西村 紳一郎ニシムラ シンイチロウresearchmap個人ページ

更新日 : 2018/01/23

基本情報

プロフィール

所属部署名
先端生命科学研究院 先端融合科学研究部門 新薬探索研究分野
職名教授 
学位
理学博士(北海道大学)
メールアドレス
ホームページURLhttp://altair.sci.hokudai.ac.jp/g4/index.html
科研費研究者番号
  • 複合糖質の構造と機能の解明を通して新しい医薬品開発に貢献できればと考えております。

研究キーワード

包括脳ネットワーク, 合成化学, 生体関連化学

研究分野

複合化学 / 合成化学
複合化学 / 生体関連化学
研究分野を全て表示する
研究分野閉じる
複合化学 / 合成化学
複合化学 / 生体関連化学

所属学協会

高分子学会
日本化学会
日本化学会生体機能関連化学部会委員
日本学術振興会
アメリカ化学会
日本バイオマテリアル学会
日本学術会議
所属学協会を全て表示する
所属学協会閉じる
高分子学会
日本化学会
日本化学会生体機能関連化学部会委員
日本学術振興会
アメリカ化学会
日本バイオマテリアル学会
日本学術会議

研究活動

論文

Rapid and high-throughput N-glycomic analysis of plant glycoproteins.
Kaneko K, Shiraya T, Mitsui T, Nishimura S
Methods in molecular biology (Clifton, N.J.) 1072 645-653 2014年
Clinical utility of high-throughput glycome analysis in patients with pancreatic cancer.
Nouso K, Amano M, Ito YM, Miyahara K, Morimoto Y, Kato H, Tsutsumi K, Tomoda T, Yamamoto N, Nakamura S, Kobayashi S, Kuwaki K, Hagihara H, Onishi H, Miyake Y, Ikeda F, Shiraha H, Takaki A, Nakahara T, Nishimura S, Yamamoto K
Journal of gastroenterology 48 1171-1179 2013年10月
Serum glycan markers for evaluation of disease activity and prediction of clinical course in patients with ulcerative colitis.
Miyahara K, Nouso K, Saito S, Hiraoka S, Harada K, Takahashi S, Morimoto Y, Kobayashi S, Ikeda F, Miyake Y, Shiraha H, Takaki A, Okada H, Amano M, Hirose K, Nishimura S, Yamamoto K
PloS one 8 e74861 2013年10月
Serum N-glycan alteration associated with renal cell carcinoma detected by high-throughput glycan analysis.
Hatakeyama S, Amano M, Tobisawa Y, Yoneyama T, Tsuchiya N, Habuchi T, Nishimura SI, Ohyama C
The Journal of urology 2013年10月
Discovery of novel differentiation markers in the early stage of chondrogenesis by glycoform-focused reverse proteomics and genomics.
Ishihara T, Kakiya K, Takahashi K, Miwa H, Rokushima M, Yoshinaga T, Tanaka Y, Ito T, Togame H, Takemoto H, Amano M, Iwasaki N, Minami A, Nishimura SI
Biochimica et biophysica acta 2013年10月
Allying with armored snails: the complete genome of gammaproteobacterial endosymbiont.
Nakagawa S, Shimamura S, Takaki Y, Suzuki Y, Murakami SI, Watanabe T, Fujiyoshi S, Mino S, Sawabe T, Maeda T, Makita H, Nemoto S, Nishimura SI, Watanabe H, Watsuji TO, Takai K
The ISME journal 2013年08月
Identification of novel serum biomarkers of hepatocellular carcinoma using glycomic analysis.
Kamiyama T, Yokoo H, Furukawa J, Kurogochi M, Togashi T, Miura N, Nakanishi K, Kamachi H, Kakisaka T, Tsuruga Y, Fujiyoshi M, Taketomi A, Nishimura S, Todo S
Hepatology (Baltimore, Md.) 57 2314-2325 2013年06月
Attomolar detection of influenza A virus hemagglutinin human H1 and avian H5 using glycan-blotted field effect transistor biosensor.
Hideshima S, Hinou H, Ebihara D, Sato R, Kuroiwa S, Nakanishi T, Nishimura S, Osaka T
Analytical chemistry 85 5641-5644 2013年06月
Novel thiosialosides tethered to metal nanoparticles as potent influenza A virus haemagglutinin blockers.
Feng F, Sakoda Y, Ohyanagi T, Nagahori N, Shibuya H, Okamastu M, Miura N, Kida H, Nishimura S
Antiviral chemistry & chemotherapy 23 59-65 2013年05月
Serum glycan as a prognostic marker in patients with advanced hepatocellular carcinoma treated with sorafenib.
Miyahara K, Nouso K, Miyake Y, Nakamura S, Obi S, Amano M, Hirose K, Nishimura SI, Yamamoto K
Hepatology (Baltimore, Md.) 2013年05月
論文を全て表示する
論文閉じる
Rapid and high-throughput N-glycomic analysis of plant glycoproteins.
Kaneko K, Shiraya T, Mitsui T, Nishimura S
Methods in molecular biology (Clifton, N.J.) 1072 645-653 2014年
Clinical utility of high-throughput glycome analysis in patients with pancreatic cancer.
Nouso K, Amano M, Ito YM, Miyahara K, Morimoto Y, Kato H, Tsutsumi K, Tomoda T, Yamamoto N, Nakamura S, Kobayashi S, Kuwaki K, Hagihara H, Onishi H, Miyake Y, Ikeda F, Shiraha H, Takaki A, Nakahara T, Nishimura S, Yamamoto K
Journal of gastroenterology 48 1171-1179 2013年10月
Serum glycan markers for evaluation of disease activity and prediction of clinical course in patients with ulcerative colitis.
Miyahara K, Nouso K, Saito S, Hiraoka S, Harada K, Takahashi S, Morimoto Y, Kobayashi S, Ikeda F, Miyake Y, Shiraha H, Takaki A, Okada H, Amano M, Hirose K, Nishimura S, Yamamoto K
PloS one 8 e74861 2013年10月
Serum N-glycan alteration associated with renal cell carcinoma detected by high-throughput glycan analysis.
Hatakeyama S, Amano M, Tobisawa Y, Yoneyama T, Tsuchiya N, Habuchi T, Nishimura SI, Ohyama C
The Journal of urology 2013年10月
Discovery of novel differentiation markers in the early stage of chondrogenesis by glycoform-focused reverse proteomics and genomics.
Ishihara T, Kakiya K, Takahashi K, Miwa H, Rokushima M, Yoshinaga T, Tanaka Y, Ito T, Togame H, Takemoto H, Amano M, Iwasaki N, Minami A, Nishimura SI
Biochimica et biophysica acta 2013年10月
Allying with armored snails: the complete genome of gammaproteobacterial endosymbiont.
Nakagawa S, Shimamura S, Takaki Y, Suzuki Y, Murakami SI, Watanabe T, Fujiyoshi S, Mino S, Sawabe T, Maeda T, Makita H, Nemoto S, Nishimura SI, Watanabe H, Watsuji TO, Takai K
The ISME journal 2013年08月
Identification of novel serum biomarkers of hepatocellular carcinoma using glycomic analysis.
Kamiyama T, Yokoo H, Furukawa J, Kurogochi M, Togashi T, Miura N, Nakanishi K, Kamachi H, Kakisaka T, Tsuruga Y, Fujiyoshi M, Taketomi A, Nishimura S, Todo S
Hepatology (Baltimore, Md.) 57 2314-2325 2013年06月
Attomolar detection of influenza A virus hemagglutinin human H1 and avian H5 using glycan-blotted field effect transistor biosensor.
Hideshima S, Hinou H, Ebihara D, Sato R, Kuroiwa S, Nakanishi T, Nishimura S, Osaka T
Analytical chemistry 85 5641-5644 2013年06月
Novel thiosialosides tethered to metal nanoparticles as potent influenza A virus haemagglutinin blockers.
Feng F, Sakoda Y, Ohyanagi T, Nagahori N, Shibuya H, Okamastu M, Miura N, Kida H, Nishimura S
Antiviral chemistry & chemotherapy 23 59-65 2013年05月
Serum glycan as a prognostic marker in patients with advanced hepatocellular carcinoma treated with sorafenib.
Miyahara K, Nouso K, Miyake Y, Nakamura S, Obi S, Amano M, Hirose K, Nishimura SI, Yamamoto K
Hepatology (Baltimore, Md.) 2013年05月
Microwave-assisted solid-phase synthesis of antifreeze glycopeptides.
Izumi R, Matsushita T, Fujitani N, Naruchi K, Shimizu H, Tsuda S, Hinou H, Nishimura S
Chemistry (Weinheim an der Bergstrasse, Germany) 19 3913-3920 2013年03月
Glycoblotting-based high throughput protocol for the structural characterization of hyaluronan degradation products during enzymatic fragmentation.
Furukawa T, Arai M, Garcia-Martin F, Amano M, Hinou H, Nishimura S
Glycoconjugate journal 30 171-182 2013年02月
Fluorescence polarization-based assay using N-glycan-conjugated quantum dots for screening in hemagglutinin blockers for influenza A viruses.
Okamatsu M, Feng F, Ohyanagi T, Nagahori N, Someya K, Sakoda Y, Miura N, Nishimura S, Kida H
Journal of virological methods 187 390-394 2013年02月
Effect of ganglioside GM3 synthase gene knockout on the glycoprotein N-glycan profile of mouse embryonic fibroblast.
Nagahori N, Yamashita T, Amano M, Nishimura S
Chembiochem : a European journal of chemical biology 14 73-82 2013年01月
Macrocyclic mechanism-based inhibitor for neuraminidases.
Kai H, Hinou H, Naruchi K, Matsushita T, Nishimura S
Chemistry (Weinheim an der Bergstrasse, Germany) 19 1364-1372 2013年01月
Site-specific conformational alteration induced by sialylation of MUC1 tandem repeating glycopeptides at an epitope region for the anti-KL-6 monoclonal antibody.
Matsushita T, Ohyabu N, Fujitani N, Naruchi K, Shimizu H, Hinou H, Nishimura S
Biochemistry 52 402-414 2013年01月
Further examination of polysaccharides causing membrane fouling in membrane bioreactors (MBRs): Application of lectin affinity chromatography and MALDI-TOF/MS.
Kimura K, Tanaka I, Nishimura S, Miyoshi R, Miyoshi T, Watanabe Y
Water research 46 5725-5734 2012年11月
Tumour suppressor p16(INK4a) - anoikis-favouring decrease in N/O-glycan/cell surface sialylation by down-regulation of enzymes in sialic acid biosynthesis in tandem in a pancreatic carcinoma model.
Amano M, Eriksson H, Manning JC, Detjen KM, André S, Nishimura S, Lehtiö J, Gabius HJ
The FEBS journal 279 4062-4080 2012年11月
Molecular shuttle between extracellular and cytoplasmic space allows for monitoring of GAG biosynthesis in human articular chondrocytes.
Hoshi H, Shimawaki K, Takegawa Y, Ohyanagi T, Amano M, Hinou H, Nishimura S
Biochimica et biophysica acta 1820 1391-1398 2012年09月
Glycomics for drug discovery: metabolic perturbation in androgen-independent prostate cancer cells induced by unnatural hexosamine mimics.
Nishimura S, Hato M, Hyugaji S, Feng F, Amano M
Angewandte Chemie (International ed. in English) 51 3386-3390 2012年04月
Aglycone-focused randomization of 2-difluoromethylphenyl-type sialoside suicide substrates for neuraminidases.
Kai H, Hinou H, Nishimura S
Bioorganic & medicinal chemistry 20 2739-2746 2012年04月
Strict stereocontrol by 2,4-O-di-tert-butylsilylene group on β-glucuronylations.
Furukawa T, Hinou H, Nishimura S
Organic letters 14 2102-2105 2012年04月
Elucidation of the sugar recognition ability of the lectin domain of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3 by using unnatural glycopeptide substrates.
Yoshimura Y, Nudelman AS, Levery SB, Wandall HH, Bennett EP, Hindsgaul O, Clausen H, Nishimura S
Glycobiology 22 429-438 2012年03月
Phosphorylcholine self-assembled monolayer-coated quantum dots: real-time imaging of live animals by cell surface mimetic glyco-nanoparticles.
Nishimura S
Clinics in laboratory medicine 32 73-87 2012年03月
An efficient protocol for the solid-phase synthesis of glycopeptides under microwave irradiation.
Garcia-Martin F, Hinou H, Matsushita T, Hayakawa S, Nishimura S
Organic & biomolecular chemistry 10 1612-1617 2012年02月
Effects of single genetic damage in carbohydrate-recognizing proteins in mouse serum N-glycan profile revealed by simple glycotyping analysis.
Amano M, Hashimoto R, Nishimura S
Chembiochem : a European journal of chemical biology 13 451-464 2012年02月
Determination of O-glycosylation heterogeneity using a mass-spectrometric method retaining sugar modifications.
Manri N, Takegawa Y, Fujitani N, Kaneko A, Hirabayashi A, Nishimura S, Sakamoto T
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 28 723-727 2012年
Alterations of high-mannose type N-glycosylation in human and mouse osteoarthritis cartilage.
Urita A, Matsuhashi T, Onodera T, Nakagawa H, Hato M, Amano M, Seito N, Minami A, Nishimura S, Iwasaki N
Arthritis and rheumatism 63 3428-3438 2011年11月
Alteration of the N-glycome of bovine milk glycoproteins during early lactation.
Takimori S, Shimaoka H, Furukawa J, Yamashita T, Amano M, Fujitani N, Takegawa Y, Hammarström L, Kacskovics I, Shinohara Y, Nishimura S
The FEBS journal 278 3769-3781 2011年10月
Development of quantitative plasma N-glycoproteomics using label-free 2-D LC-MALDI MS and its applicability for biomarker discovery in hepatocellular carcinoma.
Ishihara T, Fukuda I, Morita A, Takinami Y, Okamoto H, Nishimura S, Numata Y
Journal of proteomics 74 2159-2168 2011年09月
Importance of sialic acid residues illuminated by live animal imaging using phosphorylcholine self-assembled monolayer-coated quantum dots.
Ohyanagi T, Nagahori N, Shimawaki K, Hinou H, Yamashita T, Sasaki A, Jin T, Iwanaga T, Kinjo M, Nishimura S
Journal of the American Chemical Society 133 12507-12517 2011年08月
Biomechanical and histologic evaluation of tissue engineered ligaments using chitosan and hyaluronan hybrid polymer fibers: a rabbit medial collateral ligament reconstruction model.
Irie T, Majima T, Sawaguchi N, Funakoshi T, Nishimura S, Minami A
Journal of biomedical materials research. Part A 97 111-117 2011年05月
Insight into glycan diversity and evolutionary lineage based on comparative Avio-N-glycomics and sialic acid analysis of 88 egg whites of Galloanserae.
Hirose K, Amano M, Hashimoto R, Lee YC, Nishimura S
Biochemistry 50 4757-4774 2011年05月
A strategy for neuraminidase inhibitors using mechanism-based labeling information.
Hinou H, Miyoshi R, Takasu Y, Kai H, Kurogochi M, Arioka S, Gao XD, Miura N, Fujitani N, Omoto S, Yoshinaga T, Fujiwara T, Noshi T, Togame H, Takemoto H, Nishimura S
Chemistry, an Asian journal 6 1048-1056 2011年04月
An efficient approach for the characterization of mucin-type glycopeptides: the effect of O-glycosylation on the conformation of synthetic mucin peptides.
Hashimoto R, Fujitani N, Takegawa Y, Kurogochi M, Matsushita T, Naruchi K, Ohyabu N, Hinou H, Gao XD, Manri N, Satake H, Kaneko A, Sakamoto T, Nishimura S
Chemistry (Weinheim an der Bergstrasse, Germany) 17 2393-2404 2011年02月
Membrane-bound stable glycosyltransferases: highly oriented protein immobilization by a C-terminal cationic amphipathic peptide.
Naruchi K, Nishimura S
Angewandte Chemie (International ed. in English) 50 1328-1331 2011年02月
[Significance of posttranslational modifications uncovered by glycoblotting method and development of large-scale glycomics].
Arnano M, Miura Y, Nishimura S
Seikagaku. The Journal of Japanese Biochemical Society 83 5-12 2011年01月
Toward automated glycan analysis.
Nishimura S
Advances in carbohydrate chemistry and biochemistry 65 219-271 2011年
Glycoblotting-assisted O-glycomics: ammonium carbamate allows for highly efficient o-glycan release from glycoproteins.
Miura Y, Kato K, Takegawa Y, Kurogochi M, Furukawa J, Shinohara Y, Nagahori N, Amano M, Hinou H, Nishimura S
Analytical chemistry 82 10021-10029 2010年12月
Sialic acid-focused quantitative mouse serum glycoproteomics by multiple reaction monitoring assay.
Kurogochi M, Matsushista T, Amano M, Furukawa J, Shinohara Y, Aoshima M, Nishimura S
Molecular & cellular proteomics : MCP 9 2354-2368 2010年11月
Artificial Golgi apparatus: globular protein-like dendrimer facilitates fully automated enzymatic glycan synthesis.
Matsushita T, Nagashima I, Fumoto M, Ohta T, Yamada K, Shimizu H, Hinou H, Naruchi K, Ito T, Kondo H, Nishimura S
Journal of the American Chemical Society 132 16651-16656 2010年11月
Chemical synthesis, folding, and structural insights into O-fucosylated epidermal growth factor-like repeat 12 of mouse Notch-1 receptor.
Hiruma-Shimizu K, Hosoguchi K, Liu Y, Fujitani N, Ohta T, Hinou H, Matsushita T, Shimizu H, Feizi T, Nishimura S
Journal of the American Chemical Society 132 14857-14865 2010年10月
A new class of mechanism-based inhibitors for Trypanosoma cruzi trans-sialidase and their influence on parasite virulence.
Carvalho ST, Sola-Penna M, Oliveira IA, Pita S, Gonçalves AS, Neves BC, Sousa FR, Freire-de-Lima L, Kurogochi M, Hinou H, Nishimura S, Mendonça-Previato L, Previato JO, Todeschini AR
Glycobiology 20 1034-1045 2010年08月
Identification of glycosylated exendin-4 analogue with prolonged blood glucose-lowering activity through glycosylation scanning substitution.
Ueda T, Ito T, Tomita K, Togame H, Fumoto M, Asakura K, Oshima T, Nishimura S, Hanasaki K
Bioorganic & medicinal chemistry letters 20 4631-4634 2010年08月
An efficient approach to the discovery of potent inhibitors against glycosyltransferases.
Hosoguchi K, Maeda T, Furukawa J, Shinohara Y, Hinou H, Sekiguchi M, Togame H, Takemoto H, Kondo H, Nishimura S
Journal of medicinal chemistry 53 5607-5619 2010年08月
Unexpected tolerance of glycosylation by UDP-GalNAc:polypeptide alpha-N-acetylgalactosaminyltransferase revealed by electron capture dissociation mass spectrometry: carbohydrate as potential protective groups.
Yoshimura Y, Matsushita T, Fujitani N, Takegawa Y, Fujihira H, Naruchi K, Gao XD, Manri N, Sakamoto T, Kato K, Hinou H, Nishimura S
Biochemistry 49 5929-5941 2010年07月
Effect of cyclic three-dimensional strain on cell proliferation and collagen synthesis of fibroblast-seeded chitosan-hyaluronan hybrid polymer fiber.
Sawaguchi N, Majima T, Funakoshi T, Shimode K, Harada K, Minami A, Nishimura S
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 15 569-577 2010年07月
Novel trivalent anti-influenza reagent.
Feng F, Miura N, Isoda N, Sakoda Y, Okamatsu M, Kida H, Nishimura S
Bioorganic & medicinal chemistry letters 20 3772-3776 2010年06月
Functional network of glycan-related molecules: glyco-net in glycoconjugate data bank.
Hashimoto R, Hirose K, Sato T, Fukushima N, Miura N, Nishimura S
BMC systems biology 4 91 2010年06月
Threshold in stage-specific embryonic glycotypes uncovered by a full portrait of dynamic N-glycan expression during cell differentiation.
Amano M, Yamaguchi M, Takegawa Y, Yamashita T, Terashima M, Furukawa J, Miura Y, Shinohara Y, Iwasaki N, Minami A, Nishimura S
Molecular & cellular proteomics : MCP 9 523-537 2010年03月
Carbohydrate moieties contribute significantly to the physicochemical properties of french bean 7s globulin phaseolin.
Kimura A, Tandang-Silvas MR, Fukuda T, Cabanos C, Takegawa Y, Amano M, Nishimura S, Matsumura Y, Utsumi S, Maruyama N
Journal of agricultural and food chemistry 58 2923-2930 2010年03月
Highly oriented recombinant glycosyltransferases: site-specific immobilization of unstable membrane proteins by using Staphylococcus aureus sortase A.
Ito T, Sadamoto R, Naruchi K, Togame H, Takemoto H, Kondo H, Nishimura S
Biochemistry 49 2604-2614 2010年03月
Potent inhibitor scaffold against Trypanosoma cruzi trans-sialidase.
Arioka S, Sakagami M, Uematsu R, Yamaguchi H, Togame H, Takemoto H, Hinou H, Nishimura S
Bioorganic & medicinal chemistry 18 1633-1640 2010年02月
Large-scale glycomics for discovering cancer-associated N-glycans by integrating glycoblotting and mass spectrometry.
Amano M, Nishimura S
Methods in enzymology 478 109-125 2010年
Novel synthesis of functional mucin glycopeptides containing both N- and O-glycans.
Matsushita T, Nishimura S
Methods in enzymology 478 485-502 2010年
An essential epitope of anti-MUC1 monoclonal antibody KL-6 revealed by focused glycopeptide library.
Ohyabu N, Hinou H, Matsushita T, Izumi R, Shimizu H, Kawamoto K, Numata Y, Togame H, Takemoto H, Kondo H, Nishimura S
Journal of the American Chemical Society 131 17102-17109 2009年12月
Microwave effect for glycosylation promoted by solid super acid in supercritical carbon dioxide.
Hinou H, Saito N, Ogawa M, Maeda T, Nishimura S
International journal of molecular sciences 10 5285-5295 2009年12月
Functional neoglycopeptides: synthesis and characterization of a new class of MUC1 glycoprotein models having core 2-based O-glycan and complex-type N-glycan chains.
Matsushita T, Sadamoto R, Ohyabu N, Nakata H, Fumoto M, Fujitani N, Takegawa Y, Sakamoto T, Kurogochi M, Hinou H, Shimizu H, Ito T, Naruchi K, Togame H, Takemoto H, Kondo H, Nishimura S
Biochemistry 48 11117-11133 2009年11月
Chemoenzymatic synthesis of glycosylated glucagon-like peptide 1: effect of glycosylation on proteolytic resistance and in vivo blood glucose-lowering activity.
Ueda T, Tomita K, Notsu Y, Ito T, Fumoto M, Takakura T, Nagatome H, Takimoto A, Mihara S, Togame H, Kawamoto K, Iwasaki T, Asakura K, Oshima T, Hanasaki K, Nishimura S, Kondo H
Journal of the American Chemical Society 131 6237-6245 2009年05月
One-pot synthesis of cyclic antifreeze glycopeptides.
Hachisu M, Hinou H, Takamichi M, Tsuda S, Koshida S, Nishimura S
Chemical communications (Cambridge, England)  1641-1643 2009年04月
Glycosylation specific for adhesion molecules in epidermis and its receptor revealed by glycoform-focused reverse genomics.
Uematsu R, Shinohara Y, Nakagawa H, Kurogochi M, Furukawa J, Miura Y, Akiyama M, Shimizu H, Nishimura S
Molecular & cellular proteomics : MCP 8 232-244 2009年02月
Structural and functional glycosphingolipidomics by glycoblotting with an aminooxy-functionalized gold nanoparticle.
Nagahori N, Abe M, Nishimura S
Biochemistry 48 583-594 2009年01月
MALDI-TOF mass-spectrometry-based versatile method for the characterization of protein kinases.
Kondo N, Nishimura S
Chemistry (Weinheim an der Bergstrasse, Germany) 15 1413-1421 2009年
Mechanism-based probing, characterization, and inhibitor design of glycosidases and glycosyltransferases.
Hinou H, Nishimura S
Current topics in medicinal chemistry 9 106-116 2009年
Interaction between the C termini of Alg13 and Alg14 mediates formation of the active UDP-N-acetylglucosamine transferase complex.
Gao XD, Moriyama S, Miura N, Dean N, Nishimura S
The Journal of biological chemistry 283 32534-32541 2008年11月
Crucial role of aspartic acid at position 265 in the CH2 domain for murine IgG2a and IgG2b Fc-associated effector functions.
Baudino L, Shinohara Y, Nimmerjahn F, Furukawa J, Nakata M, Martínez-Soria E, Petry F, Ravetch JV, Nishimura S, Izui S
Journal of immunology (Baltimore, Md. : 1950) 181 6664-6669 2008年11月
A novel beta-defensin structure: a potential strategy of big defensin for overcoming resistance by Gram-positive bacteria.
Kouno T, Fujitani N, Mizuguchi M, Osaki T, Nishimura S, Kawabata S, Aizawa T, Demura M, Nitta K, Kawano K
Biochemistry 47 10611-10619 2008年10月
[Large-scale glycomics reveals dynamic nature of proteome].
Nakahara T, Nishimura S
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 53 1708-1715 2008年09月
Impact of a three amino acid deletion in the CH2 domain of murine IgG1 on Fc-associated effector functions.
Baudino L, Nimmerjahn F, Shinohara Y, Furukawa J, Petry F, Verbeek JS, Nishimura S, Ravetch JV, Izui S
Journal of immunology (Baltimore, Md. : 1950) 181 4107-4112 2008年09月
Two-dimensional hydrophilic interaction chromatography coupling anion-exchange and hydrophilic interaction columns for separation of 2-pyridylamino derivatives of neutral and sialylated N-glycans.
Deguchi K, Keira T, Yamada K, Ito H, Takegawa Y, Nakagawa H, Nishimura S
Journal of chromatography. A 1189 169-174 2008年05月
Glycosylation status of haptoglobin in sera of patients with prostate cancer vs. benign prostate disease or normal subjects.
Fujimura T, Shinohara Y, Tissot B, Pang PC, Kurogochi M, Saito S, Arai Y, Sadilek M, Murayama K, Dell A, Nishimura S, Hakomori SI
International journal of cancer. Journal international du cancer 122 39-49 2008年01月
Glycoconjugate Data Bank: Structures--an annotated glycan structure database and N-glycan primary structure verification service.
Nakahara T, Hashimoto R, Nakagawa H, Monde K, Miura N, Nishimura S
Nucleic acids research 36 D368-71 2008年01月
FRET-based direct and continuous monitoring of human fucosyltransferases activity: an efficient synthesis of versatile GDP-L-fucose derivatives from abundant D-galactose.
Maeda T, Nishimura S
Chemistry (Weinheim an der Bergstrasse, Germany) 14 478-487 2008年
Bacterial surface engineering utilizing glucosamine phosphate derivatives as cell wall precursor surrogates.
Sadamoto R, Matsubayashi T, Shimizu M, Ueda T, Koshida S, Koda T, Nishimura S
Chemistry (Weinheim an der Bergstrasse, Germany) 14 10192-10195 2008年
Analysis of N-glycan in serum glycoproteins from db/db mice and humans with type 2 diabetes.
Itoh N, Sakaue S, Nakagawa H, Kurogochi M, Ohira H, Deguchi K, Nishimura S, Nishimura M
American journal of physiology. Endocrinology and metabolism 293 E1069-77 2007年10月
Structural transition of a 15 amino acid residue peptide induced by GM1.
Fujitani N, Shimizu H, Matsubara T, Ohta T, Komata Y, Miura N, Sato T, Nishimura S
Carbohydrate research 342 1895-1903 2007年09月
High-performance liquid chromatography with ultraviolet detection for real-time therapeutic drug monitoring of meropenem in plasma.
Ikeda K, Ikawa K, Morikawa N, Miki M, Nishimura S, Kobayashi M
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 856 371-375 2007年09月
Swainsonine reduces 5-fluorouracil tolerance in the multistage resistance of colorectal cancer cell lines.
Hamaguchi J, Nakagawa H, Takahashi M, Kudo T, Kamiyama N, Sun B, Oshima T, Sato Y, Deguchi K, Todo S, Nishimura S
Molecular cancer 6 58 2007年09月
Quantitative glycomics of human whole serum glycoproteins based on the standardized protocol for liberating N-glycans.
Kita Y, Miura Y, Furukawa J, Nakano M, Shinohara Y, Ohno M, Takimoto A, Nishimura S
Molecular & cellular proteomics : MCP 6 1437-1445 2007年08月
Tumor suppressor p16INK4a--modulator of glycomic profile and galectin-1 expression to increase susceptibility to carbohydrate-dependent induction of anoikis in pancreatic carcinoma cells.
André S, Sanchez-Ruderisch H, Nakagawa H, Buchholz M, Kopitz J, Forberich P, Kemmner W, Böck C, Deguchi K, Detjen KM, Wiedenmann B, von Knebel Doeberitz M, Gress TM, Nishimura S, Rosewicz S, Gabius HJ
The FEBS journal 274 3233-3256 2007年07月
Effect of pore size on in vitro cartilage formation using chitosan-based hyaluronic acid hybrid polymer fibers.
Yamane S, Iwasaki N, Kasahara Y, Harada K, Majima T, Monde K, Nishimura S, Minami A
Journal of biomedical materials research. Part A 81 586-593 2007年06月
Cell growth arrest by sialic acid clusters in ganglioside GM3 mimetic polymers.
Uemura S, Feng F, Kume M, Yamada K, Kabayama K, Nishimura S, Igarashi Y, Inokuchi J
Glycobiology 17 568-577 2007年06月
Detection of altered N-glycan profiles in whole serum from rheumatoid arthritis patients.
Nakagawa H, Hato M, Takegawa Y, Deguchi K, Ito H, Takahata M, Iwasaki N, Minami A, Nishimura S
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 853 133-137 2007年06月
N-glycan alterations are associated with drug resistance in human hepatocellular carcinoma.
Kudo T, Nakagawa H, Takahashi M, Hamaguchi J, Kamiyama N, Yokoo H, Nakanishi K, Nakagawa T, Kamiyama T, Deguchi K, Nishimura S, Todo S
Molecular cancer 6 32 2007年05月
Molecular basis of guanine nucleotide dissociation inhibitor activity of human neuroglobin by chemical cross-linking and mass spectrometry.
Kitatsuji C, Kurogochi M, Nishimura S, Ishimori K, Wakasugi K
Journal of molecular biology 368 150-160 2007年04月
The solution structure of horseshoe crab antimicrobial peptide tachystatin B with an inhibitory cystine-knot motif.
Fujitani N, Kouno T, Nakahara T, Takaya K, Osaki T, Kawabata S, Mizuguchi M, Aizawa T, Demura M, Nishimura S, Kawano K
Journal of peptide science : an official publication of the European Peptide Society 13 269-279 2007年04月
A review of 331 rhabdomyosarcoma cases in patients treated between 1991 and 2002 in Japan.
Hosoi H, Teramukai S, Matsumoto Y, Tsuchiya K, Iehara T, Hara J, Mitsui T, Kaneko M, Hatae Y, Hayashi Y, Mabuchi O, Adachi N, Morikawa Y, Nishimura S, Kumagai M, Takamatsu H, Sawada T, Sugimoto T
International journal of clinical oncology 12 137-145 2007年04月
AsialoGM1+CD8+ central memory-type T cells in unimmunized mice as novel immunomodulator of IFN-gamma-dependent type 1 immunity.
Kosaka A, Wakita D, Matsubara N, Togashi Y, Nishimura S, Kitamura H, Nishimura T
International immunology 19 249-256 2007年03月
[Complications in the central nervous system during chemotherapy for childhood acute lymphoblastic leukemia: JACLS ALL-02 study].
Umeda K, Yoshida M, Suzuki N, Endo M, Sato A, Hori H, Isogai M, Matsumoto K, Hara JI, Hasegawa D, Hashii Y, Chayama K, Miyaji R, Nishimura S, Tanizawa A, Uami I, Horibe K, Wakazono Y, Yagi K
[Rinsho ketsueki] The Japanese journal of clinical hematology 48 204-211 2007年03月
N-linked neutral oligosaccharides in the stratum corneum of normal and ichthyotic skin.
Ito H, Akiyama M, Nakagawa H, Uematsu R, Deguchi K, McMillan JR, Nishimura S, Shimizu H
Archives of dermatological research 298 403-407 2007年01月
Structural assignment of disialylated biantennary N-glycan isomers derivatized with 2-aminopyridine using negative-ion multistage tandem mass spectral matching.
Ito H, Yamada K, Deguchi K, Nakagawa H, Nishimura S
Rapid communications in mass spectrometry : RCM 21 212-218 2007年
One-pot solid-phase glycoblotting and probing by transoximization for high-throughput glycomics and glycoproteomics.
Shimaoka H, Kuramoto H, Furukawa J, Miura Y, Kurogochi M, Kita Y, Hinou H, Shinohara Y, Nishimura S
Chemistry (Weinheim an der Bergstrasse, Germany) 13 1664-1673 2007年
Structural analysis of O-glycopeptides employing negative- and positive-ion multi-stage mass spectra obtained by collision-induced and electron-capture dissociations in linear ion trap time-of-flight mass spectrometry.
Deguchi K, Ito H, Baba T, Hirabayashi A, Nakagawa H, Fumoto M, Hinou H, Nishimura S
Rapid communications in mass spectrometry : RCM 21 691-698 2007年
Highly efficient and versatile synthesis of proteoglycan core structures from 1,6-anhydro-beta-lactose as a key starting material.
Shimawaki K, Fujisawa Y, Sato F, Fujitani N, Kurogochi M, Hoshi H, Hinou H, Nishimura S
Angewandte Chemie (International ed. in English) 46 3074-3079 2007年
Rapid and simple solid-phase esterification of sialic acid residues for quantitative glycomics by mass spectrometry.
Miura Y, Shinohara Y, Furukawa J, Nagahori N, Nishimura S
Chemistry (Weinheim an der Bergstrasse, Germany) 13 4797-4804 2007年
Reverse glycoblotting allows rapid-enrichment glycoproteomics of biopharmaceuticals and disease-related biomarkers.
Kurogochi M, Amano M, Fumoto M, Takimoto A, Kondo H, Nishimura S
Angewandte Chemie (International ed. in English) 46 8808-8813 2007年
Computational design and experimental evaluation of glycosyltransferase mutants: engineering of a blood type B galactosyltransferase with enhanced glucosyltransferase activity.
Nakahara T, Hindsgaul O, Palcic MM, Nishimura S
Protein engineering, design & selection : PEDS 19 571-578 2006年12月
Construction and structural characterization of versatile lactosaminoglycan-related compound library for the synthesis of complex glycopeptides and glycosphingolipids.
Naruchi K, Hamamoto T, Kurogochi M, Hinou H, Shimizu H, Matsushita T, Fujitani N, Kondo H, Nishimura S
The Journal of organic chemistry 71 9609-9621 2006年12月
Unusual N-glycan structures in alpha-mannosidase II/IIx double null embryos identified by a systematic glycomics approach based on two-dimensional LC mapping and matrix-dependent selective fragmentation method in MALDI-TOF/TOF mass spectrometry.
Hato M, Nakagawa H, Kurogochi M, Akama TO, Marth JD, Fukuda MN, Nishimura S
Molecular & cellular proteomics : MCP 5 2146-2157 2006年11月
Interleukin-12-responding asialoGM1+CD8+ central memory-type T cells as precursor cells for interferon-gamma-producing killer T cells.
Kosaka A, Lee U, Wakita D, Matsubara N, Togashi Y, Nishimura S, Kitamura H, Nishimura T
Cancer science 97 1236-1241 2006年11月
Specific cell behavior of human fibroblast onto carbohydrate surface detected by glycoblotting films.
Onodera T, Niikura K, Iwasaki N, Nagahori N, Shimaoka H, Kamitani R, Majima T, Minami A, Nishimura S
Biomacromolecules 7 2949-2955 2006年11月
Simple separation of isomeric sialylated N-glycopeptides by a zwitterionic type of hydrophilic interaction chromatography.
Takegawa Y, Deguchi K, Ito H, Keira T, Nakagawa H, Nishimura S
Journal of separation science 29 2533-2540 2006年11月
Direct and efficient monitoring of glycosyltransferase reactions on gold colloidal nanoparticles by using mass spectrometry.
Nagahori N, Nishimura S
Chemistry (Weinheim an der Bergstrasse, Germany) 12 6478-6485 2006年08月
Glycosidation promoted by a reusable solid superacid in supercritical carbon dioxide.
Li XB, Ogawa M, Monden T, Maeda T, Yamashita E, Naka M, Matsuda M, Hinou H, Nishimura S
Angewandte Chemie (International ed. in English) 45 5652-5655 2006年08月
Essential and mutually compensatory roles of {alpha}-mannosidase II and {alpha}-mannosidase IIx in N-glycan processing in vivo in mice.
Akama TO, Nakagawa H, Wong NK, Sutton-Smith M, Dell A, Morris HR, Nakayama J, Nishimura S, Pai A, Moremen KW, Marth JD, Fukuda MN
Proceedings of the National Academy of Sciences of the United States of America 103 8983-8988 2006年06月
[X-linked hypogammaglobulinemia with growth hormone deficiency].
Okada S, Miyagawa S, Nishimura S, Kobayashi M, Nishi Y
Nihon rinsho. Japanese journal of clinical medicine Suppl 1 67-69 2006年05月
Separation of isomeric 2-aminopyridine derivatized N-glycans and N-glycopeptides of human serum immunoglobulin G by using a zwitterionic type of hydrophilic-interaction chromatography.
Takegawa Y, Deguchi K, Keira T, Ito H, Nakagawa H, Nishimura S
Journal of chromatography. A 1113 177-181 2006年04月
Construction of highly glycosylated mucin-type glycopeptides based on microwave-assisted solid-phase syntheses and enzymatic modifications.
Matsushita T, Hinou H, Fumoto M, Kurogochi M, Fujitani N, Shimizu H, Nishimura S
The Journal of organic chemistry 71 3051-3063 2006年04月
N-acetylglucosaminyltransferase V and beta1-6 branching N-linked oligosaccharides are associated with good prognosis of patients with bladder cancer.
Ishimura H, Takahashi T, Nakagawa H, Nishimura S, Arai Y, Horikawa Y, Habuchi T, Miyoshi E, Kyan A, Hagisawa S, Ohyama C
Clinical cancer research : an official journal of the American Association for Cancer Research 12 2506-2511 2006年04月
Effects of synthetic antifreeze glycoprotein analogue on islet cell survival and function during cryopreservation.
Matsumoto S, Matsusita M, Morita T, Kamachi H, Tsukiyama S, Furukawa Y, Koshida S, Tachibana Y, Nishimura S, Todo S
Cryobiology 52 90-98 2006年02月
Structural assignment of isomeric 2-aminopyridine-derivatized monosialylated biantennary N-linked oligosaccharides using negative-ion multistage tandem mass spectral matching.
Deguchi K, Takegawa Y, Ito H, Miura N, Yoshioka S, Nagai S, Nakagawa H, Nishimura S
Rapid communications in mass spectrometry : RCM 20 412-418 2006年
Complementary structural information of positive- and negative-ion MSn spectra of glycopeptides with neutral and sialylated N-glycans.
Deguchi K, Ito H, Takegawa Y, Shinji N, Nakagawa H, Nishimura S
Rapid communications in mass spectrometry : RCM 20 741-746 2006年
Direct structural assignment of neutral and sialylated N-glycans of glycopeptides using collision-induced dissociation MSn spectral matching.
Ito H, Takegawa Y, Deguchi K, Nagai S, Nakagawa H, Shinohara Y, Nishimura S
Rapid communications in mass spectrometry : RCM 20 3557-3565 2006年
Mechanism-based inhibitors to probe transitional states of glycoside hydrolases.
Hinou H, Kurogochi M, Nishimura S
Methods in enzymology 415 202-212 2006年
High throughput quantitative glycomics and glycoform-focused proteomics of murine dermis and epidermis.
Uematsu R, Furukawa J, Nakagawa H, Shinohara Y, Deguchi K, Monde K, Nishimura S
Molecular & cellular proteomics : MCP 4 1977-1989 2005年12月
Molecular design of glycoprotein mimetics: glycoblotting by engineered proteins with an oxylamino-functionalized amino acid residue.
Matsubara N, Oiwa K, Hohsaka T, Sadamoto R, Niikura K, Fukuhara N, Takimoto A, Kondo H, Nishimura S
Chemistry (Weinheim an der Bergstrasse, Germany) 11 6974-6981 2005年11月
Chitosan-RGDSGGC conjugate as a scaffold material for musculoskeletal tissue engineering.
Masuko T, Iwasaki N, Yamane S, Funakoshi T, Majima T, Minami A, Ohsuga N, Ohta T, Nishimura S
Biomaterials 26 5339-5347 2005年09月
Novel chitosan-based hyaluronan hybrid polymer fibers as a scaffold in ligament tissue engineering.
Funakoshi T, Majima T, Iwasaki N, Yamane S, Masuko T, Minami A, Harada K, Tamura H, Tokura S, Nishimura S
Journal of biomedical materials research. Part A 74 338-346 2005年09月
Characterization of Vibrio cholerae neuraminidase by a novel mechanism-based fluorescent labeling reagent.
Hinou H, Kurogochi M, Shimizu H, Nishimura S
Biochemistry 44 11669-11675 2005年09月
Structural analysis of an N-glycan with "beta1-4 bisecting branch" from human serum IgG by negative-ion MSn spectral matching and exoglycosidase digestion.
Takegawa Y, Deguchi K, Nakagawa H, Nishimura S
Analytical chemistry 77 6062-6068 2005年09月
Rational design, synthesis, and characterization of novel inhibitors for human beta1,4-galactosyltransferase.
Takaya K, Nagahori N, Kurogochi M, Furuike T, Miura N, Monde K, Lee YC, Nishimura S
Journal of medicinal chemistry 48 6054-6065 2005年09月
Application of tissue engineering techniques for rotator cuff regeneration using a chitosan-based hyaluronan hybrid fiber scaffold.
Funakoshi T, Majima T, Iwasaki N, Suenaga N, Sawaguchi N, Shimode K, Minami A, Harada K, Nishimura S
The American journal of sports medicine 33 1193-1201 2005年08月
Combinatorial synthesis of MUC1 glycopeptides: polymer blotting facilitates chemical and enzymatic synthesis of highly complicated mucin glycopeptides.
Fumoto M, Hinou H, Ohta T, Ito T, Yamada K, Takimoto A, Kondo H, Shimizu H, Inazu T, Nakahara Y, Nishimura S
Journal of the American Chemical Society 127 11804-11818 2005年08月
Versatile glycoblotting nanoparticles for high-throughput protein glycomics.
Niikura K, Kamitani R, Kurogochi M, Uematsu R, Shinohara Y, Nakagawa H, Deguchi K, Monde K, Kondo H, Nishimura S
Chemistry (Weinheim an der Bergstrasse, Germany) 11 3825-3834 2005年06月
Nanometer-scale ordering in cast films of columnar metallomesogen as revealed by STM observations.
Kakegawa N, Hoshino N, Matsuoka Y, Wakabayashi N, Nishimura S, Yamagishi A
Chemical communications (Cambridge, England)  2375-2377 2005年05月
A case of adolescent primary adrenal natural killer cell lymphoma.
Mizoguchi Y, Nakamura K, Miyagawa S, Nishimura S, Arihiro K, Kobayashi M
International journal of hematology 81 330-334 2005年05月
Alginate and chitosan polyion complex hybrid fibers for scaffolds in ligament and tendon tissue engineering.
Majima T, Funakosi T, Iwasaki N, Yamane ST, Harada K, Nonaka S, Minami A, Nishimura S
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 10 302-307 2005年05月
Carbohydrate analysis by a phenol-sulfuric acid method in microplate format.
Masuko T, Minami A, Iwasaki N, Majima T, Nishimura S, Lee YC
Analytical biochemistry 339 69-72 2005年04月
Molecular transporter between polymer platforms: highly efficient chemoenzymatic glycopeptide synthesis by the combined use of solid-phase and water-soluble polymer supports.
Fumoto M, Hinou H, Matsushita T, Kurogochi M, Ohta T, Ito T, Yamada K, Takimoto A, Kondo H, Inazu T, Nishimura S
Angewandte Chemie (International ed. in English) 44 2534-2537 2005年04月
Simultaneous analysis of 2-aminopyridine-derivatized neutral and sialylated oligosaccharides from human serum in the negative-ion mode by sonic spray ionization ion trap mass spectrometry.
Takegawa Y, Deguchi K, Ito S, Yoshioka S, Nakagawa H, Nishimura S
Analytical chemistry 77 2097-2106 2005年04月
Rapid microwave-assisted solid-phase glycopeptide synthesis.
Matsushita T, Hinou H, Kurogochi M, Shimizu H, Nishimura S
Organic letters 7 877-880 2005年03月
Thiolation of chitosan. Attachment of proteins via thioether formation.
Masuko T, Minami A, Iwasaki N, Majima T, Nishimura S, Lee YC
Biomacromolecules 6 880-884 2005年03月
Feasibility of chitosan-based hyaluronic acid hybrid biomaterial for a novel scaffold in cartilage tissue engineering.
Yamane S, Iwasaki N, Majima T, Funakoshi T, Masuko T, Harada K, Minami A, Monde K, Nishimura S
Biomaterials 26 611-619 2005年02月
Direct observation of sugar-protein, sugar-sugar, and sugar-water complexes by cold-spray ionization time-of-flight mass spectrometry.
Nishimura S, Nagahori N, Takaya K, Tachibana Y, Miura N, Monde K
Angewandte Chemie (International ed. in English) 44 571-575 2005年01月
Structural assignment of isomeric 2-aminopyridine-derivatized oligosaccharides using negative-ion MSn spectral matching.
Takegawa Y, Deguchi K, Ito S, Yoshioka S, Nakagawa H, Nishimura S
Rapid communications in mass spectrometry : RCM 19 937-946 2005年
Characteristic pH and electrolyte concentration dependences of 2-aminopyridine-derivatized oligosaccharides (N-glycans) in sonic-spray ionization mass spectrometry.
Deguchi K, Takegawa Y, Hirabayashi A, Nakagawa H, Nishimura S
Rapid communications in mass spectrometry : RCM 19 2325-2330 2005年
Direct N-glycan profiling in the presence of tryptic peptides on MALDI-TOF by controlled ion enhancement and suppression upon glycan-selective derivatization.
Shinohara Y, Furukawa J, Niikura K, Miura N, Nishimura S
Analytical chemistry 76 6989-6997 2004年12月
Assignment and quantification of 2-aminopyridine derivatized oligosaccharide isomers coeluted on reversed-phase HPLC/MS by MSn spectral library.
Takegawa Y, Deguchi K, Ito S, Yoshioka S, Sano A, Yoshinari K, Kobayashi K, Nakagawa H, Monde K, Nishimura S
Analytical chemistry 76 7294-7303 2004年12月
High-throughput protein glycomics: combined use of chemoselective glycoblotting and MALDI-TOF/TOF mass spectrometry.
Nishimura S, Niikura K, Kurogochi M, Matsushita T, Fumoto M, Hinou H, Kamitani R, Nakagawa H, Deguchi K, Miura N, Monde K, Kondo H
Angewandte Chemie (International ed. in English) 44 91-96 2004年12月
Glycoinsulins: dendritic sialyloligosaccharide-displaying insulins showing a prolonged blood-sugar-lowering activity.
Sato M, Furuike T, Sadamoto R, Fujitani N, Nakahara T, Niikura K, Monde K, Kondo H, Nishimura S
Journal of the American Chemical Society 126 14013-14022 2004年11月
Mechanism-based fluorescent labeling of beta-galactosidases. An efficient method in proteomics for glycoside hydrolases.
Kurogochi M, Nishimura S, Lee YC
The Journal of biological chemistry 279 44704-44712 2004年10月
Structural characterization of N-glycopeptides by matrix-dependent selective fragmentation of MALDI-TOF/TOF tandem mass spectrometry.
Kurogochi M, Nishimura S
Analytical chemistry 76 6097-6101 2004年10月
Vibrational circular dichroism: chiroptical analysis of biomolecules.
Taniguchi T, Miura N, Nishimura S, Monde K
Molecular nutrition & food research 48 246-254 2004年09月
Specific band observed in VCD predicts the anomeric configuration of carbohydrates.
Monde K, Taniguchi T, Miura N, Nishimura S
Journal of the American Chemical Society 126 9496-9497 2004年08月
Post-translational modifications on proteins: facile and efficient procedure for the identification of O-glycosylation sites by MALDI-LIFT-TOF/TOF mass spectrometry.
Kurogochi M, Matsushita T, Nishimura S
Angewandte Chemie (International ed. in English) 43 4071-4075 2004年08月
Chemo-enzymatic synthesis of fluorinated 2-N-acetamidosugar nucleotides using UDP-GlcNAc pyrophosphorylase.
Feng F, Okuyama K, Niikura K, Ohta T, Sadamoto R, Monde K, Noguchi T, Nishimura S
Organic & biomolecular chemistry 2 1617-1623 2004年06月
Feasibility of polysaccharide hybrid materials for scaffolds in cartilage tissue engineering: evaluation of chondrocyte adhesion to polyion complex fibers prepared from alginate and chitosan.
Iwasaki N, Yamane ST, Majima T, Kasahara Y, Minami A, Harada K, Nonaka S, Maekawa N, Tamura H, Tokura S, Shiono M, Monde K, Nishimura S
Biomacromolecules 5 828-833 2004年05月
Synthesis of 4-fluorinated UDP-MurNAc pentapeptide as an inhibitor of bacterial growth.
Ueda T, Feng F, Sadamoto R, Niikura K, Monde K, Nishimura S
Organic letters 6 1753-1756 2004年05月
Azasugar-based MMP/ADAM inhibitors as antipsoriatic agents.
Moriyama H, Tsukida T, Inoue Y, Yokota K, Yoshino K, Kondo H, Miura N, Nishimura S
Journal of medicinal chemistry 47 1930-1938 2004年04月
A practical synthesis of amphiphilic cyclodextrins fully substituted with sugar residues on the primary face.
Sallas F, Niikura K, Nishimura S
Chemical communications (Cambridge, England)  596-597 2004年03月
Synthesis and biological activity of selective azasugar-based TACE inhibitors.
Tsukida T, Moriyama H, Inoue Y, Kondo H, Yoshino K, Nishimura S
Bioorganic & medicinal chemistry letters 14 1569-1572 2004年03月
Site-specific introduction of sialic acid into insulin.
Sato M, Sadamoto R, Niikura K, Monde K, Kondo H, Nishimura S
Angewandte Chemie (International ed. in English) 43 1516-1520 2004年03月
Control of bacteria adhesion by cell-wall engineering.
Sadamoto R, Niikura K, Ueda T, Monde K, Fukuhara N, Nishimura S
Journal of the American Chemical Society 126 3755-3761 2004年03月
IFN-gamma-induced SOCS-1 regulates STAT6-dependent eotaxin production triggered by IL-4 and TNF-alpha.
Sato T, Saito R, Jinushi T, Tsuji T, Matsuzaki J, Koda T, Nishimura Si, Takeshima H, Nishimura T
Biochemical and biophysical research communications 314 468-475 2004年02月
Antifreeze glycoproteins: elucidation of the structural motifs that are essential for antifreeze activity.
Tachibana Y, Fletcher GL, Fujitani N, Tsuda S, Monde K, Nishimura S
Angewandte Chemie (International ed. in English) 43 856-862 2004年02月
An engineered hyaluronan synthase: characterization for recombinant human hyaluronan synthase 2 Escherichia coli.
Hoshi H, Nakagawa H, Nishiguchi S, Iwata K, Niikura K, Monde K, Nishimura S
The Journal of biological chemistry 279 2341-2349 2004年01月
Persubstituted cyclodextrin-based glycoclusters as inhibitors of protein-carbohydrate recognition using purified plant and mammalian lectins and wild-type and lectin-gene-transfected tumor cells as targets.
André S, Kaltner H, Furuike T, Nishimura S, Gabius HJ
Bioconjugate chemistry 15 87-98 2004年01月
Structural assignment of isomeric 2-aminopyridine-derivatized oligosaccharides using MSn spectral matching.
Takegawa Y, Ito S, Yoshioka S, Deguchi K, Nakagawa H, Monde K, Nishimura S
Rapid communications in mass spectrometry : RCM 18 385-391 2004年
Glycotentacles: synthesis of cyclic glycopeptides, toward a tailored blocker of influenza virus hemagglutinin.
Ohta T, Miura N, Fujitani N, Nakajima F, Niikura K, Sadamoto R, Guo CT, Suzuki T, Suzuki Y, Monde K, Nishimura S
Angewandte Chemie (International ed. in English) 42 5186-5189 2003年11月
Functional expression of the TrkC gene, encoding a high affinity receptor for NT-3, in antigen-specific T helper type 2 (Th2) cells.
Sekimoto M, Tsuji T, Matsuzaki J, Chamoto K, Koda T, Nemoto K, Degawa M, Nishimura S, Nishimura T
Immunology letters 88 221-226 2003年09月
Structure--activity relationships of azasugar-based MMP/ADAM inhibitors.
Moriyama H, Tsukida T, Inoue Y, Kondo H, Yoshino K, Nishimura S
Bioorganic & medicinal chemistry letters 13 2737-2740 2003年08月
Design, synthesis and evaluation of novel azasugar-based MMP/ADAM inhibitors.
Moriyama H, Tsukida T, Inoue Y, Kondo H, Yoshino K, Nishimura S
Bioorganic & medicinal chemistry letters 13 2741-2744 2003年08月
Design, synthesis, and evaluation of beta-galactosylceramide mimics promoting beta-glucocerebrosidase activity in keratinocytes.
Fukunaga K, Yoshida M, Nakajima F, Uematsu R, Hara M, Inoue S, Kondo H, Nishimura S
Bioorganic & medicinal chemistry letters 13 813-815 2003年03月
Detection of genes with tissue-specific expression patterns using Akaike's information criterion procedure.
Kadota K, Nishimura S, Bono H, Nakamura S, Hayashizaki Y, Okazaki Y, Takahashi K
Physiological genomics 12 251-259 2003年02月
Pharmacokinetics of etoposide with intravenous drug administration in children and adolescents.
Kato Y, Nishimura S, Sakura N, Ueda K
Pediatrics international : official journal of the Japan Pediatric Society 45 74-79 2003年02月
Determination of etoposide serum concentrations in small pediatric samples by an improved method of reversed-phase high-performance liquid chromatography.
Kato Y, Mawatari H, Nishimura S, Sakura N, Ueda K
Acta medica Okayama 57 21-24 2003年02月
Structure determination and conformational change induced by tyrosine phosphorylation of the N-terminal domain of the alpha-chain of pig gastric H+/K+-ATPase.
Fujitani N, Kanagawa M, Aizawa T, Ohkubo T, Kaya S, Demura M, Kawano K, Nishimura S, Taniguchi K, Nitta K
Biochemical and biophysical research communications 300 223-229 2003年01月
Cell wall engineering of living bacteria through biosynthesis.
Sadamoto R, Niikura K, Monde K, Nishimura S
Methods in enzymology 362 273-286 2003年
Risk-directed treatment of infant acute lymphoblastic leukaemia based on early assessment of MLL gene status: results of the Japan Infant Leukaemia Study (MLL96).
Isoyama K, Eguchi M, Hibi S, Kinukawa N, Ohkawa H, Kawasaki H, Kosaka Y, Oda T, Oda M, Okamura T, Nishimura S, Hayashi Y, Mori T, Imaizumi M, Mizutani S, Tsukimoto I, Kamada N, Ishii E
British journal of haematology 118 999-1010 2002年09月
Inhibition of adhesion of type 1 fimbriated Escherichia coli to highly mannosylated ligands.
Nagahori N, Lee RT, Nishimura S, Pagé D, Roy R, Lee YC
Chembiochem : a European journal of chemical biology 3 836-844 2002年09月
Cell-wall engineering of living bacteria.
Sadamoto R, Niikura K, Sears PS, Liu H, Wong CH, Suksomcheep A, Tomita F, Monde K, Nishimura S
Journal of the American Chemical Society 124 9018-9019 2002年08月
Low plasma levels of hemostatic proteins during the induction phase in children with acute lymphoblastic leukemia: A retrospective study by the JACLS. Japan Association of Childhood Leukemia Study.
Hongo T, Okada S, Ohzeki T, Ohta H, Nishimura S, Hamamoto K, Yagi K, Misu H, Eguchi N, Suzuki N, Horibe K, Ueda K
Pediatrics international : official journal of the Japan Pediatric Society 44 293-299 2002年06月
High-dose chemotherapy in children with metastatic hepatoblastoma.
Nishimura S, Sato T, Fujita N, Yamaoka H, Hiyama E, Yokoyama T, Ueda K
Pediatrics international : official journal of the Japan Pediatric Society 44 300-305 2002年06月
[Construction of the functional glycolipid-cluster].
Niikura K, Nishimura S
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 47 543-550 2002年03月
Erythrocyte-like liposomes prepared by means of amphiphilic cyclodextrin sulfates.
Sukegawa T, Furuike T, Niikura K, Yamagishi A, Monde K, Nishimura S
Chemical communications (Cambridge, England)  430-431 2002年03月
Encounter with unexpected collagenase-1 selective inhibitor: switchover of inhibitor binding pocket induced by fluorine atom.
Sawa M, Kondo H, Nishimura S
Bioorganic & medicinal chemistry letters 12 581-584 2002年02月
Germ cell survival through carbohydrate-mediated interaction with Sertoli cells.
Akama TO, Nakagawa H, Sugihara K, Narisawa S, Ohyama C, Nishimura S, O'Brien DA, Moremen KW, Millan JL, Fukuda MN
Science (New York, N.Y.) 295 124-127 2002年01月

書籍

Methods in ENZYMOLOGY
Elsevier 2010年
Methods in ENZYMOLOGY
Elsevier 2010年
Glycoscience 2nd Edition. 1859-1871
Springer 2008年
Glycoscience 2nd Edition. 2115-2119
Springer 2008年
Comprehensive Glycoscience, 453-475
Elsevier Ltd. 2007年
糖鎖のMALDI-TOFMSスペクトルデータブック (西村 紳一郎、福島信弘編)
三共出版 2007年
Methods in Enzymology, 415, 202-212
Academic Press 2006年
Nanotechnology in Carbohydrate Chemistry (Yuasa H.監), 149-166
Transworld Research Network 2006年
Handbook of Carbohydrate Engineering (Yarema K. 編), 495-505
Taylor & Francis 2005年
未来を拓く糖鎖科学 (永井克彦監), 419-420
金芳堂 2005年
書籍を全て表示する
書籍閉じる
Methods in ENZYMOLOGY
Elsevier 2010年
Methods in ENZYMOLOGY
Elsevier 2010年
Glycoscience 2nd Edition. 1859-1871
Springer 2008年
Glycoscience 2nd Edition. 2115-2119
Springer 2008年
Comprehensive Glycoscience, 453-475
Elsevier Ltd. 2007年
糖鎖のMALDI-TOFMSスペクトルデータブック (西村 紳一郎、福島信弘編)
三共出版 2007年
Methods in Enzymology, 415, 202-212
Academic Press 2006年
Nanotechnology in Carbohydrate Chemistry (Yuasa H.監), 149-166
Transworld Research Network 2006年
Handbook of Carbohydrate Engineering (Yarema K. 編), 495-505
Taylor & Francis 2005年
未来を拓く糖鎖科学 (永井克彦監), 419-420
金芳堂 2005年
糖鎖生物学入門 (Maureen E. Taylor, Kurt Drickamer 著)
化学同人 2005年
Carbohydrate-based Drug Discovery, 129-136
Wiley-VCH, DEU 2003年
Methods in Enzymology, 362, 273-286
Academic Press 2003年

受賞

2009年
日本学術会議会長賞 大規模糖鎖解析装置及び疾患マーカー探索技術の開発 
2008年
第62回北海道新聞文化賞 
2006年
第5回グリーン・サスティナブル・ケミストリー賞 経済産業大臣賞 人工ゴルジ装置による複合糖質の自動合成法 
2005年09月
GSC イノベーションジャパン2005 UBSスペシャルアワード優秀賞 複合糖質糖鎖精製キット S-Bio BlotGlyco 
1999年03月
日本化学会 日本化学会 第16回学術賞 効率的糖鎖構築法の創製と複合糖質の機能解明への応用 
1998年07月
日本糖質学会 第1回日本糖質学会奨励賞 複合糖質の機能解明とその応用 
受賞を全て表示する
受賞閉じる
2009年
日本学術会議会長賞 大規模糖鎖解析装置及び疾患マーカー探索技術の開発 
2008年
第62回北海道新聞文化賞 
2006年
第5回グリーン・サスティナブル・ケミストリー賞 経済産業大臣賞 人工ゴルジ装置による複合糖質の自動合成法 
2005年09月
GSC イノベーションジャパン2005 UBSスペシャルアワード優秀賞 複合糖質糖鎖精製キット S-Bio BlotGlyco 
1999年03月
日本化学会 日本化学会 第16回学術賞 効率的糖鎖構築法の創製と複合糖質の機能解明への応用 
1998年07月
日本糖質学会 第1回日本糖質学会奨励賞 複合糖質の機能解明とその応用 

競争的資金等の研究課題

翻訳後修飾のメカニズムと機能の解明/創薬技術開発
研究期間 : 1993年
競争的資金等の研究課題を全て表示する
競争的資金等の研究課題閉じる
翻訳後修飾のメカニズムと機能の解明/創薬技術開発
研究期間 : 1993年

教育活動

主要な担当授業

創薬科学特別講義
開講年度 : 2015年
課程区分 : 修士課程
開講学部 : 大学院共通科目
キーワード : 創薬、ゲノム、糖鎖、ドラッグデザイン、スクリーニング【Key Words】drug discovery, genome, sugar chain, drug design, drug screening
応用生物有機化学
開講年度 : 2015年
課程区分 : 学士課程
開講学部 : 理学部
キーワード : 生体有機化合物、炭水化物、糖、オリゴ糖、多糖、アミノ酸、ペプチド、タンパク質、触媒作用、分子内反応、酵素触媒反応、補酵素、ビタミン、代謝、脂質、テルペン、ステロイド、ヌクレオシド、ヌクレオチド、核酸、医薬品
生命機能制御科学特論
開講年度 : 2015年
課程区分 : 修士課程
開講学部 : 生命科学院
キーワード : 糖鎖生物学、糖鎖工学、糖鎖構造解析法、相互作用解析法、機能解明法、抗体医薬
生命融合科学概論
開講年度 : 2015年
課程区分 : 修士課程
開講学部 : 生命科学院
キーワード : 生命融合科学、生命情報分子科学、生命物質科学、細胞機能科学、生命機能制御科学
生命融合科学概論
開講年度 : 2015年
課程区分 : 修士課程
開講学部 : 理工系大学院
キーワード : 生命融合科学、生命情報分子科学、生命物質科学、細胞機能科学、生命機能制御科学
最新年度を全て表示する
主要な担当授業閉じる
創薬科学特別講義
開講年度 : 2015年
課程区分 : 修士課程
開講学部 : 大学院共通科目
キーワード : 創薬、ゲノム、糖鎖、ドラッグデザイン、スクリーニング【Key Words】drug discovery, genome, sugar chain, drug design, drug screening
応用生物有機化学
開講年度 : 2015年
課程区分 : 学士課程
開講学部 : 理学部
キーワード : 生体有機化合物、炭水化物、糖、オリゴ糖、多糖、アミノ酸、ペプチド、タンパク質、触媒作用、分子内反応、酵素触媒反応、補酵素、ビタミン、代謝、脂質、テルペン、ステロイド、ヌクレオシド、ヌクレオチド、核酸、医薬品
生命機能制御科学特論
開講年度 : 2015年
課程区分 : 修士課程
開講学部 : 生命科学院
キーワード : 糖鎖生物学、糖鎖工学、糖鎖構造解析法、相互作用解析法、機能解明法、抗体医薬
生命融合科学概論
開講年度 : 2015年
課程区分 : 修士課程
開講学部 : 生命科学院
キーワード : 生命融合科学、生命情報分子科学、生命物質科学、細胞機能科学、生命機能制御科学
生命融合科学概論
開講年度 : 2015年
課程区分 : 修士課程
開講学部 : 理工系大学院
キーワード : 生命融合科学、生命情報分子科学、生命物質科学、細胞機能科学、生命機能制御科学
前年度を全て表示する
主要な担当授業閉じる
創薬科学特別講義
開講年度 : 2014年
科目学籍区分名 : 修士課程
科目学部名 : 大学院共通科目
キーワード : 創薬、ゲノム、糖鎖、ドラッグデザイン、スクリーニング【Key Words】drug discovery, genome, sugar chain, drug design, drug screening
応用生物有機化学
開講年度 : 2014年
科目学籍区分名 : 学士課程
科目学部名 : 理学部
キーワード : 生体有機化合物、炭水化物、糖、オリゴ糖、多糖、アミノ酸、ペプチド、タンパク質、触媒作用、分子内反応、酵素触媒反応、補酵素、ビタミン、代謝、脂質、テルペン、ステロイド、ヌクレオシド、ヌクレオチド、核酸、医薬品
生命機能制御科学特論
開講年度 : 2014年
科目学籍区分名 : 修士課程
科目学部名 : 生命科学院
キーワード : 糖鎖生物学、糖鎖構造解析法、相互作用解析法、機能解明手法、革新的技術開発【Key Words】Glycobiology, Analysis method for glycan structure, Analysis method for molecular interaction, Technique for functional analysis, innovative technique development
生命融合科学概論
開講年度 : 2014年
科目学籍区分名 : 修士課程
科目学部名 : 生命科学院
キーワード : 生命融合科学、生命情報分子科学、生命物質科学、細胞機能科学、生命機能制御科学【Key Words】Transdisciplinary Life Science, Bioinformation and Molecular Sciences, Biomaterials Science, Functional Cellular Sciences, Functional and Regulatory Life Sciences
生命融合科学概論
開講年度 : 2014年
科目学籍区分名 : 修士課程
科目学部名 : 理工系大学院
キーワード : 生命融合科学、生命情報分子科学、生命物質科学、細胞機能科学、生命機能制御科学【Key Words】Transdisciplinary Life Science, Bioinformation and Molecular Sciences, Biomaterials Science, Functional Cellular Sciences, Functional and Regulatory Life Sciences
前々年度を全て表示する
主要な担当授業閉じる
創薬科学特別講義
開講年度 : 2013年
科目学籍区分名 : 修士課程
科目学部名 : 大学院共通科目
キーワード : 創薬、ゲノム、糖鎖、ドラッグデザイン、スクリーニング【Key Words】drug discovery, genome, sugar chain, drug design, drug screening
応用生物有機化学
開講年度 : 2013年
科目学籍区分名 : 学士課程
科目学部名 : 理学部
キーワード : 生体有機化合物、炭水化物、糖、オリゴ糖、多糖、アミノ酸、ペプチド、タンパク質、触媒作用、分子内反応、酵素触媒反応、補酵素、ビタミン、代謝、脂質、テルペン、ステロイド、ヌクレオシド、ヌクレオチド、核酸、医薬品
環境と人間
開講年度 : 2013年
科目学籍区分名 : 学士課程
科目学部名 : 全学教育
キーワード : 生命科学、物質、生物、化学、物理、数学、融合科学、細胞、遺伝子、タンパク質、生体高分子
生命機能制御科学特論
開講年度 : 2013年
科目学籍区分名 : 修士課程
科目学部名 : 生命科学院
キーワード : 糖鎖生物学、糖鎖構造解析法、相互作用解析法、機能解明手法、革新的技術開発【Key Words】Glycobiology, Analysis method for glycan structure, Analysis method for molecular interaction, Technique for functional analysis, innovative technique development
生命融合科学概論
開講年度 : 2013年
科目学籍区分名 : 修士課程
科目学部名 : 生命科学院
キーワード : 生命融合科学、生命情報分子科学、生命物質科学、細胞機能科学、生命機能制御科学【Key Words】Transdisciplinary Life Science, Bioinformation and Molecular Sciences, Biomaterials Science, Functional Cellular Sciences, Functional and Regulatory Life Sciences
生命融合科学概論
開講年度 : 2013年
科目学籍区分名 : 修士課程
科目学部名 : 理工系大学院
キーワード : 生命融合科学、生命情報分子科学、生命物質科学、細胞機能科学、生命機能制御科学【Key Words】Transdisciplinary Life Science, Bioinformation and Molecular Sciences, Biomaterials Science, Functional Cellular Sciences, Functional and Regulatory Life Sciences

社会貢献

委員歴

2006年
-
2007年
高分子学会 北海道支部長
2006年
高分子学会 理事
2008年
高分子学会 代議員
2006年
日本バイオマテリアル学会 評議員
委員歴を全て表示する
委員歴閉じる
2006年
-
2007年
高分子学会 北海道支部長
2006年
高分子学会 理事
2008年
高分子学会 代議員
2006年
日本バイオマテリアル学会 評議員

ページトップへ