Dec. 2019, International Parkinson and Movement Disorder Society, 2019 Travel Grant Award　　　　　　　　　　　　　　　
Functional Limits of Stability and Standing Balance in People with and without Freezing of Gait
Naoya Hasegawa

Sep. 2013, 日本健康行動科学会第12回学術大会, 大会長優秀発表賞　　　　　　　　　　　　　　　
感覚フィードバックの違いが動的バランスの運動学習に与える影響について
長谷川 直哉

Effect of Difference of Sensory Modality in Cognitive Task on Postural Control During Quiet Stance.
Yusuke Sakaki, Naoya Hasegawa, Ami Kawata, Hiromasa Akagi, Minori Sawada, Hiroki Mani
Sensors (Basel, Switzerland), 25, 4, 19 Feb. 2025, [Peer-reviewed], [Corresponding author], [International Magazine]
English, Scientific journal, Cognitive loads impact postural control; however, the specific influence of sensory modalities employed in cognitive tasks during motor-cognitive dual tasks remains unclear. This study investigated the distinct effects of visual and auditory cognitive tasks on static postural control while controlling for differences in task content. Twenty-five healthy young adults were instructed to maintain a quiet stance on a force plate under three cognitive task conditions: a single motor task (control), a paced visual serial addition task (visual), and a paced auditory serial addition task (auditory). Center of pressure (COP) displacements were measured, and both linear (e.g., sway area) and non-linear assessments of postural control were analyzed. Results revealed a significant reduction in sway area during cognitive tasks compared to the control condition. However, under the auditory condition, the power spectrum density of COP displacements in the moderate frequency band was significantly higher than those in the control and visual conditions, accompanied by a notable increase in the mean power frequency. These findings suggest that auditory cognitive load exerts a more significant effect on postural control than visual cognitive load during motor-cognitive dual tasks. This highlights the relevance of sensory modalities in cognitive loads for effective fall-risk assessment., 48490980

Editorial: Postural control priorities and effective motor learning
Tadayoshi Asaka, Yoshiro Okubo, Naoya Hasegawa
Frontiers in Human Neuroscience, 18, Frontiers Media SA, 09 Jan. 2025, [Peer-reviewed], [Invited], ［Internationally co-authored］, [International Magazine]
Scientific journal

Underlying control of balance
Naoya Hasegawa, Hiroki Mani
Gait, Balance, and Mobility Analysis, 39, 58, Elsevier, 2025, [Invited], [Lead author], [International Magazine]
In book

Fear among patients with Parkinson's disease and repeated falls: Analysis of skin conductance responses during simulated accidents
Yasuomi Tomii, Mika Otsuki, Daisuke Sawamura, Naoya Hasegawa, Yousuke Tanaka, Youhei Kawamura
Parkinsonism & Related Disorders, 107197, 107197, Elsevier BV, Nov. 2024, [Peer-reviewed], [International Magazine]
Scientific journal

Digital measures of freezing of gait across the spectrum of normal, non-freezers, possible freezers and definite freezers.
Martina Mancini, Naoya Hasegawa, Daniel S Peterson, Fay B Horak, John G Nutt
Journal of neurology, 270, 9, 4309, 4317, Sep. 2023, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
English, Scientific journal, Over the course of the disease, freezing of gait (FoG) will gradually impact over 80% of people with Parkinson's disease (PD). Clinical decision-making and research design are often based on classification of patients as 'freezers' or 'non-freezers'. We derived an objective measure of FoG severity from inertial sensors on the legs to examine the continuum of FoG from absent to possible and severe in people with PD and in healthy controls. One hundred and forty-seven people with PD (Off-medication) and 83 healthy control subjects turned 360° in-place for 1 minute while wearing three wearable sensors used to calculate a novel Freezing Index. People with PD were classified as: 'definite freezers', new FoG questionnaire (NFOGQ) score > 0 and clinically observed FoG; 'non-freezers', NFOGQ = 0 and no clinically observed FoG; and 'possible freezers', either NFOGQ > 0 but no FoG observed or NFOGQ = 0 but FoG observed. Linear mixed models were used to investigate differences in participant characteristics among groups. The Freezing Index significantly increased from healthy controls to non-freezers to possible freezers and to definite freezers and showed, in average, excellent test-retest reliability (ICC = 0.89). Unlike the Freezing Index, sway, gait and turning impairments were similar across non-freezers, possible and definite freezers. The Freezing Index was significantly related to NFOG-Q, disease duration, severity, balance confidence, and the SCOPA-Cog (p < 0.01). An increase in the Freezing Index, objectively assessed with wearable sensors during a turning- in-place test, may help identify prodromal FoG in people with PD prior to clinically-observable or patient-perceived freezing. Future work should follow objective measures of FoG longitudinally.

Effects of the Loss of Binocular and Motion Parallax on Static Postural Stability.
Keita Ishikawa, Naoya Hasegawa, Ayane Yokoyama, Yusuke Sakaki, Hiromasa Akagi, Ami Kawata, Hiroki Mani, Tadayoshi Asaka
Sensors (Basel, Switzerland), 23, 8, 20 Apr. 2023, [Peer-reviewed], [Invited], [Corresponding author], [International Magazine]
English, Scientific journal, Depth information is important for postural stability and is generated by two visual systems: binocular and motion parallax. The effect of each type of parallax on postural stability remains unclear. We investigated the effects of binocular and motion parallax loss on static postural stability using a virtual reality (VR) system with a head-mounted display (HMD). A total of 24 healthy young adults were asked to stand still on a foam surface fixed on a force plate. They wore an HMD and faced a visual background in the VR system under four visual test conditions: normal vision (Control), absence of motion parallax (Non-MP)/binocular parallax (Non-BP), and absence of both motion and binocular parallax (Non-P). The sway area and velocity in the anteroposterior and mediolateral directions of the center-of-pressure displacements were measured. All postural stability measurements were significantly higher under the Non-MP and Non-P conditions than those under the Control and Non-BP conditions, with no significant differences in the postural stability measurements between the Control and Non-BP conditions. In conclusion, motion parallax has a more prominent effect on static postural stability than binocular parallax, which clarifies the underlying mechanisms of postural instability and informs the development of rehabilitation methods for people with visual impairments., 31407822

Editorial: Advances in rehabilitation for motor symptoms in neurodegenerative disease.
Hiroshi Kataoka, Akiyoshi Matsugi, Yasutaka Nikaido, Naoya Hasegawa, Tsubasa Kawasaki, Yohei Okada
Frontiers in human neuroscience, 17, 1107061, 1107061, 2023, [Peer-reviewed], [International Magazine]
English

Effects of a Cognitively Challenging Agility Boot Camp Program on Balance and Gait in People With Parkinson's Disease: Does Freezing of Gait Status Matter?
Vrutangkumar V Shah, Rodrigo Vitorio, Naoya Hasegawa, Patricia Carlson-Kuhta, John G Nutt, Laurie A King, Martina Mancini, Fay B Horak
Neurorehabilitation and neural repair, 15459683221119757, 15459683221119757, 25 Aug. 2022, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
English, Scientific journal, BACKGROUND AND AIM: Individuals with Parkinson's disease (PD) with and without freezing of Gait (FoG) may respond differently to exercise interventions for several reasons, including disease duration. This study aimed to determine whether both people with and without FoG benefit from the Agility Boot Camp with Cognitive Challenges (ABC-C) program. METHODS: This secondary analysis of our ABC-C trial included 86 PD subjects: 44 without FoG (PD-FoG) and 42 with FoG (PD + FoG). We collected measures of standing sway balance, anticipatory postural adjustments, postural responses, and a 2-minute walk with and without a cognitive task. Two-way repeated analysis of variance, with disease duration as covariate, was used to investigate the effects of ABC-C program. Effect sizes were calculated using standardized response mean (SRM) for PD-FoG and PD + FoG, separately. RESULTS: The ABC-C program was effective in improving gait performance in both PD-FoG and PD + FoG, even after controlling for disease duration. Specifically, dual-task gait speed (P < .0001), dual-cost stride length (P = .012), and these single-task measures: arm range of motion (P < .0001), toe-off angle (P = .005), gait cycle duration variability (P = .019), trunk coronal range of motion (P = .042), and stance time (P = .046) improved in both PD-FoG and PD + FoG. There was no interaction effect between time (before and after exercise) and group (PD-FoG/PD + FoG) in all 24 objective measures of balance and gait. Dual-task gait speed improved the most in PD + FoG (SRM = 1.01), whereas single-task arm range of motion improved the most in PD-FoG (SRM = 1.01). CONCLUSION: The ABC-C program was similarly effective in improving gait (and not balance) performance in both PD-FoG and PD + FoG.

Visual feedback in the lower visual field affects postural control during static standing
Hiroki Mani, Norio Kato, Naoya Hasegawa, Yuto Urano, Takumi Aiko, Takaki Kurogi, Tadayoshi Asaka
Gait & Posture, Elsevier BV, Jul. 2022, [Peer-reviewed], [International Magazine]
Scientific journal

Factors Contributing to Repeated Falls in Patients with Parkinson’s Disease: Focusing on Falls Self-efficacy and Cognition of Punishment
冨居泰臣, 冨居泰臣, 大槻美佳, 長谷川直哉
高次脳機能研究, 42, 1, Mar. 2022, [Peer-reviewed], [Last author], [Domestic magazines]
Japanese

Motor learning on postural control using auditory biofeedback training
Naoya Hasegawa, Tadayoshi Asaka
Impact, 2021, 8, 55, 57, Science Impact, Ltd., 28 Oct. 2021, [Lead author], ［Internationally co-authored］, [International Magazine]
English, Scientific journal, Motor disorders are characterised by damage to the central nervous system, which subsequently affects muscles, motor skills and brain function. People with motor disorders can suffer injury as a result of falls and recovery from falls can be challenging. Augmented biofeedback modalities
is an important tool used in physical therapy, providing individuals with biofeedback that helps guide them through the therapy. Biofeedback modalities have been designed for most of our senses, including auditory, visual and haptic and advances in technology have meant that biofeedback therapy
can make use of wearable technology and future advances are expected to further assist. Therefore, it will be key to determine which biofeedback method works best for different training exercises and conditions in order to maximise the benefits of technological advances. Dr Naoya Hasegawa
and Professor Tadayoshi Asaka are investigating which biofeedback method works best for different therapies. Their goal is to understand the characteristics of sensory modalities used for biofeedback training in order to help physical therapists determine appropriate approaches for different
individuals. The researchers are currently investigating postural control with a view to defining the characteristics of postural control during walking and standing and developing new methods to enhance or improve it. This work involves the use of force plates, 3D motion analysis systems
and electromyograms., 13888646

Development of the Relationships Among Dynamic Balance Control, Inter-limb Coordination, and Torso Coordination During Gait in Children Aged 3–10 Years
Hiroki Mani, Saori Miyagishima, Naoki Kozuka, Takahiro Inoue, Naoya Hasegawa, Tadayoshi Asaka
Frontiers in Human Neuroscience, 15, 740509, 740509, Frontiers Media SA, 28 Oct. 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal, Knowledge about the developmental process of dynamic balance control comprised of upper arms and upper legs coordination and trunk and pelvis twist coordination is important to advance effective balance assessment for abnormal development. However, the mechanisms of these coordination and stability control during gait in childhood are unknown.This study examined the development of dynamic postural stability, upper arm and upper leg coordination, and trunk and pelvic twist coordination during gait, and investigated the potential mechanisms integrating the central nervous system with inter-limb coordination and trunk and pelvic twist coordination to control extrapolated center of the body mass (XCOM). This study included 77 healthy children aged 3–10 years and 15 young adults. The child cohort was divided into four groups by age: 3–4, 5–6, 7–8, and 9–10 years. Participants walked barefoot at a self-selected walking speed along an 8 m walkway. A three-dimensional motion capture system was used for calculating the XCOM, the spatial margin of stability (MoS), and phase coupling movements of the upper arms, upper legs, trunk, and pelvic segments. MoS in the mediolateral axis was significantly higher in the young adults than in all children groups. Contralateral coordination (ipsilateral upper arm and contralateral upper leg combination) gradually changed to an in-phase pattern with increasing age until age 9 years. Significant correlations of XCOM_ML with contralateral coordination and with trunk and pelvic twist coordination (trunk/pelvis coordination) were found. Significant correlations between contralateral coordination and trunk/pelvis coordination were observed only in the 5–6 years and at 7–8 years groups.Dynamic postural stability during gait was not fully mature at age 10. XCOM control is associated with the development of contralateral coordination and trunk and pelvic twist coordination. The closer to in-phase pattern of contralateral upper limb coordination improved the XCOM fluctuations. Conversely, the out-of-phase pattern (about 90 degrees) of the trunk/pelvis coordination increased theXCOM fluctuation. Additionally, a different control strategy was used among children 3–8 years of age and individuals over 9 years of age, which suggests that 3–4-year-old children showed a disorderly coordination strategy between limb swing and torso movement, and in children 5–8 years of age, limb swing depended on trunk/pelvis coordination.

Chopstick operation training with the left non-dominant hand
Daisuke Sawamura, Satoshi Sakuraba, Kazuki Yoshida, Naoya Hasegawa, Yumi Suzuki, Susumu Yoshida, Toshihiro Honke, Shinya Sakai
Translational Neuroscience, 12, 1, 385, 395, Walter de Gruyter GmbH, 22 Oct. 2021, [International Magazine]
English, Scientific journal,


Training a non-dominant hand is important for rehabilitating people who are required to change handedness. However, improving the dexterity in using chopsticks with a non-dominant hand through training remains unclear. This study is aimed to measure whether chopstick training improves non-dominant hand chopstick operation skills and leads to acquisition of skill levels similar to those of the dominant hand.





This single-blinded randomized controlled trial enrolled 34 healthy young right-handed subjects who scored >70 points on the Edinburgh Handedness Questionnaire Inventory. They were randomly allocated to training or control groups. The training group participated in a 6-week chopstick training program with the non-dominant left hand, while the control group did not. Asymmetry of chopstick operation skill, perceived psychological stress, and oxygen-hemoglobin concentration as a brain activity measure in each hemisphere were measured before and after training.





Participants in the training group had significantly lower asymmetry than those in the control group during the post-training assessment (F[1,30] ≥ 5.54, p ≤ 0.03, partial η

²
≥ 0.156). Only perceived psychological stress had a significantly higher asymmetry during the post-training assessment (t[15] = 3.81, p < 0.01).





Six weeks of chopstick training improved non-dominant chopstick operation skills, and a performance level similar to that of the dominant hand was acquired.

Effects on forward stability limits by floating toes during standing
Ayane Yokoyama, Hiroki Mani, Naoya Hasegawa, Shenlei Tang, Yasuyuki Takamatsu, Tadayoshi Asaka
Health and Behavior Sciences, 20, 1, 13, 18, 日本健康行動科学会, Sep. 2021, [Peer-reviewed], [Domestic magazines]
Japanese, 13888646

Adaptation of the Compensatory Stepping Response Following Predictable and Unpredictable Perturbation Training.
Naoya Hasegawa, Shintaro Tanaka, Hiroki Mani, Takahiro Inoue, Yun Wang, Kazuhiko Watanabe, Tadayoshi Asaka
Frontiers in human neuroscience, 15, 674960, 674960, 15 Jun. 2021, [Peer-reviewed], [Lead author], ［Internationally co-authored］, [International Magazine]
English, Scientific journal, Background: Effective training of the backward step response could be beneficial to improve postural stability and prevent falls. Unpredicted perturbation-based balance training (PBT), widely known as compensatory-step training, may enhance the fear of falling and the patterns of postural muscle co-contraction. Contrastingly, PBT with predictable direction or both direction and timing would suppress the fear and the co-contraction patterns during training, but the efficacy of predictable PBT for unpredictable perturbations is still unknown. Objective: To compare the adaptation effects of compensatory-step training with and without predictable perturbations on backward stepping against unpredictable perturbations. Methods: Thirty-three healthy young adults were randomly assigned to one of the following step training groups: Unpredicted, Predicted, and Self-initiated. In training sessions, participants were perturbed to induce a compensatory step with (Predicted group) or without (Unpredicted group) knowledge of the perturbation's direction or while knowing both the direction and timing of the perturbation (Self-initiated group). In test sessions (pre- and post-training), participants were instructed to recover their postural stability in response to an unpredicted perturbation. The margin of stability (MOS), center of mass (COM) shift, and step characteristics were measured during a backward step in both test and training sessions. Results: All three groups showed a significant increase in the step length and velocity in the post-training sessions compared to those in the pre-training sessions. Moreover, in the Unpredicted and Predicted groups, but not in the Self-initiated group, the MOS at step contact was significantly increased following the training session. In addition, the Self-initiated group showed a significant increase in COM shift at 50 ms after slip onset during training compared to the Unpredicted and Predicted groups. Conclusion: Unpredicted and predicted PBT improve step characteristics during backward stepping against unpredictable perturbations. Moreover, the unpredictable PBT and PBT with direction-predictable perturbations enhance the feedback postural control reflected as the postural stability at step contact., 13888646

Specific inhibition of α5 subunit-containing GABAA receptors enhances locomotor activity and neuronal activity in the motor cortex.
Takahiro Inoue, Yasuyuki Takamatsu, Misato Okamura, Hiroki Mani, Naoya Hasegawa, Hiroshi Maejima
Biomedical research (Tokyo, Japan), 42, 3, 103, 108, 07 Jun. 2021, [Peer-reviewed], [Domestic magazines]
English, Scientific journal, Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter in the central nervous system (CNS). This study examined the effect of specific inhibition of α5 subunit-containing GABAA receptors (α5GABAAR) on the behavioral profile and neuronal activity of the CNS using a compound called L-655,708, which is a selective negative allosteric modulator of α5GABAAR. L-655,708 administration significantly increased locomotor activity without anxiety-related behavior. Furthermore, L-655,708 administration significantly increased c-Fos mRNA expression (a neuronal activity marker) in motor area of the cerebral cortex, whereas it hardly altered c-Fos mRNA expression in the sensory cortex, hippocampus, and spinal cord. This study revealed for the first time that alteration of neuronal activity with specific inhibition of α5GABAAR differs depending on each CNS region. α5GABAAR could be a potential target for modulating CNS excitability and behavioral activity.

Functional limits of stability and standing balance in people with Parkinson's disease with and without freezing of gait using wearable sensors.
Naoya Hasegawa, Kas C Maas, Vrutangkumar V Shah, Patricia Carlson-Kuhta, John G Nutt, Fay B Horak, Tadayoshi Asaka, Martina Mancini
Gait & posture, 87, 123, 129, 19 Apr. 2021, [Peer-reviewed], [Lead author], ［Internationally co-authored］, [International Magazine]
English, Scientific journal, BACKGROUND: People with from Parkinson's disease (PD) and freezing of gait (FoG) have more frequent falls compared to those who do not freeze but there is no consensus on which, specific objective measures of postural instability are worse in freezers (PD + FoG) than non-freezers (PD-FoG). RESEARCH QUESTION: Are functional limits of stability (fLoS) or postural sway during stance measured with wearable inertial sensors different between PD + FoG versus PD-FoG, as well as between PD versus healthy control subjects (HC)? METHODS: Sixty-four PD subjects with FoG (MDS-UPDRS Part III: 45.9 ± 12.5) and 80 PD subjects without FoG (MDS-UPDRS Part III: 36.2 ± 10.9) were tested Off medication and compared with 79 HC. Balance was quantified with inertial sensors worn on the lumbar spine while performing the following balance tasks: 1) fLoS as defined by the maximum displacement in the forward and backward directions and 2) postural sway area while standing with eyes open on a firm and foam surface. An ANOVA, controlling for disease duration, compared postural control between groups. RESULTS: PD + FoG had significantly smaller fLoS compared to PD-FoG (p =  0.004) and to healthy controls (p <  0.001). However, PD-FoG showed similar fLoS compared to healthy controls (p =  0.48). Both PD+FoG and PD-FoG showed larger postural sway on a foam surface compared to healthy controls (p =  0.001) but there was no significant difference in postural sway between PD+FoG and PD-FoG. SIGNIFICANCE: People with PD and FoG showed task-specific, postural impairments with smaller fLoS compared to non-freezers, even when controlling for disease duration. However, individuals with PD with or without FoG had similar difficulties standing quietly on an unreliable surface compared to healthy controls. Wearable inertial sensors can reveal worse fLoS in freezers than non-freezers that may contribute to FoG and help explain their more frequent falls., 31407822

Effects of simulated peripheral visual field loss on the static postural control in young healthy adults.
Kenji Taneda, Hiroki Mani, Norio Kato, Shunsuke Komizunai, Keita Ishikawa, Takashi Maruya, Naoya Hasegawa, Yasuyuki Takamatsu, Tadayoshi Asaka
Gait & posture, 86, 233, 239, 10 Mar. 2021, [Peer-reviewed], [International Magazine]
English, Scientific journal, BACKGROUND: Integration of visual, vestibular, and proprioceptive sensations contributes to postural control. People with peripheral visual field loss have serious postural instability. However, the directional specificity of postural stability and sensory reweighting caused by gradual peripheral visual field loss remain unclear. RESEARCH QUESTION: What are the effects of peripheral visual field loss on static postural control? METHODS: Fifteen healthy young adults participated in this study. The participants were asked to stand quietly on a foam surface. Three conditions of virtual visual field loss (90°, 45°, and 15°) were provided by a head-mounted display, and ground reaction forces were collected using a force plate to calculate the displacements of the center of pressure (COP). RESULTS: The root mean square (RMS), mean velocity, and 95% ellipse area of COP displacements in the horizontal plane increased, and RMS in the anteroposterior (AP) direction was unchanged under the smallest visual field condition compared to the largest one. The power spectrum density of COP displacements in the low-frequency band was decreased and that in the medium-frequency band was increased in the AP direction. SIGNIFICANCE: During quiet standing of young healthy adults with peripheral visual field loss, increased peripheral visual field loss resulted in lower postural stability. Postural stability in the AP direction was maintained contrary to the functional sensitivity hypothesis. Peripheral visual field loss reduced the weighting of the visual input and increased that of the vestibular input in the AP direction to maintain equilibrium., 13888646

Dual-Task Costs of Quantitative Gait Parameters While Walking and Turning in People with Parkinson's Disease: Beyond Gait Speed.
Rodrigo Vitorio, Naoya Hasegawa, Patricia Carlson-Kuhta, John G Nutt, Fay B Horak, Martina Mancini, Vrutangkumar V Shah
Journal of Parkinson's disease, 29 Dec. 2020, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
English, Scientific journal, BACKGROUND: There is a lack of recommendations for selecting the most appropriate gait measures of Parkinson's disease (PD)-specific dual-task costs to use in clinical practice and research. OBJECTIVE: We aimed to identify measures of dual-task costs of gait and turning that best discriminate performance in people with PD from healthy individuals. We also investigated the relationship between the most discriminative measures of dual-task costs of gait and turning with disease severity and disease duration. METHODS: People with mild-to-moderate PD (n = 144) and age-matched healthy individuals (n = 79) wore 8 inertial sensors while walking under single and dual-task (reciting every other letter of the alphabet) conditions. Outcome measures included 26 objective measures within four gait domains (upper/lower body, turning and variability). The area under the curve (AUC) from the receiver-operator characteristic plot was calculated to compare discriminative ability of dual-task costs on gait across outcome measures. RESULTS: PD-specific, dual-task interference was identified for arm range of motion, foot strike angle, turn velocity and turn duration. Arm range of motion (AUC = 0.73) and foot strike angle (AUC = 0.68) had the largest AUCs across dual-task costs measures and they were associated with disease severity and/or disease duration. In contrast, the most commonly used dual-task gait measure, gait speed, showed an AUC of only 0.54. CONCLUSION: Findings suggest that people with PD rely more than healthy individuals on executive-attentional resources to control arm swing, foot strike, and turning, but not gait speed. The dual-task costs of arm range of motion best discriminated people with PD from healthy individuals.

Differential effects of visual versus auditory biofeedback training for voluntary postural sway.
Naoya Hasegawa, Kenta Takeda, Martina Mancini, Laurie A King, Fay B Horak, Tadayoshi Asaka
PloS one, 15, 12, e0244583, 28 Dec. 2020, [Peer-reviewed], [Lead author], ［Internationally co-authored］, [International Magazine]
English, Scientific journal, Augmented sensory biofeedback training is often used to improve postural control. Our previous study showed that continuous auditory biofeedback was more effective than continuous visual biofeedback to improve postural sway while standing. However, it has also been reported that both discrete visual and auditory biofeedback training, presented intermittently, improves bimanual task performance more than continuous visual biofeedback training. Therefore, this study aimed to investigate the relative effectiveness of discrete visual biofeedback versus discrete auditory biofeedback to improve postural control. Twenty-two healthy young adults were randomly assigned to either a visual or auditory biofeedback group. Participants were asked to shift their center of pressure (COP) by voluntary postural sway forward and backward in line with a hidden target, which moved in a sinusoidal manner and was displayed intermittently. Participants were asked to decrease the diameter of a visual circle (visual biofeedback) or the volume of a sound (auditory biofeedback) based on the distance between the COP and the target in the training session. The feedback and the target were given only when the target reached the inflection points of the sine curves. In addition, the perceptual magnitudes of visual and auditory biofeedback were equalized using Stevens' power law. Results showed that the mean and standard deviation of the distance between COP and the target were reduced int the test session, removing the augmented sensory biofeedback, in both biofeedback training groups. However, the temporal domain of the performance improved in the test session in the auditory biofeedback training group, but not in the visual biofeedback training group. In conclusion, discrete auditory biofeedback training was more effective for the motor learning of voluntarily postural swaying compared to discrete visual biofeedback training, especially in the temporal domain., 13888646

Effects of the agility boot camp with cognitive challenge (ABC-C) exercise program for Parkinson's disease.
Se Hee Jung, Naoya Hasegawa, Martina Mancini, Laurie A King, Patricia Carlson-Kuhta, Katrijn Smulders, Daniel S Peterson, Nancy Barlow, Graham Harker, Rosie Morris, Jodi Lapidus, John G Nutt, Fay B Horak
NPJ Parkinson's disease, 6, 1, 31, 31, 02 Nov. 2020, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
English, Scientific journal, Few exercise interventions practice both gait and balance tasks with cognitive tasks to improve functional mobility in people with PD. We aimed to investigate whether the Agility Boot Camp with Cognitive Challenge (ABC-C), that simultaneously targets both mobility and cognitive function, improves dynamic balance and dual-task gait in individuals with Parkinson's disease (PD). We used a cross-over, single-blind, randomized controlled trial to determine efficacy of the exercise intervention. Eighty-six people with idiopathic PD were randomized into either an exercise (ABC-C)-first or an active, placebo, education-first intervention and then crossed over to the other intervention. Both interventions were carried out in small groups led by a certified exercise trainer (90-min sessions, 3 times a week, for 6 weeks). Outcome measures were assessed Off levodopa at baseline and after the first and second interventions. A linear mixed-effects model tested the treatment effects on the Mini-BESTest for balance, dual-task cost on gait speed, SCOPA-COG, the UPDRS Parts II and III and the PDQ-39. Although no significant treatment effects were observed for the Mini-BESTest, SCOPA-COG or MDS-UPDRS Part III, the ABC-C intervention significantly improved the following outcomes: anticipatory postural adjustment sub-score of the Mini-BESTest (p = 0.004), dual-task cost on gait speed (p = 0.001), MDS-UPDRS Part II score (p = 0.01), PIGD sub-score of MDS-UPDRS Part III (p = 0.02), and the activities of daily living domain of the PDQ-39 (p = 0.003). Participants with more severe motor impairment or more severe cognitive dysfunction improved their total Mini-BESTest scores after exercise. The ABC-C exercise intervention can improve specific balance deficits, cognitive-gait interference, and perceived functional independence and quality of life, especially in participants with more severe PD, but a longer period of intervention may be required to improve global cognitive and motor function.

Responsiveness of Objective vs. Clinical Balance Domain Outcomes for Exercise Intervention in Parkinson's Disease.
Naoya Hasegawa, Vrutangkumar V Shah, Graham Harker, Patricia Carlson-Kuhta, John G Nutt, Jodi A Lapidus, Se Hee Jung, Nancy Barlow, Laurie A King, Fay B Horak, Martina Mancini
Frontiers in neurology, 11, 940, 940, 25 Sep. 2020, [Peer-reviewed], [Lead author], ［Internationally co-authored］, [International Magazine]
English, Scientific journal, Background: Balance deficits in people with Parkinson's disease (PD) are often not helped by pharmacological or surgical treatment. Although balance exercise intervention has been shown to improve clinical measures of balance, the efficacy of exercise on different, objective balance domains is still unknown. Objective: To compare the sensitivity to change in objective and clinical measures of several different domains of balance and gait following an Agility Boot Camp with Cognitive Challenges (ABC-C) intervention. Methods: In this cross-over, randomized design, 86 individuals with PD participated in 6-week (3×/week) ABC-C exercise classes and 6-week education classes, consisting of 3-6 individuals. Blinded examiners tested people in their practical off state. Objective outcome measures from wearable sensors quantified four domains of balance: sway in standing balance, anticipatory postural adjustments (APAs) during step initiation, postural responses to the push-and-release test, and a 2-min natural speed walk with and without a cognitive task. Clinical outcome measures included the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part III, the Mini Balance Evaluation Systems Test (Mini-BESTest), the Activities of Balance Confidence (ABC), and the Parkinson's Disease Questionnaire (PDQ-39). The standardized response means (SRM) of the differences between before and after each intervention compared responsiveness of outcomes to intervention. A linear mixed model compared effects of exercise with the active control-education intervention. Results: The most responsive outcome measures to exercise intervention with an SRM > 0.5 were objective measures of gait and APAs, specifically arm range of motion, gait speed during a dual-task walk, trunk coronal range of motion, foot strike angle, and first-step length at step initiation. The most responsive clinical outcome measure was the patient-reported PDQ-39 activities daily living subscore, but all clinical measures had SRMs <0.5. Conclusions: The objective measures were more sensitive to change after exercise intervention compared to the clinical measures. Spatiotemporal parameters of gait, including gait speed with a dual task, and APAs were the most sensitive objective measures, and perceived functional independence was the most sensitive clinical measure to change after the ABC-C exercise intervention. Future exercise intervention to improve gait and balance in PD should include objective outcome measures., 31407822

Short-term effects of postural control by standing on a tilting board in patients with Parkinson's disease.
Naoya Hasegawa, Keita Ishikawa, Yuki Sato, Yasuhide Nakayama, Tadayoshi Asaka
Physiotherapy theory and practice, 37, 12, 1, 7, 26 Nov. 2019, [Peer-reviewed], [Lead author], [International Magazine]
English, Scientific journal, 13888646

How to Select Balance Measures Sensitive to Parkinson's Disease from Body-Worn Inertial Sensors-Separating the Trees from the Forest.
Naoya Hasegawa, Vrutangkumar V Shah, Patricia Carlson-Kuhta, John G Nutt, Fay B Horak, Martina Mancini
Sensors (Basel, Switzerland), 19, 15, 28 Jul. 2019, [Peer-reviewed], [Invited], [Lead author], ［Internationally co-authored］, [International Magazine]
English, Scientific journal, This study aimed to determine the most sensitive objective measures of balance dysfunction that differ between people with Parkinson's Disease (PD) and healthy controls. One-hundred and forty-four people with PD and 79 age-matched healthy controls wore eight inertial sensors while performing tasks to measure five domains of balance: standing posture (Sway), anticipatory postural adjustments (APAs), automatic postural responses (APRs), dynamic posture (Gait) and limits of stability (LOS). To reduce the initial 93 measures, we selected uncorrelated measures that were most sensitive to PD. After applying a threshold on the Standardized Mean Difference between PD and healthy controls, 44 measures remained; and after reducing highly correlated measures, 24 measures remained. The four most sensitive measures were from APAs and Gait domains. The random forest with 10-fold cross-validation on the remaining measures (n = 24) showed an accuracy to separate PD from healthy controls of 82.4%-identical to result for all measures. Measures from the most sensitive domains, APAs and Gait, were significantly correlated with the severity of disease and with patient-related outcomes. This method greatly reduced the objective measures of balance to the most sensitive for PD, while still capturing four of the five domains of balance.

Learning effects of dynamic postural control by auditory biofeedback versus visual biofeedback training.
Naoya Hasegawa, Kenta Takeda, Moe Sakuma, Hiroki Mani, Hiroshi Maejima, Tadayoshi Asaka
Gait & posture, 58, 188, 193, 02 Aug. 2017, [Peer-reviewed], [Lead author], [International Magazine]
English, Scientific journal

Adaptation effects in static postural control by providing simultaneous visual feedback of center of pressure and center of gravity.
Kenta Takeda, Hiroki Mani, Naoya Hasegawa, Yuki Sato, Shintaro Tanaka, Hiroshi Maejima, Tadayoshi Asaka
Journal of physiological anthropology, 36, 1, 31, 31, 19 Jul. 2017, [Peer-reviewed], [International Magazine]
English, Scientific journal

Characteristic Relationship between the Centre of Pressure and the Centre of Mass During Quiet Standing in Female Ballet Dancers
Ibuki A, Mani H, Takeda K, Hasegawa N, Yamamoto K, Naejima H, Asaka T
International Physical Medicine & Rehabilitation Journal, 1, 2, 34, 36, MedCrave Group, LLC, 18 May 2017, [Peer-reviewed], [International Magazine]
English, Scientific journal

クロスステップ反復練習による片脚立位動作時の姿勢安定性への効果
萬井 太規, 長谷川 直哉, 武田 賢太, 伊吹 愛梨, 佐久間 萌, 石川 啓太, 前島 洋, 浅賀 忠義
理学療法科学, 31, 4, 601, 607, (一社)理学療法科学学会, Aug. 2016, [Peer-reviewed], [Domestic magazines]
Japanese

Adaptation of postural control while standing on a narrow unfixed base of support.
Hiroki Mani, Shih-Fen Hsiao, Tomoya Konishi, Tatsuya Izumi, Akiyo Tsuda, Naoya Hasegawa, Kenta Takeda, Noriyo Colley, Tadayoshi Asaka
International journal of rehabilitation research. Internationale Zeitschrift fur Rehabilitationsforschung. Revue internationale de recherches de readaptation, 39, 1, 92, 5, Mar. 2016, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
English, Scientific journal

視覚フィードバックと聴覚フィードバックによる動的バランスの学習効果の違い
長谷川 直哉, 萬井 太規, 武田 賢太, 佐久間 萌, 笠原 敏史, 浅賀 忠義
理学療法学, 42, 6, 474, 479, (公社)日本理学療法士協会, Oct. 2015, [Peer-reviewed], [Lead author], [Domestic magazines]
Japanese

Age-related changes in distance from center of mass to center of pressure during one-leg standing.
Hiroki Mani, Shih-Fen Hsiao, Kenta Takeda, Naoya Hasegawa, Mitsuhisa Tozuka, Akiyo Tsuda, Tetsuro Ohashi, Tsukasa Suwahara, Kumiko Ito, Tadayoshi Asaka
Journal of motor behavior, 47, 4, 282, 90, 2015, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
English, Scientific journal

視覚障害を併存する対象者の理学療法を考える 視覚障害が姿勢制御や運動学習に与える影響
長谷川直哉, 理学療法ジャーナル, 58, 7, 779, 784, Jul. 2024, [Invited]
(株)医学書院, Japanese

知覚・認知と運動制御 19 感覚フィードバックと姿勢制御の運動学習
長谷川直哉, 理学療法(東京), 40, 12, 1123, 1130, Dec. 2023, [Invited]
(株)メディカルプレス, Japanese

【システムとしての姿勢制御-メカニズムの解明から臨床応用まで】聴覚フィードバックを用いた姿勢制御アプローチ
長谷川 直哉, 理学療法ジャーナル, 57, 3, 306, 312, Mar. 2023, [Invited], [Lead author, Corresponding author], [Domestic magazines]
(株)医学書院, Japanese, 13888646

視覚誘導性自己運動錯覚と立位姿勢制御に対してオプティックフローの速度と提示範囲が及ぼす影響
愛甲拓海, 黒木尭稀, 加藤士雄, 長谷川直哉, 萬井太規, 基礎理学療法学(Web), 26, Supplement, 18, 18, 2023
(一社)日本基礎理学療法学会, Japanese

床面の安定性と認知課題実施が静的姿勢バランスに与える影響
川田亜弥, 榊悠介, 赤木啓真, 石村光, 井上愛菜, 西山仁, 唐申雷, 萬井大槻, 浅賀忠義, 長谷川直哉, 基礎理学療法学(Web), 26, Supplement, 66, 66, 2023
(一社)日本基礎理学療法学会, Japanese

感覚様式の異なる認知負荷が静止立位時の姿勢制御に与える影響
榊悠介, 石村光, 赤木啓真, 川田亜弥, 井上愛菜, 西山仁, 唐申雷, 萬井太規, 浅賀忠義, 長谷川直哉, 基礎理学療法学(Web), 26, Supplement, 63, 63, 2023
(一社)日本基礎理学療法学会, Japanese

パーキンソン病患者における傾斜台上立位保持練習が姿勢バランスに与える即時効果について
赤木啓真, 榊悠介, 成田雅, 川田亜弥, 石村光, 井上愛菜, 西山仁, 萬井太規, 浅賀忠義, 長谷川直哉, 基礎理学療法学(Web), 26, Supplement, 110, 110, 2023
(一社)日本基礎理学療法学会, Japanese

パーキンソン病患者の反復転倒に恐怖感情が与える影響
冨居泰臣, 大槻美佳, 長谷川直哉, 慢性期リハビリテーション学会(Web), 9th, 2022

認知負荷による有効視野の狭窄が姿勢安定性に与える影響について
大久保結羽, 長谷川直哉, 榊悠介, 赤木啓真, 川田亜弥, TANG Shenlei, 萬井大槻, 浅賀忠義, 基礎理学療法学(Web), 25, Supplement, 87, 87, 2022
(一社)日本基礎理学療法学会, Japanese

安静時立位バランスにおける足部への温熱効果に関する研究
丸谷暁子, 丸谷暁子, 長谷川直哉, 唐申雷, 丸谷孝史, 丸谷孝史, 浅賀忠義, 基礎理学療法学(Web), 25, Supplement, 2022

視野の下部領域のオプティカルフローは非視覚系の立位姿勢制御戦略に変容させる
萬井太規, 加藤士雄, 浦野雄飛, 黒木尭稀, 愛甲拓海, 長谷川直哉, 浅賀忠義, 基礎理学療法学(Web), 25, Supplement, 2022

異なる難易度の認知負荷が予測的姿勢制御の適応結果に与える影響について
榊悠介, 長谷川直哉, 大久保結羽, 赤木啓真, 川田亜弥, 唐申雷, 萬井太規, 浅賀忠義, 基礎理学療法学(Web), 25, Supplement, 81, 81, 2022
(一社)日本基礎理学療法学会, Japanese

運動学習(11)各論(2)パーキンソン病患者に対する運動学習理論を応用した理学療法の展開
長谷川 直哉, 理学療法, 38, 9, 843, 850, Sep. 2021, [Invited], [Lead author, Corresponding author], [Domestic magazines]
メディカルプレス, Japanese, 31407822

断続的なフィードバック練習に用いる感覚の違いが姿勢バランス課題の運動学習に与える影響について
長谷川 直哉, Martina Mancini, Laurie King, Fay Horak, 浅賀 忠義, 理学療法学, 47, Suppl.1, 187, 187, Mar. 2021, [Peer-reviewed], [Lead author], ［Internationally co-authored］, [Domestic magazines]
(公社)日本理学療法士協会, Japanese, Summary national conference

Effects on forward stability limits by floating toes during standing
横山文音, 萬井太規, 長谷川直哉, TANG Shenlei, 高松奉行, 浅賀忠義, Health and Behavior Sciences, 20, 1, 2021

反復転倒するパーキンソン病患者の恐怖感情は低下しているか?-予備的研究-
冨居泰臣, 冨居泰臣, 大槻美佳, 長谷川直哉, 日本高次脳機能障害学会学術総会プログラム・講演抄録, 45th (CD-ROM), 2021

反復転倒するパーキンソン病患者のバランス能力に対する認識-課題による認識誤差の違い:予備的研究-
冨居泰臣, 冨居泰臣, 大槻美佳, 長谷川直哉, 日本高次脳機能障害学会学術総会プログラム・講演抄録, 45th (CD-ROM), 2021

在宅パーキンソン病患者の姿勢制御能力の評価に有効な指標の検討-加速度計から得られた客観的な指標を用いて-
長谷川直哉, 長谷川直哉, 横山文音, TANG Shenlei, HORAK Fay, 浅賀忠義, MANCINI Martina, 日本理学療法学術大会(Web), 55th, 2021

在宅パーキンソン病患者の生活の質に影響を与える要因の検討-社会的資源の活用に着目して-
遠藤正裕, 長谷川直哉, 長谷川直哉, 田中真悟, 日本理学療法学術大会(Web), 55th, 2021

在宅パーキンソン病患者に対する認知課題を伴うMultiple trainingが姿勢制御能力に与える効果
長谷川直哉, 長谷川直哉, KING Laurie, HORAK Fay, 浅賀忠義, MANCINI Martina, 日本理学療法学術大会(Web), 55th, 2021

段差高の変化に伴う昇段時の予測的姿勢調節の制御特性
萬井太規, 愛甲拓海, 浦野雄飛, 黒木尭稀, 長谷川直哉, 浅賀忠義, 基礎理学療法学(Web), 24, Supplement, 2021

Role of ventricle volume in the association between cognitive status and mobility metrics in Parkinson’s disorders: A mediation analysis　　　　　　　　　　　　　　　
Ragothamani A, Hasegawa N, Neuroscience 2019, Oct. 2019, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
English, Summary international conference

Turning features in people with Parkinson’s disease, spinocerebellar ataxia, and healthy control subjects　　　　　　　　　　　　　　　
Shah VV, Hasegawa N, Neuroscience 2019, Oct. 2019, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
English, Summary international conference

Multiple domains of postural control in Parkinson’s disease; feature selection of mobility measures　　　　　　　　　　　　　　　
King LA, Hasegawa N, Neuroscience 2019, Oct. 2019, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
English, Summary international conference

Effects of an agility exercise program with cognitive challenges on objective measures of gait and balance in people with Parkinson’s disease　　　　　　　　　　　　　　　
Carlson-Kuhta P, Hasegawa N, Neuroscience 2019, Oct. 2019, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
English, Summary international conference

Effects of Cognitively Challenging Agility Exercise Program on Clinical and Objective Measures in People with Parkinson’s Disease　　　　　　　　　　　　　　　
Carlson-Kuhta P, Hasegawa N, 2019 International Parkinson and Movement Disorder Society Congress, Sep. 2019, [Peer-reviewed], ［Internationally co-authored］, [International Magazine]
English, Summary international conference

Effects of a 6-week cognitively challenging agility exercise program in people with Parkinson's disease　　　　　　　　　　　　　　　
Horak FB, Hasegawa N, 2019 ISPGR World Congress, Jun. 2019
English

視覚および聴覚のフィードバック練習による動的バランスの学習効果に関する研究　　　　　　　　　　　　　　　
長谷川 直哉, 北海道大学 大学院保健科学院, Mar. 2018, [Peer-reviewed]

パーキンソン病患者に対する傾斜台立位の効果について
船水 風花, 佐藤 祐樹, 長谷川 直哉, 浅賀 忠義, Health and Behavior Sciences, 16, 1, 35, 35, Sep. 2017
日本健康行動科学会, Japanese

立位姿勢反応と安定性限界が改善したパーキンソン病患者の一症例 足圧中心随伴型床面移動刺激装置を用いた練習効果
武田 賢太, 花木 里穂, 長谷川 直哉, 萬井 太規, 菅田 葉月, 浅賀 忠義, Health and Behavior Sciences, 16, 1, 36, 36, Sep. 2017
日本健康行動科学会, Japanese

周辺視野狭窄が姿勢安定性に及ぼす影響について
種田 健二, 田中 晨太郎, 武田 賢太, 長谷川 直哉, 小玉 祐也, 萬井 太規, 浅賀 忠義, Health and Behavior Sciences, 16, 1, 38, 38, Sep. 2017
日本健康行動科学会, Japanese

Influences of visual field loss for postural stability during quiet standing in healthy young adults　　　　　　　　　　　　　　　
Taneda K, Hasegawa N, The Third FHS International Conference, Jul. 2017
English

バランスボード上の姿勢戦略の順応効果
萬井 太規, 長谷川 直哉, 武田 賢太, 佐藤 佑樹, 田中 晨太郎, 呉 瑕, 前島 洋, 浅賀 忠義, 理学療法学, 44, Suppl.2, P, 1, Apr. 2017
(公社)日本理学療法士協会, Japanese

傾斜台上立位保持がパーキンソン病患者の安定性限界と歩行に与える即時効果
長谷川 直哉, 佐藤 祐樹, 武田 賢太, 大橋 哲朗, 田中 晨太郎, 丸谷 孝史, 加藤 新司, 中山 恭秀, 萬井 太規, 浅賀 忠義, 理学療法学, 44, Suppl.2, P, 1, Apr. 2017
(公社)日本理学療法士協会, Japanese

反復後方ステップ練習による非予測的外乱時の即時効果
田中 晨太郎, 長谷川 直哉, 武田 賢太, 大橋 哲朗, 佐藤 祐樹, 呉 瑕, 丸谷 孝史, 金 雪梅, 萬井 太規, 前島 洋, 浅賀 忠義, 理学療法学, 44, Suppl.2, P, 2, Apr. 2017
(公社)日本理学療法士協会, Japanese

Effects of visual feedback training using center of gravity along with center of pressure for static postural balance　　　　　　　　　　　　　　　
Mani H, Hasegawa N, Neuroscience 2016, Nov. 2016
English

Cortical processes to predict timing gait initiation through visual information　　　　　　　　　　　　　　　
Takeda K, Hasegawa N, Neuroscience 2016, Nov. 2016
English

クラシックバレエ経験者と非経験者における立位姿勢制御の比較
伊吹 愛梨, 長谷川 直哉, 武田 賢太, 石川 啓太, 佐久間 萌, 佐藤 祐樹, 田中 晨太郎, 萬井 太規, 前島 洋, 浦賀 忠義, 理学療法学, 43, Suppl.2, P, 1, Oct. 2016
(公社)日本理学療法士協会, Japanese

パーキンソン病患者に対するトレッドミル後進歩行の効果について 3軸加速度センサー内臓携帯歩行計による検討　　　　　　　　　　　　　　　
野村 恭平, 長谷川 直哉, 成田 雅, 理学療法学, 43, Suppl.2, O, 2, Oct. 2016
(公社)日本理学療法士協会, Japanese

バランスボード上における姿勢制御の順応効果について
萬井 太規, 長谷川 直哉, 武田 賢太, 佐久間 萌, 伊吹 愛梨, 石川 啓太, Hsiao Shi-Fen, 浅賀 忠義, 理学療法学, 43, Suppl.2, O, 1, Oct. 2016
(公社)日本理学療法士協会, Japanese

口頭指示の違いが姿勢安定性と姿勢戦略に与える影響
佐久間 萌, 長谷川 直哉, 武田 賢太, 伊吹 愛梨, 石川 啓太, 田中 晨太郎, 佐藤 祐樹, 呉 瑕, 萬井 太規, 前島 洋, 浅賀 忠義, 理学療法学, 43, Suppl.2, P, 3, Oct. 2016
(公社)日本理学療法士協会, Japanese

予測的な反復後方ステップ練習による非予測的外乱時の即時効果　　　　　　　　　　　　　　　
田中 晨太郎, 長谷川 直哉, 武田 賢太, 呉 瑕, 浅賀 忠義, Health and Behavior Sciences, 15, 1, 32, 32, Aug. 2016
日本健康行動科学会, Japanese

周期的な動作課題における視覚と聴覚フィードバック練習の学習効果の違い　　　　　　　　　　　　　　　
長谷川 直哉, 武田 賢太, 田中 辰太郎, 呉 瑕, 萬井 太規, 浅賀 忠義, Health and Behavior Sciences, 15, 1, 40, 40, Aug. 2016
日本健康行動科学会, Japanese

足圧中心と体重心の同時視覚フィードバック練習による静的立位バランスの効果
呉 瑕, 武田 健太, 長谷川 直哉, 田中 晨太郎, 浅賀 忠義, Health and Behavior Sciences, 15, 1, 41, 41, Aug. 2016
日本健康行動科学会, Japanese

視覚情報を用いたタイミング予測下における歩行開始時の皮質処理　　　　　　　　　　　　　　　
武田 賢太, 長谷川 直哉, 田中 辰太郎, 呉 瑕, 浅賀 忠義, Health and Behavior Sciences, 15, 1, 43, 43, Aug. 2016
日本健康行動科学会, Japanese

バランスボード上における姿勢制御の順応効果について
萬井 太規, 長谷川 直哉, 武田 賢太, 佐久間 萌, 伊吹 愛梨, 石川 啓太, Hsiao Shi-Fen, 浅賀 忠義, 日本基礎理学療法学雑誌, 20, 1, 67, 67, Aug. 2016
(一社)日本基礎理学療法学会, Japanese

クラシックバレエ経験者と非経験者における立位姿勢制御の比較
伊吹 愛梨, 長谷川 直哉, 武田 賢太, 石川 啓太, 佐久間 萌, 佐藤 祐樹, 田中 晨太郎, 萬井 太規, 前島 洋, 浅賀 忠義, 日本基礎理学療法学雑誌, 20, 1, 241, 241, Aug. 2016, [Domestic magazines]
(一社)日本基礎理学療法学会, Japanese, Summary national conference

口頭指示の違いが姿勢安定性と姿勢戦略に与える影響
佐久間 萌, 長谷川 直哉, 武田 賢太, 伊吹 愛梨, 石川 啓太, 田中 晨太郎, 佐藤 祐樹, 呉 瑕, 萬井 太規, 前島 洋, 浅賀 忠義, 日本基礎理学療法学雑誌, 20, 1, 307, 307, Aug. 2016, [Domestic magazines]
(一社)日本基礎理学療法学会, Japanese, Summary national conference

パーキンソン病患者に対するトレッドミル後進歩行の効果について
野村 恭平, 長谷川 直哉, 成田 雅, 理学療法学Supplement, 2015, 924, 924, 2016
【はじめに，目的】パーキンソン病は，安静時振戦，筋固縮，寡動，姿勢反射障害を特徴とする慢性進行性の神経変性疾患である。パーキンソン病患者は，すくみ足による歩行障害や姿勢反射障害による転倒等により，身体活動量の低下や社会参加の減少，QOL低下をもたらす。そのため，パーキンソン病患者の歩行障害に対して，体重支持下でのトレッドミル歩行や聴覚，視覚，体性感覚刺激での歩行練習などが行われており，いずれも歩幅や歩行速度の改善を認めている。トレッドミル後進歩行についても先行研究により，歩幅や歩行速度の改善に対する有用性を示す報告がなされているが，各パラメーターに対する詳細な報告は演者たちが知る限りない。本研究は，携帯型歩行解析装置を用いて，トレッドミル後進歩行前後での歩行を行い，歩行の各パラメーターの比較，検討を行った。【方法】対象は，自立歩行が可能であり，整形外科的疾患や重篤な認知機能障害を有さないパーキンソン病患者8名（男性3名，女性5名，平均年齢69.5±6.7歳，身長156.4±8.1cm，体重59.2±9.4kg，Hoehn ＆ Yahr分類にてI度：3名，II度：5名，Unified Parkinson's Disease Rating Scale運動項目：21.0±9.3）だった。先行研究を参考に傾斜を3％設け，快適速度（0.6～1.6km/h）でのトレッドミル後進歩行を5分間実施した。トレッドミル後進歩行前後で携帯型歩行解析装置を装着し，10m歩行にて，歩行速度，歩幅，上下方向および左右方向の平均振幅と標準偏差，力強さ（G），パーキンソン症状が強い一側を悪側，弱い一側を良側として立脚期と遊脚期および両脚支持期の平均秒数と変動係数（CV）を算出した。統計解析は，介入前（pre）と介入後（post）の測定結果を比較するために，対応のあるt検定を実施し，有意水準は5％未満とした。【結果】トレッドミル後進歩行前後で，良側支持時間（pre：0.43±0.04，post：0.44±0.03），上下振幅の標準偏差（pre：0.2±0.1cm，post：0.3±0.1cm）で介入前後での有意な増加がみられ，その他のパラメーターに有意差は認めなかった。【結論】本研究は，パーキンソン病患者に対するトレッドミル後進歩行後の効果について，携帯型歩行解析装置を用いて検証した。先行研究によると，健常者と高齢者の通常歩行の比較では健常者の上下振幅の標準偏差が高いことが報告されている。本研究の結果では介入後に上下振幅の標準偏差が増加しており，これはより正常な歩行に近づいた結果であると考える。また，良側支持時間の増加は被験者にとってより困難な条件での練習により良側への依存度が高まった結果と考える。本研究の結果より，トレッドミル後進歩行練習はパーキンソン病患者の歩行をより正常に近づける可能性があることが示唆される。今後は症例数を重ねてより詳細な検証をしていく必要がある。, 公益社団法人 日本理学療法士協会, Japanese

口頭指示の違いが姿勢バランスに与える影響 姿勢安定性と周波数特性に着目して
佐久間 萌, 萬井 太規, 長谷川 直哉, 武田 賢太, 伊吹 愛梨, 石川 啓太, 田中 晨太郎, 佐藤 祐樹, 呉 瑕, 前島 洋, 浅賀 忠義, 日本基礎理学療法学雑誌, 19, 1, 64, 64, Jan. 2016
(一社)日本基礎理学療法学会, Japanese

ターゲットの消失タイミングが歩行開始におけるタイミング予測に与える影響
武田 賢太, 長谷川 直哉, 伊吹 愛梨, 萬井 太規, 浅賀 忠義, Health and Behavior Sciences, 14, 1, 44, 44, Sep. 2015
日本健康行動科学会, Japanese

優れた静的バランス能力のメカニズム解明に関する研究
伊吹 愛梨, 萬井 太規, 長谷川 直哉, 武田 賢太, 浅賀 忠義, Health and Behavior Sciences, 14, 1, 52, 52, Sep. 2015
日本健康行動科学会, Japanese

クロスステップ練習が片脚立位動作時の姿勢安定性を向上させるか?
萬井 太規, 武田 賢太, 伊吹 愛梨, 長谷川 直哉, 浅賀 忠義, Health and Behavior Sciences, 14, 1, 52, 52, Sep. 2015
日本健康行動科学会, Japanese

Effects of timing of vanishing target on anticipatory timing during gait initiation　　　　　　　　　　　　　　　
Takeda K, Hasegawa N, International Symposium on Modern Health Sciences, Feb. 2015
English

視覚消失タイミングが歩行開始のタイミング予測に与える影響
武田 賢太, 萬井 太規, 諏訪原 司, 長谷川 直哉, 戸塚 満久, 津田 章代, 大橋 哲朗, 趙 静, 石川 啓太, 伊吹 愛梨, 佐久間 萌, 前島 洋, 浅賀 忠義, 日本基礎理学療法学雑誌, 18, 1, 65, 65, Nov. 2014
(一社)日本基礎理学療法学会, Japanese

口頭指示の違いが前方水平外乱における後方ステップに与える影響
諏訪原 司, 武田 賢太, 大橋 哲朗, 萬井 太規, 長谷川 直哉, 戸塚 満久, 津田 章代, 趙 静, 石川 啓太, 伊吹 愛梨, 佐久間 萌, 前島 洋, 浅賀 忠義, 日本基礎理学療法学雑誌, 18, 1, 66, 66, Nov. 2014
(一社)日本基礎理学療法学会, Japanese

着座動作の足関節可動域制限による姿勢と座面圧への影響について
大橋 哲朗, 萬井 太規, 諏訪原 司, 佐久間 萌, 長谷川 直哉, 戸塚 満久, 津田 章代, 武田 賢太, 伊吹 愛梨, 石川 啓太, 趙 静, 前島 洋, 浅賀 忠義, 日本基礎理学療法学雑誌, 18, 1, 66, 66, Nov. 2014
(一社)日本基礎理学療法学会, Japanese

The relationship between center of mass and center of pressure in the limits of stability　　　　　　　　　　　　　　　
Totsuka M, Hasegawa N, The 1st Asia - Pacific Conference on Coaching Science, Jul. 2014
English

Difference of the relative distances from center of pressure to center of mass between the young and elderly people during one-leg standing　　　　　　　　　　　　　　　
Mani H, Hasegawa N, The 1st Asia - Pacific Conference on Coaching Science, Jul. 2014
English

加齢に伴う片脚立位動作の不安定性要因について 体重心と足圧中心との位置関係に着目して
萬井 太規, 長谷川 直哉, 戸塚 満久, 津田 章代, 武田 賢太, 大橋 哲朗, 伊藤 久美子, 諏訪原 司, 趙 静, Hsiao Shi-Fen, 浅賀 忠義, 理学療法学, 41, 大会特別号2, 1146, 1146, May 2014
(公社)日本理学療法士協会, Japanese

感覚フィードバックの違いが動的バランスの学習効果に与える影響
長谷川 直哉, 萬井 太規, 戸塚 満久, 津田 章代, 伊藤 久美子, 大橋 哲朗, 諏訪原 司, 武田 賢太, 趙 静, Hsiao Shih-Fen, 笠原 敏史, 浅賀 忠義, 理学療法学, 41, 大会特別号2, 0296, 0296, May 2014, [Peer-reviewed]
(公社)日本理学療法士協会, Japanese

感覚フィードバックの違いが動的バランスの運動学習に与える影響について
長谷川 直哉, 萬井 太規, Hsiao Shih-Fen, 戸塚 満久, 津田 章代, 伊藤 久美子, 大橋 哲朗, 諏訪原 司, 武田 賢太, 趙 静, 浅賀 忠義, Health and Behavior Sciences, 12, 1, 51, 51, Sep. 2013
日本健康行動科学会, Japanese

片脚立位パフォーマンスの再現性における加齢の影響について
萬井 太規, Hsiao Shih-Fen, 長谷川 直哉, 戸塚 満久, 津田 章代, 武田 賢太, 大橋 哲朗, 諏訪原 司, 伊藤 久美子, 趙 静, 浅賀 忠義, Health and Behavior Sciences, 12, 1, 56, 56, Sep. 2013
日本健康行動科学会, Japanese

Characteristics of Stability Limits and Pressure Distributions during Reaching Movements in Patients with Stroke　　　　　　　　　　　　　　　
Tsuda A, Hasegawa N, The 6th Asia-Western Pacific Regional Congress of the World Confederation for Physical Therapy & The 12th International Congress of Asian Confederation for Physical Therapy (WCPT-AWP & ACPT Congress 2013), Sep. 2013
English

Adaptation of postural strategy with a mobile base of support　　　　　　　　　　　　　　　
Mani H, Hasegawa N, The 6th Asia-Western Pacific Regional Congress of the World Confederation for Physical Therapy & The 12th International Congress of Asian Confederation for Physical Therapy (WCPT-AWP & ACPT Congress 2013), Sep. 2013
English

Gait, balance, and mobility analysis : theoretical, technical, and clinical applications
Stuart, Samuel (Dr), Morris, Rosie, CHAPTER 2: Underlying control of balance
Academic Press, an imprint of Elsevier,Array, 2025, 9780443214844, xxv, 499 pages, English, Scholarly book, ［Internationally co-authored］, [Joint work]

図解 理学療法検査・測定ガイド 第3版
内山靖;長谷川直哉, 協調運動
文光堂, Feb. 2023, 9784830647048, 395-409, Japanese, Scholarly book, [Joint work]

理学療法評価学
中山, 恭秀, 長谷川直哉, バランス
メジカルビュー社, Mar. 2022, 9784758320009, 19,409p, 139-148, Japanese, Scholarly book, [Joint work]

Augmented Sensory Biofeedback for Dynamic Postural Control: Visual vs. Auditory
Tadayoshi Asaka, Naoya Hasegawa
Eliva Press, Mar. 2021, 9789975154826, 46, 46, English, Scholarly book, 13888646, [Joint work]

姿勢制御と運動学習 共催シンポジウム3 （日本前庭理学療法研究会 合同企画）「姿勢制御研究をどう臨床に活かすか」.
長谷川直哉
第21回日本神経理学療法学会学術大会, 10 Sep. 2023, Japanese, Nominated symposium
09 Sep. 2023 - 10 Sep. 2023, 13888646, [Invited], [Domestic Conference]

パーキンソン病患者の予測的姿勢調節の病態とそのアプローチ 公募型シンポジウム2「予測的姿勢調節の機能低下のメカニズムから今後の理学療法アプローチを考える」
長谷川直哉
第21回日本神経理学療法学会学術大会, 09 Sep. 2023, Japanese, Public symposium
09 Sep. 2023 - 10 Sep. 2023, 31407822, [Invited], [Domestic Conference], ［Internationally co-authored］

Effects of useful field of view by cognitive loads for postural stability of a stable and unstable surface
Ami Kawata, Naoya Hasegawa
ISPGR World Congress 2023, 10 Jul. 2023, English
09 Jul. 2023 - 13 Jul. 2023, 31407822, [International presentation]

The effects by difference in difficulties of cognitive loads in dual-task training on performance of stepping task with cognitive loads　　　　　　　　　　　　　　　
Yusuke Sakaki, Naoya Hasegawa
ISPGR World Congress 2023, 10 Jul. 2023, English, Poster presentation
09 Jul. 2023 - 13 Jul. 2023, [International presentation]

Impacts of a loss of binocular or motion parallax on static postural stability
Naoya Hasegawa
ISPGR World Congress 2023, 10 Jul. 2023, English, Poster presentation
09 Jul. 2023 - 13 Jul. 2023, 43275080, [International presentation]

Integrated Allied Healthcare For Healthy Ageing: Interprofessional Collaborative Practice, Education and Research
Marianne Coleman, Naoya Hasegawa
ANZAHPE 2023, 27 Jun. 2023, English, Poster presentation
26 Jun. 2023 - 29 Jun. 2023, 38506435, [International presentation], ［Internationally co-authored］

パーキンソン病患者における定量的評価の有効性と臨床応用 シンポジウム 7 「基礎研究の臨床への還元 －パーキンソン病への理学療法－」
長谷川直哉
第27回日本基礎理学療法学会学術大会, 02 Oct. 2022, Japanese, Nominated symposium
01 Oct. 2022 - 02 Oct. 2022, 31407822, [Invited], [Domestic Conference], ［Internationally co-authored］

The Role of A Physical Therapist in Medical Care　　　　　　　　　　　　　　　
Naoya Hasegawa
Hokkaido University & The University of Melbourne Case Study Afternoon, 16 Sep. 2022, English, Nominated symposium
16 Sep. 2022 - 16 Sep. 2022, [Invited], [International presentation]

An overview of Medical and Long-term Care System in Japan
Naoya Hasegawa
Hokkaido University & The University of Melbourne Case Study Afternoon, 16 Sep. 2022, English, Nominated symposium
16 Sep. 2022 - 16 Sep. 2022, 38506435, [Invited], [International presentation]

Adaptation effects of continuous and discrete visual feedback training on static postural control: a preliminary study
Naoya Hasegawa
2022 ISPGR World Congress, 07 Jul. 2022, English, Poster presentation
Montreal, Canada, 31407822, [International presentation]

The different effects on motor learning for postural control using visual and auditory biofeedback training
Naoya Hasegawa
5th FHS International Conference, 17 Sep. 2021, English, Nominated symposium
17 Sep. 2021 - 18 Sep. 2021, 13888646, [Invited], [International presentation]

在宅パーキンソン病患者の姿勢制御能力の評価に有効な指標の検討
長谷川直哉
第25回日本基礎理学療法学会学術大会, 13 Dec. 2020, Japanese, Oral presentation
12 Dec. 2020 - 13 Dec. 2020, 31407822

在宅パーキンソン病患者に対する認知課題を伴うMultiple trainingが姿勢制御能力に与える効果
長谷川直哉
第18回日本神経理学療法学会学術大会, 28 Nov. 2020, Japanese, Oral presentation
28 Nov. 2020 - 29 Nov. 2020, 31407822

断続的なフィードバック練習に用いる感覚の違いが姿勢バランス課題の運動学習に与える影響について　　　　　　　　　　　　　　　
長谷川 直哉
第24回日本基礎理学療法学会学術大会, 01 Dec. 2019, Japanese
[Domestic Conference]

Learning Effects of Visual and Auditory Feedback Training on Voluntarily Postural Control　　　　　　　　　　　　　　　
Hasegawa N
Neuroscience 2019, 23 Oct. 2019, English
[International presentation]

Effects of an agility exercise program with cognitive challenges on objective measures of gait and balance in people with Parkinson’s disease　　　　　　　　　　　　　　　
Carlson-Kuhta P, Hasegawa N
Neuroscience 2019, Oct. 2019, English
Oct. 2019 - Oct. 2019

Multiple domains of postural control in Parkinson’s disease; feature selection of mobility measures　　　　　　　　　　　　　　　
King LA, Hasegawa N
Neuroscience 2019, Oct. 2019, English
Oct. 2019 - Oct. 2019

Turning features in people with Parkinson’s disease, spinocerebellar ataxia, and healthy control subjects　　　　　　　　　　　　　　　
Shah VV, Hasegawa N
Neuroscience 2019, Oct. 2019, English
Oct. 2019 - Oct. 2019

Role of ventricle volume in the association between cognitive status and mobility metrics in Parkinson’s disorders: A mediation analysis　　　　　　　　　　　　　　　
Ragothamani A, Hasegawa N
Neuroscience 2019, Oct. 2019, English
Oct. 2019 - Oct. 2019, ［Internationally co-authored］

Functional Limits of Stability and Standing Balance in People with and without Freezing of Gait　　　　　　　　　　　　　　　
Hasegawa N
2019 International Parkinson and Movement Disorder Society Congress, 24 Sep. 2019, English
[International presentation]

Effects of Cognitively Challenging Agility Exercise Program on Clinical and Objective Measures in People with Parkinson’s Disease　　　　　　　　　　　　　　　
Carlson-Kuhta P, Hasegawa N
2019 International Parkinson and Movement Disorder Society Congress, Sep. 2019, English
Sep. 2019 - Sep. 2019

[Lecture] Parkinson’s Foundation Physical Therapy Faculty Program　　　　　　　　　　　　　　　
Hasegawa N
Oregon Health & Science University, 08 Aug. 2019, English, Public discourse
[Invited]

Feature Selection of Mobility Metrics of Balance Dysfunction in Parkinson’s Disease　　　　　　　　　　　　　　　
Hasegawa N
2019 ISPGR World Congress, 04 Jul. 2019, English
[International presentation]

Effects of a 6-week cognitively challenging agility exercise program in people with Parkinson's disease　　　　　　　　　　　　　　　
Horak FB, Hasegawa N
2019 ISPGR World Congress, Jun. 2019, English
Jun. 2019 - Jun. 2019

Feature Selection of Objective Metrics of Balance Dysfunction in Parkinson’s Disease　　　　　　　　　　　　　　　
Hasegawa N
OHSU Research Week 2019, 14 May 2019, English
[International presentation]

[English] 動的バランスにおける感覚フィードバック練習の学習効果の違い　　　　　　　　　　　　　　　
長谷川 直哉
第3回北大・部局横断シンポジウム 研究ネットワーク促進プログラム, 26 Jan. 2018, English
[Invited], [Domestic Conference]

Adaptation effects of postural control during standing on a tilting board in patients with Parkinson’s disease　　　　　　　　　　　　　　　
Hasegawa N
The Third FHS International Conference, 07 Jul. 2017, English
[International presentation]

Influences of visual field loss for postural stability during quiet standing in healthy young adults　　　　　　　　　　　　　　　
Taneda K, Hasegawa N
The Third FHS International Conference, Jul. 2017, English
Jul. 2017 - Jul. 2017

傾斜台上立位保持がパーキンソン病患者の安定性限界と歩行に与える即時効果　　　　　　　　　　　　　　　
長谷川 直哉
第52回日本理学療法学術大会, 12 May 2017, Japanese
[Domestic Conference]

Different learning effects of dynamic postural control by visual or auditory feedback training　　　　　　　　　　　　　　　
Hasegawa N
Neuroscience 2016, 14 Nov. 2016, English
[International presentation]

Cortical processes to predict timing gait initiation through visual information　　　　　　　　　　　　　　　
Takeda K, Hasegawa N
Neuroscience 2016, Nov. 2016, English
Nov. 2016 - Nov. 2016

Effects of visual feedback training using center of gravity along with center of pressure for static postural balance　　　　　　　　　　　　　　　
Mani H, Hasegawa N
Neuroscience 2016, Nov. 2016, English
Nov. 2016 - Nov. 2016

周期的な動作課題における視覚と聴覚フィードバック練習の学習効果の違い　　　　　　　　　　　　　　　
長谷川 直哉
日本健康行動科学会第15回学術大会, 11 Sep. 2016, Japanese
[Domestic Conference]

［講師］基礎研究体験フォーラム　　　　　　　　　　　　　　　
長谷川 直哉
日本理学療法士協会, 07 Mar. 2015, Japanese, Public discourse
[Invited]

Different effects of motor learning between visual and auditory feedback exercises in dynamic postural balance　　　　　　　　　　　　　　　
Hasegawa N
The 1st Asia - Pacific Conference on Coaching Science, 12 Jul. 2014, English
[International presentation]

感覚フィードバックの違いが動的バランスの学習効果に与える影響　　　　　　　　　　　　　　　
長谷川 直哉
第49回日本理学療法学術大会, 30 May 2014, Japanese
[Domestic Conference]

Learning effects of dynamic postural balance by visual or auditory feedback exercise　　　　　　　　　　　　　　　
Hasegawa N
The 67th Congress of the Taiwan Physical Therapy Association, 29 Mar. 2014, English
[International presentation]

感覚フィードバックの違いが動的バランスの運動学習に与える影響について　　　　　　　　　　　　　　　
長谷川 直哉
日本健康行動科学会第12回学術大会, 28 Sep. 2013, Japanese
[Domestic Conference]

Introduction to Biomedical Measurements and Instrumentation　　　　　　　　　　　　　　　
Apr. 2025 - Present

Activities of Daily Living Practice　　　　　　　　　　　　　　　
Apr. 2023 - Present

Clinical Kinesiology　　　　　　　　　　　　　　　
Hokkaido University
Apr. 2023 - Present

ADL in relation to QOL　　　　　　　　　　　　　　　
Hokkaido University
Apr. 2022 - Present

Physiology for Rehabilitation　　　　　　　　　　　　　　　
Hokkaido University
Apr. 2022 - Present

Study method of physical therapy　　　　　　　　　　　　　　　
Hokkaido University
May 2020 - Present

Evaluation in Physical Therapy　　　　　　　　　　　　　　　
Hokkaido University
May 2020 - Present

Clinical Practice　　　　　　　　　　　　　　　
実習前後OSCE，CBTの作成・管理
May 2020 - Present

Practice in Kinesiology　　　　　　　　　　　　　　　
Hokkaido University
May 2020 - Present

Neurotherapeutics　　　　　　　　　　　　　　　
Hokkaido University
May 2020 - Present

Seminar on Physical Therapy　　　　　　　　　　　　　　　
Hokkaido University
May 2020 - Present

Seminar on Motor control　　　　　　　　　　　　　　　
Hokkaido University
May 2020 - Present

Introduction to physical therapy　　　　　　　　　　　　　　　
May 2020 - Mar. 2022

Supervisor of Clinical training　　　　　　　　　　　　　　　
Sapporo Yamanoue Hospital
Apr. 2014 - Aug. 2018

Jul. 2021 - Present
日本神経理学療法学会　　　　　　　　　　　　　　　

Jul. 2021 - Present
日本基礎理学療法学会　　　　　　　　　　　　　　　

Jan. 2019 - Present
International Society of Posture & Gait Research　　　　　　　　　　　　　　　

Jan. 2019 - Present
International Parkinson and Movement Disorder Society　　　　　　　　　　　　　　　

Jan. 2019 - Present
Society for Neuroscience　　　　　　　　　　　　　　　

Apr. 2012 - Present
北海道理学療法士協会　　　　　　　　　　　　　　　

Apr. 2012 - Present
JAPANESE PHYSICAL THERAPY ASSOCIATION　　　　　　　　　　　　　　　

Developing and Implementing Health Promotion Strategies to Extend Healthy Lifespan: A Japan-Australia Collaboration
Grants-in-Aid for Scientific Research
09 Sep. 2024 - 31 Mar. 2029
澤村 大輔, 石塚 敏, 矢野 理香, 長谷川 直哉, 稲垣 侑士
Japan Society for the Promotion of Science, Fund for the Promotion of Joint International Research (International Collaborative Research), Hokkaido University, 24KK0038

Development of a novel learning system to correct atypical anticipatory postural adjustments in developmental coordination disorders.
Grants-in-Aid for Scientific Research
01 Apr. 2024 - 31 Mar. 2028
萬井 太規, 阿南 雅也, 菅田 陽怜, 徳丸 治, 宮城島 沙織, 長谷川 直哉
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (B), Oita University, 24K02423

Developing a new effective intervention for postural instability using thermotherapy
Grants-in-Aid for Scientific Research
01 Apr. 2024 - 31 Mar. 2028
長谷川 直哉
Japan Society for the Promotion of Science, Grant-in-Aid for Early-Career Scientists, Hokkaido University, 24K20491

Development of novel effective interventions using transcutaneous vagus nerve stimulation for postural instability in Parkinson's disease
Grants-in-Aid for Scientific Research
01 Apr. 2023 - 31 Mar. 2027
岡田 洋平, 形岡 博史, 西 祐樹, 長谷川 直哉
令和5年度は、研究実施において必須となる迷走神経刺激装置や日常生活における姿勢不安定性を評価するための加速度センサーやセンサー装着の為のベルトなどの環境整備、共同研究者との研究計画の詳細の決定、畿央大学および研究協力機関における研究倫理委員会の承認を得て、研究を実施可能な体制を整備した。
その上で、パーキンソン病患者二症例に対して、経耳的迷走神経刺激を行い、偽刺激の効果と比較検証を行った。二症例とも刺激による副作用はなく、問題なく検証可能であった。うち一症例において、実刺激単一セッション後に日常生活の歩行変動性や左右非対称性が改善することを確認した。もう一症例は、腰部整形疾患を合併しており、実刺激による運動症状の顕著な改善は認めなかったが、夜間の睡眠障害に顕著な改善を認めた。これらの結果は、令和6年度に理学療法およびパーキンソン病関連の学会および国際誌において予備的な結果として公表する予定である。
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Kio University, 23K10549

The effects by difference in difficulties of cognitive loads in dual-task training on performance of stepping task with cognitive loads　　　　　　　　　　　　　　　
伊藤財団 2023 年度研究助成金(A.交流助成)
Aug. 2023 - Mar. 2024
公益財団法人伊藤医薬学術交流財団, 北海道大学 大学院保健科学研究院, Coinvestigator, Others

Impacts of a loss of binocular or motion parallax on static postural stability
伊藤財団 2023 年度研究助成金(A.交流助成)
Aug. 2023 - Mar. 2024
公益財団法人伊藤医薬学術交流財団, 北海道大学 大学院保健科学研究院, Principal investigator, Competitive research funding

Developments of Sensory Feedback Training Methods for Freezing of Gait in People with Parkinson's Disease
Grant-in-Aid for Scientific Research
Apr. 2020 - Mar. 2024
Naoya Hasegawa
本研究の目的は，パーキンソン病患者の主要症状であるすくみ足や姿勢制御障害の改善を目的として，運動学習に着目した新たな感覚フィードバック練習を考案することだった。対象となるすくみ足のあるパーキンソン病患者について姿勢バランス能力の検証を行い，健常高齢者およびすくみ足のないパーキンソン病患者と比較して安定性限界と呼ばれる重心の最大移動範囲が狭小化している一方で，立位時の動揺範囲など静止立位における姿勢制御能力はすくみ足のないパーキンソン病患者と比較して大きな差がないことを報告した。従って，パーキンソン病患者におけるすくみ足に最大重心移動範囲の狭小化が関係している可能性が示唆された。本研究の成果は，Gait ＆ Postureに掲載された。
さらに，上述した安定性限界のうち前方への安定性限界の狭小化に対して，母趾だけでなく，第二趾が大きな影響を与えることを健常若年者を対象とした研究によって示した。本研究の成果は，Health and Behavior Sciencesに掲載された。
また，健常若年者を対象に外乱に対する代償的なステッピングの練習効果を比較検証した。その結果，外乱が生じる方向を事前に教示したステッピング練習でも方向を事前に教示しないステッピング練習と同程度の練習効果を外乱の方向およびタイミングを教示しない外乱刺激に対して示すことを報告した。従って，より安全性の高い外乱の方向を教示した練習方法でもステッピング練習の効果が得られることが示唆され，姿勢制御能力に障害があるパーキンソン病患者に対する応用の可能性が示された。本研究の成果はFrontiers in Human Neuroscienceに掲載された。
Japan Society for the Promotion of Science, Early-Career Scientists, Hokkaido University, Principal investigator, 20K19371

Developing an interdisciplinary component to research-informed international education of the future geriatric allied health worker.
北海道大学 - メルボルン大学合同研究ワークショップファンド
Jul. 2022 - Mar. 2023
Sawamura D, Coleman M, Hasegawa N
Coinvestigator, Competitive research funding, ［Internationally co-authored］

Learning effects of postural control by auditory biofeedback
Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Apr. 2018 - Mar. 2023
浅賀 忠義, 長谷川 直哉, 武田 賢太
断続的な聴覚および視覚フィードバック (FB)の動的バランスにおける学習効果について比較することを目的に実験を実施した．対象は健常若年者22名で，ランダムに2群（聴覚FB群，視覚FB群）に分けられた．随意的なBody sway課題を実施し，その学習効果について比較した．足圧中心位置とターゲットとのコヒーレンスの結果から，聴覚FB群の方が視覚FB群と比べて学習効果が高いことが示された．この結果は，前回我々が報告した連続的な感覚FBを用いた結果と同様であった．本研究成果は，Society for Neuroscience 2019 (USA)で発表予定である．
パーキンソン病 (PD) 患者を対象にFBの練習効果の確認指標を決定することを目的に研究を行った．対象は，PD患者142名（年齢：68±8歳）と健常高齢者76名（年齢：68±8歳）だった．静的および動的バランスの課題を実施した．ランダムフォレストアルゴリズムを用いて57の指標の中から最も感度の高い4つの指標を抽出した．本研究成果は，International Society of Posture & Gait research 2019 (UK)で発表予定である，
PD患者においてすくみ足 (FoG) の有無が安定性限界や姿勢バランスに影響するか否かについて調べることを目的に研究を行った．対象は，FoG が観られるPD患者64名（PD+FoG; 年齢：68±8歳），FoG が観られないPD患者80名（PD-FoG; 年齢：69±8歳）および健常高齢者79名（HC; 年齢：68±8歳）だった．安定性限界において，PD+FoGはPD-FoG とHCよりも有意に小さいことが示された．一方，安静立位時における姿勢動揺には有意差が認められなかった．本研究成果は，Parkinson and Movement Disorder Society 2019 (France)で発表予定である．
Japan Society for the Promotion of Science, Grant-in-Aid for Scientific Research (C), Hokkaido University, Competitive research funding, 18K10702

バランス DE 転倒予防　　　　　　　　　　　　　　　
Aug. 2022 - Present
Lecturer, Planner
介護予防センター旭ヶ丘
札幌市中央区介護予防教室
General
介護予防センター旭ヶ丘に登録されている65歳以上の高齢者に対して，バランス機能に関する講演や転倒予防に関する講演を年3回実施するとともに，定期的なバランス機能の計測およびフィードバックを実施。

耳ってすごい
Aug. 2025
Myself
FM North Wave
cottonsky
聴覚がもたらす機能の概要から聴覚フィードバックを用いた運動が将来的にもたらす可能性について講演。, 31407822, [Media report]

健康けっこう！調べ隊　　　　　　　　　　　　　　　
May 2021
Myself
HTB
イチモニ
「イチモニ!」の「健康けっこう！調べ隊」のコーナー内で転倒予防に効果のある運動方法などを実演。, [Media report]

健康けっこう！調べ隊　　　　　　　　　　　　　　　
Dec. 2020
ＨＴＢ
イチモニ!
「イチモニ!」の「健康けっこう！調べ隊」のコーナー内で転倒予防に効果のある運動方法などを実演。, [Media report]