瀬谷 司セヤ ツカサresearchmap個人ページ

更新日 : 2017/11/17

基本情報

プロフィール

所属部署名
医学研究院  
職名特任教授 
学位
医学博士(北海道大学)
薬学博士(北海道大学)
メールアドレス
ホームページURLhttp://vaccine_immunology.hokkaido.university
科研費研究者番号

研究キーワード

免疫学, ウイルス学, がん免疫

研究分野

基礎医学 / 免疫学
基礎医学 / ウイルス学
内科系臨床医学 / 膠原病・アレルギー内科学
研究分野を全て表示する
研究分野閉じる
基礎医学 / 免疫学
基礎医学 / ウイルス学
内科系臨床医学 / 膠原病・アレルギー内科学

職歴

2017年
-
現在
北海道大学大学院医学研究院ワクチン免疫学分野
2009年
-
2016年
- 北海道大学大学院医学研究科免疫学分野 教授
2006年
-
2009年
 北海道大学先端生命科学研究院 教授
2004年
-
2007年
 大阪府立成人病センター研究所 研究員
2005年
-
2007年
 東京大学医学研究科非常勤講師(併任) 講師
2005年
-
2006年
 京都大学ウイルス研究所客員教授 教授
1998年
-
2004年
 奈良先端大学院大学客員教授 教授
2001年
-
2004年
 大阪府立成人病センター研究所 所長
2003年
-
2004年
 大阪大学医学研究科客員教授 教授
1998年
-
2001年
 大阪府立成人病センター研究所 免疫部門 部長
職歴を全て表示する
職歴閉じる
2017年
-
現在
北海道大学大学院医学研究院ワクチン免疫学分野
2009年
-
2016年
- 北海道大学大学院医学研究科免疫学分野 教授
2006年
-
2009年
 北海道大学先端生命科学研究院 教授
2004年
-
2007年
 大阪府立成人病センター研究所 研究員
2005年
-
2007年
 東京大学医学研究科非常勤講師(併任) 講師
2005年
-
2006年
 京都大学ウイルス研究所客員教授 教授
1998年
-
2004年
 奈良先端大学院大学客員教授 教授
2001年
-
2004年
 大阪府立成人病センター研究所 所長
2003年
-
2004年
 大阪大学医学研究科客員教授 教授
1998年
-
2001年
 大阪府立成人病センター研究所 免疫部門 部長
1987年
-
1998年
 大阪府立成人病センター研究所免疫部門 室長
1984年
-
1987年
 米国ワシントン大学微生物・免疫学講座 研究員
1979年
-
1984年
 北海道大学薬学部 衛生化学部門 研究生
1976年
-
1979年
 北海道大学医学部附属病院1内科 医員
2004年
- 北海道大学大学院医学研究科免疫学分野 教授

学歴

北海道大学 薬学部 学位取得終了(S59)
北海道大学 医学部 卒(S51)
学歴を全て表示する
学歴閉じる
北海道大学 薬学部 学位取得終了(S59)
北海道大学 医学部 卒(S51)

所属学協会

日本分子生物学会
日本免疫学会
日本エンドトキシン研究会
日本生化学会
日本がん免疫学会
日本ウィルス学会
日本癌学会
日本インターフェロン・サイトカイン学会
日本生体防御学会
バイオ治療法研究会
所属学協会を全て表示する
所属学協会閉じる
日本分子生物学会
日本免疫学会
日本エンドトキシン研究会
日本生化学会
日本がん免疫学会
日本ウィルス学会
日本癌学会
日本インターフェロン・サイトカイン学会
日本生体防御学会
バイオ治療法研究会

研究活動

論文

The TLR3/TICAM-1 signal constitutively controls spontaneous polyposis through suppression of c-Myc in Apc Min/+ mice.
Ono J, Shime H, Takaki H, Takashima K, Funami K, Yoshida S, Takeda Y, Matsumoto M, Kasahara M, Seya T
Journal of biomedical science 24(1) 79 2017年10月
Zyxin stabilizes RIG-I and MAVS interactions and promotes type I interferon response.
Kouwaki T, Okamoto M, Tsukamoto H, Fukushima Y, Matsumoto M, Seya T, Oshiumi H
Scientific reports 7(1) 11905 2017年09月
Functional interfaces between TICAM-2/TRAM and TICAM-1/TRIF in TLR4 signaling.
Funami K, Matsumoto M, Oshiumi H, Inagaki F, Seya T
Biochemical Society transactions 45(4) 929-935 2017年08月
Recognition of Viral RNA by Pattern Recognition Receptors in the Induction of Innate Immunity and Excessive Inflammation During Respiratory Viral Infections.
Okamoto M, Tsukamoto H, Kouwaki T, Seya T, Oshiumi H
Viral immunology 30(6) 408-420 2017年07月
A TLR3-Specific Adjuvant Relieves Innate Resistance to PD-L1 Blockade without Cytokine Toxicity in Tumor Vaccine Immunotherapy.
Takeda Y, Kataoka K, Yamagishi J, Ogawa S, Seya T, Matsumoto M
Cell reports 19(9) 1874-1887 2017年05月
Development of mouse models for analysis of human virus infections.
Takaki H, Oshiumi H, Shingai M, Matsumoto M, Seya T
Microbiology and immunology 61(3-4) 107-113 2017年04月
Double-stranded RNA promotes CTL-independent tumor cytolysis mediated by CD11b+Ly6G+ intratumor myeloid cells through the TICAM-1 signaling pathway.
Shime H, Matsumoto M, Seya T
Cell death and differentiation 24(3) 385-396 2017年03月
The Anti-Oxidant Ergothioneine Augments the Immunomodulatory Function of TLR Agonists by Direct Action on Macrophages.
Yoshida S, Shime H, Funami K, Takaki H, Matsumoto M, Kasahara M, Seya T
PloS one 12(1) e0169360 2017年01月
HTLV-1 Tax Induces Formation of the Active Macromolecular IKK Complex by Generating Lys63- and Met1-Linked Hybrid Polyubiquitin Chains.
Shibata Y, Tokunaga F, Goto E, Komatsu G, Gohda J, Saeki Y, Tanaka K, Takahashi H, Sawasaki T, Inoue S, Oshiumi H, Seya T, Nakano H, Tanaka Y, Iwai K, Inoue JI
PLoS pathogens 13(1) e1006162 2017年01月
Measles virus hemagglutinin triggers intracellular signaling in CD150-expressing dendritic cells and inhibits immune response.
Romanets-Korbut O, Kovalevska LM, Seya T, Sidorenko SP, Horvat B
Cellular & molecular immunology 13(6) 828-838 2016年11月
論文を全て表示する
論文閉じる
The TLR3/TICAM-1 signal constitutively controls spontaneous polyposis through suppression of c-Myc in Apc Min/+ mice.
Ono J, Shime H, Takaki H, Takashima K, Funami K, Yoshida S, Takeda Y, Matsumoto M, Kasahara M, Seya T
Journal of biomedical science 24(1) 79 2017年10月
Zyxin stabilizes RIG-I and MAVS interactions and promotes type I interferon response.
Kouwaki T, Okamoto M, Tsukamoto H, Fukushima Y, Matsumoto M, Seya T, Oshiumi H
Scientific reports 7(1) 11905 2017年09月
Functional interfaces between TICAM-2/TRAM and TICAM-1/TRIF in TLR4 signaling.
Funami K, Matsumoto M, Oshiumi H, Inagaki F, Seya T
Biochemical Society transactions 45(4) 929-935 2017年08月
Recognition of Viral RNA by Pattern Recognition Receptors in the Induction of Innate Immunity and Excessive Inflammation During Respiratory Viral Infections.
Okamoto M, Tsukamoto H, Kouwaki T, Seya T, Oshiumi H
Viral immunology 30(6) 408-420 2017年07月
A TLR3-Specific Adjuvant Relieves Innate Resistance to PD-L1 Blockade without Cytokine Toxicity in Tumor Vaccine Immunotherapy.
Takeda Y, Kataoka K, Yamagishi J, Ogawa S, Seya T, Matsumoto M
Cell reports 19(9) 1874-1887 2017年05月
Development of mouse models for analysis of human virus infections.
Takaki H, Oshiumi H, Shingai M, Matsumoto M, Seya T
Microbiology and immunology 61(3-4) 107-113 2017年04月
Double-stranded RNA promotes CTL-independent tumor cytolysis mediated by CD11b+Ly6G+ intratumor myeloid cells through the TICAM-1 signaling pathway.
Shime H, Matsumoto M, Seya T
Cell death and differentiation 24(3) 385-396 2017年03月
The Anti-Oxidant Ergothioneine Augments the Immunomodulatory Function of TLR Agonists by Direct Action on Macrophages.
Yoshida S, Shime H, Funami K, Takaki H, Matsumoto M, Kasahara M, Seya T
PloS one 12(1) e0169360 2017年01月
HTLV-1 Tax Induces Formation of the Active Macromolecular IKK Complex by Generating Lys63- and Met1-Linked Hybrid Polyubiquitin Chains.
Shibata Y, Tokunaga F, Goto E, Komatsu G, Gohda J, Saeki Y, Tanaka K, Takahashi H, Sawasaki T, Inoue S, Oshiumi H, Seya T, Nakano H, Tanaka Y, Iwai K, Inoue JI
PLoS pathogens 13(1) e1006162 2017年01月
Measles virus hemagglutinin triggers intracellular signaling in CD150-expressing dendritic cells and inhibits immune response.
Romanets-Korbut O, Kovalevska LM, Seya T, Sidorenko SP, Horvat B
Cellular & molecular immunology 13(6) 828-838 2016年11月
Interferon-stimulated gene of 20 kDa protein (ISG20) degrades RNA of hepatitis B virus to impede the replication of HBV in vitro and in vivo.
Leong CR, Funami K, Oshiumi H, Mengao D, Takaki H, Matsumoto M, Aly HH, Watashi K, Chayama K, Seya T
Oncotarget 7(42) 68179-68193 2016年10月
STING in tumor and host cells cooperatively work for NK cell-mediated tumor growth retardation.
Takashima K, Takeda Y, Oshiumi H, Shime H, Okabe M, Ikawa M, Matsumoto M, Seya T
Biochemical and biophysical research communications 478(4) 1764-1771 2016年09月
Tumoricidal efficacy coincides with CD11c up-regulation in antigen-specific CD8(+) T cells during vaccine immunotherapy.
Takeda Y, Azuma M, Matsumoto M, Seya T
Journal of experimental & clinical cancer research : CR 35(1) 143 2016年09月
The dataset of proteins specifically interacted with activated TICAM-1.
Funami K, Matsumoto M, Oshiumi H, Obuse C, Seya T
Data in brief 8 697-699 2016年09月
Extracellular Vesicles Including Exosomes Regulate Innate Immune Responses to Hepatitis B Virus Infection.
Kouwaki T, Fukushima Y, Daito T, Sanada T, Yamamoto N, Mifsud EJ, Leong CR, Tsukiyama-Kohara K, Kohara M, Matsumoto M, Seya T, Oshiumi H
Frontiers in immunology 7 335 2016年08月
Biphasic function of TLR3 adjuvant on tumor and spleen dendritic cells promotes tumor T cell infiltration and regression in a vaccine therapy.
Azuma M, Takeda Y, Nakajima H, Sugiyama H, Ebihara T, Oshiumi H, Matsumoto M, Seya T
Oncoimmunology 5(8) e1188244 2016年08月
Cytokine responses to eye spray adjuvants for enhancing vaccine-induced immunity in chickens.
Takaki H, Sato H, Kurata R, Hikono H, Hiono T, Kida H, Matsumoto M, Saito T, Seya T
Microbiology and immunology 60(7) 511-515 2016年07月
Aberrant PD-L1 expression through 3'-UTR disruption in multiple cancers.
Kataoka K, Shiraishi Y, Takeda Y, Sakata S, Matsumoto M, Nagano S, Maeda T, Nagata Y, Kitanaka A, Mizuno S, Tanaka H, Chiba K, Ito S, Watatani Y, Kakiuchi N, Suzuki H, Yoshizato T, Yoshida K, Sanada M, Itonaga H, Imaizumi Y, Totoki Y, Munakata W, Nakamura H, Hama N, Shide K, Kubuki Y, Hidaka T, Kameda T, Masuda K, Minato N, Kashiwase K, Izutsu K, Takaori-Kondo A, Miyazaki Y, Takahashi S, Shibata T, Kawamoto H, Akatsuka Y, Shimoda K, Takeuchi K, Seya T, Miyano S, Ogawa S
Nature 534(7607) 402-406 2016年06月
Accessory Factors of Cytoplasmic Viral RNA Sensors Required for Antiviral Innate Immune Response.
Oshiumi H, Kouwaki T, Seya T
Frontiers in immunology 7 200 2016年05月
Double-stranded RNA analog and type I interferon regulate expression of Trem paired receptors in murine myeloid cells.
Kasamatsu J, Deng M, Azuma M, Funami K, Shime H, Oshiumi H, Matsumoto M, Kasahara M, Seya T
BMC immunology 17(1) 9 2016年05月
Raftlin Controls Lipopolysaccharide-Induced TLR4 Internalization and TICAM-1 Signaling in a Cell Type-Specific Manner.
Tatematsu M, Yoshida R, Morioka Y, Ishii N, Funami K, Watanabe A, Saeki K, Seya T, Matsumoto M
Journal of immunology (Baltimore, Md. : 1950) 196(9) 3865-3876 2016年05月
14-3-3-zeta participates in TLR3-mediated TICAM-1 signal-platform formation.
Funami K, Matsumoto M, Obuse C, Seya T
Molecular immunology 73 60-68 2016年05月
Live imaging of transforming growth factor-β activated kinase 1 activation in Lewis lung carcinoma 3LL cells implanted into syngeneic mice and treated with polyinosinic:polycytidylic acid.
Takaoka S, Kamioka Y, Takakura K, Baba A, Shime H, Seya T, Matsuda M
Cancer science 107(5) 644-652 2016年05月
Tumor vaccines with dsRNA adjuvant ARNAX induces antigen-specific tumor shrinkage without cytokinemia.
Seya T, Takeda Y, Matsumoto M
Oncoimmunology 5(2) e1043506 2016年02月
[Nucleic acid pattern recognition for innate sensing of hepatitis B virus (HBV)].
Seya T, Funami K, Matsumoto M, Oshiumi H
Nihon rinsho. Japanese journal of clinical medicine 73 Suppl 9 392-396 2015年12月
Adjuvant for vaccine immunotherapy of cancer--focusing on Toll-like receptor 2 and 3 agonists for safely enhancing antitumor immunity.
Seya T, Shime H, Takeda Y, Tatematsu M, Takashima K, Matsumoto M
Cancer science 106(12) 1659-1668 2015年12月
LRRC59 Regulates Trafficking of Nucleic Acid-Sensing TLRs from the Endoplasmic Reticulum via Association with UNC93B1.
Tatematsu M, Funami K, Ishii N, Seya T, Obuse C, Matsumoto M
Journal of immunology (Baltimore, Md. : 1950) 195(10) 4933-4942 2015年11月
Identification of a Regulatory Acidic Motif as the Determinant of Membrane Localization of TICAM-2.
Funami K, Matsumoto M, Enokizono Y, Ishii N, Tatematsu M, Oshiumi H, Inagaki F, Seya T
Journal of immunology (Baltimore, Md. : 1950) 195(9) 4456-4465 2015年11月
Development of a non-inflammatory adjuvant for vaccine immunotherapy against cancer
Matsumoto Misako, Seya Tsukasa
ANNALS OF ONCOLOGY 26 30 2015年11月
RIOK3 keeps MDA5 inactive.
Takashima K, Oshiumi H, Seya T
Oncotarget 6(31) 30423-30424 2015年10月
Interferon (IFN) and Cellular Immune Response Evoked in RNA-Pattern Sensing During Infection with Hepatitis C Virus (HCV).
Nakai M, Oshiumi H, Funami K, Okamoto M, Matsumoto M, Seya T, Sakamoto N
Sensors (Basel, Switzerland) 15(10) 27160-27173 2015年10月
Evolution of the DEAD box helicase family in chicken: chickens have no DHX9 ortholog.
Sato H, Oshiumi H, Takaki H, Hikono H, Seya T
Microbiology and immunology 59(10) 633-640 2015年10月
Functional Alteration of Tumor-infiltrating Myeloid Cells in RNA Adjuvant Therapy.
Seya T, Shime H, Matsumoto M
Anticancer research 35(8) 4385-4392 2015年08月
PolyI:C-Induced, TLR3/RIP3-Dependent Necroptosis Backs Up Immune Effector-Mediated Tumor Elimination In Vivo.
Takemura R, Takaki H, Okada S, Shime H, Akazawa T, Oshiumi H, Matsumoto M, Teshima T, Seya T
Cancer immunology research 3(8) 902-914 2015年08月
Identification of a polyI:C-inducible membrane protein that participates in dendritic cell-mediated natural killer cell activation.
Ebihara T, Azuma M, Oshiumi H, Kasamatsu J, Iwabuchi K, Matsumoto K, Saito H, Taniguchi T, Matsumoto M, Seya T
The Journal of experimental medicine 212(8) 1337 2015年07月
DDX60 Is Involved in RIG-I-Dependent and Independent Antiviral Responses, and Its Function Is Attenuated by Virus-Induced EGFR Activation.
Oshiumi H, Miyashita M, Okamoto M, Morioka Y, Okabe M, Matsumoto M, Seya T
Cell reports 11(8) 1193-1207 2015年05月
RIOK3-mediated phosphorylation of MDA5 interferes with its assembly and attenuates the innate immune response.
Takashima K, Oshiumi H, Takaki H, Matsumoto M, Seya T
Cell reports 11(2) 192-200 2015年04月
Pam2 lipopeptides systemically increase myeloid-derived suppressor cells through TLR2 signaling.
Maruyama A, Shime H, Takeda Y, Azuma M, Matsumoto M, Seya T
Biochemical and biophysical research communications 457(3) 445-450 2015年02月
[Chronic hepatitis C virus infection attenuates host antiviral innate immune response].
Oshiumi H, Matsumoto M, Seya T
Nihon rinsho. Japanese journal of clinical medicine 73(2) 234-238 2015年02月
Defined TLR3-specific adjuvant that induces NK and CTL activation without significant cytokine production in vivo.
Matsumoto M, Tatematsu M, Nishikawa F, Azuma M, Ishii N, Morii-Sakai A, Shime H, Seya T
Nature communications 6 6280 2015年02月
PolyI:C and mouse survivin artificially embedding human 2B peptide induce a CD4+ T cell response to autologous survivin in HLA-A*2402 transgenic mice.
Kasamatsu J, Takahashi S, Azuma M, Matsumoto M, Morii-Sakai A, Imamura M, Teshima T, Takahashi A, Hirohashi Y, Torigoe T, Sato N, Seya T
Immunobiology 220(1) 74-82 2015年01月
Interferon (IFN) and Cellular Immune Response Evoked in RNA-Pattern Sensing During Infection with Hepatitis C Virus (HCV).
Masato Nakai,Hiroyuki Oshiumi,Kenji Funami,Masaaki Okamoto,Misako Matsumoto,Tsukasa Seya,Naoya Sakamoto
Sensors 15(10) 27160-27173 2015年
A MAVS/TICAM-1-independent interferon-inducing pathway contributes to regulation of hepatitis B virus replication in the mouse hydrodynamic injection model.
Leong CR, Oshiumi H, Okamoto M, Azuma M, Takaki H, Matsumoto M, Chayama K, Seya T
Journal of innate immunity 7(1) 47-58 2015年
INAM plays a critical role in IFN-γ production by NK cells interacting with polyinosinic-polycytidylic acid-stimulated accessory cells.
Kasamatsu J, Azuma M, Oshiumi H, Morioka Y, Okabe M, Ebihara T, Matsumoto M, Seya T
Journal of immunology (Baltimore, Md. : 1950) 193(10) 5199-5207 2014年11月
Endosomal localization of TLR8 confers distinctive proteolytic processing on human myeloid cells.
Ishii N, Funami K, Tatematsu M, Seya T, Matsumoto M
Journal of immunology (Baltimore, Md. : 1950) 193(10) 5118-5128 2014年11月
The J6JFH1 Strain of Hepatitis C Virus Infects Human B-Cells with Low Replication Efficacy.
Nakai M, Seya T, Matsumoto M, Shimotohno K, Sakamoto N, Aly HH
Viral immunology 27(6) 285-294 2014年08月
[RNA structure recognized by Toll-like receptor 3 in innate immunity].
Tatematsu M, Seya T, Matsumoto M
Seikagaku. The Journal of Japanese Biochemical Society 86(4) 523-527 2014年08月
Measles Virus Takes a Two-Pronged Attack on PP1.
Seya T
Cell host & microbe 16(1) 1-2 2014年07月
Dendritic cell subsets involved in type I IFN induction in mouse measles virus infection models.
Takaki H, Oshiumi H, Matsumoto M, Seya T
The international journal of biochemistry & cell biology 53C 329-333 2014年06月
IPS-1 is essential for type III IFN production by hepatocytes and dendritic cells in response to hepatitis C virus infection.
Okamoto M, Oshiumi H, Azuma M, Kato N, Matsumoto M, Seya T
Journal of immunology (Baltimore, Md. : 1950) 192(6) 2770-2777 2014年03月
Beyond dsRNA: Toll-like receptor 3 signalling in RNA-induced immune responses.
Tatematsu M, Seya T, Matsumoto M
The Biochemical journal 458(2) 195-201 2014年03月
The N-terminal domain of TIR domain-containing adaptor molecule-1, TICAM-1.
Kumeta H, Sakakibara H, Enokizono Y, Ogura K, Horiuchi M, Matsumoto M, Seya T, Inagaki F
Journal of biomolecular NMR 58(3) 227-230 2014年03月
an embryo-specific expressing TGF-beta family protein, growth-differentiation factor 3 (GDF3), augments progression of B16 melanoma (vol 33, pg 22, 2014)
Ehira Nobuyuki, Oshiumi Hiroyuki, Matsumoto Misako, Kondo Takeshi, Asaka Masahiro, Seya Tsukasa
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 33 2014年02月
MAVS-dependent IRF3/7 bypass of interferon β-induction restricts the response to measles infection in CD150Tg mouse bone marrow-derived dendritic cells.
Takaki H, Honda K, Atarashi K, Kobayashi F, Ebihara T, Oshiumi H, Matsumoto M, Shingai M, Seya T
Molecular immunology 57(2) 100-110 2014年02月
Characterization of a lymphotropic HCV-J6JFH1 replication in human primary B cells
Nakai Masato, Seya Tsukasa, Matsumoto Misako, Aly Hussein H., Itoh Jun, Tsunematsu Seiji, Sato Fumiyuki, Tsukuda Yoko, Terashita Katsumi, Sho Takuya, Suda Goki, Natsuizaka Mitsuteru, Ogawa Koji, Sakamoto Naoya
HEPATOLOGY 60 1083A-1084A 2014年
Assessment of the Toll-like receptor 3 pathway in endosomal signaling.
Matsumoto M, Funami K, Tatematsu M, Azuma M, Seya T
Methods in enzymology 535 149-165 2014年
Myeloid-derived suppressor cells confer tumor-suppressive functions on natural killer cells via polyinosinic:polycytidylic acid treatment in mouse tumor models.
Shime H, Kojima A, Maruyama A, Saito Y, Oshiumi H, Matsumoto M, Seya T
Journal of innate immunity 6(3) 293-305 2014年
Cell type-specific subcellular localization of phospho-TBK1 in response to cytoplasmic viral DNA.
Suzuki T, Oshiumi H, Miyashita M, Aly HH, Matsumoto M, Seya T
PloS one 8(12) e83639 2013年12月
Structures and interface mapping of the TIR domain-containing adaptor molecules involved in interferon signaling.
Enokizono Y, Kumeta H, Funami K, Horiuchi M, Sarmiento J, Yamashita K, Standley DM, Matsumoto M, Seya T, Inagaki F
Proceedings of the National Academy of Sciences of the United States of America 110(49) 19908-19913 2013年12月
The MyD88 pathway in plasmacytoid and CD4+ dendritic cells primarily triggers type I IFN production against measles virus in a mouse infection model.
Takaki H, Takeda M, Tahara M, Shingai M, Oshiumi H, Matsumoto M, Seya T
Journal of immunology (Baltimore, Md. : 1950) 191(9) 4740-4747 2013年11月
Herpesvirus 6 glycoproteins B (gB), gH, gL, and gQ are necessary and sufficient for cell-to-cell fusion.
Tanaka Y, Suenaga T, Matsumoto M, Seya T, Arase H
Journal of virology 87(19) 10900-10903 2013年10月
A distinct role of Riplet-mediated K63-Linked polyubiquitination of the RIG-I repressor domain in human antiviral innate immune responses.
Oshiumi H, Miyashita M, Matsumoto M, Seya T
PLoS pathogens 9(8) e1003533 2013年08月
Hepatitis C virus infection induces inflammatory cytokines and chemokines mediated by the cross talk between hepatocytes and stellate cells.
Nishitsuji H, Funami K, Shimizu Y, Ujino S, Sugiyama K, Seya T, Takaku H, Shimotohno K
Journal of virology 87(14) 8169-8178 2013年07月
Targeting TLR3 with no RIG-I/MDA5 activation is effective in immunotherapy for cancer.
Seya T, Azuma M, Matsumoto M
Expert opinion on therapeutic targets 17(5) 533-544 2013年05月
Toll-like receptor 3 recognizes incomplete stem structures in single-stranded viral RNA.
Tatematsu M, Nishikawa F, Seya T, Matsumoto M
Nature communications 4 1833 2013年05月
Multi-step regulation of interferon induction by hepatitis C virus.
Oshiumi H, Funami K, Aly HH, Matsumoto M, Seya T
Archivum immunologiae et therapiae experimentalis 61(2) 127-138 2013年04月
[Innate immune responses against viral infection and its suppression by viral proteins].
Oshiumi H, Matsumoto M, Seya T
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 133(3) 323-328 2013年03月
Toll-IL-1-receptor-containing adaptor molecule-1: a signaling adaptor linking innate immunity to adaptive immunity.
Matsumoto M, Funami K, Oshiumi H, Seya T
Progress in molecular biology and translational science 117 487-510 2013年
Dendritic Cells from Oral Cavity Induce Foxp3+ Regulatory T Cells upon Antigen Stimulation
Yamazaki S, Maruyama A, Okada K, Matsumoto M, Morita A, Seya T
PLoS ONE 7(12) e51665-e51665 2012年12月
Cleaved/Associated TLR3 Represents the Primary Form of the Signaling Receptor.
Toscano F, Estornes Y, Virard F, Garcia-Cattaneo A, Pierrot A, Vanbervliet B, Bonnin M, Ciancanelli MJ, Zhang SY, Funami K, Seya T, Matsumoto M, Pin JJ, Casanova JL, Renno T, Lebecque S
Journal of immunology (Baltimore, Md. : 1950) 190(2) 764-773 2012年12月
Guideline for Hereditary Angioedema (HAE) 2010 by the Japanese Association for Complement Research - Secondary Publication.
Horiuchi T, Ohi H, Ohsawa I, Fujita T, Matsushita M, Okada N, Seya T, Yamamoto T, Endo Y, Hatanaka M, Wakamiya N, Mizuno M, Nakao M, Okada H, Tsukamoto H, Matsumoto M, Inoue N, Nonaka M, Kinoshita T
Allergology international : official journal of the Japanese Society of Allergology 61(4) 559-562 2012年12月
TAMable tumor-associated macrophages in response to innate RNA sensing.
Seya T, Shime H, Matsumoto M
Oncoimmunology 1(6) 1000-1001 2012年09月
TLR3/TICAM-1 signaling in tumor cell RIP3-dependent necroptosis.
Seya T, Shime H, Takaki H, Azuma M, Oshiumi H, Matsumoto M
Oncoimmunology 1(6) 917-923 2012年09月
Cross-priming for antitumor CTL induced by soluble Ag plus polyI:C depends on the TICAM-1 pathway in mouse CD11c(+)/CD8 alpha(+) dendritic cells
Azuma Masahiro, Ebihara Takashi, Oshiumi Hiroyuki, Matsumoto Misako, Seya Tsukasa
ONCOIMMUNOLOGY 1(5) 581-592 2012年08月
Cross-priming for antitumor CTL induced by soluble Ag + polyI:C depends on the TICAM-1 pathway in mouse CD11c(+)/CD8α(+) dendritic cells.
Azuma M, Ebihara T, Oshiumi H, Matsumoto M, Seya T
Oncoimmunology 1 581-592 2012年08月
[Role of ubiquitin ligase in innate immune response in mammal].
Oshiumi H, Matsumoto M, Seya T
Seikagaku. The Journal of Japanese Biochemical Society 84 455-462 2012年06月
Toll-like receptor 3 signaling converts tumor-supporting myeloid cells to tumoricidal effectors.
Shime H, Matsumoto M, Oshiumi H, Tanaka S, Nakane A, Iwakura Y, Tahara H, Inoue N, Seya T
Proceedings of the National Academy of Sciences of the United States of America 109(6) 2066-2071 2012年02月
The toll-like receptor 3-mediated antiviral response is important for protection against poliovirus infection in poliovirus receptor transgenic mice.
Abe Y, Fujii K, Nagata N, Takeuchi O, Akira S, Oshiumi H, Matsumoto M, Seya T, Koike S
Journal of virology 86(1) 185-194 2012年01月
In vitro models for analysis of the hepatitis C virus life cycle.
Aly HH, Shimotohno K, Hijikata M, Seya T
Microbiology and immunology 56(1) 1-9 2012年01月
Ubiquitin-mediated modulation of the cytoplasmic viral RNA sensor RIG-I.
Oshiumi H, Matsumoto M, Seya T
Journal of biochemistry 151(1) 5-11 2012年01月
TLR3/TICAM-1 signaling converts tumor-supporting myeloid cells to tumoricidal effectors
Proc Natl Acad Sci USA 126 2011 2012年
Dendritic cells from oral cavity induce Foxp3(+) regulatory T cells upon antigen stimulation.
Yamazaki S, Maruyama A, Okada K, Matsumoto M, Morita A, Seya T
PloS one 7 e51665 2012年
UNC93B1 physically associates with human TLR8 and regulates TLR8-mediated signaling.
Itoh H, Tatematsu M, Watanabe A, Iwano K, Funami K, Seya T, Matsumoto M
PloS one 6(12) e28500 2011年12月
Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency.
Sancho-Shimizu V, Pérez de Diego R, Lorenzo L, Halwani R, Alangari A, Israelsson E, Fabrega S, Cardon A, Maluenda J, Tatematsu M, Mahvelati F, Herman M, Ciancanelli M, Guo Y, AlSum Z, Alkhamis N, Al-Makadma AS, Ghadiri A, Boucherit S, Plancoulaine S, Picard C, Rozenberg F, Tardieu M, Lebon P, Jouanguy E, Rezaei N, Seya T, Matsumoto M, Chaussabel D, Puel A, Zhang SY, Abel L, Al-Muhsen S, Casanova JL
The Journal of clinical investigation 121(12) 4889-4902 2011年12月
[Innate immune response to RNA virus infection].
Oshiumi H, Matsumoto M, Seya T
Uirusu 61 153-161 2011年12月
The TLR3/TICAM-1 pathway is mandatory for innate immune responses to poliovirus infection.
Oshiumi H, Okamoto M, Fujii K, Kawanishi T, Matsumoto M, Koike S, Seya T
Journal of immunology (Baltimore, Md. : 1950) 187(10) 5320-5327 2011年11月
Phosphoinositide 3-kinaseγ controls the intracellular localization of CpG to limit DNA-PKcs-dependent IL-10 production in macrophages.
Hazeki K, Kametani Y, Murakami H, Uehara M, Ishikawa Y, Nigorikawa K, Takasuga S, Sasaki T, Seya T, Matsumoto M, Hazeki O
PloS one 6(10) e26836 2011年10月
DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling.
Miyashita M, Oshiumi H, Matsumoto M, Seya T
Molecular and cellular biology 31(18) 3802-3819 2011年09月
Will there be an HCV meeting in 2020? Summary of the 17th international meeting on hepatitis C virus and related viruses.
Wakita T, Suzuki T, Evans MJ, Shimotohno K, Chayama K, Matsuura Y, Hijikata M, Moriishi K, Seya T, Enomoto N, Koike K, Kato N, Kanto T, Hotta H
Gastroenterology 141(1) e1-5 2011年07月
Strain-to-strain difference of V protein of measles virus affects MDA5-mediated IFN-beta-inducing potential (vol 48, pg 497, 2011)
Seya Tsukasa
MOLECULAR IMMUNOLOGY 48(12-13) 1589-1590 2011年07月
Addendum to "Strain-to-strain difference of V protein of measles virus affects MDA5-mediated IFN-β-inducing potential" [Mol. Immunol. 48(4) (2011) 497-504].
Seya T
Molecular immunology 48 1589-1590 2011年07月
Development of mouse hepatocyte lines permissive for hepatitis C virus (HCV).
Aly HH, Oshiumi H, Shime H, Matsumoto M, Wakita T, Shimotohno K, Seya T
PloS one 6(6) e21284 2011年06月
Natural killer cells recognize friend retrovirus-infected erythroid progenitor cells through NKG2D-RAE-1 interactions In Vivo.
Ogawa T, Tsuji-Kawahara S, Yuasa T, Kinoshita S, Chikaishi T, Takamura S, Matsumura H, Seya T, Saga T, Miyazawa M
Journal of virology 85(11) 5423-5435 2011年06月
Development of monoclonal antibodies that specifically interact with necrotic lymphoma cells.
Wakasa K, Shime H, Kurita-Taniguchi M, Matsumoto M, Imamura M, Seya T
Microbiology and immunology 55(5) 373-377 2011年05月
TLR2-dependent induction of IL-10 and Foxp3+ CD25+ CD4+ regulatory T cells prevents effective anti-tumor immunity induced by Pam2 lipopeptides in vivo.
Yamazaki S, Okada K, Maruyama A, Matsumoto M, Yagita H, Seya T
PloS one 6(4) e18833 2011年04月
Failure of mycoplasma lipoprotein MALP-2 to induce NK cell activation through dendritic cell TLR2.
Sawahata R, Shime H, Yamazaki S, Inoue N, Akazawa T, Fujimoto Y, Fukase K, Matsumoto M, Seya T
Microbes and infection / Institut Pasteur 13(4) 350-358 2011年04月
Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation.
Watanabe A, Tatematsu M, Saeki K, Shibata S, Shime H, Yoshimura A, Obuse C, Seya T, Matsumoto M
The Journal of biological chemistry 286(12) 10702-10711 2011年03月
Antiviral responses induced by the TLR3 pathway.
Matsumoto M, Oshiumi H, Seya T
Reviews in medical virology 21(2) 67-77 2011年02月
IL-23-dependent and -independent enhancement pathways of IL-17A production by lactic acid.
Yabu M, Shime H, Hara H, Saito T, Matsumoto M, Seya T, Akazawa T, Inoue N
International immunology 23(1) 29-41 2011年01月
Strain-to-strain difference of V protein of measles virus affects MDA5-mediated IFN-β-inducing potential.
Takaki H, Watanabe Y, Shingai M, Oshiumi H, Matsumoto M, Seya T
Molecular immunology 48(4) 497-504 2011年01月
Lactic acid acts on macrophages to induce antigen-dependent IL-17 production from effector/memory helper T cells
Int. Immunol. 23 29-41 2011年
Raftlin mediates cell entry of poly(I:C) to induce TLR3 activation
J. Biol. Chem.. 286 497-504 2011年
The SKI2-related helicase DDX60 is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling
Molec. Cell. Biol. 31 3802-3819 2011年
Establishing mouse hepatoma cell lines permissive to human hepatitis C virus
PLoS ONE 6 e21284 2011年
ADDENDUM to the paper published in MIMM by Takaki et al
Molec. Immunol. 48 1589-1590 2011年
Human TRIF deficiency in otherwise healthy patients with herpes simplex encephalitis.
J. Clin. Invest 121 4889-4902 2011年
Phosphoinositide 3-kinase controls the intracellular localization of CpG to limit DNA-PKcs-dependent IL-10 production in macrophages
PLoS ONE 6 e26836 2011年
Natural killer cell activation secondary to innate pattern sensing.
Seya T, Kasamatsu J, Azuma M, Shime H, Matsumoto M
Journal of innate immunity 3(3) 264-273 2011年
The ubiquitin ligase Riplet is essential for RIG-I-dependent innate immune responses to RNA virus infection.
Oshiumi H, Miyashita M, Inoue N, Okabe M, Matsumoto M, Seya T
Cell host & microbe 8(6) 496-509 2010年12月
Hepatitis C virus core protein abrogates the DDX3 function that enhances IPS-1-mediated IFN-beta induction.
Oshiumi H, Ikeda M, Matsumoto M, Watanabe A, Takeuchi O, Akira S, Kato N, Shimotohno K, Seya T
PloS one 5(12) e14258 2010年12月
Innate immunity and vaccine.
Seya T
Vaccine 28(50) 8041-8042 2010年11月
Identification of a polyI:C-inducible membrane protein that participates in dendritic cell-mediated natural killer cell activation.
Ebihara T, Azuma M, Oshiumi H, Kasamatsu J, Iwabuchi K, Matsumoto K, Saito H, Taniguchi T, Matsumoto M, Seya T
The Journal of experimental medicine 207(12) 2675-2687 2010年11月
An embryo-specific expressing TGF-β family protein, growth-differentiation factor 3 (GDF3), augments progression of B16 melanoma.
Ehira N, Oshiumi H, Matsumoto M, Kondo T, Asaka M, Seya T
Journal of experimental & clinical cancer research : CR 29 135 2010年10月
The peptide sequence of diacyl lipopeptides determines dendritic cell TLR2-mediated NK activation.
Azuma M, Sawahata R, Akao Y, Ebihara T, Yamazaki S, Matsumoto M, Hashimoto M, Fukase K, Fujimoto Y, Seya T
PloS one 5(9) e12550-e12550 2010年09月
Phylogenetic and expression analysis of lamprey toll-like receptors.
Kasamatsu J, Oshiumi H, Matsumoto M, Kasahara M, Seya T
Developmental and comparative immunology 34(8) 855-865 2010年08月
Adjuvant engineering for cancer immunotherapy: Development of a synthetic TLR2 ligand with increased cell adhesion.
Akazawa T, Inoue N, Shime H, Kodama K, Matsumoto M, Seya T
Cancer science 101(7) 1596-1603 2010年07月
A molecular mechanism for Toll-IL-1 receptor domain-containing adaptor molecule-1-mediated IRF-3 activation.
Tatematsu M, Ishii A, Oshiumi H, Horiuchi M, Inagaki F, Seya T, Matsumoto M
The Journal of biological chemistry 285(26) 20128-20136 2010年06月
[Membrane cofactor protein (MCP, CD46)].
Seya T
Nihon rinsho. Japanese journal of clinical medicine 68 Suppl 6 98-101 2010年06月
[CR1(immune adherence receptor), CR2(EB virus receptor), CR3(Mac-1, CD11b/CD18), CR4(CD11c/CD18)].
Wakasa K, Seya T
Nihon rinsho. Japanese journal of clinical medicine 68 Suppl 6 68-72 2010年06月
DEAD/H BOX 3 (DDX3) helicase binds the RIG-I adaptor IPS-1 to up-regulate IFN-beta-inducing potential.
Oshiumi H, Sakai K, Matsumoto M, Seya T
European journal of immunology 40(4) 940-948 2010年04月
Direct binding of TRAF2 and TRAF6 to TICAM-1/TRIF adaptor participates in activation of the Toll-like receptor 3/4 pathway.
Sasai M, Tatematsu M, Oshiumi H, Funami K, Matsumoto M, Hatakeyama S, Seya T
Molecular immunology 47(6) 1283-1291 2010年03月
Pattern recognition receptors of innate immunity and their application to tumor immunotherapy.
Seya T, Shime H, Ebihara T, Oshiumi H, Matsumoto M
Cancer science 101(2) 313-320 2010年02月
IL-6 and IFN-alpha from dsRNA-stimulated dendritic cells control expansion of regulatory T cells.
Kubota N, Ebihara T, Matsumoto M, Gando S, Seya T
Biochemical and biophysical research communications 391(3) 1421-1426 2010年01月
IL-6 and interferon-alpha induced by polyI:C-stimulated bone-marrow-derived dendritic cells regulate peripheral expansion of regulatory T cells
Biochem. Biophys. Res. Commun. 391 1421-1426 2010年
An embryo-specific expressing TGF-beta family protein, growth-differentiation factor 3 (GDF3), augments progression of B16 melanoma
J. Exp. Clin. Cancer Res. 29 135-135 2010年
Hepatitis C virus (HCV) core protein promotes viral replication by abrogating IFN-β-inducing function of DEAD/H BOX 3 (DDX3) helicase
PLoS ONE 5 e14258-e14258 2010年
Essential role of Riplet in RIG-I-dependent antiviral innate immune responses
Cell host microbe 8 496-509 2010年
Dendritic cell-derived TNF-alpha is responsible for development of IL-10-producing CD4+ T cells.
Hirata N, Yanagawa Y, Satoh M, Ogura H, Ebihara T, Noguchi M, Matsumoto M, Togashi H, Seya T, Onoé K, Iwabuchi K
Cellular immunology 261(1) 37-41 2010年
Oligomerized TICAM-1 (TRIF) in the cytoplasm recruits nuclear BS69 to enhance NF-kappaB activation and type I IFN induction.
Takaki H, Oshiumi H, Sasai M, Kawanishi T, Matsumoto M, Seya T
European journal of immunology 39(12) 3469-3476 2009年12月
Epstein-Barr virus (EBV)-encoded small RNA is released from EBV-infected cells and activates signaling from Toll-like receptor 3.
Iwakiri D, Zhou L, Samanta M, Matsumoto M, Ebihara T, Seya T, Imai S, Fujieda M, Kawa K, Takada K
The Journal of experimental medicine 206(10) 2091-2099 2009年09月
Lipopeptides from Staphylococcus aureus as Tlr2 Ligands: prediction with mrna expression, chemical synthesis, and immunostimulatory activities.
Fujimoto Y, Hashimoto M, Furuyashiki M, Katsumoto M, Seya T, Suda Y, Fukase K
Chembiochem : a European journal of chemical biology 10(14) 2311-2315 2009年09月
Mitofusin 2 inhibits mitochondrial antiviral signaling.
Yasukawa K, Oshiumi H, Takeda M, Ishihara N, Yanagi Y, Seya T, Kawabata S, Koshiba T
Science signaling 2(84) ra47 2009年08月
Enhancement of antitumor natural killer cell activation by orally administered Spirulina extract in mice.
Akao Y, Ebihara T, Masuda H, Saeki Y, Akazawa T, Hazeki K, Hazeki O, Matsumoto M, Seya T
Cancer science 100(8) 1494-1501 2009年08月
The extrinsic RNA-sensing pathway for adjuvant immunotherapy of cancer.
Seya T, Matsumoto M
Cancer immunology, immunotherapy : CII 58(8) 1175-1184 2009年08月
Regulator of complement activation (RCA) gene cluster in Xenopus tropicalis.
Oshiumi H, Suzuki Y, Matsumoto M, Seya T
Immunogenetics 61(5) 371-384 2009年05月
[Role of Toll-like receptors in innate and adaptive immune responses].
Matsumoto M, Seya T
Seikagaku. The Journal of Japanese Biochemical Society 81 156-164 2009年03月
Innate immune therapy with a Bacillus Calmette-Guérin cell wall skeleton after radical surgery for non-small cell lung cancer: a case-control study.
Kodama K, Higashiyama M, Takami K, Oda K, Okami J, Maeda J, Akazawa T, Matsumoto M, Seya T, Wada M, Toyoshima K
Surgery today 39(3) 194-200 2009年03月
Obstructing shedding of the immunostimulatory MHC class I chain-related gene B prevents tumor formation.
Wu JD, Atteridge CL, Wang X, Seya T, Plymate SR
Clinical cancer research : an official journal of the American Association for Cancer Research 15(2) 632-640 2009年01月
Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection.
Oshiumi H, Matsumoto M, Hatakeyama S, Seya T
The Journal of biological chemistry 284(2) 807-817 2009年01月
Functional evolution of the TICAM-1 pathway for extrinsic RNA sensing.
Seya T, Matsumoto M, Ebihara T, Oshiumi H
Immunological reviews 227 44-53 2009年01月
Innate immune therapy with a BCG cell wall skeleton for lung cancer: a case presentation and a case control study.
Surgery Today 39 194-200 2009年
Innate Immunostimulatory lipopepitdes of Staphylococcus aureus as TLR2 ligands; Prediction with mRNA expression, chemical synthesis and immunostimulatory activities.
Chem. Biol. Chem. 10 2311-2315 2009年
Mitofusin 2, a mitochondrial fusion mediator, acts as a negative regulator for mitochondrial antiviral signaling.
Science Signaling. 2 47 2009年
Isolation and Characterization of RNA aptamers specific for the human Toll-like receptor 3 ectodomain
Viva Organo 37 10-18 2009年
Cytoplasmic oligomerized TICAM-1 recruits nuclear BS69 to enhance type I interferon induction.
Eur. J. Immunol. 39 3469-3476 2009年
Pan-vertebrate toll-like receptors during evolution.
Oshiumi H, Matsuo A, Matsumoto M, Seya T
Current genomics 9(7) 488-493 2008年11月
The clathrin-mediated endocytic pathway participates in dsRNA-induced IFN-beta production.
Itoh K, Watanabe A, Funami K, Seya T, Matsumoto M
Journal of immunology (Baltimore, Md. : 1950) 181(8) 5522-5529 2008年10月
Teleost TLR22 recognizes RNA duplex to induce IFN and protect cells from birnaviruses.
Matsuo A, Oshiumi H, Tsujita T, Mitani H, Kasai H, Yoshimizu M, Matsumoto M, Seya T
Journal of immunology (Baltimore, Md. : 1950) 181(5) 3474-3485 2008年09月
Soluble G protein of respiratory syncytial virus inhibits Toll-like receptor 3/4-mediated IFN-beta induction.
Shingai M, Azuma M, Ebihara T, Sasai M, Funami K, Ayata M, Ogura H, Tsutsumi H, Matsumoto M, Seya T
International immunology 20(9) 1169-1180 2008年09月
Modulation of double-stranded RNA recognition by the N-terminal histidine-rich region of the human toll-like receptor 3.
Fukuda K, Watanabe T, Tokisue T, Tsujita T, Nishikawa S, Hasegawa T, Seya T, Matsumoto M
The Journal of biological chemistry 283(33) 22787-22794 2008年08月
Hepatitis C virus-infected hepatocytes extrinsically modulate dendritic cell maturation to activate T cells and natural killer cells.
Ebihara T, Shingai M, Matsumoto M, Wakita T, Seya T
Hepatology (Baltimore, Md.) 48(1) 48-58 2008年07月
Homo-oligomerization is essential for Toll/interleukin-1 receptor domain-containing adaptor molecule-1-mediated NF-kappaB and interferon regulatory factor-3 activation.
Funami K, Sasai M, Oshiumi H, Seya T, Matsumoto M
The Journal of biological chemistry 283(26) 18283-18291 2008年06月
Tumor-secreted lactic acid promotes IL-23/IL-17 proinflammatory pathway.
Shime H, Yabu M, Akazawa T, Kodama K, Matsumoto M, Seya T, Inoue N
Journal of immunology (Baltimore, Md. : 1950) 180(11) 7175-7183 2008年06月
HCV and innate immunity.
Ebihara T, Matsumoto M, Seya T
Uirusu 58 19-26 2008年06月
Increased expression of Toll-like receptor 3 in intrahepatic biliary epithelial cells at sites of ductular reaction in diseased livers.
Nakamura M, Funami K, Komori A, Yokoyama T, Aiba Y, Araki A, Takii Y, Ito M, Matsuyama M, Koyabu M, Migita K, Taniguchi K, Fujioka H, Yatsuhashi H, Matsumoto M, Ishibashi H, Seya T
Hepatology international 2(2) 222-230 2008年06月
Selective synergy in anti-inflammatory cytokine production upon cooperated signaling via TLR4 and TLR2 in murine conventional dendritic cells.
Hirata N, Yanagawa Y, Ebihara T, Seya T, Uematsu S, Akira S, Hayashi F, Iwabuchi K, Onoé K
Molecular immunology 45(10) 2734-2742 2008年05月
TLR3: interferon induction by double-stranded RNA including poly(I:C).
Matsumoto M, Seya T
Advanced drug delivery reviews 60(7) 805-812 2008年04月
Toll-like receptor and pattern sensing for evoking immune response.
Seya T
Advanced drug delivery reviews 60(7) 779-781 2008年04月
The proinflammatory cytokine response to Chlamydia trachomatis elementary bodies in human macrophages is partly mediated by a lipoprotein, the macrophage infectivity potentiator, through TLR2/TLR1/TLR6 and CD14.
Bas S, Neff L, Vuillet M, Spenato U, Seya T, Matsumoto M, Gabay C
Journal of immunology (Baltimore, Md. : 1950) 180(2) 1158-1168 2008年01月
Hepatitis C virus (HCV)-infected hepatocytes extrinsically modulate dendritic cell maturation to activate T cells and natural killer cells.
Hepatology. 48 48-58 2008年
Combinational recognition of bacterial lipoproteins and peptidoglycan by chicken Toll-like receptor 2 subfamily.
Higuchi M, Matsuo A, Shingai M, Shida K, Ishii A, Funami K, Suzuki Y, Oshiumi H, Matsumoto M, Seya T
Developmental and comparative immunology 32(2) 147-155 2008年
The clathrin-mediated endocytic pathway participates in dsRNA-induced IFN-b production.
J. Immunol. 181 5522-5529 2008年
Significance of the N-terminal histidine-rich region for the function of the human toll-like receptor 3 ectodomain.
Tokisue T, Watanabe T, Tsujita T, Nishikawa S, Hasegawa T, Seya T, Matsumoto M, Fukuda K
Nucleic acids symposium series (2004)  203-204 2008年
Effect of the alterations in the fusion protein of measles virus isolated from brains of patients with subacute sclerosing panencephalitis on syncytium formation.
Ayata M, Shingai M, Ning X, Matsumoto M, Seya T, Otani S, Seto T, Ohgimoto S, Ogura H
Virus research 130(1-2) 260-268 2007年12月
Recombinant interleukin-12 and interleukin-18 antitumor therapy in a guinea-pig hepatoma cell implant model.
Shiratori I, Suzuki Y, Oshiumi H, Begum NA, Ebihara T, Matsumoto M, Hazeki K, Kodama K, Kashiwazaki Y, Seya T
Cancer science 98(12) 1936-1942 2007年12月
Spatiotemporal mobilization of Toll/IL-1 receptor domain-containing adaptor molecule-1 in response to dsRNA.
Funami K, Sasai M, Ohba Y, Oshiumi H, Seya T, Matsumoto M
Journal of immunology (Baltimore, Md. : 1950) 179(10) 6867-6872 2007年11月
Differential type I IFN-inducing abilities of wild-type versus vaccine strains of measles virus.
Shingai M, Ebihara T, Begum NA, Kato A, Honma T, Matsumoto K, Saito H, Ogura H, Matsumoto M, Seya T
Journal of immunology (Baltimore, Md. : 1950) 179(9) 6123-6133 2007年11月
Induction of NKG2D ligands on human dendritic cells by TLR ligand stimulation and RNA virus infection.
Ebihara T, Masuda H, Akazawa T, Shingai M, Kikuta H, Ariga T, Matsumoto M, Seya T
International immunology 19(10) 1145-1155 2007年10月
Lipoteichoic acid downregulates FcepsilonRI expression on human mast cells through Toll-like receptor 2.
Yoshioka M, Fukuishi N, Iriguchi S, Ohsaki K, Yamanobe H, Inukai A, Kurihara D, Imajo N, Yasui Y, Matsui N, Tsujita T, Ishii A, Seya T, Takahama M, Akagi M
The Journal of allergy and clinical immunology 120(2) 452-461 2007年08月
Tumor immunotherapy using bone marrow-derived dendritic cells overexpressing Toll-like receptor adaptors.
Akazawa T, Shingai M, Sasai M, Ebihara T, Inoue N, Matsumoto M, Seya T
FEBS letters 581(18) 3334-3340 2007年07月
C-terminal LRRs of human Toll-like receptor 3 control receptor dimerization and signal transmission.
Takada E, Okahira S, Sasai M, Funami K, Seya T, Matsumoto M
Molecular immunology 44(15) 3633-3640 2007年07月
Phylogenetic and expression analysis of amphibian Xenopus Toll-like receptors.
Ishii Akihiro, Kawasaki Miyuki, Matsumoto Misako, Tochinai Shin, Seya Tsukasa
Immunogenetics 59(4) 281-293 2007年04月
Inhibition of lipid A-mediated type I interferon induction by bactericidal/permeability-increasing protein (BPI).
Azuma M, Matsuo A, Fujimoto Y, Fukase K, Hazeki K, Hazeki O, Matsumoto M, Seya T
Biochemical and biophysical research communications 354(2) 574-578 2007年03月
Protein kinase Cdelta binds TIRAP/Mal to participate in TLR signaling.
Kubo-Murai M, Hazeki K, Sukenobu N, Yoshikawa K, Nigorikawa K, Inoue K, Yamamoto T, Matsumoto M, Seya T, Inoue N, Hazeki O
Molecular immunology 44(9) 2257-2264 2007年03月
Antitumor NK activation induced by the Toll-like receptor 3-TICAM-1 (TRIF) pathway in myeloid dendritic cells.
Akazawa T, Ebihara T, Okuno M, Okuda Y, Shingai M, Tsujimura K, Takahashi T, Ikawa M, Okabe M, Inoue N, Okamoto-Tanaka M, Ishizaki H, Miyoshi J, Matsumoto M, Seya T
Proceedings of the National Academy of Sciences of the United States of America 104(1) 252-257 2007年01月
TLR3-mediated synthesis and release of eotaxin-1/CCL11 from human bronchial smooth muscle cells stimulated with double-stranded RNA.
Niimi K, Asano K, Shiraishi Y, Nakajima T, Wakaki M, Kagyo J, Takihara T, Suzuki Y, Fukunaga K, Shiomi T, Oguma T, Sayama K, Yamaguchi K, Natori Y, Matsumoto M, Seya T, Yamaya M, Ishizaka A
Journal of immunology (Baltimore, Md. : 1950) 178(1) 489-495 2007年01月
Lamprey TLRs with properties distinct from those of the variable lymphocyte receptors.
Ishii A, Matsuo A, Sawa H, Tsujita T, Shida K, Matsumoto M, Seya T
Journal of immunology (Baltimore, Md. : 1950) 178(1) 397-406 2007年01月
Lamprey Toll-like receptors with properties distinct from those of variable lymphocyte receptors.
J. Immunol. 178 397-406 2007年
Toll-like receptor 3-mediated synthesis and release of eotaxin-1/CCL11 from human bronchial smooth muscle cells stimulated with double-stranded RNA.
J. Immunol. 178 489-495 2007年
Protein kinase Cdelta binds TIRAP/Mal to participate in Toll-like receptor signaling.
Molec. Immunol. 44 2257-2264 2007年
Differential type I interferon (IFN) inducing abilities of wild-type vs. vaccine strains of measles virus.
J. Immunol. 179 6123-6133 2007年
NKG2D ligands are induced on human dendritic cells by TLR ligand stimulation and RNA virus infection.
Int. Immunol. 19 1145-1155 2007年
Lipoteichoic acid down-regulates Fce receptor I expression on human mast cells through Toll-like receptor 2.
J. Aller. Clin. Immunol. 120 452-461 2007年
Spatiotemporal mobilization of Toll/1L-1 receptor domain-containing adaptor molecule-1 in response to dsRNA.
J Immunol. 179 6867-6872 2007年
N-terminal binding site in the human toll-like receptor 3 ectodomain.
Watanabe T, Tokisue T, Tsujita T, Matsumoto M, Seya T, Nishikawa S, Hasegawa T, Fukuda K
Nucleic acids symposium series (2004)  405-406 2007年
NAK-associated protein 1 participates in both the TLR3 and the cytoplasmic pathways in type I IFN induction.
Sasai M, Shingai M, Funami K, Yoneyama M, Fujita T, Matsumoto M, Seya T
Journal of immunology (Baltimore, Md. : 1950) 177(12) 8676-8683 2006年12月
Intelectin: a novel lipid raft-associated protein in the enterocyte brush border.
Wrackmeyer U, Hansen GH, Seya T, Danielsen EM
Biochemistry 45(30) 9188-9197 2006年08月
The short consensus repeats 1 and 2, not the cytoplasmic domain, of human CD46 are crucial for infection of subgroup B adenovirus serotype 35.
Sakurai F, Murakami S, Kawabata K, Okada N, Yamamoto A, Seya T, Hayakawa T, Mizuguchi H
Journal of controlled release : official journal of the Controlled Release Society 113(3) 271-278 2006年07月
A novel cyclohexene derivative, ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), selectively inhibits toll-like receptor 4-mediated cytokine production through suppression of intracellular signaling.
Ii M, Matsunaga N, Hazeki K, Nakamura K, Takashima K, Seya T, Hazeki O, Kitazaki T, Iizawa Y
Molecular pharmacology 69 1288-1295 2006年04月
Role of Toll-like receptors in adjuvant-augmented immune therapies.
Seya T, Akazawa T, Tsujita T, Matsumoto M
Evidence-based complementary and alternative medicine : eCAM 3 31-8; discussion 133 2006年03月
The kinase complex responsible for IRF-3-mediated IFN-beta production in myeloid dendritic cells (mDC).
Sasai M, Matsumoto M, Seya T
Journal of biochemistry 139 171-175 2006年02月
Physical and functional interactions between STAT3 and Kaposi's sarcoma-associated herpesvirus-encoded LANA.
Muromoto R, Okabe K, Fujimuro M, Sugiyama K, Yokosawa H, Seya T, Matsuda T
FEBS letters 580(1) 93-98 2006年01月
Fish soluble Toll-like receptor (TLR)5 amplifies human TLR5 response via physical binding to flagellin.
Vaccine 24 2193-2199 2006年
A novel cyclohexene derivative, ethyl(6R)6- [N-(2-Chloro-4-fluorophenyl) sulfamoyl] cyclonex-1-ene-1-carboxylate, TAK-242, selectively inhibits Toll-like receptor 4-mediated cytokine production through suppression of intracellular signaling.
Mol Pharmacol. 69 1288-1295 2006年
NAP1 (NAK-associated protein 1) participates in both the TLR3 and the cytoplasmic pathways in type I interferon induction.
J. Immunol. 177 8676-8683 2006年
Isolation of RNA aptamers against human Toll-like receptor 3 ectodomain.
Watanabe T, Ito K, Matsumoto M, Seya T, Nishikawa S, Hasegawa T, Fukuda K
Nucleic acids symposium series (2004)  251-252 2006年
Analysis of the interaction between human TLR3 ectodomain and nucleic acids.
Fukuda K, Tsujita T, Matsumoto M, Seya T, Sakiyama H, Nishikawa F, Nishikawa S, Hasegawa T
Nucleic acids symposium series (2004)  249-250 2006年
Differential-expression and tyrosine-phosphorylation profiles of caveolin isoforms in human T cell leukemia cell lines.
Tsuji Y, Hatanaka M, Maeda T, Seya T, Takenaka H, Shimizu A
International journal of molecular medicine 16 889-893 2005年11月
Interferon-beta induction through toll-like receptor 3 depends on double-stranded RNA structure.
Okahira S, Nishikawa F, Nishikawa S, Akazawa T, Seya T, Matsumoto M
DNA and cell biology 24 614-623 2005年10月
Wild-type measles virus infection in human CD46/CD150-transgenic mice: CD11c-positive dendritic cells establish systemic viral infection.
Shingai M, Inoue N, Okuno T, Okabe M, Akazawa T, Miyamoto Y, Ayata M, Honda K, Kurita-Taniguchi M, Matsumoto M, Ogura H, Taniguchi T, Seya T
Journal of immunology (Baltimore, Md. : 1950) 175 3252-3261 2005年09月
Pathways participating in activation of mouse uterine natural killer cells during pregnancy.
Xie X, He H, Colonna M, Seya T, Takai T, Croy BA
Biology of reproduction 73 510-518 2005年09月
Regulator of complement activation (RCA) locus in chicken: identification of chicken RCA gene cluster and functional RCA proteins.
Oshiumi H, Shida K, Goitsuka R, Kimura Y, Katoh J, Ohba S, Tamaki Y, Hattori T, Yamada N, Inoue N, Matsumoto M, Mizuno S, Seya T
Journal of immunology (Baltimore, Md. : 1950) 175 1724-1734 2005年08月
[Immunologic tests: Membrane cofactor protein (MCP, CD46)].
Shingai M, Seya T
Nihon rinsho. Japanese journal of clinical medicine 63 Suppl 7 95-97 2005年07月
[Immunologic tests: CR3 (Mac-1, CD11b/CD18), CR4 (CD11c/CD18)].
Funami K, Seya T
Nihon rinsho. Japanese journal of clinical medicine 63 Suppl 7 71-73 2005年07月
[Immunologic tests: C3 receptor (CR1, 2)].
Okuda N, Seya T
Nihon rinsho. Japanese journal of clinical medicine 63 Suppl 7 67-70 2005年07月
Dendritic cell maturation induced by muramyl dipeptide (MDP) derivatives: monoacylated MDP confers TLR2/TLR4 activation.
Uehori J, Fukase K, Akazawa T, Uematsu S, Akira S, Funami K, Shingai M, Matsumoto M, Azuma I, Toyoshima K, Kusumoto S, Seya T
Journal of immunology (Baltimore, Md. : 1950) 174 7096-7103 2005年06月
Gene-inducing program of human dendritic cells in response to BCG cell-wall skeleton (CWS), which reflects adjuvancy required for tumor immunotherapy.
Ishii K, Kurita-Taniguchi M, Aoki M, Kimura T, Kashiwazaki Y, Matsumoto M, Seya T
Immunology letters 98 280-290 2005年05月
Identification of intelectin overexpression in malignant pleural mesothelioma by serial analysis of gene expression (SAGE).
Wali A, Morin PJ, Hough CD, Lonardo F, Seya T, Carbone M, Pass HI
Lung cancer (Amsterdam, Netherlands) 48 19-29 2005年04月
Fish soluble Toll-like receptor 5 (TLR5S) is an acute-phase protein with integral flagellin-recognition activity.
Tsukada H, Fukui A, Tsujita T, Matsumoto M, Iida T, Seya T
International journal of molecular medicine 15 519-525 2005年03月
TICAM-1 and TICAM-2: toll-like receptor adapters that participate in induction of type 1 interferons.
Seya T, Oshiumi H, Sasai M, Akazawa T, Matsumoto M
The international journal of biochemistry & cell biology 37 524-529 2005年03月
Surface-expressed TLR6 participates in the recognition of diacylated lipopeptide and peptidoglycan in human cells.
Nakao Y, Funami K, Kikkawa S, Taniguchi M, Nishiguchi M, Fukumori Y, Seya T, Matsumoto M
Journal of immunology (Baltimore, Md. : 1950) 174 1566-1573 2005年02月
Cutting Edge: NF-kappaB-activating kinase-associated protein 1 participates in TLR3/Toll-IL-1 homology domain-containing adapter molecule-1-mediated IFN regulatory factor 3 activation.
Sasai M, Oshiumi H, Matsumoto M, Inoue N, Fujita F, Nakanishi M, Seya T
Journal of immunology (Baltimore, Md. : 1950) 174 27-30 2005年01月
Cutting Edge: NF-kB-activating kinase-associated protein 1 participates in TLR3/Toll-IL-1 homology domain-containing adapter molecule-1-mediated IFN Regulatory Factor 3 activation.
J. Immunol. 174 27-30 2005年
Wild-type measles virus infection in human CD46/CD150-trangenic mice: CD11c-positive dendritic establish systemic viral infection.
J. Immunol. 175 3252-3261 2005年
Interferon-b induction through Toll-like receptor 3 depends on double-stranded RNA structure.
DNA Cell Biol. 24 614-623 2005年
Antibodies against human Toll-like receptors (TLRs): TLR distribution and localization in human dendritic cells.
Seya T, Funami K, Taniguchi M, Matsumoto M
Journal of endotoxin research 11 369-374 2005年
Functional assays for putative immunological cytolitic gene of H-roretzi
Kimura Avuko, Endo Kazuyuki, Yoshizaki Fumiko, Miyazawa Seita, Seya Tsukasa, Fukuhara Takeshi, Nonaka Masaru
ZOOLOGICAL SCIENCE 21(12) 1319 2004年12月
Sensing bacterial flagellin by membrane and soluble orthologs of Toll-like receptor 5 in rainbow trout (Onchorhynchus mikiss).
Tsujita T, Tsukada H, Nakao M, Oshiumi H, Matsumoto M, Seya T
The Journal of biological chemistry 279(47) 48588-48597 2004年11月
The cytoplasmic 'linker region' in Toll-like receptor 3 controls receptor localization and signaling.
Funami K, Matsumoto M, Oshiumi H, Akazawa T, Yamamoto A, Seya T
International immunology 16 1143-1154 2004年08月
A short consensus repeat-containing complement regulatory protein of lamprey that participates in cleavage of lamprey complement 3.
Kimura Y, Inoue N, Fukui A, Oshiumi H, Matsumoto M, Nonaka M, Kuratani S, Fujita T, Nonaka M, Seya T
Journal of immunology (Baltimore, Md. : 1950) 173 1118-1128 2004年07月
[Toll-like receptors that sense viral infection].
Seya T, Shingai M, Matsumoto M
Uirusu 54 1-8 2004年06月
Mycobacterium bovis BCG cell wall-specific differentially expressed genes identified by differential display and cDNA subtraction in human macrophages.
Begum NA, Ishii K, Kurita-Taniguchi M, Tanabe M, Kobayashi M, Moriwaki Y, Matsumoto M, Fukumori Y, Azuma I, Toyoshima K, Seya T
Infection and immunity 72 937-948 2004年02月
Adjuvant-mediated tumor regression and tumor-specific cytotoxic response are impaired in MyD88-deficient mice.
Akazawa T, Masuda H, Saeki Y, Matsumoto M, Takeda K, Tsujimura K, Kuzushima K, Takahashi T, Azuma I, Akira S, Toyoshima K, Seya T
Cancer research 64 757-764 2004年01月
Mycobacterium bovis BCG cell wall-spacific of differentially expressed genes identified by differential display and cDNA subtraction in human macrophages.
Infect. Immun. 72 937-948 2004年
Infection of different cell lines of neural origin with subacute sclerosing panencephalitis (SSPE) virus.
Ishida H, Ayata M, Shingai M, Matsunaga I, Seto Y, Katayama Y, Iritani N, Seya T, Yanagi Y, Matsuoka O, Yamano T, Ogura H
Microbiology and immunology 48 277-287 2004年
Toll-like receptor 3: a link between toll-like receptor, interferon and viruses.
Matsumoto M, Funami K, Oshiumi H, Seya T
Microbiology and immunology 48 147-154 2004年
TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta.
Oshiumi H, Sasai M, Shida K, Fujita T, Matsumoto M, Seya T
The Journal of biological chemistry 278 49751-49762 2003年12月
Role of toll-like receptors and their adaptors in adjuvant immunotherapy for cancer.
Seya T, Akazawa T, Uehori J, Matsumoto M, Azuma I, Toyoshima K
Anticancer research 23 4369-4376 2003年11月
Mechanism of up-regulation of human Toll-like receptor 3 secondary to infection of measles virus-attenuated strains.
Tanabe M, Kurita-Taniguchi M, Takeuchi K, Takeda M, Ayata M, Ogura H, Matsumoto M, Seya T
Biochemical and biophysical research communications 311 39-48 2003年11月
Selective contribution of IFN-alpha/beta signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection.
Honda K, Sakaguchi S, Nakajima C, Watanabe A, Yanai H, Matsumoto M, Ohteki T, Kaisho T, Takaoka A, Akira S, Seya T, Taniguchi T
Proceedings of the National Academy of Sciences of the United States of America 100 10872-10877 2003年09月
Subcellular localization of Toll-like receptor 3 in human dendritic cells.
Matsumoto M, Funami K, Tanabe M, Oshiumi H, Shingai M, Seto Y, Yamamoto A, Seya T
Journal of immunology (Baltimore, Md. : 1950) 171 3154-3162 2003年09月
Simultaneous blocking of human Toll-like receptors 2 and 4 suppresses myeloid dendritic cell activation induced by Mycobacterium bovis bacillus Calmette-Guérin peptidoglycan.
Uehori J, Matsumoto M, Tsuji S, Akazawa T, Takeuchi O, Akira S, Kawata T, Azuma I, Toyoshima K, Seya T
Infection and immunity 71 4238-4249 2003年08月
Receptor use by vesicular stomatitis virus pseudotypes with glycoproteins of defective variants of measles virus isolated from brains of patients with subacute sclerosing panencephalitis.
Shingai M, Ayata M, Ishida H, Matsunaga I, Katayama Y, Seya T, Tatsuo H, Yanagi Y, Ogura H
The Journal of general virology 84 2133-2143 2003年08月
Down-regulation of Toll-like receptor expression in monocyte-derived Langerhans cell-like cells: implications of low-responsiveness to bacterial components in the epidermal Langerhans cells.
Takeuchi J, Watari E, Shinya E, Norose Y, Matsumoto M, Seya T, Sugita M, Kawana S, Takahashi H
Biochemical and biophysical research communications 306 674-679 2003年07月
Disruption of mouse CD46 causes an accelerated spontaneous acrosome reaction in sperm.
Inoue N, Ikawa M, Nakanishi T, Matsumoto M, Nomura M, Seya T, Okabe M
Molecular and cellular biology 23 2614-2622 2003年04月
Toll-like receptor-mediated tyrosine phosphorylation of paxillin via MyD88-dependent and -independent pathways.
Hazeki K, Masuda N, Funami K, Sukenobu N, Matsumoto M, Akira S, Takeda K, Seya T, Hazeki O
European journal of immunology 33 740-747 2003年03月
Prediction of the prototype of the human Toll-like receptor gene family from the pufferfish, Fugu rubripes, genome.
Oshiumi H, Tsujita T, Shida K, Matsumoto M, Ikeo K, Seya T
Immunogenetics 54 791-800 2003年02月
TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction.
Oshiumi H, Matsumoto M, Funami K, Akazawa T, Seya T
Nature immunology 4 161-167 2003年02月
Mycobacterium bovis BCG cell wall and lipopolysaccharide induce a novel gene, BIGM103, encoding a 7-TM protein: identification of a new protein family having Zn-transporter and Zn-metalloprotease signatures.
Begum NA, Kobayashi M, Moriwaki Y, Matsumoto M, Toyoshima K, Seya T
Genomics 80 630-645 2002年12月
Mapping of the sites responsible for factor I-cofactor activity for cleavage of C3b and C4b on human C4b-binding protein (C4bp) by deletion mutagenesis.
Fukui A, Yuasa-Nakagawa T, Murakami Y, Funami K, Kishi N, Matsuda T, Fujita T, Seya T, Nagasawa S
Journal of biochemistry 132 719-728 2002年11月
Mechanism of host cell protection from complement in murine cytomegalovirus (CMV) infection: identification of a CMV-responsive element in the CD46 promoter region.
Nomura M, Kurita-Taniguchi M, Kondo K, Inoue N, Matsumoto M, Yamanishi K, Okabe M, Seya T
European journal of immunology 32 2954-2964 2002年10月
[RNA interference for mammalian cells].
Oshiumi H, Begum NA, Matsumoto M, Seya T
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 120 91-95 2002年08月
A lipoprotein family from Mycoplasma fermentans confers host immune activation through Toll-like receptor 2.
Seya T, Matsumoto M
The international journal of biochemistry & cell biology 34 901-906 2002年08月
Susceptibility of human dendritic cells (DCs) to measles virus (MV) depends on their activation stages in conjunction with the level of CDw150: role of Toll stimulators in DC maturation and MV amplification.
Murabayashi N, Kurita-Taniguchi M, Ayata M, Matsumoto M, Ogura H, Seya T
Microbes and infection / Institut Pasteur 4 785-794 2002年07月
Structural-functional relationship of pathogen-associated molecular patterns: lessons from BCG cell wall skeleton and mycoplasma lipoprotein M161Ag.
Seya T, Matsumoto M, Tsuji S, Begum NA, Azuma I, Toyoshima K
Microbes and infection / Institut Pasteur 4 955-961 2002年07月
Ligation of human CD46 with purified complement C3b or F(ab')(2) of monoclonal antibodies enhances isoform-specific interferon gamma-dependent nitric oxide production in macrophages.
Hirano A, Kurita-Taniguchi M, Katayama Y, Matsumoto M, Wong TC, Seya T
Journal of biochemistry 132 83-91 2002年07月
Human herpesvirus 6 variant A but not variant B induces fusion from without in a variety of human cells through a human herpesvirus 6 entry receptor, CD46.
Mori Y, Seya T, Huang HL, Akkapaiboon P, Dhepakson P, Yamanishi K
Journal of virology 76 6750-6761 2002年07月
Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling.
Matsumoto M, Kikkawa S, Kohase M, Miyake K, Seya T
Biochemical and biophysical research communications 293 1364-1369 2002年05月
Activation of the human innate immune system by Spirulina: augmentation of interferon production and NK cytotoxicity by oral administration of hot water extract of Spirulina platensis.
Hirahashi T, Matsumoto M, Hazeki K, Saeki Y, Ui M, Seya T
International immunopharmacology 2 423-434 2002年03月
Transgenic pigs expressing human decay-accelerating factor regulated by porcine MCP gene promoter.
Murakami H, Nagashima H, Takahagi Y, Miyagawa S, Fujimura T, Toyomura K, Nakai R, Yamada M, Kurihara T, Shigehisa T, Okabe M, Seya T, Shirakura R, Kinoshita T
Molecular reproduction and development 61 302-311 2002年03月
Molecular assembly of CD46 with CD9, alpha3-beta1 integrin and protein tyrosine phosphatase SHP-1 in human macrophages through differentiation by GM-CSF.
Kurita-Taniguchi M, Hazeki K, Murabayashi N, Fukui A, Tsuji S, Matsumoto M, Toyoshima K, Seya T
Molecular immunology 38 689-700 2002年02月
High levels of RAE-1 isoforms on mouse tumor cell lines assessed by anti-"pan" RAE-1 antibody confer tumor susceptibility to NK cells.
Masuda H, Saeki Y, Nomura M, Shida K, Matsumoto M, Ui M, Lanier LL, Seya T
Biochemical and biophysical research communications 290 140-145 2002年01月

作品等

21世紀COEプログラム<バイオとナノを融合する新生命科学拠点>シンポジウム「創薬を目指したケミカルバイオロジー研究の最前線」(札幌):合成ワクチンアジュバントによる樹状細胞の機能分化(特別講演)
2005年 
作品等を全て表示する
作品等閉じる
21世紀COEプログラム<バイオとナノを融合する新生命科学拠点>シンポジウム「創薬を目指したケミカルバイオロジー研究の最前線」(札幌):合成ワクチンアジュバントによる樹状細胞の機能分化(特別講演)
2005年 

特許

免疫応答を惹起するための新規アジュバントおよびその利用
diRNAを有効成分とする免疫治療用薬剤
I型インターフェロンの発現調節剤
アジュバント活性を有する新規核酸およびその利用
瀬谷 司
特願2012-526535
アジュバント組成物
瀬谷 司
特願2014-244421
がん免疫アジュバント
瀬谷 司
特願2016-147657
特許を全て表示する
特許閉じる
免疫応答を惹起するための新規アジュバントおよびその利用
diRNAを有効成分とする免疫治療用薬剤
I型インターフェロンの発現調節剤
アジュバント活性を有する新規核酸およびその利用
瀬谷 司
特願2012-526535
アジュバント組成物
瀬谷 司
特願2014-244421
がん免疫アジュバント
瀬谷 司
特願2016-147657

受賞

2015年
黒住財団 小島三郎記念医学賞 
2015年
北海道医師会 北海道医師会医学賞 
2014年
北海道庁 北海道科学技術賞 
2006年
武田科学振興財団研究助成金(一般研究奨励) 
2005年
三菱財団研究奨励賞 
2003年
高松宮妃がん研究奨励賞 
受賞を全て表示する
受賞閉じる
2015年
黒住財団 小島三郎記念医学賞 
2015年
北海道医師会 北海道医師会医学賞 
2014年
北海道庁 北海道科学技術賞 
2006年
武田科学振興財団研究助成金(一般研究奨励) 
2005年
三菱財団研究奨励賞 
2003年
高松宮妃がん研究奨励賞 

競争的資金等の研究課題

自然免疫
:JST戦略的創造研究推進制度(研究チーム型) (戦略的基礎研究推進事業:CREST)
研究期間 : 1979年
競争的資金等の研究課題を全て表示する
競争的資金等の研究課題閉じる
自然免疫
:JST戦略的創造研究推進制度(研究チーム型) (戦略的基礎研究推進事業:CREST)
研究期間 : 1979年

社会貢献

委員歴

2008年
日本免疫学会 広報委員
委員歴を全て表示する
委員歴閉じる
2008年
日本免疫学会 広報委員

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