Tohyama Harukazu

Faculty of Health Sciences Health Sciences Department of Rehabilitation ScienceProfessor
Last Updated :2026/04/15

■Researcher basic information

Degree

  • Ph.D. (Medicine), Hokkaido University, Sep. 1996

Researchmap personal page

Researcher number

  • 60301884

Research Keyword

  • Sports injury
  • Ligament
  • Tendon
  • Biomchanics
  • Rehabilitation
  • Anterior cruciate ligament (ACL)
  • Tendon & Liugament
  • Tissue Engineering
  • Sprts Medicine

Research Field

  • Life sciences, Sports science
  • Life sciences, Rehabilitation science
  • Life sciences, Biomedical engineering
  • Life sciences, Orthopedics

Educational Organization

■Career

Career

  • Apr. 2026 - Present
    Hokkaido University, Faculty of Health Sciences, Specially Appointed Professor, Professor Emeritus of Hokkaido University, Japan
  • Apr. 2024 - Present
    Hachinohe Gakuin University, Faculty of Health Care Medicine, Visiting Professor
  • Apr. 2022 - Mar. 2026
    北海道大学病院, 安全衛生管理室, 産業医
  • Apr. 2020 - Mar. 2026
    Professor, Department of Rehabilitation Science, Faculty of Health Sciences, Hokkaido University
  • Apr. 2019 - Mar. 2026
    Hokkaido University, Sports Training Center, Institute for the Advancement of Higher Education, Director
  • Apr. 2023 - Mar. 2025
    Hokkaido University, Graduate School of Health Sciences, 副学院長
  • Apr. 2016 - Mar. 2020
    Hokkaido University, Faculty of Health Sciences, Vice Dean
  • Apr. 2013 - Mar. 2020
    Faculty of Health Sciences, Professor
  • Aug. 2007 - Mar. 2013
    Devision of Rehabilitation, Hokkaido University Hospital, Associate Professor
  • Apr. 2001 - Jul. 2007
    Hokkaido University School of Medicine, Hokkaido University School of Medicine, Associate Professor
  • Feb. 1999 - Mar. 2001
    Hokkaido University School of Medicine, Hokkaido University School of Medicine, Lecturer
  • Apr. 1998 - Jan. 1999
    Hokkaido University School of Medicine, Hokkaido University School of Medicine, Assistant Professor
  • Mar. 1993 - Mar. 1994
    Orthopaedic Research Laboratory, Columbia University, New York, NY, U.S.A., Research fellow
  • May 1991 - Feb. 1993
    Orthopaedics & Rehabilitation, University of Vermont, Burlington, VT, U.S.A., Research fellow
  • Apr. 1985 - Apr. 1991
    Department of Orthopaedic Surgery, Hokkaido University Hospital, Resident

Educational Background

  • 1985, Hokkaido University, School of Medicine, 医学科, Japan

Committee Memberships

  • Dec. 2025 - Present
    The Japanese Knee Society, Honorary Member, Society
  • Jun. 2025 - Present
    Japan Sports Orthopaedic Association (JAOA), Honorary Member, Society
  • Jun. 2023 - Present
    公益財団法人 北海道スポーツ協会, スポーツ科学委員会 副委員長, Society
  • Jan. 2019 - Present
    北海道, 国民健康保険診療報酬審査委員会, Autonomy
  • Nov. 2018 - Present
    日本整形外科学会, 変形性膝関節症診療ガイドライン策定委員会委員, Society
  • Present
    日本臨床バイオメカニクス学会, 評議員, Society
  • Present
    日本運動器科学会, 評議員, Society
  • Present
    日本臨床スポーツ医学会, 評議員, Society
  • Jul. 2023 - Mar. 2026
    スポーツ庁「地域におけるスポーツ医・科学サポート体制構築事業」, 北海道スポーツ医・科学コンソーシアム専門委員会 副委員長, Others
  • 2023 - 2025
    日本スポーツ整形外科学会, 代議員, Society
  • 2023 - 2025
    日本膝関節学会, 評議員
  • 2023 - 2025
    日本膝関節学会, 用語・機能評価委員会委員, Society
  • 2023 - 2025
    日本膝関節学会, 将来構想委員会委員, Society
  • 2016 - Sep. 2024
    日本内視鏡外科学会, ガイドライン委員会委員, Society
  • Apr. 2021 - Mar. 2023
    Japanese Society for Medical and Biological Engineering, 2021-2022 delegate, Society
  • 2014 - 2023
    日本関節鏡・膝・スポーツ整形外科学会(JOSKAS), 機能評価委員会委員, Society
  • 2014 - 2023
    日本関節鏡・膝・スポーツ整形外科学会(JOSKAS), 将来構想委員会委員, Society
  • 2023
    日本整形外科スポーツ医学会, 評議員, Society
  • Jun. 2021 - Jun. 2022
    日本関節鏡・膝・スポーツ整形外科学会(JOSKAS), 会長, Society
  • 2016 - Jun. 2022
    日本関節鏡・膝・スポーツ整形外科学会(JOSKAS), 理事, Society
  • Aug. 2018 - Jul. 2021
    日本体力医学会北海道地方会, 会長, Society
  • 2015 - 2019
    日本整形外科学会, 中央資格認定委員会委員, Society
  • 2015 - 2019
    日本整形外科学会, 北海道地区資格認定委員会委員長, Society
  • 2015 - 2019
    日本整形外科学会, 代議員, Society

Position History

  • 大学院保健科学研究院副研究院長, 2018年4月1日 - 2020年3月31日
  • 大学院保健科学副学院長, 2023年4月1日 - 2025年3月31日

■Research activity information

Awards

  • Nov. 2021, International Society of Arthroscopy, Knee Surgery and Orthopaedic Sports Medicine (ISAKOS), Achilles Orthopaedic Sports Medicine Research Award               
    Harukazu Tohyama
  • Nov. 2020, Clinical Orthopaedics and Related Research, Top CORR reviewers for 2020               
    Harukazu Tohyama
  • Oct. 2019, Arthroscopy, AANA, and Elsevier, 2018 Arthroscopy Excellence in Reviewing               
  • Mar. 2008, ACL Study Group, Traveling Scientist               
  • Mar. 2004, JOA/AOA, Traveling Fellow               
  • Feb. 2003, 日本膝関節学会, The best paper of the year, basic               
  • Feb. 2002, 北海道整形災害外科学会, 学術奨励賞               
  • Dec. 1997, 日本膝関節研究会, 廣畑賞               

Papers

  • Contextual interference enhances vertical transfer of fine motor skill from upper to lower limbs
    Satoshi Kasahara, Hiroshi Saito, Linjing Jiang, Kazumasa Yoshimi, Shikino Abe, Tomoya Ishida, Yuta Koshino, Mina Samukawa, Harukazu Tohyama
    Human Movement Science, 105, 103428, 103428, Elsevier BV, Feb. 2026, [Peer-reviewed], [Last author]
    Scientific journal
  • Reducing attention bias toward negative emotional stimuli with transcranial random noise stimulation: a randomized, double-blind, sham-controlled, crossover study.
    Daisuke Sawamura, Miaowen Duan, Yuji Inagaki, Ryuji Saito, Kazufumi Okada, Akihiro Watanabe, Harukazu Tohyama, Takaya Maeyama, Susumu Yoshida, Mitsunori Miyazaki, Naoya Hasegawa, Koichi Yokosawa, Yumie Ono
    Scientific reports, 12 Dec. 2025, [Peer-reviewed], [International Magazine]
    English, Scientific journal
  • Effects of landing instructions on Achilles tendon load: Emphasising hip flexion as the optimal strategy.
    Yuta Koshino, Mina Samukawa, Tomoya Ishida, Harukazu Tohyama
    Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 29 Aug. 2025, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, PURPOSE: Managing Achilles tendon (AT) load during dynamic activities is essential for preventing and rehabilitating Achilles tendinopathy. While various exercises have been studied, the impact of verbal instructions on landing mechanics remains unclear. This study aimed to identify instructional methods that effectively reduce AT load during drop vertical jumps (DVJs). METHODS: Twenty-three healthy participants performed DVJs under five instructional conditions: (1) natural: no instruction; (2) posterior-centre of pressure (COP): shifting the COP posteriorly; (3) hip-flexion: increasing hip flexion; (4) knee-flexion: increasing knee flexion; and (5) quiet-landing: minimising landing sound. A three-dimensional motion analysis system recorded peak AT force, loading rate, joint angles, ground reaction force (GRF) and COP position. Data were analysed using the Friedman test, the Wilcoxon signed-rank test with Holm's correction and effect size (ES). RESULTS: Peak AT force was significantly lower in hip-flexion and posterior-COP compared to natural (p < 0.001, ES = -0.87 and -0.82, respectively). Hip-flexion also showed lower AT force than the knee-flexion and quiet-landing (p < 0.01). Loading rates were lower in hip-flexion (ES = -0.73) and quiet-landing (ES = -0.64) than in natural (p < 0.01) but were higher in posterior-COP than hip-flexion (p = 0.042). Hip-flexion, knee-flexion and quiet-landing increased hip flexion (p < 0.001), while knee-flexion and quiet-landing increased knee flexion (p < 0.001) compared to natural. Posterior-COP resulted in decreased hip, knee and ankle flexion, increased vertical GRF and a more posterior COP position compared to the other conditions (p < 0.05). Vertical GRF was lower in hip-flexion, knee-flexion and quiet-landing than in natural (p < 0.005). CONCLUSIONS: Increasing hip flexion is the most effective strategy for reducing AT force during landing, and may aid in the prevention and rehabilitation of Achilles tendinopathy. Although a posterior COP shift lowers AT force, it increases AT loading rate and GRF, potentially elevating injury risk. LEVEL OF EVIDENCE: Level III.
  • Acute Effects of Static Stretching on Submaximal Force Control of the Ankle
    Fuma Sentoku, Yuta Koshino, Masahiro Sato, Tomoya Ishida, Satoshi Kasahara, Harukazu Tohyama, Mina Samukawa
    Applied Sciences, 15, 13, 7294, 7294, MDPI AG, 28 Jun. 2025
    Scientific journal, Static stretching (SS) is widely used in clinical and sports settings. However, the acute effects on neuromuscular control during dynamic tasks remain unclear. This study aimed to examine the immediate effects of SS on force control using a randomized crossover design. Seventeen healthy young males performed low-range (10–30% of maximal voluntary isometric contraction: MVIC) and high-range (40–60% MVIC) isometric force tracking tasks. In the SS condition, the ankle plantar flexors were stretched for 60 s; in the control condition, the participants remained at rest. The primary outcomes included ankle dorsiflexion range of motion (ROM), musculotendinous stiffness, and the root mean square error (RMSE) of force tracking. Compared to the control group, SS significantly increased dorsiflexion ROM and reduced musculotendinous stiffness. A significant reduction in the RMSE was observed during the force release phase when participants smoothly decreased force output in the high-range task following SS (p = 0.030, d = 0.79), but no significant changes were found during the force generation phase in the high-range task or during either phase (generation or release) in the low-range task. These findings suggest that a brief SS intervention may acutely refine the dynamic force control under high neuromuscular demands. Therefore, SS may enhance motor control in tasks that involve submaximal force modulation.
  • Postoperative Knee Extensor Strength After Medial Patellofemoral Ligament Reconstruction Using Superficial Slip of the Quadriceps Tendon and the Factors That Affect Strength Recovery.
    Chiharu Inoue, Yoshimitsu Aoki, Kazunori Yasuda, Eiji Kondo, Satoru Kaneko, Harukazu Tohyama, Masayuki Inoue, Tomononori Yagi
    Orthopaedic journal of sports medicine, 13, 4, 23259671251325748, 23259671251325748, Apr. 2025, [International Magazine]
    English, Scientific journal, BACKGROUND: Medial patellofemoral ligament reconstruction (MPFLR) using the quadriceps tendon can avoid complications related to the fixation of other graft types to the patella. However, there is concern about postoperative loss of knee extensor muscle strength because of harvesting a portion of the quadriceps tendon. HYPOTHESIS: Knee extensor muscle strength after superficial slip of the quadriceps tendon MPFLR (SQ-MPFLR) decreases postoperatively, and there are specific factors that effect knee extensor muscle strength recovery. STUDY DESIGN: Case series study; Level of evidence 4. METHODS: A total of 26 patients who underwent unilateral primary SQ-MPFLR were enrolled. Clinical and functional outcomes were evaluated using the Kujala score and Tegner activity score preoperatively and 12 months postoperatively. Knee extensor muscle strength was examined preoperatively and 6 and 12 months postoperatively using the Biodex dynamometer. The knee muscle strength of the operated leg was compared with that of the contralateral leg using the limb symmetry index (LSI). The associations of sex, body mass index, and daily sports activity level with knee extensor muscle strengths at 6 and 12 months postoperatively were investigated and compared between the 2 groups. RESULTS: The preoperative mean Kujala score was 65.0 and significantly improved to 94.7 at 12 months after surgery (P < .001). The preoperative Tegner activity score was 5.6, and the 12-month postoperative score was 5.8. The knee extensor LSI increased from 69.2% preoperatively to 82.0% at 12 months postoperatively. The patient group with a high sports activity level had a significant higher knee extensor muscle LSI (mean, 87.8%) than the group with a low sports activity level at 12 months postoperatively (P = .003). CONCLUSION: The knee extensor LSI of patients who underwent SQ-MPFLR increased from 69.2% preoperatively to 82.0% postoperatively at 12 months. The patient group with a high sports activity level had a significantly higher knee extensor LSI than the group with a low sports activity level at 12 months after SQ-MPFLR surgery.
  • The Effect of Real-Time Feedback Regarding the Center-of-Pressure Position on Patellofemoral Joint Loading During Double-leg Squatting
    Tomoya Ishida, Ryo Ueno, Yu Kitamura, Yoshiki Yamakawa, Mina Samukawa, Harukazu Tohyama
    Orthopaedic Journal of Sports Medicine, 13, 3, SAGE Publications, 03 Mar. 2025, [Peer-reviewed], [Last author]
    Scientific journal, Background:

    Exercise therapy is the cornerstone of patellofemoral (PF) pain management. However, whether squat exercises are therapeutic or detrimental depends on their technique and the resulting load on the PF joint.

    Purpose/Hypothesis:

    The purpose of this study was to investigate whether real-time feedback to position the center-of-pressure (COP) anteriorly could reduce the PF joint reaction force and stress during bodyweight double-leg squatting. It was hypothesized that an anterior COP position would decrease the PF joint reaction force and stress without changing the trunk flexion angle, whereas a posterior COP position would increase the PF joint reaction force and stress.

    Study Design:

    Controlled laboratory study.

    Methods:

    Sixteen men (age, 22.9 ± 1.5 years; height, 173.6 ± 5.2 cm; and body mass, 63 ± 6.8 kg) performed double-leg squatting under 4 conditions—natural, anterior, middle, and posterior COP. Kinematic and kinetic data were obtained via standard 3-dimensional motion analysis and force plate data. The PF joint reaction force and stress were calculated via a musculoskeletal modeling approach.

    Results:

    PF joint loading was significantly reduced in the anterior and middle COP conditions compared with the natural condition. At 90° of knee flexion, the PF joint reaction force decreased by 11% and 9% in the anterior and middle COP conditions, respectively, compared with that in the natural condition (anterior: P < .001, 95% CI −0.996 to −0.277 bodyweight; middle: P = .011, 95% CI −0.795 to −0.087 bodyweight). Moreover, the peak PF joint stress decreased by 9% and 7% in the anterior and middle COP conditions, respectively, compared with the natural condition (anterior: P = .001, 95% CI −0.659 to −0.146 MPa; middle: P = .023, 95% CI −0.600 to −0.036 MPa). Compared with those under the natural condition, the trunk forward inclination angles did not increase under anterior or middle COP conditions.

    Conclusions:

    Real-time feedback for anterior COP positioning is an effective strategy for reducing the PF joint reaction force and stress during double-leg squatting without increasing trunk forward lean.

    Clinical Relevance:

    The incorporation of real-time feedback regarding the anteroposterior COP position is useful for reducing PF joint loading during double-leg squatting, which may be helpful in the rehabilitation of PF pain patients. Instructions to position the COP anteriorly may also be useful in reducing PF joint loading during double-leg squatting.
  • Relationship Between Vertical Ground Reaction Force and Acceleration from Wearable Inertial Measurement Units During Single-Leg Drop Landing After Anterior Cruciate Ligament Reconstruction
    Makoto Suzuki, Tomoya Ishida, Hisashi Matsumoto, Kenichiro Kondo, Shota Yamaguchi, Satoru Kaneko, Chiharu Inoue, Yoshimitsu Aoki, Harukazu Tohyama, Mina Samukawa
    Applied Sciences, 15, 3, 1583, 04 Feb. 2025, [Peer-reviewed]
    English, Scientific journal
  • Foot Flexibility and Alignment Are Weakly Correlated with Multisegment Foot Kinematics During the Landing Task.
    Yuya Ezawa, Yuta Koshino, Masanori Yamanaka, Takumi Okunuki, Mina Samukawa, Takeo Maruyama, Harukazu Tohyama
    Journal of the American Podiatric Medical Association, 115, 2, 2025, [International Magazine]
    English, Scientific journal, BACKGROUND: Flat feet show increased foot motion during dynamic tasks. Although the increased motion is one of the risk factors for sports-related injuries, few studies have investigated how foot flexibility affects foot kinematics during landing. This study aimed to investigate the relationship between foot alignment, foot flexibility, and multisegment foot kinematics during a double-leg landing task in healthy participants. METHODS: Thirty-eight healthy volunteers (50% female) participated in this study. Their mean ± SD age was 22.0 ± 1.3 years; height, 166.1 ± 8.9 cm; and mass, 57.5 ± 8.8 kg. Foot alignment and flexibility were assessed using normalized navicular height truncated (NNHt) and the navicular drop (ND) test, respectively. A multisegment foot model was used to record shank, rearfoot, midfoot, and forefoot motion during drop landing from a height of 30 cm. Peak angle and range of motion were measured for each segment from the initial contact to 200 msec after landing. The relationships between NNHt, ND, and foot kinematics were explored. RESULTS: The NNHt was significantly correlated with peak rearfoot eversion angle (r = -0.353). The ND test values were significantly correlated with midfoot dorsiflexion and forefoot inversion excursion (r = 0.364 and 0.356, respectively). No significant correlation was found for the other kinematic outcomes. CONCLUSIONS: Foot alignment and flexibility should be evaluated separately because these foot measurements were correlated with different foot motions. However, it may be difficult to predict foot motion during the landing task by evaluating foot alignment and flexibility.
  • Integrating Motor Learning Principles into Muscle Force and Balance Control.
    Yuting Wei, Satoshi Kasahara, Linjing Jiang, Ami Chiba, Tomoya Ishida, Yuta Koshino, Mina Samukawa, Hiroshi Saito, Harukazu Tohyama
    Journal of motor behavior, 57, 4, 391, 399, 2025, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, The principles of specificity and similarity play a crucial role in supporting the transfer and retention of motor performance in general sports training. Nevertheless, the extent to which force control ability translates into dynamic performance remains unclear. We aimed to investigate the effect of force control training on the transfer and retention of balance control in 18 young individuals. The force control training utilized a visual-guided force tracking task with either a uniform or non-uniform sinusoidal wave in ankle plantar flexors (PF). Postural stability was assessed by measuring the center of pressure (COP) in a single-leg standing posture. Despite consistent repetitions, no significant differences in COP parameters were observed between the pre- and post-training assessments. However, significant differences were noted between the pre-training assessments and the post-training assessments conducted one week later, utilizing a randomized order. Shifting from a regimen of constant repetition to a randomized order has a positive impact on the transfer and retention of acquired motor skills. This approach, based on the motor learning theory, holds promise for enhancing the motor performance of athletes and patients undergoing rehabilitation.
  • Association Between Maturity Status, Landing Force, and Jump Performance in Adolescent Male Soccer Players.
    Takahiro Namiki, Mina Samukawa, Eri Takagi, Tomoya Ishida, Mario Bizzini, Naoto Kyotani, Miho Komatsuzaki, Ginji Nara, Yuta Koshino, Satoshi Kasahara, Harukazu Tohyama
    International journal of sports physical therapy, 20, 8, 1131, 1141, 2025, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, BACKGROUND: Maturity status varies among adolescents of the same age, making age an unreliable indicator. Although maturity status affects movement patterns, differences in landing force and jump performance among maturity groups remain unclear. HYPOTHESIS/PURPOSE: This study compared landing force and jump performance during drop vertical jump in adolescent male soccer players based on classifications by maturity status and age. A hypothesis was formulated that landing force would be greater during the period of peak height velocity (PHV) and jump performance higher in the post-PHV group, showing clearer differences than age. STUDY DESIGN: Cross-sectional study. METHODS: Forty-five male soccer players (13.5 ± 0.9 years) were grouped by maturity status (pre-, circa-, and post-PHV), and by age. Landing forces (peak vertical ground reaction force [PVGRF], time to PVGRF, and loading rate) and jump performance (jump height, contact time, reactive strength index [RSI], PVGRF, and power) were measured using a force plate. A one-way analysis of variance was performed to detect group differences. RESULTS: Landing forces showed no significant differences among maturity groups (PVGRF: p = 0.190; time to PVGRF: p = 0.122; and loading rate: p = 0.255). Jump height was greater in post-PHV (32.87 ± 4.18 cm) than in pre-PHV (25.17 ± 4.85 cm, p = 0.001). RSI was higher in post- (1.33 ± 0.31 m/s) than in pre- (1.00 ± 0.29 m/s, p = 0.024) and circa-PHV groups (1.02 ± 0.23 m/s, p = 0.021). Power was greater in post- (40.40 ± 6.31 W/kg) than in pre- (33.15 ± 7.78 W/kg, p = 0.045) and circa-PHV groups (33.59 ± 5.50 W/kg, p = 0.037). Age-related differences were found only in jump height (p < 0.001). CONCLUSION: Maturity status classification detected significant group differences in jump height, RSI, and power, but age classification only detected a significant group difference in jump height. LEVEL OF EVIDENCE: 3.
  • Relationship Between Quadriceps Strength at 6 Months Postoperatively and Improvement in Patient-Reported Knee Function After Anterior Cruciate Ligament Reconstruction.
    Tomoya Ishida, Makoto Suzuki, Hisashi Matsumoto, Mina Samukawa, Satoru Kaneko, Chiharu Inoue, Yoshimitsu Aoki, Harukazu Tohyama
    Orthopaedic journal of sports medicine, 13, 1, 23259671241305623, 23259671241305623, Jan. 2025, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, BACKGROUND: Understanding the factors associated with poor recovery over time after anterior cruciate ligament reconstruction (ACLR) helps clinicians identify patients who are at risk and targets for an intervention. PURPOSE: To determine the factors associated with improvement in subjective knee function from 6 to 12 months after ACLR. STUDY DESIGN: Case-control study; Level of evidence, 3. METHODS: A total of 91 patients undergoing primary unilateral ACLR were included. Subjective knee function was assessed using the International Knee Documentation Committee Subjective Knee Form (IKDC-SKF) at 6 and 12 months postoperatively. Isokinetic knee strength (quadriceps and hamstring) and Anterior Cruciate Ligament-Return to Sport After Injury (ACL-RSI) scale scores were also assessed. Patients were included in the poor recovery group if their improvement in the IKDC-SKF score from 6 to 12 months was <15.5 points (minimal detectable change) and their IKDC-SKF score at 12 months was <90 points (maximum, 100 points). The IKDC-SKF score, knee strength, and the ACL-RSI score were compared between the poor recovery and good recovery groups with and without propensity score matching. Matched variables included age, sex, and IKDC-SKF score at 6 months after ACLR. In addition, logistic regression analysis was performed to identify factors that discriminated between the poor recovery and good recovery groups. RESULTS: There were 32 participants (35%) allocated to the poor recovery group. Before propensity score matching, the poor recovery group had a significantly older age, lower IKDC-SKF scores at 6 and 12 months, and a lower limb symmetry index (LSI) for quadriceps strength at 6 months. After propensity score matching, the LSI for quadriceps strength at 6 months was significantly different between the poor recovery and good recovery groups (73.0 ± 17.4 vs 83.3 ± 18.2, respectively; P = .039). Logistic regression analysis showed that a lower LSI for quadriceps strength at 6 months was significantly associated with poor recovery of the IKDC-SKF score (odds ratio, 0.96 [95% CI, 0.93-0.98]), and receiver operating characteristic curve analysis identified 80.9% as a cutoff value of the LSI for quadriceps strength with 75.0% sensitivity and 61.0% specificity. CONCLUSION: A lower LSI for quadriceps strength at 6 months postoperatively was associated with poor recovery of the IKDC-SKF score from 6 to 12 months after ACLR, even after adjusting for confounders.
  • The effects of intermittent and continuous dynamic stretching with a duration-matched protocol on range of motion and single-leg jump performance
    Kensuke Tsutsumi, Mina Samukawa, Kensuke Oba, Miho Komatsuzaki, Yuna Kamewari, Fuma Sentoku, Yuta Koshino, Tomoya Ishida, Satoshi Kasahara, Harukazu Tohyama
    Sport Sciences for Health, Springer Science and Business Media LLC, 08 Nov. 2024, [Peer-reviewed], [Last author]
    Scientific journal
  • Association Between Physical Activity and Performance in Skill Learning Among Older Adults Based on Cognitive Function.
    Satoshi Kasahara, Ami Chiba, Linjing Jiang, Tomoya Ishida, Yuta Koshino, Mina Samukawa, Hiroshi Saito, Harukazu Tohyama
    Journal of aging and physical activity, 1, 12, 28 Oct. 2024, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, BACKGROUND/OBJECTIVES: Most older adults experience cognitive and physical functioning problems; however, they require the ability to learn skills in response to age-related or social environmental changes for independent living. This study aimed to clarify the associations between age-related physical activity and performance in skill learning tasks based on cognitive function. METHODS: Fifty-eight adults participated in this study and were divided into two groups: the control group (aged under 65 years) and older adult group (aged over 65). All the participants performed two-skill learning exercises based on cognitive function. Habitual exercise was measured using an accelerometer and a self-reported questionnaire. RESULTS: At baseline, the scores on skill tasks were lower in the older adult group than in the control group and were associated with habitual exercise and motor performance. Skill acquisition, observed in both groups, was associated with age and self-reported physical activity. Retention of the acquired skill was not associated with habitual exercise, and it declined significantly in the older group. CONCLUSIONS: Skill acquisition was maintained regardless of age; however, the ability to retain the acquired skills decreased among the older adults. Habitual physical activity was associated with skill acquisition but not the retention of the acquired skill. Significance/Implications: The study findings highlight the association between habitual exercise and motor skill learning in older adults, providing insight for practitioners in the rehabilitation and health care fields.
  • Posterior Correction and Fusion Using a 4D Anatomical Spinal Reconstruction Technique Improves Postural Stability Under the Eye-Closed Condition in Patients with Adolescent Idiopathic Scoliosis.
    Satoshi Osuka, Hideki Sudo, Katsuhisa Yamada, Hiroyuki Tachi, Akira Fukushima, Hiroki Mani, Kentaro Watanabe, Fuma Sentoku, Takeshi Chiba, Hiroaki Hori, Norimasa Iwasaki, Masahiko Mukaino, Harukazu Tohyama
    Journal of clinical medicine, 13, 21, 24 Oct. 2024, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, Background: Patients with adolescent idiopathic scoliosis (AIS) has been reported to exhibit impaired postural stability. Posterior correction and fusion using four-dimensional (4D) anatomical spinal reconstruction techniques may improve postural stability to correct the spine for optimal anatomical alignment. This prospective study aimed to determine the effect of posterior correction and fusion using a 4D anatomical spinal reconstruction technique on postural stability in the eye-open and eye-closed standing position in patients with thoracic AIS. Methods: Thirty-three patients with AIS, excluding those with Lenke type 5C AIS, participated in the study. The mean and standard deviation of the minimum values of the time-to-boundary (TTB) were determined. All patients were asked to perform the quiet standing position under the eye-open and eye-closed condition on a force plate preoperatively and at 1 week and 2 years postoperatively. The TTB value was calculated from the velocity and distance to the foot boundary of the acquired center-of-pressure data. Results: Under the eye-closed condition, the mean and standard deviation of the minimum TTB were significantly higher at 2 years postoperatively than preoperatively and at 1 week postoperatively. The mean and standard deviation of the minimum TTB values were significantly lower at 1 week postoperatively than preoperatively. Conclusions: The results of this study suggest that surgery using the 4D anatomical spinal reconstruction technique reduces postural stability immediately after surgery; however, it improves postural stability at 2 years compared to the preoperative values.
  • Differing effectiveness of transcranial random noise stimulation and transcranial direct current stimulation for enhancing working memory in healthy individuals: a randomized controlled trial
    Yukina Tokikuni, Akihiro Watanabe, Hisato Nakazono, Hiroshi Miura, Ryuji Saito, Duan Miaowen, Kanako Fuyama, Keita Takahashi, Kazufumi Okada, Kazuhiro Sugawara, Harukazu Tohyama, Susumu Yoshida, Kenneth N. K. Fong, Daisuke Sawamura
    Journal of NeuroEngineering and Rehabilitation, 21, 1, Springer Science and Business Media LLC, 14 Oct. 2024, [Peer-reviewed]
    Scientific journal, Abstract

    Background

    Transcranial direct current stimulation (tDCS) applied to the left dorsolateral prefrontal cortex (DLPFC) is a promising technique for enhancing working memory (WM) performance in healthy and psychiatric populations. However, limited information is available about the effectiveness of transcranial random noise stimulation (tRNS) applied to the left DLPFC on WM. This study investigated the effectiveness of tRNS on WM compared with that of tDCS, which has established functional evidence.

    Methods

    This randomized, double-blind, sham-controlled trial enrolled 120 healthy right-handed adults who were randomly allocated to four stimulation groups: tRNS + direct current (DC) offset, tRNS, tDCS, or sham. Each stimulus was placed over the left DLPFC and had a current intensity of 2 mA applied for 20 min during the dual n-back task. The dual n-back task was repeated thrice: pre-stimulation, during stimulation, and post-stimulation. The d-prime scores, and response times were calculated as the main outcome measures. A linear mixed model was created to identify the main effects and interactions between the groups and times, with the group and time as fixed effects, and baseline performance and the subject as a covariate and random effect, respectively. The relationships between the benefit of each stimulus and baseline WM performance were also examined.

    Results

    For the d-prime score during stimulation, the tRNS group significantly performed better than the sham group at online assessment (β = 0.310, p = 0.001). In the relationships between the benefit of each stimulus and baseline WM performance, the tRNS group had significantly larger negative line slopes than the sham group for the d-prime score (β = −0.233, p = 0.038).

    Conclusions

    tRNS applied to the left DLPFC significantly improved WM performance and generated greater benefits for healthy individuals with lower WM performance. These findings highlight the potential utility of tRNS for enhancing WM performance in individuals with lower WM performance and contribute evidence for clinical application to patients with cognitive decline.

    Trial Registration

    This study was registered in the University Hospital Medical Information Network Clinical Trial Registry in Japan (UMIN000047365) on April 1, 2022; https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000054021.
  • Validity of Wearable Gait Analysis System for Measuring Lower-Limb Kinematics during Timed Up and Go Test
    Yoshiaki Kataoka, Tomoya Ishida, Satoshi Osuka, Ryo Takeda, Shigeru Tadano, Satoshi Yamada, Harukazu Tohyama
    Sensors, 24, 19, 6296, 6296, MDPI AG, 29 Sep. 2024, [Peer-reviewed], [Last author]
    Scientific journal, Few studies have reported on the validity of a sensor-based lower-limb kinematics evaluation during the timed up and go (TUG) test. This study aimed to determine the validity of a wearable gait sensor system for measuring lower-limb kinematics during the TUG test. Ten young healthy participants were enrolled, and lower-limb kinematics during the TUG test were assessed using a wearable gait sensor system and a standard optical motion analysis system. The angular velocities of the hip, knee, and ankle joints in sit-to-stand and turn-to-sit phases were significantly correlated between the two motion analysis systems (R = 0.612–0.937). The peak angles and ranges of motion of hip, knee, and ankle joints in the walking-out and walking-in phases were also correlated in both systems (R = 0.528–0.924). These results indicate that the wearable gait sensor system is useful for evaluating lower-limb kinematics not only during gait, but also during the TUG test.
  • Cervical motion analysis using wearable inertial sensors to patients with cervical ossification of posterior longitudinal ligament.
    Satoshi Osuka, Masahiko Takahata, Ryo Takeda, Takeshi Chiba, Hiroaki Hori, Yoshiaki Kataoka, Norimasa Iwasaki, Masahiko Mukaino, Harukazu Tohyama
    Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 29 Sep. 2024, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, This study aimed to clarify cervical kinematics during daily activities, including level walking and stair ascending, in patients with cervical ossification of the posterior longitudinal ligament (C-OPLL). Eighteen patients with myelopathy caused by C-OPLL and 18 healthy controls were recruited to participate in the study. The sagittal cervical kinematics during level walking and stair ascent were quantitatively assessed using a motion analysis system based on wearable inertial sensors. The Japanese Orthopaedic Association score, Japanese Orthopaedic Association Cervical Myelopathy Evaluation Questionnaire, Neck Disability Index, and deep sensation in the lower extremities were assessed in all participants. Nine of 18 patients with C-OPLL presented with deep sensory disturbances. Patients with C-OPLL with deep sensory disturbances exhibited different sagittal plane cervical motion patterns than healthy controls during level walking and stair ascent. During the first phase of stair ascent, both patients with C-OPLL and healthy controls flexed their necks to the same degree; however, during the middle and final phases of stair ascent and all phases of level walking, the mean cervical flexion angle of patients with C-OPLL with deep sensory disturbances was significantly higher than that of patients with C-OPLL without deep sensory disturbance and healthy controls. Our data suggest that patients with C-OPLL presenting with deep sensory disturbances are likely to walk with their necks flexed and gaze downward to observe their steps throughout their daily lives. This habitual neck posture may lead to a vicious cycle of cervical kyphosis and worsening of compressive myelopathy.
  • Effects of short-duration constant torque and constant angle stretching on the musculotendinous stiffness of ankle plantar flexors
    Kensuke Oba, Mina Samukawa, Satoshi Kasahara, Tomoya Ishida, Harukazu Tohyama
    Sport Sciences for Health, 21 Sep. 2024, [Peer-reviewed], [International Magazine]
    English, Scientific journal
  • Validity and Reliability of OpenPose-Based Motion Analysis in Measuring Knee Valgus during Drop Vertical Jump Test
    Takumi Ino, Mina Samukawa, Tomoya Ishida, Naofumi Wada, Yuta Koshino, Satoshi Kasahara, Harukazu Tohyama
    Journal of Sports Science and Medicine, 23, 1, 515, 525, Journal of Sports Science and Medicine, 09 Sep. 2024, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, OpenPose-based motion analysis (OpenPose-MA), utilizing deep learning methods, has emerged as a compelling technique for estimating human motion. It addresses the drawbacks associated with conventional three-dimensional motion analysis (3D-MA) and human visual detection-based motion analysis (Human-MA), including costly equipment, time-consuming analysis, and restricted experimental settings. This study aims to assess the precision of OpenPose-MA in comparison to Human-MA, using 3D-MA as the reference standard. The study involved a cohort of 21 young and healthy adults. OpenPose-MA employed the OpenPose algorithm, a deep learning-based open-source two-dimensional (2D) pose estimation method. Human-MA was conducted by a skilled physiotherapist. The knee valgus angle during a drop vertical jump task was computed by OpenPose-MA and Human-MA using the same frontal-plane video image, with 3D-MA serving as the reference standard. Various metrics were utilized to assess the reproducibility, accuracy and similarity of the knee valgus angle between the different methods, including the intraclass correlation coefficient (ICC) (1, 3), mean absolute error (MAE), coefficient of multiple correlation (CMC) for waveform pattern similarity, and Pearson’s correlation coefficients (OpenPose-MA vs. 3D-MA, Human-MA vs. 3D-MA). Unpaired t-tests were conducted to compare MAEs and CMCs between OpenPose-MA and Human-MA. The ICCs (1,3) for OpenPose-MA, Human-MA, and 3D-MA demonstrated excellent reproducibility in the DVJ trial. No significant difference between OpenPose-MA and Human-MA was observed in terms of the MAEs (OpenPose: 2.4° [95%CI: 1.9-3.0°], Human: 3.2° [95%CI: 2.1-4.4°]) or CMCs (OpenPose: 0.83 [range: 0.99-0.53], Human: 0.87 [range: 0.24-0.98]) of knee valgus angles. The Pearson’s correlation coefficients of OpenPose-MA and Human-MA relative to that of 3D-MA were 0.97 and 0.98, respectively. This study demonstrated that OpenPose-MA achieved satisfactory reproducibility, accuracy and exhibited waveform similarity comparable to 3D-MA, similar to Human-MA. Both OpenPose-MA and Human-MA showed a strong correlation with 3D-MA in terms of knee valgus angle excursion.
  • Improved responsiveness for JKOOS+ compared to KOOS in Japanese patients undergoing total knee arthroplasty.
    Stephen Lyman, Go Omori, Norimasa Nakamura, Toshiaki Takahashi, Harukazu Tohyama, Naoshi Fukui, Hiroshi Ikeda, Takahisa Sasho, Tomoyuki Saito, Yasuhisa Hayashi, Masataka Deie
    Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 29, 5, 1255, 1258, Sep. 2024, [Peer-reviewed], [Domestic magazines]
    English, Scientific journal, BACKGROUND: Existing knee related patient reported outcome measurements (PROMs) have overwhelmingly been developed and validated in western chair-based societies, suggesting a potential for a western bias in PROMs evaluation of patients with knee conditions. We, therefore, endeavor to evaluate the responsiveness of the previously developed culturally relevant Japanese version of the knee injury and osteoarthritis outcome score (JKOOS+). METHODS: We enrolled 114 patients scheduled for total knee arthroplasty (TKA) across 8 knee clinics in Japan. Patients completed the Oxford Knee Score (OKS) and JKOOS + both at the time of enrollment and again 1-year post-TKA. Responsiveness was evaluated using effect size and standardized response mean (SRM). An effect size or SRM >0.8 is considered adequately responsive. We further tested the difference in responsiveness between the original Japanese language KOOS activities of daily living (ADL) domain and the novel Japanese ADL (JADL) domain using the modified Jacknife test. RESULTS: All domains were adequately responsive with the exception of the KOOS sports and recreation domain, which has previously been ignored by TKA researchers due to its lack of applicability to elderly patients undergoing TKA. The JADL domain outperformed the ADL domain in both effect size (1.51 v. 1.45) and SRM (1.67 v. 1.57) (p < 0.001). The novel Knee Flexion (KF) domain was adequately responsive, though less responsive than other domains except sports and recreation (p < 0.01 v. all other PROMs domains). CONCLUSIONS: The JKOOS+ JADL domain is significantly more responsive than the Europe-developed ADL domain to TKA in Japanese knee patients suffering from knee osteoarthritis (OA). The KF domain, unique to the JKOOS+ and intended to assess difficulty with knee flexion, is adequately responsive to TKA in Japanese patients suffering from OA.
  • Japanese Orthopaedic Association (JOA) clinical practice guidelines on the management of Osteoarthritis of the knee - Secondary publication.
    Yuji Uchio, Muneaki Ishijima, Masahiko Ikeuchi, Shiro Ikegawa, Yasuyuki Ishibashi, Go Omori, Naoto Shiba, Ryohei Takeuchi, Sakae Tanaka, Hiroshi Tsumura, Masataka Deie, Harukazu Tohyama, Noriko Yoshimura, Yasuharu Nakashima
    Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 09 Aug. 2024, [Peer-reviewed], [Domestic magazines]
    English, Scientific journal
  • Effects of Different Amounts of Dynamic Stretching on Musculotendinous Extensibility and Muscle Strength
    Minori Tanaka, Yuta Koshino, Kensuke Oba, Fuma Sentoku, Miho Komatsuzaki, Naoto Kyotani, Tomoya Ishida, Satoshi Kasahara, Harukazu Tohyama, Mina Samukawa
    Applied Sciences, 14, 15, 6745, 6745, MDPI AG, 02 Aug. 2024, [Peer-reviewed]
    Scientific journal, Dynamic stretching (DS) is performed as a warm-up to improve the range of motion and athletic performance. However, the effect of different amounts of DS on muscle performance remains unclear. This study investigated the effects of DS repetitions with one or four sets of 30 s on musculotendinous extensibility and muscle strength. Fourteen healthy men (23.6 ± 1.5 years) underwent DS to ankle plantar flexors for one set (fifteen repetitions) or four sets after warm-up. The maximal ankle dorsiflexion angle, musculotendinous stiffness (MTS), passive torque, peak plantarflexion torque during maximal isometric contraction, and muscle temperature were measured before and after stretching. A significant effect of time was observed on the maximal ankle dorsiflexion angle, MTS, passive torque, and muscle temperature (p < 0.001). However, no interactions or effects between the conditions were observed. After DS, the maximal ankle dorsiflexion angle and muscle temperature significantly increased (p < 0.01), while the MTS and passive torque significantly decreased (p < 0.01). The maximal muscle strength showed no significant effects or interactions (p = 0.198−0.439). These results indicated that one and four sets of DS effectively increased musculotendinous extensibility. Thus, one set of DS may have similar effects as a warm-up before four sets of DS.
  • Abductor hallucis muscle activity during short foot exercise in combination with static and dynamic functional tasks
    Yuta Koshino, Mana Kimura, Mina Samukawa, Satoshi Kasahara, Tomoya Ishida, Harukazu Tohyama
    Gait & Posture, 113, 498, 503, Elsevier BV, Aug. 2024, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, BACKGROUND: Short foot exercise (SFE) can be combined with dynamic functional tasks such as squats; however, it is unclear whether this combination increases intrinsic foot muscle activity. RESEARCH QUESTION: This study aimed to investigate and compare the abductor hallucis muscle (AbdH) activity during SFE in static and dynamic functional tasks. METHODS: The AbdH electromyography data of 17 healthy participants with and without SFE were analyzed during static tasks (sitting, double-leg standing, and single-leg standing) and dynamic tasks (double-leg squat, single-leg squat, split squat, and heel-raise). The static tasks were performed with SFE for 5 seconds, and the dynamic tasks were performed while performing SFE. AbdH activity with or without SFE during the task was compared using the Friedman and Wilcoxon signed-rank tests. RESULTS: AbdH activity was significantly greater in conditions with SFE than in those without SFE for all tasks (P < 0.01) except for heel-raise (P = 0.163). AbdH activity during SFE in single-leg standing was significantly higher than that in sitting, double-leg standing, and double-leg squats (P < 0.05). AbdH activity during SFE in the single-leg squat was also significantly greater than that in the sitting position (P = 0.024). No significant differences were found in any other between-task comparisons of AbdH activity during SFE. AbdH activity during tasks without SFE revealed significantly lower levels for sitting and double-leg standing compared to single-leg squat, split squat, and heel-raise (P < 0.001). Additionally, the activity in double-leg squat was significantly lower than in both single-leg squat and heel-raise (P < 0.05). SIGNIFICANCE: Combining dynamic tasks, except for the heel-raise task, with SFE can increase AbdH activity more than dynamic tasks without SFE. However, clinicians should note that combining dynamic tasks with the SFE may not increase AbdH activity compared to combining static tasks with the SFE.
  • Relationship among the COM Motion, the Lower Extremity and the Trunk during the Squat.
    Satoshi Kasahara, Tomoya Ishida, Jiang Linjing, Ami Chiba, Mina Samukawa, Harukazu Tohyama
    Journal of human kinetics, 93, 29, 39, Jul. 2024, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, Squatting is a common motion in activities of daily living and is frequently used in training programs. Squatting requires a shift of the body in both vertical and anterior-posterior directions. Postural control during squatting is considered a mixed strategy; however, details and roles of the trunk and lower limb joints are unclear. The purpose of this study was to investigate the relationship among the kinematics of the lower limb, the trunk and the center of mass (COM) descent during squatting. Twenty-six healthy young adults performed repeated parallel squats. Lower limb joint and trunk angles and the COM were analyzed using a 3D motion analysis system. We evaluated the relationship between the kinematics and the squat depth by performing correlation analysis and multiple linear regression analysis. The ankle was the first to reach its maximum angle, and the remaining joints reached their maximum angles at the maximum squat depth. The knee joint motion and the squat depth were significantly correlated and there was a correlation between the hip and the ankle joint motion and the anteroposterior displacement of the COM during squatting. Multivariate linear regression analysis indicated that squat depth was predicted by both the knee and ankle motion and that anteroposterior displacement of the COM was predicted by the hip, ankle, and knee joint motion. The knees contributed to the vertical COM motion during squatting, while the hips contributed to the COM motion in the anteroposterior direction. On the other hand, the ankles contributed to COM motions in both the vertical and anteroposterior directions during squatting.
  • Validity of muscle activation estimated with predicted ground reaction force in inverse dynamics based musculoskeletal simulation during gait.
    Ryo Ueno, Yasuaki Tsuyuki, Harukazu Tohyama
    Journal of biomechanics, 168, 112118, 112118, May 2024, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, The inverse dynamics based musculoskeletal simulation needs ground reaction forces (GRF) as an external force input. GRF can be predicted from kinematic data. However, the validity of estimated muscle activation using the predicted GRF has remained unclear. Therefore, the purpose of this study was to determine the validity of estimated muscle activation with predicted GRF in the inverse dynamics based musculoskeletal simulation. To perform musculoskeletal simulations, an open-source motion capture dataset that contains gait data from 50 healthy subjects was used. CusToM was used for the musculoskeletal simulations. Two sets of inverse dynamics and static optimization were performed, one used predicted GRF (PRED) and another used experimentally measured GRF (EXP). Pearson's correlation was calculated to evaluate the similarity between EMG and estimated muscle activations for both PRED and EXP. To compare PRED and EXP, paired t-tests were used to compare the trial-wise muscle activation similarity and residuals. Relationships between joint moments and residuals were also tested. The overall muscle activation similarity was comparable in PRED (R = 0.477) and EXP (R = 0.475). The residuals were 2-4 times higher in EXP compared to PRED (P < 0.001). The hip flexion-extension moment was correlated to sagittal plane residual moment (R = 0.467). The muscle activations estimated using predicted GRF were comparable to that with measured GRF in the inverse dynamics based musculoskeletal simulation. Prediction of GRF helps to perform musculoskeletal simulations where the force plates are not available.
  • Development of a Conversion Table Linking Functional Independence Measure Scores to International Classification of Functioning, Disability, and Health Qualifiers: Insights from a Survey of Healthcare Professionals.
    Shu Umemori, Mao Ogawa, Shin Yamada, Masayo Komatsu, Emiko Oikawa, Yasuyo Okamoto, Masaki Katoh, Tomohide Shirasaka, Kagari Abiko, Shigehiro Moriizumi, Yuichiro Matsuo, Harukazu Tohyama, Masahiko Mukaino
    Healthcare (Basel, Switzerland), 12, 8, 15 Apr. 2024, [Peer-reviewed], [International Magazine]
    English, Scientific journal, In clinical practice, patient assessments rely on established scales. Integrating data from these scales into the International Classification of Functioning, Disability, and Health (ICF) framework has been suggested; however, a standardized approach is lacking. Herein, we tested a new approach to develop a conversion table translating clinical scale scores into ICF qualifiers based on a clinician survey. The survey queried rehabilitation professionals about which functional independence measure (FIM) item scores (1-7) corresponded to the ICF qualifiers (0-4). A total of 458 rehabilitation professionals participated. The survey findings indicated a general consensus on the equivalence of FIM scores with ICF qualifiers. The median value for each item remained consistent across all item groups. Specifically, FIM 1 had a median value of 4; FIM 2 and 3 both had median values of 3; FIM 4 and 5 both had median values of 2; FIM 6 had a median value of 1; and FIM 7 had a median value of 0. Despite limitations due to the irreconcilable differences between the frameworks of existing scales and the ICF, these results underline the ICF's potential to serve as a central hub for integrating clinical data from various scales.
  • The relationship between joint kinematic patterns during single-leg drop landing and perceived instability in individuals with chronic ankle instability.
    Kentaro Watanabe, Yuta Koshino, Kosumi Nakagawa, Tomoya Ishida, Satoshi Kasahara, Mina Samukawa, Harukazu Tohyama
    Clinical biomechanics (Bristol, Avon), 114, 106237, 106237, 05 Apr. 2024, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, BACKGROUND: Perceived instability is a primary symptom among individuals with chronic ankle instability. However, the relationship between joint kinematics during landing remains unclear. Therefore, we investigated the relationships between landing kinematics and perceived instability in individuals with chronic ankle instability. METHODS: In 32 individuals with chronic ankle instability, we recorded ankle, knee, and hip joint angles during a single-leg drop landing. Joint angle waveforms during 200 ms before and after initial contact were summarized into single values using two methods: peak joint angles and principal component scores via principal component analysis. Using Spearman's rank correlation coefficient (ρ), we examined the relationships of peak joint angles and principal component scores with the Cumberland Ankle Instability Tool score, with a lower score indicating a greater perceived instability (α = 0.05). FINDINGS: The second principal component scores of ankle angle in the horizontal and sagittal planes significantly correlated with the Cumberland Ankle Instability Tool score (Horizontal: ρ = 0.507, P = 0.003; Sagittal: ρ = -0.359, P = 0.044). These scores indicated the differences in the magnitude of angles before and after landing. Significant correlations indicated a greater perceived instability correlated with smaller internal rotation and plantarflexion before landing and smaller external rotation and dorsiflexion after landing. In contrast, no peak joint angles correlated with the Cumberland Ankle Instability Tool score (P > 0.05). INTERPRETATION: In individuals with chronic ankle instability, ankle movements during landing associated with perceived instability may be a protective strategy before landing and potentially cause ankle instability after landing.
  • The Effects of Active Stretching Exercise on Mood and Autonomic Modulation in Middle-Aged Women
    Miho Komatsuzaki, Yuta Koshino, Tomoya Ishida, Satoshi Kasahara, Fiorella Apolo Soria, Yasuhiko Ebina, Harukazu Tohyama, Mina Samukawa
    Women's Health Reports, 5, 1, 680, 688, Mary Ann Liebert Inc, 01 Apr. 2024, [Peer-reviewed]
    Scientific journal
  • Relationship between onset of trunk muscle activities and pelvic kinematics in individuals with and without chronic low back pain.
    Akimi Nakata, Satoshi Osuka, Tomoya Ishida, Yuki Saito, Yuta Koshino, Mina Samukawa, Satoshi Kasahara, Harukazu Tohyama
    Journal of back and musculoskeletal rehabilitation, 37, 5, 1391, 1400, 19 Mar. 2024, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, BACKGROUND: Lumbopelvic movement patterns during prone hip extension has been proposed as a clinical screening method for trunk muscle dysfunction in patients with chronic low back pain (CLBP). However, correlations between trunk muscle onset and pelvic kinematics have not been investigated. OBJECTIVE: To examine the correlation between trunk muscle onset and pelvic kinematics during prone hip extension in participants with CLBP. METHODS: Fifteen patients with CLBP and 15 healthy individuals participated. We evaluated the muscle activities of the lumbar multifidus, the longissimus, and the semitendinosus via electromyogram and the displacement angles of the pelvic tilt, oblique and rotation. RESULTS: The onset of the multifidus at the ipsilateral side of hip extension was significantly delayed in the patients with CLBP compared to the control group (P< 0.001). The onset of the ipsilateral multifidus in the control group was significantly correlated with increased anterior pelvic tilt angle (P= 0.019, r= 0.597), whereas no significant correlation was observed in the CLBP group (P= 0.810, r=-0.068). CONCLUSION: The results suggest that pelvic kinematics during prone hip extension does not predict the delayed trunk muscle onset in patients with CLBP.
  • Trunk Muscle Activity and Ratio of Local Muscle to Global Muscle Activity during Supine Bridge Exercises under Unstable Conditions in Young Participants with and without Chronic Low Back Pain
    Akimi Nakata, Satoshi Osuka, Tomoya Ishida, Yuki Saito, Mina Samukawa, Satoshi Kasahara, Yuta Koshino, Naoki Oikawa, Harukazu Tohyama
    Healthcare, 12, 5, 514, 21 Feb. 2024, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, Core exercises on an unstable surface increase trunk muscle activity, especially for local muscle groups. Therefore, there is a possibility that exercises on an unstable surface would be effective in the rehabilitation of non-specific chronic low back pain (NSCLBP). The present study assessed trunk muscle activities during bridge exercise on the floor and two kinds of unstable surfaces, i.e., a balance ball and the BOSU, for individuals with and without NSCLBP. This study enrolled 17 and 18 young participants with and without NSCLBP, respectively. In the balance ball condition, both groups showed a significant increase in erector spinae activity compared to the floor condition, and the increase in activity was significantly greater in the NSCLBP group than in the control group (p = 0.038). On the other hand, neither group showed significant changes in trunk muscle activities in the BOSU condition compared to those in the floor condition. The control group showed a significant increase in internal oblique/transversus abdominis activity under the balance ball condition (p = 0.020), whereas there were no significant changes in these muscle activities between the balance ball and floor conditions in the NSCLBP group. The present study showed that participants with NSCLBP significantly increased muscle activity of the erector spinae, one of the global back muscles, on the balance ball in spite of small effects on muscle activity of the internal oblique/transversus abdominis, which is one of the local abdominal muscles. Therefore, attention should be paid to the application of bridge exercises on the balance ball for individuals with NSCLBP.
  • Effect of suspensory strategy on balance recovery after lateral perturbation.
    Linjing Jiang, Satoshi Kasahara, Tomoya Ishida, Yuta Koshino, Ami Chiba, Yuting Wei, Mina Samukawa, Harukazu Tohyama
    Human movement science, 94, 103184, 103184, 07 Feb. 2024, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, Postural stability is essential for performing daily activities and preventing falls, whereby suspensory strategy with knee flexion may play a role in postural control. However, the contribution of the suspensory strategy for postural control during sudden lateral perturbation remains unclear. We aimed to determine how suspensory strategy contributed to postural adjustment during sudden perturbation in the lateral direction and what knee flexion setting maximized its effect. Eighteen healthy young adults (10 male and 8 female) participated in this study. Kinematic data during lateral perturbation at three velocities (7, 15, and 20 cm/s) were collected under three knee flexion angle conditions (0°, 15°, and 65°) using motion capture technology. Postural adjustments to the external perturbation were assessed by four parameters related to the temporal aspects of the center of mass (COM): reaction time, peak displacement/time and reversal time, and minimum value of the margin of stability (minimum-MOS). Our results showed that the COM height before the perturbation significantly lowered with increasing knee flexion angle. The COM reaction times for low and mid perturbation velocities were delayed at 65° of knee flexion compared to 0° and 15°, and the COM reversal times were significantly shorter at 65° of knee flexion than at 0° and 15° across all perturbation velocities. The minimum-MOS at the high-velocity of perturbation was significantly smaller at 65° of knee flexion than at 0° and 15°. In conclusion, the adoption of a suspensory strategy with slight knee flexion induced enhanced stability during sudden external and lateral perturbations. However, excessive knee flexion induced instability.
  • Estimation of Vertical Ground Reaction Force during Single-leg Landing Using Two-dimensional Video Images and Pose Estimation Artificial Intelligence
    Tomoya ISHIDA, Takumi INO, Yoshiki YAMAKAWA, Naofumi WADA, Yuta KOSHINO, Mina SAMUKAWA, Satoshi KASAHARA, Harukazu TOHYAMA
    Physical Therapy Research, 27, 1, 35, 41, Japanese Physical Therapy Association, 2024, [Peer-reviewed], [Last author], [Domestic magazines]
    English, Scientific journal, OBJECTIVE: Assessment of the vertical ground reaction force (VGRF) during landing tasks is crucial for physical therapy in sports. The purpose of this study was to determine whether the VGRF during a single-leg landing can be estimated from a two-dimensional (2D) video image and pose estimation artificial intelligence (AI). METHODS: Eighteen healthy male participants (age: 23.0 ± 1.6 years) performed a single-leg landing task from a 30-cm height. The VGRF was measured using a force plate and estimated using center of mass (COM) position data from a 2D video image with pose estimation AI (2D-AI) and three-dimensional optical motion capture (3D-Mocap). The measured and estimated peak VGRFs were compared using a paired t-test and Pearson's correlation coefficient. The absolute errors of the peak VGRF were also compared between the two estimations. RESULTS: No significant difference in the peak VGRF was found between the force plate measured VGRF and the 2D-AI or 3D-Mocap estimated VGRF (force plate: 3.37 ± 0.42 body weight [BW], 2D-AI: 3.32 ± 0.42 BW, 3D-Mocap: 3.50 ± 0.42 BW). There was no significant difference in the absolute error of the peak VGRF between the 2D-AI and 3D-Mocap estimations (2D-AI: 0.20 ± 0.16 BW, 3D-Mocap: 0.13 ± 0.09 BW, P = 0.163). The measured peak VGRF was significantly correlated with the estimated peak by 2D-AI (R = 0.835, P <0.001). CONCLUSION: The results of this study indicate that peak VGRF estimation using 2D video images and pose estimation AI is useful for the clinical assessment of single-leg landing.
  • Fear-Avoidance Beliefs Associated with Non-Specific Chronic Low Back Pain in College Athletes
    Satoshi Osuka, Yuta Koshino, Kentaro Watanabe, Yoshiaki Kataoka, Harukazu Tohyama
    Journal of Pain Research, Volume 17, 285, 292, Informa UK Limited, Jan. 2024, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, PURPOSE: This study aimed to determine the psychosocial factors associated with non-specific chronic low back pain (NS-CLBP) among college athletes. MATERIAL AND METHODS: A cross-sectional study was performed at one university. A non-anonymous, self-administered online questionnaire was collected from each athlete. Participants with a history of orthopaedic spine disease or surgery were excluded. Online responses from 368 college athletes belonging to 18 clubs were collected, among which 263 were included in the analysis. In the 263 responses, 41 individuals were identified as having NS-CLBP. Multivariate logistic regression analyses were performed to determine factors associated with presence of NS-CLBP. Independent variables included the Fear-Avoidance Beliefs Questionnaire physical activity subscale (FABQ-PA) score, Tampa Scale for Kinesiophobia-11 (TSK-11) score, Roland-Morris Disability Questionnaire (RDQ) score, and body mass index (BMI). Additionally, the Mann-Whitney U-test was utilized to compare FABQ-PA, TSK-11, RDQ scores, and BMI between the NS-CLBP and non-NS-CLBP groups. RESULTS: The FABQ-PA (odd ratio = 1.096, P = 0.003) was significantly associated with NS-CLBP. No significant association was observed between NS-CLBP and TSK-11 (P = 0.776), RDQ (P = 0.074), and BMI (P = 0.296). The scores for FABQ-PA, TSK-11, RDQ, and BMI in the group with NS-CLBP were found to be significantly higher compared to the group without NS-CLBP (P < 0.001, P = 0.034, P < 0.001, and P = 0.022, respectively). CONCLUSION: The present study revealed a significant relationship between higher FABQ-PA scores and NS-CLBP among college athletes. Conversely, TSK-11 and BMI values showed no significant association with NS-CLBP presence. The findings suggest that addressing fear-avoidance beliefs may be crucial in managing NS-CLBP among college athletes.
  • Sex-related differences in stretch-induced musculotendinous stiffness changes
    Miho Komatsuzaki, Mina Samukawa, Kensuke Oba, Yuta Koshino, Tomoya Ishida, Satoshi Kasahara, Harukazu Tohyama
    Sport Sciences for Health, Springer Science and Business Media LLC, 16 Dec. 2023, [Peer-reviewed], [Last author]
    Scientific journal
  • Validity of AI-Based Gait Analysis for Simultaneous Measurement of Bilateral Lower Limb Kinematics Using a Single Video Camera
    Takumi Ino, Mina Samukawa, Tomoya Ishida, Naofumi Wada, Yuta Koshino, Satoshi Kasahara, Harukazu Tohyama
    Sensors, 23, 24, 9799, 9799, MDPI AG, 13 Dec. 2023, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, Accuracy validation of gait analysis using pose estimation with artificial intelligence (AI) remains inadequate, particularly in objective assessments of absolute error and similarity of waveform patterns. This study aimed to clarify objective measures for absolute error and waveform pattern similarity in gait analysis using pose estimation AI (OpenPose). Additionally, we investigated the feasibility of simultaneous measuring both lower limbs using a single camera from one side. We compared motion analysis data from pose estimation AI using video footage that was synchronized with a three-dimensional motion analysis device. The comparisons involved mean absolute error (MAE) and the coefficient of multiple correlation (CMC) to compare the waveform pattern similarity. The MAE ranged from 2.3 to 3.1° on the camera side and from 3.1 to 4.1° on the opposite side, with slightly higher accuracy on the camera side. Moreover, the CMC ranged from 0.936 to 0.994 on the camera side and from 0.890 to 0.988 on the opposite side, indicating a “very good to excellent” waveform similarity. Gait analysis using a single camera revealed that the precision on both sides was sufficiently robust for clinical evaluation, while measurement accuracy was slightly superior on the camera side.
  • Arthroscopic Hip Capsular Repair Improves Patient-Reported Outcome Measures and Is Associated With a Decreased Risk of Revision Surgery and Conversion to Total Hip Arthroplasty.
    Soshi Uchida, Kazuha Kizaki, Maharaj S Arjuna, Yoichi Murata, Yoshiharu Shimozono, Kazutomo Miura, Koichi Nakagawa, Atsuo Nakamae, Toshiyasu Nakamura, Tadahiro Sakai, Kazuhiko Kikugawa, Tatsuo Mae, Eiichi Tsuda, Harukazu Tohyama
    Arthroscopy, sports medicine, and rehabilitation, 5, 6, 100800, 100800, Dec. 2023, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, PURPOSE: To perform a systematic review to assess the effect of capsular repair compared with nonrepair on patient-reported outcome measures (PROMs) and conversion to total hip arthroplasty (THA) after hip arthroscopy in patients with femoroacetabular impingement syndrome. METHODS: We initially searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, and PubMed databases, as well as ongoing clinical trials (https://clinicaltrials.gov), on December 15, 2022. The eligibility criteria were randomized controlled trials (Level Ⅰ) and prospective comparative studies (Level II) of patients who underwent capsular repair and nonrepair via hip arthroscopy with a minimum follow-up period of 2 years. We registered this protocol a priori on PROSPERO (identification No. CRD42021239306). We assessed the risk of bias using the Methodological Index for Non-randomized Studies (MINORS) appraisal tool. RESULTS: This review included 5 studies with a total of 639 patients (270 with capsular repair [average age, 35.4 years; 41% female patients] and 369 with nonrepair [average age, 37.3 years; 38% female patients]). In the included studies, surgical procedures consisting of labral repair and pincer or cam osteoplasty were performed via hip arthroscopy. The modified Harris Hip Score was measured in all the included studies, and the standardized mean difference in PROMs for capsular repair versus nonrepair in the included studies was 0.42 (95% confidence interval [CI], 0.20 to 0.63). A sensitivity analysis of randomized controlled trials achieved consistent results (standardized mean difference in PROMs, 0.31; 95% CI, 0.02 to 0.60). Capsular repair was not associated with a reduction in revision surgery (risk difference, -0.02; 95% CI, -0.06 to 0.03; 26 of 270 patients with capsular repair vs 42 of 369 with nonrepair) but was associated with a reduction in conversion to THA (risk difference, -0.05; 95% CI -0.09 to -0.01; 12 of 270 patients with capsular repair vs 38 of 369 with nonrepair). The average Methodological Index for Non-randomized Studies (MINORS) score in the included studies was 20. CONCLUSIONS: Patients who undergo capsular repair in conjunction with other arthroscopic hip preservation techniques have better PROMs and a lower incidence of THA conversion. LEVEL OF EVIDENCE: Level II, systematic review of Level I and II investigations.
  • Change in sensory integration and regularity of postural sway with the suspensory strategy during static standing balance
    Linjing Jiang, Satoshi Kasahara, Tomoya Ishida, Yuta Koshino, Ami Chiba, Kazumasa Yoshimi, Yuting Wei, Mina Samukawa, Harukazu Tohyama
    Frontiers in Neurology, 14, 1290986, 1290986, Frontiers Media SA, 31 Oct. 2023, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, Background and aim

    The suspensory strategy, a method for controlling postural balance in the vertical direction of the center of mass (COM), is considered by the elderly as a means of balance control. The vertical COM control might alter the sensory integration and regularity of postural sway, which in turn impacts balance. However, to date, this was not confirmed. Thus, this study aimed at investigating the influence of the suspensory strategy achieved through knee flexion on the static standing balance.

    Methods

    Nineteen participants were monitored at knee flexion angles of 0°, 15°, and 65°. Time-frequency analysis and sample entropy were employed to analyze the COM data. Time-frequency analysis was utilized to assess the energy content across various frequency bands and corresponding percentage of energy within each frequency band. The outcomes of time-frequency are hypothesized to reflect the balance-related sensory input and sensory weights. Sample entropy was applied to evaluate the regularity of the COM displacement patterns.

    Results

    Knee flexion led to a decreased COM height. The highest energy content was observed at 65° knee flexion, in contrast with the lowest energy observed at 0° in both the anterior–posterior (AP) and medial-lateral (ML) directions. Additionally, the ultra-low-frequency band was more pronounced at 65° than that at 0° or 15° in the ML direction. Furthermore, the COM amplitudes were notably higher at 65° than those at 0° and 15° in the AP and ML directions, respectively. The sample entropy values were lower at 65° and 15° than those at 0° in the ML direction, with the lowest value observed at 65° in the vertical direction.

    Conclusion

    The suspensory strategy could enhance the sensory input and cause sensory reweighting, culminating in a more regular balance control. Such suspensory strategy-induced postural control modifications may potentially provide balance benefits for people with declining balance-related sensory, central processing, and musculoskeletal system functions.
  • Hip and knee kinematics, center of pressure position, and ground reaction force are associated with Achilles tendon force during jump landing.
    Yuta Koshino, Tomoya Ishida, Shohei Taniguchi, Mina Samukawa, Satoshi Kasahara, Harukazu Tohyama
    Scandinavian journal of medicine & science in sports, 34, 1, e14510, 03 Oct. 2023, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, PURPOSE: Jump-landing exercises are often performed during the rehabilitation of Achilles tendon (AT) injuries. However, the factors that affect the AT force (ATF) during landing are unclear. This study aimed to determine the kinematics and ground reaction force (GRF) variables associated with the peak ATF during a drop vertical jump (DVJ). METHODS: The landing phase of DVJ was evaluated in 101 healthy participants (46 males, age: 21.2 ± 1.4 years old) using a three-dimensional motion analysis system with two force plates. ATF was estimated from the ankle flexion angle and moment. Univariate and multivariate regression analyses were performed with the peak ATF as the dependent variable. The vertical GRF (VGRF), center of pressure (COP), forward trunk leaning, hip/knee/ankle joint angles at peak ATF, and sex were used as independent variables. RESULTS: In the univariate regression analysis, larger VGRF (β = 0.813), more anterior COP position (β = 0.214), smaller knee flexion (β = -0.251) and adduction (β = -0.252), smaller hip flexion (β = -0.407), smaller forward trunk lean (β = -0.492), and male sex (β = -0.282) were significantly associated with a larger peak ATF. Multivariate analysis revealed that larger VGRF (β = 1.018), more anterior COP position (β = 0.320), a larger knee (β = 0.442), and smaller hip flexion (β = -0.205) were associated with the larger peak ATF. CONCLUSIONS: The VGRF, COP position, and knee and hip flexion were independently associated with ATF. Modifying these factors may be useful in managing tendon loading during jump-landing exercises.
  • Association of Psychological Readiness to Return to Sports With Subjective Level of Return at 12 Months After ACL Reconstruction.
    Makoto Suzuki, Tomoya Ishida, Hisashi Matsumoto, Satoru Kaneko, Chiharu Inoue, Yoshimitsu Aoki, Harukazu Tohyama, Mina Samukawa
    Orthopaedic journal of sports medicine, 11, 9, 23259671231195030, 23259671231195030, Sep. 2023, [Peer-reviewed], [International Magazine]
    English, Scientific journal, BACKGROUND: Return-to-sports (RTS) rates after anterior cruciate ligament (ACL) reconstruction (ACLR) differ according to the level at which patients return. It is unclear whether the level of RTS is affected by psychological readiness to return. PURPOSE: To examine the association between psychological readiness to RTS and subjective RTS level 12 months after ACLR. STUDY DESIGN: Case-control study; Level of evidence, 3. METHODS: A total of 47 patients who underwent unilateral primary ACLR surgery were enrolled. Assessments at 6 and 12 months postoperatively consisted of knee strength testing (isokinetic quadriceps and hamstring strength), the International Knee Documentation Committee Subjective Knee Evaluation Form (IKDC-SKF), and the Anterior Cruciate Ligament-Return to Sport after Injury (ACL-RSI) scale to measure psychological readiness to RTS. Patients were assigned to 1 of 3 subgroups based on their subjective assessment of RTS level at 12 months postoperatively: RTS at or above preinjury level (RTS≥Pre; n = 19), RTS below preinjury level (RTS
  • Factors associated with persistent pain in college athletes with a history of lateral ankle sprain.
    Yuta Koshino, Kentaro Watanabe, Moeko Akimoto, Tomoya Ishida, Mina Samukawa, Satoshi Kasahara, Harukazu Tohyama
    Physical therapy in sport : official journal of the Association of Chartered Physiotherapists in Sports Medicine, 64, 27, 31, 30 Aug. 2023, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, OBJECTIVES: To determine the factors associated with and prevalence of persistent pain in college athletes with chronic ankle instability (CAI) and with previous lateral ankle sprain (LAS) without CAI. DESIGN: Cross-Sectional Study. SETTING: Online survey at one university. PARTICIPANTS: Of the 385 respondents surveyed online, 140 were identified as having experienced at least one LAS (CAI group: 69, coper group: 24, LAS group not classified as either: 47). MAIN OUTCOME MEASURES: Factors associated with the presence of pain during activities of daily living (ADL) and sports were identified using multivariate logistic regression analyses. Independent variables were demographics, injury characteristics, the Identification of Functional Ankle Instability (IdFAI) score, the Foot and Ankle Ability Measure Sports (FAAM-Sports) and ADL subscales, and the Tampa Scale for Kinesiophobia-11 score. RESULTS: The prevalence of pain during ADL and sports in the three groups was 16.7%-42.0% and 33.3%-56.5%, respectively. FAAM-Sports and IdFAI score were significantly associated with pain during ADL and sports in the CAI group (odd ratio: 0.923 and 1.145), respectively. No significant pain-related factors were found in the coper and LAS groups. CONCLUSIONS: Lower self-reported function and greater perceived ankle instability may be important factors in pain management in athletes with CAI.
  • Effect of toe-out gait modification on patellofemoral joint loading.
    Kento Sabashi, Takeshi Chiba, Masanori Yamanaka, Harukazu Tohyama
    Gait & posture, 104, 135, 139, Jul. 2023, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, BACKGROUND: Toe-out gait has been proposed as a conservative treatment to reduce medial tibiofemoral joint loading. However, patellofemoral joint loading during toe-out gait is not yet understood. RESEARCH QUESTION: Does the toe-out gait modification affect patellofemoral joint loading? METHODS: Sixteen healthy adults were enrolled in this study. The natural gait and toe-out gait were measured using a three-dimensional motion analysis and a force plate. The knee flexion angle and external knee flexion moment during the stance phase were calculated. Thus, dynamic knee joint stiffness, a proxy of patellofemoral joint loading, was defined as a linear regression of the knee flexion moment and knee flexion angle during the early stance. Additionally, the peak patellofemoral compressive force during the early stance was calculated using a musculoskeletal simulation. A paired t-test was used to compare these biomechanical parameters during the natural gait and toe-out gait. RESULTS: The toe-out gait significantly increased the peak patellofemoral compressive force (mean difference = 0.37 BW, P = 0.017) and dynamic knee joint stiffness (mean difference = 0.07%BW*Ht/°, P = 0.001). The 1st peak of the knee flexion moment also significantly increased in the toe-out gait (mean difference = 1.01%BW*Ht, P = 0.003); however, the knee flexion angle did not change significantly (initial contact: mean difference = 1.7°, P = 0.078; peak: mean difference = 1.3°, P = 0.224). SIGNIFICANCE: Toe-out gait increased the patellofemoral compressive force and dynamic knee joint stiffness because of increasing knee flexion moment, but not the knee flexion angle. When the toe-out gait is adapted, clinicians should pay attention to an increase in the patellofemoral joint loading.
  • Interlimb Asymmetry in Knee Extension Moment During Double-Leg Squatting Is Associated With Persistent Quadriceps Weakness After ACL Reconstruction.
    Tomoya Ishida, Mina Samukawa, Yuta Koshino, Takumi Ino, Satoshi Kasahara, Harukazu Tohyama
    Orthopaedic journal of sports medicine, 11, 6, 23259671231182105, 23259671231182105, Jun. 2023, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, BACKGROUND: Although double-leg squatting is less dynamic and places less demand on the quadriceps compared with landing tasks, the relationship between double-leg squatting biomechanics and persistent quadriceps weakness after anterior cruciate ligament reconstruction (ACLR) is unknown. PURPOSE: To clarify the relationships between asymmetries in quadriceps strength and lower limb biomechanics during double-leg squatting >1 year after ACLR. STUDY DESIGN: Controlled laboratory study. METHODS: A total of 26 participants (5.5 ± 3.8 years after ACLR) were enrolled. The limb symmetry index (LSI) of isokinetic quadriceps strength was used to divide participants into the high-quadriceps (HQ) group (LSI ≥90%; n = 18) and the low-quadriceps (LQ) group (LSI <90%; n = 8). The knee, hip, and ankle extension moment (relative to body weight and support moment [sum of knee, hip, and ankle moments]) and vertical ground-reaction force during double-leg squatting were analyzed using 3-dimensional motion analysis. The association of quadriceps strength and biomechanical variables was tested using 2-way analysis of variance and univariate regression analysis. RESULTS: A significant group-by-limb interaction was found for the peak knee extension moment and the ratios of knee and hip extension moment to support moment (P < .001, P = .015 and P < .001, respectively). The LQ group showed a significantly smaller peak knee extension moment and knee to support moment ratio but a larger hip to support moment ratio in the involved limb than in the uninvolved limb (95% CIs: knee extension moment, -0.273 to -0.088 N·m/kg; knee to support moment ratio, -10.7% to -2.2%; hip to support moment ratio, 3.2% to 8.5%). No interlimb difference was found for the HQ group. The LSI of quadriceps strength was significantly associated with the LSI of peak knee extension moment (R2 = 0.183), knee to support moment ratio (R2 = 0.256), and hip to support moment ratio (R2 = 0.233). The mean maximum isokinetic quadriceps strength and peak knee extension moment during squatting on the involved limb of the LQ group were 2.40 ± 0.39 and 0.90 ± 0.16 N·m/kg, respectively. CONCLUSION: Asymmetrical biomechanics during double-leg squatting was associated with persistent quadriceps weakness after ACLR. The LQ group had reduced knee extensor moment on the involved side during squatting despite loading at approximately half the maximum strength. CLINICAL RELEVANCE: Quadriceps strengthening exercises, together with interventions to improve neuromuscular control, may reduce asymmetrical biomechanics during double-leg squatting.
  • Trunk Muscle Activities during Ergometer Rowing in Rowers with and without Low Back Pain.
    Momoko Yamashita, Tomoya Ishida, Satoshi Osuka, Kentaro Watanabe, Mina Samukawa, Satoshi Kasahara, Eiji Kondo, Harukazu Tohyama
    Journal of sports science & medicine, 22, 2, 338, 344, Jun. 2023, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, This study aimed to determine the differences in trunk muscle activity during rowing at maximal effort between rowers with and without low back pain (LBP). Ten rowers with LBP and 12 rowers without LBP were enrolled in this study. All rowers performed a 500-m trial using a rowing ergometer at maximal effort. The amplitudes of the activities of the thoracic erector spinae (TES), lumbar erector spinae (LES), latissimus dorsi (LD), rectus abdominis (RA), and external oblique (EO) muscles were analyzed using a wireless surface electromyography (EMG) system. EMG data at each stroke were converted into 10-time series data by recording averages at every 10% in the 100% stroke cycle and normalized by maximum voluntary isometric contraction in each muscle. Two-way repeated measures analysis of variance was performed. Significant interactions were found in the activities of the TES and LES (P < 0.001 and P = 0.047, respectively). In the post hoc test, the TES activity in the LBP group was significantly higher than that in the control group at the 10% to 20% and 20% to 30% stroke cycles (P = 0.013 and P = 0.007, respectively). The LES activity in the LBP group was significantly higher than that in the control group at the 0% to 10% stroke cycle (P < 0.001). There was a main group effect on the LD activity, with significantly higher activity in the LBP group than in the control group (P = 0.023). There were no significant interactions or main effects in the EO and RA activities between the groups. The present study showed that rowers with LBP compared with those without LBP exhibited significantly higher TES, LES, and LD muscle activities. This indicates that rowers with LBP exhibit excessive back muscle activity during rowing under maximal effort.
  • Subsequent Jumping Increases the Knee and Hip Abduction Moment, Trunk Lateral Tilt, and Trunk Rotation Motion During Single-Leg Landing in Female Individuals.
    Masato Chijimatsu, Tomoya Ishida, Masanori Yamanaka, Shohei Taniguchi, Ryo Ueno, Ryohei Ikuta, Mina Samukawa, Takumi Ino, Satoshi Kasahara, Harukazu Tohyama
    Journal of applied biomechanics, 39, 4, 1, 7, 24 May 2023, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, Single-leg landings with or without subsequent jumping are frequently used to evaluate landing biomechanics. The purpose of this study was to investigate the effects of subsequent jumping on the external knee abduction moment and trunk and hip biomechanics during single-leg landing. Thirty young adult female participants performed a single-leg drop vertical jumping (SDVJ; landing with subsequent jumping) and single-leg drop landing (SDL; landing without subsequent jumping). Trunk, hip, and knee biomechanics were evaluated using a 3-dimensional motion analysis system. The peak knee abduction moment was significantly larger during SDVJ than during SDL (SDVJ 0.08 [0.10] N·m·kg-1·m-1, SDL 0.05 [0.10] N·m·kg-1·m-1, P = .002). The trunk lateral tilt and rotation angles toward the support-leg side and external hip abduction moment were significantly larger during SDVJ than during SDL (P < .05). The difference in the peak hip abduction moment between SDVJ and SDL predicted the difference in the peak knee abduction moment (P = .003, R2 = .252). Landing tasks with subsequent jumping would have advantages for evaluating trunk and hip control as well as knee abduction moment. In particular, evaluating hip abduction moment may be important because of its association with the knee abduction moment.
  • Repetitive Pitching Decreases the Elbow Valgus Stability Provided by the Flexor-Pronator Mass: The Effects of Repetitive Pitching on Elbow Valgus Stability.
    Masaya Nara, Mina Samukawa, Kensuke Oba, Tomoya Ishida, Yoshiya Takahashi, Satoshi Kasahara, Harukazu Tohyama
    Journal of shoulder and elbow surgery, 32, 9, 1819, 1824, 10 May 2023, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, BACKGROUND: Baseball pitching induces a large elbow valgus load, stressing the ulnar collateral ligament. Flexor-pronator mass contraction contributes to valgus stability; however, repetitive baseball pitching may weaken the flexor-pronator mass contractile function. The present study investigated the effects of repetitive baseball pitching on the medial valgus stability measured using ultrasonography. We hypothesized that repetitive pitching would decrease elbow valgus stability. METHODS: This was a controlled laboratory study. Fifteen young male baseball players at the collegiate level (age: 23.0 ± 1.4 years) were enrolled. The medial elbow joint space was measured using ultrasonography (B-mode, 12-MHz linear array transducer) in the following three conditions: at rest (unloaded), under 3 kg valgus load (loaded), and under valgus load with maximal grip contraction to activate flexor-pronator mass (loaded-contracted). All measurements were performed before and after the pitching tasks, which comprised five sets of 20 pitches. Two-way repeated-measures analysis of variance was applied to determine changes in the medial elbow joint space. The post-hoc test with Bonferroni adjustment was applied to assess the changes within the time and condition. RESULTS: The medial elbow joint space was significantly greater under the loaded than the unloaded and loaded-contracted conditions both before- and after- pitching (p < 0.001). In the loaded-contracted condition, the medial elbow joint space significantly increased after repetitive baseball pitching (p < 0.001). CONCLUSIONS: The results of the present study indicated that repetitive baseball pitching reduced the elbow valgus stability. This reduction could be attributed to the decreased flexor-pronator mass contractile function. Insufficient contraction may increase the tensile load on the ulnar collateral ligament with pitching. Flexor-pronator mass contraction plays a role in narrowing the medial elbow joint space; however, repetitive baseball pitching reduced the elbow valgus stability. It has been suggested that sufficient rest and recovery of the flexor-pronator mass function are required to reduce the ulnar collateral ligament injury risk.
  • Prediction of postoperative disability in patients with degenerative diseases of the lumbar spine using preoperative psychological factors
    miki t, samukawa m, Higuchi D, Kondo Y, Watanabe Y, Takebayashi T, Ishida T, kasahara s, Tohyama H
    Mar. 2023
    Scientific journal
  • Transcranial direct current stimulation to the left dorsolateral prefrontal cortex enhances early dexterity skills with the left non-dominant hand: a randomized controlled trial.
    Akihiro Watanabe, Daisuke Sawamura, Hisato Nakazono, Yukina Tokikuni, Hiroshi Miura, Kazuhiro Sugawara, Kanako Fuyama, Harukazu Tohyama, Susumu Yoshida, Shinya Sakai
    Journal of translational medicine, 21, 1, 143, 143, 24 Feb. 2023, [Peer-reviewed], [International Magazine]
    English, Scientific journal, BACKGROUND: The left dorsolateral prefrontal cortex (DLPFC) is involved in early-phase manual dexterity skill acquisition when cognitive control processes, such as integration and complexity demands, are required. However, the effectiveness of left DLPFC transcranial direct current stimulation (tDCS) on early-phase motor learning and whether its effectiveness depends on the cognitive demand of the target task are unclear. This study aimed to investigate whether tDCS over the left DLPFC improves non-dominant hand dexterity performance and determine if its efficacy depends on the cognitive demand of the target task. METHODS: In this randomized, double-blind, sham-controlled trial, 70 healthy, right-handed, young adult participants were recruited. They were randomly allocated to the active tDCS (2 mA for 20 min) or sham groups and repeatedly performed the Purdue Pegboard Test (PPT) left-handed peg task and left-handed assembly task three times: pre-tDCS, during tDCS, and post tDCS. RESULTS: The final sample comprised 66 healthy young adults (mean age, 22.73 ± 1.57 years). There were significant interactions between group and time in both PPT tasks, indicating significantly higher performance of those in the active tDCS group than those in the sham group post tDCS (p < 0.001). Moreover, a greater benefit was observed in the left-handed assembly task performance than in the peg task performance (p < 0.001). No significant correlation between baseline performance and benefits from tDCS was observed in either task. CONCLUSIONS: These results demonstrated that prefrontal tDCS significantly improved early-phase manual dexterity skill acquisition, and its benefits were greater for the task with high cognitive demands. These findings contribute to a deeper understanding of the underlying neurophysiological mechanisms of the left DLPFC in the modulation of early-phase dexterity skill acquisition. TRIAL REGISTRATION: This study was registered in the University Hospital Medical Information Network Clinical Trial Registry in Japan (UMIN000046868), Registered February 8, 2022 https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000053467.
  • Kinesiophobia, self-reported ankle function, and sex are associated with perceived ankle instability in college club sports athletes with chronic ankle instability
    Kentaro Watanabe, Yuta Koshino, Daiki Kawahara, Moeko Akimoto, Masumi Mishina, Kosumi Nakagawa, Tomoya Ishida, Satoshi Kasahara, Mina Samukawa, Harukazu Tohyama
    Physical Therapy in Sport, 61, 45, 50, Elsevier BV, Feb. 2023, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, OBJECTIVE: To investigate the association between sex, self-reported ankle function, pain intensity, kinesiophobia, and perceived ankle instability in athletes with chronic ankle instability (CAI). DESIGN: Cross-Sectional Study. SETTING: University. PARTICIPANTS: College club sports athletes with CAI (n = 42). MAIN OUTCOME MEASURES: Relationships with the Cumberland Ankle Instability Tool (CAIT) score and the Tampa Scale for Kinesiophobia-11 (TSK-11), the Foot and Ankle Ability Measure (FAAM), sex (0: male, 1: female), and ankle pain intensity by the Numeric Rating Scale were explored with multiple regression analysis. RESULTS: The regression model explained 50.3% of the variance of the CAIT score (P < 0.001), and the TSK-11 score (B = -0.382, P = 0.002), the FAAM sports subscale score (B = 0.122, P = 0.038), and sex (B = -2.646, P = 0.031) were significant independent variables for the CAIT score (P < 0.001), while pain intensity was not significant (B = -0.182, P = 0.504). These results indicated that higher TSK-11 score, lower FAAM sports subscale score, and being female were related to lower CAIT score. CONCLUSIONS: Kinesiophobia related to perceived instability along with self-reported function and sex in athletes with CAI. Clinicians should assess the psychological aspects of athletes with CAI.
  • Pelvic Rotation Is Associated With Asymmetry in the Knee Extensor Moment During Double-Leg Squatting After Anterior Cruciate Ligament Reconstruction.
    Tomoya Ishida, Mina Samukawa, Yuta Koshino, Takumi Ino, Satoshi Kasahara, Harukazu Tohyama
    Journal of applied biomechanics, 39, 1, 1, 7, 17 Jan. 2023, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, Asymmetry in knee extensor moment during double-leg squatting was observed after anterior cruciate ligament reconstruction, even after the completion of the rehabilitation program for return to sports. The purpose of this study was to clarify the association between asymmetry in the knee extensor moment and pelvic rotation angle during double-leg squatting after anterior cruciate ligament reconstruction. Twenty-four participants performed double-leg squatting. Kinetics and kinematics during squatting were analyzed using a 3-dimensional motion analysis system with 2 force plates. The limb symmetry index of knee extensor moment was predicted by the pelvic rotation angle (R2 = .376, P = .001). In addition, the pelvic rotation and the limb symmetry index of the vertical ground reaction force independently explained the limb symmetry index of the knee extensor moment (R2 = .635, P < .001, β of pelvic rotation = -0.489, β of vertical ground reaction force = 0.524). Pelvic rotation toward the involved limb was associated with a smaller knee extensor moment in the involved limb than in the uninvolved limb. The assessment of pelvic rotation would be useful for partially predicting asymmetry in the knee extensor moment during double-leg squatting. Minimizing pelvic rotation may improve the asymmetry in the knee extensor moment during double-leg squatting after anterior cruciate ligament reconstruction.
  • Evaluation of Lower-Limb Kinematics during Timed Up and Go (TUG) Test in Subjects with Locomotive Syndrome (LS) Using Wearable Gait Sensors (H-Gait System).
    Yoshiaki Kataoka, Yuki Saito, Ryo Takeda, Tomoya Ishida, Shigeru Tadano, Teppei Suzuki, Kentaro Nakamura, Akimi Nakata, Satoshi Osuka, Satoshi Yamada, Mina Samukawa, Harukazu Tohyama
    Sensors (Basel, Switzerland), 23, 2, 06 Jan. 2023, [Peer-reviewed], [Invited], [Last author, Corresponding author], [International Magazine]
    English, Scientific journal, Few studies have dealt with lower-limb kinematics during the timed up and go (TUG) test in subjects with locomotive syndrome (LS). This study aimed to evaluate the characteristics of lower-limb kinematics during the TUG test in subjects with LS using the wearable sensor-based H-Gait system. A total of 140 participants were divided into the non-LS (n = 28), the LS-stage 1 (n = 78), and LS-stage 2 (n = 34) groups based on the LS risk test. Compared with the non-LS group, the LS-stage 1 and LS-stage 2 groups showed significantly smaller angular velocity of hip and knee extension during the sit-to-stand phase. The LS-stage 2 group showed significantly smaller peak angles of hip extension and flexion during the walking-out phase compared to the non-LS group. These findings indicate that the evaluation of the lower-limb kinematics during the TUG test using the H-Gait system is highly sensitive to detect LS, compared with the evaluation of the lower-limb kinematics when simply walking.
  • Dual-Task Interference Slows Down Proprioception.
    Linjing Jiang, Satoshi Kasahara, Tomoya Ishida, Yuting Wei, Ami Chiba, Mina Samukawa, Harukazu Tohyama
    Motor control, 27, 3, 1, 15, 04 Jan. 2023, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, It is well-known that multitasking impairs the performance of one or both of the concomitant ongoing tasks. Previous studies have mainly focused on how a secondary task can compromise visual or auditory information processing. However, despite dual tasking being critical to motor performance, the effects of dual-task performance on proprioceptive information processing have not been studied yet. The purpose of the present study was, therefore, to investigate whether sensorimotor task performance would be affected by the dual task and if so, in which phase of the sensorimotor task performance would this negative effect occur. The kinematic variables of passive and active knee movements elicited by the leg drop test were analyzed. Thirteen young adults participated in the study. The dual task consisted of performing serial subtractions. The results showed that the dual task increased both the reaction time to counteract passive knee-joint movements in the leg drop test and the threshold to detect those movements. The dual task did not affect the speed and time during the active knee movement and the absolute angle error between the final and the target knee angles. Furthermore, the results showed that the time to complete the sensorimotor task was prolonged in dual tasking. Our findings suggest that dual tasking reduces motor performance due to slowing down proprioceptive information processing without affecting movement execution.
  • Early Changes in Postural Balance Following Inverted V-Shaped High Tibial Osteotomy in Patients With Knee Osteoarthritis.
    Kento Sabashi, Takeshi Chiba, Koji Iwasaki, Tomohiro Onodera, Eiji Kondo, Norimasa Iwasaki, Harukazu Tohyama
    Journal of applied biomechanics, 39, 2, 1, 6, 01 Jan. 2023, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, Patients with knee osteoarthritis and varus knee deformity have impaired postural balance, resulting in decreased walking performance and an increased risk of falls. This study aimed to investigate the early changes in the postural balance following inverted V-shaped high tibial osteotomy (HTO). Fifteen patients with medial knee osteoarthritis were recruited. Postural balance was assessed using the center-of-pressure (COP) data during single-leg standing before and 6 weeks after inverted V-shaped HTO. The maximum range, mean velocity, and area of COP movements in the anteroposterior and mediolateral directions were analyzed. Preoperative and postoperative visual analog scale for knee pain was assessed. The maximum range of COP in the mediolateral direction decreased (P = .017), whereas the mean velocity of COP in the anteroposterior direction increased 6 weeks postoperatively (P = .011). The visual analog scale score for knee pain significantly improved at 6 weeks postoperatively (P = .006). Valgus correction with inverted V-shaped HTO resulted in improved postural balance in the mediolateral direction and good short-term clinical outcomes early following surgery. Early rehabilitation after inverted V-shaped HTO should focus on postural balance in the anteroposterior direction.
  • Inertial Sensor-Based Assessment of Static Balance in Athletes with Chronic Ankle Instability
    Yuta Koshino, Moeko Akimoto, Daiki Kawahara, Kentaro Watanabe, Tomoya Ishida, Mina Samukawa, Satoshi Kasahara, Harukazu Tohyama
    Journal of Sports Science and Medicine, 22, 1, 36, 43, Jan. 2023, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, The Balance Error Scoring System (BESS), a subjective examiner-based assessment, is often employed to assess postural balance in individuals with chronic ankle instability (CAI); however, inertial sensors may enhance the detection of balance deficits. This study aimed to compare the BESS results between the CAI and healthy groups using conventional BESS scores and inertial sensor data. The BESS test (six conditions: double-leg, single-leg, and tandem stances on firm and foam surfaces, respectively) was performed for the CAI (n = 16) and healthy control (n = 16) groups with inertial sensors mounted on the sacrum and anterior shank. The BESS score was calculated visually by the examiner by counting postural sway as an error based on the recorded video. The root mean square for resultant acceleration (RMSacc) in the anteroposterior, mediolateral, and vertical directions was calculated from each inertial sensor affixed to the sacral and shank surfaces during the BESS test. The mixed-effects analysis of variance and unpaired t-test were used to assess the effects of group and condition on the BESS scores and RMSacc. No significant between-group differences were found in the RMSacc of the sacral and shank surfaces, and the BESS scores (P > 0.05), except for the total BESS score in the foam condition (CAI: 14.4 ± 3.7, control: 11.7 ± 3.4; P = 0.039). Significant main effects of the conditions were found with respect to the BESS scores and RMSacc for the sacral and anterior shank (P < 0.05). The BESS test with inertial sensors can detect differences in the BESS conditions for athletes with CAI. However, our method could not detect any differences between the CAI and healthy groups.
  • Effects of Posterior Spinal Correction and Fusion on Postural Stability in Patients with Adolescent Idiopathic Scoliosis.
    Satoshi Osuka, Hideki Sudo, Katsuhisa Yamada, Hiroyuki Tachi, Kentaro Watanabe, Fuma Sentoku, Takeshi Chiba, Norimasa Iwasaki, Masahiko Mukaino, Harukazu Tohyama
    Journal of clinical medicine, 12, 1, 29 Dec. 2022, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, The present study aimed to assess the effects of posterior spinal correction and fusion on postural stability in patients with adolescent idiopathic scoliosis (AIS). The study included 41 female patients with AIS at our institution. All patients performed three 10 s single-leg standing trials on a force plate. The center of pressure (COP) was measured preoperatively, and at 1 week and 6 months postoperatively. The postural stability parameters were absolute minimum time-to-boundary (TTB), mean of the minimum TTB, mean COP velocity, standard deviation, range, and 95% confidence ellipse area. One-way repeated analysis of variance or Friedman test was applied to the postural stability parameters. Multiple comparisons were performed using the Bonferroni correction. The absolute minimum TTB and the mean minimum TTB showed a significant increase 6 months post-operation as compared to preoperatively and 1 week postoperatively. The COP velocity significantly decreased at 6 months post-operation compared to preoperatively and 1 week postoperatively. These changes in postural stability indicate that spinal correction and fusion can be considered to improve postural stability during single-leg standing tests in the postoperative period.
  • The center of pressure position in combination with ankle dorsiflexion and trunk flexion is useful in predicting the contribution of the knee extensor moment during double-leg squatting
    Tomoya Ishida, Mina Samukawa, Satoshi Kasahara, Harukazu Tohyama
    BMC Sports Science, Medicine and Rehabilitation, 14, 1, 127, 127, Springer Science and Business Media LLC, Dec. 2022, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, Abstract

    Background

    Squatting exercises are commonly used in rehabilitation for knee joint disorders; in these exercises, control of knee extensor moment is important to enhance training effects and to avoid adverse effects. Ankle dorsiflexion and trunk flexion are widely used to reduce knee extensor moments during squatting, but the increased load on the low back is a concern. The purpose of this study was to determine whether the anterior–posterior (AP) center-of-pressure (COP) position and the AP-COP position in combination with ankle dorsiflexion and trunk flexion angles can predict the contribution of the knee extensor moment during double-leg squatting.

    Methods

    Twenty-eight healthy individuals (14 female and 14 male participants, age 22.8 ± 1.3 years) performed three sets of five consecutive double-leg squats. Kinematics and kinetics were analyzed using a three-dimensional motion analysis system with force plates. Univariate and multivariate regression analyses were performed to predict the contribution of the knee extensor moment (% total support moment) from AP-COP position, ankle dorsiflexion, and trunk flexion.

    Results

    The AP-COP position was a significant predictor of the knee extensor moment contribution (R2 = 0.168, P = 0.030). Multivariate analysis showed that the ankle dorsiflexion angle (ΔR2 = 0.561, β = 0.842) and AP-COP position (ΔR2 = 0.296, β =  − 0.499) predicted the knee extensor moment contribution (model R2 = 0.857, P < 0.001). Additionally, the combination of trunk flexion (ΔR2 = 0.429, β =  − 0.613) and AP-COP position (ΔR2 = 0.109, β =  − 0.332) predicted the knee extensor moment contribution (model R2 = 0.538, P < 0.001). The limb symmetry index of the knee extensor moment was significantly associated with that of the AP-COP position (R2 = 0.493, P < 0.001) but not with that of the ankle dorsiflexion angle (P = 0.057).

    Conclusions

    The AP-COP position can predict the contribution of the knee extensor moment and improve the prediction when combined with ankle dorsiflexion and trunk flexion. The present findings suggest that intervention focusing on the AP-COP position in combination with ankle dorsiflexion or trunk flexion would be useful to coordinate the contribution of the knee extensor moment during double-leg squatting.
  • The effects of relative trunk rotation velocity on ball speed and elbow and shoulder joint torques during baseball pitching.
    Yousuke Tanaka, Tomoya Ishida, Takumi Ino, Yuki Suzumori, Mina Samukawa, Satoshi Kasahara, Harukazu Tohyama
    Sports biomechanics, 1, 13, 12 Oct. 2022, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, In baseball pitching, suppressing trunk rotation while rotating the pelvis in the early phase of arm cocking is important for throwing a fast ball. However, quantitative evaluation of trunk rotation during pitching has not been established, and its associations with elbow and shoulder torques are unclear. The purpose of this study was to examine the correlation of a new measure of trunk rotation suppression with ball speed and elbow and shoulder torques during pitching. Eighteen adult male baseball pitchers (21.7 ± 1.2 years old) participated. Three qualified pitches were analysed using a three-dimensional motion capture system. Trunk rotation velocity, normalised to the peak velocity, was derived at the time of peak pelvic velocity. Pearson's correlation coefficient was used to determine correlations. The normalised trunk rotation velocity at the peak pelvic velocity was significantly correlated with elbow valgus torque (R = -0.508, P = 0.032), shoulder external rotation torque (R = -0.507, P = 0.032) and ball speed (R = -0.504, P = 0.033). A smaller normalised trunk rotation angular velocity at the time of peak pelvic rotation velocity could increase ball speed but may also increase elbow and shoulder torques among pitchers who demonstrate trunk rotation after foot contact.
  • Psychological readiness at 9 months after anterior cruciate ligament reconstruction -which factors affect?
    Makoto Suzuki, Tomoya Ishida, Hisashi Matsumoto, Satoru Kaneko, Chiharu Inoue, Yoshimitsu Aoki, Harukazu Tohyama, Mina Samukawa
    Physical therapy in sport : official journal of the Association of Chartered Physiotherapists in Sports Medicine, 58, 74, 79, 04 Oct. 2022, [Peer-reviewed], [International Magazine]
    English, Scientific journal, OBJECTIVE: To investigate the association of psychological readiness at 9 months after anterior cruciate ligament reconstruction (ACLR) with knee strength and range-of-motion (ROM) at 3 and 9 months postoperatively. DESIGN: Retrospective cohort study. SETTING: Private orthopedic hospital. PARTICIPANTS: Seventy-eight patients after ACLR. MAIN OUTCOMES MEASURES: The participants completed the anterior cruciate ligament-return to sport after injury (ACL-RSI) scale as an assessment of psychological readiness at 9 months after ACLR. Isometric and isokinetic quadriceps and hamstring strength were measured by a dynamometer at 3 and 9 months postoperatively. Knee extension and flexion ROM were measured in 5° increments with a standard goniometer at 3 and 9 months postoperatively. RESULTS: Univariate regression analysis showed that age, limb symmetry index (LSI) of quadriceps strength at 3 and 9 months, and knee extension ROM deficit (>5°) at 3 and 9 months were associated with ACL-RSI scores at 9 months (P < 0.05). Age and LSI of quadriceps strength at 3 months remained significant predictors of ACL-RSI scores at 9 months in multiple regression analysis (R2 = 0.20, P < 0.001). CONCLUSIONS: Early improvements in quadriceps strength after ACLR may have a positive impact on psychological readiness at 9 months postoperatively.
  • Rate of Torque Development in the Quadriceps after Anterior Cruciate Ligament Reconstruction with Hamstring Tendon Autografts in Young Female Athletes.
    Makoto Suzuki, Tomoya Ishida, Mina Samukawa, Hisashi Matsumoto, Yu Ito, Yoshimitsu Aoki, Harukazu Tohyama
    International journal of environmental research and public health, 19, 18, 18 Sep. 2022, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, This study aims to compare the limb symmetry index (LSI) of the rate of torque development (RTD) of the quadriceps with that of the peak torque after anterior cruciate ligament reconstruction (ACLR) using semitendinosus and gracilis tendon (STG) autografts and to investigate the associations of the LSI of torque parameters with patient-reported knee function. The participants included 23 female athletes after ACLR with STG grafts. Isometric quadriceps tests were performed using an isokinetic dynamometer. The peak torque, RTD100 (0 to 100 ms) and RTD200 (100 to 200 ms) were determined using torque-time curves. Comparisons of the LSI of torque parameters was performed by ANOVA. Univariate regression analysis was used to examine the relationship between the LSI of torque parameters and the patient-reported knee function. The LSIs of the peak torque and RTD200 were significantly lower than that of the RTD100 (p = 0.049, p = 0.039, respectively). Regression analysis showed that the LSI of the peak torque was associated with the patient-reported knee function (R2 = 0.40, p = 0.001). It would be useful to evaluate the peak torque in young female athletes under the age of 18 and at 8-10 months after ACLR with STG grafts.
  • Lower limb kinematics during single leg landing in three directions in individuals with chronic ankle instability
    Daiki Kawahara, Yuta Koshino, Kentaro Watanabe, Moeko Akimoto, Tomoya Ishida, Satoshi Kasahara, Mina Samukawa, Harukazu Tohyama
    Physical Therapy in Sport, 57, 71, 77, Elsevier BV, Sep. 2022, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, OBJECTIVES: To compare the lower limb kinematics of participants with chronic ankle instability (CAI) and healthy participants during forward, lateral, and medial landings. DESIGN: Cross-sectional study. SETTING: Laboratory. PARTICIPANTS: Eighteen athletes with CAI and 18 control athletes. MAIN OUTCOME MEASURES: Hip, knee, and ankle joint kinematics during forward, lateral, and medial single-leg landings were compared between the groups using two-way ANOVA for discrete values and statistical parametric mapping two-sample t-tests for time-series data. RESULTS: The CAI group had significantly greater ankle dorsiflexion than the control group (P ≤ 0.013), which was observed from the pre-initial contact (IC) for lateral and medial landings and post-IC for forward landing. The CAI group showed greater knee flexion than the control group from the IC for lateral landing and post-IC for forward landing (P ≤ 0.014). No significant differences in ankle inversion kinematics were found between the CAI and control groups. Lateral landing had a greater peak inversion angle and velocity than forward and medial landings (P < 0.001). Medial landing had a greater inversion velocity than forward landing (P < 0.001). CONCLUSIONS: This study suggests that individuals with CAI show feedforward protective adaptations in the pre-landing phase for lateral and medial landings.
  • Effects of Changing Center of Pressure Position on Knee and Ankle Extensor Moments During Double-Leg Squatting
    Tomoya Ishida, Mina Samukawa, Daisuke Endo, Satoshi Kasahara, Harukazu Tohyama
    Journal of Sports Science and Medicine, 21, 3, 341, 346, Journal of Sports Science and Medicine, 15 Jun. 2022, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, The effects of changes in the anterior-posterior center of pressure (AP-COP) position on the lower limb joint moments during double-leg squatting remain unclear. The purpose of this study was to determine the effects of AP-COP positional changes on the hip, knee, and ankle extensor moments during double-leg squatting. Sixteen male participants (22.1 ± 1.5 years) performed double-leg squatting under two conditions (anterior and posterior COP conditions) with visual feedback on their COP positions. Kinematics and kinetics were analyzed using a three-dimensional motion analysis system and force plates. The hip, knee and ankle flexion angles and extensor moments at peak vertical ground reaction force were compared between the two conditions using paired t tests. The COP position was 53.5 ± 2.4% of the foot length, starting from the heel, under the anterior condition and 44.4 ± 2.1% under the posterior condition (P < 0.001). The knee extensor moment was significantly smaller under the anterior than the posterior COP condition (P = 0.003, 95% confidence interval (CI) -0.087 to -0.021 Nm/kg/m), while the ankle extensor moment significantly larger under the anterior COP condition than under the posterior COP condition (P < 0.001, 95% CI 0.113 to 0.147 Nm/kg/m). There was no significant difference in hip extensor moment (P = 0.431). The ankle dorsiflexion angle was significantly larger under the anterior than the posterior COP condition (P = 0.003, 95% CI 0.6 to 2.6°), while there was no difference in trunk, hip, or knee flexion angle. The present results indicate that changes in the AP-COP position mainly affect the ankle and knee extensor moments during double-leg squatting, while the effect on the lower limb joint and trunk flexion angles was limited. Visual feedback on the AP-COP position could be useful for modifying the ankle and knee extensor moments during double-leg squatting.
  • Evaluation of gait characteristics in subjects with locomotive syndrome using wearable gait sensors.
    Yuki Saito, Tomoya Ishida, Yoshiaki Kataoka, Ryo Takeda, Shigeru Tadano, Teppei Suzuki, Kentaro Nakamura, Akimi Nakata, Satoshi Osuka, Satoshi Yamada, Mina Samukawa, Harukazu Tohyama
    BMC musculoskeletal disorders, 23, 1, 457, 457, 14 May 2022, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, BACKGROUND: Individuals with locomotive syndrome (LS) require nursing care services owing to problems with locomotion and the musculoskeletal system. Individuals with LS generally have a reduced walking speed compared with those without LS. However, differences in lower-limb kinematics and gait between individuals with and without LS are not fully understood. This study aimed to clarify the characteristics of the gait kinematics of individuals with LS using wearable sensors. METHODS: We assessed 125 participants (mean age 73.0 ± 6.7 years) who used a public health promotion facility. Based on the 25-question Geriatric Locomotive Function Scale (GLFS-25), these participants were grouped into the non-LS (GLFS-25 < 7), LS-stage 1 (GLFS-25 7-16), and LS-stage 2 (GLFS-25 ≥ 16) groups (larger GLFS-25 scores indicate worse locomotive ability). Spatiotemporal parameters and lower-limb kinematics during the 10-m walk test were analyzed by the "H-Gait system", which is a motion analysis system that was developed by the authors and is based on seven inertial sensors. The peak joint angles during the stance and swing phases, as well as the gait speed, cadence, and step length were compared among all groups. RESULTS: There were 69 participants in the non-LS group, 33 in the LS-stage 1 group, and 23 in the LS-stage 2 group. Compared with the non-LS group, the LS-stage 2 group showed significantly smaller peak angles of hip extension (9.5 ± 5.3° vs 4.2 ± 8.2°, P = 0.002), hip flexion (34.2 ± 8.8° vs 28.5 ± 9.5°, P = 0.026), and knee flexion (65.2 ± 18.7° vs 50.6 ± 18.5°, P = 0.005). The LS-stage 1 and LS-stage 2 groups had a significantly slower mean gait speed than the non-LS group (non-LS: 1.3 ± 0.2 m/s, LS-stage 1: 1.2 ± 0.2 m/s, LS-stage 2: 1.1 ± 0.2 m/s, P < 0.001). CONCLUSIONS: The LS-stage 2 group showed significantly different lower-limb kinematics compared with the non-LS group, including smaller peak angles of hip extension, hip flexion, and knee flexion. It would be useful to assess and improve these small peak joint angles during gait for individuals classified as LS-stage 2.
  • Warm-Up Intensity and Time-Course Effects on Jump Height under Cold Conditions.
    Itaru Chiba, Mina Samukawa, Kazuki Takizawa, Yuriko Nishikawa, Tomoya Ishida, Satoshi Kasahara, Masanori Yamanaka, Harukazu Tohyama
    International journal of environmental research and public health, 19, 9, 09 May 2022, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, With this study, we aimed to investigate the effects of different warm-up intensities on counter-movement jump (CMJ) performance over time under cold conditions. Eleven male collegiate athletes volunteered. The participants performed high-intensity warm-up (HWU) at 80% VO2max and moderate-intensity warm-up (MWU) at 60% VO2max for 15 min on a bicycle ergometer in a laboratory room at 10 °C. CMJ height, vastus lateralis muscle temperature, heart rate, and perceived fatigue were measured before warm-up (Pre), immediately after (Post 0), 10 min after (Post 10), and 20 min after (Post 20). Significant main effects and interactions were found for CMJ height (time, p < 0.001 and ηp2 = 0.859; interaction, p = 0.007 and ηp2 = 0.327). HWU significantly increased CMJ height at Post 0 to Post 20 compared to that at Pre (p < 0.01), whereas MWU increased CMJ height at Post 0 only compared to that at Pre (p < 0.001). The results indicate that HWU achieved an increase in CMJ height for 20 min. MWU changed CMJ height instantly, but the change did not last compared to HWU in a cold environment.
  • The Influence of Low Energy Availability on Bone Mineral Density and Trabecular Bone Microarchitecture of Pubescent Female Athletes: A Preliminary Study.
    Nodoka Ikegami, Mina Samukawa, Mikako Sakamaki-Sunaga, Makoto Sugawara, Shizuka Torashima, Tomoya Ishida, Satoshi Kasahara, Harukazu Tohyama
    International journal of environmental research and public health, 19, 9, 04 May 2022, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, The influence of low energy availability (LEA) on bone mineral density (BMD) and trabecular bone microarchitecture in pubescent female athletes is unclear. This study aimed to investigate the influence of LEA on BMD and trabecular bone microarchitecture in 21 pubescent female athletes (age, 12-15 years; 11 track and field athletes, 10 gymnasts). We used two indices to assess LEA: energy availability and the percent of ideal body weight. Dual-energy X-ray absorptiometry was used to obtain total body less head, lumbar spine BMD Z-scores, and lumbar trabecular bone scores (TBS). Pearson's or Spearman's correlation coefficients were used to assess the relationship among EA, percent of ideal body weight, and bone parameters. The threshold for statistical significance was set at p < 0.05. The percent of ideal body weight was significantly correlated with the BMD Z-scores of the total body less head (r = 0.61; p < 0.01), lumbar spine (r = 0.55; p < 0.01), and lumbar TBS (r = 0.47; p = 0.03). However, energy availability was not correlated with bone parameters. These findings suggest that screening for low ideal body weight may be a useful predictor of low BMD and insufficient trabecular bone microarchitecture in pubescent female athletes.
  • Sex difference in frontal plane hip moment in response to lateral trunk obliquity during single-leg landing.
    Shohei Taniguchi, Tomoya Ishida, Masanori Yamanaka, Ryo Ueno, Ryohei Ikuta, Masato Chijimatsu, Mina Samukawa, Yuta Koshino, Satoshi Kasahara, Harukazu Tohyama
    BMC sports science, medicine & rehabilitation, 14, 1, 70, 70, 15 Apr. 2022, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, BACKGROUND: Lateral trunk obliquity during landing is a characteristic of anterior cruciate ligament (ACL) injuries in female athletes and affects their knee and hip kinetics and kinematics. However, it is unclear whether these effects differ between females and males. The purpose of this study was to compare the effects of lateral trunk obliquity on knee and hip kinetics and kinematics in females and males during single-leg landing. METHODS: Eighteen female (aged 22.1 ± 1.5 years) and 18 male participants (aged 21.8 ± 1.1 years) performed single-leg landings under two conditions: (1) without any instructions about trunk position (natural) and (2) with leaning their trunks laterally 15° from the vertical line (trunk obliquity). The kinetics and kinematics of their hip and knee were analyzed using a three-dimensional motion analysis with a force plate. Two-way repeated-measures ANOVA (sex × trunk obliquity) and Bonferroni pairwise comparisons were conducted. RESULTS: The trunk obliquity angle at initial contact was significantly greater in the trunk-obliquity landing condition than in the natural landing condition (natural 4.0 ± 2.2°, trunk-obliquity 15.1 ± 3.6°, P < 0.001) with no sex difference (95% CI - 1.2 to 2.2°, P = 0.555). The peak knee abduction moment was significantly larger in the trunk-obliquity landing condition than in the natural landing condition (trunk-obliquity, 0.09 ± 0.07 Nm/kg/m; natural, 0.04 ± 0.06 Nm/kg/m; P < 0.001), though there was no sex or interaction effect. A significant interaction between sex and landing condition was found for the peak hip abduction moment (P = 0.021). Males showed a significantly larger peak hip abduction moment in the trunk-obliquity landing condition than in the natural landing condition (95% CI 0.05 to 0.13 Nm/kg/m, P < 0.001), while females showed no difference in the peak hip abduction moment between the two landing conditions (95% CI - 0.02 to 0.06 Nm/kg/m, P = 0.355). CONCLUSIONS: The knee abduction moment increased with a laterally inclined trunk for both female and male participants, while the hip abduction moment increased in males but not in females. It may be beneficial for females to focus on frontal plane hip joint control under lateral trunk-obliquity conditions during single-leg landing.
  • Energy dissipation during single-leg landing from three heights in individuals with and without chronic ankle instability.
    Kentaro Watanabe, Yuta Koshino, Tomoya Ishida, Mina Samukawa, Harukazu Tohyama
    Sports biomechanics, 21, 4, 408, 427, Apr. 2022, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, Inadequate energy dissipation during landing may increase the risk of ankle sprain. Mechanical demands (landing height) in landing tasks may affect the biomechanical differences between individuals with and without chronic ankle instability (CAI). However, energy dissipation strategies during landing from various heights in individuals with CAI are unclear. The purpose of this study was to compare the effect of landing height on lower extremity biomechanics between individuals with and without CAI. Eleven participants in each of the CAI and Control group performed a single-leg landing from three heights (30, 40, and 50 cm). We calculated the contribution of each joint to total energy dissipation at 50-ms intervals during 0-200 ms post-initial contact (IC). Peak joint angles and moments and joint stiffnesses were calculated during 0-200 ms post-IC. Two-way mixed analysis of variance revealed significant group-by-height interactions for hip energy dissipation at 101-150 ms post-IC and peak ankle plantarflexion and hip extension moment. These significant interactions suggested that the effects of landing height on the ankle and hip joints differ between individuals with and without CAI. The effect of mechanical demands on altered landing biomechanics among CAI populations should be considered in biomechanical studies and clinical practice.
  • Torque-angle curve of the knee flexors in athletes with a prior history of hamstring strain.
    Kentaro Mikami, Mina Samukawa, Kensuke Oba, Kentaro Nakamura, Yuki Suzumori, Yuko Ishida, Hisashi Matsumoto, Yoshimitsu Aoki, Tomoya Ishida, Masanori Yamanaka, Harukazu Tohyama
    Physical therapy in sport : official journal of the Association of Chartered Physiotherapists in Sports Medicine, 54, 29, 35, Mar. 2022, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, OBJECTIVES: To investigate the knee flexor torque-angle curve after hamstring strain injury using different muscle action types and angular velocities. DESIGN: Cross-sectional. SETTING: Controlled laboratory. PARTICIPANTS: Thirteen collegiate athletes injured hamstring strain (21.0 ± 0.8 years; 173.9 ± 6.5 cm; 70.1 ± 10.5 kg). MAIN OUTCOME MEASURES: Concentric and eccentric knee flexor torque was measured at 60 & 300°/sec. Peak torque and average torque every 10° were determined from torque-angle curve and injured side was compared with non-injured side. RESULTS: No significant differences were found in the concentric muscle actions. However, the eccentric peak torque was significantly lower on the injured side at 60°/sec (p = 0.048) and at 300°/sec (p = 0.002). The average eccentric torque was significantly lower on the injured side at 60°/sec from 10° to 20° of knee flexion (p = 0.012-0.018) and at 300°/sec from 10° to 60° of knee flexion (p = 0.005-0.049). CONCLUSION: The knee flexor torque-angle curve changes with eccentric muscle action after hamstring injury. Eccentric torque declines were close to full knee extension at 60°/sec and a wide range of knee flexion at 300°/sec. The assessment and rehabilitation of eccentric hamstring strength may be important to consider the effect of the angular velocity after hamstring strain injury.
  • Feasibility of an Ultrasound-Based Method for Measuring Talar Displacement during the Anterior Drawer Stress Test Using a Telos Device: A Preliminary Study.
    Kaori Tsutsumi, Utayo Nakaya, Yuta Koshino, Mari Tateno, Kazuhisa Matsumoto, Mai Tanaka, Mika Yokoyama, Tatsunori Horie, Mina Samukawa, Tamotsu Kamishima, Harukazu Tohyama
    International journal of environmental research and public health, 19, 4, 18 Feb. 2022, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, This study was conducted to measured talar displacement using ultrasound during an anterior drawer test (ADT) with a Telos device. Five adults (3 men and 2 women; 8 ankles; mean age: 23.2 y) with a history of ankle sprain and eight adults (5 men and 3 women; 16 ankles; mean age: 22.1 y) without a history of ankle sprain were recruited into a history of ankle sprain (HAS) and a control group, respectively. Talar displacement was observed in response to load forces applied by a Telos device during the ultrasound stress imaging test. The ultrasound probe was placed 5 mm inside from the center of the Achilles tendon on the posterior ankle along the direction of the major axis. The inter-rater reliability for the present method was classified as good and excellent (ICC(2,2) = 0.858 and 0.957 at 120 N and 150 N, respectively) in the control group and excellent (ICC(2,2) = 0.940 and 0.905 at 120 N and 150 N, respectively) in the HAS group, according to specific intraclass correlation coefficient values. We found that talar displacement during the ADT was lower in the HAS group than in the control group. Analysis of the receiver operating characteristic curve revealed that the quantitative ultrasound-based ADT using a Telos device was superior to the X-ray-based test in detecting reduced ankle joint mobility during the ADT (area under the curve of 0.905 and 0.726 at a force of 150 N using ultrasound-based and X-ray-based tests, respectively). Further investigation is needed; nevertheless, this preliminary study suggests that the ultrasound-based quantitative ADT using a Telos device might detect talar displacement more sensitively than the conventional stress X-ray.
  • Combined treatment with exercise and α5GABAAR inhibitor promotes motor function recovery after intracerebral hemorrhage.
    Takahiro Inoue, Yasuyuki Takamatsu, Taichi Nishio, Kiho Soma, Misato Okamura, Harukazu Tohyama, Hiroshi Maejima
    Neuroscience letters, 766, 136344, 136344, 01 Jan. 2022, [Peer-reviewed], [International Magazine]
    English, Scientific journal, The present study aimed to examine the synergistic effects of exercise and pharmacological inhibition of the α5 subunit-containing gamma-aminobutyric acid (GABA)A receptors (α5GABAAR) on motor function recovery after intracerebral hemorrhage (ICH). Wistar rats were divided into five groups (n = 8 per group): SHAM, ICH, ICH + exercise (ICH + EX), ICH + L-655,708 (ICH + L6), and ICH + L-655,708 and exercise (ICH + L6EX) groups. ICH was induced by microinjection of a collagenase solution. The ICH + EX and ICH + L6EX groups exercised on a treadmill (12 m/min for 30 min/day). L-655,708 (0.5 mg/kg), a negative allosteric modulator of α5GABAAR, was administered intraperitoneally to the ICH + L6 and ICH + L6EX groups. Each intervention was initiated 1 week after the ICH surgery and was performed for 3 weeks, followed by tissue collection, including the motor cortex and spinal cord. At 4 weeks after ICH, significant motor recovery was found in the ICH + L6EX group compared to the ICH group. L-655,708 administration increased brain-derived neurotrophic factor (BDNF) expression in the cortex. Regarding neuroplastic changes in the spinal cord, rats in the ICH + L6EX group showed a significant increase in several neuroplastic markers: 1) BDNF, 2) growth-associated protein 43 as an axonal sprouting marker, 3) synaptophysin as a synaptic marker, and 4) Nogo-A as an axonal growth inhibitor. This study is the first to demonstrate that combined treatment with exercise and α5GABAAR inhibitor effectively promoted motor function recovery after ICH. Regarding the underlying mechanism of post-ICH recovery with the combined treatment, the present study highlights the importance of both growth and inhibitory modification of axonal sprouting in the spinal cord.
  • The deficits of isometric knee flexor strength in lengthened hamstring position after hamstring strain injury.
    Ginji Nara, Mina Samukawa, Kensuke Oba, Yuta Koshino, Tomoya Ishida, Satoshi Kasahara, Harukazu Tohyama
    Physical therapy in sport : official journal of the Association of Chartered Physiotherapists in Sports Medicine, 53, 91, 96, Jan. 2022, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, OBJECTIVE: To investigate the effects of knee flexion angle on peak torque, rate of torque development (RTD) during isometric contraction and hamstring flexibility after hamstring strain injury (HSI). DESIGN: Cross-sectional. SETTING: Controlled laboratory research. PARTICIPANTS: Fourteen male athletes with a history of HSI and 14 athletes without HSI (controls). MAIN OUTCOME MEASURES: Hamstring flexibility was evaluated using active knee extension test. Isometric knee flexion peak torque and RTD were determined at 30°, 60°, and 90° of knee flexion measured by an isokinetic dynamometer. RESULTS: Individuals with a history of HSI had statistically significant, moderate deficits in isometric peak torque at 30° of knee flexion (P = 0.037; effect size = 0.55) in the HSI limb than in the uninjured limb, but not at 60° and 90° of knee flexion. In the control group, no significant differences in isometric peak torque at any angle were found between limbs. No differences in peak RTD and flexibility were found between limbs in both groups. CONCLUSIONS: Isometric peak torque at 30° of knee flexion was lower in the injured limb than in the uninjured limb. Isometric strength deficits after HSI tended to be affected by lengthened hamstring angles.
  • Effects of Intermittent and Continuous Static Stretching on Range of Motion and Musculotendinous Viscoelastic Properties Based on a Duration-Matched Protocol.
    Kensuke Oba, Mina Samukawa, Yosuke Abe, Yukino Suzuki, Miho Komatsuzaki, Satoshi Kasahara, Tomoya Ishida, Harukazu Tohyama
    International journal of environmental research and public health, 18, 20, 11 Oct. 2021, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, The different effects of intermittent and continuous stretching on the mechanical properties of the musculotendinous complex have been unclear. This study aimed to compare the effects of intermittent and continuous stretching for the same duration on the range of motion (ROM), passive resistive torque (PRT), and musculotendinous stiffness (MTS) of ankle plantar flexors. Eighteen healthy young men participated in the study. Intermittent (four sets × 30 s) and continuous stretching (one set × 120 s) were performed in random orders on two separate days. Both stretching protocols were conducted using a dynamometer with a constant torque applied. ROM and PRT were determined using a dynamometer, and MTS was calculated using the torque-angle relationship measured before and after stretching. Two-way repeated measures analysis of variance was performed for all parameters. Both intermittent and continuous stretching significantly increased ROM and decreased PRT and MTS (p < 0.05). Intermittent stretching led to greater changes in ROM and PRT than continuous stretching. However, the reduction in MTS did not differ between the two conditions. These results suggest that intermittent stretching is more effective in increasing ROM and changing the mechanical properties of the musculotendinous complex.
  • Improvements in asymmetry in knee flexion motion during landing are associated with the postoperative period and quadriceps strength after anterior cruciate ligament reconstruction.
    Tomoya Ishida, Mina Samukawa, Makoto Suzuki, Hisashi Matsumoto, Yu Ito, Miku Sakashita, Yoshimitsu Aoki, Masanori Yamanaka, Harukazu Tohyama
    Research in sports medicine (Print), 1, 11, 18 Aug. 2021, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, This study investigated the relationship between quadriceps strength and knee kinematics during a drop vertical jump (DVJ) at 6, 9 and 12 months after anterior cruciate ligament reconstruction (ACLR) in 9 male and 22 female athletes (16.6 ± 2.1 years old). Isokinetic quadriceps strength was measured by a dynamometer (Biodex System 3). Knee flexion excursion was assessed using two-dimensional analysis. Knee flexion excursion at 6 months was significantly smaller in the involved limb than in the uninvolved limb independent of quadriceps strength (56.7° ± 9.3°, 63.4° ± 11.4°, P < 0.001). At 9 months, only the low quadriceps strength group demonstrated a similar interlimb difference (57.2°± 12.3°, 63.3° ± 10.5°, P < 0.001). At 12 months, there was no significant interlimb difference in knee flexion excursion regardless of quadriceps strength. These findings indicate that restoration in symmetrical knee flexion excursion during a DVJ requires rehabilitation as well as quadriceps strength.
  • Changes in postural control strategy during quiet standing in individuals with knee osteoarthritis.
    Kento Sabashi, Satoshi Kasahara, Harukazu Tohyama, Takeshi Chiba, Yuta Koshino, Tomoya Ishida, Mina Samukawa, Masanori Yamanaka
    Journal of back and musculoskeletal rehabilitation, 02 Aug. 2021, [Peer-reviewed], [International Magazine]
    English, Scientific journal, BACKGROUND: Knee osteoarthritis (OA) impairs postural control and may affect how the lower limb joints are used for postural control. OBJECTIVE: To investigate how individuals with knee OA use lower limb joints for static postural control. METHODS: Ten patients with knee OA and thirteen healthy controls performed quiet standing for 30 s. The standard deviation of the center of mass (COM) and lower limb joint motions in the anterior-posterior (AP) and medial-lateral (ML) planes were calculated from three-dimensional marker trajectories. Pearson's correlation analysis and independent t-tests were conducted to investigate the relationship between COM and lower limb joint motion and to compare group difference, respectively. RESULTS: The AP hip angular velocity alone in the knee OA group and the AP hip and knee angular velocity in the control group were significantly correlated with the AP COM velocity. The ML hip angular velocity was significantly correlated with the ML COM velocity in both groups. The knee OA group exhibited a significantly larger standard deviation of AP COM velocity than the control group. CONCLUSIONS: Individuals with knee OA depended solely on the contribution of the hip to the AP COM velocity, which could not be successfully controlled by the knee.
  • The impact of elevated blood lead levels in children on maternal health-related quality of life.
    Hokuto Nakata, Harukazu Tohyama, Wakako Fujita, Shouta M M Nakayama, Mayumi Ishizuka, John Yabe, Nosiku S Munyinda, Doreen Sakala, Kennedy Choongo, Shojiro Yamasaki, Natsumi Nagai, Takahiko Yoshida, Takeshi Saito
    Chemosphere, 279, 130490, 130490, 15 Apr. 2021, [Peer-reviewed], [Corresponding author], [Internationally co-authored], [International Magazine]
    English, Scientific journal, Kabwe is a mining town in Zambia that has been ranked among "the ten most polluted places in the world" with previous findings of serious lead (Pb) pollution. In this study, we aim to examine the impact of childhood Pb poisoning on the health-related quality of life (HRQoL) of mothers in Kabwe. The HRQoL was assessed using the Short-Form 36 survey for 404 mothers coming from residences in 40 randomly selected standard enumeration areas (SEAs). Blood lead levels (BLLs) of the household members including the mothers themselves were measured. We found a significant positive correlation between the BLLs of the mothers and their children (R = 0.6385, p < 0.0001), while the BLLs of preschool-aged and school-aged children were significantly higher than those of their mothers and fathers. Using the data sets containing the BLLs of the household members, the age of the mothers, the household income, and the household SEA, we performed stepwise multiple linear regression analyses. The results showed significant negative associations between the representative BLL of household children and the BLL of preschool-aged children with the vitality and mental health scores of their mothers. Additionally, the BLL of school-aged children was only significantly associated with the mental health score of their mothers. By contrast, there was a significant negative association between the BLLs of the mothers with the social role functioning score. This suggests that elevated BLLs in children have a negative impact on the mental health conditions of their mothers regardless of the mothers' BLL.
  • Association between the wechsler adult intelligence scale III and early return to work after traumatic brain injury.
    Yuki Iida, Haruko Chiba, Satoshi Ikeda, Harukazu Tohyama, Katsunori Ikoma
    Work (Reading, Mass.), 68, 4, 1101, 1111, 08 Apr. 2021, [Peer-reviewed], [International Magazine]
    English, Scientific journal, BACKGROUND: Residual capacity evaluation via neuropsychological testing can facilitate the development of a rehabilitation plan in patients following a traumatic brain injury (TBI). OBJECTIVE: This study aimed to confirm the tasks that patients must perform well for early return to work (RTW) following TBI using the Wechsler Adult Intelligence Scale III (WAIS-III). METHODS: In total, 40 male and 13 female patients who suffered from neurobehavioral disabilities following TBI were recruited and classified into two groups: the successfully returned to work group (SRTW-G; n = 22) and the unsuccessfully returned to work group (USRTW-G; n = 31). The outcomes assessed by WAIS-III and the time to RTW were compared between the SRTW-G and USRTW-G groups. Multiple logistic regression, multiple regression analysis, and Cox regression were employed to assess differences between the groups. RESULTS: The Comprehension and Letter-Number Sequencing subtests of the WAIS-III were significantly correlated with early RTW more than the other subtests. CONCLUSIONS: We found that, as reflected in the two subtests, patients with TBI must be able to perform well in the following tasks for early RTW: retention of information for short time periods, information processing, and social judgment based on the knowledge of the patient's experience.
  • Analysis of 3-D Kinematics Using H-Gait System during Walking on a Lower Body Positive Pressure Treadmill.
    Yoshiaki Kataoka, Ryo Takeda, Shigeru Tadano, Tomoya Ishida, Yuki Saito, Satoshi Osuka, Mina Samukawa, Harukazu Tohyama
    Sensors (Basel, Switzerland), 21, 8, 08 Apr. 2021, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, Recently, treadmills equipped with a lower-body positive-pressure (LBPP) device have been developed to provide precise body weight support (BWS) during walking. Since lower limbs are covered in a waist-high chamber of an LBPP treadmill, a conventional motion analysis using an optical method is impossible to evaluate gait kinematics on LBPP. We have developed a wearable-sensor-based three-dimensional motion analysis system, H-Gait. The purpose of the present study was to investigate the effects of BWS by a LBPP treadmill on gait kinematics using an H-Gait system. Twenty-five healthy subjects walked at 2.5 km/h on a LBPP treadmill under the following three conditions: (1) 0%BWS, (2) 25%BWS and (3) 50%BWS conditions. Acceleration and angular velocity from seven wearable sensors were used to analyze lower limb kinematics during walking. BWS significantly decreased peak angles of hip adduction, knee adduction and ankle dorsiflexion. In particular, the peak knee adduction angle at the 50%BWS significantly decreased compared to at the 25%BWS (p = 0.012) or 0%BWS (p < 0.001). The present study showed that H-Gait system can detect the changes in gait kinematics in response to BWS by a LBPP treadmill and provided a useful clinical application of the H-Gait system to walking exercises.
  • Exercise and pharmacological inhibition of histone deacetylase improves cognitive function accompanied by an increase of gene expressions crucial for neuronal plasticity in the hippocampus.
    Mika Kitahara, Takahiro Inoue, Hiroki Mani, Yasuyuki Takamatsu, Ryo Ikegami, Harukazu Tohyama, Hiroshi Maejima
    Neuroscience letters, 749, 135749, 135749, 01 Apr. 2021, [Peer-reviewed], [International Magazine]
    English, Scientific journal, Exercise is recognized to increase the expression of neurotrophic genes in the hippocampus and prevent cognitive impairment. Histone deacetylase (HDAC) inhibitor acetylate histones and enhance gene transcription in epigenetic regulation. HDAC inhibitors are expected to be an efficacious pharmacological treatment for cognitive function. This study aimed to examine the effect of HDAC inhibitors and exercise on epigenetic markers and neurotrophic gene expression in the hippocampus to find a more enriched brain conditioning for cognitive function based on the synergic effects of pharmacological treatment and behavioral therapy. Thirteen-week-old male mice were divided into four groups. Intraperitoneal administration of an HDAC inhibitor (1.2 g/kg sodium butyrate, NaB) and treadmill exercise (approximately 10 m/min for 60 min) were performed 5 days a week for 4 weeks. NaB administration increased the expression of an immediate-early gene, a neurotrophin, and a neurotrophin receptor in the hippocampus. These results indicate that HDAC inhibition could present an enriched platform for neuronal plasticity in the hippocampus and cognitive function. The novel object recognition test showed that NaB administration increased the score. Notably, the step-through passive avoidance test showed improved learning and memory in the presence of exercise and exercise, indicating that the mice acquired fear memory, specifically in the presence of NaB administration plus exercise. This study found that repetitive administration of HDAC inhibitors improved cognitive function and HDAC inhibitor administration plus exercise has a synergic effect on learning and memory, accompanying the enhancement of crucial gene transcriptions for neuronal plasticity in the hippocampus.
  • Dynamic postural control correlates with activities of daily living and quality of life in patients with knee osteoarthritis.
    Kento Sabashi, Tomoya Ishida, Hisashi Matsumoto, Kentaro Mikami, Takeshi Chiba, Masanori Yamanaka, Yoshimitsu Aoki, Harukazu Tohyama
    BMC musculoskeletal disorders, 22, 1, 287, 287, 18 Mar. 2021, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, BACKGROUND: Knee osteoarthritis (OA) negatively affects dynamic postural control, which is a basic function that individuals use to perform activities of daily living (ADL). The purpose of this study was to investigate the associations of center of pressure (COP) control during the transition from double-leg to single-leg standing with subjective assessments of ADL and quality of life (QOL) in patients with knee OA. METHODS: Thirty-six patients (29 females) with moderate-to-severe knee OA participated. Dynamic postural control was evaluated during the transition from double-leg to single-leg standing. Each patient stood on a force plate, lifted the less affected limb as fast as possible, and maintained single-leg standing with the more affected limb. The COP movements corresponding to anticipatory postural adjustment (APA) and transitional phases were assessed. The maximum displacement and peak velocity of the COP movements in the medial-lateral direction were calculated. The Knee Injury and Osteoarthritis Outcome Score (KOOS) was used for the subjective assessment of ADL and QOL. Pearson's product correlation analysis was performed to investigate the associations of COP movements in the APA and transitional phases with KOOS-ADL and KOOS-QOL. RESULTS: In the APA phase, the maximum COP displacement was significantly correlated with KOOS-ADL (r = -0.353, P = 0.035) and KOOS-QOL (r = -0.379, P = 0.023). In the transitional phase, the maximum COP displacement and peak COP velocity were significantly correlated with KOOS-ADL (maximum displacement: r = 0.352, P = 0.035; peak velocity: r = 0.438, P = 0.008) and with KOOS-QOL (maximum displacement: r = 0.357, P = 0.032; peak velocity: r = 0.343, P = 0.040). CONCLUSIONS: The present study showed that smaller COP movements in the APA phase and smaller and slower COP movements in the transitional phase correlated with poorer ADL and QOL conditions in patients with knee OA. These findings suggest that poor dynamic postural control is associated with poor ADL and QOL conditions in patients with moderate-to-severe medial knee OA. Conservative treatment for patients with knee OA may need to focus on dynamic postural control during the transition from double-leg to single-leg standing.
  • Larger hip external rotation motion is associated with larger knee abduction and internal rotation motions during a drop vertical jump.
    Tomoya Ishida, Yuta Koshino, Masanori Yamanaka, Ryo Ueno, Shohei Taniguchi, Takumi Ino, Satoshi Kasahara, Mina Samukawa, Harukazu Tohyama
    Sports biomechanics, 1, 15, 04 Mar. 2021, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, Associations among hip motions, knee abduction and internal rotation motion during a drop vertical jump (DVJ), which increases the risk of anterior cruciate ligament injury, remain unclear. The purpose of this study was to examine associations among knee abduction, internal rotation and hip joint motions during a DVJ. Fifty-seven young female participants performed a DVJ from a 30-cm height. Hip and knee kinematics and kinetics were analysed using a three-dimensional motion analysis system and force plates. Multiple regression analysis showed that peak knee abduction angle was negatively associated with knee internal rotation and hip internal rotation excursions from initial contact (IC) to peak knee flexion, and positively associated with peak knee abduction moment (R2 = 0.465, P< 0.001). Peak knee internal rotation angle was negatively associated with the hip flexion excursion from IC to peak knee flexion and peak hip adduction moment (R2 = 0.194, P= 0.001). In addition, hip internal rotation excursion was negatively associated with knee abduction and internal rotation excursion from IC to 50 ms after IC. To avoid a large knee abduction and internal rotation motion during jump-landing training, it might be beneficial to provide landing instructions to avoid a large hip external rotation motion.
  • Effects of unweighting on gait kinematics during walking on a lower-body positive-pressure treadmill in patients with hip osteoarthritis.
    Yoshiaki Kataoka, Tomohiro Shimizu, Ryo Takeda, Shigeru Tadano, Yuki Saito, Satoshi Osuka, Tomoya Ishida, Mina Samukawa, Tohru Irie, Daisuke Takahashi, Norimasa Iwasaki, Harukazu Tohyama
    BMC musculoskeletal disorders, 22, 1, 46, 46, Research Square, 08 Jan. 2021, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, BACKGROUND: Hip osteoarthritis (OA) is a musculoskeletal condition that makes walking difficult due to pain induced by weight-bearing activities. Treadmills that support the body weight (BW) reduce the load on the lower limbs, and those equipped with a lower-body positive-pressure (LBPP) device, developed as a new method for unweighting, significantly reduce pain in patients with knee OA. However, the effects of unweighting on gait kinematics remain unclear in patients with hip OA. Therefore, we investigated the effects of unweighting on kinematics in patients with hip OA during walking on a treadmill equipped with an LBPP device. METHODS: A total of 15 women with hip OA and 15 age-matched female controls wore a three-dimensional (3-D) motion analysis system and walked at a self-selected speed on the LBPP treadmill. Data regarding self-reported hip pain using a numeric rating scale (NRS) in which the scores 0 and 10 represented no pain and the worst pain, respectively, under three different BW conditions (100, 75, and 50%) were collected. Moreover, 3-D peak joint angles during gait under each condition were calculated and compared. RESULTS: In the hip OA group, the NRS pain scores at 50 and 75% BW conditions significantly decreased compared with that at 100% BW condition (50%, P = 0.002; 75%, P = 0.026), and the peak hip extension angle decreased compared with that in the healthy controls (P = 0.044). In both groups, unweighting significantly decreased the peak hip (P < 0.001) and knee (P < 0.001) flexion angles and increased the peak ankle plantar flexion angle (P < 0.001) during walking. CONCLUSIONS: Unweighting by the LBPP treadmill decreased pain in the hip OA group but did not drastically alter the gait kinematics compared with that in the control group. Therefore, regarding the use of the LBPP treadmill for patients with hip OA, clinicians should consider the benefits of pain reduction rather than the kinematic changes.
  • Landing Biomechanics During a Single-leg Landing With Lateral Trunk Obliquity in Female Athletes
    Taniguchi S, Ishida T, Yamanaka M, Ueno R, Ikuta R, Chijimatsu M, Samukawa M, Koshino Y, Kasahara S, Tohyama H
    Jan. 2021
    Scientific journal
  • A preliminary study of an ultrasound-based method for measuring talar displacement during the anterior drawer stress test using a Telos device
    Tsutsumi K, Nakaya U, Koshino Y, Tateno M, Matsumoto K, Tanaka M, Yokoyama M, Horie T, Samukawa M, Kamishima T, Tohyama H
    Dec. 2020
    Scientific journal
  • Postural Stability and Muscle Activation Onset during Double- to Single-Leg Stance Transition in Flat-Footed Individuals.
    Yuta Koshino, Mina Samukawa, Shuya Chida, Shinpei Okada, Hirono Tanaka, Kentaro Watanabe, Masato Chijimatsu, Masanori Yamanaka, Harukazu Tohyama
    Journal of sports science & medicine, 19, 4, 662, 669, Dec. 2020, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, The effects of foot posture on postural stability and on muscular activation pattern for postural control remain unclear. This study aimed to investigate postural stability and muscular activation onset during the transition task from double- to single-leg stance in individuals with different foot postures. Twenty-seven healthy men (age: 21.5 ± 1.5 years) were divided into 3 groups using the Foot Posture Index: neutral foot (n = 10); flatfoot (n = 8); and high-arched foot (n = 9). Center of pressure (COP) data and muscle activation onset times of the tibialis anterior, peroneus longus, gastrocnemius medialis, and soleus during the transition task with eyes closed were compared among groups using one-way analysis of variance and a post-hoc Tukey honestly significant difference test (p < 0.05) when the data were normally distributed and the Kruskal-Wallis test and a post-hoc Mann-Whitney U-test with Bonferroni correction (p < 0.0167) when the data were not normally distributed. The COP displacements in the mediolateral and anteroposterior directions and the resultant COP displacement during the first 3 s after a stability time point, as determined by sequential estimation during the single-leg stance phase, differed significantly among the three groups (p < 0.05). Post-hoc tests showed that the displacements were significantly greater in the flatfoot group than in the neutral and high-arched foot groups (p < 0.05), and the effect sizes for these results were large. No muscular activation onset times showed significant intergroup differences. Postural stability was significantly decreased only in the flatfoot group, while muscle activation onsets did not differ significantly by foot posture during the transition task. Decreased postural stability may be one mechanism underlying the link between flatfoot and risk of lower limb injury, and foot posture represents a potential confounder for measuring postural stability during the transition task.
  • Warm-Up Intensity and Time Course Effects on Jump Performance.
    Ryo Tsurubami, Kensuke Oba, Mina Samukawa, Kazuki Takizawa, Itaru Chiba, Masanori Yamanaka, Harukazu Tohyama
    Journal of sports science & medicine, 19, 4, 714, 720, Dec. 2020, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, Jump performance is affected by warm-up intensity and body temperature, but the time course effects have not been thoroughly investigated. The purpose of this study was to investigate time course effects on jump performance after warm-up at different intensities. Nine male athletes (age: 20.9 ± 1.0 years; height: 1.75 ± 0.03 m; weight: 66.4 ± 6.3 kg; mean ± SD) volunteered for this study. The participants performed three warm-ups at different intensities: 15 min at 80% VO2 max, 15 min at 60% VO2 max, and no warm-up (control). After each warm-up, counter movement jump (CMJ) height, vastus lateralis temperature, heart rate and subjective fatigue level were measured at three intervals: immediately after warm-up, 10 min after, and 20 min after, respectively. Significant main effects and interactions were found for muscle temperature (intensity: p < 0.01, η2p = 0.909; time: p < 0.01, η2p = 0.898; interaction: p < 0.01, η2p = 0.917). There was a significant increase of muscle temperature from the baseline after warm-up, which lasted for 20 min after warm-up with 80% VO2 max and 60% VO2 max (p < 0.01). Muscle temperature was significantly higher with warm-up at 80% VO2 max than other conditions (P < 0.01). Significant main effects and interactions for CMJ height were found (intensity: p < 0.01, η2p = 0.762; time: p < 0.01, η2p = 0.810; interaction: p < 0.01, η2p = 0.696). Compared with the control conditions, CMJ height after 80% VO2 max and 60% VO2 max warm-ups were significantly higher (p < 0.01 and p < 0.05, respectively). CMJ height at 20 min after warm-up was significantly higher for 80% VO2 max warm-up than for 60% VO2 max warm-up (p < 0.01). However, CMJ height at 10 min after 60% VO2 max warm-up was not significantly different from the baseline (p < 0.05). These results showed that both high and moderate intensity warm-up can maintain an increase in muscle temperature for 20 min. Jump performance after high-intensity warm-up was increased for 20 min compared to a moderate intensity warm-up.
  • Landing instructions focused on pelvic and trunk lateral tilt decrease the knee abduction moment during a single-leg drop vertical jump.
    Masato Chijimatsu, Tomoya Ishida, Masanori Yamanaka, Shohei Taniguchi, Ryo Ueno, Ryohei Ikuta, Mina Samukawa, Takumi Ino, Satoshi Kasahara, Harukazu Tohyama
    Physical therapy in sport : official journal of the Association of Chartered Physiotherapists in Sports Medicine, 46, 226, 233, Nov. 2020, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, OBJECTIVES: To investigate the effects of pelvic and trunk lateral tilt-focused landing instructions on the knee abduction moment during the single-leg drop vertical jump task. DESIGN: Descriptive laboratory study. SETTING: Motion analysis laboratory. PARTICIPANTS: Fifteen young, healthy female participants. MAIN OUTCOME MEASURES: The participants performed 15 single-leg drop vertical jumps. Landing instructions with self-video recordings were provided so that the participants' pelvis and trunk remained horizontal in the frontal plane. Pelvic, trunk and knee kinematics and kinetics were evaluated using a three-dimensional motion analysis system before and after the landing instructions. RESULTS: The peak knee abduction moment significantly decreased postinstruction (preinstruction 22.6 ± 15.3 Nm, postinstruction 17.9 ± 15.4 Nm, P = 0.004), as did pelvic and trunk lateral tilt (P < 0.01). The knee abduction and internal rotation angles at initial contact significantly decreased postinstruction (P = 0.037, P = 0.007), with no significant change in the peak knee abduction and internal rotation angles from pre-to postinstruction. CONCLUSIONS: Landing instructions focused on pelvic and trunk lateral tilt are effective in decreasing the knee abduction moment during the single-leg drop vertical jump. Pelvic and trunk lateral tilt should be controlled to decrease the knee abduction moment during single-leg landing.
  • Prevalence and characteristics of chronic ankle instability and copers identified by the criteria for research and clinical practice in collegiate athletes.
    Yuta Koshino, Mina Samukawa, Hiromu Murata, Satoshi Osuka, Satoshi Kasahara, Masanori Yamanaka, Harukazu Tohyama
    Physical therapy in sport : official journal of the Association of Chartered Physiotherapists in Sports Medicine, 45, 23, 29, Sep. 2020, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, OBJECTIVES: To investigate the prevalence and characteristics of chronic ankle instability (CAI) and copers among collegiate athletes as identified by criteria for research (CAI-R and copers-R) and for clinical practice (CAI-C and copers-C). DESIGN: Cross-sectional study. SETTING: University. PARTICIPANTS: Collegiate athletes (n = 507). MAIN OUTCOME MEASURES: Participants were assessed by questionnaires based on the International Ankle Consortium guidelines. The percentages of participants with CAI-R, CAI-C, copers-R and copers-C were calculated, respectively. Demographic and injury data were statistically compared between CAI-R and copers-R groups. RESULTS: The data of 470 participants was retained after exclusions. Of these, the prevalence of CAI-R (10.0%) was only half of that of CAI-C (19.8%), and that of copers-R and copers-C was about 5%. Seventy percent of unclassifiable participants had recurrent ankle sprains. CAI was most common in basketball, while copers were less prevalent in basketball, judo, rugby and gymnastics. The age at the initial injury was significantly younger in the CAI-R participants than in the copers-R. CONCLUSIONS: The type of sport and the age at the initial injury may be associated with developing CAI. The standard criteria may not capture the entire clinical CAI population, therefore, care should be taken when applying the research to clinical practice.
  • Rehabilitation Effects after Knee Arthroplasty in a core hospital in the local area in China(和訳中)               
    Jiang Linjing, Kasahara Satoshi, Ishida Tomoya, Shen Liejun, Xu Zhisheng, Jiang Dijin, Wei Yuting, Samukawa Mina, Tohyama Harukazu
    Journal of Asian Rehabilitation Science, 3, 3, 40, 46, アジアリハビリテーション科学学会, Aug. 2020
    English
  • Knee abduction moment is predicted by lower gluteus medius force and larger vertical and lateral ground reaction forces during drop vertical jump in female athletes.
    Ryo Ueno, Alessandro Navacchia, Christopher A DiCesare, Kevin R Ford, Gregory D Myer, Tomoya Ishida, Harukazu Tohyama, Timothy E Hewett
    Journal of biomechanics, 103, 109669, 109669, 16 Apr. 2020, [Peer-reviewed], [Internationally co-authored], [International Magazine]
    English, Scientific journal, Prospective knee abduction moments measured during the drop vertical jump task identify those at increased risk for anterior cruciate ligament injury. The purpose of this study was to determine which muscle forces and frontal plane biomechanical features contribute to large knee abduction moments. Thirteen young female athletes performed three drop vertical jump trials. Subject-specific musculoskeletal models and electromyography-informed simulations were developed to calculate the frontal plane biomechanics and lower limb muscle forces. The relationships between knee abduction moment and frontal plane biomechanics were examined. Knee abduction moment was positively correlated to vertical (R = 0.522, P < 0.001) and lateral ground reaction forces (R = 0.395, P = 0.016), hip adduction angle (R = 0.358, P < 0.023) and lateral pelvic tilt (R = 0.311, P = 0.061). A multiple regression showed that knee abduction moment was predicted by reduced gluteus medius force and increased vertical and lateral ground reaction forces (P < 0.001, R2 = 0.640). Hip adduction is indicative of lateral pelvic shift during landing. The coupled hip adduction and lateral pelvic tilt were associated to the increased vertical and lateral ground reaction forces, propagating into higher knee abduction moments. These biomechanical features are associated with ACL injury and may be limited in a landing with increased activation of the gluteus medius. Targeted neuromuscular training to control the frontal pelvic and hip motion may help to avoid injurious ground reaction forces and consequent knee abduction moment and ACL injury risk.
  • Abdominal draw-in maneuver changes neuromuscular responses to sudden release from trunk loading in patients with non-specific chronic low back pain.
    Satoshi Osuka, Tomoya Ishida, Masanori Yamanaka, Takeshi Chiba, Takuya Miura, Yuta Koshino, Yuki Saito, Akimi Nakata, Mina Samukawa, Satoshi Kasahara, Harukazu Tohyama
    Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 25, 5, 781, 786, 15 Nov. 2019, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, BACKGROUND: Abdominal draw-in maneuver (ADIM) has been recommended to achieve appropriate trunk muscle response for patients with non-specific chronic low back pain (CLBP). However, it has remained unclear whether the intervention with ADIM could change the trunk muscle response to sudden release from loading, which is considered to contribute mechanical circumstances to low back pain. The purpose of the present study was to investigate the effects of the intervention with ADIM on electromyography (EMG) activities of trunk muscles following sudden release from loading. METHODS: Seventeen subjects with non-specific CLBP participated. Subjects resisted trunk flexion or extension loading in semi-seated position, and then the loading was suddenly released. EMG recordings of 6 trunk muscles were acquired using a wireless surface EMG system. Onset and offset times were calculated from the EMG data. The intervention with ADIM was provided for 4 weeks. The onset and offset times were compared between pre- and post-intervention with ADIM. RESULTS: At the post-intervention, the onset of trunk flexors following release from trunk flexion loading became significantly earlier than pre-intervention (P = 0.028). The offset of flexors following release from trunk extension loading of post-intervention was significantly earlier than that of pre-intervention (P = 0.001). CONCLUSIONS: We showed that the intervention with ADIM changed the EMG activity of trunk flexors in response to sudden release from loading. These results suggest a possibility that ADIM might be effective to improve the neuromuscular control of trunk flexors for the treatment of young patients with non-specific CLBP.
  • The onset of deep abdominal muscles activity during tasks with different trunk rotational torques in subjects with non-specific chronic low back pain.
    Satoshi Osuka, Yuta Koshino, Masanori Yamanaka, Takuya Miura, Yuki Saito, Ryo Ueno, Tomoya Ishida, Mina Samukawa, Harukazu Tohyama
    Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 24, 5, 770, 775, Sep. 2019, [Peer-reviewed], [Last author], [Domestic magazines]
    English, Scientific journal, BACKGROUND: Although delayed onset of the deep abdominal muscles activity in subjects with non-specific chronic low back pain (CLBP) has been suggested to be related to trunk rotational torque, no study has examined the onsets associated with non-specific CLBP during a variety of tasks with different trunk rotational torque. The aim of this study is to compare the onsets of deep abdominal muscles activity among tasks with different trunk rotational torques in subjects with and without non-specific CLBP. METHODS: Twelve subjects with non-specific CLBP and 13 control subjects were included. They performed 8 types of upper limb movements. The onsets of muscular activity of bilateral internal oblique-transversus abdominis (IO-TrA) and trunk rotational torque due to the upper limb movements were measured using a surface electromyography and a three-dimensional motion analysis system. RESULTS: In non-specific CLBP group, right IO-TrA activities were significantly delayed during tasks with left trunk rotational torque compared with the control (P < 0.05), while onsets of the left IO-TrA activities were significantly later than those of the control during tasks with right rotational torque of the trunk (P < 0.05). There were no significant differences in onsets of both sides IO-TrA during tasks without trunk rotational torque between non-specific CLBP and control groups (P > 0.05). CONCLUSIONS: The onsets of IO-TrA activities in subjects with non-specific CLBP were delayed during tasks with rotational torque of the trunk in the opposite direction, suggesting a possibility that delayed onset of the deep abdominal muscles during rotational torque of the trunk might be etiology of chronic low back pain.
  • Editorial Commentary: Which Procedure Contributes to Best Outcomes After Arthroscopic Reduction and Minimally Invasive Surgery for Ankle Fractures?
    Harukazu Tohyama
    Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association, 35, 9, 2684, 2685, Sep. 2019, [Peer-reviewed], [Lead author, Corresponding author], [International Magazine]
    English, The algorithm of arthroscopic reduction and minimally invasive surgery (ARMIS) can decrease the incidence of complications and reoperations, in spite of longer operative times and higher doses of irradiation for the patients with a supination-external rotation ankle fracture. At the present time, however, we cannot identify which procedure contributes to improved outcomes with use of the ARMIS algorithm.
  • Forefoot and hindfoot kinematics in subjects with medial tibial stress syndrome during walking and running.
    Takumi Okunuki, Yuta Koshino, Masanori Yamanaka, Kaori Tsutsumi, Masato Igarashi, Mina Samukawa, Hiroshi Saitoh, Harukazu Tohyama
    Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 37, 4, 927, 932, Apr. 2019, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, Excessive foot pronation during static standing, walking and running has been reported as a contributing factor for the development of medial tibial stress syndrome (MTSS). The motion of foot pronation consists of hindfoot and forefoot motion. However, no previous studies have investigated forefoot and hindfoot kinematics during walking and running in subjects with MTSS. The current study sought to compare hindfoot and forefoot kinematics between subjects with and without MTSS while walking and running. Eleven subjects with MTSS and 11 healthy controls (each group containing 10 males and one female) participated in the current study. Segment angles of the hindfoot and forefoot during walking and running barefoot on a treadmill were recorded using three-dimensional kinematic analysis. An independent t-test was used to compare kinematic data between groups. Subjects with MTSS exhibited significantly greater hindfoot eversion and abduction (p < 0.05) during walking and running than subjects without MTSS, significantly greater forefoot eversion and abduction (p < 0.05) during walking, and significantly greater forefoot abduction during running (p < 0.05). Hindfoot and forefoot kinematics during walking and running were significantly different between subjects with and without MTSS. For prevention and rehabilitation of MTSS, it may be important to focus on not only hindfoot but also forefoot kinematics during both running and walking. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res.
  • Development and validation of a culturally relevant Japanese KOOS.
    Lyman S, Omori G, Nakamura N, Takahashi T, Tohyama H, Fukui N, Ikeda H, Sasho T, Saito T, Hayashi Y, Deie M
    Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, Dec. 2018, [Peer-reviewed], [Internationally co-authored]
  • Can arthroscopic Bankart repairs using suture anchors restore equivalent stability to open repairs in the management of traumatic anterior shoulder dislocation? A meta-analysis
    Kazutomo Miura, Eiichi Tsuda, Harukazu Tohyama, Yusuke Iwahori, Tatsuo Mae, Yu Mochizuki, Kohichi Nakagawa, Atsuo Nakamae, Toshiyasu Nakamura, Masato Takao, Sohshi Uchida, Takeshi Muneta, Mitsuo Ochi
    Journal of Orthopaedic Science, 23, 6, 935, 941, Nov. 2018, [Peer-reviewed]
    Scientific journal
  • The effects of a subsequent jump on the knee abduction angle during the early landing phase.
    Ishida T, Koshino Y, Yamanaka M, Ueno R, Taniguchi S, Samukawa M, Saito H, Matsumoto H, Aoki Y, Tohyama H
    BMC musculoskeletal disorders, 19, 1, 379, 379, Oct. 2018, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, BACKGROUND: A double-leg landing with or without a subsequent jump is commonly used to evaluate the neuromuscular control of knee abduction. However, the differences in frontal plane knee biomechanics between landings with and without a subsequent jump are not well known. The purpose of the present study was to investigate the effects of a subsequent jump on knee abduction, including during the early landing phase, in female and male subjects. METHODS: Twenty-one female subjects and 21 male subjects participated. All subjects performed drop landing task (a landing without a subsequent jump) and drop vertical jump task (a landing with a subsequent jump). The subjects landed from a 30-cm height. In drop vertical jump, the subjects also performed a maximum vertical jump immediately after landing. The knee abduction angle and moment were analyzed using a 3D motion analysis system. A two-way analysis of variance (task × time) was performed to examine the effects of a subsequent jump on the knee abduction angle during the early landing phase in female and male subjects. Another two-way analysis of variance (task × sex) was performed to compare peak knee abduction angles and moments. RESULTS: In female subjects, the knee abduction angle was significantly greater during drop vertical jump than during drop landing, as measured 45 to 80 ms after initial contact (P < 0.05). Significant task-dependent effects in the peak knee abduction angle (P = 0.001) and the abduction moment (P = 0.029) were detected. The peak knee abduction angle and the abduction moment were greater during drop vertical jump than during drop landing. CONCLUSIONS: Subsequent jumps cause greater knee abduction during the early landing phase only in female subjects. This finding may relate to the sex discrepancy in non-contact anterior cruciate ligament injuries. Additionally, the presence of a subsequent jump significantly increases the peak knee abduction angle and the peak knee abduction moment during landings. Therefore, compared with a landing task without a subsequent jump (drop landing), a landing task with a subsequent jump (drop vertical jump) may be advantageous for screening for knee abduction control, especially in female athletes.
  • Influence of Constant Torque Stretching at Different Stretching Intensities on Flexibility and Mechanical Properties of Plantar Flexors.
    Oba K, Samukawa M, Nakamura K, Mikami K, Suzumori Y, Ishida Y, Keeler N, Saitoh H, Yamanaka M, Tohyama H
    Journal of strength and conditioning research, 35, 3, 709, 714, Jul. 2018, [Peer-reviewed], [Last author], [International Magazine]
    English, Scientific journal, ABSTRACT: Oba, K, Samukawa, M, Nakamura, K, Mikami, K, Suzumori, Y, Ishida, Y, Keeler, N, Saitoh, H, Yamanaka, M, and Tohyama, H. Influence of constant torque stretching at different stretching intensities on flexibility and mechanical properties of plantar flexors. J Strength Cond Res 35(3): 709-714, 2021-The purpose of this study was to examine the effects of constant torque stretching (CTS) at different stretching intensities on the maximal range of motion (ROM) and muscle-tendon unit (MTU) stiffness of plantar flexors. Fourteen healthy men performed 4 trials of differing stretch intensities: no stretching (control), 50, 75, and 100%. Stretch intensity was defined as maximum passive resistive torque predetermined at a familiarization trial. Each stretch trial consisted of 5 sets of 60-second CTS at the designated stretch intensity. Both maximal ROM and passive resistive torque were assessed during passive dorsiflexion, and MTU stiffness was calculated using the torque-angle curves measured before and after CTS. There were no significant differences in maximal ROM or MTU stiffness at the baseline condition. After the intervention, significantly greater maximal ROM and significantly lower MTU stiffness were observed in the 100% CTS condition than the control condition, whereas there were no significant differences between the submaximal intensity condition (i.e., 50 or 75% intensity) and the control condition. Therefore, our findings suggest that maximal intensity stretching is the most effective approach for improving both flexibility and MTU stiffness with CTS.
  • Coupling motion between rearfoot and hip and knee joints during walking and single-leg landing
    Yuta Koshino, Masanori Yamanaka, Yuya Ezawa, Takumi Okunuki, Tomoya Ishida, Mina Samukawa, Harukazu Tohyama
    JOURNAL OF ELECTROMYOGRAPHY AND KINESIOLOGY, 37, 75, 83, Dec. 2017, [Peer-reviewed], [Last author]
    English, Scientific journal
  • Toe-in Landing Increases the Ankle Inversion Angle and Moment During Single-Leg Landing: Implications in the Prevention of Lateral Ankle Sprains
    Yuta Koshino, Tomoya Ishida, Masanori Yamanaka, Mina Samukawa, Takumi Kobayashi, Harukazu Tohyama
    JOURNAL OF SPORT REHABILITATION, 26, 6, 530, 535, Nov. 2017, [Peer-reviewed], [Last author]
    English, Scientific journal
  • Quadriceps force and anterior tibial force occur obviously later than vertical ground reaction force: a simulation study
    Ryo Ueno, Tomoya Ishida, Masanori Yamanaka, Shohei Taniguchi, Ryohei Ikuta, Mina Samukawa, Hiroshi Saito, Harukazu Tohyama
    BMC MUSCULOSKELETAL DISORDERS, 18, 1, 467, Nov. 2017, [Peer-reviewed], [Last author]
    English, Scientific journal
  • Toe-in Landing Increases the Ankle Inversion Angle and Moment During Single-Leg Landing: Implications in the Prevention of Lateral Ankle Sprains.
    Koshino Y, Ishida T, Yamanaka M, Samukawa M, Kobayashi T, Tohyama H
    J Sport Rehabil. 2017 Nov;26(6):530-535. doi: 10.1123/jsr.2016-0004. Epub 2016 Dec 19., 26, 6, 530, 535, Human Kinetics, Nov. 2017, [Peer-reviewed], [Last author]
    Scientific journal, Context:

    Identifying the foot positions that are vulnerable to lateral ankle sprains is important for injury prevention. The effects of foot position in the transverse plane on ankle biomechanics during landing are unknown.

    Objective:

    To examine the effects of toe-in or toe-out positioning on ankle inversion motion and moment during single-leg landing.

    Design:

    Repeated measures.

    Setting:

    Motion analysis laboratory.

    Participants:

    18 healthy participants (9 men and 9 women).

    Interventions:

    Participants performed single-leg landing trials from a 30-cm high box under 3 conditions: natural landing, foot internally rotated (toe-in), and foot externally rotated (toe-out).

    Main Outcome Measures:

    4 toe-in or toe-out angles were calculated against 4 reference coordinates (laboratory, pelvis, thigh, and shank) in the transverse plane. Ankle inversion angle, angular velocity, and external moment in the 200 ms after initial foot-to-ground contact were compared between the 3 landing conditions.

    Results:

    All toe-in or toe-out angles other than those calculated against the shank were significantly different between each of the 3 landing conditions (P < .001). Ankle inversion angle, angular velocity, and moment were highest during toe-in landings (P < .01), while eversion angle and moment were highest during toe-out landings (P < .001). The effect sizes of these differences were large. Vertical ground reaction forces were not different between the 3 landing conditions (P = .290).

    Conclusions:

    Toe-in or toe-out positioning during single-leg landings impacts on ankle inversion and eversion motion and moment. Athletes could train not to land with the toe-in positioning to prevent lateral ankle sprains.
  • The relationship between the load on the knee joint during walking and the biomechanical characteristics of single-leg standing
    Takeshi Chiba, Masanori Yamanaka, Mina Samukawa, Hiroshi Saito, Kento Sabashi, Harukazu Tohyama
    Journal of Physical Therapy Science, 28, 8, 2199, 2203, Society of Physical Therapy Science (Rigaku Ryoho Kagakugakkai), 01 Aug. 2016, [Peer-reviewed], [Last author]
    English, Scientific journal
  • Kinematics and muscle activities of the lower limb during a side-cutting task in subjects with chronic ankle instability
    Yuta Koshino, Tomoya Ishida, Masanori Yamanaka, Yuya Ezawa, Takumi Okunuki, Takumi Kobayashi, Mina Samukawa, Hiroshi Saito, Harukazu Tohyama
    KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 24, 4, 1071, 1080, Apr. 2016, [Peer-reviewed], [Last author]
    English, Scientific journal
  • Gait characterization for osteoarthritis patients using wearable gait sensors (H-Gait systems)
    Shigeru Tadano, Ryo Takeda, Keita Sasaki, Tadashi Fujisawa, Harukazu Tohyama
    JOURNAL OF BIOMECHANICS, 49, 5, 684, 690, Mar. 2016, [Peer-reviewed], [Last author]
    English, Scientific journal
  • Side-to-side differences of three-dimensional knee kinematics during walking by normal subjects
    Takumi Ino, Yasumitsu Ohkoshi, Tatsunori Maeda, Kensaku Kawakami, Shoji Suzuki, Harukazu Tohyama
    Journal of Physical Therapy Science, 27, 6, 1803, 1807, 30 Jun. 2015, [Peer-reviewed], [Last author]
    English, Scientific journal
  • Does restriction of glenohumeral horizontal adduction reflect posterior capsule thickening of the throwing shoulder?
    Tomonobu Ishigaki, Tomoya Ishida, Mina Samukawa, Hiroshi Saito, Yuya Ezawa, Motoki Hirokawa, Takumi Kato, Makoto Sugawara, Harukazu Tohyama, Masanori Yamanaka
    JOURNAL OF PHYSICAL THERAPY SCIENCE, 27, 5, 1299, 1302, May 2015, [Peer-reviewed]
    English, Scientific journal
  • Comparing trapezius muscle activity in the different planes of shoulder elevation
    Tomonobu Ishigaki, Tomoya Ishida, Mina Samukawa, Hiroshi Saito, Motoki Hirokawa, Yuya Ezawa, Makoto Sugawara, Harukazu Tohyama, Masanori Yamanaka
    JOURNAL OF PHYSICAL THERAPY SCIENCE, 27, 5, 1495, 1497, May 2015, [Peer-reviewed]
    English, Scientific journal
  • Individuals with chronic low back pain do not modulate the level of transversus abdominis muscle contraction across different postures
    Takuya Miura, Masanori Yamanaka, Kengo Ukishiro, Harukazu Tohyama, Hiroshi Saito, Mina Samukawa, Takumi Kobayashi, Takumi Ino, Naoki Takeda
    MANUAL THERAPY, 19, 6, 534, 540, Dec. 2014, [Peer-reviewed]
    English, Scientific journal
  • Drift Removal for Improving the Accuracy of Gait Parameters Using Wearable Sensor Systems
    Ryo Takeda, Giulia Lisco, Tadashi Fujisawa, Laura Gastaldi, Harukazu Tohyama, Shigeru Tadano
    SENSORS, 14, 12, 23230, 23247, Dec. 2014, [Peer-reviewed]
    English, Scientific journal
  • Rehabilitation Exercises to Induce Balanced Scapular Muscle Activity in an Anti-gravity Posture
    Tomonobu Ishigaki, Masanori Yamanaka, Motoki Hirokawa, Keita Tai, Yuya Ezawa, Mina Samukawa, Harukazu Tohyama, Makoto Sugawara
    JOURNAL OF PHYSICAL THERAPY SCIENCE, 26, 12, 1871, 1874, Dec. 2014, [Peer-reviewed]
    English, Scientific journal
  • Effects of culture on PAMPS/PDMAAm double-network gel on chondrogenic differentiation of mouse C3H10T1/2 cells: in vitro experimental study
    Yusuke Inagaki, Nobuto Kitamura, Takayuki Kurokawa, Yasuhito Tanaka, Jian P. Gong, Kazunori Yasuda, Harukazu Tohyama
    BMC MUSCULOSKELETAL DISORDERS, 15, 320, Sep. 2014, [Peer-reviewed], [Last author, Corresponding author]
    English, Scientific journal
  • A novel medial collateral ligament reconstruction procedure using semitendinosus tendon autograft in patients with multiligamentous knee injuries: Clinical outcomes
    Nobuto Kitamura, Munehiro Ogawa, Eiji Kondo, Soichiro Kitayama, Harukazu Tohyama, Kazunori Yasuda
    American Journal of Sports Medicine, 41, 6, 1274, 1281, 2013, [Peer-reviewed]
    English, Scientific journal
  • Biomechanical study of healing of patellar tendon after resection of the central one-third in an adult-mature rabbit model
    Eijiro Maeda, Hitoshi Noguchi, Harukazu Tohyama, Kazunori Yasuda, Kozaburo Hayashi
    BIO-MEDICAL MATERIALS AND ENGINEERING, 23, 3, 173, 181, 2013, [Peer-reviewed]
    English, Scientific journal
  • Evaluation of magnetic resonance imaging and clinical outcome after tissue-engineered cartilage implantation: prospective 6-year follow-up study
    Kobun Takazawa, Nobuo Adachi, Masataka Deie, Goki Kamei, Yuji Uchio, Junji Iwasa, Nobuyuki Kumahashi, Taku Tadenuma, Suguru Kuwata, Kazunori Yasuda, Harukazu Tohyama, Akio Minami, Takeshi Muneta, Shigeo Takahashi, Mitsuo Ochi
    JOURNAL OF ORTHOPAEDIC SCIENCE, 17, 4, 413, 424, Jul. 2012, [Peer-reviewed]
    English, Scientific journal
  • Clinical comparison of two suspensory fixation devices for anatomic double-bundle anterior cruciate ligament reconstruction
    Eiji Kondo, Kazunori Yasuda, Shin Miyatake, Nobuto Kitamura, Harukazu Tohyama, Tomonori Yagi
    KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 20, 7, 1261, 1267, Jul. 2012, [Peer-reviewed]
    English, Scientific journal
  • Biomechanical and Histological Evaluations of the Doubled Semitendinosus Tendon Autograft After Anterior Cruciate Ligament Reconstruction in Sheep
    Eiji Kondo, Kazunori Yasuda, Taro Katsura, Riku Hayashi, Yoshihisa Kotani, Harukazu Tohyama
    AMERICAN JOURNAL OF SPORTS MEDICINE, 40, 2, 315, 324, Feb. 2012, [Peer-reviewed], [Last author]
    English, Scientific journal
  • Gender-Based Differences in Outcome After Anatomic Double-Bundle Anterior Cruciate Ligament Reconstruction With Hamstring Tendon Autografts
    Harukazu Tohyama, Eiji Kondo, Riku Hayashi, Nobuto Kitamura, Kazunori Yasuda
    AMERICAN JOURNAL OF SPORTS MEDICINE, 39, 9, 1849, 1857, Sep. 2011, [Peer-reviewed], [Lead author, Corresponding author]
    English, Scientific journal
  • Impaired fracture healing in macrophage migration inhibitory factor-deficient mice
    T. Kobayashi, S. Onodera, E. Kondo, H. Tohyama, H. Fujiki, A. Yokoyama, K. Yasuda
    OSTEOPOROSIS INTERNATIONAL, 22, 6, 1955, 1965, Jun. 2011
    English, Scientific journal
  • Local Administration of Autologous Synovium-Derived Cells Improve the Structural Properties of Anterior Cruciate Ligament Autograft Reconstruction in Sheep
    Eiji Kondo, Kazunori Yasuda, Taro Katsura, Riku Hayashi, Chinatsu Azuma, Harukazu Tohyama
    AMERICAN JOURNAL OF SPORTS MEDICINE, 39, 5, 999, 1007, May 2011, [Last author]
    English, Scientific journal
  • Deficiency of macrophage migration inhibitory factor gene delays healing of the medial collateral ligament: A biomechanical and biological study
    Soichiro Kitayama, Shin Onodera, Eiji Kondo, Takumi Kobayashi, Shin Miyatake, Nobuto Kitamura, Harukazu Tohyama, Kazunori Yasuda
    JOURNAL OF BIOMECHANICS, 44, 3, 494, 500, Feb. 2011, [Peer-reviewed]
    English, Scientific journal
  • In Vivo Imaging of Particle-Induced Inflammation and Osteolysis in the Calvariae of NF kappa B/Luciferase Transgenic Mice
    Kunihiko Takahashi, Shin Onodera, Harukazu Tohyama, Hyuck Joon Kwon, Ken-ichi Honma, Kazunori Yasuda
    JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, Epub, 2011, [Peer-reviewed]
    English, Scientific journal
  • Effects of maturation on the mechanical properties of regenerated and residual tissues in the rabbit patellar tendon after resection of its central one-third
    Eijiro Maeda, Harukazu Tohyama, Hitoshi Noguchi, Kazunori Yasuda, Kozaburo Hayashi
    CLINICAL BIOMECHANICS, 25, 9, 953, 958, Nov. 2010, [Peer-reviewed]
    English, Scientific journal
  • Anatomic Double-Bundle Anterior Cruciate Ligament Reconstruction
    Kazunori Yasuda, Yoshie Tanabe, Eiji Kondo, Nobuto Kitamura, Harukazu Tohyama
    ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY, 26, 9, S21, S34, Sep. 2010, [Peer-reviewed], [Last author]
    English, Scientific journal
  • Implantation of Autogenous Meniscal Fragments Wrapped With a Fascia Sheath Enhances Fibrocartilage Regeneration In Vivo in a Large Harvest Site Defect
    Yasukazu Kobayashi, Kazunori Yasuda, Eiji Kondo, Taro Katsura, Yoshie Tanabe, Masashi Kimura, Harukazu Tohyama
    AMERICAN JOURNAL OF SPORTS MEDICINE, 38, 4, 740, 748, Apr. 2010, [Peer-reviewed], [Last author]
    English, Scientific journal
  • Biomechanical evaluation of a novel application of a fixation device for bone-tendon-bone graft (EndoButton CL BTB) to soft-tissue grafts in anatomic double-bundle anterior cruciate ligament reconstruction
    Shin Miyatake, Eiji Kondo, Harukazu Tohyama, Nobuto Kitamura, Kazunori Yasuda
    Arthroscopy - Journal of Arthroscopic and Related Surgery, 26, 9, 1226, 1232, W.B. Saunders, 2010, [Peer-reviewed]
    English, Scientific journal
  • Atelocollagen-associated autologous chondrocyte implantation for the repair of chondral defects of the knee: a prospective multicenter clinical trial in Japan.
    Tohyama H, Yasuda K, Minami A, Majima T, Iwasaki N, Muneta T, Sekiya I, Yagishita K, Takahashi S, Kurokouchi K, Uchio Y, Iwasa J, Deie M, Adachi N, Sugawara K, Ochi M
    J Orthop Sci, 14, 5, 579, 588, Sep. 2009, [Peer-reviewed], [Lead author, Corresponding author]
    English, Scientific journal
  • Effects of stress shielding and subsequent restressing on mechanical properties of regenerated and residual tissues in rabbit patellar tendon after resection of its central one-third
    Eijiro Maeda, Hiroyuki Asanuma, Hitoshi Noguchi, Harukazu Tohyama, Kazunori Yasuda, Kozaburo Hayashi
    JOURNAL OF BIOMECHANICS, 42, 11, 1592, 1597, Aug. 2009, [Peer-reviewed]
    English, Scientific journal
  • Revascularization in the tendon graft following anterior cruciate ligament reconstruction of the knee: Its mechanisms and regulation
    Harukazu Tohyama, Toshikazu Yoshikawa, Young-Jin Ju, Kazunori Yasuda
    Chang Gung Medical Journal, 32, 2, 133, 139, Mar. 2009, [Peer-reviewed], [Invited], [Lead author, Corresponding author]
    English
  • A novel DNA vaccine-targeting macrophage migration inhibitory factor improves the survival of mice with sepsis
    S. Tohyama, S. Onodera, H. Tohyama, K. Yasuda, J. Nishihira, Y. Mizue, A. Hamasaka, R. Abe, Y. Koyama
    GENE THERAPY, 15, 23, 1513, 1522, Dec. 2008, [Peer-reviewed]
    English, Scientific journal
  • In vivo local administration of osteogenic protein-1 increases structural properties of the overstretched anterior cruciate ligament with partial midsubstance laceration - A biomechanical study in rabbits
    R. Hayashi, E. Kondo, H. Tohyama, T. Saito, K. Yasuda
    JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, 90B, 10, 1392, 1400, Oct. 2008, [Peer-reviewed]
    English, Scientific journal
  • Simultaneous anterior and posterior cruciate ligament reconstruction in chronic knee instabilities: surgical concepts and clinical outcome
    Riku Hayashi, Nobuto Kitamura, Eiji Kondo, Yuko Anaguchi, Harukazu Tohyama, Kazunori Yasuda
    KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 16, 8, 763, 769, Aug. 2008, [Peer-reviewed]
    English, Scientific journal
  • A Novel Double-Network Hydrogel Induces Spontaneous Articular Cartilage Regeneration In Vivo in A Large Osteochondral Defect
    Kazunori Yasuda, Nobuto Kitamura, Jian Ping Gong, Kazunobu Arakaki, Hyuck Joon Kwon, Shin Onodera, Eiji Kondo, Yong Mei Chen, Takayuki Kurokawa, Yoshie Tanabe, Harukazu Tohyama, Fuminori Kanaya, Yoshihiro Ohmiya, Yoshihito Osada
    Macromolecular Bioscience, 9, 4, 307, 316, Apr. 2008, [Peer-reviewed]
    English, Scientific journal
  • Ex vivo supplementation of TGF-beta1 enhances the fibrous tissue regeneration effect of synovium-derived fibroblast transplantation in a tendon defect: a biomechanical study
    Shoichi Okamoto, Harukazu Tohyama, Eiji Kondo, Yuko Anaguchi, Shin Onodera, Kozaburo Hayashi, Kazunori Yasuda
    KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 16, 3, 333, 339, Mar. 2008, [Peer-reviewed]
    English, Scientific journal
  • Active immunization against macrophage migration inhibitory factor using a novel DNA vaccine prevents ovariectomy-induced bone loss in mice
    Shin Onodera, Shigeki Oshima, Jun Nishihira, Kazunori Yasuda, Harukazu Tohyama, Kazuharu Irie, Yoshikazu Koyama
    VACCINE, 26, 6, 829, 836, Feb. 2008, [Peer-reviewed]
    English, Scientific journal
  • Local administration of interleukin-1 receptor antagonist inhibits deterioration of mechanical properties of the stress-shielded patellar tendon
    Shin Miyatake, Harukazu Tohyama, Eiji Kondo, Taro Katsura, Shin Onodera, Kazunori Yasuda
    JOURNAL OF BIOMECHANICS, 41, 4, 884, 889, 2008, [Peer-reviewed]
    English, Scientific journal
  • The responses of extrinsic fibroblasts infiltrating the devitalised patellar tendon to IL-1 beta are different from those of normal tendon fibroblasts
    H. Tohyama, K. Yasuda, H. Uchida, J. Nishihira
    JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, 89B, 9, 1261, 1267, Sep. 2007, [Peer-reviewed], [Lead author, Corresponding author]
    English, Scientific journal
  • Radiologic evaluation of femoral and tibial tunnels created with the transtibial tunnel technique for Anatomic double-bundle anterior Cruciate ligament reconstruction
    Eiji Kondo, Kazunori Yasuda, Hiroki Ichiyama, Chinatsu Azuma, Harukazu Tohyama
    ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY, 23, 8, 869, 876, Aug. 2007, [Peer-reviewed], [Last author]
    English, Scientific journal
  • A novel DNA vaccine targeting macrophage migration inhibitory factor protects joints from inflammation and destruction in murine models of arthritis
    Shin Onodera, Shigeki Ohshima, Harukazu Tohyama, Kazunori Yasuda, Jun Nishihira, Yoichiro Iwakura, Ikkei Matsuda, Akio Minami, Yoshikazu Koyama
    ARTHRITIS AND RHEUMATISM, 56, 2, 521, 530, Feb. 2007, [Peer-reviewed]
    English, Scientific journal
  • Antibody neutralization of TGF-beta enhances the deterioration of collagen fascicles in a tissue-cultured tendon matrix with ex vivo fibroblast infiltration
    Chinatsu Azuma, Harukazu Tohyama, Hideki Nakamura, Fuminori Kanaya, Kazunori Yasuda
    JOURNAL OF BIOMECHANICS, 40, 10, 2184, 2190, 2007, [Peer-reviewed]
    English, Scientific journal
  • Ex vivo infiltration of fibroblasts into the tendon deteriorates the mechanical properties of tendon fascicles but not those of tendon bundles
    Yasunari Ikema, Harukazu Tohyama, Ei Yamamoto, Fuminori Kanaya, Kazunori Yasuda
    CLINICAL BIOMECHANICS, 22, 1, 120, 126, Jan. 2007, [Peer-reviewed], [Corresponding author]
    English, Scientific journal
  • The tensile properties of collagen fascicles harvested from regenerated and residual tissues in the patellar tendon after removal of the central third
    Eijiro Maeda, Hitoshi Noguchi, Harukazu Tohyama, Kazunori Yasuda, Kozaburo Hayashi
    BIO-MEDICAL MATERIALS AND ENGINEERING, 17, 2, 77, 85, 2007, [Peer-reviewed]
    English, Scientific journal
  • In vivo effects of partial electrothermal shrinkage on mechanical properties of the anterior cruciate ligament in rabbits
    Kondo Eiji, Yasuda Kazunori, Tohyama Harukazu
    Clinical Biomechanics, 22, 9, 1037, 1044, Elsevier Ltd., 2007, [Peer-reviewed]
    English, Background: No studies have been conducted to clarify an in vivo remodeling of the radiofrequency-treated lesion of the anterior cruciate ligament. The purpose was to determine in vivo effects of radiofrequency shrinkage on mechanical properties of the anterior cruciate ligament. Methods: Thirty skeletally mature rabbits were used. In each group, radiofrequency energy set at non-ablative levels was applied to the posterolateral bundle of the anterior cruciate ligament with a bipolar radiofrequency generator. All animals were sacrificed at 0, 6, and 12 weeks after surgery, respectively. In each group, 7 and 3 out of the 10 specimens were used for biomechanical and histological evaluations. Findings: After shrinkage treatment, the anterior–posterior translation of the knee and the length of the posterolateral bundle were significantly reduced immediately after surgery, but that this effect disappeared at 6 weeks. The tensile strength and the tangent modulus of the treated bundle were significantly lower than that of the normal control bundle at each period. In addition, the tensile strength and the tangent modulus measured at 12 weeks were significantly lower than that at 0 week. Histological examination showed granulation-like tissues with numerous plump fibroblasts and inflammatory cells were dominantly found in the midsubstance of the posterolateral bundle at 12 weeks. Interpretations: This result suggested that the anterior cruciate ligament tissue shortened with the radiofrequency treatment is elongated gradually over time. The mechanical properties of the posterolateral bundle of the anterior cruciate ligament reduced by the radiofrequency shrinkage are not restored in vivo, but significantly deteriorated with time.
  • Effects of local administration of vascular endothelial growth factor on mechanical characteristics of the semtendinosus tendon graft after anterior cruciate ligament reconstruction in sheep
    Toshikazu Yoshikawa, Harukazu Tohyama, Taro Katsura, Eiji Kondo, Yoshihisa Kotani, Hideo Matsumoto, Yoshiaki Toyama, Kazunori Yasuda
    AMERICAN JOURNAL OF SPORTS MEDICINE, 34, 12, 1918, 1925, Dec. 2006, [Peer-reviewed], [Corresponding author]
    English, Scientific journal
  • Is the increase in type III collagen of the patellar tendon graft after ligament reconstruction really caused by "ligamentization" of the graft?
    Harukazu Tohyama, Kazunori Yasuda, Hisaya Uchida
    KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 14, 12, 1270, 1277, Dec. 2006, [Peer-reviewed], [Lead author, Corresponding author]
    English, Scientific journal
  • The effect of intraosseous graft length on tendon-bone healing in anterior cruciate ligament reconstruction using flexor tendon
    Shuji Yamazaki, Kazunori Yasuda, Fumihisa Tomita, Akio Minami, Harukazu Tohyama
    KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 14, 11, 1086, 1093, Nov. 2006, [Peer-reviewed], [Last author]
    English, Scientific journal
  • Expression of vascular endothelial growth factor and angiogenesis in patellar tendon grafts in the early phase after anterior cruciate ligament reconstruction
    T. Yoshikawa, H. Tohyama, H. Enomoto, H. Matsumoto, Y. Toyama, K. Yasuda
    KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 14, 9, 804, 810, Sep. 2006, [Peer-reviewed], [Corresponding author]
    English, Scientific journal
  • Transgenic mice overexpressing macrophage migration inhibitory factor (MIF) exhibit high-turnover osteoporosis
    Shin Onodera, Satoshi Sasaki, Shigeki Ohshima, Norio Amizuka, Minqi Li, Nobuyuki Udagawa, Kazuharu Irie, Jun Nishihira, Yoshikazu Koyama, Ayako Shiraishi, Harukazu Tohyama, Kazunori Yasuda
    JOURNAL OF BONE AND MINERAL RESEARCH, 21, 6, 876, 885, Jun. 2006, [Peer-reviewed]
    English, Scientific journal
  • Stabilizing effects of ankle bracing under a combination of inversion and axial compression loading
    H Tohyama, K Yasuda, BD Beynnon, PA Renstrom
    KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY, 14, 4, 373, 378, Apr. 2006, [Peer-reviewed], [Lead author, Corresponding author], [Internationally co-authored], [International Magazine]
    English, Scientific journal
  • Clinical evaluation of anatomic double-bundle anterior cruciate ligament reconstruction procedure using hamstring tendon grafts: Comparisons among 3 different procedures
    K Yasuda, E Kondo, H Ichiyama, Y Tanabe, H Tohyama
    ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY, 22, 3, 240, 251, Mar. 2006, [Peer-reviewed], [Last author]
    English, Scientific journal
  • Effects of local administration of vascular endothelial growth factor on properties of the in situ frozen-thawed anterior cruciate ligament in rabbits
    YJ Ju, H Tohyama, E Kondo, T Yoshikawa, T Muneta, K Shinomiya, K Yasuda
    AMERICAN JOURNAL OF SPORTS MEDICINE, 34, 1, 84, 91, Jan. 2006, [Peer-reviewed], [Corresponding author]
    English, Scientific journal
  • Effects of administration of transforming growth factor (TGF)-beta1 and anti-TGF-beta1 antibody on the mechanical properties of the stress-shielded patellar tendon
    Taro Katsura, Harukazu Tohyama, Eiji Kondo, Nobuto Kitamura, Kazunori Yasuda
    JOURNAL OF BIOMECHANICS, 39, 14, 2566, 2572, 2006, [Peer-reviewed]
    English, Scientific journal
  • Growth kinetics and integrin expression of fibroblasts infiltrating devitalised patellar tendons are different from those of intrinsic fibroblasts
    Y Ikema, H Tohyama, H Nakamura, F Kanaya, K Yasuda
    JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, 87B, 12, 1689, 1693, Dec. 2005, [Peer-reviewed], [Corresponding author]
    English, Scientific journal
  • The effect of transforming growth factor-beta on mechanical properties of the fibrous tissue regenerated in the patellar tendon after resecting the central portion
    Y Anaguchi, K Yasuda, T Majima, H Tohyama, A Minami, K Hayashi
    CLINICAL BIOMECHANICS, 20, 9, 959, 965, Nov. 2005, [Peer-reviewed]
    English, Scientific journal
  • The effect of transforming growth factor-beta 1 on intraosseous healing of flexor tendon autograft replacement of anterior cruciate ligament in dogs
    S Yamazaki, K Yasuda, F Tomita, H Tohyama, A Minami
    ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY, 21, 9, 1034, 1041, Sep. 2005, [Peer-reviewed]
    English, Scientific journal
  • Primary stability of three posterior cruciate ligament reconstruction procedures: A biomechanical in vitro study
    N Kitamura, K Yasuda, H Tohyama, M Yamanaka, Y Tanabe
    ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY, 21, 8, 970, 978, Aug. 2005, [Peer-reviewed]
    English, Scientific journal
  • The effect of cyclic loading on the biomechanical characteristics of the femur-graft-tibia complex after anterior cruciate ligament reconstruction using Bone Mulch (TM) screw/WasherLoc (TM) fixation
    T Kudo, H Tohyama, A Minami, K Yasuda
    CLINICAL BIOMECHANICS, 20, 4, 414, 420, May 2005, [Peer-reviewed], [Corresponding author]
    English, Scientific journal
  • Stress deprivation simultaneously induces over-expression of interleukin-lbeta, tumor necrosis factor-alpha, and transforming growth factor-beta in fibroblasts and mechanical deterioration of the tissue in the patellar tendone
    H Uchida, H Tohyama, K Nagashima, Y Ohba, H Matsumoto, Y Toyama, K Yasuda
    JOURNAL OF BIOMECHANICS, 38, 4, 791, 798, Apr. 2005, [Peer-reviewed], [Corresponding author]
    English, Scientific journal
  • The effect of electrothermal shrinkage on the biomechanical properties of the anterior cruciate ligament: An experimental study
    E Kondo, K Yasuda, N Kitamura, T Kudoh, A Minami, H Tohyama
    ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY, 21, 4, 448, 456, Apr. 2005, [Peer-reviewed], [Last author]
    English, Scientific journal
  • Effects of separate application of three growth factors (TGF-beta1, EGF, and PDGF-BB) on mechanical properties of the in situ frozen-thawed anterior cruciate ligament
    A Nagumo, K Yasuda, H Numazaki, H Azuma, Y Tanabe, S Kikuchi, S Harata, H Tohyama
    CLINICAL BIOMECHANICS, 20, 3, 283, 290, Mar. 2005, [Peer-reviewed], [Last author]
    English, Scientific journal
  • Effects of administration of exogenous growth factors on biomechanical properties of the elongation-type anterior cruciate ligament injury with partial laceration
    E Kondo, K Yasuda, M Yamanaka, A Minami, H Tohyama
    AMERICAN JOURNAL OF SPORTS MEDICINE, 33, 2, 188, 196, Feb. 2005, [Peer-reviewed], [Last author]
    English, Scientific journal
  • Anatomic reconstruction of the anteromedial and posterolateral bundles of the anterior cruciate ligament using hamstring tendon grafts
    K Yasuda, E Kondo, H Ichiyama, N Kitarnura, Y Tanabe, H Tohyarna, A Minami
    ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY, 20, 10, 1015, 1025, Dec. 2004, [Peer-reviewed]
    English, Scientific journal
  • Stress deprivation enhances manganese superoxide dismutase expression in the rat patellar tendon
    N Kitamura, H Tohyama, J Nishihira, M Hatano, M Suzuki, K Yasuda
    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 14, 4, 537, 543, Oct. 2004, [Peer-reviewed], [Corresponding author]
    English, Scientific journal
  • The effect of growth factors on biomechanical properties of the bone-patellar tendon-bone graft after anterior cruciate ligament reconstruction - A canine model study
    K Yasuda, F Tomita, S Yamazaki, A Minami, H Tohyama
    AMERICAN JOURNAL OF SPORTS MEDICINE, 32, 4, 870, 880, Jun. 2004, [Peer-reviewed], [Last author]
    English, Scientific journal
  • Inhibition of joint inflammation and destruction induced by anti-type II collagen antibody/lipopolysaccharide (LPS)-induced arthritis in mice due to deletion of macrophage migration inhibitory factor (MIF)
    H Ichiyama, S Onodera, J Nishihira, T Ishibashi, T Nakayama, A Minami, K Yasuda, H Tohyama
    CYTOKINE, 26, 5, 187, 194, Jun. 2004, [Peer-reviewed], [Last author]
    English, Scientific journal
  • Magnetic resonance imaging in stress fractures and shin splints
    Y Aoki, K Yasuda, H Tohyama, H Ito, A Minami
    CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, 421, 260, 267, Apr. 2004, [Peer-reviewed]
    English, Scientific journal
  • Reduction of initial tension in the in situ frozen anterior cruciate ligament
    S Mikami, K Yasuda, R Katsuragi, Y Aoki, A Minami, H Tohyama
    CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, 419, 207, 213, Feb. 2004, [Peer-reviewed], [Last author]
    English, Scientific journal
  • The effect of cell-based therapy with autologous synovial fibroblasts activated by exogenous TGF-beta 1 on the in situ frozen-thawed anterior cruciate ligament
    T Okuizumi, H Tohyama, E Kondo, K Yasuda
    JOURNAL OF ORTHOPAEDIC SCIENCE, 9, 5, 488, 494, 2004, [Peer-reviewed], [Corresponding author]
    English, Scientific journal
  • Biomechanical evaluation of a newly devised model for the elongation-type anterior cruciate ligament injury with partial laceration and permanent elongation
    E Kondo, K Yasuda, M Yamanaka, A Minami, H Tohyama
    CLINICAL BIOMECHANICS, 18, 10, 942, 949, Dec. 2003, [Peer-reviewed], [Last author]
    English, Scientific journal
  • Biomechanical comparisons of three posterior cruciate ligament reconstruction procedures with load-controlled and displacement-controlled cyclic tests
    N Kitamura, K Yasuda, M Yamanaka, H Tohyama
    AMERICAN JOURNAL OF SPORTS MEDICINE, 31, 6, 907, 914, Nov. 2003, [Peer-reviewed], [Last author]
    English, Scientific journal
  • The changes in mechanical properties of regenerated and residual tissues in the patellar tendon after removal of its central portion
    H Tohyama, K Yasuda, Y Kitamura, E Yamamoto, K Hayashi
    CLINICAL BIOMECHANICS, 18, 8, 765, 772, Oct. 2003, [Peer-reviewed], [Lead author, Corresponding author]
    English, Scientific journal
  • Timing of administration of transforming growth factor-beta and epidermal growth factor influences the effect on material properties of the in situ frozen-thawed anterior cruciate ligament
    H Azuma, K Yasuda, H Tohyama, T Sakai, T Majima, Y Aoki, A Minami
    JOURNAL OF BIOMECHANICS, 36, 3, 373, 381, Mar. 2003, [Peer-reviewed]
    English, Scientific journal
  • Anterior drawer test for acute anterior talofibular ligament injuries of the ankle - How much load should be applied during the test?
    H Tohyama, K Yasuda, Y Ohkoshi, BD Beynnon, PA Renstrom
    AMERICAN JOURNAL OF SPORTS MEDICINE, 31, 2, 226, 232, Mar. 2003, [Peer-reviewed], [Lead author, Corresponding author], [Internationally co-authored]
    English, Scientific journal
  • Implantation sites and fiber diameters affect the rate of degradation in absorbable polydioxanone fibers
    S Kimura, K Yasuda, N Hara, T Sakai, S Mikami, A Minami, H Tohyama
    ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY, 19, 1, 68, 74, Jan. 2003, [Peer-reviewed], [Last author]
    English, Scientific journal
  • Effects of stress deprivation on mechanical properties of the in situ frozen-thawed semitendinosus tendon in rabbits
    N Hara, K Yasuda, S Kimura, T Majima, A Minami, H Tohyama
    CLINICAL BIOMECHANICS, 18, 1, 60, 68, Jan. 2003, [Peer-reviewed], [Last author]
    English, Scientific journal
  • The effect of initial graft tension in anterior cruciate ligament reconstruction on the mechanical behaviors of the femur-graft-tibia complex during cyclic loading
    Hironori Numazaki, Harukazu Tohyama, Hideaki Nakano, Shinichi Kikuchi, Kazunori Yasuda
    American Journal of Sports Medicine, 30, 6, 800, 805, 01 Dec. 2002, [Peer-reviewed], [Corresponding author]
    English, Scientific journal
  • Effects of combined administration of transforming growth factor-beta 1 and epidermal growth factor on properties of the in situ frozen anterior cruciate ligament in rabbits
    T Sakai, K Yasuda, H Tohyama, H Azuma, A Nagumo, T Majima, CB Frank
    JOURNAL OF ORTHOPAEDIC RESEARCH, 20, 6, 1345, 1351, Nov. 2002, [Peer-reviewed], [Internationally co-authored]
    English, Scientific journal
  • The effect of graft-tunnel diameter disparity on Intraosseous healing of the flexor tendon graft in anterior cruciate ligament reconstruction
    S Yamazaki, K Yasuda, F Tomita, A Minami, H Tohyama
    AMERICAN JOURNAL OF SPORTS MEDICINE, 30, 4, 498, 505, Jul. 2002, [Peer-reviewed], [Last author]
    English, Scientific journal
  • The effect of increased stress on the patellar tendon
    H Tohyama, K Yasuda
    JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, 84B, 3, 440, 446, Apr. 2002, [Peer-reviewed], [Lead author, Corresponding author]
    English, Scientific journal
  • Avulsion fracture at the femoral attachment of the anterior cruciate ligament after intercondylar eminence fracture of the tibia
    H Tohyama, K Kutsumi, K Yasuda
    AMERICAN JOURNAL OF SPORTS MEDICINE, 30, 2, 279, 282, Mar. 2002, [Peer-reviewed], [Lead author, Corresponding author]
    English, Scientific journal
  • Comparisons of intraosseous graft healing between the doubled flexor tendon graft and the bone-patellar tendon-bone graft in anterior cruciate ligament reconstruction
    F Tomita, K Yasuda, S Mikami, T Sakai, S Yamazaki, H Tohyama
    ARTHROSCOPY, 17, 5, 461, 476, May 2001, [Peer-reviewed], [Last author]
    English, Scientific journal
  • Extrinsic cell infiltration and revascularization accelerate mechanical deterioration of the patellar tendon after fibroblast necrosis
    H Tohyama, K Yasuda
    JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 122, 6, 594, 599, Dec. 2000, [Peer-reviewed], [Lead author, Corresponding author]
    English, Scientific journal
  • The effects of stress enhancement on the extracellular matrix and fibroblasts in the patellar tendon
    H Tohyama, K Yasuda
    JOURNAL OF BIOMECHANICS, 33, 5, 559, 565, May 2000, [Peer-reviewed], [Lead author, Corresponding author]
    English, Scientific journal
  • Interference screw fixation of doubled flexor tendon graft in anterior cruciate ligament reconstruction - biomechanical evaluation with cyclic elongation
    H Nakano, K Yasuda, H Tohyama, M Yamanaka, T Wada, K Kaneda
    CLINICAL BIOMECHANICS, 15, 3, 188, 195, Mar. 2000, [Peer-reviewed], [Corresponding author]
    English, Scientific journal
  • The effect of cyclic displacement on the biomechanical characteristics of anterior cruciate ligament reconstructions
    M Yamanaka, K Yasuda, H Tohyama, H Nakano, T Wada
    AMERICAN JOURNAL OF SPORTS MEDICINE, 27, 6, 772, 777, Nov. 1999, [Peer-reviewed]
    English, Scientific journal
  • The effect of PCL injury on muscle performance
    K Yasuda, H Tohyama, M Inoue
    JOURNAL OF SPORT REHABILITATION, 8, 4, 322, 332, Nov. 1999, [Peer-reviewed]
    English, Scientific journal
  • Swelling and curling behaviors of articular cartilage
    LA Setton, H Tohyama, VC Mow
    JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 120, 3, 355, 361, Jun. 1998, [Peer-reviewed], [Internationally co-authored]
    English, Scientific journal
  • Significance of graft tension in anterior cruciate ligament reconstruction: Basic background and clinical outcome
    Harukazu Tohyama, Kazunori Yasuda
    Knee Surgery, Sports Traumatology, Arthroscopy, 6, 1, S30, S37, 1998, [Peer-reviewed], [Invited], [Lead author, Corresponding author]
    English, Scientific journal
  • Laxity and flexibility of the ankle following reconstruction with the Chrisman-Snook procedure
    H Tohyama, BD Beynnon, MH Pope, LD Haugh, PA Renstrom
    JOURNAL OF ORTHOPAEDIC RESEARCH, 15, 5, 707, 711, Sep. 1997, [Peer-reviewed], [Lead author], [Internationally co-authored]
    English, Scientific journal
  • The effect of anterior cruciate ligament graft elongation at the time of implantation on the biomechanical behavior of the graft and knee
    H Tohyama, BD Beynnon, RJ Johnson, PA Renstrom, SW Arms
    AMERICAN JOURNAL OF SPORTS MEDICINE, 24, 5, 608, 614, Sep. 1996, [Peer-reviewed], [Lead author], [Internationally co-authored]
    English, Scientific journal
  • BIOMECHANICAL ANALYSIS OF THE ANKLE ANTERIOR DRAWER TEST FOR ANTERIOR TALOFIBULAR LIGAMENT INJURIES
    H TOHYAMA, BD BEYNNON, PA RENSTROM, MJ THEIS, BC FLEMING, MH POPE
    JOURNAL OF ORTHOPAEDIC RESEARCH, 13, 4, 609, 614, Jul. 1995, [Peer-reviewed], [Lead author], [Internationally co-authored]
    English, Scientific journal
  • DETERMINATION OF A ZERO STRAIN REFERENCE FOR THE ANTEROMEDIAL BAND OF THE ANTERIOR CRUCIATE LIGAMENT
    BC FLEMING, BD BEYNNON, H TOHYAMA, RJ JOHNSON, CE NICHOLS, P RENSTROM, MH POPE
    JOURNAL OF ORTHOPAEDIC RESEARCH, 12, 6, 789, 795, Nov. 1994, [Peer-reviewed], [Internationally co-authored]
    English, Scientific journal
  • THE RELATIONSHIP BETWEEN ANTERIOR-POSTERIOR KNEE LAXITY AND THE STRUCTURAL-PROPERTIES OF THE PATELLAR TENDON GRAFT - A STUDY IN CANINES
    BD BEYNNON, RJ JOHNSON, H TOYAMA, PA RENSTROM, SW ARMS, RA FISCHER
    AMERICAN JOURNAL OF SPORTS MEDICINE, 22, 6, 812, 820, Nov. 1994, [Peer-reviewed], [Internationally co-authored], [International Magazine]
    English, Scientific journal
  • Morphometry of the semitendinosus and gracilis tendons with application to anterior cruciate ligament reconstruction
    H. Tohyama, B. D. Beynnon, R. J. Johnson, C. E. Nichols, P. A. Renström
    Knee Surgery, Sports Traumatology, Arthroscopy, 1, 3-4, 143, 147, Springer-Verlag, Sep. 1993, [Peer-reviewed], [Lead author], [Internationally co-authored], [International Magazine]
    English, Scientific journal
  • STRESS-STRAIN CHARACTERISTICS OF INSITU FROZEN AND STRESS-SHIELDED RABBIT PATELLAR TENDON
    H TOHYAMA, K OHNO, N YAMAMOTO, K HAYASHI, K YASUDA, K KANEDA
    CLINICAL BIOMECHANICS, 7, 4, 226, 230, Nov. 1992, [Peer-reviewed], [Lead author, Corresponding author]
    English, Scientific journal
  • Treatment of osteoarthritis of the knee with heel wedges
    H. Tohyama, K. Yasuda, K. Kaneda
    International Orthopaedics, 15, 1, 31, 33, Apr. 1991, [Peer-reviewed], [Lead author, Corresponding author]
    English, Scientific journal
  • MULTIPLE RUPTURES OF FLEXOR TENDONS DUE TO HYPERTROPHIC CHANGE AT THE DISTAL RADIO-ULNAR JOINT - A CASE-REPORT
    A MINAMI, T OGINO, H TOHYAMA
    JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 71A, 2, 300, 305, Feb. 1989, [Peer-reviewed], [Last author]
    English, Scientific journal

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    越野裕太, 石田知也, 渡邊謙太郎, 寒川美奈, 遠山晴一, デサントスポーツ科学(Web), 46, 2025
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    遠山 晴一, 調剤と情報, 30, 5, 660, 664, Apr. 2024
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    石田 知也, 寒川 美奈, 遠山 晴一, 臨床スポーツ医学, 41, 4, 370, 375, Apr. 2024
    (株)文光堂, Japanese
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    佐藤 健人, 遠山 晴一, Loco Cure, 10, 1, 26, 31, Feb. 2024
    (株)先端医学社, Japanese
  • Orthoses for osteoarthritis of the knee
    佐橋健人, 遠山晴一, 運動器リハビリテーション, 35, 4, 2024
  • 膝関節屈曲角度の違いがバランスボールに両足を乗せて行う背臥位ブリッジエクササイズにおける下肢体幹筋活動に与える影響
    三好 航平, 大須賀 聡, 石田 知也, 中田 光海, 遠山 晴一, 運動器リハビリテーション, 34, 3, 274, 278, Oct. 2023
    日本運動器科学会, Japanese
  • ウェアラブルセンサを用いた頭頸部運動評価システムの妥当性の検討
    大須賀 聡, 高畑 雅彦, 武田 量, 石田 知也, 中田 光海, 舘ヶ澤 翔, 三好 航平, 遠山 晴一, 運動器リハビリテーション, 34, 1, 39, 44, Jun. 2023
    日本運動器科学会, Japanese
  • 【変形性膝関節症 最近の治療スタンダード】変形性膝関節症に対する装具療法の作用機序とその有用性
    遠山 晴一, 潟沼 祐希, 佐橋 健人, Orthopaedics, 36, 1, 21, 28, Jan. 2023
    (株)全日本病院出版会, Japanese
  • 足関節靱帯損傷の予防に向けた機能評価 足関節靱帯損傷の再受傷予防のための動作評価
    越野 裕太, 渡邊 謙太郎, 石田 知也, 寒川 美奈, 遠山 晴一, 日本臨床スポーツ医学会誌, 30, 4, S191, S191, Oct. 2022
    (一社)日本臨床スポーツ医学会, Japanese
  • 成長期アスリートにおけるジャンプ着地動作特性の検討
    高木 瑛梨, 寒川 美奈, 石田 知也, 笠原 敏史, 遠山 晴一, 日本臨床スポーツ医学会誌, 30, 4, S222, S222, Oct. 2022
    (一社)日本臨床スポーツ医学会, Japanese
  • 膝前十字靱帯再建術後の両脚スクワット動作における膝関節伸展モーメントの非対称性と骨盤回旋の関連
    石田 知也, 寒川 美奈, 越野 裕太, 井野 拓実, 笠原 敏史, 遠山 晴一, 日本臨床スポーツ医学会誌, 30, 4, S355, S355, Oct. 2022
    (一社)日本臨床スポーツ医学会, Japanese
  • 【ACL損傷・再建術-レビューとアップデート-】ACL再建術後の評価 ACL再建膝に対する運動動作の評価
    石田 知也, 寒川 美奈, 遠山 晴一, 臨床スポーツ医学, 39, 9, 948, 953, Sep. 2022
    (株)文光堂, Japanese
  • 成長期男子アスリートのジャンプ着地動作特性 異なる成長期分類による検討               
    並木 隆浩, 寒川 美奈, 高木 瑛梨, 京谷 直音, 小松崎 美帆, 奈良 銀二, 石田 知也, 笠原 敏史, 遠山 晴一, スポーツ理学療法学, 2, Suppl., OS, 06, 2022
    (一社)日本スポーツ理学療法学会, Japanese
  • スキーブーツ装着による下肢関節間の機能的役割の変化 モーグルスキー選手の競技動作特性 Pilot study               
    井野 拓実, 松本 尚, 伊藤 雄, 伊藤 孔一, 山口 聖太, 武井 侑理, 石田 知也, 遠山 晴一, 寒川 美奈, スポーツ理学療法学, 2, Suppl., PS, 07, 2022
    (一社)日本スポーツ理学療法学会, Japanese
  • ソフトボール競技におけるオーバーヘッドスロー動作が肘関節外反制動機能に与える影響               
    野村 真希, 寒川 美奈, 高橋 由弥, 石田 知也, 笠原 敏史, 遠山 晴一, スポーツ理学療法学, 2, Suppl., PS, 06, 2022
    (一社)日本スポーツ理学療法学会, Japanese
  • 膝前十字靱帯再建術後の大腿四頭筋筋力低下の残存と両脚スクワット動作における膝関節伸展モーメントの非対称性との関連               
    石田 知也, 寒川 美奈, 越野 裕太, 井野 拓実, 笠原 敏文, 遠山 晴一, スポーツ理学療法学, 2, Suppl., PS, 06, 2022
    (一社)日本スポーツ理学療法学会, Japanese
  • 過度な足部回内が骨盤および下肢アライメントに与える影響 異なる膝屈曲角度条件による検討
    千田 周也, 越野 裕太, 山中 正紀, 奥貫 拓実, 寒川 美奈, 遠山 晴一, 日本臨床スポーツ医学会誌, 30, 1, 39, 46, Jan. 2022
    (一社)日本臨床スポーツ医学会, Japanese
  • 慢性足関節不安定症症例における片脚ヒールレイズ中の後足部kinematicsと足底圧中心位置の特徴
    秋元 萌子, 渡邊 謙太郎, 越野 裕太, 川原 大輝, 石田 知也, 寒川 美奈, 笠原 敏史, 遠山 晴一, 日本臨床スポーツ医学会誌, 29, 4, S175, S175, Oct. 2021
    (一社)日本臨床スポーツ医学会, Japanese
  • 体幹へのスタティックストレッチングが女性の自律神経活動と主観的ストレスに与える影響
    菅野 千晶, 寒川 美奈, 石田 知也, 遠山 晴一, 笠原 敏史, 日本臨床スポーツ医学会誌, 29, 4, S196, S196, Oct. 2021
    (一社)日本臨床スポーツ医学会, Japanese
  • 若年者の運動習慣と身体認識誤差についての検討               
    千葉 愛未, 笠原 敏史, 江 林京, 衛 雨亭, 石田 知也, 寒川 美奈, 遠山 晴一, 日本運動療法学会大会抄録集, 46回, 18, 18, Jun. 2021
    日本運動療法学会, Japanese
  • ロコモ度が10m歩行試験における下肢キネマティクスに与える影響の検討
    齋藤 優輝, 片岡 義明, 武田 量, 但野 茂, 石田 知也, 山田 悟史, 大須賀 聡, 遠山 晴一, 運動器リハビリテーション, 32, 1, 55, 55, Apr. 2021
    日本運動器科学会, Japanese
  • Timed up and go testにおける下肢kinematicsによるロコモティブシンドロームのリスク因子の検討
    片岡 義明, 斎藤 優輝, 武田 量, 石田 知也, 但野 茂, 山田 悟史, 大須賀 聡, 遠山 晴一, 運動器リハビリテーション, 32, 1, 78, 78, Apr. 2021
    日本運動器科学会, Japanese
  • AIによる動作解析の精度検証(第2報) AI解析vs人による解析               
    井野 拓実, 寒川 美奈, 遠山 晴一, 石田 知也, 高橋 樹, 和田 直史, 佐藤 洋一郎, 山中 正紀, スポーツ理学療法学, 1, Suppl., OS, 04, 2021
    (一社)日本スポーツ理学療法学会, Japanese
  • 前腕回内屈筋群の筋疲労が肘関節外反制動機能に与える影響               
    高橋 由弥, 寒川 美奈, 奈良 昌哉, 鈴森 雄貴, 石田 知也, 笠原 敏史, 遠山 晴一, スポーツ理学療法学, 1, Suppl., OS, 04, 2021
    (一社)日本スポーツ理学療法学会, Japanese
  • ダイナミックストレッチングにおける対象筋収縮の有無が筋腱伸張性に与える効果の検討               
    京谷 直音, 寒川 美奈, 大場 健祐, 千徳 風真, 石田 知也, 笠原 敏史, 遠山 晴一, スポーツ理学療法学, 1, Suppl., OS, 04, 2021
    (一社)日本スポーツ理学療法学会, Japanese
  • 成長期サッカー選手の身長増加と片脚立位バランス能力について               
    並木 隆浩, 寒川 美奈, 石垣 大輔, 高木 瑛梨, 石田 知也, 笠原 敏史, 遠山 晴一, スポーツ理学療法学, 1, Suppl., OS, 05, 2021
    (一社)日本スポーツ理学療法学会, Japanese
  • 【スポーツ外傷・障害に対するリハビリテーションと装具療法】下肢スポーツ外傷・障害の受傷バイオメカニクスとリスク要因
    石田 知也, 井野 拓実, 越野 裕太, 寒川 美奈, 遠山 晴一, 日本義肢装具学会誌, 37, 1, 11, 18, Jan. 2021
    (一社)日本義肢装具学会, Japanese
  • 頭部外傷患者の復職における展望記憶の就労内容による相違
    飯田 有紀, 千葉 春子, 池田 聡, 遠山 晴一, 生駒 一憲, 北海道リハビリテーション学会雑誌, 44, 3, 7, 2021
    北海道リハビリテーション学会, Japanese
  • 前方および後方からの降段動作が両側膝関節内側負荷に与える影響
    水野 歩, 井野 拓実, 佐橋 健人, 千葉 健, 越野 裕太, 寒川 美奈, 遠山 晴一, 山中 正紀, 理学療法ジャーナル, 54, 10, 1225, 1230, Oct. 2020
    (株)医学書院, Japanese
  • 腸腰筋ストレッチングが胸腰椎・骨盤アライメントへ与える効果の検証
    石田 優子, 寒川 美奈, 大場 健裕, 中村 賢太郎, 片寄 正樹, 山中 正紀, 遠山 晴一, 日本臨床スポーツ医学会誌, 28, 3, 501, 505, Aug. 2020
    (一社)日本臨床スポーツ医学会, Japanese
  • 膝蓋骨脱臼に対する大腿四頭筋浅層を用いた内側膝蓋大腿靱帯再建術の術後臨床成績
    井上 千春, 青木 喜満, 安田 和則, 八木 知徳, 井上 雅之, 近藤 英司, 遠山 晴一, 金子 知, 北海道膝関節研究ネットワーク, 北海道整形災害外科学会雑誌, 62, 1, 70, 76, Aug. 2020
    北海道整形災害外科学会, Japanese
  • 【半月板-Save the Meniscus】半月板の基礎 半月板のバイオメカニクス
    遠山 晴一, 整形・災害外科, 63, 5, 499, 506, Apr. 2020
    金原出版(株), Japanese
  • 【レジデントはどの治療法を選択すればよいのか-日常よく遭遇する疾患-】外傷 前十字靱帯損傷               
    遠山 晴一, 石田 知也, 関節外科, 38, 10月増刊, 159, 166, Oct. 2019, [Invited]
    (株)メジカルビュー社, Japanese
  • 【レジデントはどの治療法を選択すればよいのか-日常よく遭遇する疾患-】外傷 前十字靱帯損傷
    遠山 晴一, 石田 知也, 関節外科, 38, 10月増刊, 159, 166, Oct. 2019
    (株)メジカルビュー社, Japanese
  • 内側・外側ウェッジが走行時の後足部運動と膝・股関節運動に及ぼす影響               
    佐藤 冴香, 奥貫 拓実, 越野 裕太, 山中 正紀, 寒川 美奈, 遠山 晴一, 理学療法学, 46, Suppl.1, 1, 5, Aug. 2019
    (公社)日本理学療法士協会, Japanese
  • 後方からの降段動作が膝関節内側負荷に与える影響               
    水野 歩, 井野 拓実, 佐橋 健人, 千葉 健, 越野 裕太, 山中 正紀, 寒川 美奈, 遠山 晴一, 理学療法学, 46, Suppl.1, 2, 4, Aug. 2019
    (公社)日本理学療法士協会, Japanese
  • 後方からの降段動作が膝関節内側負荷に与える影響               
    水野 歩, 井野 拓実, 佐橋 健人, 千葉 健, 越野 裕太, 山中 正紀, 寒川 美奈, 遠山 晴一, 理学療法学, 46, Suppl.1, 2, O, Aug. 2019
    (公社)日本理学療法士協会, Japanese
  • 【下肢スポーツ外傷・障害を持つアスリートの競技復帰-復帰までの過程と復帰基準-】膝ACL再建術後の再受傷予防のためのリハビリテーション               
    石田 知也, 寒川 美奈, 遠山 晴一, 臨床スポーツ医学, 36, 8, 868, 873, Aug. 2019, [Invited]
    (株)文光堂, Japanese
  • アテロコラーゲンを用いた自家培養軟骨移植の組織学的検討               
    甲斐原 拓真, 近藤 英司, 岩崎 浩司, 小野寺 智洋, 遠山 晴一, 岩崎 倫政, 安田 和則, 日本整形外科スポーツ医学会雑誌, 39, 4, 469, 469, Aug. 2019
    (一社)日本整形外科スポーツ医学会, Japanese
  • 内側・外側ウェッジが走行時の後足部運動と膝・股関節運動に及ぼす影響               
    佐藤 冴香, 奥貫 拓実, 越野 裕太, 山中 正紀, 寒川 美奈, 遠山 晴一, 理学療法学, 46, Suppl.1, 1, M, Aug. 2019
    (公社)日本理学療法士協会, Japanese
  • 携帯装着型歩行解析システム(H-Gait)による平地歩行及び階段昇降時における下肢の3次元姿勢計測               
    武田 量, 大須賀 聡, 遠山 晴一, 但野 茂, 運動器リハビリテーション, 30, 2, 211, 211, Jun. 2019
    日本運動器科学会, Japanese
  • 三次元歩行計測システムH-Gaitによる階段昇降時の下肢kinematics評価
    大須賀 聡, 武田 量, 但野 茂, 山田 悟史, 片岡 義明, 石田 知也, 遠山 晴一, 運動器リハビリテーション, 30, 2, 210, 210, Jun. 2019
    日本運動器科学会, Japanese
  • ロコモティブシンドローム発症の危険因子の定量化のための歩行解析システムの開発
    遠山 晴一, 片岡 義明, 武田 量, 大須賀 聡, 千葉 健, 清水 智弘, 生駒 一憲, 岩崎 倫政, 但野 茂, 運動器リハビリテーション, 30, 2, 123, 123, Jun. 2019
    日本運動器科学会, Japanese
  • ロコモティブシンドローム発症の危険因子の定量化のための歩行解析システムの開発               
    遠山 晴一, 片岡 義明, 武田 量, 大須賀 聡, 千葉 健, 清水 智弘, 生駒 一憲, 岩崎 倫政, 但野 茂, 運動器リハビリテーション, 30, 2, 123, 123, Jun. 2019
    日本運動器科学会, Japanese
  • 三次元歩行計測システムH-Gaitによる階段昇降時の下肢kinematics評価               
    大須賀 聡, 武田 量, 但野 茂, 山田 悟史, 片岡 義明, 石田 知也, 遠山 晴一, 運動器リハビリテーション, 30, 2, 210, 210, Jun. 2019
    日本運動器科学会, Japanese
  • AIによる動作解析 三次元動作解析による妥当性の検証               
    井野 拓実, 寒川 美奈, 遠山 晴一, 石田 知也, 佐藤 洋一郎, JOSKAS, 44, 4, 459, 459, May 2019
    (一社)日本関節鏡・膝・スポーツ整形外科学会, Japanese
  • AIによる動作解析 三次元動作解析による妥当性の検証               
    井野 拓実, 寒川 美奈, 遠山 晴一, 石田 知也, 佐藤 洋一郎, JOSKAS, 44, 4, 459, 459, May 2019
    (一社)日本関節鏡・膝・スポーツ整形外科学会, Japanese
  • 頭部外傷の就業復帰におけるRBMTを用いた職種間での要求される能力の相違の検討               
    飯田 有紀, 生駒 一憲, 遠山 晴一, 池田 聡, 小金丸 聡子, 千葉 春子, 憲 克彦, 松尾 雄一郎, 新明 史江, 安彦 かがり, 井口 大暢, 二宮 慎一郎, 西村 宗一郎, 飛沢 悠伊, The Japanese Journal of Rehabilitation Medicine, 56, 特別号, 2, P3, May 2019
    (公社)日本リハビリテーション医学会, Japanese
  • 超音波装置を用いたストレス荷重時の足関節前方移動距離計測の試み               
    中谷 詩世, 館野 真理, 堀江 達則, 松本 和久, 寒川 美奈, 遠山 晴一, 堤 香織, 超音波検査技術, 44, 2, 277, 277, Apr. 2019, [Peer-reviewed]
    (一社)日本超音波検査学会, Japanese
  • 高校野球選手における投球障害予防に関する認識調査               
    奈良 昌哉, 寒川 美奈, 鈴森 雄貴, 中村 賢太郎, 遠山 晴一, 日本臨床スポーツ医学会誌, 26, 4, S280, S280, Nov. 2018
    (一社)日本臨床スポーツ医学会, Japanese
  • 高校野球選手における投球障害予防に関する認識調査               
    奈良 昌哉, 寒川 美奈, 鈴森 雄貴, 中村 賢太郎, 遠山 晴一, 日本臨床スポーツ医学会誌, 26, 4, S280, S280, Nov. 2018
    (一社)日本臨床スポーツ医学会, Japanese
  • ストレッチングによる足関節背屈可動域の増大が片脚スクワット動作時の下肢kinematicsに与える影響               
    千田 周也, 越野 裕太, 山中 正紀, 寒川 美奈, 遠山 晴一, 日本臨床スポーツ医学会誌, 26, 4, S259, S259, Nov. 2018
    (一社)日本臨床スポーツ医学会, Japanese
  • ストレッチングによる足関節背屈可動域の増大が片脚スクワット動作時の下肢kinematicsに与える影響               
    千田 周也, 越野 裕太, 山中 正紀, 寒川 美奈, 遠山 晴一, 日本臨床スポーツ医学会誌, 26, 4, S259, S259, Nov. 2018
    (一社)日本臨床スポーツ医学会, Japanese
  • 【筋機能II:筋機能障害の理学療法評価の実際】 骨関節疾患による筋機能障害の理学療法評価の実際 変形性膝関節症の場合               
    石田 知也, 井野 拓実, 山中 正紀, 遠山 晴一, 理学療法, 35, 11, 1000, 1007, Nov. 2018, [Invited]
    (株)メディカルプレス, Japanese
  • 【筋機能II:筋機能障害の理学療法評価の実際】骨関節疾患による筋機能障害の理学療法評価の実際 変形性膝関節症の場合
    石田 知也, 井野 拓実, 山中 正紀, 遠山 晴一, 理学療法, 35, 11, 1000, 1007, Nov. 2018
    (株)メディカルプレス, Japanese
  • 関節不安定症のバイオメカニクス 膝前十字靱帯損傷のバイオメカニクス               
    遠山 晴一, 上野 亮, 石田 知也, 寒川 美奈, 日本整形外科学会雑誌, 92, 8, S1623, S1623, Aug. 2018
    (公社)日本整形外科学会, Japanese
  • 高校生バスケットボール選手における膝前十字靱帯損傷の好発時期の検討               
    石田 知也, 松本 尚, 鈴木 信, 井上 千春, 金子 知, 山中 正紀, 寒川 美奈, 遠山 晴一, 青木 喜満, 日本整形外科スポーツ医学会雑誌, 38, 4, 666, 666, Aug. 2018
    (一社)日本整形外科スポーツ医学会, Japanese
  • 関節不安定症のバイオメカニクス 膝前十字靱帯損傷のバイオメカニクス               
    遠山 晴一, 上野 亮, 石田 知也, 寒川 美奈, 日本整形外科学会雑誌, 92, 8, S1623, S1623, Aug. 2018
    (公社)日本整形外科学会, Japanese
  • 片脚着地動作における初期接地時の前額面骨盤傾斜と膝関節最大外反モーメントの関連               
    生田 亮平, 石田 知也, 山中 正紀, 谷口 翔平, 上野 亮, 寒川 美奈, 遠山 晴一, 日本臨床スポーツ医学会誌, 26, 3, 431, 436, Aug. 2018
    (一社)日本臨床スポーツ医学会, Japanese
  • 片脚着地動作における初期接地時の前額面骨盤傾斜と膝関節最大外反モーメントの関連
    生田 亮平, 石田 知也, 山中 正紀, 谷口 翔平, 上野 亮, 寒川 美奈, 遠山 晴一, 日本臨床スポーツ医学会誌, 26, 3, 431, 436, Aug. 2018
    (一社)日本臨床スポーツ医学会, Japanese
  • スポーツ障害に対する保存的治療のエビデンス 膝オーバーユース障害に対する保存的治療のエビデンス
    越野 裕太, 山中 正紀, 寒川 美奈, 遠山 晴一, 日本整形外科学会雑誌, 92, 7, 459, 465, Jul. 2018
    スポーツにおける膝オーバーユース障害に対する保存的治療の効果に関する定性的systematic reviewを行った。PubMed検索により、基準を満たす15編を特定した。Patellofemoral pain syndromeに対するインソールなどの足部装具単独による除痛効果は弱く、足部装具と理学療法の併用による除痛効果は中等度であった。膝蓋腱炎の治療に関して、七つの良質な無作為抽出比較試験(RCT)が大腿四頭筋遠心性強化訓練によって症状が改善したことを明らかにした。保存的治療に失敗した慢性膝蓋腱炎に対する多血小板血漿局所注射の除痛および膝機能改善の効果は一貫して良好であることが明らかとなった。また、中等度の質のRCTにおいて理学療法に抗炎症薬と鎮痛剤を併用した腸脛靱帯炎症例群は抗炎症薬のみを併用した群およびプラセボ群に比し、3~7日後のランニング時の疼痛が有意に改善していた。, (公社)日本整形外科学会, Japanese
  • 体幹および骨盤の側方傾斜に着目した動作指導が片脚drop vertical jump着地時の膝関節外反モーメントに与える影響               
    千々松 雅人, 石田 知也, 山中 正紀, 谷口 翔平, 上野 亮, 遠山 晴一, JOSKAS, 43, 4, 387, 387, May 2018
    (一社)日本関節鏡・膝・スポーツ整形外科学会, Japanese
  • ビデオフィードバックによる指導介入がdrop vertical jumpにおける膝関節生体力学に与える即時効果               
    生田 亮平, 石田 知也, 谷口 翔平, 上野 亮, 佐藤 正裕, 遠山 晴一, 山中 正紀, Journal of Athletic Rehabilitation, 14, 1, 31, 36, Mar. 2018
    スポーツ選手のためのリハビリテーション研究会, Japanese
  • ROC曲線を用いた膝前十字靱帯再建術症例に対する術後早期の膝伸展筋力のカットオフ値の検討
    石田 知也, 松本 尚, 鈴木 信, 山中 正紀, 遠山 晴一, 青木 喜満, 日本整形外科スポーツ医学会雑誌, 38, 1, 74, 78, Mar. 2018
    (一社)日本整形外科スポーツ医学会, Japanese
  • ACL再建術後のプロトコル再考 再建術後2次前十字靱帯損傷予防の見地からの再考               
    石田 知也, 山中 正紀, 寒川 美奈, 松本 尚, 青木 喜満, 遠山 晴一, 日本臨床スポーツ医学会誌, 25, 4, S121, S121, Oct. 2017
    (一社)日本臨床スポーツ医学会, Japanese
  • 足部形態が片脚立位時の姿勢安定性および足関節周囲筋活動に与える影響の検討               
    岡田 慎平, 越野 裕太, 遠山 晴一, 千田 周也, 五十嵐 將斗, 佐藤 冴香, 寒川 美奈, 山中 正紀, 日本臨床スポーツ医学会誌, 25, 4, S218, S218, Oct. 2017
    (一社)日本臨床スポーツ医学会, Japanese
  • 大学スポーツ選手を対象とした慢性足関節不安定症の有病率とその特徴の検討               
    村田 拓陸, 越野 裕太, 遠山 晴一, 佐藤 冴香, 千田 周也, 寒川 美奈, 山中 正紀, 日本臨床スポーツ医学会誌, 25, 4, S218, S218, Oct. 2017
    (一社)日本臨床スポーツ医学会, Japanese
  • 足関節捻挫既往例における慢性足関節不安定症進展例と非進展例の疫学的特徴の相違               
    越野 裕太, 山中 正紀, 村田 拓陸, 佐藤 冴香, 千田 周也, 寒川 美奈, 井上 雅之, 遠山 晴一, 日本臨床スポーツ医学会誌, 25, 4, S251, S251, Oct. 2017
    (一社)日本臨床スポーツ医学会, Japanese
  • 片脚着地後のジャンプ動作が着地時の膝関節外反モーメントに与える影響               
    千々松 雅人, 石田 知也, 山中 正紀, 谷口 翔平, 上野 亮, 寒川 美奈, 遠山 晴一, 日本臨床スポーツ医学会誌, 25, 4, S292, S292, Oct. 2017
    (一社)日本臨床スポーツ医学会, Japanese
  • 【ポイント解説 整形外科診断の基本知識】下肢疾患 膝関節overuse症候群の診断
    遠山 晴一, Orthopaedics, 30, 10, 218, 223, Oct. 2017
    (株)全日本病院出版会, Japanese
  • 自家腱ハイブリッド代用材料を用いた膝靱帯再建術 基礎と臨床               
    近藤 英司, 遠山 晴一, 安田 和則, 岩崎 倫政, 金谷 文則, 日本整形外科スポーツ医学会雑誌, 37, 4, 535, 535, Aug. 2017
    (一社)日本整形外科スポーツ医学会, Japanese
  • 膝軟骨欠損に対する自家培養軟骨細胞移植(JACC)の短期成績               
    甲斐原 拓真, 薮内 康史, 小野寺 智洋, 亀田 敏明, 岩崎 倫政, 近藤 英司, 遠山 晴一, 安田 和則, 北海道整形災害外科学会雑誌, 59, 1, 166, 166, Aug. 2017
    北海道整形災害外科学会, Japanese
  • 膝軟骨欠損に対するアテロコラーゲンを用いた自家培養軟骨移植の短〜中期成績               
    甲斐原 拓真, 近藤 英司, 亀田 敏明, 小野寺 智洋, 薮内 康史, 遠山 晴一, 安田 和則, 岩崎 倫政, JOSKAS, 42, 4, 285, 285, May 2017
    (一社)日本関節鏡・膝・スポーツ整形外科学会, Japanese
  • 歩行中の外的膝内転モーメントと片脚立位移行動作での生体力学的指標との関連               
    千葉 健, 山中 正紀, 寒川 美奈, 齊藤 展士, 由利 真, 堀 弘明, 佐橋 健人, 遠山 晴一, 理学療法学, 44, Suppl.2, O, 2, Apr. 2017
    (一社)日本理学療法学会連合, Japanese
  • 変形膝関節症症例におけるFunctional Reach TestとQOLとの相関性の検討               
    佐橋 健人, 山中 正紀, 千葉 健, 寒川 美奈, 齊藤 展士, 由利 真, 堀 弘明, 遠山 晴一, 理学療法学, 44, Suppl.2, P, 1, Apr. 2017
    (一社)日本理学療法学会連合, Japanese
  • 月経前症候群に対するストレッチング介入効果の検討               
    横山 美翔, 寒川 美奈, 宮崎 未来, 石田 優子, 鈴森 雄貴, 生田 亮平, 奥貫 拓実, 佐橋 健人, 齊藤 展士, 遠山 晴一, 山中 正紀, 理学療法学, 44, Suppl.2, P, 1, Apr. 2017
    (一社)日本理学療法学会連合, Japanese
  • 足部multi-segment modelを用いた歩行時の足部内側縦アーチの動的変化と足部kinematicsの相関性の検討
    奥貫 拓実, 越野 裕太, 山中 正紀, 江沢 侑也, 寒川 美奈, 遠山 晴一, 日本臨床スポーツ医学会誌, 25, 2, 232, 238, Apr. 2017
    (一社)日本臨床スポーツ医学会, Japanese
  • スポーツ障害に対する保存的治療のエビデンス 膝オーバーユース障害に対する保存的治療のエビデンス               
    遠山 晴一, 越野 裕太, 寒川 美奈, 山中 正紀, 日本整形外科学会雑誌, 91, 2, S436, S436, Mar. 2017
    (公社)日本整形外科学会, Japanese
  • 膝軟骨欠損に対するアテロコラーゲンを用いた自家培養軟骨移植の短〜中期成績               
    甲斐原 拓真, 亀田 敏明, 近藤 英司, 小野寺 智洋, 薮内 康史, 遠山 晴一, 安田 和則, 岩崎 倫政, 日本整形外科学会雑誌, 91, 3, S1142, S1142, Mar. 2017
    (公社)日本整形外科学会, Japanese
  • 【膝靱帯損傷-up to date-】病態と評価 膝前十字靱帯損傷の受傷機序に関するバイオメカニクス
    上野 亮, 山中 正紀, 遠山 晴一, 関節外科, 36, 3, 212, 219, Mar. 2017
    (株)メジカルビュー社, Japanese
  • 回復期リハビリテーション病棟に入院し、退院後外来フォローが可能であった骨粗鬆症性椎体骨折連鎖の検討               
    憲 克彦, 金子 明義, 細川 吉博, 池田 聡, 遠山 晴一, 生駒 一憲, Journal of Clinical Rehabilitation, 25, 11, 1125, 1128, Nov. 2016
    回復期リハビリテーション病棟に入院し、退院後外来フォローが可能であった骨粗鬆症性椎体骨折連鎖の影響因子について検討した。その結果、原発性骨粗鬆症女性110名のうち、椎体骨折連鎖なし22例、椎体骨折連鎖あり88例であった。椎体骨折連鎖を認める群ではアルブミン値や骨密度も低値であったが、ロジスティック回帰分析では独立した影響因子は認められなかった。, 医歯薬出版(株), Japanese
  • 超音波画像診断装置を用いたドローインと腹臥位腰部セッティングの体幹筋筋厚変化率の比較
    齋藤 優輝, 山中 正紀, 井野 拓実, 片岡 義明, 寒川 美奈, 遠山 晴一, 日本臨床スポーツ医学会誌, 24, 4, S238, S238, Oct. 2016
    (一社)日本臨床スポーツ医学会, Japanese
  • 後足部と膝および股関節で生じるcoupling motionの検討 動作および関節による比較
    越野 裕太, 山中 正紀, 江沢 侑也, 奥貫 拓実, 石田 知也, 寒川 美奈, 井上 雅之, 遠山 晴一, 日本臨床スポーツ医学会誌, 24, 4, S258, S258, Oct. 2016
    (一社)日本臨床スポーツ医学会, Japanese
  • 膝屈曲位における足部回内が下腿・大腿へ及ぼす影響
    千田 周也, 越野 裕太, 遠山 晴一, 五十嵐 將斗, 奥貫 拓実, 佐藤 冴香, 寒川 美奈, 山中 正紀, 日本臨床スポーツ医学会誌, 24, 4, S320, S320, Oct. 2016
    (一社)日本臨床スポーツ医学会, Japanese
  • 膝複合靱帯損傷の治療2016 膝複合靱帯損傷の受傷メカニズム               
    遠山 晴一, 近藤 英司, 北村 信人, 安田 和則, JOSKAS, 41, 4, 316, 316, Jul. 2016
    (一社)日本関節鏡・膝・スポーツ整形外科学会, Japanese
  • Knee sleeve着用が静止立位における変形性膝関節症症例の重心保持機能に与える影響               
    佐橋 健人, 山中 正紀, 千葉 健, 遠山 晴一, 齊藤 展士, 運動器リハビリテーション, 27, 2, 185, 185, Jun. 2016
    日本運動器科学会, Japanese
  • 回復期リハビリテーション病棟に入院し外来フォローが可能であった骨粗鬆症性椎体骨折連鎖の検討               
    憲 克彦, 金子 明義, 細川 吉博, 池田 聡, 遠山 晴一, 生駒 一憲, The Japanese Journal of Rehabilitation Medicine, JARM2016, I39, I39, Jun. 2016
    (公社)日本リハビリテーション医学会, Japanese
  • ポリオ生存者の体成分分析について               
    松尾 雄一郎, 井口 大暢, 大森 紅己子, 安彦 かがり, 千葉 春子, 磯山 浩孝, 池田 聡, 遠山 晴一, 生駒 一憲, The Japanese Journal of Rehabilitation Medicine, JARM2016, I253, I253, Jun. 2016
    (公社)日本リハビリテーション医学会, Japanese
  • MRIで脳外傷が認められる高次脳機能障害者の就労と神経心理学的検査の関係               
    飯田 有紀, 井口 大暢, 大森 紀巳子, 安彦 かがり, 千葉 春子, 磯山 浩孝, 新明 史江, 松尾 雄一郎, 池田 聡, 遠山 晴一, 生駒 一憲, The Japanese Journal of Rehabilitation Medicine, JARM2016, I3, I3, Jun. 2016
    (公社)日本リハビリテーション医学会, Japanese
  • 脳深部刺激療法(DBS)がパーキンソン病患者の嚥下機能に与える影響               
    千葉 春子, 井口 大暢, 大森 紅己子, 安彦 かがり, 磯山 浩孝, 松尾 雄一郎, 遠山 晴一, 池田 聡, 生駒 一憲, The Japanese Journal of Rehabilitation Medicine, JARM2016, I193, I193, Jun. 2016
    (公社)日本リハビリテーション医学会, Japanese
  • Drop vertical jumpにおけるハムストリングスの着地前筋活動と着地中の膝関節外反角度および外反モーメントとの関係
    生田 亮平, 石田 知也, 山中 正紀, 谷口 翔平, 上野 亮, 越野 裕太, 寒川 美奈, 遠山 晴一, 日本臨床スポーツ医学会誌, 24, 1, 71, 77, Jan. 2016
    (一社)日本臨床スポーツ医学会, Japanese
  • 機能訓練強化型通所介護を利用した障害高齢者において生活空間評価(LSA)に影響を及ぼす因子の検討 身体機能関連評価とアンケート調査から
    憲 克彦, 西向 弘樹, 金子 明義, 細川 吉博, 池田 聡, 遠山 晴一, 生駒 一憲, Journal of Clinical Rehabilitation, 24, 12, 1278, 1283, Dec. 2015
    機能訓練強化型通所介護を1年以上利用した32名(男17名、女15名、平均年齢72.7±7.9歳)を対象とした。運動機能・運動関連能力と生活空間評価(LSA)に加え、アンケートにより生活状態や社会的因子および環境因子を調査した。LSA高値およびLSA低値をその中央値で2群に分け、ロジスティック回帰分析で分析・検討した。LSA高値に対する多変量解析において、LSA総合点では有意な因子は抽出されなかったが、各LSAレベル別分析では町内レベルで「10m歩行速度」が、町外レベルでは「社会的交流」が独立の影響因子として抽出された。, 医歯薬出版(株), Japanese
  • 順調にリハビリテーションを行っていた若年患者に,巨大下肢静脈血栓が見つかった1例               
    井口 大暢, 大森 紅己子, 安彦 かがり, 千葉 春子, 磯山 浩孝, 松尾 雄一郎, 池田 聡, 遠山 晴一, 生駒 一憲, The Japanese Journal of Rehabilitation Medicine, 52, 11, 720, 720, Nov. 2015
    (公社)日本リハビリテーション医学会, Japanese
  • 高血圧を原因としたPosterior reversible encephalopathy syndrome(PRES)により可逆的な嚥下障害をきたした1例               
    千葉 春子, 井口 大暢, 大森 紅己子, 安彦 かがり, 磯山 浩孝, 松尾 雄一郎, 池田 聡, 遠山 晴一, 生駒 一憲, 大澤 恵留美, The Japanese Journal of Rehabilitation Medicine, 52, 11, 721, 721, Nov. 2015
    (公社)日本リハビリテーション医学会, Japanese
  • Drop vertical jumpにおける着地後早期の膝関節外反増加量は着地動作中の膝関節最大外反モーメントと相関する               
    生田 亮平, 石田 知也, 山中 正紀, 谷口 翔平, 上野 亮, 越野 裕太, 寒川 美奈, 遠山 晴一, 日本臨床スポーツ医学会誌, 23, 4, S185, S185, Oct. 2015
    (一社)日本臨床スポーツ医学会, Japanese
  • 片脚スクワット動作における足部kinematicsと股関節kinematicsの相互相関の検討
    越野 裕太, 山中 正紀, 江沢 侑也, 奥貫 拓実, 石田 知也, 寒川 美奈, 井上 雅之, 遠山 晴一, 日本臨床スポーツ医学会誌, 23, 4, S245, S245, Oct. 2015
    (一社)日本臨床スポーツ医学会, Japanese
  • Medial tibial stress syndrome症例におけるトレッドミル走行時の足部kinematicsの特徴(第1報)
    奥貫 拓実, 山中 正紀, 越野 裕太, 五十嵐 将斗, 江沢 侑也, 寒川 美奈, 堤 香織, 遠山 晴一, 日本臨床スポーツ医学会誌, 23, 4, S273, S273, Oct. 2015
    (一社)日本臨床スポーツ医学会, Japanese
  • 【膝関節靱帯損傷の保存療法】膝関節靱帯損傷の基礎 損傷靱帯の修復過程
    片岡 義明, 遠山 晴一, 臨床スポーツ医学, 32, 9, 830, 834, Sep. 2015
    (株)文光堂, Japanese
  • ポリオ後症候群と鑑別を要した黄色靱帯血腫の1例               
    大森 紅己子, 松尾 雄一郎, 井口 大暢, 飯田 有紀, 安彦 かがり, 千葉 春子, 磯山 浩孝, 池田 聡, 遠山 晴一, 生駒 一憲, The Japanese Journal of Rehabilitation Medicine, 52, Suppl., S216, S216, May 2015
    (公社)日本リハビリテーション医学会, Japanese
  • 脳外傷と低酸素脳症による高次脳機能障害の神経心理学的検査の比較               
    飯田 有紀, 井口 大暢, 大森 紅己子, 安彦 かがり, 千葉 春子, 磯山 浩孝, 新明 史江, 松尾 雄一郎, 遠山 晴一, 池田 聡, 生駒 一憲, The Japanese Journal of Rehabilitation Medicine, 52, Suppl., S346, S346, May 2015
    (公社)日本リハビリテーション医学会, Japanese
  • 脳外傷による高次脳機能障害の就労と神経心理学的検査の比較               
    飯田 有紀, 井口 大暢, 大森 紅己子, 安彦 かがり, 千葉 春子, 磯山 浩孝, 新明 史江, 松尾 雄一郎, 遠山 晴一, 池田 聡, 生駒 一憲, The Japanese Journal of Rehabilitation Medicine, 52, Suppl., S351, S351, May 2015
    (公社)日本リハビリテーション医学会, Japanese
  • テロスストレス装置を用いたX線足関節前方引き出しテストにおける性差の検討
    横山 美翔, 寒川 美奈, 堤 香織, 田中 茉衣, 遠山 晴一, 理学療法学, 42, Suppl.2, P1, B, Apr. 2015
    【はじめに,目的】足関節前方引き出しテストは,足関節不安定性評価によく用いられている方法である。しかしながら徒手による前方引き出しテストに関しては信頼性が低い(Lee,2014)という報告もみられることから,臨床ではテロスストレス装置を用いたX線前方引き出しテストも診断に行われている。前方引き出しストレステストは,ストレスを加えながら距骨前方移動量を定量的に計測する検査である。身体構造における性差は,筋横断面積(加賀谷,1998),筋厚(Kubo, 2003),関節弛緩性(Shultz, 2009)などに関して報告されており,性差が存在することが示唆されている。これまで,ストレス負荷時の距骨傾斜角をX線で計測した研究では,健常男女間で結果に差がみられている(Wilkerson, 2000)が,距骨前方引き出しテストにおける性差に関しては報告がみられていない。これまでの身体構造における性差に関する報告から,前方引き出しテストにおいても性差が生じる可能性がある。したがって本研究の目的は,テロスストレス装置を用いたX線足関節前方引き出しテストにおける距骨前方移動量の性差を検討することとした。【方法】対象は,足部に整形外科的及び神経学的既往歴のない男性10名(年齢21.9±0.7歳),女性8名(年齢21.3±0.7歳)の両足部とした。足関節不安定性に関しては,「足関節機能的不安定性の主観的評価法(,1991)」日本語版を用いて聴取した。Karlssonの先行研究に基づき,合計が81ポイント以上の場合,足関節機能的不安定性なしと判断した。X線ストレステスト時の測定位肢位は,検側を下にした側臥位で,股関節及び膝関節軽度屈曲位,足関節中間位とした。テロスストレス装置(Telos Stress Device, Griesheim, Germany)を足部に当て,内果と外果を結ぶ線は検査台に対して垂直とした。テロスストレス装置加圧点は脛骨内果から5cm近位とし,加圧なし(0N)時と最大加圧(120N)時のX線写真を撮影した。得られたX線画像より距骨の前方移動量を,脛骨後縁から距骨の最も近い関節面までを測定した。各画像は3回測定し,その平均値を用いて,最大加圧時と加圧なし時の差を算出した。算出した値を対応のないt検定により解析した。有意水準は5%とした。【結果】足関節不安定性に関する質問紙では,男性(右足99.5点,左足99.5点),女性(右足99.6点,左足99.6点)であり,足関節機能的不安定症の被験者は含まれていないことが示された。X線距骨前方引き出しテスト時の両側における距骨前方移動量は,男性2.5±1.2 cm,女性2.6±1.3 cmであり,差はみられなかった。また,一側下肢毎の検討では,右足で男性2.5±1.2 cm,女性2.9±1.4 cm,左足で男性2.5±1.3cm,女性2.2±1.1cmと,有意差は検出されなかった。【考察】本研究では,テロスストレス装置を用いたX線足関節前方引き出しテストにおいて,性差は検出されなかった。足関節構造の性差については,距骨の傾斜角が男性と比べて女性で大きい(Wilkerson, 2000)こと,及び足関節上方及び内側のスペースが女性より男性で広い(Murphy, 2014)こと等解剖学的性差の存在は示唆されていたが,本研究ではこれらと異なる結果を示した。足関節に限らず靭帯は,男性と比べて女性でより伸張性がみられる(Shultz, 2009)という報告もある。今回,足関節前方引き出し試験において性差はみられなかったため,臨床で本テスト実施時には性差の影響は小さいことが示唆される結果となった。一方,徒手で行われる足関節前方引き出しテストでは,足関節前距腓靭帯損傷の検査として足関節を内反も加えて行われることがある。しかしながら,テロスストレス装置による足関節前方引き出しテストでは,距骨は構造上前方に牽引されるのみである。したがって,ストレス負荷のかけ方によって靭帯の伸張性に性差が生じる可能性もある。また,足関節不安定性評価については被験者の主観でのみ判断されていることや,質問紙の結果から足関節機能的不安定症の被験者は含まれていなかったが,整形外科医による診断は実施していなかったことも,本研究の限界として挙げられる。【理学療法学研究としての意義】身体構造の性差については数多くの研究がされているが,靭帯伸張性に統一した見解は得られていない。本研究により,臨床で行われているテロスストレス装置を用いたX線足関節前方引き出しテストにおいては性差がみられなかったため,本試験においては性差による影響が小さい可能性が示唆された。, (公社)日本理学療法士協会, Japanese
  • 腹横筋と腰部多裂筋の形態学的関連性
    三浦 拓也, 山中 正紀, 森井 康博, 寒川 美奈, 齊藤 展士, 小林 巧, 井野 拓実, 遠山 晴一, 理学療法学, 42, Suppl.2, O, 0511, Apr. 2015
    (公社)日本理学療法士協会, Japanese
  • 【膝スポーツ外傷update】内・外側靱帯損傷に関する最近の知見 自家半腱様筋腱ハイブリッド代用材料を用いた内側側副靱帯再建術
    河口 泰之, 遠山 晴一, 北村 信人, 小野寺 純, 近藤 英司, 安田 和則, 関節外科, 34, 3, 271, 277, Mar. 2015
    (株)メジカルビュー社, Japanese
  • ジストニアにウォークエイド訓練を施行した1例               
    井口 大暢, 生駒 一憲, 池田 聡, 遠山 晴一, 松尾 雄一郎, 磯山 浩孝, 千葉 春子, 安彦 かがり, 飯田 有紀, 大森 紅己子, The Japanese Journal of Rehabilitation Medicine, 52, 1, 69, 69, Jan. 2015
    (公社)日本リハビリテーション医学会, Japanese
  • 被殻出血後のCentral poststroke pain(CPSP)に対して,高頻度磁気刺激で効果があった1例               
    大森 紅己子, 井口 大暢, 飯田 有紀, 安彦 かがり, 千葉 春子, 磯山 浩孝, 松尾 雄一郎, 池田 聡, 遠山 晴一, 生駒 一憲, The Japanese Journal of Rehabilitation Medicine, 52, 1, 69, 69, Jan. 2015
    (公社)日本リハビリテーション医学会, Japanese
  • 3D-CTを用いたポイントクラスター法の誤差検証 体表からの骨ランドマーク同定誤差が膝関節kinematicの算出結果に与える影響               
    井野 拓実, 大角 侑平, 小竹 諭, 上原 桐乃, 矢野 結佳子, 吉田 俊教, 遠山 晴一, 川上 健作, 前田 龍智, 鈴木 航, 今淵 隆誠, 大越 康充, 鈴木 昭二, 北海道整形災害外科学会雑誌, 56, 1, 66, 67, Dec. 2014
    北海道整形災害外科学会, Japanese
  • 【スポーツ選手の半月板損傷-復帰に向けた診療ガイド-】治療総論 半月板損傷におけるバイオメカニクス
    遠山 晴一, 臨床スポーツ医学, 31, 12, 1120, 1124, Dec. 2014
    (株)文光堂, Japanese
  • スタティックストレッチングが筋腱複合体伸張性に与える効果に関する性差の検討               
    横山 美翔, 寒川 美奈, 牟田 奈央, 宮部 瑤子, 山中 正紀, 遠山 晴一, 日本臨床スポーツ医学会誌, 22, 4, S159, S159, Oct. 2014
    (一社)日本臨床スポーツ医学会, Japanese
  • Drop Vertical Jumpにおける着地動作時の股関節内旋が膝関節外反に与える影響               
    石田 知也, 山中 正紀, 谷口 翔平, 越野 裕太, 寒川 美奈, 松本 尚, 青木 喜満, 遠山 晴一, 日本臨床スポーツ医学会誌, 22, 4, S124, S124, Oct. 2014
    (一社)日本臨床スポーツ医学会, Japanese
  • ウォーミングアップがダイナミックストレッチングの筋硬度に対する効果に与える影響               
    寒川 美奈, 宮部 瑤子, 遠山 晴一, 日本臨床スポーツ医学会誌, 22, 4, S160, S160, Oct. 2014
    (一社)日本臨床スポーツ医学会, Japanese
  • 骨盤傾斜が骨盤底筋収縮時の骨盤底挙上へ与える影響               
    牟田 奈央, 寒川 美奈, 横山 美翔, 宮部 瑤子, 山中 正紀, 遠山 晴一, 日本臨床スポーツ医学会誌, 22, 4, S209, S209, Oct. 2014
    (一社)日本臨床スポーツ医学会, Japanese
  • 立位姿勢が骨盤底筋収縮時の骨盤底挙上量へ与える影響               
    宮部 瑤子, 寒川 美奈, 横山 美翔, 遠山 晴一, 日本臨床スポーツ医学会誌, 22, 4, S209, S209, Oct. 2014
    (一社)日本臨床スポーツ医学会, Japanese
  • 慢性足関節不安定性症例における機能的不安定性の重症度が片脚ジャンプ着地時の足関節キネマティクスに与える影響               
    越野 裕太, 山中 正紀, 江沢 侑也, 石田 知也, 寒川 美奈, 井上 雅之, 遠山 晴一, 日本臨床スポーツ医学会誌, 22, 4, S216, S216, Oct. 2014
    (一社)日本臨床スポーツ医学会, Japanese
  • ビデオプログラムによる運動療法の変形性膝関節症に対する長期的効果の検討
    黄 于庭, 遠山 晴一, 運動器リハビリテーション, 25, 3, 272, 278, Oct. 2014
    日本運動器科学会, Japanese
  • Drop vertical jump着地後早期における膝関節外反運動の変化量の検討               
    石田 知也, 山中 正紀, 谷口 翔平, 越野 裕太, 寒川 美奈, 齊藤 展士, 小林 巧, 松本 尚, 青木 喜満, 遠山 晴一, JOSKAS, 39, 4, 411, 411, Jul. 2014
    (一社)日本関節鏡・膝・スポーツ整形外科学会, Japanese
  • A型ボツリヌス毒素抵抗性の痙性斜頸患者でB型ボツリヌス毒素治療を受けた一例               
    松尾 雄一郎, 磯山 浩孝, 安彦 かがり, 遠山 晴一, 大森 紅己子, 千葉 春子, 生駒 一憲, The Japanese Journal of Rehabilitation Medicine, 51, Suppl., S333, S333, May 2014
    (公社)日本リハビリテーション医学会, Japanese
  • 体幹深層筋群の活性化は体幹表層筋群の活動性を減少させるか 慢性腰痛症例での検討
    三浦 拓也, 山中 正紀, 齊藤 展士, 寒川 美奈, 小林 巧, 森井 康博, 遠山 晴一, 理学療法学, 41, 大会特別号2, 1255, 1255, May 2014
    (公社)日本理学療法士協会, Japanese
  • 歩行中の膝関節内転モーメントと片脚立位移行動作における下肢体幹の運動学的挙動の関連性
    千葉 健, 山中 正紀, 遠山 晴一, 斉藤 展士, 小林 巧, 江沢 侑也, 谷口 翔平, 堀 享一, 由利 真, 理学療法学, 41, 大会特別号2, 0697, 0697, May 2014
    (公社)日本理学療法士協会, Japanese
  • Star Excursion Balance Testリーチ時の下肢関節角度、内的モーメントとリーチ距離との関係 前方、後内側、後外側方向の検討
    谷口 翔平, 山中 正紀, 石田 知也, 越野 裕太, 江沢 侑也, 生田 亮平, 寒川 美奈, 齊藤 展士, 小林 巧, 遠山 晴一, 理学療法学, 41, 大会特別号2, 1465, 1465, May 2014
    (公社)日本理学療法士協会, Japanese
  • 慢性足関節不安定性症例における片脚着地動作時の下肢関節運動パターン 主成分分析を用いた検討
    越野 裕太, 山中 正紀, 江沢 侑也, 石田 知也, 小林 巧, 寒川 美奈, 齊藤 展士, 遠山 晴一, 理学療法学, 41, 大会特別号2, 1496, 1496, May 2014
    (公社)日本理学療法士協会, Japanese
  • 立位における適切な肩甲骨周囲筋筋活動比を導く運動方法の検討
    石垣 智恒, 山中 正紀, 廣川 基, 田井 啓太, 遠山 晴一, 理学療法学, 41, 大会特別号2, 1422, 1422, May 2014
    (公社)日本理学療法士協会, Japanese
  • 体幹の回旋運動に対する腹横筋の寄与 健常者と慢性腰痛症例の比較
    三浦 拓也, 山中 正紀, 遠山 晴一, 斎藤 展士, 寒川 美奈, 小林 巧, 武田 直樹, 理学療法科学, 29, 2, 207, 212, Apr. 2014
    (一社)理学療法科学学会, Japanese
  • ジルコニア・セラミックLFA-III人工膝関節の10年以上臨床成績               
    北村 信人, 近藤 英司, 小野寺 純, 河口 泰之, 横田 正司, 遠山 晴一, 安田 和則, 日本整形外科学会雑誌, 88, 3, S613, S613, Mar. 2014
    (公社)日本整形外科学会, Japanese
  • 北海道におけるリハビリテーション科専門医の動向について               
    松尾 雄一郎, 安彦 かがり, 生駒 一憲, 荒畦 実, 千葉 春子, 磯山 浩孝, 遠山 晴一, The Japanese Journal of Rehabilitation Medicine, 51, 2, 152, 152, Feb. 2014
    (公社)日本リハビリテーション医学会, Japanese
  • 【競技復帰を目指した膝関節の術後トレーニング】ACL再建術後のリハビリテーションと注意点
    寒川 美奈, 遠山 晴一, 臨床スポーツ医学, 31, 2, 106, 109, Feb. 2014
    (株)文光堂, Japanese
  • 着地後早期の膝関節外反,内旋運動と下肢関節運動の関係
    石田知也, 山中正紀, 谷口翔平, 宝満健太郎, 越野裕太, 寒川美奈, 齊藤展士, 小林巧, 青木喜満, 遠山晴一, 日本理学療法学術大会(Web), 2013, 0, 439, 439, 2014
    【はじめに,目的】膝前十字靱帯(ACL)損傷はスポーツ外傷のうち最も多く,重篤な外傷の一つである。ACL損傷のうち約70%は非接触型損傷であり,女性は男性に比べ非接触型損傷率が2から8倍高いことから,特に女性のACL損傷予防が重要である。近年,ACL損傷メカニズムの一つに接地直後の急激な膝外反,内旋運動が提唱されており(Kogaら,2010),その様な急激な関節運動を防ぐことはACL損傷予防に繋がると考えられる。しかし,接地直後の急激な膝関節外反,内旋運動を導く要因は明らかとなっていない。本研究の目的は着地後早期の膝関節外反,内旋運動と他の下肢関節運動との関係を検討することである。【方法】対象は過去6か月に整形外科学的既往がない健常女性39名(21.3±1.2歳,160.3±6.1cm,52.3±7.0kg)とした。動作課題は30cm台から着地後直ちに最大垂直跳びを行うDrop vertical jumpとし,台からの着地を解析対象とした。反射マーカーを骨盤および下肢の骨指標,右の大腿,下腿などに合計39個貼付し,赤外線カメラ6台(MotionAnalysis,200Hz)と三次元動作解析装置EvaRT4.3.57(Motion Analysis),床反力計2枚(Kistler,1000Hz)を同期させ記録した。下肢関節角度(股関節屈伸・内外転・内外旋,膝関節屈伸・内外反・内外旋,足関節底背屈・内外反)の算出にはデータ解析ソフトSIMM6.0.2(MusculoGraphics)を用いた。また,下肢関節角度は静止立位時の角度を0°とした。初期接地(IC)を床反力の垂直成分が10N以上となった時点として同定し,IC後50msまでの下肢関節角度変化量を算出した。膝関節内外反および回旋角度変化量とその他の下肢関節角度変化量との間の関係をPearsonの相関係数を用いて検討した(P<0.05)。なお,各被験者データは成功3試行の平均値を用いた。【倫理的配慮,説明と同意】本研究は本学保健科学研究院倫理委員会の承認を得て行った。対象には事前に口頭と書面にて本研究の目的,実験手順,考えられる危険性などについて説明し,十分に理解を得て,参加に同意した者は同意書に署名をし,研究に参加した。【結果】膝関節内外反角度(外反が正)はIC時に-1.3±2.9°,IC後50msでは2.9±4.8°であり,接地後50msまでの角度変化量は4.2±2.6°(範囲:-0.3から11.5°)であった。また,膝関節回旋角度(内旋が正)はIC時に2.5±4.8°,IC後50msでは5.9±5.8°であり,接地後50msまでの角度変化量は3.4±4.3°(-5.0から11.1°)であった。IC後50msまでの股関節回旋角度変化量(内旋が正)は1.2±3.1°(-8.5から6.5°)であり,同時期での膝関節内外反角度変化量(R=0.365,P=0.022),膝関節回旋角度変化量(R=0.471,P=0.002)との間に有意な正の相関関係を認めた。その他に有意な相関関係は認めなかった。【考察】本研究結果から着地直後の股関節回旋運動と膝関節内外反,回旋運動との間に相関関係が示され,着地直後の股関節回旋運動がACL損傷と関連することが示唆された。Elleraら(2008)はACL損傷者で股関節内旋可動域が減少していたと報告しており,本研究結果も股関節外旋運動と膝関節外反,内旋運動の関連を示唆する結果であった。従来,股関節内旋はACL損傷と関連があるとされるdynamic knee valgusやknee-inといった下肢の動的アライメントの要素の一つであり,運動連鎖の観点から膝関節外反や内旋の増大を導くと考えられてきた。しかし,本研究結果からその様な正常な運動連鎖が生じないことにより膝関節の外反,内旋ストレスが増加する可能性が示唆された。【理学療法学研究としての意義】本研究結果は着地動作中の股関節外旋運動を減じる,もしくは内旋運動を引き出すことで膝関節外反,内旋ストレスを減じることが出来る可能性を示唆している。また,先行研究でACL損傷者の股関節内旋可動域の減少が報告されており(Elleraら,2008),股関節内旋可動域制限の改善は着地動作中の正常な運動連鎖を導き,膝関節外反,内旋ストレスの減少に繋がるかもしれない。本研究はスポーツ理学療法分野におけるACL損傷予防,またACL再建術後リハビリテーションの一助となるものと考える。, 公益社団法人 日本理学療法士協会, Japanese
  • 慢性足関節不安定性症例の歩行時における下肢筋活動の主成分分析を用いた検討               
    越野 裕太, 山中 正紀, 江沢 侑也, 石田 知也, 寒川 美奈, 井上 雅之, 遠山 晴一, 日本臨床スポーツ医学会誌, 21, 4, S176, S176, Oct. 2013
    (一社)日本臨床スポーツ医学会, Japanese
  • ストレス負荷超音波撮影法による足関節不安定症の定量的評価の試み               
    堤 香織, 寒川 美奈, 遠山 晴一, 日本臨床スポーツ医学会誌, 21, 4, S178, S178, Oct. 2013, [Peer-reviewed]
    (一社)日本臨床スポーツ医学会, Japanese
  • 超音波装置を用いた足関節に対する前方引き出し負荷と移動距離計測の試み               
    中谷 詩世, 福良 沙霧, 寒川 美奈, 神島 保, 遠山 晴一, 堤 香織, 北海道放射線技術雑誌, 75, 116, 116, Oct. 2013
    (公社)日本放射線技術学会-北海道部会, Japanese
  • 陳旧性内側支持機構不全に対する解剖学的内側側副靱帯浅層再建術の2〜15年臨床成績
    小川 宗宏, 稲垣 有佐, 田中 康仁, 北村 信人, 近藤 英司, 河口 泰之, 甲斐 秀顯, 北山 聡一郎, 横田 正司, 今淵 隆誠, 遠山 晴一, 安田 和則, 北海道整形災害外科学会雑誌, 55, 1, 135, 136, Aug. 2013
    北海道整形災害外科学会, Japanese
  • 複合靱帯損傷患者における自家膝屈筋腱を用いた新しい内側側副靱帯再建術の中期臨床成績               
    北村 信人, 小川 宗宏, 近藤 英司, 北山 聡一郎, 遠山 晴一, 安田 和則, JOSKAS, 38, 4, 350, 350, Jun. 2013
    (一社)日本関節鏡・膝・スポーツ整形外科学会, Japanese
  • 整形外科ナースのためのお悩み相談室 靱帯は、完全に切れていなかったら手術しなくても治りますか?
    遠山 晴一, 黄 于庭, 整形外科看護, 18, 6, 570, 571, Jun. 2013
    (株)メディカ出版, Japanese
  • 高次脳機能障害が後遺したびまん性軸索損傷(DAI)に拡散テンソル画像(DTI)FA-SPMimageを施行した4例               
    安彦 かがり, 千葉 春子, 磯山 浩孝, 浦上 祐司, 松尾 雄一郎, 遠山 晴一, 生駒 一憲, The Japanese Journal of Rehabilitation Medicine, 50, Suppl., S328, S328, May 2013
    (公社)日本リハビリテーション医学会, Japanese
  • 前十字靱帯損傷後の歩行分析 非受傷膝におけるキネマティクスと床反力の変化               
    井野 拓実, 大角 侑平, 小竹 諭, 上原 桐乃, 吉田 俊教, 前田 龍智, 鈴木 航, 大越 康充, 川上 健作, 鈴木 昭二, 遠山 晴一, 北海道整形災害外科学会雑誌, 54, 2, 279, 280, Mar. 2013
    北海道整形災害外科学会, Japanese
  • ジルコニア・セラミックLFA-III人工膝関節の中期臨床成績               
    北村 信人, 近藤 英司, 甲斐 秀顯, 河口 泰之, 横田 正司, 遠山 晴一, 安田 和則, 北海道整形災害外科学会雑誌, 54, 2, 321, 321, Mar. 2013
    北海道整形災害外科学会, Japanese
  • 膝蓋骨の機能
    遠山 晴一, 日本医事新報, 4629, 54, 55, Jan. 2013
    (株)日本医事新報社, Japanese
  • TKAの長期成績 関節リウマチ患者におけるアルミナ・セラミックLFA人工膝関節の15年以上の長期臨床成績               
    北村 信人, 近藤 英司, 甲斐 秀顯, 横田 正司, 遠山 晴一, 安田 和則, 日本人工関節学会誌, 42, 15, 16, Dec. 2012
    後十字靱帯温存型アルミナ・セラミックLFA人工膝関節を用いて人工膝関節置換術を行い、術後15年以上経過した関節リウマチ患者51例70関節(男性8膝、女性62膝、平均58.2歳)を対象に、長期臨床成績について検討した。病期はSteinbrocker分類でstage III:16例、IV:35例であった。最終時に死亡:16例20関節、追跡不能:11例16関節を除く24例34関節を評価対象とした。経過中に緩みによる再置換2例、感染で抜去1例を認め、術後15年累積生存率は94.1%であった。最終時の平均可動域は伸展-0.9度、屈曲116.2度、HSSスコアは平均84.7点、Knee Society Kneeスコアは平均90.1点、Functionスコアは平均62.3点であった。平均設置角度はα角:97.9度、β角:88.7度、γ角:1.7度、δ角:85.0度であり、厚さ1mm以上の骨透亮像を6膝に認め、大腿骨前顆に3膝、脛骨内側に5膝、同外側に2膝、同前方に1膝で骨溶解様変化が認められた。3膝に晩発性関節水腫が認められた。, (一社)日本人工関節学会, Japanese
  • ダイナミックストレッチングの異なるプロトコールが関節可動域や筋力に及ぼす影響               
    坂本 健人, 寒川 美奈, 遠山 晴一, 日本臨床スポーツ医学会誌, 20, 4, S171, S171, Oct. 2012
    (一社)日本臨床スポーツ医学会, Japanese
  • ACL再建術後のスポーツ復帰 現状と課題 ACL再建術後のスポーツ復帰 現状と課題 中高校生スポーツ               
    遠山 晴一, 稲垣 有佐, 近藤 英司, 安田 和則, JOSKAS, 37, 4, 200, 200, Jun. 2012
    (一社)日本関節鏡・膝・スポーツ整形外科学会, Japanese
  • 【膝複合靱帯損傷-手術適応とタイミングをめぐって-】膝関節靱帯修復に関する基礎知識
    遠山 晴一, 臨床スポーツ医学, 29, 5, 493, 498, May 2012
    (株)文光堂, Japanese
  • ACL再断裂膝における経骨孔手技による円柱型骨移植の有用性               
    廣津 匡隆, 北村 信人, 近藤 英司, 甲斐 秀顯, 横田 正司, 今淵 隆誠, 河口 泰之, 松田 英敏, 森 裕之, 吉川 勝久, 福井 孝明, 後藤 佳子, 遠山 晴一, 安田 和則, 北海道整形災害外科学会雑誌, 53, 2, 374, 374, Mar. 2012
    北海道整形災害外科学会, Japanese
  • 変形性膝関節症の手術戦略 高位脛骨骨切り術の手術成績と課題               
    眞島 任史, 安田 和則, 青木 喜満, 遠山 晴一, 日本整形外科学会雑誌, 86, 2, S216, S216, Feb. 2012
    (公社)日本整形外科学会, Japanese
  • 膝前十字靱帯再建術の現状と展開 膝屈筋腱ハイブリッド代用材料を用いる解剖学的二重束前十字靱帯再建術               
    近藤 英司, 北村 信人, 河口 泰之, 遠山 晴一, 安田 和則, 日本整形外科学会雑誌, 86, 2, S220, S220, Feb. 2012
    (公社)日本整形外科学会, Japanese
  • 膝OAに対する高位脛骨骨切り術 膝OAに対する逆V字型高位脛骨骨切り術               
    眞島 任史, 安田 和則, 青木 喜満, 遠山 晴一, 日本関節病学会誌, 30, 3, 248, 248, Oct. 2011
    (一社)日本関節病学会, Japanese
  • 変形性膝関節症の介入研究の短期成績 変形性膝関節症症例に対するDVDプログラムを用いた運動療法の介入効果
    遠山 晴一, 安田 和則, 日本整形外科学会雑誌, 85, 10, 733, 739, Oct. 2011
    (公社)日本整形外科学会, Japanese
  • マクロファージ遊走阻止因子遺伝子の欠損が骨折治癒に与える効果               
    小林 巧, 小野寺 伸, 近藤 英司, 遠山 晴一, 藤木 裕行, 横山 敦郎, 安田 和則, 日本整形外科学会雑誌, 85, 8, S1213, S1213, Aug. 2011
    (公社)日本整形外科学会, Japanese
  • 磁気センサーシステムを用いた膝ACL不全膝のpivot shift現象の無侵襲4次元動作解析 3徒手検査手技の比較               
    横田 正司, 北村 信人, 宮武 慎, 近藤 英司, 北山 聡一郎, 甲斐 秀顕, 今淵 隆盛, 稲垣 有佐, 遠山 晴一, 長宗 高樹, 黒坂 昌弘, 安田 和則, 北海道整形災害外科学会雑誌, 53, 1, 116, 117, Aug. 2011
    北海道整形災害外科学会, Japanese
  • 解剖学的2重束前十字靱帯再建術における異なる2つの移植腱作製方法が臨床成績に与えた影響
    稲垣 有佐, 近藤 英司, 遠山 晴一, 田中 康仁, 安田 和則, 日本臨床スポーツ医学会誌, 19, 3, 466, 472, Aug. 2011
    (一社)日本臨床スポーツ医学会, Japanese
  • 高位脛骨骨切り術の適応と限界 Closed wedge               
    眞島 任史, 安田 和則, 青木 喜満, 遠山 晴一, JOSKAS, 36, 4, 58, 58, Jun. 2011
    (一社)日本関節鏡・膝・スポーツ整形外科学会, Japanese
  • 膝複合靱帯損傷の治療 手術適応と手術時期 膝複合靱帯損傷の治療 急性期の病態 膝関節脱臼を中心に               
    遠山 晴一, 近藤 英司, 北村 信人, 安田 和則, JOSKAS, 36, 4, 299, 299, Jun. 2011
    (一社)日本関節鏡・膝・スポーツ整形外科学会, Japanese
  • スポーツ整形外科 術後リハビリテーション・プログラム(第10回) 下肢のスポーツ損傷 膝重度複合靱帯損傷
    遠山 晴一, 千葉 健, 安田 和則, 臨床スポーツ医学, 28, 6, 661, 668, Jun. 2011
    (株)文光堂, Japanese
  • 皮膚冷刺激が脳卒中症例における下肢運動訓練に与える影響
    憲 克彦, 奥山 真澄, 細川 吉博, 遠山 晴一, 生駒 一憲, 運動療法と物理療法, 22, 1, 49, 54, Jun. 2011
    日本運動器科学会, Japanese
  • 【リハビリテーション医に必要な関節疾患みかたのコツ】スポーツに関連する膝関節疾患
    遠山 晴一, MEDICAL REHABILITATION, 130, 41, 49, Apr. 2011
    (株)全日本病院出版会, Japanese
  • 重度多方向動揺性を伴った変形性膝関節症に対して拘束型人工膝関節置換術にて治療した1例               
    北村 信人, 近藤 英司, 甲斐 秀顯, 北山 総一郎, 横田 正司, 今淵 隆誠, 河口 泰之, 松田 英敏, 森 裕之, 吉川 勝久, 福井 孝明, 小野寺 伸, 遠山 晴一, 安田 和則, 井上 雅之, 北海道整形災害外科学会雑誌, 52, 2, 366, 366, Mar. 2011
    北海道整形災害外科学会, Japanese
  • 解剖学的二重束前十字靱帯再建術の前方回旋不安定性に対する制御効果 三次元電磁気センサーを用いた定量的評価               
    北村 信人, 横田 正司, 近藤 英司, 甲斐 秀顯, 河口 泰之, 北山 聡一郎, 今淵 隆誠, 松田 英敏, 遠山 晴一, 長宗 高樹, 安田 和則, 日本整形外科学会雑誌, 85, 3, S467, S467, Mar. 2011
    (公社)日本整形外科学会, Japanese
  • 大腿四頭筋腱および膝屈筋腱ハイブリッド材料を用いた解剖学的2重束後十字靱帯再建術の1例
    松田 英敏, 近藤 英司, 北村 信人, 甲斐 秀顯, 遠山 晴一, 安田 和則, 北海道整形災害外科学会雑誌, 52, 2, 258, 262, Mar. 2011
    北海道整形災害外科学会, Japanese
  • ジルコニア・セラミックLFA-III人工膝関節の5〜9年臨床成績               
    北村 信人, 北山 聡一郎, 新垣 和伸, 近藤 英司, 遠山 晴一, 安田 和則, 日本人工関節学会誌, 40, 310, 311, Dec. 2010
    当院で1999〜2004年にLFA-III TKAを行い術後5年以上追跡しえた40例48膝の治療成績を報告した。関節可動域は伸展が術前平均-5.6°から術後-0.6°に改善し、屈曲が術前平均124.8°から術後125.8°に改善した。最終観察時のJOAスコアは平均84点、HSSスコアは平均91点であった。経過観察中の有害事象として、大腿骨コンポーネントの弛みのために術後2.6年で再置換を要したものが1例(2.5%)、術後8ヵ月時に転倒して大腿骨顆上骨折を負い骨接合術を要したものが1例(2.5%)あった。最終観察時のコンポーネント設置角度はα角が97.2±2.4°、β角が90.6±1.6°、γ角が4.3±4.3°、δ角が84.9±2.0°であり、概ね良好であった。X線学的評価では、コンポーネント周囲の骨透亮像または骨溶解を脛骨側で7膝(15%)に認め、大腿骨側には認めなかった。, (一社)日本人工関節学会, Japanese
  • 大腿四頭筋腱および膝屈筋腱ハイブリッド材料を用いた解剖学的2重束後十字靱帯再建術の一症例
    松田 英敏, 近藤 英司, 北村 信人, 小野寺 伸, 宮武 慎, 小野寺 純, 甲斐 秀顯, 河口 泰之, 北山 聡一郎, 横田 正司, 今淵 隆誠, 稲垣 有佐, 遠山 晴一, 安田 和則, 北海道整形災害外科学会雑誌, 52, 1, 142, 142, Aug. 2010
    北海道整形災害外科学会, Japanese
  • A case of the instability knee with the paralysis for the poliomyelitis and the cervical myelopathy
    Masashi Yokota, Shin Miyatake, Eiji Kondo, Nobuto Kitamura, Shin Onodera, Harukazu Tohyama, Kazunori Yasuda, Hokkaido Journal of Orthopaedics and Traumatology, 52, 48, 52, 01 Aug. 2010
  • マクロファージ遊走阻止因子遺伝子の欠損が膝内側側副靱帯損傷の治癒に与える影響 生体力学的評価               
    北山 総一郎, 小野寺 伸, 宮武 慎, 近藤 英司, 北村 信人, 安田 和則, 遠山 晴一, 北海道整形災害外科学会雑誌, 52, 1, 99, 100, Aug. 2010
    北海道整形災害外科学会, Japanese
  • 磁気センサーを用いた膝前十字靱帯不全膝の無侵襲3次元動作解析               
    横田 正司, 北村 信人, 宮武 慎, 近藤 英司, 甲斐 秀顯, 小川 宗弘, 北山 聡一郎, 今淵 隆誠, 遠山 晴一, 安田 和則, 長宗 高樹, 黒坂 昌弘, 北海道整形災害外科学会雑誌, 52, 1, 127, 127, Aug. 2010
    北海道整形災害外科学会, Japanese
  • ポリオによる麻痺および頸髄症を伴う動揺膝の1例
    横田 正司, 宮武 慎, 近藤 英司, 北村 信人, 小野寺 伸, 遠山 晴一, 安田 和則, 北海道整形災害外科学会雑誌, 52, 1, 48, 52, Aug. 2010
    北海道整形災害外科学会, Japanese
  • 膝ACL不全膝におけるpivot shift現象のin vivo 4次元動作解析 磁気センサーを用いた3徒手検査手技の比較               
    横田 正司, 北村 信人, 宮武 慎, 近藤 英司, 遠山 晴一, 長宗 高樹, 黒坂 昌弘, 安田 和則, JOSKAS, 35, 4, 9, 9, Jun. 2010
    (一社)日本関節鏡・膝・スポーツ整形外科学会, Japanese
  • 複合膝靱帯損傷に対して膝屈筋腱-ハイブリッド代用材料を用いた解剖学的内側側副靱帯浅層再建術の臨床成績               
    小川 宗宏, 北村 信人, 近藤 英司, 北山 聡一郎, 稲垣 有佐, 遠山 晴一, 田中 康仁, 安田 和則, JOSKAS, 35, 4, 216, 216, Jun. 2010
    (一社)日本関節鏡・膝・スポーツ整形外科学会, Japanese
  • 【整形外科ナース必携 見てまなぶ整形外科看護スタンダードテキスト 下肢編】膝関節・下腿 手術と看護 膝の靱帯再建術と看護               
    伊藤 崇倫, 遠山 晴一, 安田 和則, 整形外科看護, 2010春季増刊, 169, 177, May 2010
    (株)メディカ出版, Japanese
  • 解剖学的二重束前十字靱帯再建術における移植腱の最適な固定肢位の決定に関する研究               
    近藤 英司, 北村 信人, 宮武 慎, 小野寺 伸, 甲斐 秀顯, 今淵 隆誠, 小野寺 純, 北山 聡一郎, 横田 正司, 遠山 晴一, 安田 和則, 日本整形外科学会雑誌, 84, 4, S650, S650, Apr. 2010
    (公社)日本整形外科学会, Japanese
  • 膝屈筋腱-ハイブリッド代用材料を用いた解剖学的二重束前十字靱帯再建術の5-8年臨床成績               
    北山 聡一郎, 北村 信人, 近藤 英司, 宮武 慎, 横田 正司, 甲斐 秀顯, 今淵 隆誠, 遠山 晴一, 安田 和則, 日本整形外科学会雑誌, 84, 4, S652, S652, Apr. 2010
    (公社)日本整形外科学会, Japanese
  • 重度複合膝靱帯損傷に対する半腱様筋腱 ハイブリッド代用材料を用いた解剖学的内側側副靱帯浅層再建術の短-長期臨床成績               
    小川 宗宏, 北村 信人, 近藤 英司, 北山 聡一郎, 宮武 慎, 甲斐 秀顯, 横田 正司, 今淵 隆誠, 遠山 晴一, 田中 康仁, 安田 和則, 日本整形外科学会雑誌, 84, 4, S739, S739, Apr. 2010
    (公社)日本整形外科学会, Japanese
  • 膝蓋腱および半腱様筋腱を用いた解剖学的2重束前十字靱帯再建術の一例
    今淵 隆誠, 近藤 英司, 北村 信人, 小野寺 伸, 宮武 慎, 小野寺 純, 甲斐 秀顯, 北山 聡一郎, 横田 正司, 松田 英敏, 稲垣 有佐, 遠山 晴一, 安田 和則, 北海道整形災害外科学会雑誌, 51, 2, 300, 301, Mar. 2010
    北海道整形災害外科学会, Japanese
  • 解剖学的2重束前十字靱帯再建術後におけるX線学的骨孔径の評価               
    河口 泰之, 北村 信人, 近藤 英司, 横田 正司, 北山 聡一郎, 新垣 和伸, 小川 宗宏, 今淵 隆誠, 甲斐 秀顯, 宮武 慎, 小野寺 伸, 遠山 晴一, 安田 和則, 井上 雅之, 北海道整形災害外科学会雑誌, 51, 2, 273, 273, Mar. 2010
    北海道整形災害外科学会, Japanese
  • フィールドホッケーのドリブル動作における体幹周囲筋の筋活動特性 腰痛発生との関連               
    今 小百合, 中田 周兵, 寒川 美奈, 山内 太郎, 遠山 晴一, 日本臨床スポーツ医学会誌, 17, 4, S129, S129, Oct. 2009
    (一社)日本臨床スポーツ医学会, Japanese
  • TGF-beta1の関節内投与が前十字靱帯再建術後の移植腱に与える効果 成羊モデルによる検討
    林 陸, 近藤 英司, 遠山 晴一, 齋藤 知行, 安田 和則, 臨床バイオメカニクス, 30, 121, 128, Sep. 2009
    成羊膝前十字靱帯(ACL)再建モデルを開発し、術後一年間における移植腱の力学的特性の変化を明らかにした。羊ACL再建モデルに対するTGF-β1の関節内投与は移植腱の力学的劣化を有意に抑制する、という仮説を立て、その仮説を検証した。I群では再建後の移植腱に何も投与しなかった。II群では再建後の移植腱にフィブリンのみを投与した、III群ではTGF-β1をフィブリンと混合し移植腱に投与した。手術側の膝関節は全例、腫脹が観察されたが、術後1週より腫脹は軽減した。その後、跛行は徐々に減少し、術後2週間にて正常歩行となった。関節軟骨は、軟骨変性と骨棘形成が、III群に多く認める傾向にあった。ACLの長さおよび断面積は、各群間に有意差は認めなかった。組織学的所見では、IおよびII群では移植腱中央部に無細胞領域を観察した。III群では細胞が腱深層まで浸潤し、正常に近い膠原線維の配向を示した。, (一社)日本臨床バイオメカニクス学会, Japanese
  • 解剖学的2重束ACL再建術における再建靱帯機能の術中計測 脛骨内旋時の張力変化               
    市山 廣樹, 宮武 慎, 近藤 英司, 北村 信人, 小野寺 伸, 安田 和則, 遠山 晴一, 北海道整形災害外科学会雑誌, 51, 1, 115, 115, Aug. 2009
    北海道整形災害外科学会, Japanese
  • 鏡視下解剖学的2重束前十字靱帯再建術によって作製された脛骨骨孔の関節内開口位置に関するX線学的評価
    甲斐 秀顯, 北村 信人, 近藤 英司, 河口 泰之, 遠山 晴一, 安田 和則, 水谷 一裕, 関節鏡, 34, 2, 180, 186, May 2009
    鏡視下解剖学的2重束前十字靱帯(ACL)再建術によって作製された脛骨骨孔の関節内開口位置についてX線学的評価を行った。対象は2001年7月~2006年12月までに鏡視下で解剖学的2重束ACL再建術が行われた103例103膝(男性56例、女性47例、平均年齢27.6歳)で、術後から1年経過時にX線側面像にて前内側線維束(AMB)と後外側線維束(PLB)の骨孔の位置を計測した。1)脛骨骨孔の位置では、AMB骨孔中心は脛骨前縁より平均11.4mm、27.8mm、PLB骨孔中心は同様に18.4mm、45.1mmであり、AMB前縁よりPLB後縁までの距離は平均14.1mmであった。2)術後1年時の臨床成績は、KT-2000による膝前後不安定性の平均は対健側比1.1mm、Lysholm scoreは平均97.4点であり、IKDC評価はA:72例、B:29例、C:2例であった。尚、骨高位置と膝前後不安定性、Lysholm score、IKDC評価との間に有意な相関は認められなかった。, 日本関節鏡学会, Japanese
  • 屈筋腱ハイブリッド材料を用いた前十字靱帯再再建術の臨床成績               
    宮武 慎, 近藤 英司, 北村 信人, 林 陸, 新垣 和伸, 北山 聡一郎, 横田 正司, 河口 泰之, 甲斐 秀顯, 岡本 昌市, 小野寺 伸, 遠山 晴一, 安田 和則, 北海道整形災害外科学会雑誌, 50, 2, 259, 260, Mar. 2009
    北海道整形災害外科学会, Japanese
  • 解剖学的2重束前十字靱帯再建術の臨床成績 男女間の比較               
    林 陸, 近藤 英司, 宮武 慎, 新垣 和伸, 北村 信人, 遠山 晴一, 安田 和則, 北海道整形災害外科学会雑誌, 50, 2, 261, 261, Mar. 2009
    北海道整形災害外科学会, Japanese
  • 鏡視下手術state of the art 鏡視下手術state of the art 膝十字靱帯再建術               
    遠山 晴一, 安田 和則, 近藤 英司, 北村 信人, 宮武 慎, 日本整形外科学会雑誌, 83, 3, S413, S413, Mar. 2009
    (公社)日本整形外科学会, Japanese
  • 解剖学的2重束前十字靱帯再建術後におけるX線学的骨孔径の評価
    河口 泰之, 北村 信人, 近藤 英司, 甲斐 秀顯, 井上 雅之, 遠山 晴一, 安田 和則, 膝, 33, 1, 89, 93, Mar. 2009
    膝屈筋腱ハイブリッド代用材料を用いた解剖学的2重束前十字靱帯(ACL)再建術後、骨孔拡大をX線学的に評価し得た97膝を対象とし、術後の骨孔径変化が臨床成績に与える影響を検討した。術直後と術後1年時の膝正面及び側面のレントゲンを用いて大腿骨と脛骨の骨孔を評価した結果、大腿骨側関節内開口部において大腿骨関節内前内側線維束骨孔では約18%に、後外側線維束骨孔では約10%に初期骨孔径の20%以上の拡大が認められ、脛骨関節内開口部では約8%に拡大傾向がみられたが、その頻度は1束ACL再建例に関する報告より低かった。また、骨孔拡大形状はほとんどがLinearあるいはCone typeであり、骨孔径の変化は膝前方不安定性、膝関節可動域、等速度性筋力、Lysholm Knee Scoring Scale、IKDCのいずれとも有意な相関を認めなかった。, 日本膝関節学会, Japanese
  • 変形性膝関節症の保存療法 エビデンス構築を目指して 視聴覚機器を用いた運動療法の効果               
    遠山 晴一, 安田 和則, 眞島 任史, 三浪 明男, 生駒 一憲, 日本整形外科学会雑誌, 83, 2, S28, S28, Feb. 2009
    (公社)日本整形外科学会, Japanese
  • 膝屈筋腱 ハイブリッド代用材料を用いた1束前十字靱帯再建後と解剖学的二重束前十字靱帯再建後のX線学的骨孔径変化の比較               
    河口 泰之, 北村 信人, 近藤 英司, 横田 正司, 北山 聡一郎, 甲斐 秀顯, 宮武 慎, 小野寺 伸, 井上 雅之, 遠山 晴一, 安田 和則, 日本整形外科学会雑誌, 83, 2, S120, S120, Feb. 2009
    (公社)日本整形外科学会, Japanese
  • 慢性腰痛を有するラグビーフットボール選手における腹横筋の筋活動の検討               
    浮城 健吾, 寒川 美奈, 伊藤 雄, 遠山 晴一, 山中 正紀, 日本臨床スポーツ医学会誌, 16, 4, S115, S115, Oct. 2008
    (一社)日本臨床スポーツ医学会, Japanese
  • ハムストリングス肉離れを有するラグビーフットボール選手の筋力発揮特性について               
    伊藤 雄, 寒川 美奈, 浮城 健吾, 遠山 晴一, 山中 正紀, 日本臨床スポーツ医学会誌, 16, 4, S198, S198, Oct. 2008
    (一社)日本臨床スポーツ医学会, Japanese
  • OP-1の関節内投与が家兎膝前十字靱帯実質部損傷モデルの力学的特性に与える効果               
    林 陸, 近藤 英司, 北村 信人, 宮武 慎, 岡本 昌市, 新垣 和伸, 小野寺 伸, 遠山 晴一, 安田 和則, 齋藤 知行, 北海道整形災害外科学会雑誌, 50, 1, 136, 136, Aug. 2008
    北海道整形災害外科学会, Japanese
  • Interleukin-1 receptor antagonistの投与は除負荷による膝蓋腱の力学的特性の劣化を抑制する               
    宮武 慎, 遠山 晴一, 近藤 英司, 桂 太郎, 小野寺 伸, 安田 和則, 北海道整形災害外科学会雑誌, 50, 1, 136, 137, Aug. 2008
    北海道整形災害外科学会, Japanese
  • 膝屈筋腱ハイブリッド材料を用いた解剖学的2重束前十字靱帯再建術におけるEndobutton設置に関する検討               
    宮武 慎, 近藤 英司, 北村 信人, 林 陸, 新垣 和伸, 岡本 昌市, 小野寺 伸, 遠山 晴一, 安田 和則, 北海道整形災害外科学会雑誌, 50, 1, 137, 137, Aug. 2008
    北海道整形災害外科学会, Japanese
  • 解剖学的2重束前十字靱帯再建術による再建靱帯の関節鏡学的評価とその臨床成績との関連               
    近藤 英司, 北村 信人, 小野寺 伸, 宮武 慎, 林 陸, 岡本 昌市, 小野寺 純, 新垣 和伸, 市山 廣樹, 遠山 晴一, 安田 和則, 北海道整形災害外科学会雑誌, 50, 1, 137, 138, Aug. 2008
    北海道整形災害外科学会, Japanese
  • IL-1 receptor antagonistの局所投与は除負荷膝蓋腱の力学的劣化を抑制するが、fascicleの力学特性は有意な変化を与えない               
    宮武 慎, 遠山 晴一, 近藤 英司, 桂 太郎, 小野寺 伸, 安田 和則, 日本整形外科学会雑誌, 82, 8, S937, S937, Aug. 2008
    (公社)日本整形外科学会, Japanese
  • TGF-beta 1の局所投与が前十字靱帯再建術後の移植腱に与える効果 成羊モデルによる検討               
    近藤 英司, 林 陸, 桂 太郎, 谷黒 裕子, 遠山 晴一, 安田 和則, 日本整形外科学会雑誌, 82, 8, S939, S939, Aug. 2008
    (公社)日本整形外科学会, Japanese
  • ポリオによる麻痺および頸髄症を伴う医原性動揺膝の一例               
    宮武 慎, 横田 正司, 近藤 英司, 林 陸, 新垣 和伸, 北村 信人, 小野寺 伸, 遠山 晴一, 安田 和則, 塩崎 一抄, The Japanese Journal of Rehabilitation Medicine, 45, Suppl., S163, S163, May 2008
    (公社)日本リハビリテーション医学会, Japanese
  • 前十字靱帯(ACL)・後十字靱帯(PCL)の大腿骨側付着部の研究
    寺島 尚志, 井上 雅之, 西池 修, 丹藤 世身, 近藤 英司, 遠山 晴一, 安田 和則, 関節鏡, 33, 2, 217, 222, Apr. 2008
    前十字靱帯(ACL)と後十字靱帯(PCL)における各線維束の中心を同定後、内顆・外顆を重ね回旋条件が一定となる単純X線側面像(TL-Xp)を撮影し、各線維束中心の位置を座標にて測定した。対象は切断肢7例7膝で、計測は大腿骨側面像で骨軸と平行で大腿骨後顆と接する線をX軸、それに接する点を原点としたX-Y座標で表示した。その結果、1)ACLにおける前内側線維束のX・Y座標は36.4±4.8%、38.9±2.3%で、B値(X軸から線維束中心までの距離をX軸からBlumensaat lineまでの距離で除した値)は68.7±4.2%であった。後外側線維束は同様に0.1±6.2%、27.4±2.3%で、B値42.6±2.9%であった。2)PCLの前外側線維束は-38.7±4.0%、66.9±3.4%で、B値は84.3%±3.1%であった。後内側線維束は-22.3±5.6%、48.2±8.0%で、B値は62.8±3.6%であった。以上、これらのことから、本報告は十字靱帯再建の術中ならびに術後の有用な情報になり得ると考えられた。, 日本関節鏡学会, Japanese
  • 解剖学的2重束前十字靱帯再建術の臨床成績 男女間の比較
    林 陸, 近藤 英司, 宮武 慎, 新垣 和伸, 北村 信人, 遠山 晴一, 安田 和則, 膝, 32, 2, 227, 232, Apr. 2008
    解剖学的2重束前十字靱帯(ACL)再建術における男女間の成績を比較検討した。片側ACL単独損傷に対して解剖学的2重束ACL再建術を行った174例のうち、術後1年以降に直接検診して客観的評価が可能であった126例を対象とした。術式は、Wire-navigatorを用いて脛骨および大腿骨にACLの前内側および後外側線維束の付着部中心を通る計4本の骨孔を作製し、2本の膝屈筋腱ハイブリッド材料を移植した。大腿骨側はEndo Buttonで、胚骨側はStapleで固定した。身長、体重、および移植材料の径に関しては、男性群が女性群に比べ有意に大きかった。膝前方不安定性の対健側差の平均は男性群で1.2mm、女性群で1.1mmと有意差はなかった。他の臨床評価に関しても群間に有意差はなかった。, 日本膝関節学会, Japanese
  • 北海道のスポーツ医学 現状と課題 国民体育大会と大学アメリカンフットボール
    遠山 晴一, 北海道整形災害外科学会雑誌, 49, 2, 53, 57, Mar. 2008
    北海道整形災害外科学会, Japanese
  • 変形性膝関節症のマネージメント 最新の臨床エビデンスとエキスパートオピニオン 変形性膝関節症における画像検査と生物マーカー               
    遠山 晴一, 安田 和則, 岩崎 倫政, 眞島 任史, 三浪 明男, 日本整形外科学会雑誌, 82, 2, S3, S3, Feb. 2008
    (公社)日本整形外科学会, Japanese
  • 後十字靱帯の大腿骨側付着部の研究 側面像ならびに横断像での評価               
    笠原 靖彦, 井上 雅之, 寺島 尚志, 加藤 琢磨, 大江 真人, 近藤 英司, 遠山 晴一, 安田 和則, 日本整形外科学会雑誌, 82, 2, S119, S119, Feb. 2008
    (公社)日本整形外科学会, Japanese
  • 膝屈筋腱を用いた解剖学的2重束前十字靱帯再建術におけるEndobutton設置に関する問題点の検討
    近藤 英司, 宮武 慎, 遠山 晴一, 安田 和則, 日本整形外科スポーツ医学会雑誌, 27, 2, 231, 236, Nov. 2007
    膝屈筋腱を用いて解剖学的2重束前十字靱帯再建術を行った107例を対象に、単純X線を用いて設置した計214個のEndobuttonについて検討した。その結果、Endobuttonの設置不良を11個(5%)で認められ、うち10個は後外側線維束(PLB)側に関するものであった。また、Endobuttonの明らかな軟部組織への迷入がPLB側5個、前内側線維束側1個の計6個(3%)で認められた。尚、術後、Endobuttonと大腿骨骨皮質との間に2mm以上の間隙を認めた症例はPLB側5個にみられた。, (一社)日本整形外科スポーツ医学会, Japanese
  • OP-1の関節内投与が家兎膝前十字靱帯実質部損傷モデルの力学的特性に与える効果
    林 陸, 近藤 英司, 遠山 晴一, 齋藤 知行, 安田 和則, 日本臨床バイオメカニクス学会誌, 28, 1, 7, Nov. 2007
    ウサギ前十字靱帯(ACL)損傷モデルを作製し、TGF-βスーパーファミリーの一つである骨形成蛋白質(OP)-1の関節内投与が、力学的特性に与える効果を検討した。12.5μgのrhOP-1をリン酸緩衝液にて投与したI群、リン酸緩衝液のみを投与したII群、何も投与しなかったIII群及び正常対照群に分けて比較検討した。ACL損傷モデルに対する12.5μgのOP-1の関節内投与が破断様式に関して実質部断裂例を減少させ、最大破断荷重及び線形剛性を有意に増加させた。OP-1投与により術後12週における損傷ACLの構造特性を有意に改善させたことにより、OP-1投与は損傷ACLの治癒に有効であることが示唆された。, (一社)日本臨床バイオメカニクス学会, Japanese
  • 【膝関節疾患保存療法マニュアル】膝靱帯損傷に対する保存的治療に関わるバイオメカニクス               
    遠山 晴一, 安田 和則, Orthopaedics, 20, 5, 27, 32, May 2007
    (株)全日本病院出版会, Japanese
  • 移植腱への初期張力が解剖学的2重束前十字靱帯再建術後の臨床成績に与える効果               
    北村 信人, 近藤 英司, 新垣 和伸, 小野寺 伸, 岡本 昌市, 林 陸, 宮武 慎, 遠山 晴一, 安田 和則, 日本整形外科学会雑誌, 81, 4, S535, S535, Apr. 2007
    (公社)日本整形外科学会, Japanese
  • Clinical outcome of one-stage reconstruction for chronic combined knee ligament injury
    Riku Hayashi, Eiji Kondo, Shin Miyatake, Shouichi Okamoto, Chinatsu Azuma, Jun Onodera, Shin Onodera, Harukazu Tohyama, Kazunori Yasuda, Yuko Anaguchi, Tokifumi Majima, Hokkaido Journal of Orthopaedics and Traumatology, 48, 35, 40, 01 Mar. 2007
  • ACLの修復を目指して ACL再建術に関するバイオメカニカルな問題               
    遠山 晴一, 市山 廣樹, 近藤 英司, 安田 和則, 日本整形外科学会雑誌, 81, 3, S12, S12, Mar. 2007
    (公社)日本整形外科学会, Japanese
  • 【半月板損傷の治療と実際】関節鏡視下半月板切除術の手技
    近藤 英司, 宮武 慎, 遠山 晴一, 安田 和則, 関節外科, 26, 3, 288, 292, Mar. 2007
    (株)メジカルビュー社, Japanese
  • 陳旧性膝複合靱帯損傷に対する一期的再建術の治療成績
    林 陸, 近藤 英司, 宮武 慎, 岡本 昌市, 東 千夏, 小野寺 純, 小野寺 伸, 遠山 晴一, 安田 和則, 穴口 裕子, 眞島 任史, 北海道整形災害外科学会雑誌, 48, 2, 35, 40, Mar. 2007
    北海道整形災害外科学会, Japanese
  • 外因性血管内皮細胞増殖因子が前十字靱帯再建術後の移植腱に与える効果
    吉川 寿一, 遠山 晴一, 近藤 英司, 桂 太郎, 榎本 宏之, 松本 秀男, 戸山 芳昭, 安田 和則, 膝, 31, 1, 1, 4, Mar. 2007
    血管内皮細胞増殖因子(VEGF)投与の移植腱に与える効果について成羊前十字靱帯(ACL)再建術モデルを用いて検討した。成羊18頭を投与群・非投与群の各9頭に分け、投与群では5μg/dl VEGFに15分間浸漬させた半腱様筋腱を、非投与群ではリン酸緩衝生理食塩水に浸漬させた半腱様筋腱を用いてACL再建術を施行、術後12週時に組織学的・力学的検討を行った。その結果、組織学的には投与群の移植腱表層の血管数と移植腱内の線維芽細胞数は非投与群に比べて増加していた。力学的には投与群の膝関節前後移動量は非投与群に比べた有意に高値を示し、投与群の線形剛性は非投与群に比べて有意に低値を示した。以上より外因性VEGF投与はACL再建術後の腱移植への血管新生の促進作用を有するものの、力学的には少なくとも術後12週においては移植腱剛性と関節安定性を低下させることが示唆され、臨床応用には今後より詳細な検討が必要と考えられた。, 日本膝関節学会, Japanese
  • ジクロフェナクナトリウムテープ剤(ボルタレンテープ)の経皮吸収性と組織移行性 経口剤との比較
    宮武 慎, 安田 和則, 市山 廣樹, 近藤 英司, 北村 信人, 岡本 昌市, 小野寺 伸, 林 陸, 新垣 和伸, 遠山 晴一, 医学と薬学, 57, 1, 83, 90, Jan. 2007
    ジクロフェナクナトリウム含有テープ剤を通常使用法に従って使用して一定時間経過したときの膝関節周囲軟部組織、関節液および末梢血におけるジクロフェナク濃度を、ジクロフェナクナトリウム経口剤を通常使用法に従って使用して一定時間経過したときと比較した。膝関節に明らかな疼痛・炎症・関節破壊を認め、手術(人工関節置換術)を予定した変形性膝関節症患者14名を無作為に2群に分けて対象とした。ジクロフェナク濃度は、皮下脂肪、筋肉ではテープ剤群が経口剤群より有意に高値で、滑膜、関節液ではテープ剤群が経口剤群より有意に低値であった。血漿ではテープ剤群と経口剤群に有意差はなかった。ジクロフェナクナトリウムテープ剤は消化管を介することなく、体表近くの組織に対して経口剤を上回る濃度でジクロフェナクを移行させることができる剤型であることが示唆された。, (株)自然科学社, Japanese
  • 【スポーツ損傷に対する関節鏡手術実践ガイド】スポーツ損傷の病態と治療 膝靱帯損傷
    遠山 晴一, 安田 和則, 臨床スポーツ医学, 23, 臨増, 63, 67, Nov. 2006
    (株)文光堂, Japanese
  • 【スポーツ損傷に対する関節鏡手術実践ガイド】鏡視下手術の実際 膝関節 解剖学的前十字靱帯2線維束再建術
    遠山 晴一, 安田 和則, 臨床スポーツ医学, 23, 臨増, 138, 141, Nov. 2006
    (株)文光堂, Japanese
  • NSAID搬送手段としての貼布剤の有用性の臨床研究 ジクロフェナク組織内濃度に関する貼布剤と経口剤との前向き無作為比較               
    宮武 慎, 近藤 英司, 岡本 昌市, 小野寺 純, 林 陸, 新垣 和伸, 小野寺 伸, 遠山 晴一, 安田 和則, 市山 廣樹, 日本リウマチ・関節外科学会雑誌, 25, 3, 295, 295, Oct. 2006
    (一社)日本関節病学会, Japanese
  • ENDOBUTTON-CL-BTBを組み込んだ2重束膝前十字靱帯再建用屈筋腱ハイブリッド移植材料の生体力学的評価
    宮武 慎, 近藤 英司, 小野寺 純, 林 陸, 市山 廣樹, 遠山 晴一, 安田 和則, 関節鏡, 31, 3, 129, 134, Oct. 2006
    Endo Button-CL(ECL)-BTBを組み込んだ屈筋腱hybrid材料の構造特性を明らかにし、安全性を確立しているECLを組み込んだ屈筋腱hybrid材料と比較するため新鮮凍結豚深趾屈筋腱20本を使用した。腱10本を直径6mmサイジングチューブに2重折にて通るようにトリミングし、この10本を無作為にECL群とECL-BTB群にそれぞれ分けて装着し複合体を破断させる引っ張り試験を行った。その結果、破断様式については6mm径のECL-BTBおよびECL複合体それぞれの5例すべてが腱実質部で破断した。また、7mm径のECL-BTBおよびECL複合体についてはECL-BTBの2例が腱実質部と3例がポリエステル線維部にECLの1例に腱実質部と4例にポリエステル線維部に破断を認めた。最大破断荷重については6mm径のECL-BTB複合体では両群に有意差はなく、一方7mm径のECL-BTB複合体では両群間で有意差はなかった。線形剛線性については6mm径ECL-BTB複合体では同径のECL複合体、7mm径のECL-BTB複合体、および同径のECL複合体ではいずれも両群間に有意差はなかった。すなわち、ECL-BTB複合体とECL複合体との比較では破断様式、最大破断荷重および線形剛性について有意差はなかった。以上のことから、ハイブリッド材料の作製時間を大幅に短縮できるECL-BTBは鏡視下2重束ACL再建術に有用な移植材料であると考えられた。, 日本関節鏡学会, Japanese
  • 解剖学的2重束前十字靱帯再建術において生じた術中の手技的トラブルおよび術後の合併症について
    近藤 英司, 遠山 晴一, 安田 和則, 日本整形外科スポーツ医学会雑誌, 25, 4, 393, 398, Sep. 2006
    解剖学的2重束前十字靱帯(ACL)再建術に関し、術中に生じた手技的トラブル、経過観察中に発生した合併症の実態について検討を行った。対象は205例、平均年齢26歳であった。Endobuttonの軟部組織への迷入が前内側線維束再建で2例、後外側線維束再建で6例認められた。2本にハイブリッド材料の作製不良が認められ、徒手的に張力を加えた際にテープと腱の結合部に破断を生じた。術後合併症としては、1年時における約10°の伸展制限を3例に認めた。感染、重度の関節線維症、大腿骨および骨壊死などの重篤な合併症に関しては、全く発生を認めなかった。, (一社)日本整形外科スポーツ医学会, Japanese
  • 屈筋腱を用いた膝前十字靱帯再建術における骨孔内へのTGF-βの投与が移植腱の骨孔内治癒に与える効果               
    山崎 修司, 冨田 文久, 眞島 任史, 大浦 久典, 西池 修, 三浪 明男, 安田 和則, 遠山 晴一, 北海道整形災害外科学会雑誌, 48, 1, 105, 106, Aug. 2006
    北海道整形災害外科学会, Japanese
  • 基礎と臨床の融合 腱・靱帯の再建 培養自家滑膜由来細胞投与が前十字靱帯再建術後の移植腱に与える効果 成羊モデルによる検討               
    近藤 英司, 桂 太郎, 東 千夏, 遠山 晴一, 安田 和則, 日本整形外科学会雑誌, 80, 8, S1054, S1054, Aug. 2006
    (公社)日本整形外科学会, Japanese
  • 新しい損傷モデルを用いた膝前十字靱帯損傷の治癒機序の解明とその制御に関する生体工学研究
    近藤 英司, 遠山 晴一, 安田 和則, 北海道整形災害外科学会雑誌, 48, 1, 28, 32, Aug. 2006
    北海道整形災害外科学会, Japanese
  • 陳旧性膝前十字靱帯・後十字靱帯損傷に対し解剖学的2重束同時再建を行った一症例
    林 陸, 近藤 英司, 東 千夏, 小野寺 純, 宮武 慎, 岡本 昌市, 小野寺 伸, 市山 廣樹, 遠山 晴一, 安田 和則, 石田 博英, 北海道整形災害外科学会雑誌, 48, 1, 129, 129, Aug. 2006
    北海道整形災害外科学会, Japanese
  • 【捻挫と理学療法】捻挫 受傷と回復のメカニズム               
    小林 巧, 遠山 晴一, 理学療法, 23, 7, 996, 1001, Jul. 2006
    (株)メディカルプレス, Japanese
  • 【鏡視下手術の進歩】膝関節 鏡視下前十字靱帯再建術 解剖学的2線維束再建術
    遠山 晴一, 安田 和則, 整形外科, 57, 8, 1052, 1057, Jul. 2006
    (株)南江堂, Japanese
  • 解剖学的2重束前十字靱帯再建術によって作製される骨孔角度に関するX線学的検討 Rosenberg法との比較
    近藤 英司, 市山 廣樹, 東 千夏, 遠山 晴一, 安田 和則, 日本整形外科スポーツ医学会雑誌, 25, 3, 301, 307, May 2006
    解剖学的2重束前十字靱帯(ACL)再建術によって作製される骨孔角度に関するX線学的検討を行った.対象は,解剖学的2重束ACL再建術(Y法)およびRosenberg法2重束再建術(R法)で鏡視下一皮切ACL単独再建術を受けた各群25例の計50例(男性31例,女性19例・平均年齢28歳)で,術後1年のX線正面像から大腿骨骨孔の角度(F角)及び脛骨骨孔の角度(T角)を測定し比較した.1)Y法での前内側線維束(AMB)ならびに後外側線維束(PLB)用骨孔のT角はそれぞれ平均16.5°,42.6°,R法でのT角は平均18.4°であった.2)AMB用骨孔については両群間に有意差はなかった.3)Y法でのAMBおよびPLB用骨孔のF角はそれぞれ平均17.8°,44.4°,R法でのF角はそれぞれ平均7.6°,24.1°であり,大腿骨骨孔ではAMB,PLB用骨孔とも両群間に有意差が認められた, (一社)日本整形外科スポーツ医学会, Japanese
  • 解剖学的二重束前十字靱帯再建術による再建靱帯の関節鏡学的評価とその臨床成績との関連               
    近藤 英司, 東 千夏, 市山 廣樹, 小野寺 純, 宮武 慎, 岡本 昌市, 小野寺 伸, 林 陸, 遠山 晴一, 安田 和則, 日本整形外科学会雑誌, 80, 4, S534, S534, Apr. 2006
    (公社)日本整形外科学会, Japanese
  • Posterior Stabilizer型セラミックLFA-III人工膝関節置換術の短期成績               
    奥泉 知郎, 眞島 任史, 山崎 修司, 小野寺 伸, 大浦 久典, 滝 健児, 井上 正弘, 三浪 明男, 安田 和則, 遠山 晴一, 青木 喜満, 北海道整形災害外科学会雑誌, 47, 2, 116, 116, Mar. 2006
    北海道整形災害外科学会, Japanese
  • 【関節疾患の術後の運動療法】ハムストリング腱を用いた膝十字靱帯再建術後の運動療法
    遠山 晴一, 安田 和則, 関節外科, 25, 2, 183, 188, Feb. 2006
    (株)メジカルビュー社, Japanese
  • Posterior Stabilizer型セラミックLFA-III人工膝関節の短期成績               
    奥泉 知郎, 三浪 明男, 眞島 任史, 山崎 修司, 小野寺 伸, 大浦 久典, 滝 健児, 井上 正弘, 安田 和則, 遠山 晴一, 青木 喜満, 日本人工関節学会誌, 35, 141, 142, Dec. 2005
    Posterior stabilizer(PS型)セラミックLFA-III人工膝関節置換術(TKA)を施行後1年以上経過観察が可能であった22例28膝(OA10例12膝,RA12例16膝)を対象に,短期成績について調査検討した.その結果,最終調査時のJOAスコアと全可動域はOA及びRA共に有意な改善を認めた.又,X線学的評価,Mechanical axisも良好な結果が得られたが有意差は見られず,%MAはRAの方が良好な改善が見られた.術後,早期感染例以外にコンポーネントの弛み及び沈下は見られず,インプラント周囲には1mm以上のclear zoneは認めなかった.合併症は,早期深部感染と麻酔下の関節受動術施行の各1例であった, (一社)日本人工関節学会, Japanese
  • 【靱帯再建術の最近の話題】靱帯再建術の基礎的研究の進歩
    遠山 晴一, 安田 和則, 関節外科, 24, 11, 1284, 1289, Nov. 2005
    (株)メジカルビュー社, Japanese
  • 【新世代の整形外科手術 Useful Surgical Approach 定型からオリジナルまで】大腿・膝関節 膝関節鏡におけるアプローチ               
    遠山 晴一, 安田 和則, 新OS NOW, 28, 265, 270, Nov. 2005
    (株)メジカルビュー社, Japanese
  • 自家膝屈筋腱を用いた羊膝前十字靱帯再建モデルの開発と生体力学的評価
    桂 太郎, 近藤 英司, 吉川 寿一, 東 千夏, 谷黒 裕子, 小谷 善久, 遠山 晴一, 安田 和則, 日本臨床バイオメカニクス学会誌, 26, 139, 143, Oct. 2005
    自家半腱様筋腱を用いた羊膝前十字靱帯(ACL)再建モデルの自然経過を生体力学的ならびに組織学的に評価した.右膝にACL再建を行い,術後12週で安楽死させ,9頭中7頭を力学試験へ,2頭を組織学的観察に供した.左膝から9膝を摘出し正常対照群とした.ACLの断面積および長さにおいて,群間に有意差はなかった.再建群の動揺性はACL切除後のそれと比べ有意に小さかったが,正常群のそれに比べては有意に大きかった.正常群は7例中5例に裂離骨折を認めたが,再建群は全例実質部断裂であった.最大破断荷重および線形剛性ともに再建群は正常群に比べて有意に低値であった.肉眼的所見では,再建したACLは全例において連続性があり,厚い滑膜に覆われた.組織学的所見において再建ACLは実質内に多数の細胞浸潤,規則的なコラーゲン線維の配列を認めた, (一社)日本臨床バイオメカニクス学会, Japanese
  • 血管内皮細胞増殖因子(VEGF)の局所投与が前十字靱帯再建術後の移植腱に与える効果 成羊モデルによる生体力学的検討
    吉川 寿一, 遠山 晴一, 近藤 英司, 桂 太郎, 小谷 善久, 榎本 宏之, 松本 秀男, 戸山 芳昭, 安田 和則, 日本臨床バイオメカニクス学会誌, 26, 145, 151, Oct. 2005
    成羊膝前十字靱帯(ACL)再建術モデルを用いて,外因性血管内皮細胞増殖因子(VEGF)投与がACL再建術後の移植腱の力学的特性に与える効果を検討した.VEGF投与群(I群)と非投与群(II群)の2群に分け,右膝に半腱様筋腱を用いたACL再建術を施行した.術直後は手術側の逃避性跛行を認めた.I群で特に強く手術側膝は腫脹していたが,術後4,5日より腫脹は軽減した.その後,跛行は徐々に減少し,術後2週間にて正常歩行となった.I群の移植腱周囲には著しい滑膜様組織の増生を認めた.I群ではより著しい細胞浸潤を認め,血管と思われる管状の構造もより多く認めた.II群では比較的規則的にcollagen線維が配列していた.I群の線形剛性はII群に比し有意に低値であった.最大破断荷重はI群で低い傾向があったが,両群間に有意差を認めなかった.破断形式は,全例が移植腱の実質部での断裂であった, (一社)日本臨床バイオメカニクス学会, Japanese
  • 4種類の高強度超低摩擦ダブルネットワークハイドロゲルの生体内劣化特性の生体工学的評価
    東 千夏, 田邊 芳恵, 谷黒 裕子, 遠山 晴一, 中山 温, きょう 剣萍, 長田 義仁, 安田 和則, 日本臨床バイオメカニクス学会誌, 26, 197, 204, Oct. 2005
    近年開発された最新4種類の超高強度ダブルネットワーク(DN)ハイドロゲルの材料特性およびその生体内劣化に関する特性を評価した.ゲルは,ポリ-2-アクリルアミド-2-メチルプロパンスルホン酸(PAMPS)とポリアクリルアミド(PAAm)からなるPAMPS-PAAm DNゲル,PAMPSとポリジメチルアクリルアミド(PDMAAm)から成るPAMPS-PDMAAm DNゲル,CelluloseとPDMAAmから成るCellulose-PDMAAm DNゲル,CelluloseとGelatinから成るCellulose-Gelatin DNゲルの4種類である.PAMPS-PDMAAmおよびPAMPS-PAAmゲルの表面性状は,肉眼的な観察では滑らかさが保たれており変化を認めなかった.Cellulose-PDMAAmゲルは表面の滑らかさが失われた.Cellulose-Gelatinゲルは一部の欠損や材料の変色を認めた.ダブルネットワークゲルの生体内劣化が,含まれている高分子構造によって著しく異なることが示唆された, (一社)日本臨床バイオメカニクス学会, Japanese
  • 2つの異なる初期張力を与えた解剖学的2重束前十字靱帯再建術の臨床成績の比較
    近藤 英司, 市山 廣樹, 東 千夏, 遠山 晴一, 安田 和則, 膝, 30, 1, 36, 40, Oct. 2005
    片側の単独前十字靱帯(ACL)損傷の72症例(男性41例、女性31例、13~57歳・平均28歳)に対して関節鏡下解剖学的2重束再建を施行した。初期の44例(A群)では膝屈曲30度の肢位で再建した前内側線維束(AMB)・後外側線維束(PLB)に40Nの初期張力を与え、後期の28例(B群)には同肢位で再建したAMBに50N・PLBに30Nの初期張力を与えた。移植材料には半腱様筋腱と薄筋腱を多重折りしポリエステルテープと直列結合して膝屈筋腱ハイブリッド材料を作製し用い、両群とも大腿骨側はEndobuttanで、脛骨側はStapleで固定した。術後は両群とも同一の後療法を行い、1年後に評価を行った結果、膝前方安定性の対健側側との差はA群1.1±1.7mm、B群0.9±1.5mmと両群間に有意差は認めず、A群では10度以上の伸展制限を認めた症例が2例存在したが、B群では伸展制限を認めた症例はなかった。大腿四頭筋と膝屈筋の等速度性筋力ピークトルクの対健側比及びLysholm scoreでも両群間に有意差は認めなかった。以上より両群間の臨床成績に差はないと考えられた。, 日本膝関節学会, Japanese
  • 関節鏡視下手術 押さえておくべきポイントとコツ 膝 解剖学的膝前十字靱帯再建術
    遠山 晴一, 近藤 英司, 安田 和則, 関節外科, 24, 9, 1047, 1052, Sep. 2005
    (株)メジカルビュー社, Japanese
  • 靱帯再建のためのバイオメカニクス 前十字靱帯再建術におけるバイオメカニクスの役割               
    遠山 晴一, 近藤 英司, 安田 和則, 日本整形外科学会雑誌, 79, 8, S751, S751, Aug. 2005
    (公社)日本整形外科学会, Japanese
  • Interleukin-1 Receptor Antagonistの投与は除負荷による膝蓋腱の力学的特性の劣化を抑制する               
    宮武 慎, 遠山 晴一, 近藤 英司, 桂 太郎, 小野寺 伸, 安田 和則, 日本整形外科学会雑誌, 79, 8, S840, S840, Aug. 2005
    (公社)日本整形外科学会, Japanese
  • 解剖学的前十字靱帯前内側および後外側線維束再建術によって作製される骨孔角度に関するX線学的検討 Rosenberg法との比較
    近藤 英司, 北山 聡一郎, 市山 廣樹, 東 千夏, 遠山 晴一, 安田 和則, 関節鏡, 30, 1, 39, 45, Jul. 2005
    2000年より膝屈筋腱を用いる解剖学的前十字靱帯(ACL)前内側および後外側線維束(AMB・PLB)再建術(Y法)を開発し施行している.今回,鏡視下一皮切ACL単独再建術を施行した50症例(男性31例・女性19例,年齢13~53歳・平均28歳)を従来からのRosenberg法(R法群)施行群とY法施行群の各25例を無作為抽出しX線学的に比較検討した.その結果,Y法におけるAMB用脛骨骨孔の平均T角は正面16.5度・側面40.0度,PLB用脛骨骨孔のT角は正面42.6度・側面34.4度で,いずれの標準偏差(SD)も5~6度であった.AMB用大腿骨骨孔のF角は正面17.8度・側面49.2度(R法では各々7.6度・46.6度),PLB用大腿骨骨孔のF角は正面44.5度・側面53.9度(R法では各々24.1度・38.6度)で,いずれのSDも7~8度であった.Y法群のPLB用大腿骨骨孔はR法群と有意に異なっており,以上より,Y法は特にPLB骨孔作製に関してR法とは異なる再建術式であることが示唆された, 日本関節鏡学会, Japanese
  • 【膝関節疾患外来診療マニュアル】膝関節の機能解剖とバイオメカニクス               
    遠山 晴一, 安田 和則, Orthopaedics, 18, 5, 1, 7, May 2005
    (株)全日本病院出版会, Japanese
  • 【整形外科医に必要なスポーツ医学の知識】スポーツ医学のための基礎的知識 靱帯の修復メカニズム
    遠山 晴一, 安田 和則, 整形・災害外科, 48, 5, 417, 422, Apr. 2005
    金原出版(株), Japanese
  • TGF-β1の投与が膝蓋腱中央欠損部に再生する線維性組織の力学的特性に与える効果               
    穴口 裕子, 安田 和則, 遠山 晴一, 眞島 任史, 三浪 明男, 林 紘三郎, 北海道整形災害外科学会雑誌, 46, 2, 83, 83, Mar. 2005
    北海道整形災害外科学会, Japanese
  • 【スポーツによる前十字靱帯損傷 治療の最新の進歩】解剖学的膝前十字靱帯再建術
    安田 和則, 近藤 英司, 市山 廣樹, 遠山 晴一, 臨床スポーツ医学, 22, 3, 265, 272, Mar. 2005
    (株)文光堂, Japanese
  • 解剖学的前十字靱帯前内側および後外側線維束再建術によって作製される骨孔角度に関するX線学的検討
    北山 聡一郎, 近藤 英司, 東 千夏, 市山 廣樹, 遠山 晴一, 安田 和則, 北海道整形災害外科学会雑誌, 46, 2, 6, 11, Mar. 2005
    解剖学的前十字靱帯前内側・後外側線維束(AMB・PLB)再建術(Y法)において作製した大腿骨骨孔及び脛骨骨孔の角度を明らかにするために,Y法施行の25例(Y法群)のX線正面像からAMB,PLBそれぞれの脛骨骨孔及び大腿骨骨孔と脛骨関節面のなす角(F角,T角)を測定した.また,Rosenberg法2ルート再建法(R法)施行の25例(R法群)のそれと比較検討した.Y法におけるAMB及びPLB用骨孔のT角は平均69度及び44度,F角は64度及び38度であった.R法のT角は平均67度であり,F角はAMB,PLBのF角は74度及び58度であった.F角はAMB,PLB用骨孔のいずれに関しても群間に有意差を認めた, 北海道整形災害外科学会, Japanese
  • 【鏡視下手術の実際】膝半月板損傷に対する視鏡下手術の実際               
    遠山 晴一, 安田 和則, 大越 康充, 川村 澄人, Rodeo Scott A., Orthopaedics, 17, 13, 47, 54, Dec. 2004
    (株)全日本病院出版会, Japanese
  • 中央部に1/3幅の欠損を作成した膝蓋腱に作用する張力のin vivo計測
    野口 仁志, 遠山 晴一, 安田 和則, 林 紘三郎, 日本臨床バイオメカニクス学会誌, 25, 179, 184, Nov. 2004
    Arthroscopic Force Probe(AFP)を用いて,家兎膝蓋腱から中央1/3幅の組織を切除した後に,残存腱に作用する張力を走行中にin vivo計測した.家兎膝蓋腱の中央部から1/3幅の組織を切除すると,走行中に,両側の残存膝蓋腱組織には切除前の約1.5倍(膝蓋腱全体の破断荷重の約10%)の張力が作用し,過負荷状態になることが判明した, (一社)日本臨床バイオメカニクス学会, Japanese
  • TGF-β1投与が除負荷膝蓋腱の力学的特性に与える効果
    桂 太郎, 遠山 晴一, 近藤 英司, 安田 和則, 日本臨床バイオメカニクス学会誌, 25, 191, 196, Nov. 2004
    TGF-βは線維芽細胞のコラーゲン合成促進作用を有するのみならず,組織の損傷の治癒促進作用および壊死後の靱帯組織の力学的特性の劣化の抑制作用を有することがin vivoで確認され,TGF-β1の投与が除負荷による膝蓋腱の力学特性の劣化を有意に抑止する可能性が考えられた.よって,TGF-β1投与が除負荷膝蓋腱の力学的特性に与える効果を家兎モデルで明らかにした.TGF-β投与が除負荷膝蓋腱の力学的特性に与える有意の効果を検出することはできなかった, (一社)日本臨床バイオメカニクス学会, Japanese
  • 解剖学的膝前十字靱帯前内側および後外側線維束再建術における自家屈筋腱Hybrid移植材料の作製方法と移植の実態
    東 千夏, 近藤 英司, 市山 廣樹, 吉川 寿一, 朱 寧進, 遠山 晴一, 安田 和則, 関節鏡, 29, 2, 149, 153, Oct. 2004
    2000~2002年にかけて,解剖学的AMB,PLB再建術を行った症例48人(男29人,女19人,13~57歳,平均26.4歳)を対象とした.移植された腱束の直径はAMB6mm,PLB5mmが17例,AMB7mm,PLB5mmが14例,AMB7mm,PLB6mmが16例,AMB8mm,PLB6mmが1例であった.移植された腱束の組み合わせと術後1年時の膝前方不安定性の患健側差との関係を調べたが,各組み合わせ間に有意差は認めなかった.また,半腱様筋腱のみの採取であった症例においても,術後1年時の膝前方不安定性の患健側差との関係で,各組み合わせ間に有意差は認めなかった.AMB用腱束の直径と身体データとの関係では,身長および大腿骨最大横径の双方で,直径6mm群よりも7mm群が有意に大きかった.PLB用腱束では,身長,体重,および大腿骨最大横径は直径5mm群よりも6mm群が有意に大きかった.これらの結果は,本法によって各患者の体や膝の大きさを概ね反映する太さの材料が作製されていたことを示した, 日本関節鏡学会, Japanese
  • TGF-β1およびEGFの混合投与が凍結処理家兎膝前十字靱帯の特性に与える効果               
    酒井 俊彦, 安田 和則, 遠山 晴一, 東 裕隆, 南雲 明, 眞島 任史, 北海道整形災害外科学会雑誌, 46, 1, 47, 48, Sep. 2004
    北海道整形災害外科学会, Japanese
  • 基礎の成果を臨床に バイオメカニクスからみた関節の病態-膝関節 新しい部分損傷モデルを用いた前十字靱帯損傷治癒機序の解明とその制御に関する生体医工学研究分野の創生               
    近藤 英司, 遠山 晴一, 市山 廣樹, 北村 信人, 東 千夏, 安田 和則, 日本整形外科学会雑誌, 78, 8, S819, S819, Aug. 2004
    (公社)日本整形外科学会, Japanese
  • 血管内皮細胞増殖因子の局所投与がin situ凍結処理前十字靱帯に与える効果               
    朱 寧進, 遠山 晴一, 近藤 英司, 吉川 寿一, 宗田 大, 安田 和則, 日本整形外科学会雑誌, 78, 8, S927, S927, Aug. 2004
    (公社)日本整形外科学会, Japanese
  • ACL再建 バイオメカニクスを超えて 解剖学的2ルート前十字靱帯再建術のバイオメカニクス 骨孔位置による2再建線維束の機能の違い               
    安田 和則, 市山 廣樹, 近藤 英司, 遠山 晴一, 日本整形外科学会雑誌, 78, 8, S1018, S1018, Aug. 2004
    (公社)日本整形外科学会, Japanese
  • 解剖学的2ルート前十字靱帯再建術によって再建された前内側及び後外側線維束の機能               
    市山 廣樹, 安田 和則, 遠山 晴一, 近藤 英司, 吉川 寿一, 朱 寧進, 桂 太郎, 東 千夏, 日本整形外科学会雑誌, 78, 4, S500, S500, Apr. 2004
    (公社)日本整形外科学会, Japanese
  • スポーツ外傷,障害患者に対する心理学的競技能力検査(DIPCA2)
    井上 正弘, 青木 喜満, 真島 任史, 安田 和則, 遠山 晴一, 東 裕隆, 三浪 明男, 日本臨床スポーツ医学会誌, 12, 2, 272, 277, Apr. 2004
    スポーツ外傷や障害が心理的競技能力に与える影響についての報告がこれまでなされていないため,スポーツ外来を受診したスポーツ選手,愛好家113例を対象に,心理学的競技能力検査(DIPCA2)を行った.対照は外傷・障害のない都道府県レベルの高校野球部員24名とした.その結果,患者群は,対照群よりも心理的に勝利意欲,自信,協調性の項目で低下しており,経験年数が短く,競技レベルが低くなるほど心理的能力低下がみられた.性別では,女性群でリラックス,予測力が低下していた.種目では,個人種目において団体種目よりも,勝利意欲,自己コントロール,リラックス,自信,決断力,予測力,判断力等が低下する傾向にあった.治療経過別では,障害によるスポーツ中止群で特に得点が低下していた.スポーツ外傷・障害の心理的影響がスポーツ復帰の障害となる可能性が示唆された, (一社)日本臨床スポーツ医学会, Japanese
  • 膝関節角度計測における計測値の正確性               
    笠原 靖彦, 青木 喜満, 眞島 任史, 小野寺 伸, 奥泉 知郎, 三浪 明男, 安田 和則, 遠山 晴一, 北海道整形災害外科学会雑誌, 45, 2, 50, 50, Mar. 2004
    北海道整形災害外科学会, Japanese
  • 変位制御による繰り返し負荷試験を用いた膝後十字靱帯再建4術式の生体力学的比較
    北村 信人, 安田 和則, 遠山 晴一, 近藤 英司, 池間 康成, 市山 廣樹, 北海道整形災害外科学会雑誌, 45, 2, 57, 58, Mar. 2004
    北海道整形災害外科学会, Japanese
  • 【スポーツ整形外科の手術】膝関節 後十字靱帯再建術 STG腱を用いたときの工夫               
    遠山 晴一, 安田 和則, 新OS NOW, 21, 185, 190, Feb. 2004
    (株)メジカルビュー社, Japanese
  • 冬季のスポーツ外傷の臨床 特にスノーボード及びスキーについて
    近藤 英司, 遠山 晴一, 安田 和則, 東 裕隆, 日本医事新報, 4155, 19, 24, Dec. 2003
    冬季スポーツのうちスノーボードとスキーにおけるスポーツ外傷の現状や特徴について比較した.スキー場の宿泊者にアンケート調査を行い,スノーボーダー972人,スキーヤー8213人から回答が得られた.スノーボードは外傷発生頻度が4.7外傷/1000日であり,スキー1.7外傷/1000日に対し,有意に高かった.外傷別種類はスノーボードでは骨折,捻挫,打撲が同程度に対し,スキーでは捻挫が圧倒的に多かった.部位別においてスノーボードは肩関節周囲の外傷発生頻度が高く,スキーでは膝関節周囲の外傷が多かった.スノーボードはスキーよりも重症な外傷の危険が高いことを示した, (株)日本医事新報社, Japanese
  • 除負荷がin situ凍結解凍処理膝蓋腱のサイトカイン発現に与える効果
    内田 尚哉, 遠山 晴一, 松本 秀男, 戸山 芳昭, 大場 靖子, 長嶋 和郎, 安田 和則, 膝, 28, 2, 72, 75, Dec. 2003
    日本膝関節学会, Japanese
  • Thermal Shrinkageが膝前十字靱帯の材料特性に与える急性効果
    近藤 英司, 安田 和則, 遠山 晴一, 池間 康成, 市山 廣樹, 北村 信人, 日本臨床バイオメカニクス学会誌, 24, 71, 76, Nov. 2003
    高周波エネルギーによるshrinkage処置が正常ACLの材料特性に与える効果について明らかにした.高周波エネルギーによるshrinkageは,第1にACLの長さを有意に短縮させること,第2に材料特性を劣化させること,第3に電力量がある量を越えると材料特性の劣化はさらに増加することが示された, (一社)日本臨床バイオメカニクス学会, Japanese
  • 除負荷後の再負荷が膝蓋腱の力学的特性と線維芽細胞におけるサイトカイン発現に与える効果
    内田 尚哉, 遠山 晴一, 松本 秀男, 戸山 芳昭, 大場 靖子, 長嶋 和郎, 安田 和則, 日本臨床バイオメカニクス学会誌, 24, 77, 82, Nov. 2003
    ラット50匹を用い,除負荷後の再負荷が膝蓋腱の力学的特性およびサイトカイン発現に与える効果を検討した.2週間の除負荷後に再負荷を4週間施行した群は,6週間の除負荷を施行した群に比し,IL-1βおよびTNF-α発現では有意差を認めなかった.また,TGF-β発現は有意な低下を認めたもののsham群に比し高値を維持していた.一方,力学的特性に関しては,除負荷によりもたらされた膝蓋腱の弾性率の低下を再負荷は軽度ではあるものの増加させていた, (一社)日本臨床バイオメカニクス学会, Japanese
  • 膝蓋骨脱臼に対するproximal realignmentの治療成績               
    青木 喜満, 眞島 任史, 小野寺 伸, 奥泉 知郎, 穴口 裕子, 金子 知, 笠原 靖彦, 森 律明, 三浪 明男, 安田 和則, 遠山 晴一, 原 則行, 北海道整形災害外科学会雑誌, 45, 1, 67, 67, Sep. 2003
    北海道整形災害外科学会, Japanese
  • 多重束膝屈筋腱ハイブリッド材料を用いた一皮切膝前十字靱帯再建術において脛骨及び大腿骨骨孔の傾きは術後不安定性に影響を与えるか?               
    北村 信人, 安田 和則, 遠山 晴一, 近藤 英司, 池間 康成, 市山 廣樹, 吉川 寿一, 朱 寧進, 桂 太郎, 北海道整形災害外科学会雑誌, 45, 1, 72, 72, Sep. 2003
    北海道整形災害外科学会, Japanese
  • 膝前十字靱帯に対するThermal Shrinkageの効果(第一報) 正常靱帯の力学的特性に与える急性効果               
    近藤 英司, 安田 和則, 遠山 晴一, 池間 康成, 市山 廣樹, 桂 太郎, 北村 信人, 朱 寧進, 吉川 寿一, 眞島 任史, 青木 喜満, 三浪 明男, 北海道整形災害外科学会雑誌, 45, 1, 72, 73, Sep. 2003
    北海道整形災害外科学会, Japanese
  • 解剖学的前十字靱帯再建術によって再建される前内側・後外側線維束のlength patternに関するin vivo計測
    市山 廣樹, 安田 和則, 遠山 晴一, 近藤 英司, 北村 信人, 池間 康成, 吉川 寿一, 朱 寧進, 眞島 任史, 膝, 28, 1, 108, 112, Sep. 2003
    日本膝関節学会, Japanese
  • 関節炎発症におけるマクロファージ遊走阻止因子(MIF)の意義 マウスカクテル誘発関節炎モデルによるin vivoでの検討               
    市山 廣樹, 遠山 晴一, 安田 和則, 近藤 英司, 北村 信人, 吉川 寿一, 朱 寧心, 小野寺 伸, 日本整形外科学会雑誌, 77, 8, S997, S997, Aug. 2003
    (公社)日本整形外科学会, Japanese
  • 足関節靱帯損傷のバイオメカニクス               
    遠山 晴一, 安田 和則, リウマチ科, 30, 2, 187, 192, Aug. 2003
    (有)科学評論社, Japanese
  • 脛骨側に高度骨欠損を有する膝に骨移植を併用した人工膝関節置換術の成績               
    奥泉 知郎, 青木 喜満, 眞島 任史, 宮城 登, 小野寺 伸, 笠原 靖彦, 穴口 裕子, 三浪 明男, 遠山 晴一, 安田 和則, 日本整形外科学会雑誌, 77, 4, S588, S588, Apr. 2003
    (公社)日本整形外科学会, Japanese
  • 脛骨に対する骨移植を併用した人工膝関節置換術の成績               
    奥泉 知郎, 青木 喜満, 眞島 任史, 宮城 登, 伊藤 浩, 小野寺 伸, 穴口 裕子, 金子 知, 三浪 明男, 安田 和則, 遠山 晴一, 北海道整形災害外科学会雑誌, 44, 2, 72, 72, Mar. 2003
    北海道整形災害外科学会, Japanese
  • 後十字靱帯温存型セラミックLFA人工膝関節の臨床的評価 専用手術器具の正確性及び再現性の評価               
    内田 淳, 眞島 任史, 青木 喜満, 宮城 登, 伊藤 浩, 穴口 裕子, 奥泉 知郎, 金子 知, 三浪 明男, 遠山 晴一, 安田 和則, 北海道整形災害外科学会雑誌, 44, 2, 74, 75, Mar. 2003
    北海道整形災害外科学会, Japanese
  • スポーツ外来における心理的競技能力診断検査(DIPCA2)について               
    井上 正弘, 青木 喜満, 眞島 任史, 安田 和則, 遠山 晴一, 東 裕隆, 北海道整形災害外科学会雑誌, 44, 2, 126, 126, Mar. 2003
    北海道整形災害外科学会, Japanese
  • 膝関節角度計測における計測値の正確性 preliminary study               
    青木 喜満, 宮城 登, 眞島 任史, 伊藤 浩, 小野寺 伸, 穴口 裕子, 奥泉 知郎, 金子 知, 三浪 明男, 安田 和則, 遠山 晴一, 近藤 英司, 北村 信人, 酒井 俊彦, 北海道整形災害外科学会雑誌, 44, 2, 77, 78, Mar. 2003
    北海道整形災害外科学会, Japanese
  • 自家屈筋腱を用いた解剖学的前十字靱帯前内側及び後外側線維束再建術の臨床成績 従来の1及び2ルート再建法との比較               
    近藤 英司, 安田 和則, 田邊 芳恵, 遠山 晴一, 池間 康成, 市山 廣樹, 北村 信人, 眞島 任史, 青木 喜満, 三浪 明男, 日本整形外科学会雑誌, 77, 3, S91, S91, Mar. 2003
    (公社)日本整形外科学会, Japanese
  • 【わが国で開発された人工膝関節】セラミックLFA人工膝関節システム               
    安田 和則, 井上 雅之, 遠山 晴一, 青木 喜満, 真島 任史, 三浪 明男, 関節外科, 22, 3, 347, 355, Mar. 2003
    (株)メジカルビュー社, Japanese
  • 膝蓋腱由来の線維芽細胞の対基質浸潤能及び浸潤が及ぼす力学的効果 外来性及び正常線維芽細胞間の比較
    池間 康成, 遠山 晴一, 中村 秀樹, 金谷 文則, 安田 和則, 北海道整形災害外科学会雑誌, 44, 2, 5, 9, Mar. 2003
    膝蓋腱由来の外来性線維芽細胞と正常線維芽細胞を単離し,無細胞の腱マトリクスへin vivoで浸潤させ得る実験系を確立し,両線維芽細胞が有する浸潤能を比較し,浸潤が腱マトリクスの力学的特性に与える効果を比較検討した.外来性線維芽細胞の浸潤能は正常線維芽細胞に比べ,有意に低値であった.腱マトリクスのタンジェント・モジュラスは,いずれの細胞浸潤後にも経時的に有意に減少しており,外来性線維芽細胞を含んでいる試料,正常線維芽細胞を含んでいる試料と細胞を含まない試料の間で有意差を認めなかった, 北海道整形災害外科学会, Japanese
  • RA膝に対する脛骨側に骨移植を併用した人工膝関節置換術の成績               
    奥泉 知郎, 青木 喜満, 真島 任史, 宮城 登, 伊藤 浩, 小野寺 伸, 穴口 裕子, 金子 知, 三浪 明男, 安田 和則, 遠山 晴一, 北海道医学雑誌, 78, 1, 87, 88, Jan. 2003
    北海道医学会, Japanese
  • PDGF-BBの投与が損傷を受けた膝前十字靱帯の力学的特性に与える影響
    近藤 英司, 安田 和則, 遠山 晴一, 池間 康成, 市山 廣樹, 北村 信人, 山中 正紀, 日本臨床バイオメカニクス学会誌, 23, 19, 23, Nov. 2002
    家兎を用いて膝前十字靱帯(ACL)損傷モデルを作製し,無処置(A群),フィブリン糊関節内投与(B群),PDGF-BB投与(C群)に分けて12週後に膝屈曲30°,60°,90°で15Nの前後方向荷重を加え,大腿骨に対する脛骨の移動距離を測定した.その結果,30°ではA群3.2mm,B群3.3mm,C群3.1mmで3群間に有意差はなく,60°,90°でも同様であった.次にACL以外の軟部組織を除去して大腿骨-ACL-脛骨複合体とし,引張試験を行った.ACL長,平均断面積に有意差はなかった.破断様式はA群で7膝中6膝,B群5膝,C群6膝が実質部で断裂した.線形剛性はA群73.9N/mm,B群76.6N/mm,C群78.0N/mm,最大破断荷重は各々174.9N,176.7N,166.9Nで,有意差はなかった.PDGF-BBの関節内投与は損傷ACLの力学的特性に効果を与えないことが示された, (一社)日本臨床バイオメカニクス学会, Japanese
  • 前十字靱帯再建術における屈筋腱を用いたBone MulchTM ScrewとWasherLocTM固定法の繰り返し負荷試験による生体力学的評価
    工藤 敏治, 青木 喜満, 遠山 晴一, 北村 信人, 安田 和則, 沼崎 広法, 日本臨床バイオメカニクス学会誌, 23, 209, 213, Nov. 2002
    ブタ新鮮凍結膝関節の屈筋腱をBone Mulch-Screw/WasherLocで固定した再建術(A群)とEndobuttonを用いた再建術(B群)において,5000回の繰り返し伸びを与えた際の大腿骨-移植腱-脛骨(FGT)複合体の力学的挙動を比較した.ピーク張力は両群とも初回より100回以内に急速に低下し,A群は1回目180N,5000回目55N,B群は各々83N,17Nと有意差を認めた.初期剛性に関しては,繰り返し負荷を行わない場合でA群86N/mm,B群37N/mmで,繰り返し負荷を加えた場合は各々29N/mm,9N/mmと有意差を認めた.線形剛性は,負荷なしでA群91N/mm,B群25N/mm,負荷後は各々98N/mm,26N/mmと有意差を認めた.平均最大破断荷重は両群間に有意差はなく,負荷の有無でも差はなかった.破断様式は負荷の有無に関わらずA群は全例脛骨側の移植腱とWasherLocの移行部において破断し,B群ではtapeの破断を負荷なし1複合体,負荷後2複合体に認めた以外は,全て糸の破断であった, (一社)日本臨床バイオメカニクス学会, Japanese
  • 【整形外科医に必要なバイオメカニクス基礎知識と最近の話題】最近の話題 膝靱帯再建術のバイオメカニクス 移植腱に加える張力の重要性               
    遠山 晴一, 安田 和則, 関節外科, 21, 10月増刊, 155, 160, Oct. 2002
    (株)メジカルビュー社, Japanese
  • 【ヒアルロン酸製剤(関節機能改善剤)をどう用いるか】各病態と関節機能改善剤の臨床使用 スポーツ外傷への応用               
    遠山 晴一, 医薬ジャーナル, 38, 10, 2806, 2810, Oct. 2002
    スポーツ外傷の中で,長い治療期間を要するとされてきた半月板損傷や,靱帯損傷後の軟骨損傷に対するヒアルロン酸製剤の効果に関し,種々の動物実験がなされてきた.その結果,ヒアルロン酸製剤投与は,半月板損傷治癒の促進及び半月板切除後の残存半月板変性の抑止効果,更には前十字靱帯不全による関節軟骨変性の防止効果を有することが示唆されている.又,スポーツ外傷による軟骨欠損例に対してもヒアルロン酸ナトリウムは種々の手術療法の併用療法として効果的なものと考えられた.したがって,今後,スポーツ外傷に対するヒアルロン酸療法に関する臨床成績を集積し,本療法をスポーツ外傷に対する治療として確立することが期待される, (株)医薬ジャーナル社, Japanese
  • 脛骨側に高度骨欠損を有するRA膝に対して骨移植を併用した人工膝関節置換術の治療成績               
    奥泉 知郎, 青木 喜満, 眞島 任史, 宮城 登, 小野寺 伸, 笠原 靖彦, 三浪 明男, 安田 和則, 遠山 晴一, 日本リウマチ・関節外科学会雑誌, 21, Suppl., 77, 77, Sep. 2002
    (一社)日本関節病学会, Japanese
  • スポーツ外来における心理的競技能力検査 心理的能力低下例の検討               
    井上 正弘, 青木 喜満, 真島 任史, 安田 和則, 遠山 晴一, 東 裕隆, 三浪 明男, 日本臨床スポーツ医学会誌, 10, 4, S107, S107, Sep. 2002
    (一社)日本臨床スポーツ医学会, Japanese
  • TGF-β1の投与が膝蓋腱中央欠損部に再生する線維性結合組織の生体力学的特性に与える効果               
    穴口 裕子, 安田 和則, 眞島 任史, 遠山 晴一, 青木 喜満, 奥泉 知郎, 金子 知, 三浪 明男, 林 鉱三郎, 日本整形外科学会雑誌, 76, 8, S1125, S1125, Aug. 2002
    (公社)日本整形外科学会, Japanese
  • 変位制御による繰り返し負荷試験を用いた膝後十字靱帯再建4術式の生体力学的比較               
    北村 信人, 安田 和則, 遠山 晴一, 近藤 英司, 池間 康成, 市山 廣樹, 吉川 寿一, 山中 雅智, 日本整形外科学会雑誌, 76, 8, S921, S921, Aug. 2002
    (公社)日本整形外科学会, Japanese
  • 後十字靱帯温存型セラミックス製LFA人工膝関節の開発コンセプトとその2~8年成績
    安田 和則, 井上 雅之, 東 裕隆, 谷岡 寛子, 遠山 晴一, 真島 任史, 青木 喜満, 三浪 明男, 臨床整形外科, 37, 8, 961, 969, Aug. 2002
    セラミックス製LFA-I人工膝関節による人工膝関節置換術(TKA)症例81人105膝(手術時年齢42~83歳)の2~8年の成績について検討した.破損例1膝,遅発性感染例1膝の成績不良例を除くと,JOA評価点はいずれの疾患でも著明に改善した.特に,疼痛の改善は顕著であった.X線学的評価では弛みや骨融解は認めず,幅が1mm以下の限局した骨透亮線は,大腿骨側で前方骨切り面近位部に2%,脛骨側で脛骨トレイ直下の一部に4%の頻度でみられたが,1mm以上の骨透亮線はどこにも認めなかった, (株)医学書院, Japanese
  • 高位脛骨骨切り術後の人工膝関節置換術の問題点               
    青木 喜満, 宮城 登, 真島 任史, 伊藤 浩, 山崎 修司, 穴口 裕子, 三浪 明男, 安田 和則, 遠山 晴一, 沼崎 広法, 北海道整形災害外科学会雑誌, 44, 1, 86, 87, Jul. 2002
    北海道整形災害外科学会, Japanese
  • 【整形外科術前・術後の理学療法】膝靱帯再建術と理学療法
    山中 正紀, 遠山 晴一, 理学療法, 19, 6, 723, 728, Jun. 2002
    (株)メディカルプレス, Japanese
  • 運動器の細胞 知っておきたい 靱帯の細胞 線維芽細胞(Fibroblast)
    遠山 晴一, 安田 和則, 臨床整形外科, 37, 5, 624, 627, May 2002
    (株)医学書院, Japanese
  • 【膝靱帯損傷の診断治療マニュアル】前十字靱帯損傷の治療に対する生体力学的アプローチ               
    遠山 晴一, 安田 和則, Orthopaedics, 15, 4, 20, 27, Apr. 2002
    選択的に内在性線維芽細胞壊死を生じさせるin situ凍結解凍処理モデルを用いた生体力学的研究を行ってきた.その結果,自家腱移植においては,線維芽細胞壊死自体は移植腱に殆ど影響を与えず,その後に浸潤する外来性細胞の生物学的反応が移植腱の力学強度を低下させること,細胞壊死後の浸潤細胞による小径フィブリル径を有するIII型コラーゲンの産生が自家移植腱の力学的劣化の一因である可能性,弛緩させた凍結解凍処理前十字靱帯の力学特性は術後早期に低下するのに対し,過度の張力は緩徐にその力学的特性を減少させること,TGF-βをはじめとする成長因子の応用により再建前十字靱帯の再構築過程を促進させる可能性等の知見を得た, (株)全日本病院出版会, Japanese
  • 後十字靱帯温存型セラミックLFA人工膝関節の臨床的評価(第二報) 専用手術器具の正確性及び再現性の評価               
    眞島 任史, 青木 喜満, 宮城 登, 穴口 裕子, 奥泉 知郎, 金子 知, 内田 淳, 三浪 明男, 遠山 晴一, 安田 和則, 日本整形外科学会雑誌, 76, 3, S176, S176, Mar. 2002
    (公社)日本整形外科学会, Japanese
  • 多重束屈筋腱ハイブリッド材料を用いた一皮切膝前十字靱帯再建術において脛骨骨孔の方向は術後不安定性に影響を与えるか?               
    北村 信人, 安田 和則, 遠山 晴一, 近藤 英司, 池間 康成, 市山 廣樹, 日本整形外科学会雑誌, 76, 3, S29, S29, Mar. 2002
    (公社)日本整形外科学会, Japanese
  • 多重束膝屈筋腱ハイブリッド材料を用いた膝前十字靱帯再建術の臨床成績における大腿骨側1骨孔法と2骨孔法の比較               
    近藤 英司, 安田 和則, 遠山 晴一, 池間 康成, 市山 廣樹, 北村 信人, 眞島 任史, 青木 喜満, 三浪 明男, 日本整形外科学会雑誌, 76, 3, S162, S162, Mar. 2002
    (公社)日本整形外科学会, Japanese
  • 高位脛骨骨切術術後における人工膝関節置換術の問題点
    沼崎 広法, 安田 和則, 遠山 晴一, 青木 喜満, 三浪 明男, 菊地 臣一, 東日本整形災害外科学会雑誌, 14, 1, 117, 120, Mar. 2002
    高位脛骨骨切術(HTO)術後に人工膝関節置換術(TKA)を施行した9例10膝を対象に,臨床的問題について検討した.膝蓋骨反転が困難で,大腿四頭筋のV-Y形成術を1膝,脛骨粗面骨切術を1膝に要した.6膝で膝窩筋腱と外側側副靱帯の剥離を要し,2膝では腸脛靱帯延長術の追加を要した.1膝で内側側副靱帯の再建術を要した.HTO後のTKAでは,膝蓋骨の反転の困難性,脛近位部の脛骨骨軸に対する外側偏位,および内外側靱帯バランスに留意すべきである, 東日本整形災害外科学会, Japanese
  • 当科における陳旧性膝重度複合靱帯損傷の最近の10例の治療成績の検討               
    穴口 裕子, 青木 喜満, 宮城 登, 山崎 修司, 大本 浩史, 安田 和則, 真島 任史, 遠山 晴一, 北海道整形災害外科学会雑誌, 43, 2, 127, 128, Dec. 2001
    北海道整形災害外科学会, Japanese
  • TGF-β及びEGFの混合投与が凍結処理家兎膝前十字靱帯(再建モデル)の力学的特性に与える効果 投与時期の影響
    東 裕隆, 安田 和則, 酒井 俊彦, 遠山 晴一, 眞島 任史, 青木 喜満, 三浪 明男, 北海道整形災害外科学会雑誌, 43, 2, 1, 4, Dec. 2001
    右の膝前十字靱帯(ACL)の線維芽細胞を凍結処理により死滅させた日本白色家兎24羽を4群に分け,トランスフォーミング増殖因子ベータ(TGF-β)および表皮増殖因子(EGF)を少量投与した.引っ張り強度および剛性率は,3週目にTGF-βおよびEGF,フィブリン糊を投与したG/F3群6羽が他群より有意に高かった.断面積に関しては,G/F3群は他群より有意に小さかった.投与時期により,これらの成長因子が凍結処理前のACLの力学的特性に影響を及ぼしていることが示された, 北海道整形災害外科学会, Japanese
  • ニセコスキー場におけるスノーボード外傷 9年間の調査によるスキー外傷との比較
    東 裕隆, 安田 和則, 遠山 晴一, 眞島 任史, 青木 喜満, 三浪 明男, 九津見 圭司, 杉原 進, 北海道整形災害外科学会雑誌, 43, 2, 5, 8, Dec. 2001
    1988年からの9シーズンにわたり,スノーボード(ボード)による外傷626例とスキー外傷2769例について比較検討した.ボードおよびスキー外傷における平均年齢は22.8対31.4歳,男性の占める割合は78.5対58.0%であった.また,ボードの経験年数は,1年以内のビギナーと3年目に多い二峰性を示した.傷害は,前者は後者に比べ,骨折などより重篤なものが多かった.受傷転機はジャンプの着地失敗によるものが多く,損害部位については,前者は体幹や上肢,後者は下肢に多く認めた.ボードによる外傷患者数は経年的に増加しており,義務教育レベルからの安全教育と指導員の養成が急務と考えられた, 北海道整形災害外科学会, Japanese
  • 除負荷がラット膝蓋腱の力学的特性とTransforming Growth Factor-βの発現に与える効果に関する解析
    内田 尚哉, 遠山 晴一, 安田 和則, 松本 秀男, 戸山 芳昭, 大場 靖子, 長嶋 和郎, 膝, 26, 184, 188, Dec. 2001
    日本膝関節学会, Japanese
  • 【スポーツ外傷・障害の理学診断・理学療法ガイド】事例解説 前十字靱帯損傷(再建例)
    遠山 晴一, 安田 和則, 臨床スポーツ医学, 18, 臨増, 249, 253, Nov. 2001
    (株)文光堂, Japanese
  • 【スノーボード外傷の最近の傾向】スノーボード外傷の疫学的特徴(スキー外傷との比較)
    遠山 晴一, 九津見 圭司, 安田 和則, 臨床スポーツ医学, 18, 11, 1209, 1213, Nov. 2001
    (株)文光堂, Japanese
  • 【整形外科鏡視下手術の進歩と実際】多重束膝屈筋腱を用いた鏡視下後十字靱帯再建術               
    遠山 晴一, 安田 和則, 酒井 俊彦, 関節外科, 20, 10, 1303, 1310, Oct. 2001
    多重束膝屈筋腱-ハイブリッド代用材料を用いた鏡視下膝後十字靱帯(PCL)再建術について,術式を中心に論述した.この方法の安定した術後成績は正しい術式に加え,多重束膝屈筋腱-ハイブリッド代用材料の十分な太さ,強度,初期錨着力及び多重束膝屈筋腱が有する広い許容度に起因するものである, (株)メジカルビュー社, Japanese
  • 生体吸収性Polydioxanoneテープを組み込んだhybrid型人工靱帯の骨孔内治癒に関する多角的評価
    冨田 文久, 青木 喜満, 宮城 登, 安田 和則, 遠山 晴一, 日本臨床バイオメカニクス学会誌, 22, 89, 94, Oct. 2001
    標記人工靱帯について,糸の太さ・量の差が骨孔内治癒に及ぼす影響を実験動物で検討した.その結果,前十字靱帯再建において直径約0.01mmのPolydioxanone(PD)糸からなるhybrid型靱帯を用いた場合,同等の初期強度をもつ直径0.6mmのPD糸からなるhybrid型靱帯を用いた場合よりも異物反応が強く,骨孔が拡大する傾向にあった.この結果より,吸収性PD繊維からなるhybrid型靱帯の骨孔内治癒には糸の直径と量が大きな影響を与えることが示唆された, (一社)日本臨床バイオメカニクス学会, Japanese
  • 頸椎後縦靱帯の生体力学的特性 中央線維束と外側線維束との比較
    南雲 明, 原田 征行, 安田 和則, 遠山 晴一, 日本臨床バイオメカニクス学会誌, 22, 221, 225, Oct. 2001
    豚を用い,頸椎後縦靱帯における中央線維束と外側線維束の力学的特性及び微細構造を比較検討した.中央線維束の弾性係数と引張強度は外側線維束に比べて有意に高かった.微細構造に関しては,中央線維束のcrimp patternは外側線維束に比べてより頸椎長軸方向へ均一に配行し,力学的特性の結果を裏付けた, (一社)日本臨床バイオメカニクス学会, Japanese
  • In situ凍結解凍処理後前十字靱帯に対する外因性成長因子の効果
    沼崎 広法, 菊地 臣一, 遠山 晴一, 酒井 俊彦, 安田 和則, 日本臨床バイオメカニクス学会誌, 22, 99, 103, Oct. 2001
    標記靱帯においてPDGF-BB単独投与及びTGF-βとEGFの混合投与が内在性線維芽細胞壊死後の前十字靱帯の力学特性に与える影響を家兎で検討した.その結果,PDGF-BBの投与は有意な影響を与えず,TGF-β+EGFの投与は力学特性を有意に改善させることが明らかになった, (一社)日本臨床バイオメカニクス学会, Japanese
  • 家兎における新しい膝前十字靱帯実質部損傷モデルの生体力学的評価
    近藤 英司, 安田 和則, 遠山 晴一, 内田 尚哉, 北村 信人, 池間 康成, 山中 正紀, 日本臨床バイオメカニクス学会誌, 22, 325, 331, Oct. 2001
    靱帯実質内にコラーゲン線維束の損傷が広範囲に存在し弛緩しているが,みかけ上の連続性は保たれているような新しいタイプの家兎膝前十字靱帯損傷モデルを開発した.その自然経過を観察した結果,いずれの時期においても連続性が保たれていることが確認され,自然治癒過程に関しても再現性の高いことが示された, (一社)日本臨床バイオメカニクス学会, Japanese
  • 除負荷が膝蓋腱の力学的特性とサイトカイン発現に与える効果               
    内田 尚哉, 遠山 晴一, 安田 和則, 大場 靖子, 長嶋 和郎, 松本 秀男, 戸山 芳昭, 日本整形外科学会雑誌, 75, 8, S1111, S1111, Aug. 2001
    (公社)日本整形外科学会, Japanese
  • 陳旧性膝重度複合靱帯損傷に対する同時再建術 当科における最近の成績               
    穴口 裕子, 安田 和則, 遠山 晴一, 青木 喜満, 真島 任史, 三浪 明男, 日本整形外科スポーツ医学会雑誌, 21, 3, 214, 214, Aug. 2001
    (一社)日本整形外科スポーツ医学会, Japanese
  • TGF-β及びEGFの少量関節内投与が凍結処理前十字靱帯の力学的特性に与える効果は担体によって異なるか?               
    東 裕隆, 安田 和則, 遠山 晴一, 真島 任史, 青木 喜満, 三浪 明男, 日本整形外科学会雑誌, 75, 8, S922, S922, Aug. 2001
    (公社)日本整形外科学会, Japanese
  • 損傷を受けた膝前十字靱帯の治癒にTGF-βの関節内投与が与える効果               
    近藤 英司, 安田 和則, 遠山 晴一, 眞島 任史, 山中 正紀, 日本整形外科学会雑誌, 75, 8, S1112, S1112, Aug. 2001
    (公社)日本整形外科学会, Japanese
  • 半腱様筋腱及び薄筋腱から作成できる移植用自家腱束の直径が分布する範囲
    近藤 英司, 安田 和則, 田邊 芳恵, 遠山 晴一, 眞島 任史, 内田 尚哉, 北村 信人, 池間 康成, 関節鏡, 26, 1, 89, 92, Jul. 2001
    2重または3重折りした半腱様筋腱および薄筋腱を用いてACL再建術を行った症例の,移植用自家腱束の直径計測を行った.2重折りした67例の直径は,男性では7mmが26%,8mmが37%,9mmが18%,10mmが18%,女性では6mmが14%,7mmが41%,8mmが28%,9mmが14%,10mmが3%であった.平均は7.5mm,標準偏差は±1.0mmであった.3重折りした230例の直径は,男性では7mmが4%,8mmが11%,9mmが43%,10mmが39%,11mmは4%で,平均は93mm,標準偏差は±0.8mmであった.女性では7mmが12%,8mmが33%,9mmが43%,10mmは13%であった.平均は8.6mm,標準偏差は±0.9mmでった.2重折り3重折り共に,男女間に有意差を認めた, 日本関節鏡学会, Japanese
  • 生体吸収性人工靱帯部を有する膝屈筋腱hybrid代用材料の開発に関する基礎的検討
    冨田 文久, 安田 和則, 遠山 晴一, 青木 喜満, 宮城 登, 筏 義人, 膝, 25, 174, 178, Feb. 2001
    日本膝関節学会, Japanese
  • 膝後十字靱帯単独損傷に対する多重束膝屈筋腱-hybrid代用材料を用いた鏡視下後十字靱帯再建術の術後成績
    酒井 俊彦, 安田 和則, 遠山 晴一, 青木 喜満, 宮城 登, 関節鏡, 25, 2, 233, 237, Dec. 2000
    多重束膝屈筋腱ハイブリッド代用材料を用いて,後十字靱帯(PCL)を再建した22人22膝を対象として治療成績を検討した.関節可動域は屈曲は平均145度と良好であった,術前よりも屈曲制限が増大した症例は1膝のみであった.sagging徴候は全例で術前陽性であったが,術後11膝で消失していた.ストレスX線写真計測,対健側差,膝前後総合動揺性,大腿四頭筋の等速度性収縮筋力は術後に改善を認めた.一方,膝屈筋の筋力は術前後に大きな変化を認めなかった.Lysholmスコアは,95点以上が18膝,90~94点が3膝,89点以下が1膝であった.IKDC評価では,正常が6膝,ほぼ正常が12膝,異常が4膝,著明な異常が0膝であった, 日本関節鏡学会, Japanese
  • 肩腱板断裂の治療成績 術後ヒアルロン酸ナトリウム投与の影響
    福田 公孝, 景浦 暁, 遠山 晴一, 伊東 学, 伊嶋 健一, 薬理と治療, 28, 9, 819, 823, Sep. 2000
    腱板手術後のヒアルロン酸ナトリウムの肩峰下滑液包への投与は,後療法時の疼痛を防止する効果があり,有用であった.術後ROMの改善に対する効果,即ち,肩峰下滑液包での癒着防止の効果は不明であった, ライフサイエンス出版(株), Japanese
  • 【足関節外側靱帯損傷の診断と治療】足関節外側靱帯損傷とバイオメカニクス               
    遠山 晴一, 安田 和則, 大関 覚, Beynnon B.D., Renstrom P.A., Orthopaedics, 13, 10, 1, 8, Sep. 2000
    足関節外側靱帯損傷に関するバイオメカニクス的研究の概要とその臨床的意義を紹介した.これら研究により,1)前距腓靱帯損傷診断のための前方引き出し試験の至適位置及び荷重量,2)Chrisman-Snook法による靱帯再建術後足関節の力学的挙動,3)解剖学的靱帯再建術におけるisometric pointの解明,4)足関節外側靱帯損傷後の早期荷重訓練の安全性などが明らかとなった.足関節外側靱帯損傷に対する診断及び治療において,バイオメカニクス的手法による研究は有用な情報をもたらすものと考えられた, (株)全日本病院出版会, Japanese
  • 【膝関節overuse syndrome】その基礎と臨床 Over loadによる腱の変化
    遠山 晴一, 安田 和則, 臨床スポーツ医学, 17, 4, 393, 398, Apr. 2000
    (株)文光堂, Japanese
  • スノーボードによる脊椎・脊髄損傷 スキー外傷との比較
    東 裕隆, 安田 和則, 遠山 晴一, 白土 修, 青木 喜満, 日本臨床スポーツ医学会誌, 8, 2, 185, 193, Apr. 2000
    (一社)日本臨床スポーツ医学会, Japanese
  • 骨成長終了前に脛骨近位内側の骨端線が閉鎖したBlount病の治療経験               
    宮城 登, 青木 喜満, 山崎 修司, 冨田 文久, 金田 清志, 安田 和則, 遠山 晴一, 膝, 24, 114, 117, Dec. 1999
    日本膝関節学会, Japanese
  • 非生理的な負荷が移植膝蓋腱に与える影響 in situ凍結解凍処理膝蓋腱を用いた力学的検討               
    遠山 晴一, 安田 和則, 東 裕隆, 大野 和則, 真島 任史, 膝, 24, 13, 16, Dec. 1999
    1)ウサギ凍結解凍処理膝蓋腱を用いて非生理的な負荷が膝蓋腱の力学的特性に与える影響を検討した. 2)その結果,非生理的な負荷軽減は線維芽細胞壊死後の膝蓋腱の力学的特性を鋭敏に低下させた. 3)ある閾値をこえた負荷増大は比較的緩徐に線維芽細胞壊死後の膝蓋腱の力学的特性を低下させる, 日本膝関節学会, Japanese
  • 【膝の外科】膝の機能解剖と生体力学 膝の機能解剖と生体力学               
    遠山 晴一, 安田 和則, NEW MOOK 整形外科, 7, 1, 13, Oct. 1999
    膝関節の機能解剖,膝関節構成体の生体力学(靱帯,関節軟骨,半月板,膝周囲筋)について解説した.膝関節は,骨の形態,動的支持組織及び静的支持組織により制御され,関節の運動が誘導されている.膝関節には屈曲・伸展,内外旋,内外反方向の三つの回旋運動と内外側,近遠位,前後方向の三つの並行運動の6種類の運動が生じる.これらの運動が生理的範囲を逸脱し増加した状態を不安定と呼び,膝関節構成体の破綻を意味する, 金原出版(株), Japanese
  • 【膝の外科】移植膝蓋腱のリモデリング機序               
    安田 和則, 遠山 晴一, NEW MOOK 整形外科, 7, 185, 192, Oct. 1999
    in situで凍結解凍処理した家兎膝蓋腱を用いて,遊離自家組織移植の本質である線維芽細胞壊死が膝蓋腱のリモデリングに与える効果を調べた.線維芽細胞壊死それ自体は,腱の力学的特性の低下をもたらさず,その後に腱内へ侵入する外因性細胞が腱の力学的特性を低下させていた.一方,新しい細胞が侵入する3週以後,膝蓋腱の断面積が増加し,引張強度の低下を補って膝蓋腱全体の最大破断荷重の低下を可及的に少ないものにしていた.超微細構造学的観察によれば,線維芽細胞壊死後に侵入する外因性細胞は90nm以下の直径を有する細いコラーゲンフィブリルを産生し,その結果コラーゲン線維が腱断面積に占める割合を減少させ,これが力学的強度の低下を生じさせることが示唆された, 金原出版(株), Japanese
  • 【スノーボード外傷】スノーボード及びスキー外傷の疫学的特徴 前向き調査による検討
    遠山 晴一, 安田 和則, 青木 喜満, 骨・関節・靱帯, 12, 9, 1087, 1090, Sep. 1999
    1995年12月から1996年3月迄にニセコ国際ひらふスキー場隣接施設に宿泊した18570人を対象に調査し,10009人の回答を得た.スノーボーダーは男508人,女464人,スキーヤーは男4293人,女3920人,両方は男423人,女401人であった.外傷発生頻度はスノーボーダーが有意に高かった.部位ではスノーボーダーは頭頸部,顔面,肩関節,上肢,膝に多く,スキーでは膝周辺が多かった.骨折はボーダーでは257例,スキーは72,捻挫は各々151例,222例,打撲205例,60例,脱臼は120例,12例であった, (株)アークメディア, Japanese
  • 前向き調査によるスノーボード及びスキー外傷の発生頻度の比較
    遠山 晴一, 安田 和則, 青木 喜満, 日本整形外科スポーツ医学会雑誌, 19, 1, 26, 30, Mar. 1999
    全外傷発生頻度はスノーボードでは873外傷/1,000,000時間・人,スキーでは315外傷/1,000,000時間・人と,スノーボードがスキーに比し,約2.7倍と有意に高い.スノーボードでは肩関節周囲,頭頸部・顔面,上腕・前腕,足関節・足部の外傷発生頻度が高かったのに対し,スキーでは膝関節の外傷発生頻度が圧倒的に高く,種類別にみるとスノーボードでは骨折,捻挫,打撲の発生頻度がほぼ同等に高かったのに対し,スキーでは捻挫の発生頻度が高かった, (一社)日本整形外科スポーツ医学会, Japanese
  • Gamma Nailによる骨接合術後に骨頭が回旋転位した大腿骨転子部骨折の2例
    須田 浩太, 遠山 晴一, 野村 茂治, 日本災害医学会会誌, 47, 2, 125, 129, Feb. 1999
    82歳女性と79歳女性の2例について経験した.いずれも再手術は施行せず,前者は術後1年6ヵ月で骨癒合良好であるが歩行器歩行としている.後者は1年7ヵ月で骨癒合良好で杖なし独歩可能である, (一社)日本職業・災害医学会, Japanese
  • 【膝靱帯損傷】膝十字靱帯損傷の治療
    遠山 晴一, 安田 和則, 田邊 芳恵, 理学療法, 15, 12, 978, 983, Dec. 1998
    (株)メディカルプレス, Japanese
  • 【膝靱帯損傷】膝十字靱帯損傷の理学療法
    山中 正紀, 安田 和則, 遠山 晴一, 理学療法, 15, 12, 984, 991, Dec. 1998
    (株)メディカルプレス, Japanese
  • スノーボード及びスキーによる膝関節周囲傷害 Prospective studyによる傷害発生頻度の比較               
    遠山 晴一, 東 裕隆, 杉原 進, 安田 和則, 膝, 23, 94, 97, Nov. 1998
    1)Prospective studyによりスノーボード及びスキーによる膝関節周囲傷害の発生頻度を調査し両者の傷害発生頻度を比較検討した. 2)その結果,全傷害発生頻度に関してはスノーボードの方が高いものの,膝関節捻挫,ことに前十字靱帯損傷に関しては,その発生頻度はスキーと比し,有意に低い, 日本膝関節学会, Japanese
  • in situ凍結処理した家兎膝前十字靱帯の力学的特性に対する成長因子(EGF及びTGF-β)の効果
    酒井 俊彦, 原 則行, 木村 正一, 三上 将, 遠山 晴一, 宮城 登, 金田 清志, 安田 和則, 日本臨床バイオメカニクス学会誌, 19, 553, 556, Oct. 1998
    (一社)日本臨床バイオメカニクス学会, Japanese
  • 内在細胞壊死後膝蓋腱における外在性細胞侵入阻止の影響
    遠山 晴一, 安田 和則, 金田 清志, 大野 和則, 日本臨床バイオメカニクス学会誌, 19, 547, 551, Oct. 1998
    1)ナイロンフィルターを用いて,凍結解凍処理後のウサギ膝蓋腱への外在性細胞侵入を阻止した. 2)その結果,外在性細胞侵入の阻止は内在性細胞壊死後膝蓋腱の力学強度の低下を抑止した. 3)内在性細胞壊死後の膝蓋腱力学強度の低下は内在性細胞壊死自体によるものでなく,外在性細胞の生体反応が原因であると示唆された, (一社)日本臨床バイオメカニクス学会, Japanese
  • 繰り返し引っ張り荷重下における大腿骨-再建前十字靱帯-脛骨複合体の生体工学的挙動
    山中 雅智, 安田 和則, 中野 秀昭, 遠山 晴一, 宮田 康史, 金田 清志, 日本臨床バイオメカニクス学会誌, 19, 115, 119, Oct. 1998
    80Nの初期張力は膝屈筋腱に対しては良好であっても,BTBに対する80Nの初期張力は過大である危険性が示唆された, (一社)日本臨床バイオメカニクス学会, Japanese
  • in situ凍結処理した家兎膝前十字靱帯及び膝蓋腱における力学的特性の経時的変化の差異
    酒井 俊彦, 原 則行, 木村 正一, 三上 将, 遠山 晴一, 宮城 登, 金田 清志, 安田 和則, 大野 和則, 日本臨床バイオメカニクス学会誌, 19, 557, 561, Oct. 1998
    (一社)日本臨床バイオメカニクス学会, Japanese
  • 前十字靱帯再建術後のリハビリテーションの理論と実際
    遠山 晴一, 安田 和則, 白土 修, リハビリテーション医学, 35, 5, 352, 358, May 1998
    (公社)日本リハビリテーション医学会, Japanese
  • 膝屈筋腱の骨への固定法に関する生体力学的検討 破断試験と疲労試験との比較               
    遠山 晴一, 安田 和則, 金田 清志, 膝, 22, 88, 91, Nov. 1997
    ヒト半腱様筋腱を用い,2種類の固定法に対し破断試験と疲労試験を行った.locking suture法の疲労特性はwasher法のそれに比し,有意に良好であった.一方,破断特性に関してはwasher法がlocking suture法に比し,強固であった.移植腱の骨への固定部の破断強度は必ずしも繰り返し荷重による固定部の疲労特性とは一致しなかった, 日本膝関節学会, Japanese
  • 外液中のイオン濃度が関節軟骨の引張特性に与える影響
    遠山 晴一, 安田 和則, 金田 清志, 日本臨床バイオメカニクス学会誌, 18, 281, 284, Oct. 1997
    ウシ膝関節軟骨を用い,イオン濃度が関節軟骨細胞外マトッリックスの引張特性に与える影響を検討した. 1)イオン濃度の増加に従い,細胞外マトッリックスの弾性係数は有意に減少を認めた. 2)弾性係数及びそのイオン濃度依存性はコラーゲン線維走行に依存する異方向性を有していた, (一社)日本臨床バイオメカニクス学会, Japanese
  • 移植腱のisometryが膝前十字靱帯再建術後の力学挙動に与える影響               
    遠山 晴一, 安田 和則, 金田 清志, 膝, 21, 72, 75, Nov. 1996
    1)手術時の移植腱のisometryがACL再建術後1.5年の膝安定性及び移植靱帯の引張特性に与える影響を成犬モデルを用いて検討した. 2)正常ACL95%信頼区間内のisometryを有するACL再建膝は正常膝には劣るものの,正常ACL95%信頼区間以上の不良なisometryを有する再建膝に比し,良好な膝安定性を有し,高い骨-靱帯-骨複合体の引張特性を呈していた, 日本膝関節学会, Japanese
  • 前距腓靱帯損傷に対する前方引き出し試験時の足関節の動作解析
    遠山 晴一, 安田 和則, 金田 清志, 日本臨床バイオメカニクス学会誌, 17, 445, 449, Oct. 1996
    新鮮凍結屍体標本を用いて,前方引き出し試験における至適な足関節の肢位及び荷重量を決定する為,前距腓靱帯切離前後の足関節の前後方向荷重時のkinematicsを検討した.前方引き出し力下の足関節挙動に対する前距腓靱帯切離の影響は足関節底屈10°及び20°位での低荷重域で顕著であった.したがって,前方引き出し試験は軽度底屈位で行うことが望ましく,又,低荷重の前方引き出し力で十分であることが示唆された, (一社)日本臨床バイオメカニクス学会, Japanese
  • ハンググライダーによる両側肩関節同時前方脱臼の1例
    冨田 文久, 遠山 晴一, 臨床整形外科, 31, 8, 975, 978, Aug. 1996
    (株)医学書院, Japanese
  • 不安定型橈骨遠位端骨折に対するtransulnar percutaneous pinning(TUP)による治療経験
    冨田 文久, 遠山 晴一, 三浪 明男, 日本手の外科学会雑誌, 13, 1, 47, 51, Aug. 1996
    不安定型橈骨遠位端骨折16例16手に対してtransulnar percutaneous pinningにより治療した. 1)臨床成績は良好で,X線学的評価では術直後の整復位が良好に維持されていた. 2)TUP法は早期リハビリテーションが可能で,合併症の発生が少なく有用な方法である, (一社)日本手外科学会, Japanese
  • 農作業が退行期骨粗鬆症に与える影響
    遠山 晴一, 冨田 文久, 杉原 進, 臨床整形外科, 31, 6, 705, 709, Jun. 1996
    60歳以上の女性100例にdual energy X-ray absorptiometryを用いた橈骨遠位部の骨塩計測を含む横断研究を行った.日光被曝時間に関しては,農作業従事群(n=36)が5.7±2.5時間/日,非従事群(n=64)が1.6±1.9時間/日.骨折頻度は従事群で25%,非従事群で31%.橈骨骨塩量は従事群と非従事群の間には有意差は認められなかった.骨塩量が健常女性33歳の平均値より-2.5標準偏差以下の骨塩減少を示す者は従事群72%,非従事群73%で,頻度に有意差を認めなかった.したがって,長時間の日光被曝を有する農作業従事者においても,非従事者と同様の骨粗鬆症の予防及び治療が必要である, (株)医学書院, Japanese
  • 膝靱帯損傷のリハビリテーション
    遠山 晴一, 安田 和則, 田辺 芳恵, 整形・災害外科, 39, 4, 411, 419, Mar. 1996
    金原出版(株), Japanese
  • パラグライダーによる事故とその検討
    冨田 文久, 遠山 晴一, 北海道整形外科外傷研究会会誌, 12, 119, 122, Mar. 1996
    1)ニセコアンヌプリで受傷したパラグライダー外傷の11例を調査した. 2)初心者では,技術の未熟さによる着陸時の下肢受傷が多いのに対し,競技レベル者では,風の影響を受け墜落し,体幹部外傷が多かった, 北海道整形外科外傷研究会, Japanese
  • 膝前十字靱帯再建術のための半腱様筋腱及び薄筋腱の形状計測               
    遠山 晴一, 安田 和則, 金田 清志, 膝, 20, 103, 106, Nov. 1995
    1)ヒト新鮮凍結屍体8体16膝に対して半腱様筋腱及び薄筋腱の腱性部分の長さ及び断面積の計測を行い半腱様筋腱及び薄筋腱の複数束と幅10mmの膝蓋腱の断面積の比較を行った. 2)腱性部分の長さは半腱様筋腱で235±20mm,薄筋腱は200±17mmであり,半腱様筋腱では4つ折りそして薄筋腱では3つ折りの複数束代用材料の作成が十分に可能であることが示唆された. 3)2つ折り及び3つ折りの半腱様筋腱と薄筋腱の断面積は幅10mmの膝蓋腱の断面積に比し有意に大きな値を呈していた, 日本膝関節学会, Japanese
  • 腱張力計測のためのArthroscopic force probeに関する生体力学的検討
    遠山 晴一, 安田 和則, 金田 清志, 日本臨床バイオメカニクス学会誌, 16, 143, 146, Oct. 1995
    腱の力学特性及びセンサーの接触状態がarthroscopic force probeの出力電位に与える影響を,実験学的ならびに理論的手法を用いて検討した.本研究で,arthroscopic force probeの出力電位はprobe挿入部の接触状態に著しく依存し,測定する腱自体の力学特性の影響を殆ど受けないことが明らかとなった, (一社)日本臨床バイオメカニクス学会, Japanese
  • アキレス腱皮下断裂の経皮的縫合術 Pull-out wire法               
    景浦 暁, 福田 公孝, 遠山 晴一, 北海道整形外科外傷研究会会誌, 11, 106, 110, Mar. 1995
    アキレス腱皮下断裂32例に対するワイヤーによる経皮的縫合術を検討した。術後平均4.7週のギプス固定を行い,6.4週で全荷重歩行が可能であった。良好な成績を得るためには,縫合時に腱断裂部を十分引き寄せることが重要なポイントである, 北海道整形外科外傷研究会, Japanese
  • 膝靱帯再建術の合併症と対策               
    安田 和則, 遠山 晴一, OS NOW, 9, 134, 143, Mar. 1993
    (株)メジカルビュー社, Japanese
  • 膝前十字靱帯新鮮損傷に対する一次修復術の定量的評価               
    遠山 晴一, 安田 和則, 大越 康充, 東京膝関節学会会誌, 12, 102, 105, Feb. 1992
    ACL一次修復術施行後3年以上を経過した40例に対しanterior laxityの定量的評価を含む追跡調査を行った.1) anterior laxityの左右差が健常者95%信頼区間に入る症例は脛骨剥離骨折例で63%,大腿骨付着部損傷例で27%,実質部損傷で0%であった.2)大腿骨付着部損傷および実質部断裂は急性期における一次修復術の適応はないと考えられ,脛骨剥離骨折においても一次修復術の適応は制限されると考えられた, 東京膝関節学会, Japanese
  • 頸椎屈曲損傷に対するcompression rod and hook systemを応用した後方固定術の治療経験               
    遠山 晴一, 小熊 忠教, 松野 誠夫, 北海道整形災害外科雑誌, 34, 1~2, 47, 53, Dec. 1990
    前方要素による脊髄圧迫の認められない頸椎屈曲損傷に対し,compression rod and hook systemを応用した頸椎後方固定術を施行後,4年以上経過した5例の臨床成績を調査した.手術年齢は34歳から64歳(平均49.2歳),経過観察期間は4年4ヵ月から5年8ヵ月(平均5年)であった.術前に完全麻痺を呈していた4例は,調査時,Frankelらの評価では不変であったが,残存最下位機能髄節高位では2髄節の改善を示していた.術前Frankelらの評価にてclass Bであった1例はclass Cへと改善していた.臥床期間は2.2±1.3週であった.全例が骨癒合を得,損傷椎間のsagittal plane rotationおよびtranslation (Whiteらの基準)は,術前に比し有意に改善し,調査時では術後値との間に有意差を認めなかった, 北海道整形災害外科学会, Japanese
  • 膝前十字靱帯損傷に対する一次修復術の成績 2年以上経過例の定量的評価
    遠山 晴一, 安田 和則, 青木 喜満, 臨床整形外科, 25, 7, 813, 819, Jul. 1990
    (株)医学書院, Japanese
  • 陳旧性上腕骨小結節単独骨折の2例
    遠山 晴一, 荻野 利彦, 三浪 明男, 臨床整形外科, 25, 5, 657, 660, May 1990
    (株)医学書院, Japanese
  • 人工膝関節置換術後,遅発性感染を生じ血管柄付腓骨移植による膝関節固定術を行った脛骨近位骨肉腫の一例               
    遠山 晴一, 大越 康充, 安田 和則, 骨・関節感染症, 4, 89, 91, Jan. 1990
    (一社)日本骨・関節感染症学会, Japanese
  • 膝前十字靱帯新鮮損傷に対する一次修復術の意義               
    安田 和則, 大越 康充, 遠山 晴一, 臨床スポーツ医学, 6, 12, 1347, 1354, Dec. 1989
    前十字靱帯損傷に対して一次修復術を施行した中で,追跡可能だったのは男性13膝,女性12膝で,手術時年齢は10歳から38歳まで,経過観察期間は平均3年6ヵ月である.単独損傷は14膝であった.靱帯の損傷部位別は,遠位付着部7膝,近位付着部12膝,実質部6膝である.手術方法はMarshallらの方法に準じた.術後評価でLachman test(-)例は遠位部断裂例で4膝,近位部断裂例で8膝,実質部断裂で1膝であった.前方引き出し試験の陰性例は遠位部断裂群4膝,近位部断裂群6膝,実質部断裂群2膝であった.Jerk testで陰性例は各々6膝,9膝,3膝で各群に有意差はなかった.anterior laxityの測定では実質部断裂群は他と比して有意に不良であった.現時点における一次修復術の適応は,活動性の低い若年者,特に女性例において,近位付着部部分断裂や,大骨片をつけた遠位付着部断裂であり,さらに術者が小さい侵襲で行える手術的技術を有する場合にのみ限定されると考える, (株)文光堂, Japanese
  • 遠位橈尺関節変形性関節症に続発した手指屈筋腱皮下断裂の1例
    遠山 晴一, 荻野 利彦, 三浪 明男, 臨床整形外科, 24, 10, 1241, 1244, Oct. 1989
    (株)医学書院, Japanese
  • 変形性膝関節症に対する楔状足底板を用いた保存的治療の長期臨床成績
    遠山 晴一, 安田 和則, 臨床整形外科, 24, 9, 1043, 1050, Sep. 1989
    (株)医学書院, Japanese
  • 膝前十字靱帯損傷に対する一次修復術の成績               
    遠山 晴一, 安田 和則, 青木 喜満, 北海道整形災害外科雑誌, 33, 1, 35, 42, Jun. 1989
    北海道整形災害外科学会, Japanese
  • Active Pivot Shiftに関する筋電図学的検討
    遠山 晴一, 安田 和則, 臨床整形外科, 24, 3, 307, 310, Mar. 1989
    (株)医学書院, Japanese
  • 胸椎・腰椎損傷に対するKaneda deviceを用いた前方除圧・再建術の治療成績 術後2年以上経過例の検討               
    遠山 晴一, 金田 清志, 鐙 邦芳, 東日本臨床整形外科学会雑誌, 1, 1, 33, 36, Mar. 1989
    良好な神経学的改善,後彎変形の矯正を示し,早期離床・歩行にもかかわらず86例は高い骨癒合率を得た.Transverse Fixatorの併用により,全例が骨癒合を得た, 東日本整形災害外科学会, Japanese

Books and other publications

  • 膝周囲骨切り術ー文献に基づく知識と手術手技アトラスー
    安田和則, 近藤英司, 秋山武徳, 遠山晴一, 石田知也, 小佐野 圭, 薮内康史, 青木喜満, 中山 寛, 八木知徳, 井上雅之, 小野寺智洋, 石田知也・遠山晴一 (担当:分担執筆, 範囲: 高位脛骨骨切り術の効果に関するバイオメカニクス)
    全日本病院出版会, 04 Dec. 2025, 4865198350, 296, Japanese, [Joint work]
  • 脊椎・脊髄疾患の外科
    遠山晴一, 脊椎・脊髄疾患のリハビリテーション:バクロフェン髄腔内投与療法(ITB療法)
    三輪書店, Aug. 2023, 9784895907859, xii, 442p, Japanese, [Contributor]
  • PT・OTの整形外科学
    遠山晴一, Chapter 15 膝関節および下腿
    文光堂, Nov. 2022, 9784830647024, 401p, Japanese, [Contributor]
  • PT・OTのための画像評価学テキスト               
    遠山晴一, 関節疾患の画像評価
    文光堂, Jun. 2022, 9784830645983, [Contributor]
  • 講座スポーツ整形外科学1 整形外科医のためのスポーツ医学概論               
    遠山晴一, 6章 スポーツ種目別運動器外傷・障害の特徴:持久系競技
    中山書店, Oct. 2021, [Contributor]
  • 講座スポーツ整形外科学3 下肢のスポーツ外傷・障害               
    遠山晴一, 寒川美奈, 石田知也, 鵞足炎(鵞足滑液包炎)
    中山書店, Jul. 2021, [Contributor]
  • 講座スポーツ整形外科学3 下肢のスポーツ外傷・障害               
    近藤英司, 遠山晴一, 安田和則, 前十字靱帯損傷
    中山書店, Jul. 2021, [Contributor]
  • 1336専門家による私の治療.2017-2018年度版               
    遠山 晴一, 安田 和則, 膝靱帯損傷
    日本医事新報社, Jul. 2017, [Contributor]
  • THE ANTERIOR CRUCIATE LIGAMENT: RECONSTRUCTION AND BASIC SCIENCE, 2nd Edition               
    TOHYAMA Harukazu, Growth Factors and Other New Methods for Graft Healing Enhancement, p.569-p.572
    Elsevier, 2017, [Contributor]
  • ACL Injury and Its Treatment               
    遠山 晴一, Future Challenges of Anterior Cruciate Ligament Reconstruction: Biological modulation using a growth factor application for enhancement of graft healing
    Springer Japan, 2016, [Contributor]
  • 膝靱帯手術のすべて               
    遠山 晴一, 急性期複合靱帯損傷の病態と対応
    メジカルビュー社, Mar. 2013, [Contributor]
  • 運動器の痛みプライマリケア 膝・大腿部の痛み               
    遠山 晴一, 変形性膝関節症による痛み
    南江堂, May 2012, [Contributor]
  • 運動器診療 最新ガイドライン               
    遠山 晴一, 膝ランニング障害(腸脛靱帯炎・鵞足炎)の診断・治療指針
    総合医学社, May 2012, [Contributor]
  • The Knee Joint: Surgical Techniques and Strategies               
    TOHYAMA Harukazu, Basic science of ligament healing. p. 43-p.50
    Springer, 2012, [Contributor]
  • 整形外科手術イラストレイテッド 膝関節の手術               
    遠山 晴一, 半月部分切除術
    中山書店, Sep. 2011, [Contributor]
  • 下肢のスポーツ外傷と障害               
    遠山 晴一, 検査法の流れ
    中山書店, Mar. 2011, [Contributor]
  • BIOMECHAVICS IN APPLICATIONS               
    TOHYAMA Harukazu, Application of Growth Factors for Enhancement of Mechanical Strength of Grafted Tendon Following Annterior Cruciate Ligament Reconstruction, p.83-p.100
    INTECH, 2011, [Contributor]
  • 整形外科専門医テキスト               
    遠山 晴一, 靱帯の構造・成分と修復機序 / 膝の機能解剖とバイオメカニクス
    南江堂, Jun. 2010, [Contributor]
  • カラーアトラス 膝・足の外科               
    遠山 晴一, 膝の機能解剖と生体力学
    中外医学社, Jun. 2010, [Contributor]
  • スポーツ医学実践ナビ スポーツ外傷・おその傷害の予防とその対処               
    日本医事新報社, 2009
  • OS NOW Instruction No.8 スポーツによる膝・足関節靱帯損傷の治療               
    メジカルビュ-, 2008
  • 最新整形外科学大系 1. 運動器の生物学と生体力学               
    中山書店, 2008
  • 今日の治療指針2007。私はこう治療している               
    医学書院, 2007
  • 最新整形外科学大系 17.膝関節・大腿               
    中山書店, 2007
  • 実践 すぐに役立つ膝靱帯損傷 診断・治療マニュアル               
    全日本病院出版, 2006
  • 整形外科診療実践ガイド               
    文光堂, 2006
  • 整形外科学・外傷学 改訂第7版               
    遠山 晴一, 骨・関節のバイオメカニクス / 筋・腱の機能と構造
    文光堂, May 2005, [Contributor]
  • 新OS NOW No. 28 Useful Surgical Approach―定型からオリジナルまで               
    遠山 晴一, 膝関節鏡におけるアプローチ.265頁-270頁
    メジカルビュ-, 2005, [Contributor]
  • 今日の整形外科治療指針 第5版               
    遠山 晴一, 側副靭帯損傷
    医学書院, Mar. 2004, [Contributor]

Lectures, oral presentations, etc.

Affiliated academic society

  • Oct. 2024 - Present
    Sigma Xi (The Scientific Research Honor Society)               
  • 2023 - Present
    日本スポーツ整形外科学会               
  • 2023 - Present
    日本膝関節学会               
  • 2023
    日本関節鏡・膝・スポーツ整形外科学会               
  • 日本臨床スポーツ医学会               
  • 膝関節フォーラム               
  • 北海道整形災害外科学会               
  • 日本整形外科学会               
  • 日本整形外科スポーツ医学会               
  • 米国整形外科基礎学会(ORS)               
  • 米国整形外科学会(AAOS)               
  • 国際関節鏡・膝関節外科・スポーツ医学学会(ISAKOS)               
  • 日本臨床バイオメカニクス学会               

Research Themes

  • 骨格筋他動的伸長刺激による筋力増強と栄養因子に関する分子生物学的検討
    科学研究費助成事業 基盤研究(C)
    01 Apr. 2022 - 31 Mar. 2025
    池田 聡, 千葉 春子, 遠山 晴一
    日本学術振興会, 基盤研究(C), 北海道大学, 22K11362
  • Identification of Risk Factors for Progression of Locomotive Syndrome by 3-D Gait Analysis System Using Wearable Sensors
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
    01 Apr. 2022 - 31 Mar. 2025
    遠山 晴一
    Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, 22K11441
  • Three-dimensional gait analysis using Anti-gravity treadmill after total hip replacement
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
    Apr. 2015 - Mar. 2018
    TOHRU IRIE
    We evaluated the three-dimensional gait analysis of patients who underwent total hip replacement for osteoarthritis under conditions of 50% load, 75% load, 100% load using anti-gravity treadmill. We performed the measurement preoperatively, 3 weeks postoperatively, 6 weeks postoperatively.
    At 3 weeks postoperatively, the maximum knee joint extension angle at 50% load significantly increased compared to 100% load. At 6 weeks postoperatively, the maximum hip joint flexion angle at 50% load significantly decreased compared to 100% load and the maximum knee joint extension angle at 50% load significantly increased compared to 100% load.
    The current study suggested that the rehabilitation using an anti-gravity treadmill may be effective especially at preoperatively to 3 weeks postoperatively and that this is more effective to maintain the load amount up to 75% load.
    Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, Competitive research funding, 15K10382
  • The effects of kinematics in the legs in the subjects following anterior cruciate ligament reconstruction on biomechanical function of the graft
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
    Apr. 2014 - Mar. 2016
    TOHYAMA HARUKAZU
    For safe monitoring knee kinematics of the subjects during gait shortly after ACL reconstruction, we propose a new gait analytic technique using the combination of wearable sensors-based H-Gait system and anti gravity treadmill. Our study showed that the reduction of the weight-bearing in anti-gravity treadmill significantly decrease maximum flexion angles of the hip and knee joint at the swing phase.
    We also found a significant interaction effects of gender and ACL reconstruction on valgus motion at the landing after drop jump task, while there is no significant correlation between quadriceps strength and valgus motion at the landing after drop jump task in female subjects after ACL reconstruction.
    Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, Principal investigator, Competitive research funding, 26462281
  • Regulation of Macrophage Migration Inhibitory Factor ForHealing of Tendons and Ligaments
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
    Apr. 2010 - Mar. 2013
    TOHYAMA Harukazu, YASUDA Kazunori, ONODERA Shin, KONDO Eiji
    There have been no reports that investigated the expression or the role of macrophage migration inhibitory factor (MIF) in the repair process after ligament injury. The aim of this study was to test the hypothesis that that the deficiency in MIF gene might delay medial collateral ligament (MCL) healing. The present study showed that the levels of mechanical properties and matrix metalloproteinase (MMP)-2 and -13 mRNA in the healing tissue were significantly lower in MIF gene-deficient mice (MIFKO) than in wild-type mice (WT) on day 28 after injury. Histologically, healing tissues in MIFKO exhibited prolonged hypertrophy, poor vascularity, and prolonged increase in cell number compared with those in WT. Taken together, it was suggested that MIFKO exhibited delayed healing of the MCL, which might be caused by lower mRNA expression of MMP-2 and -13.
    Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, Principal investigator, Competitive research funding, 22591673
  • Role of MIF on the process of fracture healing and the effect of its regulation
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
    Apr. 2009 - Mar. 2012
    ONODERA Shin, TOHYAMA Harukazu, YASUDA Kazunori
    We investigated the role of macrophage migration inhibitory factor (MIF) on the process of fracture healing using MIF KO mice. In MIF KO mice, the mechanical properties of the fracture callus were decreased at the early stage of fracture healing, which was caused at least in part by the delay in the calcification of osteoid or the decrease in the number of osteoclasts. These were considered to be associated with decreased mRNA expression of MMP-2, MT1-MMP, Cathepsin K, and alkaline phosphatase.
    Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, Competitive research funding, 21591909
  • Molecular biological study of the remodeling of the stress-deprived patellar tendon
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
    Apr. 2007 - Mar. 2009
    KITAMURA Nobuto, TOHYAMA Harukazu
    除負荷は整形外科的治療において不可避的に発生し、関節構成体の生体力学的特性を著しく劣化させる。本研究は、IL-1受容体アンタゴニストが除負荷された膝蓋腱コラーゲン線維束自体には影響を与えず、コラーゲン線維束間の力学的相互作用、コラーゲン線維束と他のマトリックス成分間の力学的相互作用に影響を与えることを示唆した。また、除負荷により膝蓋腱線維芽細胞に過剰発現したサイトカインを制御することにより力学的強度の減少を抑制できる可能性を明らかにした。
    Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, Competitive research funding, 19591748
  • Multidisciplinary study on the regulation of the remodeling of the patellar tendon matrix in response to mechanical environment
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
    Apr. 2006 - Mar. 2009
    TOHYAMA Harukazu, YASUDA Kazurori, ONODERA Shin, KONDO Eiji
    廃用がもたらす除負荷は腱組織の力学特性を低下させることが知られているが、この機序や制御に関しては不明であった。本研究ではin vivo動物モデルを用い、除負荷が膝蓋腱細胞におけるIL-1β発現を亢進させ、IL-1抑止は除負荷膝蓋腱の力学特性を改善させることを明らかにし、廃用による腱組織の力学的劣化には炎症性サイトカインが重要な役割を担い、本サイトカイン制御により廃用がもたらす腱の力学的劣化を抑止する可能性を示した。
    Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hokkaido University, Principal investigator, Competitive research funding, 18390406
  • The effect of cell-based therapy with autologous synovial fibroblasts activated by exogenous TGF-beta1 on the in situ frozen-thawed anterior cruciate ligament
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
    Apr. 2006 - Mar. 2008
    KONDO Eiji, YASUDA Kazunori, TOHYAMA Harukazu
    Purpose
    The present study was conducted to clarify the effect of cell therapy with autologous synovial tissue-derived fibroblasts activated by transforming growth factor (TGF)-betal on the necrotized anterior cruciate ligament (ACL).
    Materials and Methods
    Thirty-six mature female Japanese White rabbits were used in this study. In Group I, the fibrin glue with autologous synovial tissue-derived fibroblasts after TGF-beta stimulation was wrapped around the necrotized ACL after the freeze-thaw treatment. In Group II, the one without TGF-beta stimulation was wrapped around the frozen-thawed ACL. In Group III, the fibrin glue without fibroblasts was applied in the same manner on the frozen-thawed ACL.
    Results
    Histological observation found that implantation of fibroblasts after TGF-beta stimulation accelerated cellular infiltration into the ACL following fibroblast necrosis. Biomechanically, the transplantation of synovial tissue-derived autologous fibroblasts activated by TGF-beta inhibited mechanical deterioration of the ACL after the freeze-thaw treatment.
    Discussion
    The present study has shown that the cell-based therapy using synovial tissue-derived fibroblasts activated by TGF-beta1 is one of possible solutions against mechanical deterioration of the graft after ACL reconstruction.
    Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), HOKKAIDO UNIVERSITY, Competitive research funding, 17591543
  • Clarification of Mechanism of the Tendon/Ligament Matrix Remodeling Induced by Various Mesenchymal Cells and Its Molecular Control
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
    Apr. 2004 - Mar. 2007
    YASUDA Kazunori, TOHYAMA Harukaz, SHIMIZU Hiroshi, ONODERA Shin
    1)Stress deprivation significantly enhanced gene expression of Mn-SOD, Tyrosinase-related protein, KIAA1199-related protein, KIAA1199, and PDGFR-alpha in fibroblasts in the patellar tendon. In addition, Mn-SOD was over-expressed in vivo at both the m-RNA and protein levels. Stress deprivation also significantly enhanced expression of Expression of IL-1beta, TNF-alpha, and TGF-beta in the patellar tendon, while it provided no significant effects to expression of PDGF-B and bFGF. In fibroblasts of the grafted tendon, VEGF was over-expressed at 2 weeks and showed a peak at 3 weeks.
    2)The proliferation rate of extrinsic fibroblasts (EFs) derived from the tendon tissue was significantly lower was significantly lower than that of intrinsic fibroblasts (IFs) in the tendon. The infiltrative rate was significantly higher in EFs than in IFs on 10 to 14 days after cell culture. Ex vivo infiltration of both fibroblasts into the patellar tendon significantly reduced the mechanical properties of fascicles from the tendon.
    3)An application of TGF-beta1 significantly reduced the deterioration of mechanical properties of the patellar tendon caused by stress deprivation, while an application of anti-TGF-beta antibody significantly enhanced the degradation. Concerning the in situ frozen-thawed anterior cruciate ligament and the grafted patellar tendon, the TGF-beta1 application did not show' any significant effects. Regarding a fibrous tissue regenerated in a defect created in the patellar tendon, the TGF-beta1 application significantly increased the mechanical properties. An application of VEGF to the in situ frozen-thawed ACL significantly enhanced vascular regeneration, while it did not significantly affect the mechanical properties.
    4)An application of synovial tissue-derived cells cultured in TGF-beta1-suplimented medium significantly increased the mechanical properties of the grafted tendon in ACL reconstruction and the fibrous tissue regenerated in a defect created in the patellar tendon.
    Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Hokkaido University, Competitive research funding, 16390425
  • THE SIGNIFICANCE OF GENE EXPRESSION IN EXTRINSIC FIBROBLASTS IN THE REMODELING OF THE TENDON MATRIX
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
    Apr. 2004 - Mar. 2006
    TOHYAMA Harukazu, YASUDA Kazunori, SHIMIZU Hiroshi
    1.PURPOSE
    To clarify the role of collagen production and cytokine expression in extrinsic fibroblasts in the remodeling of the tendon matrix after fibroblast necrosis.
    2.METHODS
    Using the rat model, we examined type-III collagen expression in the patellar tendon after the in situ freeze-thaw treatment by RT-PCR and immunohistology. We also examined local expression of IL-1beta,PDGF-BB, and TGF-betal in fibroblasts infiltrating the rat frozen-thawed patellar tendon using immunohistological observation and compared the responses to IL-1beta,PDGF-BB, and TGF-beta1 between the extrinsic fibroblasts infiltrating the rat frozen-thawed patellar tendon which simulates an idealized patellar tendon graft and the normal tendon fibroblasts concerning gene expression of matrix metalloproteinase (MMP)-13 and types I and III collagen using Northern blot analysis.
    3.RESULTS
    Analysis by RT-PCR showed that the expression level of type III procollagen mRNA in the frozen-thawed tendon was significantly higher than that in the sham-operated tendon at 6 and 12 weeks. Immunohistological findings showed positive type III collagen staining around cells that had infiltrated the necrotized tendon at 3,6, and 12 weeks. The immunohistological findings revealed that IL-1beta was over-expressed in extrinsic fibroblasts that infiltrate the patellar tendon 2 and 6 weeks after the in situ freeze-thaw procedure, although PDGF-BB or TGF-beta1 was not over-expressed in these extrinsic fibroblasts. Northern blot analysis of the present study showed that fibroblasts derived from the patellar tendon 6 weeks after the in situ freeze-thaw procedure exhibited a less response to IL-1beta than normal tendon fibroblasts in respect to MMP-13 mRNA regulation.
    4.CONCLUSIONS
    The present study indicated that type-III collagen and IL-1beta have a function with a close relationship to matrix remodeling of the tendon after necrosis, besides the commencement of inflammation during the tissue healing process.
    Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), HOKKAIDO UNIVERSITY, Principal investigator, Competitive research funding, 16591468
  • Microbiomechanical studies on biological tissue/cell interaction and remodeling
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)
    Apr. 2003 - Mar. 2006
    HAYASHI Kozaburo, YASUDA Kazunori, TOHYAMA Harukazu, MIYAZAKI Hiroshi, DEGUCHI Shinji
    1.Effects of Growth, Maturation, and Blood Pressure and Flow Change on Vascular Wall Remodeling
    Common carotid arteries harvested from Wistar rats aged 8 to 64 weeks were used for biomechanical, morphological, and histological studies. Blood flow, pressure, wall thickness, and wall circumferential elastic modulus increased with age ; however, the composition of connective tissues remained unchanged. DOCA-salt hypertension increased wall thickness so as to maintain wall stress at constant, and increased elastic modulus and vascular contractility being accompanied with smooth muscle cell hypertrophy. Similar phenomena were also observed in venous wall. Blood flow changes under hypertension did not affect wall shear stress. These changes did not correlate with the changes in connective tissue composition. Collagen cross-linking has some relation with the changes of wall mechanical properties induced by aging and hypertension.
    2.Effects of Growth and Maturation, and Stress Deprivation and Restressing on the Mechanical Properties of Healing Patellar Tendons
    A rectangular defect having the width of 1/3 of the width of the patellar tendon was made in the mature rabbit knee, and then a stress shielding technique was applied to the tendon for removing stress during healing. Stress deprivation greatly suppressed and delayed the increase of strength of the tissue regenerated in the defect and also markedly reduced the strength of the residual tissue. Restressing after stress shielding rapidly increased the strength of both tissues, although iit was not recovered to normal level even after a prolonged period of time, implying that stress shielding gives very adverse effects on healing tissues. Effects of growth factors on tissue healing and mechanical properties of collagen fascicles were also studied.
    3.Effects of Activity Changes on the Structure and Mechanical Properties of Cancellous Bone
    The amount and hardness of cancellous bone were significantly reduced by immobilization ; they were recovered by remobilization, although it took much time. Physical exercise increased the hardness of cancellous and cortical bone, and its quitting returned the hardness to normal more quickly in cancellous bone.
    4.Mechanical Properties of Cells
    New techniques were developed for the determination of the mechanical properties of cells.
    Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (A), Competitive research funding, 15200036
  • Comprehensive Analysis for the Effect of Facet Joint Immobilization on Intervertebral Disc at the Adjacent Motion-Segment
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
    Apr. 2002 - Mar. 2005
    SHIRADO Osamu, WATANABE Yasuyuki, YASUDA Kazunori, TOYAMA Harukazu
    The purpose of this study was to comprehensively evaluate the effect of facet joint immobilization on intervertebral disc at the immobilized and adjacent motion-segments. This study was divided into three parts ; Biomechanical and immunohistological study using live rabbit model (Study I), biomechanical study using calf lumbar spine (Study II), computational analysis using finite element method (FEM) model (Study III), and clinical cohort study on the patients with lumbar degenerative diseases that were treated conservatively and surgically (Study IV). In the Study I, Japanese white rabbits were utilized to develop the experimental model with completely immobilized facet joint. Three, six and twelve months after the surgery with immobilization, the intervertebral discs at the immobilized and adjacent motion-segments were analyzed biomechanically and immunohistologically. The disc at the adjacent motion-segment got more degenerated, and the rigidity significantly decreased, compared with the disc in the control and sham group. In the study II, the less rigid instrumentation provided favorable results to reduce the stress at the disc adjacent to the immobilized segment. In the Study III, it proved that a novel spinal instrumentation with a certain flexibility can be developed to successfully stabilize unstable motion-segments. In the Study IV, it became evident that there were a number of patients who need to prevent or avoid the spinal arthrodesis.
    The further study concentrating on molecular biology is mandatory to more understand the mechanism of disc degeneration on the segment adjacent to the immobilized segment. We have future plan on the development of a novel technique preventing and managing the disc degeneration adjacent to the immobilized segment.
    Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Competitive research funding, 14571353
  • THE ROLE OF EXTRINSIC INFROBLASTS IN THE RTEMODELING OF THE PATELLAR TENDON MATRIX
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
    Apr. 2002 - Mar. 2004
    TOHYAMA Harukazu, MAJIMA Tokifumi, NISHIHIRA Jun, YASUDA Kazunori
    Methods :
    1)Japanese White rabbits were divided into four groups.
    2)In Group I, the right patellar tendon underwent the in situ freeze-thaw treatment with liquid nitrogen to kill intrinsic fibroblasts of the patellar tendon and the wrapping treatment with nylon membrane filters to inhibit extrinsic cell infiltration from surrounding tissues into the patellar tendon. In Group II, the patellar tendon underwent the same wrapping treatment without the freeze-thaw treatment. In Group III, the right patellar tendon underwent the freeze-thaw treatment without the wrapping treatment.
    3)In each group, rabbits were sacrificed at 1,3 and 6 weeks postoperatively, and examined histologically and mechanically.
    Results :
    1)Histologically, no cells were found in the midsubstance of the patellar tendon in the Group I until 6 weeks after treatment. The patellar tendons in the Group II appeared normal until 6 weeks. In the Group III, no cells were found in the midsubstance at 1 week. Many cells were dispersed throughout the patellar tendon of the patellar tendon at 6 weeks.
    2)Mechanically, there were no significant differences between the Groups I and II, although the elastic modulus and the tensile strength of the Group I were slightly lower than those of the Group II at 6 weeks. In the Group III, the elastic modulus and the tensile strength of the patellar tendon were significantly lower than those of the Groups I and II.
    Conclusion :
    This study revealed that the inhibition of extrinsic cell infiltration by the wrapping treatment prohibited the reduction in mechanical properties of the patellar tendon that occurred following intrinsic cell necrosis, at least, until 6 weeks. These facts suggest that biological activities of extrinsic cells may reduce the mechanical properties of the patellar tendon matrix following intrinsic cell necrosis.
    Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), HOKKAIDO UNIVERSITY, Principal investigator, Competitive research funding, 14571351
  • The effect of initial graft tension on biomechanical and plastic properties of the knee with ACL reconstruction using cyclic loading
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
    Apr. 2001 - Mar. 2003
    YAMANAKA Masanori, TOHYAMA Harukazu, WADA Tatuhiko, YASUDA Kazunori
    Initial graft tension influences clinical results of anterior cruciate ligament reconstruction. Under repetitive loading conditions, the effect of initial graft tension on the biomechanical behavior of the femur-graft-tibia complex may depend on the graft and the fixation. After anterior cruciate ligament reconstruction, initial graft tension of 20, 80, or 140 N was applied to the complex for 2 minutes. Then, a cyclic force-relaxation test was performed for 5000 cycles so that the graft was stretched by 2 mm. In a patellar tendon graft with interference screws, the average peak load values at the 5000th cycle were 105, 157, and 205 N for the complexes with initial tension of 20, 80, and 140 N, respectively. In a flexor tendon graft with interference screws, the values were 27, 41, and 39 N. In a flexor tendon graft with Endobutton fixation, the values were 17, 40, and 77 N. Considering the tension of the normal anterior cruciate ligament (16 to 87 N), an initial tension of 20 N appears to be high enough for a patellar tendon graft. For a flexor tendon graft with interference screws, an increase in initial tension above 80 N has no biomechanical advantages.
    Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), HOKKAIDO UNIVERSITY, Competitive research funding, 13680920
  • THE EFFECT OF INTRINSIC FIBROBLASTS ON REMODELING OF PATELLAR TENDON MATRIX IN RESPONSE TO OVER- STRESSING
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
    Apr. 2001 - Mar. 2003
    AOKI Yoshimitsu, TOHYAMA Harukazu, YASUDA Kazunori
    Methods :
    1) Japanese White rabbits were divided into four groups.
    2) In Group 1, the patellar tendon underwent the in situ freeze-thaw treatment to kill intrinsic fibroblasts of the patellar tendon and the patellar tendon underwent the wrapping treatment with nylon membrane filters to inhibit extrinsic cell infiltration.
    3) In Group 2, the medial and lateral portions of the frozen-thawed patellar tendon were resected to enhance the stress, and then the central two-thirds of the patellar tendon underwent the wrapping treatment.
    4) In Group 3, the patellar tendon without the freeze/thaw treatment underwent the wrapping treatment.
    5) In Group 4, the patellar tendon was narrowed and wrapped in the same manner.
    6) All rabbits were killed at 6 weeks after surgery. We examined the in situ frozen-thawed patellar tendon at 6 weeks after the treatment, biomechanically and histologically.
    Results :
    1) The elastic modulus and the tensile strength of the patellar tendon in Group 2 were significantly less than those in Group 1, while we could not find any significant differences in these parameters between Groups 3 and 4.
    2) Histologically, no fibroblasts were observed in Groups 1 and 2, while fibroblasts were found in Groups 3 and 4.
    Conclusion:
    This study revealed that stress enhancement decreases the elastic modulus and the tensile strength of the extracellular matrix of the patellar tendon and that intrinsic fibroblasts prohibit the detrimental effect of stress enhancement on mechanical properties of the patellar tendon.
    Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), HOKKAIDO UNIVERSITY, Competitive research funding, 13671480
  • Integrated Analyses on adaptation and control mechanisms in remodeling of the extracellular matrix in the in situ frozen-thawed anterior cruciate ligament
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
    Apr. 2000 - Mar. 2003
    YASUDA Kazunori, MIYAGI Noboru, TOHYAMA Harukazu
    1. This study biomechanically and molecular-biologically clarified the remodeling phenomenon of the patellar tendon (PT) and anterior cruciate ligament (ACL) tissues from the viewpoint of collagen synthesis and metabolism controlled by growth factors, using the in situ freeze-thaw treatment and several unique animal models which were originally developed by us. The results were shown as follows : (1) Intrinsic fibroblast necrosis did not significantly affect the mechanical properties of the PT, at least, for 6 weeks, but extrinsic fibroblast infiltration affected them. In addition, both stress deprivation and enhancement significantly deteriorated the mechanical properties of the in situ frozen ACL. (2) In the situ frozen PT, type-III procollagen mRNA was overexpressed in the extrinsic cells at 6 and 12 weeks, and type-III collagen was expressed around the extrinsic cells. (3) Application of IL-1beta and PDGF-BB enhanced expression of the collagenase mRNA in the extrinsic fibroblasts in the frozen PT, while application of TGF-beta inhibited it. (4) Stress deprivation in the tendon tissue simultaneously induced not only overexpression of IL-1beta and TGF-beta-in fibroblasts but also reduction of the mechanical properties of the extracellular matrix. (5) A low-dose of TGF-β1 and EGF applied to the frozen-thawed ACL at 0 and 3 weeks inhibitd the material deterioration caused by freezing, but the same dose application at 6 weeks did not inhibit it. A high dose application did not inhibit it at each period. (6) Application of TGF-beta improves the material properties of healing tissue in the injured ACL, but application of the PDGF-BB does not have any effects.
    2. In addition, this study established a new integrated analysis system to clarify adaptation and control mechanisms in remodeling of the tendon and ligament tissue, using the biomechanical and molecular-biological methods. As to clinical relevance, this study demonstrated a basic principle of therapeutic trials to inhibit the deterioration of the material properties of the grafted tendon and ligament tissues, which is a significant clinical problem at the present time. We believe that this principle will contribute development of gene therapy and tissue engineering-based treatment for the injured tendon and ligament tissues in the field of orthopaedic surgery and sports medicine.
    Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), HOKKAIDO UNIVERSITY, Competitive research funding, 12470299
  • BIOMECHANICAL COMPARISON BETWEEN EFFECTS OF STRESS-ENHACEMENT AND STRESS-DEPERIVATION ON REMODELING OF PATELLAR TENDONS AFTER THE IN-SITU FREEZE-THAW TREATMENT
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
    Apr. 2000 - Mar. 2002
    TOHYAMA Harukazu, YASUDA Kazunori
    1. Effects of Inhibition Extrinsic Cell Infiltration on Patellar Tendons After Intrinsic Fibroblast Necrosis : We analyzed the effect of inhibition of extrinsic cell infiltration on mechanical properties of the patellar tendon after intrinsic fibroblast necrosis using 72 rabbits. As a result, the inhibition of extrinsic cell infiltration prohibited the reduction in mechanical properties of the patellar tendon that occurred following intrinsic cell necrosis.
    2. Effects of Stress Enhancement on the Mechanical Properties of in situ Frozen Patellar Tendons : A biomechanical study was conducted to clarify the effect of stress enhancement on the mechanical properties of the in situ frozen-thawed patellar tendons using 30 rabbits. As a result, excessively high stress reduced the mechanical properties of the frozen-thawed patellar tendon.
    3. Effects of the Presence Intrinsic Fibroblasts or Extrinsic Infiltrating Cells on the Mechanical Properties of the Extracellular Matrix in the Stress-enhanced Patellar Tendon A study was conducted to determine the effect of the presence of intrinsic fibroblasts or extrinsic infiltrating cells on the extracellular matrix of the stress-enhanced patellar tendon using 48 rabbits. As a result, intrinsic fibroblasts prohibited detrimental effects of stress enhancement on mechanical properties of the patellar tendon and extrinsic infiltrating cells increased the cross-sectional area of the patellar tendon.
    4. Biomechanical Comparison between Effects of Stress-enhancement and Stress-deprivation on Mechanical Properties of Frozen-thawed Paterllar Tendons : We compared effects of stress-enhancement on mechanical properties of the frozen-thawed patellar tendon to those of stress-deprivation in a rabbit model. As results, stress-deprivation rapidly deteriorated mechanical properties of the frozen-thawed patellar tendon, while stress-enhancement gradually deteriorated them.
    5. Conclusions : This project has revealed that effects of stress-enhancement on mechanical properties of the frozen-thawed patellar tendon are different from those of stress-deprivation, and that biological responses of extrinsic infiltrating cells contribute to mechanisms of these effects.
    Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), HOKKAIDO UNIVERSITY, Principal investigator, Competitive research funding, 11680830
  • MECHANISM OF REMODELING PHENOMENON INDUCED BY FUNCTIONAL ADAPTATION OF THE IN-SITU FROZEN-THAWED PATELLAR TENDON
    Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
    Apr. 2000 - Mar. 2002
    TOHYAMA Harukazu, ITHO Hiroshi, AOKI Yoshimitu, YASUDA Kazunori
    1. Methods:
    (1) For 55 Wistar rats (14-week-old), the right patellar tendon underwent the in situ freeze-thaw treatment to necrotize intrisic fibrblasts of the tendon and the left knees underwent the sham-operation in order to test the hypothesis that extrinsic cells which infiltrate in the necrotized patellar tendon synthesize type-III.
    (2) We examined the in situ frozen-thawed patellar tendon at 2 to 12 weeks after the treatment with immunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR) and mechanical evaluations. We also evaluated the effect of the in situ freeze-thaw treatment on viability of instrinsic fibroblasts using a tissue-culture technique.
    2. Results:
    (1) Tissue culture showed that no cell outgrowth was observed from all explants of the tendons after the freeze-thaw treatment, while fibroblast outgrowth was observed from 83.0 % of the explants in the non-treated tendon.
    (2) Immunohistochemical findings showed that positive type-III collagen staining was observed around the extrinsic cells which infiltrate in the necrotized tendon at 3,6, and 12 weeks.
    (3) In addition, RT-PCR analysis showed that the expression level of type-III procollagen mRNA in the frozen-thawed tendon was significantly higher than that in the sham-operated tendon at 6 and 12 weeks.
    (4) Mechanical evaluations confirmed that the cross-sectional area of the in situ frozen-ghawed tendon at 6 weeks was significantly greater than that of the sham-operated tendon, while its elastic modulus was significantly lower that that of the sham-operated tendon.
    3. Conclusion: This study suggested that extrinsic cells which infiltrated in the necrotized patellar tendon synthesize type-III collagen in the physiological mechanical environment. The present study indicated that the increase of type-III collagen in the tendon graft is unavoidable, even if we can avoid depriving the graft of stress.
    Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), HOKKAIDO UNIVERSITY, Principal investigator, Competitive research funding, 12671389
  • 力学的ストレスが腱組織の線維芽細胞と細胞外マトリックスに与える影響の機序の解明               
    1999
    Competitive research funding
  • The effects of mechanical stress on biological response of tendon fibroblasts and extracellular matrix of the tendon tissues               
    1999
    Competitive research funding

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  • 応用社会行動科学, 2024年, 修士課程, 医学院
  • 運動器障害学演習, 2024年, 修士課程, 保健科学院
  • 運動器障害学特論, 2024年, 修士課程, 保健科学院
  • 大学院共通授業科目(教育プログラム):JICA開発大学院連携プログラム, 2024年, 修士課程, 大学院共通科目
  • 先端リハビリテーション科学特講, 2024年, 博士後期課程, 保健科学院
  • 先端リハビリテーション科学特講演習, 2024年, 博士後期課程, 保健科学院
  • 義肢装具学Ⅰ, 2024年, 学士課程, 医学部
  • 臨床実習Ⅴ(理), 2024年, 学士課程, 医学部
  • 老年健康障害論, 2024年, 学士課程, 医学部
  • 臨床実習Ⅲ(理), 2024年, 学士課程, 医学部
  • 臨床実習Ⅱ(理), 2024年, 学士課程, 医学部
  • 保健生理学, 2024年, 学士課程, 医学部
  • リハビリテーション概論, 2024年, 学士課程, 医学部
  • 内部障害学, 2024年, 学士課程, 医学部
  • 成人健康障害論, 2024年, 学士課程, 医学部
  • 運動器障害学, 2024年, 学士課程, 医学部
  • 疾患病態学概論, 2024年, 学士課程, 医学部
  • 臨床実習Ⅲ(理), 2024年, 学士課程, 医学部
  • 臨床実習Ⅳ(理), 2024年, 学士課程, 医学部
  • リハビリテーション生理学, 2024年, 学士課程, 医学部
  • 理学療法研究法演習Ⅰ, 2024年, 学士課程, 医学部
  • 理学療法研究法演習Ⅱ, 2024年, 学士課程, 医学部
  • 臨床実習Ⅰ(理), 2024年, 学士課程, 医学部
  • 臨床実習Ⅱ(理), 2024年, 学士課程, 医学部
  • 一般教育演習(フレッシュマンセミナー), 2024年, 学士課程, 全学教育
  • リハビリテーション解剖学Ⅱ, 2024年, 学士課程, 医学部
  • リハビリテーション医学, 2024年, 学士課程, 医学部