Hotta Kiyohiko
| Faculty of Medicine Surgery Surgery | Associate Professor |
Last Updated :2025/06/07
■Researcher basic information
Mail Address
- k-hotta
med.hokudai.ac.jp
Researchmap personal page
Researcher number
- 90443936
J-Global ID
Educational Organization
- Master's degree program, Graduate School of Medicine
- Doctoral (PhD) degree program, Graduate School of Medicine
■Career
Educational Background
■Research activity information
Papers
- Surgical technique analysis using dynamic measurement of surgical instruments for practical laparoscopic surgery training*
Lingbo Yan, Takashige Abe, Koki Ebina, Masafumi Kon, Madoka Higuchi, Kiyohiko Hotta, Jun Furumido, Naoya Iwahara, Shunsuke Komizunai, Teppei Tsujita, Kazuya Sase, Xiaoshuai Chen, Yo Kurashima, Hiroshi Kikuchi, Haruka Miyata, Ryuji Matsumoto, Takahiro Osawa, Sachiyo Murai, Toshiaki Shichinohe, Soichi Murakami, Taku Senoo, Masahiko Watanabe, Atsushi Konno
2025 IEEE/SICE International Symposium on System Integration (SII), 271, 274, IEEE, 21 Jan. 2025, [Peer-reviewed]
International conference proceedings - 腎移植後に発症し,完全寛解を得た転移性精巣腫瘍の1例
東海林 旺次朗, 安部 崇重, 堀田 記世彦, 岩見 大基, 田邉 起, 大澤 崇宏, 松本 隆児, 広瀬 貴行, 菊地 央, 宮田 遥, 岩原 直也, 山田 修平, 篠原 信雄
泌尿器科紀要, 71, 1, 9, 15, 泌尿器科紀要刊行会, Jan. 2025
Japanese - Development of a Hybrid Measurement System for Surgical Instrument Motion of Laparoscopic Surgery
Koki Ebina, Takashige Abe, Lingbo Yan, Kiyohiko Hotta, Chihiro Kamijo, Madoka Higuchi, Masafumi Kon, Hiroshi Kikuchi, Haruka Miyata, Ryuji Matsumoto, Takahiro Osawa, Sachiyo Murai, Yo Kurashima, Toshiaki Shichinohe, Masahiko Watanabe, Shunsuke Komizunai, Teppei Tsujita, Kazuya Sase, Xiaoshuai Chen, Taku Senoo, Nobuo Shinohara, Atsushi Konno
IEEE Transactions on Medical Robotics and Bionics, 1, 1, Institute of Electrical and Electronics Engineers (IEEE), 2025
Scientific journal - [A Case of Metastatic Testicular Cancer after Kidney Transplantation in which Complete Remission was Achieved].
Ojiro Tokairin, Takashige Abe, Kiyohiko Hotta, Daiki Iwami, Tatsu Tanabe, Takahiro Osawa, Ryuji Matsumoto, Takayuki Hirose, Hiroshi Kikuchi, Haruka Miyata, Naoya Iwahara, Shuhei Yamada, Nobuo Shinohara
Hinyokika kiyo. Acta urologica Japonica, 71, 1, 9, 15, Jan. 2025, [Domestic magazines]
Japanese, Scientific journal, We report a case of testicular cancer after kidney transplantation in a 29-year-old man. Twenty-two years after the surgery, computed tomography (CT) showed a retroperitoneal mass 3 cm in diameter. Positron emission tomography (PET) -CT revealed high FDG uptake in both the right testis and retroperitoneal mass. Regarding serum tumor markers, α fetoprotein (AFP) was slightly elevated to 12.5 ng/ml. He underwent right radical orchiectomy, and pathological examination revealed pure seminoma. After surgery, the serum AFP level remained high (12. 9 ng/ml), and we initially considered this nonseminoma patient to have a good prognosis according to International Germ Cell Consensus Classification. During three cycles of a combination regimen including bleomycin, etoposide, and cisplatin (BEP), we performed adjustment of immunosuppressive therapy, treatment for Cytomegalovirus infection (valganciclovir hydrochloride), and that for other adverse events associated with systemic chemotherapy. The chemotherapy schedule was delayed, and bleomycin (third course, day 15) was skipped due to adverse effects. After 3 cycles of BEP, the retroperitoneal lymph node metastasis shrunk from 3.0 to 1.5 cm in diameter. In contrast to the good radiological response, the serum AFP level gradually increased during the treatment to 102.6 ng/ml. Therefore, we did not consider the AFP elevation to have derived from residual cancer, and decided to perform close follow-up. During the 3-year follow-up, AFP decreased to around 20 ng/ml, and PET-CT did not show any uptake in the retroperitoneal mass or other sites. - Successful kidney transplantation improves atrophic bladder capacity and function within 3 months in long‐term dialysis patients
Tatsuya Hoshi, Takayuki Hirose, Kanako Fuyama, Naoya Iwahara, Hiroki Chiba, Kiyohiko Hotta
International Journal of Urology, 05 Nov. 2024
English, Scientific journal - モーションキャプチャーを用いた熟練者の腹腔鏡手術鉗子動態の数値化・言語化の試み
安部 崇重, 今 雅史, 樋口 まどか, 岩原 直也, 堀田 記世彦, 菊地 央, 宮田 遥, 松本 隆児, 大澤 崇宏
日本泌尿器内視鏡・ロボティクス学会総会, 38回, AP4, 6, (一社)日本泌尿器内視鏡・ロボティクス学会, Nov. 2024
Japanese - 若手修練医の腹腔鏡手術トレーニングにおけるラーニングカーブの特徴
上條 千太, 堀田 記世彦, 樋口 まどか, 今 雅史, 松本 隆児, 大澤 崇宏, 安部 崇重
日本泌尿器内視鏡・ロボティクス学会総会, 38回, O8, 4, (一社)日本泌尿器内視鏡・ロボティクス学会, Nov. 2024
Japanese - Protocol biopsy of kidney allograft enables early detection of BK virus nephropathy to preserve kidney allograft function
Naoya Iwahara, Kiyohiko Hotta, Takayuki Hirose, Hiromi Okada, Nobuo Shinohara
Transplant Infectious Disease, Wiley, 09 Jul. 2024
Scientific journal, Abstract
Background
The Banff Working Group has updated the histological classification of BK virus nephropathy (BKVN), highlighting the importance of early detection. However, an early detection strategy for BKVN using biopsy has not yet been established. Our investigation aimed to assess the efficacy of protocol biopsy for the diagnosis of BKVN.
Methods
We performed a retrospective cohort study of 314 patients who had undergone kidney transplantation between 2006 and 2021. Kidney allograft biopsies were performed as part of a protocol biopsy at 3 months and 1 year post‐transplantation. Following the diagnosis of BKVN, the immunosuppressant dose was reduced.
Results
Twelve patients (3.8%) were diagnosed with BKVN by biopsy. Most diagnoses are established during the early stages of BKVN (polyomavirus nephropathy class 1 in six, class 2 in five, and class 3 in one). Following the reduction in immunosuppressant dose, kidney allograft function did not deteriorate in any patients. Additionally, test for BK virus DNA in the blood was negative. All but one patient demonstrated histological resolution of BKVN, and the other had a very slight positivity for the simian virus 40 large T antigen. The median follow‐up time after BKVN diagnosis was 6 years. One patient developed de novo donor‐specific antibody and subclinical acute antibody‐mediated rejection that was successfully cured.
Conclusions
Our analysis indicates that protocol biopsy may enable the early detection of BKVN, resulting in the preservation of kidney function.image - A surgical instrument motion measurement system for skill evaluation in practical laparoscopic surgery training
Koki Ebina, Takashige Abe, Lingbo Yan, Kiyohiko Hotta, Toshiaki Shichinohe, Madoka Higuchi, Naoya Iwahara, Yukino Hosaka, Shigeru Harada, Hiroshi Kikuchi, Haruka Miyata, Ryuji Matsumoto, Takahiro Osawa, Yo Kurashima, Masahiko Watanabe, Masafumi Kon, Sachiyo Murai, Shunsuke Komizunai, Teppei Tsujita, Kazuya Sase, Xiaoshuai Chen, Taku Senoo, Nobuo Shinohara, Atsushi Konno
PLOS ONE, 19, 6, e0305693, e0305693, Public Library of Science (PLoS), 25 Jun. 2024
Scientific journal, This study developed and validated a surgical instrument motion measurement system for skill evaluation during practical laparoscopic surgery training. Owing to the various advantages of laparoscopic surgery including minimal invasiveness, this technique has been widely used. However, expert surgeons have insufficient time for providing training to beginners due to the shortage of surgeons and limited working hours. Skill transfer efficiency has to be improved for which there is an urgent need to develop objective surgical skill evaluation methods. Therefore, a simple motion capture–based surgical instrument motion measurement system that could be easily installed in an operating room for skill assessment during practical surgical training was developed. The tip positions and orientations of the instruments were calculated based on the marker positions attached to the root of the instrument. Because the patterns of these markers are individual, this system can track multiple instruments simultaneously and detect exchanges. However due to the many obstacles in the operating room, the measurement data included noise and outliers. In this study, the effect of this decrease in measurement accuracy on feature calculation was determined. Accuracy verification experiments were conducted during wet-lab training to demonstrate the capability of this system to measure the motion of surgical instruments with practical accuracy. A surgical training experiment on a cadaver was conducted, and the motions of six surgical instruments were measured in 36 cases of laparoscopic radical nephrectomy. Outlier removal and smoothing methods were also developed and applied to remove the noise and outliers in the obtained data. The questionnaire survey conducted during the experiment confirmed that the measurement system did not interfere with the surgical operation. Thus, the proposed system was capable of making reliable measurements with minimal impact on surgery. The system will facilitate surgical education by enabling the evaluation of skill transfer of surgical skills. - 2次腎移植後に水痘帯状疱疹ウイルス脳炎を発症した1例
氏家 卓弥, 岩原 直也, 堀田 記世彦, 広瀬 貴行, 伊藤 史恵, 上床 尚, 挽地 史織, 藤原 圭志, 篠原 信雄
日本臨床腎移植学会プログラム・抄録集, 57回, 237, 237, (一社)日本臨床腎移植学会, Feb. 2024
Japanese - Longitudinal mortality risks and kidney functional outcomes in Japanese living kidney donors.
Takayuki Hirose, Kiyohiko Hotta, Takahiro Osawa, Isao Yokota, Tasuku Inao, Tatsu Tanabe, Naoya Iwahara, Nobuo Shinohara
International journal of urology : official journal of the Japanese Urological Association, 19 Jan. 2024, [International Magazine]
English, Scientific journal, OBJECTIVES: Previous studies suggested that living kidney donors do not have a higher risk of death or kidney failure than the general population. However, living kidney donor risk is controversial. Furthermore, only a few studies have evaluated long-term kidney function after kidney donation. METHODS: This study evaluated Japanese kidney donor' long-term outcomes, including mortality and kidney function. From 1965 to 2015, 230 donors (76 males, 154 females, and a median age of 54) were enrolled in this study. The median observation period was 11.0 (range, 0.3-41.0) years. RESULTS: In total, 215 donors were still alive, and 15 had died. Causes of death included malignancies, cardiovascular disease, pneumonia, suicide, gastrointestinal bleeding, and kidney failure. Actual donor survival rates at 10, 20, and 30 years were 95.3%, 90.7%, and 80.9%, respectively. These values were comparable to age- and gender-matched expected survival. Long-term kidney function after donation was evaluated in 211 donors with serum creatinine data. Two donors developed kidney failure 24 and 26 years post-donation, respectively. The percentage of donors whose estimated glomerular filtration rate (eGFR) remained ≥45 mL/min/1.73 m2 at 10, 20, and 30 years after donation were 84.2%, 73.0%, and 63.9%, respectively. Survival rates of donors with eGFR <45 mL/min/1.73 m2 were comparable to those in persons with eGFR >45 mL/min/1.73 m2 . CONCLUSION: Our findings revealed that kidney donors did not have a higher long-term risk of death than the general population. Although some donors showed decreased kidney function after donation, kidney function did not impact their survival. - 新型コロナウイルス感染蔓延下での長期待機後に脳死肝腎同時移植を実施した末期原発性硬化性胆管炎の1例
坂村 颯真, 後藤 了一, 山口 将功, 植林 毅行, 伊藤 啓一郎, 津坂 翔一, 原田 拓弥, 太田 拓児, 川村 典生, 渡辺 正明, 田邉 起, 堀田 記世彦, 篠原 信雄, 嶋村 剛, 武冨 紹信
北海道外科雑誌, 68, 2, 106, 110, 北海道外科学会, Dec. 2023
Japanese - 【日本移植学会2022年症例登録統計報告】腎移植臨床登録集計報告(2023) 2022年実施症例の集計報告と追跡調査結果
中川 由紀, 三重野 牧子, 市丸 直嗣, 西田 隼人, 中村 道郎, 堀田 記世彦, 尾本 和也, 田崎 正行, 伊藤 泰平, 奥見 雅由, 荒木 元朗, 祖父江 理, 山田 保俊, 島袋 修一, 剣持 敬, 湯沢 賢治, 日本臨床腎移植学会・日本移植学会
移植, 58, 3, 189, 208, (一社)日本移植学会, Dec. 2023
Japanese - 客観的フィードバックが得られる腹腔鏡手術トレーニングモデル構築の試み
安部 崇重, 松本 隆児, 堀田 記世彦, 七戸 俊明, 倉島 庸, 篠原 信雄
日本内視鏡外科学会雑誌, 28, 7, 2919, 2919, (一社)日本内視鏡外科学会, Dec. 2023
Japanese - 【日本移植学会2022年症例登録統計報告】腎移植臨床登録集計報告(2023) 2022年実施症例の集計報告と追跡調査結果
中川 由紀, 三重野 牧子, 市丸 直嗣, 西田 隼人, 中村 道郎, 堀田 記世彦, 尾本 和也, 田崎 正行, 伊藤 泰平, 奥見 雅由, 荒木 元朗, 祖父江 理, 山田 保俊, 島袋 修一, 剣持 敬, 湯沢 賢治, 日本臨床腎移植学会・日本移植学会
移植, 58, 3, 189, 208, (一社)日本移植学会, Dec. 2023
Japanese - Kidney donor age of 50 years or above is a risk factor for calcineurin inhibitor-induced nephrotoxicity.
Yusuke Takada, Tatsu Tanabe, Hajime Sasaki, Takashi Tsujimoto, Kiyohiko Hotta, Kazufumi Okada, Yutaka Shiono, Keita Minami, Hiroshi Tanaka, Hiroshi Harada
Clinical transplantation, e15196, 17 Nov. 2023, [International Magazine]
English, Scientific journal, INTRODUCTION: Calcineurin inhibitor (CNI)-induced nephrotoxicity (CNI-T) is a post-transplantation complication that leads to graft dysfunction. Older-donor kidney grafts may be susceptible to chronic CNI exposure because of long-term arteriolar damage. The primary aim of this study was to examine the CNI-T incidence and time-course changes in the graft function according to donor age. METHODS: We included 334 kidney transplant recipients. CNI-T was defined by Banff arteriolar hyaline thickening scores of ≥2 based on allograft protocol biopsy. Depending on donor age, participants were divided into the D > 70 (≥70 years), D60 (60-69 years), D50 (50-59 years), and D < 49: (≤49 years) groups. We investigated the extent to which CNI-T affected the transplanted kidney function. Patients who did not develop CNI-T during the study period were included in the non-CNI-T group; the remaining were grouped into the CNI-T group. RESULTS: The CNI-T incidence was higher in donors aged >50 years. Compared to D < 49, the CNI-T risk was 1.86 times higher in D50 and 2.9 times higher in D > 70. Furthermore, the CNI-T group exhibited a significantly lower graft function 10 years after transplantation. CONCLUSION: CNI-T incidence increases in donors aged ≥50 years and affects renal function after 10 years. - カダバートレーニング時の鉗子動態計測による手術技量の数値化の試み
安部 崇重, 今 雅史, 堀田 記世彦, 樋口 まどか, 菊地 央, 上條 千太, 宮田 遥, 松本 隆児, 大澤 崇宏, 篠原 信雄
日本泌尿器内視鏡・ロボティクス学会総会, 37回, O, 6, (一社)日本泌尿器内視鏡・ロボティクス学会, Nov. 2023
Japanese - 増やそう未来の外科医!働き方改革における外科系教育 泌尿器科手術に関するシミュレーショントレーニング 当科での経験
安部 崇重, 今 雅史, 樋口 まどか, 堀田 記世彦, 菊地 央, 古御堂 純, 岩原 直也, 山田 修平, 原田 茂, 上條 千太, 村井 祥代, 宮田 遥, 松本 隆児, 大澤 崇宏, 篠原 信雄
日本癌治療学会学術集会抄録集, 61回, SWS7, 1, (一社)日本癌治療学会, Oct. 2023
English - Immunological risk and complement genetic evaluations in early onset de novo thrombotic microangiopathy after living donor kidney transplantation: a Japanese multicenter registry.
Nobuhiro Fujiyama, Masayuki Tasaki, Hiroshi Harada, Koichi Tsutahara, Akihiko Matsumoto, Yuji Kamijo, Mariko Toyoda, Daiki Iwami, Masashi Inui, Hiroki Shirakawa, Jun Sugimura, Mitsuru Saito, Kiyohiko Hotta, Masayoshi Okumi, Kazuhide Saito, Yoshihiko Watarai, Yoshihiko Hidaka, Katsuki Ohtani, Norimitsu Inoue, Nobutaka Wakamiya, Tomonori Habuchi, Shigeru Satoh
Clinical and experimental nephrology, 27 Aug. 2023, [Domestic magazines]
English, Scientific journal, BACKGROUND: Thrombotic microangiopathy (TMA) after kidney transplantation (KTx), particularly early onset de novo (dn) TMA, requires immediate interventions to prevent irreversible organ damage. This multicenter study was performed to investigate the allogeneic clinical factors and complement genetic background of dnTMA after KTx. METHODS: Perioperative dnTMA after KTx within 1 week after KTx were diagnosed based on pathological or/and hematological criteria at each center, and their immunological backgrounds were researched. Twelve aHUS-related gene variants were examined in dnTMA cases. RESULTS: Seventeen recipients (15 donors) were enrolled, and all dnTMA cases were onset within 72-h of KTx, and 16 of 17 cases were ABO incompatible. The implementation rate of pre-transplant plasmaphereses therapies were low, including cases with high titers of anti-A/anti-B antibodies. Examination of aHUS-related gene variants revealed some deletions and variants with minor allele frequency (MAF) in Japan or East Asian genome databases in genes encoding alternative pathways and complement regulatory factors. These variants was positive in 8 cases, 6 of which were positive in both recipient and donor, but only in one graft loss case. CONCLUSIONS: Although some immunological risks were found for dnTMA after KTx, only a few cases developed into TMA. The characteristic variations revealed in the present study may be novel candidates related to dnTMA in Japanese or Asian patients, but not pathogenic variants of aHUS. Future studies on genetic and antigenic factors are needed to identify factors contributing to dnTMA after KTx. - Prophylactic bilateral nephrectomy and preemptive kidney transplantation for Denys–Drash syndrome prior to development of kidney failure
Chika Hosokawa, Kiyohiko Hotta, Takayuki Okamoto, Yuko Cho, Takayuki Hirose, Naoya Iwahara, Atsushi Manabe, Nobuo Shinohara
Pediatric Nephrology, 12 Aug. 2023, [Peer-reviewed]
Scientific journal - Long-Term Results in Recipients of Late Conversion to a Calcineurin Inhibitor-Free Regimen with Everolimus After Kidney Transplantation
Naoya Iwahara, Kiyohiko Hotta, Takayuki Hirose, Nobuo Shinohara
Transplantation Proceedings, 55, 4, 803, 808, Elsevier BV, May 2023
Scientific journal - 耐糖能異常症例における腎移植後の耐糖能,インスリン分泌,インスリン抵抗性の変化
宮本 麻唯子, 中村 昭伸, 宮 愛香, 野本 博司, 亀田 啓, 曹 圭龍, 堀田 記世彦, 篠原 信雄, 三好 秀明, 渥美 達也
糖尿病, 66, Suppl.1, S, 309, (一社)日本糖尿病学会, Apr. 2023
Japanese - 腎移植後の耐糖能改善は移植前の維持透析療法の有無に影響されない
宮本 麻唯子, 中村 昭伸, 宮 愛香, 野本 博司, 亀田 啓, 曹 圭龍, 堀田 記世彦, 篠原 信雄, 三好 秀明, 渥美 達也
糖尿病, 66, 2, 173, 173, (一社)日本糖尿病学会, Feb. 2023
Japanese - Use of Mixed Lymphocyte Reaction Assay to Evaluate Immune Tolerance before Kidney Transplantation with an Immunosuppression-Free Protocol following Hematopoietic Stem Cell Transplantation from the Same Donor.
Sho Nonoyama, Kiyohiko Hotta, Naoya Iwahara, Tatsu Tanabe, Takayuki Hirose, Shigeru Harada, Sugita Junichi, Daigo Nakazawa, Akio Shigematsu, Takuya Otsuka, Nobuo Shinohara
Nephron, 147, 10, 621, 626, 2023, [International Magazine]
English, Several cases of kidney transplantation after hematopoietic stem cell transplantation (HSCT) from the same donor for end-stage renal disease have been reported. In those cases, immunosuppressive drugs were discontinued since immune tolerance was supposed to be induced. Theoretically, the recipient's immune system recognizes the kidney allograft as its own tissue with the same human leukocyte antigen (HLA) profile, and the kidney allograft will not be rejected, even without the use of immunosuppressive agents. However, almost all recipients receive immunosuppressants in the early stages after kidney transplantation owing to concerns of acute rejection. Here, we report a successful case of post-HSCT kidney transplantation without the use of immunosuppressive drugs, in which a mixed lymphocyte reaction (MLR) assay was used to evaluate immune tolerance before kidney transplantation. The patient was a 25-year-old woman. Five years prior, she developed acute myeloid leukemia and underwent HLA-half-matched peripheral blood stem cell transplantation. Thereafter, she was in remission of the acute myeloid leukemia, but 1 year later, she developed renal graft-versus-host disease. Subsequently, the patient's renal function gradually deteriorated to end-stage renal failure, and she underwent kidney transplantation with the previous stem cell donor: her mother. HLA typing of donor and recipient showed a complete chimerism in the peripheral blood. The pretransplantation complement-dependent cytotoxic crossmatch and flow cytometric T-cell crossmatch results were both negative, and HLA antibody measurements were all negative. The MLR assay revealed no T-lymphocyte reaction to the donor; therefore, immunosuppressants were not used. Two years after transplantation, the patient's serum creatinine concentration was around 0.8 mg/dL (down from 4 mg/dL before transplantation). No abnormalities were observed in a renal biopsy performed after 3 months. Our study, along with others, indicates that immune tolerance to a donor develops in post-HSCT kidney transplantation from the same donor. - Development and validation of a measurement system for laparoscopic surgical procedures in practical surgery training.
Koki Ebina, Takashige Abe, Kiyohiko Hotta, Madoka Higuchi, Jun Furumido, Naoya Iwahara, Masafumi Kon, Shunsuke Komizunai, Yo Kurashima, Hiroshi Kikuchi, Ryuji Matsumoto, Takahiro Osawa, Sachiyo Murai, Teppei Tsujita, Kazuya Sase, XiaoShuai Chen, Nobuo Shinohara, Atsushi Konno
IEEE/SICE International Symposium on System Integration(SII), 1, 6, IEEE, 2023
International conference proceedings - Analysis of T-cell alloantigen response via a direct pathway in kidney transplant recipients with donor-specific antibodies.
Naoya Iwahara, Kiyohiko Hotta, Daiki Iwami, Tatsu Tanabe, Yuka Tanaka, Yoichi M Ito, Takuya Otsuka, Sachiyo Murai, Yusuke Takada, Haruka Higuchi, Hajime Sasaki, Takayuki Hirose, Hiroshi Harada, Nobuo Shinohara
Frontiers in immunology, 14, 1164794, 1164794, 2023, [International Magazine]
English, Scientific journal, Donor-specific antibodies (DSAs) are the main cause of graft loss over time. The direct pathway of alloantigen recognition is important in the pathogenesis of acute rejection. Recent studies have suggested that the direct pathway also contributes to the pathogenesis of chronic injury. Nevertheless, there are no reports on T-cell alloantigen response via the direct pathway in kidney recipients with DSAs. We analyzed the T-cell alloantigen response via the direct pathway in kidney recipients with DSAs (DSA+) or without DSAs (DSA-). A mixed lymphocyte reaction assay was implemented to assess the direct pathway response. DSA+ patients showed significantly higher CD8+ and CD4+ T cell responses to donor cells than DSA- patients. Furthermore, proliferating CD4+ T cells showed a marked increase in Th1 and Th17 responses in DSA+ patients than in DSA- patients. In a comparison between anti-donor and third-party responses, the anti-donor CD8+ and CD4+ T cell response was significantly lower than the anti-third-party response. In contrast, the donor-specific hyporesponsiveness was absent in DSA+ patients. Our study demonstrated that DSA+ recipients have a greater potential for developing immune responses against the donor tissues via the direct alloantigen recognition pathway. These data contribute to an understanding of DSAs pathogenicity during kidney transplantation. - 腎移植臨床登録集計報告(2022) 2021年実施症例の集計報告と追跡調査結果
中川 由紀, 三重野 牧子, 市丸 直嗣, 森田 研, 中村 道郎, 堀田 記世彦, 尾本 和也, 田崎 正行, 伊藤 泰平, 牛込 秀隆, 荒木 元朗, 祖父江 理, 山田 保俊, 島袋 修一, 剣持 敬, 湯沢 賢治, 日本臨床腎移植学会
移植, 57, 3, 199, 219, (一社)日本移植学会, Dec. 2022
Japanese - 鉗子動態計測を用いた腹腔鏡手術基本手技の技量評価・客観的フィードバックの試み
安部 崇重, 堀田 記世彦, 松本 隆児, 倉島 庸, 篠原 信雄
日本内視鏡外科学会雑誌, 27, 7, 1418, 1418, (一社)日本内視鏡外科学会, Dec. 2022
Japanese - Clinical trials for renal allograft tolerance induction through combined hematopoietic stem cell transplantation: A narrative review.
Kiyohiko Hotta, Takayuki Hirose, Tatsuo Kawai
International journal of urology : official journal of the Japanese Urological Association, 29, 12, 1397, 1404, Dec. 2022, [International Magazine]
English, Scientific journal, During the last four decades, development of effective immunosuppressants has significantly improved short-term results of organ transplantation. However, long-term results have not been satisfactory due to chronic rejection or complications caused by immunosuppressive drugs. Therefore, induction of immunological tolerance of the transplanted organ is considered essential to improve the long-term results. Despite numerous tolerance strategies that have been successful in murine models, inducing hematopoietic chimerism through donor hematopoietic stem cell transplantation is the only method that reproducibly induces kidney allograft tolerance in nonhuman primates or humans. Combining kidney and hematopoietic stem cell transplantation to achieve allograft tolerance has now been attempted with different chimerism strategies. This review summarizes the status of current clinical trials on the induction of allograft tolerance. We also summarize recent studies to extend the chimerism approach to deceased donor transplant recipients. - 鉗子動態計測を用いた腹腔鏡手術基本手技の技量評価・客観的フィードバックの試み
安部 崇重, 堀田 記世彦, 古御堂 純, 岩原 直也, 今 雅史, 樋口 まどか, 菊地 央, 松本 隆児, 大澤 崇宏, 篠原 信雄
日本泌尿器内視鏡・ロボティクス学会総会, 36回, AP, 7, (一社)日本泌尿器内視鏡・ロボティクス学会, Nov. 2022
Japanese - ステントグラフト内挿術後に外科的治療を要した尿管動脈瘻の1例
杉戸 悠紀, 堀田 記世彦, 山田 修平, 千葉 博基, 松本 隆児, 大澤 崇宏, 安部 崇重, 阿保 大介, 佐藤 公治, 若狭 哲, 篠原 信雄
日本泌尿器科学会雑誌, 113, 4, 134, 138, (一社)日本泌尿器科学会, Oct. 2022
Japanese - 新型コロナウイルス感染蔓延下での長期待機後に脳死肝腎同時移植を実施した末期原発性硬化性胆管炎の1例
植林 毅行, 後藤 了一, 山口 将功, 伊藤 啓一郎, 津坂 翔一, 原田 拓弥, 太田 拓児, 川村 典生, 渡辺 正明, 増谷 祥, 秋山 久, 田邉 起, 堀田 記世彦, 篠原 信雄, 嶋村 剛, 武冨 紹信
日本臨床外科学会雑誌, 83, 10, 1839, 1840, 日本臨床外科学会, Oct. 2022
Japanese - ステントグラフト内挿術後に外科的治療を要した尿管動脈瘻の1例
杉戸 悠紀, 堀田 記世彦, 山田 修平, 千葉 博基, 松本 隆児, 大澤 崇宏, 安部 崇重, 阿保 大介, 佐藤 公治, 若狭 哲, 篠原 信雄
日本泌尿器科学会雑誌, 113, 4, 134, 138, (一社)日本泌尿器科学会, Oct. 2022
Japanese - 耐糖能異常症例における腎移植後の耐糖能変化はインスリン分泌能の変化と関連する
中村 昭伸, 宮本 麻唯子, 宮 愛香, 野本 博司, 亀田 啓, 曹 圭龍, 堀田 記世彦, 篠原 信雄, 三好 秀明, 渥美 達也
糖尿病合併症, 36, Suppl.1, 195, 195, (一社)日本糖尿病合併症学会, Sep. 2022
Japanese - Banff Human Organ Transplant Transcripts Correlate with Renal Allograft Pathology and Outcome: Importance of Capillaritis and Subpathologic Rejection
Ivy A. Rosales, Grace K. Mahowald, Kristen Tomaszewski, Kiyohiko Hotta, Naoya Iwahara, Takuya Otsuka, Takahiro Tsuji, Yusuke Takada, Ellen Acheampong, Milagros Araujo-Medina, Amy Bruce, Andrea Rios, Anthony Benedict Cosimi, Nahel Elias, Tatsuo Kawai, Hannah Gilligan, Kassem Safa, Leonardo V. Riella, Nina E. Tolkoff-Rubin, Winfred W. Williams, Rex Neal Smith, Robert B. Colvin
Journal of the American Society of Nephrology, ASN.2022040444, ASN.2022040444, American Society of Nephrology (ASN), 31 Aug. 2022
Scientific journal, BackgroundTo seek insights into the pathogenesis of chronic active antibody–mediated rejection (CAMR), we performed mRNA analysis and correlated transcripts with pathologic component scores and graft outcomes.
MethodsWe utilized the NanoString nCounter platform and the Banff Human Organ Transplant gene panel to quantify transcripts on 326 archived renal allograft biopsy samples. This system allowed correlation of transcripts with Banff pathology scores from the same tissue block and correlation with long-term outcomes.
ResultsThe only pathology score that correlated with AMR pathways in CAMR was peritubular capillaritis (ptc). C4d, cg, g, v, i, t, or ci scores did not correlate. DSA-negative CAMR had lower AMR pathway scores than DSA-positive CAMR. Transcript analysis in non-CAMR biopsies yielded evidence of increased risk of later CAMR. Among 108 patients without histologic CAMR, 23 developed overt biopsy-documented CAMR within 5 years and as a group had higher AMR pathway scores (P=3.4 × 10–5). Random forest analysis correlated 3-year graft loss with elevated damage, innate immunity, and macrophage pathway scores in CAMR and TCMR. Graft failure in CAMR was associated with TCMR transcripts but not with AMR transcripts, and graft failure in TCMR was associated with AMR transcripts but not with TCMR transcripts.
ConclusionsPeritubular capillary inflammation and DSA are the primary drivers of AMR transcript elevation. Transcripts revealed subpathological evidence of AMR, which often preceded histologic CAMR and subpathological evidence of TCMR that predicted graft loss in CAMR.
- Response to Re: Vesicoureteral reflux treatment following kidney transplantation potentially prevents graft function deterioration and allows long-term graft survival.
Takayuki Hirose, Kiyohiko Hotta, Nobuo Shinohara
International journal of urology : official journal of the Japanese Urological Association, 24 Aug. 2022, [International Magazine]
English - THE DEVELOPMENT OF SKILL EVALUATION SYSTEM FOR LAPAROSCOPIC SURGICAL PROCEDURE
EBINA KOKI, ABE TAKASHIGE, HOTTA KIYOHIKO, HIGUCHI MADOKA, FURUMIDO JUN, IWAHARA NAOYA, KON MASAFUMI, KOMIZUNAI SHUNSUKE, KURASHIMA YO, KIKUCHI HIROSHI, MATSUMOTO RYUJI, OSAWA TAKAHIRO, MURAI SACHIYO, TSUJITA TEPPEI, SASE KAZUYA, CHEN XIAOSHUAI, SHINOHARA NOBUO, KONNO ATSUSHI
Proceedings of Jc-IFToMM International Symposium, 5, 73, 79, Japanese Council of IFToMM, 16 Jul. 2022
English, This paper describes details of the development of skill evaluation system for laparoscopic surgical procedure. The measurement experiment was conducted for 70 surgeons, and the participants perform 2 tasks: tissue dissection around the aorta and renal parenchymal suturing/knotting using porcine cadaver. In the experiments, the movement of surgical instruments were recorded by motion capture (MoCap) system, and the motion indices were calculated. The participants grouped into three classes (novices, intermediates, and experts) according to their level of experience. Three classification algorithms: support vector machine (SVM), principal component based SVM (PCA-SVM), gradient boosting decision tree (GBDT) were utilized for developing the model of classifier. The accuracy of each model was assessed by nested and repeated k-fold cross validation. Regarding 3-class classification, the GBDT method resulted highest accuracy (the median of the accuracy is A_med = 68.6 %) in the dissection tasks. In the suturing/knotting tasks, PCA-SVM resulted highest accuracy (A_med = 58.4 %). Regarding 2-class classification (experts vs. intermediates/novices), the GBDT method resulted A_med = 72.9 % in the dissection task, and the PCA-SVM method resulted A_med = 69.2 % in the suturing task. This result shows the MoCap based skill evaluation system in wet-lab training could be a practical way to objectively assess trainees' surgical competence. - 外科教育の実践とキャリア 当科で行ってきた手術シミュレーショントレーニングの経験
安部 崇重, 今 雅史, 樋口 まどか, 菊地 央, 岩原 直也, 古御堂 純, 堀田 記世彦, 松本 隆児, 大澤 崇宏, 篠原 信雄
医学教育, 53, Suppl., 26, 26, (一社)日本医学教育学会, Jul. 2022
Japanese - 外科教育の実践とキャリア 当科で行ってきた手術シミュレーショントレーニングの経験
安部 崇重, 今 雅史, 樋口 まどか, 菊地 央, 岩原 直也, 古御堂 純, 堀田 記世彦, 松本 隆児, 大澤 崇宏, 篠原 信雄
医学教育, 53, Suppl., 26, 26, (一社)日本医学教育学会, Jul. 2022
Japanese - Vesicoureteral reflux treatment following kidney transplantation potentially prevents graft function deterioration and allows long-term graft survival.
Takayuki Hirose, Kiyohiko Hotta, Hiroshi Harada, Tatsu Tanabe, Hajime Sasaki, Nobuo Shinohara
International journal of urology : official journal of the Japanese Urological Association, 29, 7, 699, 706, Jul. 2022, [International Magazine]
English, Scientific journal, OBJECTIVES: The impact of vesicoureteral reflux post-kidney transplantation on graft survival remains unclear, and guidelines on appropriate vesicoureteral reflux management post-kidney transplantation are lacking. For this reason, we conducted a retrospective study on the impact of vesicoureteral reflux and its treatment on graft survival. METHODS: We evaluated 347 consecutive kidney transplantation recipients, who also underwent a ureteroneocystostomy, between 1996 and 2012. RESULTS: Vesicoureteral reflux was diagnosed in 55 cases (15.9%), with a median post-kidney transplantation duration of 50 months (range 0-172 months). Among these, 22 were monitored, 17 underwent transurethral collagen injections, and 16 received a ureteroneocystostomy. The 10-year graft survival rate was significantly lower in recipients with vesicoureteral reflux (68.9%) than in those without vesicoureteral reflux (84.4%) (P = 0.0165). Moreover, among the vesicoureteral reflux recipients, the 10-year graft survival rate was significantly higher in those whose vesicoureteral reflux was cured (80.1%) than in those whose vesicoureteral reflux persisted (53.6%) (P = 0.0062). Multivariate analysis showed that vesicoureteral reflux was significantly associated with both overall and death-censored graft loss (odds ratio 3.737 and 3.685; P = 0.0015 and P = 0.0052, respectively). Lastly, the incidence of interstitial fibrosis and tubular atrophy was higher in recipients with vesicoureteral reflux than in those without vesicoureteral reflux (P = 0.0009). CONCLUSIONS: Post-kidney transplantation vesicoureteral reflux has a negative impact on long-term graft survival, and that treatment prevents graft deterioration. From the perspective of maintaining long-term graft function in kidney recipients, vesicoureteral reflux may be one of the most important complications to be addressed. - FCXM T細胞偽陽性を呈したABO血液型不適合腎移植の5例
林 綾香, 山本 泉, 川邊 万佑子, 小林 賛光, 伊藤 誠, 堀田 記世彦, 篠原 信雄, 田崎 哲典, 横尾 隆, 岩見 大基
日本腎臓学会誌, 64, 3, 233, 233, (一社)日本腎臓学会, May 2022
Japanese - 耐糖能異常患者における腎移植後の耐糖能変化及びその関連因子
久住 麻唯子, 中村 昭伸, 宮 愛香, 野本 博司, 亀田 啓, 曹 圭龍, 堀田 記世彦, 篠原 信雄, 三好 秀明, 渥美 達也
糖尿病, 65, Suppl.1, S, 290, (一社)日本糖尿病学会, Apr. 2022
Japanese - 腎移植後のB型肝炎ウイルス(HBV)再活性化の検討
堀田 記世彦, 山田 錬, 森川 賢一, 田邉 起, 坂本 直哉, 篠原 信雄
日本臨床腎移植学会プログラム・抄録集, 55回, 260, 260, (一社)日本臨床腎移植学会, Feb. 2022
Japanese - Kidney transplantation after peritoneal dialysis-associated peritonitis and abdominal abscesses caused by Mycobacterium massiliense: lesson for the clinical nephrologist.
Yasuhiro Ueda, Takayuki Okamoto, Yasuyuki Sato, Asako Hayashi, Toshiyuki Takahashi, Keisuke Kamada, Shohei Honda, Kiyohiko Hotta
Journal of nephrology, 35, 7, 1907, 1910, 04 Jan. 2022, [International Magazine]
English, Scientific journal - [TREATMENT OF BLADDER UROTHELIAL CARCINOMA WITH LUNG METASTASIS AFTER RENAL TRANSPLANTATION].
Tatsu Tanabe, Takahiro Osawa, Kiyohiko Hotta, Daiki Iwami, Hiroshi Kikuchi, Ryuji Matsumoto, Takashige Abe, Nobuo Shinohara
Nihon Hinyokika Gakkai zasshi. The japanese journal of urology, 113, 1, 37, 41, 2022, [Domestic magazines]
Japanese, Scientific journal, We report a case of bladder cancer in a 54-year-old woman who underwent renal transplantation for chronic renal failure. Six years after the transplantation, she was diagnosed with muscle-invasive bladder cancer with multiple lung metastases. She received gemcitabine/cisplatin therapy for Stage IV bladder cancer, and the dose of the immunosuppressants was reduced to prevent adverse effects. Since lung metastatic lesions disappeared after four courses of chemotherapy and no new lesions were found, we performed radical cystectomy and right nephroureterectomy with ileal conduit construction. Although she was followed closely without therapy, multiple lung metastases appeared 6 months after the radical cystectomy. Gemcitabine/carboplatin therapy was administered, and the lung metastasis improved slightly until the end of the 4th course, but aggressive growth was observed after the 5th course. She switched to palliative treatment without requesting additional treatment and died of cancer 1 year and 9 months after total cystectomy.There is no evidence-based treatment strategy for advanced bladder cancer after kidney transplantation. It is necessary to recognize that the patient had renal dysfunction and was in an immunosuppressed state. Thus, it is crucial to select appropriate drug and surgical treatments for each patient. - A Novel Method of CD31-Combined ABO Carbohydrate Antigen Microarray Predicts Acute Antibody-Mediated Rejection in ABO-Incompatible Kidney Transplantation.
Masayuki Tasaki, Hiroaki Tateno, Takashi Sato, Azusa Tomioka, Hiroyuki Kaji, Hisashi Narimatsu, Kazuhide Saito, Yuki Nakagawa, Toshinari Aoki, Masami Kamimura, Takashi Ushiki, Manabu Okada, Yuko Miwa, Kiyohiko Hotta, Yutaka Yoshida, Kota Takahashi, Yoshihiko Tomita
Transplant international : official journal of the European Society for Organ Transplantation, 35, 10248, 10248, 2022, [International Magazine]
English, Scientific journal, Isohemagglutinin assays employing red blood cells (RBCs) are the most common assays used to measure antibody titer in ABO-incompatible kidney transplantation (ABOi KTx). However, ABO antigens expressed on RBCs are not identical to those of kidney and antibody titers do not always correlate with clinical outcome. We previously reported that CD31 was the main protein linked to ABO antigens on kidney endothelial cells (KECs), which was different from those on RBCs. We developed a new method to measure antibody titer using a microarray of recombinant CD31 (rCD31) linked to ABO antigens (CD31-ABO microarray). Mass spectrometry analysis suggested that rCD31 and native CD31 purified from human kidney had similar ABO glycan. To confirm clinical use of CD31-ABO microarray, a total of 252 plasma samples including volunteers, hemodialysis patients, and transplant recipients were examined. In transplant recipients, any initial IgG or IgM antibody intensity >30,000 against the donor blood type in the CD31-ABO microarray showed higher sensitivity, specificity, positive predictive value, and negative predictive value of AABMR, compared to isohemagglutinin assays. Use of a CD31-ABO microarray to determine antibody titer specifically against ABO antigens expressed on KECs will contribute to precisely predicting AABMR or preventing over immunosuppression following ABOi KTx. - Automatic assessment of laparoscopic surgical skill competence based on motion metrics.
Koki Ebina, Takashige Abe, Kiyohiko Hotta, Madoka Higuchi, Jun Furumido, Naoya Iwahara, Masafumi Kon, Kou Miyaji, Sayaka Shibuya, Yan Lingbo, Shunsuke Komizunai, Yo Kurashima, Hiroshi Kikuchi, Ryuji Matsumoto, Takahiro Osawa, Sachiyo Murai, Teppei Tsujita, Kazuya Sase, Xiaoshuai Chen, Atsushi Konno, Nobuo Shinohara
PloS one, 17, 11, e0277105, 2022, [Peer-reviewed], [International Magazine]
English, Scientific journal, The purpose of this study was to characterize the motion features of surgical devices associated with laparoscopic surgical competency and build an automatic skill-credential system in porcine cadaver organ simulation training. Participants performed tissue dissection around the aorta, dividing vascular pedicles after applying Hem-o-lok (tissue dissection task) and parenchymal closure of the kidney (suturing task). Movements of surgical devices were tracked by a motion capture (Mocap) system, and Mocap-metrics were compared according to the level of surgical experience (experts: ≥50 laparoscopic surgeries, intermediates: 10-49, novices: 0-9), using the Kruskal-Wallis test and principal component analysis (PCA). Three machine-learning algorithms: support vector machine (SVM), PCA-SVM, and gradient boosting decision tree (GBDT), were utilized for discrimination of the surgical experience level. The accuracy of each model was evaluated by nested and repeated k-fold cross-validation. A total of 32 experts, 18 intermediates, and 20 novices participated in the present study. PCA revealed that efficiency-related metrics (e.g., path length) significantly contributed to PC 1 in both tasks. Regarding PC 2, speed-related metrics (e.g., velocity, acceleration, jerk) of right-hand devices largely contributed to the tissue dissection task, while those of left-hand devices did in the suturing task. Regarding the three-group discrimination, in the tissue dissection task, the GBDT method was superior to the other methods (median accuracy: 68.6%). In the suturing task, SVM and PCA-SVM methods were superior to the GBDT method (57.4 and 58.4%, respectively). Regarding the two-group discrimination (experts vs. intermediates/novices), the GBDT method resulted in a median accuracy of 72.9% in the tissue dissection task, and, in the suturing task, the PCA-SVM method resulted in a median accuracy of 69.2%. Overall, the mocap-based credential system using machine-learning classifiers provides a correct judgment rate of around 70% (two-group discrimination). Together with motion analysis and wet-lab training, simulation training could be a practical method for objectively assessing the surgical competence of trainees. - CD44 as a pathological marker for the early detection of calcineurin inhibitor-induced nephrotoxicity post kidney transplantation.
Asako Hayashi, Takayuki Okamoto, Junko Nio-Kobayashi, Naoya Iwahara, Ryota Suzuki, Yasuhiro Ueda, Toshiyuki Takahashi, Yasuyuki Sato, Toshihiko Iwanaga, Kiyohiko Hotta
Biomedical research (Tokyo, Japan), 43, 5, 181, 186, 2022, [Domestic magazines]
English, Scientific journal, Long-term calcineurin inhibitor (CNI) administration causes irreversible nephrotoxicity. Therefore, early CNI-induced nephrotoxicity detection is necessary for patients who will need long-term CNI administration. There is no pathological indicator for early CNI-induced nephrotoxicity. Here, serial protocol kidney biopsy specimens from five kidney-transplant patients with severe CNI-induced nephrotoxicity were examined. We observed that the increase in CD44 expression in glomerular parietal epithelial cells (PECs) preceded the chronic pathological changes of CNI-induced nephrotoxicity such as tubular atrophy/interstitial fibrosis, arterial hyaline thickening, and focal segmental glomerulosclerosis (FSGS). This result suggests that CD44-positive PECs have pivotal roles in FSGS development in human CNI-induced nephrotoxicity as well as rodent models. CD44 could be useful as a pathological marker for early CNI-induced nephrotoxicity detection post kidney transplantation. - 腎移植後6年で発症した転移性膀胱癌の治療経験
田邉 起, 大澤 崇宏, 堀田 記世彦, 岩見 大基, 菊地 央, 松本 隆児, 安部 崇重, 篠原 信雄
日本泌尿器科学会雑誌, 113, 1, 37, 41, (一社)日本泌尿器科学会, Jan. 2022
Japanese - 腎移植後6年で発症した転移性膀胱癌の治療経験
田邉 起, 大澤 崇宏, 堀田 記世彦, 岩見 大基, 菊地 央, 松本 隆児, 安部 崇重, 篠原 信雄
日本泌尿器科学会雑誌, 113, 1, 37, 41, (一社)日本泌尿器科学会, Jan. 2022
Japanese - Primary renal leiomyosarcoma with a tumor thrombus in the inferior vena cava.
Mikio Konno, Takahiro Osawa, Kiyohiko Hotta, Ai Shimizu, Takashige Abe, Ryuji Matsumoto, Hiroshi Kikuchi, Nobuo Shinohara
IJU case reports, 5, 1, 66, 69, Jan. 2022, [International Magazine]
English, INTRODUCTION: We report a rare case of primary renal leiomyosarcoma with a tumor thrombus in the inferior vena cava. CASE PRESENTATION: A 54-year-old woman presented with right flank pain and abdominal distension. Physical examination findings were unremarkable. Abdominal computed tomography revealed a heterogeneously enhancing right solid renal mass with a thrombus in the renal vein extending into the inferior vena cava. Magnetic resonance imaging demonstrated a renal tumor with a thrombus about 4 cm below the hepatic vein. Chest computed tomography and bone scintigraphy were negative. The patient underwent right radical nephrectomy and vena cava thrombectomy. Histophathologic evaluation of the resected tumor confirmed the diagnosis of leiomyosarcoma. She underwent no adjuvant therapy. Seven months after surgery, the patient died following a 2-month history of multiple pulmonary and hepatic metastases. CONCLUSION: This report highlights the importance of considering the possibility of renal leiomyosarcoma invasion to the inferior vena cava, similar to renal cell carcinoma. - CASE REPORT: Serial Cases of False-Positive Flow-Cytometry T Cell Crossmatch Associated With Anti-Blood Type Antibodies in Patients Undergoing ABO-Incompatible Kidney Transplantation.
Ayaka Hayashi, Izumi Yamamoto, Mayuko Kawabe, Akimitsu Kobayashi, Makoto Ito, Kiyohiko Hotta, Nobuo Shinohara, Tetsunori Tasaki, Takashi Yokoo, Daiki Iwami
Frontiers in immunology, 13, 862652, 862652, 2022, [International Magazine]
English, Background: A positive flow-cytometry T cell crossmatch (FTXM) has important prognostic implications, even when the complement-dependent cytotoxicity crossmatch is negative. Recent studies have shown that ABO incompatibility is associated with positive FTXM, but the underlying mechanism remains poorly understood. Cases: In five ABO blood type O recipients of kidneys from wives with type B, FTXM was positive but complement-dependent cytotoxicity crossmatch was negative. Application of a solid-phase technique (LABScreen) revealed no case with antibodies to donor-specific human leukocyte antigen. After removal of type B antibodies from patient sera, FTXM was negative for all five patients. In one tested case, the eluate prepared from the donor's T lymphocyte agglutinated only type B red blood cells, implying the existence of blood type B substances on donor T lymphocytes. Discussion: False-positive FTXM reflects blood type B substrates bound to T lymphocytes. Repeat FTXM after incubation with donor-type red blood cells (to adsorb anti-ABO antibodies) was negative. This phenomenon explains the discrepancy between FTXM and solid-phase bead assays. Demonstration of type B substances on donor T lymphocytes is necessary before absolute test validity is confirmed. Conclusion: False-positive FTXM may be associated with type B antibodies bound to T lymphocytes when a blood type O recipient receives tissue from a type B donor. This phenomenon explains the false-positive FTXM observed in the setting of ABO-incompatible kidney transplantation. - Objective evaluation of laparoscopic surgical skills in wet lab training based on motion analysis and machine learning
Koki Ebina, Takashige Abe, Kiyohiko Hotta, Madoka Higuchi, Jun Furumido, Naoya Iwahara, Masafumi Kon, Kou Miyaji, Sayaka Shibuya, Yan Lingbo, Shunsuke Komizunai, Yo Kurashima, Hiroshi Kikuchi, Ryuji Matsumoto, Takahiro Osawa, Sachiyo Murai, Teppei Tsujita, Kazuya Sase, Xiaoshuai Chen, Atsushi Konno, Nobuo Shinohara
Langenbeck's Archives of Surgery, 2022
Scientific journal - 腎移植における慢性活動性抗体関連型拒絶反応早期診断のための混合リンパ球反応試験の開発
岩原 直也, 堀田 記世彦, 田邉 起, 高田 祐輔, 樋口 はるか, 佐々木 元, 原田 浩, 広瀬 貴行, 岩見 大基, 篠原 信雄
日本泌尿器科学会総会, 109回, AOP13, 07, (一社)日本泌尿器科学会総会事務局, Dec. 2021
Japanese - 生体腎移植ドナーの長期生命予後と腎機能推移の検討
堀田 記世彦, 大澤 崇宏, 横田 勲, 稲尾 翼, 田邉 起, 岩原 直也, 篠原 信雄
日本泌尿器科学会総会, 109回, OP56, 07, (一社)日本泌尿器科学会総会事務局, Dec. 2021
Japanese - 腎移植における慢性活動性抗体関連型拒絶反応早期診断のための混合リンパ球反応試験の開発
岩原 直也, 堀田 記世彦, 田邉 起, 高田 祐輔, 樋口 はるか, 佐々木 元, 原田 浩, 広瀬 貴行, 岩見 大基, 篠原 信雄
日本泌尿器科学会総会, 109回, AOP13, 07, (一社)日本泌尿器科学会総会事務局, Dec. 2021
Japanese - Novel double-filtration plasmapheresis preserves fibrinogen while removing immunoglobulin-G antibodies before ABO blood type-incompatible kidney transplantation
Daiki Iwami, Takenao Matsumoto, Kota Ono, Kiyohiko Hotta, Minoru Ota, Yuki Chiba, Hajime Sasaki, Takayuki Hirose, Haruka Higuchi, Yusuke Takada, Naoya Iwahara, Sachiyo Murai, Nobuo Shinohara
Renal Replacement Therapy, 7, 1, Dec. 2021
Scientific journal - 生体腎移植ドナーの長期生命予後と腎機能推移の検討
堀田 記世彦, 大澤 崇宏, 横田 勲, 稲尾 翼, 田邉 起, 岩原 直也, 篠原 信雄
日本泌尿器科学会総会, 109回, OP56, 07, (一社)日本泌尿器科学会総会事務局, Dec. 2021
Japanese - 篤志献体を用いた腹腔鏡下根治的腎摘除術トレーニングの経験
安部 崇重, 今 雅史, 岩原 直也, 古御堂 純, 樋口 まどか, 菊地 央, 堀田 記世彦, 松本 隆児, 大澤 崇宏, 篠原 信雄
日本泌尿器内視鏡学会総会, 35回, V, 5, (一社)日本泌尿器内視鏡・ロボティクス学会, Nov. 2021
Japanese - 篤志献体を用いた腹腔鏡下根治的腎摘除術トレーニングの経験
安部 崇重, 今 雅史, 岩原 直也, 古御堂 純, 樋口 まどか, 菊地 央, 堀田 記世彦, 松本 隆児, 大澤 崇宏, 篠原 信雄
日本泌尿器内視鏡学会総会, 35回, V, 5, (一社)日本泌尿器内視鏡・ロボティクス学会, Nov. 2021
Japanese - 生体腎移植ドナーの腎機能と透析導入リスク 生体腎移植ドナーの長期生命予後と腎機能推移の検討
堀田 記世彦, 大澤 崇宏, 横田 勲, 稲尾 翼, 田邉 起, 岩原 直也, 篠原 信雄
移植, 56, 総会臨時, SSY2, 4, (一社)日本移植学会, Sep. 2021
Japanese - 生体腎移植ドナーの腎機能と透析導入リスク 生体腎移植ドナーの長期生命予後と腎機能推移の検討
堀田 記世彦, 大澤 崇宏, 横田 勲, 稲尾 翼, 田邉 起, 岩原 直也, 篠原 信雄
移植, 56, 総会臨時, SSY2, 4, (一社)日本移植学会, Sep. 2021
Japanese - Correction to: Motion analysis for better understanding of psychomotor skills in laparoscopy: objective assessment-based simulation training using animal organs.
Koki Ebina, Takashige Abe, Madoka Higuchi, Jun Furumido, Naoya Iwahara, Masafumi Kon, Kiyohiko Hotta, Shunsuke Komizunai, Yo Kurashima, Hiroshi Kikuchi, Ryuji Matsumoto, Takahiro Osawa, Sachiyo Murai, Teppei Tsujita, Kazuya Sase, Xiaoshuai Chen, Atsushi Konno, Nobuo Shinohara
Surgical endoscopy, 35, 8, 4417, 4417, Aug. 2021, [International Magazine]
English - Motion analysis for better understanding of psychomotor skills in laparoscopy: objective assessment-based simulation training using animal organs.
Koki Ebina, Takashige Abe, Madoka Higuchi, Jun Furumido, Naoya Iwahara, Masafumi Kon, Kiyohiko Hotta, Shunsuke Komizunai, Yo Kurashima, Hiroshi Kikuchi, Ryuji Matsumoto, Takahiro Osawa, Sachiyo Murai, Teppei Tsujita, Kazuya Sase, Xiaoshuai Chen, Atsushi Konno, Nobuo Shinohara
Surgical endoscopy, 35, 8, 4399, 4416, Aug. 2021, [International Magazine]
English, Scientific journal, BACKGROUND: Our aim was to characterize the motions of multiple laparoscopic surgical instruments among participants with different levels of surgical experience in a series of wet-lab training drills, in which participants need to perform a range of surgical procedures including grasping tissue, tissue traction and dissection, applying a Hem-o-lok clip, and suturing/knotting, and digitize the level of surgical competency. METHODS: Participants performed tissue dissection around the aorta, dividing encountered vessels after applying a Hem-o-lok (Task 1), and renal parenchymal closure (Task 2: suturing, Task 3: suturing and knot-tying), using swine cadaveric organs placed in a box trainer under a motion capture (Mocap) system. Motion-related metrics were compared according to participants' level of surgical experience (experts: 50 ≤ laparoscopic surgeries, intermediates: 10-49, novices: 0-9), using the Kruskal-Wallis test, and significant metrics were subjected to principal component analysis (PCA). RESULTS: A total of 15 experts, 12 intermediates, and 18 novices participated in the training. In Task 1, a shorter path length and faster velocity/acceleration/jerk were observed using both scissors and a Hem-o-lok applier in the experts, and Hem-o-lok-related metrics markedly contributed to the 1st principal component on PCA analysis, followed by scissors-related metrics. Higher-level skills including a shorter path length and faster velocity were observed in both hands of the experts also in tasks 2 and 3. Sub-analysis showed that, in experts with 100 ≤ cases, scissors moved more frequently in the "close zone (0 ≤ to < 2.0 cm from aorta)" than those with 50-99 cases. CONCLUSION: Our novel Mocap system recognized significant differences in several metrics in multiple instruments according to the level of surgical experience. "Applying a Hem-o-lok clip on a pedicle" strongly reflected the level of surgical experience, and zone-metrics may be a promising tool to assess surgical expertise. Our next challenge is to give completely objective feedback to trainees on-site in the wet-lab. - Response to steroid and immunosuppressive therapies may predict post-transplant recurrence of steroid-resistant nephrotic syndrome.
Kenichiro Miura, Taro Ando, Shoichiro Kanda, Taeko Hashimoto, Naoto Kaneko, Kiyonobu Ishizuka, Riku Hamada, Hiroshi Hataya, Kiyohiko Hotta, Yoshimitsu Gotoh, Kei Nishiyama, Yuko Hamasaki, Seiichiro Shishido, Naoya Fujita, Motoshi Hattori
Pediatric transplantation, e14103, 26 Jul. 2021, [International Magazine]
English, Scientific journal, BACKGROUND: Recurrence of SRNS is a major challenge in KT. Several clinical factors, including initial steroid sensitivity, have been associated with increased post-transplant SRNS recurrence risk. However, conflicting data have been reported, possibly due to the heterogeneous pathophysiology of SRNS and the lack of genetic testing of SRNS patients. Furthermore, the response to immunosuppressive therapies has not been evaluated. METHODS: Seventy patients aged 1-15 years at SRNS onset who underwent KT between 2002 and 2018 were enrolled. Patients with secondary, familial, syndromic, and genetic forms of SRNS and those who were not treated with steroid were excluded. This study aimed to assess the risk factors for post-transplant recurrence, including treatment responses to initial steroid therapy and additional therapies with immunosuppressive agents, rituximab, plasmapheresis, and/or LDL-A. RESULTS: Data from 36 kidney transplant recipients were analyzed. Twenty-two (61%) patients experienced post-transplant SRNS recurrence, while 14 patients did not. The proportion of patients who achieved complete or partial remission with initial steroid therapy and/or additional therapies with immunosuppressive agents, rituximab, plasmapheresis, and/or LDL-A was significantly higher in the SRNS recurrence group (19/22, 86%) than in the group without SRNS recurrence (6/14, 43%; p = .01). CONCLUSION: This study suggests that the response to steroid treatment, other immunosuppressive agents, rituximab, plasmapheresis, and/or LDL-A may predict post-transplant SRNS recurrence. - A case report of percutaneous direct injection of N-butyl-2-cyanoacrylate (NBCA) to treat a pancreatic duodenal stump leak after a simultaneous pancreas and kidney transplantation.
Chisato Shirakawa, Masaaki Watanabe, Tsuyoshi Shimamura, Yasuyuki Koshizuka, Norio Kawamura, Ryoichi Goto, Takeshi Soyama, Daiki Iwami, Kiyohiko Hotta, Akinobu Taketomi, Daisuke Abo
Surgical case reports, 7, 1, 139, 139, 08 Jun. 2021, [International Magazine]
English, Scientific journal, BACKGROUND: Simultaneous pancreas and kidney transplantation (SPK) is a treatment option for patients with end-stage renal disease due to type 1 diabetes mellitus. We report a patient with a refractory fistula due to leakage from the duodenal stump of the pancreas graft after an SPK with bladder drainage who was successfully treated with a percutaneous direct injection of N-butyl-2-cyanoacrylate (NBCA). CASE PRESENTATION: A 60-year-old female with a 33-year history of type 1 diabetes mellitus and a 10-year history of renal replacement therapy underwent an SPK in 2015. At the time of transplantation, an abdominal aortic aneurysm with a high risk of rupture was treated by a Y-graft replacement prior to the SPK. Bladder drainage of the pancreas graft was chosen to avoid a vessel graft infection. The patient's postoperative course was uneventful. The patient was discharged on postoperative day 93 with good-functioning pancreas and kidney grafts. One and a half years after the operation, the patient was found to have acute graft pancreatitis and a leak from the duodenal stump of the pancreas graft due to a paralytic neurogenic bladder. The insertion of an indwelling catheter into the bladder and the endoscopic-guided insertion of a catheter into the graft pancreatic duct through the duodenum/bladder anastomosis did not result in the closure of the fistula. Therefore, NBCA was injected at the site of the leak point using CT-guided technique. The fistula was completely closed immediately after the injection, with no recurrences of leaks. CONCLUSIONS: A percutaneous direct injection of NBCA is one of the treatment options to treat intractable fistulas. - Spontaneous closure of arteriovenous fistula after kidney transplantation.
Tatsu Tanabe, Kiyohiko Hotta, Naoya Iwahara, Daiki Iwami, Sachiyo Murai, Nobuo Shinohara
International journal of urology : official journal of the Japanese Urological Association, 28, 8, 872, 873, 19 May 2021, [International Magazine]
English, Scientific journal - 肝腎症候群による腎不全併発非代償性肝硬変症例に対する、脳死肝単独と、脳死肝腎同時移植症例の比較検討
伊藤 栄祐, 渡辺 正明, 渋谷 一陽, 巖築 慶一, 川村 典生, 後藤 了一, 堀田 記世彦, 篠原 信雄, 嶋村 剛, 武冨 紹信
日本外科学会定期学術集会抄録集, 121回, RS, 6, (一社)日本外科学会, Apr. 2021
Japanese - Long-Term Outcome of ABO-Incompatible Kidney Transplantation in Patients Treated With Low-Dose Rituximab Regimen.
Hajime Sasaki, Kiyohiko Hotta, Akihiko Mitsuke, Yuichiro Fukasawa, Tatsu Tanabe, Haruka Higuchi, Yusuke Takada, Hiroshi Harada
Transplantation proceedings, 53, 3, 989, 994, Apr. 2021, [International Magazine]
English, Scientific journal, BACKGROUND: Introduction of rituximab in the desensitization protocols for ABO-incompatible (ABOI) kidney transplantation (KTX) has afforded excellent results. However, the acceptability of minimal dosage of rituximab in these protocols remains to be defined. METHODS: Sixty-three patients who underwent ABOI KTX were included in this study. The desensitization protocol consisted of plasmapheresis, tacrolimus, mycophenolate mofetil, methylprednisolone, intravenous immunoglobulin, basiliximab, and low-dose rituximab (100 mg/body). We evaluated the efficacy, safety, and long-term outcome of this protocol (group R, n = 39) and compared them with those of patients who underwent splenectomy (group S, n = 24). RESULTS: Graft and patient survival at 10 years after KTX were comparable between the groups (94.4% [group R] vs 95.4% [group S] and 94.6% [group R] vs 95.8% [group S], respectively). The incidence of acute antibody-mediated rejection (AAMR) was similar in the 2 groups (10.2% vs 12.5%). There were no significant differences in the incidence of chronic active antibody-mediated rejection. Of the patients, 7 developed AAMR and 3 of these patients (1 in group R and 2 in group S) lost their grafts. There were no significant differences in the incidence of chronic active antibody-mediated rejection. The incidence of postoperative cytomegalovirus infection in group R was significantly lower than that in group S. Furthermore, the incidence of postoperative late-onset neutropenia was low in group R. CONCLUSIONS: A low-dose rituximab regimen for ABOI KTX is acceptable for preventing AAMR with a low incidence of delayed adverse events. - 尿管動脈瘻に対して血管内治療を行なった1例
杉戸 悠紀, 山田 修平, 千葉 博基, 堀田 記世彦, 木野田 直也, 森田 亮, 阿保 大介, 篠原 信雄
泌尿器外科, 34, 3, 322, 322, 医学図書出版(株), Mar. 2021
Japanese - 生体腎移植後に大腿神経麻痺を来した1例
山田 修平, 堀田 記世彦, 岩見 大基, 高畑 雅彦, 杉戸 悠紀, 篠原 信雄
泌尿器外科, 34, 3, 325, 325, 医学図書出版(株), Mar. 2021
Japanese - ステロイドによるカルシニューリン阻害剤腎毒性進行抑制効果の検討
岩原 直也, 堀田 記世彦, 田邉 起, 高田 祐輔, 樋口 はるか, 佐々木 元, 岩見 大基, 篠原 信雄
泌尿器外科, 34, 3, 332, 332, 医学図書出版(株), Mar. 2021
Japanese - 後腹膜脂肪肉腫再発に対し自家腎移植による尿路再建を行った1例
岩原 直也, 堀田 記世彦, 岩見 大基, 松本 隆児, 大澤 崇宏, 安部 崇重, 篠原 信雄
泌尿器外科, 34, 3, 315, 315, 医学図書出版(株), Mar. 2021
Japanese - TURBT時の死冠(corona mortis)損傷による致命的な出血性ショックに対してTAEにて救命し得た1例
黒沢 瞭, 堀田 記世彦, 阿保 大介, 岩見 大基, 安部 崇重, 田邉 起, 大澤 崇宏, 松本 隆児, 篠原 信雄
泌尿器外科, 34, 3, 331, 331, 医学図書出版(株), Mar. 2021
Japanese - 尿管動脈瘻に対して血管内治療を行なった1例
杉戸 悠紀, 山田 修平, 千葉 博基, 堀田 記世彦, 木野田 直也, 森田 亮, 阿保 大介, 篠原 信雄
泌尿器外科, 34, 3, 322, 322, 医学図書出版(株), Mar. 2021
Japanese - 肝腎症候群を併発した非代償性肝硬変に対する脳死肝腎同時移植
堀田 記世彦, 渡辺 正明, 川村 典生, 後藤 了一, 田邉 起, 嶋村 剛, 篠原 信雄, 武富 紹信
日本臨床腎移植学会プログラム・抄録集, 54回, 134, 134, (一社)日本臨床腎移植学会, Feb. 2021
Japanese - 肝腎症候群を併発した非代償性肝硬変に対する脳死肝腎同時移植
堀田 記世彦, 渡辺 正明, 川村 典生, 後藤 了一, 田邉 起, 嶋村 剛, 篠原 信雄, 武富 紹信
日本臨床腎移植学会プログラム・抄録集, 54回, 134, 134, (一社)日本臨床腎移植学会, Feb. 2021
Japanese - Successful kidney transplantation in a patient with neonatal-onset ILNEB.
Takayuki Okamoto, Akie Nakamura, Asako Hayashi, Takeshi Yamaguchi, Yayoi Ogawa, Ken Natsuga, Kumiko Yanagi, Kiyohiko Hotta
Pediatric transplantation, 25, 5, e13971, 20 Jan. 2021, [International Magazine]
English, BACKGROUND: ILNEB constitute an autosomal recessive disorder caused by homozygous or compound heterozygous mutation of the gene for the ITGA3. To date, 8 ILNEB patients have been reported, but all 6 neonatal-onset ILNEB patients suffered early death within 2 years. The most common cause of death among previously reported ILNEB patients was exacerbation of the respiratory condition. METHODS: In this study, we describe a case of ILNEB with neonatal onset in a female patient and the genetic and histopathological testing performed. RESULTS: Our patient had a compound heterozygous mutation in ITGA3. Compared to previously reported patients, this patient exhibited milder clinical and histopathological characteristics. After experiencing a life-threatening respiratory infection at 8 months old, the patient started periodic subcutaneous immunoglobulin treatment once every 1-2 weeks for nephrotic-range proteinuria-induced secondary hypogammaglobulinemia. At the age of 3 years, proteinuria gradually increased with severe edema despite strict internal management. Therefore, our patient underwent unilateral nephrectomy and insertion of a peritoneal dialysis catheter followed by another unilateral nephrectomy. One month later, she underwent an ABO-compatible living-donor kidney transplantation at the age of 4 years. CONCLUSIONS: Our patient is a neonatal-onset ILNEB patient who survived for more than 2 years and underwent successful kidney transplantation. - 腎移植後慢性拒絶反応診断のためのLiquid Biopsy 炎症回路に関わる新規尿中バイオマーカーの研究
高田 祐輔, 上村 大輔, 樋口 はるか, 岩見 大基, 堀田 記世彦, 岩原 直也, 篠原 信雄, 村上 正晃
日本泌尿器科学会総会, 108回, 872, 872, (一社)日本泌尿器科学会総会事務局, Dec. 2020
Japanese - 原発性胆汁性胆管炎による非代償性肝硬変、腎不全に対し脳死下肝腎同時移植を実施した一例
山本 啓一朗, 後藤 了一, 深澤 拓夢, 巖築 慶一, 川村 典生, 渡辺 正明, 小川 浩司, 堀田 記世彦, 岩見 大基, 篠原 信雄, 嶋村 剛, 武冨 紹信
北海道外科雑誌, 65, 2, 158, 163, 北海道外科学会, Dec. 2020
Japanese - モーションキャプチャー装置を用いた腹腔鏡手術手技の熟練過程の分析
安部 崇重, 海老名 光希, 樋口 まどか, 古御堂 純, 岩原 直也, 今 雅史, 堀田 記世彦, 小水内 俊介, 倉島 庸, 村井 祥代, 近野 敦, 篠原 信雄
日本泌尿器科学会総会, 108回, 899, 899, (一社)日本泌尿器科学会総会事務局, Dec. 2020
Japanese - 原発性胆汁性胆管炎による非代償性肝硬変、腎不全に対し脳死下肝腎同時移植を実施した一例
山本 啓一朗, 後藤 了一, 深澤 拓夢, 巖築 慶一, 川村 典生, 渡辺 正明, 小川 浩司, 堀田 記世彦, 岩見 大基, 篠原 信雄, 嶋村 剛, 武冨 紹信
北海道外科雑誌, 65, 2, 158, 163, 北海道外科学会, Dec. 2020
Japanese - Femoral nerve palsy following kidney transplantation: A case report and review of the literature.
Shuhei Yamada, Kiyohiko Hotta, Masahiko Takahata, Daiki Iwami, Yuki Sugito, Tatsu Tanabe, Naoya Iwahara, Nobuo Shinohara
IJU case reports, 3, 6, 248, 251, Nov. 2020, [International Magazine]
English, Introduction: Femoral nerve palsy is a rare but serious complication of kidney transplantation. We report a case of femoral nerve palsy following kidney transplantation and conduct a review of the literature on this complication. Case presentation: A 35-year-old woman with end-stage kidney disease, underwent kidney transplantation in the right iliac fossa. The day after the transplantation, she could not straighten her right leg. Physical examination revealed a paresis of her right quadriceps muscle. The patient's sensation of her right thigh was also impaired. We diagnosed her with femoral nerve palsy caused by inappropriate compression from a self-retaining retractor. Rehabilitation was started immediately. The patient's motor weakness gradually improved, and the patient became able to walk independently 4 weeks later. However, the patient's neuropathic pain sustained 6 months after her kidney transplantation. Conclusion: The improper use of self-retaining retractors can lead to femoral nerve palsy in patients undergoing kidney transplantation. - 腎移植時における多発性嚢胞腎に対する鏡視下後腹膜アプローチ自己腎摘術
堀田 記世彦, 岩見 大基, 田邉 起, 岩原 直也, 篠原 信雄
移植, 55, 総会臨時, 249, 249, (一社)日本移植学会, Oct. 2020
Japanese - 低抗体価のABO血液型不適合腎移植に対して術前血漿交換は必要か
田邉 起, 堀田 記世彦, 岩原 直也, 岩見 大基, 篠原 信雄
移植, 55, 総会臨時, 309, 309, (一社)日本移植学会, Oct. 2020
Japanese - 腎移植後慢性拒絶反応のためのLiquid Biopsy 尿中エクソソームSYT17(Synaptotagmin 17)の有用性
高田 祐輔, 上村 大輔, 樋口 はるか, 岩見 大基, 堀田 記世彦, 岩原 直也, 篠原 信雄, 村上 正晃
移植, 55, 総会臨時, 339, 339, (一社)日本移植学会, Oct. 2020
Japanese - 安定した腎移植患者はドナー特異的に免疫反応が抑制される
岩原 直也, 堀田 記世彦, 田邉 起, 岩見 大基, 篠原 信雄
移植, 55, 総会臨時, 381, 381, (一社)日本移植学会, Oct. 2020
Japanese - 腎移植時における多発性嚢胞腎に対する鏡視下後腹膜アプローチ腎摘術
堀田 記世彦, 岩見 大基, 古御堂 純, 岩原 直也, 篠原 信雄
日本透析医学会雑誌, 53, Suppl.1, 812, 812, (一社)日本透析医学会, Oct. 2020
Japanese - Development and validation of a porcine organ model for training in essential laparoscopic surgical skills.
Madoka Higuchi, Takashige Abe, Kiyohiko Hotta, Ken Morita, Haruka Miyata, Jun Furumido, Naoya Iwahara, Masafumi Kon, Takahiro Osawa, Ryuji Matsumoto, Hiroshi Kikuchi, Yo Kurashima, Sachiyo Murai, Abdullatif Aydin, Nicholas Raison, Kamran Ahmed, Muhammad Shamim Khan, Prokar Dasgupta, Nobuo Shinohara
International journal of urology : official journal of the Japanese Urological Association, 27, 10, 929, 938, Oct. 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal, OBJECTIVES: To develop a wet laboratory training model for learning core laparoscopic surgical skills and evaluating learners' competency level outside the operating room. METHODS: Participants completed three tasks (task 1: tissue dissection around the aorta; task 2: tissue dissection and division of the renal artery; task 3: renal parenchymal closure). Each performance was video recorded and subsequently evaluated by two experts, according to the Global Operative Assessment of Laparoscopic Skills and task-specific metrics that we developed (Assessment Sheet of Laparoscopic Skills in Wet Lab score). Mean scores were used for analyses. The subjective mental workload was also assessed (NASA Task Load Index). RESULTS: The 54 participants included 32 urologists, eight young trainees and 14 medical students. A total of 13 participants were categorized as experts (≥50 laparoscopic surgeries), eight as intermediates (10-49) and 33 as novices (0-9). There were significant differences in the Global Operative Assessment of Laparoscopic Skills and Assessment Sheet of Laparoscopic Skills in Wet Lab scores among the three groups in all three tasks. Higher NASA Task Load Index scores were observed in novices, and there were significant differences in tasks 1 (Kruskal-Wallis test, P = 0.0004) and 2 (P = 0.0002), and marginal differences in task 3 (P = 0.0745) among the three groups. CONCLUSIONS: Our training model has good construct validity, and differences in the NASA Task Load Index score reflect previous laparoscopic surgical experiences. Our findings show the ability to assess both laparoscopic surgical skills and mental workloads, which could help educators comprehend trainees' level outside the operating room. Given the decreasing opportunity to carry out pure laparoscopic surgeries because of the dissemination of robotic surgery, especially in urology, our model can offer practical training opportunities. - Increased urinary exosomal SYT17 levels in chronic active antibody-mediated rejection after kidney transplantation via the IL-6 amplifier.
Yusuke Takada, Daisuke Kamimura, Jing-Jing Jiang, Haruka Higuchi, Daiki Iwami, Kiyohiko Hotta, Yuki Tanaka, Mitsutoshi Ota, Madoka Higuchi, Saori Nishio, Tatsuya Atsumi, Nobuo Shinohara, Yoshihiro Matsuno, Takahiro Tsuji, Tatsu Tanabe, Hajime Sasaki, Naoya Iwahara, Masaaki Murakami
International immunology, 32, 10, 653, 662, 30 Sep. 2020, [International Magazine]
English, Scientific journal, Chronic active antibody-mediated rejection (CAAMR) is a particular problem in kidney transplantation (KTx), and ~25% of grafts are lost by CAAMR. Further, the pathogenesis remains unclear, and there is no effective cure or marker. We previously found that a hyper NFκB-activating mechanism in non-immune cells, called the IL-6 amplifier, is induced by the co-activation of NFκB and STAT3, and that this activation can develop various chronic inflammatory diseases. Here, we show that synaptotagmin-17 (SYT17) is increased in an exosomal fraction of the urine from CAAMR patients, and that this increase is associated with activation of the IL-6 amplifier. Immunohistochemistry showed that SYT17 protein expression was increased in renal tubule cells of the CAAMR group. While SYT17 protein was not detectable in whole-urine samples by western blotting, urinary exosomal SYT17 levels were significantly elevated in the CAAMR group compared to three other histology groups (normal, interstitial fibrosis and tubular atrophy, and calcineurin inhibitors toxicity) after KTx. On the other hand, current clinical laboratory data could not differentiate the CAAMR group from these groups. These data suggest that urinary exosomal SYT17 is a potential diagnostic marker for CAAMR. - 肝腎症候群による腎不全を伴った原発性胆汁性胆管炎、非代償性肝硬変に対し脳死肝移植を施行した3例の検討
鈴木 大喜, 後藤 了一, 巖築 慶一, 川村 典生, 渡辺 正明, 山本 啓一朗, 深澤 拓夢, 堀田 記世彦, 岩見 大基, 篠原 信雄, 嶋村 剛, 武冨 紹信
日本外科学会定期学術集会抄録集, 120回, RS, 10, (一社)日本外科学会, Aug. 2020
Japanese - 肝腎症候群による腎不全を伴った原発性胆汁性胆管炎、非代償性肝硬変に対し脳死肝移植を施行した3例の検討
鈴木 大喜, 後藤 了一, 巖築 慶一, 川村 典生, 渡辺 正明, 山本 啓一朗, 深澤 拓夢, 堀田 記世彦, 岩見 大基, 篠原 信雄, 嶋村 剛, 武冨 紹信
日本外科学会定期学術集会抄録集, 120回, RS, 10, (一社)日本外科学会, Aug. 2020
Japanese - 尿中エクソソームおよび微小嚢胞中のmRNA測定による移植腎機能障害の診断法の開発および全国症例解析によるValidation
原田 浩, 福澤 信之, 阿部 豊文, 今村 亮一, 正木 紀行, 藤山 信弘, 佐藤 滋, 畠山 真吾, 西村 憲二, 岸川 英史, 岩見 大基, 堀田 記世彦, 三浦 正義, 井手 健太郎, 中村 道郎, 香束 昌宏, 内田 潤次, 村上 卓, 辻 隆裕
日本臨床腎移植学会雑誌, 8, 1, 142, 150, (一社)日本臨床腎移植学会, Jul. 2020
Japanese - 尿中エクソソームおよび微小嚢胞中のmRNA測定による移植腎機能障害の診断法の開発および全国症例解析によるValidation
原田 浩, 福澤 信之, 阿部 豊文, 今村 亮一, 正木 紀行, 藤山 信弘, 佐藤 滋, 畠山 真吾, 西村 憲二, 岸川 英史, 岩見 大基, 堀田 記世彦, 三浦 正義, 井手 健太郎, 中村 道郎, 香束 昌宏, 内田 潤次, 村上 卓, 辻 隆裕
日本臨床腎移植学会雑誌, 8, 1, 142, 150, (一社)日本臨床腎移植学会, Jul. 2020
Japanese - Corrigendum: Orosomucoid 1 is involved in the development of chronic allograft rejection after kidney transplantation.
Haruka Higuchi, Daisuke Kamimura, Jing-Jing Jiang, Toru Atsumi, Daiki Iwami, Kiyohiko Hotta, Hiroshi Harada, Yusuke Takada, Hiromi Kanno-Okada, Kanako C Hatanaka, Yuki Tanaka, Nobuo Shinohara, Masaaki Murakami
International immunology, 32, 7, 493, 493, 26 Jun. 2020, [International Magazine]
English, Scientific journal - Kidney function of Japanese children undergoing kidney transplant with preemptive therapy for cytomegalovirus infection.
Yoshimitsu Gotoh, Seiichiro Shishido, Yuko Hamasaki, Yoshihiko Watarai, Motoshi Hattori, Kenichiro Miura, Kiyonobu Ishizuka, Naoya Fujita, Kazuhide Saito, Yuki Nakagawa, Kiyohiko Hotta, Hiroshi Hataya, Riku Hamada, Hiroyuki Sato, Hirotsugu Kitayama, Kenji Ishikura, Masataka Honda, Osamu Uemura
Transplant infectious disease : an official journal of the Transplantation Society, 22, 3, e13271, Jun. 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: Cytomegalovirus (CMV) infection is one of the major factors that affect morbidity and mortality in kidney transplant (KTx) patients. The rate of CMV seropositivity in children before KTx is lower than that in adults; therefore, pediatric KTx patients have a higher risk of CMV infection. In Japanese pediatric KTx patients, preemptive therapy for CMV infection is a main conventional therapy. This study investigated whether this preemptive treatment would affect kidney function at 2 years post-KTx. METHODS: A total of 163 patients, that is approximately half of the Japanese pediatric KTx patients nationwide, were recruited to participate in our study. We compared the values of the sequential estimated glomerular filtration rate (eGFR) at two years post-KTx and other influencing factors in CMV viremia, CMV disease, and no-infection groups. RESULTS: Cytomegalovirus infection after KTx occurred in 75 patients (46.0%), 38.7% of whom developed CMV disease. The sequential eGFR values post-KTx did not differ significantly between the three groups. CMV infection was not significantly correlated with other factors, other infections (including Epstein-Barr [EB] virus infection), acute rejection (AR), or adverse events. Only prolonged duration of total hospitalization was significantly associated with CMV infection (P = .002). In the multivariate analysis, younger age, CMV infection, and adverse effects were independently significantly related to prolonged total hospitalization. CONCLUSION: Preemptive therapy for CMV infection evidenced by viremia and disease did not significantly influence kidney function in Japanese pediatric KTx patients at two years after the operation. - Orosomucoid 1 is involved in the development of chronic allograft rejection after kidney transplantation.
Haruka Higuchi, Daisuke Kamimura, Jing-Jing Jiang, Toru Atsumi, Daiki Iwami, Kiyohiko Hotta, Hiroshi Harada, Yusuke Takada, Hiromi Kanno-Okada, Kanako C Hatanaka, Yuki Tanaka, Nobuo Shinohara, Masaaki Murakami
International immunology, 32, 5, 335, 346, 08 May 2020, [Peer-reviewed], [International Magazine]
English, Scientific journal, Chronic allograft rejection is the most common cause of long-term allograft failure. One reason is that current diagnostics and therapeutics for chronic allograft rejection are very limited. We here show that enhanced NFκB signaling in kidney grafts contributes to chronic active antibody-mediated rejection (CAAMR), which is a major pathology of chronic kidney allograft rejections. Moreover, we found that urinary orosomucoid 1 (ORM1) is a candidate marker molecule and therapeutic target for CAAMR. Indeed, urinary ORM1 concentration was significantly higher in kidney transplant recipients pathologically diagnosed with CAAMR than in kidney transplant recipients with normal histology, calcineurin inhibitor toxicity, or interstitial fibrosis and tubular atrophy. Additionally, we found that kidney biopsy samples with CAAMR expressed more ORM1 and had higher NFκB and STAT3 activation in tubular cells than samples from non-CAAMR samples. Consistently, ORM1 production was induced after cytokine-mediated NFκB and STAT3 activation in primary kidney tubular cells. The loss- and gain-of-function of ORM1 suppressed and promoted NFκB activation, respectively. Finally, ORM1-enhanced NFκB-mediated inflammation development in vivo. These results suggest that an enhanced NFκB-dependent pathway following NFκB and STAT3 activation in the grafts is involved in the development of chronic allograft rejection after kidney transplantation and that ORM1 is a non-invasive candidate biomarker and possible therapeutic target for chronic kidney allograft rejection. - 原発性胆汁性胆管炎の非代償性肝硬変、腎不全に対し脳死下肝腎同時移植を実施した一例
山本 啓一朗, 後藤 了一, 深澤 拓夢, 巖築 慶一, 川村 典生, 渡辺 正明, 堀田 記世彦, 岩見 大基, 篠原 信雄, 嶋村 剛, 武冨 紹信
日本臨床外科学会雑誌, 81, 4, 799, 799, 日本臨床外科学会, Apr. 2020
Japanese - RTC・移植医のパートナーシップで腎移植〜知ってた?!お互い悩んでいること〜 PEKTについてRTCが重要と考えること
高田 めぐみ, 山本 真由美, 中野 政子, 岩見 大基, 堀田 記世彦
日本臨床腎移植学会プログラム・抄録集, 53回, 156, 156, (一社)日本臨床腎移植学会, Feb. 2020
Japanese - 後腹膜鏡下移植用腎採取術の提供側による腎移植成績への影響
岩見 大基, 堀田 記世彦, 篠原 信雄
日本臨床腎移植学会プログラム・抄録集, 53回, 210, 210, (一社)日本臨床腎移植学会, Feb. 2020
Japanese - ANCA陰性化の後に生体腎移植を施行したANCA関連血管炎の一例
前田 啓介, 堀田 記世彦, 岩見 大基, 岩原 直也, 平田 由里絵, 篠原 信雄
日本臨床腎移植学会プログラム・抄録集, 53回, 265, 265, (一社)日本臨床腎移植学会, Feb. 2020
Japanese - Validity assessment of the laparoscopic radical nephrectomy module of the LapVision virtual reality simulator.
Haruka Miyata, Takashige Abe, Kiyohiko Hotta, Madoka Higuchi, Takahiro Osawa, Ryuji Matsumoto, Hiroshi Kikuchi, Yo Kurashima, Sachiyo Murai, Nobuo Shinohara
Surgery open science, 2, 1, 51, 56, Jan. 2020, [International Magazine]
English, Scientific journal, Background: Virtual reality simulators allow trainees to perform repeated practice and provide objective dexterity metrics regarding their performance, which means that virtual reality-based surgical training is becoming a vital part of initial learning of basic laparoscopic surgical skills. However, its educational role in learning advanced procedures remains undetermined. We evaluated the validity of the laparoscopic radical nephrectomy module of the LapVision virtual reality simulator. Methods: Urologists, medical students, and a junior resident voluntarily participated in the present study, and they performed training with a laparoscopic left radical nephrectomy module. For construct validation, dexterity metrics calculated in the simulator and the mean score of Global Operative Assessment of Laparoscopic Skills evaluated by 2 experts' video review were compared according to the certification of Japanese Endoscopic Surgical Skill Qualification or previous surgical experience. Results: Ten experts (≥ 50 laparoscopic surgeries), 9 intermediates (11-49), and 14 novices (0-10) voluntarily participated in the present study. Regarding the construct validity, there was a significant difference in the total number of errors, blood loss, and Global Operative Assessment of Laparoscopic Skills score among the groups for both the Endoscopic Surgical Skill Qualification status and previous surgical experience. Conclusion: The present study demonstrated good construct validity for the LapVision nephrectomy module. Furthermore, global skill assessment was possible by experts' reviews, which indicates the usefulness of the virtual reality procedural module as a skill assessment tool. Virtual reality-based procedural simulation has marked potential to become a vital part of integrated laparoscopic training programs. - Editorial Comment to Analysis of the prevalence of systemic de novo thrombotic microangiopathy after ABO-incompatible kidney transplantation and the associated risk factors.
Kiyohiko Hotta
International journal of urology : official journal of the Japanese Urological Association, 26, 12, 1137, 1137, Dec. 2019, [Peer-reviewed], [International Magazine]
English - 尿中エキソソーム性KIAMタンパク質は腎移植後の活性型の抗体を介した慢性拒絶反応に関する新規の非侵襲的診断バイオマーカーである(Urinary exosomal KIAM protein is a novel non-invasive diagnostic biomarker for chronic active antibody-mediated rejection after kidney transplantation)
高田 祐輔, 上村 大輔, 樋口 はるか, 岩見 大基, 堀田 記世彦, 篠原 信雄, 村上 正晃
西日本泌尿器科, 81, 増刊, 134, 134, (一社)西日本泌尿器科学会, Oct. 2019
English - 二重濾過血漿分離交換法
太田 稔, 岩見 大基, 堀田 記世彦, 松本 剛直, 千葉 裕基, 岡本 花織, 篠原 信雄
日本アフェレシス学会雑誌, 38, Suppl., 133, 133, (一社)日本アフェレシス学会, Oct. 2019
Japanese - 血液型不適合腎移植〜長期成績向上に向けて〜 血液型不適合腎移植における抗体関連型拒絶反応の長期成績に与える影響
岩見 大基, 堀田 記世彦, 篠原 信雄
移植, 54, 総会臨時, 181, 181, (一社)日本移植学会, Sep. 2019
Japanese - 血液混合キメリズムにより誘導された腎移植免疫寛容患者の免疫モニタリング
堀田 記世彦, 大浦 哲, 岩原 直也, 岩見 大基, 篠原 信雄, Sachs David H., Cosimi A. Benedict, 河合 達郎
移植, 54, 総会臨時, 198, 198, (一社)日本移植学会, Sep. 2019
Japanese - 血液型不適合腎移植後の抗体関連型拒絶反応の臨床像の検討
岩見 大基, 堀田 記世彦, 篠原 信雄
MHC: Major Histocompatibility Complex, 26, 2Suppl., 110, 110, (一社)日本組織適合性学会, Sep. 2019
Japanese - 後腹膜鏡下ドナー腎採取術の提供側による成績比較
岩見 大基, 堀田 記世彦, 岩原 直也, 篠原 信雄
泌尿器外科, 32, 7, 991, 991, 医学図書出版(株), Jul. 2019
Japanese - Percentage of CD19+ Cells in Peripheral Blood Lymphocytes After Rituximab-Based Desensitization as a Predictor of Acute Antibody-Mediated Rejection in ABO-Incompatible Kidney Transplantation.
T Hirose, D Iwami, K Hotta, H Sasaki, H Higuchi, N Shinohara
Transplantation proceedings, 51, 5, 1382, 1386, Jun. 2019, [Peer-reviewed], [International Magazine]
English, BACKGROUND: Rituximab (RIT) is effective as a part of the desensitization therapy before ABO-incompatible kidney transplantation (ABOi-KTx), and a single dose of RIT at 375 mg/m2 or less is recommended. However, adequate RIT dose recommendations have not yet been established for individual recipients. Therefore, we evaluated the relationship between the proportion of B cells in peripheral blood and acute antibody-mediated rejection (AAMR). METHODS: Forty-four consecutive ABOi-KTx recipients were enrolled in this retrospective study. Before transplantation, subjects were treated with RIT at various doses, ranging from 65 to 400 mg/body (46-263 mg/m2), followed by plasmapheresis and intravenous immunoglobulin as a desensitization therapy. The percentage of CD19+ cells in the total peripheral blood lymphocytes population (%CD19) was determined the day before transplantation. Transplant recipients were divided into 2 groups according to pretransplant %CD19, as follows: low %CD19 group, ≤ 1.2% (n = 35) and high %CD19 group, > 1.2% (n = 9). The relationship between %CD19 and incidence of AAMR was evaluated, and the predicting factors for AAMR incidence were determined by univariate and multivariate analyses. RESULTS: The incidence of AAMR was significantly higher in the high %CD19 group than in the low %CD19 group (44.4% vs 5.7%, P = .006). Furthermore, multivariate analysis showed that %CD19 > 1.2% was the only independent factor to predict AAMR, with an odds ratio of 14.31 (P = .038). CONCLUSION: High %CD19 values after rituximab administration in ABOi-KTx recipients implies insufficient depletion of B cells, which can lead to AAMR. - A 2-mm Cutoff Value Is Reasonable and Feasible for Vascular Reconstruction in a Kidney Allograft With Multiple Arteries.
Daiki Iwami, Kiyohiko Hotta, Hajime Sasaki, Takayuki Hirose, Haruka Higuchi, Yusuke Takada, Naoya Iwahara, Nobuo Shinohara
Transplantation proceedings, 51, 5, 1317, 1320, Jun. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: Multiple renal arteries are found in approximately 20% of living donor kidneys. We have been using an accessory artery cutoff diameter of 2 mm on preoperative computed tomography angiography to determine whether to sacrifice or reconstruct the artery. In this study, we assessed the validity and feasibility of this cutoff value. METHODS: Living related kidney recipients from 2005 to 2013 were enrolled in this retrospective study. The diameter of the accessory artery and adverse events were evaluated. The lost parenchymal volume (%) due to vascular obstruction or branch ligation was calculated by computed tomography volumetry. RESULTS: Among 128 kidney transplants, 30 donor kidneys had multiple arteries. Accessory arteries were reconstructed in 18 cases and intentionally ligated in 12 cases (mean diameter of accessory arteries, 3.10 [SD, 0.75] mm and 1.81 [SD, 0.28] mm, respectively). The mean estimated glomerular filtration rate at 1 or 12 months after transplant was not significantly different between the groups. Among reconstructed cases, 14 cases (77.8%) had good patency in the reconstructed arteries whereas the other 4 had vascular complications. The percentage of lost parenchymal volume due to ligation or occlusion of the reconstructed artery (calculated in 16 cases) was predictable with the following formula: lost volume (%) = 9.09 × diameter (mm) - 10.5 (P= .03, rs= 0.533 by Spearman rank correlation coefficient). This formula indicated that ligation of a 2-mm accessory artery leads to 7.68% loss of the renal parenchyma. CONCLUSIONS: Reconstruction using a cutoff diameter of 2 mm is worth attempting in terms of the success rate and graft function. Sacrifice of a 2-mm accessory artery leads to parenchymal loss of <8%. - Response to Letter to the Editor RE: Hirose et al., Safety and Efficacy of Retroperitoneoscopic Living Donor Nephrectomy: Comparison of Early Complication, Donor and Recipient Outcome with Hand-Assisted Laparoscopic Living Donor Nephrectomy by Hirose et al. (From: Goyal K, Singh AK, Kumar U, et al. J Endourol 2019;33:503; DOI: 10.1089/end.2019.0099).
Kiyohiko Hotta, Takayuki Hirose, Daiki Iwami, Nobuo Shinohara
Journal of endourology, 33, 6, 504, 504, Jun. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal - 多発性嚢胞腎に対する腎移植後の固有腎体積推移の検討
村西 雄貴, 岩見 大基, 堀田 記世彦, 樋口 はるか, 篠原 信雄
泌尿器外科, 32, 5, 515, 515, 医学図書出版(株), May 2019
Japanese - 血液浄化療法により長期生存を成している劣性栄養障害型表皮水疱症の一例
武田 紗夜, 西尾 妙織, 白鳥 里佳, 吉川 純平, 山本 準也, 松岡 奈央子, 石川 康暢, 中沢 大悟, 堀田 記世彦, 岩見 大基, 篠原 信雄
日本透析医学会雑誌, 52, Suppl.1, 649, 649, (一社)日本透析医学会, May 2019
Japanese - 腎移植時における多発性嚢胞腎に対する後腹膜鏡下腎摘出術
堀田 記世彦, 岩見 大基, 古御堂 純, 森田 研, 佐々木 元, 広瀬 貴行, 樋口 はるか, 高田 祐輔, 篠原 信雄
泌尿器外科, 32, 5, 507, 507, 医学図書出版(株), May 2019
Japanese - 腎移植時における多発性嚢胞腎に対する鏡視下後腹膜アプローチ腎摘術
堀田 記世彦, 岩見 大基, 森田 研, 古御堂 純, 田邉 起, 樋口 はるか, 岩原 直也, 金川 匡一, 望月 端吾, 篠原 信雄
日本泌尿器科学会総会, 107回, OP, 012, (一社)日本泌尿器科学会総会事務局, Apr. 2019
Japanese - 脳死膵腎移植の臓器摘出チームにおける臨床工学技士の取り組み
太田 稔, 岡本 花織, 千葉 裕基, 後藤 了一, 財津 雅昭, 川村 典生, 渡辺 正明, 山本 真由美, 柏浦 愛美, 鈴木 友己, 堀田 記世彦, 岩見 大基, 嶋村 剛
日本臨床工学技士会会誌, 66, 253, 253, (公社)日本臨床工学技士会, Apr. 2019
Japanese - 移植腎尿管に嵌頓した尿管結石を軟性尿管鏡にて抽石した一例
今 雅史, 堀田 記世彦, 岩見 大基, 樋口 はるか, 宮田 遥, 村西 雄貴, 篠原 信雄
日本尿路結石症学会誌, 17, 2, 175, 176, 日本尿路結石症学会, Mar. 2019
Japanese - mTOR阻害薬の適正活用法1 CNI腎毒性に対してCNI減量、離脱を目的としたエベロリムスの導入
堀田 記世彦, 岩見 大基, 岩原 直也, 高田 祐輔, 篠原 信雄
日本臨床腎移植学会プログラム・抄録集, 52回, 92, 92, (一社)日本臨床腎移植学会, Feb. 2019
Japanese - 腎臓内科医が腎移植に興味を持つ方策 当院の移植医・腎内科連携
岩見 大基, 堀田 記世彦, 岩原 直也, 篠原 信雄, 西尾 妙織
日本臨床腎移植学会プログラム・抄録集, 52回, 183, 183, (一社)日本臨床腎移植学会, Feb. 2019
Japanese - 当院における既存DSA陽性腎移植の検討
岩原 直也, 岩見 大基, 堀田 記世彦, 篠原 信雄
日本臨床腎移植学会プログラム・抄録集, 52回, 220, 220, (一社)日本臨床腎移植学会, Feb. 2019
Japanese - Editorial Comment from Dr Hotta to Clinical impact of glomerular basement membrane thickness on post-donation renal function in living donors.
Kiyohiko Hotta
International journal of urology : official journal of the Japanese Urological Association, 26, 2, 311, 311, Feb. 2019, [Peer-reviewed], [International Magazine]
English - Trends of kidney transplantation in Japan in 2018: Data from the kidney transplant registry
Takashi Yagisawa, Makiko Mieno, Naotsugu Ichimaru, Ken Morita, Michio Nakamura, Kiyohiko Hotta, Takashi Kenmochi, Kenji Yuzawa
Renal Replacement Therapy, 5, 1, BioMed Central Ltd., 29 Jan. 2019
English, Scientific journal - Addition of Anti-CD40 Monoclonal Antibody to Nonmyeloablative Conditioning With Belatacept Abrogated Allograft Tolerance Despite Induction of Mixed Chimerism.
Tetsu Oura, Kiyohiko Hotta, Ivy Rosales, Abbas Dehnadi, Kent Kawai, Hang Lee, A Benedict Cosimi, Tatsuo Kawai
Transplantation, 103, 1, 168, 176, Jan. 2019, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: We recently reported anti-CD40 monoclonal antibody and rapamycin (aCD40/rapa) to be a reliable, nontoxic, immunosuppressive regimen for combined islet and kidney transplantation (CIKTx) in nonhuman primates. In the current study, we attempted to induce allograft tolerance through the mixed chimerism approach using a conditioning regimen with aCD40 and belatacept (Bela). METHODS: Five CIKTx or kidney transplant alone recipients were treated with aCD40/rapa for 4 months. All recipients then received a conditioning regimen including horse antithymocyte globulin and aCD40/Bela. The results were compared with previous reports of recipients treated with Bela-based regimens. RESULTS: All 3 CIKTx recipients developed mixed chimerism, which was significantly superior to that observed in the previous Bela-based studies. Nevertheless, all CIKTx recipients in this study lost their islet and renal allografts as a result of cellular and humoral rejection on days 140, 89, and 84. The 2 kidney transplant-alone recipients were treated with the same conditioning regimen and suffered rejection on days 127 and 116, despite the development of excellent chimerism. B lymphocyte reconstitution dominated by memory phenotypes was associated with early development of donor-specific antibodies in 4 of 5 recipients. In vitro assays showed no donor-specific regulatory T cell expansion, which has been consistently observed in tolerant recipients with our mixed chimerism approach. CONCLUSIONS: Despite displaying excellent immunosuppressive efficacy, costimulatory blockade with anti-CD40 monoclonal antibody (2C10R4) may inhibit the induction of renal or islet allograft tolerance via a mixed chimerism approach. - Optimal Settings for Double Filtration Plasmapheresis With Targeted Removal Rate of Preexisting Antibody in Antibody-Incompatible Kidney Transplant.
Iwami D, Miura M, Chiba Y, Ota M, Matsumoto T, Hotta K, Sasaki H, Hirose T, Harada H, Shinohara N
Transplantation proceedings, 50, 10, 3478, 3482, Dec. 2018, [Peer-reviewed] - Safety and Efficacy of Retroperitoneoscopic Living Donor Nephrectomy: Comparison of Early Complication, Donor and Recipient Outcome with Hand-Assisted Laparoscopic Living Donor Nephrectomy.
Takayuki Hirose, Kiyohiko Hotta, Daiki Iwami, Hiroshi Harada, Ken Morita, Tatsu Tanabe, Hajime Sasaki, Nobuyuki Fukuzawa, Toshimori Seki, Nobuo Shinohara
Journal of endourology, 32, 12, 1120, 1124, Dec. 2018, [Peer-reviewed], [International Magazine]
English, Scientific journal, INTRODUCTION: Laparoscopic surgery has been a standard procedure of living donor nephrectomy (LDN). Transperitoneal hand-assisted laparoscopic LDN (HALDN) has been commonly reported by many centers with excellent outcome. However, there are few studies reporting retroperitoneoscopic LDN (RPLDN). MATERIALS AND METHODS: Four hundred four consecutive kidney donors (124 men, 280 women) were enrolled in this study. Age of the donors was 55.0 ± 10.7 years. RPLDN was performed for 294 donors, and HALDN for 110 donors. We compared perioperative donor outcome and early complication rates between RPLDN and HALDN to evaluate the safety and efficacy of RPLDN. RESULTS: Intraoperative blood loss was significantly less in RPLDN than in HALDN (p < 0.05). The conversion rate to open surgery was similar between the two groups. The intraoperative complication rate was 1.0% (two vascular injuries and one bowel injury) in RPLDN and 0.9% (one vascular injury) in HALDN. The postoperative complication rate was 3.4% (six surgical site infections, two postoperative bleeding, one colon perforation, one ileus, one rhabdomyolysis) in RPLDN and 1.8% (two surgical site infections) in HALDN. Although warm ischemic time was significantly longer in RPLDN than in HALDN (p < 0.01), the incidence of delayed graft function was similar between the two groups. Furthermore, there was no difference in 1-year graft survival between the two groups. CONCLUSIONS: Both RPLDN and HALDN procedures were well tolerated with minimal complication rates, and both procedures showed similar impact on recipient graft function. These results suggest that RPLDN could be a feasible option for LDN as well as HALDN. - ブタ臓器を用いた簡便な腹腔鏡トレーニングモデルの開発
樋口 まどか, 安部 崇重, 堀田 記世彦, 森田 研, 宮田 遥, 菊池 央, 松本 隆児, 大澤 崇宏, 倉島 庸, 篠原 信雄
日本泌尿器内視鏡学会総会, 32回, O, 6, (一社)日本泌尿器内視鏡・ロボティクス学会, Nov. 2018
Japanese - バーチャルリアリティーシミュレーター腹腔鏡下腎摘除術の妥当性の検証
宮田 遥, 安部 崇重, 樋口 まどか, 堀田 記世彦, 大澤 崇宏, 松本 隆児, 菊地 央, 倉島 庸, 村井 祥代, 篠原 信雄
日本泌尿器内視鏡学会総会, 32回, DP, 5, (一社)日本泌尿器内視鏡・ロボティクス学会, Nov. 2018
Japanese - ブタ臓器を用いた簡便な腹腔鏡トレーニングモデルの開発
樋口 まどか, 安部 崇重, 堀田 記世彦, 森田 研, 宮田 遥, 菊池 央, 松本 隆児, 大澤 崇宏, 倉島 庸, 篠原 信雄
日本泌尿器内視鏡学会総会, 32回, O, 6, (一社)日本泌尿器内視鏡・ロボティクス学会, Nov. 2018
Japanese - バーチャルリアリティーシミュレーター腹腔鏡下腎摘除術の妥当性の検証
宮田 遥, 安部 崇重, 樋口 まどか, 堀田 記世彦, 大澤 崇宏, 松本 隆児, 菊地 央, 倉島 庸, 村井 祥代, 篠原 信雄
日本泌尿器内視鏡学会総会, 32回, DP, 5, (一社)日本泌尿器内視鏡・ロボティクス学会, Nov. 2018
Japanese - 膜型分離器の可能性 二重膜濾過血漿交換法における新たな血漿分離器選択の可能性
太田 稔, 岩見 大基, 堀田 記世彦, 松本 剛直, 千葉 裕基, 岡本 花織, 篠原 信雄
日本アフェレシス学会雑誌, 37, Suppl., 79, 79, (一社)日本アフェレシス学会, Oct. 2018
Japanese - 腎移植の慢性抗体関連型拒絶反応における早期診断バイオマーカー、治療ターゲットOrosomucoid1(ORM1)の可能性
樋口 はるか, 堀田 記世彦, 岩見 大基, 村上 正晃, 篠原 信雄
移植, 53, 総会臨時, 483, 483, (一社)日本移植学会, Sep. 2018
Japanese - 常染色体優性多発性嚢胞腎に対する腎移植の自己腎容量に応じた手術手技の選択
堀田 記世彦, 岩見 大基, 田邉 起, 岩原 直也, 古御堂 純, 森田 研, 金川 匡一, 篠原 信雄
移植, 53, 総会臨時, 507, 507, (一社)日本移植学会, Sep. 2018
Japanese - 移植腎尿管に嵌頓した尿管結石を軟性尿管鏡にて抽石した一例
今 雅史, 堀田 記世彦, 岩見 大基, 樋口 はるか, 宮田 遥, 村西 雄貴, 篠原 信雄
日本尿路結石症学会誌, 17, 1, 56, 56, 日本尿路結石症学会, Aug. 2018
Japanese - IgA腎症患者に対する腎移植の検討
樋口 はるか, 堀田 記世彦, 岩見 大基, 高田 祐輔, 篠原 信雄
泌尿器外科, 31, 臨増, 821, 821, 医学図書出版(株), Jun. 2018
Japanese - Successful treatment of hidradenitis suppurativa with rituximab for a patient with idiopathic carpotarsal osteolysis and chronic active antibody-mediated rejection.
Kanae Takahashi, Teruki Yanagi, Shinya Kitamura, Hiroo Hata, Keisuke Imafuku, Daiki Iwami, Kiyohiko Hotta, Ken Morita, Nobuo Shinohara, Hiroshi Shimizu
The Journal of dermatology, 45, 5, e116-e117, e117, Blackwell Publishing Ltd, May 2018, [Peer-reviewed], [International Magazine]
English - Spontaneous reduction of native kidney size involving angiomyolipoma lesions in a kidney transplant recipient with tuberous sclerosis complex.
Hajime Sasaki, Daiki Iwami, Kiyohiko Hotta, Ken Morita, Tomoaki Naka, Nobuo Shinohara
International journal of urology : official journal of the Japanese Urological Association, 25, 5, 513, 514, Blackwell Publishing, May 2018, [Peer-reviewed], [International Magazine]
English, Scientific journal - Long-term Nonhuman Primate Renal Allograft Survival Without Ongoing Immunosuppression in Recipients of Delayed Donor Bone Marrow Transplantation.
Kiyohiko Hotta, Tetsu Oura, Abbas Dehnadi, Svjetlan Boskovic, Masatoshi Matsunami, Ivy Rosales, Rex N Smith, Robert B Colvin, A Benedict Cosimi, Tatsuo Kawai
Transplantation, 102, 4, e128-e136, e136, Apr. 2018, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: We have previously reported successful induction of renal allograft tolerance in nonhuman primates (NHP) after an initial posttransplant period of conventional immunosuppression (delayed tolerance) using a nonmyeloablative conditioning regimen consisting of anti-CD154 and anti-CD8 mAbs plus equine antithymocyte globulin (Atgam) and donor bone marrow transplantation (DBMT). Because these reagents are not currently clinically available, the protocol was revised to be applicable to human recipients of deceased donor allografts. METHOD: Four cynomolgus monkeys received major histocompatibility complex-mismatched kidney allografts with conventional immunosuppression for 4 months. The recipients were then treated with a nonmyeloablative conditioning regimen consisting of thymoglobulin, belatacept, and DBMT. The results were compared with recipients treated with conditioning regimen consisting of Atgam and anti-CD154 mAb, with and without anti-CD8 mAb. RESULTS: In 4 consecutive NHP recipients treated with the modified conditioning regimen, homeostatic recovery of CD8 TEM was delayed until after day 20 and multilineage chimerism was successfully induced. Three of the 4 recipients achieved long-term allograft survival (>728, >540, >449 days) without ongoing maintenance immunosuppression. Posttransplant MLR showed loss of antidonor CD8 T cell and CD4 IFNγ responses with expansion of CD4FOXP3 regulatory T cells. However, the late development of donor-specific antibody in NHP recipients confirms the need for additional anti-B-cell depletion with agents, such as rituximab, as has been shown in our clinical trials. CONCLUSIONS: This study provides proof of principle that induction of mixed chimerism and long-term renal allograft survival without immunosuppression after delayed DBMT is possible with clinically available reagents. - Gastrointestinal: Transurethral endoscopic retrograde pancreatography
K. Kawakubo, M. Kuwatani, T. Shimamura, K. Yamashita, R. Goto, M. Watanabe, Y. Koshizuka, N. Kawamura, D. Iwami, K. Hotta, I. Sano, R. Sugiura, S. Kato, N. Shinohara, A. Taketomi, N. Sakamoto
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 32, 11, 1791, 1791, Nov. 2017, [Peer-reviewed]
English - Cytomegalovirus peritonitis after kidney transplantation diagnosed through histopathological examination.
Kiyohiko Hotta, Yuichiro Fukasawa, Yoshiki Wada, Nobuyuki Fukuzawa, Toshimori Seki, Hiroshi Harada
Transplant infectious disease : an official journal of the Transplantation Society, 19, 4, Aug. 2017, [Peer-reviewed], [International Magazine]
English, Scientific journal - 糖尿病性腎症を合併した献腎ドナーからの腎移植における長期成績の検討
堀田 記世彦, 岩見 大基, 広瀬 貴行, 佐々木 元, 樋口 はるか, 高田 祐輔, 福澤 信之, 原田 浩, 篠原 信雄
日本泌尿器科学会総会, 105回, OP78, 6, (一社)日本泌尿器科学会総会事務局, Apr. 2017
Japanese - Atrophic bladder in long-term dialysis patients increases the risk for urological complications after kidney transplantation.
Kiyohiko Hotta, Masayoshi Miura, Yoshiki Wada, Nobuyuki Fukuzawa, Daiki Iwami, Hajime Sasaki, Toshimori Seki, Hiroshi Harada
International journal of urology : official journal of the Japanese Urological Association, 24, 4, 314, 319, Apr. 2017, [Peer-reviewed], [International Magazine]
English, Scientific journal - Immunosuppression With CD40 Costimulatory Blockade Plus Rapamycin for Simultaneous Islet-Kidney Transplantation in Nonhuman Primates
T. Oura, K. Hotta, J. Lei, J. Markmann, I. Rosales, A. Dehnadi, K. Kawai, D. Ndishabandi, R. -N. Smith, A. B. Cosimi, T. Kawai
AMERICAN JOURNAL OF TRANSPLANTATION, 17, 3, 646, 656, Mar. 2017, [Peer-reviewed]
English, Scientific journal - 【腎移植後の尿路合併症とその対策】尿路異常を伴う小児腎移植の治療戦略
岩見 大基, 守屋 仁彦, 堀田 記世彦, 森田 研, 篠原 信雄
腎移植・血管外科, 29, 3, 166, 172, 腎移植・血管外科研究会, 2017
Japanese - 【腎移植後の尿路合併症とその対策】腎移植後の下部尿路障害発生のリスク因子とその対応
原田 浩, 堀田 記世彦, 広瀬 貴行, 三浦 正義
腎移植・血管外科, 29, 3, 160, 165, 腎移植・血管外科研究会, 2017
Japanese - Highly Immunogenic DQBI Mismatch Eplets Are Associated With Development of Chronic Active Antibody-Mediated Rejection: A First Report From Japan
D. Iwami, K. Hotta, H. Sasaki, T. Hirose, H. Higuchi, Y. Takada, N. Shinohara
TRANSPLANTATION PROCEEDINGS, 49, 1, 84, 87, Jan. 2017, [Peer-reviewed]
English, Scientific journal - ABO血液型不適合腎移植におけるrituximabの適正使用量とモニタリングの有用性
広瀬 貴行, 岩見 大基, 堀田 記世彦, 佐々木 元, 樋口 はるか, 高田 祐輔, 篠原 信雄
MHC: Major Histocompatibility Complex, 23, 2Suppl., 88, 88, (一社)日本組織適合性学会, Oct. 2016
Japanese - ドナータイプ赤血球処理にて陰性化したTリンパ球クロスマッチ偽陽性の2例
岩見 大基, 伊藤 誠, 堀田 記世彦, 佐々木 元, 広瀬 貴行, 樋口 はるか, 高田 祐輔, 篠原 信雄
MHC: Major Histocompatibility Complex, 23, 2Suppl., 90, 90, (一社)日本組織適合性学会, Oct. 2016
Japanese - 血液型不適合腎移植におけるrituximabの適正量決定のためのCD19陽性細胞
広瀬 貴行, 岩見 大基, 堀田 記世彦, 佐々木 元, 樋口 はるか, 高田 祐輔, 篠原 信雄
移植, 51, 総会臨時, 229, 229, (一社)日本移植学会, Sep. 2016
Japanese - 当科におけるDe novo DSA症例の治療成績
佐々木 元, 岩見 大基, 広瀬 貴行, 高田 祐輔, 堀田 記世彦, 篠原 信雄
移植, 51, 総会臨時, 327, 327, (一社)日本移植学会, Sep. 2016
Japanese - 先天性ネフローゼ症候群の小児腎移植4例
広瀬 貴行, 岩見 大基, 森田 研, 堀田 記世彦, 佐々木 元, 樋口 はるか, 高田 祐輔, 篠原 信雄
移植, 51, 総会臨時, 378, 378, (一社)日本移植学会, Sep. 2016
Japanese - 移植腎における炎症アンプの活性化
樋口 はるか, 岩見 大基, 堀田 記世彦, 佐々木 元, 広瀬 貴行, 篠原 信雄, 村上 正晃
移植, 51, 総会臨時, 381, 381, (一社)日本移植学会, Sep. 2016
Japanese - Induced regulatory T cells in allograft tolerance via transient mixed chimerism.
Kiyohiko Hotta, Akihiro Aoyama, Tetsu Oura, Yohei Yamada, Makoto Tonsho, Kyu Ha Huh, Kento Kawai, David Schoenfeld, James S Allan, Joren C Madsen, Gilles Benichou, Rex-Neal Smith, Robert B Colvin, David H Sachs, A Benedict Cosimi, Tatsuo Kawai
JCI insight, 1, 10, 07 Jul. 2016, [Peer-reviewed], [International Magazine]
English, Scientific journal, Successful induction of allograft tolerance has been achieved in nonhuman primates (NHPs) and humans via induction of transient hematopoietic chimerism. Since allograft tolerance was achieved in these recipients without durable chimerism, peripheral mechanisms are postulated to play a major role. Here, we report our studies of T cell immunity in NHP recipients that achieved long-term tolerance versus those that rejected the allograft (AR). All kidney, heart, and lung transplant recipients underwent simultaneous or delayed donor bone marrow transplantation (DBMT) following conditioning with a nonmyeloablative regimen. After DBMT, mixed lymphocyte culture with CFSE consistently revealed donor-specific loss of CD8+ T cell responses in tolerant (TOL) recipients, while marked CD4+ T cell proliferation in response to donor antigens was found to persist. Interestingly, a significant proportion of the proliferated CD4+ cells were FOXP3+ in TOL recipients, but not in AR or naive NHPs. In TOL recipients, CD4+FOXP3+ cell proliferation against donor antigens was greater than that observed against third-party antigens. Finally, the expanded Tregs appeared to be induced Tregs (iTregs) that were converted from non-Tregs. These data provide support for the hypothesis that specific induction of iTregs by donor antigens is key to long-term allograft tolerance induced by transient mixed chimerism. - 抗赤血球抗体による溶血性貧血を来したABO不適合腎移植の1例
広瀬 貴行, 堀田 記世彦, 岩見 大基, 田邉 起, 佐々木 元, 大石 悠一郎, 樋口 はるか, 篠原 信雄, 森田 研
腎移植・血管外科, 26, 1, 97, 101, 腎移植・血管外科研究会, Mar. 2016
Japanese - Kidney Versus Islet Allograft Survival After Induction of Mixed Chimerism With Combined Donor Bone Marrow Transplantation.
Tetsu Oura, Dicken S C Ko, Svjetlan Boskovic, John J O'Neil, Vaja Chipashvili, Maria Koulmanda, Kiyohiko Hotta, Kento Kawai, Ognjenka Nadazdin, R Neal Smith, A B Cosimi, Tatsuo Kawai
Cell transplantation, 25, 7, 1331, 41, 2016, [Peer-reviewed], [International Magazine]
English, Scientific journal - Clinical significance and therapeutic potential of prostate cancer antigen-1/ALKBH3 in human renal cell carcinoma.
Kiyohiko Hotta, Masayuki Sho, Kiyohide Fujimoto, Keiji Shimada, Ichiro Yamato, Satoshi Anai, Hiroshi Harada, Kazutake Tsujikawa, Noboru Konishi, Nobuo Shinohara, Yoshiyuki Nakajima
Oncology reports, 34, 2, 648, 54, Aug. 2015, [Peer-reviewed], [International Magazine]
English, Scientific journal - Transient mixed chimerism for allograft tolerance.
Tetsu Oura, Kiyohiko Hotta, A B Cosimi, Tatsuo Kawai
Chimerism, 6, 1-2, 21, 6, 03 Apr. 2015, [Peer-reviewed], [International Magazine]
English, Scientific journal, Mixed chimerism discovered in Freemartin cattle by Ray Owen 70 years ago paved the way for research on immune tolerance. Since his discovery, significant progress has been made in the effort to induce allograft tolerance via mixed chimerism in various murine models. However, induction of persistent mixed chimerism has proved to be extremely difficult in major histocompatibility complex mismatched humans. Chimerism induced in humans tends to either disappear or convert to full donor chimerism, depending on the intensity of the conditioning regimen. Nevertheless, our studies in both NHPs and humans have clearly demonstrated that renal allograft tolerance can be induced by transient mixed chimerism. Our studies have shown that solid organ allograft tolerance via transient mixed chimerism 1) requires induction of multilineage hematologic chimerism, 2) depends on peripheral regulatory mechanisms, rather than thymic deletion, for long-term maintenance, 3) is organ specific (kidney and lung but not heart allograft tolerance are feasible). A major advantage of tolerance induction via transient mixed chimerism is exclusion of the risk of graft-versus-host disease. Our ongoing studies are directed toward improving the consistency of tolerance induction, reducing the morbidity of the conditioning regimen, substituting clinically available agents, such as Belatacept for the now unavailable anti-CD2 monoclonal antibody, and extending the protocol to recipients of deceased donor allografts. - 腎移植300例の長期成績
森田 研, 広瀬 貴行, 佐々木 元, 田邉 起, 堀田 記世彦, 野々村 克也
泌尿器外科, 27, 12, 1967, 1967, 医学図書出版(株), Dec. 2014
Japanese - 外傷性尿管断裂の一例
岩原 直也, 堀田 記世彦, 守屋 仁彦, 宮島 直人, 田邊 起, 広瀬 貴行, 村橋 範浩, 宮田 遥, 篠原 信雄, 野々村 克也
泌尿器外科, 27, 12, 1967, 1968, 医学図書出版(株), Dec. 2014
Japanese - 当院での移植腎結石・石灰化症例の検討
田邉 起, 森田 研, 堀田 記世彦, 佐々木 元, 広瀬 貴行, 三浦 正義, 野々村 克也
泌尿器外科, 27, 12, 1976, 1976, 医学図書出版(株), Dec. 2014
Japanese - 移植時のグラフト腎結石症例の検討
田邉 起, 堀田 記世彦, 広瀬 貴行, 佐々木 元, 森田 研, 野々村 克也
泌尿器外科, 27, 臨増, 752, 752, 医学図書出版(株), May 2014
Japanese - 腎移植にみるウイルス感染症 予防・診断・治療 サイトメガロウイルス感染症の腎移植における問題点
森田 研, 岩見 大基, 堀田 記世彦, 田邉 起, 佐々木 元, 広瀬 貴行
日本泌尿器科学会総会, 102回, 316, 316, (一社)日本泌尿器科学会総会事務局, Apr. 2014
Japanese - Significant involvement of herpesvirus entry mediator in human esophageal squamous cell carcinoma.
Kazuhiro Migita, Masayuki Sho, Keiji Shimada, Satoshi Yasuda, Ichiro Yamato, Tomoyoshi Takayama, Sohei Matsumoto, Kohei Wakatsuki, Kiyohiko Hotta, Tetsuya Tanaka, Masahiro Ito, Noboru Konishi, Yoshiyuki Nakajima
Cancer, 120, 6, 808, 17, 15 Mar. 2014, [Peer-reviewed], [International Magazine]
English, Scientific journal - 腎移植後に尿路再建手術を施行した小児慢性腎不全の2例
広瀬 貴行, 青柳 俊紀, 田邊 起, 堀田 記世彦, 橘田 岳也, 福澤 信之, 三井 貴彦, 守屋 仁彦, 森田 研, 野々村 克也
泌尿器外科, 27, 2, 249, 249, 医学図書出版(株), Feb. 2014
Japanese - ABO血液型不適合腎移植における低用量Rituximab使用の成績
広瀬 貴行, 田邉 起, 堀田 記世彦, 森田 研, 野々村 克也
泌尿器外科, 27, 2, 254, 254, 医学図書出版(株), Feb. 2014
Japanese - 後腹膜鏡下ドナー腎採取術における摘出方法の検討
福澤 信之, 森田 研, 岩見 大基, 堀田 記世彦, 田邊 起, 佐々木 元, 広瀬 貴行, 原田 浩, 関 利盛, 富樫 正樹, 野々村 克也
泌尿器外科, 27, 2, 254, 254, 医学図書出版(株), Feb. 2014
Japanese - 鏡視下ドナー腎採取術の臨床的検討
堀田 記世彦, 森田 研, 田邉 起, 広瀬 貴行, 佐々木 元, 野々村 克也
泌尿器外科, 27, 2, 262, 262, 医学図書出版(株), Feb. 2014
Japanese - 生体腎移植ドナーの腎摘出後のCCrとeGFRの相関に影響する因子の検討
高橋 一成, 森田 研, 広瀬 貴行, 田邉 起, 堀田 記世彦, 野々村 克也
泌尿器外科, 27, 2, 264, 264, 医学図書出版(株), Feb. 2014
Japanese - Tonsillectomy ameliorates histological damage of recurrent immunoglobulin A nephropathy after kidney transplantation.
Kiyohiko Hotta, Yuichiro Fukasawa, Mayuko Akimoto, Tatsu Tanabe, Hajime Sasaki, Nobuyuki Fukuzawa, Toshimori Seki, Masaki Togashi, Hiroshi Harada
Nephrology (Carlton, Vic.), 18, 12, 808, 12, Dec. 2013, [Peer-reviewed], [International Magazine]
English, Scientific journal - 腹腔鏡下膀胱全摘術 市立札幌病院で行ってきた腹腔鏡下膀胱全摘術の実際
関 利盛, 三浦 正義, 高田 徳容, 堀田 記世彦, 岩見 大基, 望月 端吾, 田中 博, 福澤 信之, 原田 浩
日本内視鏡外科学会雑誌, 18, 7, 364, 364, (一社)日本内視鏡外科学会, Nov. 2013
Japanese - 鏡視下ドナー腎採取術の臨床的検討
広瀬 貴行, 堀田 記世彦, 森田 研, 田邉 起, 佐々木 元, 野々村 克也
Japanese Journal of Endourology, 26, 3, 235, 235, (一社)日本泌尿器内視鏡学会, Nov. 2013
Japanese - Long-term clinicopathological impact of calcineurin inhibitor cessation without specific cytoreductive induction in kidney transplantation
Tatsu Tanabe, Ken Morita, Hiromi Fujita, Kanako Hatanaka, Yayoi Ogawa, Takayuki Hirose, Hajime Sasaki, Daiki Iwami, Kiyohiko Hotta, Katsuya Nonomura
CLINICAL TRANSPLANTATION, 27, 9, 13, Nov. 2013, [Peer-reviewed]
English, Scientific journal - 末期腎不全患者の腎移植後膀胱容量・機能の改善
広瀬 貴行, 堀田 記世彦, 森田 研, 三井 貴彦, 田邉 起, 佐々木 元, 野々村 克也
移植, 48, 総会臨時, 360, 360, (一社)日本移植学会, Aug. 2013
Japanese - 当院のエベロリムス使用経験
田邉 起, 堀田 記世彦, 森田 研, 広瀬 貴行, 佐々木 元, 野々村 克也
移植, 48, 総会臨時, 429, 429, (一社)日本移植学会, Aug. 2013
Japanese - 生体腎移植レシピエントの移植前のドナーに対する認知と移植後の気分状態との関連
関口 真有, 高垣 耕企, 安藤 孟梓, 金澤 潤一郎, 本谷 亮, 佐藤 真澄, 原田 浩, 堀田 記世彦, 平野 哲夫, 坂野 雄二
日本認知療法学会・日本行動療法学会プログラム&抄録・発表論文集, 13回・39回, B, 104, 日本認知療法学会・日本行動療法学会, Aug. 2013
Japanese - 小児PEKT(Preemptive Kidney Transplantation)の適応を見極める 小児腎不全に対する未透析腎移植(PEKT)の現状
森田 研, 福澤 信之, 堀田 記世彦, 岩見 大基, 田邉 起, 佐々木 元, 広瀬 貴行, 野々村 克也
日本小児腎不全学会雑誌, 33, 32, 35, 日本小児腎不全学会, Jul. 2013
Japanese - 小児腹膜透析カテーテル変位症例に対する腹腔鏡下カテーテル位置整復・固定術の検討
菅野 由岐子, 広瀬 貴行, 田邊 起, 堀田 記世彦, 森田 研, 野々村 克也
日本小児腎不全学会雑誌, 33, 91, 91, 日本小児腎不全学会, Jul. 2013
Japanese - 献腎移植における抗ドナー抗体検索の意義
堀田 記世彦, 森田 研, 原田 浩, 福澤 信之, 広瀬 貴行, 田邊 起, 岩見 大基, 佐々木 元, 野々村 克也
泌尿器外科, 26, 臨増, 714, 714, 医学図書出版(株), May 2013
Japanese - 献腎移植後に前腕内シャントを閉鎖後、顕在化した骨間動静脈瘻の一例
森田 研, 千葉 博基, 広瀬 貴行, 田邉 起, 堀田 記世彦, 池田 正起, 古川 洋志, 野々村 克也
日本透析医学会雑誌, 46, Suppl.1, 536, 536, (一社)日本透析医学会, May 2013
Japanese - Clinical impact of tumor-infiltrating CD45RO⁺ memory T cells on human gastric cancer.
Kohei Wakatsuki, Masayuki Sho, Ichiro Yamato, Tomoyoshi Takayama, Sohei Matsumoto, Tetsuya Tanaka, Kazuhiro Migita, Masahiro Ito, Kiyohiko Hotta, Yoshiyuki Nakajima
Oncology reports, 29, 5, 1756, 62, May 2013, [Peer-reviewed], [International Magazine]
English, Scientific journal - 小児未透析腎移植における生着率と移植後合併症
森田 研, 広瀬 貴行, 佐々木 元, 田邊 起, 堀田 記世彦, 篠原 信雄, 野々村 克也
日本泌尿器科学会雑誌, 104, 2, 243, 243, (一社)日本泌尿器科学会, Mar. 2013
Japanese - 鏡視下ドナー腎採取術の臨床的検討
堀田 記世彦, 森田 研, 田邉 起, 広瀬 貴行, 佐々木 元, 野々村 克也
日本泌尿器科学会雑誌, 104, 2, 290, 290, (一社)日本泌尿器科学会, Mar. 2013
Japanese - Class II抗ドナー抗体が陽性であった脳死下腎移植の1例
田邉 起, 森田 研, 樋口 まどか, 杉原 祐介, 広瀬 貴行, 堀田 記世彦, 福澤 信之, 伊藤 誠, 米岡 麻紀, 野々村 克也
今日の移植, 25, 6, 545, 546, (株)日本医学館, Nov. 2012
Japanese - PCA-1/ALKBH3 contributes to pancreatic cancer by supporting apoptotic resistance and angiogenesis.
Ichiro Yamato, Masayuki Sho, Keiji Shimada, Kiyohiko Hotta, Yuko Ueda, Satoshi Yasuda, Naoko Shigi, Noboru Konishi, Kazutake Tsujikawa, Yoshiyuki Nakajima
Cancer research, 72, 18, 4829, 39, 15 Sep. 2012, [Peer-reviewed], [International Magazine]
English, Scientific journal - 1型糖尿病患者に対する腎移植の成績
森田 研, 堀田 記世彦, 岩見 大基, 田邊 起, 佐々木 元, 広瀬 貴行, 福澤 信之, 野々村 克也, 原田 浩
移植, 47, 総会臨時, 195, 195, (一社)日本移植学会, Sep. 2012
Japanese - 献腎移植における抗ドナー抗体検索の意義
堀田 記世彦, 森田 研, 原田 浩, 田邊 起, 福澤 信之, 広瀬 貴行, 岩見 大基, 野々村 克也
移植, 47, 総会臨時, 207, 207, (一社)日本移植学会, Sep. 2012
Japanese - 後腹膜鏡下ドナー腎採取術における摘出方法の検討
福澤 信之, 森田 研, 岩見 大基, 堀田 記世彦, 佐々木 元, 田邊 起, 広瀬 貴行, 原田 浩, 野々村 克也
移植, 47, 総会臨時, 288, 288, (一社)日本移植学会, Sep. 2012
Japanese - 腎移植後に尿路再建手術を施行した小児慢性腎不全の2例
広瀬 貴行, 田邊 起, 堀田 記世彦, 福澤 信之, 守屋 仁彦, 森田 研, 野々村 克也
移植, 47, 総会臨時, 319, 319, (一社)日本移植学会, Sep. 2012
Japanese - Long-term histopathology of allografts in sensitized kidney recipients.
Masayoshi Miura, Hiroshi Harada, Yuichiro Fukasawa, Kiyohiko Hotta, Yosuke Itoh, Tohru Tamaki
Clinical transplantation, 26 Suppl 24, 32, 6, Jul. 2012, [Peer-reviewed], [International Magazine]
English, Scientific journal - Granulomatous tubulointerstitial nephritis in a renal allograft: three cases report and review of literature.
Kiyohiko Hotta, Yuichiro Fukasawa, Hajime Sasaki, Toshimori Seki, Masaki Togashi, Hiroshi Harada
Clinical transplantation, 26 Suppl 24, 70, 5, Jul. 2012, [Peer-reviewed], [International Magazine]
English, Scientific journal - Survey of practical management for induction of preemptive kidney transplantation by clinicians treating chronic kidney disease and transplant centers
HARADA Hiroshi, HOTTA Kiyohiko, TAKADA Norikata, SEKI Toshimori, TOGASHI Masaki
Journal of Japanese Society for Dialysis Therapy, 45, 6, 459, 466, The Japanese Society for Dialysis Therapy, 28 Jun. 2012
Japanese, Aim: Preemptive kidney transplantation (PKT) is an ideal renal replacement therapy for end-stage renal disease (ESRD); however, the rate of PKT is still low in Japan. This is because there is a disparity between the attitudes toward PKT, including the timing of referral to a transplant facility, between clinicians treating patients with chronic kidney disease (CKD) and transplant centers. Therefore, we conducted a survey of clinicians and transplant centers, inquiring about the timing of PKT induction. Materials and Methods: Forty-two attendees (all clinicians) of a seminar about renal disease who had treated CKD and the 31 leading Japanese kidney transplant facilities in 2009 were surveyed about PKT induction. The inquiries consisted of questions concerning the acknowledgment of the necessity for PKT, timing until referral, etc. Results: The response rate was 59% for attendees and 76% of them had referred patients to transplant facilities for PKT. Thirty-seven percent did so when the glomerular filtration rate (eGFR) fell to less than 30mL/min/1.73mm2. However, the same percent did not do so until it became less than 15mL/min/1.73mm2. More than half of the attendees referred patients for PKT when the serum creatinine was elevated to above 5mg/dL, and less than half of them did so when it rose to above 3mg/dL. On the other hand, more than half of the patients were referred to transplant facilities when their eGFR fell to under 15mL/min/1.73mm2; thus, only 20% could actually undergo PKT in most facilities. Surprisingly, 62% of the facilities experienced referral after dialysis access creation. Most facilities required earlier referral, in CKD stage3 or 4, which was a clear difference between CKD clinicians and transplant facilities. Conclusion: Even CKD clinicians who understand and favor PKT tend to delay referral to transplant facilities. Thus, suitable timing for referral is the key to increasing PKT. - Regional secondary focal segmental glomerulosclerosis in a transplanted kidney: resolution with treatment of a segmental renal artery stenosis.
Daiki Iwami, Hiroshi Harada, Hiroaki Usubuchi, Kiyohiko Hotta, Toshimori Seki, Masaki Togashi, Yuichiro Fukasawa
BMC nephrology, 13, 38, 38, 12 Jun. 2012, [Peer-reviewed], [International Magazine]
English, Scientific journal - Preservation of deep inferior epigastric artery at kidney transplantation prevents atrophy of lower rectus abdominis muscle.
Daiki Iwami, Hiroshi Harada, Ken Morita, Koji Oba, Nobuyuki Fukuzawa, Kiyohiko Hotta, Hajime Sasaki, Chihoko Miyazaki, Katsuya Nonomura
Transplantation, 93, 10, 1013, 6, 27 May 2012, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUNDS: The deep inferior epigastric artery (DIEA), which feeds the lower rectus abdominis muscle (lower RAM), is usually transected in kidney transplantation. In this study, we investigated whether preservation of DIEA can prevent lower RAM atrophy. METHODS: Two hundred and forty-five kidney transplant recipients (150 men and 95 women) were enrolled in the study (mean age 39.9 years) and were divided into two groups according to whether DIEA was transected (group A, n = 175) or preserved (group B, n = 70). The extent of lower RAM atrophy calculated in computed tomography (performed 1 year after transplantation) and incidence of lower RAM atrophy were compared between the two groups. The most predictive factors for lower RAM atrophy were assessed using a multivariate logistic regression model. RESULTS: The extent of lower RAM atrophy was significantly lower in group B (15.0 ± 18.5%) than that in group A (38.9 ± 25.4%, P = 0.003). The incidence of lower RAM atrophy was less prevalent in group B (20.0%) compared with that in group A (62.9%, P < 0.001). The sacrifice of DIEA was the only independent predictive factor for lower RAM atrophy (P < 0.001). CONCLUSIONS: Preservation of DIEA during kidney transplant can prevent lower RAM atrophy. - Percentages of Water, Muscle, and Bone Decrease and Lipid increases in Early Period After Successful Kidney Transplantation: A Body Composition Analysis
H. Harada, M. Nakamura, K. Hotta, D. Iwami, T. Seki, M. Togashi, T. Hirano, C. Miyazaki
TRANSPLANTATION PROCEEDINGS, 44, 3, 672, 675, Apr. 2012, [Peer-reviewed]
English, Scientific journal - Successful Kidney Transplantation Ameliorates Arterial Stiffness in End-Stage Renal Disease Patients
K. Hotta, H. Harada, H. Sasaki, D. Iwami, N. Fukuzawa, K. Morita, T. Seki, M. Togashi, K. Nonomura
TRANSPLANTATION PROCEEDINGS, 44, 3, 684, 686, Apr. 2012, [Peer-reviewed]
English, Scientific journal - Prognostic significance of CD45RO+memory T cells in renal cell carcinoma
K. Hotta, M. Sho, K. Fujimoto, K. Shimada, I. Yamato, S. Anai, N. Konishi, Y. Hirao, K. Nonomura, Y. Nakajima
BRITISH JOURNAL OF CANCER, 105, 8, 1191, 1196, Oct. 2011, [Peer-reviewed]
English, Scientific journal - 腎移植における移植床作成時の下腹壁動脈温存による腹直筋萎縮予防効果の検討
岩見 大基, 三浦 正義, 堀田 記世彦, 平野 哲夫, 原田 浩, 関 利盛, 富樫 正樹
泌尿器外科, 24, 臨増, 516, 516, 医学図書出版(株), Apr. 2011
Japanese - OP-055 転移性腎細胞癌に対するsorafenibの治療成績と有害事象の検討(腎腫瘍/薬物療法1,一般演題口演,第99回日本泌尿器科学会総会)
堀田 記世彦, 村橋 範浩, 佐藤 択矢, 高田 徳容, 望月 端吾, 平野 哲夫, 原田 浩, 関 利盛, 富樫 正樹
日本泌尿器科学会雑誌, 102, 2, 350, 350, 一般社団法人 日本泌尿器科学会, 2011
Japanese - PP-322 婦人科術後尿瘻に対する治療経験(一般演題ポスター発表・討論,一般演題ポスター,第99回日本泌尿器科学会総会)
関 利盛, 村橋 範浩, 佐藤 択矢, 高田 徳容, 望月 端吾, 富樫 正樹, 堀田 記世彦, 平野 哲夫, 原田 浩
日本泌尿器科学会雑誌, 102, 2, 457, 457, 一般社団法人 日本泌尿器科学会, 2011
Japanese - PP-990 他科疾患に対する尿管ステント挿入症例の検討(発表・討論,一般演題ポスター,第99回日本泌尿器科学会総会)
佐藤 択矢, 村橋 範浩, 望月 端吾, 高田 徳容, 堀田 記世彦, 原田 浩, 平野 哲夫, 関 利盛, 富樫 正樹
日本泌尿器科学会雑誌, 102, 2, 571, 571, 一般社団法人 日本泌尿器科学会, 2011
Japanese - PP-060 非尿路上皮癌を含む膀胱癌の臨床的検討(発表・討論,一般演題ポスター,第99回日本泌尿器科学会総会)
高田 徳容, 村橋 範浩, 佐藤 択矢, 堀田 記世彦, 望月 端吾, 原田 浩, 関 利盛, 平野 哲夫, 富樫 正樹
日本泌尿器科学会雑誌, 102, 2, 413, 413, 一般社団法人 日本泌尿器科学会, 2011
Japanese - PP-091 前立腺癌に対する前立腺全摘症例のPSA再発に関する検討(発表・討論,一般演題ポスター,第99回日本泌尿器科学会総会)
望月 端吾, 佐藤 択矢, 村橋 範浩, 高田 徳容, 関 利盛, 富樫 正樹, 堀田 記世彦, 原田 浩, 平野 哲夫
日本泌尿器科学会雑誌, 102, 2, 418, 418, 一般社団法人 日本泌尿器科学会, 2011
Japanese - PP-394 腎移植における複数動脈形成症例の検討(一般演題ポスター発表・討論,一般演題ポスター,第99回日本泌尿器科学会総会)
原田 浩, 堀田 記世彦, 関 利盛, 岩見 大基, 望月 端吾, 高田 徳容, 佐藤 択矢, 村橋 範浩, 平野 哲夫, 富樫 正樹
日本泌尿器科学会雑誌, 102, 2, 469, 469, 一般社団法人 日本泌尿器科学会, 2011
Japanese - Direct targeting of fibroblast growth factor-inducible 14 protein protects against renal ischemia reperfusion injury.
Kiyohiko Hotta, Masayuki Sho, Ichiro Yamato, Keiji Shimada, Hiroshi Harada, Takahiro Akahori, Shinji Nakamura, Noboru Konishi, Hideo Yagita, Katsuya Nonomura, Yoshiyuki Nakajima
Kidney international, 79, 2, 179, 88, Jan. 2011, [Peer-reviewed], [International Magazine]
English, Scientific journal - Therapeutic potential of the TWEAK/Fn14 pathway in intractable gastrointestinal cancer.
Ryo Yoriki, Satoru Akashi, Masayuki Sho, Takeo Nomi, Ichiro Yamato, Kiyohiko Hotta, Tomoyoshi Takayama, Sohei Matsumoto, Kohei Wakatsuki, Kazuhiro Migita, Hideo Yagita, Yoshiyuki Nakajima
Experimental and therapeutic medicine, 2, 1, 103, 108, Jan. 2011, [Peer-reviewed], [International Magazine]
English, Scientific journal - 生体腎移植レシピエントの移植前の精神状態とドナーに対する否定的認知の関連
本谷 亮, 金澤 潤一郎, 安藤 孟梓, 高垣 耕企, 関口 真有, 佐藤 真澄, 原田 浩, 堀田 記世彦, 坂野 雄二, 平野 哲夫
日本行動療法学会大会発表論文集, 36回, 308, 309, (一社)日本認知・行動療法学会, Dec. 2010
Japanese - 生体腎移植レシピエントの移植前の精神的健康とソーシャルサポート及び対処方略との関連
関口 真有, 金澤 潤一郎, 本谷 亮, 高垣 耕企, 安藤 孟梓, 佐藤 真澄, 原田 浩, 堀田 記世彦, 坂野 雄二, 平野 哲夫
日本行動療法学会大会発表論文集, 36回, 312, 313, (一社)日本認知・行動療法学会, Dec. 2010
Japanese - 鏡視下腎摘除術後に大量リンパ漏による循環不全にて死亡した1例
望月 端吾, 岩見 大基, 堀田 記世彦, 村橋 範浩, 高田 徳容, 関 利盛, 原田 浩
Japanese Journal of Endourology and ESWL, 23, 3, 242, 242, (一社)日本泌尿器内視鏡学会, Oct. 2010
Japanese - 腎移植後ステロイド早期離脱療法の中期成績
三浦 正義, 原田 浩, 下田 直彦, 伊藤 洋輔, 土橋 誠一郎, 福澤 信之, 堀田 記世彦, 岩見 大基, 森田 研, 野々村 克也, 玉置 透
移植, 45, 総会臨時, 237, 237, (一社)日本移植学会, Oct. 2010
Japanese - 腎移植後早期貧血の検討
三浦 正義, 原田 浩, 堀田 記世彦, 下田 直彦, 福澤 信之, 岩見 大基, 森田 研, 伊藤 洋輔, 土橋 誠一郎, 野々村 克也, 玉置 透
移植, 45, 総会臨時, 258, 258, (一社)日本移植学会, Oct. 2010
Japanese - OGTTによる腎移植前後の耐糖能評価およびCNIの変更による改善効果
原田 浩, 堀田 記世彦, 岩見 大基, 三浦 正義, 下田 直彦, 関 利盛, 富樫 正樹
移植, 45, 総会臨時, 259, 259, (一社)日本移植学会, Oct. 2010
Japanese - サイトメガロウイルス抗体陽性レシピエントにおける免疫抑制法別の感染頻度の検討
三浦 正義, 原田 浩, 堀田 記世彦, 土橋 誠一郎, 伊藤 洋輔, 岩見 大基, 福澤 信之, 下田 直彦, 森田 研, 野々村 克也, 玉置 透
移植, 45, 総会臨時, 338, 338, (一社)日本移植学会, Oct. 2010
Japanese - A case of pregnancy-induced thrombotic thrombocytopenic purpura with a kidney allograft recipient.
Daiki Iwami, Hiroshi Harada, Kiyohiko Hotta, Masayoshi Miura, Toshimori Seki, Masaki Togashi, Tetsuo Hirano
Clinical transplantation, 24 Suppl 22, 66, 9, Jul. 2010, [Peer-reviewed], [International Magazine]
English, Scientific journal - 抗ドナー抗体陽性生体腎移植後早期の急性抗体関連拒絶の治療に苦慮した1例
岩見 大基, 森田 研, 堀田 記世彦, 下田 直彦, 野々村 克也, 三浦 正義, 渡井 至彦
泌尿器外科, 23, 4, 629, 629, 医学図書出版(株), Apr. 2010
Japanese - 尿路異常に起因する腎不全に対する小児腎移植患者の成績
岩見 大基, 森田 研, 堀田 記世彦, 下田 直彦, 野々村 克也
泌尿器外科, 23, 4, 638, 638, 医学図書出版(株), Apr. 2010
Japanese - 長期透析患者の腎移植における尿路合併症についての検討
堀田 記世彦, 森田 研, 下田 直彦, 岩見 大基, 野々村 克也, 三浦 正義, 原田 浩, 平野 哲夫
泌尿器外科, 23, 4, 643, 643, 医学図書出版(株), Apr. 2010
Japanese - Clinical significance of prostate stem cell antigen expression in non-small cell lung cancer.
Takeshi Kawaguchi, Masayuki Sho, Takashi Tojo, Ichiro Yamato, Takeo Nomi, Kiyohiko Hotta, Kaoru Hamada, Yasue Suzaki, Shigeki Sugiura, Keiji Kushibe, Yoshiyuki Nakajima, Shigeki Taniguchi
Japanese journal of clinical oncology, 40, 4, 319, 26, Apr. 2010, [Peer-reviewed], [International Magazine]
English, Scientific journal - BKウイルス尿管膀胱炎の発症が疑われた献腎移植症例
岩見 大基, 原田 浩, 堀田 記世彦, 中村 美智子, 三浦 正義, 関 利盛, 平野 哲夫, 富樫 正樹
腎移植・血管外科, 21, 1, 47, 52, 腎移植・血管外科研究会, Dec. 2009
Japanese - Clinical importance of B7-H3 expression in human pancreatic cancer
I. Yamato, M. Sho, T. Nomi, T. Akahori, K. Shimada, K. Hotta, H. Kanehiro, N. Konishi, H. Yagita, Y. Nakajima
BRITISH JOURNAL OF CANCER, 101, 10, 1709, 1716, Nov. 2009, [Peer-reviewed]
English, Scientific journal - 抗ドナー抗体陽性腎移植の臨床的検討
下田 直彦, 三浦 正義, 原田 浩, 福澤 信之, 田邉 起, 岩見 大基, 堀田 記世彦, 野々村 克也
移植, 44, 総会臨時, 281, 281, (一社)日本移植学会, Sep. 2009
Japanese - 当施設における高齢者腎移植の検討
福澤 信之, 三浦 正義, 下田 直彦, 堀田 記世彦, 田邊 起, 野々村 克也, 岩見 大基, 原田 浩
移植, 44, 総会臨時, 287, 287, (一社)日本移植学会, Sep. 2009
Japanese - Pediatric kidney transplantation is safe and available for patients with urological anomalies as well as those with primary renal diseases.
Ken Morita, Daiki Iwami, Kiyohiko Hotta, Naohiko Shimoda, Masayoshi Miura, Yoshihiko Watarai, Sakurako Hoshii, Katsuyuki Obikane, Taiji Nakashima, Satoshi Sasaki, Katsuya Nonomura
Pediatric transplantation, 13, 2, 200, 5, Mar. 2009, [Peer-reviewed], [International Magazine]
English, Scientific journal - OP-269 腎移植前後の糖代謝異常についての検討(腎移植2,一般演題口演,第97回日本泌尿器科学会総会)
下田 直彦, 三浦 正義, 原田 浩, 福澤 信之, 堀田 記世彦, 中村 美智子, 諸岡 加奈子, 平野 哲矢, 野々村 克也
日本泌尿器科学会雑誌, 100, 2, 256, 256, 一般社団法人 日本泌尿器科学会, 2009
Japanese - OP-272 血液型不適合腎移植における急性抗体関連型拒絶反応のrisk factorの検討(腎移植3,一般演題口演,第97回日本泌尿器科学会総会)
堀田 記世彦, 三浦 正義, 原田 浩, 下田 直彦, 福澤 信之, 中村 美智子, 平野 哲夫, 野々村 克也
日本泌尿器科学会雑誌, 100, 2, 256, 256, 一般社団法人 日本泌尿器科学会, 2009
Japanese - サイトメガロウイルス抗体陰性症例に対するバルガンシクロビル予防投与の臨床的検討
三浦 正義, 下田 直彦, 諸岡 加奈子, 原田 浩, 岩見 大基, 堀田 記世彦, 平野 哲夫, 野々村 克也
移植, 43, 総会臨時, 312, 312, (一社)日本移植学会, Sep. 2008
Japanese - 移植後新規発生糖尿病のためのタクロリムスをシクロスポリンに変更した8症例の検討
下田 直彦, 三浦 正義, 福澤 信之, 堀田 記世彦, 岩見 大基, 野々村 克也
移植, 43, 総会臨時, 324, 324, (一社)日本移植学会, Sep. 2008
Japanese - 腎移植前後の糖代謝異常についての検討
下田 直彦, 三浦 正義, 原田 浩, 福澤 信之, 堀田 記世彦, 岩見 大基, 平野 哲夫, 野々村 克也
移植, 43, 総会臨時, 329, 329, (一社)日本移植学会, Sep. 2008
Japanese - Valganciclovir(VGCV)による予防投与を行った小児腎移植2例の検討
下田 直彦, 堀田 記世彦, 岩見 大基, 森田 研, 野々村 克也
日本小児腎不全学会雑誌, 28, 149, 150, 日本小児腎不全学会, Aug. 2008
Japanese - PP-209 腹腔鏡下副腎摘出術を施行した副腎エキノコックス症の1例(副腎・後腹膜,一般演題ポスター,第96回日本泌尿器科学会総会)
石川 修平, 原林 透, 篠原 信雄, 安部 崇重, 堀田 記世彦, 望月 端吾, 菅野 由岐子, 佐々木 元, 野々村 克也
日本泌尿器科学会雑誌, 99, 2, 430, 430, 一般社団法人 日本泌尿器科学会, 2008
Japanese - 長期の免疫抑制により可能になった高抗体価血液型不適合生体腎移植
堀田 記世彦, 森田 研, 下田 直彦, 岩見 大基, 野々村 克也
腎移植・血管外科, 19, 1, 72, 76, 腎移植・血管外科研究会, Dec. 2007
Japanese - 抗ドナー抗体陽性生体腎移植後早期の急性抗体関連拒絶の治療に難渋した1例
岩見 大基, 三浦 正義, 堀田 記世彦, 下田 直彦, 森田 研, 渡井 至彦, 久保田 佳奈子, 伊藤 智雄, 野々村 克也
腎移植・血管外科, 19, 1, 96, 101, 腎移植・血管外科研究会, Dec. 2007
Japanese - The difference in histopathology of antibody-mediated rejection between ABO incompatible and pre-sensitized cases
Naohiko Shimoda, Masayoshi Miura, Kanako C. Kubota, Kiyohiko Hotta, Daiki Iwami, Tomoo Itoh, Ken Morita, Yoshihiko Watarai, Katsuya Nonomura
CLINICAL TRANSPLANTATION, 21, 13, 17, Jul. 2007, [Peer-reviewed]
English, Scientific journal - 生体腎移植を断念した症例の検討
森田 研, 下田 直彦, 岩見 大基, 堀田 記世彦, 野々村 克也
日本透析医学会雑誌, 40, Suppl.1, 505, 505, (一社)日本透析医学会, May 2007
Japanese - 長期透析患者の腎移植における尿路合併症の検討
三浦 正義, 堀田 記世彦, 原田 浩, 諸岡 加奈子, 下田 直彦, 岩見 大基, 森田 研, 関 利盛, 富樫 正樹, 野々村 克也, 平野 哲夫
日本透析医学会雑誌, 40, Suppl.1, 507, 507, (一社)日本透析医学会, May 2007
Japanese - Cytomegalovirus(CMV)抗体陰性例への感染予防の検討
岩見 大基, 堀田 記世彦, 下田 直彦, 森田 研, 野々村 克也
移植, 42, 2, 175, 175, (一社)日本移植学会, Apr. 2007
Japanese - OP-006 尿路異常を合併した小児腎移植患者の成績について(第95回日本泌尿器科学会総会)
岩見 大基, 森田 研, 堀田 記世彦, 下田 直彦, 野々村 克也
日本泌尿器科学会雑誌, 98, 2, 292, 292, 一般社団法人 日本泌尿器科学会, 2007
Japanese - OP-222 長期透析患者の腎移植における尿路合併症についての検討(第95回日本泌尿器科学会総会)
堀田 記世彦, 岩見 大基, 下田 直彦, 三浦 正義, 森田 研, 渡井 至彦, 原田 浩, 平野 哲夫, 野々村 克也
日本泌尿器科学会雑誌, 98, 2, 346, 346, 一般社団法人 日本泌尿器科学会, 2007
Japanese - OP-061 後腹膜腔に発生した悪性リンパ腫の検討(一般演題口演,第94回日本泌尿器科学会総会)
堀田 記世彦, 原田 浩, 小川 弥生, 中村 美智子, 谷口 明久, 関 利盛, 平野 哲夫, 富樫 正樹
日本泌尿器科学会雑誌, 97, 2, 296, 296, 一般社団法人 日本泌尿器科学会, 2006
Japanese - AVP-001 後腹膜鏡補助腎部分切除術の経験(総会賞応募ビデオ,第94回日本泌尿器科学会総会)
関 利盛, 堀田 記世彦, 中村 美智子, 谷口 明久, 富樫 正樹, 原田 浩, 平野 哲夫
日本泌尿器科学会雑誌, 97, 2, 211, 211, 一般社団法人 日本泌尿器科学会, 2006
Japanese - 腎細胞癌に対する腎部分切除術の長期成績(第93回日本泌尿器科学会総会)
石川 隆太, 堀田 記世彦, 藤本 浩明, 佐々木 芳浩, 坂下 茂夫
日本泌尿器科学会雑誌, 96, 2, 281, 281, 一般社団法人 日本泌尿器科学会, 2005
Japanese - 腎細胞癌術後の骨転移の検討 : 肺転移と比較して(第93回日本泌尿器科学会総会)
藤本 浩明, 堀田 記世彦, 石川 隆太, 佐々木 芳浩, 坂下 茂夫
日本泌尿器科学会雑誌, 96, 2, 203, 203, 一般社団法人 日本泌尿器科学会, 2005
Japanese - PP3-054 若年性尿路上皮腫瘍の一例(一般演題(ポスター))
堀田 記世彦, 石川 隆太, 丸山 覚, 菅野 貴行, 佐澤 陽, 村雲 雅志, 小柳 知彦, 高橋 達郎
日本泌尿器科学会雑誌, 95, 2, 487, 487, 一般社団法人 日本泌尿器科学会, 2004
Japanese
Other Activities and Achievements
- Current status of ABO incompatible kidney transplantation in Japan: Based on statistical data of renal transplantation in Japan.
Yuki Nakagawa, Makiko Mieno, Daiki Ogasa, Naotsugu Ichimaru, Hayato Hayato Nishida, Michio Nakamura, Kiyohiko Hotta, Kazuya Omoto, Masayuki Tasaki, Taihei Ito, Masayoshi Okumi, Motoro Araki, Takashi Kenmochi, Shigeo Horie, TRANSPLANTATION, 108, 9S, Sep. 2024
English, Summary international conference - The development of the data correction method and feature extraction for the skill evaluation of practical laparoscopic surgical training
海老名光希, 安部崇重, YAN Lingbo, 堀田記世彦, 今雅史, 樋口まどか, 古御堂純, 岩原直也, 小水内俊介, 倉島庸, 菊地央, 松本隆児, 大澤崇宏, 村井祥代, 辻田哲平, 佐瀬一弥, CHEN Xiaoshuai, 妹尾拓, 篠原信雄, 近野敦, 日本機械学会ロボティクス・メカトロニクス講演会講演論文集(CD-ROM), 2023, 2023 - 本邦の腎移植の現状と課題
中川由紀, 中川由紀, 中川由紀, 小笠大起, 野崎大司, 三重野牧子, 市丸直嗣, 西田隼人, 中村道郎, 堀田記世彦, 尾本和也, 田崎正行, 伊藤泰平, 奥見雅由, 荒木元朗, 祖父江理, 山田保俊, 島袋修一, 剣持敬, 剣持敬, 湯沢賢治, 堀江重郎, 日本臨床腎移植学会雑誌, 11, 2, 2023 - 腹腔鏡手術における手術鉗子動態の教育利用・鉗子位置情報を用いた手術支援に関する基礎研究
安部崇重, 近野敦, 海老名光希, 晏凌波, 今雅史, 小水内俊介, 堀田記世彦, 渡辺雅彦, 七戸俊明, 倉島庸, 篠原信雄, 日本生体医工学会大会プログラム・抄録集(Web), 62nd, 2023 - 腎移植臨床登録集計報告(2022) 2021年実施症例の集計報告と追跡調査結果
中川 由紀, 三重野 牧子, 市丸 直嗣, 森田 研, 中村 道郎, 堀田 記世彦, 尾本 和也, 田崎 正行, 伊藤 泰平, 牛込 秀隆, 荒木 元朗, 祖父江 理, 山田 保俊, 島袋 修一, 剣持 敬, 湯沢 賢治, 日本臨床腎移植学会, 移植, 57, 3, 199, 219, Dec. 2022
(一社)日本移植学会, Japanese - 腹腔鏡手術トレーニングのための機械学習を用いた技能別スコア評価システムの開発
海老名光希, 安部崇重, 堀田記世彦, 樋口まどか, 古御堂純, 岩原直也, 今雅史, 小水内俊介, 倉島庸, 菊地央, 松本隆児, 大澤崇宏, 村井祥代, 辻田哲平, 佐瀬一弥, 陳暁帥, 篠原信雄, 近野敦, 日本ロボット学会学術講演会予稿集(CD-ROM), 40th, 2022 - 腎移植臨床登録集計報告(2021) 2020年実施症例の集計報告と追跡調査結果
中川 由紀, 三重野 牧子, 市丸 直嗣, 森田 研, 中村 道郎, 堀田 記世彦, 尾本 和也, 田崎 正行, 伊藤 泰平, 牛込 秀隆, 荒木 元朗, 祖父江 理, 山田 保俊, 島袋 修一, 剣持 敬, 湯沢 賢治, 日本臨床腎移植学会・日本移植学会, 移植, 56, 3, 195, 216, Dec. 2021
(一社)日本移植学会, Japanese - 【泌尿器科当直医マニュアル】外来編 緊急対応を要する疾患・トラブル 腎移植後患者の発熱・感染症
田邉 起, 堀田 記世彦, 臨床泌尿器科, 75, 4, 115, 118, Apr. 2021
(株)医学書院, Japanese - 機械学習を利用した鉗子動態特徴量に基づく腹腔鏡手術基本手技の技量評価
安部崇重, 海老名光希, 堀田記世彦, 古御堂純, 岩原直也, 今雅史, 樋口まどか, 小水内俊介, 倉島庸, 村井祥代, 近野敦, 篠原信雄, 日本泌尿器科学会総会(Web), 109th, 2021 - 左右差に左右されない当院の後腹膜鏡下生体腎ドナー採取術の安全性と有効性の検討
西田翔, 久保太郎, 南園京子, 片野咲, 須田遼祐, 堀田記世彦, 篠原信雄, 岩見大基, 日本泌尿器内視鏡学会(Web), 35th, 2021 - 腎移植臨床登録集計報告(2020)2019年実施症例の集計報告と追跡調査結果
八木澤 隆, 三重野 牧子, 市丸 直嗣, 森田 研, 中村 道郎, 堀田 記世彦, 剣持 敬, 湯沢 賢治, 日本臨床腎移植学会登録委員会, 移植, 55, 3, 225, 243, Dec. 2020
(一社)日本移植学会, Japanese - 【症例から学ぶ泌尿器疾患の見逃してはいけないサイン】(chapter 2)外来編 肉眼的血尿(随伴症状なし)
堀田 記世彦, Uro-Lo: 泌尿器Care & Cure, 25, 4, 470, 474, Aug. 2020
(株)メディカ出版, Japanese - 小児献腎移植の治療成績
堀田 記世彦, 岩見 大基, 岩原 直也, 篠原 信雄, 日本小児腎不全学会雑誌, 40, 135, 138, Jul. 2020
日本小児腎不全学会, Japanese - 免疫抑制療法の強化により改善したsubclinical antibody-mediated rejectionの1例
上條 千太, 氏橋 一紘, 堀田 記世彦, 岡田 宏美, 岩見 大基, 岩原 直也, 篠原 信雄, 日本小児腎不全学会雑誌, 40, 321, 324, Jul. 2020
日本小児腎不全学会, Japanese - MOTION ANALYSIS TO PROMOTE UNDERSTANDING OF LAPAROSCOPIC SURGERY-DEXTERITY AND OBJECTIVE ASSESSMENT-BASED SIMULATION TRAINING
Takashige Abe, Koki Ebina, Madoka Higuchi, Jun Furumido, Naoya Iwahara, Masafumi Kon, Kiyohiko Hotta, Shunsuke Komizunai, Yo Kurashima, Hiroshi Kikuchi, Ryuji Matsumoto, Takahiro Osawa, Sachiyo Murai, Atsushi Konno, Nobuo Shinohara, JOURNAL OF UROLOGY, 203, E686, E686, Apr. 2020
English, Summary international conference - 「運動制限時代」の腎移植前後の体組成変化-BIA法を用いた単施設の検討
原田浩, 原田浩, 中村美智子, 堀田記世彦, 岩見大基, 関利盛, 平野哲夫, 日本腎臓リハビリテーション学会学術集会プログラム・抄録集, 10th (Web), 2020 - 腎移植臨床登録集計報告(2019) 2018年実施症例の集計報告と追跡調査結果
八木澤 隆, 三重野 牧子, 市丸 直嗣, 森田 研, 中村 道郎, 堀田 記世彦, 剣持 敬, 湯沢 賢治, 日本臨床腎移植学会・日本移植学会, 移植, 54, 2-3, 61, 80, Nov. 2019
(一社)日本移植学会, Japanese - 泌尿器科領域におけるトラブルシューティング(第104回) 腎移植後の尿路合併症の対策
堀田 記世彦, 岩見 大基, 篠原 信雄, 泌尿器外科, 32, 7, 945, 947, Jul. 2019
医学図書出版(株), Japanese - 先天性下部尿路通過障害による末期腎不全に対する腎移植の長期成績
堀田 記世彦, 岩見 大基, 守屋 仁彦, 中村 美智子, 今 雅史, 岩原 直也, 篠原 信雄, 日本小児腎不全学会雑誌, 39, 92, 95, Jul. 2019
日本小児腎不全学会, Japanese - 先行的献腎移植を施行した小児症例
前田 啓介, 堀田 記世彦, 岩見 大基, 高橋 弘典, 守屋 仁彦, 中村 美智子, 今 雅史, 岩原 直也, 篠原 信雄, 日本小児腎不全学会雑誌, 39, 200, 202, Jul. 2019
日本小児腎不全学会, Japanese - 当科で行っているブタ臓器を用いた腹腔鏡手術トレーニングの紹介
安部 崇重, 樋口 まどか, 宮田 遥, 今 雅史, 堀田 記世彦, 森田 研, 菊池 央, 松本 隆児, 大澤 崇宏, 倉島 庸, 篠原 信雄, 泌尿器外科, 32, 7, 992, 992, Jul. 2019
医学図書出版(株), Japanese - 当科で行っているブタ臓器を用いた腹腔鏡手術トレーニングの紹介
安部 崇重, 樋口 まどか, 宮田 遥, 今 雅史, 堀田 記世彦, 森田 研, 菊池 央, 松本 隆児, 大澤 崇宏, 倉島 庸, 篠原 信雄, 泌尿器外科, 32, 7, 992, 992, Jul. 2019
医学図書出版(株), Japanese - Yersinia enterocolitica腸炎の診断に苦慮した腎移植後の1例
佐藤 泰征, 岡本 孝之, 堀田 記世彦, 岩見 大基, 上田 泰弘, 高橋 俊行, 林 麻子, 篠原 信雄, 日本小児腎臓病学会雑誌, 32, 1Suppl., 154, 154, May 2019
(一社)日本小児腎臓病学会, Japanese - Yersinia enterocolitica腸炎の診断に苦慮した腎移植後の1例
佐藤 泰征, 岡本 孝之, 堀田 記世彦, 岩見 大基, 上田 泰弘, 高橋 俊行, 林 麻子, 篠原 信雄, 日本小児腎臓病学会雑誌, 32, 1Suppl., 154, 154, May 2019
(一社)日本小児腎臓病学会, Japanese - ブタティッシュを用いた腹腔鏡手術トレーニングのアセスメントツールとしての有用性の報告
安部 崇重, 樋口 まどか, 宮田 遙, 今 雅史, 堀田 記世彦, 森田 研, 菊地 央, 松本 隆児, 大澤 崇宏, 倉島 庸, 村井 祥代, 篠原 信雄, 日本泌尿器科学会総会, 107回, AOP, 025, Apr. 2019
(一社)日本泌尿器科学会総会事務局, Japanese - 腎移植臨床登録集計報告(2018)2017年実施症例の集計報告と追跡調査結果
八木澤 隆, 三重野 牧子, 市丸 直嗣, 森田 研, 中村 道郎, 堀田 記世彦, 日本臨床腎移植学会, 日本移植学会, 移植, 53, 2-3, 89, 108, Nov. 2018
(一社)日本移植学会, Japanese - 腎移植後腎不全に対して在宅腹膜透析を導入したprune belly症候群の一例
高橋 俊行, 岡本 孝之, 岩見 大基, 堀田 記世彦, 林 麻子, 山崎 健史, 佐藤 泰征, 森田 研, 日本小児PD・HD研究会雑誌, 30, 77, 78, Oct. 2018
日本小児PD・HD研究会, Japanese - 【小児腎不全-移行期医療の管理】先天性腎尿路異常(CAKUT)管理の現況
堀田 記世彦, 守屋 仁彦, 森田 研, 岩見 大基, 篠原 信雄, 臨床透析, 34, 9, 1149, 1154, Aug. 2018
(株)日本メディカルセンター, Japanese - 小児腎移植における慢性抗体関連型拒絶反応治療後の長期成績の検討
堀田 記世彦, 岡田 宏美, 岩見 大基, 樋口 はるか, 高田 祐輔, 篠原 信雄, 日本小児腎不全学会雑誌, 38, 118, 122, Jul. 2018
日本小児腎不全学会, Japanese - 過去15年間に施行した小児先行的腎移植の検討
山崎 健史, 岡本 孝之, 佐藤 泰征, 林 麻子, 高橋 俊行, 堀田 記世彦, 岩見 大基, 森田 研, 篠原 信雄, 有賀 正, 日本小児腎不全学会雑誌, 38, 123, 125, Jul. 2018
日本小児腎不全学会, Japanese - 腎移植後腎不全に対して在宅腹膜透析を導入したprune belly症候群の1例
林 麻子, 岡本 孝之, 岩見 大基, 堀田 記世彦, 高橋 俊行, 山崎 健史, 佐藤 泰征, 森田 研, 篠原 信雄, 有賀 正, 日本小児腎不全学会雑誌, 38, 201, 203, Jul. 2018
日本小児腎不全学会, Japanese - 四肢麻痺の視神経脊髄炎に対し血漿交換療法(PE)を併用し歩行可能まで回復した一例
千葉裕基, 太田稔, 岡本花織, 松本剛直, 白井慎一, 加納崇裕, 佐々木秀直, 堀田記世彦, 石川康暢, 西尾妙織, 岩見大基, 篠原信雄, 日本透析医学会雑誌, 51, Supplement 1, 599, 28 May 2018
Japanese - 当院透析室におけるアクションカードの評価
吉田佳純, 千葉裕基, 石川康暢, 堀田記世彦, 岩見大基, 笠松美紀, 篠原信雄, 日本透析医学会雑誌, 51, Supplement 1, 950, 28 May 2018
Japanese - 当院透析室におけるアクションカードの評価
吉田 佳純, 千葉 裕基, 石川 康暢, 堀田 記世彦, 岩見 大基, 笠松 美紀, 篠原 信雄, 日本透析医学会雑誌, 51, Suppl.1, 950, 950, May 2018
(一社)日本透析医学会, Japanese - 【後期研修医がおさえておきたい泌尿器手術TOP30 適応判定と周術期管理】術前アセスメント
堀田 記世彦, 篠原 信雄, 泌尿器外科, 31, 特別号, 2, 7, Apr. 2018
医学図書出版(株), Japanese - 当院小児腹膜透析症例におけるカテーテル関連感染症の検討
佐藤泰征, 岡本孝之, 高橋俊行, 林麻子, 堀田記世彦, 岩見大基, 篠原信雄, 日本小児腎不全学会学術集会プログラム・抄録集, 40th, 2018 - 後腹膜アプローチ腹腔鏡下移植用腎採取術の提供側による成績比較
岩見大基, 堀田記世彦, 岩原直也, 篠原信雄, Japanese Journal of Endourology, 31, 3 (Web), 2018 - 球状塞栓物質による腎動脈塞栓後に生体腎移植をしたADPKDの1例
西尾妙織, 作原祐介, 田邊起, 堀田記世彦, 渥美達也, 日本臨床腎移植学会プログラム・抄録集, 51st, 145, 2018
Japanese - modified DFPPによるIgG除去能とフィブリノゲン保持効果の検討
岩見大基, 松本剛直, 堀田記世彦, 太田稔, 千葉裕基, 樋口はるか, 篠原信雄, 日本泌尿器科学会総会(Web), 106th, ROMBUNNO.OP‐204 (WEB ONLY), 2018
Japanese - 後腹膜アプローチ腹腔鏡下移植用腎採取術の提供側別の成績の比較
岩見大基, 堀田記世彦, 樋口はるか, 村西雄基, 篠原信雄, 日本臨床腎移植学会プログラム・抄録集, 51st, 170, 2018
Japanese - 移植腎機能廃絶後,拒絶反応が遷延し移植腎摘出に至った1例
樋口はるか, 堀田記世彦, 岩見大基, 高田祐輔, 篠原信雄, 日本臨床腎移植学会プログラム・抄録集, 51st, 260, 2018
Japanese - 腎移植時における多発性嚢胞腎に対する後腹膜鏡下腎摘術
堀田記世彦, 岩見大基, 古御堂純, 森田研, 望月端吾, 田邉起, 樋口はるか, 高田祐輔, 金川匡一, 篠原信雄, Japanese Journal of Endourology, 30, 3, 216, Nov. 2017
Japanese - 献腎移植後に前腕内シャントを閉鎖するも残存した動静脈瘻
森田 研, 千葉 博基, 広瀬 貴行, 佐々木 元, 田邉 起, 堀田 記世彦, 岩見 大基, 篠原 信雄, 腎移植・血管外科, 28, 1, 41, 44, Oct. 2017
腎移植・血管外科研究会, Japanese - OGTTを用いた小児腎移植症例の耐糖能異常の検討
岩見大基, 岡本孝之, 堀田記世彦, 樋口はるか, 篠原信雄, 日本移植学会総会プログラム抄録集, 53rd, 361, Aug. 2017
Japanese - 血液混合キメリズムによる腎移植後の免疫寛容の誘導
堀田記世彦, 堀田記世彦, 大浦哲, COSIMI A. Benedict, 河合達郎, 日本移植学会総会プログラム抄録集, 53rd, 252, Aug. 2017
Japanese - 臨床工学技士から見た臓器移植への関与
太田稔, 岡本花織, 千葉裕基, 松本剛直, 岩崎毅, 寒河江磨, 矢萩亮児, 法邑まなみ, 鴇田智久, 堀田記世彦, 岩見大基, 大岡智学, 嶋村剛, 日本移植学会総会プログラム抄録集, 53rd, 240, Aug. 2017
Japanese - 免疫抑制と免疫寛容誘導におけるCD40副刺激遮断の役割
大浦哲, 堀田記世彦, COSIMI Benedict, 河合達郎, 日本移植学会総会プログラム抄録集, 53rd, 253, Aug. 2017
Japanese - 腎移植における持ち込み糖尿性腎症の長期的推移の病理学的検討
堀田記世彦, 深澤雄一郎, 岡田宏美, 畑中佳奈子, 岩見大基, 和田吉生, 高田祐輔, 樋口はるか, 広瀬貴行, 佐々木元, 福澤信之, 原田浩, 篠原信雄, 泌尿器外科, 30, 7, 1202‐1203, 15 Jul. 2017
Japanese - ABO血液型不適合腎移植におけるrituximabの適正使用量とモニタリングの有用性
広瀬貴行, 岩見大基, 堀田記世彦, 佐々木元, 樋口はるか, 高田祐輔, 篠原信雄, 泌尿器外科, 30, 7, 1200, 15 Jul. 2017
Japanese - あなたは低体重腎不全児のタイムリーな移植コーディネートができていますか?―症例検討から最善の治療選択を学ぶ―低体重児腎移植の問題点―移植医の立場から
堀田記世彦, 岩見大基, 岡本孝之, 森田研, 篠原信雄, 日本小児腎不全学会雑誌, 37, 73, 77, Jul. 2017
日本小児腎不全学会, Japanese - 先天性ネフローゼ症候群の腎移植
広瀬貴行, 岩見大基, 森田研, 堀田記世彦, 佐々木元, 樋口はるか, 高田祐輔, 篠原信雄, 日本小児腎不全学会雑誌, 37, 124, 127, Jul. 2017
日本小児腎不全学会, Japanese - ナースに,ドクターに,勉強会で教えたくなる泌尿器診療Current Knowledge スライドがWEBで見られる! 第9回 腎移植と免疫抑制剤
堀田記世彦, 岩見大基, 篠原信雄, 泌尿器Care & Cure Uro‐Lo, 22, 3, 380, 385, Jun. 2017
(株)メディカ出版, Japanese - IMPAIRMENT OF GLUCOSE TOLERANCE AFTER PEDIATRIC KIDNEY TRANSPLANT IS ASSOCIATED WITH WORSE SYSTEMIC INSULIN SENSITIVITY RATHER THAN FALL IN INSULIN SECRETION CAUSED BY IMMUNOSUPPRESSIVE DRUGS.
D. Iwami, T. Okamoto, K. Hotta, H. Sasaki, T. Hirose, H. Higuchi, Y. Takada, N. Shinohara, PEDIATRIC TRANSPLANTATION, 21, 40, 40, May 2017
English, Summary international conference - FOUR CASES OF KIDNEY TRANSPLANTATION TO TREAT CONGENITAL NEPHROTIC SYNDROME.
T. Hirose, D. Iwami, K. Hotta, H. Sasaki, H. Higuchi, Y. Takada, N. Shinohara, PEDIATRIC TRANSPLANTATION, 21, 59, 60, May 2017
English, Summary international conference - 【心停止下献腎移植推進のために】北海道における献腎移植の適応
森田 研, 田邉 起, 佐々木 元, 広瀬 貴行, 樋口 はるか, 岩見 大基, 堀田 記世彦, 篠原 信雄, 腎移植・血管外科, 27, 2, 109, 114, Apr. 2017
腎移植・血管外科研究会, Japanese - Impairment of Glucose Tolerance After Pediatric Kidney Transplant Is Associated with Worse Systemic Insulin Sensitivity Rather Than Fall in Insulin Secretion
D. Iwami, K. Hotta, H. Sasaki, T. Hirose, H. Higuchi, Y. Takada, N. Shinohara, AMERICAN JOURNAL OF TRANSPLANTATION, 17, 769, 769, Apr. 2017
English, Summary international conference - Induction of Delayed Renal Allograft Tolerance Using Only Clinically Available Reagents in Non-Human Primates
K. Hotta, T. Oura, A. Dehnadi, S. Boskovic, M. Matsunami, I. Rosales, N. Smith, R. Colvin, A. Cosimi, T. Kawai, AMERICAN JOURNAL OF TRANSPLANTATION, 17, 280, 280, Apr. 2017
English, Summary international conference - Clinical Outcomes of Kidney Transplant Recipients by Steroid Early Withdraw Protocol with Basiliximab Induction
Y. Takada, K. Hotta, D. Iwami, H. Higuchi, T. Hirose, H. Sasaki, N. Shinohara, AMERICAN JOURNAL OF TRANSPLANTATION, 17, 576, 576, Apr. 2017
English, Summary international conference - Long-Term Clinical Outcomes of Kidney Transplant Recipients with Body-Size Mismatch Between Recipient and Donor
Y. Takada, D. Iwami, K. Hotta, K. Kanagawa, H. Higuchi, T. Hirose, H. Sasaki, N. Shinohara, AMERICAN JOURNAL OF TRANSPLANTATION, 17, 787, 788, Apr. 2017
English, Summary international conference - INDUCTION OF DELAYED RENAL ALLOGRAFT TOLERANCE WITH CLINICAL AVAILABLE REAGENTS IN NON-HUMAN PRIMATES
Kiyohiko Hotta, Tetsu Oura, Abbas Dehnadi, Gilles Benichou, A. Benedict Cosimi, Tatsuo Kawai, JOURNAL OF UROLOGY, 197, 4, E390, E390, Apr. 2017
English, Summary international conference - Activation of Inflammation Amplifier in Kidney Graft and Urinary Biomarker for Chronic Rejection
H. Higuchi, D. Iwami, K. Hotta, N. Shinohara, M. Murakami, AMERICAN JOURNAL OF TRANSPLANTATION, 17, 720, 720, Apr. 2017
English, Summary international conference - Retroperitoneoscopic Living Donor Nephrectomy Safely Secures Excellent Graft Function
T. Hirose, K. Hotta, D. Iwami, H. Sasaki, H. Higuchi, Y. Takada, N. Shinohara, AMERICAN JOURNAL OF TRANSPLANTATION, 17, 788, 788, Apr. 2017
English, Summary international conference - Dual Costimulatory Blockades Failed to Achieve Transplant Tolerance Despite Induction of Mixed Chimerism in NHPs
T. Oura, K. Hotta, I. Rosales, A. Dehnadi, J. Lei, J. James Markmann, M. Matsunami, J. Paster, I. Hanekamp, K. Pruner, K. Kawai, D. Ndishabandi, R. -N. Smith, B. Cosimi, T. Kawai, AMERICAN JOURNAL OF TRANSPLANTATION, 17, 344, 345, Apr. 2017
English, Summary international conference - Glucose Tolerance After Kideney Transplant Is Affected by Systemic Insulin Sensitivity Rather Than Usage of Tacrolimus
D. Iwami, A. Nakamura, K. Hotta, H. Sasaki, T. Hirose, H. Higuchi, Y. Takada, H. Miyoshi, N. Shinohara, AMERICAN JOURNAL OF TRANSPLANTATION, 17, 759, 759, Apr. 2017
English, Summary international conference - Percentage of CD19(+) B Cells as a Predictor of Acute Antibody-Mediated Rejection After Administration of Rituximab in ABO-Incompatible Kidney Transplantation
T. Hirose, D. Iwami, K. Hotta, H. Sasaki, H. Higuchi, N. Shinohara, AMERICAN JOURNAL OF TRANSPLANTATION, 17, 426, 426, Apr. 2017
English, Summary international conference - THE ACTIVATION OF INFLAMMATION AMPLIFIER IN KIDNEY TRANSPLANT GRAFT AND URINARY BIOMARKER FOR CHRONIC REJECTION
Haruka Higuchi, Daiki Iwami, Kiyohiko Hotta, Nobuo Shinohara, Masaaki Murakami, JOURNAL OF UROLOGY, 197, 4, E76, E76, Apr. 2017
English, Summary international conference - 【よりよい移植のための工夫-移植診療における小さくて大きい問題-】腎移植後の内シャント閉鎖手術の適応について
岩見 大基, 田邉 起, 堀田 記世彦, 樋口 はるか, 森田 研, 篠原 信雄, 腎移植・血管外科, 29, 2, 115, 119, 2017
腎移植・血管外科研究会, Japanese - 血液型抗原発現によるリンパ球クロスマッチ擬陽性について
岩見大基, 伊藤誠, 堀田記世彦, 佐々木元, 広瀬貴行, 高田祐輔, 篠原信雄, 日本臨床腎移植学会プログラム・抄録集, 50th, 194, 2017
Japanese - PBSCT後同一ドナーからの生体腎移植の長期経過例の報告
原田浩, 山本聡, 和田吉生, 福澤信之, 平野哲夫, 堀田記世彦, 日本臨床腎移植学会プログラム・抄録集, 50th, 197, 2017
Japanese - 【腎移植の底辺拡大と標準化】広大な北海道での献腎摘出の工夫
原田 浩, 堀田 記世彦, 福澤 信之, 腎移植・血管外科, 26, 2, 46, 51, Dec. 2016
腎移植・血管外科研究会, Japanese - 下部尿路異常レシピエントにおける腎移植と尿路治療のタイミング
森田 研, 佐々木 元, 岩見 大基, 堀田 記世彦, 守屋 仁彦, 篠原 信雄, 日本小児腎不全学会雑誌, 36, 89, 93, Jul. 2016
日本小児腎不全学会, Japanese - Immune Tolerance Monitoring in Renal Allograft Tolerance Induced by Transient Mixed Chimerism in Nonhuman Primates and Humans.
K. Hotta, T. Oura, K. Crisalli, D. Sachs, B. Cosim, T. Kawai, AMERICAN JOURNAL OF TRANSPLANTATION, 16, 726, 726, Jun. 2016
English, Summary international conference - Urinary Exosomal Annexin A1 Is a Predictive Biomarker of Post Kidney Transplant Complications.
H. Harada, T. Murakami, C. Yamamoto, K. Hotta, N. Fukuzawa, M. Mitsuhashi, AMERICAN JOURNAL OF TRANSPLANTATION, 16, 451, 452, Jun. 2016
English, Summary international conference - IL-10 Expression of In Vitro Activated B Cells as A Biomarker for B Cell Tolerance.
T. Oura, K. Hotta, K. Crisalli, B. Cosimi, T. Kawai, AMERICAN JOURNAL OF TRANSPLANTATION, 16, 726, 727, Jun. 2016
English, Summary international conference - The Property of Modulatory T Cells Generated by Mixed Lymphocyte Culture with CD154 Blockade
K. Hotta, T. Oura, B. Cosimi, T. Kawai, AMERICAN JOURNAL OF TRANSPLANTATION, 16, 413, 413, Jun. 2016
English, Summary international conference - 【移植医学の進歩と病理の役割】移植免疫の基礎 血液キメリズムによる免疫寛容の誘導
堀田 記世彦, 大浦 哲, 河合 達郎, 病理と臨床, 34, 2, 118, 123, Feb. 2016
(株)文光堂, Japanese - CONTINUOUS IL-2 EXPOSURE BREAKS RENAL ALLOGRAFT TOLERANCE INDUCED VIA MIXED CHIMERISM PROTOCOL IN NONHUMAN PRIMATES
Yohei Yamada, Neal Smith Rex, Kiyohiko Hotta, Tetsu Ohura, Svjetlan Boskovic, Joren Madsen, Robert Colvin, Gilles Benichou, Ben Cosimi, Tatsuo Kawai, TRANSPLANT INTERNATIONAL, 28, 124, 124, Nov. 2015
English, Summary international conference - 一次移植後の下大静脈閉塞により二次脳死腎移植が機能しなかった先天性ネフローゼ症候群による小児腎不全症例
森田 研, 樋口 はるか, 大石 悠一郎, 広瀬 貴行, 佐々木 元, 田邉 起, 堀田 記世彦, 岩見 大基, 篠原 信雄, 日本小児腎不全学会雑誌, 35, 188, 192, Jul. 2015
日本小児腎不全学会, Japanese - Immunosuppression With Anti-CD40 mAb and Rapamycin for Islet and Kidney Co-Transplantation in Nonhuman Primates
T. Oura, K. Hotta, J. Lei, J. Markmann, A. Dehnadi, G. Benichou, B. Cosimi, T. Kawai, AMERICAN JOURNAL OF TRANSPLANTATION, 15, May 2015
English, Summary international conference - Kidney Versus Islet Allograft Survival After Induction of Mixed Chimerism in Nonhuman Primates
T. Oura, D. Ko, J. O'Neil, S. Boskovic, O. Nadazdin, K. Hotta, K. Kawai, B. Cosimi, T. Kawai, AMERICAN JOURNAL OF TRANSPLANTATION, 15, May 2015
English, Summary international conference - Safety and efficacy of laparoscopic donor nephrectomy : A comparative study by operative time period
広瀬 貴行, 堀田 記世彦, 岩見 大基, 田邉 起, 佐々木 元, 大石 悠一郎, 樋口 はるか, 篠原 信雄, 森田 研, Japanese Journal of Endourology, 28, 1, 84, 88, Apr. 2015
Japanese Society of Endourology, Japanese - 【泌尿器科の手術看護パーフェクトマニュアル】(第2章)実践編 術式別の術中看護マニュアル 腎移植術
森田 研, 岩見 大基, 堀田 記世彦, 中野 友裕, 大久保 るみ, 田中 真美, 山本 裕子, 芳賀 真理子, オペナーシング, 2015臨時増刊 泌尿器科の手術看護パーフェクトマニュアル, 157, 171, Mar. 2015
(株)メディカ出版, Japanese - Suppression of CD8(+) Memory T Cell Proliferation and Expansion of T Regulatory Cells By Bone Marrow Derived Autologous Mesenchymal Stem Cells in Nonhuman Primates.
T. Oura, K. Hotta, B. Cosimi, G. Benichou, T. Kawai, TRANSPLANTATION, 98, 43, 43, Jul. 2014
English, Summary international conference - Suppression of CD8(+) Memory T Cell Proliferation and Expansion of T Regulatory Cells By Bone Marrow Derived Autologous Mesenchymal Stem Cells in Nonhuman Primates
T. Oura, K. Hotta, B. Cosimi, G. Benichou, T. Kawai, AMERICAN JOURNAL OF TRANSPLANTATION, 14, 43, 43, Jun. 2014
English, Summary international conference - 転移を有する腎癌pT1a症例の検討
高田 祐輔, 内野 秀紀, 佐々木 元, 佐澤 陽, 堀田 記世彦, 大石 悠一郎, 今 雅史, 石崎 淳司, 高田 徳容, 原田 浩, 関 利盛, 富樫 正樹, 坂下 茂夫, 泌尿器外科, 27, 2, 250, 250, Feb. 2014
医学図書出版(株), Japanese - 市立札幌病院における腎移植500症例の臨床的検討
原田 浩, 堀田 記世彦, 福澤 信之, 佐々木 元, 中村 美智子, 高田 祐輔, 高田 徳容, 今 雅史, 石崎 淳司, 望月 端吾, 千葉 博基, 川口 愛, 田中 博, 関 利盛, 富樫 正樹, 平野 哲夫, 泌尿器外科, 27, 2, 258, 258, Feb. 2014
医学図書出版(株), Japanese - 腎細胞癌pT1a症例の遠隔転移危険因子
高田 祐輔, 佐澤 陽, 内野 秀紀, 大石 悠一郎, 坂下 茂夫, 佐々木 元, 堀田 記世彦, 関 利盛, 富樫 正樹, 西日本泌尿器科, 76, 1, 1, 4, Jan. 2014
西日本泌尿器科学会, Japanese - ML-2.「腎移植とアフェレシス」抗ドナー抗体(DSA)陽性腎移植における抗体除去療法と脱感作療法の変遷(一般演題,日本アフェレシス学会第33回北海道地方会抄録)
森田 研, 広瀬 貴行, 田邉 起, 堀田 記世彦, 野々村 克也, 日本アフェレシス学会雑誌, 33, 1, 67, 68, 2014
日本アフェレシス学会, Japanese - 当院における尿路上皮癌に対するGC療法の検討
石崎淳司, 高田祐輔, 今雅史, 佐々木元, 堀田記世彦, 高田徳容, 原田浩, 平野哲夫, 関利盛, 富樫正樹, 泌尿器外科, 26, 12, 1867, 15 Dec. 2013
Japanese - 腎移植患者における自己腎癌の検討
佐々木元, 堀田記世彦, 和田吉生, 高田祐輔, 今雅史, 石崎淳司, 高田徳容, 平野哲夫, 関利盛, 富樫正樹, 原田浩, 泌尿器外科, 26, 12, 1855, 15 Dec. 2013
Japanese - 婦人科術後尿瘻に対する治療経験
関利盛, 高田祐輔, 今雅史, 石崎淳志, 佐々木元, 高田徳容, 富樫正樹, 和田吉生, 堀田記世彦, 原田浩, 平野哲夫, 泌尿器外科, 26, 12, 1855, 15 Dec. 2013
Japanese - 腎悪性腫瘍との鑑別が困難だったIgG4関連硬化性疾患の一例
今雅史, 高田祐輔, 佐々木元, 石崎淳司, 堀田記世彦, 高田徳容, 原田浩, 平野哲夫, 関利盛, 富樫正樹, 深澤雄一郎, 泌尿器外科, 26, 12, 1853, 15 Dec. 2013
Japanese - 若年者に発症した尿路上皮肉芽腫の1例
高田祐輔, 今雅史, 石崎淳司, 佐々木元, 高田徳容, 関利盛, 富樫正樹, 堀田記世彦, 原田浩, 平野哲夫, 柳内充, 深澤雄一郎, 泌尿器外科, 26, 12, 1860, 15 Dec. 2013
Japanese - 当院における二分脊椎症患者の排尿管理の検討
今雅史, 高田祐輔, 佐々木元, 石崎淳司, 堀田記世彦, 高田徳容, 原田浩, 平野哲夫, 関利盛, 富樫正樹, 泌尿器外科, 26, 12, 1865, 15 Dec. 2013
Japanese - 当院における鏡視下両側副腎摘除術の経験
石崎淳司, 高田祐輔, 今雅史, 佐々木元, 堀田記世彦, 高田徳容, 原田浩, 平野哲夫, 関利盛, 富樫正樹, 和田典男, 深澤雄一郎, 泌尿器外科, 26, 12, 1861, 15 Dec. 2013
Japanese - 膀胱褐色細胞腫の2例
千葉智市, 高田祐輔, 今雅史, 石崎淳司, 佐々木元, 堀田記世彦, 高田徳容, 原田浩, 関利盛, 富樫正樹, 泌尿器外科, 26, 12, 1863, 15 Dec. 2013
Japanese - 当科におけるBKウィルス腎症の検討
佐々木元, 堀田記世彦, 高田徳容, 石崎淳司, 今雅文, 高田祐輔, 関利盛, 富樫正樹, 原田浩, 泌尿器外科, 26, 12, 1865, 15 Dec. 2013
Japanese - Baseline Biopsy in Kidney Transplantation
田邉起, 堀田記世彦, 藤田裕美, 畑中佳奈子, 広瀬貴行, 佐々木元, 森田研, 野々村克也, 日本臨床腎移植学会雑誌, 1, 2, 175, 179, Dec. 2013
(一社)日本臨床腎移植学会, Japanese - タクロリムス徐放製剤1日2回投与法による小児腎移植後免疫抑制の治療的薬剤モニタリング
森田 研, 広瀬 貴行, 田邉 起, 堀田 記世彦, 岩見 大基, 野々村 克也, 今日の移植, 26, 6, 574, 576, Nov. 2013
(株)日本医学館, Japanese - A single low dose rituximab ensures excellent outcome of ABO incompatible kidney transplantation
Hiroshi Harada, Hajime Sasaki, Kiyohiko Hotta, Yuichiro Oishi, Haruka Higuchi, Ai Kawaguchi, Toshimori Seki, Masaki Togashi, Tetsuo Hirano, Nobuyuki Fukuzawa, XENOTRANSPLANTATION, 20, 5, 320, 320, Sep. 2013
English, Summary international conference - 腎移植後に尿路再建手術を施行した小児慢性腎不全の2例
広瀬 貴行, 森田 研, 堀田 記世彦, 福澤 信之, 田邊 起, 青柳 俊紀, 橘田 岳也, 三井 貴彦, 守屋 仁彦, 野々村 克也, 日本小児腎不全学会雑誌, 33, 96, 98, Jul. 2013
日本小児腎不全学会, Japanese - Once-Daily Extended-Release Formulation of Tacrolimus Does Not Require Double Dose of Twice-Daily Formulation of Tacrolimus in Kidney Transplantation.
H. Harada, N. Fukuzawa, K. Hotta, T. Seki, M. Togashi, AMERICAN JOURNAL OF TRANSPLANTATION, 13, 315, 315, Apr. 2013
English, Summary international conference - HBs抗原陽性ドナーからの生体腎移植を行ったHBs抗原陽性症例
原田 浩, 堀田 記世彦, 佐々木 元, 高田 祐輔, 今 雅史, 石崎 淳司, 高田 徳容, 平野 哲夫, 関 利盛, 富樫 正樹, 酒井 謙, 腎移植・血管外科, 24, 2, 165, 169, Mar. 2013
腎移植・血管外科研究会, Japanese - 胸腹部大動脈置換と3分枝(両側腎動脈、腹腔動脈)再建後に、左腎動脈狭窄を生じ自家腎移植を行ったmiddle aortic syndromeの男児例
森田 研, 福澤 信之, 岩見 大基, 堀田 記世彦, 田邊 起, 篠原 信雄, 野々村 克也, 橘 剛, 松居 喜郎, 腎移植・血管外科, 24, 1, 58, 61, Dec. 2012
腎移植・血管外科研究会, Japanese - 特発性血小板減少性紫斑病を合併した慢性腎不全患者に施行した生体腎移植の2症例
堀田 記世彦, 内山 結理, 佐々木 元, 福澤 信之, 関 利盛, 富樫 正樹, 原田 浩, 腎移植・血管外科, 24, 1, 82, 87, Dec. 2012
腎移植・血管外科研究会, Japanese - 腎動静脈瘻に対する治療経験
関 利盛, 高田 祐輔, 今 雅史, 石崎 淳司, 佐々木 元, 高田 徳容, 富樫 正樹, 堀田 記世彦, 原田 浩, 臼渕 浩明, 腎移植・血管外科, 24, 1, 30, 34, Dec. 2012
腎移植・血管外科研究会, Japanese - 転移を有する腎癌pT1a症例の検討
高田 祐輔, 内野 秀紀, 佐々木 元, 堀田 記世彦, 佐澤 陽, 大石 悠一郎, 今 雅史, 石崎 淳司, 高田 徳容, 原田 浩, 関 利盛, 富樫 正樹, 坂下 茂夫, 西日本泌尿器科, 74, 増刊, 125, 125, Oct. 2012
西日本泌尿器科学会, Japanese - LAPAROSCOPIC DONOR NEPHRECTOMY: SAPPORO CITY GENERAL HOSPITAL EXPERIENCE
Toshimori Seki, Hiroshi Harada, Kiyohiko Hotta, Masayoshi Miura, Norikata Takada, Daiki Iwami, Tango Mochizuki, Nobuyuki Fukuzawa, Hajime Sasaki, Masaki Togashi, JOURNAL OF ENDOUROLOGY, 26, A123, A123, Sep. 2012
English, Summary international conference - 【腎疾患治療マニュアル2012-13】泌尿器科疾患 腎血管疾患(腎梗塞、動静脈瘻、動脈瘤)
堀田 記世彦, 臼渕 浩明, 原田 浩, 腎と透析, 72, 増刊, 507, 511, May 2012
(株)東京医学社, Japanese - Contracted Bladder Increased the Risk of Urological Complications after Kidney Transplantation; a Single Center Experience
K. Hotta, H. Sasaki, T. Seki, N. Takada, J. Ishizaki, M. Kon, Y. Takada, T. Hirano, M. Togashi, H. Harada, AMERICAN JOURNAL OF TRANSPLANTATION, 12, 536, 536, May 2012
English, Summary international conference - Low Dose Rituximab Is Sufficient for Successful ABO-Incompatible Kidney Transplantation
H. Sasaki, K. Hotta, Y. Takada, M. Kon, J. Ishizaki, N. Takada, T. Seki, M. Togashi, H. Harada, AMERICAN JOURNAL OF TRANSPLANTATION, 12, 230, 230, May 2012
English, Summary international conference - 腎移植症例における移植腎盂腎炎の検討
佐々木 元, 堀田 記世彦, 和田 吉生, 高田 祐輔, 今 雅史, 石崎 淳司, 高田 徳容, 平野 哲夫, 関 利盛, 富樫 正樹, 原田 浩, 泌尿器外科, 25, 臨増, 1096, 1096, May 2012
医学図書出版(株), Japanese - 腎悪性腫瘍との鑑別が困難だったIgG4関連硬化性疾患の一例
今 雅史, 高田 祐輔, 佐々木 元, 石崎 淳司, 堀田 記世彦, 高田 徳容, 原田 浩, 平野 哲夫, 関 利盛, 富樫 正樹, 深澤 雄一郎, 泌尿器外科, 25, 臨増, 1107, 1107, May 2012
医学図書出版(株), Japanese - 当院における鏡視下両側副腎摘除術の経験
石崎 淳司, 高田 祐輔, 今 雅史, 佐々木 元, 堀田 記世彦, 高田 徳容, 平野 哲夫, 原田 浩, 関 利盛, 富樫 正樹, 和田 典男, 深澤 雄一郎, 泌尿器外科, 25, 臨増, 1112, 1112, May 2012
医学図書出版(株), Japanese - 若年者に発症した尿路上皮肉芽腫の1例
高田 祐輔, 今 雅史, 佐々木 元, 石崎 淳司, 高田 徳容, 関 利盛, 富樫 正樹, 和田 吉生, 堀田 記世彦, 平野 哲夫, 原田 浩, 柳内 充, 深澤 雄一郎, 泌尿器外科, 25, 臨増, 1116, 1116, May 2012
医学図書出版(株), Japanese - 遠隔転移を来した腎細胞癌の臨床的検討
高田 徳容, 高田 祐輔, 今 雅史, 石崎 淳司, 佐々木 元, 堀田 記世彦, 平野 哲夫, 原田 浩, 関 利盛, 富樫 正樹, 泌尿器外科, 25, 臨増, 1141, 1141, May 2012
医学図書出版(株), Japanese - CLINICAL SIGNIFICANCE OF PROSTATE CANCER ANTIGEN-1 IN RENAL CELL CARCINOMA
Kiyohiko Hotta, Masayuki Sho, Keiji Shimada, Kiyohide Fujimoto, Kazutake Tsujikawa, Ichiro Yamato, Hiroshi Harada, Noboru Konishi, Yoshiyuki Hirao, Yoshiyuki Nakajima, Katsuya Nonomura, JOURNAL OF UROLOGY, 187, 4, E176, E176, Apr. 2012
English, Summary international conference - SIGNIFICANCE AND THERAPEUTIC POTENTIAL OF TARGETING DELTA-LIKE 4 IN RENAL ISCHEMIA REPERFUSION INJURY
Kiyohiko Hotta, Masayuki Sho, Ichiro Yamato, Hiroshi Harada, Hideo Yagita, Yoshiyuki Nakajima, Katsuya Nonomura, JOURNAL OF UROLOGY, 187, 4, E912, E913, Apr. 2012
English, Summary international conference - Epstein-Barr virus陰性の腎移植後リンパ球増殖性疾患の1例
和田 吉生, 堀田 記世彦, 高田 祐輔, 市立札幌病院医誌 = Acta medica nosocomi Sapporo = The Journal of Sapporo City General Hospital, 71, 2, 79, 83, 31 Mar. 2012
移植後リンパ球増殖性疾患(PTLD)は、多くの症例でEpstein-Barr virus(EBV)の初感染あるいは再活性化が関与していることが知られている。しかし、今回EBVの関与が証明されなかったPTLDを経験したため、ここに報告する。症例は64歳の男性で、7年間の血液透析を経て、妻をドナーとした生体腎移植が施行された。免疫抑制薬はシクロスポリン/ミコフェノール酸モフェチル(MMF)/プレドニゾロンの3剤で導入され、以後の経過は良好であった。移植46ヶ月後に右下腹部痛が出現し、造影CTを施行したところ、移植腎上極に長径15cmの腫瘍を認めた。経皮的針生検を施行し、びまん性大細胞型B細胞性リンパ腫と診断された。EBER(EBV-encoded RNA)染色は陰性、EBV-DNAも陰性であり、EBVの関与は証明されなかった。MMFを中止し、R-CHOP(リツキシマブ、シクロフォスファミド、ドキソルビシン、ビンクリスチン、メチルプレドニゾロンによる抗がん剤治療)を6コース施行して完全寛解となった。以後、移植腎機能を喪失することなく、安定して推移している。, 市立札幌病院, Japanese - 移植後早期に再発したIgA腎症の1例
平田 裕哉, 堀田 記世彦, 深澤 雄一郎, 市立札幌病院医誌 = Acta medica nosocomi Sapporo = The Journal of Sapporo City General Hospital, 71, 2, 75, 78, 31 Mar. 2012
症例は43歳、男性。IgA腎症による慢性腎不全にて16年間の血液透析を経て、生体腎移植を施行した(ドナー：45歳の姉、血液型適合(O型)、HLA：4ミスマッチ)。免疫抑制剤はバジリキシマブ、タクロリムス、ミコフェノール酸モフェチル、メチルプレドニゾロン(MPZ)の4剤で導入しMPZは3日間で中止した。移植後は即座に利尿がみられ、移植後4日目には血清クレアチニン(Cre)1.62mg/dlまで低下した。しかし、移植後9日目にCre1.85mg/dlと上昇し、腎生検したところボーダーラインチェンジの所見であった。MPZ、500mg/日を3日間施行し、Cre 1.45mg/dlで退院となった。その後経過良好であったが、移植後3か月目に2g/日の蛋白尿を認め腎生検を施行した結果、IgA腎症の再発と診断された。扁桃腺摘出術を行い、MPZパルス療法を施行した。現在、Creは低下し、尿蛋白も減少している。, 市立札幌病院, Japanese - 腹腔鏡下腎手術において発症した横紋筋融解症の臨床的検討
高田 徳容, 高田 祐輔, 今 雅史, 石崎 淳司, 佐々木 元, 堀田 記世彦, 平野 哲夫, 原田 浩, 関 利盛, 富樫 正樹, 日本泌尿器科学会雑誌, 103, 2, 405, 405, Mar. 2012
(一社)日本泌尿器科学会, Japanese - 若年者に発症した尿管肉芽性ポリープの1例
高田 祐輔, 今 雅史, 石崎 淳司, 佐々木 元, 堀田 記世彦, 高田 徳容, 原田 浩, 関 利盛, 柳内 充, 深澤 雄一郎, 富樫 正樹, 市立札幌病院医誌, 71, 2, 233, 236, Mar. 2012
市立札幌病院, Japanese - 移植後早期に再発したIgA腎症の1例
平田 裕哉, 堀田 記世彦, 深澤 雄一郎, 佐々木 元, 高田 祐輔, 今 雅史, 石崎 淳司, 高田 徳容, 辻 隆裕, 柳内 充, 関 利盛, 富樫 正樹, 原田 浩, 市立札幌病院医誌, 71, 2, 249, 252, Mar. 2012
市立札幌病院, Japanese - Epstein-Barr virus陰性の腎移植後リンパ球増殖性疾患の1例
和田 吉生, 堀田 記世彦, 高田 祐輔, 石崎 淳司, 今 雅史, 佐々木 元, 高田 徳容, 平野 哲夫, 関 利盛, 富樫 正樹, 山本 聡, 山口 圭介, 深澤 雄一郎, 辻 隆裕, 柳内 充, 原田 浩, 市立札幌病院医誌, 71, 2, 253, 257, Mar. 2012
市立札幌病院, Japanese - 腎移植患者に対する腹腔鏡下自己腎摘の経験
関 利盛, 高田 祐輔, 今 雅史, 石崎 淳司, 佐々木 元, 高田 徳容, 富樫 正樹, 堀田 記世彦, 原田 浩, 平野 哲夫, 日本泌尿器科学会雑誌, 103, 2, 241, 241, Mar. 2012
(一社)日本泌尿器科学会, Japanese - 腎移植500症例の臨床的検討
堀田 記世彦, 佐々木 元, 高田 祐輔, 今 雅史, 石崎 淳司, 高田 徳容, 関 利盛, 富樫 正樹, 平野 哲夫, 原田 浩, 日本泌尿器科学会雑誌, 103, 2, 331, 331, Mar. 2012
(一社)日本泌尿器科学会, Japanese - タクロリムス徐放性製剤による腎移植導入免疫抑制療法の経験
三浦 正義, 原田 浩, 岩見 大基, 土橋 誠一郎, 福澤 信之, 森田 研, 堀田 記世彦, 下田 直彦, 伊藤 洋輔, 野々村 克也, 玉置 透, 今日の移植, 24, 6, 617, 620, Dec. 2011
(株)日本医学館, Japanese - 2.6cmの非機能性腫瘍と診断されていた副腎癌、Cushing症候群の1例
芦原 順也, 和田 典男, 小原 慎司, 柳澤 克之, 高田 祐輔, 今 雅史, 佐々木 元, 関 利盛, 富樫 正樹, 堀田 記世彦, 柳内 充, 深澤 雄一郎, 日本内分泌学会雑誌, 87, 3, 961, 961, Dec. 2011
(一社)日本内分泌学会, Japanese - エベロリムスによる薬剤性肺障害の一剖検例
柳内 充, 辻 隆裕, 原田 浩, 堀田 記世彦, 原田 太以佑, 臼渕 浩明, 深澤 雄一郎, 市立札幌病院医誌, 71, 1, 83, 88, Oct. 2011
市立札幌病院, Japanese - 腎移植長期生着のための新たな視点 慢性移植腎機能障害者に対するカルシニューリン阻害剤中止の効果
原田 浩, 堀田 記世彦, 佐々木 元, 石崎 淳司, 今 雅史, 高田 徳容, 高田 祐輔, 平野 哲夫, 関 利盛, 富樫 正樹, 移植, 46, 総会臨時, 142, 142, Oct. 2011
(一社)日本移植学会, Japanese - 腎移植症例における移植腎盂腎炎の検討
佐々木 元, 堀田 記世彦, 和田 吉生, 今 雅史, 石崎 淳司, 高田 徳容, 関 利盛, 富樫 正樹, 原田 浩, 移植, 46, 総会臨時, 292, 292, Oct. 2011
(一社)日本移植学会, Japanese - 腎移植患者における自己腎癌の検討
和田 吉生, 堀田 記世彦, 佐々木 元, 高田 祐輔, 石崎 淳司, 今 雅史, 高田 徳容, 平野 哲夫, 関 利盛, 富樫 正樹, 原田 浩, 移植, 46, 総会臨時, 294, 294, Oct. 2011
(一社)日本移植学会, Japanese - 腎移植後にサイトメガロウイルス網膜炎をきたした2例
佐々木 元, 堀田 記世彦, 高田 祐輔, 今 雅史, 石崎 淳司, 高田 徳容, 関 利盛, 富樫 正樹, 原田 浩, 荻野 哲男, 今泉 寛子, 市立札幌病院医誌, 71, 1, 69, 74, Oct. 2011
市立札幌病院, Japanese - 同側に手術既往のある副腎・腎に対する腹腔鏡手術の経験
関 利盛, 高田 祐輔, 今 雅史, 石崎 淳司, 佐々木 元, 高田 徳容, 富樫 正樹, 堀田 記世彦, 平野 哲夫, 原田 浩, Japanese Journal of Endourology, 24, 3, 126, 126, Oct. 2011
(一社)日本泌尿器内視鏡学会, Japanese - 腎虚血再灌流障害におけるDelta-like 4の役割
堀田 記世彦, 庄 雅之, 山戸 一郎, 八木田 秀雄, 野々村 克也, 中島 祥介, 移植, 46, 総会臨時, 262, 262, Oct. 2011
Japanese - 手術指導と安全確保 腎移植手術における手術指導と安全確保
原田 浩, 堀田 記世彦, 高田 徳容, 望月 端吾, 富樫 正樹, 関 利盛, 西日本泌尿器科, 73, 4, 170, 176, Apr. 2011
西日本泌尿器科学会, Japanese - PREVENTION OF ATROPHY OF LOWER RECTUS ABDOMINIS MUSCLE BY PRESERVATION OF INFERIOR EPIGASTRIC ARTERY AT KIDNEY TRANSPLANTATION
Daiki Iwami, Hiroshi Harada, Hajime Sasaki, Kiyohiko Hotta, Nobuyuki Fukuzawa, Ken Morita, Chihoko Miyazaki, Toshimori Seki, Masaki Togashi, Katsuya Nonomura, JOURNAL OF UROLOGY, 185, 4, E828, E829, Apr. 2011
English, Summary international conference - Prevention of Atrophy of Lower Rectus Abdominis Muscle by Preservation of Inferior Epigastric Artery at Kidney Transplantation.
D. Iwami, H. Harada, H. Sasaki, K. Hotta, N. Fukuzawa, K. Morita, K. Nonomura, AMERICAN JOURNAL OF TRANSPLANTATION, 11, 361, 361, Apr. 2011
English, Summary international conference - Significance and Therapeutic Potential of Targeting Delta-Like 4 in Renal Ischemia Reperfusion Injury
K. Hotta, M. Sho, I. Yamato, H. Yagita, K. Nonomura, Y. Nakajima, AMERICAN JOURNAL OF TRANSPLANTATION, 11, 65, 65, Apr. 2011
English, Summary international conference - Impact of Preemptive Treatment after 3 Months of Valganciclovir Prophylaxis for Kidney Transplant Donor Seropositive and Recipient Seronegative Cases
M. Miura, H. Harada, K. Hotta, S. Tsuchihashi, Y. Itoh, D. Iwami, N. Fukuzawa, N. Shimoda, K. Morita, K. Nonomura, T. Tamaki, AMERICAN JOURNAL OF TRANSPLANTATION, 11, 458, 458, Apr. 2011
English, Summary international conference - 特発性血小板減少性紫斑病を有した腎不全患者に行った血液型不適合生体腎移植の1例
内山 結理, 堀田 記世彦, 吉田 美穂, 高田 徳容, 佐藤 択矢, 望月 端吾, 村橋 範浩, 山本 聡, 関 利盛, 富樫 正樹, 平野 哲夫, 原田 浩, 市立札幌病院医誌 = Acta medica nosocomi Sapporo = The Journal of Sapporo City General Hospital, 70, 2, 89, 92, 31 Mar. 2011
症例は66歳、男性。ADPKDによる末期腎不全のため、1999年に血液透析導入となった。2009年、妻からのABC不適合生体青移植を希望され当科を受診した。移植前検査で血小板6.8万/mm 3と低値であったため血液内科にて、特発性血小板減少性紫斑病(ITP)と診断された。ヘリコバクターピロリ除菌療法を施行したが血小板数の上昇は見られなかった。また、術直前にガンマグロブリン大量投与療法を試みたが血小板は上昇せず5万/mm 3であった。そこで、術当日血小板を20単位輸血し、血液型不適合腎移植の脱感作プロトコールに従い生体腎移植を行うこととした( リッキシマブ、3回の血漿交換、バシリキシマブ、タクロリムス、ミコフェノール酸モフェチル、メチルプレドニゾロン)。移植後は即座に利尿が得られ、移植後4 日目には血清クレアチニン(Cre)1.59m g/diまで低下した。血小板は術直後7.5万/m m 3 、術後4日目には5.4万/mm 3 まで低下したが、術後6日目には11.3万/mm 3まで上昇した。その後、血小板は10万/mm 3以上を維持し退院。現在術後4ケ月経過しているが血小板11万/mm 3 と維持している。今回、治療抵抗性のITPを合併する腎不全患者に対して血液型不適合腎移植を行った。治療抵抗性のITPであったがリッキシマブを使用した免疫抑制により術後良好な腎機能とITPの改善を認め、 本症例はITP患者の腎移植に対しリツキシマブを使用した初めての報告である。, 市立札幌病院, Japanese - 原発性色素性小結節性副腎異形成に対して両側副腎摘除術を施行した一例
赤塚 正幸, 堀田 記世彦, 和田 典男, 藤澤 孝志, 佐藤 択矢, 村橋 範浩, 高田 徳容, 望月 端吾, 平野 哲夫, 原田 浩, 深澤 雄一郎, 関 利盛, 富樫 正樹, 市立札幌病院医誌 = Acta medica nosocomi Sapporo = The Journal of Sapporo City General Hospital, 70, 2, 83, 87, 31 Mar. 2011
原発性色素性小結節性副腎異形成(PPNAD)はACTH非依存性大結節性副腎過形成(AIM AH)とともに両側副腎性のクッシング症候群を呈する疾患である。AIM AH は両側副腎に大結節を認めるのに対し、PPNADはほぼ正常な構造、大きさであり診断に苦慮することが多い。しかし画像上正常であるにも関わらず、根治には副腎両側副腎摘出を要するため、術前の正確な内分泌学的診断が不可欠である。今回、非常に稀なPPNADの1例を経験したので報告する。症例は25歳女性。10歳より口唇の色素沈着を自覚。15歳時に月経不順となり近医婦人科に通院していた。22歳時検診で尿糖を指摘。以後、糖尿病と診断され、インスリン治療が開始された。しかし、血糖コントロールは不良であったため精査したところ、ACTH低値、コーチゾール高値を認めたため当院紹介となった。初診時、中心性肥満、満月様顔貌を認めた。内分泌検査では、ACTHは低値、コーチゾールは高値で日内変動は消失していた。また、8mgデキサメタゾン抑制試験で抑制を認めず、CRH負荷試験でACTHは抑制されたままであった。以上より副腎性のクッシング症候群が疑われた。CTでは右副腎に9 m mの小結節を認めるものの、両側副腎に明らかな腫瘍を認めなかった。一方、I131ーアドステロール副腎皮質シンチグラフィでは両側性の集積が認められた。以上よりPPNAD と診断し、腹月空鏡下に両側副腎摘除を施行した。摘出標本の肉眼的所見は両側とも黒色の色素沈着を呈する小結節が多発していた。また、病理組織学的所見は両側の副腎に類円型の核をもち、好酸性の豊富な胞体に褐色調のリポクロームを有する細胞が增殖していた。これらはPPNADに矛盾しない所見であった。, 市立札幌病院, Japanese - 原発性色素性小結節性副腎異形成に対して両側副腎摘除術を施行した一例
赤塚 正幸, 堀田 記世彦, 和田 典男, 藤澤 孝志, 佐藤 拓矢, 村橋 範浩, 高田 徳容, 望月 端吾, 平野 哲夫, 原田 浩, 深澤 雄一郎, 関 利盛, 富樫 正樹, 市立札幌病院医誌, 70, 2, 269, 273, Mar. 2011
市立札幌病院, Japanese - 特発性血小板減少性紫斑病を有した腎不全患者に行った血液型不適合生体腎移植の1例
内山 結理, 堀田 記世彦, 吉田 美穂, 高田 徳容, 佐藤 択矢, 望月 端吾, 村橋 範浩, 山本 聡, 関 利盛, 富樫 正樹, 平野 哲夫, 原田 浩, 市立札幌病院医誌, 70, 2, 275, 278, Mar. 2011
市立札幌病院, Japanese - Critical Role of Therapeutic Apheresis in Kidney Transplantation
Harada Hiroshi, Hotta Kiyohiko, Miura Masayoshi, 日本アフェレシス学会雑誌, 30, 2, 116, 123, 2011
The shortage of deceased organ donors results in increasing indication of kidney transplantation. The effort to understand the profound mechanism of preexisting antibodies has overcome ABO incompatibility and anti-donor specific antibodies such as the anti-HLA antibody by virtue of the development of immunosuppressants with well-designed therapeutic apheresis (TA). On the other hand, focal segmental glomerulosclerosis, which redevelops even just after transplant, often exhibits severe leakage of urinary protein. TA can decrease the amount of protein leakage and sometimes induce complete remission together with anti-inflammatory agents, including cyclosporine, mycophenolate mofetile and rituximab. Herein, we discuss the role and the practical management of TA in successfully reducing preexisting antibodies and ill-defined but possible permeability factors, which are believed to be important in the development of FSGS., 日本アフェレシス学会, Japanese - 腎移植後に発症した慢性骨髄性白血病の1例
堀田 記世彦, 岩見 大基, 坂井 俊哉, 平野 哲夫, 望月 端吾, 関 利盛, 富樫 正樹, 新藤 純理, 山本 聡, 原田 浩, 腎移植・血管外科, 22, 1, 68, 71, Dec. 2010
腎移植・血管外科研究会, Japanese - P2-219 タクロリムス新規製剤の血中動態と副作用との関連性(一般演題 ポスター発表,薬物動態・TDM・投与設計,臨床から学び臨床へと還元する医療薬学)
結城 祥充, 阿知波 一人, 黒沼 博史, 岩井 新治, 伊藤 勝美, 堀田 記世彦, 原田 浩, 平野 哲夫, 日本医療薬学会年会講演要旨集, 20, 426, 426, 25 Oct. 2010
日本医療薬学会, Japanese - 術前にFlow PRA検査にて抗ドナーHLA抗体陽性が判明した献腎移植の1例
堀田 記世彦, 平野 哲夫, 原田 浩, 佐藤 択矢, 村橋 範浩, 高田 徳容, 望月 端吾, 関 利盛, 富樫 正樹, 深澤 雄一郎, 石田 清人, 亀石 直子, 笹木 剛志, 市立札幌病院医誌, 70, 1, 67, 71, Oct. 2010
市立札幌病院, Japanese - 腎移植後早期に生じた下痢症状によりミコフェノール酸(MPA)血中濃度が著明に低下した症例
阿知波 一人, 結城 祥充, 黒沼 博史, 岩井 新治, 伊藤 勝美, 堀田 記世彦, 平野 哲夫, 原田 浩, 市立札幌病院医誌, 70, 1, 103, 108, Oct. 2010
市立札幌病院, Japanese - 腎虚血再灌流障害におけるTWEAK受容体Fn14の関与と新規治療戦略の可能性
堀田 記世彦, 庄 雅之, 山戸 一郎, 原田 浩, 八木田 秀雄, 野々村 克也, 中島 祥介, 移植, 45, 総会臨時, 196, 196, Oct. 2010
Japanese - RETROPERITONEOSCOPIC NEPHRECTOMY, EX VIVO TUMOR EXCISION AND AUTOTRANSPLANTATION FOR RENAL TUMORS
T. Seki, T. Satou, N. Murahashi, D. Iwami, K. Hotta, T. Mochizuki, N. Takada, H. Harada, M. Togashi, JOURNAL OF ENDOUROLOGY, 24, A37, A38, Sep. 2010
English, Summary international conference - 小児腎移植 現状と今後の課題 小児腎移植におけるステロイド減量・離脱
三浦 正義, 下田 直彦, 福澤 信之, 田邉 起, 堀田 記世彦, 岩見 大基, 原田 浩, 関 利盛, 佐々木 聡, 野々村 克也, 日本小児腎不全学会雑誌, 30, 68, 71, Aug. 2010
日本小児腎不全学会, Japanese - 小児腎移植におけるバルガンシクロビル予防投与の検討
下田 直彦, 三浦 正義, 福澤 信之, 田邊 起, 堀田 記世彦, 野々村 克也, 日本小児腎不全学会雑誌, 30, 286, 288, Aug. 2010
日本小児腎不全学会, Japanese - 【癌宿主応答から見た癌治療の最前線】宿主免疫回避機構を標的とした新たな癌治療の可能性
山戸 一郎, 庄 雅之, 野見 武男, 赤堀 宇広, 堀田 記世彦, 中島 祥介, 癌の臨床, 55, 11, 785, 790, Jun. 2010
(株)篠原出版新社, Japanese - CLINICAL SIGNIFICANCE OF CD45RO+MEMORY T CELL IN HUMAN RENAL CELL CARCINOMA
Kiyohiko Hotta, Masayuki Sho, Kiyohide Fujimoto, Keiji Shimada, Ichiro Yamato, Satoshi Anai, Noboru Konishi, Yoshihiko Hirao, Katsuya Nonomura, Yoshiyuki Nakajima, JOURNAL OF UROLOGY, 183, 4, E200, E201, Apr. 2010
English, Summary international conference - CLINICAL SIGNIFICANCE OF TARGETING FIBROBLAST GROWTH FACTOR-INDUCIBLE 14 IN RENAL ISCHEMIA REPERFUSION INJURY
Kiyohiko Hotta, Masayuki Sho, Ichiro Yamato, Hiroshi Harada, Takahiro Akahori, Shinji Nakamura, Hideo Yagita, Katsuya Nonomura, Yoshiyuki Nakajima, JOURNAL OF UROLOGY, 183, 4, E803, E803, Apr. 2010
English, Summary international conference - NONPEPTIDE INHIBITOR OF CATHEPSIN G ATTENUATES ACUTE KIDNEY INJURY FOLLOWING RENAL ISCHEMIA AND REPERFUSION
Naohiko Shimoda, Midori Muranaka, Kiyohiko Hotta, Katsuya Nonomura, JOURNAL OF UROLOGY, 183, 4, E803, E804, Apr. 2010
English, Summary international conference - 陰嚢内に発生した悪性線維性組織球症の1例
松本 隆児, 杉下 圭治, 村雲 雅志, 小柳 知彦, 堀田 記世彦, 中村 美智子, 豊田 裕, 足立 祐二, 泌尿器外科, 23, 4, 634, 634, Apr. 2010
医学図書出版(株), Japanese - Targeting Fibroblast Growth Factor-Inducible 14 Prevents Acute and Chronic Injury after Renal Ischemia Reperfusion
Kiyohiko Hotta, Masayuki Sho, Ichiro Yamato, Hiroshi Harada, Hideo Yagita, Katsuya Nonomura, Yoshiyuki Nakajima, AMERICAN JOURNAL OF TRANSPLANTATION, 10, 80, 80, Apr. 2010, [Peer-reviewed]
English, Summary international conference - 大腸憩室炎の泌尿器科的合併症
村雲 雅志, 小野 武紀, 今 雅史, 小柳 知彦, 杉下 圭治, 川口 愛, 大澤 崇宏, 松本 隆児, 青柳 俊紀, 中村 美智子, 豊田 裕, 堀田 記世彦, 佐澤 陽, 泌尿器外科, 23, 臨増, 481, 481, Mar. 2010
医学図書出版(株), Japanese - 腎虚血再灌流障害におけるTWEAK受容体Fn14の関与と新規治療戦略の可能性
堀田 記世彦, 庄 雅之, 山戸 一郎, 原田 浩, 八木田 秀雄, 中島 祥介, 野々村 克也, 日本泌尿器科学会雑誌, 101, 2, 220, 220, Feb. 2010
Japanese - 腎虚血再灌流障害におけるTWEAK/Fn14経路の役割
堀田 記世彦, 庄 雅之, 山戸 一郎, 原田 浩, 八木田 秀雄, 野々村 克也, 中島 祥介, 移植, 44, 総会臨時, 267, 267, Sep. 2009
Japanese - AN OPTIMAL SETTING OF PLASMAPHERESIS FOR REMOVAL OF PREEXISTING ANTIBODY BEFORE RENAL TRANSPLANTATION
Masayoshi Miura, Hiroshi Harada, Naohiko Shimoda, Nobuyuki Fukuzawa, Tatsu Tanabe, Kiyohiko Hotta, Daiki Iwami, Katsuya Nonomura, TRANSPLANT INTERNATIONAL, 22, 238, 238, Aug. 2009
English, Summary international conference - Significance and Therapeutic Potential of Targeting TWEAK/FN14 Pathway in Renal Ischemia Reperfusion Injury.
Kiyohiko Hotta, Masayuki Sho, Ichiro Yamato, Hiroshi Harada, Hideo Yagita, Katsuya Nonomura, Yoshiyuki Nakajima, AMERICAN JOURNAL OF TRANSPLANTATION, 9, 258, 258, 2009, [Peer-reviewed]
English, Summary international conference - 原発性精巣カルチノイドの1例
堀田 記世彦, 村雲 雅志, 高橋 達郎, 佐澤 陽, 石川 隆太, 田邊 起, 小柳 知彦, 泌尿器外科, 21, 9, 1333, 1336, Sep. 2008
医学図書出版(株), Japanese - Renal late ischemic preconditioning attenuates neutrophil mediated inflammation and subsequent fibrosis following renal ischemic reperfusion injury
Naohiko Shimoda, Kiyohiko Hotta, Midori Muranaka, Ken Morita, Katsuya Nonomura, AMERICAN JOURNAL OF TRANSPLANTATION, 8, 430, 430, May 2008
English, Summary international conference - Pretransplant profile of oral glucose tolerance test predicts posttransptant glucose metabolism
Masayoshi Miura, Hiroshi Harada, Tatsu Tanabe, Norikata Takada, Toshimori Seki, Masaki Togashi, Tetsuo Hirano, Naohiko Shimoda, Kiyohiko Hotta, Katsuya Nonomura, AMERICAN JOURNAL OF TRANSPLANTATION, 8, 359, 359, May 2008
English, Summary international conference - Low dose rituximab is sufficient for successful ABO-incompatible kidney transplantation
Kiyohiko Hotta, Masayoshi Miura, Hiroshi Harada, Ken Morita, Naohiko Shimoda, Tetsuo Hirano, Katsuya Nonomura, AMERICAN JOURNAL OF TRANSPLANTATION, 8, 358, 358, May 2008
English, Summary international conference - Nonpeptide inhibitor of Cathepsin G attenuates acute kidney injury following renal ischemia and reperfusion
Naohiko Shimoda, Midori Muranaka, Kiyohiko Hotta, Ken Morita, Katsuya Nonomura, AMERICAN JOURNAL OF TRANSPLANTATION, 8, 501, 501, May 2008
English, Summary international conference - 尿路異常に起因する腎不全に対する小児腎移植の成績
森田 研, 渡井 至彦, 下田 直彦, 岩見 大基, 堀田 記世彦, 野々村 克也, 日本小児腎不全学会雑誌 : 小児腎不全研究会記事, 27, 136, 139, 31 Aug. 2007
Japanese - Thickening of peritubular capillary basement membrane is a sign of subclinical chronic antibody-mediated rejection before appearance of donor specific antibody.
Masayoshi Miura, Yayoi Ogawa, Kanako C. Kubota, Kiyohiko Hotta, Kanako Morooka, Hiroshi Harada, Toshimori Seki, Masaki Togashi, Tetsuo Hirano, Katsuya Nonomura, AMERICAN JOURNAL OF TRANSPLANTATION, 7, 260, 260, May 2007
English, Summary international conference - Severely contracted bladder in renal transplant recipients after long-term dialysis is associated with higher rate of urological complications.
Kiyohiko Hotta, Masayoshi Miura, Hiroshi Harada, Naohiko Shimoda, Daiki Iwami, Ken Morita, Tetsuo Hirano, Katsuya Nonomura, AMERICAN JOURNAL OF TRANSPLANTATION, 7, 531, 531, May 2007
English, Summary international conference - Pediatric kidney transplantation for the patients with urological anomaly is safe and available compared with those with primary renal diseases.
Ken Morita, Daiki Iwami, Kiyohiko Hotta, Naohiko Shimoda, Masayoshi Miura, Yoshihiko Watarai, Katsuya Nonomura, AMERICAN JOURNAL OF TRANSPLANTATION, 7, 369, 370, May 2007
English, Summary international conference - Vesicoureteral reflux into kidney allograft has a greater negative impact on long-term graft survival.
Hiroshi Harada, Masayoshi Miura, Toshimori Seki, Kiyohiko Hotta, Kanako Morooka, Masaki Togashi, Tetsuo Hirano, AMERICAN JOURNAL OF TRANSPLANTATION, 7, 531, 531, May 2007
English, Summary international conference - Posttransplant Epstein Barr viral load monitoring in mononuclear lymphocytes using a quantitative PCR protocol: A comparison between cytomegalovirus activation status.
Hiroshi Harada, Masayoshi Miura, Toshimori Seki, Kanako Morooka, Kiyohiko Hotta, Masaki Togashi, Tetsuo Hirano, AMERICAN JOURNAL OF TRANSPLANTATION, 7, 365, 365, May 2007
English, Summary international conference - タクロリムス(TAC)併用腎移植患者におけるミコフェノール酸(MPA)の血中濃度変動要因解析
武隈 洋, 寺岡 栄美, 澤口 利香, 山崎 浩二郎, 森田 研, 下田 直彦, 堀田 記世彦, 岩見 大基, 渡井 至彦, 菅原 満, 野々村 克也, 井関 健, 移植, 42, 2, 194, 195, Apr. 2007
(一社)日本移植学会, Japanese - 既存抗体陽性腎移植の臨床的検討
三浦 正義, 下田 直彦, 原田 浩, 小川 弥生, 久保田 佳奈子, 笹木 剛志, 堀田 記世彦, 岩見 大基, 森田 研, 渡井 至彦, 関 利盛, 富樫 正樹, 平野 哲夫, 野々村 克也, 移植, 41, 6, 551, 558, 10 Dec. 2006
Japanese - 巣状糸球体硬化症による腎不全に対し、自己腎臓摘出および脾臓摘出をすることなく良好に経過しているABO不適合pre-emptive腎移植の1症例
原田 浩, 堀田 記世彦, 三浦 正義, 関 利盛, 富樫 正樹, 平野 哲夫, 腎移植・血管外科, 18, 1, 20, 24, Dec. 2006
腎移植・血管外科研究会, Japanese - ドナー腎摘出術中に損傷した下極動脈に下腹壁動脈を利用し再建しえた生体腎移植の1例
堀田 記世彦, 原田 浩, 関 利盛, 富樫 正樹, 平野 哲夫, 腎移植・血管外科, 18, 1, 46, 50, Dec. 2006
腎移植・血管外科研究会, Japanese - 【臓器移植】北海道における腎移植の現況
平野 哲夫, 原田 浩, 堀田 記世彦, 河辺 絵理, 中 牧子, 太田 和夫, 市立札幌病院医誌, 66, 1, 17, 19, Sep. 2006
市立札幌病院, Japanese - 術前診断が困難であったautosomal-dominant polycystic kidney diseaseに発生した腎細胞癌の1例
堀田 記世彦, 原田 浩, 関 利盛, 小川 弥生, 中村 美智子, 谷口 明久, 田中 敏, 武内 利直, 富樫 正樹, 平野 哲夫, 市立札幌病院医誌, 66, 1, 39, 43, Sep. 2006
市立札幌病院, Japanese - ABO血液型不一致腎移植後に溶血性貧血を発症した2症例
堀田 記世彦, 原田 浩, 関 利盛, 富樫 正樹, 平野 哲夫, 移植, 41, 4, 362, 365, Aug. 2006
(一社)日本移植学会, Japanese - タクロリムス血中濃度モニタリングのための採血法とその有用性の検討
岩見大基, 堀田記世彦, 下田直彦, 森田 研, 野々村克也, 武隈 洋, 第24回北海道腎移植談話会（札幌）, 2006 - 血清アルブミンを中心としたMPA血中濃度の変動要因解析
寺岡 栄美, 山﨑浩二郎, 菅原 満, 井関 健, 武隈 洋, 森田 研, 下田直彦, 堀田記世彦, 岩見大基, 渡井 至彦, 野々村克也, 第24回北海道腎移植談話会（札幌）, 2006
Research Themes
- Motion and image analyses of laparoscopic surgery : visualization of experts' surgical skills, and future surgical education
Grants-in-Aid for Scientific Research
01 Apr. 2024 - 31 Mar. 2027
安部 崇重, 樋口 まどか, 倉島 庸, 今 雅史, 渡辺 雅彦, 七戸 俊明, 近野 敦, 堀田 記世彦
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hokkaido University, 24K00443 - The effect of steroid for calcineurin inhibitors nephrotoxicity in kidney transplant recipients
Grants-in-Aid for Scientific Research
01 Apr. 2021 - 31 Mar. 2024
田邉 起, 村上 正晃, 篠原 信雄, 堀田 記世彦
腎移植後の長期成績の向上にはカルシニューリン阻害薬（CNI）による慢性腎毒性の克服が必要である。これまでのCNI腎毒性の概念は腎細動脈の中膜平滑筋の硝子様変化による血管毒性とされており、これにより腎の間質線維化や尿細管委縮が始まり移植腎機能低下を起こすと考えられていた。この動脈硝子化に代表される血管内皮細胞変化が慢性腎毒性のマーカーとされてきたが、尿細管や間質の上皮細胞系に注目したマーカーが必要である。
近年CNIによる炎症性サイトカインの産生の誘導が指摘されており、慢性炎症のメカニズムのひとつであるNF-κB経路とSTAT3経路の活性化が相乗的に起こる炎症増幅回路の活性化が関与している可能性がある。一方で、免疫抑制剤の一つであるステロイドには抗炎症作用があり、CNIよる炎症性サイトカイン産生誘導を抑制している可能性がある。よって本研究の目的は尿細管間質においてCNI腎毒性をステロイドが軽減しているかを検索し、さらに新規バイオマーカーの開発に取り組むことである。
まずステロイドがCNIによる腎毒性に良い影響を及ぼすかを臨床データおよび経時的な移植腎組織より解析した。当院の腎移植患者でステロイドが継続されている群と、ステロイドを早期に中止した群で、移植腎サンプルの見直しを行った。Periodic acid-Schiff stain（PAS）染色を用いて、これらの細動脈の硝子化を国際基準であるBanff分類のAlternate quantitative scoring for Hyaline Arteriolar Thickening（aahスコア）で3段階に分けて評価した。現段階でステロイド中止群においてCNI毒性が有意に高い結果がでている。この結果はステロイドが慢性腎毒性を抑制する可能性を示す重要な知見である。
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 21K09414 - Development of immunomonitoring system that predicts chronic antibody-mediated rejection in kidney transplant recipients
Grants-in-Aid for Scientific Research
01 Apr. 2021 - 31 Mar. 2024
堀田 記世彦, 村上 正晃, 田邉 起, 篠原 信雄
腎移植の短期成績は飛躍的に向上しているが、長期的にはドナー特異的抗体による慢性抗体関連型拒絶反応(CAAMR)により移植腎機能廃絶となる症例が多く、この克服が長期成績の向上に必要不可欠である。しかし、CAAMRに対する有効な治療法は未だ確立していない。当研究の目的は、CAAMRとなりうる患者を早期に発見する診断法を開発することである。当研究は３つからなり令和3年度の研究実績は以下の通りである。
1. パラフィン移植腎生検標本を用いたCAAMR関連遺伝子の検索：腎機能が正常である患者において移植後1年目、2年目に行ったプロトコール移植腎生検を用いて遺伝子解析した。結果炎症に関連する数種類の遺伝子の発現を組み合わせることにより5年目にCAAMRに至る症例と至らない症例との区別がつく可能性を見いだせた。
２．CAAMR早期診断のための尿中バイオマーカーの検索：過去に報告した尿中ORM1とSYT17の他に数種類の遺伝子候補について解析中である。
３．末梢血リンパ球反応による早期診断法の開発： 200症例につきCFSE/MLR assayを行った結果、腎機能が正常で病理学的にも問題ない患者においてはドナーに対するCD8陽性T細胞の反応は認めないが、CAAMRの患者ではドナーに対するCD8陽性T細胞の強い反応が認めた。また、CD4に関しても同様の所見を認めたが、その中でもTh1，Th17細胞の反応が強く見られた。また、抗ドナー抗体が陽性で腎生検で拒絶を認めない、前CAMR状態の患者においてもCAMRの患者と同様の反応を認めた。CFSE/MLR assayによりCAAMRが未然に診断できる可能性を見いだせた。
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 21K09389 - Development of an immunological monitoring system to predict chronic rejection in kidney transplant recipients.
Grants-in-Aid for Scientific Research
01 Apr. 2018 - 31 Mar. 2021
Hotta Kiyohiko
Chronic active antibody-mediated rejection (CAAMR) is the main cause of graft loss in the long-term. Pathological changes during CAAMR occur gradually even without clinical manifestations, followed by dysregulation of the function of the kidney transplant. Therefore, a reliable immunoresponse monitoring system to identify recipients who will develop CAAMR in the future is required.
A mixed lymphocyte reaction (MLR) assay is a method to measure T cells alloreactivity via direct pathway (DP). Recent studies indicate that DP also contribute the pathogenesis of chronic injury. However, there are no reports of MLR assay to monitor CAAMR. Therefore, we tried to develop a novel MLR monitoring system that predicts CAAMR in kidney transplant recipients. To this end, we measured the anti-donor response using our novel MLR in 150 kidney recipients whose graft status were evaluated by graft biopsy and analyzed the relationship between the anti-donor response and pathological findings of allograft.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 18K09156 - Development of an algorithm for risk of chronic antibody-mediated rejection after kidney transplant assessed by human leukocyte antigen structure-based histocompatibility
Grants-in-Aid for Scientific Research
01 Apr. 2018 - 31 Mar. 2021
Iwami Daiki
In this study, the number of mismatch eplets alone did not have a clear impact on the prognosis of transplanted kidneys. The reasons for this may be that the number of patients was not sufficient, the observation period was not long enough, and the immunosuppressive protocols have changed over the years, so the comparison under the same conditions was not possible. In addition, in the Japanese population, which has relatively low HLA diversity, there is little diversity in MM eplet numbers, and it may be difficult to show differences based on the mismatch eplets alone.
In the future, we will conduct risk stratification of CAMR based on the risk assessment of MM eplet numbers reported by various authors, use different immunosuppressive protocols accordingly, and prepare a study to launch a prospective study.
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), 18K09127
