瀬谷 司セヤ ツカサresearchmap個人ページ

更新日 : 2017/09/19

基本情報

プロフィール

所属部署名
医学研究院  
職名特任教授 
学位
医学博士(北海道大学)
薬学博士(北海道大学)
メールアドレス
ホームページURLhttp://www.med.hokudai.ac.jp/~bac-w/
科研費研究者番号

研究キーワード

免疫学, ウイルス学, がん免疫

研究分野

基礎医学 / 免疫学
基礎医学 / ウイルス学
内科系臨床医学 / 膠原病・アレルギー内科学
研究分野を全て表示する
研究分野閉じる
基礎医学 / 免疫学
基礎医学 / ウイルス学
内科系臨床医学 / 膠原病・アレルギー内科学

職歴

2006年
-
2009年
 北海道大学先端生命科学研究院 教授
2004年
-
2007年
 大阪府立成人病センター研究所 研究員
2005年
-
2007年
 東京大学医学研究科非常勤講師(併任) 講師
2005年
-
2006年
 京都大学ウイルス研究所客員教授 教授
1998年
-
2004年
 奈良先端大学院大学客員教授 教授
2001年
-
2004年
 大阪府立成人病センター研究所 所長
2003年
-
2004年
 大阪大学医学研究科客員教授 教授
1998年
-
2001年
 大阪府立成人病センター研究所 免疫部門 部長
1987年
-
1998年
 大阪府立成人病センター研究所免疫部門 室長
1984年
-
1987年
 米国ワシントン大学(セントルイス)微生物・免疫学講座 研究員
職歴を全て表示する
職歴閉じる
2006年
-
2009年
 北海道大学先端生命科学研究院 教授
2004年
-
2007年
 大阪府立成人病センター研究所 研究員
2005年
-
2007年
 東京大学医学研究科非常勤講師(併任) 講師
2005年
-
2006年
 京都大学ウイルス研究所客員教授 教授
1998年
-
2004年
 奈良先端大学院大学客員教授 教授
2001年
-
2004年
 大阪府立成人病センター研究所 所長
2003年
-
2004年
 大阪大学医学研究科客員教授 教授
1998年
-
2001年
 大阪府立成人病センター研究所 免疫部門 部長
1987年
-
1998年
 大阪府立成人病センター研究所免疫部門 室長
1984年
-
1987年
 米国ワシントン大学(セントルイス)微生物・免疫学講座 研究員
1979年
-
1984年
 北海道大学薬学部 衛生化学部門 研究生
1976年
-
1979年
 北海道大学医学部附属病院1内科 医員
2004年
- 北海道大学大学院医学研究科免疫学分野 教授
2009年
- 北海道大学大学院医学研究科免疫学分野 教授

学歴

北海道大学 薬学部 学位取得終了(S59)
北海道大学 医学部 卒(S51)
学歴を全て表示する
学歴閉じる
北海道大学 薬学部 学位取得終了(S59)
北海道大学 医学部 卒(S51)

所属学協会

日本分子生物学会
日本免疫学会
日本エンドトキシン研究会
日本生化学会
日本がん免疫学会
日本ウィルス学会
日本癌学会
日本インターフェロン・サイトカイン学会
日本生体防御学会
バイオ治療法研究会
所属学協会を全て表示する
所属学協会閉じる
日本分子生物学会
日本免疫学会
日本エンドトキシン研究会
日本生化学会
日本がん免疫学会
日本ウィルス学会
日本癌学会
日本インターフェロン・サイトカイン学会
日本生体防御学会
バイオ治療法研究会

研究活動

論文

The J6JFH1 Strain of Hepatitis C Virus Infects Human B-Cells with Low Replication Efficacy.
Nakai M, Seya T, Matsumoto M, Shimotohno K, Sakamoto N, Aly HH
Viral immunology 27 285-294 2014年08月
Measles Virus Takes a Two-Pronged Attack on PP1.
Seya T
Cell host & microbe 16 1-2 2014年07月
Dendritic cell subsets involved in type I IFN induction in mouse measles virus infection models.
Takaki H, Oshiumi H, Matsumoto M, Seya T
The international journal of biochemistry & cell biology 53C 329-333 2014年06月
The N-terminal domain of TIR domain-containing adaptor molecule-1, TICAM-1.
Kumeta H, Sakakibara H, Enokizono Y, Ogura K, Horiuchi M, Matsumoto M, Seya T, Inagaki F
Journal of biomolecular NMR 58 227-230 2014年03月
Beyond dsRNA: Toll-like receptor 3 signalling in RNA-induced immune responses.
Tatematsu M, Seya T, Matsumoto M
The Biochemical journal 458 195-201 2014年03月
IPS-1 is essential for type III IFN production by hepatocytes and dendritic cells in response to hepatitis C virus infection.
Okamoto M, Oshiumi H, Azuma M, Kato N, Matsumoto M, Seya T
Journal of immunology (Baltimore, Md. : 1950) 192 2770-2777 2014年03月
MAVS-dependent IRF3/7 bypass of interferon β-induction restricts the response to measles infection in CD150Tg mouse bone marrow-derived dendritic cells.
Takaki H, Honda K, Atarashi K, Kobayashi F, Ebihara T, Oshiumi H, Matsumoto M, Shingai M, Seya T
Molecular immunology 57 100-110 2014年02月
Myeloid-derived suppressor cells confer tumor-suppressive functions on natural killer cells via polyinosinic:polycytidylic acid treatment in mouse tumor models.
Shime H, Kojima A, Maruyama A, Saito Y, Oshiumi H, Matsumoto M, Seya T
Journal of innate immunity 6 293-305 2014年
Assessment of the Toll-like receptor 3 pathway in endosomal signaling.
Matsumoto M, Funami K, Tatematsu M, Azuma M, Seya T
Methods in enzymology 535 149-165 2014年
Structures and interface mapping of the TIR domain-containing adaptor molecules involved in interferon signaling.
Enokizono Y, Kumeta H, Funami K, Horiuchi M, Sarmiento J, Yamashita K, Standley DM, Matsumoto M, Seya T, Inagaki F
Proceedings of the National Academy of Sciences of the United States of America 110 19908-19913 2013年12月
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The J6JFH1 Strain of Hepatitis C Virus Infects Human B-Cells with Low Replication Efficacy.
Nakai M, Seya T, Matsumoto M, Shimotohno K, Sakamoto N, Aly HH
Viral immunology 27 285-294 2014年08月
Measles Virus Takes a Two-Pronged Attack on PP1.
Seya T
Cell host & microbe 16 1-2 2014年07月
Dendritic cell subsets involved in type I IFN induction in mouse measles virus infection models.
Takaki H, Oshiumi H, Matsumoto M, Seya T
The international journal of biochemistry & cell biology 53C 329-333 2014年06月
The N-terminal domain of TIR domain-containing adaptor molecule-1, TICAM-1.
Kumeta H, Sakakibara H, Enokizono Y, Ogura K, Horiuchi M, Matsumoto M, Seya T, Inagaki F
Journal of biomolecular NMR 58 227-230 2014年03月
Beyond dsRNA: Toll-like receptor 3 signalling in RNA-induced immune responses.
Tatematsu M, Seya T, Matsumoto M
The Biochemical journal 458 195-201 2014年03月
IPS-1 is essential for type III IFN production by hepatocytes and dendritic cells in response to hepatitis C virus infection.
Okamoto M, Oshiumi H, Azuma M, Kato N, Matsumoto M, Seya T
Journal of immunology (Baltimore, Md. : 1950) 192 2770-2777 2014年03月
MAVS-dependent IRF3/7 bypass of interferon β-induction restricts the response to measles infection in CD150Tg mouse bone marrow-derived dendritic cells.
Takaki H, Honda K, Atarashi K, Kobayashi F, Ebihara T, Oshiumi H, Matsumoto M, Shingai M, Seya T
Molecular immunology 57 100-110 2014年02月
Myeloid-derived suppressor cells confer tumor-suppressive functions on natural killer cells via polyinosinic:polycytidylic acid treatment in mouse tumor models.
Shime H, Kojima A, Maruyama A, Saito Y, Oshiumi H, Matsumoto M, Seya T
Journal of innate immunity 6 293-305 2014年
Assessment of the Toll-like receptor 3 pathway in endosomal signaling.
Matsumoto M, Funami K, Tatematsu M, Azuma M, Seya T
Methods in enzymology 535 149-165 2014年
Structures and interface mapping of the TIR domain-containing adaptor molecules involved in interferon signaling.
Enokizono Y, Kumeta H, Funami K, Horiuchi M, Sarmiento J, Yamashita K, Standley DM, Matsumoto M, Seya T, Inagaki F
Proceedings of the National Academy of Sciences of the United States of America 110 19908-19913 2013年12月
The MyD88 pathway in plasmacytoid and CD4+ dendritic cells primarily triggers type I IFN production against measles virus in a mouse infection model.
Takaki H, Takeda M, Tahara M, Shingai M, Oshiumi H, Matsumoto M, Seya T
Journal of immunology (Baltimore, Md. : 1950) 191 4740-4747 2013年11月
Herpesvirus 6 glycoproteins B (gB), gH, gL, and gQ are necessary and sufficient for cell-to-cell fusion.
Tanaka Y, Suenaga T, Matsumoto M, Seya T, Arase H
Journal of virology 87 10900-10903 2013年10月
Hepatitis C virus infection induces inflammatory cytokines and chemokines mediated by the cross talk between hepatocytes and stellate cells.
Nishitsuji H, Funami K, Shimizu Y, Ujino S, Sugiyama K, Seya T, Takaku H, Shimotohno K
Journal of virology 87 8169-8178 2013年07月
Targeting TLR3 with no RIG-I/MDA5 activation is effective in immunotherapy for cancer.
Seya T, Azuma M, Matsumoto M
Expert opinion on therapeutic targets 17 533-544 2013年05月
Multi-step regulation of interferon induction by hepatitis C virus.
Oshiumi H, Funami K, Aly HH, Matsumoto M, Seya T
Archivum immunologiae et therapiae experimentalis 61 127-138 2013年04月
[Innate immune responses against viral infection and its suppression by viral proteins].
Oshiumi H, Matsumoto M, Seya T
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 133 323-328 2013年
Toll-IL-1-receptor-containing adaptor molecule-1: a signaling adaptor linking innate immunity to adaptive immunity.
Matsumoto M, Funami K, Oshiumi H, Seya T
Progress in molecular biology and translational science 117 487-510 2013年
Toll-like receptor 3 recognizes incomplete stem structures in single-stranded viral RNA.
Tatematsu M, Nishikawa F, Seya T, Matsumoto M
Nature communications 4 1833 2013年
A distinct role of Riplet-mediated K63-Linked polyubiquitination of the RIG-I repressor domain in human antiviral innate immune responses.
Oshiumi H, Miyashita M, Matsumoto M, Seya T
PLoS pathogens 9 e1003533 2013年
Cell type-specific subcellular localization of phospho-TBK1 in response to cytoplasmic viral DNA.
Suzuki T, Oshiumi H, Miyashita M, Aly HH, Matsumoto M, Seya T
PloS one 8 e83639 2013年
Dendritic Cells from Oral Cavity Induce Foxp3+ Regulatory T Cells upon Antigen Stimulation
Yamazaki S, Maruyama A, Okada K, Matsumoto M, Morita A, Seya T
PLoS ONE 7(12) e51665-e51665 2012年12月
Guideline for Hereditary Angioedema (HAE) 2010 by the Japanese Association for Complement Research - Secondary Publication.
Horiuchi T, Ohi H, Ohsawa I, Fujita T, Matsushita M, Okada N, Seya T, Yamamoto T, Endo Y, Hatanaka M, Wakamiya N, Mizuno M, Nakao M, Okada H, Tsukamoto H, Matsumoto M, Inoue N, Nonaka M, Kinoshita T
Allergology international : official journal of the Japanese Society of Allergology 61(4) 559-562 2012年12月
Cleaved/Associated TLR3 Represents the Primary Form of the Signaling Receptor.
Toscano F, Estornes Y, Virard F, Garcia-Cattaneo A, Pierrot A, Vanbervliet B, Bonnin M, Ciancanelli MJ, Zhang SY, Funami K, Seya T, Matsumoto M, Pin JJ, Casanova JL, Renno T, Lebecque S
Journal of immunology (Baltimore, Md. : 1950) 2012年12月
TLR3/TICAM-1 signaling in tumor cell RIP3-dependent necroptosis.
Seya T, Shime H, Takaki H, Azuma M, Oshiumi H, Matsumoto M
Oncoimmunology 1 917-923 2012年09月
TAMable tumor-associated macrophages in response to innate RNA sensing.
Seya T, Shime H, Matsumoto M
Oncoimmunology 1 1000-1001 2012年09月
Cross-priming for antitumor CTL induced by soluble Ag + polyI:C depends on the TICAM-1 pathway in mouse CD11c(+)/CD8α(+) dendritic cells.
Azuma M, Ebihara T, Oshiumi H, Matsumoto M, Seya T
Oncoimmunology 1 581-592 2012年08月
[Role of ubiquitin ligase in innate immune response in mammal].
Oshiumi H, Matsumoto M, Seya T
Seikagaku. The Journal of Japanese Biochemical Society 84 455-462 2012年06月
Toll-like receptor 3 signaling converts tumor-supporting myeloid cells to tumoricidal effectors.
Shime H, Matsumoto M, Oshiumi H, Tanaka S, Nakane A, Iwakura Y, Tahara H, Inoue N, Seya T
Proceedings of the National Academy of Sciences of the United States of America 109 2066-2071 2012年02月
Ubiquitin-mediated modulation of the cytoplasmic viral RNA sensor RIG-I.
Oshiumi H, Matsumoto M, Seya T
Journal of biochemistry 151 5-11 2012年01月
The toll-like receptor 3-mediated antiviral response is important for protection against poliovirus infection in poliovirus receptor transgenic mice.
Abe Y, Fujii K, Nagata N, Takeuchi O, Akira S, Oshiumi H, Matsumoto M, Seya T, Koike S
Journal of virology 86 185-194 2012年01月
In vitro models for analysis of the hepatitis C virus life cycle.
Aly HH, Shimotohno K, Hijikata M, Seya T
Microbiology and immunology 56 1-9 2012年01月
Dendritic cells from oral cavity induce Foxp3(+) regulatory T cells upon antigen stimulation.
Yamazaki S, Maruyama A, Okada K, Matsumoto M, Morita A, Seya T
PloS one 7 e51665 2012年
Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency.
Sancho-Shimizu V, Pérez de Diego R, Lorenzo L, Halwani R, Alangari A, Israelsson E, Fabrega S, Cardon A, Maluenda J, Tatematsu M, Mahvelati F, Herman M, Ciancanelli M, Guo Y, AlSum Z, Alkhamis N, Al-Makadma AS, Ghadiri A, Boucherit S, Plancoulaine S, Picard C, Rozenberg F, Tardieu M, Lebon P, Jouanguy E, Rezaei N, Seya T, Matsumoto M, Chaussabel D, Puel A, Zhang SY, Abel L, Al-Muhsen S, Casanova JL
The Journal of clinical investigation 121 4889-4902 2011年12月
[Innate immune response to RNA virus infection].
Oshiumi H, Matsumoto M, Seya T
Uirusu 61 153-161 2011年12月
The TLR3/TICAM-1 pathway is mandatory for innate immune responses to poliovirus infection.
Oshiumi H, Okamoto M, Fujii K, Kawanishi T, Matsumoto M, Koike S, Seya T
Journal of immunology (Baltimore, Md. : 1950) 187 5320-5327 2011年11月
DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling.
Miyashita M, Oshiumi H, Matsumoto M, Seya T
Molecular and cellular biology 31 3802-3819 2011年09月
Will there be an HCV meeting in 2020? Summary of the 17th international meeting on hepatitis C virus and related viruses.
Wakita T, Suzuki T, Evans MJ, Shimotohno K, Chayama K, Matsuura Y, Hijikata M, Moriishi K, Seya T, Enomoto N, Koike K, Kato N, Kanto T, Hotta H
Gastroenterology 141 e1-5 2011年07月
Addendum to "Strain-to-strain difference of V protein of measles virus affects MDA5-mediated IFN-β-inducing potential" [Mol. Immunol. 48(4) (2011) 497-504].
Seya T
Molecular immunology 48 1589-1590 2011年07月
Natural killer cells recognize friend retrovirus-infected erythroid progenitor cells through NKG2D-RAE-1 interactions In Vivo.
Ogawa T, Tsuji-Kawahara S, Yuasa T, Kinoshita S, Chikaishi T, Takamura S, Matsumura H, Seya T, Saga T, Miyazawa M
Journal of virology 85 5423-5435 2011年06月
Development of monoclonal antibodies that specifically interact with necrotic lymphoma cells.
Wakasa K, Shime H, Kurita-Taniguchi M, Matsumoto M, Imamura M, Seya T
Microbiology and immunology 55 373-377 2011年05月
Failure of mycoplasma lipoprotein MALP-2 to induce NK cell activation through dendritic cell TLR2.
Sawahata R, Shime H, Yamazaki S, Inoue N, Akazawa T, Fujimoto Y, Fukase K, Matsumoto M, Seya T
Microbes and infection / Institut Pasteur 13 350-358 2011年04月
TLR2-dependent induction of IL-10 and Foxp3+ CD25+ CD4+ regulatory T cells prevents effective anti-tumor immunity induced by Pam2 lipopeptides in vivo.
Yamazaki S, Okada K, Maruyama A, Matsumoto M, Yagita H, Seya T
PloS one 6 e18833 2011年04月
Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation.
Watanabe A, Tatematsu M, Saeki K, Shibata S, Shime H, Yoshimura A, Obuse C, Seya T, Matsumoto M
The Journal of biological chemistry 286 10702-10711 2011年03月
Antiviral responses induced by the TLR3 pathway.
Matsumoto M, Oshiumi H, Seya T
Reviews in medical virology 2011年02月
Strain-to-strain difference of V protein of measles virus affects MDA5-mediated IFN-β-inducing potential.
Takaki H, Watanabe Y, Shingai M, Oshiumi H, Matsumoto M, Seya T
Molecular immunology 48 497-504 2011年01月
IL-23-dependent and -independent enhancement pathways of IL-17A production by lactic acid.
Yabu M, Shime H, Hara H, Saito T, Matsumoto M, Seya T, Akazawa T, Inoue N
International immunology 23 29-41 2011年01月
Natural killer cell activation secondary to innate pattern sensing.
Seya T, Kasamatsu J, Azuma M, Shime H, Matsumoto M
Journal of innate immunity 3 264-273 2011年
Development of mouse hepatocyte lines permissive for hepatitis C virus (HCV).
Aly HH, Oshiumi H, Shime H, Matsumoto M, Wakita T, Shimotohno K, Seya T
PloS one 6 e21284 2011年
Phosphoinositide 3-kinaseγ controls the intracellular localization of CpG to limit DNA-PKcs-dependent IL-10 production in macrophages.
Hazeki K, Kametani Y, Murakami H, Uehara M, Ishikawa Y, Nigorikawa K, Takasuga S, Sasaki T, Seya T, Matsumoto M, Hazeki O
PloS one 6 e26836 2011年
UNC93B1 physically associates with human TLR8 and regulates TLR8-mediated signaling.
Itoh H, Tatematsu M, Watanabe A, Iwano K, Funami K, Seya T, Matsumoto M
PloS one 6 e28500 2011年
The ubiquitin ligase Riplet is essential for RIG-I-dependent innate immune responses to RNA virus infection.
Oshiumi H, Miyashita M, Inoue N, Okabe M, Matsumoto M, Seya T
Cell host & microbe 8 496-509 2010年12月
Hepatitis C virus core protein abrogates the DDX3 function that enhances IPS-1-mediated IFN-beta induction.
Oshiumi H, Ikeda M, Matsumoto M, Watanabe A, Takeuchi O, Akira S, Kato N, Shimotohno K, Seya T
PloS one 5 e14258 2010年12月
Innate immunity and vaccine.
Seya T
Vaccine 28 8041-8042 2010年11月
Identification of a polyI:C-inducible membrane protein that participates in dendritic cell-mediated natural killer cell activation.
Ebihara T, Azuma M, Oshiumi H, Kasamatsu J, Iwabuchi K, Matsumoto K, Saito H, Taniguchi T, Matsumoto M, Seya T
The Journal of experimental medicine 207 2675-2687 2010年11月
An embryo-specific expressing TGF-β family protein, growth-differentiation factor 3 (GDF3), augments progression of B16 melanoma.
Ehira N, Oshiumi H, Matsumoto M, Kondo T, Asaka M, Seya T
Journal of experimental & clinical cancer research : CR 29 135 2010年10月
The peptide sequence of diacyl lipopeptides determines dendritic cell TLR2-mediated NK activation.
Azuma M, Sawahata R, Akao Y, Ebihara T, Yamazaki S, Matsumoto M, Hashimoto M, Fukase K, Fujimoto Y, Seya T
PloS one 5 2010年09月
Phylogenetic and expression analysis of lamprey toll-like receptors.
Kasamatsu J, Oshiumi H, Matsumoto M, Kasahara M, Seya T
Developmental and comparative immunology 34 855-865 2010年08月
Adjuvant engineering for cancer immunotherapy: Development of a synthetic TLR2 ligand with increased cell adhesion.
Akazawa T, Inoue N, Shime H, Kodama K, Matsumoto M, Seya T
Cancer science 101 1596-1603 2010年07月
A molecular mechanism for Toll-IL-1 receptor domain-containing adaptor molecule-1-mediated IRF-3 activation.
Tatematsu M, Ishii A, Oshiumi H, Horiuchi M, Inagaki F, Seya T, Matsumoto M
The Journal of biological chemistry 285 20128-20136 2010年06月
[CR1(immune adherence receptor), CR2(EB virus receptor), CR3(Mac-1, CD11b/CD18), CR4(CD11c/CD18)].
Wakasa K, Seya T
Nihon rinsho. Japanese journal of clinical medicine 68 Suppl 6 68-72 2010年06月
[Membrane cofactor protein (MCP, CD46)].
Seya T
Nihon rinsho. Japanese journal of clinical medicine 68 Suppl 6 98-101 2010年06月
DEAD/H BOX 3 (DDX3) helicase binds the RIG-I adaptor IPS-1 to up-regulate IFN-beta-inducing potential.
Oshiumi H, Sakai K, Matsumoto M, Seya T
European journal of immunology 40 940-948 2010年04月
Direct binding of TRAF2 and TRAF6 to TICAM-1/TRIF adaptor participates in activation of the Toll-like receptor 3/4 pathway.
Sasai M, Tatematsu M, Oshiumi H, Funami K, Matsumoto M, Hatakeyama S, Seya T
Molecular immunology 47 1283-1291 2010年03月
Pattern recognition receptors of innate immunity and their application to tumor immunotherapy.
Seya T, Shime H, Ebihara T, Oshiumi H, Matsumoto M
Cancer science 101 313-320 2010年02月
IL-6 and IFN-alpha from dsRNA-stimulated dendritic cells control expansion of regulatory T cells.
Kubota N, Ebihara T, Matsumoto M, Gando S, Seya T
Biochemical and biophysical research communications 391 1421-1426 2010年01月
Dendritic cell-derived TNF-alpha is responsible for development of IL-10-producing CD4+ T cells.
Hirata N, Yanagawa Y, Satoh M, Ogura H, Ebihara T, Noguchi M, Matsumoto M, Togashi H, Seya T, Onoé K, Iwabuchi K
Cellular immunology 261 37-41 2010年
Oligomerized TICAM-1 (TRIF) in the cytoplasm recruits nuclear BS69 to enhance NF-kappaB activation and type I IFN induction.
Takaki H, Oshiumi H, Sasai M, Kawanishi T, Matsumoto M, Seya T
European journal of immunology 39 3469-3476 2009年12月
Lipopeptides from Staphylococcus aureus as Tlr2 Ligands: prediction with mrna expression, chemical synthesis, and immunostimulatory activities.
Fujimoto Y, Hashimoto M, Furuyashiki M, Katsumoto M, Seya T, Suda Y, Fukase K
Chembiochem : a European journal of chemical biology 10 2311-2315 2009年09月
Epstein-Barr virus (EBV)-encoded small RNA is released from EBV-infected cells and activates signaling from Toll-like receptor 3.
Iwakiri D, Zhou L, Samanta M, Matsumoto M, Ebihara T, Seya T, Imai S, Fujieda M, Kawa K, Takada K
The Journal of experimental medicine 206 2091-2099 2009年09月
The extrinsic RNA-sensing pathway for adjuvant immunotherapy of cancer.
Seya T, Matsumoto M
Cancer immunology, immunotherapy : CII 58 1175-1184 2009年08月
Enhancement of antitumor natural killer cell activation by orally administered Spirulina extract in mice.
Akao Y, Ebihara T, Masuda H, Saeki Y, Akazawa T, Hazeki K, Hazeki O, Matsumoto M, Seya T
Cancer science 100 1494-1501 2009年08月
Mitofusin 2 inhibits mitochondrial antiviral signaling.
Yasukawa K, Oshiumi H, Takeda M, Ishihara N, Yanagi Y, Seya T, Kawabata S, Koshiba T
Science signaling 2 ra47 2009年08月
Regulator of complement activation (RCA) gene cluster in Xenopus tropicalis.
Oshiumi H, Suzuki Y, Matsumoto M, Seya T
Immunogenetics 61 371-384 2009年05月
[Role of Toll-like receptors in innate and adaptive immune responses].
Matsumoto M, Seya T
Seikagaku. The Journal of Japanese Biochemical Society 81 156-164 2009年03月
Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection.
Oshiumi H, Matsumoto M, Hatakeyama S, Seya T
The Journal of biological chemistry 284 807-817 2009年01月
Functional evolution of the TICAM-1 pathway for extrinsic RNA sensing.
Seya T, Matsumoto M, Ebihara T, Oshiumi H
Immunological reviews 227 44-53 2009年01月
Obstructing shedding of the immunostimulatory MHC class I chain-related gene B prevents tumor formation.
Wu JD, Atteridge CL, Wang X, Seya T, Plymate SR
Clinical cancer research : an official journal of the American Association for Cancer Research 15 632-640 2009年01月
Innate immune therapy with a Bacillus Calmette-Guérin cell wall skeleton after radical surgery for non-small cell lung cancer: a case-control study.
Kodama K, Higashiyama M, Takami K, Oda K, Okami J, Maeda J, Akazawa T, Matsumoto M, Seya T, Wada M, Toyoshima K
Surgery today 39 194-200 2009年
Pan-vertebrate toll-like receptors during evolution.
Oshiumi H, Matsuo A, Matsumoto M, Seya T
Current genomics 9 488-493 2008年11月
The clathrin-mediated endocytic pathway participates in dsRNA-induced IFN-beta production.
Itoh K, Watanabe A, Funami K, Seya T, Matsumoto M
Journal of immunology (Baltimore, Md. : 1950) 181 5522-5529 2008年10月
Soluble G protein of respiratory syncytial virus inhibits Toll-like receptor 3/4-mediated IFN-beta induction.
Shingai M, Azuma M, Ebihara T, Sasai M, Funami K, Ayata M, Ogura H, Tsutsumi H, Matsumoto M, Seya T
International immunology 20 1169-1180 2008年09月
Teleost TLR22 recognizes RNA duplex to induce IFN and protect cells from birnaviruses.
Matsuo A, Oshiumi H, Tsujita T, Mitani H, Kasai H, Yoshimizu M, Matsumoto M, Seya T
Journal of immunology (Baltimore, Md. : 1950) 181 3474-3485 2008年09月
Modulation of double-stranded RNA recognition by the N-terminal histidine-rich region of the human toll-like receptor 3.
Fukuda K, Watanabe T, Tokisue T, Tsujita T, Nishikawa S, Hasegawa T, Seya T, Matsumoto M
The Journal of biological chemistry 283 22787-22794 2008年08月
Hepatitis C virus-infected hepatocytes extrinsically modulate dendritic cell maturation to activate T cells and natural killer cells.
Ebihara T, Shingai M, Matsumoto M, Wakita T, Seya T
Hepatology (Baltimore, Md.) 48 48-58 2008年07月
Homo-oligomerization is essential for Toll/interleukin-1 receptor domain-containing adaptor molecule-1-mediated NF-kappaB and interferon regulatory factor-3 activation.
Funami K, Sasai M, Oshiumi H, Seya T, Matsumoto M
The Journal of biological chemistry 283 18283-18291 2008年06月
Tumor-secreted lactic acid promotes IL-23/IL-17 proinflammatory pathway.
Shime H, Yabu M, Akazawa T, Kodama K, Matsumoto M, Seya T, Inoue N
Journal of immunology (Baltimore, Md. : 1950) 180 7175-7183 2008年06月
Increased expression of Toll-like receptor 3 in intrahepatic biliary epithelial cells at sites of ductular reaction in diseased livers.
Nakamura M, Funami K, Komori A, Yokoyama T, Aiba Y, Araki A, Takii Y, Ito M, Matsuyama M, Koyabu M, Migita K, Taniguchi K, Fujioka H, Yatsuhashi H, Matsumoto M, Ishibashi H, Seya T
Hepatology international 2 222-230 2008年06月
HCV and innate immunity.
Ebihara T, Matsumoto M, Seya T
Uirusu 58 19-26 2008年06月
Selective synergy in anti-inflammatory cytokine production upon cooperated signaling via TLR4 and TLR2 in murine conventional dendritic cells.
Hirata N, Yanagawa Y, Ebihara T, Seya T, Uematsu S, Akira S, Hayashi F, Iwabuchi K, Onoé K
Molecular immunology 45 2734-2742 2008年05月
TLR3: interferon induction by double-stranded RNA including poly(I:C).
Matsumoto M, Seya T
Advanced drug delivery reviews 60 805-812 2008年04月
Toll-like receptor and pattern sensing for evoking immune response.
Seya T
Advanced drug delivery reviews 60 779-781 2008年04月
The proinflammatory cytokine response to Chlamydia trachomatis elementary bodies in human macrophages is partly mediated by a lipoprotein, the macrophage infectivity potentiator, through TLR2/TLR1/TLR6 and CD14.
Bas S, Neff L, Vuillet M, Spenato U, Seya T, Matsumoto M, Gabay C
Journal of immunology (Baltimore, Md. : 1950) 180 1158-1168 2008年01月
Combinational recognition of bacterial lipoproteins and peptidoglycan by chicken Toll-like receptor 2 subfamily.
Higuchi M, Matsuo A, Shingai M, Shida K, Ishii A, Funami K, Suzuki Y, Oshiumi H, Matsumoto M, Seya T
Developmental and comparative immunology 32 147-155 2008年
Significance of the N-terminal histidine-rich region for the function of the human toll-like receptor 3 ectodomain.
Tokisue T, Watanabe T, Tsujita T, Nishikawa S, Hasegawa T, Seya T, Matsumoto M, Fukuda K
Nucleic acids symposium series (2004)  203-204 2008年
Effect of the alterations in the fusion protein of measles virus isolated from brains of patients with subacute sclerosing panencephalitis on syncytium formation.
Ayata M, Shingai M, Ning X, Matsumoto M, Seya T, Otani S, Seto T, Ohgimoto S, Ogura H
Virus research 130 260-268 2007年12月
Recombinant interleukin-12 and interleukin-18 antitumor therapy in a guinea-pig hepatoma cell implant model.
Shiratori I, Suzuki Y, Oshiumi H, Begum NA, Ebihara T, Matsumoto M, Hazeki K, Kodama K, Kashiwazaki Y, Seya T
Cancer science 98 1936-1942 2007年12月
Differential type I IFN-inducing abilities of wild-type versus vaccine strains of measles virus.
Shingai M, Ebihara T, Begum NA, Kato A, Honma T, Matsumoto K, Saito H, Ogura H, Matsumoto M, Seya T
Journal of immunology (Baltimore, Md. : 1950) 179 6123-6133 2007年11月
Spatiotemporal mobilization of Toll/IL-1 receptor domain-containing adaptor molecule-1 in response to dsRNA.
Funami K, Sasai M, Ohba Y, Oshiumi H, Seya T, Matsumoto M
Journal of immunology (Baltimore, Md. : 1950) 179 6867-6872 2007年11月
Induction of NKG2D ligands on human dendritic cells by TLR ligand stimulation and RNA virus infection.
Ebihara T, Masuda H, Akazawa T, Shingai M, Kikuta H, Ariga T, Matsumoto M, Seya T
International immunology 19 1145-1155 2007年10月
Lipoteichoic acid downregulates FcepsilonRI expression on human mast cells through Toll-like receptor 2.
Yoshioka M, Fukuishi N, Iriguchi S, Ohsaki K, Yamanobe H, Inukai A, Kurihara D, Imajo N, Yasui Y, Matsui N, Tsujita T, Ishii A, Seya T, Takahama M, Akagi M
The Journal of allergy and clinical immunology 120 452-461 2007年08月
C-terminal LRRs of human Toll-like receptor 3 control receptor dimerization and signal transmission.
Takada E, Okahira S, Sasai M, Funami K, Seya T, Matsumoto M
Molecular immunology 44 3633-3640 2007年07月
Tumor immunotherapy using bone marrow-derived dendritic cells overexpressing Toll-like receptor adaptors.
Akazawa T, Shingai M, Sasai M, Ebihara T, Inoue N, Matsumoto M, Seya T
FEBS letters 581 3334-3340 2007年07月
Protein kinase Cdelta binds TIRAP/Mal to participate in TLR signaling.
Kubo-Murai M, Hazeki K, Sukenobu N, Yoshikawa K, Nigorikawa K, Inoue K, Yamamoto T, Matsumoto M, Seya T, Inoue N, Hazeki O
Molecular immunology 44 2257-2264 2007年03月
Inhibition of lipid A-mediated type I interferon induction by bactericidal/permeability-increasing protein (BPI).
Azuma M, Matsuo A, Fujimoto Y, Fukase K, Hazeki K, Hazeki O, Matsumoto M, Seya T
Biochemical and biophysical research communications 354 574-578 2007年03月
Lamprey TLRs with properties distinct from those of the variable lymphocyte receptors.
Ishii A, Matsuo A, Sawa H, Tsujita T, Shida K, Matsumoto M, Seya T
Journal of immunology (Baltimore, Md. : 1950) 178 397-406 2007年01月
TLR3-mediated synthesis and release of eotaxin-1/CCL11 from human bronchial smooth muscle cells stimulated with double-stranded RNA.
Niimi K, Asano K, Shiraishi Y, Nakajima T, Wakaki M, Kagyo J, Takihara T, Suzuki Y, Fukunaga K, Shiomi T, Oguma T, Sayama K, Yamaguchi K, Natori Y, Matsumoto M, Seya T, Yamaya M, Ishizaka A
Journal of immunology (Baltimore, Md. : 1950) 178 489-495 2007年01月
Antitumor NK activation induced by the Toll-like receptor 3-TICAM-1 (TRIF) pathway in myeloid dendritic cells.
Akazawa T, Ebihara T, Okuno M, Okuda Y, Shingai M, Tsujimura K, Takahashi T, Ikawa M, Okabe M, Inoue N, Okamoto-Tanaka M, Ishizaki H, Miyoshi J, Matsumoto M, Seya T
Proceedings of the National Academy of Sciences of the United States of America 104 252-257 2007年01月
N-terminal binding site in the human toll-like receptor 3 ectodomain.
Watanabe T, Tokisue T, Tsujita T, Matsumoto M, Seya T, Nishikawa S, Hasegawa T, Fukuda K
Nucleic acids symposium series (2004)  405-406 2007年
NAK-associated protein 1 participates in both the TLR3 and the cytoplasmic pathways in type I IFN induction.
Sasai M, Shingai M, Funami K, Yoneyama M, Fujita T, Matsumoto M, Seya T
Journal of immunology (Baltimore, Md. : 1950) 177 8676-8683 2006年12月
Intelectin: a novel lipid raft-associated protein in the enterocyte brush border.
Wrackmeyer U, Hansen GH, Seya T, Danielsen EM
Biochemistry 45 9188-9197 2006年08月
The short consensus repeats 1 and 2, not the cytoplasmic domain, of human CD46 are crucial for infection of subgroup B adenovirus serotype 35.
Sakurai F, Murakami S, Kawabata K, Okada N, Yamamoto A, Seya T, Hayakawa T, Mizuguchi H
Journal of controlled release : official journal of the Controlled Release Society 113 271-278 2006年07月
A novel cyclohexene derivative, ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), selectively inhibits toll-like receptor 4-mediated cytokine production through suppression of intracellular signaling.
Ii M, Matsunaga N, Hazeki K, Nakamura K, Takashima K, Seya T, Hazeki O, Kitazaki T, Iizawa Y
Molecular pharmacology 69 1288-1295 2006年04月
Role of Toll-like receptors in adjuvant-augmented immune therapies.
Seya T, Akazawa T, Tsujita T, Matsumoto M
Evidence-based complementary and alternative medicine : eCAM 3 31-8; discussion 133 2006年03月
The kinase complex responsible for IRF-3-mediated IFN-beta production in myeloid dendritic cells (mDC).
Sasai M, Matsumoto M, Seya T
Journal of biochemistry 139 171-175 2006年02月
Physical and functional interactions between STAT3 and Kaposi's sarcoma-associated herpesvirus-encoded LANA.
Muromoto R, Okabe K, Fujimuro M, Sugiyama K, Yokosawa H, Seya T, Matsuda T
FEBS letters 580 93-98 2006年01月
Analysis of the interaction between human TLR3 ectodomain and nucleic acids.
Fukuda K, Tsujita T, Matsumoto M, Seya T, Sakiyama H, Nishikawa F, Nishikawa S, Hasegawa T
Nucleic acids symposium series (2004)  249-250 2006年
Isolation of RNA aptamers against human Toll-like receptor 3 ectodomain.
Watanabe T, Ito K, Matsumoto M, Seya T, Nishikawa S, Hasegawa T, Fukuda K
Nucleic acids symposium series (2004)  251-252 2006年
Differential-expression and tyrosine-phosphorylation profiles of caveolin isoforms in human T cell leukemia cell lines.
Tsuji Y, Hatanaka M, Maeda T, Seya T, Takenaka H, Shimizu A
International journal of molecular medicine 16 889-893 2005年11月
Interferon-beta induction through toll-like receptor 3 depends on double-stranded RNA structure.
Okahira S, Nishikawa F, Nishikawa S, Akazawa T, Seya T, Matsumoto M
DNA and cell biology 24 614-623 2005年10月
Pathways participating in activation of mouse uterine natural killer cells during pregnancy.
Xie X, He H, Colonna M, Seya T, Takai T, Croy BA
Biology of reproduction 73 510-518 2005年09月
Wild-type measles virus infection in human CD46/CD150-transgenic mice: CD11c-positive dendritic cells establish systemic viral infection.
Shingai M, Inoue N, Okuno T, Okabe M, Akazawa T, Miyamoto Y, Ayata M, Honda K, Kurita-Taniguchi M, Matsumoto M, Ogura H, Taniguchi T, Seya T
Journal of immunology (Baltimore, Md. : 1950) 175 3252-3261 2005年09月
Regulator of complement activation (RCA) locus in chicken: identification of chicken RCA gene cluster and functional RCA proteins.
Oshiumi H, Shida K, Goitsuka R, Kimura Y, Katoh J, Ohba S, Tamaki Y, Hattori T, Yamada N, Inoue N, Matsumoto M, Mizuno S, Seya T
Journal of immunology (Baltimore, Md. : 1950) 175 1724-1734 2005年08月
[Immunologic tests: C3 receptor (CR1, 2)].
Okuda N, Seya T
Nihon rinsho. Japanese journal of clinical medicine 63 Suppl 7 67-70 2005年07月
[Immunologic tests: CR3 (Mac-1, CD11b/CD18), CR4 (CD11c/CD18)].
Funami K, Seya T
Nihon rinsho. Japanese journal of clinical medicine 63 Suppl 7 71-73 2005年07月
[Immunologic tests: Membrane cofactor protein (MCP, CD46)].
Shingai M, Seya T
Nihon rinsho. Japanese journal of clinical medicine 63 Suppl 7 95-97 2005年07月
Dendritic cell maturation induced by muramyl dipeptide (MDP) derivatives: monoacylated MDP confers TLR2/TLR4 activation.
Uehori J, Fukase K, Akazawa T, Uematsu S, Akira S, Funami K, Shingai M, Matsumoto M, Azuma I, Toyoshima K, Kusumoto S, Seya T
Journal of immunology (Baltimore, Md. : 1950) 174 7096-7103 2005年06月
Gene-inducing program of human dendritic cells in response to BCG cell-wall skeleton (CWS), which reflects adjuvancy required for tumor immunotherapy.
Ishii K, Kurita-Taniguchi M, Aoki M, Kimura T, Kashiwazaki Y, Matsumoto M, Seya T
Immunology letters 98 280-290 2005年05月
Identification of intelectin overexpression in malignant pleural mesothelioma by serial analysis of gene expression (SAGE).
Wali A, Morin PJ, Hough CD, Lonardo F, Seya T, Carbone M, Pass HI
Lung cancer (Amsterdam, Netherlands) 48 19-29 2005年04月
TICAM-1 and TICAM-2: toll-like receptor adapters that participate in induction of type 1 interferons.
Seya T, Oshiumi H, Sasai M, Akazawa T, Matsumoto M
The international journal of biochemistry & cell biology 37 524-529 2005年03月
Fish soluble Toll-like receptor 5 (TLR5S) is an acute-phase protein with integral flagellin-recognition activity.
Tsukada H, Fukui A, Tsujita T, Matsumoto M, Iida T, Seya T
International journal of molecular medicine 15 519-525 2005年03月
Surface-expressed TLR6 participates in the recognition of diacylated lipopeptide and peptidoglycan in human cells.
Nakao Y, Funami K, Kikkawa S, Taniguchi M, Nishiguchi M, Fukumori Y, Seya T, Matsumoto M
Journal of immunology (Baltimore, Md. : 1950) 174 1566-1573 2005年02月
Cutting Edge: NF-kappaB-activating kinase-associated protein 1 participates in TLR3/Toll-IL-1 homology domain-containing adapter molecule-1-mediated IFN regulatory factor 3 activation.
Sasai M, Oshiumi H, Matsumoto M, Inoue N, Fujita F, Nakanishi M, Seya T
Journal of immunology (Baltimore, Md. : 1950) 174 27-30 2005年01月
Antibodies against human Toll-like receptors (TLRs): TLR distribution and localization in human dendritic cells.
Seya T, Funami K, Taniguchi M, Matsumoto M
Journal of endotoxin research 11 369-374 2005年
Sensing bacterial flagellin by membrane and soluble orthologs of Toll-like receptor 5 in rainbow trout (Onchorhynchus mikiss).
Tsujita T, Tsukada H, Nakao M, Oshiumi H, Matsumoto M, Seya T
The Journal of biological chemistry 279 48588-48597 2004年11月
The cytoplasmic 'linker region' in Toll-like receptor 3 controls receptor localization and signaling.
Funami K, Matsumoto M, Oshiumi H, Akazawa T, Yamamoto A, Seya T
International immunology 16 1143-1154 2004年08月
A short consensus repeat-containing complement regulatory protein of lamprey that participates in cleavage of lamprey complement 3.
Kimura Y, Inoue N, Fukui A, Oshiumi H, Matsumoto M, Nonaka M, Kuratani S, Fujita T, Nonaka M, Seya T
Journal of immunology (Baltimore, Md. : 1950) 173 1118-1128 2004年07月
[Toll-like receptors that sense viral infection].
Seya T, Shingai M, Matsumoto M
Uirusu 54 1-8 2004年06月
Mycobacterium bovis BCG cell wall-specific differentially expressed genes identified by differential display and cDNA subtraction in human macrophages.
Begum NA, Ishii K, Kurita-Taniguchi M, Tanabe M, Kobayashi M, Moriwaki Y, Matsumoto M, Fukumori Y, Azuma I, Toyoshima K, Seya T
Infection and immunity 72 937-948 2004年02月
Adjuvant-mediated tumor regression and tumor-specific cytotoxic response are impaired in MyD88-deficient mice.
Akazawa T, Masuda H, Saeki Y, Matsumoto M, Takeda K, Tsujimura K, Kuzushima K, Takahashi T, Azuma I, Akira S, Toyoshima K, Seya T
Cancer research 64 757-764 2004年01月
Toll-like receptor 3: a link between toll-like receptor, interferon and viruses.
Matsumoto M, Funami K, Oshiumi H, Seya T
Microbiology and immunology 48 147-154 2004年
Infection of different cell lines of neural origin with subacute sclerosing panencephalitis (SSPE) virus.
Ishida H, Ayata M, Shingai M, Matsunaga I, Seto Y, Katayama Y, Iritani N, Seya T, Yanagi Y, Matsuoka O, Yamano T, Ogura H
Microbiology and immunology 48 277-287 2004年
TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta.
Oshiumi H, Sasai M, Shida K, Fujita T, Matsumoto M, Seya T
The Journal of biological chemistry 278 49751-49762 2003年12月
Mechanism of up-regulation of human Toll-like receptor 3 secondary to infection of measles virus-attenuated strains.
Tanabe M, Kurita-Taniguchi M, Takeuchi K, Takeda M, Ayata M, Ogura H, Matsumoto M, Seya T
Biochemical and biophysical research communications 311 39-48 2003年11月
Role of toll-like receptors and their adaptors in adjuvant immunotherapy for cancer.
Seya T, Akazawa T, Uehori J, Matsumoto M, Azuma I, Toyoshima K
Anticancer research 23 4369-4376 2003年11月
Subcellular localization of Toll-like receptor 3 in human dendritic cells.
Matsumoto M, Funami K, Tanabe M, Oshiumi H, Shingai M, Seto Y, Yamamoto A, Seya T
Journal of immunology (Baltimore, Md. : 1950) 171 3154-3162 2003年09月
Selective contribution of IFN-alpha/beta signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection.
Honda K, Sakaguchi S, Nakajima C, Watanabe A, Yanai H, Matsumoto M, Ohteki T, Kaisho T, Takaoka A, Akira S, Seya T, Taniguchi T
Proceedings of the National Academy of Sciences of the United States of America 100 10872-10877 2003年09月
Receptor use by vesicular stomatitis virus pseudotypes with glycoproteins of defective variants of measles virus isolated from brains of patients with subacute sclerosing panencephalitis.
Shingai M, Ayata M, Ishida H, Matsunaga I, Katayama Y, Seya T, Tatsuo H, Yanagi Y, Ogura H
The Journal of general virology 84 2133-2143 2003年08月
Simultaneous blocking of human Toll-like receptors 2 and 4 suppresses myeloid dendritic cell activation induced by Mycobacterium bovis bacillus Calmette-Guérin peptidoglycan.
Uehori J, Matsumoto M, Tsuji S, Akazawa T, Takeuchi O, Akira S, Kawata T, Azuma I, Toyoshima K, Seya T
Infection and immunity 71 4238-4249 2003年08月
Down-regulation of Toll-like receptor expression in monocyte-derived Langerhans cell-like cells: implications of low-responsiveness to bacterial components in the epidermal Langerhans cells.
Takeuchi J, Watari E, Shinya E, Norose Y, Matsumoto M, Seya T, Sugita M, Kawana S, Takahashi H
Biochemical and biophysical research communications 306 674-679 2003年07月
Disruption of mouse CD46 causes an accelerated spontaneous acrosome reaction in sperm.
Inoue N, Ikawa M, Nakanishi T, Matsumoto M, Nomura M, Seya T, Okabe M
Molecular and cellular biology 23 2614-2622 2003年04月
Toll-like receptor-mediated tyrosine phosphorylation of paxillin via MyD88-dependent and -independent pathways.
Hazeki K, Masuda N, Funami K, Sukenobu N, Matsumoto M, Akira S, Takeda K, Seya T, Hazeki O
European journal of immunology 33 740-747 2003年03月
TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction.
Oshiumi H, Matsumoto M, Funami K, Akazawa T, Seya T
Nature immunology 4 161-167 2003年02月
Prediction of the prototype of the human Toll-like receptor gene family from the pufferfish, Fugu rubripes, genome.
Oshiumi H, Tsujita T, Shida K, Matsumoto M, Ikeo K, Seya T
Immunogenetics 54 791-800 2003年02月
Mycobacterium bovis BCG cell wall and lipopolysaccharide induce a novel gene, BIGM103, encoding a 7-TM protein: identification of a new protein family having Zn-transporter and Zn-metalloprotease signatures.
Begum NA, Kobayashi M, Moriwaki Y, Matsumoto M, Toyoshima K, Seya T
Genomics 80 630-645 2002年12月
Mapping of the sites responsible for factor I-cofactor activity for cleavage of C3b and C4b on human C4b-binding protein (C4bp) by deletion mutagenesis.
Fukui A, Yuasa-Nakagawa T, Murakami Y, Funami K, Kishi N, Matsuda T, Fujita T, Seya T, Nagasawa S
Journal of biochemistry 132 719-728 2002年11月
Mechanism of host cell protection from complement in murine cytomegalovirus (CMV) infection: identification of a CMV-responsive element in the CD46 promoter region.
Nomura M, Kurita-Taniguchi M, Kondo K, Inoue N, Matsumoto M, Yamanishi K, Okabe M, Seya T
European journal of immunology 32 2954-2964 2002年10月
A lipoprotein family from Mycoplasma fermentans confers host immune activation through Toll-like receptor 2.
Seya T, Matsumoto M
The international journal of biochemistry & cell biology 34 901-906 2002年08月
[RNA interference for mammalian cells].
Oshiumi H, Begum NA, Matsumoto M, Seya T
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 120 91-95 2002年08月
Human herpesvirus 6 variant A but not variant B induces fusion from without in a variety of human cells through a human herpesvirus 6 entry receptor, CD46.
Mori Y, Seya T, Huang HL, Akkapaiboon P, Dhepakson P, Yamanishi K
Journal of virology 76 6750-6761 2002年07月
Ligation of human CD46 with purified complement C3b or F(ab')(2) of monoclonal antibodies enhances isoform-specific interferon gamma-dependent nitric oxide production in macrophages.
Hirano A, Kurita-Taniguchi M, Katayama Y, Matsumoto M, Wong TC, Seya T
Journal of biochemistry 132 83-91 2002年07月
Structural-functional relationship of pathogen-associated molecular patterns: lessons from BCG cell wall skeleton and mycoplasma lipoprotein M161Ag.
Seya T, Matsumoto M, Tsuji S, Begum NA, Azuma I, Toyoshima K
Microbes and infection / Institut Pasteur 4 955-961 2002年07月
Susceptibility of human dendritic cells (DCs) to measles virus (MV) depends on their activation stages in conjunction with the level of CDw150: role of Toll stimulators in DC maturation and MV amplification.
Murabayashi N, Kurita-Taniguchi M, Ayata M, Matsumoto M, Ogura H, Seya T
Microbes and infection / Institut Pasteur 4 785-794 2002年07月
Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling.
Matsumoto M, Kikkawa S, Kohase M, Miyake K, Seya T
Biochemical and biophysical research communications 293 1364-1369 2002年05月
Transgenic pigs expressing human decay-accelerating factor regulated by porcine MCP gene promoter.
Murakami H, Nagashima H, Takahagi Y, Miyagawa S, Fujimura T, Toyomura K, Nakai R, Yamada M, Kurihara T, Shigehisa T, Okabe M, Seya T, Shirakura R, Kinoshita T
Molecular reproduction and development 61 302-311 2002年03月
Activation of the human innate immune system by Spirulina: augmentation of interferon production and NK cytotoxicity by oral administration of hot water extract of Spirulina platensis.
Hirahashi T, Matsumoto M, Hazeki K, Saeki Y, Ui M, Seya T
International immunopharmacology 2 423-434 2002年03月
Molecular assembly of CD46 with CD9, alpha3-beta1 integrin and protein tyrosine phosphatase SHP-1 in human macrophages through differentiation by GM-CSF.
Kurita-Taniguchi M, Hazeki K, Murabayashi N, Fukui A, Tsuji S, Matsumoto M, Toyoshima K, Seya T
Molecular immunology 38 689-700 2002年02月
High levels of RAE-1 isoforms on mouse tumor cell lines assessed by anti-"pan" RAE-1 antibody confer tumor susceptibility to NK cells.
Masuda H, Saeki Y, Nomura M, Shida K, Matsumoto M, Ui M, Lanier LL, Seya T
Biochemical and biophysical research communications 290 140-145 2002年01月

作品等

21世紀COEプログラム<バイオとナノを融合する新生命科学拠点>シンポジウム「創薬を目指したケミカルバイオロジー研究の最前線」(札幌):合成ワクチンアジュバントによる樹状細胞の機能分化(特別講演)
2005年 
作品等を全て表示する
作品等閉じる
21世紀COEプログラム<バイオとナノを融合する新生命科学拠点>シンポジウム「創薬を目指したケミカルバイオロジー研究の最前線」(札幌):合成ワクチンアジュバントによる樹状細胞の機能分化(特別講演)
2005年 

特許

抗TLR6抗体およびその利用
免疫応答を惹起するための新規アジュバントおよびその利用
diRNAを有効成分とする免疫治療用薬剤
I型インターフェロンの発現調節剤
特許を全て表示する
特許閉じる
抗TLR6抗体およびその利用
免疫応答を惹起するための新規アジュバントおよびその利用
diRNAを有効成分とする免疫治療用薬剤
I型インターフェロンの発現調節剤

受賞

2009年
日本医師会医学研究助成費 
2006年
武田科学振興財団研究助成金(一般研究奨励) 
2005年
三菱財団研究奨励賞 
2003年
高松宮妃がん研究奨励賞 
受賞を全て表示する
受賞閉じる
2009年
日本医師会医学研究助成費 
2006年
武田科学振興財団研究助成金(一般研究奨励) 
2005年
三菱財団研究奨励賞 
2003年
高松宮妃がん研究奨励賞 

競争的資金等の研究課題

自然免疫
:JST戦略的創造研究推進制度(研究チーム型) (戦略的基礎研究推進事業:CREST)
研究期間 : 1979年
競争的資金等の研究課題を全て表示する
競争的資金等の研究課題閉じる
自然免疫
:JST戦略的創造研究推進制度(研究チーム型) (戦略的基礎研究推進事業:CREST)
研究期間 : 1979年

社会貢献

委員歴

2008年
日本免疫学会 広報委員
委員歴を全て表示する
委員歴閉じる
2008年
日本免疫学会 広報委員

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