研究者情報

マスター

アカウント（マスター）

• 氏名

  池辺　洋平(イケベ　ヨウヘイ), イケベ　ヨウヘイ

所属（マスター）

• 医学研究院

所属（マスター）

• 医学研究院

researchmap

プロフィール情報

所属

• 北海道大学, 特任助教

学位

• 博士（医学）（2021年03月 長崎大学）

プロフィール情報

• 姓

  池辺, イケベ

• 名

  洋平, ヨウヘイ

• ID各種

  202201001293813237

所属

• 北海道大学, 特任助教

業績リスト

研究キーワード

• 死後画像診断   神経放射線診断 CT MRI   

研究分野

• ライフサイエンス / 放射線科学 / 神経放射線診断 CT MRI

受賞

• 2022年12月 北米放射線学会 Certificate of Merit
   Pearls and Pitfalls in postmortem imaging: Dead Men Do Tell Tales

論文

• Accelerating FLAIR imaging via deep learning reconstruction: potential for evaluating white matter hyperintensities.

  Noriko Nishioka, Yukie Shimizu, Yukio Kaneko, Toru Shirai, Atsuro Suzuki, Tomoki Amemiya, Hisaaki Ochi, Yoshitaka Bito, Masahiro Takizawa, Yohei Ikebe, Hiroyuki Kameda, Taisuke Harada, Noriyuki Fujima, Kohsuke Kudo

  Japanese journal of radiology 2024年09月24日 

  PURPOSE: To evaluate deep learning-reconstructed (DLR)-fluid-attenuated inversion recovery (FLAIR) images generated from undersampled data, compare them with fully sampled and rapidly acquired FLAIR images, and assess their potential for white matter hyperintensity evaluation. MATERIALS AND METHODS: We examined 30 patients with white matter hyperintensities, obtaining fully sampled FLAIR images (standard FLAIR, std-FLAIR). We created accelerated FLAIR (acc-FLAIR) images using one-third of the fully sampled data and applied deep learning to generate DLR-FLAIR images. Three neuroradiologists assessed the quality (amount of noise and gray/white matter contrast) in all three image types. The reproducibility of hyperintensities was evaluated by comparing a subset of 100 hyperintensities in acc-FLAIR and DLR-FLAIR images with those in the std-FLAIR images. Quantitatively, similarities and errors of the entire image and the focused regions on white matter hyperintensities in acc-FLAIR and DLR-FLAIR images were measured against std-FLAIR images using structural similarity index measure (SSIM), regional SSIM, normalized root mean square error (NRMSE), and regional NRMSE values. RESULTS: All three neuroradiologists evaluated DLR-FLAIR as having significantly less noise and higher image quality scores compared with std-FLAIR and acc-FLAIR (p < 0.001). All three neuroradiologists assigned significantly higher frontal lobe gray/white matter visibility scores for DLR-FLAIR than for acc-FLAIR (p < 0.001); two neuroradiologists attributed significantly higher scores for DLR-FLAIR than for std-FLAIR (p < 0.05). Regarding white matter hyperintensities, all three neuroradiologists significantly preferred DLR-FLAIR (p < 0.0001). DLR-FLAIR exhibited higher similarity to std-FLAIR in terms of visibility of the hyperintensities, with 97% of the hyperintensities rated as nearly identical or equivalent. Quantitatively, DLR-FLAIR demonstrated significantly higher SSIM and regional SSIM values than acc-FLAIR, with significantly lower NRMSE and regional NRMSE values (p < 0.0001). CONCLUSIONS: DLR-FLAIR can reduce scan time and generate images of similar quality to std-FLAIR in patients with white matter hyperintensities. Therefore, DLR-FLAIR may serve as an effective method in traditional magnetic resonance imaging protocols.
• Acute onset of constrictive pericarditis due to acute myelomonocytic leukemia: A case and literature review.

  Naoki Kosaka, Takanori Uchiyama, Masahiro Onozawa, Jun Nagai, Jiro Koya, Suguru Ishizaka, Toshiyuki Nagai, Yohei Ikebe, Kenjiro Kato, Zen-Ichi Tanei, Jun Sakakibara-Konishi, Yuta Hasegawa, Hiroyuki Ohigashi, Hideki Goto, Daigo Hashimoto, Hideki Ujiie, Satoshi Hirano, Satoshi Konno, Toshihisa Anzai, Koji Taniguchi, Shinya Tanaka, Takanori Teshima

  Internal medicine (Tokyo, Japan) 2024年04月16日 

  We herein present a fatal case of constrictive pericarditis (CP) due to acute myelomonocytic leukemia (AMML) in a patient who initially complained of an acute onset of chest pain two days after COVID-19 vaccination. An autopsy revealed pericardial infiltration of leukemic cells. CP is rarely associated with leukemia and only 14 cases have been reported in the literature. The etiology of CP in previous reports included leukemic infiltration, graft-versus-host disease, drug-induced, post-radiation, autoimmune, and otherwise unidentified. This case indicates that leukemic infiltration can cause CP and that clinicians should include leukemia in the differential diagnosis of CP.
• Assessment for Carotid Atherosclerotic Plaque Using Vessel Wall Magnetic Resonance Imaging: A Multireader ROC Study to Determine Optimal Sequence for Detecting Vessel Wall Calcification.

  Hideki Ishimaru, Yohei Ikebe, Tsuyoshi Izumo, Hiroshi Imai, Minoru Morikawa, Reiko Ideguchi, Ayano Ishiyama, Hirofumi Koike, Masataka Uetani, Ryo Toya

  Journal of vascular research 61 3 1 - 7 2024年03月28日 

  INTRODUCTION: We aimed to compare conventional vessel wall MR imaging techniques and quantitative susceptibility mapping (QSM) to determine the optimal sequence for detecting carotid artery calcification. METHODS: Twenty-two patients who underwent carotid vessel wall MR imaging and neck CT were enrolled. Four slices of 6-mm sections from the bilateral internal carotid bifurcation were subdivided into 4 segments according to clock position (0-3, 3-6, 6-9, and 9-12) and assessed for calcification. Two blinded radiologists independently reviewed a total of 704 segments and scored the likelihood of calcification using a 5-point scale on spin-echo imaging, FLASH, and QSM. The observer performance for detecting calcification was evaluated by a multireader, multiple-case receiver operating characteristic study. Weighted κ statistics were calculated to assess interobserver agreement. RESULTS: QSM had a mean area under the receiver operating characteristic curve of 0.85, which was significantly higher than that of any other sequence (p < 0.01) and showed substantial interreader agreement (κ = 0.68). A segment with a score of 3-5 was defined as positive, and a segment with a score of 1-2 was defined as negative; the sensitivity and specificity of QSM were 0.75 and 0.87, respectively. CONCLUSION: QSM was the most reliable MR sequence for the detection of plaque calcification.
• Improved image quality in contrast-enhanced 3D-T1 weighted sequence by compressed sensing-based deep-learning reconstruction for the evaluation of head and neck.

  Noriyuki Fujima, Junichi Nakagawa, Yohei Ikebe, Hiroyuki Kameda, Taisuke Harada, Yukie Shimizu, Nayuta Tsushima, Satoshi Kano, Akihiro Homma, Jihun Kwon, Masami Yoneyama, Kohsuke Kudo

  Magnetic resonance imaging 108 111 - 115 2024年02月09日 

  PURPOSE: To assess the utility of deep learning (DL)-based image reconstruction with the combination of compressed sensing (CS) denoising cycle by comparing images reconstructed by conventional CS-based method without DL in fat-suppressed (Fs)-contrast enhanced (CE) three-dimensional (3D) T1-weighted images (T1WIs) of the head and neck. MATERIALS AND METHODS: We retrospectively analyzed the cases of 39 patients who had undergone head and neck Fs-CE 3D T1WI applying reconstructions based on conventional CS and CS augmented by DL, respectively. In the qualitative assessment, we evaluated overall image quality, visualization of anatomical structures, degree of artifacts, lesion conspicuity, and lesion edge sharpness based on a five-point system. In the quantitative assessment, we calculated the signal-to-noise ratios (SNRs) of the lesion and the posterior neck muscle and the contrast-to-noise ratio (CNR) between the lesion and the adjacent muscle. RESULTS: For all items of the qualitative analysis, significantly higher scores were awarded to images with DL-based reconstruction (p < 0.001). In the quantitative analysis, DL-based reconstruction resulted in significantly higher values for both the SNR of lesions (p < 0.001) and posterior neck muscles (p < 0.001). Significantly higher CNRs were also observed in images with DL-based reconstruction (p < 0.001). CONCLUSION: DL-based image reconstruction integrating into the CS-based denoising cycle offered superior image quality compared to the conventional CS method. This technique will be useful for the assessment of patients with head and neck disease.
• Improvement of image quality in diffusion-weighted imaging with model-based deep learning reconstruction for evaluations of the head and neck.

  Noriyuki Fujima, Junichi Nakagawa, Hiroyuki Kameda, Yohei Ikebe, Taisuke Harada, Yukie Shimizu, Nayuta Tsushima, Satoshi Kano, Akihiro Homma, Jihun Kwon, Masami Yoneyama, Kohsuke Kudo

  Magma (New York, N.Y.) 37 3 439 - 447 2023年11月21日 

  OBJECTIVES: To investigate the utility of deep learning (DL)-based image reconstruction using a model-based approach in head and neck diffusion-weighted imaging (DWI). MATERIALS AND METHODS: We retrospectively analyzed the cases of 41 patients who underwent head/neck DWI. The DWI in 25 patients demonstrated an untreated lesion. We performed qualitative and quantitative assessments in the DWI analyses with both deep learning (DL)- and conventional parallel imaging (PI)-based reconstructions. For the qualitative assessment, we visually evaluated the overall image quality, soft tissue conspicuity, degree of artifact(s), and lesion conspicuity based on a five-point system. In the quantitative assessment, we measured the signal-to-noise ratio (SNR) of the bilateral parotid glands, submandibular gland, the posterior muscle, and the lesion. We then calculated the contrast-to-noise ratio (CNR) between the lesion and the adjacent muscle. RESULTS: Significant differences were observed in the qualitative analysis between the DWI with PI-based and DL-based reconstructions for all of the evaluation items (p < 0.001). In the quantitative analysis, significant differences in the SNR and CNR between the DWI with PI-based and DL-based reconstructions were observed for all of the evaluation items (p = 0.002 ~ p < 0.001). DISCUSSION: DL-based image reconstruction with the model-based technique effectively provided sufficient image quality in head/neck DWI.
• Prediction of amyloid positron emission tomography positivity using multiple regression analysis of quantitative susceptibility mapping.

  Yohei Ikebe, Ryota Sato, Tomoki Amemiya, Niki Udo, Masaaki Matsushima, Ichiro Yabe, Akinori Yamaguchi, Makoto Sasaki, Masafumi Harada, Noriyuki Matsukawa, Yasuo Kawata, Yoshitaka Bito, Toru Shirai, Hisaaki Ochi, Kohsuke Kudo

  Magnetic resonance imaging 103 192 - 197 2023年08月08日 

  PURPOSE: To develop a method for predicting amyloid positron emission tomography (PET) positivity based on multiple regression analysis of quantitative susceptibility mapping (QSM). MATERIALS AND METHODS: This prospective study included 39 patients with suspected dementia from four centers. QSM images were obtained through a 3-T, three-dimensional radiofrequency-spoiled gradient-echo sequence with multiple echoes. The cortical standard uptake value ratio (SUVR) was obtained using amyloid PET with 18F-flutemetamol, and susceptibility in the brain regions was obtained using QSM. A multiple regression model to predict cortical SUVR was constructed based on susceptibilities in multiple brain regions, with the constraint that cortical SUVR and susceptibility were positively correlated. The discrimination performance of the Aβ-positive and Aβ-negative cohorts was evaluated based on the predicted SUVR using the area under the receiver operating characteristic curve (AUC) and Mann-Whitney U test. RESULTS: The correlation coefficients between true and predicted SUVR were increased by incorporating the constraint, and the AUC to discriminate between the Aβ-positive and Aβ-negative cohorts reached to 0.79 (p < 0.01). CONCLUSION: These preliminary results suggest that a QSM-based multiple regression model can predict amyloid PET positivity with fair accuracy.
• Fatal case of subdural empyema caused by Campylobacter rectus and Slackia exigua.

  Yuki Munekata, Saki Yamamoto, Shun Kato, Yutaro Kitagawa, Ken Enda, Nanase Okazaki, Satoshi Tanikawa, Zen-Ichi Tanei, Yohei Ikebe, Takahiro Osawa, Soichiro Takamiya, Hideki Ujiie, Masahiro Onozawa, Satoshi Hirano, Miki Fujimura, Shinya Tanaka

  Autopsy & case reports 13 e2023433  2023年 

  We report a fatal subdural empyema caused by Campylobacter rectus in a 66-year-old female who developed acute onset of confusion, dysarthria, and paresis in her left extremities. A CT scan showed hypodensity in a crescentic formation with a mild mid-line shift. She had a bruise on her forehead caused by a fall several days before admission, which initially raised subdural hematoma (SDH) diagnosis, and a burr hole procedure was planned. However, her condition deteriorated on the admission night, and she died before dawn. An autopsy revealed that she had subdural empyema (SDE) caused by Campylobacter rectus and Slackia exigua. Both microorganisms are oral microorganisms that rarely cause extra-oral infection. In our case, head trauma caused a skull bone fracture, and sinus infection might have expanded to the subdural space causing SDE. CT/MRI findings were not typical for either SDH or SDE. Early recognition of subdural empyema and prompt initiation of treatment with antibiotics and surgical drainage is essential for cases of SDE. We present our case and a review of four reported cases.
• Utility of the deep learning technique for the diagnosis of orbital invasion on CT in patients with a nasal or sinonasal tumor.

  Junichi Nakagawa, Noriyuki Fujima, Kenji Hirata, Minghui Tang, Satonori Tsuneta, Jun Suzuki, Taisuke Harada, Yohei Ikebe, Akihiro Homma, Satoshi Kano, Kazuyuki Minowa, Kohsuke Kudo

  Cancer imaging : the official publication of the International Cancer Imaging Society 22 1 52 - 52 2022年09月22日 

  BACKGROUND: In nasal or sinonasal tumors, orbital invasion beyond periorbita by the tumor is one of the important criteria in the selection of the surgical procedure. We investigated the usefulness of the convolutional neural network (CNN)-based deep learning technique for the diagnosis of orbital invasion, using computed tomography (CT) images. METHODS: A total of 168 lesions with malignant nasal or sinonasal tumors were divided into a training dataset (n = 119) and a test dataset (n = 49). The final diagnosis (invasion-positive or -negative) was determined by experienced radiologists who carefully reviewed all of the CT images. In a CNN-based deep learning analysis, a slice of the square target region that included the orbital bone wall was extracted and fed into a deep-learning training session to create a diagnostic model using transfer learning with the Visual Geometry Group 16 (VGG16) model. The test dataset was subsequently tested in CNN-based diagnostic models and by two other radiologists who were not specialized in head and neck radiology. At approx. 2 months after the first reading session, two radiologists again reviewed all of the images in the test dataset, referring to the diagnoses provided by the trained CNN-based diagnostic model. RESULTS: The diagnostic accuracy was 0.92 by the CNN-based diagnostic models, whereas the diagnostic accuracies by the two radiologists at the first reading session were 0.49 and 0.45, respectively. In the second reading session by two radiologists (diagnosing with the assistance by the CNN-based diagnostic model), marked elevations of the diagnostic accuracy were observed (0.94 and 1.00, respectively). CONCLUSION: The CNN-based deep learning technique can be a useful support tool in assessing the presence of orbital invasion on CT images, especially for non-specialized radiologists.
• Significance of Low Signal in Intracranial Vertebral Artery Wall Observed on Susceptibility-Weighted Angiography.

  Hideki Ishimaru, Yohei Ikebe, Minoru Morikawa, Reiko Ideguchi, Yohei Tateishi, Akira Tsujino, Masataka Uetani

  Cerebrovascular diseases (Basel, Switzerland) 52 1 1 - 8 2022年07月06日 

  PURPOSE: We aimed to investigate the clinical significance of the low signal in the intracranial vertebral artery wall observed on susceptibility-weighted angiography. MATERIALS AND METHODS: We retrospectively reviewed susceptibility-weighted angiographies from 200 consecutive patients with acute ischemic stroke in the posterior circulation territory. The presence of eccentric or concentric low signals in the vertebral artery wall was examined and evaluated. The etiology of the low signal was also investigated as much as possible by referring to computed tomography and T1-weighted imaging (T1WI). We also compared its frequency in each stroke subtype. RESULTS: A low signal was observed in 128/200 patients (64%). The low signals (58%) corresponded to vessel wall calcification in 74 of 128 patients and to vessel wall thickening showing intermediate to low (n = 8) or high (n = 16) signals on T1WI in 24 (19%) patients. The low signal did not have vessel wall thickening or calcification in 1 patient, and the cause of the low signal could not be verified in 29 patients. According to stroke subtypes, a low signal was observed in 14/14 (100%) vertebral artery dissections, all of which corresponded to intramural hematoma. A low signal was observed in 51/65 (78%) atherothromboses, which were significantly more frequent than cardioembolism (34/66; 52%) and small-artery disease (18/39; 46%) (p < 0.01). In atherothrombosis, calcification was the most common cause of low signal (n = 32; 63%). CONCLUSION: Low signals on susceptibility-weighted angiography were frequently observed in vertebral artery dissection and atherothrombosis, reflecting intramural hematoma in all of the former and predominantly calcification in the latter.
• Quantitative Susceptibility Mapping: Basic Methods and Clinical Applications.

  Taisuke Harada, Kohsuke Kudo, Noriyuki Fujima, Masato Yoshikawa, Yohei Ikebe, Ryota Sato, Toru Shirai, Yoshitaka Bito, Ikuko Uwano, Mari Miyata

  Radiographics : a review publication of the Radiological Society of North America, Inc 42 4 1161 - 1176 2022年 

  Quantitative susceptibility mapping (QSM), one of the advanced MRI techniques for evaluating magnetic susceptibility, offers precise quantitative measurements of spatial distributions of magnetic susceptibility. Magnetic susceptibility describes the magnetizability of a material to an applied magnetic field and is a substance-specific value. Recently, QSM has been widely used to estimate various levels of substances in the brain, including iron, hemosiderin, and deoxyhemoglobin (paramagnetism), as well as calcification (diamagnetism). By visualizing iron distribution in the brain, it is possible to identify anatomic structures that are not evident on conventional images and to evaluate various neurodegenerative diseases. It has been challenging to apply QSM in areas outside the brain because of motion artifacts from respiration and heartbeats, as well as the presence of fat, which has a different frequency to the proton. In this review, the authors provide a brief overview of the theoretical background and analyze methods of converting MRI phase images to QSM. Moreover, we provide an overview of the current clinical applications of QSM. Online supplemental material is available for this article. ©RSNA, 2022.
• FDG-PET vs. chemical shift MR imaging in differentiating intertrabecular metastasis from hematopoietic bone marrow hyperplasia.

  Nozomi Oki, Yohei Ikebe, Hirofumi Koike, Reiko Ideguchi, Daisuke Niino, Masataka Uetani

  Japanese journal of radiology 39 11 1077 - 1085 2021年11月 

  PURPOSE: To evaluate the utility of SUVmax on FDG-PET and chemical shift imaging (CSI) on MRI in the differentiation of intertrabecular metastasis (ITM) from hematopoietic bone marrow hyperplasia (HBMH). PATIENTS AND METHODS: We retrospectively evaluated 54 indeterminate focal bone marrow lesions in 44 patients detected on FDG-PET. The lesions were assigned to the metastasis group (M group, 29 lesions of 24 patients) and the non-metastasis group (non-M group, 25 lesions of 20 patients) based on the follow-up or the histopathological studies. The lesions were assessed with the maximum standardized uptake value (SUVmax) on FDG-PET CT images and signal change ratio (SCR) on CSI. RESULTS: The median SUVmax were 5.62 and 2.91; the median SCR were - 0.08 and - 34.8 in M and non-M groups respectively, with significant difference (p < 0.001). With ROC curve analysis, the optimal cutoff value of SUVmax was 4.48 with a sensitivity of 72.4%, a specificity of 100%, and AUC of 0.905. The cutoff value of SCR was - 6.15 with a sensitivity of 82.8%, a specificity of 80%, and AUC of 0.818. CONCLUSION: FDG-PET and CSI on MRI are useful in distinguishing ITM from HBMH. Though their sensitivities are similar, the specificity of FDG-PET was higher than that of MRI.
• Quantitative Susceptibility Mapping for Carotid Atherosclerotic Plaques: A Pilot Study.

  Yohei Ikebe, Hideki Ishimaru, Hiroshi Imai, Kuniko Abe, Tsuyoshi Izumo, Yoichi Morofuji, Reiko Ideguchi, Minoru Morikawa, Masataka Uetani

  Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine 19 2 135 - 140 2020年05月01日 

  PURPOSE: Identifying plaque components such as intraplaque hemorrhage, lipid rich necrosis, and calcification is important to evaluate vulnerability of carotid atherosclerotic plaque; however, conventional vessel wall MR imaging may fail to discriminate plaque components. We aimed to evaluate the components of plaques using quantitative susceptibility mapping (QSM), a newly developed post-processing technique to provide voxel-based quantitative susceptibilities. METHODS: Seven patients scheduled for carotid endarterectomy were enrolled. Magnitude and phase images of five-echo 3D fast low angle shot (FLASH) were obtained using a 3T MRI, and QSM was calculated from the phase images. Conventional carotid vessel wall images (black-blood T1-weighted images [T1WI], T2-weighted images [T2WI], proton-density weighted images [PDWI], and time-of-flight images [TOF]) were also obtained. Pathological findings including intraplaque hemorrhage, calcification, and lipid rich necrosis at the thickest plaque section were correlated with relative susceptibility values with respect to the sternocleidomastoid muscle on QSM. On conventional vessel wall images, the contrast-noise ratio (CNR) between the three components and sternocleidomastoid muscle was measured respectively. Wilcoxon signed-rank test analyses were performed to assess the relative susceptibility values and CNR. RESULTS: Pathologically, lipid rich necrosis was proved in all of seven cases, and intraplaque hemorrhage in five of seven cases. Mean relative susceptibility value of hemorrhage was higher than lipid rich necrosis unexceptionally (P = 0.0313). There were no significant differences between CNR of hemorrhage and lipid rich necrosis on all sequences. In all six cases with plaque calcification, susceptibility value of calcification was significantly lower than lipid rich necrosis unexceptionally (P = 0.0156). There were significant differences between CNRs of lipid rich necrosis and calcification on T1WI, PDWI, TOF (P < 0.05). CONCLUSION: QSM of carotid plaque would provide a novel quantitative MRI contrast that enables reliable differentiation among intraplaque hemorrhage, lipid rich necrosis, and calcification, and be useful to identify vulnerable plaques.
• Cerebral lipiodol embolism related to a vascular lake during chemoembolization in hepatocellular carcinoma: A case report and review of the literature.

  Hideki Ishimaru, Minoru Morikawa, Takayuki Sakugawa, Ichiro Sakamoto, Yasuhide Motoyoshi, Yohei Ikebe, Masataka Uetani

  World journal of gastroenterology 24 37 4291 - 4296 2018年10月07日 

  A male patient underwent conventional transcatheter chemoembolization for advanced recurrent hepatocellular carcinoma (HCC). Even after the injection of 7 mL of lipiodol followed by gelatin sponge particles, the flow of feeding arteries did not slow down. A repeat angiography revealed a newly developed vascular lake draining into systemic veins; however, embolization was continued without taking noticing of the vascular lake. The patient's level of consciousness deteriorated immediately after the procedure, and non-contrast computed tomography revealed pulmonary and cerebral lipiodol embolisms. The patient's level of consciousness gradually improved after 8 wk in intensive care. In this case, a vascular lake emerged during chemoembolization and drained into systemic veins, offering a pathway carrying lipiodol to pulmonary vessels, the most likely cause of this serious complication. We should be aware that vascular lakes in HCC may drain into systemic veins and can cause intratumoral arteriovenous shunts.
• Tumor Emboli from Aortic Metastasis.

  Yohei Ikebe, Eijun Sueyoshi, Hideki Ishimaru, Masaaki Hidaka

  Internal medicine (Tokyo, Japan) 57 6 907 - 908 2018年03月15日

MISC

• 続General Radiology診断演習 "鳥の目"で診断する

  池辺 洋平 画像診断 44 (10) 1087 -1089 2024年08月
• 【画像検査を使いこなす-放射線科医からの贈り物】(第III部)各疾患の画像診断 内分泌系 下垂体腫瘤

  池辺 洋平, 工藤 與亮 日本医師会雑誌 153 (特別1) S208 -S209 2024年06月
• MELASに類似した脳卒中様発作を生じた神経核内封入体病の1例

  亀田 浩之, 原田 太以佑, 藤間 憲幸, 清水 幸衣, 池辺 洋平, 平田 健司, 矢部 一郎, 工藤 與亮 北海道放射線医学雑誌 4 20 -24 2024年03月 

  症例は70歳代女性。約5年前に脳炎・脳症症状のため受診し、皮膚・直腸生検にて神経核内封入体病と診断された。今回、左上下肢麻痺で当院救急搬送となった。入院時の頭部MRIでは、拡散強調画像で右頭頂後頭葉から側頭葉の皮質下白質に高信号が出現した。MRAでは右中・後大脳動脈に拡張所見を認めた。ASLと脳血流IMP-SPECTでは、右頭頂後頭葉から側頭葉にかけて広範な過灌流を認め、造影MRIでは同領域の皮質に沿った増強効果を認めた。痙攣後脳症とNIIDに伴うMELAS様の急性脳症が鑑別疾患に挙がったが、拡散強調像での皮髄境界優位の分布と大脳皮質の増強効果、ステロイドパルス療法後の臨床症状や画像所見の経過から、MELAS様の急性脳症を呈したNIIDと診断した。NIIDの症状は多彩であるが、一部の患者でMELASに類似した臨床症状と画像所見を示す症例が近年報告されており、NIID患者の脳卒中様の発症様式とその画像所見の特徴を知っておく必要がある。(著者抄録)
• 内耳に造影効果を認めたCogan症候群の1例

  小市 裕太, 池辺 洋平, 藤間 憲幸, 亀田 浩之, 原田 太以佑, 清水 幸衣, 工藤 與亮, 竹崎 俊一郎, 藤原 圭志 Japanese Journal of Radiology 42 (Suppl.) 4 -4 2024年02月
• Sunburst appearanceを呈する頭蓋骨腫瘤を契機に発見された神経芽腫の1例

  北川 悠, 竹中 淳規, 渡邊 史郎, 平田 健司, 内山 裕子, 木村 理奈, 中川 純一, 池辺 洋平, 工藤 與亮, 長谷河 昌孝, 澤井 彩織, 寺下 友佳代, 杉山 未奈子, 平林 真介, 長 祐子, 真部 淳 Japanese Journal of Radiology 42 (Suppl.) 5 -5 2024年02月
• 無症候性で診断しえたCarotid webの1例

  池辺洋平, 原田太以佑, 藤間憲幸, 清水幸衣, 亀田浩之, 杉山拓, 工藤與亮 日本脳神経CI学会総会プログラム・抄録集 47th 2024年
• 【全身の血栓症・塞栓症を考える】脳静脈血栓症

  池辺 洋平, 原田 太以佑, 工藤 與亮 画像診断 43 (14) 1371 -1378 2023年11月 

  ＜文献概要＞Point ●脳静脈血栓症の診断は,血栓の同定に加え,脳実質の変化を正確に評価することが重要である.●脳静脈血栓は非造影CT/MRIでも同定できるが,様々な要因で偽陽性・偽陰性となることがあり,正確な診断には造影CT/MRIが望ましい.●脳実質の変化は,動脈支配域に一致しない浮腫・梗塞や,皮質下主体の脳出血が特徴的である.
• 死後画像診断について

  池辺 洋平 断層映像研究会雑誌 50 (1) 31 -31 2023年09月
• Sunburst appearanceを呈する頭蓋骨腫瘤を契機に発見された神経芽腫の1例

  北川 悠, 竹中 淳規, 渡邊 史郎, 平田 健司, 内山 裕子, 木村 理奈, 中川 純一, 池辺 洋平, 長谷河 昌孝, 澤井 彩織, 寺下 友佳代, 杉山 未奈子, 平林 真介, 長 祐子, 山口 秀, 真部 淳, 工藤 與亮 北海道放射線医学雑誌 3 33 -36 2023年03月 

  症例は9歳女児。左頭部腫瘤を主訴に近医を受診し、頭部CTで左前頭骨にsunburst appearanceを呈する腫瘤性病変を指摘され、その他にも右頭頂骨と左下顎頭に骨病変を認めた。体幹部造影CTを施行したところ、後縦隔の胸椎椎体前方から左側にかけて巨大な軟部腫瘤を認めた。血清神経特異エノラーゼ(NSE)や尿中バニリルマンデル酸(VMA)/ホモバニリン酸(HVA)が高値であり、神経芽腫が第一に疑われた。123I-MIBGシンチグラフィを施行したところ、後縦隔腫瘤のほか頭蓋骨を含めた全身骨にも集積が見られ、神経芽腫とその骨転移が疑われた。頭蓋骨腫瘤の生検術により神経芽腫の診断が確定した。神経芽腫は小児期に発生する頭蓋外の固形悪性腫瘍の中で最も頻度が高い。転移性頭蓋骨腫瘍がsunburst appearanceを呈することは比較的稀であるが、小児では神経芽腫の転移でしばしば経験される。神経芽腫の骨転移の部位として、頭蓋骨は頻度が高く、小児においてsunburst appearanceを呈し多発する頭蓋骨腫瘤を見た場合には神経芽腫の骨転移を考慮する必要がある。(著者抄録)
• 放射線科医が触れる死後画像(突然死)中枢神経系領域の死後画像診断-Case review-

  池辺洋平, 池辺洋平, 原田太以佑, 原田太以佑, 工藤與亮, 工藤與亮 臨床画像 39 (11) 1304 -1311 2023年 

  ＜文献概要＞死後画像を適切に評価するためには,死後変化を理解し死後画像としての正常像を踏まえて病態を把握する必要がある。中枢神経領域疾患はしばしば致死的となるが,死後変化と病的所見が紛らわしい場合や病的所見が死因となっているかの判断が難しい場合がある。本稿では病院で遭遇する頻度の高い中枢神経疾患の死後画像を,実際の症例をとおして概説する。
• 全身の血栓症・塞栓症を考える 脳静脈血栓症

  池辺洋平, 池辺洋平, 原田太以佑, 原田太以佑, 原田太以佑, 工藤與亮, 工藤與亮, 工藤與亮 画像診断 43 (14) 1371 -1378 2023年 

  ＜文献概要＞Point ●脳静脈血栓症の診断は,血栓の同定に加え,脳実質の変化を正確に評価することが重要である.●脳静脈血栓は非造影CT/MRIでも同定できるが,様々な要因で偽陽性・偽陰性となることがあり,正確な診断には造影CT/MRIが望ましい.●脳実質の変化は,動脈支配域に一致しない浮腫・梗塞や,皮質下主体の脳出血が特徴的である.
• 似たもの画像、あいまい画像を一刀両断!画像診断道場 実はこうだった(第225回) 病変は1箇所?それとも……

  渡辺 祈一, 池辺 洋平, 工藤 與亮 日本医事新報 (5139) 1 -2 2022年10月
• 頸動脈プラークQSMの画質(artifact)改善のための撮影技術

  川崎 智博, 石坂 欣也, 池辺 洋平, 原田 邦明, 白勢 竜二, 佐藤 良太, 工藤 與亮 北海道放射線技術雑誌 92 (92) 36 -37 2022年04月
• 【これを見つけたら即対応 重要疾患を読影で見きわめる】中枢神経領域

  池辺 洋平, 藤間 憲幸, 工藤 與亮 臨床画像 37 (12) 1390 -1402 2021年12月 

  ＜文献概要＞椎骨動脈解離は種々のシーケンスを用いて解離を同定する必要があり,3D-TSE(turbo spin-echo)法T1強調像やMR cisternographyが有用な場合がある。静脈血栓症は正常例や種々の疾患との鑑別が問題となり,診断確定には造影MRV(MR venography)が有用である。メトロニダゾール脳症は小脳歯状核の異常信号が特徴で,詳細な病歴の確認が重要である。低髄液圧症候群/脳脊髄液漏出症は髄液減少に伴う特徴的な所見を積極的に検索することで診断できる。
• 頸動脈プラークQSMの画質(artifact)改善のための撮影技術

  川崎 智博, 石坂 欣也, 原田 邦明, 池辺 洋平, 工藤 與亮, 白勢 竜二, 佐藤 良太 北海道放射線技術雑誌 91 (91) 56 -56 2021年10月
• 【CTとMRIのサインから読み解く病態・病理II】脳神経領域 脳梗塞・脳出血のサイン

  池辺 洋平, 原田 太以佑 臨床放射線 66 (2) 123 -129 2021年02月
• CASE OF THE MONTH 嗅神経芽細胞腫

  池辺洋平, 上谷雅孝 画像診断 40 (6) 2020年
• 定量的磁化率マッピング取得のためのTEとエコー数の検討

  田川 忍, 稲富 信之, 石丸 英樹, 池辺 洋平, 今井 広 JART: 日本診療放射線技師会誌 66 (9) 1013 -1013 2019年09月
• 定量的磁化率解析を用いた頚動脈プラークの新たな評価法の開発

  池辺洋平 長崎県医師会報 (878) 2019年
• もやもや病血行再建術後評価におけるMRAの有用性

  吉見聡美, 森川実, 石丸英樹, 井手口怜子, 池辺洋平, 堀江信貴, 出雲剛, 上谷雅孝 日本神経放射線学会プログラム・抄録集 48th 2019年
• 上腸間膜動脈塞栓症で発症し、経カテーテル吸引除去した組織で判明した胆管癌大動脈転移の1例

  池辺 洋平, 石丸 英樹, 安井 和明, 赤司 沙織, 上谷 雅孝, 大野 慎一郎, 日高 匡章, 安井 春奈, 木下 直江 Japanese Journal of Radiology 36 (Suppl.) 61 -61 2018年02月
• 肝硬変と門脈血栓に合併した腫瘤状肝梗塞の2例

  大塚 哲洋, 石丸 英樹, 池辺 洋平, 林 秀行, 上谷 雅孝 Japanese Journal of Radiology 36 (Suppl.) 77 -77 2018年02月
• 椎骨動脈壁にSWANで認められる低信号の意義-後方循環脳梗塞例での検討

  石丸英樹, 池辺洋平, 森川実, 井手口怜子, 上谷雅孝 日本神経放射線学会プログラム・抄録集 47th 2018年
• 頸動脈プラークのQSMの経験

  池辺洋平, 石丸英樹, 今井浩, 井手口怜子, 森川実, 出雲剛, 安倍邦子, 上谷雅孝 日本神経放射線学会プログラム・抄録集 47th 2018年
• 腹部大動脈瘤合併、腸骨動静脈瘻に対しステントグラフト治療を行った1例

  池辺 洋平, 鬼塚 浩徳, 末吉 英純, 坂本 一郎, 上谷 雅孝, 川口 祐太朗, 谷川 和好, 江石 清行 IVR: Interventional Radiology 32 (3) 254 -254 2017年10月
• ピーターソンヘルニアの2例

  池辺 洋平, 牧野 謙二, 福田 雅敏, 福井 健一郎, 松本 彩, 荒木 政人 Japanese Journal of Radiology 35 (Suppl.) 81 -81 2017年02月
• 術中開創器圧迫による限局肝損傷

  池辺 洋平, 石丸 英樹, 坂本 綾美, 上谷 雅孝 Japanese Journal of Radiology 35 (Suppl.) 87 -87 2017年02月
• 上腸間膜動脈塞栓症を来した肝内胆管癌大動脈転移の1例

  池辺 洋平, 末吉 英純, 安井 和明, 石丸 英樹, 坂本 一郎, 大野 慎一郎, 日高 匡章, 安井 春奈, 木下 直江, 上谷 雅孝 脈管学 56 (Suppl.) S241 -S242 2016年10月
• 画像から読み解く感染症 上腹部・消化管 Fitz-Hugh-Curtis症候群

  池辺 洋平, 石丸 英樹, 荻野 歩, 上谷 雅孝 化学療法の領域 32 (11) 1950 -1955 2016年10月 [査読無し][通常論文]
   

  Fitz-Hugh-Curtis症候群は骨盤内感染症により引き起こされる限局性の肝周囲炎である。性活動が活発な若い女性が右上腹部や心窩部痛で発症することが多い。Chlamydia trachomatis,Neisseria gonorrhoeaeが起因菌となり急性期に適切な抗菌薬投与を行うことができれば予後良好である。骨盤内の炎症所見がはっきりしないことも多く診断に難渋する場合があるが,造影CTにて特徴的な画像所見を呈し診断に大きく寄与する。肝周囲炎を反映して動脈相にて肝臓に被膜状の造影効果が認められ,臨床所見とあわせて本疾患を考える。(著者抄録)
• 副腎原発骨髄脂肪腫破裂・出血に対してTAEを行った1例

  池辺 洋平, 末吉 英純, 赤司 沙織, 坂本 綾美, 坂本 一郎, 上谷 雅孝, 岩田 隆寿, 望月 保志 IVR: Interventional Radiology 31 (3) 259 -259 2016年08月
• 頭蓋内出血による難治性けいれん発作から診断に至った血友病Bの一例

  池辺 洋平, 内藤 愼二, 宮園 正之, 牧野 謙二, 木村 亜由美, 河部 庸次郎 国立病院総合医学会講演抄録集 68回 903 -903 2014年11月

共同研究・競争的資金等の研究課題

• MRI-R2′による革新的な脳酸素代謝の可視化

  日本学術振興会：科学研究費助成事業 若手研究

  研究期間 : 2022年04月 -2027年03月 

  代表者 : 池辺 洋平