Journal of veterinary medical science 81 3 425 - 433 2019年01月 [査読有り][通常論文]
  • Itami T, Hanazono K, Oyama N, Sano T, Makita K, Yamashita K
    PloS one 14 7 e0213414  2019年 [査読有り][通常論文]
  • Oyama N, Sano T, Yamamori M, Tamura J, Umar MA, Endo Y, Ishikawa Y, Itoh A, Miyoshi K, Yamashita K
    The Journal of veterinary medical science 2018年08月 [査読有り][通常論文]
  • Sayed Fathi El-Hawari, Hisashi Sakata, Norihiko Oyama, Jun Tamura, Chika Higuchi, Yusuke Endo, Kenjirou Miyoshi, Tadashi Sano, Kazuyuki Suzuki, Kazuto Yamashita
    The Journal of veterinary medical science 80 2 361 - 367 2018年03月02日 [査読有り][通常論文]
     
    The anesthetic and cardiorespiratory effects of xylazine-alfaxalone combination were evaluated in calves. Six calves (age: 6-9 months old; weight: 114-310 kg) were anesthetized with intravenous alfaxalone 15 min after administration of intramuscular saline (0.5 ml/100 kg) or xylazine (0.1 mg/kg; 0.5 ml/100 kg of a 2% xylazine solution). Anesthesia induction was smooth and orotracheal intubation was achieved in all calves. The calves anesthetized with xylazine-alfaxalone required a smaller induction dose of alfaxalone (1.23 ± 0.17 mg/kg, P=0.010) and accepted endotracheal intubation for a significantly longer period (16.8 ± 7.2 min, P=0.022) than the calves anesthetized with alfaxalone alone (2.28 ± 0.65 mg/kg 7.3 ± 1.6 min). At 5 min after induction, tachycardia (heart rate: 166 ± 47 beats/min of heart rate), hypertension (mean arterial blood pressure: 147 ± 81 mmHg) and hypoxemia (partial pressure of arterial blood oxygen [PaO2]: 43 ± 10 mmHg) were observed in the calves anesthetized with alfaxalone alone, whereas hypoxemia (PaO2: 47 ± 7 mmHg) and mild hypercapnia (partial pressure of arterial blood carbon dioxide: 54 ± 5 mmHg) were observed in the calves anesthetized with xylazine-alfaxalone. Premedication with xylazine provided a sparing effect on the induction dose of alfaxalone and a prolongation of anesthetic effect. Oxygen supplementation should be considered to prevent hypoxemia during anesthesia.
  • Sho Fukui, Norihiko Ooyama, Jun Tamura, Mohammed Ahmed Umar, Tomohito Ishizuka, Takaharu Itami, Kenjiro Miyoshi, Tadashi Sano, Kazuto Yamashita
    JOURNAL OF VETERINARY MEDICAL SCIENCE 79 3 502 - 508 2017年03月 [査読有り][通常論文]
     
    Maropitant, a neurokinin-1 receptor antagonist, may provide analgesic effects by blocking pharmacological action of substance P. Carprofen is a non-steroidal anti-inflammatory drug commonly used for pain control in dogs. The purpose of this study was to evaluate the effect of a combination of maropitant and carprofen on the minimum alveolar concentration for blunting adrenergic response (MAC-BAR) of sevoflurane in dogs. Six healthy adult beagle dogs were anesthetized with sevoflurane four times with a minimum of 7-day washout period. On each occasion, maropitant (1 mg/kg) alone, carprofen (4 mg/kg) alone, a combination of maropitant (1 mg/kg) and carprofen (4 mg/kg), or saline (0.1 mI/kg) was subcutaneously administered at 1 hr prior to the first electrical stimulation for the sevoflurane MAC-BAR determination. The sevoflurane MAC-BAR was significantly reduced by maropitant alone (2.88 +/- 0.73%, P=0.010), carprofen alone (2.96 +/- 0.38%, P=0.016) and the combination (2.81 +/- 0.51%, P=0.0003), compared with saline (3.37 +/- 0.56%). There was no significant difference in the percentage of MAC-BAR reductions between maropitant alone, carprofen alone and the combination. The administration of maropitant alone and carprofen alone produced clinically significant sparing effects on the sevoflurane MAC-BAR in dogs. However, the combination of maropitant and carprofen did not produce any additive effect on the sevoflurane MAC-BAR reduction. Anesthetic premedication with a combination of maropitant and carprofen may not provide any further sparing effect on anesthetic requirement in dogs.
  • Jun Tamura, Tomohito Ishizuka, Sho Fukui, Norihiko Oyama, Kodai Kawase, Takaharu Itami, Kenjiro Miyoshi, Tadashi Sano, Kirby Pasloske, Kazuto Yamashita
    JOURNAL OF VETERINARY MEDICAL SCIENCE 77 8 897 - 904 2015年08月 [査読有り][通常論文]
     
    The sedative effects of intramuscular (IM) alfaxalone in 2-hydroxypropyl-beta-cyclodextrin (alfaxalone-HPCD) were evaluated in cats. The cats were treated with alfaxalone-HPCD in five occasions with a minimum 14-day interval between treatments: an IM injection of 1.0 mg/kg (IM1), 2.5 mg/kg (IM2.5), 5 mg/kg (IM5) or 10 mg/kg (1M10), or an intravenous injection of 5 mg/kg (IV5). The sedative effects were evaluated subjectively using a composite measurement scoring system (a maximum score of 16). Cardio-respiratory variables were measured non-invasively. The median sedation scores peaked at 10 min (score 9), 15 min (score 14), 10 min (score 16), 10 to 20 min (score 16) and 2 to 5 min (score 16) after the IM1, IM2.5, IM5, IM10 and IV5 treatments, respectively. The IM5 treatment produced longer lasting sedation, compared to the IV5 treatment. Durations of maintenance of lateral recumbency after the IM10 treatment (115 +/- 22 min) were longer than those after the IM2.5 (40 +/- 15 min), IM5 (76 +/- 21 min) and IV5 treatments (50 +/- 5 min). Cardio-respiratory variables remained within clinically acceptable ranges, except for each one cat that showed hypotension (<60 mmHg) after the IM10 and IV5 treatments. Tremors, ataxia and opisthotonus-like posture were observed during the early recovery period after the IM2.5, IM5, IM10 and IV5 treatments. In conclusion, IM alfaxalone-HPCD produced dose-dependent and clinically relevant sedative effect at 2.5 to 10 mg/kg in healthy cats. Hypotension may occur at higher IM doses of alfaxalone-HPCD.
  • Jun Tamura, Tomohito Ishizuka, Sho Fukui, Norihiko Oyama, Kodai Kawase, Kenjiro Miyoshi, Tadashi Sano, Kirby Pasloske, Kazuto Yamashita
    JOURNAL OF VETERINARY MEDICAL SCIENCE 77 3 289 - 296 2015年03月 [査読有り][通常論文]
     
    The pharmacological effects of the anesthetic alfaxalone were evaluated after intramuscular (IM) administration to 6 healthy beagle dogs. The dogs received three IM doses each of alfaxalone at increasing dose rates of 5 mg/kg (IM5), 7.5 mg/kg (IM7.5) and 10 mg/kg (IM10) every other day. Anesthetic effect was subjectively evaluated by using an ordinal scoring system to determine the degree of neuro-depression and the quality of anesthetic induction and recovery from anesthesia. Cardiorespiratory variables were measured using noninvasive methods. Alfaxalone administered IM produced dose-dependent neuro-depression and lateral recumbency (i.e., 36 +/- 28 mm, 87 +/- 26 mm and 115 +/- 29 mm after the IM5, IM7.5 and IM10 treatments, respectively). The endotracheal tube was tolerated in all dogs for 46 +/- 20 and 58 +/- 21 mm after the IM7.5 and IM10 treatments, respectively. It was not possible to place endotracheal tubes in 5 of the 6 dogs after the IM5 treatment. Most cardiorespiratory variables remained within clinically acceptable ranges, but hypoxemia was observed by pulse oximetry for 5 to 10 mm in 2 dogs receiving the IM10 treatment. Dose-dependent decreases in rectal temperature, respiratory rate and arterial blood pressure also occurred. The quality of recovery was considered satisfactory in all dogs receiving each treatment; all the dog exhibited transient muscular tremors and staggering gait. In conclusion, IM alfaxalone produced a dose-dependent anesthetic effect with relatively mild cardiorespiratory depression in dogs. However, hypoxemia may occur at higher IM doses of alfaxalone.
  • Jun Tamura, Takaharu Itami, Tomohito Ishizuka, Sho Fukui, Norihiko Ooyama, Kenjiro Miyoshi, Tadashi Sano, Kazuto Yamashita
    JOURNAL OF VETERINARY MEDICAL SCIENCE 76 1 113 - 117 2014年01月 [査読有り][通常論文]
     
    Robenacoxib is a newer nonsteroidal anti-inflammatory drug approved for dogs and cats. This study was designed to evaluate the effect of robenacoxib on the minimum alveolar concentration for blunting adrenergic response (MAC-BAR) of sevoflurane in dogs. Sevoflurane MAC-BAR was determined by judging dogs' response to a noxious electrical stimulus (50 V, 50 Hz and 10 msec) for 10 sec in 6 beagle dogs on two occasions at least a 7-day interval. In each occasion, saline (0.1 ml/kg) or robenacoxib (2 mg/kg) was administered subcutaneously at 1 hr prior to the MAC-BAR determination. Robenacoxib significantly decreased the sevoflurane MAC-BAR (3.44 +/- 0.53% for saline vs. 2.84 +/- 0.38% for robenacoxib, P=0.039). These results suggest that subcutaneous robenacoxib provides a clinically relevant sparing effect on anesthetic requirement.
  • 伊丹 貴晴, 熊本 奈津子, 石塚 友人, 田村 純, 福井 翔, 大山 紀彦, 川瀬 広大, 三好 健二郎, 佐野 忠士, 上野 博史, 泉澤 康晴, 山下 和人
    獣医麻酔外科学雑誌 44 3 23 - 30 Japanese Society of Veterinary Anesthesia & Surgery 2013年 [査読無し][通常論文]
     
    犬の片側椎弓切除術にモルヒネ0.2 mg/kg/時間-リドカイン3 mg/kg/時間-ケタミン0.6 mg/kg/時間の持続静脈内投与(MLK-CRI)によるマルチモーダル術中鎮痛法を臨床応用した。MLK-CRIによって、顕著な循環抑制を生じることなくセボフルランの麻酔要求量約27%まで減少できたが(p<0.05)、調節呼吸の必要性が高く、抜管時間が延長した。MLK-CRIは犬臨床例に有用であるが、呼吸管理と麻酔回復の延長に注意が必要であると考えられた。

その他活動・業績



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