Motion analysis for objective evaluation of psychomotor skills in Endoscopic Sinus Surgery
K Miyaji, M Suzuki, R Watanabe, T Suzuki, K Matoba, A Nakazono, Y Nakamaru, K Ebina, T Abe, D Hinder, A J Psaltis, P J Wormald, A Homma, A Konno
Rhinology Journal, Stichting Nase, 01 Dec. 2024
Scientific journal, Background: This study aims to digitalize surgical maneuvers in ESS using a motion capture system under standardized conditionsprovided by 3D printed-sinus models. Methodology: Forty-seven otolaryngologists performed ESS on 3D printed modelsmanufactured from computed tomography (CT) images of actual patients. Participants were classified to 3 groups according tothe objective structured technical skills assessment score. All surgical maneuverers performed during ESS were captured by amotion capture system. The path length, velocity, acceleration, and jerk were calculated for each surgical instrument and comparedamong the groups. Principle Component Analysis (PCA) was utilized to identify which metrics reflected surgical skill level. Inaddition, ten registrars repeated the surgical dissection. Their motion metrics were also compared between first training and therepeated training and then subjected to the PCA. Results: Several metrics such as the angular acceleration and jerk of the cuttingforceps were identified by PCA as possible indicators distinguishing the different skill levels for the ESS maneuvers. PCA analysis inthe repetitive training also found the angular metrics of the upturned-cutting forceps correlating to their skill improvement.Conclusions: Combined with the validated 3D-printed sinus models, the motion capture system provided the objective evaluationof the surgical performances of ESS.

鼻副鼻腔粘膜悪性黒色腫におけるTRIM27の検討　　　　　　　　　　　　　　　
木村 将吾, 中丸 裕爾, 鈴木 正宣, 中薗 彬, 本間 あや, 渡邉 良亮, 加納 里志, 対馬 那由多, 鈴木 崇祥, 井戸川 寛志, 本間 明宏, 渡部 昌, 近藤 豪, 畠山 鎮次
日本鼻科学会会誌, 63, 3, 336, 336, (一社)日本鼻科学会, Sep. 2024
Japanese

Neutrophil Extracellular Trap Formation and Deoxyribonuclease I Activity in Patients with Otitis Media with Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.
Shinya Morita, Yuji Nakamaru, Atsushi Fukuda, Keishi Fujiwara, Masanobu Suzuki, Kimiko Hoshino, Aya Honma, Akira Nakazono, Akihiro Homma
International archives of allergy and immunology, 185, 8, 810, 819, 2024, [International Magazine]
English, Scientific journal, INTRODUCTION: No previous studies have evaluated the levels of neutrophil extracellular trap (NET) remnants or the importance of deoxyribonuclease (DNase) I activity based on the disease activity of otitis media with antineutrophil cytoplasmic antibody-associated vasculitis (OMAAV). The aim of this study was to explore the formation of NETs in the middle ear of patients with OMAAV during the onset and remission phases of the disease, with a particular focus on the relationships between the quantifiable levels of NET remnants and DNase I activity. METHODS: OMAAV patients were eligible for inclusion. Patients with otitis media with effusion (OME) were examined as controls. The levels of cell-free deoxyribonucleic acid (DNA), citrullinated-histone H3 (cit-H3)-DNA complex, and myeloperoxidase (MPO)-DNA complex were quantified using an enzyme-linked immunosorbent assay. DNase I activity was measured using a fluorometric method. RESULTS: The quantifiable levels of cell-free DNA, cit-H3-DNA complex, and MPO-DNA complex in the middle ear lavage of patients with OMAAV at onset were significantly higher than those in patients with OMAAV at remission and in patients with OME. DNase I activity in the patients with OMAAV at onset was significantly lower than those in patients with OMAAV at remission and OME and was negatively correlated with the level of MPO-DNA complex. CONCLUSIONS: This study suggests that NET remnants and DNase I activity may be potentially useful biomarkers for the diagnosis and disease activity of OMAAV.

Clinical outcomes for olfactory neuroblastoma.
Akira Nakazono, Hiroaki Motegi, Masanobu Suzuki, Yuji Nakamaru, Shigeru Yamaguchi, Yukitomo Ishi, Satoshi Kano, Nayuta Tsushima, Aya Honma, Takayoshi Suzuki, Shogo Kimura, Seijiro Hamada, Jun Taguchi, Yasushi Shimizu, Takashi Mori, Koichi Yasuda, Hidefumi Aoyama, Ichiro Kinoshita, Miki Fujimura, Akihiro Homma
Frontiers in oncology, 14, 1329572, 1329572, 2024, [International Magazine]
English, Scientific journal, BACKGROUND: Olfactory neuroblastoma (ONB) is a rare malignant tumor arising from the olfactory neuroepithelium. The standard of care for ONB is surgical resection; however, detailed treatment protocols vary by institution. Our treatment protocol consists of endoscopic skull base surgery (ESBS) for endoscopically resectable cases and induction chemotherapy followed by craniotomy combined with ESBS for locally advanced cases, with postoperative radiotherapy performed for all cases. Chemoradiotherapy (CRT) is performed in unresectable cases. In this study, we evaluate our treatment protocol and outcomes for ONB. METHODS: A retrospective review of patients with ONB was conducted. Outcomes included survival outcomes and perioperative data. RESULTS: Fifteen patients (53.6%) underwent ESBS, 12 (42.9%) underwent craniotomy combined with ESBS, and 1 (3.6%) received CRT. The 5- and 10-year overall survival rates for all patients were 92.9% and 82.5%, respectively, with a median follow-up period of 81 months. The 5- and 10-year disease-free survival rates were 77.3% and 70.3%, respectively, and the 5- and 10-year local control rates were 88.2% and 80.2%, respectively. Patients undergoing ESBS demonstrated a significantly shorter operating time, period from operation to ambulation, hospitalization period, and less blood loss than those undergoing craniotomy combined with ESBS. CONCLUSION: Our treatment protocol was found to afford favorable outcomes. Patients who underwent endoscopic resection showed lower complication rates and better perioperative data than those who underwent craniotomy combined with ESBS. With appropriate case selection, ESBS is considered a useful approach for ONB.

TRIM27の鼻副鼻腔粘膜悪性黒色腫におけるバイオマーカーとしての検討
木村 将吾, 中丸 裕爾, 鈴木 正宣, 本間 あや, 中薗 彬, 加納 里志, 対馬 那由多, 鈴木 崇祥, 浜田 誠二郎, 本間 明宏
日本耳鼻咽喉科頭頸部外科学会会報, 126, 4, 562, 562, (一社)日本耳鼻咽喉科頭頸部外科学会, Apr. 2023
Japanese

TRIM27 expression is associated with poor prognosis in sinonasal mucosal melanoma.
S Kimura, M Suzuki, Y Nakamaru, S Kano, M Watanabe, A Honma, A Nakazono, N Tsushima, S Hatakeyama, A Homma
Rhinology, 09 Mar. 2023, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: Tripartite motif-containing 27 (TRIM27) has been implicated in the progression of various cancers. However, the role of TRIM27 in sinonasal mucosal melanoma (SNMM) remains poorly understood. MATERIALS & METHODS: We retrospectively examined 28 patients with SNMM treated with between 2003 and 2021. We undertook immunohistochemical analysis of TRIM27, Ki-67, and p-Akt1 expression in SNMM tissues. We also investigated the relationship between TRIM27 expression and clinical characteristics, prognosis, Ki-67 as a tumor growth potential marker, and p-Akt1 as one of the prognostic factors in mucosal melanoma. RESULTS: TRIM27 expression was significantly higher in T4 disease than in T3 disease and was higher in stage IV than in stage III. Patients with high-TRIM27 SNMM had a significantly poorer prognosis in terms of overall survival (OS) and disease-free survival.There was also a significantly higher rate of distant metastasis. Univariate analysis for OS revealed that TRIM27 and T classification were significant poor prognostic factors. In addition, the Ki-67 positive score and the p-Akt1 total staining score were significantly higher in the high-TRIM27 group than in the low-TRIM27 group. CONCLUSIONS: High TRIM27 expression in SNMM was associated with advanced T classification, poor prognosis and distant metastasis. We suggest that TRIM27 has potential as a novel biomarker for prognosis in SNMM.

Nasal irrigation improving nasal obstruction and QoL of patients: two cases of HHT after nasal dermoplasty
Hideaki Takeda, Masanobu Suzuki, Yuji Nakamaru, Shogo Kimura, Akira Nakazono, Aya Honma, Akihiro Homma
JOURNAL OF JAPAN SOCIETY FOR HEAD AND NECK SURGERY, 32, 3, 299, 303, Japan Society for Head and Neck Surgery, 2023
Scientific journal

Mental workload during endoscopic sinus surgery is associated with surgeons' skill levels.
Masanobu Suzuki, Kou Miyaji, Kotaro Matoba, Takashige Abe, Yuji Nakamaru, Ryosuke Watanabe, Takayoshi Suzuki, Akira Nakazono, Atsushi Konno, Dominik Hinder, A J Psaltis, P J Wormald, Akihiro Homma
Frontiers in medicine, 10, 1090743, 1090743, 2023, [International Magazine]
English, Scientific journal, INTRODUCTION: Surgeons' mental workload during endoscopic sinus surgery (ESS) has not been fully evaluated. The assessment was challenging due to the great diversity of each patient's anatomy and the consequence variety of surgical difficulties. In this study, we examined the mental workload of surgeons with various surgical skill levels during ESS under the standardized condition provided by novel-designed 3D sinus models. MATERIALS AND METHODS: Forty-seven participants performed a high-fidelity ESS simulation with 3D-printed sinus models. Surgeons' mental workload was assessed with the national aeronautics and space administration-task load index (NASA-TLX). Associations between the total and subscales score of NASA-TLX and surgical skill index, including the board certification status, the number of experienced ESS cases, and the objective structured assessment of technical skills (OSATS), were analyzed. In addition, 10 registrars repeated the simulation surgery, and their NASA-TLX score was compared before and after the repetitive training. RESULTS: The total NASA-TLX score was significantly associated with OSATS score (p = 0.0001). Primary component analysis classified the surgeons' mental burden into three different categories: (1) the skill-level-dependent factors (temporal demand, effort, and performance), (2) the skill-level-independent factors (mental and physical demand), and (3) frustration. After the repetitive training, the skill-level-dependent factors were alleviated (temporal demand; z = -2.3664, p = 0.0091, effort; z = -2.1704, p = 0.0346, and performance; z = -2.5992, p = 0.0017), the independent factors were increased (mental demand; z = -2.5992, p = 0.0023 and physical demand; z = -2.2509, p = 0.0213), and frustration did not change (p = 0.3625). CONCLUSION: Some of the mental workload during ESS is associated with surgical skill level and alleviated with repetitive training. However, other aspects remain a burden or could worsen even when surgeons have gained surgical experience. Routine assessment of registrars' mental burdens would be necessary during surgical training to sustain their mental health.

鼻副鼻腔扁平上皮癌に対する内視鏡下鼻副鼻腔手術　　　　　　　　　　　　　　　
中丸 裕爾, 鈴木 正宣, 本間 あや, 中薗 彬, 木村 将吾, 渡邉 良亮, 本間 明宏
日本鼻科学会会誌, 61, 3, 474, 474, Oct. 2022

TRIM27の副鼻腔粘膜悪性黒色腫バイオマーカーとしての検討　　　　　　　　　　　　　　　
木村 将吾, 中丸 裕爾, 鈴木 正宣, 本間 あや, 中薗 彬, 渡邉 良亮, 本間 明宏
日本鼻科学会会誌, 61, 3, 475, 475, Oct. 2022

副鼻腔3Dモデルを用いたESSトレーニングの妥当性・有効性の検討　　　　　　　　　　　　　　　
鈴木 正宣, 中丸 裕爾, 渡邉 良亮, 中薗 彬, 木村 将吾, 本間 あや, Wormald Peter-John, Psaltis Alkis-James, 本間 明宏
日本鼻科学会会誌, 61, 3, 558, 558, Oct. 2022

Repetitive simulation training with novel 3D-printed sinus models for functional endoscopic sinus surgeries.
Masanobu Suzuki, Kou Miyaji, Ryosuke Watanabe, Takayoshi Suzuki, Kotaro Matoba, Akira Nakazono, Yuji Nakamaru, Atsushi Konno, Alkis James Psaltis, Takashige Abe, Akihiro Homma, Peter-John Wormald
Laryngoscope investigative otolaryngology, 7, 4, 943, 954, Aug. 2022, [International Magazine]
English, Scientific journal, Background: The purpose of this study was to find a utility of a newly developed 3D-printed sinus model and to evaluate the educational benefit of simulation training with the models for functional endoscopic sinus surgery (FESS). Material and methods: Forty-seven otolaryngologists were categorized as experts (board-certified physicians with ≥200 experiences of FESS, n = 9), intermediates (board-certified physicians with <200 experiences of FESS, n = 19), and novices (registrars, n = 19). They performed FESS simulation training on 3D-printed models manufactured from DICOM images of computed tomography (CT) scan of real patients. Their surgical performance was assessed with the objective structured assessment of technical skills (OSATS) score and dissection quality evaluated radiologically with a postdissection CT scan. First we evaluated the face, content, and constructive values. Second we evaluated the educational benefit of the training. Ten novices underwent training (training group) and their outcomes were compared to the remaining novices without training (control group). The training group performed cadaveric FESS surgeries before and after the repetitive training. Results: The feedback from experts revealed high face and content value of the 3D-printed models. Experts, intermediates, and novices demonstrated statistical differences in their OSATS scores (74.7 ± 3.6, 58.3 ± 10.1, and 43.1 ± 11.1, respectively, p < .001), and dissection quality (81.1 ± 13.1, 93.7 ± 15.1, and 126.4 ± 25.2, respectively, p < .001). The training group improved their OSATS score (41.1 ± 8.0 to 61.1 ± 6.9, p < .001) and dissection quality (122.1 ± 22.2 to 90.9 ± 10.3, p = .013), while the control group not. After training, 80% of novices with no prior FESS experiences completed surgeries on cadaver sinuses. Conclusion: Repeated training using the models revealed an initial learning curve in novices, which was confirmed in cadaveric mock FESS surgeries. Level of evidence: N/A.

内視鏡下頭蓋底手術を考慮した嗅神経芽細胞腫に対する新規病期分類の検討
中薗 彬, 中丸 裕爾, 鈴木 正宣, 本間 あや, 木村 将吾, 本間 明宏
日本耳鼻咽喉科頭頸部外科学会会報, 125, 4, 702, 702, (一社)日本耳鼻咽喉科頭頸部外科学会, Apr. 2022
Japanese

術前呼吸機能検査による鼻茸を伴う副鼻腔炎の予後推測　　　　　　　　　　　　　　　
中丸 裕爾, 鈴木 正宣, 本間 あや, 中薗 彬, 木村 将吾, 本間 明宏
日本耳鼻咽喉科免疫アレルギー感染症学会抄録集, 2回, 77, 77, 日本耳鼻咽喉科免疫アレルギー感染症学会, Mar. 2022
Japanese

鼻粘膜上皮細胞での細菌・ウィルス結合受容体発現に対する自然免疫シグナルの影響　　　　　　　　　　　　　　　
中薗 彬, 木村 将吾, 本間 あや, 鈴木 正宣, 中丸 裕爾, 本間 明宏
日本耳鼻咽喉科免疫アレルギー感染症学会抄録集, 2回, 168, 168, 日本耳鼻咽喉科免疫アレルギー感染症学会, Mar. 2022
Japanese

鼻粘膜上皮におけるMetallothionein-3発現解析　　　　　　　　　　　　　　　
鈴木 正宣, 中丸 裕爾, 中薗 彬, 本間 あや, 木村 将吾, 本間 明宏
日本耳鼻咽喉科免疫アレルギー感染症学会抄録集, 2回, 185, 185, 日本耳鼻咽喉科免疫アレルギー感染症学会, Mar. 2022
Japanese

前頭開頭術後に生じた前頭蓋底粘液嚢胞の2例
山田 真司, 鈴木 正宣, 中丸 裕爾, 本間 あや, 中薗 彬, 木村 将吾, 安川 真一郎, 蠣崎 文彦, 本間 明宏
耳鼻咽喉科・頭頸部外科, 94, 2, 183, 187, Feb. 2022

鼻腔組織からのRNA抽出およびqPCR解析(ビデオ講習)　　　　　　　　　　　　　　　
鈴木 正宣, 中薗 彬
日本鼻科学会会誌, 60, 3, 233, 233, (一社)日本鼻科学会, Sep. 2021
Japanese

鼻中隔前彎の客観的評価と適切な鼻中隔矯正術の術式選択　　　　　　　　　　　　　　　
木村 将吾, 中丸 裕爾, 鈴木 正宣, 本間 あや, 中薗 彬, 本間 明宏
日本鼻科学会会誌, 60, 3, 312, 312, (一社)日本鼻科学会, Sep. 2021
Japanese

鼻粘膜上皮細胞におけるTLR3依存性自然免疫シグナル　　　　　　　　　　　　　　　
鈴木 正宣, 中丸 裕爾, 中薗 彬, 本間 あや, 木村 将吾, Sarah Vreugde, Wormald PJ, 本間 明宏
日本鼻科学会会誌, 60, 3, 352, 352, (一社)日本鼻科学会, Sep. 2021
Japanese

Objective evaluation of caudal deviation of the nasal septum and selection of the appropriate septoplasty technique.
Shogo Kimura, Masanobu Suzuki, Aya Honma, Akira Nakazono, Masayuki Osawa, Yuji Nakamaru, Akihiro Homma
Auris, nasus, larynx, 49, 1, 67, 76, 06 May 2021, [International Magazine]
English, Scientific journal, OBJECTIVE: Several methods have been reported to correct caudal deviation of the nasal septum, including open septorhinoplasty (OSR) and septoplasty with Killian incision (KI). In general, OSR is applied instead of KI for caudal deviation. However, there is little objective evidence own on the effects of OSR and KI for caudal deviation. In this study, we compared surgical outcomes between OSR and KI by quantifying nasal septum deviation using two simple and objective parameters on routine paranasal sinus CT scans. METHODS: We retrospectively analyzed 18 patients who underwent OSR and 11 patients who underwent septoplasty with KI between April 2006 and October 2019. Caudal deviation was defined on the basis of the "Anterior-posterior Position of the most deviated point of the nasal septum (AP)," which was measured on computerized tomography. The deformation rate (DR) of the nasal septum was also calculated. Nasal airway resistance and visual analogue scale (VAS) score for nasal obstruction were examined. RESULTS: The AP was significantly correlated with the VAS score (r=-0.58, p=0.017). The DR in patients with caudal septal deviation was significantly decreased by OSR (0.14±0.06 to 0.03±0.03, p=0.004), but not by KI (0.09±0.08 to 0.04±0.03, p=0.25). OSR also improved nasal airway resistance (1.10±0.44 to 0.42±0.15, p=0.02), and the VAS score (79.11±14.74 to 5.78±7.89, p=0.004). CONCLUSION: Nasal obstruction is more severe in patients with the caudal deviation. OSR corrects caudal deviation of the nasal septum more effectively than does KI. The AP could be useful for the evaluation of the deviation of the nasal septum and help in selecting the appropriate septoplastic technique.

鼻腔粘膜上皮細胞における新型コロナウィルス細胞侵入因子の発現制御機構　　　　　　　　　　　　　　　
中薗 彬, 鈴木 正宣, 木村 将吾, 本間 あや, 中丸 裕爾, Ramezanpour Mahnaz, Vreugde Sarah, Wormald P.J., 本間 明宏
日本耳鼻咽喉科免疫アレルギー感染症学会抄録集, 1回, 127, 127, 日本耳鼻咽喉科免疫アレルギー感染症学会, May 2021
Japanese

Fluticasone Propionate Suppresses Poly(I:C)-Induced ACE2 in Primary Human Nasal Epithelial Cells
Akira Nakazono, Yuji Nakamaru, Mahnaz Ramezanpour, Takeshi Kondo, Masashi Watanabe, Shigetsugu Hatakeyama, Shogo Kimura, Aya Honma, P. J. Wormald, Sarah Vreugde, Masanobu Suzuki, Akihiro Homma
Frontiers in Cellular and Infection Microbiology, 11, 655666, 655666, Frontiers Media SA, 26 Apr. 2021, [International Magazine]
English, Scientific journal, From the first detection in 2019, SARS-CoV-2 infections have spread rapidly worldwide and have been proven to cause an urgent and important health problem. SARS-CoV-2 cell entry depends on two proteins present on the surface of host cells, angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2). The nasal cavity is thought to be one of the initial sites of infection and a possible reservoir for dissemination within and between individuals. However, it is not known how the expression of these genes is regulated in the nasal mucosa.

In this study, we examined whether the expression of ACE2 and TMPRSS2 is affected by innate immune signals in the nasal mucosa. We also investigated how fluticasone propionate (FP), a corticosteroid used as an intranasal steroid spray, affects the gene expression.

Primary human nasal epithelial cells (HNECs) were collected from the nasal mucosa and incubated with Toll-like receptor (TLR) agonists and/or fluticasone propionate (FP), followed by quantitative PCR, immunofluorescence, and immunoblot analyses.

Among the TLR agonists, the TLR3 agonist Poly(I:C) significantly increased ACE2 and TMPRSS2 mRNA expression in HNECs (ACE2 36.212±11.600-fold change, p&lt;0.0001; TMPRSS2 5.598±2.434-fold change, p=0.031). The ACE2 protein level was also increased with Poly(I:C) stimulation (2.884±0.505-fold change, p=0.003). The Poly(I:C)-induced ACE2 expression was suppressed by co-incubation with FP (0.405±0.312-fold change, p=0.044).

The activation of innate immune signals via TLR3 promotes the expression of genes related to SARS-CoV2 cell entry in the nasal mucosa, although this expression is suppressed in the presence of FP. Further studies are required to evaluate whether FP suppresses SARS-CoV-2 viral cell entry.

Role of intracellular zinc in molecular and cellular function in allergic inflammatory diseases.
Masanobu Suzuki, Takayoshi Suzuki, Masashi Watanabe, Shigetsugu Hatakeyama, Shogo Kimura, Akira Nakazono, Aya Honma, Yuji Nakamaru, Sarah Vreugde, Akihiro Homma
Allergology international : official journal of the Japanese Society of Allergology, 70, 2, 190, 200, Apr. 2021, [International Magazine]
English, Scientific journal, Zinc is an essential micronutrient in human body and a vital cofactor for the function of numerous proteins encoded by the human genome. Zinc has a critical role in maintaining many biochemical and physiological processes at the molecular, cellular, and multiple organ and systemic levels. The alteration of zinc homeostasis causes dysfunction of many organs and systems. In the immune system, zinc regulates the differentiation, proliferation and function of inflammatory cells, including T cells, eosinophils, and B cells, by modifying several signaling pathways such as NFκB signaling pathways and TCR signals. An adequate zinc level is essential for proper immune responses and decreased zinc levels were reported in many allergic inflammatory diseases, including atopic dermatitis, bronchial asthma, and chronic rhinosinusitis. Decreased zinc levels often enhance inflammatory activation. On the other hand, the inflammatory conditions alter the intracellular homeostasis of zinc, often decreasing zinc levels. These findings implied that there could be a vicious cycle between zinc deficiency and inflammatory conditions. In this review, we present recent evidence on the involvement of zinc in atopic dermatitis, bronchial asthma, and chronic rhinosinusitis, with insights into the involvement of zinc in the underlying molecular and cellular mechanisms related to these allergic inflammatory diseases.

The role of endoscopic resection for selected patients with sinonasal squamous cell carcinoma.
Yuji Nakamaru, Masanobu Suzuki, Satoshi Kano, Takatsugu Mizumachi, Nayuta Tsushima, Takayoshi Suzuki, Aya Honma, Akira Nakazono, Shogo Kimura, Rikiya Onimaru, Koichi Yasuda, Hiroki Shirato, Akihiro Homma
Auris, nasus, larynx, 48, 1, 131, 137, Feb. 2021, [International Magazine]
English, Scientific journal, OBJECTIVE: Despite of rapid advances in endoscopic surgery, the gold standard for sinonasal squamous cell carcinoma (SNSCC) surgery has remained the open approach with en-block resection due to the aggressive nature of SNSCC, including frequent recurrence and high mortality rate. For that reason, few studies have focused on SNSCC treated by endoscopic surgery alone. The objective of this study was to evaluate the usefulness of endoscopic surgery for patients with SNSCC. METHODS: A retrospective analysis was performed for 15 consecutive SNSCC patients who underwent endoscopic surgery without an open approach. We carefully selected patients whose tumor attachment sites could be fully visualized and completely resected through an endonasal approach. RESULTS: Of the fifteen patients, 4 patients (27%) were diagnosed with T1, 7 (47%) with T2, 4 (27%) with T3, and no patients with T4a or T4b disease. Four of the 15 (27%) patients showed positive surgical margins. The 5-yr overall survival, disease-specific survival, and local control rate was 72.4%, 79.6%, and 92.9%, respectively. The 5-yr disease-specific survival for T1, T2, and T3 disease was 100% and 75% and 75%, respectively. Patients with negative surgical margins had a better disease-specific survival rate than did those with positive surgical margins (p = 0.0253). CONCLUSION: Endoscopic surgery for patients with SNSCC appears to afford an effective method in selected cases. The achievement of negative surgical margins with a good view of the tumor attachment site was considered to be critical to the management of SNSCC.

TLR Signals in Epithelial Cells in the Nasal Cavity and Paranasal Sinuses.
Masanobu Suzuki, Clare Cooksley, Takayoshi Suzuki, Mahnaz Ramezanpour, Akira Nakazono, Yuji Nakamaru, Akihiro Homma, Sarah Vreugde
Frontiers in allergy, 2, 780425, 780425, 2021, [International Magazine]
English, Scientific journal, The respiratory tract is constantly at risk of invasion by microorganisms such as bacteria, viruses, and fungi. In particular, the mucosal epithelium of the nasal cavity and paranasal sinuses is at the very forefront of the battles between the host and the invading pathogens. Recent studies have revealed that the epithelium not only constitutes a physical barrier but also takes an essential role in the activation of the immune system. One of the mechanisms equipped in the epithelium to fight against microorganisms is the Toll-like receptor (TLR) response. TLRs recognize common structural components of microorganisms and activate the innate immune system, resulting in the production of a plethora of cytokines and chemokines in the response against microbes. As the epithelia-derived cytokines are deeply involved in the pathogenesis of inflammatory conditions in the nasal cavity and paranasal sinuses, such as chronic rhinosinusitis (CRS) and allergic rhinitis (AR), the molecules involved in the TLR response may be utilized as therapeutic targets for these diseases. There are several differences in the TLR response between nasal and bronchial epithelial cells, and knowledge of the TLR signals in the upper airway is sparse compared to that in the lower airway. In this review, we provide recent evidence on TLR signaling in the upper airway, focusing on the expression, regulation, and responsiveness of TLRs in human nasal epithelial cells (HNECs). We also discuss how TLRs in the epithelium are involved in the pathogenesis of, and possible therapeutic targeting, for CRS and AR.

Comparison of clinical characteristics of the nasal manifestations of eosinophilic granulomatosis with polyangiitis (EGPA) and eosinophilic chronic rhinosinusitis (ECRS).
Masanobu Suzuki, Akira Nakazono, Shinya Morita, Atsushi Fukuda, Aya Honma, Takayoshi Suzuki, Shogo Kimura, Yuji Nakamaru, Akihiro Homma
Allergology international : official journal of the Japanese Society of Allergology, 70, 1, 143, 144, Jan. 2021, [International Magazine]
English

低亜鉛が鼻粘膜のサイトカイン産生と炎症細胞浸潤に及ぼす影響　　　　　　　　　　　　　　　
鈴木 正宣, 中丸 裕爾, 本間 あや, 中薗 彬, 木村 将吾, Ramenzanpoir Mahnaz, Vreugde Sarah, Wormald Peter-John, 本間 明宏
耳鼻咽喉科免疫アレルギー, 38, 4, 194, 195, Dec. 2020

狭鼻を伴うアレルギー性鼻炎、慢性副鼻腔炎に下甲介shoulder osteotomyを施行した1例　　　　　　　　　　　　　　　
田中 大地, 中丸 裕爾, 鈴木 正宣, 本間 あや, 中薗 彬, 木村 将吾, 本間 明宏
耳鼻咽喉科免疫アレルギー, 38, 4, 204, 205, Dec. 2020

Preoperative Pulmonary Function Testing to Predict Recurrence of Chronic Rhinosinusitis With Nasal Polyps
Yuji Nakamaru, Masanobu Suzuki, Aya Honma, Akira Nakazono, Shogo Kimura, Keishi Fujiwara, Shinya Morita, Satoshi Konno, Akihiro Homma
ALLERGY & RHINOLOGY, 11, 2152656720946994, 2152656720946994, Jul. 2020, [International Magazine]
English, Scientific journal

頭頸部粘膜悪性黒色腫に対する術後陽子線治療30GyE/5回の初期経験　　　　　　　　　　　　　　　
湊川 英樹, 安田 耕一, 出倉 康裕, 鈴木 正宣, 中丸 裕爾, 中薗 彬, 鈴木 崇祥, 対馬 那由多, 加納 里志, 鬼丸 力也, 清水 伸一, 本間 明宏, 青山 英史
頭頸部癌, 46, 2, 188, 188, (一社)日本頭頸部癌学会, Jul. 2020
Japanese

Hybrid法による気管切開術 肥満を合併した深頸部膿瘍2症例での経験　　　　　　　　　　　　　　　
中薗 彬, 古田 康, 津布久 崇, 松村 道哉
頭頸部外科, 29, 2, 235, 239, Oct. 2019

当科における局所進行外耳道扁平上皮癌の治療成績の検討
加納 里志, 森田 真也, 中丸 裕爾, 水町 貴諭, 対馬 那由多, 鈴木 崇祥, 中薗 彬, 福田 篤, 安田 耕一, 鬼丸 力也, 白土 博樹, 本間 明宏
頭頸部癌, 45, 3, 300, 304, (一社)日本頭頸部癌学会, Oct. 2019
Japanese

当院における外鼻形成術および鼻中隔矯正術施行例の検討　　　　　　　　　　　　　　　
木村 将吾, 中丸 裕爾, 鈴木 正宣, 本間 あや, 中薗 彬, 本間 明宏
日本鼻科学会会誌, 58, 3, 632, 632, (一社)日本鼻科学会, Sep. 2019
Japanese

北海道大学病院における口腔癌(舌癌を除く)の臨床的検討　　　　　　　　　　　　　　　
中薗 彬, 鈴木 崇祥, 安川 真一郎, 水町 貴諭, 加納 里志, 本間 明宏, 福田 諭
耳鼻咽喉科展望, 62, 補冊1, 36, 37, Jun. 2019

Treatment outcomes of local advanced external auditory canal squamous cell carcinomas
Satoshi Kano, Shinya Morita, Yuji Nakamaru, Takatsugu Mizumachi, Nayuta Tsushima, Takayoshi Suzuki, Akira Nakazono, Atsushi Fukuda, Koichi Yasuda, Rikiya Onimaru, Hiroki Shirato, Akihiro Homma
Japanese Journal of Head and Neck Cancer, 45, 3, 300, 304, 2019, [Peer-reviewed]
Scientific journal

喉頭鏡固定システムの試作品　　　　　　　　　　　　　　　
溝口 兼司, 水町 貴諭, 加納 里志, 中薗 彬, 本間 明宏
耳鼻咽喉科展望, 61, 6, 351, 352, Dec. 2018

喉頭癌cT3の喉頭温存治療(CRT vs RADPLAT) 喉頭癌に対する超選択的動注と放射線同時併用療法
本間 明宏, 加納 里志, 水町 貴諭, 中薗 彬, 鈴木 崇祥, 坂下 智博, 福田 諭, 鬼丸 力也, 安田 耕一, 湊川 英樹, 出倉 康裕, 土屋 和彦, 白土 博樹
日本気管食道科学会会報, 69, 5, 319, 320, (NPO)日本気管食道科学会, Oct. 2018
Japanese

当院における嗅神経芽細胞腫の治療方針と成績　　　　　　　　　　　　　　　
中薗 彬, 中丸 裕爾, 鈴木 正宣, 水町 貴諭, 高木 大, 本間 明宏
日本鼻科学会会誌, 57, 3, 429, 429, (一社)日本鼻科学会, Sep. 2018
Japanese

篩骨動脈を茎とする鼻中隔粘膜弁を用いた鼻中隔穿孔閉鎖術の1例　　　　　　　　　　　　　　　
勝俣 量平, 鈴木 正宣, 中薗 彬, 中丸 裕爾, 本間 明宏
日本鼻科学会会誌, 57, 3, 504, 504, (一社)日本鼻科学会, Sep. 2018
Japanese

Genetic mutation analysis of the malignant transformation of sinonasal inverted papilloma by targeted amplicon sequencing
Shinichiro Yasukawa, Satoshi Kano, Hiromitsu Hatakeyama, Yuji Nakamaru, Dai Takagi, Takatsugu Mizumachi, Masanobu Suzuki, Takayoshi Suzuki, Akira Nakazono, Shinya Tanaka, Hiroshi Nishihara, Akihiro Homma
International Journal of Clinical Oncology, 23, 5, 1, 9, Springer Tokyo, 19 May 2018, [Peer-reviewed], [Domestic magazines]
English, Scientific journal

当科における局所進行外耳道扁平上皮癌の治療成績の検討　　　　　　　　　　　　　　　
加納 里志, 森田 真也, 中丸 裕爾, 水町 貴諭, 中薗 彬, 福田 篤, 安田 耕一, 鬼丸 力也, 白土 博樹, 本間 明宏
頭頸部癌, 44, 2, 181, 181, (一社)日本頭頸部癌学会, May 2018
Japanese

唾液腺導管癌における免疫染色およびRT-PCR法を用いた分子生物学的プロファイルの検討　　　　　　　　　　　　　　　
鈴木 崇祥, 加納 里志, 畑中 佳奈子, 鈴木 正宣, 安川 真一郎, 中薗 彬, 水町 貴諭, 畑中 豊, 松野 吉宏, 本間 明宏
頭頸部癌, 44, 2, 179, 179, (一社)日本頭頸部癌学会, May 2018
Japanese

穿刺吸引細胞診後の甲状腺腫脹　　　　　　　　　　　　　　　
土地 宏朋, 中薗 彬, 津布久 崇, 松村 道哉, 古田 康
北海道医学雑誌, 93, 1, 71, 71, 北海道医学会, May 2018
Japanese

唾液腺導管癌における免疫染色およびRT-PCR法を用いた分子生物学的プロファイルの検討　　　　　　　　　　　　　　　
鈴木 崇祥, 加納 里志, 畑中 佳奈子, 鈴木 正宣, 安川 真一郎, 中薗 彬, 水町 貴諭, 畑中 豊, 松野 吉宏, 本間 明宏
頭頸部癌, 44, 2, 179, 179, (一社)日本頭頸部癌学会, May 2018
Japanese

当科における局所進行外耳道扁平上皮癌の治療成績の検討　　　　　　　　　　　　　　　
加納 里志, 森田 真也, 中丸 裕爾, 水町 貴諭, 中薗 彬, 福田 篤, 安田 耕一, 鬼丸 力也, 白土 博樹, 本間 明宏
頭頸部癌, 44, 2, 181, 181, (一社)日本頭頸部癌学会, May 2018
Japanese

Validation of the 8th edition of the AJCC/UICC TNM staging system for tongue squamous cell carcinoma
Satoshi Kano, Tomohiro Sakashita, Nayuta Tsushima, Takatsugu Mizumachi, Akira Nakazono, Takayoshi Suzuki, Shinichiro Yasukawa, Akihiro Homma
International Journal of Clinical Oncology, 23, 5, 1, 7, Springer Tokyo, 19 Apr. 2018, [Peer-reviewed], [Domestic magazines]
English, Scientific journal

舌扁平上皮癌における新しいTNM分類の有用性の検討
加納 里志, 水町 貴諭, 対馬 那由多, 鈴木 崇祥, 中薗 彬, 安川 真一郎, 本間 明宏
日本耳鼻咽喉科学会会報, 121, 4, 578, 578, (一社)日本耳鼻咽喉科学会, Apr. 2018
Japanese

当院における嗅神経芽細胞腫の治療方針と成績
中丸 裕爾, 高木 大, 鈴木 正宣, 加納 里志, 水町 貴諭, 中薗 彬, 本間 明宏
日本耳鼻咽喉科学会会報, 121, 4, 567, 567, (一社)日本耳鼻咽喉科学会, Apr. 2018
Japanese

唾液腺導管癌における遺伝子発現解析および発生様式間の比較検討
鈴木 崇祥, 加納 里志, 鈴木 正宣, 安川 真一郎, 中薗 彬, 水町 貴諭, 本間 明宏
日本耳鼻咽喉科学会会報, 121, 4, 541, 541, (一社)日本耳鼻咽喉科学会, Apr. 2018
Japanese

鼻副鼻腔内反性乳頭腫の悪性転化に関与する遺伝子変異の解析　　　　　　　　　　　　　　　
安川 真一郎, 加納 里志, 畠山 博充, 中丸 裕爾, 高木 大, 水町 貴諭, 鈴木 正宣, 鈴木 崇祥, 中薗 彬, 本間 明宏
日本耳鼻咽喉科学会会報, 121, 4, 539, 539, (一社)日本耳鼻咽喉科学会, Apr. 2018
Japanese

鼻副鼻腔内反性乳頭腫の悪性転化に関与する遺伝子変異の解析
安川 真一郎, 加納 里志, 畠山 博充, 中丸 裕爾, 高木 大, 水町 貴諭, 鈴木 正宣, 鈴木 崇祥, 中薗 彬, 本間 明宏
日本耳鼻咽喉科学会会報, 121, 4, 539, 539, (一社)日本耳鼻咽喉科学会, Apr. 2018
Japanese

唾液腺導管癌における遺伝子発現解析および発生様式間の比較検討
鈴木 崇祥, 加納 里志, 鈴木 正宣, 安川 真一郎, 中薗 彬, 水町 貴諭, 本間 明宏
日本耳鼻咽喉科学会会報, 121, 4, 541, 541, (一社)日本耳鼻咽喉科学会, Apr. 2018
Japanese

当院における嗅神経芽細胞腫の治療方針と成績
中丸 裕爾, 高木 大, 鈴木 正宣, 加納 里志, 水町 貴諭, 中薗 彬, 本間 明宏
日本耳鼻咽喉科学会会報, 121, 4, 567, 567, (一社)日本耳鼻咽喉科学会, Apr. 2018
Japanese

舌扁平上皮癌における新しいTNM分類の有用性の検討　　　　　　　　　　　　　　　
加納 里志, 中薗 彬, 水町 貴諭, 本間 明宏
日本癌治療学会学術集会抄録集, 55回, P157, 4, (一社)日本癌治療学会, Oct. 2017
Japanese

舌扁平上皮癌における新しいTNM分類の有用性の検討　　　　　　　　　　　　　　　
加納 里志, 中薗 彬, 水町 貴諭, 本間 明宏
日本癌治療学会学術集会抄録集, 55回, P157, 4, (一社)日本癌治療学会, Oct. 2017
Japanese

Parathyroid crisis due to parathyroid tumor: Case report　　　　　　　　　　　　　　　
Hirolomo Dochi, Akira Nakazono, Takashi Tsubuku, Michiya Matsumura, Yasushi Furuta
Otolaryngology - Head and Neck Surgery (Japan), 89, 9, 741, 747, Igaku-Shoin Ltd, 01 Aug. 2017
Japanese, Scientific journal

高Ca血症クリーゼを呈した副甲状腺腫瘍の2症例　　　　　　　　　　　　　　　
土地 宏朋, 中薗 彬, 津布久 崇, 松村 道哉, 古田 康
耳鼻咽喉科・頭頸部外科, 89, 9, 741, 747, (株)医学書院, Aug. 2017
Japanese, 症例1:79歳女。意識障害と脱力を主訴とした。右前頸部に弾性硬の腫瘤を触知し、頸部エコーで甲状腺右葉背側に内部やや低エコー、甲状腺に一部入り込むような腫瘤性病変を認め、境界は不明瞭であった。造影CTでは同部位に造影不良の腫瘤性病変を認めた。血液検査では補正Ca値の上昇、intact-PTH値の異常高値、腎機能低下、血小板減少を認めた。症例2:72歳男。意識障害と全身倦怠感を主訴とした。頸部エコーで甲状腺右葉背側に境界明瞭、甲状腺を圧排する低エコー腫瘤を認め、造影CTでは同部位に造影効果やや不良の腫瘤性病変を認めた。血液検査では補正Ca値の上昇、intact-PTH値の異常高値、腎機能低下を認めた。2例ともに術前診断として右下副甲状腺がんを疑い、高Ca血病を補正後にen bloc切除(右副甲状腺腫瘍摘出術+甲状腺右葉合併切除+右気管前傍リンパ節郭清)を行った。病理診断は症例1は副甲状腺がん、症例2は副甲状腺腺腫であった。症例1は術後3年半に上縦隔に転移を認め摘出術を行ったが、以後は経過良好である。症例2は再発・転移は認めていない。

北海道大学病院における喉頭癌治療の現況　　　　　　　　　　　　　　　
中薗 彬, 水町 貴諭, 本間 明宏, 畠山 博充, 加納 里志, 古沢 純, 坂下 智博, 鈴木 章之, 福田 諭
耳鼻咽喉科展望, 60, 補冊1, 8, 9, 耳鼻咽喉科展望会, Jun. 2017
Japanese

喉頭腫瘍におけるHPV感染の検討　　　　　　　　　　　　　　　
水町 貴諭, 中薗 彬, 坂下 智博, 加納 里志, 畠山 博充, 本間 明宏, 福田 諭
日本気管食道科学会会報, 67, 2, s61, s61, (NPO)日本気管食道科学会, Apr. 2016
Japanese

頭頸・口腔 頭頸部がん治療の個別化を目指して 北海道・東北地区における喉頭癌治療の臨床統計　　　　　　　　　　　　　　　
那須 隆, 野村 研一郎, 中薗 彬, 山田 和之, 小柴 茂, 阿部 尚央, 飯川 延子, 及川 伸一, 東 賢二郎, 池田 怜吉, 浅田 行紀, 千田 邦明, 多田 靖宏, 欠畑 誠治
日本癌治療学会誌, 50, 3, 2072, 2072, (一社)日本癌治療学会, Sep. 2015
Japanese

頭頸部癌化学放射線療法におけるEPA高配合栄養機能食品(プロシュア)の有用性の検討　　　　　　　　　　　　　　　
水町 貴諭, 中薗 彬, 坂下 智博, 加納 里志, 畠山 博充, 本間 明宏, 福田 諭
日本気管食道科学会会報, 66, 2, s20, s20, (NPO)日本気管食道科学会, Apr. 2015
Japanese

喉頭癌T1症例の臨床的検討
水町 貴諭, 中薗 彬, 溝口 兼司, 坂下 智博, 加納 里志, 畠山 博充, 本間 明宏, 福田 諭
日本耳鼻咽喉科学会会報, 118, 4, 504, 504, (一社)日本耳鼻咽喉科学会, Apr. 2015
Japanese

Introduction of percutaneous dilational tracheotomy in otolaryngology residency training
Yasushi Furuta, Nayuta Tsushima, Akira Nakazono, Atsushi Fukuda, Shogo Kimura, Hiroki Takahashi, Takashi Tsubuku, Michiya Matsumura
Journal of Otolaryngology of Japan, 118, 12, 1443, 1448, Oto-Rhino-Laryngological Society of Japan Inc., 2015, [Domestic magazines]
Japanese, Scientific journal

Introduction of percutaneous dilational tracheotomy in otolaryngology residency training
Yasushi Furuta, Nayuta Tsushima, Akira Nakazono, Atsushi Fukuda, Shogo Kimura, Hiroki Takahashi, Takashi Tsubuku, Michiya Matsumura
Journal of Otolaryngology of Japan, 118, 12, 1443, 1448, Oto-Rhino-Laryngological Society of Japan Inc., 2015, [Peer-reviewed]
Japanese, Scientific journal

気管切開術を施行した気道熱傷21症例の臨床的検討　　　　　　　　　　　　　　　
上埜 博史, 吉村 理, 原 敏浩, 瀧 重成, 中薗 彬
日本気管食道科学会会報, 64, 2, s33, s33, (NPO)日本気管食道科学会, Apr. 2013
Japanese

当科における声門閉鎖術後経過の検討
津布久 崇, 中薗 彬, 松村 道哉, 古田 康
日本耳鼻咽喉科学会会報, 115, 4, 463, 463, (一社)日本耳鼻咽喉科学会, Apr. 2012
Japanese

甲状腺低分化癌に対する放射線治療後に頸椎炎から咽後膿瘍をきたした一例　　　　　　　　　　　　　　　
中薗 彬, 対馬 那由多, 津布 久崇, 松村 道哉, 古田 康, 安川 真一郎, 坂下 智博, 畠山 博充, 折舘 伸彦, 福田 諭
北海道医学雑誌, 86, 6, 304, 304, 北海道医学会, Nov. 2011
Japanese

内視鏡下切除を施行した鼻腔・篩骨洞癌症例の検討　　　　　　　　　　　　　　　
中薗 彬, 津布 久崇, 松村 道哉, 古田 康
頭頸部癌, 37, 2, 300, 300, (一社)日本頭頸部癌学会, May 2011
Japanese

喉頭癌T1症例の検討　　　　　　　　　　　　　　　
中薗 彬, 折舘 伸彦, 本間 明宏, 坂下 智博, 鬼丸 力也, 福田 諭
日本気管食道科学会会報, 62, 2, 261, 262, (NPO)日本気管食道科学会, Apr. 2011
Japanese

鼻中隔尾側弯曲(前弯)の客観的評価と適切な鼻中隔矯正術の術式選択
木村将吾, 中丸裕爾, 鈴木正宣, 本間あや, 中薗彬, 本間明宏, 日本耳鼻咽喉科学会会報, 124, 4, 2021

Granulomatosis with Polyangiitis (GPA) Occurring with Binocular Visual Acuity Impairment
吉村淳, 鈴木正宣, 中丸裕爾, 鈴木崇祥, 本間あや, 中薗彬, 木村将吾, 本間明宏, 中里信一, 岡田宏美, 耳鼻咽喉科臨床, 114, 2, 2021

Inferior turbinate shoulder osteotomy in a patient with a narrow nasal cavity
田中大地, 中丸裕爾, 鈴木正宣, 本間あや, 中薗彬, 木村将吾, 本間明宏, 耳鼻咽喉科・頭頚部外科, 93, 6, 2021

A case of nasal septal perforation closure using unilateral mucosal flap based on the anterior ethmoidal artery
勝俣量平, 鈴木正宣, 中薗彬, 中丸裕爾, 本間明宏, 耳鼻咽喉科・頭頚部外科, 92, 9, 2020

低亜鉛が鼻粘膜のサイトカイン産生と炎症細胞浸潤に及ぼす影響
鈴木正宣, 中丸裕爾, 本間あや, 中薗彬, 木村将吾, RAMENZANPOIR Mahnaz, VREUGDE Sarah, WORMALD Peter-John, 本間明宏, 日本耳鼻咽喉科免疫アレルギー学会プログラム・抄録集, 38th, 2020

狭鼻を伴うアレルギー性鼻炎,慢性副鼻腔炎に対して下甲介shoulder osteotomyを施行した1例
田中大地, 中丸裕爾, 鈴木正宣, 本間あや, 中薗彬, 木村将吾, 本間明宏, 日本耳鼻咽喉科免疫アレルギー学会プログラム・抄録集, 38th, 2020

Endoscopic skull base surgery for Olfactory Neuroblastoma
茂木洋晃, 山口秀, 伊師雪友, 岡本迪成, 澤谷亮介, 中薗彬, 鈴木正宣, 中丸裕爾, 本間明宏, 日本神経内視鏡学会プログラム・抄録集, 27th, 2020

当院における外鼻形成術および鼻中隔矯正術施行例の検討
木村将吾, 中丸裕爾, 鈴木正宣, 本間あや, 中薗彬, 本間明宏, 日本鼻科学会会誌(Web), 58, 3, 2019

鼻粘膜において低亜鉛はコラーゲン産生を抑制する
鈴木正宣, 中丸祐爾, MAHNAZ Ramezanpour, 鈴木崇祥, 中薗彬, WORMALD Peter-john, VREUGDE Sarah, 本間明宏, 日本耳鼻咽喉科学会会報, 122, 4, 2019

鼻粘膜において低亜鉛はコラーゲン産生を抑制する
鈴木正宣, 鈴木正宣, 中丸裕爾, RAMEZANPOUR Mahnaz, 中薗彬, WORMALD Peter-John, VREUGDE Sarah, 本間明宏, 日本耳鼻咽喉科免疫アレルギー学会プログラム・抄録集, 37th, 2019

鼻粘膜において低亜鉛はコラーゲン産生を抑制する
鈴木正宣, 鈴木正宣, 中丸裕爾, RAMEZANPOUR Mahnaz, 中薗彬, WORMALD Peter-John, VREUDGE Sarah, 本間明宏, 耳鼻咽喉科免疫アレルギー(Web), 37, 2, 2019

篩骨動脈を茎とする鼻中隔粘膜弁を用いた鼻中隔穿孔閉鎖術の1例
勝俣量平, 鈴木正宣, 中薗彬, 中丸裕爾, 本間明宏, 日本鼻科学会会誌(Web), 57, 3, 2018

当院における嗅神経芽細胞腫の治療方針と成績
中薗彬, 中丸裕爾, 鈴木正宣, 水町貴諭, 高木大, 本間明宏, 日本鼻科学会会誌(Web), 57, 3, 2018

喉頭癌T1症例の検討
中薗彬, 折舘伸彦, 本間明宏, 坂下智博, 鬼丸力也, 福田諭, 日本気管食道科学会総会ならびに学術講演会プログラム・予稿集, 62nd, 116, 2010
Japanese

ウォーモルド直伝内視鏡下鼻副鼻腔手術トレーニング
鈴木, 正宣, 中薗, 彬, 志津木, 健, 本間, 明宏, 中丸, 裕爾
医学書院, Jan. 2024, 9784260052405, x, 252p, Japanese, [Joint work]

Peter-John Wormald Endoscopic Sinus Surgery Anatomy, Three-Dimensional Reconstruction, and Surgical Technique 4th edition
鈴木正宣, 本間明宏, 中丸裕爾, 7. 前頭洞手術(p87-108), 10. 蝶口蓋動脈結紮とVidian神経切除術(p147-157), 20. 内視鏡下前頭蓋底腫瘍摘出術(p271-287)
P. J. Wormald, 医学書院, Sep. 2020, 9784260042000, xvi, 309p, Japanese, [Joint translation]

鼻腔組織からのRNA抽出およびqPCR解析　　　　　　　　　　　　　　　
中薗 彬, 鈴木 正宣
第61回日本鼻科学会, 13 Oct. 2022, Public discourse
13 Oct. 2022 - 15 Oct. 2022

内視鏡下頭蓋底手術を考慮した嗅神経芽細胞腫に対する新規病期分類の検討　　　　　　　　　　　　　　　
中薗 彬, 中丸裕爾, 鈴木正宣, 本間あや, 木村将吾, 本間明宏
第123回日本耳鼻咽喉科頭頸部外科学会. 神戸, 2022.5.25-28, 26 May 2022
25 May 2022 - 26 May 2022

鼻粘膜上皮細胞での細菌;ウィルス結合受容体発現に対する自然免疫シグナルの影響　　　　　　　　　　　　　　　
中薗 彬,木村 将吾,本間 あや,鈴木 正宣,中丸 裕爾,本間 明宏
第2回日本耳鼻咽喉科免疫アレルギー感染症学会
14 Apr. 2022 - 16 Apr. 2022

A new staging system for olfactory neuroblastoma　　　　　　　　　　　　　　　
Nakazono A
JKJM2022（18th Japan-Korea Joint Meeting of Otorhinolaryngology - Head and Neck Surgery）
06 Apr. 2022 - 08 Apr. 2022

鼻腔組織からのRNA抽出およびqPCR解析　　　　　　　　　　　　　　　
中薗 彬, 鈴木 正宣
第60回日本鼻科学会/20th ARSR, 23 Sep. 2021, Nominated symposium
23 Sep. 2021 - 25 Sep. 2021

中薗 彬;鈴木正宣;木村将吾;本間あや;中丸裕爾;本間明宏　　　　　　　　　　　　　　　
鼻腔粘膜上皮細胞における新型コロナウィルス細胞侵入因子の発現制御機構
第1回日本耳鼻咽喉科免疫アレルギー感染症学会
30 Jun. 2021 - 02 Jul. 2021

Comparison of clinical characteristics of the;nasal manifestations of eosinophilic granulomatosis with;polyangiitis (EGPA;eosinophilic chronic rhinosinusitis (ECRS　　　　　　　　　　　　　　　
中薗 彬, 鈴木正宣, 木村将吾, 本間あや, 中丸裕爾, 本間明宏
JSA/WAO Joint Congress 2020（世界・日本アレルギー学会)
17 Sep. 2020 - 20 Oct. 2020

当院における嗅神経芽細胞腫の治療方針と成績　　　　　　　　　　　　　　　
中薗 彬, 中丸裕爾, 鈴木正宣, 水町貴諭, 髙木 大, 本間明宏
第57回日本鼻科学会, 旭川, 2018.9.27-29
27 Sep. 2018 - 29 Sep. 2018

中薗 彬　　　　　　　　　　　　　　　
超選択的動注化学療法と放射線治療の同時併用療法の患者管理, 北海道大学の方法
「頭頚部癌に対する超選択的動注化学療法と放射線治療の同時併用療法を実際に行うために」（平成30年度日本医療研究開発機構研究費（革新的がん医療実用化研究事業）, 19 May 2018

Compress or not compress surgical site: retrospective analysis of post-thyroidectomy hematoma,　　　　　　　　　　　　　　　
Nakazono A, Dochi H, Tsubuku T, Matsumura M, Furuta Y, Homma A, Fukuda S
2nd Congress of Asia-Pacific Society of Thyroid Surgery
01 Nov. 2017 - 03 Nov. 2017

北海道大学病院における口腔癌の治療成績　　　　　　　　　　　　　　　
中薗 彬, 本間明宏, 加納里志, 水町貴諭, 鈴木崇祥, 安川真一郎
第23回北日本頭頸部癌治療研究会, 14 Oct. 2017

中薗 彬　　　　　　　　　　　　　　　
超選択的動注化学療法と放射線治療の同時併用療法の患者管理, 北海道大学の方法
「頭頸部癌に対する超選択的動注化学療法と放射線治療の同時併用療法を実際に行うために」（平成29年度日本医療研究開発機構研究費（革新的がん医療実用化研究事業）, 23 Sep. 2017

甲状腺術後血腫の検討;創部圧迫の有無による差異について　　　　　　　　　　　　　　　
中薗 彬, 土地宏朋, 津布久崇, 松村道哉, 古田 康
第35回北海道甲状腺談話会, 札幌, 2017.7.22, 22 Jul. 2017

中薗 彬;土地宏朋;津布久崇;松村道哉;古田 康　　　　　　　　　　　　　　　
甲状腺術後血腫の検討, 創部圧迫の有無による差異について
第215回日本耳鼻咽喉科学会北海道地方部会, 26 Mar. 2017

甲状腺術後血腫の検討;創部圧迫の有無による差異について　　　　　　　　　　　　　　　
中薗 彬, 土地宏朋, 津布久崇, 松村道哉, 古田 康
第27回日本頭頸部外科学会
02 Feb. 2017 - 03 Feb. 2017

Prognostic Factors of T3 Laryngeal Cancer by T3 Determining Factors,　　　　　　　　　　　　　　　
Nakazono A, Mizumachi T, Homma A, Hatakeyama H, Kano S, Furusawa J, Sakashita T, Onimaru R, Tsuchiya K, Yasuda K, Shirato H, Fukuda S
The Joint Meeting of 4th Congress of Asian Society of Head and Neck Oncology & 39th Annual Meeting of Japan Society for Head and Neck Cancer(ASHNO).
03 Jun. 2015 - 06 Jun. 2015

北海道大学病院における喉頭癌治療の現況　　　　　　　　　　　　　　　
中薗 彬, 水町貴諭, 本間明宏, 畠山博充, 加納里志, 古沢 純, 坂下智博, 鈴木章之, 福田 諭
第20回北日本頭頸部癌治療研究会, 25 Oct. 2014

骨膜下膿瘍を呈した小児急性乳様突起炎の一例　　　　　　　　　　　　　　　
中薗 彬, 宮腰浩世, 及川敬太
第208回日本耳鼻咽喉科学会北海道地方部会, 16 Mar. 2014

中薗 彬;上埜博史;瀧 重成;原 敏浩;吉村 理　　　　　　　　　　　　　　　
当院における腎移植後遷延性副甲状腺機能亢進症に対する副甲状腺全摘術の検討
第207回日本耳鼻咽喉科学会北海道地方部会, 27 Mar. 2013

上部消化管内視鏡検査により発症した披裂軟骨脱臼の一例　　　　　　　　　　　　　　　
中薗 彬, 津布久崇, 松村道哉, 古田 康, 折舘伸彦
第205回日本耳鼻咽喉科学会北海道地方部会, 25 Mar. 2012

内視鏡下切除を施行した鼻腔・篩骨洞癌症例の検討　　　　　　　　　　　　　　　
中薗 彬, 津布久崇, 松村道哉, 古田 康
第205回北海道頭頸部腫瘍研究会, 03 Mar. 2012

高度肥満症例に対する経皮的気管切開（PDT）と外科的気管切開のHYBRID法によるアジャストフィット留置術　　　　　　　　　　　　　　　
中薗 彬, 津布久崇, 松村道哉, 古田 康
第22回日本頭頸部外科学会総会, 27 Jan. 2012

甲状腺低分化がんに対する放射線治療後に頸椎炎から咽後膿瘍をきたした一例　　　　　　　　　　　　　　　
中薗 彬, 対馬那由多, 津布久崇, 松村道哉, 古田 康, 安川真一郎, 坂下智博, 畠山博充, 折舘伸彦, 福田 諭
第29回北海道甲状腺談話会, 23 Jul. 2011

喉頭癌T1症例の検討　　　　　　　　　　　　　　　
中薗 彬, 坂下智博, 加納里志, 古沢 純, 水町貴諭, 鈴木清護, 本間明宏, 折舘伸彦, 福田 諭
第62回日本気管食道科学会
04 Nov. 2010 - 05 Nov. 2010