基本情報

所属

• 医学研究院　医学教育・国際交流推進センター

職名

• 准教授

学位

• 医学博士（北海道大学）

科研費研究者番号

• 40713607

J-Global ID

• 201601003557622791

研究キーワード

• Biomarkers   Public health   Medical Education   Epidemiology   Respiratory Medicine   Genetic Medicine   Childhood asthma   COPD   Allergy   Adulthood Asthma   

研究分野

• ライフサイエンス / 呼吸器内科学 / Asthma, and allergies in children and adults

担当教育組織

•  学士課程　医学部（医学科）
•  修士課程　医学院
•  博士課程　医学院

職歴

• 2023年04月 - 現在 北海道大学 大学院医学研究院 准教授
• 2016年03月 - 現在 Graduate School of Medicine, Division of Respiratory Medicine

学歴

• 2013年04月 - 2016年03月   Hokkaido University Center for Environmental and Health Sicences
• 2008年04月 - 2013年03月   Hokkaido University, Graduate School of Medicine, Institute For Genetic Medicine   Cancer Stem Cell Biology
• 1997年02月 - 2005年09月   Tehran University, School of Medicine

所属学協会

• The Association for Medical Education in Europe (AMEE)   Japanese Society of Allergology (JSA)   Japanese Respiratory Society (JRS)   European Respiratory Society (ERS)   Japan Society for Medical English Education (JASMEE)   Japan Society for Medical Education (JSME)   International Society for Environmental Epidemiology   Japanese Cancer Association   

研究活動情報

論文

• Association of serum CC16 levels with eosinophilic inflammation and respiratory dysfunction in severe asthma.

  Houman Goudarzi, Hirokazu Kimura, Hiroki Kimura, Hironi Makita, Michiko Takimoto-Sato, Yuki Abe, Akira Oguma, Munehiro Matsumoto, Nozomu Takei, Machiko Matsumoto-Sasaki, Kaoruko Shimizu, Masaru Suzuki, Noriharu Shijubo, Shau-Ku Huang, Nobuyuki Hizawa, Masaharu Nishimura, Satoshi Konno

  Respiratory medicine 206 107089 - 107089 2023年01月 

  BACKGROUND: There are knowledge gaps in the potential role of Club cell 16-kDa secretory protein (CC16) in severe asthma phenotypes and type 2 inflammation, as well as the longitudinal effect of CC16 on pulmonary function tests and exacerbation risk in epidemiological studies. OBJECTIVE AND METHODS: To assess whether serum CC16 is associated with eosinophilic inflammation in patients with severe asthma. We also examined the effect of this protein on the annual decline in forced expiratory volume in the first second (FEV1) and the risk of exacerbation using a longitudinal approach. We recruited 127 patients with severe asthma from 30 hospitals/pulmonary clinics in Hokkaido, Japan. The least square means and standard error were calculated for T-helper 2 (Th2) biomarkers and pulmonary function test across CC16 tertiles at baseline. We did the same for asthma exacerbation and annual decline in FEV1 with 3 and 5 years' follow-up, respectively. RESULTS: We found that serum CC16 was inversely associated with sputum eosinophils and blood periostin in a dose-response manner. Baseline CC16 and FEV1/forced vital capacity ratio were positively associated in adjusted models (p for trend = 0.008). Patients with the lowest tertile of serum CC16 levels at baseline had a -14.3 mL decline in FEV1 than those with the highest tertile over 5 years of follow-up (p for trend = 0.031, fully adjusted model). We did not find any association of CC16 with exacerbation risk. CONCLUSION: Patients with severe asthma with lower circulatory CC16 had enhanced eosinophilic inflammation with rapid FEV1 decline over time.
• Blood eosinophil count variability in chronic obstructive pulmonary disease and severe asthma.

  Yuki Abe, Masaru Suzuki, Hirokazu Kimura, Kaoruko Shimizu, Nozomu Takei, Akira Oguma, Machiko Matsumoto-Sasaki, Houman Goudarzi, Hironi Makita, Masaharu Nishimura, Satoshi Konno

  Allergology international : official journal of the Japanese Society of Allergology 2022年12月29日 

  BACKGROUND: Blood eosinophils are essential biomarkers that vary substantially over time in patients with COPD and asthma. However, no study has identified the changes and effects in the changes of the blood eosinophil counts over time in both diseases. This study aimed to demonstrate blood eosinophil variability in patients with COPD and severe asthma based on these backgrounds. METHODS: A total of 172 patients with COPD from the Hokkaido COPD cohort study and 96 patients with severe asthma from the Hokkaido Severe Asthma Cohort Study, whose blood eosinophil counts were measured annually over a 3-year period, were analyzed. The factors contributing to consistently high or low blood eosinophil counts were examined in each cohort. The stability of the eosinophil classification (<150, 150-299, ≥300 cells/μL) was compared based on the number of asthma-like features in patients with COPD and the smoking status in patients with severe asthma. RESULTS: Among all the patients, the most stable range of baseline blood eosinophil counts differed between the two diseases, with <150 cells/μL in COPD and ≥300 cells/μL in severe asthma. In COPD, the number of asthma-like features (bronchodilator reversibility, blood eosinophilia, and atopy) affects the blood eosinophil count variation patterns. In severe asthma, smoking status did not affect the blood eosinophil count variation patterns. CONCLUSIONS: We identified variations in the blood eosinophil counts and their contributing factors in patients with COPD and severe asthma.
• Differential role of mucus plugs in asthma: Effects of smoking and association with airway inflammation.

  Akira Oguma, Kaoruko Shimizu, Hirokazu Kimura, Naoya Tanabe, Susumu Sato, Isao Yokota, Michiko Takimoto-Sato, Machiko Matsumoto-Sasaki, Yuki Abe, Nozomu Takei, Houman Goudarzi, Masaru Suzuki, Hironi Makita, Toyohiro Hirai, Masaharu Nishimura, Satoshi Konno

  Allergology international : official journal of the Japanese Society of Allergology 72 2 262 - 270 2022年11月16日 

  BACKGROUND: The physiological importance of mucus plugs in computed tomography (CT) imaging is being increasingly recognized. However, whether airway inflammation and smoking affect the association between mucus plugs and clinical-physiological outcomes in asthma remains to be elucidated. The objective of this study is to examine how airway inflammation and/or smoking affect the correlation of CT-based mucus plug scores with exacerbation frequency and airflow limitation indices in asthma. METHODS: A total of 168 patients with asthma who underwent chest CT and sputum evaluation were enrolled and classified in eosinophilic asthma (EA; n = 103) and non-eosinophilic asthma (NEA; n = 65) groups based on sputum eosinophil percentage (cut-off: 3%). The mucus plug score was defined as the number of lung segments with mucus plugs seen on CT. RESULTS: More mucus plugs were detected on CT scans in the EA group than in the NEA group, regardless of smoking status. Mucus plug score and exacerbation frequency during one year after enrollment were significantly associated in the EA group but not in the NEA group after adjusting for demographics, blood eosinophil count, and fractional exhaled nitric oxide. Mucus plug score was associated with percentage of predicted forced expiratory volume in 1 s in non-smoking individuals in the EA and NEA group and in smoking individuals in the EA group but not in the NEA group after adjusting for demographics. CONCLUSIONS: The association of mucus plug score with exacerbation frequency and reduced lung function may vary due to airway inflammatory profile and smoking status in asthma.
• Potential determinants of T helper 2 markers and their distribution in school-aged children

  Houman Goudarzi, Atsuko Ikeda-Araki, Yu Ait Bamai, Sachiko Ito, Tasuku Inao, Isao Yokota, Chihiro Miyashita, Reiko Kishi, Satoshi Konno

  Allergology International 72 1 100 - 106 2022年08月 [査読有り]
   

  BACKGROUND: There is growing data on T helper 2 (Th2) biomarker determinants in adult populations. However, the determinants and typical range of these biomarkers have not been well studied in general populations of children. Therefore, we assessed the determinants and typical range of three Th2 biomarkers, including blood eosinophils, FeNO, and serum total IgE in 9-11-year-old children in a prospective birth cohort. METHODS: We examined the pre- and postnatal factors associated with Th2 biomarkers using multivariable logistic regression analysis (n = 428) and extended the results to the original cohort (n = 17,009) using inverse probability weighting. We also measured typical Th2 biomarker distribution in all examined children and healthy participants without allergic diseases (n = 180). RESULTS: At age 9-11, wheeze (odds ratio (OR) 7.63), rhinitis (OR 3.14), and eczema (OR 2.46) were significantly associated with increased blood eosinophils. All three allergic conditions were associated with FeNO and total serum IgE, but the ORs were smaller than those for blood eosinophils. Secondhand smoking was inversely associated with the blood eosinophils (OR, 0.38). Similar results were found in the original cohort. Male sex and prenatal factors (maternal smoking and parental history of allergies) were not independent predictors of high Th2 levels. CONCLUSIONS: In addition to wheezing and rhinitis, eczema and secondhand smoke exposure are independent factors for Th2 biomarker interpretation in children. Furthermore, the typical values and cutoff values of blood eosinophils in adults may not be applicable to children.
• Effects of obesity on CC16 and their potential role in overweight/obese asthma.

  Houman Goudarzi, Hirokazu Kimura, Hiroki Kimura, Hironi Makita, Munehiro Matsumoto, Nozomu Takei, Kaoruko Shimizu, Masaru Suzuki, Taku Watanabe, Eiki Kikuchi, Hiroshi Ohira, Ichizo Tsujino, Jun Sakakibara-Konishi, Naofumi Shinagawa, Noriharu Shijubo, Hirokazu Sato, Katsunori Shigehara, Kichizo Kaga, Yasuhiro Hida, Soichi Murakami, Yuma Ebihara, Akinobu Nakamura, Hideaki Miyoshi, Satoshi Hirano, Nobuyuki Hizawa, Tatsuya Atsumi, Shau-Ku Huang, Yoichi M Ito, Masaharu Nishimura, Satoshi Konno

  Respiratory research 23 1 174 - 174 2022年06月29日 [査読有り]
   

  INTRODUCTION: Club cell secretory protein-16 (CC16) is a major anti-inflammatory protein expressed in the airway; however, the potential role of CC16 on overweight/obese asthma has not been assessed. In this study, we examined whether obesity reduces airway/circulatory CC16 levels using experimental and epidemiological studies. Then, we explored the mediatory role of CC16 in the relationship of overweight/obesity with clinical asthma measures. METHODS: Circulating CC16 levels were assessed by ELISA in three independent human populations, including two groups of healthy and general populations and asthma patients. The percentage of cells expressing club markers in obese vs. non-obese mice and human airways was determined by immunohistochemistry. A causal mediation analysis was conducted to determine whether circulatory CC16 acted as a mediator between overweight/obesity and clinical asthma measures. RESULTS: BMI was significantly and monotonously associated with reduced circulating CC16 levels in all populations. The percentage of CC16-expressing cells was reduced in the small airways of both mice and humans with obesity. Finally, mediation analysis revealed significant contributions of circulatory CC16 in the association between BMI and clinical asthma measures; 21.8% of its total effect in BMI's association with airway hyperresponsiveness of healthy subjects (p = 0.09), 26.4% with asthma severity (p = 0.030), and 23% with the required dose of inhaled corticosteroid (p = 0.042). In logistic regression analysis, 1-SD decrease in serum CC16 levels of asthma patients was associated with 87% increased odds for high dose ICS requirement (p < 0.001). CONCLUSIONS: We demonstrate that airway/circulating CC16, which is inversely associated with BMI, may mediate development and severity in overweight/obese asthma.
• Measuring the availability of human resources for health and its relationship to universal health coverage for 204 countries and territories from 1990 to 2019: a systematic analysis for the Global Burden of Disease Study 2019

  Annie Haakenstad, Caleb Mackay Salpeter Irvine, Megan Knight, Corinne Bintz, Aleksandr Y Aravkin, Peng Zheng, Vin Gupta, Michael R M Abrigo, Abdelrahman I Abushouk, Oladimeji M Adebayo, Gina Agarwal, Fares Alahdab, Ziyad Al-Aly, Khurshid Alam, Turki M Alanzi, Jacqueline Elizabeth Alcalde-Rabanal, Vahid Alipour, Nelson Alvis-Guzman, Arianna Maever L Amit, Catalina Liliana Andrei, Tudorel Andrei, Carl Abelardo T Antonio, Jalal Arabloo, Olatunde Aremu, Martin Amogre Ayanore, Maciej Banach, Till Winfried Bärnighausen, Celine M Barthelemy, Mohsen Bayati, Habib Benzian, Adam E Berman, Kelly Bienhoff, Ali Bijani, Boris Bikbov, Antonio Biondi, Archith Boloor, Reinhard Busse, Zahid A Butt, Luis Alberto Cámera, Ismael R Campos-Nonato, Rosario Cárdenas, Felix Carvalho, Collins Chansa, Soosanna Kumary Chattu, Vijay Kumar Chattu, Dinh-Toi Chu, Xiaochen Dai, Lalit Dandona, Rakhi Dandona, William James Dangel, Ahmad Daryani, Jan-Walter De Neve, Meghnath Dhimal, Isaac Oluwafemi Dipeolu, Shirin Djalalinia, Hoa Thi Do, Chirag P Doshi, Leila Doshmangir, Elham Ehsani-Chimeh, Maha El Tantawi, Eduarda Fernandes, Florian Fischer, Nataliya A Foigt, Artem Alekseevich Fomenkov, Masoud Foroutan, Takeshi Fukumoto, Nancy Fullman, Mohamed M Gad, Keyghobad Ghadiri, Mansour Ghafourifard, Ahmad Ghashghaee, Thomas Glucksman, Houman Goudarzi, Rajat Das Gupta, Randah R Hamadeh, Samer Hamidi, Josep Maria Haro, Edris Hasanpoor, Simon I Hay, Mohamed I Hegazy, Behzad Heibati, Nathaniel J Henry, Michael K Hole, Naznin Hossain, Mowafa Househ, Olayinka Stephen Ilesanmi, Mohammad-Hasan Imani-Nasab, Seyed Sina Naghibi Irvani, Sheikh Mohammed Shariful Islam, Mohammad Ali Jahani, Ankur Joshi, Rohollah Kalhor, Gbenga A Kayode, Nauman Khalid, Khaled Khatab, Adnan Kisa, Sonali Kochhar, Kewal Krishan, Barthelemy Kuate Defo, Dharmesh Kumar Lal, Faris Hasan Lami, Anders O Larsson, Janet L Leasher, Kate E LeGrand, Lee-Ling Lim, Narayan B Mahotra, Azeem Majeed, Afshin Maleki, Narayana Manjunatha, Benjamin Ballard Massenburg, Tomislav Mestrovic, GK Mini, Andreea Mirica, Erkin M Mirrakhimov, Yousef Mohammad, Shafiu Mohammed, Ali H Mokdad, Shane Douglas Morrison, Mohsen Naghavi, Duduzile Edith Ndwandwe, Ionut Negoi, Ruxandra Irina Negoi, Josephine W Ngunjiri, Cuong Tat Nguyen, Yeshambel T Nigatu, Obinna E Onwujekwe, Doris V Ortega-Altamirano, Nikita Otstavnov, Stanislav S Otstavnov, Mayowa O Owolabi, Abhijit P Pakhare, Veincent Christian Filipino Pepito, Norberto Perico, Hai Quang Pham, David M Pigott, Khem Narayan Pokhrel, Mohammad Rabiee, Navid Rabiee, Vafa Rahimi-Movaghar, David Laith Rawaf, Salman Rawaf, Lal Rawal, Giuseppe Remuzzi, Andre M N Renzaho, Serge Resnikoff, Nima Rezaei, Aziz Rezapour, Jennifer Rickard, Leonardo Roever, Maitreyi Sahu, Abdallah M Samy, Juan Sanabria, Milena M Santric-Milicevic, Sivan Yegnanarayana Iyer Saraswathy, Soraya Seedat, Subramanian Senthilkumaran, Edson Serván-Mori, Masood Ali Shaikh, Aziz Sheikh, Diego Augusto Santos Silva, Caroline Stein, Dan J Stein, Mariya Vladimirovna Titova, Stephanie M Topp, Marcos Roberto Tovani-Palone, Saif Ullah, Bhaskaran Unnikrishnan, Marco Vacante, Pascual R Valdez, Tommi Juhani Vasankari, Narayanaswamy Venketasubramanian, Vasily Vlassov, Theo Vos, Jamal Akeem Yearwood, Naohiro Yonemoto, Mustafa Z Younis, Chuanhua Yu, Siddhesh Zadey, Sojib Bin Zaman, Taddese Alemu Zerfu, Zhi-Jiang Zhang, Arash Ziapour, Sanjay Zodpey, Stephen S Lim, Christopher J L Murray, Rafael Lozano

  The Lancet 399 10341 2129 - 2154 2022年06月 [査読有り]
  
• Further evidence for association of YKL-40 with severe asthma airway remodeling

  Hirokazu Kimura, Kaoruko Shimizu, Naoya Tanabe, Hironi Makita, Natsuko Taniguchi, Hiroki Kimura, Masaru Suzuki, Yuki Abe, Machiko Matsumoto-Sasaki, Akira Oguma, Michiko Takimoto-Sato, Nozomu Takei, Munehiro Matsumoto, Houman Goudarzi, Susumu Sato, Junya Ono, Kenji Izuhara, Toyohiro Hirai, Masaharu Nishimura, Satoshi Konno

  Annals of Allergy, Asthma & Immunology 2022年03月 [査読有り]
  
• The global burden of adolescent and young adult cancer in 2019: a systematic analysis for the Global Burden of Disease Study 2019

  Elysia M Alvarez, Lisa M Force, Rixing Xu, Kelly Compton, Dan Lu, Hannah Jacqueline Henrikson, Jonathan M Kocarnik, James D Harvey, Alyssa Pennini, Frances E Dean, Weijia Fu, Martina T Vargas, Theresa H M Keegan, Hany Ariffin, Ronald D Barr, Yana Arturovna Erdomaeva, D Sanjeeva Gunasekera, Yetunde O John-Akinola, Tyler G Ketterl, Tezer Kutluk, Marcio Henrique Malogolowkin, Prashant Mathur, Venkatraman Radhakrishnan, Lynn Ann Gloeckler Ries, Carlos Rodriguez-Galindo, Garik Barisovich Sagoyan, Iyad Sultan, Behzad Abbasi, Mohsen Abbasi-Kangevari, Zeinab Abbasi-Kangevari, Hedayat Abbastabar, Michael Abdelmasseh, Sherief Abd-Elsalam, Amir Abdoli, Haimanot Abebe, Aidin Abedi, Hassan Abidi, Hassan Abolhassani, Hiwa Abubaker Ali, Eman Abu-Gharbieh, Basavaprabhu Achappa, Juan Manuel Acuna, Isaac Akinkunmi Adedeji, Oyelola A Adegboye, Qorinah Estiningtyas Sakilah Adnani, Shailesh M Advani, Muhammad Sohail Afzal, Mohamad Aghaie Meybodi, Bahman Ahadinezhad, Bright Opoku Ahinkorah, Sajjad Ahmad, Sepideh Ahmadi, Muktar Beshir Ahmed, Tarik Ahmed Rashid, Yusra Ahmed Salih, Wajeeha Aiman, Gizachew Taddesse Akalu, Hanadi Al Hamad, Fares Alahdab, Abdulhadi A AlAmodi, Fahad Mashhour Alanezi, Turki M Alanzi, Adugnaw Zeleke Alem, Dejene Tsegaye Alem, Yosef Alemayehu, Fadwa Naji Alhalaiqa, Robert Kaba Alhassan, Saqib Ali, Gianfranco Alicandro, Vahid Alipour, Syed Mohamed Aljunid, Motasem Alkhayyat, Sunitha Alluri, Nihad A Almasri, Sadeq Ali Al-Maweri, Sami Almustanyir, Rajaa M Al-Raddadi, Nelson Alvis-Guzman, Edward Kwabena Ameyaw, Saeed Amini, Hubert Amu, Robert Ancuceanu, Catalina Liliana Andrei, Tudorel Andrei, Fereshteh Ansari, Alireza Ansari-Moghaddam, Davood Anvari, Anayochukwu Edward Anyasodor, Jalal Arabloo, Morteza Arab-Zozani, Ayele Mamo Argaw, Muhammad Arshad, Judie Arulappan, Armin Aryannejad, Zatollah Asemi, Mohammad Asghari Jafarabadi, Mohammad Reza Atashzar, Prince Atorkey, Alok Atreya, Sameh Attia, Avinash Aujayeb, Marcel Ausloos, Leticia Avila-Burgos, Atalel Fentahun Awedew, Beatriz Paulina Ayala Quintanilla, Alemu Degu Ayele, Solomon Shitu Ayen, Mohammed A Azab, Sina Azadnajafabad, Hiva Azami, Mohammadreza Azangou-Khyavy, Amirhossein Azari Jafari, Ghasem Azarian, Ahmed Y Azzam, Saeed Bahadory, Jianjun Bai, Atif Amin Baig, Jennifer L Baker, Maciej Banach, Till Winfried Bärnighausen, Francesco Barone-Adesi, Fabio Barra, Amadou Barrow, Huda Basaleem, Abdul-Monim Mohammad Batiha, Masoud Behzadifar, Niguss Cherie Bekele, Rebuma Belete, Uzma Iqbal Belgaumi, Arielle Wilder Bell, Alemshet Yirga Berhie, Devidas S Bhagat, Akshaya Srikanth Bhagavathula, Nikha Bhardwaj, Pankaj Bhardwaj, Sonu Bhaskar, Krittika Bhattacharyya, Vijayalakshmi S Bhojaraja, Sadia Bibi, Ali Bijani, Antonio Biondi, Setognal Birara, Tone Bjørge, Obasanjo Afolabi Bolarinwa, Srinivasa Rao Bolla, Archith Boloor, Dejana Braithwaite, Hermann Brenner, Norma B Bulamu, Katrin Burkart, Maria Teresa Bustamante-Teixeira, Nadeem Shafique Butt, Zahid A Butt, Florentino Luciano Caetano dos Santos, Chao Cao, Yin Cao, Giulia Carreras, Ferrán Catalá-López, Francieli Cembranel, Ester Cerin, Raja Chandra Chakinala, Promit Ananyo Chakraborty, Vijay Kumar Chattu, Pankaj Chaturvedi, Akhilanand Chaurasia, Prachi P Chavan, Odgerel Chimed-Ochir, Jee-Young Jasmine Choi, Devasahayam J Christopher, Dinh-Toi Chu, Michael T Chung, Joao Conde, Vera Marisa Costa, Omar B Da'ar, Omid Dadras, Saad M A Dahlawi, Xiaochen Dai, Giovanni Damiani, Emanuele D'Amico, Lalit Dandona, Rakhi Dandona, Parnaz Daneshpajouhnejad, Amira Hamed Darwish, Ahmad Daryani, Fernando Pio De la Hoz, Sisay Abebe Debela, Takele Gezahegn G Demie, Getu Debalkie Demissie, Zeleke Geto Demissie, Edgar Denova-Gutiérrez, Meseret Derbew Molla, Rupak Desai, Abebaw Alemayehu Desta, Deepak Dhamnetiya, Samath Dhamminda Dharmaratne, Mandira Lamichhane Dhimal, Meghnath Dhimal, Mostafa Dianatinasab, Mojtaba Didehdar, Mengistie Diress, Shirin Djalalinia, Huyen Phuc Do, Saeid Doaei, Fariba Dorostkar, Wendel Mombaque dos Santos, Thomas M Drake, Michael Ekholuenetale, Iman El Sayed, Maysaa El Sayed Zaki, Maha El Tantawi, Hassan El-Abid, Mostafa Ahmed Elbahnasawy, Iffat Elbarazi, Hala Rashad Elhabashy, Muhammed Elhadi, Shaimaa I El-Jaafary, Daniel Berhanie Enyew, Ryenchindorj Erkhembayar, Babak Eshrati, Sharareh Eskandarieh, Mohammed Faisaluddin, Jawad Fares, Umar Farooque, Abidemi Omolara Fasanmi, Wafa Fatima, José Miguel P Ferreira de Oliveira, Simone Ferrero, Lorenzo Ferro Desideri, Getahun Fetensa, Irina Filip, Florian Fischer, James L Fisher, Masoud Foroutan, Takeshi Fukumoto, Peter Andras Gaal, Mohamed M Gad, Piyada Gaewkhiew, Silvano Gallus, Tushar Garg, Teferi Gebru Gebremeskel, Belete Negese Belete Gemeda, Tamiru Getachew, Mansour Ghafourifard, Seyyed-Hadi Ghamari, Ahmad Ghashghaee, Fariba Ghassemi, Nermin Ghith, Ali Gholami, Jamshid Gholizadeh Navashenaq, Syed Amir Gilani, Themba G Ginindza, Abraham Tamirat Gizaw, James C Glasbey, Amit Goel, Mahaveer Golechha, Pouya Goleij, Davide Golinelli, Sameer Vali Gopalani, Giuseppe Gorini, Houman Goudarzi, Bárbara Niegia Garcia Goulart, Ayman Grada, Mohammed Ibrahim Mohialdeen Gubari, Maximiliano Ribeiro Guerra, Avirup Guha, Bhawna Gupta, Sapna Gupta, Veer Bala Gupta, Vivek Kumar Gupta, Rasool Haddadi, Nima Hafezi-Nejad, Alemayehu Hailu, Arvin Haj-Mirzaian, Rabih Halwani, Randah R Hamadeh, Mitiku Teshome Hambisa, Sajid Hameed, Samer Hamidi, Shafiul Haque, Sanam Hariri, Josep Maria Haro, Ahmed I Hasaballah, S M Mahmudul Hasan, Seyedeh Melika Hashemi, Treska S Hassan, Soheil Hassanipour, Simon I Hay, Khezar Hayat, Sultan H Hebo, Golnaz Heidari, Mohammad Heidari, Brenda Yuliana Herrera-Serna, Claudiu Herteliu, Demisu Zenbaba Heyi, Kamal Hezam, Michael K Hole, Ramesh Holla, Nobuyuki Horita, Md Mahbub Hossain, Mohammad Bellal Hossain, Mohammad-Salar Hosseini, Mostafa Hosseini, Ali Hosseinzadeh, Mehdi Hosseinzadeh, Mihaela Hostiuc, Sorin Hostiuc, Mowafa Househ, Mohamed Hsairi, Junjie Huang, Nawfal R Hussein, Bing-Fang Hwang, Segun Emmanuel Ibitoye, Olayinka Stephen Ilesanmi, Irena M Ilic, Milena D Ilic, Kaire Innos, Lalu Muhammad Irham, Rakibul M Islam, Sheikh Mohammed Shariful Islam, Nahlah Elkudssiah Ismail, Gaetano Isola, Masao Iwagami, Louis Jacob, Farhad Jadidi-Niaragh, Vardhmaan Jain, Mihajlo Jakovljevic, Roksana Janghorban, Amirreza Javadi Mamaghani, Shubha Jayaram, Ranil Jayawardena, Seyed Behzad Jazayeri, Rime Jebai, Ravi Prakash Jha, Tamas Joo, Nitin Joseph, Farahnaz Joukar, Mikk Jürisson, Billingsley Kaambwa, Ali Kabir, Leila R Kalankesh, Feroze Kaliyadan, Zul Kamal, Ashwin Kamath, Himal Kandel, Sitanshu Sekhar Kar, Ibraheem M Karaye, Amirali Karimi, Bekalu Getnet Kassa, Joonas H Kauppila, Phillip M Kemp Bohan, Andre Pascal Kengne, Amene Abebe Kerbo, Mohammad Keykhaei, Yousef Saleh Khader, Himanshu Khajuria, Nastaran Khalili, Neda Khalili, Ejaz Ahmad Khan, Gulfaraz Khan, Maseer Khan, Md Nuruzzaman Khan, Moien AB Khan, Javad Khanali, Maryam Khayamzadeh, Omid Khosravizadeh, Jagdish Khubchandani, Roba Khundkar, Min Seo Kim, Yun Jin Kim, Adnan Kisa, Sezer Kisa, Katarzyna Kissimova-Skarbek, Ali-Asghar Kolahi, Jacek A Kopec, Rajasekaran Koteeswaran, Sindhura Lakshmi Koulmane Laxminarayana, Ai Koyanagi, Nuworza Kugbey, G Anil Kumar, Nithin Kumar, Alexander Kwarteng, Carlo La Vecchia, Qing Lan, Iván Landires, Savita Lasrado, Paolo Lauriola, Caterina Ledda, Sang-woong Lee, Wei-Chen Lee, Yeong Yeh Lee, Yo Han Lee, James Leigh, Elvynna Leong, Bingyu Li, Jiarui Li, Ming-Chieh Li, Stephen S Lim, Xuefeng Liu, Stany W Lobo, Joana A Loureiro, Alessandra Lugo, Raimundas Lunevicius, Hassan Magdy Abd El Razek, Muhammed Magdy Abd El Razek, Morteza Mahmoudi, Azeem Majeed, Alaa Makki, Shilpa Male, Mohammad-Reza Malekpour, Reza Malekzadeh, Ahmad Azam Malik, Mohammed A Mamun, Navid Manafi, Fariborz Mansour-Ghanaei, Borhan Mansouri, Mohammad Ali Mansournia, Santi Martini, Seyedeh Zahra Masoumi, Clara N Matei, Manu Raj Mathur, Colm McAlinden, Ravi Mehrotra, Walter Mendoza, Ritesh G Menezes, Alexios-Fotios A Mentis, Tuomo J Meretoja, Amanual Getnet Mersha, Mohamed Kamal Mesregah, Tomislav Mestrovic, Junmei Miao Jonasson, Bartosz Miazgowski, Irmina Maria Michalek, Ted R Miller, Alemu Basazin Mingude, Seyyedmohammadsadeq Mirmoeeni, Hamed Mirzaei, Sanjeev Misra, Prasanna Mithra, Karzan Abdulmuhsin Mohammad, Mokhtar Mohammadi, Seyyede Momeneh Mohammadi, Abdollah Mohammadian-Hafshejani, Reza Mohammadpourhodki, Arif Mohammed, Shafiu Mohammed, Teroj Abdulrahman Mohammed, Nagabhishek Moka, Ali H Mokdad, Mariam Molokhia, Sara Momtazmanesh, Lorenzo Monasta, Mohammad Ali Moni, Ghobad Moradi, Yousef Moradi, Maliheh Moradzadeh, Rahmatollah Moradzadeh, Paula Moraga, Shane Douglas Morrison, Ebrahim Mostafavi, Amin Mousavi Khaneghah, Christine Mpundu-Kaambwa, Sumaira Mubarik, Lillian Mwanri, Ashraf F Nabhan, Shankar Prasad Nagaraju, Chie Nagata, Mohsen Naghavi, Mukhammad David Naimzada, Luigi Naldi, Vinay Nangia, Atta Abbas Naqvi, Sreenivas Narasimha Swamy, Aparna Ichalangod Narayana, Biswa Prakash Nayak, Vinod C Nayak, Javad Nazari, Sabina Onyinye Nduaguba, Ionut Negoi, Serban Mircea Negru, Seyed Aria Nejadghaderi, Samata Nepal, Sandhya Neupane Kandel, Haruna Asura Nggada, Cuong Tat Nguyen, Chukwudi A Nnaji, Hamed Nosrati, Hasti Nouraei, Ali Nowroozi, Virginia Nuñez-Samudio, Vincent Ebuka Nwatah, Chimezie Igwegbe Nzoputam, Bogdan Oancea, Oluwakemi Ololade Odukoya, Ayodipupo Sikiru Oguntade, In-Hwan Oh, Andrew T Olagunju, Tinuke O Olagunju, Babayemi Oluwaseun Olakunde, Mojisola Morenike Oluwasanu, Emad Omar, Ahmed Omar Bali, Sokking Ong, Obinna E Onwujekwe, Doris V Ortega-Altamirano, Nikita Otstavnov, Stanislav S Otstavnov, Bilcha Oumer, Mayowa O Owolabi, Mahesh P A, Alicia Padron-Monedero, Jagadish Rao Padubidri, Keyvan Pakshir, Adrian Pana, Anamika Pandey, Shahina Pardhan, Fatemeh Pashazadeh Kan, Maja Pasovic, Jenil R Patel, Siddhartha Pati, Sanjay M Pattanshetty, Uttam Paudel, Renato B Pereira, Mario F P Peres, Arokiasamy Perianayagam, Maarten J Postma, Hadi Pourjafar, Akram Pourshams, Akila Prashant, Thejodhar Pulakunta, Mirza Muhammad Fahd Fahd Qadir, Mohammad Rabiee, Navid Rabiee, Amir Radfar, Raghu Anekal Radhakrishnan, Ata Rafiee, Alireza Rafiei, Sima Rafiei, Fakher Rahim, Shadi Rahimzadeh, Mosiur Rahman, Muhammad Aziz Rahman, Amir Masoud Rahmani, Aashish Rajesh, Vajiheh Ramezani-Doroh, Kamal Ranabhat, Priyanga Ranasinghe, Chythra R Rao, Sowmya J Rao, Sina Rashedi, Mahsa Rashidi, Mohammad-Mahdi Rashidi, Goura Kishor Rath, David Laith Rawaf, Salman Rawaf, Lal Rawal, Reza Rawassizadeh, Mohammad Sadegh Razeghinia, Misganu Teshoma Regasa, Andre M N Renzaho, Maryam Rezaei, Negar Rezaei, Nima Rezaei, Mohsen Rezaeian, Aziz Rezapour, Sahba Rezazadeh-Khadem, Abanoub Riad, Ligia Estefania Rios Lopez, Jefferson Antonio Buendia Rodriguez, Luca Ronfani, Gholamreza Roshandel, Godfrey M Rwegerera, Maha Mohamed Saber-Ayad, Siamak Sabour, Basema Saddik, Erfan Sadeghi, Saeid Sadeghian, Umar Saeed, Amirhossein Sahebkar, KM Saif-Ur-Rahman, S Mohammad Sajadi, Sarvenaz Salahi, Sana Salehi, Marwa Rashad Salem, Hamideh Salimzadeh, Abdallah M Samy, Juan Sanabria, Francesco Sanmarchi, Arash Sarveazad, Brijesh Sathian, Monika Sawhney, Susan M Sawyer, Mete Saylan, Ione Jayce Ceola Schneider, Abdul-Aziz Seidu, Mario Šekerija, Endalew Gemechu Sendo, Sadaf G Sepanlou, Allen Seylani, Kenbon Seyoum, Feng Sha, Omid Shafaat, Masood Ali Shaikh, Erfan Shamsoddin, Mohammed Shannawaz, Rajesh Sharma, Sara Sheikhbahaei, Adithi Shetty, B Suresh Kumar Shetty, Pavanchand H Shetty, Jae Il Shin, Reza Shirkoohi, K M Shivakumar, Parnian Shobeiri, Soraya Siabani, Migbar Mekonnen Sibhat, Sudeep K Siddappa Malleshappa, Negussie Boti Sidemo, Diego Augusto Santos Silva, Guilherme Silva Julian, Achintya Dinesh Singh, Jasvinder A Singh, Jitendra Kumar Singh, Surjit Singh, Abiy H Sinke, Yitagesu Sintayehu, Valentin Yurievich Skryabin, Anna Aleksandrovna Skryabina, Lee Smith, Ahmad Sofi-Mahmudi, Mohammad Sadegh Soltani-Zangbar, Suhang Song, Emma Elizabeth Spurlock, Paschalis Steiropoulos, Kurt Straif, Ranjeeta Subedi, Mu'awiyyah Babale Sufiyan, Rizwan Suliankatchi Abdulkader, Saima Sultana, Viktória Szerencsés, Miklós Szócska, Seidamir Pasha Tabaeian, Rafael Tabarés-Seisdedos, Mohammadreza Tabary, Takahiro Tabuchi, Hooman Tadbiri, Majid Taheri, Amir Taherkhani, Ken Takahashi, Mircea Tampa, Ker-Kan Tan, Vivian Y Tat, Ahmad Tavakoli, Abdelghani Tbakhi, Arash Tehrani-Banihashemi, Mohamad-Hani Temsah, Fisaha Haile Tesfay, Bekele Tesfaye, Jarnail Singh Thakur, Rekha Thapar, Aravind Thavamani, Arulmani Thiyagarajan, Nihal Thomas, Ruoyan Tobe-Gai, Munkhsaikhan Togtmol, Seyed Abolfazl Tohidast, Hamid Reza Tohidinik, Musliu Adetola Tolani, Daniel Nigusse Tollosa, Mathilde Touvier, Marcos Roberto Tovani-Palone, Eugenio Traini, Bach Xuan Tran, Mai Thi Ngoc Tran, Jaya Prasad Tripathy, Biruk Shalmeno Tusa, Gebresilasea Gendisha Ukke, Irfan Ullah, Saif Ullah, Krishna Kishore Umapathi, Bhaskaran Unnikrishnan, Era Upadhyay, Tolassa Wakayo Ushula, Marco Vacante, Sahel Valadan Tahbaz, Shoban Babu Varthya, Massimiliano Veroux, Paul J Villeneuve, Francesco S Violante, Vasily Vlassov, Giang Thu Vu, Yasir Waheed, Ning Wang, Paul Ward, Adisu Birhanu Weldesenbet, Yi Feng Wen, Ronny Westerman, Andrea Sylvia Winkler, Befikadu Legesse Wubishet, Suowen Xu, Seyed Hossein Yahyazadeh Jabbari, Lin Yang, Sanni Yaya, Vahid Yazdi-Feyzabadi, Taklo Simeneh Yazie, Sisay Shewasinad Yehualashet, Alex Yeshaneh, Yigizie Yeshaw, Birhanu Wubale Yirdaw, Naohiro Yonemoto, Mustafa Z Younis, Zabihollah Yousefi, Chuanhua Yu, Ismaeel Yunusa, Vesna Zadnik, Mazyar Zahir, Telma Zahirian Moghadam, Mohammad Zamani, Maryam Zamanian, Hamed Zandian, Fariba Zare, Mikhail Sergeevich Zastrozhin, Anasthasia Zastrozhina, Jianrong Zhang, Zhi-Jiang Zhang, Arash Ziapour, Mohammad Zoladl, Christopher J L Murray, Christina Fitzmaurice, Archie Bleyer, Nickhill Bhakta

  The Lancet Oncology 23 1 27 - 52 2022年01月
• Relationships between maternal perfluoroalkyl substance levels, polymorphisms of receptor genes, and adverse birth outcomes in the Hokkaido birth cohort study, Japan

  Sumitaka Kobayashi, Fumihiro Sata, Atsuko Ikeda-Araki, Chihiro Miyashita, Houman Goudarzi, Yusuke Iwasaki, Tamie Nakajima, Reiko Kishi

  Reproductive Toxicology 107 112 - 122 2022年01月 [査読有り]
  
• The association between prenatal perfluoroalkyl substance exposure and symptoms of attention-deficit/hyperactivity disorder in 8-year-old children and the mediating role of thyroid hormones in the Hokkaido study

  Sachiko Itoh, Keiko Yamazaki, Satoshi Suyama, Atsuko Ikeda-Araki, Chihiro Miyashita, Yu Ait Bamai, Sumitaka Kobayashi, Hideyuki Masuda, Takeshi Yamaguchi, Houman Goudarzi, Emiko Okada, Ikuko Kashino, Takuya Saito, Reiko Kishi

  Environment International 159 107026 - 107026 2022年01月 [査読有り]
  
• Associations between maternal mono-(2-ethylhexyl) phthalate levels, nuclear receptor gene polymorphisms, and fatty acid levels in pregnant Japanese women in the Hokkaido study

  Sumitaka Kobayashi, Fumihiro Sata, Chihiro Miyashita, Atsuko Ikeda-Araki, Houman Goudarzi, Tamie Nakajima, Reiko Kishi

  Reproductive Toxicology 107 22 - 32 2022年01月
• Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019: A Systematic Analysis for the Global Burden of Disease Study 2019.

  Jonathan M Kocarnik, Kelly Compton, Frances E Dean, Weijia Fu, Brian L Gaw, James D Harvey, Hannah Jacqueline Henrikson, Dan Lu, Alyssa Pennini, Rixing Xu, Emad Ababneh, Mohsen Abbasi-Kangevari, Hedayat Abbastabar, Sherief M Abd-Elsalam, Amir Abdoli, Aidin Abedi, Hassan Abidi, Hassan Abolhassani, Isaac Akinkunmi Adedeji, Qorinah Estiningtyas Sakilah Adnani, Shailesh M Advani, Muhammad Sohail Afzal, Mohammad Aghaali, Bright Opoku Ahinkorah, Sajjad Ahmad, Tauseef Ahmad, Ali Ahmadi, Sepideh Ahmadi, Tarik Ahmed Rashid, Yusra Ahmed Salih, Gizachew Taddesse Akalu, Addis Aklilu, Tayyaba Akram, Chisom Joyqueenet Akunna, Hanadi Al Hamad, Fares Alahdab, Ziyad Al-Aly, Saqib Ali, Yousef Alimohamadi, Vahid Alipour, Syed Mohamed Aljunid, Motasem Alkhayyat, Amir Almasi-Hashiani, Nihad A Almasri, Sadeq Ali Ali Al-Maweri, Sami Almustanyir, Nivaldo Alonso, Nelson Alvis-Guzman, Hubert Amu, Etsay Woldu Anbesu, Robert Ancuceanu, Fereshteh Ansari, Alireza Ansari-Moghaddam, Maxwell Hubert Antwi, Davood Anvari, Anayochukwu Edward Anyasodor, Muhammad Aqeel, Jalal Arabloo, Morteza Arab-Zozani, Olatunde Aremu, Hany Ariffin, Timur Aripov, Muhammad Arshad, Al Artaman, Judie Arulappan, Zatollah Asemi, Mohammad Asghari Jafarabadi, Tahira Ashraf, Prince Atorkey, Avinash Aujayeb, Marcel Ausloos, Atalel Fentahun Awedew, Beatriz Paulina Ayala Quintanilla, Temesgen Ayenew, Mohammed A Azab, Sina Azadnajafabad, Amirhossein Azari Jafari, Ghasem Azarian, Ahmed Y Azzam, Ashish D Badiye, Saeed Bahadory, Atif Amin Baig, Jennifer L Baker, Senthilkumar Balakrishnan, Maciej Banach, Till Winfried Bärnighausen, Francesco Barone-Adesi, Fabio Barra, Amadou Barrow, Masoud Behzadifar, Uzma Iqbal Belgaumi, Woldesellassie M Mequanint Bezabhe, Yihienew Mequanint Bezabih, Devidas S Bhagat, Akshaya Srikanth Bhagavathula, Nikha Bhardwaj, Pankaj Bhardwaj, Sonu Bhaskar, Krittika Bhattacharyya, Vijayalakshmi S Bhojaraja, Sadia Bibi, Ali Bijani, Antonio Biondi, Catherine Bisignano, Tone Bjørge, Archie Bleyer, Oleg Blyuss, Obasanjo Afolabi Bolarinwa, Srinivasa Rao Bolla, Dejana Braithwaite, Amanpreet Brar, Hermann Brenner, Maria Teresa Bustamante-Teixeira, Nadeem Shafique Butt, Zahid A Butt, Florentino Luciano Caetano Dos Santos, Yin Cao, Giulia Carreras, Ferrán Catalá-López, Francieli Cembranel, Ester Cerin, Achille Cernigliaro, Raja Chandra Chakinala, Soosanna Kumary Chattu, Vijay Kumar Chattu, Pankaj Chaturvedi, Odgerel Chimed-Ochir, Daniel Youngwhan Cho, Devasahayam J Christopher, Dinh-Toi Chu, Michael T Chung, Joao Conde, Sanda Cortés, Paolo Angelo Cortesi, Vera Marisa Costa, Amanda Ramos Cunha, Omid Dadras, Amare Belachew Dagnew, Saad M A Dahlawi, Xiaochen Dai, Lalit Dandona, Rakhi Dandona, Aso Mohammad Darwesh, José das Neves, Fernando Pio De la Hoz, Asmamaw Bizuneh Demis, Edgar Denova-Gutiérrez, Deepak Dhamnetiya, Mandira Lamichhane Dhimal, Meghnath Dhimal, Mostafa Dianatinasab, Daniel Diaz, Shirin Djalalinia, Huyen Phuc Do, Saeid Doaei, Fariba Dorostkar, Francisco Winter Dos Santos Figueiredo, Tim Robert Driscoll, Hedyeh Ebrahimi, Sahar Eftekharzadeh, Maha El Tantawi, Hassan El-Abid, Iffat Elbarazi, Hala Rashad Elhabashy, Muhammed Elhadi, Shaimaa I El-Jaafary, Babak Eshrati, Sharareh Eskandarieh, Firooz Esmaeilzadeh, Arash Etemadi, Sayeh Ezzikouri, Mohammed Faisaluddin, Emerito Jose A Faraon, Jawad Fares, Farshad Farzadfar, Abdullah Hamid Feroze, Simone Ferrero, Lorenzo Ferro Desideri, Irina Filip, Florian Fischer, James L Fisher, Masoud Foroutan, Takeshi Fukumoto, Peter Andras Gaal, Mohamed M Gad, Muktar A Gadanya, Silvano Gallus, Mariana Gaspar Fonseca, Abera Getachew Obsa, Mansour Ghafourifard, Ahmad Ghashghaee, Nermin Ghith, Maryam Gholamalizadeh, Syed Amir Gilani, Themba G Ginindza, Abraham Tamirat T Gizaw, James C Glasbey, Mahaveer Golechha, Pouya Goleij, Ricardo Santiago Gomez, Sameer Vali Gopalani, Giuseppe Gorini, Houman Goudarzi, Giuseppe Grosso, Mohammed Ibrahim Mohialdeen Gubari, Maximiliano Ribeiro Guerra, Avirup Guha, D Sanjeeva Gunasekera, Bhawna Gupta, Veer Bala Gupta, Vivek Kumar Gupta, Reyna Alma Gutiérrez, Nima Hafezi-Nejad, Mohammad Rifat Haider, Arvin Haj-Mirzaian, Rabih Halwani, Randah R Hamadeh, Sajid Hameed, Samer Hamidi, Asif Hanif, Shafiul Haque, Netanja I Harlianto, Josep Maria Haro, Ahmed I Hasaballah, Soheil Hassanipour, Roderick J Hay, Simon I Hay, Khezar Hayat, Golnaz Heidari, Mohammad Heidari, Brenda Yuliana Herrera-Serna, Claudiu Herteliu, Kamal Hezam, Ramesh Holla, Md Mahbub Hossain, Mohammad Bellal Hossain Hossain, Mohammad-Salar Hosseini, Mostafa Hosseini, Mehdi Hosseinzadeh, Mihaela Hostiuc, Sorin Hostiuc, Mowafa Househ, Mohamed Hsairi, Junjie Huang, Fernando N Hugo, Rabia Hussain, Nawfal R Hussein, Bing-Fang Hwang, Ivo Iavicoli, Segun Emmanuel Ibitoye, Fidelia Ida, Kevin S Ikuta, Olayinka Stephen Ilesanmi, Irena M Ilic, Milena D Ilic, Lalu Muhammad Irham, Jessica Y Islam, Rakibul M Islam, Sheikh Mohammed Shariful Islam, Nahlah Elkudssiah Ismail, Gaetano Isola, Masao Iwagami, Louis Jacob, Vardhmaan Jain, Mihajlo B Jakovljevic, Tahereh Javaheri, Shubha Jayaram, Seyed Behzad Jazayeri, Ravi Prakash Jha, Jost B Jonas, Tamas Joo, Nitin Joseph, Farahnaz Joukar, Mikk Jürisson, Ali Kabir, Danial Kahrizi, Leila R Kalankesh, Rohollah Kalhor, Feroze Kaliyadan, Yogeshwar Kalkonde, Ashwin Kamath, Nawzad Kameran Al-Salihi, Himal Kandel, Neeti Kapoor, André Karch, Ayele Semachew Kasa, Srinivasa Vittal Katikireddi, Joonas H Kauppila, Taras Kavetskyy, Sewnet Adem Kebede, Pedram Keshavarz, Mohammad Keykhaei, Yousef Saleh Khader, Rovshan Khalilov, Gulfaraz Khan, Maseer Khan, Md Nuruzzaman Khan, Moien A B Khan, Young-Ho Khang, Amir M Khater, Maryam Khayamzadeh, Gyu Ri Kim, Yun Jin Kim, Adnan Kisa, Sezer Kisa, Katarzyna Kissimova-Skarbek, Jacek A Kopec, Rajasekaran Koteeswaran, Parvaiz A Koul, Sindhura Lakshmi Koulmane Laxminarayana, Ai Koyanagi, Burcu Kucuk Bicer, Nuworza Kugbey, G Anil Kumar, Narinder Kumar, Nithin Kumar, Om P Kurmi, Tezer Kutluk, Carlo La Vecchia, Faris Hasan Lami, Iván Landires, Paolo Lauriola, Sang-Woong Lee, Shaun Wen Huey Lee, Wei-Chen Lee, Yo Han Lee, James Leigh, Elvynna Leong, Jiarui Li, Ming-Chieh Li, Xuefeng Liu, Joana A Loureiro, Raimundas Lunevicius, Muhammed Magdy Abd El Razek, Azeem Majeed, Alaa Makki, Shilpa Male, Ahmad Azam Malik, Mohammad Ali Mansournia, Santi Martini, Seyedeh Zahra Masoumi, Prashant Mathur, Martin McKee, Ravi Mehrotra, Walter Mendoza, Ritesh G Menezes, Endalkachew Worku Mengesha, Mohamed Kamal Mesregah, Tomislav Mestrovic, Junmei Miao Jonasson, Bartosz Miazgowski, Tomasz Miazgowski, Irmina Maria Michalek, Ted R Miller, Hamed Mirzaei, Hamid Reza Mirzaei, Sanjeev Misra, Prasanna Mithra, Masoud Moghadaszadeh, Karzan Abdulmuhsin Mohammad, Yousef Mohammad, Mokhtar Mohammadi, Seyyede Momeneh Mohammadi, Abdollah Mohammadian-Hafshejani, Shafiu Mohammed, Nagabhishek Moka, Ali H Mokdad, Mariam Molokhia, Lorenzo Monasta, Mohammad Ali Moni, Mohammad Amin Moosavi, Yousef Moradi, Paula Moraga, Joana Morgado-da-Costa, Shane Douglas Morrison, Abbas Mosapour, Sumaira Mubarik, Lillian Mwanri, Ahamarshan Jayaraman Nagarajan, Shankar Prasad Nagaraju, Chie Nagata, Mukhammad David Naimzada, Vinay Nangia, Atta Abbas Naqvi, Sreenivas Narasimha Swamy, Rawlance Ndejjo, Sabina O Nduaguba, Ionut Negoi, Serban Mircea Negru, Sandhya Neupane Kandel, Cuong Tat Nguyen, Huong Lan Thi Nguyen, Robina Khan Niazi, Chukwudi A Nnaji, Nurulamin M Noor, Virginia Nuñez-Samudio, Chimezie Igwegbe Nzoputam, Bogdan Oancea, Chimedsuren Ochir, Oluwakemi Ololade Odukoya, Felix Akpojene Ogbo, Andrew T Olagunju, Babayemi Oluwaseun Olakunde, Emad Omar, Ahmed Omar Bali, Abidemi E Emmanuel Omonisi, Sokking Ong, Obinna E Onwujekwe, Hans Orru, Doris V Ortega-Altamirano, Nikita Otstavnov, Stanislav S Otstavnov, Mayowa O Owolabi, Mahesh P A, Jagadish Rao Padubidri, Keyvan Pakshir, Adrian Pana, Demosthenes Panagiotakos, Songhomitra Panda-Jonas, Shahina Pardhan, Eun-Cheol Park, Eun-Kee Park, Fatemeh Pashazadeh Kan, Harsh K Patel, Jenil R Patel, Siddhartha Pati, Sanjay M Pattanshetty, Uttam Paudel, David M Pereira, Renato B Pereira, Arokiasamy Perianayagam, Julian David Pillay, Saeed Pirouzpanah, Farhad Pishgar, Indrashis Podder, Maarten J Postma, Hadi Pourjafar, Akila Prashant, Liliana Preotescu, Mohammad Rabiee, Navid Rabiee, Amir Radfar, Raghu Anekal Radhakrishnan, Venkatraman Radhakrishnan, Ata Rafiee, Fakher Rahim, Shadi Rahimzadeh, Mosiur Rahman, Muhammad Aziz Rahman, Amir Masoud Rahmani, Nazanin Rajai, Aashish Rajesh, Ivo Rakovac, Pradhum Ram, Kiana Ramezanzadeh, Kamal Ranabhat, Priyanga Ranasinghe, Chythra R Rao, Sowmya J Rao, Reza Rawassizadeh, Mohammad Sadegh Razeghinia, Andre M N Renzaho, Negar Rezaei, Nima Rezaei, Aziz Rezapour, Thomas J Roberts, Jefferson Antonio Buendia Rodriguez, Peter Rohloff, Michele Romoli, Luca Ronfani, Gholamreza Roshandel, Godfrey M Rwegerera, Manjula S, Siamak Sabour, Basema Saddik, Umar Saeed, Amirhossein Sahebkar, Harihar Sahoo, Sana Salehi, Marwa Rashad Salem, Hamideh Salimzadeh, Mehrnoosh Samaei, Abdallah M Samy, Juan Sanabria, Senthilkumar Sankararaman, Milena M Santric-Milicevic, Yaeesh Sardiwalla, Arash Sarveazad, Brijesh Sathian, Monika Sawhney, Mete Saylan, Ione Jayce Ceola Schneider, Mario Sekerija, Allen Seylani, Omid Shafaat, Zahra Shaghaghi, Masood Ali Shaikh, Erfan Shamsoddin, Mohammed Shannawaz, Rajesh Sharma, Aziz Sheikh, Sara Sheikhbahaei, Adithi Shetty, Jeevan K Shetty, Pavanchand H Shetty, Kenji Shibuya, Reza Shirkoohi, K M Shivakumar, Velizar Shivarov, Soraya Siabani, Sudeep K Siddappa Malleshappa, Diego Augusto Santos Silva, Jasvinder A Singh, Yitagesu Sintayehu, Valentin Yurievich Skryabin, Anna Aleksandrovna Skryabina, Matthew J Soeberg, Ahmad Sofi-Mahmudi, Houman Sotoudeh, Paschalis Steiropoulos, Kurt Straif, Ranjeeta Subedi, Mu'awiyyah Babale Sufiyan, Iyad Sultan, Saima Sultana, Daniel Sur, Viktória Szerencsés, Miklós Szócska, Rafael Tabarés-Seisdedos, Takahiro Tabuchi, Hooman Tadbiri, Amir Taherkhani, Ken Takahashi, Iman M Talaat, Ker-Kan Tan, Vivian Y Tat, Bemnet Amare A Tedla, Yonas Getaye Tefera, Arash Tehrani-Banihashemi, Mohamad-Hani Temsah, Fisaha Haile Tesfay, Gizachew Assefa Tessema, Rekha Thapar, Aravind Thavamani, Viveksandeep Thoguluva Chandrasekar, Nihal Thomas, Hamid Reza Tohidinik, Mathilde Touvier, Marcos Roberto Tovani-Palone, Eugenio Traini, Bach Xuan Tran, Khanh Bao Tran, Mai Thi Ngoc Tran, Jaya Prasad Tripathy, Biruk Shalmeno Tusa, Irfan Ullah, Saif Ullah, Krishna Kishore Umapathi, Bhaskaran Unnikrishnan, Era Upadhyay, Marco Vacante, Maryam Vaezi, Sahel Valadan Tahbaz, Diana Zuleika Velazquez, Massimiliano Veroux, Francesco S Violante, Vasily Vlassov, Bay Vo, Victor Volovici, Giang Thu Vu, Yasir Waheed, Richard G Wamai, Paul Ward, Yi Feng Wen, Ronny Westerman, Andrea Sylvia Winkler, Lalit Yadav, Seyed Hossein Yahyazadeh Jabbari, Lin Yang, Sanni Yaya, Taklo Simeneh Yazie Yazie, Yigizie Yeshaw, Naohiro Yonemoto, Mustafa Z Younis, Zabihollah Yousefi, Chuanhua Yu, Deniz Yuce, Ismaeel Yunusa, Vesna Zadnik, Fariba Zare, Mikhail Sergeevich Zastrozhin, Anasthasia Zastrozhina, Jianrong Zhang, Chenwen Zhong, Linghui Zhou, Cong Zhu, Arash Ziapour, Ivan R Zimmermann, Christina Fitzmaurice, Christopher J L Murray, Lisa M Force

  JAMA oncology 8 3 420 - 444 2021年12月30日 

  Importance: The Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019) provided systematic estimates of incidence, morbidity, and mortality to inform local and international efforts toward reducing cancer burden. Objective: To estimate cancer burden and trends globally for 204 countries and territories and by Sociodemographic Index (SDI) quintiles from 2010 to 2019. Evidence Review: The GBD 2019 estimation methods were used to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life years (DALYs) in 2019 and over the past decade. Estimates are also provided by quintiles of the SDI, a composite measure of educational attainment, income per capita, and total fertility rate for those younger than 25 years. Estimates include 95% uncertainty intervals (UIs). Findings: In 2019, there were an estimated 23.6 million (95% UI, 22.2-24.9 million) new cancer cases (17.2 million when excluding nonmelanoma skin cancer) and 10.0 million (95% UI, 9.36-10.6 million) cancer deaths globally, with an estimated 250 million (235-264 million) DALYs due to cancer. Since 2010, these represented a 26.3% (95% UI, 20.3%-32.3%) increase in new cases, a 20.9% (95% UI, 14.2%-27.6%) increase in deaths, and a 16.0% (95% UI, 9.3%-22.8%) increase in DALYs. Among 22 groups of diseases and injuries in the GBD 2019 study, cancer was second only to cardiovascular diseases for the number of deaths, years of life lost, and DALYs globally in 2019. Cancer burden differed across SDI quintiles. The proportion of years lived with disability that contributed to DALYs increased with SDI, ranging from 1.4% (1.1%-1.8%) in the low SDI quintile to 5.7% (4.2%-7.1%) in the high SDI quintile. While the high SDI quintile had the highest number of new cases in 2019, the middle SDI quintile had the highest number of cancer deaths and DALYs. From 2010 to 2019, the largest percentage increase in the numbers of cases and deaths occurred in the low and low-middle SDI quintiles. Conclusions and Relevance: The results of this systematic analysis suggest that the global burden of cancer is substantial and growing, with burden differing by SDI. These results provide comprehensive and comparable estimates that can potentially inform efforts toward equitable cancer control around the world.
• Measuring routine childhood vaccination coverage in 204 countries and territories, 1980-2019: a systematic analysis for the Global Burden of Disease Study 2020, Release 1

  GBD Release, Vaccine Coverage Collaborators including, Houman Goudarzi

  Lancet 398 10299 503 - 521 2021年08月 [査読有り]
  
• Associations among maternal perfluoroalkyl substance levels, fetal sex-hormone enzymatic gene polymorphisms, and fetal sex hormone levels in the Hokkaido study

  Sumitaka Kobayashi, Fumihiro Sata, Atsuko Ikeda-Araki, Chihiro Miyashita, Sachiko Itoh, Houman Goudarzi, Yusuke Iwasaki, Takahiko Mitsui, Kimihiko Moriya, Nobuo Shinohara, Kazutoshi Cho, Reiko Kishi

  Reproductive Toxicology 105 221 - 231 2021年06月 [査読有り]
  
• Association of abdominal visceral adiposity with sputum IL-5 levels in asthma

  Houman Goudarzi, Hirokazu Kimura, Hironi Makita, Yuki Abe, Akira Oguma, Michiko Sato, Munehiro Matsumoto, Nozomu Takei, Hiroki Kimura, Kaoruko Shimizu, Masaru Suzuki, Yoichi M Ito, Masaharu Nishimura, Satoshi Konno

  Allergology International S1323-8930 21 9 - 95 2021年06月 [査読有り]
  
• Global, regional, and national progress towards Sustainable Development Goal 3.2 for neonatal and child health: all-cause and cause-specific mortality findings from the Global Burden of Disease Study 2019

  GBD Under-5 Mortality Collaborators including Houman Goudarzi

  Lancet 398 10303 870 - 905 2021年06月 [査読有り]
  
• Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and attributable disease burden in 204 countries and territories, 1990-2019: a systematic analysis from the Global Burden of Disease Study 2019

  GBD, Tobacco Collaborators including Houman Goudarzi

  Lancet 397 10292 2337 - 2360 2021年06月 [査読有り]
   

  Background: Ending the global tobacco epidemic is a defining challenge in global health. Timely and comprehensive estimates of the prevalence of smoking tobacco use and attributable disease burden are needed to guide tobacco control efforts nationally and globally. Methods: We estimated the prevalence of smoking tobacco use and attributable disease burden for 204 countries and territories, by age and sex, from 1990 to 2019 as part of the Global Burden of Diseases, Injuries, and Risk Factors Study. We modelled multiple smoking-related indicators from 3625 nationally representative surveys. We completed systematic reviews and did Bayesian meta-regressions for 36 causally linked health outcomes to estimate non-linear dose-response risk curves for current and former smokers. We used a direct estimation approach to estimate attributable burden, providing more comprehensive estimates of the health effects of smoking than previously available. Findings: Globally in 2019, 1·14 billion (95% uncertainty interval 1·13–1·16) individuals were current smokers, who consumed 7·41 trillion (7·11–7·74) cigarette-equivalents of tobacco in 2019. Although prevalence of smoking had decreased significantly since 1990 among both males (27·5% [26·5–28·5] reduction) and females (37·7% [35·4–39·9] reduction) aged 15 years and older, population growth has led to a significant increase in the total number of smokers from 0·99 billion (0·98–1·00) in 1990. Globally in 2019, smoking tobacco use accounted for 7·69 million (7·16–8·20) deaths and 200 million (185–214) disability-adjusted life-years, and was the leading risk factor for death among males (20·2% [19·3–21·1] of male deaths). 6·68 million [86·9%] of 7·69 million deaths attributable to smoking tobacco use were among current smokers. Interpretation: In the absence of intervention, the annual toll of 7·69 million deaths and 200 million disability-adjusted life-years attributable to smoking will increase over the coming decades. Substantial progress in reducing the prevalence of smoking tobacco use has been observed in countries from all regions and at all stages of development, but a large implementation gap remains for tobacco control. Countries have a clear and urgent opportunity to pass strong, evidence-based policies to accelerate reductions in the prevalence of smoking and reap massive health benefits for their citizens. Funding: Bloomberg Philanthropies and the Bill & Melinda Gates Foundation.
• Hokkaido birth cohort study on environment and children's health: cohort profile 2021

  Reiko Kishi, Atsuko Ikeda-Araki, Chihiro Miyashita, Sachiko Itoh, Sumitaka Kobayashi, Yu Ait Bamai, Keiko Yamazaki, Naomi Tamura, Machiko Minatoya, Rahel Mesfin Ketema, Kritika Poudel, Ryu Miura, Hideyuki Masuda, Mariko Itoh, Takeshi Yamaguchi, Hisanori Fukunaga, Kumiko Ito, Houman Goudarzi

  Environ Health Prev Med . 26 1 59  2021年05月 [査読有り]
  
• Associations among perfluorooctanesulfonic/perfluorooctanoic acid levels, nuclear receptor gene polymorphisms, and lipid levels in pregnant women in the Hokkaido study

  Sumitaka Kobayashi, Fumihiro Sata, Houman Goudarzi, Atsuko Araki, Chihiro Miyashita, Seiko Sasaki, Emiko Okada, Yusuke Iwasaki, Tamie Nakajima, Reiko Kishi

  Scientific Report 11 1 9994 - 9994 2021年05月 [査読有り]
   

  The effect of interactions between perfluorooctanesulfonic (PFOS)/perfluorooctanoic acid (PFOA) levels and nuclear receptor genotypes on fatty acid (FA) levels, including those of triglycerides, is not clear understood. Therefore, in the present study, we aimed to analyse the association of PFOS/PFOA levels and single-nucleotide polymorphisms (SNPs) in nuclear receptors with FA levels in pregnant women. We analysed 504 mothers in a birth cohort between 2002 and 2005 in Japan. Serum PFOS/PFOA and FA levels were measured using liquid chromatography-tandem mass spectrometry and gas chromatography-mass spectrometry. Maternal genotypes in PPARA (rs1800234; rs135561), PPARG (rs3856806), PPARGC1A (rs2970847; rs8192678), PPARD (rs1053049; rs2267668), CAR (rs2307424; rs2501873), LXRA (rs2279238) and LXRB (rs1405655; rs2303044; rs4802703) were analysed. When gene-environment interaction was considered, PFOS exposure (log10 scale) decreased palmitic, palmitoleic, and oleic acid levels (log10 scale), with the observed β in the range of - 0.452 to - 0.244; PPARGC1A (rs8192678) and PPARD (rs1053049; rs2267668) genotypes decreased triglyceride, palmitic, palmitoleic, and oleic acid levels, with the observed β in the range of - 0.266 to - 0.176. Interactions between PFOS exposure and SNPs were significant for palmitic acid (Pint = 0.004 to 0.017). In conclusion, the interactions between maternal PFOS levels and PPARGC1A or PPARD may modify maternal FA levels.
• Multidrug treatment for COVID-19

  Masashi Ohe, Ken Furuya, Houman Goudarzi

  Drug Discov Ther . 15 1 39 - 41 2021年03月 [査読有り]
  
• Tetracycline plus macrolide: A potential therapeutic regimen for COVID-19?

  Masashi Ohe, Ken Furuya, Houman Goudarzi

  Biosci Trends. 14 6 467 - 468 2021年01月 [査読有り]
  
• Determination of the cutoff values of Th2 markers for the prediction of future exacerbation in severe asthma: An analysis from the Hokkaido Severe Asthma Cohort Study

  Hirokazu Kimura, Hironi Makita, Natsuko Taniguchi, Nozomu Takei, Munehiro Matsumoto, Hiroki Kimura, Houman Goudarzi, Kaoruko Shimizu, Masaru Suzuki, Masaharu Nishimura, Satoshi Konno

  Allergology International 70 1 68 - 73 2021年01月 [査読有り]
  
• Five insights from the Global Burden of Disease Study 2019

  Cristiana Abbafati, Kaja M. Abbas, Mohammad Abbasi, Mitra Abbasifard, Mohsen Abbasi-Kangevari, Hedayat Abbastabar, Foad Abd-Allah, Ahmed Abdelalim, Mohammad Abdollahi, Ibrahim Abdollahpour, Aidin Abedi, Parisa Abedi, Kedir Hussein Abegaz, Hassan Abolhassani, Akine Eshete Abosetugn, Victor Aboyans, Elissa M. Abrams, Lucas Guimaraes Abreu, Michael R. M. Abrigo, Abdulaziz Khalid Abu Haimed, Ahmed Abualhasan, Eman Abu-Gharbieh, Laith Jamal Abu-Raddad, Abdelrahman I. Abushouk, Alyssa Acebedo, Ilana N. Ackerman, Maryam Adabi, Tim Adair, Abdu A. Adamu, Oladimeji M. Adebayo, Isaac Akinkunmi Adedeji, Victor Adekanmbi, Jaimie D. Adelson, Abiodun Moshood Adeoye, Olatunji O. Adetokunboh, Davoud Adham, Shailesh M. Advani, Mohsen Afarideh, Mahdi Afshari, Ashkan Afshin, Emilie E. Agardh, Gina Agarwal, Pradyumna Agasthi, Kareha M. Agesa, Mohammad Aghaali, Seyed Mohammad Kazem Aghamir, Anurag Agrawal, Tauseef Ahmad, Alireza Ahmadi, Keivan Ahmadi, Mehdi Ahmadi, Hamid Ahmadieh, Ehsan Ahmadpour, Muktar Beshir Ahmed, Budi Aji, Temesgen Yihunie Akalu, Rufus Olusola Akinyemi, Tomi Akinyemiju, Blessing Akombi, Chisom Joyqueenet Akunna, Fares Alahdab, Ziyad Al-Aly, Khurshid Alam, Noore Alam, Samiah Alam, Tahiya Alam, Fahad Mashhour Alanezi, Turki M. Alanzi, Samuel B. Albertson, Jacqueline Elizabeth Alcalde-Rabanal, Niguse Meles Alema, Biresaw Wassihun Alemu, Yihun Mulugeta Alemu, Khalid F. Alhabib, Robert Kaba Alhassan, Muhammad Ali, Saqib Ali, Gianfranco Alicandro, Mehran Alijanzadeh, Cyrus Alinia, Vahid Alipour, Hesam Alizade, Syed Mohamed Aljunid, Francois Alla, Peter Allebeck, Majid Abdulrahman Hamad Almadi, Ali Almasi, Amir Almasi-Hashiani, Nihad A. Almasri, Hesham M. Al-Mekhlafi, Abdulaziz M. Almulhim, Jordi Alonso, Rajaa M. Al-Raddadi, Khalid A. Altirkawi, Arwa Khalid Alumran, Nelson Alvis-Guzman, Nelson J. Alvis-Zakzuk, Azmeraw T. Amare, Bekalu Amare, Saeed Amini, Mostafa Amini-Rarani, Arya Aminorroaya, Fatemeh Amiri, Arianna Maever L. Amit, Dickson A. Amugsi, Gianna Gayle Herrera Amul, Etsay Woldu Anbesu, Robert Ancuceanu, Deanna Anderlini, Jason A. Anderson, Catalina Liliana Andrei, Tudorel Andrei, Sofia Androudi, Colin Angus, Mina Anjomshoa, Fereshteh Ansari, Iman Ansari, Alireza Ansari-Moghaddam, Ippazio Cosimo Antonazzo, Carl Abelardo T. Antonio, Catherine M. Antony, Ernoiz Antriyandarti, Davood Anvari, Razique Anwer, Seth Christopher Yaw Appiah, Jalal Arabloo, Morteza Arab-Zozani, Aleksandr Y. Aravkin, Aseb Arba Kinfe Arba, Olatunde Aremu, Filippo Ariani, Timur Aripov, Bahram Armoon, Johan Arnlov, Oluwaseyi Olalekan Arowosegbe, Krishna K. Aryal, Afsaneh Arzani, Malke Asaad, Mehran Asadi-Aliabadi, Ali A. Asadi-Pooya, Samaneh Asgari, Babak Asghari, Mohammad Asghari Jafarabadi, Charlie Ashbaugh, Michael Assmus, Zahra Atafar, Seyyed Shamsadin Athari, Desta Debalkie Atnafu, Maha Moh'd Wahbi Atout, Sachin R. Atre, Madhu Sudhan Atteraya, Floriane Ausloos, Marcel Ausloos, Leticia Avila-Burgos, Euripide Frinel Gbenato Arthur Avokpaho, Beatriz Paulina Ayala Quintanilla, Getinet Ayano, Martin Amogre Ayanore, Getie Lake Aynalem, Yared Asmare Aynalem, Muluken Altaye Ayza, Samad Azari, Ghasem Azarian, Zelalem Nigussie Azene, Gulrez Azhar, Peter S. Azzopardi, B. B. Darshan, Ebrahim Babaee, Alaa Badawi, Ashish D. Badiye, Mojtaba Bagherzadeh, Eleni Bagli, Mohammad Amin Bahrami, Atif Amin Baig, Mohan Bairwa, Mohammad Hossein Bakhshaei, Ahad Bakhtiari, Shankar M. Bakkannavar, Arun Balachandran, Senthilkumar Balakrishnan, Shivanthi Balalla, Shelly Balassyano, Alberto Baldasseroni, Kylie Ball, Shoshana H. Ballew, Daniela Balzi, Maciej Banach, Srikanta K. Banerjee, Palash Chandra Banik, Marlena S. Bannick, Agegnehu Bante Bante, Simachew Animen Bante, Adhanom Gebreegziabher Baraki, Miguel A. Barboza, Suzanne Lyn Barker-Collo, Till Winfried Barnighausen, Lope H. Barrero, Celine M. Barthelemy, Lingkan Barua, Akbar Barzegar, Huda Basaleem, Quique Bassat, Sanjay Basu, Bernhard T. Baune, Mohsen Bayati, Bayisa Abdissa Baye, Gholamreza Bazmandegan, Jacob S. Becker, Neeraj Bedi, Ettore Beghi, Masoud Behzadifar, Yannick Bejot, Tariku Tesfaye Tesfaye Bekuma, Michelle L. Bell, Aminu K. Bello, Rose G. Bender, Derrick A. Bennett, Fiona B. Bennitt, Isabela M. Bensenor, Catherine P. Benziger, Kidanemaryam Berhe, Adam E. Berman, Eduardo Bernabe, Robert S. Bernstein, Gregory J. Bertolacci, Akshaya Srikanth Bhagavathula, Reshmi Bhageerathy, Neeraj Bhala, Dinesh Bhandari, Pankaj Bhardwaj, Anusha Ganapati Bhat, Krittika Bhattacharyya, Suraj Bhattarai, Zulfiqar A. Bhutta, Sadia Bibi, Molly H. Biehl, Ali Bijani, Boris Bikbov, Ver Bilano, Muhammad Shahdaat Bin Sayeed, Antonio Biondi, Binyam Minuye Birihane, Donal Bisanzio, Catherine Bisignano, Raaj Kishore Biswas, Helen Bitew, Tone Bjorge, Moses John Bockarie, Somayeh Bohlouli, Mehdi Bohluli, Hunduma Amensisa Bojia, Srinivasa Rao Bolla, Archith Boloor, Alexandra S. Boon-Dooley, Guilherme Borges, Antonio Maria Borzi, Shiva Borzouei, Dipan Bose, Cristina Bosetti, Soufiane Boufous, Rupert Bourne, Oliver J. Brady, Dejana Braithwaite, Michael Brauer, Carol Brayne, Nicholas J. K. Breitborde, Susanne Breitner, Hermann Brenner, Alexey V. Breusov, Paul Svitil Briant, Andrew M. Briggs, Andrey Nikolaevich Briko, Nikolay Ivanovich Briko, Gabrielle B. Britton, Traolach Brugha, Dana Bryazka, Rachelle Buchbinder, Blair R. Bumgarner, Katrin Burkart, Richard Thomas Burnett, Sharath Burugina Nagaraja, Reinhard Busse, Zahid A. Butt, Florentino Luciano Caetano dos Santos, Leah E. Cahill, Lucero Cahuana-Hurtado, Tianji Cai, Charlton S. K. H. Callender, Luis Alberto Camera, Ismael R. Campos-Nonato, Julio Cesar Campuzano Rincon, Jackie Cao, Josip Car, Rosario Cardenas, Giulia Carreras, Juan J. Carrero, Felix Carvalho, Joao Mauricio Castaldelli-Maia, Carlos A. Castaneda-Orjuela, Giulio Castelpietra, Chris D. Castle, Emma Castro, Franz Castro, Ferran Catala-Lopez, Kate Causey, Christopher R. Cederroth, Kelly M. Cercy, Ester Cerin, Julian Chalek, Joht Singh Chandan, Alex R. Chang, Angela Y. Chang, Jung-Chen Chang, Kai-Lan Chang, Jaykaran Charan, Fiona J. Charlson, Vijay Kumar Chattu, Sarika Chaturvedi, Nicolas Cherbuin, Odgerel Chimed-Ochir, Ken Lee Chin, Jesus Lorenzo Chirinos-Caceres, Daniel Youngwhan Cho, Jee-Young Jasmine Choi, Hanne Christensen, Dinh-Toi Chu, Michael T. Chung, Sheng-Chia Chung, Flavia M. Cicuttini, Liliana G. Ciobanu, Massimo Cirillo, Beniamino Cislaghi, Thomas Khaled Dwayne Classen, Aaron J. Cohen, Emma L. Collins, Haley Comfort, Kelly Compton, Sara Conti, Owen R. Cooper, Barbara Corso, Paolo Angelo Cortesi, Vera Marisa Costa, Ewerton Cousin, Richard G. Cowden, Benjamin C. Cowie, Elizabeth A. Cromwell, Andrew J. Croneberger, Di H. Cross, Marita Cross, Christopher Stephen Crowe, Jessica A. Cruz, Steven Cummins, Matthew Cunningham, Saad M. A. Dahlawi, Haijiang Dai, Hancheng Dai, Albertino Antonio Moura Damasceno, Giovanni Damiani, Emanuele D'Amico, Lalit Dandona, Rakhi Dandona, Parnaz Daneshpajouhnejad, William James Dangel, Anna-Karin Danielsson, Jiregna Darega Gela, Paul I. Dargan, Aso Mohammad Darwesh, Ahmad Daryani, Jai K. Das, Rajat Das Gupta, Jose Das Neves, Aditya Prasad Dash, Gail Davey, Claudio Alberto Davila-Cervantes, Adrian C. Davis, Dragos Virgil Davitoiu, Kairat Davletov, Diego De Leo, Jan-Walter De Neve, Frances E. Dean, Nicole K. DeCleene, Amanda Deen, Louisa Degenhardt, Marissa DeLang, Robert Paul Dellavalle, Feleke Mekonnen Demeke, Gebre Teklemariam Demoz, Desalegn Getnet Demsie, Edgar Denova-Gutierrez, Nebiyu Dereje Dereje, Kebede Deribe, Nikolaos Dervenis, Rupak Desai, Assefa Desalew, Getenet Ayalew Dessie, Keshab Deuba, Samath Dhamminda Dharmaratne, Govinda Prasad Dhungana, Mostafa Dianatinasab, Diana Dias da Silva, Daniel Diaz, Zahra Sadat Dibaji Forooshani, Martin Dichgans, Alireza Didarloo, Zachary V. Dingels, Ilse N. Dippenaar, M. Ashworth Dirac, Shirin Djalalinia, Hoa Thi Do, Klara Dokova, David Teye Doku, Christiane Dolecek, Andrew J. Dolgert, Fariba Dorostkar, Chirag P. Doshi, Pratik P. Doshi, Leila Doshmangir, Abdel Douiri, Matthew C. Doxey, Kerrie E. Doyle, Tim Robert Driscoll, Eleonora Dubljanin, Susanna J. Dunachie, Bruce B. Duncan, Andre Rodrigues Duraes, Arielle Wilder Eagan, Hedyeh Ebrahimi, Mohammad Ebrahimi Kalan, David Edvardsson, Andem Effiong, Joshua R. Ehrlich, Nevine El Nahas, Iman El Sayed, Maysaa El Sayed Zaki, Maha El Tantawi, Iffat Elbarazi, Islam Y. Elgendy, Hala Rashad Elhabashy, Shaimaa I. El-Jaafary, Aisha Elsharkawy, Iqbal R. F. Elyazar, Mohammad Hassan Emamian, Sophia Emmons-Bell, Holly E. Erskine, Babak Eshrati, Khalil Eskandari, Sharareh Eskandarieh, Saman Esmaeilnejad, Firooz Esmaeilzadeh, Alireza Esteghamati, Sadaf Esteghamati, Kara Estep, Arash Etemadi, Atkilt Esaiyas Etisso, Oluchi Ezekannagha, Jessica Fanzo, Tamer Farag, Mohammad Farahmand, Anwar Faraj, Emerito Jose A. Faraon, Mohammad Fareed, Roghiyeh Faridnia, Carla Sofia e Sa Farinha, Andrea Farioli, Pawan Sirwan Faris, Andre Faro, Mithila Faruque, Farshad Farzadfar, Nazir Fattahi, Ali Akbar Fazaeli, Mehdi Fazlzadeh, Valery L. Feigin, Rachel Feldman, Seyed-Mohammad Fereshtehnejad, Eduarda Fernandes, Giannina Ferrara, Pietro Ferrara, Alize J. Ferrari, Manuela L. Ferreira, Garumma Tolu Feyissa, Irina Filip, Florian Fischer, James L. Fisher, Ryan Fitzgerald, Carsten Flohr, Luisa Sorio Flor, Nataliya A. Foigt, Morenike Oluwatoyin Folayan, Artem Alekseevich Fomenkov, Lisa M. Force, Carla Fornari, Masoud Foroutan, Jack T. Fox, Joel Msafiri Francis, Tahvi D. Frank, Richard Charles Franklin, Marisa Freitas, Weijia Fu, Takeshi Fukumoto, Kai Fukutaki, John E. Fuller, Nancy Fullman, Joao M. Furtado, Mohamed M. Gad, Abhay Motiramji Gaidhane, Emmanuela Gakidou, Natalie C. Galles, Silvano Gallus, Amiran Gamkrelidze, Alberto L. Garcia-Basteiro, William M. Gardner, Biniyam Sahiledengle Geberemariyam, Abiyu Mekonnen Gebrehiwot, Ketema Bizuwork Gebremedhin, Gebreamlak Gebremedhn Gebremeskel, Leake G. Gebremeskel, Begashaw Melaku Gebresillassie, Assefa Ayalew Ayalew Ayalew Gebreslassie, Yilma Chisha Dea Geramo, Abraham Geremew, Anna Gershberg Hayoon, Hailay Abrha Gesesew, Peter W. Gething, Kebede Embaye Gezae, Maryam Ghadimi, Keyghobad Ghadiri, Fatemeh Ghaffarifar, Mansour Ghafourifard, Alireza Ghajar, Farhad Ghamari, Ahmad Ghashghaee, Hesam Ghiasvand, Nermin Ghith, Asadollah Gholamian, Rakesh Ghosh, Simona Giampaoli, Syed Amir Gilani, Paramjit Singh Gill, Tiffany K. Gill, Richard F. Gillum, Ibrahim Abdelmageed Ginawi, Themba G. Ginindza, Mojgan Gitimoghaddam, Giorgia Giussani, Mustefa Glagn, Ekaterina Vladimirovna Glushkova, Elena V. Gnedovskaya, Myron Anthony Godinho, Salime Goharinezhad, Mahaveer Golechha, Srinivas Goli, Ricardo Santiago Gomez, Philimon N. Gona, Sameer Vali Gopalani, Emily Goren, Giuseppe Gorini, Taren M. Gorman, Harrison Chase Gottlich, Houman Goudarzi, Amir Hossein Goudarzian, Alessandra C. Goulart, Barbara Niegia Garcia Goulart, Ayman Grada, Felix Greaves, Michal Grivna, Giuseppe Grosso, Mohammed Ibrahim Mohialdeen Gubari, Nachiket Gudi, Harish Chander Gugnani, Andre Luiz Sena Guimaraes, Rafael Alves Guimaraes, Rashid Abdi Guled, Teklemariam Gultie, Gaorui Guo, Yuming Guo, Rahul Gupta, Rajeev Gupta, Subodh Sharan, Tarun Gupta, Juanita A. Haagsma, Vladimir Hachinski, Beatrix Haddock, Nima Hafezi-Nejad, Abdul Hafiz, Hailey Hagins, Lydia M. Haile, Teklehaimanot Gereziher Haile, Arvin Haj-Mirzaian, Arya Haj-Mirzaian, Brian J. Hall, Iman Halvaei, Randah R. Hamadeh, Kanaan Hamagharib Abdullah, Sajid Hameed, Samer Hamidi, Erin B. Hamilton, Melanie S. Hammer, Chieh Han, Hannah Han, Demelash Woldeyohannes Handiso, Asif Hanif, Graeme J. Hankey, Hamidreza Haririan, Josep Maria Haro, James D. Harvey, Ahmed I. Hasaballah, Md Mehedi Hasan, Edris Hasanpoor, Amir Hasanzadeh, Maryam Hashemian, Abdiwahab Hashi, Amr Hassan, Shoaib Hassan, Soheil Hassanipour, Hadi Hassankhani, Rasmus J. Havmoeller, Roderick J. Hay, Simon I. Hay, Khezar Hayat, Behzad Heibati, Behnam Heidari, Golnaz Heidari, Reza Heidari-Soureshjani, Delia Hendrie, Kiana Henny, Andualem Henok, Hannah J. Henrikson, Nathaniel J. Henry, Molly E. Herbert, Claudiu Herteliu, Fatemeh Heydarpour, Thomas R. Hird, Hung Chak Ho, Hans W. Hoek, Michael K. Hole, Ramesh Holla, Bruce Hollingsworth, Praveen Hoogar, Kathleen Pillsbury Hopf, Nobuyuki Horita, H. Dean Hosgood, Naznin Hossain, Mostafa Hosseini, Mehdi Hosseinzadeh, Mihaela Hostiuc, Sorin Hostiuc, Mowafa Househ, Damian G. Hoy, Mohamed Hsairi, Thomas Hsiao, Vivian Chia-Rong Hsieh, Guoqing Hu, Kejia Hu, Tanvir M. Huda, Fernando N. Hugo, Ayesha Humayun, Rabia Hussain, Chantal K. Huynh, Bing-Fang Hwang, Vincent C. Iannucci, Ivo Iavicoli, Charles Ugochukwu Ibeneme, Segun Emmanuel Ibitoye, Nayu Ikeda, Kevin S. Ikuta, Olayinka Stephen Ilesanmi, Irena M. Ilic, Milena D. Ilic, Mohammad Hasan Imani-Nasab, Leeberk Raja Inbaraj, Helen Ippolito, Usman Iqbal, Seyed Sina Naghibi Irvani, Caleb Mackay Salpeter Irvine, M. Mofizul Islam, MdMohaimenul Islam, Sheikh Mohammed Shariful Islam, Farhad Islami, Hiroyasu Iso, Rebecca Q. Ivers, Chidozie C. D. Iwu, Chinwe Juliana Iwu, Ihoghosa Osamuyi Iyamu, Jalil Jaafari, Kathryn H. Jacobsen, Farhad Jadidi-Niaragh, Hussain Jafari, Morteza Jafarinia, Deepa Jahagirdar, Mohammad Ali Jahani, Nader Jahanmehr, Mihajlo Jakovljevic, Amir Jalali, Farzad Jalilian, Spencer L. James, Hosna Janjani, Manthan Dilipkumar Janodia, Tahereh Javaheri, Javad Javidnia, Achala Upendra Jayatilleke, Panniyammakal Jeemon, Ensiyeh Jenabi, Ravi Prakash Jha, Vivekanand Jha, John S. Ji, Peng Jia, Lars Johansson, Oommen John, Yetunde O. John-Akinola, Catherine Owens Johnson, Sarah Charlotte Johnson, Jost B. Jonas, Tamas Joo, Ankur Joshi, Farahnaz Joukar, Jacek Jerzy Jozwiak, Mikk Jurisson, Ali Kabir, Zubair Kabir, Hamed Kalani, Rizwan Kalani, Leila R. Kalankesh, Rohollah Kalhor, Aruna M. Kamath, Zahra Kamiab, Tanuj Kanchan, Neeti Kapoor, Behzad Karami Matin, Marina Karanikolos, Andre Karch, Mohd Anisul Karim, Salah Eddin Karimi, Seyed Asaad Karimi, Seyed M. Karimi, Ayele Semachew Kasa, Getachew Mullu Kassa, Nicholas J. Kassebaum, Srinivasa Vittal Katikireddi, Norito Kawakami, Gbenga A. Kayode, Ali Kazemi Karyani, Suzanne H. Keddie, Peter Njenga Keiyoro, Cathleen Keller, Laura Kemmer, Parkes J. Kendrick, Maia Kereselidze, Yousef Saleh Khader, Morteza Abdullatif Khafaie, Nauman Khalid, Mohammad Khammarnia, Ejaz Ahmad Khan, Gulfaraz Khan, Maseer Khan, Young-Ho Khang, Khaled Khatab, Amir M. Khater, Mona M. Khater, Mahalaqua Nazli Khatib, Maryam Khayamzadeh, Salman Khazaei, Habibolah Khazaie, Mohammad Taghi Khodayari, Abdullah T. Khoja, Jagdish Khubchandani, Roba Khundkar, Neda Kianipour, Christian Kieling, Cho-Il Kim, Daniel Kim, Young-Eun Kim, Yun Jin Kim, Ruth W. Kimokoti, Yohannes Kinfu, Adnan Kisa, Sezer Kisa, Katarzyna Kissimova-Skarbek, Niranjan Kissoon, Mika Kivimaki, Cameron J. Kneib, Luke D. Knibbs, Megan Knight, Ann Kristin Skrindo Knudsen, Jonathan M. Kocarnik, Sonali Kochhar, David S. Q. Koh, Stefan Kohler, Tufa Kolola, Hamidreza Komaki, Jacek A. Kopec, Anna V. Korotkova, Vladimir Andreevich Korshunov, Soewarta Kosen, Anirudh Kotlo, Parvaiz A. Koul, Ai Koyanagi, Moritz U. G. Kraemer, Michael A. Kravchenko, Kewal Krishan, Kris J. Krohn, Hans Kromhout, K. S. Shaji, Barthelemy Kuate Defo, Burcu Kucuk Bicer, Nuworza Kugbey, Vaman Kulkarni, G. Anil Kumar, Manasi Kumar, Nithin Kumar, Pushpendra Kumar, Vivek Kumar, Girikumar Kumaresh, Om P. Kurmi, Dian Kusuma, Hmwe Hmwe Kyu, Carlo La Vecchia, Ben Lacey, Dharmesh Kumar Lal, Ratilal Lalloo, Tea Lallukka, Jennifer O. Lam, Faris Hasan Lami, Qing Lan, Ivan Landires, Justin J. Lang, Sinead M. Langan, Van Charles Lansingh, Sonia Lansky, Heidi Jane Larson, Samantha Leigh Larson, Anders O. Larsson, Savita Lasrado, Zohra S. Lassi, Kathryn Mei-Ming Lau, Paolo Lauriola, Pablo M. Lavados, Jeffrey V. Lazarus, Lisiane F. Leal, Janet L. Leasher, Jorge R. Ledesma, Paul H. Lee, Shaun Wen Huey Lee, Andrew T. Leever, Kate E. LeGrand, James Leigh, Matilde Leonardi, Haley Lescinsky, Janni Leung, Miriam Levi, Sarah Lewington, Bingyu Li, Shanshan Li, Lee-Ling Lim, Christine Lin, Ro-Ting Lin, Christine Linehan, Shai Linn, Stefan Listl, Hung-Chun Liu, Shiwei Liu, Simin Liu, Xuefeng Liu, Yang Liu, Zichen Liu, Justin Lo, Rakesh Lodha, Giancarlo Logroscino, Katharine J. Looker, Alan D. Lopez, Jaifred Christian F. Lopez, Platon D. Lopukhov, Stefan Lorkowski, Paulo A. Lotufo, Rafael Lozano, Alton Lu, Tim C. D. Lucas, Alessandra Lugo, Raimundas Lunevicius, Ronan A. Lyons, Jianing Ma, Daiane Borges Machado, Jennifer H. MacLachlan, Mohammed Madadin, Emilie R. Maddison, Ralph Maddison, Fabiana Madotto, Hassan Magdy Abd El Razek, Muhammed Magdy Abd El Razek, Phetole Walter Mahasha, Mokhtar Mahdavi Mahdavi, Morteza Mahmoudi, Hue Thi Mai, Azeem Majeed, Jeadran N. Malagon-Rojas, Venkatesh Maled, Afshin Maleki, Shokofeh Maleki, Reza Malekzadeh, Deborah Carvalho Malta, Abdullah A. Mamun, Amir Manafi, Navid Manafi, Ana Laura Manda, Helena Manguerra, Fariborz Mansour-Ghanaei, Borhan Mansouri, Mohammad Ali Mansournia, Ana M. Mantilla Herrera, Chabila Christopher Mapoma, Joemer C. Maravilla, Ashley Marks, Randall V. Martin, Santi Martini, Francisco Rogerlandio Martins-Melo, Ira Martopullo, Anthony Masaka, Seyedeh Zahra Masoumi, Joao Massano, Benjamin Ballard Massenburg, Claudia I. Mastrogiacomo, Manu Raj Mathur, Kunihiro Matsushita, Pallab K. Maulik, Erin A. May, Mohsen Mazidi, Colm McAlinden, John J. McGrath, Martin Mckee, Carlo Eduardo Medina-Solis, Birhanu Geta Meharie, Man Mohan Mehndiratta, Entezar Mehrabi Nasab, Fereshteh Mehri, Ravi Mehrotra, Kala M. Mehta, Wahengbam Bigyananda Meitei, Teferi Mekonnen, Addisu Melese, Peter T. N. Memiah, Ziad A. Memish, Walter Mendoza, Ritesh G. Menezes, Endalkachew Worku Mengesha, Meresa Berwo Mengesha, George A. Mensah, Alibek Mereke, Seid Tiku Mereta, Atte Meretoja, Tuomo J. Meretoja, Tomislav Mestrovic, Bartosz Miazgowski, Tomasz Miazgowski, Irmina Maria Michalek, Kebadnew Mulatu Mihretie, Ted R. Miller, Edward J. Mills, George J. Milne, G. K. Mini, Mohammad Miri, Andreea Mirica, Erkin M. Mirrakhimov, Hamed Mirzaei, Maryam Mirzaei, Roya Mirzaei, Mehdi Mirzaei-Alavijeh, Awoke Temesgen Misganaw, Philip B. Mitchell, Prasanna Mithra, Babak Moazen, Masoud Moghadaszadeh, Bahram Mohajer, Osama Mohamad, Efat Mohamadi, Dara K. Mohammad, Yousef Mohammad, Naser Mohammad Gholi Mezerji, Abolfazl Mohammadbeigi, Abdollah Mohammadian-Hafshejani, Noushin Mohammadifard, Reza Mohammadpourhodki, Ammas Siraj Mohammed, Hussen Mohammed, Jemal Abdu Mohammed, Shafiu Mohammed, Farnam Mohebi, Mohammad A. Mohseni Bandpei, Amin Mokari, Ali H. Mokdad, Mariam Molokhia, Natalie C. Momen, Lorenzo Monasta, Stefania Mondello, Meghan D. Mooney, Mahmood Moosazadeh, Ghobad Moradi, Masoud Moradi, Mohammad Moradi-Joo, Maziar Moradi-Lakeh, Rahmatollah Moradzadeh, Paula Moraga, Linda Morales, Lidia Morawska, Ilais Moreno Velasquez, Joana Morgado-da-Costa, Shane Douglas Morrison, Abbas Mosapour, Jonathan F. Mosser, Simin Mouodi, Seyyed Meysam Mousavi, Amin Mousavi Khaneghah, Ulrich Otto Mueller, Satinath Mukhopadhyay, Erin C. Mullany, John Everett Mumford, Sandra B. Munro, Moses K. Muriithi, Kamarul Imran Musa, Ghulam Mustafa, Saravanan Muthupandian, Behnam Nabavizadeh, Ashraf F. Nabhan, Mehdi Naderi, Ahamarshan Jayaraman Nagarajan, Gabriele Nagel, Mohsen Naghavi, Behshad Naghshtabrizi, Gurudatta Naik, Mukhammad David Naimzada, Sanjeev Nair, Farid Najafi, Luigi Naldi, Vishnu Nandakumar, Anita K. Nandi, Vinay Nangia, Jobert Richie Nansseu, Morteza Naserbakht, Vinod C. Nayak, Javad Nazari, Rawlance Ndejjo, Duduzile Edith Ndwandwe, Ionut Negoi, Ruxandra Irina Negoi, Henok Biresaw Netsere, Subas Neupane, Kiirithio N. Ngari, Georges Nguefack-Tsague, Josephine W. Ngunjiri, Cuong Tat Nguyen, Diep Ngoc Nguyen, Huong Lan Thi Nguyen, Jason Nguyen, Michele Nguyen, Ming Nguyen, Trang Huyen Nguyen, Emma Nichols, Dabere Nigatu, Yeshambel T. Nigatu, Rajan Nikbakhsh, Amin Reza Nikpoor, Molly R. Nixon, Chukwudi A. Nnaji, Shuhei Nomura, Ole F. Norheim, Bo Norrving, Jean Jacques Noubiap, Soraya Nouraei Motlagh, Christoph Nowak, Elaine Okanyene Nsoesie, Virginia Nunez-Samudio, Bogdan Oancea, Christopher M. Odell, Felix Akpojene Ogbo, Onome Bright Oghenetega, In-Hwan Oh, Emmanuel Wandera Okunga, Morteza Oladnabi, Andrew T. Olagunju, Bolajoko Olubukunola Olusanya, Jacob Olusegun Olusanya, Mojisola Morenike Oluwasanu, Ahmed Omar Bali, Muktar Omer Omer, Kanyin L. Ong, Sokking Ong, Obinna E. Onwujekwe, Eyal Oren, Aislyn U. Orji, Heather M. Orpana, Doris V. Ortega-Altamirano, Alberto Ortiz, Osayomwanbo Osarenotor, Frank B. Osei, Sergej M. Ostojic, Samuel M. Ostroff, Adrian O. Oiu, Nikita Otstavnov, Stanislav S. Otstavnov, Simon Overland, Mayowa O. Owolabi, Mahesh P. A. Section, Jagadish Rao Padubidri, Smita Pakhale, Abhijit P. Pakhare, Keyvan Pakshir, Raffaele Palladino, Adrian Pana, Songhomitra Panda-Jonas, Anamika Pandey, Helena Ullyartha Pangaribuan, Eun-Kee Park, James Park, Priya G. Kumari Parmar, Charles D. H. Parry, Maja Pasovic, Deepak Kumar Pasupula, Jenil R. Patel, Sangram Kishor Patel, Angel J. Paternina-Caicedo, Ashish Pathak, Mona Pathak, Scott B. Patten, George C. Patton, Deepak Paudel, Sagun Paudel, Katherine R. Paulson, Hamidreza Pazoki Toroudi, Spencer A. Pease, Amy E. Peden, Alyssa Pennini, Veincent Christian Filipino Pepito, Emmanuel K. Peprah, Alexandre Pereira, David M. Pereira, Jeevan Pereira, Norberto Perico, Julia Moreira Pescarini, Konrad Pesudovs, Hai Quang Pham, Michael R. Phillips, Cristiano Piccinelli, Maxwell Pierce, David M. Pigott, Thomas Pilgrim, Tessa M. Pilz, Marina Pinheiro, Michael A. Piradov, Meghdad Pirsaheb, Farhad Pishgar, Oleguer Plana-Ripoll, Dietrich Plass, Martin Pletcher, Khem Narayan Pokhrel, Roman V. Polibin, Suzanne Polinder, Kevan R. Polkinghorne, Constance Dimity Pond, Maarten J. Postma, Faheem Hyder Pottoo, Hadi Pourjafar, Farshad Pourmalek, Reza Pourmirza Kalhori, Akram Pourshams, Anna Poznanska, Sergio I. Prada, Sanjay Prakash, V. Prakash, Narayan Prasad, Liliana Preotescu, Dimas Ria Angga Pribadi, Elisabetta Pupillo, Zahiruddin Quazi Syed, Mohammad Rabiee, Navid Rabiee, Amir Radfar, Ata Rafiee, Alireza Rafiei, Alberto Raggi, Fakher Rahim, Afarin Rahimi-Movaghar, Mohammad Hifz Ur Rahman, Muhammad Aziz Rahman, Ali Rajabpour-Sanati, Fatemeh Rajati, Ivo Rakovac, Pradhum Ram, Kiana Ramezanzadeh, Saleem Muhammad Rana, Chhabi Lal Ranabhat, Annemarei Ranta, Puja C. Rao, Sowmya J. Rao, Davide Rasella, Vahid Rashedi, Prateek Rastogi, Goura Kishor Rath, Priya Rathi, David Laith Rawaf, Salman Rawaf, Lal Rawal, Reza Rawassizadeh, Ramu Rawat, Christian Razo, Sofia Boston, Lemma Demissie Regassa, Robert C. Reiner, Nickolas Reinig, Marissa Bettay Reitsma, Giuseppe Remuzzi, Vishnu Renjith, Andre M. N. Renzaho, Serge Resnikoff, Negar Rezaei, Nima Rezaei, Mohammad Sadegh Rezai, Aziz Rezapour, Phoebe-Anne Rhinehart, Seyed Mohammad Riahi, Antonio Luiz P. Ribeiro, Daniel Cury Ribeiro, Daniela Ribeiro, Jennifer Rickard, Juan A. Rivera, Toshana Robalik, Nicholas L. S. Roberts, Shaun Roberts, Stephen R. Robinson, Sonia Rodriguez-Ramirez, Leonardo Roever, Sam Rolfe, Michele Romoli, Luca Ronfani, Robin Room, Gholamreza Roshandel, Morteza Rostamian, Gregory A. Roth, Dietrich Rothenbacher, Enrico Rubagotti, Susan Fred Rumisha, Godfrey M. Rwegerera, Seyedmohammad Saadatagah, Siamak Sabour, Perminder S. Sachdev, Basema Saddik, Ehsan Sadeghi, Masoumeh Sadeghi, Reza Saeedi, Sahar Saeedi Moghaddam, Shahram Saeidi, Yahya Safari, Sare Safi, Saeid Safiri, Rajesh Sagar, Amirhossein Sahebkar, Mohammad Ali Sahraian, S. Mohammad Sajadi, Mohammad Reza Salahshoor, Nasir Salam, Joseph S. Salama, Payman Salamati, Saleh Salehi Zahabi, Hosni Salem, Marwa R. Salem, Yahya Salimi, Hamideh Salimzadeh, Omar Mukhtar Salman, Joshua A. Salomon, Inbal Salz, Zainab Samad, Hossein Samadi Kafil, Evanson Zondani Sambala, Abdallah M. Samy, Juan Sanabria, Tania G. Sanchez-Pimienta, Damian Francesco Santomauro, Itamar S. Santos, Joao Vasco Santos, Milena M. Santric-Milicevic, Sivan Yegnanarayana Iyer Saraswathy, Rodrigo Sarmiento-Suarez, Nizal Sarrafzadegan, Benn Sartorius, Arash Sarveazad, Brijesh Sathian, Thirunavukkarasu Sathish, Davide Sattin, Miloje Savic, Susan M. Sawyer, Deepak Saxena, Sonia Saxena, Mete Saylan, Alyssa N. Sbarra, Lauren E. Schaeffer, Silvia Schiavolin, Markus P. Schlaich, Maria Ines Schmidt, Aletta Elisabeth Schutte, David C. Schwebel, Falk Schwendicke, Soraya Seedat, Mario Sekerija, Anbissa Muleta Senbeta, Subramanian Senthilkumaran, Sadaf G. Sepanlou, Berrin Serdar, Marc L. Serre, Edson Servan-Mori, Feng Sha, Mahsima Shabani, Katya Anne Shackelford, Jamileh Shadid, Omid Shafaat, Saeed Shahabi, Mohammad Shahbaz, Amira A. Shaheen, Masood Ali Shaikh, Ali S. Shalash, Mehran Shams-Beyranvand, MohammadBagher Shamsi, Morteza Shamsizadeh, Mohammed Shannawaz, Kiomars Sharafi, Zeinab Sharafi, Fablina Sharara, Hamid Sharifi, Rajesh Sharma, David H. Shaw, Brittney S. Sheena, Aziz Sheikh, Abbas Sheikhtaheri, B. Suresh Kumar Shetty, Ranjitha S. Shetty, Kenji Shibuya, Kevin David Shield, Wondimeneh Shibabaw Shiferaw, Mika Shigematsu, Jae Il Shin, Min-Jeong Shin, Rahman Shiri, Reza Shirkoohi, K. M. Shivakumar, Mark G. Shrime, Kerem Shuval, Soraya Siabani, Radoslaw Sierpinski, Inga Dora Sigfusdottir, Rannveig Sigurvinsdottir, Diego Augusto Santos Silva, Joao Pedro Silva, Biagio Simonetti, Kyle E. Simpson, Ambrish Singh, Jasvinder A. Singh, Pushpendra Singh, Dhirendra Narain Sinha, Eirini Skiadaresi, Soren T. Skou, Valentin Yurievich Skryabin, Karen Sliwa, Amanda Smith, Emma U. R. Smith, Eugene Sobngwi, Amin Soheili, Anton Sokhan, Shahin Soltani, Oluwaseyi Dolapo Somefun, Moslem Soofi, Reed J. D. Sorensen, Joan B. Soriano, Muluken Bekele Sorrie, Sergey Soshnikov, Ireneous N. Soyiri, Cory N. Spencer, Adel Spotin, Emma Elizabeth Spurlock, Chandrashekhar T. Sreeramareddy, Vinay Srinivasan, Kam Sripada, Jeffrey D. Stanaway, Benjamin A. Stark, Nicholas Steel, Simona Catalina Stefan, Caroline Stein, Dan J. Stein, Caitlyn Steiner, Timothy J. Steiner, Krista M. Steuben, Leo Stockfelt, Mark A. Stokes, Lars Jacob Stovner, Kurt Straif, Saverio Stranges, Jacob L. Stubbs, Parminder S. Suchdev, Agus Sudaryanto, Mu'awiyyah Babale Sufiyan, Hafiz Ansar Rasul Suleria, Rizwan Suliankatchi Abdulkader, Gerhard Sulo, Iyad Sultan, Carolyn B. Swope, Bryan L. Sykes, Dillon O. Sylte, Miklos Szocska, Lukasz Szumowski, Rafael Tabares-Seisdedos, Karen M. Tabb, Takahiro Tabuchi, Santosh Kumar Tadakamadla, Biruk Wogayehu Taddele, Degena Bahrey Tadesse, Amir Taherkhani, Zarfishan Tahir, Masih Tajdini, Ken Takahashi, Jukka S. Takala, Animut Tagele Tamiru, Muming Tang, Frank C. Tanser, Md Ismail Tareque, Ingan Ukur Tarigan, Nuno Taveira, Heather Jean Taylor, Whitney L. Teagle, Hirut Teame, Fabrizio Tediosi, Yonas Getaye Tefera, Arash Tehrani-Banihashemi, Berhane Fseha Teklehaimanot, Freweini Gebrearegay Tela, Mohamad-Hani Temsah, Sonyah Terrason, Getayeneh Antehunegn Tesema, Zemenu Tadesse Tessema, Bhaskar Thakur, Kavumpurathu Raman Thankappan, Rekha Thapar, Nihal Thomas, Azalea M. Thomson, Amanda G. Thrift, George D. Thurston, Mariya Vladimirovna Titova, Boikhutso Tlou, Hamid Reza Tohidinik, Marcello Tonelli, Roman Topor-Madry, Fotis Topouzis, Anna E. Torre, Mathilde Touvier, Marcos Roberto Tovani-Palone, Eugenio Traini, Bach Xuan Tran, Ravensara Travillian, Sergi Trias-Llimos, Christopher E. Troeger, Thomas Clement Truelsen, Alexander C. Tsai, Aristidis Tsatsakis, Lorainne Tudor Car, Stefanos Tyrovolas, Riaz Uddin, Irfan Ullah, Saif Ullah, Chukwuma David Umeokonkwo, Eduardo A. Undurraga, Bhaskaran Unnikrishnan, Era Upadhyay, Olalekan A. Uthman, Marco Vacante, Regina Vaicekonyte, Alireza Vakilian, Pascual R. Valdez, Alessandro Valli, Aaron Van Donkelaar, Constantine Vardavas, Santosh Varughese, Tommi Juhani Vasankari, Ana Maria Nogales Vasconcelos, Yasser Vasseghian, Yousef Veisani, Narayanaswamy Venketasubramanian, Simone Vidale, Francesco S. Violante, Vasily Vlassov, Stein Emil Vollset, Avina Vongpradith, Theo Vos, Giang Thu Vu, Isidora S. Vujcic, Ana Vukovic, Rade Vukovic, Feleke Gebremeskel W. Hawariat, Yasir Waheed, Mitchell Taylor Wallin, Magdalene K. Walters, Richard G. Wamai, Fang Wang, Haidong Wang, Hongbo Wang, Jiayu Wang, Yafeng Wang, Yanzhong Wang, Yuan-Pang Wang, Joseph L. Ward, Alexandrea Watson, Stefanie Watson, Jingkai Wei, Melissa Y. Wei Wei, Robert G. Weintraub, Daniel J. Weiss, Jordan Weiss, Fissaha Tekulu Welay, Girmay Teklay Weldesamuel, Andrea Werdecker, J. Jason West, Ronny Westerman, Joanna L. Whisnant, Harvey A. Whiteford, Taweewat Wiangkham, Nuwan Darshana Wickramasinghe, Kirsten E. Wiens, Tissa Wijeratne, Lauren B. Wilner, Shadrach Wilson, Charles Shey Wiysonge, Bogdan Wojtyniak, Gebremariam Woldu, Charles D. A. Wolfe, Temesgen Gebeyehu Wondmeneh, Adam Belay Wondmieneh, Eve E. Wool, Sarah S. Wozniak, Ai-Min Wu, Chenkai Wu, Junjie Wu, Sarah Wulf Hanson, Han Yong Wunrow, Yang Xie, Gelin Xu, Rixing Xu, Simon Yadgir, Seyed Hossein Yahyazadeh Jabbari, Tomohide Yamada, Kazumasa Yamagishi, Mousa Yaminfirooz, Yuichiro Yano, Sanni Yaya, Vahid Yazdi-Feyzabadi, Jamal A. Yearwood, Tomas Y. Yeheyis, Yordanos Gizachew Yeshitila, Christopher Sabo Yilgwan, Mekdes Tigistu Yilma, Paul Yip, Naohiro Yonemoto, Seok-Jun Yoon, Javad Yoosefi Lebni, Hunter W. York, Mustafa Z. Younis, Theodore Patrick Younker, Bahman Yousefi, Zabihollah Yousefi, Mahmoud Yousefifard, Taraneh Yousefinezhadi, Abdilahi Yousuf Yousuf, Chuanhua Yu, Yong Yu, Chun-Wei Yuan, Deniz Yuce, Hasan Yusefzadeh, Siddhesh Zadey, Telma Zahirian Moghadam, Syed Saoud Zaidi, Leila Zaki, Josefina Zakzuk, Sojib Bin Zaman, Mohammad Zamani, Maryam Zamanian, Hamed Zandian, Alireza Zangeneh, Hadi Zarafshan, Mikhail Sergeevich Zastrozhin, Kaleab Alemayehu Zewdie, Jianrong Zhang, Yunquan Zhang, Zhi-Jiang Zhang, Jeff T. Zhao, Xiu-Ju George Zhao, Yingxi Zhao, Bistra Zheleva, Peng Zheng, Maigeng Zhou, Cong Zhu, Arash Ziapour, Stephanie R. M. Zimsen, Bianca S. Zlavog, Sanjay Zodpey, Stephen S. Lim, Christopher J. L. Murray

  LANCET 396 10258 1135 - 1159 2020年10月 [査読有り]
   

  The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 provides a rules-based synthesis of the available evidence on levels and trends in health outcomes, a diverse set of risk factors, and health system responses. GBD 2019 covered 204 countries and territories, as well as first administrative level disaggregations for 22 countries, from 1990 to 2019. Because GBD is highly standardised and comprehensive, spanning both fatal and non-fatal outcomes, and uses a mutually exclusive and collectively exhaustive list of hierarchical disease and injury causes, the study provides a powerful basis for detailed and broad insights on global health trends and emerging challenges. GBD 2019 incorporates data from 281 586 sources and provides more than 3.5 billion estimates of health outcome and health system measures of interest for global, national, and subnational policy dialogue. All GBD estimates are publicly available and adhere to the Guidelines on Accurate and Transparent Health Estimate Reporting. From this vast amount of information, five key insights that are important for health, social, and economic development strategies have been distilled. These insights are subject to the many limitations outlined in each of the component GBD capstone papers.
• Global burden of 87 risk factors in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019

  GBD Risk Factors Collaborators including Houman Goudarzi

  Lancet 396 10258 1223 - 1249 2020年10月 [査読有り]
  
• Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019

  GBD Diseases, Injuries Collaborators including Houman Goudarzi

  Lancet 396 10258 1204 - 1222 2020年10月 [査読有り]
  
• Effect of prenatal exposure to per- and polyfluoroalkyl substances on childhood allergies and common infectious diseases in children up to age 7 years: The Hokkaido study on environment and children's health

  Yu Ait Bamai, Houman Goudarzi, Atsuko Araki, Emiko Okada, Ikuko Kashino, Chihiro Miyashita, Reiko Kishi

  Environment International 143:105979 105979 - 105979 2020年10月 [査読有り]
   

  Per- and polyfluoroalkyl substances (PFAS) are widely used bio-accumulative chemicals in many industrial and household products. Experimental studies reported that exposure to PFAS results in immunotoxicity. We have previously reported that prenatal exposure to PFAS decreased the risk of allergies, while it increased the risk of infectious diseases at ages 2 and 4 years. However, it remains unclear whether the adverse effects of PFAS on allergies and infectious diseases continue until a reliable age of diagnosing allergies. This study aimed at investigating the effects of prenatal exposure to PFAS on the prevalence of allergies and infectious diseases in children up to age 7, from the Hokkaido Study. Among mother-child pairs enrolled in the Hokkaido study and followed up until the age of 7 years, 2689 participants with maternal PFAS, 1st trimester of pregnancy and 7-year-old questionnaire survey data were included in this study. Eleven PFAS in the 3rd-trimester plasma were measured using ultra-performance liquid chromatography coupled to triple quadrupole tandem mass spectrometry. Wheeze, rhino-conjunctivitis, and eczema were defined using the International Study of Asthma and Allergies on Childhood (ISAAC) questionnaire. History childhood infectious diseases diagnosed by a doctor was assessed by a mother-reported questionnaire at child's age 7. The relative risk of childhood allergies was calculated by generalized estimating equation models. The odds ratio of an episode of infectious diseases was calculated by logistic regression analysis, adjusted for potential confounders. The prevalence of various allergies and infectious diseases was: wheeze, 11.9%; rhino-conjunctivitis, 11.3%; eczema, 21.0%; chickenpox, 61.5%; otitis media, 55.7%; pneumonia, 30.6%; and respiratory syncytial virus infection, 16.8%. Prenatal exposure to perfluorooctanoic acid, perfluorodecanoic acid (PFDA), and perfluoroundecanoic acid (PFUnDA) was inversely associated with rhino-conjunctivitis, while that for perfluorooctanoate (PFOA), perfluorooctane sulfonate, PFUnDA, perfluorododecanoic acid (PFDoDA), and perfluorotridecanoic acid was inversely associated with eczema. For infectious diseases, PFDA and PFDoDA were associated with increased risk of pneumonia and PFOA was associated with increased risk of RSV infection among children not having any siblings (only-one-child). Our results corroborate the hypothesis on immunosuppressive and immunomodulating effects of PFAS on allergies and infectious diseases in children. These effects observed previously at 2 and 4 years continued until the age of 7 years. However, additional studies assessing inflammatory biomarkers along with ISAAC questionnaires, doctor-diagnosed allergies, and longer follow-ups are necessary to better assess the effects of exposure to chemicals on human immune outcomes.
• 重症喘息患者における呼吸機能の経年変化とその関連因子について

  木村 孔一, 牧田 比呂仁, 谷口 菜津子, 木村 裕樹, 清水 薫子, 鈴木 雅, 武井 望, 松本 宗大, Goudarzi Houman, 西村 正治, 今野 哲

  日本呼吸器学会誌 9 増刊 223 - 223 (一社)日本呼吸器学会 2020年08月
• Temporal trends and determinants of PFR exposure in the Hokkaido Study.

  Michiel Bastiaensen, Yu Ait Bamai, Atsuko Araki, Houman Goudarzi, Satoshi Konno, Sachiko Ito, Chihiro Miyashita, Yiming Yao, Reiko Kishi, Adrian Covaci

  International journal of hygiene and environmental health 228 113523 - 113523 2020年07月 [査読有り][通常論文]
   

  The phase-out of polybrominated diphenyl ethers (PBDE) flame retardants has led to the rapid increase of alternatives such as phosphate flame retardants and plasticizers (PFRs) in many consumer products. Exposure to these additive chemicals is widespread and potentially harmful to humans and the environment. In the present study, we assessed the exposure to PFRs through the analysis of metabolites in urine collected from 7-year old children from Hokkaido, Japan between 2012 and 2017. This allowed us to investigate temporal and seasonal trends for PFR metabolite concentrations and to study determinants of exposure. Thirteen metabolites of seven PFRs were measured in morning spot urine samples (n = 400). Multiple regression models were used to quantify the yearly increase in metabolite concentrations per sampling year. Information on the demographics, indoor environment and dietary habits of the participants were derived from self-administered questionnaires. PFR metabolite concentrations were comparable to our previous study of school children (7-12 years old). Eight PFR metabolites were detected in >50% of the samples. During the study time period, concentrations of three metabolites increased significantly: bis(1,3-dichloro-2-propyl) phosphate (BDCIPP; 13.3% per year), 1-hydroxy-2-propyl bis(1-chloro-2-propyl) phosphate (BCIPHIPP; 12.9% per year), and 2-ethylhexyl phenyl phosphate (EHPHP; 6.7% per year). We also found seasonality as a determinant for several PFR metabolites, with 2-fold higher levels in summer for BCIPHIPP and BDCIPP. Concentrations were also significantly impacted by ventilation habits. More frequent window opening or use of mechanical ventilation was consistently associated with higher levels of PFR metabolites in children's urine. This is the first study to show that human exposure to PFRs has increased in recent years in Japan, which indicates that further research into this class of chemicals is warranted.
• Prevalence and attributable health burden of chronic respiratory diseases, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017

  GBD Chronic Respiratory Disease Collaborators including Houman Goudarzi

  Lancet Respiratory Medicine 8 6 585 - 596 2020年06月 [査読有り]
   

  © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Background: Previous attempts to characterise the burden of chronic respiratory diseases have focused only on specific disease conditions, such as chronic obstructive pulmonary disease (COPD) or asthma. In this study, we aimed to characterise the burden of chronic respiratory diseases globally, providing a comprehensive and up-to-date analysis on geographical and time trends from 1990 to 2017. Methods: Using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017, we estimated the prevalence, morbidity, and mortality attributable to chronic respiratory diseases through an analysis of deaths, disability-adjusted life-years (DALYs), and years of life lost (YLL) by GBD super-region, from 1990 to 2017, stratified by age and sex. Specific diseases analysed included asthma, COPD, interstitial lung disease and pulmonary sarcoidosis, pneumoconiosis, and other chronic respiratory diseases. We also assessed the contribution of risk factors (smoking, second-hand smoke, ambient particulate matter and ozone pollution, household air pollution from solid fuels, and occupational risks) to chronic respiratory disease-attributable DALYs. Findings: In 2017, 544·9 million people (95% uncertainty interval [UI] 506·9–584·8) worldwide had a chronic respiratory disease, representing an increase of 39·8% compared with 1990. Chronic respiratory disease prevalence showed wide variability across GBD super-regions, with the highest prevalence among both males and females in high-income regions, and the lowest prevalence in sub-Saharan Africa and south Asia. The age-sex-specific prevalence of each chronic respiratory disease in 2017 was also highly variable geographically. Chronic respiratory diseases were the third leading cause of death in 2017 (7·0% [95% UI 6·8–7·2] of all deaths), behind cardiovascular diseases and neoplasms. Deaths due to chronic respiratory diseases numbered 3 914 196 (95% UI 3 790 578–4 044 819) in 2017, an increase of 18·0% since 1990, while total DALYs increased by 13·3%. However, when accounting for ageing and population growth, declines were observed in age-standardised prevalence (14·3% decrease), age-standardised death rates (42·6%), and age-standardised DALY rates (38·2%). In males and females, most chronic respiratory disease-attributable deaths and DALYs were due to COPD. In regional analyses, mortality rates from chronic respiratory diseases were greatest in south Asia and lowest in sub-Saharan Africa, also across both sexes. Notably, although absolute prevalence was lower in south Asia than in most other super-regions, YLLs due to chronic respiratory diseases across the subcontinent were the highest in the world. Death rates due to interstitial lung disease and pulmonary sarcoidosis were greater than those due to pneumoconiosis in all super-regions. Smoking was the leading risk factor for chronic respiratory disease-related disability across all regions for men. Among women, household air pollution from solid fuels was the predominant risk factor for chronic respiratory diseases in south Asia and sub-Saharan Africa, while ambient particulate matter represented the leading risk factor in southeast Asia, east Asia, and Oceania, and in the Middle East and north Africa super-region. Interpretation: Our study shows that chronic respiratory diseases remain a leading cause of death and disability worldwide, with growth in absolute numbers but sharp declines in several age-standardised estimators since 1990. Premature mortality from chronic respiratory diseases seems to be highest in regions with less-resourced health systems on a per-capita basis. Funding: Bill & Melinda Gates Foundation.
• Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

  LBD Double, Burden of Malnutrition Collaborators including Houman Goudarzi

  Nature Medicine 26 5 750 - 775 2020年05月 [査読有り]
  
• Prenatal exposure to 11 perfluoroalkyl substances and fetal growth: A large-scale, prospective birth cohort study.

  Ikuko Kashino, Seiko Sasaki, Emiko Okada, Hideyuki Matsuura, Houman Goudarzi, Chihiro Miyashita, Eisaku Okada, Yoichi M Ito, Atsuko Araki, Reiko Kishi

  Environment International 136 105355 - 105355 2020年03月 [査読有り][通常論文]
   

  BACKGROUND: Prenatal maternal exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) has been reportedly associated with decreased birth weight. Although a majority of epidemiological studies concerning perfluoroalkyl substances (PFAS) have focused on PFOS and PFOA, epidemiological studies of PFAS with longer carbon chains are scarce. In this study, we investigated whether prenatal maternal exposure to 11 PFAS, in particular those with longer carbon chains, is associated with fetal growth. METHODS: The study included 1985 mother-infant pairs (inclusive of preterm and post-term infants), who enrolled in a large-scale, prospective birth cohort study in any of the 37 hospitals in Hokkaido, Japan between 2003 and 2009. The concentration of 11 PFAS was measured in maternal plasma collected during the third trimester of pregnancy, using ultra-performance liquid chromatography in combination with triple quadrupole mass spectrometry. Associations between the measured PFAS values and weight, length, and head circumference of all newborns at birth were examined using multiple regression analyses with adjustment for potential confounders based on data collected from medical records, questionnaires, and those for maternal plasma samples. RESULTS: Of the 11 PFAS analyzed, prenatal perfluorononanoic acid (PFNA) [per log10-unit: regression coefficient (β) = -96.2 g, 95% confidence intervals (95% CI), -165.3 to -27.1] and perfluorodecanoic acid (PFDA) (β = -72.2 g, 95% CI, -138.1 to -6.3) concentrations were inversely associated with birth weight. Furthermore, PFNA concentrations were inversely associated with birth length (per Log10 unit: β = -0.48 cm, 95% CI; - 0.86 to -0.11). Maternal perfluorotridecanoic acid (PFTrDA) exposure showed a significant inverse association with birth weight only for female infants (per Log10 unit: β = -99.8 g, 95% CI, - 193.7 to -6.0) (P for interaction = 0.04). CONCLUSIONS: Our findings suggest that prenatal, maternal exposure to PFAS with longer carbon chains tends to be inversely associated with birth size of newborn infants, which may indicate that these commercially used compounds have an adverse effect on fetal growth.
• Combined exposure to phthalate esters and phosphate flame retardants and plasticizers and their associations with wheeze and allergy symptoms among school children.

  Atsuko Araki, Yu Ait Bamai, Michiel Bastiaensen, Nele Van den Eede, Toshio Kawai, Tazuru Tsuboi, Chihiro Miyashita, Sachiko Itoh, Houman Goudarzi, Satoshi Konno, Adrian Covaci, Reiko Kishi

  Environmental research 183 109212 - 109212 2020年02月03日 [査読有り][通常論文]
   

  BACKGROUND: Phthalate esters and phosphate flame retardants and plasticizers (PFRs) are both used as plasticizers and are commonly detected in indoor environments. Although both phthalates and PFRs are known to be associated with children's wheeze and allergic symptoms, there have been no previous studies examining the effects of mixtures of these exposures. OBJECTIVES: To investigate the association between exposure to mixtures of phthalate esters and PFRs, and wheeze and allergic symptoms among school-aged children. METHODS: A total of 128 elementary school-aged children were enrolled. Metabolites of 3 phthalate esters and 7 PFRs were measured in urine samples. Parent-reported symptoms of wheeze, rhinoconjunctivitis, and eczema were evaluated using the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. In the primary model, we created a phthalate ester and PFR mixture exposure index, and estimated odds ratios (ORs) using weighted quantile sum (WQS) regression and quantile g (qg)-computation. The two highest chemicals according to qg-computation weight %s were combined to create a combination high × high exposure estimate, with ORs calculated using the "low × low" exposure group as the reference category. Concentrations of each metabolite were corrected by multiplying this value by the sex- and body size-Standardised creatinine concentration and dividing by the observed creatinine value. All models were adjusted for sex, grade, dampness index and annual house income. RESULTS: The odds ratio of rhinoconjunctivitis for the association between exposure to chemical mixtures according to the WQS index positive models was; OR = 2.60 (95% confidence interval [CI]: 1.38-5.14). However, wheeze and eczema of the WQS index positive model, none of the WQS index negative models or qg-computation result yielded statistically significant results. Combined exposure to the two highest WQS weight %s of "high-high" ΣTCIPP and ΣTPHP was associated with an increased prevalence of rhino-conjunctivitis, OR = 5.78 (1.81-18.43) to the "low × low" group. CONCLUSIONS: Significant associations of mixed exposures to phthalates and PFRs and increased prevalence of rhinoconjunctivitis was found among elementary school-aged children in the WQS positive model. Mixed exposures were not associated with any of allergic symptoms in the WQS negative model or qg-computation approach. However, the combined effects of exposure to two PFRs suggested an additive and/or multiplicative interaction, potentially increasing the prevalence of rhinoconjunctivitis. A further study with a larger sample size is needed to confirm these results.
• Association between perfluoroalkyl substance exposure and thyroid hormone/thyroid antibody levels in maternal and cord blood: The Hokkaido Study.

  Sachiko Itoh, Atsuko Araki, Chihiro Miyashita, Keiko Yamazaki, Houman Goudarzi, Machiko Minatoya, Yu Ait Bamai, Sumitaka Kobayashi, Emiko Okada, Ikuko Kashino, Motoyuki Yuasa, Toshiaki Baba, Reiko Kishi

  Environment international 133 Pt A 105139 - 105139 2019年12月 [査読有り][通常論文]
   

  BACKGROUND: Thyroid antibodies (TAs) are the most common cause of hypothyroidism during gestation. Although previous studies found that prenatal exposure to perfluoroalkyl substances (PFASs) disrupts thyroid hormones (THs) in humans, their effects on TAs during the perinatal period have not been investigated. OBJECTIVE: To explore the associations between prenatal exposure to eleven different PFASs from two different groups (carboxylates and sulfonates) and the expression of THs and TAs in maternal and cord blood while considering maternal TA status. METHODS: In a prospective birth cohort (the Hokkaido Study), we included 701 mother‑neonate pairs recruited in 2002-2005 for whom both prenatal maternal and cord blood samples were available. Eleven PFASs were measured in maternal plasma obtained at 28-32 weeks of gestation using ultra-performance liquid chromatography coupled with triple quadrupole tandem mass spectrometry. THs and TAs including thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), thyroid peroxidase antibody (TPOAb), and thyroglobulin antibody (TgAb) were measured in maternal blood during early pregnancy (median 11 gestational weeks), and in cord blood at birth. RESULTS: The median levels of TgAb and TPOAb in maternal serum were 15.0 and 6.0 IU/mL, respectively. The median TgAb level in neonates was 38.0 IU/mL, and TPOAb were detected in only 12.3% of samples. Maternal FT3 level was positively associated with PFAS levels in both TA-positive and TA-negative mothers. Maternal perfluorooctanoate was inversely associated with maternal TPOAb. Among boys, some maternal PFASs were associated with higher TSH and lower FT3 levels in maternal TA-negative group, while perfluorodecanoic acid was associated with lower TSH in maternal TA-positive group. Among girls, some PFAS of mothers showed associations with lower TSH and higher FT3 in maternal TA-negative group, while perfluorododecanoic acid was associated with lower FT4 in maternal TA-positive. Maternal PFASs showed associations with boy's TgAb inversely in maternal TA-negative group and with girl's TgAb positively in maternal TA-positive group. CONCLUSIONS: Our results suggest thyroid disrupting effects of PFAS exposure and susceptibility vary depending on maternal TA levels.
• Multiple exposures to organophosphate flame retardants alter urinary oxidative stress biomarkers among children: The Hokkaido Study.

  Yu Ait Bamai, Michiel Bastiaensen, Atsuko Araki, Houman Goudarzi, Satoshi Konno, Sachiko Ito, Chihiro Miyashita, Yiming Yao, Adrian Covaci, Reiko Kishi

  Environment international 131 105003 - 105003 2019年10月 [査読有り][通常論文]
   

  Organophosphate flame retardants (PFRs) are used as additives in plastics and other applications such as curtains and carpets as a replacement for brominated flame retardants. As such, exposure to PFR mixtures is widespread, with children being more vulnerable than adults to associated health risks such as allergies and inflammation. Oxidative stress is thought to be able to modulate the development of childhood airway inflammation and atopic dermatitis. To evaluate these associations, the present study investigated the relationship between urinary PFR metabolites, their mixtures and urinary oxidative stress biomarkers in children as part of the Hokkaido Study on Environment and Children's Health. The levels of the oxidative stress biomarkers, such as 8-hydroxy-2'-deoxyguanosine (8-OHdG), hexanoyl-lysine (HEL), and 4-hydroxynonenal (HNE), and of 14 PFR metabolites were measured in morning spot urine samples of 7-year-old children (n = 400). Associations between PFR metabolites or PFR metabolite mixtures and oxidative stress biomarkers were examined by multiple regression analysis and weighted quantile sum regression analysis, respectively. We found that the non-chlorinated PFR metabolites, 2-ethylhexyl phenyl phosphate (EHPHP), bis(2-butoxyethyl) phosphate (BBOEP), and diphenyl phosphate (DPHP) were associated with increased levels of oxidative stress biomarkers. Furthermore, the PFR metabolite mixture was associated with increased levels of HEL and HNE, but not 8-OHdG. The combination of elevated top 2 PFR metabolites was not associated with higher urinary oxidative stress marker levels. This is the first study to report associations between urinary PFR metabolites and oxidative stress biomarkers among children.
• 気道炎症・バイオマーカー 重症喘息患者における増悪状況とTh2マーカー陽性数の検討

  木村 孔一, 牧田 比呂仁, 谷口 菜津子, 木村 裕樹, 清水 薫子, 鈴木 雅, 武井 望, 松本 宗大, Goudarzi Houman, 西村 正治, 今野 哲

  アレルギー 68 4-5 491 - 491 (一社)日本アレルギー学会 2019年05月
• Impact of Abdominal Visceral Adiposity on Adult Asthma Symptoms.

  フーマン グーダルズィ

  J Allergy Clin Immunol Pract. 7(4):1222-1229.e5. 7 4 1222 - 1229 2019年04月 [査読有り][通常論文]
   

  BACKGROUND: Previous studies have shown the association of anthropometric measures with poor asthma symptoms, especially among women. However, the potential influence of visceral adiposity on asthma symptoms has not been investigated well. OBJECTIVE: In this study, we have evaluated whether visceral adiposity is related to poor adult asthma symptoms independent of anthropometric measures and sex. If this relationship presented, we investigated whether it is explained by influence on pulmonary functions and/or obesity-related comorbidities. METHODS: We analyzed data from 206 subjects with asthma from Japan. In addition to anthropometric measures (body mass index and waist circumference), abdominal visceral and subcutaneous fat were assessed by computed tomography scan. Quality of life was assessed using the Japanese version of the Asthma Quality of Life Questionnaire. RESULTS: All obesity indices had inverse association with reduced asthma quality of life among females. However, only the visceral fat area showed a statistical inverse association with Asthma Quality of Life Questionnaire in males. Only abdominal visceral fat was associated with higher gastroesophageal reflux disease and depression scores. Although all obesity indices showed inverse association with functional residual capacity, only visceral fat area had a significant inverse association with FEV1 % predicted, independent of other obesity indices. CONCLUSIONS: Regardless of sex, abdominal visceral fat was associated with reduced asthma quality of life independent of other obesity indices, and this may be explained by the impact of abdominal visceral fat on reduced FEV1 % predicted and higher risk for gastroesophageal reflux disease and depression. Therefore, visceral adiposity may have more clinical influence than any other obesity indices on asthma symptoms.
• 喘息患者における全身と痰の炎症バイオマーカーに対する肥満度指数の異なる影響(Differential impact of obesity indices on systemic and sputum inflammatory biomarkers among asthma patients)

  Goudarzi Houman, Konno Satoshi, Makita Hironi, Kimura Hirokazu, Matsumoto Munehiro, Takei Nozomu, Kimura Hiroki, Shimizu Kaoruko, Suzuki Masaru, Nishimura Masaharu

  日本呼吸器学会誌 8 増刊 365 - 365 2019年03月
• Contrasting associations of maternal smoking and pre-pregnancy BMI with wheeze and eczema in children

  Houman Goudarzi, Satoshi Konno, Hirokazu Kimura, Atsuko Araki, Chihiro Miyashita, Sachiko Itoh, Yu Ait Bamai, Hiroki Kimura, Kaoruko Shimizu, Masaru Suzuki, Yoichi M. Ito, Masaharu Nishimura, Reiko Kishi

  Science of the Total Environment 639 1601 - 1609 2018年10月15日 [査読有り][通常論文]
   

  Background: Childhood allergies are dynamic and associated with environmental factors. The influence of prenatal maternal smoking and obesity on childhood allergies and their comorbidities remains unclear, especially in prospective cohorts with serial longitudinal observations. Objective: We examined time trends in the prevalence and comorbidity of childhood allergies, including wheeze, eczema, and rhinoconjunctivitis, using a large-scale, population-based birth cohort in Japan, and assessed the effects of prenatal maternal smoking and BMI on the risk of childhood allergies. Methods: Parents completed the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaires about symptoms of allergies and their risk factors at age 1, 2, 4, and 7 years. Complete data from all pre- and postnatal questionnaires at age 1, 2, 4, and 7 were available for 3296 mother–child pairs. Results: We observed significant overlap of childhood allergies at 1, 2, 4, and 7 years. Maternal serum cotinine during pregnancy was associated with increased risk of wheezing in the children at age 1, 2, and 4 but disappeared at age 7. In contrast, maternal cotinine levels were inversely associated with the prevalence of eczema in children at age 7. We additionally observed that maternal pre-pregnancy BMI, not children's BMI, had a positive association with wheeze and an inverse association with eczema in 7-year-old children, respectively. We did not find any association of examined maternal factors and rhinoconjunctivitis. Conclusions: We demonstrated contrasting association of prenatal maternal smoking and high BMI with postnatal wheeze and eczema. For precise assessment of allergy-associated risk factors, we need to contrast risk factors for different allergic diseases since focusing solely on one allergic disease may result in misleading information on the role of different risk factors.
• Sex-related differences in the associations between maternal dioxin-like compounds and reproductive and steroid hormones in cord blood: The Hokkaido study

  Chihiro Miyashita, Atsuko Araki, Takahiko Mitsui, Sachiko Itoh, Houman Goudarzi, Seiko Sasaki, Jumboku Kajiwara, Tsuguhide Hori, Kazutoshi Cho, Kimihiko Moriya, Nobuo Shinohara, Katsuya Nonomura, Reiko Kishi

  Environment International 117 175 - 185 2018年08月01日 [査読有り][通常論文]
   

  Background: Prenatal exposure to dioxin-like compounds (DLCs) irreversibly affects fetal reproductive and steroid hormone synthesis. Objective: This study aimed to assess the relationships between maternal DLCs and cord blood reproductive and steroid hormones. Methods: Participants in this study were pregnant women who enrolled in the Sapporo Cohort of the Hokkaido Study between 2002 and 2005. We quantified 29 DLCs during the 2nd and 3rd trimesters in maternal blood. Additionally, we measured the concentrations of progesterone, estradiol (E2), testosterone (T), androstenedione, dehydroepiandrosterone (DHEA), cortisol, cortisone, sex hormone-binding globulin (SHBG), luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin, inhibin B, and insulin-like factor-3 (INSL3) in cord blood samples. Results: Data from 183 mother-child pairs were analyzed. We observed sex-dependent associations of DLCs on T/E2 ratios, DHEA, cortisol, cortisone, adrenal androgen/glucocorticoid (AA/GC: sum of DHEA and androstenedione)/(sum of cortisol and cortisone) ratios and SHBG. An increase in maternal DLCs related to decreased T/E2 ratios and SHBG and inhibin B levels, and increased AA/GC ratios and FSH and DHEA levels in male cord blood samples. However, an increase in maternal mono-ortho polychlorinated biphenyls related to increased cortisol, cortisone, and SHBG levels, and decreased DHEA levels and AA/GC ratios in female cord blood samples. Conclusions: Prenatal exposure to DLCs alters steroidogenesis and suppresses the secretion of inhibin B in male cord blood. Relationships between maternal DLCs and cord blood hormones differ between boys and girls. Further studies are required to clarify whether the effects of in utero exposure to DLCs on adrenal hormones extend into infancy and puberty.
• Relationship between adrenal steroid hormones in cord blood and birth weight: The Sapporo Cohort, Hokkaido Study on Environment and Children's Health.

  Mitsui T, Araki A, Goudarzi H, Miyashita C, Ito S, Sasaki S, Kitta T, Moriya K, Cho K, Morioka K, Kishi R, Shinohara N, Takeda M, Nonomura K

  American journal of human biology : the official journal of the Human Biology Council 30 4 e23127  2018年07月 [査読有り][通常論文]
   

  OBJECTIVES: We investigated the relationship between steroid hormone levels in cord blood and birth weight. METHODS: Among 514 participants in a prospective birth cohort study in Sapporo, the following hormone levels were measured in 294 stored cord blood samples from 135 males and 159 females: androstenedione, dehydroepiandrosterone (DHEA), cortisol, and cortisone. Birth weight information was obtained from medical records. RESULTS: Androstenedione/DHEA was significantly higher in males than in females, while DHEA was significantly higher in females. Birth weight was significantly higher in males than in females. Regarding cortisone, androstenedione/DHEA, and cortisone/cortisol, a correlation was observed with birth weight in males but not in females. CONCLUSIONS: Prenatal adrenal steroids as well as converting enzymes such as 11ß-hydrosteroid dehydrogenase type 2 and 3ß-hydrosteroid dehydrogenase may have an impact on prenatal physical development.
• Successful Application of Edoxaban in the Treatment of Venous Thromboembolism Recurrence in a Patient with Non-small Cell Lung Cancer after Tumor Shrinkage.

  Tetsuaki Shoji, Hidenori Mizugaki, Yasuyuki Ikezawa, Megumi Furuta, Yuta Takashima, Hajime Kikuchi, Houman Goudarzi, Hajime Asahina, Junko Kikuchi, Eiki Kikuchi, Jun Sakakibara-Konishi, Naofumi Shinagawa, Ichizo Tsujino, Masaharu Nishimura

  Internal medicine (Tokyo, Japan) 57 12 1769 - 1772 2018年06月15日 [査読有り][通常論文]
   

  This report describes the case of a 66-year-old man with non-small cell lung cancer and venous thromboembolism (VTE). Unfractionated heparin (UFH) was initially used to control VTE before chemotherapy. However, switching UFH to warfarin or edoxaban, a novel oral anticoagulant (NOAC), failed. Chemotherapy was then administered to control the tumor which was thought to have been the main cause of VTE, which had been treated by UFH. After tumor shrinkage was achieved by chemotherapy, we were able to successfully switch from UFH to edoxaban. Controlling the tumor size and activity enabled the use of edoxaban as maintenance therapy for VTE.
• Determinants and Temporal Trends of Perfluoroalkyl Substances in Pregnant Women: The Hokkaido Study on Environment and Children's Health.

  Meng-Shan Tsai, Chihiro Miyashita, Atsuko Araki, Sachiko Itoh, Yu Ait Bamai, Houman Goudarzi, Emiko Okada, Ikuko Kashino, Hideyuki Matsuura, Reiko Kishi

  International journal of environmental research and public health 15 5 2018年05月14日 [査読有り][通常論文]
   

  Perfluoroalkyl substances (PFAS) are persistent bio-accumulative chemicals that impact the health of pregnant women and their children. PFAS derive from environmental and consumer products, which depend on human lifestyle, socioeconomic characteristics, and time variation. Here, we aimed to explore the temporal trends of PFAS in pregnant women and the characteristics related to maternal PFAS concentration. Our study is part of the Hokkaido Study on Environment and Children's Health, the Hokkaido large-scale cohort that recruited pregnant women between 2003 and 2011. Blood samples were acquired from pregnant women during the third trimester to measure PFAS and cotinine concentrations. Maternal basic information was collected with a baseline structured questionnaire. Eleven PFAS were measured from 2123 samples with ultra-performance liquid chromatography coupled with triple quadrupole tandem mass spectrometry. Eight PFAS were above 80% detection rate and were included in the final analysis. We used multivariable linear regression to analyze the association of pregnant women characteristics with the levels of eight PFAS. The temporal trend of PFAS was observed in two periods (August 2003 to January 2006 and February 2006 to July 2012). The concentration of perfluorooctane sulfonate (PFOS) significantly decreased from August 2003 to January 2006 and from February 2006 to July 2012. The concentrations of perfluorododecanoic acid (PFDoDA), perfluoroundecanoic acid (PFUnDA), and perfluorotridecanoic acid (PFTrDA) increased significantly between August 2003 and January 2006, whereas they decreased significantly between February 2006 and July 2012. Women with pre-pregnancy body mass index (BMI) >25 kg/m² had lower PFUnDA, PFDoDA, and PFTrDA levels than did those with normal BMI (18.5⁻24.9 kg/m²). Pregnant women, who were active smokers (cotinine > 11.49 ng/mL), had higher PFOS than the non-smokers (cotinine < 0.22 ng/mL). Lower levels of PFHxS, PFOS, PFOA, PFNA, and PFDA were observed in women, who had given birth to more than one child. There were also significant positive associations between PFAS levels and annual income or maternal education. PFAS levels varied in women with higher pre-pregnancy BMI, active smoking status, higher education level and annual income. The causes of the individual PFAS differences should be explored in an independent study.
• Associations of Current Wheeze and Body Mass Index with Perennial and Seasonal Allergic Rhinitis in Young Adults

  Munehiro Matsumoto, Satoshi Konno, Hirokazu Kimura, Nozomu Takei, Hiroki Kimura, Kaoruko Shimizu, Houman Goudarzi, Masaru Suzuki, Satoshi Hashino, Masaharu Nishimura

  International Archives of Allergy and Immunology 176 2 143 - 149 2018年05月01日 [査読有り][通常論文]
   

  Background: The coexistence of asthma and allergic rhinitis (AR) and its distinct association with obesity have been reported. However, few studies have differentiated the two types of AR, i.e., perennial (PAR) and seasonal AR (SAR), with regard to their associations with asthma and obesity. The aim of this study was to evaluate the coexistence of current wheeze and two types of AR and the impact of body mass index (BMI) on these two conditions in Japanese young adults. Methods: First-year students from Hokkaido University were enrolled into this study from 2011 to 2016. A questionnaire survey including the prevalence of current wheeze, PAR, and SAR every year for 11,917 nonsmoking young adults was conducted. The difference in the impact of current wheeze and BMI on these two types of AR was separately evaluated. Results: Although both PAR and SAR were significantly associated with current wheeze, the impact of these two AR types on current wheeze was different (OR for PAR = 2.46 vs. OR for SAR = 1.29). When we classified all of the subjects into 4 groups with or/and without the two types of AR, the prevalence of current wheeze was significantly higher in subjects with PAR than in those without PAR (p < 0.001). However, the prevalence of current wheeze did not differ between subjects with or without SAR. Multinomial regression analyses showed that the association of wheeze with PAR and/or SAR was stronger compared to that of wheeze with SAR without PAR. The prevalence of PAR was not associated with BMI. Contrarily, a low BMI was significantly associated with a high SAR prevalence (p < 0.05). Conclusion: Comparisons between PAR and SAR showed that the conditions are differentially associated with current wheeze and BMI.
• 母親の喫煙およびBMIと小児の喘鳴および湿疹との対照的な関連性(Contrasting associations of maternal smoking and BMI with wheeze and eczema in children)

  Goudarzi Houman, Konno Satoshi, Kimura Hirokazu, Araki Atsuko, Miyashita Chihiro, Itou Sachiko, Bamai Yu Ait, Kimura Hiroki, Shimizu Kaoruko, Suzuki Masaru, Ito Yoichi, Nishimura Masaharu, Kishi Reiko

  アレルギー 67 4-5 509 - 509 2018年05月
• Prospective predictors of exacerbation status in severe asthma over a 3-year follow-up.

  Kimura H, Konno S, Makita H, Taniguchi N, Shimizu K, Suzuki M, Kimura H, Goudarzi H, Nakamaru Y, Ono J, Ohta S, Izuhara K, Ito YM, Wenzel SE, Nishimura M, Hi-CARAT investigators

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2018年05月 [査読有り][通常論文]
  
• Developmental Exposures to Perfluoroalkyl Substances (PFASs): An Update of Associated Health Outcomes.

  Liew Z, Goudarzi H, Oulhote Y

  Current environmental health reports 5 1 1 - 19 2018年03月 [査読有り][招待有り]
  
• Birth cohorts in Asia: The importance, advantages, and disadvantages of different-sized cohorts

  Reiko Kishi, Atsuko Araki, Machiko Minatoya, Sachiko Itoh, Houman Goudarzi, Chihiro Miyashita

  SCIENCE OF THE TOTAL ENVIRONMENT 615 1143 - 1154 2018年02月 [査読有り][通常論文]
   

  Asia contains half of the world's children, and the countries of Asia are the most rapidly industrializing nations on the globe. Environmental threats to the health of children in Asia are myriad. Several birth cohorts were started in Asia in early 2000, and currently more than 30 cohorts in 13 countries have been established for study. Cohorts can contain from approximately 100-200 to 20,000-30,000 participants. Furthermore, national cohorts targeting over 100,000 participants have been launched in Japan and Korea. The aim of this manuscript is to discuss the importance of Asian cohorts, and the advantages and disadvantages of different-sized cohorts. As for case, one small-sized (n = 514) cohort indicate that even relatively low level exposure to dioxin in utero could alter birth size, neurodevelopment, and immune and hormonal functions. Several Asian cohorts focus prenatal exposure to perfluoroalkyo substances and reported associations with birth size, thyroid hormone levels, allergies and neurodevelopment. Inconsistent findings may possibly be explained by the differences in exposure levels and target chemicals, and by possible statistical errors. In a smaller cohort, novel hypotheses or preliminary examinations are more easily verifiable. In larger cohorts, the etiology of rare diseases, such as birth defects, can be analyzed; however, they require a large cost and significant human resources. Therefore, conducting studies in only one large cohort may not always be the best strategy. International collaborations, such as the Birth Cohort Consortium of Asia, would cover the inherent limitation of sample size in addition to heterogeneity of exposure, ethnicity, and socioeconomic conditions. (C) 2017 Elsevier B.V. All rights reserved.
• Prenatal organochlorine pesticide exposure and the disruption of steroids and reproductive hormones in cord blood: The Hokkaido study

  Atsuko Araki, Chihiro Miyashita, Takahiko Mitsui, Houman Goudarzi, Futoshi Mizutani, Youichi Chisaki, Sachiko Itoh, Seiko Sasaki, Kazutoshi Cho, Kimihiko Moriya, Nobuo Shinohara, Katsuya Nonomura, Reiko Kishi

  ENVIRONMENT INTERNATIONAL 110 1 - 13 2018年01月 [査読有り][通常論文]
   

  Certain organochlorine pesticides (OCPs) are designated as persistent organic pollutants and are regulated in many countries. The effects of OCPs on pediatric endocrinology are a concern; however, only limited data exist from human studies on maternal OCP exposure and its effects on infants' hormone levels. This study was conducted as part of the Hokkaido Study Sapporo Cohort, a prospective birth cohort study in Japan. Participants included 514 women who enrolled at 23-35 weeks of gestation between 2002 and 2005; maternal blood samples were collected in late pregnancy, and 29 OCPs were measured. Reproductive and steroid hormone levels in cord blood were also determined. Characteristics of mothers and their infants were obtained from self-administered questionnaires and medical records. Ultimately, 232 samples with both OCP and hormone data were analyzed. Fifteen of 29 investigated OCPs were detected in over 80% of the samples, with p, p'-dichlorodiphenyldi-chloroethylene showing the highest concentration (median value: 619 pg/g-wet). The association between OCPs and sex hormone levels varied by sex. Linear regression models after sex stratification showed that chlordanes, cis-hexachlorobenzene, heptachlor epoxide, Mirex, and toxaphenes in maternal blood were inversely associated with testosterone, cortisol, cortisone, sex hormone-binding globin, prolactin, and androstenedione-dehydroepiandrosterone (DHEA) and testosterone-androstenediones ratios among boys. Furthermore, these OCPs were positively correlated with DHEA, follicle stimulating hormone (FSH), and adrenal androgen-glucocorticoid and FSH-inhibin B ratios among boys. In categorical quartile models, testosterone and DHEA were inversely and positively associated with OCPs, respectively. Estradiol-testosterone and adrenal androgen-glucocorticoid ratios tended to increase with increasing OCP concentrations in the higher quartile, while the testosterone-androstenedione ratio tended to decrease. Sex hormone-binding globulin and prolactin showed an inverse association with OCPs. Among girls, the linear regression model showed that only p, p'-dichlorodiphenyltrichloroethane was inversely associated with the level of DHEA and the adrenal androgen-glucocorticoid ratio, but was positively associated with cortisone levels. However, no associations were observed using the quartile categorical model. These results suggest that prenatal exposure to OCPs disrupt reproductive hormones of fetuses in utero among boys, even at relatively low levels.
• Serum periostin is associated with body mass index and allergic rhinitis in healthy and asthmatic subjects

  Hirokazu Kimura, Satoshi Konno, Hironi Makita, Natsuko Taniguchi, Hiroki Kimura, Houman Goudarzi, Kaoruko Shimizu, Masaru Suzuki, Noriharu Shijubo, Katsunori Shigehara, Junya Ono, Kenji Izuhara, Yoichi Minagawa Ito, Masaharu Nishimura

  Allergology International 67 3 357 - 363 2018年 [査読有り][通常論文]
   

  Background: Many studies have attempted to clarify the factors associated with serum periostin levels in asthmatic patients. However, these results were based on studies of subjects mainly characterized by high eosinophil counts, which may present as an obstacle for clarification in the identification of other factors associated with serum periostin levels. The aim of this study was to determine the factors associated with serum periostin levels in healthy subjects. We also assessed some factors in asthmatic subjects to confirm their extrapolation for management of asthma. Methods: Serum periostin levels were measured in 230 healthy subjects. Clinical factors of interest included body mass index (BMI) and allergic rhinitis (AR). Additionally, we confirmed whether these factors were associated with serum periostin in 206 asthmatic subjects. We further evaluated several obesity-related parameters, such as abdominal fat distribution and adipocytokine levels. Results: Smoking status, blood eosinophil count, total immunoglobulin E, and the presence of AR were associated with serum periostin in healthy subjects. There was a negative association between BMI and serum periostin in both healthy and asthmatic subjects, while there was a tendency of a positive association with AR in asthmatic subjects. There were no differential associations observed for subcutaneous and abdominal fat in relation to serum periostin in asthmatic subjects. Serum periostin was significantly associated with serum levels of adiponectin, but not with leptin. Conclusions: Our results provided clarity as to the factors associated with serum periostin levels, which could be helpful in the interpretation of serum periostin levels in clinical practice.
• Prevalence and risk of birth defects observed in a prospective cohort study: The Hokkaido study on environment and children’s health

  Tomoyuki Hanaoka, Naomi Tamura, Kumiko Ito, Seiko Sasaki, Atsuko Araki, Tamiko Ikeno, Chihiro Miyashita, Sachiko Ito, Hisanori Minakami, Kazutoshi Cho, Toshiaki Endo, Tsuyoshi Baba, Toshinobu Miyamoto, Kazuo Sengoku, Reiko Kishi, H. Goudarzi, M. Minatoya, S. Kobayashi, K. Yamazaki, S. Nishihara, Y. Ait Bamai, R. Miura, S. Kobayashi, A. Uno, S. Katoh, T. Baba, T. Yila, T. Braimoh, I. Kashino, S. Nakajima, T. Baba, Y. Saijyo, E. Yoshioka, T. Miyamoto, K. Okuyama, F. Sata, T. Kita

  Journal of Epidemiology 28 3 125 - 132 2018年 

  © 2017 Tomoyuki Hanaoka et al. Background: Prevalence rates of all anomalies classified as birth defects, including those identified before the 22nd gestational week, are limited in published reports, including those from the International Clearinghouse for Birth Defects Surveillance and Research (ICBDSR). In our birth cohort study, we collected the data for all birth defects after 12 weeks of gestation. Methods: Subjects in this study comprised 19,244 pregnant women who visited one of 37 associated hospitals in the Hokkaido Prefecture from 2003 through 2012, and completed follow-up. All birth defects after 12 weeks of gestation, including 55 marker anomalies associated with environmental chemical exposures, were recorded. We examined parental risk factors for birth defects and the association between birth defects and risk of growth retardation. Results: Prevalence of all birth defects was 18.9=1,000 births. The proportion of patients with birth defects delivered between 12 and 21 weeks of gestation was approximately one-tenth of all patients with birth defects. Among those with congenital malformation of the nerve system, 39% were delivered before 22 weeks of gestation. All patients with anencephaly and encephalocele were delivered before 22 weeks of gestation. We observed different patterns of parental risk factors between birth defect cases included in ISBDSR and cases not included. Cases included in ISBDSR were associated with an increased risk of preterm birth. Cases not included in ISBDSR were associated with an increased risk of being small for gestational age at term. Conclusions: Data from our study complemented the data from ICBDSR. We recommend that birth defects not included in ICBDSR also be analyzed to elucidate the etiology of birth defects.
• Modification of adverse health effects of maternal active and passive smoking by genetic susceptibility: Dose-dependent association of plasma cotinine with infant birth size among Japanese women-The Hokkaido Study

  Sumitaka Kobayashi, Fumihiro Sata, Seiko Sasaki, Titilola Serifat Braimoh, Atsuko Araki, Chihiro Miyashita, Houman Goudarzi, Sachiko Kobayashi, Reiko Kishi

  REPRODUCTIVE TOXICOLOGY 74 94 - 103 2017年12月 [査読有り][通常論文]
   

  Objectives: We aimed to assess the individual dose-response effects of eight maternal polymorphisms encoding polycyclic aromatic hydrocarbon-metabolizing and DNA-repair genes on prenatal cotinine levels according to infant birth size. Methods: In total, 3263 Japanese pregnant women were assigned to five groups based on plasma cotinine levels during the 8th month of pregnancy, as measured using ELISA (cut-offs: 0.21, 0.55, 11.48, and 101.67 ng/mL). Analyses were performed using multiple linear regression. Results: Birth weight reduction showed a dose-dependent relationship with prenatal cotinine levels (P for trend < 0.001). When considering the specific aromatic hydrocarbon receptor (AHR) (G >A, Arg554Lys; db SNP ID: rs2066853) and X-ray cross-complementing gene 1 (XRCC1) (C> T, Arg194Trp, rs1799782) genotypes, a larger birth weight reduction was noted among infants born to mothers with the highest cotinine level. Conclusion: Infants born to women with specific AHR and XRCC1 genotypes may have higher genetic risks for birth weight reduction. (C) 2017 Elsevier Inc. All rights reserved.
• Association of prenatal passive smoking and metabolic gene polymorphisms with child growth from birth to 3 years of age in the Hokkaido Birth Cohort Study on Environment and Children's Health

  Titilola Serifat Braimoh, Sumitaka Kobayashi, Fumihiro Sata, Seiko Sasaki, Houman Goudarzi, Thamar Ayo Yila, Atsuko Araki, Chihiro Miyashita, Hisanori Minakami, Tsuyoshi Baba, Kazuo Sengoku, Reiko Kishi

  SCIENCE OF THE TOTAL ENVIRONMENT 605 995 - 1002 2017年12月 [査読有り][通常論文]
   

  Although the effects of prenatal passive smoking on birth weight have been reported, the effects of metabolic gene polymorphisms on passive smoking have not been studied. Therefore, we investigated the effects of maternal passive smoking and metabolic gene polymorphisms on child growth up to 3 years of age using cotinine as a biomarker. We included 1356 Japanese participants in a prospective cohort between 2003 and 2007 (cotinine levels at the third trimester <= 0.21 ng/mL and 0.22 to 11.48 ng/mL for non-passive and passive smokers, respectively), and measured child outcomes such as weight, length, head circumference, and Kaup index. Additionally, we analyzed cytochrome P450 1A1 (CYP1A1), epoxide hydrolase 1 (EPHX1), and two N-acetyltransferase 2 (NAT2) genotypes using real-time polymerase chain reaction methods. Associations were investigated using multiple regression models. Kaup index gain from birth up to 3 years of age was significantly smaller in children born to passive smokers than in those born to non-passive smokers (-0.34 kg/m(2); 95% confidence interval: -0.67, -0.01). Maternal CYP1A1 genotype was not associated with prenatal passive smoking and Kaup index gain, but was significantly associated with prenatal passive smoking and head circumference gain from birth up to 3 years of age (-0.75 cm; 95% confidence interval:-1.39, -0.12). Thus, this study suggests that prenatal passive smoking may have potent effects on postnatal growth frombirth up to 3 years of age. Moreover, children with maternal CYP1A1 genotype may be more susceptible to the effects of prenatal passive smoking. (C) 2017 Elsevier B.V. All rights reserved.
• Gender-specific association of exposure to non-dioxin-like polychlorinated biphenyls during pregnancy with methylation levels of H19 and long interspersed nuclear element-1 in cord blood in the Hokkaido study

  Sumitaka Kobayashi, Fumihiro Sata, Chihiro Miyashita, Ryu Miura, Kaoru Azumi, Sachiko Kobayashi, Houman Goudarzi, Atsuko Araki, Mayumi Ishizuka, Takashi Todaka, Jumboku Kajiwara, Tsuguhide Hori, Reiko Kishi

  TOXICOLOGY 390 135 - 145 2017年09月 [査読有り][通常論文]
   

  Background: Associations between prenatal exposure to polychlorinated biphenyls (PCBs) and reduced birth size, and between DNA methylation of insulin-like growth factor-2 (IGF-2), HI 9 locus, and long interspersed nuclear element-1 (LINE-1) and reduced birth-size are well established. To date, however, studies on the associations between prenatal exposure to PCBs and alterations in methylation of IGF-2, H19, and LINE-1 are lacking. Thus, in this study, we examined these associations with infant-gender stratification. Methods: We performed a prospective birth cohort study using the Sapporo cohort from the previously described Hokkaido Birth Cohort Study on Environment and Children's Health conducted between 2002 and 2005 in Japan. In the final 169 study participants included in this study, we measured the concentrations of various non dioxin-like PCBs in maternal blood during pregnancy using high-resolution gas chromatography/high-resolution mass spectrometry. IGF-2, H19 and LINE-1 methylation levels in cord blood were measured using the bisulfite pyrosequencing methods Finally, we assessed the associations between prenatal exposure to various PCBs and the gene methylation levels using multiple regression models stratified by infant gender. Results: We observed a 0.017 (95% confidence interval [CI]: 0.003-0.031) increase in the log(10)-transformed H19 methylation levels (%) in cord blood for each ten-fold increase in the levels of decachlorinated biphenyls (decaCBs) in maternal blood among all infants. Similarly, a 0.005 (95% CI: 0.000-0.010) increase in the log(10)-transformed LINE-1 methylation levels (%) in cord blood was associated with each ten-fold increase in heptachlorinated biphenyls (heptaCBs) in maternal blood among all infants. In particular, we observed a dose-dependent association of the decaCB levels in maternal blood with the H19 methylation levels among female infants (P value for trend = 0.040); likewise a dose-dependent association of heptaCB levels was observed with LINE-I methylation levels among female infants (P value for trend = 0.015). Moreover, these associations were only observed among infants of primiparous women. Conclusion: Our results suggest that the dose-dependent association between prenatal exposure to specific non-dioxin-like PCBs and increases in the H19 and LINE-1 methylation levels in cord blood might be more predominant in females than in males.
• Prenatal exposure to perfluoroalkyl acids and prevalence of infectious diseases up to 4 years of age

  Houman Goudarzi, Chihiro Miyashita, Emiko Okada, Ikuko Kashino, Chi-Jen Chen, Sachiko Ito, Atsuko Araki, Sumitaka Kobayashi, Hideyuki Matsuura, Reiko Kishi

  ENVIRONMENT INTERNATIONAL 104 132 - 138 2017年07月 [査読有り][通常論文]
   

  Perfluoroalkyl acids (PFAAs) are synthetic chemicals with ability to repel oils and water, and have been widely used in many industrial and household applications such as adhesives and water-and stain-repellent surfaces to nonstick coatings. Animal studies have shown that PFAAs have immunotoxic effects. However, few epidemiological studies have investigated the effects of PFAAs on infectious diseases occurrence. We examined the relationship between prenatal exposure to PFAAs and prevalence of infectious diseases up to 4 years of life. A total of 1558 mother-child pairs, who were enrolled in the Hokkaido Study on Environment and Children's Health, were included in this data analysis. Eleven PFAAs were measured in maternal plasma taken at 28-32 weeks of gestation using ultra-performance liquid chromatography coupled to triple quadrupole tandem mass spectrometry. Participant characteristics were obtained from medical birth records and self-administered questionnaires during pregnancy and after delivery. Physicians' diagnosis of common infectious diseases including otitis media, pneumonia, respiratory syncytial virus infection, and varicella up to 4 years were extracted from the mother-reported questionnaires. The number of children who developed infectious diseases up to 4 years of age was as follows: otitis media, 649 (41.4%); pneumonia, 287 (18.4%); respiratory syncytial virus infection, 197 (12.6%); varicella 589 (37.8%). A total of 1046 (67.1%) children had at least one of the diseases defined as total infectious diseases. After adjusting for appropriate confounders, PFOS levels in the highest quartile were associated with increased odds ratios (ORs) of total infectious diseases (Q4 vs. Q1 OR: 1.61; 95% CI: 1.18, 2.21; p for trend = 0.008) in all children. In addition, perfluorohexane sulfonate (PFHxS) was associated with a higher risk of total infectious diseases only among girls (Q4 vs. Q1 OR: 1.55, 95% CI: 0.976, 2.45; p for trend = 0.045). We found no association between infectious diseases and other examined PFAAs. Our findings suggest that prenatal exposure to PFOS and PFHxS may associated with infectious diseases occurrence in early life. Therefore, prenatal exposure to PFAAs may be immunotoxic for the immune system in offspring. (C) 2017 Elsevier Ltd. All rights reserved.
• Association of prenatal exposure to perfluoroalkyl substances with cord blood adipokines and birth size: The Hokkaido Study on environment and children's health

  Machiko Minatoya, Sachiko Itoh, Chihiro Miyashita, Atsuko Araki, Seiko Sasaki, Ryu Miura, Houman Goudarzi, Yusuke Iwasaki, Reiko Kishi

  ENVIRONMENTAL RESEARCH 156 175 - 182 2017年07月 [査読有り][通常論文]
   

  Perfluoroalkyl substances (PFASs) are synthetic chemicals that persist in the environment and in humans. There is a possible association between prenatal PFASs exposure and both neonate adipokines and birth size, yet epidemiological studies are very limited. The objective of this study was to examine associations of prenatal exposure to PFASs with cord blood adipokines and birth size. We conducted birth cohort study, the Hokkaido Study. In this study, 168 mother-child pairs were included. Perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in maternal blood were determined by liquid chromatography tandem mass spectrometry. Cord blood adiponectin and leptin levels were measured by ELISA and RIA, respectively. Birth weight and ponderal index (PI) were obtained from birth record. The median maternal PFOS and PFOA were 5.1 and 1.4 ng/ mL, respectively. The median total adiponectin and leptin levels were 19.4 mu g/mL and 6.2 ng/mL, respectively. Adjusted linear regression analyses found that PFOS level was positively associated with total adiponectin levels (beta=0.12, 95% CI:0.01, 0.22), contrary was negatively associated with PI (beta=-2.25, 95% CI:-4.01,- 0.50). PFOA level was negatively associated with birth weight (beta=-197, 95% CI:- 391,- 3). Leptin levels were not associated with PFASs levels. PFOS and adiponectin levels showed marginal dose-response relationship and both PFOS and PFOA and birth size showed significant dose-response relationships. Results from this study suggested that prenatal PFASs exposure may alter cord blood adiponectin levels and may decrease birth size.
• Effects of prenatal perfluoroalkyl acid exposure on cord blood IGF2/H19 methylation and ponderal index: The Hokkaido Study

  Sachiko Kobayashi, Kaoru Azumi, Houman Goudarzi, Atsuko Araki, Chihiro Miyashita, Sumitaka Kobayashi, Sachiko Itoh, Seiko Sasaki, Mayumi Ishizuka, Hiroyuki Nakazawa, Tamiko Ikeno, Reiko Kishi

  JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY 27 3 251 - 259 2017年05月 [査読有り][通常論文]
   

  Prenatal exposure to perfluoroalkyl acids (PFAAs) influences fetal growth and long-term health. However, whether PFAAs affect offspring DNA methylation patterns to influence health outcomes is yet to be evaluated. Here, we assessed effect of prenatal PFAA exposure on cord blood insulin-like growth factor 2 (IGF2), H19, and long interspersed element 1 (LINE1) methylation and its associations with birth size. Mother-child pairs (N = 177) from the Hokkaido Study on Environment and Children's Health were included in the study. Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) levels in maternal serum were measured by liquid chromatography-tandem mass spectrometry. IGF2, H19, and LINE1 methylation in cord blood DNA was determined by pyrosequencing. After full adjustment in multiple linear regression models, IGF2 methylation showed a significant negative association with log-unit increase in PFOA (partial regression coefficient = -0.73; 95% confidence interval: -1.44 to -0.02). Mediation analysis suggested that reduced IGF2 methylation explained similar to 21% of the observed association between PFOA exposure and reduced ponderal index of the infant at birth. These results indicated that the effects of prenatal PFOA exposure could be mediated through DNA methylation. Further study will be required to determine the potential for long-term adverse health effects of reduced IGF2 methylation induced by PFOA exposure.
• 肥満の重症喘息患者におけるclub cell 16-kDa分泌タンパク質(CC16)とCCケモカインリガンド18(CCL18)の重要な役割(Potential roles of club cell 16-kDa secretory protein(CC16) and CC chemokine ligand 18(CCL18) in obese severe asthmatic patients)

  Goudarzi Houman, Konno Satoshi, Makita Hironi, Kimura Hirokazu, Kimura Hiroki, Shimizu Kaoruko, Suzuki Masaru, Nishimura Masaharu

  アレルギー 66 4-5 502 - 502 2017年05月
• Prenatal di(2-ethylhexyl) phthalate exposure and disruption of adrenal androgens and glucocorticoids levels in cord blood: The Hokkaido Study

  Atsuko Araki, Takahiko Mitsui, Houman Goudarzi, Tamie Nakajima, Chihiro Miyashita, Sachiko Itoh, Seiko Sasaki, Kazutoshi Cho, Kimihiko Moriya, Nobuo Shinohara, Katsuya Nonomura, Reiko Kishi

  SCIENCE OF THE TOTAL ENVIRONMENT 581 297 - 304 2017年03月 [査読有り][通常論文]
   

  Di(2-ethylhexyl) phthalate (DEHP) is known for its endocrine disrupting properties. We previously demonstrated that prenatal DEHP exposure is associated with decreased progesterone levels and testosterone/estradiol ratio in the cord blood. However, evidence of the effects of prenatal DEHP exposure on adrenal androgen and glucocorticoids in infants is scarce. Thus, the objectives of this study were to investigate the association between prenatal DEHP exposure and adrenal androgen and glucocorticoids, and to discuss its effects on steroid hormone profiles in infants. This is part of a birth cohort study: The Hokkaido Study on Environment and Children's Health, Sapporo Cohort. Among the 514 participants, 202 mother-infant pairs with available data on maternal mono (2ethylhexyl) phthalate (MEHP), adrenal androgen (dehydroepiandrostenedione [DHEA] and androstenedione) and glucocorticoid (cortisol and cortisone) cord blood levels were included in this study. After adjusting for potential confounders, a linear regression analysis showed that maternal MEHP levels were associated with reduced cortisol and cortisone levels and glucocorticoid/adrenal androgen ratio, whereas increased DHEA levels and DHEA/androstenedione ratio. In a quartile model, when comparing the adjusted least square means in the 4th quartile of MEHP with those in the 1st quartile, cortisol and cortisone levels and glucocorticoid/adrenal androgen ratio decreased, whereas DHEA/androstenedione and cortisol/cortisone ratios increased. Significant p-value trends for cortisol and cortisone levels, cortisol/cortisone ratio, and glucocorticoid/adrenal androgen ratio were observed. In combination with the previous results of reduced progesterone levels and testosterone/estradiol ratio, prenatal exposure to DEHP altered the steroid hormone profiles of infants. Further studies investigating the long-term effects of DEHP exposure on growth, neurodevelopment, and gonad and reproductive function are required. (C) 2016 Elsevier B.V. All rights reserved.
• The Association of Prenatal Exposure to Perfluorinated Chemicals with Glucocorticoid and Androgenic Hormones in Cord Blood Samples: The Hokkaido Study

  Houman Goudarzi, Atsuko Araki, Sachiko Itoh, Seiko Sasaki, Chihiro Miyashita, Takahiko Mitsui, Hiroyuki Nakazawa, Katsuya Nonomura, Reiko Kishi

  ENVIRONMENTAL HEALTH PERSPECTIVES 125 1 111 - 118 2017年01月 [査読有り][通常論文]
   

  BACKGROUND: Perfluorinated chemicals (PFCs) disrupt cholesterol homeostasis. All steroid hormones are derived from cholesterol, and steroid hormones such as glucocorticoids and androgenic hormones mediate several vital physiologic functions. However, the in utero effects of PFCs exposure on the homeostasis of these steroid hormones are not well understood in humans. OBJECTIVES: We examined the relationship between prenatal exposure to perfluorooctane sulfonate (PFOS)/perfluorooctanoate (PFOA) and cord blood levels of glucocorticoid and androgenic hormones. METHODS: We conducted a hospital-based birth cohort study between July 2002 and October 2005 in Sapporo, Japan (n = 514). In total, 185 mother-infant pairs were included in the present study. Prenatal PFOS and PFOA levels in maternal serum samples were measured using liquid chromatography-tandem mass spectrometry (LC-MS-MS). Cord blood levels of glucocorticoid (cortisol and cortisone) and androgenic hormones [dehydroepiandrosterone (DHEA) and androstenedione] were also measured in the same way. RESULTS: We found a dose-response relationship of prenatal PFOS, but not PFOA, exposure with glucocorticoid levels after adjusting for potential confounders. Cortisol and cortisone concentrations were -23.98-ng/mL (95% CI: -0.47.12, -11.99; p for trend = 0.006) and -63.21-ng/mL (95% CI: -132.56, -26.72; p for trend < 0.001) lower, respectively, in infants with prenatal PFOS exposure in the fourth quartile compared with those in the first quartile. The highest quartile of prenatal PFOS exposure was positively associated with a 1.33-ng/mL higher DHEA level compared with the lowest quartile (95% CI: 0.17, 1.82; p for trend = 0.017), whereas PFOA showed a negative association with DHEA levels (quartile 4 vs. quartile 1: -1.23 ng/mL, 95% CI: -1.72, -0.25; p for trend = 0.004). We observed no significant association between PFCs and androstenedione levels. CONCLUSIONS: Our results indicate that prenatal exposure to PFCs is significantly associated with glucocorticoid and DHEA levels in cord blood.
• Dioxin-metabolizing genes in relation to effects of prenatal dioxin levels and reduced birth size: The Hokkaido study

  Sumitaka Kobayashi, Fumihiro Sata, Chihiro Miyashita, Seiko Sasaki, Susumu Ban, Atsuko Araki, Houman Goudarzi, Jumboku Kajiwara, Takashi Todaka, Reiko Kishi

  REPRODUCTIVE TOXICOLOGY 67 111 - 116 2017年01月 [査読有り][通常論文]
   

  Objectives: We investigated the effects of maternal polymorphisms in 3 genes encoding dioxin metabolizing enzymes in relation to prenatal dioxin levels on infant birth size in Japan. Methods: We examined the relationship between dioxin exposure and birth size in relation to the polymorphisms in the genes encoding aromatic hydrocarbon receptor (AHR [G > A, Arg554Lys]), cytochrome P450 (CYP) 1A1 (T6235C), and glutathione S-transferase mu I (GSTM1; Non-null/null) in 421 participants using multiple linear regression models. Results: In mothers carrying the GSTM1 null genotype, a ten-fold increase in total dioxin toxic equivalency was correlated with a decrease in birth weight of -345g (95% confidence interval: -584, -105). Conclusions: We observed adverse effects of maternal GSTM1 null genotype on birth weight in the presence of dioxins exposure during pregnancy. (C) 2016 Elsevier Inc. All rights reserved.
• The Hokkaido Birth Cohort Study on Environment and Children's Health: cohort profile-updated 2017

  Reiko Kishi, Atsuko Araki, Machiko Minatoya, Tomoyuki Hanaoka, Chihiro Miyashita, Sachiko Itoh, Sumitaka Kobayashi, Yu Ait Bamai, Keiko Yamazaki, Ryu Miura, Naomi Tamura, Kumiko Ito, Houman Goudarzi

  ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE 22 1 46  2017年 [査読有り][通常論文]
   

  The Hokkaido Study on Environment and Children's Health is an ongoing study consisting of two birth cohorts of different population sizes: the Sapporo cohort and the Hokkaido cohort. Our primary study goals are (1) to examine the effects of low-level environmental chemical exposures on birth outcomes, including birth defects and growth retardation; (2) to follow the development of allergies, infectious diseases, and neurobehavioral developmental disorders and perform a longitudinal observation of child development; (3) to identify high-risk groups based on genetic susceptibility to environmental chemicals; and (4) to identify the additive effects of various chemicals, including tobacco smoking. The purpose of this report is to update the progress of the Hokkaido Study, to summarize the recent results, and to suggest future directions. In particular, this report provides the basic characteristics of the cohort populations, discusses the population remaining in the cohorts and those who were lost to follow-up at birth, and introduces the newly added follow-up studies and case-cohort study design. In the Sapporo cohort of 514 enrolled pregnant women, various specimens, including maternal and cord blood, maternal hair, and breast milk, were collected for the assessment of exposures to dioxins, polychlorinated biphenyls, organochlorine pesticides, perfluoroalkyl substances, phthalates, bisphenol A, and methylmercury. As follow-ups, face-to-face neurobehavioral developmental tests were conducted at several different ages. In the Hokkaido cohort of 20,926 enrolled pregnant women, the prevalence of complicated pregnancies and birth outcomes, such as miscarriage, stillbirth, low birth weight, preterm birth, and small for gestational age were examined. The levels of exposure to environmental chemicals were relatively low in these study populations compared to those reported previously. We also studied environmental chemical exposure in association with health outcomes, including birth size, neonatal hormone levels, neurobehavioral development, asthma, allergies, and infectious diseases. In addition, genetic and epigenetic analyses were conducted. The results of this study demonstrate the effects of environmental chemical exposures on genetically susceptible populations and on DNA methylation. Further study and continuous follow-up are necessary to elucidate the combined effects of chemical exposure on health outcomes.
• Combined effects of AHR, CYP1A1, and XRCC1 genotypes and prenatal maternal smoking on infant birth size: Biomarker assessment in the Hokkaido Study

  Sumitaka Kobayashi, Fumihiro Sata, Seiko Sasaki, Titilola Serifat Braimoh, Atsuko Araki, Chihiro Miyashita, Houman Goudarzi, Sachiko Kobayashi, Reiko Kishi

  REPRODUCTIVE TOXICOLOGY 65 295 - 306 2016年10月 [査読有り][通常論文]
   

  Objectives: We investigated the individual and combined effects of maternal polymorphisms encoding the aromatic hydrocarbon receptor (AHR; rs2066853), cytochrome P450 (CYP) 1A1 (rs1048963), and the X-ray-complementing gene 1 (XRCC1; rs1799782) and prenatal smoking in relation to infant birth size. Methods: Totally, 3263 participants (1998 non-smokers and 1265 smokers) were included in the study between 2003 and 2007. Two groups of mothers were distinguished by plasma cotinine levels by ELISA measured during the third trimester (cut-off= 11.48 ng/mL). We conducted data analysis using multiple linear regression models. Results: Infants whose mothers smoked and had AHR-GG, CYP1A1-AG/GG, and XRCC1-CT/TT genotypes weighed, -145 g less than those born of mothers who did not smoke and had the AHR-GA/AA, CYP1A1-AA, and XRCC1-CC genotypes (95% CI: 241, 50). Conclusions: We demonstrated that infants whose mothers smoked during pregnancy with the combination of AHR, CYP1A1, and XRCC1 polymorphisms had lower birth size. (C) 2016 Elsevier Inc. All rights reserved.
• Association of perfluoroalkyl substances exposure in utero with reproductive hormone levels in cord blood in the Hokkaido Study on Environment and Children's Health

  Sachiko Itoh, Atsuko Araki, Takahiko Mitsui, Chihiro Miyashita, Houman Goudarzi, Seiko Sasaki, Kazutoshi Cho, Hiroyuki Nakazawa, Yusuke Iwasaki, Nobuo Shinohara, Katsuya Nonomura, Reiko Kishi

  ENVIRONMENT INTERNATIONAL 94 51 - 59 2016年09月 [査読有り][通常論文]
   

  Background: Exposure to perfluoroalkyl substances (PFASs) may disrupt reproductive function in animals and humans. Although PFASs can cross the human placental barrier, few studies evaluated the effects of prenatal PFAS exposure on the fetus' reproductive hormones. Objective: To explore the associations of prenatal exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) with cord blood reproductive hormones. Methods: In the prospective birth cohort (Sapporo cohort of the Hokkaido study), we included 189 mother-infant pairs recruited in 2002-2005 with both prenatal maternal and cord blood samples. PFOS and PFOA levels in maternal blood after the second trimester were measured via liquid chromatography-tandem mass spectrometry. We also measured cord blood levels of the fetuses' reproductive hormones, including estradiol (E2), total testosterone (T), progesterone (P4), inhibin B, insulin-like factor 3, steroid hormone binding globulin, follicle-stimulating hormone, and luteinizing hormone, and prolactin (PRL). Results: The median PFOS and PFOA levels in maternal serum were 5.2 ng/mL and 1.4 ng/mL, respectively. In the fully adjusted linear regression analyses of the male infants, maternal PFOS levels were significantly associated with E2 and positively, and T/E2, P4, and inhibin B inversely; PFOA levels were positively associated with inhibin B levels. Among the female infants, there were significant inverse associations between PFOS levels and P4 and PRL levels, although there were no significant associations between PFOA levels and the female infants' reproductive hormone levels. Conclusions: These results suggest that the fetal synthesis and secretion of reproductive hormones may be affected by in utero exposure to measurable levels of PFOS and PFOA. (C) 2016 Elsevier Ltd. All rights reserved.
• Effects of prenatal exposure to perfluoroalkyl acids on prevalence ofallergic diseases among 4-year-old children

  Houman Goudarzi, Chihiro Miyashita, Emiko Okada, Ikuko Kashino, Sumitaka Kobayashi, Chi-Jen Chen, Sachiko Ito, Atsuko Araki, Hideyuki Matsuura, Yoichi M. Ito, Reiko Kishi

  ENVIRONMENT INTERNATIONAL 94 124 - 132 2016年09月 [査読有り][通常論文]
   

  Perfluoroalkyl acids (PFAAs) are ubiquitous chemicals extremely resistant and widespread throughout the environment, frequently being detected in human blood samples. Animal studies have revealed that exposure to PFAAs results in immunotoxicity. However, the association between PFAAs, especially long-chain PFAAs, and allergies in humans is not well established. We examined whether prenatal exposure to PFAAs is associated with allergic diseases among 4-year-old children in a large-scale prospective birth cohort in Hokkaido, Japan. In total, 1558 mother-child pairs were included in this study and prenatal levels of eleven PFAAs were measured in maternal plasma samples obtained between 28 and 32 weeks of pregnancy by using ultra-performance liquid chromatography-tandem mass spectrometry. Participant demographic and characteristic information were obtained from self-administered pre- and postnatal questionnaires and medical birth records. Infant allergies were assessed using the Japanese version of the International Study of Asthma and Allergies in Childhood (ISAAC) Phase Three questionnaire, which was administered 4 years post-delivery. Symptoms included eczema, wheezing and rhinoconjunctivitis with a prevalence of 19.0%, 18.7%, and 5.4%, respectively. Associations of PFAA quartiles with allergic outcomes were examined using logistic models. Adjusted odds ratios (ORs) in the 4th quartile vs. 1st quartile (Q4 vs. Q1) for total allergic diseases (including at least one allergic outcome) significantly decreased for perfluorododecanoic acid (PFDoDa) (Q4 vs. Q1 OR: 0.621; 95% confidence interval (CI): 0.454, 0.847) andperfluorotridecanoic acid (PFTrDA) (Q4 vs. Q1 OR: 0.712; 95% CI: 0.524, 0.966) in all children. We obtained similar results when examining the association between PFAAs and eczema. The adjusted OR (Q4 vs. Q1) for wheezing in relation to higher maternal PFHxS levels was 0.728 (95% CI: 0.497, 1.06) in all children. In conclusion, prenatal exposure to long-chain PFAAs, such as PFDoDa and PFTrDA may have an immunosuppressive effect on allergic diseases in 4-year-old children. (C) 2016 Published by Elsevier Ltd.
• Effects of adrenal androgens during the prenatal period on the second to fourth digit ratio in school-aged children

  Takahiko Mitsui, Atsuko Araki, Houman Goudarzi, Chihiro Miyashita, Sachiko Ito, Seiko Sasaki, Takeya Kitta, Kimihiko Moriya, Kazutoshi Cho, Keita Morioka, Reiko Kishi, Nobuo Shinohara, Masayuki Takeda, Katsuya Nonomura

  STEROIDS 113 46 - 51 2016年09月 [査読有り][通常論文]
   

  Objectives: We investigated the relationship between the levels of adrenal steroid hormones in cord blood and the second to fourth digit ratio (2D/4D), which is regarded as an indirect method to investigate the putative effects of prenatal exposure to androgens, in school-aged children. Materials and methods: Of the 514 mother-child pairs who participated in the prospective cohort study of birth in Sapporo between 2002 and 2005, the following adrenal steroid hormone levels in 294 stored cord blood samples (135 males and 159 females) were measured; cortisol, cortisone, androstenedione and dehydroepiandrosterone (DHEA). A total of 190 out of 350 children who were currently school-aged and contactable for this survey sent back photocopies of their palms for 2D/4D measurements. Results: 2D/4D in all right hands, left hands, and mean values was significantly lower in males than in females (p < 0.01). DHEA levels were significantly higher in females. A multivariate regression model showed that 2D/4D negatively correlated with DHEA in males only (p < 0.01). No correlations were observed in the other adrenal steroid hormones tested in males or in any adrenal steroid hormones in females. Conclusion: DHEA is mainly secreted in large amounts by the adrenal gland and is transformed into active sex-steroid hormones in peripheral tissues. The present study demonstrated that sex differences in digits were influenced by adrenal androgens during the prenatal period, possibly through intracrinological processes for androgen receptors located in fetal cartilaginous tissues. (C) 2016 Elsevier Inc. All rights reserved.
• Predictors of folate status among pregnant Japanese women: the Hokkaido Study on Environment and Children's Health, 2002-2012

  Thamar A. Yila, Atsuko Araki, Seiko Sasaki, Chihiro Miyashita, Kumiko Itoh, Tamiko Ikeno, Eiji Yoshioka, Sumitaka Kobayashi, Houman Goudarzi, Toshiaki Baba, Titilola Braimoh, Hisanori Minakami, Toshiaki Endo, Kazuo Sengoku, Reiko Kishi

  BRITISH JOURNAL OF NUTRITION 115 12 2227 - 2235 2016年06月 [査読有り][通常論文]
   

  The International Clearinghouse for Birth Defects, Surveillance and Research reports a rise in the prevalence rate of spina bifida in Japan. We determined first-trimester folate status of Hokkaido women and identified potential predictors. Participants were 15 266 pregnant women of the Hokkaido Study on Environment and Children's Health Cohort. Data were extracted from self-reported questionnaires and biochemical assay results. Demographic determinants of low folate status were younger maternal age (adjusted OR (AOR) 1.48; 95% CI 1.32, 1.66), lower educational level (AOR 1.27; 95% CI 1.17, 1.39) and lower annual income (AOR 1.11; 95% CI 1.01, 1.22). Plasma cotinine concentrations of 1.19-65.21 nmol/l increased the risk of low folate status (AOR 1.20; 95% CI 1.10, 1.31) and concentrations > 65.21 nmol/l further increased the risk (AOR 1.91; 95% CI 1.70, 2.14). The most favourable predictor was use of folic acid (FA) supplements (AOR 0.19; 95% CI 0.17, 0.22). Certain socio-demographic factors influence folate status among pregnant Japanese women. Modifiable negative and positive predictors were active and passive tobacco smoking and use of FA supplements. Avoiding both active and passive tobacco smoking and using FA supplements could improve the folate status of Japanese women.
• Prenatal exposure to perfluorinated chemicals and neurodevelopment in early infancy: The Hokkaido Study

  Houman Goudarzi, Sonomi Nakajima, Tamiko Ikeno, Seiko Sasaki, Sachiko Kobayashi, Chihiro Miyashita, Sachiko Ito, Atsuko Araki, Hiroyuki Nakazawa, Reiko Kishi

  SCIENCE OF THE TOTAL ENVIRONMENT 541 1002 - 1010 2016年01月 [査読有り][通常論文]
   

  Perfluorinated chemicals (PFCs) are ubiquitous and persistent pollutants widely detected in blood samples of animals and humans across the globe. Although animal studies have shown the potential neurotoxicity of PFCs, there are few epidemiological studies regarding neurological effects of PFCs in humans, and those studies have had inconclusive results. In this study, we conducted a hospital-based prospective birth cohort study between 2002 and 2005 (n = 514) to examine the associations between prenatal perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) exposures and the neurodevelopment of infants at 6 (n = 173) and 18 (n = 133) months of age. Using the second edition of the Bayley Scales of Infant Development (BSID II), the Mental and Psychomotor Developmental Indices (MDI and PDI, respectively) were assessed. PFOS and PFOA were measured in maternal serum samples by liquid chromatography-tandem mass spectrometry. After controlling for confounders, prenatal PFOA concentrations were associated with the MDI of female (but not male) infants at 6 months of age (beta = -0.296; 95% confidence interval (CI): -11.96, -0.682). Furthermore, females born to mothers with prenatal concentrations of PFOA in the fourth quartile had MDI scores -5.05 (95% CI: -10.66 to 0.55) lower than females born to mothers with concentrations of PFOA in the first quartile (p for trend = 0.045). However, PFOA concentrations were not significantly associated with neurodevelopmental indices at 18 months of age. In addition, we did not observe any significant association between PFOS concentrations and neurodevelopmental outcomes in early infancy. In conclusion, our results suggest that prenatal PFOA exposure may affect female mental scales of neurodevelopment at 6 months of age. Further studies with larger sample sizes and longer observation periods are required to clarify sex difference of the neurodevelopmental effects. (C) 2015 Elsevier B.V. All rights reserved.
• The Association of Prenatal Exposure to Perfluorinated Chemicals with Maternal Essential and Long-Chain Polyunsaturated Fatty Acids during Pregnancy and the Birth Weight of Their Offspring: The Hokkaido Study

  Reiko Kishi, Tamie Nakajima, Houman Goudarzi, Sachiko Kobayashi, Seiko Sasaki, Emiko Okada, Chihiro Miyashita, Sachiko Itoh, Atsuko Araki, Tamiko Ikeno, Yusuke Iwasaki, Hiroyuki Nakazawa

  ENVIRONMENTAL HEALTH PERSPECTIVES 123 10 1038 - 1045 2015年10月 [査読有り][通常論文]
   

  BACKGROUND: Fatty acids (FAs) are essential for fetal growth. Exposure to perfluorinated chemicals (PFCs) may disrupt FA homeostasis, but there are no epidemiological data regarding associations of PFCs and FA concentrations. OBJECTIVES: We estimated associations between perfluorooctane sulfonate (PFOS)/perfluoro-octanoate (PFOA) concentrations and maternal levels of FAs and triglyceride (TG) and birth size of the offspring. METHODS: We analyzed 306 mother-child pairs in this birth cohort between 2002 and 2005 in Japan. The prenatal PFOS and PFOA levels were measured in maternal serum samples by liquid chromatography-tandem mass spectrometry. Maternal blood levels of nine FAs and TG were measured by gas chromatography-mass spectrometry and TG E-Test Wako kits, respectively. Information on infants' birth size was obtained from participant medical records. RESULTS: The median PFOS and PFOA levels were 5.6 and 1.4 ng/mL, respectively. In the fully adjusted model, including maternal age, parity, annual household income, blood sampling period, alcohol consumption, and smoking during pregnancy, PFOS but not PFOA had a negative association with the levels of palmitic, palmitoleic, oleic, linoleic, alpha-linolenic, and arachidonic acids (p < 0.005) and TG (p-value = 0.016). Female infants weighed 186.6 g less with mothers whose PFOS levels were in the fourth quartile compared with the first quartile (95% CI: -363.4, -9.8). We observed no significant association between maternal levels of PFOS and birth weight of male infants. CONCLUSIONS: Our data suggest an inverse association between PFOS exposure and polyunsaturated FA levels in pregnant women. We also found a negative association between maternal PFOS levels and female birth weight.
• Enhancement of in vitro cell motility and invasiveness of human malignant pleural mesothelioma cells through the HIF-1α-MUC1 pathway.

  Goudarzi H, Iizasa H, Furuhashi M, Nakazawa S, Nakane R, Liang S, Hida Y, Yanagihara K, Kubo T, Nakagawa K, Kobayashi M, Irimura T, Hamada J

  Cancer letters 339 1 82 - 92 2013年10月 [査読有り][通常論文]
   

  In this study, we examined the effects of hypoxia on the malignancy of human malignant pleural mesothelioma (MPM) cell lines, and found (I) hypoxia enhanced motility and invasiveness of human malignant pleural mesothelioma (MPM) cells; (2) this phenomenon resulted from increased expression of sialylated MUC1 through the activation of HIF-1 pathway; (3) two HIF-binding sites located in the promoter region of MUC1 were important for MUC1 transactivation under hypoxia. These findings are useful for better understanding molecular mechanisms of aggressive behavior of MPM cells and for targeting them in the clinical therapies for MPM patients. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
• Isolation and characterization of human breast cancer cells with SOX2 promoter activity

  Shanshan Liang, Masako Furuhashi, Rie Nakane, Seitaro Nakazawa, Houman Goudarzi, Jun-ichi Hamada, Hisashi Iizasa

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 437 2 205 - 211 2013年07月 [査読有り][通常論文]
   

  Sex determining region Y-box 2 (SOX2) is well known as one of the "sternness" factors and is often expressed in cancers including breast cancer. In this study, we developed a reporter system using fluorescent protein driven by the promoter for SOX2 gene to detect and isolate living SOX2-positive cells. Using this system, we determined that SOX2 promoter activities were well correlated with SOX2 mRNA expression levels in 5 breast cancer cell lines, and that the cell population with positive SOX2 promoter activity (pSp-T+) isolated from one of the 5 cell lines, MCF-7 cells, showed a high SOX2 protein expression and high sphere-forming activity compared with very low promoter activity (pSp-Tlow/-). The pSp-T(+)pbpulation expressed higher mRNA levels of several stemness-related genes such as CD44, ABCB1, NANOG and TWIST] than the pSp-Tlow/- population whereas the two populations expressed CD24 at similar levels. These results suggest that the cell population with SOX2 promoter activity contains cancer stem cell (CSC)-like cells which show different expression profiles from those of CSC-marker genes previously recognized in human breast cancers. (C) 2013 Elsevier Inc. All rights reserved.
• Hypoxia affects in vitro growth of newly established cell lines from patients with malignant pleural mesothelioma

  Houman Goudarzi, Yasuhiro Hida, Hiroko Takano, Hiroki Teramae, Hisashi Iizasa, Jun-ichi Hamada

  BIOMEDICAL RESEARCH-TOKYO 34 1 13 - 21 2013年02月 [査読有り][通常論文]
   

  Human malignant pleural mesothelioma (MPM) is highly aggressive, and its prognosis is very poor. For an early diagnosis of MPM and developing new therapeutic strategies against the malignancy, it is necessary to better understand biological characteristics of MPM. In this study, we established two cell lines from pleural effusions derived from patients with MPM. Both cell lines expressed tumor markers of mesothelioma such as mesothelin, podoplanin, WT1, calretinin and keratin 5/6 whereas they did not express either CEA or TTF-1 which are often used as markers of lung adenocarcinoma. The cell lines harboured wild-type TP53, produced hyaluronic acid, and were not infected with SV40. When these two cell lines were cultured under hypoxia (1% O-2), they showed particular responses to the hypoxic condition, distinct from those to normoxic condition (21% O-2). Namely, the ability to form a colony originating from a single cell (plating efficiency and cloning efficiency) was stimulated under hypoxia in both cell lines. On the other hand, when the assays of cell growth were started at a relatively high cell density, the growth of both cell lines, regardless of anchorage-dependent or -independent, decreased under hypoxia. The differences of their growth between under hypoxia and under normoxia, and those depending on the cell density, may provide useful hints for developing a new strategy for diagnosis or therapy of MPM.

書籍

• Health Impacts of Developmental Exposure to Environmental Chemicals

  Reiko Kishi, Philippe Grandjean, Atsuko Araki, Youssef Oulhote, David C. Bellinger, Eunhee Ha, Chihiro Miyashita, Shu-Li Wang, Kyungho Choi, John M. Rogers, Wilfried Karmaus, Martine Vrijheid, Houman Goudarzi (担当:共著)
  Springer 2020年01月

講演・口頭発表等

• Impact of COVID-19 on medical English education: Subjective and objective surveys between 2016 and 2020.

  Houman Goudarzi, Masahiro Onozawa, Makoto Takahashi

  The 53rd Annual Meeting of the Japan Society for Medical Education (JSME) (online) 口頭発表（一般）
• Impact of COVID-19 on medical English education: Subjective and objective surveys between 2016 and 2020.

  Houman Goudarzi, Masahiro Onozawa, Makoto Takahashi

  24th Japanese Society for Medical English Education (JASMEE) Academic Meeting (online) 口頭発表（一般）
• Prevalence and time trends of allergic disease among Japanese children: Interpretation of T helper 2 biomarker levels for clinical applications.

  Houman Goudarzi, Atsuko Araki, Chihiro Miyashita, Yu Ait Bamai, Sachiko Ito, Reiko Kishi, Masaharu Nishimura, Satoshi Konno

  JSA/WAO Joint Congress 2020, Kyoto, Japan
• Effects of an omnibus medical English course on English skills among undergraduate medical students.

  Houman Goudarzi, Masahiro Onozawa, Junji Otaki, Manabu Murakami, Makoto Takahashi.

  The 52nd Annual Meeting of the Japan Society for Medical Education (JSME), Kagoshima, Japan. ポスター発表
• Annual change in pulmonary function and related factors in severe asthmatic patients.

  木村孔一, 牧田比呂仁, 谷口菜津子, 木村裕樹, 清水薫子, 鈴木雅, 武井望, 松本宗大, Goudarzi Houman, 西村正治, 今野哲

  The 60th Annual Meeting of the Japanese Respiratory Society, April 20-22nd 2020, Nagoya, Japan. 口頭発表（一般）
• Mixture Chemical Exposure in Utero and Boys Reproductive Hormone Levels at Birth: the Hokkaido study.  [通常講演]

  フーマン グーダルズィ

  ISEEISES-AC, Daegu, Korea. 2019年10月 ポスター発表
• Childhood allergies and obesity relationship: identification of non-invasive biomarkers.  [通常講演]

  フーマン グーダルズィ

  European Respiratory Society International Congress, Madrid, Spain. 2019年09月 口頭発表（一般）
• EFFECT OF PRENATAL EXPOSURE TO PERFLUOROALKYL SUBSTANCES (PFAS) ON CHILDHOOD ALLERGIES: THE HOKKAIDO STUDY.  [通常講演]

  フーマン グーダルズィ

  39th International Symposium on Halogenated Persistent Organic Pollutants, Kyoto, Japan. 2019年08月 口頭発表（一般）
• English proficiency improvement in Japanese medical students using Omnibus style English exposure.  [通常講演]

  フーマン グーダルズィ

  The 51st Annual Meeting of the Japan Society for Medical Education (JSME) 2019年07月 ポスター発表
• Contrasting associations of maternal smoking and pre-pregnancy BMI with wheeze and eczema in children.  [招待講演]

  フーマン グーダルズィ

  2019年06月 口頭発表（招待・特別）
• Differential impact of obesity indices on systemic and sputum inflammatory biomarkers among asthma patients.  [通常講演]

  フーマン グーダルズィ

  The 59th Annual Meeting of the Japanese Respiratory Society, Tokyo, Japan. 2019年04月 口頭発表（一般）
• Distinct impact of abdominal visceral adiposity on asthma symptoms.  [通常講演]

  フーマン グーダルズィ

  European Respiratory Society International Congress, Paris, France 2018年09月 口頭発表（一般）
• Effect of prenatal exposure to perfluoroalkyl substances on childhood infectious diseases up to 7 years of age: The Hokkaido Study.  [通常講演]

  フーマン グーダルズィ

  The Joint Annual Meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology (ISES-ISEE), Ottawa, Canada 2018年08月 ポスター発表
• Contrasting associations of maternal smoking and BMI with wheeze and eczema in children.  [通常講演]

  フーマン グーダルズィ

  Japanese Society of Allergology (JSA) 67th Annual Meeting, Chiba, Japan. 2018年06月 口頭発表（一般）
• Prenatal exposure to perfluorinated alkyl substances and childhood ADHD risk at 6 years old: the Hokkaido Study on Environment and Children’s Health.  [通常講演]

  フーマン グーダルズィ

  Meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology (ISES-ISEE), Asia Chapter, Taipei, Taiwan 2018年06月 ポスター発表
• Distinct impact of abdominal visceral adiposity on asthma symptoms.  [通常講演]

  フーマン グーダルズィ

  The 58th Annual Meeting of the Japanese Respiratory Society, Osaka, Japan. 2018年04月 口頭発表（一般）
• Potential roles of club cell 16-kDa secretory protein (CC16) and CC chemokine ligand 18 (CCL18) in obese severe asthmatic patients.  [通常講演]

  フーマン グーダルズィ

  Japanese Society of Allergology (JSA) 66th Annual Meeting, Tokyo, Japan. 2017年06月 口頭発表（一般）
• Potential roles of club cell 16-kDa secretory protein (CC16) and CC chemokine ligand 18 (CCL18) in obese severe asthmatic patients.  [通常講演]

  フーマン グーダルズィ

  American Thoracic Society (ATS) International Conference, Washington, USA 2017年05月 ポスター発表
• Maternal exposure to endocrine disrupting chemicals (perfluoro-alkyls, phthalates and PCB/dioxins) and children’s reproductive hormone levels at birth; the Hokkaido Study on Environments and Children’s Health.  [招待講演]

  フーマン グーダルズィ

  25th EPICOH - Epidemiology in Occupation Health Conference, Spain 2016年09月 口頭発表（一般）
• Effects of prenatal exposure to perfluoroalkyl acids on risk of allergic and infectious diseases in early life.  [通常講演]

  フーマン グーダルズィ

  28th conference for International Society for Environmental Epidemiology (ISEE), Rome, Italy 2016年09月 ポスター発表
• Combined effects of AHR, CYP1A1 and XRCC1 genetic polymorphisms and prenatal maternal smoking on infant birth size: The Hokkaido Study on Environmental and Children’s Health.  [通常講演]

  フーマン グーダルズィ

  ISEE-ISES AC, Sapporo, Japan 2016年06月 口頭発表（一般）
• Endocrine Disruption Effect of perfluoroalkyl substances exposure in utero: Hokkaido Study on Environment and Children’s Health.  [通常講演]

  フーマン グーダルズィ

  ISEE-ISES AC 2016, Sapporo, Japan. 2016年06月 口頭発表（一般）
• Effects of prenatal exposure to perfluoroalkyl acids on risk of allergic and infectious diseases in early life.  [通常講演]

  フーマン グーダルズィ

  ISEE-ISES AC, Sapporo, Japan. 2016年06月 口頭発表（一般）
• Effects of environmental exposure and genetic polymorphisms on children’s birth size.  [招待講演]

  フーマン グーダルズィ

  The 18th Hokkaido University (HU) and Seoul National University (SNU) Joint Symposium. Seoul, South Korea. 2015年11月 ポスター発表
• Exposure to perfluoroalkyl chemicals and neurodevelopment at 6 months of age  [招待講演]

  フーマン グーダルズィ

  The 18th Hokkaido University (HU) and Seoul National University (SNU) Symposium, Seoul, South Korea 2015年11月 ポスター発表
• The Association of Prenatal Exposure to Perfluorinated Chemicals with Maternal Fatty Acids during Pregnancy and the Birth Weight of their Offspring: The Hokkaido Study.  [通常講演]

  フーマン グーダルズィ

  27th conference for International Society for Environmental Epidemiology, Sao Paulo, Brazil. 2015年09月 口頭発表（一般）
• Perinatal PFAAs exposure cause various health outcomes on offspring: the Hokkaido study.  [招待講演]

  フーマン グーダルズィ

  8th Copenhagen workshops on Endocrine Disruptors, Copenhagen, Denmark. 2015年04月 口頭発表（一般）
• Perinatal PFAAs Exposure Cause Various Health Outcomes on Offspring Including Effects on Reproductive and Thyroid Hormones: The Hokkaido Study.  [通常講演]

  フーマン グーダルズィ

  Pptox IV, Boston, USA. 2014年10月 口頭発表（一般）
• Exposure to perfluoroalkyl chemicals and neurodevelopment at 6 months of age.  [通常講演]

  フーマン グーダルズィ

  26th conference for International Society for Environmental Epidemiology, Seattle, USA. 2014年08月 ポスター発表
• The effects of perfluoroalkyl acids (PFAAs) exposure in utero on IGF2/H19 DNA methylation in cord blood.  [通常講演]

  フーマン グーダルズィ

  26th conference for International Society for Environmental Epidemiology, Seattle, USA. 2014年08月 口頭発表（一般）

その他活動・業績

• Childhood allergies and obesity relationship: Identification of novel non-invasive biomarkers

  Houman Goudarzi, Satoshi Konno, Atsuko Araki, Sachiko Ito, Yu Ait Bamai, Chihiro Miyashita, Reiko Kishi EUROPEAN RESPIRATORY JOURNAL 54 2019年09月
• 気道炎症・バイオマーカー 重症喘息患者における増悪状況とTh2マーカー陽性数の検討

  木村 孔一, 牧田 比呂仁, 谷口 菜津子, 木村 裕樹, 清水 薫子, 鈴木 雅, 武井 望, 松本 宗大, Goudarzi Houman, 西村 正治, 今野 哲 アレルギー 68 (4-5) 491 -491 2019年05月 [査読無し][通常論文]
  
• COPD患者における呼吸機能と気道内腔体積との関連

  小熊 昂, 清水 薫子, 牧田 比呂仁, 阿部 結希, 松本 宗大, 武井 望, 木村 孔一, 木村 裕樹, Goudarzi Houman, 鈴木 雅, 今野 哲, 西村 正治 日本呼吸器学会誌 8 (増刊) 246 -246 2019年03月 [査読無し][通常論文]
  
• 学童の尿中リン酸トリエステル類代謝物濃度と尿中炎症関連マーカーとの関連

  アイツバマイ ゆふ, Bastiaensen Michiel, 荒木 敦子, Houman Goudarzi, 今野 哲, 伊藤 佐智子, 宮下 ちひろ, Covaci Adrian, 岸 玲子 日本衛生学雑誌 74 (Suppl.) S116 -S116 2019年02月 [査読無し][通常論文]
  
• 学童の尿中リン酸トリエステル類代謝物濃度と尿中炎症関連マーカーとの関連

  アイツバマイ ゆふ, Bastiaensen Michiel, 荒木 敦子, Houman Goudarzi, 今野 哲, 伊藤 佐智子, 宮下 ちひろ, Covaci Adrian, 岸 玲子 日本衛生学雑誌 74 (Suppl.) S116 -S116 2019年02月 [査読無し][通常論文]
  
• 化学療法による腫瘍縮小後にエドキサバンが奏功した肺癌合併静脈血栓塞栓症の1例

  庄司 哲明, 水柿 秀紀, 池澤 靖元, 古田 恵, 高島 雄太, 菊池 創, Goudarzi Houman, 朝比奈 肇, 菊地 順子, 菊地 英毅, 榊原 純, 品川 尚文, 辻野 一三, 西村 正治 肺癌 57 (7) 914 -914 2017年12月 [査読無し][通常論文]
  
• 北海道大学における医学英語の取り組みと、学生の英語学習に対するモチベーションに関するアンケート調査

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• 妊娠初期における就労女性の有害物質の取扱いが児の流・死産に及ぼす影響

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受賞

• 2022年10月 Japanese Society for Allergology Best presentation award, the 71st Japanese Society for Allergology Annual Meeting
   

  受賞者: Houman Goudarzi
• 2021年07月 The Japan Society for Medical Education Gold Award for Academic Excellence, the 53rd Annual Meeting of the Japan Society for Medical Education
   

  受賞者: Houman Goudarzi
• 2020年03月 Hokkaido University 第39回（令和元年度）北海道大学大学院医学研究院・大学院医学院・医学部医学科高桑榮松奨学基金奨励賞
   

  受賞者: Houman Goudarzi
• 2018年08月 The International Society for Environmental Epidemiology Travel Award for the 28th conference of the International Society for Environmental Epidemiology (ISEE)
   28th conference of the International Society for Environmental Epidemiology (Rome, Italy, 2016). 

  受賞者: Houman Goudarzi
• 2017年08月 International Society for Environmental Epidemiology Travel award for 29th conference of the International Society for Environmental Epidemiology
   Travel award for 29th conference of the International Society for Environmental Epidemiology 

  受賞者: Houman Goudarzi
• 2017年06月 Japanese Society for Allergology Best presentation award, the 67th Japanese Society for Allergology Annual Meeting
   

  受賞者: Houman Goudarzi
• 2016年08月 Ito Zaidan Travel award for participation in the International Society for Environmental Epidemiology (ISEE), Rome, Italy.
   Ito Zaidan travel award for participation in the International Society for Environmental Epidemiology (ISEE), Rome, Italy. 

  受賞者: Houman Goudarzi
• 2015年08月 The International Society for Environmental Epidemiology (ISEE) (Sao Paulo, Brazil) Travel award for 27th conference of the International Society for Environmental Epidemiology
   Travel Award for the 27th conference of the International Society for Environmental Epidemiology (Sao Paulo, Brazil, 2015).
• 2014年08月 26th conference of the International Society for Environmental Epidemiology (ISEE) (Seattle, USA). Travel award for the 26th conference of the International Society for Environmental Epidemiology (Seattle, USA, 2014).
   Travel Award for the 26th conference of the International Society for Environmental Epidemiology (Seattle, USA, 2014). 

  受賞者: Houman Goudarzi

共同研究・競争的資金等の研究課題

• 環境化学物質曝露による有害作用：人疫学研究と動物実験による機序解明

  Ministry of Education, Culture, Sports, Science and Technology (MEXT)：Grant-in-Aid for Scientific Research (A) KIBAN A

  研究期間 : 2021年 -2024年
• Potential role of club cell secretory protein (CC16) in development of obese asthma: findings from a large-scale prospective birth cohort and animal studies

  The Front Office of Human Resource Education and Development (FOHRED), Hokkaido University：Support for the Collaborative Research of Next-Generation Researchers

  研究期間 : 2021年 -2022年
• Multi-disciplinary Educational and Scientific Seminar Series in English

  The Front Office of Human Resource Education and Development (FOHRED), Hokkaido University：Financial Support Systems for Young Researchers: Support for convening an international research meeting

  研究期間 : 2021年 -2022年
• Potential role of club cell secretory protein (CC16) in development of obese asthma: Findings from a birth cohort and animal studies

  Ministry of Education, Culture, Sports, Science and Technology (MEXT)：Grant-in-Aid for Scientific Research (C) KIBAN C

  研究期間 : 2020年 -2022年
• Multi-disciplinary Educational and Scientific Seminar Series in English

  The Front Office of Human Resource Education and Development (FOHRED), Hokkaido University：Financial Support Systems for Young Researchers: Support for convening an international research meeting

  研究期間 : 2020年 -2021年
• Potential role of club cell secretory protein (CC16) in obese asthma patients

  The Front Office of Human Resource Education and Development (FOHRED), Hokkaido University：Financial Support Systems for Young Researchers: Support for international research collaboration

  研究期間 : 2020年 -2021年
• 気管支喘息とCOPDの合併病態に焦点を当てた慢性気道疾患患者の包括的前向き コホート研究 (PIRICA study)

  Global Novartis：Global Novartis Research Support

  研究期間 : 2017年 -2021年 

  代表者 : Department Of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine
• 環境研究総合推進費 (研究分担者)、 環境省、 日本

  研究期間 : 2017年04月 -2019年05月 

  代表者 : フーマン グーダルズィ
• Creative Research Institution Sousei, Office for Developing Future Research Leaders (L-Station)

  Hokkaido University：Creative Research Institution Sousei, Office for Developing Future Research Leaders (L-Station)

  研究期間 : 2018年04月 -2019年03月 

  代表者 : Houman Goudarzi
• Grant-in-Aid for Young Scientists B (若手B) as Principal Investigator, JSPS, Japan

  研究期間 : 2017年04月 -2019年03月 

  代表者 : フーマン グーダルズィ
• Identification of non-invasive novel biomarkers predicting future asthma exacerbations in adults and early-onset wheeze in children

  Ministry of Education, Culture, Sports, Science and Technology (MEXT)：Grant-in-Aid for Young Scientists B (WAKATE B)

  研究期間 : 2017年 -2019年
• 環境化学物質の複合曝露による 喘息・アレルギー、免疫系へ及ぼす影響の解明

  Ministry of the Environment (環境省)：Grant from Ministry of the Environment: 環境研究総合推進費

  研究期間 : 2017年 -2019年
• 環境研究総合推進費 (研究分担者)、 環境省、 日本

  研究期間 : 2014年04月 -2017年03月 

  代表者 : フーマン グーダルズィ
• Grant-in-Aid for JSPS fellow（日本学術振興会 外国人特別研究員）Japan Society for the Promotion of Science

  研究期間 : 2014年10月 -2016年03月 

  代表者 : フーマン グーダルズィ
• Challenging Exploratory Research (挑戦的萌芽研究, 研究分担者), JSPS, Japan

  研究期間 : 2014年04月 -2016年03月 

  代表者 : フーマン グーダルズィ
• Grant-in-Aid for Young Scientists B (若手B) as Principal Investigator, JSPS, Japan (2014)

  研究期間 : 2014年04月 -2014年10月 

  代表者 : フーマン グーダルズィ
• Grant-in-Aid for Research Activity Start-up (研究活動スタート支援) as Principal Investigator, JSPS, Japan (2013)

  研究期間 : 2013年04月 -2014年03月 

  代表者 : フーマン グーダルズィ

教育活動情報

主要な担当授業