研究者データベース

青島 圭佑(アオシマ ケイスケ)
獣医学研究院 獣医学部門 臨床獣医科学分野
助教

基本情報

所属

  • 獣医学研究院 獣医学部門 臨床獣医科学分野

職名

  • 助教

学位

  • 獣医師(2011年04月 北海道大学)
  • 博士 (獣医学)(2016年03月 北海道大学)
  • 日本獣医病理専門家協会会員(2016年04月)

論文上での記載著者名

  • Keisuke Aoshima

ORCID ID

J-Global ID

研究分野

  • ライフサイエンス / 獣医学 / 獣医病理学
  • ライフサイエンス / 腫瘍生物学 / 血管肉腫
  • ライフサイエンス / 分子生物学 / エピジェネティクス

職歴

  • 2017年04月 - 現在 北海道大学 大学院獣医学研究院 助教
  • 2018年04月 - 2020年05月 Yale School of Medicine, Department of Pathology, Visiting Research Scientist,
  • 2015年11月 - 2017年03月 北海道大学 大学院獣医学研究科 助教
  • 2014年06月 - 2015年10月 北海道大学 大学院獣医学研究科 特任助教
  • 2013年04月 - 2014年06月 北海道大学 大学院獣医学研究科 日本学術振興会特別研究員 DC2

学歴

  • 2011年04月 - 2014年06月   北海道大学   大学院獣医学研究科
  • 2012年02月 - 2014年02月   東京大学   大学院農学生命科学研究科   特別研究学生
  • 2011年06月 - 2012年01月   京都大学   大学院医学研究科   特別研究学生
  • 2005年04月 - 2011年03月   北海道大学   獣医学部

所属学協会

  • 日本獣医病理専門家協会   日本分子生物学会   日本獣医学会   

研究活動情報

論文

  • Kevin Christian Montecillo Gulay, Keisuke Aoshima*, Yuki Shibata, Hironobu Yasui, Qin Yan, Atsushi Kobayashi, Takashi Kimura
    bioRxiv 2020年11月17日 [査読無し][通常論文]
     
    * Corresponding author
  • Meiling Zhang, Zongzhi Z. Liu, Keisuke Aoshima, Yangyi Zhang, Yongyan An, Asako Aoshima, Lok Hei Chan, Sabine M. Lang, Hongyi Sun, Zhenwei Tang, Sara J. Rutter, Carmen J. Booth, Veerle Bossuyt, Xiang Chen, Jon S. Morrow, Lajos Pusztai, David. L. Rimm, Mingzhu Yin, Qin Yan
    bioRxiv Cold Spring Harbor Laboratory 2020年09月10日 [査読無し][通常論文]
  • Ochbayar Erdemsurakh, Khurtsbaatar Ochirbat, Ulziisaikhan Gombosuren, Batbold Tserendorj, Baatarjargal Purevdorj, Batbaatar Vanaabaatar, Keisuke Aoshima, Atsushi Kobayashi, Takashi Kimura
    The Journal of veterinary medical science 2020年07月07日 [査読有り][通常論文]
     
    Glanders is a contagious and fatal equine disease caused by the gram-negative bacterium Burkholderia mallei.B. mallei is prevalent among horse populations in Asia, the Middle East, and South America. More than four million horses have been registered in Mongolia in 2020. However, the resent prevalence of glanders has not been well investigated. In this study, we aimed to investigate the seropositivity of B. mallei in horse populations in Mongolia using the complement fixation test (CFT) and Rose Bengal plate agglutination test (RBT). We randomly collected blood samples from horses in central and eastern Mongolia between 2018 and 2019. Of 337 horses, 26 (7.7%) and 28 (8.3%) were seropositive using RBT and CFT, respectively. Interestingly, seropositivity in horses resulting from crossbreeding of Mongolian native horses with thoroughbred horses was higher than that in Mongolian native horses. Our observations suggest that equine glanders are still endemic to Mongolia.
  • Teita Ishizaki, Jumpei Yamazaki, Shinji Meagawa, Nozomu Yokoyama, Keisuke Aoshima, Mitsuyoshi Takiguchi, Takashi Kimura
    Veterinary and comparative oncology 2020年03月18日 [査読有り][通常論文]
     
    Canine malignant melanoma is a common cancer with a high mortality rate and is a clinically important disease. DNA methylation has been considered to be a potential tumorigenic mechanism through aberrant DNA methylation at promoter region which represses gene transcription. Global hypomethylation could also facilitate chromosome instability. There are few reports regarding DNA methylation in canine malignant melanoma; therefore, the purpose of this study was to examine DNA methylation status of long interspersed nucleotide element-1 (LINE-1) to be a surrogate marker of genome-wide methylation changes in this disease. We measured levels of DNA methylation of two adjacent cytosine-guanine sites on CpG island (CGI) at the putative promoter of canine LINE-1 sequence by bisulphite-pyrosequencing in 41 canine melanoma patient samples as well as six cell lines compared with normal mucosae. The survival rates were obtained from owners or medical records. We found DNA methylation levels of LINE-1 in normal mucosae were methylated. Interestingly, both melanoma cell lines and clinical melanoma samples showed remarkable hypomethylation. In addition, patients with lower LINE-1 methylation showed worse prognosis than those with higher LINE-1 methylation, though the difference did not reach statistical significance (P = .09). Here, we demonstrate that hypomethylation of LINE-1 is an epigenetically aberrant feature in canine melanoma with possible prognostic value.
  • Minato E, Kobayashi A, Aoshima K, Fukushi H, Kimura T
    Microbiol Immunol 64 2 123 - 132 2020年02月 [査読有り][通常論文]
  • Gale M, Li Y, Cao J, Liu ZZ, Holmbeck MA, Zhang M, Lang SM, Wu L, Do Carmo M, Gupta S, Aoshima K, DiGiovanna MP, Stern DF, Rimm DL, Shadel GS, Chen X, Yan Q
    Cancer research 2019年11月 [査読有り][通常論文]
  • Morita A, Aoshima K*, Gulay KCM, Onishi S, Shibata Y, Yasui H, Kobayashi A, Kimura T, *Corresponding author
    Research in veterinary science 127 1 - 10 2019年10月 [査読有り][通常論文]
     
    * Corresponding author
  • Minato E, Aoshima K, Kobayashi A, Ohnishi N, Sasaki N, Kimura T
    Veterinary pathology 56 5 300985819834616 - 710 2019年03月 [査読有り][通常論文]
  • Kobayashi A, Iwasaki Y, Takao M, Saito Y, Iwaki T, Qi Z, Torimoto R, Shimazaki T, Munesue Y, Isoda N, Sawa H, Aoshima K, Kimura T, Kondo H, Mohri S, Kitamoto T
    The American journal of pathology 189 6 1276 - 1283 2019年03月 [査読有り][通常論文]
  • Keisuke Aoshima*, Yuki Fukui, Kevin Christian Montecillo Gulay, Ochbayar Erdemsurakh, Atsuya Morita, Atsushi Kobayashi, Takashi Kimura, *Corresponding author
    BMC Veterinary Research 14 1 301  Springer Nature America, Inc 2018年12月 [査読有り][通常論文]
     
    * Corresponding author
  • Kobayashi A, Qi Z, Shimazaki T, Munesue Y, Miyamoto T, Isoda N, Sawa H, Aoshima K, Kimura T, Mohri S, Kitamoto T, Yamashita T, Miyoshi I
    The American journal of pathology 189 3 677 - 686 2018年12月 [査読有り][通常論文]
  • H.M. Suranji Wijekoon, Sangho Kim, Eugene C. Bwalya, Jing Fang, Keisuke Aoshima, Kenji Hosoya, Masahiro Okumura
    Research in Veterinary Science 122 179 - 185 Elsevier {BV} 2018年12月 [査読有り][通常論文]
  • Raghda M. F. Abbas, Hassan T. Tag-El-Din-Hassan, Tussapon Boonyarattanasoonthorn, Keisuke Aoshima, Masami Morimatsu, Takashi Agui
    Japanese Journal of Veterinary Research 66 2 93 - 103 2018年05月01日 [査読有り][通常論文]
     
    It has been reported that C57BL/6 (B6) mice are resistant to the Sendai virus (SeV) infection, whereas DBA/2 (D2) mice are susceptible, the cause of susceptibility in D2 mice is hyper-inflammatory cytokine production, and three quantitative trait loci (QTLs), Sen1, Sen2, and Sen3 are identified to be responsible for this difference. We previously have verified that the introgression of B6-derived these three QTLs into D2-genetic background increases survival rate and suppresses cytokine production by generating D2.B6-Sen1Sen2Sen3 congenic mice. In this study, we investigated immune cellular responses of D2.B6-Sen1Sen2Sen3 mice after SeV infection. Body weight loss, viral load, immune cells in broncho-alveolar lavage fluid (BALF), and histopathological index of SeV-infected male D2. B6-Sen1Sen2Sen3 mice were comparable to those of B6 mice except for the number of neutrophils in BALF. In contrast, female D2.B6-Sen1Sen2Sen3 mice were divided into survived and non-survived mice after SeV infection. Viral load and macrophage number in BALF in SeV-infected female D2. B6-Sen1Sen2Sen3 mice were comparable to those of B6 mice, whereas the number of total cells, neutrophils, and lymphocytes in BALF were remained in the level of D2 mouse. There was a correlation between body weight loss and these immune cellular responses in SeV-infected female D2.B6-Sen1Sen2Sen3 mice. These results indicate that the introgression of B6 alleles of these three QTLs into D2-genetic background resulted in resistance to SeV infection by optimizing the aggressive immune cellular responses that seen in D2 mice, although there may be other loci responsible for difference between B6 and D2 mice.
  • Yoshiko Munesue, Taishi Shimazaki, Zechen Qi, Norikazu Isoda, Hirofumi Sawa, Keisuke Aoshima, Takashi Kimura, Shirou Mohri, Tetsuyuki Kitamoto, Atsushi Kobayashi
    Neuroscience Letters 668 43 - 47 2018年03月06日 [査読有り][通常論文]
     
    Evaluation of transmission properties is important for the differential diagnosis of a subgroup of acquired Creutzfeldt-Jakob disease (CJD) with methionine homozygosity at polymorphic codon 129 of the PRNP gene, an intermediate type abnormal prion protein (PrP), and kuru plaques, denoted as acquired CJD-MMiK. The present study aimed to develop a quick evaluation system of the transmission properties of acquired CJD-MMiK. In the PrP-humanized mice intraperitoneally inoculated with brain homogenates from an acquired CJD-MMiK patient, accumulation of abnormal PrP was observed in follicular dendritic cells of the spleen at 75 days post-inoculation. The transmission properties of acquired CJD-MMiK were quite different from those of sporadic CJD with the same PRNP codon 129 genotype. Moreover, even at 14 days post-inoculation, the characteristic transmission properties of acquired CJD-MMiK could be detected. These findings suggest that the bioassay using follicular dendritic cells of the spleen, named as a FDC assay, can be an easy, time-saving, and useful method to distinguish acquired CJD-MMiK from sporadic CJD.
  • Aprilia Maharani, Keisuke Aoshima, Shinichi Onishi, Kevin Christian Montecillo Gulay, Atsushi Kobayashi, Takashi Kimura
    Journal of Veterinary Medical Science 80 2 213 - 218 2018年02月01日 [査読有り][通常論文]
     
    Canine hemangiosarcoma (HSA) is one of the most common mesenchymal tumors in dogs. Its high metastatic and growth rates are usually associated with poor prognosis. Neoplastic cells of HSA can show various levels of cellular atypia in the same mass and may consist of various populations at different differentiated stages. Up to present, however, there is no report analyzing their differentiation states by comparing cellular atypia with differentiation-related protein expressions. To evaluate whether cellular atypia can be used as a differentiation marker in HSA, we analyzed correlation between cellular atypia and intensities of CD31 and von Willebrand Factor (vWF) staining in HSA cases. We also compared cellular atypia and expression levels of CD31 and vWF in each growth patterns. Our results show that cellular atypia was negatively correlated to CD31 and vWF expression levels but no significant correlation was found between growth patterns and cellular atypia or CD31 and vWF expression levels. Our study suggests that cellular atypia is useful for identifying differentiation levels in HSA cases. This study also provides useful information to determine differentiation levels of cell populations within HSA based only on morphological analysis, which will aid further HSA research such as identifying undifferentiation markers of endothelial cells or finding undifferentiated cell population in tissue sections.
  • Yusuke Izumi, Keisuke Aoshima, Yuki Hoshino, Satoshi Takagi
    RESEARCH IN VETERINARY SCIENCE 112 222 - 228 2017年06月 [査読有り][通常論文]
     
    Combretastatin A-4 phosphate (CA4P) selectively blocks tumor blood flow. However, the detailed mechanisms through which CA4P specifically affects tumor blood vessels are not well understood. Recent reports revealed that tumor tissue-derived endothelial cells (TECs) have various specific features in comparison with normal tissue-derived endothelial cells (NECs). Thus, abnormalities in TECs may be involved in the selective vascular blockade mechanism of CA4P. In this study, we evaluated the effects of CA4P on canine NECs and TECs using confocal microscopy. NECs exhibited different susceptibilities at subconfluence and at 100% confluence. In addition, inhibition of vascular endothelial cadherin (VE-cadherin) in NECs increased the sensitivity of the cells to CA4P. TECs seemed to be more susceptible to CA4P than NECs. The expression pattern of VE-cadherin in TECs was abnormal compared with that of NECs, suggesting that VE-cadherin may have functional abnormalities in these cells. Taken together, these results indicate that the tumor-vascular selectivity of CA4P may be related to VE-cadherin dysfunction in TECs.
  • Keisuke Aoshima, Takashi Kimura, Yuki Okada
    Methods in Molecular Biology 1605 259 - 270 2017年 [査読有り][通常論文]
     
    Histone modifications are dramatically altered during the pronuclear (PN) stage of zygotes, and more markedly in paternal than maternal pronuclei. Among various types of histone modifications, lysine methylation exhibits the most dynamic changes in the PN stage. To analyze the physiological functions of histone methylations, it is therefore important to elucidate the mechanism of epigenetic reprogramming. However, loss-of-function approaches using mutant histones whose lysine residues have been substituted with arginine residues are unable to erase histone modifications at all levels, since they are incapable of entirely replacing endogenous histones. To solve this problem, we used an alternative histone mutant whose lysine residues were substituted with methionine (K-M mutants). This mutant cannot be methylated itself but also prevents methylation of endogenous histones. We also developed a simple method for analyzing global transcription levels in early preimplantation embryos, involving using a commercial kit to examine the involvement of histone methylation in zygotic gene activation.
  • Yuki Okada, Keisuke Aoshima
    CELL CYCLE 14 16 2541 - 2542 2015年08月 [査読有り][通常論文]
  • Keisuke Aoshima, Erina Inoue, Hirofumi Sawa, Yuki Okada
    EMBO REPORTS 16 7 803 - 812 2015年07月 [査読有り][通常論文]
     
    Epigenetic modifications, such as DNA methylation and histone modifications, are dynamically altered predominantly in paternal pronuclei soon after fertilization. To identify which histone modifications are required for early embryonic development, we utilized histone K-M mutants, which prevent endogenous histone methylation at the mutated site. We prepared four single K-M mutants for histone H3.3, K4M, K9M, K27M, and K36M, and demonstrate that overexpression of H3.3 K4M in embryos before fertilization results in developmental arrest, whereas overexpression after fertilization does not affect the development. Furthermore, loss of H3K4 methylation decreases the level of minor zygotic gene activation (ZGA) predominantly in the paternal pronucleus, and we obtained similar results from knockdown of the H3K4 methyltransferase Mll3/4. We therefore conclude that H3K4 methylation, likely established by Mll3/4 at the early pronuclear stage, is essential for the onset of minor ZGA in the paternal pronucleus, which is necessary for subsequent preimplantation development in mice.
  • Sawang Kesdangsakonwut, Yuji Sunden, Keisuke Aoshima, Yoshimi Iwaki, Masahiro Okumura, Hirofumi Sawa, Takashi Umemura
    NEUROPATHOLOGY 34 3 277 - 283 2014年06月 [査読有り][通常論文]
     
    Rabies is a fatal zoonotic disease for which no effective treatment measures are currently available. Rabies virus (RABV) has anti-apoptotic and anti-inflammatory properties that suppress nerve cell damage and inflammation in the CNS. These features imply that the elimination of RABV from the CNS by appropriate treatment could lead to complete recovery from rabies. Ten rabbits showing neuromuscular symptoms of rabies after subcutaneous (SC) immunization using commercially available vaccine containing inactivated whole RABV particles and subsequent fixed RABV (CVS strain) inoculation into hind limb muscles were allocated into three groups. Three rabbits received no further treatment (the SC group), three rabbits received three additional SC immunizations using the same vaccine, and four rabbits received three intrathecal (IT) immunizations, in which the vaccine was inoculated directly into the cerebrospinal fluid (the SC/IT group). An additional three naive rabbits were inoculated intramuscularly with RABV and not vaccinated. The rabbits exhibited neuromuscular symptoms of rabies within 4-8 days post-inoculation (dpi) of RABV. All of the rabbits died within 8-12 dpi with the exception of one rabbit in the SC group and all four rabbits in SC/IT group, which recovered and started to respond to external stimuli at 11-18 dpi and survived until the end of the experimental period. RABV was eliminated from the CNS of the surviving rabbits. We report here a possible, although still incomplete, therapy for rabies using IT immunization. Our protocol may rescue the life of rabid patients and prompt the future development of novel therapies against rabies.
  • Makino Y, Inoue E, Hada M, Aoshima K, Kitano S, Miyachi H, Okada Y
    Frontiers in cell and developmental biology 2 30  2014年 [査読有り][通常論文]
  • Keisuke Aoshima, Ai Baba, Yoshinori Makino, Yuki Okada
    PLOS ONE 8 10 e77715  2013年10月 [査読有り][通常論文]
     
    Since spermatogonial stem cells (SSCs) are capable of both self-renewal and differentiation to daughter cells for subsequent spermatogenesis, the development of an efficient in vitro culture system is essential for studies related to spermatogenesis. Although the currently available system is serum-free and contains only chemically-defined components, it highly relies upon bovine serum albumin (BSA), a component with batch-to-batch quality variations similar to those of fetal bovine serum. Thus, we searched for an alternative BSA-free culture system that preserved the properties of SSCs. In this study, we utilized Knockout Serum Replacement (KSR) in the SSC culture medium, as a substitute for BSA. The results demonstrated that KSR supported the continuous growth of SSCs in vitro and the SSC activity in vivo without BSA, in a feeder-cell combination with mouse embryonic fibroblasts. The addition of BSA to KSR further facilitated cell cycle progression, whereas a transplantation assay revealed that the addition of BSA did not affect the number of SSCs in vivo. The combination of KSR with BSA also allowed the elimination of GFRA1 and FGF2, and the reduction of the GDNF concentration from 20 ng/ml to 5 ng/ml, while maintaining the growth rate and the expression of SSC markers. Furthermore, KSR was also useful with SSCs from non-DBA/2 strains, such as C57BL/6 and ICR. These results suggested that KSR is an effective substitute for BSA for long-term in vitro cultures of SSCs. Therefore, this method is practical for various studies related to SSCs, including spermatogenesis and germ stem cell biology.
  • Aoshima K, Okada Y
    Seikagaku. The Journal of Japanese Biochemical Society 85 4 278 - 283 4 2013年04月 [査読有り][通常論文]
  • Kensuke Nakamura, Masahiro Yamasaki, Tomohiro Osaki, Hiroshi Ohta, Noboru Sasaki, Keisuke Aoshima, Takashi Kimura, Mitsuyoshi Takiguchi
    JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION 48 5 327 - 330 2012年09月 [査読有り][通常論文]
     
    Bilateral segmental aplasia of the uterine horns with unilateral pyometra and uterine horn torsion were diagnosed in a Pomeranian bitch that presented with chronic abdominal distension and an acute onset of anorexia and lethargy. Because radiographic and ultrasonographic findings revealed the presence of markedly enlarged bilateral uterine horns filled with fluid in the caudal abdomen, a tentative diagnosis of either pyometra or hydrometra with uterine horn torsion was made. Exploratory laparotomy showed bilateral, segmentally distended uterine horns with unilateral uterine horn torsion. Ovariohysterectomy was performed, and bilateral segmental aplasia of the uterine horns with the development of unilateral uterine horn torsion was diagnosed histopathologically. To the authors' knowledge, this is the first report of uterine horn torsion in conjunction with segmental aplasia of the uterine horn in a bitch. (J Am Anim Hosp Assoc 2012; 48:327-330. DOI 10.5326/JAAHA-MS-5771)
  • Keisuke Aoshima, Yuji Sunden, Sachiyo Ishida, Kenji Ochiai, Takashi Umemura
    JOURNAL OF VETERINARY MEDICAL SCIENCE 73 10 1303 - 1308 2011年10月 [査読有り][通常論文]
     
    Intrathecal (IT) immunization involves injecting antigens directly into the intraventricular or subarachnoid spaces, or brain, to induce antigen-specific antibodies (Ab) in the cerebrospinal fluid (CSF). In the present study, rabbits were immunized IT with inactivated rabies virus to investigate the origins of CSF Ab. The time course of Ab induction and tumor necrosis factor-alpha expression suggested the possibility that the CSF Ab originated in the serum. In addition, Ab-producing cells infiltrated around the blood vessels of the brain, suggesting local production of Ab within the central nervous system (CNS). Furthermore, subcutaneous (SC) immunization prior to IT immunization induced a rapid and magnified Ab response in the CSF compared with IT immunization alone. These results were confirmed by the fact that mice immunized SC prior to IT were more resistant to intracerebral challenge with rabies virus than mice immunized via the IT route alone. Taken together, these results suggest that combined SC and IT immunization is a more effective vaccination protocol for prophylaxis and treatment of rabies.

その他活動・業績

  • ドキソルビシン耐性イヌ血管肉腫細胞株の樹立と薬剤耐性機構の解析
    森田 敦也, 青島 圭佑, 小林 篤史, 木村 享史 日本獣医学会学術集会講演要旨集 161 303 -303 2018年08月 [査読無し][通常論文]
  • イヌ血管肉腫におけるCXCR7シグナル伝達機構の解析
    大西 慎一, 青島 圭佑, 小林 篤史, 木村 享史 日本獣医学会学術集会講演要旨集 160 321 -321 2017年08月 [査読無し][通常論文]
  • マウス受精卵前核期におけるクロマチンダイナミクスの解析
    青島 圭佑, 岡田 由紀 日本獣医学会学術集会講演要旨集 156回 370 -370 2013年08月 [査読無し][通常論文]
  • 青島 圭佑, 岡田 由紀 生化学 85 (4) 278 -283 2013年04月 [査読無し][通常論文]
  • Y. Sunden, K. Aoshima, S. Ishida, K. Ochiai, T. Umemura JOURNAL OF COMPARATIVE PATHOLOGY 146 (1) 60 -60 2012年01月 [査読無し][通常論文]

受賞

  • 2014年09月 The 2nd Sapporo Summer Seminar for One Health, Special Award
     
    受賞者: 青島圭佑
  • 2011年03月 日本獣医師会長賞
     
    受賞者: 青島圭佑
  • 2006年06月 北海道大学 新渡戸賞
     
    受賞者: 青島圭佑

共同研究・競争的資金等の研究課題

  • 血管肉腫のエピジェネティクス~KDM2Bの役割の解明とマウスモデルの作製~
    日本学術振興会:科学研究費補助金 若手研究
    研究期間 : 2020年04月 -2022年03月 
    代表者 : 青島圭佑
  • イヌ血管肉腫におけるマウス疾患モデルの作製
    公益財団法人 栗林育英学術財団:研究助成事業
    研究期間 : 2020年09月 -2021年03月
  • イヌ血管肉腫未分化細胞のエピジェネティックな分化制御機構の解明
    日本学術振興会:科学研究費補助金 若手研究
    研究期間 : 2018年04月 -2020年03月 
    代表者 : 青島圭佑
  • 異常血管内皮細胞を制御する~血管肉腫と腫瘍血管の比較病理
    ノーステック財団:「研究開発助成事業」若手研究人材・ネットワーク育成補助金
    研究期間 : 2016年08月 -2017年03月 
    代表者 : 青島圭佑
  • 新規治療標的探索を目的としたイヌ血管肉腫におけるNotchシグナルの役割の解明
    秋山財団:研究助成<奨励>
    研究期間 : 2016年07月 -2017年03月 
    代表者 : 青島圭佑
  • マウス受精卵前核期におけるクロマチンダイナミクスの解析
    日本学術振興会:特別研究員奨励費 DC2
    研究期間 : 2013年04月 -2015年03月 
    代表者 : 青島圭佑

教育活動情報

主要な担当授業

  • アカデミックイングリッシュ
    開講年度 : 2018年
    課程区分 : 博士後期課程
    開講学部 : 国際感染症学院
  • 病理学総論実習
    開講年度 : 2018年
    課程区分 : 学士課程
    開講学部 : 獣医学部
    キーワード : 動物病理学,病理解剖,病理組織学,細胞傷害,細胞・組織の適応,循環障害,炎症,腫瘍
  • アカデミックイングリッシュ
    開講年度 : 2018年
    課程区分 : 博士後期課程
    開講学部 : 獣医学研究科
  • 病理学各論実習
    開講年度 : 2018年
    課程区分 : 学士課程
    開講学部 : 獣医学部
    キーワード : 疾患,病理学,診断学
  • 先端獣医科学特論A 国際獣医科学特論:臨床獣医学
    開講年度 : 2018年
    課程区分 : 博士後期課程
    開講学部 : 獣医学研究科
  • アカデミックイングリッシュ
    開講年度 : 2018年
    課程区分 : 博士後期課程
    開講学部 : 獣医学院
  • 獣医科学基礎科目 臨床疾病学特論
    開講年度 : 2018年
    課程区分 : 博士後期課程
    開講学部 : 獣医学院
  • 先端獣医科学科目 獣医病理学特論
    開講年度 : 2018年
    課程区分 : 博士後期課程
    開講学部 : 獣医学院
  • 総合専門臨床特論
    開講年度 : 2018年
    課程区分 : 博士後期課程
    開講学部 : 獣医学院
  • 獣医病理診断学演習
    開講年度 : 2018年
    課程区分 : 学士課程
    開講学部 : 獣医学部
  • アドバンスト演習
    開講年度 : 2018年
    課程区分 : 学士課程
    開講学部 : 獣医学部


Copyright © MEDIA FUSION Co.,Ltd. All rights reserved.