研究者データベース
| 木村 尚史(キムラ タカシ) |
| 医学研究院 社会医学系部門 社会医学分野 |
| 助教 |
Last Updated :2023/12/06
研究活動情報
論文
- Akinori Yaegashi, Takashi Kimura, Kenji Wakai, Hiroyasu Iso, Akiko TamakoshiJournal of epidemiology 2023年11月18日 [査読有り][通常論文]
BACKGROUND: We prospectively examined the association between total fat and fatty acid intake and type 2 diabetes (T2D) among Japanese adults. METHODS: This study was conducted using data from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC). A validated food frequency questionnaire evaluated the intake of total fat and fatty acids. Diabetes was assessed using self-reported data. Multivariable logistic regression analysis was performed to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) of incident T2D across quintiles of total fat and fatty acid intake after adjusting for potential confounders. RESULTS: A total of 19,088 non-diabetic participants (age range, 40-79 years) enrolled in the JACC between 1988 and 1990 were included in this study. During the five-year study period, 494 the participants developed T2D. The OR of T2D for the highest versus lowest quintiles was 0.58 (95% CI, 0.37-0.90) for total fat, 0.78 (95% CI, 0.51-1.20) for saturated fatty acid (SFA), 0.55 (95% CI, 0.35-0.86) for monounsaturated fatty acids (MUFA), 0.61 (95% CI, 0.39-0.96) for polyunsaturated fatty acids (PUFA), 0.64 (95% CI, 0.42-0.99) for n-3 PUFA, and 0.70 (95% CI, 0.45-1.09) for n-6 PUFA. Total fat and fatty acid (except SFA and n-6 PUFA) intake were inversely associated with T2D in men. Total fat and fatty acid intake were not associated with T2D in women. CONCLUSION: Higher intakes of total fats, MUFA, PUFA, and n-3 PUFA were inversely associated with T2D among Japanese men. - Isao Oze, Hidemi Ito, Yuriko N Koyanagi, Sarah Krull Abe, Md Shafiur Rahman, Md Rashedul Islam, Eiko Saito, Prakash C Gupta, Norie Sawada, Akiko Tamakoshi, Xiao-Ou Shu, Ritsu Sakata, Reza Malekzadeh, Ichiro Tsuji, Jeongseon Kim, Chisato Nagata, San-Lin You, Sue K Park, Jian-Min Yuan, Myung-Hee Shin, Sun-Seog Kweon, Mangesh S Pednekar, Shoichiro Tsugane, Takashi Kimura, Yu-Tang Gao, Hui Cai, Akram Pourshams, Yukai Lu, Seiki Kanemura, Keiko Wada, Yumi Sugawara, Chien-Jen Chen, Yu Chen, Aesun Shin, Renwei Wang, Yoon-Ok Ahn, Min-Ho Shin, Habibul Ahsan, Paolo Boffetta, Kee Seng Chia, You-Lin Qiao, Nathaniel Rothman, Wei Zheng, Manami Inoue, Daehee Kang, Keitaro MatsuoInternational journal of cancer 2023年11月15日 [査読有り][通常論文]
Body fatness is considered a probable risk factor for biliary tract cancer (BTC), whereas cholelithiasis is an established factor. Nevertheless, although obesity is an established risk factor for cholelithiasis, previous studies of the association of body mass index (BMI) and BTC did not take the effect of cholelithiasis fully into account. To better understand the effect of BMI on BTC, we conducted a pooled analysis using population-based cohort studies in Asians. In total, 905 530 subjects from 21 cohort studies participating in the Asia Cohort Consortium were included. BMI was categorized into four groups: underweight (<18.5 kg/m2 ); normal (18.5-22.9 kg/m2 ); overweight (23-24.9 kg/m2 ); and obese (25+ kg/m2 ). The association between BMI and BTC incidence and mortality was assessed using hazard ratios (HR) and 95% confidence intervals (CIs) by Cox regression models with shared frailty. Mediation analysis was used to decompose the association into a direct and an indirect (mediated) effect. Compared to normal BMI, high BMI was associated with BTC mortality (HR 1.19 [CI 1.02-1.38] for males, HR 1.30 [1.14-1.49] for females). Cholelithiasis had significant interaction with BMI on BTC risk. BMI was associated with BTC risk directly and through cholelithiasis in females, whereas the association was unclear in males. When cholelithiasis was present, BMI was not associated with BTC death in either males or females. BMI was associated with BTC death among females without cholelithiasis. This study suggests BMI is associated with BTC mortality in Asians. Cholelithiasis appears to contribute to the association; and moreover, obesity appears to increase BTC risk without cholelithiasis. - Jae Jeong Yang, Wanqing Wen, Hana Zahed, Wei Zheng, Qing Lan, Sarah K Abe, Md Shafiur Rahman, Md Rashedul Islam, Eiko Saito, Prakash C Gupta, Akiko Tamakoshi, Woon-Puay Koh, Yu-Tang Gao, Ritsu Sakata, Ichiro Tsuji, Reza Malekzadeh, Yumi Sugawara, Jeongseon Kim, Hidemi Ito, Chisato Nagata, San-Lin You, Sue K Park, Jian-Min Yuan, Myung-Hee Shin, Sun-Seog Kweon, Sang-Wook Yi, Mangesh S Pednekar, Takashi Kimura, Hui Cai, Yukai Lu, Arash Etemadi, Seiki Kanemura, Keiko Wada, Chien-Jen Chen, Aesun Shin, Renwei Wang, Yoon-Ok Ahn, Min-Ho Shin, Heechoul Ohrr, Mahdi Sheikh, Batel Blechter, Habibul Ahsan, Paolo Boffetta, Kee Seng Chia, Keitaro Matsuo, You-Lin Qiao, Nathaniel Rothman, Manami Inoue, Daehee Kang, Hilary A Robbins, Xiao-Ou ShuJournal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2023年11月07日 [査読有り][通常論文]
OBJECTIVES: Although lung cancer prediction models are widely used to support risk-based screening, their performance outside Western populations remains uncertain. This study aims to evaluate the performance of 11 existing risk prediction models in multiple Asian populations and to re-fit prediction models for Asians. METHODS: In a pooled analysis of 186,458 Asian ever-smokers from 19 prospective cohorts, we assessed calibration (expected to observed ratios, E/O) and discrimination (area under the receiver operating characteristic curves, AUCs) for each model. In addition, we developed the 'Shanghai models' to better refine risk models for Asians based on two well-characterized population-based prospective cohorts and externally validated them in other Asian cohorts. RESULTS: Among 11 models, the Lung Cancer Death Risk Assessment Tool yielded the highest AUC (AUC [95% CI]=0.71 [0.67-0.74] for lung cancer death and 0.69 [0.67-0.72] for lung cancer incidence), and the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial Model showed good calibration overall (E/O [95% CI]=1.06 [0.90-1.25]). However, these models substantially underestimated lung cancer risk among Asians who reported less than 10 smoking pack-years or stopped smoking ≥20 years ago. The Shanghai models showed marginal improvement overall in discrimination (AUC [95% CI]=0.72 [0.69-0.74] for lung cancer death and 0.70 [0.67-0.72] for lung cancer incidence) but consistently outperformed the selected Western models among low-intensity smokers and long-term quitters. CONCLUSIONS: The Shanghai models had comparable performance overall to the best existing models, but they improved much in predicting the lung cancer risk of low-intensity smokers and long-term quitters in Asia. - Wen Hao, Yi-Fan Shan, Takashi Kimura, Shigekazu Ukawa, Hideki Ohira, Satoe Okabayashi, Kenji Wakai, Masahiko Ando, Akiko TamakoshiArchives of gerontology and geriatrics 117 105254 - 105254 2023年10月31日 [査読有り][通常論文]
OBJECTIVES: Dual decline in gait speed and cognition has been found to have higher dementia risk than no decline or pure decline. However, evidence from the Asian population is lacking. Therefore, we aimed to investigate the association of dual decline from age 65 to 70 years with late-life dementia in older Japanese adults with different personal characteristics. METHODS: Data were collected from an age-specific cohort study conducted in 482 Japanese 65-year-old adults. We investigated participant demographics, medical histories, lifestyles, subjective gait speed, and cognition at both 64/65 and 70/71 years old, and confirmed dementia until age of 85 years. Cox proportion hazard models were used to estimate the risk of dementia, with adjustments for covariates, and death was treated as a competing risk. RESULTS: After a mean follow-up period of 12.5-years, 111 participants developed dementia. Older adults with dual decline are more likely to have hyperlipidemia, diabetes, and smoking habits. And we found that dual decline in gait speed and domain-specific cognition was associated with a higher risk of dementia compared with no decline in most cognitive tests, with the highest risk observed for gait speed combined with memory (sub-distribution hazard ratio:3.89, 95 %, confidence intervals: [1.68-9.01]). However, significant differences only existed in men after stratification by sex. CONCLUSIONS: A dual decline in subjective gait speed and cognition may serve as a robust predictor of dementia over a decade prior to its onset, particularly in men. These findings highlighted the importance of screening for dual decline at an early age. - Akinori Yaegashi, Satoshi Sunohara, Takashi Kimura, Wen Hao, Takato Moriguchi, Akiko TamakoshiDiabetology international 14 4 327 - 338 2023年10月 [査読有り][通常論文]
BACKGROUND: Previous meta-analyses have assessed the relationship between carbohydrate intake and type 2 diabetes (T2D) risk; however, they included few studies of Asian populations who have a higher carbohydrate intake and lower insulin secretory capacity than non-Asians. Since the publication of the previous meta-analyses, three further studies of Asian populations have been conducted. Based on this background, the present study aimed to perform an updated systematically examine observational studies concerning the link between dietary carbohydrate intake and T2D risk. METHODS: We conducted a systematic search for cohort studies that investigated the target association. For each analyzed study, parameter-adjusted risk ratios were used to compare the lowest and highest carbohydrate-intake groups in terms of their risk of incident T2D. The risk ratios were calculated using a random-effects model. RESULTS: Ten publications were analyzed. Overall, carbohydrate intake was found not to be associated with increased risk ratios of incident T2D (risk ratio [RR] = 1.07; 95% confidence interval [95% CI] = 0.94, 1.21; P < 0.01, I2 = 61.9%). However, studies of Asian populations reported that high carbohydrate intake is significantly associated with this risk (RR = 1.29; 95% CI 1.15, 1.45; P = 0.59, I2 = 0.0%). CONCLUSIONS: This updated meta-analysis showed that, overall, carbohydrate intake is not associated with the risk of T2D; nevertheless, a significant association exists among Asian populations. To confirm the association between dietary carbohydrate intake and T2D risk observed in this study, further evidence from long-term observational studies of Asian populations is required. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13340-023-00642-0. - Ryoko Katagiri, Motoki Iwasaki, Sarah Krull Abe, Md Rashedul Islam, Md Shafiur Rahman, Eiko Saito, Melissa A Merritt, Ji-Yeob Choi, Aesun Shin, Norie Sawada, Akiko Tamakoshi, Woon-Puay Koh, Ritsu Sakata, Ichiro Tsuji, Jeongseon Kim, Chisato Nagata, Sue K Park, Sun-Seog Kweon, Xiao-Ou Shu, Yu-Tang Gao, Shoichiro Tsugane, Takashi Kimura, Jian-Min Yuan, Seiki Kanemura, Yukai Lu, Yumi Sugawara, Keiko Wada, Min-Ho Shin, Habibul Ahsan, Paolo Boffetta, Kee Seng Chia, Keitaro Matsuo, You-Lin Qiao, Nathaniel Rothman, Wei Zheng, Manami Inoue, Daehee KangJAMA network open 6 9 e2332296 2023年09月05日 [査読有り][通常論文]
IMPORTANCE: Despite evidence of an association between reproductive factors and endometrial cancer risk, prospective studies have been conducted mainly in non-Asian countries. OBJECTIVE: To assess the association between reproductive factors, such as number of deliveries, age at menarche, or menopause, and endometrial cancer risk. DESIGN, SETTING, AND PARTICIPANTS: This cohort study used pooled individual data from 13 prospective cohort studies conducted between 1963 and 2014 in the Asia Cohort Consortium. Participants were Asian women. Data analysis was conducted from September 2019 to April 2023. EXPOSURES: Reproductive factors were assessed using a questionnaire in each cohort. MAIN OUTCOMES AND MEASURES: The main outcome was time to incidence of endometrial cancer. A Cox proportional hazards model was used to calculate hazard ratios (HRs) and 95% CIs. RESULTS: A total of 1005 endometrial cancer cases were detected among 332 625 women (mean [SD] age, 54.3 [10.4] years) during a mean (SD) of 16.5 (6.4) years of follow-up. Increasing number of deliveries was associated with a decreased endometrial cancer risk in a dose-response manner (≥5 deliveries vs nulliparous [reference]: HR, 0.37; 95% CI, 0.26-0.53; P for trend < .001). Compared with menarche at younger than 13 years, menarche at 17 years or older had an HR of 0.64 (95% CI, 0.48-0.86; P for trend < .001). Late menopause (age ≥55 years) showed an HR of 2.84 (95% CI, 1.78-4.55; P for trend < .001) compared with the youngest age category for menopause (<45 years). Age at first delivery, hormone therapy, and breastfeeding were not associated with endometrial cancer risk. CONCLUSIONS AND RELEVANCE: This large pooled study of individual participant data found that late menarche, early menopause, and a higher number of deliveries were significantly associated with a lower risk of endometrial cancer. These convincing results from Asian prospective studies add to the growing body of evidence for the association between reproductive factors and endometrial cancer. - Yifan Shan, Wenjing Zhao, Wen Hao, Takashi Kimura, Shigekazu Ukawa, Hideki Ohira, Takashi Kawamura, Kenji Wakai, Masahiko Ando, Akiko Tamakoshi, Chengzeng WangArchives of gerontology and geriatrics 116 105163 - 105163 2023年08月20日 [査読有り][通常論文]
OBJECTIVES: To examine the effects of changes in individual/multiple social activities between 65 and 70 years of age on incident long-term care (LTC) needs between 70 and 80 in older adults with depressive symptoms. METHODS: Participants were recruited from the New Integrated Suburban Seniority Investigation Project, an ongoing prospective cohort study. A total of 525 older adults with depressive symptoms were included. The validated 15-item Geriatric Depression Scale was used to assess depressive symptoms. A self-report questionnaire was used to measure social activities (social-related, learning, and personal). LTC needs was defined according to Japan's Long-term Care Insurance System. A competing risk model and a Laplace regression model were used to estimate the hazard ratios of LTC needs incidence and the 25th percentile difference in LTC-needs-free survival time and their 95% confidence intervals. RESULTS: Out of 4314 person-years of mild LTC needs, 108 individuals developed it. Participants who increased their frequency of learning activities have a lower risk of developing mild LTC needs. Increasing the frequency could also prolong LTC-needs-free survival time by approximately 2.61 years. Out of 4535 person-years for severe LTC needs, 54 individuals developed it. Participants with a continuous regular frequency of learning activities had a lower risk of developing severe LTC needs. However, the association between this frequency and LTC-needs-free survival time for severe LTC needs was insignificant in the multivariable models. CONCLUSIONS: Increased frequency of learning activities reduced the risk of LTC needs among older adults with depressive symptoms and prolonged their LTC-needs-free survival time. - Junji Miyazaki, Satoyo Ikehara, Kanami Tanigawa, Takashi Kimura, Kimiko Ueda, Keiichi Ozono, Tadashi Kimura, Yayoi Kobayashi, Shin Yamazaki, Michihiro Kamijima, Tomotaka Sobue, Hiroyasu IsoEnvironment international 179 108123 - 108123 2023年08月05日 [査読有り][通常論文]
BACKGROUND: Prenatal exposure to metallic elements may adversely affect early childhood health. However, more evidence is needed as population-based cohort studies are currently limited. OBJECTIVES: We aimed to examine the associations between prenatal metallic (mercury, selenium, and manganese) exposure and the risk of allergic diseases in early childhood until three years of age. METHODS: The data from 94,794 mother-infant pairs, who participated in the Japan Environment and Children's study, were used in this study. Prenatal metallic element exposure was measured in maternal blood collected during mid-pregnancy. The incidence of atopic dermatitis, food allergies, asthma, and allergic rhinitis during the first three years of life was prospectively investigated using self-reports of physician-diagnosed allergies. A multivariable modified Poisson regression model was used to estimate the cumulative incidence ratio and their 95% confidence intervals of allergic diseases associated with prenatal exposure to mercury, selenium, and manganese. We further evaluated the interaction between mercury and selenium exposures in this association. RESULTS: We confirmed 26,238 cases of childhood allergic diseases: atopic dermatitis, food allergies, asthma, and allergic rhinitis in 9,715 (10.3%), 10,897 (11.5%), and 9,857 (10.4%), 4,630 (4.9%), respectively. No association was found between prenatal mercury or manganese exposure and the risk of allergic diseases. Prenatal selenium exposure was inversely associated with atopic dermatitis, food allergies, allergic rhinitis, and any allergic diseases, but not with asthma. These inverse associations were more pronounced for lower mercury exposures than for higher exposures. CONCLUSIONS: Our findings suggest that prenatal exposure to selenium may be beneficial for reducing the risk of atopic dermatitis, food allergies, allergic rhinitis, and any allergic diseases in early childhood, especially with lower prenatal mercury exposure. - Keiko Yamada, Takashi Kimura, Meishan Cui, Eizaburo Tanaka, Yasuhiko Kubota, Satoyo Ikehara, Hiroyasu IsoScientific reports 13 1 6068 - 6068 2023年04月13日 [査読有り]
The aim of cross-sectional study was to investigate whether the presence of autistic traits in pregnant women was positively associated with the prevalence and severity of antenatal pain. We analyzed 89,068 pregnant women from a Japanese national birth cohort cross-sectionally. Autistic traits were assessed using the Japanese version of the Autism-Spectrum Quotient short form (AQ-10-J). Antenatal pain was measured using the SF-8 bodily pain item (SF-8-Pain). Antenatal pain in the second to third trimester during pregnancy was categorized into three groups: without pain, mild pain, and moderate-to-severe pain. Participants were divided into eight groups by AQ-10-J score: seven consecutive scoring groups (scores 0-6), and those above the cut-off (≥ 7) for probable autistic spectrum disorders. Odds ratios (OR) for the prevalence of mild and moderate-to-severe pain were calculated for each AQ-10-J scoring group (reference: without pain group) using multinominal logistic regression analysis. Autistic traits were positively associated with mild and moderate-to-severe pain in a dose-response manner, but the association with moderate-to-severe pain was strongest. Fully-adjusted ORs (95% confidence intervals) for moderate-to-severe pain were: 1.01 (0.91-1.13) for 1 point, 1.13 (1.02-1.25) for 2 points, 1.16 (1.04-1.29) for 3 points, 1.20 (1.07-1.34) for 4 points, 1.23 (1.09-1.40) for 5 points, 1.27 (1.10-1.47) for 6 points, and 1.24 (1.05-1.46) for ≥ 7 points (AQ-10-J cut-off). We identified an association between maternal autistic traits and antenatal pain. Maternal autistic traits may need to be considered when addressing antenatal pain during healthcare for expectant mothers. - Toshiaki Asakura, Takashi Kimura, Isaku Kurotori, Katabami Kenichi, Miyuki Hori, Mariko Hosogawa, Masayuki Saijo, Kaori Nakanishi, Hiroyasu Iso, Akiko TamakoshiEmerging infectious diseases 29 5 956 - 966 2023年04月12日 [査読有り]
We conducted a cross-sectional survey among SARS-CoV-2-positive persons and negative controls in Sapporo, Japan, to clarify symptoms of long COVID. We collected responses from 8,018 participants, 3,694 case-patients and 3,672 controls. We calculated symptom prevalence for case-patients at 2-3, 4-6, 7-9, 10-12, and 13-18 months after illness onset. We used logistic regression, adjusted for age and sex, to estimate the odds ratio (OR) for each symptom and control reference. We calculated symptom prevalence by stratifying for disease severity, age, and sex. At 4-18 months from illness onset, ORs for anosmia, ageusia, dyspnea, alopecia, and brain fog were consistently >1, whereas ORs for common cold-like, gastrointestinal, and dermatologic symptoms were <1. Time trend ORs increased for diminished ability to concentrate, brain fog, sleep disturbance, eye symptoms, and tinnitus. Clinicians should focus on systemic, respiratory, and neuropsychiatric symptoms among long COVID patients. - Daichi Watanuki, Akiko Tamakoshi, Takashi Kimura, Toshiaki Asakura, Masayuki SaijoJournal of epidemiology 2023年04月08日 [査読有り]
BACKGROUND: For therapeutic efficacy, molnupiravir and nirmatrelvir-ritonavir must be started to treat patients within 5 days of disease onset to treat patients with COVID-19. However, some patients spend more than 5 days from disease onset before reporting to the Public Health Office. This study aimed to clarify the characteristics of patients with reporting delay. METHODS: This study included data from 12,399 patients with COVID-19 who reported to the Public Health Office from March 3rd, 2021 to June 30th, 2021. Patients were stratified into "linked" (n=7,814) and "unlinked" (n=4,585) cases depending on whether they were linked to other patients. A long reporting delay was defined as the difference between the onset and reporting dates of 5 days or more. Univariate and multivariate analyses were performed using log-binomial regression to identify factors related to long reporting delay, and prevalence ratios with corresponding 95% confidence intervals were calculated. RESULTS: The proportion of long reporting delay was 24.4% (1904/7814) and 29.3% (1344/4585) in linked and unlinked cases, respectively. Risks of long reporting delay among linked cases were living alone and onset on the day with a higher 7-day daily average confirmed cases or onset on weekends; whereas, risks for unlinked cases were age over 65 years, without occupation and living alone. CONCLUSION: Our results suggest the necessity to establish a Public Health Office system that is less susceptible to the rapid increase in the number of patients, promotes educational activities for people with fewer social connections, and improves access to health care. - Kaki Tanaka, Emiko Okada, Takumi Hirata, Takashi Kimura, Akiko Tamakoshi[Nihon koshu eisei zasshi] Japanese journal of public health 70 6 359 - 368 2023年03月10日 [査読有り][通常論文]
Objectives Bonding failure is lack of parental emotional relationship between a parent and their infant. This study aims to investigate the association between father's involvements with their partner during pregnancy.Methods A total of 1,957 partners of pregnant women who had visited three maternity hospitals in Sapporo from May 2016 to December 2017 were included in the study. Self-administered questionnaires were distributed to participants at 2,435 weeks gestation and at 6-8 weeks postpartum. The fathers who responded to both the questionnaires were included in the analysis. The participants' relationship with their partners during pregnancy was rated using two questions- whether they help their partner with personal care and household chores, and whether they consult with their partner. Answers for both questions were given on a scale of 0 to 4. A total score of 6-8 points was defined as a high-score group, 3-5 points as a mid-score group, and 0-2 points as a low-score group. Bonding failure was evaluated using the Japanese version of the Mother-Infant Bonding Scale (MIBS-J). The cut-off value was the score that included the top 10% with the highest degree of bonding disorder. A logistic regression was used to analyse the association between involvement with a partner during pregnancy and bonding failure. The confounding variables were father's age, household income, father's average working hours, previous pregnancy, history of abortion/a stillbirth/the death of the child, and partner's prepartum depression during pregnancy.Results 391 fathers responded to the initial questionnaire, and 86.4% of them filled out the second questionnaire up to 2 months postpartum, 10.6% up to 3 months, 2.5% up to 4 months, and 1.0% up to 5 months. Of these, 375 were included, excluding those with missing questionnaire items. 255 fathers were in the high score group of the involvement with partner during pregnancy, 48 had bonding failure, 35 had LA, and 17 had AR. The OR based on the high score group of involvement with partner during pregnancy for bonding failure was 4.81 (1.88-12.33) for mid-score group, and 6.89 (1.40-33.93) for low-score group, and for LA, 2.21 (0.97-5.04) for mid-score group, and 6.40 (1.54-26.68) for low-score group; however, AR showed no respectively significant association (trend P 0.0005, 0.0053, 0.6859).Conclusions The results suggest that a father's unfavorable involvement with his partner affects the bonding with their infant. This suggests that involvement with a partner during pregnancy is an important factor in preventing bonding failure in fathers. - Yoko Yamagiwa, Keitaro Tanaka, Keitaro Matsuo, Keiko Wada, Yingsong Lin, Yumi Sugawara, Tetsuya Mizoue, Norie Sawada, Hidemi Takimoto, Hidemi Ito, Tetsuhisa Kitamura, Ritsu Sakata, Takashi Kimura, Shiori Tanaka, Manami InoueScientific reports 13 1 3445 - 3445 2023年03月01日 [査読有り][通常論文]
In Japan, hepatocellular carcinoma (HCC) is a leading cause of cancer mortality and hepatitis C virus infection is a major cause of HCC. We conducted a systematic review and meta-analysis of published studies evaluating patient response to antiviral therapy for chronic hepatitis C on the risk of HCC occurrence in Japan. Articles were searched using terms determined a priori through PubMed, screened by title and abstract, and selected by full-text assessment according to criteria determined a priori, including HCC occurrence in response to interferon (IFN)-based or IFN-free therapy, Japanese study, and 2 or more years of follow-up. We excluded studies on HCC recurrence. We calculated the pooled estimate of the crude incidence rate ratio with data from the selected studies using the person-years method with Poisson regression model and pooled estimate of the hazard ratio adjusted for potential confounders reported by the studies using a random effects model. A total of 26 studies were identified, all of which examined only IFN-based therapy as a result of the selection process. The pooled estimate (95% confidence interval [CI]) of 25 studies was 0.37 (0.33-0.43) for sustained virologic response (SVR) and 1.70 (1.61-1.80) for non-SVR for the HCC incidence rate per 100 person-years, and 0.22 (0.19-0.26) for the incidence rate ratio (SVR vs. non-SVR). The pooled estimate of the hazard ratio (95% CI) of HCC incidence adjusted for potential confounders of 8 studies was 0.25 (0.19-0.34). SVR to interferon therapy for chronic hepatitis C reduces the risk of HCC occurrence. - Rachana Manandhar Shrestha, Tetsuya Mizoue, Zobida Islam, Yukino Kawakatsu, Hidemi Ito, Keiko Wada, Chisato Nagata, Ling Zha, Tetsuhisa Kitamura, Ritsu Sakata, Takashi Kimura, Yumi Sugawara, Ichiro Tsuji, Ren Sato, Norie Sawada, Shoichiro Tsugane, Yingsong Lin, Isao Oze, Sarah Krull Abe, Manami InoueJournal of epidemiology 2023年02月25日 [査読有り][通常論文]
BACKGROUND: While tall stature has been linked to an increase in the risk of colorectal cancer (CRC), its association with cancer in the colorectum and its subsites remains unclear among Asians. METHODS: We conducted a pooled analysis of ten population-based cohort studies among adults in Japan. Each study estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for CRC incidence associated with adult height were estimated using Cox proportional hazards regression with adjustment of the same set of covariates were then pooled to estimate summary HRs incidence using random-effect models. RESULTS: We identified 9,470 CRC incidences among 390,063 participants during 5,672,930 person-years of follow-up. Men and women with tall stature had a higher risk of CRC and colon cancer. HRs (95% CI) for CRC, colon cancer, and distal colon cancer (DCC) for the highest versus lowest height categories were 1.23 (1.07-1.40), 1.22 (1.09-1.36), and 1.27 (1.08-1.49), respectively, in men and 1.21 (1.09-1.35), 1.23 (1.08-1.40), and 1.35 (1.003-1.81), respectively, in women. The association with proximal colon cancer (PCC) and rectal cancer was less evident in both sexes. CONCLUSIONS: This pooled analysis confirms the link between tall stature and a higher risk of CRC and colon cancer (especially distal colon) among the Japanese and adds evidence to support the use of adult height to identify those at a higher risk of CRC. - Yosuke Komatsu, Yasuaki Wada, Fuka Tabata, Satomi Kawakami, Yasuhiro Takeda, Kiminori Nakamura, Tokiyoshi Ayabe, Koshi Nakamura, Takashi Kimura, Akiko TamakoshiNutrients 15 3 2023年01月28日 [査読有り][通常論文]
Maternal diet may affect human milk macronutrients, but it remains to be elucidated whether this is also influential in infant growth. This study aimed to examine (1) how maternal diet influences human milk macronutrients, and (2) to what extent the variation in milk macronutrients affects infant growth during the first month of life. In 71 Japanese lactating women, maternal dietary information was collected from the brief-type self-administered diet history questionnaire, and anthropometry of mother-infant dyads was collected from medical records. Macronutrients in milk were analyzed by a Human Milk Analyzer. Maternal retinol intake was associated with the carbohydrate content in human milk at 1-month postpartum (standardized β coefficient: 0.287; p = 0.038). Moreover, the energy content in human milk was associated with an increase in the weight standard deviation score based on the WHO growth standard at 1 month of age (standardized β coefficient: 0.399; p = 0.046). Nevertheless, the milk macronutrient was not associated with the risk of infant growth abnormalities. In conclusion, a part of the maternal diet impacts macronutrient contents in human milk, but milk macronutrients have a limited effect on infant growth only within the normal growth curve during the first month of life. - Kenichi Katabami, Takashi Kimura, Takumi Hirata, Akiko TamakoshiJournal of epidemiology 2023年01月28日 [査読有り][通常論文]
BACKGROUND: The neurological prognosis of asphyxia is poor and the effect of advanced airway management (AAM) in the prehospital setting remains unclear. This study aimed to evaluate the association between AAM with adrenaline injection and prognosis in adult patients with asystole asphyxia out-of-hospital cardiac arrest (OHCA). METHODS: This study assessed all-Japan Utstein cohort registry data between January 1, 2013 and December 31, 2019. We used propensity score matching analyses before logistic regression analysis to evaluate the effect of AAM on favorable neurological outcome. RESULTS: There were 879,057 OHCA cases, including 70,299 cases of asphyxia OHCAs. We extracted the data of 13,642 cases provided with adrenaline injection by emergency medical service. We divided 7,945 asphyxia OHCA cases in asystole into 5,592 and 2,353 with and without AAM, respectively. After 1:1 propensity score matching, 2,338 asphyxia OHCA cases with AAM were matched with 2,338 cases without AAM. Favorable neurological outcome was not significantly different between the AAM and no AAM groups (adjusted odds ratio: 1.1, 95% confidence interval (CI): 0.5-2.5). However, the return of spontaneous circulation (ROSC) (adjusted odds ratio: 1.7, 95% CI: 1.5-1.9) and 1-month survival were improved in the AAM groups (adjusted odds ratio: 1.5, 95% CI: 1.1-1.9). CONCLUSIONS: AAM with adrenaline injection for patients with asphyxia OHCA in asystole was associated with improved ROSC and 1-month survival rate but showed no differences in neurologically favorable outcome. Further prospective studies may comprehensively evaluate the effect of AAM for patients with asphyxia. - Yoshihiro Saito, Toshiaki Asakura, Kimura Takashi, Takeshi Umazume, Hidemichi Watari, Akiko TamakoshiThe journal of obstetrics and gynaecology research 49 3 930 - 937 2023年01月05日 [査読有り][通常論文]
AIM: This study aimed to investigate the relationship between the distance and travel time from each municipality to the nearest delivery facilities in the other municipalities and the frequency of out-of-facility deliveries in Hokkaido. METHODS: Vital statistics from 2016 to 2020 were used. For municipalities without delivery facilities, the distance and travel time from the town office of each municipality to the nearest delivery facility was measured using Google maps. Negative binomial regression with an offset term was used to calculate the relative risks (RRs) and 95% confidence intervals (CIs) of out-of-facility delivery for distance (<30, 30-59, ≥60 km), and travel time by car (<30, 30-59, and ≥60 min) from the town office to the nearest delivery facility compared with the presence of delivery facilities. RESULTS: The overall rate of out-of-facility deliveries in Hokkaido was 2.1‰; in municipalities with delivery facilities, 1.8‰, and in municipalities without delivery facilities, 3.1‰. The adjusted RRs (95% CIs) for out-of-facility deliveries were significantly higher in municipalities with less than 30 km and travel time of less than 30 min to delivery facilities, 2.63 (1.34-5.17) and 2.76 (1.36-5.58), respectively, compared to municipalities with delivery facilities. However, the adjusted RR of out-of-facility delivery for municipalities ≥30 km was higher, although the difference was not significant. CONCLUSIONS: Even in municipalities with a distance to delivery facilities of less than 30 km or travel time of less than 30 min, we should keep in mind the occurrence of out-of-facility deliveries. - Akinori Yaegashi, Takashi Kimura, Takumi Hirata, Hiroyasu Iso, Akiko TamakoshiJournal of nutritional science 12 e50 2023年 [査読有り][通常論文]
We prospectively examined the association between low-carbohydrate diet (LCD) score and incidence of type 2 diabetes (T2D) in Japanese adults using Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study) data. A total of 19 084 (7052 men and 12 032 women) Japanese non-diabetic participants aged 40-79 years, who enrolled in the JACC study between 1988 and 1990, were included in our analysis. Dietary intake was evaluated using a validated food-frequency questionnaire. The overall, animal and vegetable LCD scores were calculated by dividing the study participants into eleven categories based on the percentages of energy from carbohydrates, protein and fat. The incidence of T2D was assessed using a self-administered questionnaire. We used multivariable logistic regression analysis to estimate the odds ratios (ORs) and 95 % confidence intervals (CIs) of incident T2D across the quintile of each LCD score, with adjustment for potential confounders. During the 5-year study period, 490 adults (247 men and 243 women) developed T2D. The multivariable-adjusted OR of incident T2D for the highest v. lowest quintiles of overall and animal LCD scores, respectively, were 0·64 (95 % CI 0·42, 0·99) and 0·83 (95 % CI 0·55, 1·27) for men, 0·78 (95 % CI 0·51, 1·18) and 0·84 (95 % CI 0·57, 1·24) for women. The vegetable LCD score was associated with a lower risk of T2D in men (OR 0·51; 95 % CI 0·33, 0·77). Our results suggest that diets lower in carbohydrates and higher in fat and protein are unlikely to higher the T2D risk among Japanese individuals. - Mina Hayama-Terada, Yuri Aochi, Satoyo Ikehara, Takashi Kimura, Kazumasa Yamagishi, Takuyo Sato, Hiroyasu IsoEnvironmental health and preventive medicine 28 12 - 12 2023年 [査読有り][通常論文]
BACKGROUND: Few prospective studies have investigated the association between paternal occupational exposures and risk of infant congenital heart defects (CHDs). We investigated the associations between paternal occupational exposures, frequency of use, and concurrent or sequential exposure to a mixture of compounds and the risk of infant CHDs. METHODS: Our study examined 28,866 participants in the Japan Environment and Children's Study. Logistic regression analysis was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) associated with paternal occupational exposures during the 3 months until pregnancy was noticed after adjustment for potential confounding factors of the infant CHDs. CHD diagnosis was ascertained from medical record. RESULTS: In total, 175 were diagnosed with infant CHDs. The number of fathers who were exposed to the following substances at least once a month were: 11,533 for photo copying machine/laser printer, 10,326 for permanent marker, 8,226 for soluble paint/inkjet printer, 6,188 for kerosene/petroleum/benzene/gasoline, 4,173 for organic solvents, 3,433 for chlorine bleach/germicide, 2,962 for engine oil, 2,931 for insecticide, 2,460 for medical sterilizing disinfectant, 1,786 for welding fumes, 1,614 for dyestuffs, 1,247 for any products containing lead-like solder, 986 for herbicide, 919 for radiation/radioactive substances/isotopes, 837 for lead-free solder, 341 for microbes, 319 for formalin/formaldehyde, 301 for agricultural chemical not listed above or unidentified, 196 for general anesthetic for surgery at hospital, 171 for anti-cancer drug, 147 for chromium/arsenic/cadmium, 88 for mercury and 833 for other chemical substances. Paternal occupational exposure regularly to photo copying machine or laser printer and soluble paint/inkjet printer were associated with higher risks of infant CHDs: the adjusted ORs (95%CIs) were 1.38 (1.00-1.91) and 1.60 (1.08-2.37), respectively. The higher risks were also observed for occasional exposure to engine oil, any products containing lead-like solder lead-free solder, and microbes; the adjusted ORs (95%CIs) were 1.68 (1.02-2.77), 2.03 (1.06-3.88), 3.45 (1.85-6.43), and 4.51, (1.63-12.49), respectively. CONCLUSIONS: Periconceptional paternal occupational exposure was associated with a higher risk of infant CHDs. Further studies using biomarkers of the association between paternal occupational exposure and infant CHDs are warranted. - Kazuhito Miura, Yutaka Watanabe, Haruhisa Baba, Kimiya Ozaki, Takae Matsushita, Miyako Kondoh, Kazutaka Okada, Shinji Nakaoka, Katsuhiko Ogasawara, Teppei Suzuki, Hiroshi Saito, Takashi Kimura, Akiko Tamakoshi, Yutaka YamazakiScientific reports 12 1 20347 - 20347 2022年11月27日 [査読有り][通常論文]
This study examined the association between coronavirus disease 2019 (COVID-19)-related stress, exercise habits, and oral health-related quality of life (OHRQoL) in a sample of 215 community-dwelling older adults in Japan (57 men, 158 women; Mage = 74.2 years, SD = 6.0). Data were collected during wellness checkups in October 2020 and included participants' demographic characteristics, measures of instrumental activities of daily living and depressive tendencies, number of teeth, oral hypofunction, OHRQoL, COVID-19-related stress, and exercise habits. Four mutually exclusive groups were created, using the presence or absence of COVID-19-related stress and lack of exercise habits as risk factors for poor OHRQoL (no COVID-19-related stress and no lack of exercise, COVID-19-related stress only, lack of exercise habits only, and both COVID-19-related stress and lack of exercise habits). Poisson regression with robust standard errors provided the prevalence ratio for poor OHRQoL. The presence of both COVID-19-related stress and lack of exercise habits (adjusted prevalence ratio: 2.20, 95% CI: 1.31- 3.69) was associated with poor OHRQoL. The results indicate that COVID-19-related stress and exercise habits should be considered when designing oral health and public health initiatives. - Hiroyuki Masaoka, Keitaro Matsuo, Isao Oze, Takashi Kimura, Akiko Tamakoshi, Yumi Sugawara, Ichiro Tsuji, Norie Sawada, Shoichiro Tsugane, Hidemi Ito, Keiko Wada, Chisato Nagata, Tetsuhisa Kitamura, Ling Zha, Ritsu Sakata, Kotaro Ozasa, Yingsong Lin, Tetsuya Mizoue, Keitaro Tanaka, Sarah Krull Abe, Manami InoueJournal of epidemiology 2022年10月29日 [査読有り]
BACKGROUND: Although cigarette smoking is an established risk factor for bladder cancer, assessment of smoking impact on bladder cancer in Asian populations has been hindered by few cohort studies conducted in Asian populations. We therefore investigated the risk of bladder cancer associated with smoking status, cumulative smoking intensity and smoking cessation in Japan. METHODS: We analyzed data for 157,295 men and 183,202 women in ten population-based cohort studies in Japan. The risk associated with smoking behaviors was estimated using Cox regression models within each study, and pooled hazard ratios (HR) and their 95% confidence intervals (CI) for the incidence of bladder cancer were calculated. RESULTS: During 4,729,073 person-years of follow up, 936 men and 325 women developed bladder cancer. In men, former smokers (HR 1.47; 95% CI, 1.18-1.82) and current smokers (HR 1.96; 95% CI, 1.62-2.38) had higher risk than never smokers. In women, current smokers had higher risk than never smokers (HR 2.35; 95% CI, 1.67-3.32). HRs in men linearly increased with increasing pack-years. Risk decreased with increasing years of smoking cessation in men with a significant dose-response trend. Former smokers with a duration of more than 10 years after smoking cessation had no significantly increased risk compared with never smokers (HR 1.26; 95% CI, 0.97-1.63). CONCLUSIONS: Data from a pooled analysis of ten population-based cohort studies in Japan clearly show an association between cigarette smoking and bladder cancer risk. The risk of smokers may approximate that of never smokers following cessation for many years. - Junji Miyazaki, Kokoro Shirai, Takashi Kimura, Satoyo Ikehara, Akiko Tamakoshi, Hiroyasu IsoBMJ open 12 10 e059725 2022年10月10日 [査読有り]
OBJECTIVES: To investigate whether having a purpose in life (Ikigai) is associated with risk of cardiovascular disease (CVD) mortality and whether the association varies by employment status. DESIGN: Prospective cohort study. SETTING: Residents in 45 municipalities, Japan. PARTICIPANTS: 29 517 men and 41 984 women aged 40-79 years, free of CVD and cancer at baseline from 1988 to 1990. PRIMARY OUTCOME MEASURES: CVD mortality. RESULTS: During the median follow-up of 19.1 years, 4680 deaths (2393 men and 2287 women) from total CVD were observed. Greater Ikigai was associated with a lower risk of CVD mortality, and the result was stronger for men than for women. Stratified by employment status, the inverse association was confined to unemployed persons. Among unemployed persons, the multivariable HRs of total CVD were higher for moderate and high versus low levels of Ikigai. Multivariable HRs (95% CIs) were 0.74 (0.57 to 0.97) and 0.69 (0.52 to 0.93), P for trend <0.044, respectively in men, and 0.78 (0.64 to 0.95) and 0.77 (0.61 to 0.97), P for trend=0.039 in women. No association was observed among the employed, including part-time workers, self-employed and homemakers for both men and women. Such an inverse association remained even after excluding early deaths within 5 years from the baseline survey. CONCLUSION: Higher levels of Ikigai were associated with a lower risk of CVD mortality, especially for unemployed men and women. - Kanami Tanigawa, Yoko Kawanishi, Satoyo Ikehara, Takashi Kimura, Kimiko Ueda, Tadashi Kimura, Keiichi Ozono, Hiroyasu IsoPediatric obesity 18 1 e12978 2022年09月14日 [査読有り]
BACKGROUND: It is unclear if gestational weight gain (GWG) increases the risk of children with overweight. OBJECTIVES: We examined the association between GWG and the risk of overweight in 3-year-old children in the Japanese nationwide birth cohort study. METHODS: Among 64 336 singleton births, we calculated the risk ratios (RRs) and 95% confidence intervals (95% CIs) of the association between GWG categories and children with overweight, following an adjustment of the confounding variables. RESULTS: GWG was positively associated with the risk of overweight among 3-year-old children. The multivariable RR (95% CI) was 1.21 (1.17-1.25) per 5 kg increase of the GWG. The multivariable RR (95% CI) for excessive GWG was 1.20 (1.12-1.28) and 1.27 (1.16-1.39) based on the modified Japanese and IOM criteria, respectively, compared to adequate GWG. The multivariable RR (95% CI) of overweight with children for inadequate versus adequate GWG was 0.83 (0.78-0.88) and 0.84 (0.79-0.89) based on the modified Japanese and IOM criteria, respectively. CONCLUSIONS: GWG was positively associated with a high risk of overweight at 3 years of age. The risk of offspring overweight was 20%-27% higher and 16%-17% lower with excessive GWG and inadequate GWG, respectively, compared to adequate GWG, based on the aforementioned criteria. - Yifan Shan, Wenjing Zhao, Wen Hao, Takashi Kimura, Shigekazu Ukawa, Hideki Ohira, Takashi Kawamura, Kenji Wakai, Masahiko Ando, Akiko TamakoshiArchives of gerontology and geriatrics 104 104800 - 104800 2022年09月05日 [査読有り]
OBJECTIVE: We aimed to explore the association between changes in social activities and the occurrence/persistence of depressive symptoms and investigate the difference in effect sizes among the types and combinations of social activities. METHODS: The study adopted a valid 15-item Geriatric Depression Scale to assess depressive symptoms in 2480 community-dwelling adults aged 64/65 years. Changes in social-related, learning, and personal activities were classified into four categories: continued low frequency (CLF), increased frequency (IF), decreased frequency (DF), and continued regular frequency (CRF)1. Relative ratios (RRs) and 95% confidence intervals (95% CI) were calculated using a modified Poisson regression model. RESULTS: Those without depressive symptoms at baseline and who engaged in social-related (RRIF = 0.56 (0.39, 0.81), RRCRF = 0.55 (0.41, 0.74)), learning (RRIF = 0.63 (0.44, 0.89), RRCRF = 0.62 (0.46, 0.85)), and personal activities (RRIF = 0.37 (0.24, 0.57), RRCRF = 0.41 (0.30, 0.56)) at IF or CRF were less likely to develop depressive symptoms. Those with depressive symptoms at baseline, engaging in personal activities at IF (RR=0.67 (0.51, 0.87)) and CRF (RR= 0.80 (0.65-1.00)) were less likely to have persistent depressive symptoms. Participation in all three activities consistently at a regular frequency was inversely associated with the occurrence/persistence of depressive symptoms. CONCLUSIONS: The effect of personal activities was more manifest in preventing depressive symptoms than the other two kinds, regardless of depressive symptoms at baseline. Regularly engaging in a combination of all three activities at baseline and follow-up was associated with the occurrence and persistence of depressive symptoms. - Shigekazu Ukawa, Wenjing Zhao, Satoe Okabayashi, Takashi Kimura, Masahiko Ando, Kenji Wakai, Kazuyo Tsushita, Takashi Kawamura, Akiko TamakoshiSleep medicine 100 190 - 195 2022年09月03日 [査読有り]
OBJECTIVE: This study aimed to investigate the association between daily sleep duration and incident dementia among physically and socially independent older people with/without diseases (hypertension, diabetes mellitus, cardiovascular diseases) in a Japanese age-specific cohort. METHODS: We carried out a prospective cohort study including 1954 (1006 men and 948 women) Japanese individuals aged 64/65 years. Information on daily sleep duration, medical status, demographics, and lifestyle characteristics was collected by a baseline questionnaire survey and health checkup (2000-2005). Dates of incident dementia were confirmed using the nationally standardized dementia scale proposed by the Ministry of Health, Labor, and Welfare. A competing risk model was used to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs) for incident dementia. We treated censored cases due to death as competing events. RESULTS: During a median of 15.6 years of follow-up, 260 participants reported incident dementia. Compared with participants without diseases and who slept 6-7.9 h/day, those with a shorter daily sleep duration of <6 h/day, presence of disease and shorter, moderate, or longer daily sleep duration ≥8 h/day had an increased risk of incident dementia (HR 1.73; 95% CI 1.04-2.88, HR 1.98; 95% CI 1.14-3.44, HR 1.44; 95% CI 1.03-2.00, and HR 2.09; 95% CI 1.41-3.09, respectively) with a significant interaction between the presence of diseases and sleep duration (p < 0.001). CONCLUSIONS: The present findings suggest that habitual sleep duration predicts future risk of dementia. - Saeka Takabayashi, Takumi Hirata, Wenjing Zhao, Takashi Kimura, Shigekazu Ukawa, Kazuyo Tsushita, Kenji Wakai, Takashi Kawamura, Masahiko Ando, Akiko TamakoshiGeriatrics & gerontology international 22 9 736 - 744 2022年09月 [査読有り]
AIM: Dietary diversity might reduce the risk of malnutrition, although it is also linked to obesity. We examined whether dietary diversity is associated with all-cause mortality in Japanese older adults based on their body mass index (BMI). METHODS: The current study included 2944 people aged 64-65 years who participated in the New Integrated Suburban Seniority Investigation (NISSIN) project from 1996 to 2005. Dietary diversity was measured using the Food Variety Score (FVS), which calculates the frequency of all food items consumed daily using a self-administered food frequency questionnaire. Participants were divided into tertiles according to their FVS (first: low, second: middle, third: high). Multivariate adjusted hazard ratios with 95% confidence intervals were calculated using the Cox proportional hazard regression model. For the stratified analysis, BMI was used to divide the participants into three groups - lean (BMI <20), normal (BMI 20-24.9) and overweight/obese (BMI ≥25). RESULTS: Overall, 454 (30.7%) men and 222 (15.2%) women died over a median follow-up period of 16.6 years. No significant association was observed between FVS and all-cause mortality. However, when grouped by BMI, for the participants in the lean group, the multivariate adjusted hazard ratios were 0.56 (95% confidence interval 0.32-0.96) for the middle FVS and 0.50 (95% confidence interval 0.25-1.02) for the high FVS, compared with the low FVS (P for trend = 0.059). In overweight/obese women, although not significant, total mortality was higher in the middle and high FVS. CONCLUSIONS: These findings show that dietary diversity should be promoted in lean older Japanese adults. Geriatr Gerontol Int 2022; 22: 736-744. - Yifan Shan, Wenjing Zhao, Wen Hao, Takashi Kimura, Shigekazu Ukawa, Hideki Ohira, Takashi Kawamura, Kenji Wakai, Masahiko Ando, Akiko TamakoshiInternational journal of geriatric psychiatry 37 8 2022年08月 [査読有り]
OBJECTIVE: Regular engagement in behavioral activities plays a crucial role against depressive symptoms in older adults. This study aims to explore the relationship between behavioral activities and the temporal evolution of depressive symptoms. METHODS: We included community-dwelling Japanese adults aged 64 or 65 years with and without depressive symptoms enrolled in the New Integrated Suburban Seniority Investigation (NISSIN) project. Depressive symptoms at baseline and follow-up were assessed using the 15-item Geriatric Depression Scale. Behavioral activities were measured by self-reported questions. Risk ratios and 95% confidence intervals were calculated using modified Poisson regression, adjusting for relevant sociodemographic variables and health-related confounders. RESULTS: During the 6 year follow-up period, 139 (10.1%) without depressive symptoms at baseline developed such symptoms over time, while 174 (51.6%) with depressive symptoms improved to the point of these symptoms being absent. The participants without depressive symptoms at baseline and those who engaged in social activity or daily walking at a continued regular frequency (CRF) or an increased frequency (IF) and exercise habits at CRF were the least likely to have depressive symptoms onset at follow-up. There was no significant difference between the changes in behavioral activities and the improvement of depressive symptoms after controlling for confounders. Participants engaging in a greater variety of behavioral activities at CRF were less likely to experience a new onset of depressive symptoms. CONCLUSIONS: Consistent and regular participation in one or more behavioral activities was significantly associated with the onset of depressive symptoms in Japanese community-dwelling older adults. - Taisuke Yamamoto, Takashi Kimura, Akiko Tamakoshi, Toshihiko MatsumotoJournal of psychoactive drugs 1 - 9 2022年07月27日 [査読有り]
Methamphetamine is an illegal drug with the greatest burdens in Japan. Social and medical measures to combat methamphetamine dependence have been implemented, but no reports on changes in the characteristics of methamphetamine use disorder patients have been conducted. We aimed to describe these changes, and provide information on the results of social and medical measures. We concatenated cross-sectional surveys from 2000 to 2020 and analyzed biennial changes. Twenty-year data from 2000 to 2018 were age-weighted according to the age structure in 2020. We performed Cochran-Armitage trend tests for crude and age-weighted changes in patient variables. There was an increase in the number of patients with methamphetamine use disorder undergoing treatment and those with a history of drug-related arrests. Patients who achieved 1-year abstinence increased, and those diagnosed with psychotic disorders decreased. Patients with a history of non-drug-related arrests and without revealing their source of methamphetamine decreased. The ages of the patient population increased, and patients with a history of benzodiazepine misuse increased. Social measures linking methamphetamine users to psychiatric care may increase the number of patients who undergo treatment. - Isaku Kurotori, Takashi Kimura, Wataru Sasao, Masahiko Abe, Hideki Kumagai, Akiko TamakoshiAllergology international : official journal of the Japanese Society of Allergology 72 1 128 - 134 2022年07月08日 [査読有り]
BACKGROUND: Fermented soybean (natto)-induced hypersensitivity reactions (natto allergy) are rare and can result in late-onset anaphylaxis. The allergen in natto is considered to be poly-γ-glutamic acid (PGA), and marine sports are a risk factor for natto allergy due to epicutaneous sensitization to PGA from cnidarian stings. However, no research on natto allergy in fishery workers has yet been performed. METHODS: We conducted a chart review of inpatients diagnosed with anaphylaxis due to natto at Hokkaido Prefectural Haboro Hospital between April 1, 2009, and August 31, 2020. We also administered self-report questionnaires about food hypersensitivity reactions to Japanese fishery workers, including members of the Kitarumoi Fishery Cooperative Association and part-time workers in this area, from February 1 to May 31, 2021. RESULTS: We found six inpatients (29 inpatients with food-induced anaphylaxis among approximately 11,000 community-dwelling residents) with late-onset anaphylaxis due to natto; all were involved in scallop aquaculture. The questionnaires revealed that 27 participants had natto allergy. We divided the fishery workers into a scallop aquaculture (Scallop) group (n = 211) and other fishery group (n = 106). The Scallop group was significantly associated with natto allergy after adjustments for confounders (OR: 5.73, 95% CI: 1.46-22.56) by logistic regression analysis. In the Scallop group, older age, experience in repairing nets, and a longer length of work experience were significantly related to participants with natto allergy (n = 23), but not participants without natto allergy (n = 181). CONCLUSIONS: Our results indicated an association between scallop aquaculture and natto allergy. - Calistus Wilunda, Sarah Krull Abe, Thomas Svensson, Norie Sawada, Shoichiro Tsugane, Keiko Wada, Chisato Nagata, Takashi Kimura, Akiko Tamakoshi, Yumi Sugawara, Ichiro Tsuji, Hidemi Ito, Tetsuhisa Kitamura, Ritsu Sakata, Tetsuya Mizoue, Keitaro Matsuo, Keitaro Tanaka, Yingsong Lin, Manami InoueInternational journal of cancer 2022年05月26日 [査読有り]
Sleep duration is emerging as an important modifiable risk factor for morbidity and mortality. We assessed the association between sleep duration and cancer incidence and mortality among Japanese adults using data from six population-based cohorts with 271 694 participants. During a total follow-up period of about 5.9 million person-years, we identified 40 751 incident cancer cases and 18 323 cancer deaths. We computed study-specific hazard ratios (HRs) and 95% confidence intervals (CIs) using Cox proportional hazards regression models and pooled the estimates using random-effects meta-analysis. Sleep duration of ≥ 10 h (vs. 7 h) was associated with increased risk of cancer incidence among women (HR 1.19, 95% CI 1.02-1.38), but not men, and increased risk of cancer mortality among men (HR 1.18, 95% CI 1.00-1.39) and women (HR 1.44, 95% CI 1.20-1.73). Sleep duration of ≤ 5 h (vs. 7 h) was not associated with cancer incidence and mortality. However, among post-menopausal women, sleep durations of both ≤ 5 h and ≥ 10 h (vs. 7 h) were associated with an increased risk of cancer mortality. Among Japanese adults, sleep duration of ≥ 10 h is associated with increased risk of cancer incidence and mortality among women and cancer mortality among men. This article is protected by copyright. All rights reserved. - Chi Yan Leung, Hsi-Lan Huang, Sarah Krull Abe, Eiko Saito, Md Rashedul Islam, Md Shafiur Rahman, Ai Ikeda, Norie Sawada, Akiko Tamakoshi, Yu-Tang Gao, Woon-Puay Koh, Xiao-Ou Shu, Ritsu Sakata, Ichiro Tsuji, Jeongseon Kim, Sue K Park, Chisato Nagata, San-Lin You, Jian-Min Yuan, Myung-Hee Shin, Wen-Harn Pan, Shoichiro Tsugane, Takashi Kimura, Wanqing Wen, Hui Cai, Kotaro Ozasa, Sanae Matsuyama, Seiki Kanemura, Yumi Sugawara, Aesun Shin, Keiko Wada, Chien-Jen Chen, Renwei Wang, Yoon-Ok Ahn, Habibul Ahsan, Paolo Boffetta, Kee Seng Chia, Keitaro Matsuo, You-Lin Qiao, Nathaniel Rothman, Wei Zheng, Daehee Kang, Manami InoueJAMA network open 5 5 e2214181 2022年05月02日 [査読有り]
Importance: Marital status has been shown to be associated with mortality, but evidence in Asian populations is limited. Objective: To examine the association of marital status with total and cause-specific mortality. Design, Setting, and Participants: This cohort study included individual participant data from 16 prospective studies in the Asia Cohort Consortium conducted between 1963 and 2015. Asian participants with complete information on marital and vital status were included. Study-specific hazard ratios (HRs) and 95% CIs were estimated using Cox proportional hazards model and then pooled using a random-effects meta-analysis. The analysis began in February 2021 and ended in August 2021. Exposures: Marital status. Main Outcomes and Measures: All-cause and cause-specific mortality. Results: Of 623 140 participants (326 397 women [52.4%] and 296 743 men [47.6%]; mean [SD] age, 53.7 [10.2] years; mean [SD] follow-up time, 15.5 [6.1] years), 123 264 deaths were ascertained. Compared with married individuals, those who were unmarried had pooled HRs of 1.15 (95% CI, 1.07-1.24) for total mortality, 1.12 (95% CI, 1.03-1.22) for cerebrovascular disease mortality, 1.20 (95% CI, 1.09-1.31) for coronary heart disease mortality, 1.17 (95% CI, 1.07-1.28) for circulatory system diseases mortality, 1.06 (95% CI, 1.01-1.11) for cancer mortality, 1.14 (95% CI, 1.05-1.23) for respiratory diseases mortality, and 1.19 (95% CI, 1.05-1.34) for external causes of death. Positive associations with total mortality were also observed for those who were single (HR, 1.62; 95% CI, 1.41-1.86), separated (HR, 1.35; 95% CI, 1.13-1.61), divorced (HR, 1.38; 95% CI, 1.13-1.69), and widowed (HR, 1.09; 95% CI, 1.04-1.13). In subgroup analyses, the positive association persisted across baseline health conditions, and the risk of death was more pronounced among men or people younger than 65 years. Conclusions and Relevance: This large pooled cohort study of individual participant data provides strong evidence that being unmarried, as well as belonging to the unmarried subcategories, was positively associated with total and cause-specific mortality. Investment of targeted social support services might need to be considered in light of the mortality differences between married and unmarried individuals. - Jun-ichiro Watanabe, Takashi Kimura, Takahiro Nakamura, Daisuke Suzuki, Takashi Takemoto, Akiko TamakoshiSSM - Population Health 17 100981 - 100981 2022年03月 [査読有り]
- Taisuke Yamamoto, Takashi Kimura, Akiko Tamakoshi, Toshihiko MatsumotoThe American journal on addictions 31 2 134 - 141 2022年01月31日 [査読有り]
BACKGROUND AND OBJECTIVES: Methamphetamine use disorder is the most common reason for psychiatrist visits among illicit drug users in Japan. Although variables associated with methamphetamine use and sex differences have been reported in the United States, Australia, and Asian countries, such studies are rare in Japan. We examined methamphetamine use within the past year among patients receiving treatment by sex and proposed important treatment targets. METHODS: This cross-sectional study analyzed the Nationwide Mental Hospital Survey on Drug-related Psychiatric Disorders. We divided 1086 men and 376 women into two groups according to methamphetamine use within the past year and conducted log-binomial regression analyses by sex to examine the variables associated with methamphetamine use. For methamphetamine users, the source was identified. RESULTS: Women were more likely to obtain methamphetamine from their friends, acquaintances, family members, or partners than men. Multivariable regression analysis showed that younger age in both sexes and higher educational attainment (prevalence ratio [PR] = 1.29; 95% confidence interval [CI] = 1.06-1.57) and employment (PR = 1.26; 95% CI = 1.05-1.51) were associated with methamphetamine use in men. Age-adjusted regression analysis showed that the variables associated with methamphetamine use were comorbid alcohol abuse and cannabis abuse in women and benzodiazepine abuse in both sexes. CONCLUSION AND SCIENTIFIC SIGNIFICANCE: In women, in particular, the surrounding relationships related to methamphetamine might be considered treatment targets. Young and working patients might need more accessible outpatient clinics and treatment programs. Comorbid substance abuse should be assessed and treated. - Haruhisa Baba, Yutaka Watanabe, Kazuhito Miura, Kimiya Ozaki, Takae Matsushita, Miyako Kondoh, Kazutaka Okada, Akira Hasebe, Tokiyoshi Ayabe, Kiminori Nakamura, Shinji Nakaoka, Katsuhiko Ogasawara, Teppei Suzuki, Hiroshi Saito, Takashi Kimura, Akiko Tamakoshi, Yutaka YamazakiGerodontology 39 1 49 - 58 2022年01月31日 [査読有り]
OBJECTIVE: To examine the association between oral frailty and oral Candida carriage as a general indicator of deteriorating oral function in older adults. BACKGROUND: Older adults exhibit an elevated risk of oral candidiasis caused by Candida. Although many studies have identified factors associated with oral Candida carriage, none have evaluated its relationship with oral function. MATERIALS AND METHODS: This study included 210 community-dwelling older adults aged ≥60 years who participated in wellness checks. Fungal flora expression in saliva samples was evaluated to identify oral C. albicans and C. glabrata. Participants were categorised by detection of neither strain (group 1), either one of the strains (group 2), or both strains (group 3). The relationship between oral Candida carriage and oral frailty was evaluated by multinomial logistic regression analysis. RESULTS: The participants included 58 men and 152 women with a mean age of 74.2 ± 6.1 years. A total of 88 (41.9%), 94 (44.8%) and 28 (13.3%) participants were assigned to groups 1, 2 and 3 respectively. In the multinomial logistic regression analysis, significant associations were observed between group 1 and group 2 for "Have you choked on your tea or soup recently?" and the number of applicable oral frailty items. Between group 1 and group 3, significant associations were observed for the number of remaining teeth, masticatory performance and the number of applicable oral frailty items. CONCLUSION: We obtained basic data useful for intervention studies aimed at verifying whether oral function management prevents deterioration of the oral bacterial flora. - Sachiko Sasaki, Koshi Nakamura, Shigekazu Ukawa, Emiko Okada, Shiho Amagasa, Shigeru Inoue, Takashi Kimura, Aya Yoshimura, Aya Tanaka, Takafumi Nakagawa, Akihiro Imae, Akiko TamakoshiBMC nephrology 23 1 7 - 7 2022年01月03日 [査読有り]
BACKGROUND: Sedentary behavior and decreased physical activity are associated with reduced kidney function, yet most evidence is based on self-reported physical activity. This study investigated the association between accelerometer-based physical activity level and kidney function in a general Japanese population. METHODS: A cross-sectional study was conducted in 440 community-dwelling Japanese participants, aged 35-79 years. Time (min/d) was assessed for the following types of physical activity: sedentary behavior, light physical activity (LPA), and moderate-to-vigorous physical activity (MVPA). Kidney function was assessed using estimated glomerular filtration rate (eGFR). A linear regression model was employed to calculate the β coefficient of eGFR for a 60-min/d increase in sedentary behavior and LPA and a 10-min/d increase in MVPA. A logistic regression model was used to calculate the odds ratio for low eGFR (< 60 versus ≥60 mL/min/1.73m2) for a 60-min/d or 10-min/d increase in each physical activity type. RESULTS: MVPA time and eGFR were positively associated in both men and women, after adjusting for age, body mass index, and other clinical characteristics (Men: β, 0.91; P = 0.021; Women: β, 0.70; P = 0.034). In women, sedentary behavior and eGFR were inversely associated after adjusting for the same factors (β, - 1.06; P = 0.048). The odds ratio (95% confidence interval) for low eGFR associated with a 60-min increase in sedentary behavior was 1.65 (1.07-2.55) after adjusting for the same factors in women. CONCLUSION: Longer sedentary behavior and shorter MVPA time were associated with lower kidney function in the Japanese population. - Ehab S Eshak, Chika Okada, Takashi Kimura, Sachiko Baba, Satoyo Ikehara, Hiroyasu Iso, For The Jecs GroupJournal of nutritional science and vitaminology 68 4 260 - 269 2022年 [査読有り]
Pregnancy is usually associated with dietary imbalances. We aim to assess the changes in Japanese women's diet and nutritional adequacy before and during pregnancy. In the Japan Environment and Children's Study (JECS), we recruited a large cohort of pregnant women (>100,000) from 15 Japanese communities. We assessed their diet before and during pregnancy by a food frequency questionnaire. The before and during pregnancy intakes of energy, macronutrients, and micronutrients were lower than the recommended level for Japanese women by 1% to 49%. The dietary intakes of pregnant women were lower than their intakes before pregnancy, except for milk, dairy products, and calcium. The daily during pregnancy intake of energy, carbohydrate, fat, protein, folic acid, and iron decreased by 85 kcal, 11.6 g, 2.3 g, 2.8 g, 20 μg, and 0.5 mg than the before pregnancy intake. Pregnant women's declined food and nutrients intakes were moderately correlated to their dietary intakes before pregnancy; the correlation coefficient ranged between 0.47 and 0.67. The inter-individual variability was greater than the intra-individual variability of the dietary intakes. Almost half of the pregnant women remained in the same intake quartile for all nutrients and food groups as before pregnancy. Yet, approximately 10% of pregnant women changed their pregnancy intake by ≥50% (≥2 quartiles up or down) compared to before pregnancy. In conclusion, the study identified low periconceptional dietary intakes among Japanese pregnant women. The low dietary intake of essential nutrients, such as folate, requires revising the Japanese national periconceptional dietary and supplementation guidelines. - Akinori Yaegashi, Takashi Kimura, Takumi Hirata, Akiko TamakoshiJournal of nutritional science and vitaminology 68 3 155 - 161 2022年 [査読有り]
This systematic review and meta-analysis aimed to investigate the association between green tea consumption and depression symptom risk, using subgroup analyses concerning study design, geographical region of study, adjustment factors, age, cut-off for the highest consumption category, and depression assessment methods applied. We used PubMed to search for relevant literature. The inclusion criteria were studies that (a) investigated this association as a primary or secondary outcome; (b) published in English; (c) assessed and reported hazard ratios or odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) for depression symptoms, or included sufficient information to allow their calculation; (d) included at least two groups differentiated based on green tea consumption (e.g., high and low); (e) reported the prevalence of depression symptoms in each group; and (f) reported the sample size for each group. Eight articles were found to meet all criteria. The results indicated that high green tea consumption is inversely associated with depression symptoms. The pooled OR was 0.66 (95% CI 0.58-0.74), and significant heterogeneity was not observed. Subgroup analysis showed that study design impacted results (cohort study [one study]: OR=0.29, 95% CI=0.04-2.14; cross-sectional study [seven studies]: OR=0.66, 95% CI=0.59-0.75). These findings suggest that green tea consumption reduces the risk of depression symptoms. This association was also observed in the cohort study included, but the results in which did not reach the significant level. Therefore, further cohort studies are needed to confirm the potential causal relationship in this regard. - Kenichi Katabami, Takashi Kimura, Takumi Hirata, Akiko TamakoshiInternal medicine (Tokyo, Japan) 61 9 1353 - 1359 2022年 [査読有り]
Objective This study assessed the risk factors of mortality from foreign bodies in the respiratory tract using the Japan Collaborative Cohort Study for the Evaluation of Cancer Risk data. Methods Data of 110,585 participants 40-79 years old living in 45 areas in Japan were collected between 1988 and 2009. Mortality from foreign bodies in the respiratory tract was assessed in a multivariable-adjusted analysis using a Cox proportional hazard regression model. Results Among all participants, 202 deaths occurred from foreign bodies in the respiratory tract. In the multivariable-adjusted model, older age [50-59 (hazard ratio, 4.93; 95% confidence interval, 1.91-12.74), 60-69 (hazard ratio, 14.96, 6.01-37.25) and 70-79 (hazard ratio, 53.81; 95% confidence interval, 21.44-135.02) years old compared to 40-49 years old], male sex (hazard ratio, 2.34; 95% confidence interval, 1.54-3.54), a history of apoplexy (hazard ratio, 7.04; 95% confidence interval, 4.24-11.67) and the absence of a spouse (hazard ratio, 1.56; 95% confidence interval, 1.05-2.32) were associated with an increased risk of mortality from foreign bodies in the respiratory tract. Conclusions Older age, male sex, medical history of apoplexy and the absence of a spouse were potential risk factors of mortality from foreign bodies in the respiratory tract. Especially in elderly men, social connections, such as cohabitation or relationships, may be important for ensuring the early detection of asphyxia and preventing death due to foreign bodies in the respiratory tract. - Rachana Manandhar Shrestha, Tetsuya Mizoue, Norie Sawada, Keitaro Matsuo, Keiko Wada, Keitaro Tanaka, Yingsong Lin, Yumi Sugawara, Hidemi Takimoto, Takashi Kimura, Hidemi Ito, Tetsuhisa Kitamura, Ritsu Sakata, Shiori Tanaka, Manami InoueJapanese journal of clinical oncology 2021年12月29日 [査読有り]
OBJECTIVE: The association between adult-attained height and risk of colorectal cancer remains elusive among the Japanese population. We performed a systematic review and meta-analysis of epidemiological studies in Japan. METHODS: We systematically searched the MEDLINE (PubMed) and Ichushi databases and complemented it with manual search to identify eligible studies. We extracted relative risks or odds ratios from the selected studies and conducted meta-analysis to estimate the summary relative risk with 95% confidence interval. We made the final judgment based on a consensus of the research group members considering both epidemiological evidence and biological plausibility. RESULTS: This systematic review identified four cohort and one case-control studies among the Japanese. The meta-analysis of these five studies showed the summary relative risk of 1.21 (95% confidence interval: 1.07-1.35) of overall colorectal cancer for the highest vs. lowest categories of height. In the analysis by the cancer subsite, the association was significant for colon cancer with a summary relative risk of 1.26 (95% confidence interval: 1.10-1.45) but not for rectal cancer 1.05 (95% confidence interval: 0.71-1.54). In the analysis by sex, tall stature was associated with a significantly increased risk of overall colorectal cancer in both sexes; the summary relative risk was 1.21 (95% confidence interval: 1.04-1.41) in men and 1.20 (95% confidence interval: 1.00-1.44) in women, respectively. CONCLUSIONS: The evidence to support that adult-attained height is associated with increased risk of colorectal cancer (colon cancer) among the Japanese population is 'probable'. - Akinori Yaegashi, Takashi Kimura, Takumi Hirata, Akiko TamakoshiGeriatrics & gerontology international 21 12 1077 - 1083 2021年12月 [査読有り]
Protein supplementation has been shown to be effective in attenuating the loss of lean body mass and muscle mass in older adults; however, its benefits as dietary protein remain unclear. This systematic review of observational studies aimed to investigate the association of dietary protein intake with skeletal muscle mass (SM). Observational studies that investigated the association of dietary protein intake with SM in older adults were retrieved from MEDLINE, Web of Science and Cochrane-CENTRAL databases. Of the 26 analyses in the 17 studies, 18 showed a significant positive association. In cohort studies, 55.6% (five of nine analyses) showed a significant positive association. Of these, four analyses were adjusted for well-known confounding factors, used energy-adjusted protein intake, and used the amount of change of SM between baseline and follow-up as the outcome, with two of them showing a significant positive association. Although 69.2% (18 of 26 analyses) of the 17 studies showed a significant positive association between dietary protein intake and SM in older adults, most studies were cross-sectional and had at least one important methodological limitation. Therefore, we could not draw any conclusions. Thus, well-designed cohort studies are needed in future to identify the association between dietary protein intake and SM in older adults. Geriatr Gerontol Int 2021; ••: ••-••. - Yoshihiro Saito, Sumitaka Kobayashi, Atsuko Ikeda-Araki, Sachiko Ito, Chihiro Miyashita, Takashi Kimura, Takumi Hirata, Akiko Tamakoshi, Michinori Mayama, Kiwamu Noshiro, Kinuko Nakagawa, Takeshi Umazume, Kentaro Chiba, Satoshi Kawaguchi, Mamoru Morikawa, Kazutoshi Cho, Hidemichi Watari, Yoshiya Ito, Yasuaki Saijo, Reiko KishiJournal of diabetes investigation 13 5 889 - 899 2021年11月30日 [査読有り]
AIMS/INTRODUCTION: We investigated the association between gestational diabetes mellitus (GDM) and perinatal outcomes stratified by pre-pregnancy body mass index (BMI) and/or gestational weight gain (GWG). MATERIALS AND METHODS: Data from the national birth cohort in the Japan Environment and Children's Study from 2011 to 2014 (n = 85,228) were used. Japan uses GDM guidelines of the International Association of Diabetes and Pregnancy Study Groups. The odds ratios (ORs) of perinatal outcomes were compared between women with and those without GDM. RESULTS: The OR (95% confidence interval [CI]) of having an SGA infant in the GDM group with a pre-pregnancy BMI of ≥25.0 kg/m2 and insufficient GWG (<2.75 kg) was 1.78 (1.02-3.12). The OR of having a large-for-gestational-age (LGA) infant of same BMI group with excessive GWG (>7.25 kg) was 2.04 (1.56-2.67). The OR of hypertensive disorders of pregnancy (HDP) was higher in women with a BMI ≥18.5 kg/m2 in the GDM group than in the non-GDM group. CONCLUSIONS: LGA and HDP were associated with pre-pregnancy BMI and GWG in either normal weight or overweight/obese women, and the relationship was strengthened when GDM was present. Women with GDM and a BMI of ≥25.0 kg/m2 are at risk of having SGA and LGA infants depending on GWG. - Wen Hao, Wenjing Zhao, Takashi Kimura, Shigekazu Ukawa, Ken Kadoya, Katsunori Kondo, Akiko TamakoshiBMC geriatrics 21 1 523 - 523 2021年10月02日 [査読有り][通常論文]
BACKGROUND: Gait was proved to be strongly associated with global cognitive function and multiple cognitive domains; however, previous research usually concentrated on individual gait parameters. This study used wearable sensors to measure gait parameters in different aspects and comprehensively explored the association of gait with global cognitive function and cognitive domains. METHODS: The data of this cross-sectional study were obtained from 236 community-dwelling Japanese older adults (125 men and 111 women) aged 70-81 years. Gait was measured by asking participants to walk a 6-m course and back using the Physilog® sensors (GaiUp®, Switzerland). Global cognitive function and cognitive domains were evaluated by face-to-face interviews using the Japanese version of the Montreal Cognitive Assessment. Twenty gait parameters were summarized as independent gait factors using factor analysis. A generalized linear model and linear regression model were used to explore the relationship of gait with global cognitive function and cognitive domains adjusted for several confounding factors. RESULTS: Factor analysis yielded four gait factors: general cycle, initial contact, propulsion, and mid-swing. Among them, general cycle factor was significantly associated with global cognitive function (β = - 0.487, [- 0.890, - 0.085]) and executive function (P = 0.049); initial contact was associated with executive function (P = 0.017). CONCLUSION: General cycle of gait might be the better marker of global cognitive function and gait is most strongly associated with executive function. The longitudinal relationships should be examined in future cohort studies. - Satoyo Ikehara, Hiroyasu Iso, Yoshihiro Kokubo, Kazumasa Yamagishi, Isao Saito, Hiroshi Yatsuya, Takashi Kimura, Norie Sawada, Motoki Iwasaki, Shoichiro TsuganeStroke 52 11 STROKEAHA120031212 - 3550 2021年09月09日 [査読有り][通常論文]
BACKGROUND AND PURPOSE: Several prospective cohort studies and a randomized clinical trial have shown the beneficial effects of peanut consumption on cardiovascular disease and its risk factors. We examined the association between peanut consumption and risk of cardiovascular disease in Japanese men and women. METHODS: We analyzed data of 74 793 participants aged 45 to 74 years who completed a lifestyle questionnaire including the validated food frequency questionnaire in the Japan Public Health Center-based Prospective Study. They were followed up from 1995 to 2009 for cohort I and from 1998 to 1999 to 2012 for cohort II. Peanut consumption was calculated from the food frequency questionnaire, and the end points were incidence of stroke, ischemic heart disease, and cardiovascular disease (stroke and ischemic heart disease). RESULTS: During a median follow-up of 14.8 years, 3,599 strokes and 849 ischemic heart diseases were reported. Higher peanut consumption was associated with reduced risks of total stroke, ischemic stroke, and cardiovascular disease among men and women. The multivariable hazard ratios (95% CIs) for the highest versus lowest quartiles of peanut consumption after adjustment for age, sex, public health center, smoking, alcohol consumption, perceived stress level, physical activity, vegetable, fruit, fish, soy, sodium and total energy intakes, body mass index, history of hypertension, history of diabetes, and cholesterol-lowering drug were 0.84 (0.77-0.93, P for trend=0.002) for total stroke, 0.80 (0.71-0.90, P for trend=0.002) for ischemic stroke, 0.93 (0.79-1.08, P for trend=0.27) for hemorrhagic stroke, 0.97 (0.80-1.17, P for trend=0.81) for ischemic heart disease and 0.87 (0.80-0.94, P for trend=0.004) for cardiovascular disease, and these associations were similarly observed in both sexes. CONCLUSIONS: Higher peanut consumption was associated with reduced risk of stroke, especially ischemic stroke, but not ischemic heart disease in Japanese men and women. - Ryodai Yamamura, Koshi Nakamura, Shigekazu Ukawa, Emiko Okada, Takafumi Nakagawa, Akihiro Imae, Tadao Kunihiro, Takashi Kimura, Takumi Hirata, Akiko TamakoshiObesity research & clinical practice 15 4 345 - 350 2021年06月11日 [査読有り][通常論文]
In Western populations, fecal concentrations of short-chain fatty acids (SCFAs) are positively correlated with the prevalence of obesity. However, gut microbiota involved in the production of SCFA varies between races. Our purpose was to investigate the associations between fecal SCFAs and the prevalence of obesity in a community-based Japanese population. We classified a total of 568 participants aged ≥18 into four quartiles of fecal concentrations of SCFA subtypes (acetate, butyrate, and propionate) and total SCFAs to compare the prevalence of obesity, defined as a body mass index ≥ 25.0 kg/m2. Using the first quartile SCFA group as a reference, the prevalence ratios of obesity were calculated for each SCFA group through a log-binomial regression model adjusted for major potentially confounding factors including age, sex, exercise habits, total energy intake, and total dietary fiber intake. In the study population, the prevalence of obesity was 35.8%. The prevalence ratios (95% confidence intervals) of obesity in the second, third, and fourth quartile groups of fecal total SCFAs were 1.30 (0.89-1.89), 1.74 (1.23-2.47) and 1.70 (1.19-2.41), respectively, after adjusting for the confounders. Similar positive associations were observed for every subtype. The prevalence ratios (95% confidence intervals) in the fourth quartile groups of fecal acetate, butyrate, and propionate were 1.41 (1.02-1.97), 2.16 (1.49-3.14), and 1.97 (1.35-2.89), respectively, after adjusting for the confounders. In conclusion, our results demonstrated that fecal SCFA concentrations of every subtype were positively associated with the prevalence of obesity in a community-based Japanese population. - 藤井 仁, 湯川 慶子, 新井 一郎, 児玉 知子, 木村 尚史Therapeutic Research 42 6 423 - 429 ライフサイエンス出版(株) 2021年06月 [査読有り][通常論文]
目的:2020年の改正食品衛生法で定められた4つの指定成分を含む健康食品が薬局でどの程度流通しているのか、特に取り扱いが多い薬局の特徴は何か、薬局でどの程度指定成分等含有食品のことが知られているかを明らかにすることを目的とする。方法:調査会社を通じて全国の薬局名簿から完全無作為に抽出した薬局1000店舗の仕入れ担当者に調査票を郵送し、(1)健康食品を取り扱っているか、(2)指定成分等含有食品が4つ定められる予定であることを知っているか、(3)4つの指定成分等含有食品が何かを知っているか、(4)4つの指定成分等含有食品を過去に取り扱ったことがあるか、(5)4つの指定成分等含有食品を今販売しているか、(6)今後、4つの指定成分等含有食品の取り扱いを続けるか、止めるか、(7)新たに既存の健康食品が指定成分等含有食品に指定されたらどのような対応をとるか、などについて質問した。結果:183の薬局からの回答を分析対象とした。有効回答率18.3%であった。制度自体の認知度、健康被害の報告義務、4つの指定成分等含有食品の名称、過去に生じた健康被害等についての認知度は非常に低かった。また、501社以上の規模をもつ大手チェーン店とネット販売をしている業者で認知度が高かった。結論:指定成分等含有食品の認知度は非常に低かったが、指定成分等含有食品が健康被害を生じさせうる商品であり、健康被害が生じた際には報告の義務が課されることを認識したうえで販売を続けようとする担当者はおらず、適切な情報提供によって販売を自制させることができると考えられた。また、ネット販売をしている薬局では指定成分等含有食品の認知度が高く、これらの業者は実店舗では販売しないがネットを介して販売している可能性があり、注意喚起が必要であると考えられる。(著者抄録) - Hugh Shunsuke Colvin, Takashi Kimura, Hiroyasu Iso, Satoyo Ikehara, Norie Sawada, Shoichiro TsuganeDigestive diseases (Basel, Switzerland) 40 3 385 - 393 2021年05月21日 [査読有り][通常論文]
INTRODUCTION: Studies investigating the risk of gallstones in the Japanese population are sparse. To our knowledge, this is the first prospective cohort study assessing risk factors of gallstones in Japan. METHODS: A nationwide population-based prospective cohort of 112,109 men and women, aged 40-69 years, self-completed questionnaires at baseline regarding exposures to potential risk factors, between 1990 and 1994. The occurrence of gallstones and cholecystectomy for gallstones were ascertained from another questionnaire after 10 years. Odds ratios and the 95% confidence intervals were calculated using the multivariate logistic regression. RESULTS: During the 10-year follow-up, 3,092 (5.0%) participants developed gallstones and 729 (1.2%) participants required cholecystectomy. Increasing age, high body mass index, and diabetes mellitus were associated with the risk of gallstones in both sexes. In men, weight gain or loss of >5 kg over the follow-up period and stress were associated with risk of gallstones, whereas alcohol intake was inversely associated with the risk. In women, weight gain of >5 kg during the follow-up period, smoking, menopause, and lipid-lowering drugs were associated with risk of gallstones, whereas late onset of menarche was inversely associated with risk of gallstones. The risk of cholecystectomy broadly reflected the risk of gallstones for both sexes respectively. CONCLUSION: Risk factors for both gallstones and cholecystectomy for gallstones are multifactorial and differ between men and women. Novel findings in this study include an inverse association between late onset of menarche and gallstones, and an association between self-reported stress in men and gallstones. - 北海道在住高齢者の近隣環境の認識と冬季における歩数田中 綾, 鵜川 重和, 佐々木 幸子, 吉村 彩, 天笠 志保, 井上 茂, 木村 尚史, 近藤 克則, 玉腰 暁子北海道公衆衛生学雑誌 34 2 101 - 108 北海道公衆衛生学会 2021年03月 [査読有り][通常論文]
目的 積雪寒冷地域である北海道6町に在住する高齢者の近隣環境の認識と冬季における1日平均歩数の目標達成との関連を明らかにする。対象と方法 要介護認定を受けていない69〜78歳、569人を対象に、環境に関する自記式質問紙調査と、3軸加速度活動量計による活動量調査を行い、データの得られた457人を解析対象者とした。1日の平均歩数を厚生労働省の示す目標値によって、目標達成群(男性7,000歩以上、女性6,000歩以上)と目標未達成群に分類し分析を行った。結果 目標達成群には男性の13.1%、女性の17.2%が分類された。運動や散歩に適した公園や歩道があることはないことに比べ冬季の歩数の性別、年齢で調整した目標達成割合比は1.86(95% CI:0.92-3.74)、生鮮食料品が手に入る商店・施設・移動販売が身近にあることは、ないことに比べ0.90(95% CI:0.57-1.45)だった。考察 積雪寒冷地域であっても運動や散歩に適した公園や歩道があることで、冬季においても歩数を維持できる可能性が示唆された。(著者抄録) - Keiko Yamada, Takashi Kimura, Meishan Cui, Yasuhiko Kubota, Eizaburo Tanaka, Kenta Wakaizumi, Satoyo Ikehara, Tadashi Kimura, Hiroyasu IsoPain 162 3 749 - 759 2021年03月01日 [査読有り][通常論文]
ABSTRACT: This prospective study examined (1) whether antenatal pain is associated with postnatal maternal bonding disorder (MBD) through postnatal depression and (2) whether intimate partner violence (IPV) has a moderating effect on the association between antenatal pain and postnatal MBD. We analyzed 77,326 pregnancies of women who completed self-report questionnaires including the SF-8 bodily pain item, the Edinburgh Postnatal Depression Scale, the Mother-to-Infant Bonding Scale, and an assessment of IPV. We conducted a mediation analysis to assess whether postnatal depression mediated the association between antenatal pain and MBD 1 year after delivery. A moderated mediation model was used to examine the conditional effect of IPV during pregnancy on the association between antenatal pain and postnatal MBD, operating through postnatal depression. All analyses were adjusted for demographic factors, socioeconomic factors, perinatal and infant factors, medical history, and psychological status. Of the 77,326 pregnancies, 5420 (7.0%) were characterized by persistent moderate-to-severe pain. The total effect of antenatal pain on MBD was significant (standardized path coefficient = 0.06, 95% confidence interval, 0.05-0.06) and postnatal depression dominantly mediated the association between antenatal pain and postnatal MBD (70.8% mediation). Contrary to our hypothesis, IPV during pregnancy did not moderate the association between antenatal pain and postnatal MBD. However, IPV during pregnancy did have independent negative effects on both postnatal depression and MBD. Our findings suggest that antenatal pain and postnatal depression should be assessed and treated with consideration of the presence of IPV during pregnancy to better monitor and prevent the development of MBD. - Yoko Kawanishi, Aiko Kakigano, Takashi Kimura, Satoyo Ikehara, Takuyo Sato, Takuji Tomimatsu, Tadashi Kimura, Hiroyasu Iso, On Behalf Of The Japan Environment And Children's Study GroupNutrients 13 2 2021年01月24日 [査読有り]
BACKGROUND: The association between coffee/tea intake and hypertensive disorders of pregnancy (HDP) remains unclear. This study aimed to investigate the association of caffeine, coffee, and tea intake during pregnancy with the risk of HDP. METHODS: We assessed this association in 85,533 singleton pregnant women with live births in the Japan Environment and Children's Study, a prospective cohort in Japan that included women from early pregnancy onward. Caffeinated and decaffeinated coffee and tea (green, oolong, and black) consumption during pregnancy was assessed using a validated food frequency questionnaire conducted at mid-pregnancy, and caffeine intake was calculated based on coffee and tea consumption. Multivariable logistic regression was used to assess the association with the risk of HDP. RESULTS: HDP developed in 2222 women (2.6%). Caffeine intake was weakly associated with increased risk of HDP; the multivariable odds ratio of HDP for the highest versus the lowest quartile was 1.26 (95% confidence interval: 1.11, 1.43). Coffee drinkers of two or more cups per day showed a decreased risk compared with non-drinkers (multivariable odds ratio 0.79; 0.62, 0.99) even after adjustment for total caffeine intake. Tea consumption was not associated with the risk of HDP. CONCLUSIONS: Our study suggests that higher caffeine intake may increase HDP risk, while coffee drinkers had a lower risk. Further high-quality studies are needed to replicate these findings, and to elucidate if other substances in coffee may be protective against HDP. - Yuri Aochi, Kaori Honjo, Takashi Kimura, Satoyo Ikehara, Hiroyasu IsoJournal of epidemiology and community health 75 6 531 - 9 2021年01月19日 [査読有り][通常論文]
BACKGROUND: Previous studies, which examined the association between employment status and postpartum depression, were limited by binary or ternary employment status measures (employed/unemployed or full-time/part-time/unemployed). This study examined the association between detailed employment status during pregnancy and risk of depressive symptomatology 1 month after childbirth, and the effect modification by one's perceived level of social support and household equivalent income. METHODS: Our study examined 76 822 participants in the Japan Environment and Children's Study. The exposure included maternal employment status during pregnancy (regular workers, dispatched workers, part-time workers, self-employed workers, non-employed and others), and the outcome was depressive symptomatology 1 month after childbirth: Edinburgh Postnatal Depression Scale (EPDS scores ≥9 and ≥13). Adjusted ORs and 95% CIs of depressive symptomatology associated with employment status were calculated by multivariable logistic regression. Subgroup analyses by perceived level of social support and household equivalent income were conducted. RESULTS: Compared with regular workers, the risk of depressive symptomatology (EPDS score ≥9) was higher for non-employed and others, and that (EPDS score ≥13) was so for part-time workers. There was no significant interaction by perceived level of social support and household equivalent income in the associations. However, part-time workers and non-employed had excess risk of depressive symptomatology among women with lower perceived level of social support, but not among those with the higher one. CONCLUSION: Compared with regular workers, part-time workers and non-employed had an increased risk of depressive symptomatology, which was confined to women with lower perceived level of social support. - Akinori Yaegashi, Takashi Kimura, Takumi Hirata, Shigekazu Ukawa, Koshi Nakamura, Emiko Okada, Takafumi Nakagawa, Akihiro Imae, Akiko TamakoshiNutrients 13 1 187 - 187 2021年01月09日 [査読有り][通常論文]
Whether the source of dietary protein intake is related to appendicular skeletal muscle mass (AMM) and muscle mass (MM) remains unclear. We conducted this cross-sectional study of 277 residents (115 men, 162 women) aged ≥65 years in Japan to examine the association of the amount of dietary protein intake with AMM and MM. We measured dietary protein intake using a brief self-administered diet history questionnaire. AMM and MM were assessed based on bioelectrical impedance. Multivariable linear regression analyses were used to estimate β coefficients that were adjusted for potential confounders. Among Japanese women aged ≥75 years, but not among women aged 65-74 years, dietary animal protein intake was significantly associated with AMM (β (95% confidence interval (CI)): 0.25 (0.10, 0.40)) and MM (β (95% CI): 0.40 (0.16, 0.64)). However, dietary vegetable protein intake was not associated with AMM (β (95% CI): -0.17 (-0.74, 0.41)) and MM (β (95% CI): -0.30 (-1.23, 0.63)). Furthermore, in men aged ≥65 years, dietary protein intake was not associated with AMM or MM. In conclusion, dietary animal protein intake, but not vegetable protein intake, were positively associated with AMM and MM among this population of Japanese women aged ≥75 years. - Satoshi Sunohara, Toshiaki Asakura, Takashi Kimura, Shun Ozawa, Satoshi Oshima, Daigo Yamauchi, Akiko TamakoshiPloS one 16 9 e0257107 2021年 [査読有り][通常論文]
Due to COVID-19, many countries including Japan have implemented a suspension of economic activities for infection control. It has contributed to reduce the transmission of COVID-19 but caused severe economic losses. Today, several promising vaccines have been developed and are already being distributed in some countries. Therefore, we evaluated various vaccine and intensive countermeasure strategies with constraint of economic loss using SEIR model to obtain knowledge of how to balance economy with infection control in Japan. Our main results were that the vaccination strategy that prioritized younger generation was better in terms of deaths when a linear relationship between lockdown intensity and acceptable economic loss was assumed. On the other hand, when a non-linearity relationship was introduced, implying that the strong lockdown with small economic loss was possible, the old first strategies were best in the settings of small basic reproduction number. These results indicated a high potential of remote work when prioritizing vaccination for the old generation. When focusing on only the old first strategies as the Japanese government has decided to do, the strategy vaccinating the young next to the old was superior to the others when a non-linear relationship was assumed due to sufficient reduction of contact with small economic loss. - Keiko Yamada, Takashi Kimura, Meishan Cui, Yasuhiko Kubota, Satoyo Ikehara, Hiroyasu IsoEuropean journal of pain (London, England) 25 4 872 - 885 2020年12月20日 [査読有り][通常論文]
BACKGROUND: Persistent pain during pregnancy is a significant health issue, which could be correlated with psychological distress resulting from inadequate social support. This study aims to investigate whether the relationship between poor social support and antenatal pain is mediated by psychological distress. We also aimed to examine whether social cohesion moderates the influence of psychological distress on the relationship between social support and antenatal pain. METHODS: We analysed 94,517 pregnancies of women from a Japanese national birth cohort completed questionnaires assessing pain, psychological distress, social support and social cohesion. Psychological distress was assessed using the Kessler Psychological Distress Scale. Two types of models were used: the mediation model to examine whether the association between social support and pain was mediated by psychological distress; the moderated mediation model to analyse whether social cohesion buffered the negative effect of inadequate social support on pain. Demographic, socioeconomic and psychological factors were controlled for in all analyses. RESULTS: Psychological distress was fully mediated the association between social support and pain. Social cohesion had a focal moderation effect on the inverse association between social support and psychological distress (unstandardized regression coefficient [β] = 0.09; 95% CI, 0.07-0.11) and functioned as moderator for the indirect effect of social support on antenatal pain (index of moderated mediation = 0.006; 95% CI, 0.004-0.007). CONCLUSIONS: Poor social support was related to antenatal pain through psychological distress, possibly buffered by social cohesion. During the antenatal period, social support and cohesion are important for women. SIGNIFICANCE: In this study, poor social support was found to be associated with pain intensity during pregnancy, which was mediated by psychological distress and might be buffered by desirable social cohesion. This finding could potentially help healthcare providers and policy makers to understand the importance of desirable social cohesion in preventing pain among pregnant women. - Reiji Kojima, Shigekazu Ukawa, Hiroshi Yokomichi, Aya Tanaka, Takashi Kimura, Shiho Amagasa, Shigeru Inoue, Katsunori Kondo, Akiko TamakoshiEuropean geriatric medicine 12 1 91 - 98 2020年09月25日 [査読有り][通常論文]
PURPOSE: The aim of the present study was to investigate the association between falls, including falls on frozen roads, and physical activity among older people living in cold, snowy regions in Japan. METHODS: Participants were subjects of the Japan Gerontological Evaluation Study 2016 who had agreed to the Hokkaido additional visit survey in winter 2017/18 and lived in cold, snowy regions in Japan. The analysis included 461 participants (mean age 74.7 years; standard deviation 2.8 years; 46.5% male). Sociodemographic characteristics, physical activity (min/day of moderate-to-vigorous intensity physical activity [MVPA] and light intensity physical activity, and walking steps/day) measured by accelerometer, cognitive function, depression, visual impairment, and history of stroke were surveyed. Poisson regression analyses were performed to clarify the association between prevalence of falls and physical activity. RESULTS: Of those who reported a fall with location, 86 (69.9%) fell on frozen roads, 24 (19.5%) fell on unfrozen roads and 13 (10.6%) fell indoors. There were significant positive associations between MVPA (adjusted prevalence ratio [aPR] Tertile [T] 3 vs T1, 1.73; 95% confidence interval [CI], 1.04-2.87) and all falls. When limited to falls on frozen roads, higher MVPA levels and walking steps were associated with falls on frozen roads (MVPA, aPR T3 vs T1, 2.16; 95% CI, 1.19-3.94; walking steps, aPR T3 vs T1, 2.49; 95%CI 1.33-4.68). CONCLUSION: The risk of falls, especially on frozen roads, increased among active older people living in cold, snowy regions, and environmental factors should be considered when determining prevention strategies. - Shiho Amagasa, Shigeru Inoue, Shigekazu Ukawa, Sachiko Sasaki, Koshi Nakamura, Aya Yoshimura, Aya Tanaka, Takashi Kimura, Takafumi Nakagawa, Akihiro Imae, Ding Ding, Hiroyuki Kikuchi, Akiko TamakoshiJournal of epidemiology 31 10 530 - 536 2020年08月08日 [査読有り][通常論文]
BackgroundPrevious research has established that women accumulate less moderate-to-vigorous physical activity (MVPA) than men. To date, however, little is known about the gender differences in device-based activity patterns of sedentary behavior (SB) and light-intensity physical activity (LPA). We aimed to compare time spent in SB and different intensities of physical activity taking into account of co-dependence of time use domains.MethodsThis cross-sectional study was conducted in Suttu town, Hokkaido, Japan. Data were analyzed from 634 Japanese adults (278 men, aged 19-92 years) who provided valid accelerometer (HJA-750C) data. Gender differences in activity behavior patterns were tested by multivariate analysis of covariance (MANCOVA) based on isometric log-ratio transformations of time use, adjusting for age. We also developed bootstrap percentile confidence intervals (CI) to support the interpretation of which behavior differed between genders.ResultsOverall, participants had percent time spent in SB, LPA, MVPA during wearing time (mean 14.8 hours) corresponding to 53.9%, 41.7%, and 4.4%, respectively. Activity behavior patterns differed significantly between genders after controlling for time spent in all activities. Women spent relatively 13.3% (CI: 9.9, 15.9) less time in SB and 19.8% (CI: 14.9, 24.6) more time in LPA compared to men. The difference of time spent in MVPA was not statistically significant.ConclusionsIn contrast with previous studies, our findings suggest that Japanese women are more physically active than men when all intensities of activities are considered. Given the health benefits of LPA, evaluating only MVPA may disproportionately underestimate the level of physical activity of women. - Jia-Yi Dong, Takashi Kimura, Satoyo Ikehara, Meishan Cui, Yoko Kawanishi, Tadashi Kimura, Kimiko Ueda, Hiroyasu IsoEuropean journal of nutrition 60 2 897 - 904 2020年06月06日 [査読有り][通常論文]
BACKGROUND: Intervention studies have shown that isoflavone treatment improved glucose metabolism, indicating that soy intake may have a potential role in diabetes prevention. OBJECTIVES: We aimed to investigate the prospective association of soy isoflavone and soy food intakes with incidence of gestational diabetes mellitus (GDM) in a birth cohort study. METHODS: We recruited 97,454 pregnant women (median gestational age 12 weeks) between January 2011 and March 2014. Dietary intakes during the 12 months preceding study enrollment were assessed by a semi-quantitative food frequency questionnaire. The relative risks of GDM associated with soy isoflavone and soy food intakes were obtained by Poisson regression. Demographic information, histories of diseases, socioeconomic status, lifestyles, and dietary habits, obtained by a self-administrated questionnaire, were used for covariate adjustments. RESULTS: We identified 1904 cases of GDM (2.2%) among 84,948 women. Compared with those in the lowest quintile of soy isoflavone intake, women in the highest quintile were found to have experienced a significantly lower risk of GDM (multivariate relative risk = 0.82; 95% confidence interval: 0.70, 0.95; P for trend = 0.05). Similar results were observed for genistein and daidzein. Regarding soy foods, intakes of miso soup and natto were inversely associated with GDM incidence (both P for trend ≤ 0.01), whereas the association for tofu intake appeared to be nonlinear (P for trend = 0.74). CONCLUSIONS: Higher intakes of miso soup and natto before and during early pregnancy, compared with lower intakes, may be associated with a lower incidence of GDM. - Jia-Yi Dong, Satoyo Ikehara, Takashi Kimura, Meishan Cui, Yoko Kawanishi, Tadashi Kimura, Kimiko Ueda, Hiroyasu Iso, The Japan Environment And Children's Study GroupNutrients 12 5 2020年05月02日 [査読有り][通常論文]
There is little evidence linking eating speed to gestational diabetes mellitus (GDM) incidence. We therefore aimed to evaluate the prospective association of eating speed with GDM incidence. Overall, 97,454 pregnant women were recruited between January 2011 and March 2014. Singleton pregnant women who did not have GDM, heart disease, stroke, cancer, type 1 diabetes, and/or type 2 diabetes at the time of study enrollment were eligible. Each woman was asked about her eating speed at that time via a questionnaire. Odds ratios of GDM in relation to eating speed were obtained using logistic regression. Among the 84,811 women eligible for analysis, 1902 cases of GDM were identified in medical records. Compared with women who reported slow eating speed, the age-adjusted odds ratios (95% confidence interval) of GDM for women who reported medium, relatively fast, or very fast eating speed were 1.03 (0.90, 1.18), 1.07 (0.94, 1.23), and 1.28 (1.05, 1.58), respectively. Adjustment for demographic, lifestyle-related, and dietary factors including dietary fat, dietary fiber, and energy intakes yielded similar results. The association was attenuated and no longer significant after further adjustment for pre-pregnancy body mass index. The mediation analysis showed that being overweight accounted for 64% of the excess risk of GDM associated with eating speed. In conclusion, women who reported very fast eating speed, compared with those reporting slow eating speed, were associated with an increased incidence of GDM, which may be largely mediated by increased body fat. - Ehab S Eshak, Chika Okada, Sachiko Baba, Takashi Kimura, Satoyo Ikehara, Takuyo Sato, Kokoro Shirai, Hiroyasu IsoThe British journal of nutrition 124 6 1 - 26 2020年04月21日 [査読有り][通常論文]
Maternal diet during pregnancy can influence foetal growth; however, the available evidence is controversial. We aimed to assess whether maternal diet of Japanese women in mid-pregnancy can affect their offspring's birth size via collection of questionnaire and medical record data. The studied sample was a large cohort of paired mothers and their singleton offspring (n= 78,793) from 15 areas allover Japan who participated in the Japan Environment and Children's Study (JECS).The mid-pregnancy intakes of total energy, macronutrients and vitamins were lower than the recommended intakes for pregnant Japanese women. Maternal total energy intake was positively associated with the offspring's birth weight; 10-g mean difference in the offspring's birth weight of mothers in the lowest (3,026 g) versus highest (3,036 g) quartiles of energy intake. Carbohydrate intake was positively associated with the offspring's birth length (mean difference of 0.7 cm) and inversely associated with the ponderal index (mean difference of 0.8 g/cm3). Offspring of mothers in the highest versus lowest quartiles of total dietary fiber intake were on average 9 g heavier and had 0.3 cm longer birth length and 0.2 cm longer head circumference. The highest in reference to lowest intake quartile of vitamin C was associated with 13 g and 0.7 cm mean differences in the offspring's birth weight and length respectively. Several other associations were evident for maternal vitamins intakes and the offspring's birth size.In conclusion, maternal dietary intakes of energy, dietary fiber, carbohydrate and vitamins during pregnancy were associated with the offspring's birth size. - Jia-Yi Dong, Satoyo Ikehara, Takashi Kimura, Meishan Cui, Yoko Kawanishi, Tadashi Kimura, Kimiko Ueda, Hiroyasu IsoThe American journal of clinical nutrition 111 4 829 - 834 2020年04月01日 [査読有り][通常論文]
BACKGROUND: There is little evidence linking breakfast skipping to the incidence of gestational diabetes mellitus (GDM). OBJECTIVES: We aimed to evaluate the prospective association of breakfast consumption with the incidence of GDM. METHODS: A total of 103,099 pregnancies were registered during study enrollment (January 2011 to March 2014), involving 97,454 pregnant women from 15 areas across Japan. Singleton pregnant women free of GDM, stroke, heart disease, cancer, and type 1 or type 2 diabetes at the study enrollment were eligible for analysis. We used a self-administered questionnaire to obtain data on demographic information, socioeconomic status, self-rated health status, disease history, lifestyle, and dietary habits of each woman at study enrollment. A semiquantitative FFQ was used for dietary assessment. We used logistic regression to obtain the OR of GDM in relation to breakfast consumption. RESULTS: Among 84,669 pregnant women for analysis, 1935 cases of GDM were documented. After adjustment for potential confounding factors including prepregnancy BMI, the multivariable-adjusted ORs of GDM for women who consumed breakfast 5-6 times/wk, 3-4 times/wk, and 0-2 times/wk were 1.09 (95% CI: 0.93, 1.27), 1.14 (95% CI: 0.96, 1.34), and 1.21 (95% CI: 1.05, 1.41), respectively, compared with daily breakfast eaters. The association appeared to be dose dependent (P-trend = 0.006) and was not significantly modified by prepregnancy BMI. CONCLUSIONS: Breakfast consumption <3 times/wk before and during early pregnancy, compared with daily consumption, was associated with an increased odds of developing GDM. - Keiko Yamada, Takashi Kimura, Satoyo Ikehara, Meishan Cui, Yasuhiko Kubota, Kenta Wakaizumi, Takashi Takeda, Hiroyasu IsoJournal of anesthesia 34 2 202 - 210 2020年04月 [査読有り][通常論文]
PURPOSE: Analgesic medication epidemic during pregnancy is an important issue in Western countries. However, no large epidemiological study involving pregnant women with pain and their medication use has been conducted in Japan. This study examined the current situation of medication use for non-cancer pain during the perinatal period in Japan using national cohort data. METHODS: We analyzed 94,649 pregnant women who completed a self-report questionnaire investigating bodily pain and an interview-based medication use survey. Medication use before and during pregnancy and new medication administration/discontinuation during pregnancy were compared between women with and without pain during pregnancy using multivariable covariance analysis. RESULTS: Mild pain was reported by 50.4% of pregnant women in the first trimester (survey 1) and 61.8% in the second/third trimester (survey 2). Moderate-to-severe pain was reported by 15.4% of women in survey 1 and 22.4% in survey 2. In survey 1, 6.2% of women used prescribed analgesics and 1.6% used over-the-counter analgesics. In survey 2, prescribed and over the counter analgesics were used by 12.2% and 0.8% of women, respectively. Other pain-related medications were rarely used (< 1.0%). Pregnant women with moderate-to-severe pain showed a lower proportion of discontinuation of analgesics and a higher proportion of new administration of prescription and transdermal analgesics compared with those without pain. CONCLUSIONS: Although a large proportion of pregnant women experience pain, medication use for pain during pregnancy is low in Japan compared with Western countries (50-60%). Adequate treatment or support may be necessary for pregnant women experiencing pain in Japan. - Meishan Cui, Takashi Kimura, Satoyo Ikehara, Jia-Yi Dong, Kimiko Ueda, Yoko Kawanishi, Tadashi Kimura, Hiroyasu IsoJournal of affective disorders 264 76 - 81 2020年03月01日 [査読有り][通常論文]
INTRODUCTION: Previous studies in Western countries have examined the association between prenatal smoking and risk for Postpartum depression (PPD). However, evidence from Japan is lacking, despite the high prevalence of smoking among pregnant women. Therefore, we examined the association between prenatal smoking and PPD among pregnant Japanese women. METHODS: We analyzed data for up to 1 month after childbirth from the Japan Environment and Children's Study (JECS), a nationwide birth cohort study. Among the 103,070 pregnant women recruited, 80,872 eligible participants were included in the analysis. PPD was defined as a score of ≥9 on the Edinburgh Postnatal Depression Scale (EPDS). Prenatal smoking and length of smoking cessation among ex-smokers were obtained using self-administered questionnaires at second/third trimester. RESULTS: Among 80,872 pregnant women, 9.0% reported PPD. Multivariable-adjusted odds ratios (OR) (95% confidence intervals) for PPD (reference: never smoked) were 1.24 (1.12-1.37) for women who quit smoking after becoming pregnant, and 1.38 (1.21-1.56) for those who smoked during pregnancy. Compared with women who had never smoked, those who quit smoking ≤5 years before childbirth had a higher occurrence of PPD, with a multivariable-adjusted OR of 1.10 (1.00-1.22). LIMITATIONS: Questionnaire data was self-reported by participants, thus smoking status might be under-reported. CONCLUSIONS: Women who smoked during pregnancy, quit smoking after becoming pregnant, and quit smoking ≤5 years before childbirth are more likely to experience PPD than those who had never smoked. - Sachiko Baba, Takashi Kimura, Satoyo Ikehara, Kaori Honjo, Ehab S. Eshak, Takuyo Sato, Hiroyasu Iso, Toshihiko Kawamoto, Hirohisa Saito, Reiko Kishi, Nobuo Yaegashi, Koichi Hashimoto, Chisato Mori, Shuichi Ito, Zentaro Yamagata, Hidekuni Inadera, Michihiro Kamijima, Takeo Nakayama, Masayuki Shima, Yasuaki Hirooka, Narufumi Suganuma, Koichi Kusuhara, Takahiko KatohArchives of Women's Mental Health 23 1 131 - 137 2020年02月01日 [査読有り][通常論文]
© 2018, The Author(s). Pregnancy intention is reported to be associated with the risk of postpartum depression (PPD), but the impact of feelings toward being pregnant on PPD is unknown. We aimed to examine whether feelings toward being pregnant are associated with PPD at 1 month after childbirth. In our nationwide study between 2011 and 2014 in Japan, we used multivariate logistic regression analyses to examine the associations between pregnancy intention and feelings toward being pregnant with PPD [Edinburgh Postnatal Depression Scale (EPDS score > 9 or > 12)] among Japanese women. Among 92,431 women, 14.0 and 5.4% had PPD with EPDS scores > 9 and > 12, respectively. Compared with women who felt very happy to be pregnant, those whose pregnancy was unintended but happy, unintended and confused, those who felt troubled, and those who felt no emotion toward being pregnant had increased risks of PPD [multivariable odds ratios (95% confidence intervals (CIs)) = 1.17 (1.11–1.22), 1.39 (1.29–1.49), 1.74 (1.42–2.14), and 1.58 (1.22–2.02), respectively, for EPDS score > 9]. Those associations were more evident without antenatal possible mental illness (K6 score < 13). Women whose pregnancy was unintended should be regarded as targets for the early detection and prevention of PPD irrespective of whether they felt happy or confused. - Kumi Hirokawa, Takashi Kimura, Satoyo Ikehara, Kaori Honjo, Kimiko Ueda, Takuyo Sato, Hiroyasu IsoJournal of autism and developmental disorders 50 8 2698 - 2709 2020年01月29日 [査読有り][通常論文]
The purpose of the present study was to investigate associations of dietary intake including vitamin D, folate, and n-3 and n-6 polyunsaturated fatty acids (PUFA) in pregnant women with broad autism phenotype (BAP). The Japan Environment and Children's Study is a government-funded birth cohort study. All complete data of 92,011 were analyzed. The Japanese version of the Autism Spectrum Quotient was used to assess mothers' BAP level, and a food frequency questionnaire was used to estimate their dietary intake. Mothers with BAP consumed less vegetables, fruits, and fish and shellfish, and they consumed lower folate, vitamin C, vitamin D, and n-3 PUFA than their counterparts. Dietary intervention should be considered for pregnant women with high BAP scores. - Ryodai Yamamura, Koshi Nakamura, Naoya Kitada, Tomoyasu Aizawa, Yu Shimizu, Kiminori Nakamura, Tokiyoshi Ayabe, Takashi Kimura, Akiko TamakoshiBioscience of microbiota, food and health 39 1 11 - 17 2020年 [査読有り][通常論文]
In recent years, short-chain fatty acids (SCFAs) have been reported to play an important role in maintaining human health. Fecal SCFA concentrations correlate well with colonic SCFA status and gut microbiota composition. However, the associations with the gut microbiota functional pathway, dietary intake, blood SCFAs, and fecal SCFAs remain uncertain. To clarify these relationships, we collected fecal samples, blood samples, and dietary habit data from 12 healthy adults aged 22-51 years. The relative abundance of several SCFA-producing bacteria, gut microbiota diversity, and functional pathways related to SCFA biosynthesis were positively associated with fecal SCFAs even after adjusting for age and sex. Furthermore, fecal acetate was likely to be positively associated with serum acetate. By contrast, dietary intake was not associated with fecal SCFAs. Overall, the present study highlights the potential usefulness of fecal SCFAs as an indicator of the gut microbiota ecosystem and dynamics of SCFAs in the human body. - Tanigawa K, Ikehara S, Kimura T, Imano H, Muraki I, Shirai K, Tamakoshi A, Iso HJournal of epidemiology 30 11 509 - 515 2019年11月16日 [査読有り][通常論文]
BACKGROUND: Reproductive history has been addressed as a risk factor for cardiovascular disease (CVD). We examined the relationship between reproductive history and CVD mortality in Japanese women. METHODS: We followed 53,836 women without previous CVD or cancer history from 1988-1990 to 2009 in a prospective cohort study. Hazard ratios (HRs) of CVD mortality were estimated according to the number of deliveries and maternal age at first delivery. RESULTS: During the follow-up, 2,982 CVD-related deaths were identified. There was U-shaped association between the number of deliveries and risk of CVD mortality with reference to three deliveries, although the excess risk of CVD mortality associated with ≥5 deliveries was of borderline statistical significance. The corresponding multivariable HRs (95% CIs) were 1.33 (1.12-1.58) and 1.11 (0.99-1.24). In addition, a higher CVD mortality was associated with maternal age ≥28 years at first delivery than maternal age of 24-27 years at first delivery. The multivariable HRs were 1.22 (1.10-1.36) for 28-31, and 1.26 (1.04-1.52) for ≥32 years at first delivery. Moreover, among women with ≥3 deliveries, maternal age ≥28 years at first delivery was associated with 1.2- to 1.5-fold increased CVD mortality. CONCLUSION: The number of deliveries showed a U-shaped association with risk of CVD mortality. Higher maternal age at first delivery was associated with an increased risk of CVD mortality, and excessive risk in women aged ≥28 years at first delivery was noted in those with ≥3 deliveries. - Dong JY, Kimura T, Ikehara S, Cui M, Kawanishi Y, Yamagishi K, Ueda K, Iso H, the Japan Environment, Children’s Study GroupThe British journal of nutrition 122 8 936 - 941 2019年10月28日 [査読有り][通常論文]
The association of chocolate consumption with risk of gestational diabetes has not been examined. We aimed to investigate the prospective association between chocolate consumption and risk of gestational diabetes in a large birth cohort in Japan. A total of 97 454 pregnant women with a median gestational age of 12 weeks were recruited from January 2011 to March 2014. Data on demographic information, disease history, socio-economic status, lifestyle and dietary habits were obtained at the study enrolment. Dietary intake during the past 12 months before study enrolment was assessed through a semi-quantitative FFQ. The logistic regression was used to obtain the OR of gestational diabetes in relation to chocolate consumption. Among 84 948 women eligible for the analysis, 1904 cases of gestational diabetes (2·2 %) were identified during the period of pregnancy. After controlling for potential confounding factors including age, smoking status, drinking status, education level, occupation, pre-pregnant BMI, depression, previous history of macrosomia babies, parity, physical activity and dietary factors, women in the highest quartile of chocolate consumption, compared with those in the lowest quartile, had a significantly lower risk of developing gestational diabetes (OR 0·78, 95 % CI 0·67, 0·90; P for trend = 0·002). Stratified analyses suggested that the association was not significantly modified by pre-pregnancy BMI, age, parity, smoking status or drinking status. The present prospective cohort study provided evidence that chocolate consumption was associated with a significant lower risk of gestational diabetes in Japanese women. - Ikehara S, Kimura T, Kakigano A, Sato T, Iso H, Japan Environment Children's Study GroupBJOG : an international journal of obstetrics and gynaecology 126 12 1448 - 1454 2019年08月 [査読有り][通常論文]
- Kumi Hirokawa, Takashi Kimura, Satoyo Ikehara, Kaori Honjo, Takuyo Sato, Kimiko Ueda, Hiroyasu IsoJournal of affective disorders 243 485 - 493 2019年01月15日 [査読有り][通常論文]
BACKGROUND: Broader autism phenotype (BAP) refers to the expression of behavioral and cognitive dispositions similar to autism spectrum disorder. The present study investigated whether mothers' BAP was prospectively associated with maternal attachment, and if postpartum depression modified this association. METHODS: The Japan Environment and Children's Study (JECS) is a national and government-funded birth cohort study that began in January 2011. Among the 103,099 mothers enrolled, 87,369 mothers without a history of depression were included in the analysis. Self-administered questionnaires were used. These included: the Japanese version of the Autism Spectrum Quotient, the Mother to Infant Bonding Scale, and the Edinburgh Postnatal Depression Scale. Logistic regression analyses were performed. RESULTS: The BAP during the second or third trimester of pregnancy was linearly associated with an increased risk of postpartum depression and insecure maternal attachment when infants were one month old (p for trend < 0.001), after adjusting for confounding variables. When stratified by postpartum depression, among the BAP subscales, deficiencies in social skills and communication were associated with an increased risk of insecure maternal attachment in mothers without postpartum depression. The relationships between the BAP subscales and maternal attachment were attenuated among mothers with postpartum depression. LIMITATIONS: Only five items of the Mother to Infant Bonding Scale were used in the present study, and thus the results should be interpreted with caution. CONCLUSIONS: Mothers' BAP was predictive of insecure maternal attachment toward their infant. Postpartum depression partially moderated the associations between mothers' BAP and insecure maternal attachment. - Kaori Honjo, Takashi Kimura, Sachiko Baba, Satoyo Ikehara, Naomi Kitano, Takuyo Sato, Hiroyasu Iso, Reiko Kishi, Nobuo Yaegashi, Koichi Hashimoto, Chisato Mori, Shuichi Ito, Zentaro Yamagata, Hidekuni Inadera, Michihiro Kamijima, Toshio Heike, Hiroyasu Iso, Masayuki Shima, Yasuaki Kawai, Narufumi Suganuma, Koichi Kusuhara, Takahiko KatohSocial Science and Medicine 217 65 - 72 2018年11月 [査読有り][通常論文]
© 2018 Elsevier Ltd There are many psychosocial and biomedical risk factors for postpartum depression (PPD). However, associations between co-resident family members and PPD risk have not been examined. This study investigated whether co-resident family members were associated with risk for PPD during 1 month postpartum among Japanese women, and if these associations were modified by household income and their perceived partner's involvement in childcare. The sample comprised 86,490 women. Data were drawn from the Japan Environment and Children's Study, a large-scale national cohort study started in 2011. Our major predictor was co-resident family members when they registered around the first trimester of the women's pregnancy: partner, parent(s), parent(s)-in-law, or child(ren). The outcome was PPD at 1 month after delivery, assessed by the Edinburgh Postnatal Depression Scale. Adjusted odds ratios (OR) for family members and PPD incidence were calculated using multivariable logistic regression analysis. Subgroup analyses were conducted by household income and perceived partner's involvement in childcare. Adjusted ORs (95% confidence interval) for PPD for those not living with their partner, parent(s), parent(s)-in-law, or child(ren) compared with those who lived with these family members were 1.21 (1.07–1.37), 1.13 (1.03–1.24), 0.91 (0.84–0.98), and 1.42 (1.31–1.53), respectively. The level of perceived partner's involvement in childcare changed the identified association between family member and PPD. We found that “who a pregnant woman lives with” affects the risk of PPD in the first month postpartum, and high levels of perceived partner's involvement in childcare reduced harmful effects/increased protective effect of family members on PPD incidence. These findings suggested that interventions to increase perceived partner's support for childcare may be effective in preventing PPD, regardless of living situation. - Takashi Kimura, Hiroyasu Iso, Kaori Honjo, Satoyo Ikehara, Norie Sawada, Motoki Iwasaki, Shoichiro TsuganeJOURNAL OF EPIDEMIOLOGY 26 6 315 - 321 2016年06月 [査読有り][通常論文]
Background: Suicide rates have been related to educational level and other socioeconomic statuses. However, no prospective study has examined the association between educational level and the risk of suicide in Japan. Methods: We examined the association of education level and suicide risk in a population-based cohort of Japanese men and women aged 40-59 years in the Japan Public Health Center-based Prospective Study Cohort I. In the baseline survey initiated in 1990, a total of 46 156 subjects (21 829 men and 24 327 women) completed a self-administered questionnaire, which included a query of educational level, and were followed up until the end of December 2011. Educational levels were categorized into four groups (junior high school, high school, junior or career college, and university or higher education). During a median follow-up of 21.6 years, the hazard ratios (HRs) and 95% confidence intervals (CIs) of suicide according to educational level were estimated using the Cox proportional hazards regression model adjusted for age; study area; previous history of stroke, ischemic heart disease, or cancer; self-reported stress; alcohol consumption; smoking; living with spouse; and employment status. A total of 299 deaths attributed to suicide occurred. Results: The HR for university graduates or those with higher education versus junior high school graduates was 0.47 (95% CI, 0.24-0.94) in men, and that for high school graduates versus junior high school graduates was 0.44 (95% CI, 0.24-0.79) in women. Conclusions: High educational levels were associated with a reduced risk of suicide for both Japanese men and women.
書籍
講演・口頭発表等
- 新型コロナウイルス感染症に関する行政データと疫学研究データの結合：札幌市の事例を通じて [招待講演]木村尚史日本計算機統計学会第37回シンポジウム 2023年11月 シンポジウム・ワークショップパネル（指名）
- 木村尚史, 春原怜史, 堀幸, 細澤麻里子, 西條政幸, 磯博康, 玉腰暁子第82回日本公衆衛生学会学術総会 2023年11月 ポスター発表
- The linkage between administrative data and epidemiological research data: The Case of Sapporo City [招待講演]Takashi KimuraThe 33rd Annual Scientific Meeting of the Japan Epidemiological Association 2023年02月 シンポジウム・ワークショップパネル（指名）
- 札幌市における新型コロナウイルス感染症患者の特徴 [通常講演]木村尚史, 朝倉利晃, 黒鳥偉作, 春原怜史, 中西香織, 西條政幸, 玉腰暁子第33回日本疫学会総会 2023年02月 ポスター発表
- 札幌市における新型コロナウイルス感染症罹患後症状の実態 [通常講演]木村尚史, 朝倉利晃, 細澤麻里子, 堀幸, 中西香織, 磯博康, 玉腰暁子第81回日本公衆衛生学会 2022年10月 ポスター発表
- Risk of drowning: the Japan Collaborative Cohort (JACC) Study [通常講演]Takashi Kimura, Satoyo Ikehara, Hiroyasu Iso, Akiko Tamakoshi, for the JACC studyWorld Congress of Epidemiology 2021 2021年09月 ポスター発表
- JACC studyの概要 [通常講演]木村尚史コホート・生体試料支援プラットフォーム 令和２年度若手支援研究成果発表会 2021年02月 口頭発表（一般）
- 日本人地域一般住民における痩せ・肥満と腸内細菌叢との関連：The DOSANCO Health Study [通常講演]木村尚史, 山村凌大, 檜森亮吾, 鵜川重和, 中村幸志, 中川貴史, 今江章宏, 國弘忠生, 朴鐘旭, Attayeb Mohsen, 川島和, 清水由宇, 中村公則, 綾部時芳, 玉腰暁子第24回腸内細菌学会学術集会 2020年06月 ポスター発表
- エコチル調査大阪ユニットセンターにおける質問票回収に影響する要因の検討1 [通常講演]木村 尚史, 谷川 果菜美, 青地 ゆり, 池原 賢代, 佐藤 拓代, 磯 博康第28回日本疫学会総会 2018年02月 ポスター発表
その他活動・業績
- 田中 嘉き, 岡田 恵美子, 平田 匠, 木村 尚史, 玉腰 暁子 日本公衆衛生雑誌 70 (6) 359 -368 2023年06月目的 親が子どもに対して抱く情緒的絆の欠如をボンディング障害という。本研究では妊娠期の父親のパートナーへの関わりとボンディング障害の関連を検討する。方法 2016年5月～2017年12月に札幌市内の3つの産科病院を受診した妊婦とそのパートナー1,957組を対象とした。自記式質問票を妊娠24～35週と産後6～8週後に配布した。父親のパートナーへの関わりは,身の回りのことや家事の手伝い,相談にのっているかという2つの質問項目の5択の回答を0～4点で評価し,合計点が6～8点を高得点群,3～5点を中得点群,0～2点を低得点群とした。ボンディング障害は「赤ちゃんへの気持ち質問票」を用い,程度が高い上位約10%が含まれる点数をカットオフ値とした。妊娠期の父親のパートナーへの関わりを曝露,アウトカムをボンディング障害とし,ロジスティック回帰分析を行った。調整変数は父親の年齢,世帯年収,父親の一週間の平均労働時間,過去の妊娠,過去の流産や死産・子どもの死亡,パートナーの妊娠期抑うつとした。結果 回答を得られた父親は391人であり2回目の回答記入時期は産後2か月までが86.4%,3か月が10.6%,4か月が2.5%,5か月が1.0%であった。そのうち質問項目が欠損した者を除く375人を対象とした。父親のパートナーへの関わり高得点群は255人(68.0%),ボンディング障害は48人(7点以上,7.2%),下位尺度:lack of affection(LA)は35人(4点以上,9.3%),下位尺度:anger and rejection(AR)は17人(4点以上,4.5%)だった。多変量調整OR(95%CI)はパートナーへの関わり高得点群に対し,ボンディング障害は中得点群:4.81(1.88-12.33),低得点群:6.89(1.40-33.93),下位尺度LAは中得点群:2.21(0.97-5.04),低得点群:6.40(1.54-26.68)であった一方,下位尺度ARと有意な関連がみられなかった(trend Pは順に0.0005,0.0053,0.6859)。結論 妊娠期の父親のパートナーへの良好でない関わりが父親のボンディング障害と子どもへの愛情の欠如に影響することが考えられる。父親のボンディング障害の予防には妊娠期におけるパートナーへの関わりが重要であることが示唆された。(著者抄録)
- Xin Yin, Rie Kishida, Sarah Krull Abe, Md. Rashedul Islam, Md. Shafiur Rahman, Eiko Saito, Qing Lan, Batel Bletcher, Melissa Merritt, Ji-Yeob Choi, Aesun Shin, Ryoko Katagiri, Xiao-Ou Shu, Norie Sawada, Akiko Tamakoshi, Woon-Puay Koh, Ichiro Tsuji, Chisato Nagata, Sue K. Park, Sun-Seog Kweon, Yu-Tang Gao, Shoichiro Tsugane, Takashi Kimura, Jian-Min Yuan, Yukai Lu, Seiki Kanemura, Yumi Sugawara, Keiko Wada, Min-Ho Shin, Habibul Ahsan, Paolo Boffetta, Kee Seng Chia, Keitaro Matsuo, You-Lin Qiao, Nathaniel Rothman, Wei Zheng, Manami Inoue, Daehee Kang, Wei Jie Seow CANCER RESEARCH 83 (7) 2023年04月
- 和泉 裕久, 両角 麻衣, 田畑 風華, 川上 智美, 武田 安弘, 宮地 一裕, 中村 公則, 綾部 時芳, 中岡 慎治, 相沢 智康, 中村 宝弘, 木村 尚史, 中村 幸志, 玉腰 暁子 腸内細菌学雑誌 37 (2) 122 -122 2023年04月
- 両角 麻衣, 和泉 裕久, 田畑 風華, 川上 智美, 武田 安弘, 宮地 一裕, 中村 公則, 綾部 時芳, 中岡 慎治, 相沢 智康, 中村 宝弘, 木村 尚史, 中村 幸志, 玉腰 暁子 腸内細菌学雑誌 37 (2) 123 -123 2023年04月
- 低炭水化物食スコアと糖代謝指標との関連八重樫 昭徳, 木村 尚史, 岡田 恵美子, 中村 幸志, 鵜川 重和, 中村 昭伸, 玉腰 暁子 日本栄養・食糧学会大会講演要旨集 77回 328 -328 2023年03月
- 札幌市における新型コロナウイルス感染症患者の特徴木村 尚史, 朝倉 利晃, 黒鳥 偉作, 春原 怜史, 中西 香織, 西條 政幸, 玉腰 暁子 Journal of Epidemiology 33 (Suppl.1) 111 -111 2023年02月
- 顎顔面の形態や機能が小児の睡眠の質に与える影響について黒坂 寛, 木村 尚史, 白石 優季, 長田 奈幹, 山本 沙優里, 池原 賢代, 磯 博康, 山城 隆 日本公衆衛生学会総会抄録集 81回 388 -388 2022年09月
- 札幌市における新型コロナウイルス感染症罹患後症状の実態木村 尚史, 朝倉 利晃, 細澤 麻里子, 堀 幸, 中西 香織, 磯 博康, 玉腰 暁子 日本公衆衛生学会総会抄録集 81回 453 -453 2022年09月
- COVID-19における発症から陽性確定の遅れに関連する患者要因の分析綿貫 大智, 朝倉 利晃, 木村 尚史, 中西 香織, 玉腰 暁子 日本公衆衛生学会総会抄録集 81回 456 -456 2022年09月
- 方波見 謙一, 木村 尚史, 玉腰 暁子 日本在宅救急医学会誌 5 (2) 1 -7 2022年03月【目的】平成30年北海道胆振東部地震に伴った停電における、札幌市在宅人工呼吸器患者への対応の実態と入院となったリスク要因を検討する。【方法】札幌市在宅医療協議会所属会員を対象として行われたアンケート調査を利用し、本研究を行った。【結果】札幌市内の在宅人工呼吸器患者数は230名であった。使用時間が常時(24時間)であれば入院に対するPR(prevalence ratio)は9.07(95%CI:5.10〜16.10、p<.0001)、人工呼吸器設定についてはTPPV(tracheostomy positive pressure ventilation)の場合、TPPVではない場合に比べ入院に対するPRは3.57(95%CI:2.29〜5.55、p<.0001)であった。年齢と使用時間による多変量解析では、使用時間のPRが9.21(95%CI:5.17〜16.39、p<.0001)であった。入院とならなかった患者は147名であり、入院回避の理由として、電源が確保できたが87名(59.2%)で、自家用車からの電源確保が35名(40.2%)であった。【結語】災害に伴った停電時には在宅人工呼吸器24時間使用は入院のリスクとなる。リスクが高い患者において日ごろから自家用車などの非常電源を確保しておくことが、災害急性期の停電対策として重要である。(著者抄録)
- KUROTORI Isaku, KIMURA Takashi, SASAO Wataru, ABE Masahiko, KUMAGAI Hideki, TAMAKOSHI Akiko 日本プライマリ・ケア連合学会学術大会(Web) 13th 2022年
- 地域在住高齢者における歩行と認知機能の関連 横断研究(Association of gait with cognitive function among community-dwelling older adults: a cross-sectional study)Hao Wen, Zhao Wenjing, Kimura Takashi, Ukawa Shigekazu, Kadoya Ken, Kondo Katsunori, Tamakoshi Akiko Journal of Epidemiology 32 (Suppl.1) 92 -92 2022年01月
- 気道異物による死亡のリスク因子 日本多施設共同コホート研究(Risk Factors of Mortality from Foreign Bodies in the Respiratory Tract: The Japan Collaborative Cohort Study)Katabami Kenichi, Kimura Takashi, Hirata Takumi, Tamakoshi Akiko Journal of Epidemiology 32 (Suppl.1) 154 -154 2022年01月
- COVID-19に対する経済的影響を加味した世代別のワクチン優先接種戦略春原 怜史, 朝倉 利晃, 木村 尚史, 小澤 隼, 大島 慧士, 山内 大瑚, 玉腰 暁子 Journal of Epidemiology 32 (Suppl.1) 118 -118 2022年01月
- スクリーンタイムが肥満に及ぼす影響若狭 はな, 木村 尚史, 平田 匠, 玉腰 暁子 日本公衆衛生学会総会抄録集 80回 369 -369 2021年11月
- 産前における夫婦関係と父親のボンディング障害との関連田中 嘉き, 岡田 恵美子, 平田 匠, 木村 尚史, 玉腰 暁子 日本公衆衛生学会総会抄録集 80回 386 -386 2021年11月
- 緑茶とうつとの関連 観察研究のシステマティックレビューとメタアナリシス八重樫 昭徳, 木村 尚史, 平田 匠, 玉腰 暁子 日本公衆衛生学会総会抄録集 80回 473 -473 2021年11月
- 札幌市におけるCOVID-19のリアルタイムデータ収集、分析、共有(Real-time data collection, analysis and sharing for COVID-19 in Sapporo City)Ozawa Shun, Asakura Toshiaki, Sunohara Satoshi, Oshima Satoshi, Yamauchi Daigo, Kimura Takashi, Nakanishi Kaori, Tamakoshi Akiko 日本公衆衛生学会総会抄録集 80回 314 -314 2021年11月
- 地域在住高齢者における不眠と口腔関連QOLの関係(CHEER Iwamizawa)渡邊 裕, 三浦 和仁, 馬場 陽久, 近藤 美弥子, 松下 貴恵, 岡田 和隆, 山崎 裕, 齋藤 博, 木村 尚史, 玉腰 暁子 睡眠口腔医学 8 (総会特別号) 54 -54 2021年11月
- 高齢者におけるたんぱく質摂取量と骨格筋量及び除脂肪量との関連 システマティックレビュー八重樫 昭徳, 木村 尚史, 平田 匠, 玉腰 暁子 日本サルコペニア・フレイル学会雑誌 5 (Suppl.) 216 -216 2021年10月
- Saeka Takabayashi, Takumi Hirata, Wenjing Zhao, Takashi Kimura, Shigekazu Ukawa, Kazuyo Tsushita, Kenji Wakai, Takashi Kawamura, Masahiko Ando, Akiko Tamakoshi INTERNATIONAL JOURNAL OF EPIDEMIOLOGY 50 2021年09月
- 藤井 仁, 湯川 慶子, 新井 一郎, 児玉 知子, 木村 尚史 Therapeutic Research 42 (6) 423 -429 2021年06月目的:2020年の改正食品衛生法で定められた4つの指定成分を含む健康食品が薬局でどの程度流通しているのか、特に取り扱いが多い薬局の特徴は何か、薬局でどの程度指定成分等含有食品のことが知られているかを明らかにすることを目的とする。方法:調査会社を通じて全国の薬局名簿から完全無作為に抽出した薬局1000店舗の仕入れ担当者に調査票を郵送し、(1)健康食品を取り扱っているか、(2)指定成分等含有食品が4つ定められる予定であることを知っているか、(3)4つの指定成分等含有食品が何かを知っているか、(4)4つの指定成分等含有食品を過去に取り扱ったことがあるか、(5)4つの指定成分等含有食品を今販売しているか、(6)今後、4つの指定成分等含有食品の取り扱いを続けるか、止めるか、(7)新たに既存の健康食品が指定成分等含有食品に指定されたらどのような対応をとるか、などについて質問した。結果:183の薬局からの回答を分析対象とした。有効回答率18.3%であった。制度自体の認知度、健康被害の報告義務、4つの指定成分等含有食品の名称、過去に生じた健康被害等についての認知度は非常に低かった。また、501社以上の規模をもつ大手チェーン店とネット販売をしている業者で認知度が高かった。結論:指定成分等含有食品の認知度は非常に低かったが、指定成分等含有食品が健康被害を生じさせうる商品であり、健康被害が生じた際には報告の義務が課されることを認識したうえで販売を続けようとする担当者はおらず、適切な情報提供によって販売を自制させることができると考えられた。また、ネット販売をしている薬局では指定成分等含有食品の認知度が高く、これらの業者は実店舗では販売しないがネットを介して販売している可能性があり、注意喚起が必要であると考えられる。(著者抄録)
- 地域住民における喫煙(新型タバコを含む)と抑うつ症状との関連柏倉 揚子, 木村 尚史, 玉腰 暁子 Journal of Epidemiology 31 (Suppl.1) 121 -121 2021年01月
- 女性は男性よりも身体活動量が少ないか DOSANCO Health Study天笠 志保, 井上 茂, 鵜川 重和, 佐々木 幸子, 中村 幸志, 吉村 彩, 田中 綾, 木村 尚史, 中川 貴史, 今江 章宏, Ding Ding, 菊池 宏幸, 玉腰 暁子 Journal of Epidemiology 31 (Suppl.1) 127 -127 2021年01月
- 寒冷積雪地の地域在住高齢者における加速度計による身体活動量と転倒との関連小島 令嗣, 鵜川 重和, 横道 洋司, 田中 綾, 木村 尚史, 天笠 志保, 井上 茂, 近藤 克則, 玉腰 暁子 Journal of Epidemiology 31 (Suppl.1) 134 -134 2021年01月
- 北海道内の二次医療圏単位にみた大腸がん発見に関する研究高橋 祥, 木村 尚史, 玉腰 暁子 日本公衆衛生学会総会抄録集 79回 240 -240 2020年10月
- 覚せい剤依存症患者の特徴と治療予後の関連山本 泰輔, 木村 尚史, 玉腰 暁子, 松本 俊彦 日本公衆衛生学会総会抄録集 79回 267 -267 2020年10月
- 妊婦の自閉症傾向特性の特徴について 子どもの健康と環境に関する全国調査廣川 空美, 木村 尚史, 池原 賢代, 本庄 かおり, 植田 紀美子, 佐藤 拓代, 磯 博康 日本公衆衛生学会総会抄録集 79回 360 -360 2020年10月
- 地域在住日本人高齢者におけるたんぱく質摂取量と骨格筋量、筋肉量、握力との関連八重樫 昭徳, 木村 尚史, 平田 匠, 岡田 恵美子, 中村 幸志, 鵜川 重和, 玉腰 暁子 日本公衆衛生学会総会抄録集 79回 468 -468 2020年10月
- 新型コロナウイルス感染症情報の効率的な把握・提供・共有のための北海道における取り組み玉腰 暁子, 朝倉 利晃, 木村 尚史, 平田 匠, 人見 嘉哲, 中瀬 克己 病原微生物検出情報月報 41 (5) 86 -87 2020年05月 [査読無し][通常論文]
- 情報入力用ファイルと集計用GUIアプリを用いた日常業務内における新型コロナウイルス感染症情報の把握例の紹介情報入力用ファイルと集計用GUIアプリを用いた日常業務内における新型コロナウイルス感染症情報の把握例の紹介木村尚史, 朝倉利晃, 玉腰暁子, 人見嘉哲, 山口亮 Infectious Agents Surveillance Report 41 87 -88 2020年05月 [査読無し][通常論文]
- 山村 凌大, 鵜川 重和, 中村 幸志, 木村 尚史, 中川 貴史, 今江 章宏, 國弘 忠生, 朴 鐘旭, Mohsen Attayeb, 川島 和, 清水 由宇, 中村 公則, 綾部 時芳, 玉腰 暁子 腸内細菌学雑誌 34 (2) 107 -107 2020年04月
- 山村 凌大, 鵜川 重和, 中村 幸志, 木村 尚史, 中川 貴史, 今江 章宏, 國弘 忠生, 朴 鐘旭, Mohsen Attayeb, 川島 和, 清水 由宇, 中村 公則, 綾部 時芳, 玉腰 暁子 腸内細菌学雑誌 34 (2) 107 -107 2020年04月
- 消費者向け媒体における健康食品に関する注意喚起の伝達状況分析 雑誌見島 亜莉沙, 溝口 貴文, 新井 一郎, 三澤 仁平, 木村 尚史, 湯川 慶子, 児玉 知子, 藤井 仁 日本薬学会年会要旨集 140年会 27P -pm009S 2020年03月
- 消費者向け媒体における健康食品に関する注意喚起の伝達状況分析 新聞・ネット販売サイト溝口 貴文, 見島 亜莉沙, 新井 一郎, 三澤 仁平, 木村 尚史, 湯川 慶子, 児玉 知子, 藤井 仁 日本薬学会年会要旨集 140年会 27P -pm010S 2020年03月
- YAMAMURA Ryodai, NAKAMURA Koshi, NAKAMURA Koshi, KITADA Naoya, AIZAWA Tomoyasu, SHIMIZU Yu, NAKAMURA Kiminori, AYABE Tokiyoshi, KIMURA Takashi, TAMAKOSHI Akiko 日本細菌学雑誌(Web) 75 (1) 2020年
- 腸内細菌叢、食事摂取量、血清SCFAsと大便中SCFAsの関連性(Associations of gut microbiota, dietary intake, and serum SCFAs with fecal SCFAs)山村 凌大, 中村 幸志, 北田 直也, 相沢 智康, 清水 由宇, 中村 公則, 綾部 時芳, 木村 尚史, 玉腰 暁子 日本細菌学雑誌 75 (1) 70 -70 2020年01月
- 居住形態と産後うつ傾向の関連 子どもの健康と環境に関する全国調査(エコチル調査)本庄 かおり, 木村 尚史, 池原 賢代, 馬場 幸子, 北野 尚美, 佐藤 拓代, 磯 博康 日本公衆衛生学会総会抄録集 78回 228 -228 2019年10月
- 過去に健康被害を生じさせた健康食品に関する情報発信の課題と対策藤井 仁, 木村 尚史, 三澤 仁平 日本公衆衛生学会総会抄録集 78回 567 -567 2019年10月
- 谷川果菜美, 木村尚史, 池原賢代, 池原賢代, 董加毅, 崔美善, 青地ゆり, 植田紀美子, 磯博康 日本疫学会学術総会講演集(Web) 29th 2019年
- 妊婦の喫煙及び飲酒 エコチル調査大阪ユニットセンターでの状況池原 賢代, 木村 尚史, 柿ヶ野 藍子, 佐藤 拓代, 磯 博康 日本公衆衛生学会総会抄録集 77回 372 -372 2018年10月
- エコチル調査大阪ユニットセンターにおける質問票回収に影響する要因の検討崔 美善, 木村 尚史, 董 加毅, 池原 賢代, 植田 紀美子, 磯 博康 日本公衆衛生学会総会抄録集 77回 380 -380 2018年10月
- 青地ゆり, 木村尚史, 谷川果菜美, 池原賢代, 池原賢代, 佐藤拓代, 磯博康 日本疫学会学術総会講演集(Web) 28th 2018年
- 女性の生殖歴と循環器疾患死亡リスクとの関連 The JACC study谷川 果菜美, 磯 博康, 木村 尚史, 池原 賢代, 玉腰 暁子 日本公衆衛生学会総会抄録集 76回 291 -291 2017年10月
- 大阪ユニットセンターの活動磯 博康, 佐藤 拓代, 池原 賢代, 山崎 不二子, 木村 尚史 チャイルドヘルス 19 (7) 526 -527 2016年 [査読無し][通常論文]
共同研究・競争的資金等の研究課題
- 混合研究法による積雪寒冷地において冬季身体活動量低下を防止するプログラムの検討日本学術振興会：科学研究費助成事業 基盤研究(B)研究期間 : 2020年04月 -2024年03月代表者 : 玉腰 暁子, 木村 尚史, 佐々木 幸子
- 厚生労働省：厚生労働科学研究費補助金特別研究事業研究期間 : 2021年07月 -2022年03月代表者 : 木村尚史, 玉腰暁子, 西條政幸
- 北海道における新型コロナウイルス感染症の重症化・死亡リスクに関する分析北海道大学：次世代研究者リーダー育成共同研究助成研究期間 : 2021年06月 -2022年03月代表者 : 木村尚史
- 科学的根拠に基づくがんリスク評価とがん予防ガイドライン提言に関する研究国立研究開発法人 国立がん研究センター：年度国立がん研究センター運営費交付金研究開発費研究期間 : 2021年04月
- 健康食品等の安全確保に必要な技術的課題への対応と効果的な情報発信のための研究厚生労働科学研究費代表者 : 藤井仁, 湯川慶子, 新井一郎, 木村尚史, 三澤仁平
教育活動情報
主要な担当授業
- 大学院共通授業科目（教育プログラム）：社会と健康開講年度 : 2021年課程区分 : 修士課程開講学部 : 大学院共通科目キーワード : 解析ソフトウェア、SAS、疫学データ
- 応用疫学開講年度 : 2021年課程区分 : 修士課程開講学部 : 医学院キーワード : 解析ソフトウェア、SAS、疫学データ
- 大学院共通授業科目（教育プログラム）：社会と健康開講年度 : 2021年課程区分 : 修士課程開講学部 : 大学院共通科目キーワード : エビデンス・ベースド・メディスン（EBM）、疑問の定式化、論文検索、批判的吟味
- 大学院共通授業科目（教育プログラム）：社会と健康開講年度 : 2021年課程区分 : 修士課程開講学部 : 大学院共通科目
- 応用疫学開講年度 : 2021年課程区分 : 修士課程開講学部 : 医学院キーワード : エビデンス・ベースド・メディスン（EBM）、疑問の定式化、論文検索、批判的吟味
- 応用疫学開講年度 : 2021年課程区分 : 修士課程開講学部 : 医学院
- 基本公衆衛生学研究開講年度 : 2021年課程区分 : 修士課程開講学部 : 医学院キーワード : 公衆衛生、疫学、予防医学
- 基本医学研究開講年度 : 2021年課程区分 : 修士課程開講学部 : 医学院キーワード : 公衆衛生、疫学、予防医学
- 基本医学総論開講年度 : 2021年課程区分 : 修士課程開講学部 : 医学院キーワード : 公衆衛生学、予防医学、疫学、地域保健、母子保健、高齢者保健
- 基礎疫学開講年度 : 2021年課程区分 : 修士課程開講学部 : 医学院
- 社会医学研究法Ⅰ開講年度 : 2021年課程区分 : 博士後期課程開講学部 : 医学院
- 医学総論開講年度 : 2021年課程区分 : 博士後期課程開講学部 : 医学院キーワード : 公衆衛生学、予防医学、疫学、地域保健、母子保健、高齢者保健
- 基盤医学研究開講年度 : 2021年課程区分 : 博士後期課程開講学部 : 医学院キーワード : 公衆衛生、疫学、予防医学
- 社会医学研究開講年度 : 2021年課程区分 : 博士後期課程開講学部 : 医学院キーワード : 公衆衛生、疫学、予防医学
- 社会医学実習開講年度 : 2021年課程区分 : 学士課程開講学部 : 医学部
- 公衆衛生学開講年度 : 2021年課程区分 : 学士課程開講学部 : 医学部キーワード : 公衆衛生学・予防医学・疫学・地域保健・母子保健・高齢者保健