研究者データベース

MAKANAHALLI MADEGOWDA MAHADEVA SWAMY(マカナハリ マデゴウダ マハデバ スワミイ)
先端生命科学研究院
助教

基本情報

所属

  • 先端生命科学研究院

職名

  • 助教

科研費研究者番号

  • 60830031

ORCID ID

J-Global ID

研究キーワード

  • Organic synthesis   Fluorescent probes   Molecular imaging   Sphingolipids   Natural products   

研究分野

  • ライフサイエンス / 生物有機化学

担当教育組織

職歴

  • 2022年04月 - 現在 Visiting scientist, RIKEN
  • 2022年03月 - 現在 Assistant professor, Faculty of Advanced Life Science, Hokkaido University
  • 2019年04月 - 2022年02月 Research scientist, RIKEN
  • 2018年05月 - 2019年01月 Academic researcher, Hokkaido University
  • 2012年05月 - 2014年08月 Research assistant, JNCASR

学歴

  • 2014年10月 - 2018年03月   Doctoral degree, Graduate School of Life Science, Hokkaido University
  • 2009年07月 - 2011年06月   Master's degree, University of Mysore
  • 2006年06月 - 2009年05月   Bachelor's degree, University of Mysore

研究活動情報

論文

  • Mahadeva M. M. Swamy, Yuta Murai, Kenji Monde, Setsuko Tsuboi, Aravind K. Swamy, Takashi Jin
    ACS Applied Materials & Interfaces 16 17253 - 17266 2024年04月01日 [査読有り]
  • Stereochemistry‐activity relationship of ceramide‐induced exosome production to clear amyloid‐β in Alzheimer's disease
    Mariam Abdelrasoul, Kohei Yuyama, Mahadeva M. M. Swamy, Yuta Murai, Kenji Monde
    Chirality 35 9 577 - 585 2023年04月 [査読有り]
  • Sajeer Koolath, Yuta Murai, Tomoya Suzuki, Mahadeva M, M. Swamy, Seigo Usuki, Kenji Monde
    ACS Med. Chem. Lett. in press 9 1237 - 1241 2023年 [査読有り]
  • A near-infrared fluorescent long-chain fatty acid toward optical imaging of cardiac metabolism in living mice
    Mahadeva M. M. Swamy, Mohamad Zarif Mohd, Zubir, Mutmainah, Setsuko Tsuboi, Yuta Murai, Kenji Monde, Ken-ichi Hiranoc, Takashi Jin
    Analyst 147 19 4206 - 4212 2022年08月 [査読有り]
  • Shortwave-infrared (SWIR) emitting annexin V for high-contrast fluorescence molecular imaging of tumor apoptosis in living mice
    Mahadeva M. M. Swamy, Setsuko Tsuboi, Yuta Murai, Kenji Monde, Takashi Jin
    RSC Advances 12 30 19632 - 19639 2022年06月 [査読有り]
  • Mahadeva M. M. Swamy, Yuta Murai, Kenji Monde, Setsuko Tsuboi, Takashi Jin
    Bioconjugate Chemistry 32 8 1541 - 1547 2021年08月18日 [査読有り]
     
    Recently, shortwave-infrared (SWIR) fluorescence imaging for the optical diagnostics of diseases has attracted much attention as a new noninvasive imaging modality. For this application, the development of SWIR molecular imaging probes with high biocompatibility is crucial. Although many types of biocompatible SWIR fluorescent probes based on organic dyes have been reported, there are no SWIR-emitting molecular imaging probes that can be used for the detection of specific biomolecules in vivo. To apply SWIR-emitting molecular imaging probes to biomedical fields, we developed a biocompatible SWIR fluorescent dye based on π-conjugation extended indocyanine green (ICG), where ICG is the only approved near-infrared dye by the US Food and Drug Administration (FDA) for use in the clinic. Using the π-conjugation extended ICG, we prepared SWIR molecular imaging probes that can be used for in vivo tumor imaging. Herein, we demonstrate noninvasive SWIR fluorescence imaging of human epidermal growth factor receptor 2 (HER2)-positive and epidermal growth factor receptor (EGFR)-positive breast tumors using π-conjugation extended ICG and monoclonal antibody conjugates. The presented π-conjugation extended ICG analog probes will be a breakthrough to apply SWIR fluorescence imaging in biomedical fields.
  • Daurichromenic acid from the Chinese traditional medicinal plant Rhododendron dauricum inhibits sphingomyelin synthase and Aβ aggregation
    Hadya Virupaksha Deepak, Mahadeva M. M. Swamy, Yuta Murai, Yoshiko Suga, Masaki Anetai, Takuro Yo, Masahiro Kuragano, Koji Uwai, Kiyotaka Tokuraku, Kenji Monde
    Molecules 25 18 4077 - 4088 2020年09月07日 [査読有り]
  • Determination of the absolute configurations and sensory properties of the enantiomers of a homologous series (C6-C10) of 2-mercapto-4-alkanones
    Christiane Kiske, Anja Devenie Riegel, Ronja Hopf, Anna Kvind, Iulia Poplacean, Tohru Taniguchi, Mahadeva M. M. Swamy, Kenji Monde, Wolfgang Eisenreich, Karl-Heinz Engel
    J. Agric. Food Chem. 64 4 1187 - 1196 2019年01月03日 [査読有り]
  • Structure-inspired design of a sphingolipid mimic sphingosine-1-phosphate receptor agonist from a naturally occurring sphingomyelin synthase inhibitor
    Mahadeva M. M. Swamy, Yuta Murai, Yusuke Ohno, Akio Kihara, Susumu Mitsutake, Yasuyuki Igarashi, Jian Yu, Min Yao, Yoshiko Suga, Masaki Anetai, Kenji Monde
    Chem. Commun. 54 90 12758 - 12761 2018年11月08日 [査読有り]
  • Chemical and genetic rescue of an ep300 knockdown model for Rubinstein Taybi Syndrome in zebrafish
    Aswini Babu, Mageshi Kamaraj, Moumita Basu, Debanjan Mukherjee, Shruti Kapoor, Shashi Ranjan, Mahadeva M. M. Swamy, Stephanie Kaypee, Vinod Scaria, Tapas K. Kundu, Chetana Sachidanandan
    Biochim. Biophys. Acta 1864 4 1203 - 1215 2018年04月 [査読有り]
  • Inhibition of histone/lysine acetyltransferase activity kills CoCl2-treated and hypoxia-exposed gastric cancer cells and reduces their invasiveness
    Suvasmita Rath, Lopamudra Das, Shrikant Babanrao Kokate, Nilabh Ghosh, Pragyesh Dixi, Niranjan Rou, Shivaram P. Singh, Subhasis Chattopadhyay, Hassan Ashktorab, Duane T. Smoo, Mahadeva M. M. Swamy, Tapas K. Kundu, Sheila E. Crowe, Asima Bhattacharyya
    Int. J. Biochem. Cell Biol. 82 28 - 40 2017年01月 [査読有り]
  • Reducing molecular flexibility by cyclization for elucidation of absolute configuration by CD calculations: Daurichromenic acid
    Attila Mandi, Mahadeva M. M. Swamy, Tohru Taniguchi, Masaki Anetai, Kenji Monde
    Chirality 28 6 453 - 459 2016年06月 [査読有り]
  • Stereochemistry of a rhododaurichromanic acid derivative
    Mahadeva M. M. Swamy, Attila Mándi, Masaki Anetai, Kenji Monde
    Nat. Prod. Commun. 11 2 193 - 195 2016年02月 [査読有り]
  • Hydrazinobenzoylcurcumin inhibits androgen receptor activity and growth of castration-resistant prostate cancer in mice
    Min Wu, Sahn-Ho Kim, Indrani Datta, Albert Levin, Gregory Dyson, Jing Li, Stephanie Kaypee, Mahadeva M. M. Swamy, Nilesh Gupta, Ho Jeong Kwon, Mani Menon, Tapas K. Kundu, G. Prem-Veer Reddy
    Oncotarget 6 8 6136 - 6150 2015年03月 [査読有り]
  • Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkers
    Feng Li, Muthu K, Shanmugam, Kodappully Sivaraman Siveen, Fan Wang, Tina H. Ong, Ser Yue Loo, Mahadeva M. M. Swamy, Somnath Mandal, Alan Prem Kumar, Boon Cher Goh, Tapas Kundu, Kwang Seok Ahn, Ling Zhi Wang, Kam Man Hui, Gautam Sethi
    Oncotarget 6 7 5147 - 5163 2015年03月 [査読有り]
  • Naphthoquinone-mediated inhibition of lysine acetyltransferase KAT3B/p300, basis for non-toxic inhibitor synthesis
    Mohankrishna Dalvoy Vasudevarao, Pushpak Mizar, Sujata Kumari, Somnath Mandal, Soumik Siddhanta, Mahadeva M. M. Swamy, Stephanie Kaypee, Ravindra C Kodihalli, Amrita Banerjee, Chandrabhas Naryana, Dipak Dasgupta, Tapas K. Kundu
    J. Biol. Chem. 289 11 7702 - 7717 2014年03月 [査読有り]

書籍

  • Garcinol and its role in chronic diseases
    Amit K. Behera, Mahadeva M. M. Swamy, Nagashayana, Tapas K. Kundu 
    Adv. Exp. Med. Biol. 2016年09月

特許

  • 特願2021-041717:Complexes and shortwave-infrared fluorescent probes, manufacturing methods and thereof  2021年
    Jin Takashi, M. M. Mahadeva Swamy, Monde Kenji, Murai Yuta  RIKEN, Hokkaido University
  • 特願2017-236847:Daurichromenic acid, naturally occurring SMS inhibitor  2017年
    Monde Kenji, Murai Yuta, M. M. Mahadeva Swamy  Hokkaido University
  • 特願2017-236846:Ginkgolic acid, naturally occurring SMS inhibitor  2017年
    Monde Kenji, Murai Yuta, M. M. Mahadeva Swamy  Hokkaido University

受賞

  • 2021年10月 Best poster award RIKEN BDR retreat-2021
  • 2018年10月 Japan Student Services Organization (JASSO) scholarship award
  • 2014年10月 Japan government MEXT scholarship award


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