Changes in Toe Clearance Due to Adjusting the Dorsiflexion Angle of Ankle-Foot Orthoses: A Study in Healthy Individuals.
Hiroshi Hosokawa, Fumiaki Tamiya, Ren Fujii, Ryu Ishimoto, Masahiko Mukaino, Yohei Otaka
Bioengineering (Basel, Switzerland), 11, 12, 2024年12月20日, ［国際誌］
英語, 研究論文（学術雑誌）, This study investigated the effects of ankle dorsiflexion angle adjustments in ankle-foot orthoses (AFOs) on the gait of healthy individuals. Fifteen healthy participants engaged in treadmill walking tasks while wearing AFOs with dorsiflexion angles set at 0°, 5°, 10°, and 15°. Three-dimensional treadmill gait analysis was used to collect data during treadmill walking. The analysis focused on toe clearance and the contribution of the vertical component of limb shortening (LS), and compared them across different dorsiflexion angles. The results indicated a significant increase in toe clearance at 10° (median [interquartile change]: 5.03 [0.90] vs. 5.98 [1.18], p < 0.01) and 15° (5.03 [0.90] vs. 5.82 [1.11], p < 0.01) dorsiflexion angle conditions compared to the 0° condition. Similarly, LS demonstrated significant increases at 10° (4.89 [1.97] vs. 5.87 [1.31], p < 0.01) and 15° (4.89 [1.97] vs. 5.61 [1.65], p < 0.01) conditions when compared with the 0° condition. These findings support the notion that higher dorsiflexion angles in AFOs lead to increased toe clearance and LS, suggesting the effectiveness of dorsiflexion angle adjustments as a strategy to address reduced toe clearance.

Phase I/II trial of intracerebral transplantation of autologous bone marrow stem cells combined with recombinant peptide scaffold for patients with chronic intracerebral haemorrhage: a study protocol.
Masahito Kawabori, Hideo Shichinohe, Kaoru Kahata, Arisa Miura, Kenichiro Maeda, Yoichi M Ito, Masahiko Mukaino, Ryo Kogawa, Kentaro Nakamura, Shuho Gotoh, Kota Kurisu, Miki Fujimura
BMJ open, 14, 12, e083959, 2024年12月02日, ［国際誌］
英語, 研究論文（学術雑誌）, INTRODUCTION: Intracerebral haemorrhage (ICH) stands as a leading global cause of death and disability, posing a significant challenge with limited treatment options, especially for chronic patients. Recent advances in stem cell therapies have opened new avenues for therapeutic potential. Our previous preclinical research has demonstrated that intracerebral transplantation of bone marrow stromal cells (BMSCs) combined with a recombinant human collagen type I scaffold enables higher cell survival and engraftment and holds promising potential. In this article, we present the protocol for a novel clinical trial, named 'Research on Advanced Intervention using Novel Bone MarrOW stem cells for chronic intracerebral haemorrhage' (RAINBOW-Hx). METHODS AND ANALYSIS: RAINBOW-Hx is a phase I/II, open-label, uncontrolled study with the primary objective of assessing the safety and efficacy of intracerebral transplantation of autologous BMSCs combined with the scaffold (HUFF-01) in patients with chronic ICH. Eight patients, experiencing moderate to severe neurological deficits for 12 months or longer, will be enrolled. The haemorrhage location will be limited to the basal ganglia and thalamus. Approximately 50 mL of bone marrow will be extracted from the iliac bone of each patient, and BMSCs will be cultured using autologous platelet lysate. 3 days before transplantation, BMSCs will be combined with the scaffold to generate HUFF-01. Each patient will receive a 50 000 HUFF-01 dose, containing approximately 50 million BMSCs, through stereotactic transplantation into the haemorrhagic cavity. Neurological assessments, MRI, 18F-fluorodeoxyglucose positron emission tomography and 123I-Iomazenil single-photon emission CT will be performed for 1 year after administration. ETHICS AND DISSEMINATION: The trial protocols were reviewed and approved by the Institutional Review Board of the Hokkaido University Hospital (R5-11), and this study is conducted according to Good Clinical Practice guidelines and the principles of the Declaration of Helsinki. The results of this trial will be submitted for publication in a peer-reviewed scientific journal. TRIAL REGISTRATION NUMBER: jRCT2013230053, Japan Registry of Clinical Trials.

Posterior Correction and Fusion Using a 4D Anatomical Spinal Reconstruction Technique Improves Postural Stability Under the Eye-Closed Condition in Patients with Adolescent Idiopathic Scoliosis.
Satoshi Osuka, Hideki Sudo, Katsuhisa Yamada, Hiroyuki Tachi, Akira Fukushima, Hiroki Mani, Kentaro Watanabe, Fuma Sentoku, Takeshi Chiba, Hiroaki Hori, Norimasa Iwasaki, Masahiko Mukaino, Harukazu Tohyama
Journal of clinical medicine, 13, 21, 2024年10月24日, ［国際誌］
英語, 研究論文（学術雑誌）, Background: Patients with adolescent idiopathic scoliosis (AIS) has been reported to exhibit impaired postural stability. Posterior correction and fusion using four-dimensional (4D) anatomical spinal reconstruction techniques may improve postural stability to correct the spine for optimal anatomical alignment. This prospective study aimed to determine the effect of posterior correction and fusion using a 4D anatomical spinal reconstruction technique on postural stability in the eye-open and eye-closed standing position in patients with thoracic AIS. Methods: Thirty-three patients with AIS, excluding those with Lenke type 5C AIS, participated in the study. The mean and standard deviation of the minimum values of the time-to-boundary (TTB) were determined. All patients were asked to perform the quiet standing position under the eye-open and eye-closed condition on a force plate preoperatively and at 1 week and 2 years postoperatively. The TTB value was calculated from the velocity and distance to the foot boundary of the acquired center-of-pressure data. Results: Under the eye-closed condition, the mean and standard deviation of the minimum TTB were significantly higher at 2 years postoperatively than preoperatively and at 1 week postoperatively. The mean and standard deviation of the minimum TTB values were significantly lower at 1 week postoperatively than preoperatively. Conclusions: The results of this study suggest that surgery using the 4D anatomical spinal reconstruction technique reduces postural stability immediately after surgery; however, it improves postural stability at 2 years compared to the preoperative values.

Cervical motion analysis using wearable inertial sensors to patients with cervical ossification of posterior longitudinal ligament.
Satoshi Osuka, Masahiko Takahata, Ryo Takeda, Takeshi Chiba, Hiroaki Hori, Yoshiaki Kataoka, Norimasa Iwasaki, Masahiko Mukaino, Harukazu Tohyama
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2024年09月29日, ［国際誌］
英語, 研究論文（学術雑誌）, This study aimed to clarify cervical kinematics during daily activities, including level walking and stair ascending, in patients with cervical ossification of the posterior longitudinal ligament (C-OPLL). Eighteen patients with myelopathy caused by C-OPLL and 18 healthy controls were recruited to participate in the study. The sagittal cervical kinematics during level walking and stair ascent were quantitatively assessed using a motion analysis system based on wearable inertial sensors. The Japanese Orthopaedic Association score, Japanese Orthopaedic Association Cervical Myelopathy Evaluation Questionnaire, Neck Disability Index, and deep sensation in the lower extremities were assessed in all participants. Nine of 18 patients with C-OPLL presented with deep sensory disturbances. Patients with C-OPLL with deep sensory disturbances exhibited different sagittal plane cervical motion patterns than healthy controls during level walking and stair ascent. During the first phase of stair ascent, both patients with C-OPLL and healthy controls flexed their necks to the same degree; however, during the middle and final phases of stair ascent and all phases of level walking, the mean cervical flexion angle of patients with C-OPLL with deep sensory disturbances was significantly higher than that of patients with C-OPLL without deep sensory disturbance and healthy controls. Our data suggest that patients with C-OPLL presenting with deep sensory disturbances are likely to walk with their necks flexed and gaze downward to observe their steps throughout their daily lives. This habitual neck posture may lead to a vicious cycle of cervical kyphosis and worsening of compressive myelopathy.

Response to the letter to the editor: clinical impact of non-lying time on hospital-associated functional decline in older patients undergoing transcatheter aortic valve implantation.
Yuji Kono, Masahiko Mukaino, Yushi Ozawa, Koji Mizutani, Yuki Senju, Takayuki Ogasawara, Masumi Yamaguchi, Takashi Muramatu, Hideo Izawa, Yohei Otaka
Heart and vessels, 2024年06月03日, ［国内誌］
英語

Highlighting Unseen Activity Through 48-Hour Continuous Measurement in Subacute Stroke Rehabilitation: Preliminary Cohort Study.
Emi Mizuno, Takayuki Ogasawara, Masahiko Mukaino, Masumi Yamaguchi, Shingo Tsukada, Shigeru Sonoda, Yohei Otaka
JMIR formative research, 8, e51546, 2024年05月29日, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: Motor impairments not only lead to a significant reduction in patient activity levels but also trigger a further deterioration in motor function due to deconditioning, which is an issue that is particularly pronounced during hospitalization. This deconditioning can be countered by sustaining appropriate activity levels. Activities that occur outside of scheduled programs, often overlooked, are critical in this context. Wearable technology, such as smart clothing, provides a means to monitor these activities. OBJECTIVE: This study aimed to observe activity levels in patients who had strokes during the subacute phase, focusing on both scheduled training sessions and other nontraining times in an inpatient rehabilitation environment. A smart clothing system is used to simultaneously measure heart rate and acceleration, offering insights into both the amount and intensity of the physical activity. METHODS: In this preliminary cohort study, 11 individuals undergoing subacute stroke rehabilitation were enrolled. The 48-hour continuous measurement system, deployed at admission and reassessed 4 weeks later, monitored accelerometry data for physical activity (quantified with a moving SD of acceleration [MSDA]) and heart rate for intensity (quantified with percent heart rate reserve). The measurements were performed using a wearable activity monitoring system, the hitoe (NTT Corporation and Toray Industries, Inc) system comprising a measuring garment (wear or strap) with integrated electrodes, a data transmitter, and a smartphone. The Functional Independence Measure was used to assess the patients' daily activity levels. This study explored factors such as differences in activity during training and nontraining periods, correlations with activities of daily living (ADLs) and age, and changes observed after 4 weeks. RESULTS: A significant increase was found in the daily total MSDA after the 4-week program, with the average percent heart rate reserve remaining consistent. Physical activity during training positively correlated with ADL levels both at admission (ρ=0.86, P<.001) and 4 weeks post admission (ρ=0.96, P<.001), whereas the correlation between age and MSDA was not significant during training periods at admission (ρ=-0.41, P=.21) or 4 weeks post admission (ρ=-0.25, P=.45). Conversely, nontraining activity showed a negative correlation with age, with significant negative correlations with age at admission (ρ=-0.82, P=.002) and 4 weeks post admission (ρ=-0.73, P=.01). CONCLUSIONS: Inpatient rehabilitation activity levels were positively correlated with ADL levels. Further analysis revealed a strong positive correlation between scheduled training activities and ADL levels, whereas nontraining activities showed no such correlation. Instead, a negative correlation between nontraining activities and age was observed. These observations suggest the importance of providing activity opportunities for older patients, while it may also suggest the need for adjusting the activity amount to accommodate the potentially limited fitness levels of this demographic. Future studies with larger patient groups are warranted to validate and further elucidate these findings.

Development of a Conversion Table Linking Functional Independence Measure Scores to International Classification of Functioning, Disability, and Health Qualifiers: Insights from a Survey of Healthcare Professionals.
Shu Umemori, Mao Ogawa, Shin Yamada, Masayo Komatsu, Emiko Oikawa, Yasuyo Okamoto, Masaki Katoh, Tomohide Shirasaka, Kagari Abiko, Shigehiro Moriizumi, Yuichiro Matsuo, Harukazu Tohyama, Masahiko Mukaino
Healthcare (Basel, Switzerland), 12, 8, 2024年04月15日, ［国際誌］
英語, 研究論文（学術雑誌）, In clinical practice, patient assessments rely on established scales. Integrating data from these scales into the International Classification of Functioning, Disability, and Health (ICF) framework has been suggested; however, a standardized approach is lacking. Herein, we tested a new approach to develop a conversion table translating clinical scale scores into ICF qualifiers based on a clinician survey. The survey queried rehabilitation professionals about which functional independence measure (FIM) item scores (1-7) corresponded to the ICF qualifiers (0-4). A total of 458 rehabilitation professionals participated. The survey findings indicated a general consensus on the equivalence of FIM scores with ICF qualifiers. The median value for each item remained consistent across all item groups. Specifically, FIM 1 had a median value of 4; FIM 2 and 3 both had median values of 3; FIM 4 and 5 both had median values of 2; FIM 6 had a median value of 1; and FIM 7 had a median value of 0. Despite limitations due to the irreconcilable differences between the frameworks of existing scales and the ICF, these results underline the ICF's potential to serve as a central hub for integrating clinical data from various scales.

Functional outcomes of protocol-based rehabilitation for patients with coronavirus disease 2019 in an acute care setting.
Yoshitaka Wada, Seiko Shibata, Ayato Shinohara, Koji Mizutani, Masahiko Mukaino, Yohei Otaka
Fujita medical journal, 10, 1, 35, 42, 2024年02月, ［国内誌］
英語, 研究論文（学術雑誌）, OBJECTIVES: To examine the functional outcomes of patients with coronavirus disease 2019 (COVID-19) who underwent a new protocol-based rehabilitation program. METHODS: In this retrospective cohort study, we enrolled patients who were hospitalised in a university hospital in Japan because of COVID-19 from 1st September, 2020-5th July, 2021. The primary outcome was the Functional Independence Measure (FIM) subtotal score for motor items at discharge. The secondary outcomes included the FIM cognitive subtotal score, length of hospital stay, rehabilitation period, total rehabilitation time, final rehabilitation protocol level, and discharge destination. RESULTS: Of the 78 enrolled patients (49 men; mean age [standard deviation], 70.3 [13.9] years), 24 died (30.8%) during hospitalisation. Disease severity was classified as mild, moderate I, moderate II, and severe in 1, 6, 41, and 30 patients, respectively. The FIM motor subtotal score differed significantly among groups for all participants (p=0.027). Post hoc analysis revealed that the FIM motor subtotal score in the severe group was significantly lower than that in the moderate II group (p=0.030). CONCLUSIONS: Disease severity significantly affected patients' functional outcome for COVID-19 at discharge. Our protocol-based program provides a benchmark for COVID-19 rehabilitation in an acute care setting.

Prediction of stroke patients’ bedroom-stay duration: machine-learning approach using wearable sensor data
Takayuki Ogasawara, Masahiko Mukaino, Kenichi Matsunaga, Yoshitaka Wada, Takuya Suzuki, Yasushi Aoshima, Shotaro Furuzawa, Yuji Kono, Eiichi Saitoh, Masumi Yamaguchi, Yohei Otaka, Shingo Tsukada
Frontiers in Bioengineering and Biotechnology, 11, Frontiers Media SA, 2024年01月03日
研究論文（学術雑誌）, Background: The importance of being physically active and avoiding staying in bed has been recognized in stroke rehabilitation. However, studies have pointed out that stroke patients admitted to rehabilitation units often spend most of their day immobile and inactive, with limited opportunities for activity outside their bedrooms. To address this issue, it is necessary to record the duration of stroke patients staying in their bedrooms, but it is impractical for medical providers to do this manually during their daily work of providing care. Although an automated approach using wearable devices and access points is more practical, implementing these access points into medical facilities is costly. However, when combined with machine learning, predicting the duration of stroke patients staying in their bedrooms is possible with reduced cost. We assessed using machine learning to estimate bedroom-stay duration using activity data recorded with wearable devices.

Method: We recruited 99 stroke hemiparesis inpatients and conducted 343 measurements. Data on electrocardiograms and chest acceleration were measured using a wearable device, and the location name of the access point that detected the signal of the device was recorded. We first investigated the correlation between bedroom-stay duration measured from the access point as the objective variable and activity data measured with a wearable device and demographic information as explanatory variables. To evaluate the duration predictability, we then compared machine-learning models commonly used in medical studies.

Results: We conducted 228 measurements that surpassed a 90% data-acquisition rate using Bluetooth Low Energy. Among the explanatory variables, the period spent reclining and sitting/standing were correlated with bedroom-stay duration (Spearman’s rank correlation coefficient (R) of 0.56 and −0.52, p &lt; 0.001). Interestingly, the sum of the motor and cognitive categories of the functional independence measure, clinical indicators of the abilities of stroke patients, lacked correlation. The correlation between the actual bedroom-stay duration and predicted one using machine-learning models resulted in an R of 0.72 and p &lt; 0.001, suggesting the possibility of predicting bedroom-stay duration from activity data and demographics.

Conclusion: Wearable devices, coupled with machine learning, can predict the duration of patients staying in their bedrooms. Once trained, the machine-learning model can predict without continuously tracking the actual location, enabling more cost-effective and privacy-centric future measurements.

Movement Component Analysis of Reaching Strategies in Individuals With Stroke: Preliminary Study
Hirofumi Ota, Masahiko Mukaino, Yukari Inoue, Shoh Matsuura, Senju Yagi, Yoshikiyo Kanada, Eiichi Saitoh, Yohei Otaka
JMIR Rehabilitation and Assistive Technologies, 10, e50571, e50571, JMIR Publications Inc., 2023年12月05日
研究論文（学術雑誌）, Background

Upper limb motor paresis is a major symptom of stroke, which limits activities of daily living and compromises the quality of life. Kinematic analysis offers an in-depth and objective means to evaluate poststroke upper limb paresis, with anticipation for its effective application in clinical settings.

Objective

This study aims to compare the movement strategies of patients with hemiparesis due to stroke and healthy individuals in forward reach and hand-to-mouth reach, using a simple methodology designed to quantify the contribution of various movement components to the reaching action.

Methods

A 3D motion analysis was conducted, using a simplified marker set (placed at the mandible, the seventh cervical vertebra, acromion, lateral epicondyle of the humerus, metacarpophalangeal [MP] joint of the index finger, and greater trochanter of the femur). For the forward reach task, we measured the distance the index finger’s MP joint traveled from its starting position to the forward target location on the anterior-posterior axis. For the hand-to-mouth reach task, the shortening of the vertical distance between the index finger MP joint and the position of the chin at the start of the measurement was measured. For both measurements, the contributions of relevant upper limb and trunk movements were calculated.

Results

A total of 20 healthy individuals and 10 patients with stroke participated in this study. In the forward reach task, the contribution of shoulder or elbow flexion was significantly smaller in participants with stroke than in healthy participants (mean 52.5%, SD 24.5% vs mean 85.2%, SD 4.5%; P<.001), whereas the contribution of trunk flexion was significantly larger in stroke participants than in healthy participants (mean 34.0%, SD 28.5% vs mean 3.0%, SD 2.8%; P<.001). In the hand-to-mouth reach task, the contribution of shoulder or elbow flexion was significantly smaller in participants with stroke than in healthy participants (mean 71.8%, SD 23.7% vs mean 90.7%, SD 11.8%; P=.009), whereas shoulder girdle elevation and shoulder abduction were significantly larger in participants with stroke than in healthy participants (mean 10.5%, SD 5.7% vs mean 6.5%, SD 3.0%; P=.02 and mean 16.5%, SD 18.7% vs mean 3.0%, SD 10.4%; P=.02, respectively).

Conclusions

Compared with healthy participants, participants with stroke achieved a significantly greater distance via trunk flexion in the forward reach task and shoulder abduction and shoulder girdle elevation in the hand-to-mouth reach task, both of these differences are regarded as compensatory movements. Understanding the characteristics of individual motor strategies, such as dependence on compensatory movements, may contribute to tailored goal setting in stroke rehabilitation.

Effects of ankle-foot orthosis on gait pattern and spatiotemporal indices during treadmill walking in hemiparetic stroke
Kei Ohtsuka, Masahiko Mukaino, Junya Yamada, Matsuda Fumihiro, Hiroki Tanikawa, Kazuhiro Tsuchiyama, Toshio Teranishi, Eiichi Saitoh, Yohei Otaka
International journal of rehabilitation research. Internationale Zeitschrift fur Rehabilitationsforschung. Revue internationale de recherches de readaptation, 46, 4, 316, 324, 2023年12月01日
研究論文（学術雑誌）

Clinical impact of non-lying time on hospital-associated functional decline in older patients undergoing transcatheter aortic valve implantation.
Yuji Kono, Masahiko Mukaino, Yushi Ozawa, Koji Mizutani, Yuki Senju, Takayuki Ogasawara, Masumi Yamaguchi, Takashi Muramatsu, Hideo Izawa, Yohei Otaka
Heart and vessels, 2023年10月16日, ［国内誌］
英語, 研究論文（学術雑誌）, The purposes of the present study were: (1) to investigate the relationship between hospital-associated functional decline (HAFD) and non-lying time and (2) to clarify the optimal cut-off value for non-lying time associated with HAFD in older patients undergoing transcatheter aortic valve implantation (TAVI). From January 2021 to December 2022, patients admitted to a university hospital who underwent trans-femoral TAVI were consecutively recruited. We measured short physical performance battery (SPPB) pre and post-TAVI, and non-lying time from post-operative days 3-5. HAFD was defined as at least 1 point decrease in SPPB during pre and post-TAVI. Among 75 patients (47 female, mean age of 84.5 years) enrolled, 14 patients were classified as having HAFD. Non-lying time was significantly shorter in the HAFD group than in the non-HAFD group (371 min vs. 539 min, P < 0.001). Receiver-operating characteristic analysis determined an optimal cut-off value of 477 min for differentiating the patients more likely to experience HAFD (sensitivity, 75%; specificity, 92%; area under the curve, 0.798). The non-lying time could be one of the associated factors of HAFD in older patients with TAVI. Non-lying time of about 480 min (8 h) during hospitalization may be an initial target for preventing HAFD.

脳出血後の易怒性に対して反復経頭蓋磁気刺激を実施した1例　　　　　　　　　　　　　　　
若林 央樹, 小川 真央, 梅森 秀, 遠山 晴一, 小金丸 聡子, 向野 雅彦
The Japanese Journal of Rehabilitation Medicine, 60, 秋季特別号, S390, S390, (公社)日本リハビリテーション医学会, 2023年10月
日本語

Use of artificial intelligence large language models as a clinical tool in rehabilitation medicine: a comparative test case.
Liang Zhang, Syoichi Tashiro, Masahiko Mukaino, Shin Yamada
Journal of rehabilitation medicine, 55, jrm13373, 2023年09月11日, ［国際誌］
英語, 研究論文（学術雑誌）, OBJECTIVE: To explore the potential use of artificial intelligence language models in formulating rehabilitation prescriptions and International Classification of Functioning, Disability and Health (ICF) codes.  Design: Comparative study based on a single case report compared to standard answers from a textbook. SUBJECTS: A stroke case from textbook.  Methods: Chat Generative Pre-Trained Transformer-4 (ChatGPT-4)was used to generate comprehensive medical and rehabilitation prescription information and ICF codes pertaining to the stroke case. This information was compared with standard answers from textbook, and 2 licensed Physical Medicine and Rehabilitation (PMR) clinicians reviewed the artificial intelligence recommendations for further discussion. RESULTS: ChatGPT-4 effectively formulated rehabilitation prescriptions and ICF codes for a typical stroke case, together with a rationale to support its recommendations. This information was generated in seconds. Compared with standard answers, the large language model generated broader and more general prescriptions in terms of medical problems and management plans, rehabilitation problems and management plans, as well as rehabilitation goals. It also demonstrated the ability to propose specified approaches for each rehabilitation therapy. The language model made an error regarding the ICF category for the stroke case, but no mistakes were identified in the ICF codes assigned.  Conclusion: This test case suggests that artificial intelligence language models have potential use in facilitating clinical practice and education in the field of rehabilitation medicine.

Determinants of Gait Parameters in Patients With Severe Hip Osteoarthritis.
Yoshihiro Ritsuno, Mitsuhiro Morita, Masahiko Mukaino, Kei Otsuka, Arihiko Kanaji, Junya Yamada, Eiichi Saitoh, Morio Matsumoto, Masaya Nakamura, Yohei Otaka, Nobuyuki Fujita
Archives of physical medicine and rehabilitation, 2023年09月07日, ［国際誌］
英語, 研究論文（学術雑誌）, OBJECTIVE: To investigate the characteristics and symptoms of patients with hip osteoarthritis that are associated with spatiotemporal gait parameters, including their variability and asymmetry. DESIGN: A retrospective, cross-sectional study. SETTING: University hospital. PARTICIPANTS: The study analyzed the gait analysis data of 155 patients (N=155) with hip osteoarthritis who were admitted to a university hospital for total hip replacement and were able to walk on a treadmill without a handrail. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: The dependent variables were gait parameters during treadmill walking. These included gait speed, stride length, cadence, coefficient of variation of stride length and stride time, swing time symmetry index, and step symmetry index. Single and multiple regression analyses were conducted using independent variables of the characteristics and symptoms of the patients, including age, sex, height, pain, leg-length discrepancy, and muscle strength of the affected and normal sides measured with a hand-held dynamometer (iliopsoas, gluteus medius, and quadriceps). RESULTS: In the analysis, gait speed and stride were the dependent variables, whereas age, height, and muscle strength on the affected side were the significant independent variables (P<.05). Additionally, pain demonstrated a marginal association with gait speed (P=.053). Only the leg-length discrepancy correlated with cadence. When the coefficient of variation of the stride length was the dependent variable, age and muscle strength on the affected side were significant. For the swing time symmetry index, only the muscle strength on the affected side was significant. Furthermore, the step symmetry index only correlated with leg-length discrepancy. The muscle strength on the affected side was the only significant independent variable for the coefficient of variation of the stride time. CONCLUSIONS: The results revealed that each of the frequent clinical symptoms of hip osteoarthritis, such as pain, muscle weakness, and leg-length discrepancy, can explain different aspects of gait performance.

痙縮の定量的評価機器を用いたボツリヌス治療の効果判定　　　　　　　　　　　　　　　
伊藤 翔太, 谷川 広樹, 寺西 利生, 近藤 輝, 小関 秀宙, 伊藤 俊貴, 藤村 健太, 平野 哲, 向野 雅彦, 加賀谷 斉
日本ボツリヌス治療学会雑誌, 9, 1, 51, 51, 日本ボツリヌス治療学会, 2023年09月
日本語

変形性股関節症患者におけるDuchenne歩行の定量的分析　　　　　　　　　　　　　　　
小桑 隆, 大塚 圭, 向野 雅彦, 土山 和大, 山田 純也, 松田 文浩, 谷川 広樹, 寺西 利生, 大高 洋平
運動器理学療法学, 3, Suppl., O, 97, (一社)日本運動器理学療法学会, 2023年06月
日本語

ICD-11V章を用いた横断的生活機能調査　　　　　　　　　　　　　　　
向野 雅彦, 山田 深, 大夛賀 政昭, 出江 紳一
The Japanese Journal of Rehabilitation Medicine, 60, 特別号, 4, 2, (公社)日本リハビリテーション医学会, 2023年05月
日本語

歩行能力改善遷延例の退院時歩行能力自立予測 hitoeシステムを用いた活動モニタリングに基づく検討　　　　　　　　　　　　　　　
松浦 広昂, 向野 雅彦, 小笠原 隆行, 青嶋 保志, 鈴木 卓弥, 古澤 章太郎, 大高 洋平
The Japanese Journal of Rehabilitation Medicine, 60, 特別号, 3, 1, (公社)日本リハビリテーション医学会, 2023年05月
日本語

歩行能力改善遷延例の退院時歩行能力自立予測 hitoeシステムを用いた活動モニタリングに基づく検討　　　　　　　　　　　　　　　
松浦 広昂, 向野 雅彦, 小笠原 隆行, 青嶋 保志, 鈴木 卓弥, 古澤 章太郎, 大高 洋平
The Japanese Journal of Rehabilitation Medicine, 60, 特別号, 3, 1, (公社)日本リハビリテーション医学会, 2023年05月
日本語

【超高齢者への心臓リハビリテーションの挑戦】心臓リハビリテーションを軸とした高齢心不全患者に対する急性期診療
河野 裕治, 船戸 優佑, 小澤 祐士, 水谷 公司, 千手 佑樹, 向野 雅彦, 簗瀬 正伸, 井澤 英夫, 大高 洋平
心臓リハビリテーション, 29, 1, 33, 36, (NPO)日本心臓リハビリテーション学会, 2023年03月
日本語

A Tablet-Based Aphasia Assessment System "STELA": Feasibility and Validation Study.
Yoko Inamoto, Masahiko Mukaino, Sayuri Imaeda, Manami Sawada, Kumi Satoji, Ayako Nagai, Satoshi Hirano, Hideto Okazaki, Eiichi Saitoh, Shigeru Sonoda, Yohei Otaka
JMIR formative research, 7, e42219, 2023年02月08日, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: There is an extensive library of language tests, each with excellent psychometric properties; however, many of the tests available take considerable administration time, possibly bearing psychological strain on patients. The Short and Tailored Evaluation of Language Ability (STELA) is a simplified, tablet-based language ability assessment system developed to address this issue, with a reduced number of items and automated testing process. OBJECTIVE: The aim of this paper is to assess the administration time, internal consistency, and validity of the STELA. METHODS: The STELA consists of a tablet app, a microphone, and an input keypad for clinician's use. The system is designed to assess language ability with 52 questions grouped into 2 comprehension modalities (auditory comprehension and reading comprehension) and 3 expression modalities (naming and sentence formation, repetition, and reading aloud). Performance in each modality was scored as the correct answer rate (0-100), and overall performance expressed as the sum of modality scores (out of 500 points). RESULTS: The time taken to complete the STELA was significantly less than the time for the WAB (mean 16.2, SD 9.4 vs mean 149.3, SD 64.1 minutes; P<.001). The STELA's total score was strongly correlated with the WAB Aphasia Quotient (r=0.93, P<.001), supporting the former's concurrent validity concerning the WAB, which is a gold-standard aphasia assessment. Strong correlations were also observed at the subscale level; STELA auditory comprehension versus WAB auditory comprehension (r=0.75, P<.001), STELA repetition versus WAB repetition (r=0.96, P<.001), STELA naming and sentence formation versus WAB naming and word finding (r=0.81, P<.001), and the sum of STELA reading comprehension or reading aloud versus WAB reading (r=0.82, P<.001). Cronbach α obtained for each modality was .862 for auditory comprehension, .872 for reading comprehension, .902 for naming and sentence formation, .787 for repetition, and .892 for reading aloud. Global Cronbach α was .961. The average of the values of item-total correlation to each subscale was 0.61 (SD 0.17). CONCLUSIONS: Our study confirmed significant time reduction in the assessment of language ability and provided evidence for good internal consistency and validity of the STELA tablet-based aphasia assessment system.

Effect of the Effortful Swallow on Pharyngeal Cavity Volume: Kinematic Analysis in Three Dimensions Using 320-Row Area Detector Computed Tomography
Yoko Inamoto, Eiichi Saitoh, Keiko Aihara, Yuriko Ito, Hitoshi Kagaya, Seiko Shibata, Masahiko Mukaino, Masanao Kobayashi, Marlis F. Gonzalez
Dysphagia, Springer Science and Business Media LLC, 2023年01月07日
研究論文（学術雑誌）

Ensemble averaging for categorical variables: Validation study of imputing lost data in 24-h recorded postures of inpatients.
Takayuki Ogasawara, Masahiko Mukaino, Hirotaka Matsuura, Yasushi Aoshima, Takuya Suzuki, Hiroyoshi Togo, Hiroshi Nakashima, Eiichi Saitoh, Masumi Yamaguchi, Yohei Otaka, Shingo Tsukada
Frontiers in physiology, 14, 1094946, 1094946, 2023年, ［国際誌］
英語, 研究論文（学術雑誌）, Acceleration sensors are widely used in consumer wearable devices and smartphones. Postures estimated from recorded accelerations are commonly used as features indicating the activities of patients in medical studies. However, recording for over 24 h is more likely to result in data losses than recording for a few hours, especially when consumer-grade wearable devices are used. Here, to impute postures over a period of 24 h, we propose an imputation method that uses ensemble averaging. This method outputs a time series of postures over 24 h with less lost data by calculating the ratios of postures taken at the same time of day during several measurement-session days. Whereas conventional imputation methods are based on approaches with groups of subjects having multiple variables, the proposed method imputes the lost data variables individually and does not require other variables except posture. We validated the method on 306 measurement data from 99 stroke inpatients in a hospital rehabilitation ward. First, to classify postures from acceleration data measured by a wearable sensor placed on the patient's trunk, we preliminary estimated possible thresholds for classifying postures as 'reclining' and 'sitting or standing' by investigating the valleys in the histogram of occurrences of trunk angles during a long-term recording. Next, the imputations of the proposed method were validated. The proposed method significantly reduced the missing data rate from 5.76% to 0.21%, outperforming a conventional method.

Effects of Posterior Spinal Correction and Fusion on Postural Stability in Patients with Adolescent Idiopathic Scoliosis.
Satoshi Osuka, Hideki Sudo, Katsuhisa Yamada, Hiroyuki Tachi, Kentaro Watanabe, Fuma Sentoku, Takeshi Chiba, Norimasa Iwasaki, Masahiko Mukaino, Harukazu Tohyama
Journal of clinical medicine, 12, 1, 2022年12月29日, ［国際誌］
英語, 研究論文（学術雑誌）, The present study aimed to assess the effects of posterior spinal correction and fusion on postural stability in patients with adolescent idiopathic scoliosis (AIS). The study included 41 female patients with AIS at our institution. All patients performed three 10 s single-leg standing trials on a force plate. The center of pressure (COP) was measured preoperatively, and at 1 week and 6 months postoperatively. The postural stability parameters were absolute minimum time-to-boundary (TTB), mean of the minimum TTB, mean COP velocity, standard deviation, range, and 95% confidence ellipse area. One-way repeated analysis of variance or Friedman test was applied to the postural stability parameters. Multiple comparisons were performed using the Bonferroni correction. The absolute minimum TTB and the mean minimum TTB showed a significant increase 6 months post-operation as compared to preoperatively and 1 week postoperatively. The COP velocity significantly decreased at 6 months post-operation compared to preoperatively and 1 week postoperatively. These changes in postural stability indicate that spinal correction and fusion can be considered to improve postural stability during single-leg standing tests in the postoperative period.

Characterization of Postural Control in Post-Stroke Patients by Musculoskeletal Simulation
Kohei Kaminishi, Dongdong Li, Ryosuke Chiba, Kaoru Takakusaki, Masahiko Mukaino, Jun Ota
Journal of Robotics and Mechatronics, 34, 6, 1451, 1462, Fuji Technology Press Ltd., 2022年12月20日
研究論文（学術雑誌）, An association is observed between the standing sway posture and falls in patients with stroke; hence, it is important to study their standing balance. Although there are studies on the standing balance in stroke patients, differences in control have not been adequately investigated. This study aims to propose a method to characterize the postural sway in standing stroke patients using a mathematical model. A musculoskeletal model and neural controller model were used to simulate ten stroke patients (five patients with cerebral hemorrhages and five patients with cerebral infarctions) and eight young healthy participants, and their data were monitored during quiet standing. The model parameters were adjusted by focusing on the maximum-minimum difference in sway, which was considered important in a previous study, and sway speed, which is frequently used in the analysis. The adjusted model parameters were subjected to dimension reduction using non-negative matrix factorization. Consequently, the sway characteristics of stroke patients were expressed as the magnitude of gain parameters related to the extension of the entire body. The results of this study demonstrated the possibility of representing the characteristics of postural sway as model parameters in stroke patients using a mathematical model. This characterization could lead to the design of individualized rehabilitation systems in the future.

Validity of trunk acceleration measurement with a chest-worn monitor for assessment of physical activity intensity
Masahiko Mukaino, Takayuki Ogasawara, Hirotaka Matsuura, Yasushi Aoshima, Takuya Suzuki, Shotaro Furuzawa, Masumi Yamaguchi, Hiroshi Nakashima, Eiichi Saitoh, Shingo Tsukada, Yohei Otaka
BMC Sports Science, Medicine and Rehabilitation, 14, 1, Springer Science and Business Media LLC, 2022年12月
研究論文（学術雑誌）, Abstract

Background

Recent advancements in wearable technology have enabled easy measurement of daily activities, potentially applicable in rehabilitation practice for various purposes such as maintaining and increasing patients’ activity levels. In this study, we aimed to examine the validity of trunk acceleration measurement using a chest monitor embedded in a smart clothing system (‘hitoe’ system), an emerging wearable system, in assessing the physical activity in an experimental setting with healthy subjects (Study 1) and in a clinical setting with post-stroke patients (Study 2).

Methods

Study 1 involved the participation of 14 healthy individuals. The trunk acceleration, heart rate (HR), and oxygen consumption were simultaneously measured during treadmill testing with a Bruce protocol. Trunk acceleration and HR were measured using the "hitoe" system, a smart clothing system with embedded chest sensors. Expiratory gas analysis was performed to measure oxygen consumption. Three parameters, moving average (MA), moving standard deviation (MSD), and moving root mean square (RMS), were calculated from the norm of the trunk acceleration. The relationships between these accelerometer-based parameters and oxygen consumption-based physical activity intensity measured with the percent VO2 reserve (%VO₂R) were examined. In Study 2, 48 h of simultaneous measurement of trunk acceleration and heart rate-based physical activity intensity in terms of percent heart rate reserve (%HRR) was conducted with the "hitoe" system in 136 post-stroke patients.

Results

The values of MA, MSD, RMS, and %VO₂R were significantly different between levels 1, 2, 3, and 4 in the Bruce protocol (P < 0.01). The average coefficients of determination for individual regression for %VO₂R versus MA, %VO₂R versus MSD, and %VO₂R versus RMS were 0.89 ± 0.05, 0.96 ± 0.03, and 0.91 ± 0.05, respectively. Among the parameters examined, MSD showed the best correlation with %VO₂R, indicating high validity of the parameter for assessing physical activity intensity. The 48-h measurement of MSD and %HRR in post-stroke patients showed significant within-individual correlation (P < 0.05) in 131 out of 136 patients (correlation coefficient: 0.60 ± 0.16).

Conclusions

The results support the validity of the MSD calculated from the trunk acceleration measured with a smart clothing system in assessing the physical activity intensity.

Trial registration: UMIN000034967. Registered 21 November 2018 (retrospectively registered).

Rehabilitation outcomes in patients with lower limb amputation receiving haemodialysis: A retrospective cohort study
Yoshitaka Wada, Yohei Otaka, Yuki Senju, Hiroshi Hosokawa, Takamichi Tohyama, Hirofumi Maeda, Masahiko Mukaino, Seiko Shibata, Satoshi Hirano
Journal of Rehabilitation Medicine - Clinical Communications, 5, jrmcc00088, jrmcc00088, Medical Journals Sweden AB, 2022年11月24日
研究論文（学術雑誌）, Objective: To compare the functional outcomes of patients with lower limb amputations receiving haemodialysis and those not receiving haemodialysis.Design: A retrospective cohort study. Patients: Patients with lower limb amputation who were admitted to a convalescent rehabilitation ward between January 2018 and December 2021.Methods: The primary outcome was the effectiveness of the Functional Independence Measure (FIM) during hospitalisation in the ward. Secondary outcomes included the total and subtotal (motor/cognitive) FIM scores at discharge, gain in the total and subtotal (motor/cognitive) FIM scores, K-level at discharge, length of hospital stay in the ward, rehabilitation time, and discharge destination. Outcomes were compared between the non-haemodialysis and haemodialysis groups.Results: A total of 28 patients (mean [standard deviation] age, 67.0 [11.9] years; men, 20) were enrolled in this study. Among them, 11 patients underwent haemodialysis. The FIM effectiveness was significantly higher in the non-haemodialysis group than in the haemodialysis group (median [interquartile range], 0.78 [0.72 – 0.81] vs 0.65 [0.28 – 0.75], p = 0.038). The amount of rehabilitation and all secondary outcomes were not significantly different between the groups (p > 0.05).Conclusion: Patients with lower limb amputation who were receiving haemodialysis had poorer FIM effectiveness than those not receiving haemodialysis.LAY ABSTRACTChronic kidney disease is a risk factor for foot ulcers and lower limb amputation. Thus, patients with lower limb amputation often require maintenance dialysis. However, there is a lack of knowledge on whether patients with lower limb amputation receiving haemodialysis can achieve functional outcomes comparable to those not receiving haemodialysis. This study aimed to compare functional outcomes between patients with lower limb amputations receiving haemodialysis and those not receiving haemodialysis. This retrospective cohort study enrolled 28 patients who underwent amputation surgery and were admitted to a rehabilitation ward, including 11 patients undergoing haemodialysis (8 with diabetic nephropathy, 1 with chronic glomerulonephritis, 1 with rapidly progressive glomerulonephritis, and 1 with acute kidney injury). Although the amount of rehabilitation did not differ between groups, the improvement in the activities of daily living was significantly better in the non-haemodialysis group than in the haemodialysis group. Thus, even the same amount of rehabilitation for patients with lower limb amputations receiving haemodialysis may not lead to functional outcomes comparable to those without haemodialysis.

Reliability and validity of the public transportation use assessment form for individuals after stroke
Shin Kitamura, Yohei Otaka, Kazuki Ushizawa, Seigo Inoue, Sachiko Sakata, Kunitsugu Kondo, Masahiko Mukaino, Eiji Shimizu
Disability and Rehabilitation, 45, 14, 1, 8, Informa UK Limited, 2022年10月14日
研究論文（学術雑誌）

Development of a simple mechanical measurement method to measure spasticity based on an analysis of a clinical maneuver and its concurrent validity with the modified Ashworth scale
Hiroki Tanikawa, Masahiko Mukaino, Shota Itoh, Hikaru Kondoh, Kenta Fujimura, Toshio Teranishi, Kei Ohtsuka, Satoshi Hirano, Hitoshi Kagaya, Eiichi Saitoh, Yohei Otaka
Frontiers in Bioengineering and Biotechnology, 10, Frontiers Media SA, 2022年08月15日
研究論文（学術雑誌）, Background: Despite recent developments in the methodology for measuring spasticity, the discriminative capacity of clinically diagnosed spasticity has not been well established. This study aimed to develop a simple device for measuring velocity-dependent spasticity with improved discriminative capacity based on an analysis of clinical maneuver and to examine its reliability and validity.

Methods: This study consisted of three experiments. First, to determine the appropriate motion of a mechanical device for the measurement of velocity-dependent spasticity, the movement pattern and the angular velocity used by clinicians to evaluate velocity-dependent spasticity were investigated. Analysis of the procedures performed by six physical therapists to evaluate spasticity were conducted using an electrogoniometer. Second, a device for measuring the resistance force against ankle dorsiflexion was developed based on the results of the first experiment. Additionally, preliminary testing of validity, as compared to that of the Modified Ashworth Scale (MAS), was conducted on 17 healthy participants and 10 patients who had stroke with spasticity. Third, the reliability of the measurement and the concurrent validity of mechanical measurement in the best ankle velocity setting were further tested in a larger sample comprising 24 healthy participants and 32 patients with stroke.

Results: The average angular velocity used by physical therapists to assess spasticity was 268 ± 77°/s. A device that enabled the measurement of resistance force at velocities of 300°/s, 150°/s, 100°/s, and 5°/s was developed. In the measurement, an angular velocity of 300°/s was found to best distinguish patients with spasticity (MAS of 1+ and 2) from healthy individuals. A measurement of 300°/s in the larger sample differentiated the control group from the MAS 1, 1+, and 2 subgroups (p &lt; 0.01), as well as the MAS 1 and 2 subgroups (p &lt; 0.05). No fixed or proportional bias was observed in repeated measurements.

Conclusion: A simple mechanical measurement methodology was developed based on the analysis of the clinical maneuver for measuring spasticity and was shown to be valid in differentiating the existence and extent of spasticity. This study suggest possible requirements to improve the quality of the mechanical measurement of spasticity.

Development of an assessment form for the performance of public transportation use in individuals with stroke.
Kazuki Ushizawa, Yohei Otaka, Shin Kitamura, Seigo Inoue, Sachiko Sakata, Kunitsugu Kondo, Masahiko Mukaino, Eiji Shimizu
Disability and rehabilitation, 1, 10, 2022年06月28日, ［国際誌］
英語, 研究論文（学術雑誌）, PURPOSE: To develop a new assessment form that is assessed by therapists for the performance of public transportation use for stroke survivors through content validation. MATERIALS AND METHODS: The items for the tentative assessment form were selected using hierarchical clustering analysis on previous records of 76 field-based training sessions for public transportation use for stroke survivors. After the modification of the tentative form based on 6 months of clinical use, the final form was developed through content validation using the Delphi method by 71 therapists who had been working at the hospital for more than 2 years and had experience with training for public transportation use. RESULTS: The Public Transportation use Assessment Form (PTAF) for stroke was successfully developed through three validation processes. It consists of four categories (plan for going out, mobility, using trains, and using buses) including 15 items that cover various tasks of public transportation use. The scoring for each was as follows: 3, independent; 2, requires supervision of verbal assistance; 1, requires assistance; and N, not applicable. CONCLUSION: The PTAF, developed through content validation, could assess the ability of public transportation use, and identify specific problems for each stroke survivor in clinical setting.IMPLICATIONS FOR REHABILITATIONWe developed the Public Transportation use Assessment Form (PTAF) to assess the ability of stroke survivors to use public transportation.The PTAF could identify specific problems related to public transportation use for stroke survivors and aid in planning rehabilitation programs based on the results.The PTAF could share information about which task need support in public transportation use and could augment the hospital discharge plan.

簡易的リアルタイム歩行分析システムの信頼性　　　　　　　　　　　　　　　
稲森 遥, 大塚 圭, 向野 雅彦, 山田 純也, 林 弘規, 松田 文浩, 谷川 広樹, 土山 和大, 村上 涼, 才藤 栄一, 大高 洋平
The Japanese Journal of Rehabilitation Medicine, 59, 特別号, S110, S110, (公社)日本リハビリテーション医学会, 2022年05月
日本語

日中離床時間は経カテーテル大動脈弁埋め込み術患者の入院関連身体機能低下の関連因子となる
河野 裕治, 小澤 祐士, 水谷 公司, 千手 佑樹, 船戸 優佑, 向野 雅彦, 村松 崇, 簗瀬 正伸, 井澤 英夫, 大高 洋平
日本循環器病予防学会誌, 57, 2, 132, 132, (一社)日本循環器病予防学会, 2022年05月
日本語

脳卒中患者における日常の活動量に影響を与える因子の検討　　　　　　　　　　　　　　　
和田 義敬, 向野 雅彦, 小笠原 隆行, 鈴木 卓弥, 青嶋 保志, 古澤 章太郎, 松田 文浩, 大高 洋平, 才藤 栄一
The Japanese Journal of Rehabilitation Medicine, 特別号, S439, S439, (公社)日本リハビリテーション医学会, 2022年05月
日本語

簡易的リアルタイム歩行分析システムの信頼性　　　　　　　　　　　　　　　
稲森 遥, 大塚 圭, 向野 雅彦, 山田 純也, 林 弘規, 松田 文浩, 谷川 広樹, 土山 和大, 村上 涼, 才藤 栄一, 大高 洋平
The Japanese Journal of Rehabilitation Medicine, 特別号, S110, S110, (公社)日本リハビリテーション医学会, 2022年05月
日本語

Functional outcomes in acute care settings vary by disease categories but show a consistent pattern of disability.
Koji Mizutani, Yohei Otaka, Masaki Kato, Miwako Hayakawa, Megumi Ozeki, Hirofumi Maeda, Satoshi Hirano, Masahiko Mukaino, Seiko Shibata, Hitoshi Kagaya, Hiroaki Sakurai, Eiichi Saitoh
Annals of physical and rehabilitation medicine, 101648, 101648, 2022年02月24日, ［国際誌］
英語

Thin Liquid Bolus Volume Alters Pharyngeal Swallowing: Kinematic Analysis Using 3D Dynamic CT.
Kannit Pongpipatpaiboon, Yoko Inamoto, Keiko Aihara, Hitoshi Kagaya, Seiko Shibata, Masahiko Mukaino, Eiichi Saitoh, Marlis Gonzalez-Fernandez
Dysphagia, 2022年01月03日, ［国際誌］
英語, 研究論文（学術雑誌）, The previous studies reported that different volumes of thick liquid had an impact on spatiotemporal characteristics and pharyngeal response of swallowing. However, the bolus flow and swallowing motion pattern were different between thick and thin liquids. The effects of thin bolus volume on pharyngeal swallowing, especially true vocal cord (TVC) closure is still unclear. This study assessed the temporal characteristics when swallowing different volumes of thin liquid to determine the mechanical adaptation using 320-row area detector computed tomography (320-ADCT) and investigated a change of swallowing physiology including laryngeal closure, particularly TVC closure. Fourteen healthy women (28-45 years) underwent 320-ADCT while swallowing of 3, 10, and 20 ml of thin liquid barium in 45° semi-reclining position. Kinematic analysis was performed for each swallow including temporal characteristic, structural movements while swallowing, and maximal cross-sectional area of the upper esophageal sphincter (UES) opening. Bolus head reached to pharynx and esophagus earlier in larger volume significantly, indicating faster bolus transport as volume increased. There were significant effects on swallowing mechanism revealing earlier TVC closure and UES opening with increasing volume. Maximum cross-sectional area of the UES opening was increased to accommodate a larger bolus. Differences in mechanical adaptation through bolus transit and motion of swallowing structures were detected across increasing volumes. These volume-dependent adaptations potentially reduce the risk of aspiration. Understanding the swallowing physiological changes as volume increased is helpful for diagnosis and treatment of dysphagia patients as well as outcomes of swallowing rehabilitation in clinical practice.

A novel gait analysis system for detecting abnormal hemiparetic gait patterns during robot-assisted gait training: A criterion validity study among healthy adults.
Daisuke Imoto, Satoshi Hirano, Masahiko Mukaino, Eiichi Saitoh, Yohei Otaka
Frontiers in neurorobotics, 16, 1047376, 1047376, 2022年, ［国際誌］
英語, 研究論文（学術雑誌）, INTRODUCTION: Robot-assisted gait training has been reported to improve gait in individuals with hemiparetic stroke. Ideally, the gait training program should be customized based on individuals' gait characteristics and longitudinal changes. However, a gait robot that uses gait characteristics to provide individually tailored gait training has not been proposed. The new gait training robot, "Welwalk WW-2000," permits modification of various parameters, such as time and load of mechanical assistance for a patient's paralyzed leg. The robot is equipped with sensors and a markerless motion capture system to detect abnormal hemiparetic gait patterns during robot-assisted gait training. Thus, it can provide individually tailored gait training. This study aimed to investigate the criterion validity of the gait analysis system in the Welwalk WW-2000 in healthy adults. MATERIALS AND METHODS: Twelve healthy participants simulated nine abnormal gait patterns that were often manifested in individuals with hemiparetic stroke while wearing the robot. Each participant was instructed to perform a total of 36 gait trials, with four levels of severity for each abnormal gait pattern. Fifteen strides for each gait trial were recorded using the markerless motion capture system in the Welwalk WW-2000 and a marker-based three-dimensional (3D) motion analysis system. The abnormal gait pattern index was then calculated for each stride from both systems. The correlation of the index values between the two methods was evaluated using Spearman's rank correlation coefficients for each gait pattern in each participant. RESULTS: Using the participants' index values for each abnormal gait pattern obtained using the two motion analysis methods, the median Spearman's rank correlation coefficients ranged from 0.68 to 0.93, which corresponded to moderate to very high correlation. CONCLUSION: The gait analysis system in the Welwalk WW-2000 for real-time detection of abnormal gait patterns during robot-assisted gait training was suggested to be a valid method for assessing gait characteristics in individuals with hemiparetic stroke. CLINICAL TRIAL REGISTRATION: [https://jrct.niph.go.jp], identifier [jRCT 042190109].

Development and preliminary evaluation of a tele-rehabilitation exercise system using computer-generated animation
Kumazawa Nobuhiro, Koyama Soichiro, Mukaino Masahiko, Tsuchiyama Kazuhiro, Tatemoto Tsuyoshi, Tanikawa Hiroki, Ohtsuka Kei, Katoh Masaki, Otaka Yohei, Saitoh Eiichi, Tanabe Shigeo
Fujita Medical Journal, advpub, Fujita Medical Society, 2022年
英語, Objectives: To evaluate the safety and acceptability of a newly developed tele-rehabilitation exercise system using computer-generated animation.

Methods: The participants comprised a convenience sample of 38 diverse individuals in Experiment 1 (15 healthy young people, 16 healthy older people, 5 patients with stroke, and 2 patients with respiratory disease) and 18 healthy older individuals in Experiment 2. Experiment 1 assessed safety in terms of cardiopulmonary vascular aspects and risk of fall, and Experiment 2 assessed treatment acceptability via a subjective evaluation. All participants completed the same exercise program. The safety assessment was conducted using heart rate (HR) and saturation of percutaneous oxygen (SpO2), measured before and after exercise. In addition, the occurrence of falls was assessed. For the acceptability assessment, the participants answered five questions (three-point Likert scale) after the exercise program.

Results: The safety assessment indicated that HR and SpO2 changed from 70.5±10.2 beats per minute and 97.8±1.3% before exercise to 87.6±13.6 beats per minute and 98.2±0.9% after exercise, respectively. In addition, all participants completed the exercises without experiencing any falls. In the acceptability assessment, the score reflecting continuation desire was the highest of the five items examined (2.71±0.46). In contrast, the adequacy of exercise intensity had the lowest score (1.29±0.57).

Conclusions: The present system was confirmed to be safe, and the participants were motivated to continue the exercises. Future developments should incorporate a function to enable participants and medical staff to adjust exercise intensity according to individual physical function.

Requirements for Eliciting a Spastic Response With Passive Joint Movements and the Influence of Velocity on Response Patterns: An Experimental Study of Velocity-Response Relationships in Mild Spasticity With Repeated-Measures Analysis.
Kenta Fujimura, Masahiko Mukaino, Shota Itoh, Haruna Miwa, Ryoka Itoh, Daisuke Narukawa, Hiroki Tanikawa, Yoshikiyo Kanada, Eiichi Saitoh, Yohei Otaka
Frontiers in neurology, 13, 854125, 854125, 2022年, ［国際誌］
英語, 研究論文（学術雑誌）, Background: Spasticity is defined as a velocity-dependent increase in tonic stretch reflexes and is manually assessed in clinical practice. However, the best method for the clinical assessment of spasticity has not been objectively described. This study analyzed the clinical procedure to assess spasticity of the elbow joint using an electrogoniometer and investigated the appropriate velocity required to elicit a spastic response and the influence of velocity on the kinematic response pattern. Methods: This study included eight healthy individuals and 15 patients with spasticity who scored 1 or 1+ on the modified Ashworth Scale (MAS). Examiners were instructed to manually assess spasticity twice at two different velocities (slow and fast velocity conditions). During the assessment, velocity, deceleration value, and angle [described as the % range of motion (%ROM)] at the moment of resistance were measured using an electrogoniometer. Differences between the slow and fast conditions were evaluated. In addition, variations among the fast condition such as the responses against passive elbow extension at <200, 200-300, 300-400, 400°/s velocities were compared between the MAS 1+, MAS 1, and control groups. Results: Significant differences were observed in the angular deceleration value and %ROM in the fast velocity condition (417 ± 80°/s) between patients and healthy individuals, but there was no difference in the slow velocity condition (103 ± 29°/s). In addition, the deceleration values were significantly different between the MAS 1 and MAS 1+ groups in velocity conditions faster than 300°/s. In contrast, the value of %ROM plateaued when the velocity was faster than 200°/s. Conclusion: The velocity of the passive motion had a significant effect on the response pattern of the elbow joint. The velocity-response pattern differed between deceleration and the angle at which the catch occurred; the value of deceleration value for passive motion was highly dependent on the velocity, while the %ROM was relatively stable above a certain velocity threshold. These results provide clues for accurate assessment of spasticity in clinical practice.

Stroke Patients with Nearly Independent Transfer Ability are at High Risk of Falling.
Yoshitaka Kato, Shin Kitamura, Masaki Katoh, Asuka Hirano, Yuki Senjyu, Mao Ogawa, Hirofumi Maeda, Masahiko Mukaino, Satoshi Hirano, Hiroaki Sakurai, Seiko Shibata, Yohei Otaka
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 31, 1, 106169, 106169, 2022年01月, ［国際誌］
英語, 研究論文（学術雑誌）, OBJECTIVES: To examine the relationship between patients' transfer ability and fall risk in stroke patients during hospitalization. MATERIALS AND METHODS: We retrospectively enrolled 237 stroke patients who were transferred to a convalescent rehabilitation ward from acute wards in the same hospital. Using incident reports, we investigated their fall rates and activity status at the falls according to their transfer abilities, which were assessed with Functional Independence Measure (FIM) transfer scores. The bi-weekly time trend of fall rates in all patients and in three subgroups based on FIM transfer scores of 1-3, 4-5, and 6-7, and activity status at the falls, were investigated. In addition, changes of patients' transfer ability on admission, at the first fall, and at discharge were investigated among falling patients. RESULTS: The fall rate was the greatest in patients with a FIM transfer score of 4 (14.3 times/1000 person-days). The majority of falls for patients with a FIM transfer score of 1 occurred at the activity status of "on the bed" and "sitting", while three quarters of patients with a FIM score of 7 had falls during "standing" and "walking". No longitudinal trend in fall rates was found overall; however, the fall rate trends differed depending on the FIM transfer score. The majority of the patients who fell required full assistance for transfers upon admission but required no assistance at discharge. CONCLUSIONS: Fall risk differed among patients with various transfer abilities; the greatest risk was in those who needed minimal assistance for transfers.

Overcoming language barriers to provide telerehabilitation for COVID-19 patients: a two-case report.
Tsuyoshi Tatemoto, Masahiko Mukaino, Nobuhiro Kumazawa, Shigeo Tanabe, Koji Mizutani, Masaki Katoh, Eiichi Saitoh, Yohei Otaka
Disability and rehabilitation. Assistive technology, 1, 8, 2021年12月27日, ［国際誌］
英語, 研究論文（学術雑誌）, PURPOSE: This report presents two cases of successful telerehabilitation delivery for patients quarantined due to COVID-19. One of the patients did not speak the therapists' language, whereas the other presented complete deafness. MATERIALS AND METHODS: We assembled a telerehabilitation system using commercial applications, including a remote-control application that minimizes the need for patient's input. The telerehabilitation comprised a combination of video calls with a physical therapist and a 20-minute exercise video. The first case was of a 72-year-old man who could only speak Cantonese, a language that none of the service providers could speak, making communication difficult. Therefore, telerehabilitation was provided using Google Translate to simultaneously translate the therapist's instructions in Japanese to Cantonese. The second case involved a 49-year-old man with neurofibromatosis and complete deafness. In this case, communication during the exercise programme was achieved using 25 cue cards that were prepared in advance and used to convey instructions. The patients' satisfaction was assessed using either of a simple three-item questionnaire (Case 1) or the Telemedicine Satisfaction Questionnaire with five additional items (Case 2). RESULTS: In both cases, the exercise programme was successfully conducted, and the patients reported being highly satisfied with the programme. CONCLUSIONS: Communication barriers can impede telerehabilitation therapy; this problem is aggravated when the recipients cannot receive on-site education for device operation and exercise performance in advance due to COVID-19 restrictions. However, the use of supplementary methodologies may contribute to solving these issues, further expanding the coverage and applicability of telerehabilitation.IMPLICATIONS FOR REHABILITATIONWe provided telerehabilitation for two patients with communication difficulties who were quarantined due to COVID-19.Telerehabilitation was carried out using a system with a remote-control mechanism to minimise patient input and avoid problems caused by their unfamiliarity in operating the devices.In addition, an online translation mechanism was used to overcome language differences, while cue cards were used for a patient with a hearing impairment.Telerehabilitation was performed without any technical issues. Both patients reported being highly satisfied with the intervention.This experience of providing telerehabilitation and overcoming communication difficulties may help develop a strategy to expand the coverage of telerehabilitation in the treatment of patients in isolation due to highly transmissible diseases, such as COVID-19.

ICFに基づく生活機能評価の臨床導入に向けて　　　　　　　　　　　　　　　
向野 雅彦, 山田 深, 出江 紳一
医療情報学連合大会論文集, 41回, 252, 254, (一社)日本医療情報学会, 2021年11月
日本語

高齢心不全患者における経カテーテル大動脈弁置換術前後の身体機能の推移に関する実態調査(第1報)　　　　　　　　　　　　　　　
小澤 祐士, 河野 裕治, 水谷 公司, 千手 佑樹, 前田 寛文, 向野 雅彦, 大高 洋平
The Japanese Journal of Rehabilitation Medicine, 58, 秋季特別号, S455, S455, (公社)日本リハビリテーション医学会, 2021年10月
日本語

脳卒中患者に対する上肢ロボット練習が上肢・体幹運動へ与える影響 動作分析を用いて予備的検討をした1例　　　　　　　　　　　　　　　
太田 皓文, 向野 雅彦, 井上 由加里, 才藤 栄一, 大高 洋平
The Japanese Journal of Rehabilitation Medicine, 58, 秋季特別号, S461, S461, (公社)日本リハビリテーション医学会, 2021年10月
日本語

回復期リハ病棟入院患者の24時間活動モニタリングに基づく消費エネルギーの推定と体重推移の比較　　　　　　　　　　　　　　　
新家 翼, 向野 雅彦, 三鬼 達人, 稲垣 喜信, 松田 文浩, 青嶋 保志, 鈴木 卓弥, 小笠原 隆行, 大高 洋平, 才藤 栄一
学会誌JSPEN, 3, Suppl.1, 680, 680, (一社)日本臨床栄養代謝学会, 2021年10月
日本語

Effects of ankle-foot orthoses on the stability of post-stroke hemiparetic gait.
Kazuhiro Tsuchiyama, Masahiko Mukaino, Kei Ohtsuka, Fumihiro Matsuda, Hiroki Tanikawa, Junya Yamada, Kannit Pongpipatpaiboon, Yoshikiyo Kanada, Eiichi Saitoh, Yohei Otaka
European journal of physical and rehabilitation medicine, 2021年09月09日, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: Ankle-foot orthoses are used to improve gait stability in patients with post-stroke gait; however, there is not enough evidence to support their beneficial impact on gait stability. AIM: To investigate the effects of ankle-foot orthoses on post-stroke gait stability. DESIGN: An experimental study with repeated measurements of gait parameters with and without orthosis. SETTING: Inpatients and outpatients in the Fujita Health University Hospital. POPULATION: Thirty-two patients (22 males; mean age 48.3±20.0 years) with poststroke hemiparesis participated in the study. METHODS: Three-dimensional treadmill gait analysis was performed with and without ankle-foot orthosis for each participant. Spatiotemporal parameters, their coefficient of variation, and margin of stability were evaluated. Toe clearance, another major target of orthosis, was also examined. The effect of orthosis in the patients with severe (not able to move within the full range of motion, defying gravity) and mild ankle impairment (able to move within the full range but have problem with speed and/or smoothness of the ankle movement) was compared. RESULTS: In the total group comparison, the decrease in the coefficient of variation of step width (P=0.012), and margin of stability on the paretic side (P=0.023) were observed. In the severe ankle impairment groups, the decreased in the coefficient of variation of the non-paretic step length (P=0.007), stride length (P=0.037), and step width (P=0.033) and margin of stability on the paretic side (P=0.006) were observed. No significant effects were observed in the mild ankle impairment group; rather, the coefficient of variation of non-paretic step length increased with the use of orthosis in this group (P=0.043); however, toe clearance increased with the use of ankle-foot orthosis (P=0.041). CONCLUSIONS: Ankle-foot orthoses improved gait stability indices; however, the effect was either not significant or showed possible worsening in the patients with mild ankle impairment, while the effect on toe clearance was significant. These results suggest that the effects of using orthoses in patients with mild impairment should be carefully evaluated. CLINICAL REHABILITATION IMPACT: Understanding the effects of ankle-foot orthoses on the stability of post-stroke gait and their relationship with ankle impairment severity may support clinical decision-making while prescribing orthosis for post-stroke hemiparesis.

Outcomes of Dysphagia Following Stroke: Factors Influencing Oral Intake at 6 Months After Onset.
Sachiyo Hota, Yoko Inamoto, Kazuyo Oguchi, Tomoko Kondo, Eri Otaka, Masahiko Mukaino, Marlis Gonzalez-Fernandez, Eiichi Saitoh
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 30, 9, 105971, 105971, 2021年09月, ［国際誌］
英語, 研究論文（学術雑誌）, PURPOSE: This study aimed to describe recovery of dysphagia after stroke. We determined the proportion of stroke survivors with dysphagia on admission, discharge, and 6 months after stroke. Additionally, the factors affecting oral feeding 6 months after stroke were explored. METHODS: A total of 427 acute stroke patients were recruited prospectively. Presence of dysphagia was evaluated on admission, weekly until recovery was achieved, and at discharge. We compared stroke survivors with dysphagia who had complete recovery, who had dysphagia but achieved oral feeding, and who required tube feeding. Patient-reported eating ability was evaluated at 6 months. Patients who achieved oral feeding by 6 months were compared to those who had persistent tube feeding need. RESULTS: Fifty-five percent of stroke survivors had dysphagia on initial evaluation (3.1 ± 1.4 days after admission) and 37% at discharge (21.1 ± 12.4 days). At 6 months, 5% of patients required tube feeding. Among those who had dysphagia at initial evaluation, 32% had resolution of dysphagia within two weeks, 44% had dysphagia but started oral feeding before discharge, and 23% required alternative means of alimentation (nasogastric tube feeding, percutaneous endoscopic gastrostomy, parental nutrition) throughout hospitalization. At 6 months, 90% of stroke survivors who achieved oral feeding by discharge continued with oral feeding. Patients who achieved oral feeding after discharge had less cognitive impairments on admission and a higher speech therapist intervention rate after discharge. CONCLUSIONS: More than half of stroke survivors had dysphagia but the vast majority were able to return to oral feeding by 6 months. Cognitive function and dysphagia rehabilitation interventions were associated with return to oral feeding after hospital discharge.

外傷性転倒を経験した脳卒中片麻痺患者の重心の動きのばらつきの特徴
土山 和大, 向野 雅彦, 山田 純也, 大高 洋平
日本転倒予防学会誌, 8, 2, 138, 138, 日本転倒予防学会, 2021年09月
日本語

脳卒中片麻痺者の歩行練習における転倒要因の検討
加藤 洋平, 大塚 圭, 松田 文浩, 山田 純也, 谷川 広樹, 土山 和大, 本間 友己, 加藤 正樹, 向野 雅彦, 才藤 栄一, 大高 洋平
日本転倒予防学会誌, 8, 2, 139, 139, 日本転倒予防学会, 2021年09月
日本語

外傷性転倒を経験した脳卒中片麻痺患者の重心の動きのばらつきの特徴
土山 和大, 向野 雅彦, 山田 純也, 大高 洋平
日本転倒予防学会誌, 8, 2, 138, 138, 日本転倒予防学会, 2021年09月
日本語

脳卒中片麻痺者の歩行練習における転倒要因の検討
加藤 洋平, 大塚 圭, 松田 文浩, 山田 純也, 谷川 広樹, 土山 和大, 本間 友己, 加藤 正樹, 向野 雅彦, 才藤 栄一, 大高 洋平
日本転倒予防学会誌, 8, 2, 139, 139, 日本転倒予防学会, 2021年09月
日本語

The effect of ankle-foot orthosis on ankle kinematics in individuals after stroke: A systematic review and meta-analysis.
Yoshitaka Wada, Yohei Otaka, Masahiko Mukaino, Yasushi Tsujimoto, Akihiro Shiroshita, Nobuyuki Kawate, Shunsuke Taito
PM & R : the journal of injury, function, and rehabilitation, 2021年08月09日, ［国際誌］
英語, 研究論文（学術雑誌）, OBJECTIVE: To evaluate whether ankle-foot orthosis (AFO) has a beneficial effect on dorsiflexion angle increase during the swing phase among individuals with stroke and patient-important outcomes in individuals with stroke. LITERATURE SURVEY: Randomized controlled trials (RCTs), randomized crossover trials, and cluster RCTs until May 2020 were researched through CENTRAL, MEDLINE, EMBASE, PEDro, CINAHL, and REHABDATA databases. Studies reporting on AFO use to improve walking, functional mobility, quality of life, and activity limitations and reports of adverse events in individuals with stroke were included. METHODOLOGY: Two independent reviewers extracted the data and assessed the risk of bias. The certainty of evidence was assessed using the Grading of Recommendations, Assessment, Development and Evaluations approach. SYNTHESIS: Fourteen trials that enrolled 282 individuals with stroke and compared AFO with no AFO were included. Compared with no AFO, AFO could increase the dorsiflexion angle of ankle joints during walking (mean difference [MD, 3.7°]; 95% confidence interval [CI], 2.0-5.3; low certainty of evidence). Furthermore, AFO could improve walking ability (walking speed) (MD, 0.09 [m/s]; 95% CI, 0.06-0.12; low certainty of evidence). No study had reported the effects of AFO on quality of life, adverse events, fall frequency, and activities of daily life. CONCLUSIONS: Our findings suggest that AFO improved ankle kinematics and walking ability in the short term; nonetheless, the evidence was characterized by a low degree of certainty.

Development of a clinical tool for rating the body function categories of the ICF generic-30/rehabilitation set in Japanese rehabilitation practice and examination of its interrater reliability.
Yuki Senju, Masahiko Mukaino, Birgit Prodinger, Melissa Selb, Yuki Okouchi, Kouji Mizutani, Megumi Suzuki, Shin Yamada, Shin-Ichi Izumi, Shigeru Sonoda, Yohei Otaka, Eiichi Saitoh, Gerold Stucki
BMC medical research methodology, 21, 1, 121, 121, 2021年06月14日, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: The International Classification of Functioning, Disability, and Health (ICF) Generic-30 (Rehabilitation) Set is a tool used to assess the functioning of a clinical population in rehabilitation. The ICF Generic-30 consists of nine ICF categories from the component "body functions" and 21 from the component "activities and participation". This study aimed to develop a rating reference guide for the nine body function categories of the ICF Generic-30 Set using a predefined, structured process and to examine the interrater reliability of the ratings using the rating reference guide. METHODS: The development of the first version of the rating reference guide involved the following steps: (1) a trial of rating patients by several raters; (2) cognitive interviews with each rater to analyze the thought process involved in each rating; (3) the drafting of the rating reference guide by a multidisciplinary panel; and (4) a review by ICF specialists to confirm consistency with the ICF. Subsequently, we conducted a first field test to gain insight into the use of the guide in practice. The reference guide was modified based on the raters' feedback in the field test, and an inter-rater reliability test was conducted thereafter. Interrater agreement was evaluated using weighted kappa statistics with linear weights. RESULTS: The first version of the rating reference guide was successfully developed and tested. The weighted kappa coefficient in the field testing ranged from 0.25 to 0.92. The interrater reliability testing of the rating reference guide modified based on the field test results yielded an improved weighted kappa coefficient ranging from 0.53 to 0.78. Relative improvements in the weighted kappa coefficients were observed in seven out of the nine categories. Consequently, seven out of nine categories were found to have a weighted kappa coefficient of 0.61 or higher. CONCLUSIONS: In this study, we developed and modified a rating reference guide for the body function categories of the ICF Generic-30 Set. The interrater reliability test using the final version of the rating reference guide showed moderate to substantial interrater agreement, which encouraged the use of the ICF in rehabilitation practice.

Validation of Data Imputation by Ensemble Averaging to Quantify 24-h Behavior Using Heart Rate of Stroke Rehabilitation Inpatients
Takayuki Ogasawara, Masahiko Mukaino, Yohei Otaka, Hirotaka Matsuura, Yasushi Aoshima, Takuya Suzuki, Hiroyoshi Togo, Hiroshi Nakashima, Masumi Yamaguchi, Shingo Tsukada, Eiichi Saitoh
Journal of Medical and Biological Engineering, 41, 3, 322, 330, Springer Science and Business Media LLC, 2021年06月
研究論文（学術雑誌）

脳卒中後の回復期リハビリテーションにおける活動量の改善 hitoeシステムを用いた検討　　　　　　　　　　　　　　　
水野 江美, 向野 雅彦, 小笠原 隆行, 鈴木 卓弥, 古澤 章太郎, 山田 ゆりえ, 松田 文浩, 松浦 広昴, 才藤 栄一, 大高 洋平
The Japanese Journal of Rehabilitation Medicine, 58, 特別号, 1, 6, (公社)日本リハビリテーション医学会, 2021年05月
日本語

脳卒中患者に対する短下肢装具の足関節背屈の効果 システマティックレビュー・メタアナリシス　　　　　　　　　　　　　　　
和田 義敬, 大高 洋平, 向野 雅彦, 川手 信行
The Japanese Journal of Rehabilitation Medicine, 58, 特別号, 1, 1, (公社)日本リハビリテーション医学会, 2021年05月
日本語

回復期リハビリテーション病棟入院中の状態悪化により死亡に至った症例の検討　　　　　　　　　　　　　　　
前田 寛文, 柴田 斉子, 向野 雅彦, 平野 哲, 大高 洋平
The Japanese Journal of Rehabilitation Medicine, 58, 特別号, 1, 1, (公社)日本リハビリテーション医学会, 2021年05月
日本語

COVID-19肺炎後肺線維症患者に対するリハビリテーション治療に難渋した一例　　　　　　　　　　　　　　　
千手 佑樹, 向野 雅彦, 細川 浩, 木曽 昭史, 前田 寛文, 柴田 斉子, 大高 洋平
The Japanese Journal of Rehabilitation Medicine, 58, 特別号, 2, 6, (公社)日本リハビリテーション医学会, 2021年05月
日本語

回復期脳卒中片麻痺患者における定量的評価機器を用いた痙縮の経時変化 症例報告　　　　　　　　　　　　　　　
近藤 輝, 谷川 広樹, 向野 雅彦, 伊藤 翔太, 加藤 正樹, 寺西 利生, 才藤 栄一, 大高 洋平
The Japanese Journal of Rehabilitation Medicine, 58, 特別号, 1, 6, (公社)日本リハビリテーション医学会, 2021年05月
日本語

hitoe?システムを利用した回復期病棟入院患者の夜間安静時心拍数と1回拍出量の関係　　　　　　　　　　　　　　　
鈴木 卓弥, 向野 雅彦, 山田 ゆりえ, 古澤 章太郎, 犬飼 絢香, 松田 文浩, 松浦 広昂, 小笠原 隆行, 才藤 栄一, 大高 洋平
The Japanese Journal of Rehabilitation Medicine, 58, 特別号, 1, 9, (公社)日本リハビリテーション医学会, 2021年05月
日本語

短下肢装具が片麻痺者の歩行に及ぼす影響 足関節運動機能障害の重症度による違い　　　　　　　　　　　　　　　
土山 和大, 向野 雅彦, 大塚 圭, 松田 文浩, 谷川 広樹, 山田 純也, Kannit Pongpipatpaiboon, 金田 嘉清, 才藤 栄一, 大高 洋平
The Japanese Journal of Rehabilitation Medicine, 58, 特別号, 1, 7, (公社)日本リハビリテーション医学会, 2021年05月
日本語

立位課題による脳卒中片麻痺者の麻痺側下肢機能の定量的評価　　　　　　　　　　　　　　　
松田 文浩, 向野 雅彦, 加藤 洋平, 山田 純也, 大塚 圭, 才藤 栄一, 大高 洋平
The Japanese Journal of Rehabilitation Medicine, 58, 特別号, 1, 4, (公社)日本リハビリテーション医学会, 2021年05月
日本語

hitoeシステムを利用した入院患者の活動量と自立度の関係性　　　　　　　　　　　　　　　
古澤 章太郎, 向野 雅彦, 小笠原 隆行, 鈴木 卓弥, 犬飼 絢香, 山田 ゆりえ, 松田 文浩, 加藤 正樹, 松浦 広昴, 才藤 栄一, 大高 洋平
The Japanese Journal of Rehabilitation Medicine, 58, 特別号, 1, 10, (公社)日本リハビリテーション医学会, 2021年05月
日本語

Evaluating quiet standing posture of post-stroke patients by classifying cerebral infarction and cerebral hemorrhage patients
Dongdong Li, Kohei Kaminishi, Ryosuke Chiba, Kaoru Takakusaki, Masahiko Mukaino, Jun Ota
Advanced Robotics, 35, 13-14, 1, 11, Informa UK Limited, 2021年03月02日, ［査読有り］
研究論文（学術雑誌）

Effect of ankle joint fixation on tibialis anterior muscle activity during split-belt treadmill walking in healthy subjects: A pilot study.
Etsuko Mori, Shigeo Tanabe, Yoichiro Aoyagi, Natsuki Yamakami, Masahiko Mukaino, Wataru Kikuchi, Tomoya Kato, Soichiro Koyama, Tomoko Kayukawa
Turkish journal of physical medicine and rehabilitation, 67, 1, 11, 16, 2021年03月, ［国際誌］
英語, 研究論文（学術雑誌）, OBJECTIVES: This study aims to examine the characteristics of muscle activity change of the tibialis anterior (TA) muscle in healthy adults while they walked on a split-belt treadmill with one fixed ankle. PATIENTS AND METHODS: This randomized controlled trial was conducted between November 2017 and July 2018. Fourteen healthy male individuals (mean age 31.4 years; range, 23 to 50 years) were divided into two groups: right ankle joint fixed by ankle-foot orthosis (fixation group) and no orthosis (control group). Both groups were asked to walk on a treadmill with the same belt speed. After familiarizing with walking on both belts at 5.0 km/h, they walked for 6 min with the right belt slower (2.5 km/h) and the left faster (5.0 km/h). For analysis, the 6 min were divided equally among three time periods. The TA muscle activity was calculated at first and last time periods. We compared muscle activities in time periods (early and late phase) and in groups (fixation and control) using two-way mixed analysis of variance. RESULTS: The TA muscle activity decreased in the late phase regardless of ankle joint fixation, and also decreased in the fixation group regardless of the time periods. There was an interaction between these factors. CONCLUSION: These data show that changes in the TA muscle activity were smaller in the fixation group, suggesting that the ankle joint fixation reduces the adaptation.

人工股関節全置換術後の早期歩行改善に関与する因子の検討
立之 芳裕, 小桑 隆, 山田 純也, 木村 稚佳子, 道川 武紘, 向野 雅彦, 大高 洋平, 藤田 順之, 森田 充浩
日本整形外科学会雑誌, 95, 3, S627, S627, (公社)日本整形外科学会, 2021年03月
日本語

Validity of quantitative assessment of posterior pelvic tilt and contralateral vaulting in hemiplegia using 3D treadmill gait analysis.
Hiroki Tanikawa, Keisuke Inagaki, Kei Ohtsuka, Fumihiro Matsuda, Masahiko Mukaino, Junya Yamada, Yoshikiyo Kanada, Hitoshi Kagaya, Eiichi Saitoh
Topics in stroke rehabilitation, 28, 2, 96, 103, 2021年03月, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: Assessing abnormal gait patterns could indicate compensatory movements, which could be an index for recovery and a process of motor learning. To quantify the degree of posterior pelvic tilt, contralateral vaulting is necessary. OBJECTIVES: This study aimed to develop and evaluate the validity of quantitative indices for posterior pelvic tilt and contralateral vaulting in hemiplegic patients. METHODS: Forty-six healthy control subjects and 112 hemiplegic patients participated in this study. Of the 112 patients, 50 were selected into each abnormal gait pattern group, with some overlap. Three experienced physical therapists observed their walking and graded the severity of the two abnormalities in five levels. An index to quantify each of the two abnormal gait patterns was calculated from the three-dimensional treadmill gait analysis. The index values of patients were compared with those of healthy subjects and with the results of observational gait assessment done by three physical therapists with expertise in gait analysis. RESULTS: The index values were significantly higher in hemiplegic patients than in healthy subjects (28.0% and 44.7% for the posterior pelvic tilt in healthy subjects and patients, respectively and 0.9 and 4.7 for the contralateral vaulting, respectively). A strong correlation was observed between the index value and the median observational rating for two abnormal gait patterns (r = -0.68 and -0.72). CONCLUSIONS: The proposed indices for posterior pelvic tilt and contralateral vaulting are useful for clinical gait analysis, and thus encouraging a more detailed analysis of hemiplegic gait using a motion analysis system.

人工股関節全置換術後の早期歩行改善に関与する因子の検討
立之 芳裕, 小桑 隆, 山田 純也, 木村 稚佳子, 道川 武紘, 向野 雅彦, 大高 洋平, 藤田 順之, 森田 充浩
日本整形外科学会雑誌, 95, 3, S627, S627, (公社)日本整形外科学会, 2021年03月
日本語

臨床歩行分析の可能性　　　　　　　　　　　　　　　
大塚 圭, 向野 雅彦, 松田 文浩, 山田 純也, 谷川 広樹, 土山 和大, 大高 洋平, 才藤 栄一
臨床歩行分析研究会誌, 8, 2, 1, 6, 臨床歩行分析研究会, 2021年
日本語

Evaluation of Postural Sway in Post-stroke Patients by Dynamic Time Warping Clustering.
Dongdong Li, Kohei Kaminishi, Ryosuke Chiba, Kaoru Takakusaki, Masahiko Mukaino, Jun Ota
Frontiers in human neuroscience, 15, 731677, 731677, 2021年, ［国際誌］
英語, 研究論文（学術雑誌）, Post-stroke complications are the second most frequent cause of death and the third leading cause of disability worldwide. The motor function of post-stroke patients is often assessed by measuring the postural sway in the patients during quiet standing, based on sway measures, such as sway area and velocity, which are obtained from temporal variations of the center of pressure. However, such approaches to establish a relationship between the sway measures and patients' demographic factors have hardly been successful (e.g., days after onset). This study instead evaluates the postural sway features of post-stroke patients using the clustering method of machine learning. First, we collected the stroke patients' multi-variable motion-capture standing-posture data and processed them into t s long data slots. Then, we clustered the t-s data slots into K cluster groups using the dynamic-time-warping partition-around-medoid (DTW-PAM) method. The DTW measures the similarity between two temporal sequences that may vary in speed, whereas PAM identifies the centroids for the DTW clustering method. Finally, we used a post-hoc test and found that the sway amplitudes of markers in the shoulder, hip, knee, and center-of-mass are more important than their sway frequencies. We separately plotted the marker amplitudes and frequencies in the medial-lateral direction during a 5-s data slot and found that the post-stroke patients' postural sway frequency lay within the bandwidth of 0.5-1.5 Hz. Additionally, with an increase in the onset days, the cluster index of cerebral hemorrhage patients gradually transits in a four-cluster solution. However, the cerebral infarction patients did not exhibit such pronounced transitions over time. Moreover, we found that the postural-sway amplitude increased in clusters 1, 3, and 4. However, the amplitude of cluster 2 did not follow this pattern, owing to age effects related to the postural sway changes with age. A rehabilitation doctor can utilize these findings as guidelines to direct the post-stroke patient training.

An Affordable, User-friendly Telerehabilitation System Assembled Using Existing Technologies for Individuals Isolated With COVID-19: Development and Feasibility Study.
Masahiko Mukaino, Tsuyoshi Tatemoto, Nobuhiro Kumazawa, Shigeo Tanabe, Masaki Katoh, Eiichi Saitoh, Yohei Otaka
JMIR rehabilitation and assistive technologies, 7, 2, e24960, 2020年12月10日, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: Isolation due to a COVID-19 infection can limit activities and cause physical and mental decline, especially in older adults and people with disabilities. However, due to limited contact, adequate rehabilitation is difficult to provide for quarantined patients. Telerehabilitation technology could be a solution; however, issues specific to COVID-19 should be taken into consideration, such as strict quarantine and respiratory symptoms, as well as accessibility to deal with rapid increases in need due to the pandemic. OBJECTIVE: This study aims to develop and to investigate the feasibility of a telerehabilitation system for patients who are quarantined due to COVID-19 by combining existing commercial devices and computer applications. METHODS: A multidisciplinary team has identified the requirements for a telerehabilitation system for COVID-19 and developed the system to satisfy those requirements. In the subsequent feasibility study, patients diagnosed with COVID-19 (N=10; mean age 60 years, SD 18 years) were included. A single session of telerehabilitation consisted of stretching exercises, a 15-minute exercise program, and a video exercise program conducted under real-time guidance by a physical therapist through a video call. The system included a tablet computer, a pulse oximeter, videoconferencing software, and remote control software. The feasibility of the system was evaluated using the Telemedicine Satisfaction Questionnaire (TSQ; 14 items) and an additional questionnaire on the telerehabilitation system (5 items). Each item was rated from "1 = strongly disagree" to "5 = strongly agree." RESULTS: The telerehabilitation system was developed by combining existing devices and applications, including a pulse oximeter and remote control mechanism, to achieve user-friendliness, affordability, and safety, which were determined as the system requirements. In the feasibility study, 9 out of 10 patients were able to use the telerehabilitation system without any on-site help. On the TSQ, the mean score for each item was 4.7 (SD 0.7), and in the additional items regarding telerehabilitation, the mean score for each item was 4.3 (SD 1.0). CONCLUSIONS: These findings support the feasibility of this simple telerehabilitation system in quarantined patients with COVID-19, encouraging further investigation on the merit of the system's use in clinical practice.

Robot-assisted Gait Training Using Welwalk in Hemiparetic Stroke Patients: An Effectiveness Study with Matched Control.
Takuma Ii, Satoshi Hirano, Shigeo Tanabe, Eiichi Saitoh, Junya Yamada, Masahiko Mukaino, Makoto Watanabe, Shigeru Sonoda, Yohei Otaka
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 29, 12, 105377, 105377, 2020年12月, ［国際誌］
英語, 研究論文（学術雑誌）, OBJECTIVE: Although studies on the efficacy of the rehabilitation robot are increasing, there are few reports using the robot for gait training in the actual clinical setting. This study aimed to investigate the effectiveness of gait training using Welwalk in hemiparetic stroke patients in a real clinical setting. MATERIALS AND METHODS: This prospective study included 36 hemiparetic stroke patients who underwent gait training using Welwalk. We examined the walking ability improvement efficiency using Functional Independence Measure (FIM)-walk as the primary outcome, which was compared with that of 36 patients (matched control group) who underwent conventional rehabilitation. Other outcomes were the actual gait training period using Welwalk, raw FIM-walk score, lower extremity motor functions score in Stroke Impairment Assessment Set at discharge, and duration from stroke onset until discharge. RESULTS: The improvement efficiency of the FIM-walk was significantly higher in the Welwalk group than in the matched control group (control 0.48 ± 0.31, Welwalk 0.80 ± 0.38, p-value < 0.001). The mean gait training period using Welwalk was 5 weeks. No significant differences were found in other outcomes between the Welwalk group and the matched control group. CONCLUSION: This study demonstrated the effectiveness of gait training using Welwalk on the improvement efficiency of the FIM-walk in hemiparetic stroke patients in an actual clinical setting.

振動刺激の介入肢位の違いが下腿三頭筋の痙縮に及ぼす影響 立位と長座位の比較検討　　　　　　　　　　　　　　　
近藤 輝, 谷川 広樹, 向野 雅彦, 桂林 佑太, 伊藤 翔太, 加藤 正樹, 寺西 利生, 大高 洋平, 才藤 栄一
The Japanese Journal of Rehabilitation Medicine, 57, 秋季特別号, S458, S458, (公社)日本リハビリテーション医学会, 2020年11月
日本語

ボツリヌス療法により歩容の改善を得た慢性期脳卒中患者の1例　　　　　　　　　　　　　　　
小関 秀宙, 谷川 広樹, 加賀谷 斉, 近藤 輝, 伊藤 翔太, 寺西 利生, 向野 雅彦, 大高 洋平, 才藤 栄一
The Japanese Journal of Rehabilitation Medicine, 57, 秋季特別号, S460, S460, (公社)日本リハビリテーション医学会, 2020年11月
日本語

振動刺激の介入肢位の違いが下腿三頭筋の痙縮に及ぼす影響 立位と長座位の比較検討　　　　　　　　　　　　　　　
近藤 輝, 谷川 広樹, 向野 雅彦, 桂林 佑太, 伊藤 翔太, 加藤 正樹, 寺西 利生, 大高 洋平, 才藤 栄一
The Japanese Journal of Rehabilitation Medicine, 57, 秋季特別号, S458, S458, (公社)日本リハビリテーション医学会, 2020年11月
日本語

ボツリヌス療法により歩容の改善を得た慢性期脳卒中患者の1例　　　　　　　　　　　　　　　
小関 秀宙, 谷川 広樹, 加賀谷 斉, 近藤 輝, 伊藤 翔太, 寺西 利生, 向野 雅彦, 大高 洋平, 才藤 栄一
The Japanese Journal of Rehabilitation Medicine, 57, 秋季特別号, S460, S460, (公社)日本リハビリテーション医学会, 2020年11月
日本語

Development of an abnormal gait analysis system in gait exercise assist robot 'Welwalk' for hemiplegic stroke patients
Issei Nakashima, Daisuke Imoto, Satoshi Hirano, Masahiko Mukaino, Masayuki Imaida, Eiichi Saitoh, Yohei Otaka
Proceedings of the IEEE RAS and EMBS International Conference on Biomedical Robotics and Biomechatronics, 2020-November, 1030, 1035, 2020年11月
研究論文（国際会議プロシーディングス）

三次元トレッドミル歩行分析装置を用いた人工股関節置換術患者の歩行解析
立之 芳裕, 武田 太樹, 小桑 隆, 山田 純也, 木村 稚佳子, 道川 武紘, 向野 雅彦, 大高 洋平, 藤田 順之, 森田 充浩
日本整形外科学会雑誌, 94, 8, S1912, S1912, (公社)日本整形外科学会, 2020年09月
日本語

COVID-19(第2回) COVID-19現場リポート 藤田医科大学病院の経験と今後の対応
向野 雅彦, 柴田 斉子, 加藤 正樹, 加賀谷 斉, 大高 洋平
Journal of Clinical Rehabilitation, 29, 9, 856, 862, 医歯薬出版(株), 2020年08月
日本語

【リハビリテーションにおけるロボット技術の最近の進歩】片麻痺患者の歩行練習支援ロボット「ウェルウォーク」の現在と未来
平野 哲, 大高 洋平, 向野 雅彦, 才藤 栄一
脊椎脊髄ジャーナル, 33, 8, 793, 798, (株)三輪書店, 2020年08月
日本語

Persistent Effect of Gait Exercise Assist Robot Training on Gait Ability and Lower Limb Function of Patients With Subacute Stroke: A Matched Case–Control Study With Three-Dimensional Gait Analysis
Yiji Wang, Masahiko Mukaino, Satoshi Hirano, Hiroki Tanikawa, Junya Yamada, Kei Ohtsuka, Takuma Ii, Eiichi Saitoh, Yohei Otaka
Frontiers in Neurorobotics, 14, Frontiers Media SA, 2020年07月24日, ［査読有り］
研究論文（学術雑誌）

Development and assessment of a home environment checklist to evaluate mismatch between patients' ability and home environment.
Masahiko Mukaino, Birgit Prodinger, Yuki Okouchi, Kouji Mizutani, Yuki Senju, Megumi Suzuki, Eiichi Saitoh
Annals of physical and rehabilitation medicine, 63, 4, 288, 295, 2020年07月, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: Modification of the home environment, together with rehabilitative interventions, is important for maximizing the level of functioning after an individual with disability undergoes rehabilitation in the hospital. OBJECTIVES: We developed a simple screening scale - the home environment checklist (HEC) - to identify any mismatch between an individual's abilities and their home environment to help clinicians monitor the appropriateness of the home environment to which individuals with disability will be discharged. We also examined the psychometric properties of the HEC. METHODS: The HEC was developed by a multidisciplinary panel of rehabilitation experts using information routinely collected in rehabilitation clinics before discharge. The reliability of the checklist was assessed in 60 individuals undergoing rehabilitation. The inter-rater agreement and internal consistency of the scale were assessed by weighted kappa statistics and Cronbach's alpha, respectively. Rasch analysis was performed with 244 rehabilitation individuals to evaluate the internal construct validity, and the known-groups validity was confirmed by a comparison of the daily activity levels of 30 individuals with disabilities under rehabilitation to the HEC score. RESULTS: The HEC was developed as a simple, 10-item checklist. The weighted kappa statistics ranged from 0.73 to 0.93, indicating excellent inter-rater reliability. Cronbach's alpha was 0.92, indicating high internal consistency. Rasch analysis with a testlet approach on 3 subscales demonstrated a good fit with the Rasch model (χ2=13.2, P=0.153), and the demonstrated unidimensionality and absence of differential item functioning supported the internal construct validity of the HEC. HEC scores were significantly different (P<.01) among individuals with disability and 3 levels of restrictions in their activities (no limitation, home-bound, and bed-bound), which demonstrates the known-groups validity of the HEC. CONCLUSIONS: The HEC has good reliability and validity, which supports its utility in rehabilitation clinics.

回復期リハビリテーション病棟におけるリハビリテーション科医師の役割 大学病院における先進リハビリテーション病棟　　　　　　　　　　　　　　　
大高 洋平, 向野 雅彦
The Japanese Journal of Rehabilitation Medicine, 57, 特別号, S340, S340, (公社)日本リハビリテーション医学会, 2020年07月
日本語

低侵襲人工股関節全置換術(MIS-THA)術後の長期的な回復過程の検討　　　　　　　　　　　　　　　
小桑 隆, 向野 雅彦, 大塚 圭, 山田 純也, 近藤 環, 加賀谷 斉, 才藤 栄一, 森田 充浩, 大高 洋平
The Japanese Journal of Rehabilitation Medicine, 57, 特別号, 2, 3, (公社)日本リハビリテーション医学会, 2020年07月
日本語

片麻痺患者の回復期リハビリテーションにおける歩行機能の変化 三次元歩行分析を用いた予備的検討　　　　　　　　　　　　　　　
牧野 稜, 向野 雅彦, 大塚 圭, 前田 寛文, 谷川 広樹, 松田 文浩, 山田 純也, 柴田 斉子, 才藤 栄一, 大高 洋平
The Japanese Journal of Rehabilitation Medicine, 57, 特別号, 2, 3, (公社)日本リハビリテーション医学会, 2020年07月
日本語

状態悪化により回復期リハビリテーション病棟から退棟した患者の転帰　　　　　　　　　　　　　　　
前田 寛文, 向野 雅彦, 柴田 斉子, 角田 哲也, 八木橋 恵, 名倉 高広, 牧野 稜, 才藤 栄一, 大高 洋平
The Japanese Journal of Rehabilitation Medicine, 57, 特別号, 2, 5, (公社)日本リハビリテーション医学会, 2020年07月
日本語

装具が片麻痺患者の歩行安定性に及ぼす効果　　　　　　　　　　　　　　　
土山 和大, 向野 雅彦, 大塚 圭, 谷川 広樹, 松田 文浩, 山田 純也, 大高 洋平, 才藤 栄一
The Japanese Journal of Rehabilitation Medicine, 57, 特別号, 2, 4, (公社)日本リハビリテーション医学会, 2020年07月
日本語

脳卒中後の回復期リハビリテーションにおける活動量の変化　　　　　　　　　　　　　　　
向野 雅彦, 青嶋 保志, 小笠原 隆行, 鈴木 卓弥, 松田 文浩, 松浦 広昂, 大高 洋平, 才藤 栄一
The Japanese Journal of Rehabilitation Medicine, 57, 特別号, 3, 3, (公社)日本リハビリテーション医学会, 2020年07月
日本語

ICFリハビリテーションセットを用いた生活機能評価 Rasch分析を用いた標準化指標作成の取り組み　　　　　　　　　　　　　　　
舟橋 怜佑, 向野 雅彦, 大高 洋平, 千手 佑樹, 才藤 栄一
The Japanese Journal of Rehabilitation Medicine, 57, 特別号, 3, 4, (公社)日本リハビリテーション医学会, 2020年07月
日本語

ICFリハビリテーションセットの臨床使用における評点の検者間信頼性に関わる検討　　　　　　　　　　　　　　　
千手 佑樹, 向野 雅彦, 才藤 栄一, 大高 洋平
The Japanese Journal of Rehabilitation Medicine, 57, 特別号, 3, 6, (公社)日本リハビリテーション医学会, 2020年07月
日本語

活動量計測システムを利用し算出した活動コスト指数とADLの関係性の検討　　　　　　　　　　　　　　　
水野 江美, 角田 哲也, 平野 哲, 向野 雅彦, 大高 洋平, 青嶋 保志, 鈴木 卓弥, 小笠原 隆行
The Japanese Journal of Rehabilitation Medicine, 57, 特別号, 3, 3, (公社)日本リハビリテーション医学会, 2020年07月
日本語

食事動作において頻用される上肢関節運動の組み合わせと運動範囲の検討　　　　　　　　　　　　　　　
太田 皓文, 向野 雅彦, 大河内 由紀, 佐々 裕果, 井上 由加里, 芝草 愛, 松浦 翔, 大高 洋平, 才藤 栄一
The Japanese Journal of Rehabilitation Medicine, 57, 特別号, 3, 4, (公社)日本リハビリテーション医学会, 2020年07月
日本語

脳卒中後の回復期リハビリテーションにおける歩行機能の変化 一症例における検討　　　　　　　　　　　　　　　
名倉 宏高, 向野 雅彦, 大塚 圭, 前田 寛文, 谷川 広樹, 松田 文浩, 山田 純也, 柴田 斉子, 才藤 栄一, 大高 洋平
The Japanese Journal of Rehabilitation Medicine, 57, 特別号, 4, 4, (公社)日本リハビリテーション医学会, 2020年07月
日本語

Staying Active in Isolation: Telerehabilitation for Individuals With the Severe Acute Respiratory Syndrome Coronavirus 2 Infection.
Masahiko Mukaino, Tsuyoshi Tatemoto, Nobuhiro Kumazawa, Shigeo Tanabe, Masaki Katoh, Eiichi Saitoh, Yohei Otaka
American journal of physical medicine & rehabilitation, 99, 6, 478, 479, 2020年06月, ［査読有り］, ［国際誌］
英語

リハの現場で役立つ!目で見る動作・歩行分析 脳卒中 三次元トレッドミル歩行分析と臨床指向的分析
大塚 圭, 向野 雅彦, 松田 文浩, 山田 純也, 谷川 広樹, 大高 洋平, 才藤 栄一
Journal of Clinical Rehabilitation, 29, 3, 213, 221, 医歯薬出版(株), 2020年03月
日本語

The effect of using Gait Exercise Assist Robot (GEAR) on gait pattern in stroke patients: a cross-sectional pilot study.
Katoh D, Tanikawa H, Hirano S, Mukaino M, Yamada J, Sasaki S, Ohtsuka K, Katoh M, Saitoh E
Topics in stroke rehabilitation, 27, 2, 103, 109, 2020年03月, ［査読有り］, ［国際誌］
英語, Background: The Gait Exercise Assist Robot (GEAR) has been developed to support gait training for stroke patients. The GEAR can assist paretic lower limb swing and stance stability, which make it possible to practice walking without excessive compensation movements. However, there are no studies to-date that investigate the effect of the GEAR on gait pattern.Objectives: The purpose of this study was to clarify the effect of gait training on gait pattern using the GEAR for rehabilitation in stroke patients.Methods: Fifteen hemiplegic patients who received gait training using the GEAR were recruited (GEAR group). As a control group, hemiplegic patients who did not receive gait training using the GEAR were selected for each patient in the GEAR group from 114 cases in our hospital database. Primary outcomes were index values indicating the degree of 10 abnormal gait patterns. Secondary outcomes were spatiotemporal factors and comfortable overground gait velocity.Results: Index values for abnormal gait patterns were significantly lower in the GEAR group compared to the control group for insufficient knee flexion during the swing phase, hip hiking, and excessive lateral shift of the trunk over the unaffected-side (p < .05). The comfortable overground gait velocity, stride length, and unaffected-step length in the GEAR group were significantly better than in the control group (p < .05).Conclusions: Gait training using the GEAR had effects on reducing abnormal gait patterns and improving gait velocity, stride, and unaffected-side step length compared to conventional gait training alone in individuals recovering from stroke-induced hemiplegia.

ICFリハビリテーションセットの心身機能項目における患者-医療者間の評価の一致性(Interrater agreement between clinician ratings and patient self-assessments for body function categories of ICF Rehabilitation Set)
千手 佑樹, 向野 雅彦, 尾関 恩, 渡邉 誠, 大河内 由紀, 水谷 公司, 才藤 栄一, 園田 茂
Japanese Journal of Comprehensive Rehabilitation Science, 11(2020), 9, 16, (一社)回復期リハビリテーション病棟協会, 2020年02月
英語

ICFリハビリテーションセットの入院リハビリテーションにおける適用可能性:回復期リハビリテーション病棟入院患者に適用可能な項目セットの作成とその妥当性の検討(Feasibility of the International Classification of Functioning, Disability and Health Rehabilitation Set for inpatient rehabilitation: Selection and validity of a set of categories for inpatients in a convalescent rehabilitation ward)
舟橋 怜佑, 向野 雅彦, 大高 洋平, 千手 祐樹, 米田 千賀子, 尾関 保則, 清水 康裕, 小池 知治, 才藤 栄一
Japanese Journal of Comprehensive Rehabilitation Science, 11(2020), 1, 8, (一社)回復期リハビリテーション病棟協会, 2020年02月
英語

Supporting the clinical use of the ICF in Japan - development of the Japanese version of the simple, intuitive descriptions for the ICF Generic-30 set, its operationalization through a rating reference guide, and interrater reliability study.
Masahiko Mukaino, Birgit Prodinger, Shin Yamada, Yuki Senju, Shin-Ichi Izumi, Shigeru Sonoda, Melissa Selb, Eiichi Saitoh, Gerold Stucki
BMC health services research, 20, 1, 66, 66, 2020年01月30日, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）, BACKGROUND: The World Health Organization developed the International Classification of Functioning, Disability, and Health (ICF) in 2001 and has been in the process of implementing it in clinics since then. Current international efforts to implement ICF in rehabilitation clinics include the implementation of ICF Core Sets and the development of simple, intuitive descriptions for the ICF Generic-30 Set (also called Rehabilitation Set). The present study was designed to operationalize these ICF tools for clinical practice in Japan. This work included 1) the development of the Japanese version of the simple, intuitive descriptions for the ICF Generic-30 Set, 2) the development of a rating reference guide for Activity and Participation categories, and 3) the examination of the interrater reliability of rating Activity and Participation categories. METHODS: The Japanese version of the simple, intuitive descriptions for the ICF Generic-30 Set was developed following the process employed to develop the Chinese and Italian versions. For further operationalization of this ICF Set in practice, a rating reference guide was developed. The development of the rating reference guide involved the following steps: 1) a trial of rating patients by several raters, 2) cognitive interviewing of the raters to analyse the thinking process involved in rating, 3) drafting of the rating reference guide, and 4) review by ICF specialists to confirm consistency with the original ICF concepts. After the rating reference guide was developed, interrater reliability of the rating with the reference guide was determined. Interrater reliability was examined using weighted kappa statistics with linear weight. RESULTS: Through the pre-defined process, the Japanese version of the simple, intuitive descriptions for 30 categories of the ICF Generic-30 Set and the rating reference guides for 21 Activity and Participation categories were successfully developed. The weighted kappa statistics ranged from 0.61 to 0.85, showing substantial to excellent agreement of the ratings between raters. CONCLUSIONS: The present study demonstrates that ICF categories can be translated into clinical practice. Collaboration between clinicians and researchers would further enhance the implementation of the ICF in Japan.

Gait characteristics of post-stroke hemiparetic patients with different walking speeds
Wang, Y., Mukaino, M., Ohtsuka, K., Otaka, Y., Tanikawa, H., Matsuda, F., Tsuchiyama, K., Yamada, J., Saitoh, E.
International journal of rehabilitation research. Internationale Zeitschrift fur Rehabilitationsforschung. Revue internationale de recherches de readaptation, 43, 1, 69, 75, 2020年, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

日常生活活動で頻回に用いられる上肢動作パターンと運動範囲の検討　　　　　　　　　　　　　　　
芝草 愛, 向野 雅彦, 太田 皓文, 大河内 由紀, 才藤 栄一
日本作業療法学会抄録集, 53回, PA, 1G05, (一社)日本作業療法士協会, 2019年09月, ［査読有り］
日本語

On-site Evaluation of Rehabilitation Patients Monitoring System Using Distributed Wireless Gateways
Kenichi Matsunaga, Takayuki Ogasawara, Junichi Kodate, Masahiko Mukaino, Eiichi Saitoh
Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, 2019, 3195, 3198, 2019年07月, ［国際誌］
英語, 研究論文（国際会議プロシーディングス）

関節抵抗トルク測定装置による速度依存的な痙縮評価　　　　　　　　　　　　　　　
伊藤 翔太, 谷川 広樹, 向野 雅彦, 近藤 輝, 藤村 健太, 寺西 利生, 大塚 圭, 加藤 正樹, 加賀谷 斉, 才藤 栄一
The Japanese Journal of Rehabilitation Medicine, 56, 特別号, 2, 1, (公社)日本リハビリテーション医学会, 2019年05月
日本語

加齢が健常者歩行のToe clearanceとばらつきに与える影響
村上 涼, 大塚 圭, 向野 雅彦, 山田 純也, 松田 文浩, 土山 和大, 才藤 栄一
愛知県理学療法学会誌, 31, 特別号, 38, 38, (NPO)愛知県理学療法学会, 2019年03月
日本語

回復期脳卒中患者の24時間超継続的活動モニタリングに関する予備的検討(Preliminary study on activity monitoring for over 24 hours among stroke patients in a rehabilitation ward)
Matsuura Hirotaka, Mukaino Masahiko, Ogasawara Takayuki, Aoshima Yasushi, Suzuki Takuya, Inukai Ayaka, Hattori Emi, Saitoh Eiichi
Japanese Journal of Comprehensive Rehabilitation Science, 10(2019), 37, 41, (一社)回復期リハビリテーション病棟協会, 2019年
英語

Validity of simplified, calibration-less exercise intensity measurement using resting heart rate during sleep: A method-comparison study with respiratory gas analysis
Matsuura, H., Mukaino, M., Otaka, Y., Kagaya, H., Aoshima, Y., Suzuki, T., Inukai, A., Hattori, E., Ogasawara, T., Saitoh, E.
BMC Sports Science, Medicine and Rehabilitation, 11, 1, 27, 27, 2019年, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Influence of clinical experience and instruction on typical cases on the inter-rater reliability of observational gait analysis　　　　　　　　　　　　　　　
Tanikawa H, Ohtsuka K, Yamada J, Mukaino M, Matsuda F, Kagaya H, Saitoh E, Kanada Y, Hashimoto S
Jpn J Compr Rehabil Sci, 10, 14, 20, 2019年, ［査読有り］

Designing a robotic smart home for everyone, especially the elderly and people with disabilities
Tanabe S, Saitoh E, Koyama S, Kiyono K, Tatemoto T, Kumazawa N, Kagaya H, Otaka Y, Mukaino M, Tsuzuki A, Ota H, Hirano S, Kanada Y
Fujita Med J, 5, 2, 31, 35, 藤田学園医学会, 2019年, ［査読有り］
英語,

We initiated the Robotic Smart Home (RSH) project to develop a comfortable, safe home environment for all people, including the elderly and individuals with disabilities. An important consideration when introducing robots into a home environment is the confined living space, the so-called space problem. The RSH project plans to simultaneously develop robots and an architectural design for living spaces to create an optimal home environment that will help elderly people live independently at home for longer periods. The RSH accommodates the following three robotics and assistive systems: mobility and transfer assist system, operational assist system, and information assist system. The mobility and transfer assist system includes three types of devices (lifting type, lateral-transfer type, and suspension type), which can be available to users as appropriate according to the severity of their disability. The operational assist system combines a hand robot with an environmental control system for the convenience of users. An information assist system connects the RSH with remote locations for communication. Inside the RSH, a home automation and monitoring system connected to the Internet of Things provides residents with comfort and security. As part of this project, two RSH centers have been established for effective facility adoption.

Development and verification of a cane for treadmill gait training
Tanikawa H, Hirano S, Tanabe S, Fuse I, Ohtsuka K, Mukaino M, Watanabe I, Katoh D, Uno A, Kagaya H, Saitoh E
Jpn J Compr Rehabil Sci, 10, 21, 28, 2019年, ［査読有り］

Application for rehabilitation medicine using wearable textile “hitoe”
Takayuki Ogasawara, Kenichi Matsunaga, Hiroki Ito, Masahiko Mukaino
NTT Technical Review, 16, 9, 6, 12, 2018年09月01日
研究論文（学術雑誌）

Intra- and inter-rater reliability and validity of the tandem gait test for the assessment of dynamic gait balance
Soichiro Koyama, Shigeo Tanabe, Norihide Itoh, Norihide Itoh, Eiichi Saitoh, Kazuya Takeda, Satoshi Hirano, Kei Ohtsuka, Masahiko Mukaino, Ryuzo Yanohara, Hiroaki Sakurai, Yoshikiyo Kanada
European Journal of Physiotherapy, 20, 3, 135, 140, 2018年07月03日, ［査読有り］
研究論文（学術雑誌）

【片麻痺の課題指向型リハビリテーションの潮流】 ロボットを使用した課題指向型リハビリテーション医療　　　　　　　　　　　　　　　
近藤 和泉, 橋爪 美春, 加藤 健治, 向野 雅彦
Journal of Clinical Rehabilitation, 27, 6, 538, 542, 医歯薬出版(株), 2018年06月
日本語

The impact of ankle-foot orthoses on toe clearance strategy in hemiparetic gait: A cross-sectional study
Kannit Pongpipatpaiboon, Masahiko Mukaino, Fumihiro Matsuda, Kei Ohtsuka, Hiroki Tanikawa, Junya Yamada, Kazuhiro Tsuchiyama, Eiichi Saitoh
Journal of NeuroEngineering and Rehabilitation, 15, 1, 41, 2018年05月23日, ［査読有り］
英語, 研究論文（学術雑誌）

Quantitative assessment for flexed-elbow deformity during gait following botulinum toxin A treatment
Hiroki Tanikawa, Hitoshi Kagaya, Keisuke Inagaki, Yusuke Kotsuji, Keita Suzuki, Kenta Fujimura, Masahiko Mukaino, Satoshi Hirano, Eiichi Saitoh, Yoshikiyo Kanada
Gait and Posture, 62, 409, 414, 2018年05月01日, ［査読有り］
英語, 研究論文（学術雑誌）

ICFリハビリテーションセットb項目における患者アンケート調査と医療者評価の比較　　　　　　　　　　　　　　　
千手 佑樹, 向野 雅彦, 渡邉 誠, 大河内 由紀, 水谷 公司, 才藤 栄一, 園田 茂
The Japanese Journal of Rehabilitation Medicine, 55, 特別号, 4, 8, (公社)日本リハビリテーション医学会, 2018年05月
日本語

脳卒中片麻痺者における平地歩行とトレッドミル歩行の運動学的因子の比較　　　　　　　　　　　　　　　
山田 純也, 向野 雅彦, 大塚 圭, 松田 文浩, 谷川 広樹, 土山 和大, 日高 雅大, 伊東 慶, 安藤 大智, 王 裕香, 才藤 栄一
The Japanese Journal of Rehabilitation Medicine, 55, 特別号, 4, 3, (公社)日本リハビリテーション医学会, 2018年05月
日本語

国際生活機能分類を用いた生活機能の標準化指標作成の取り組み　　　　　　　　　　　　　　　
向野 雅彦, 才藤 栄一, 園田 茂, 岡崎 英人, 河村 美穂, 米田 千賀子, 尾関 保則, 小口 和代, 清水 康裕, 小池 知治, 戸田 芙美, 近藤 和泉
The Japanese Journal of Rehabilitation Medicine, 55, 特別号, 4, 7, (公社)日本リハビリテーション医学会, 2018年05月
日本語

Clinical-oriented three-dimensional gait analysis method for evaluating gait disorder
Masahiko Mukaino, Kei Ohtsuka, Hiroki Tanikawa, Fumihiro Matsuda, Junya Yamada, Norihide Itoh, Eiichi Saitoh
Journal of Visualized Experiments, 2018, 133, 2018年03月04日, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

【歩行と理学療法I:臨床歩行分析の基礎と実際】 中枢神経疾患患者の理学療法における臨床歩行分析の実際　　　　　　　　　　　　　　　
大塚 圭, 向野 雅彦, 谷川 広樹, 才藤 栄一
理学療法, 35, 2, 156, 168, (株)メディカルプレス, 2018年02月
日本語

【リハビリテーションにおけるICFの活用】 ICFに基づく全般評価システムの作成と臨床活用
向野 雅彦
総合リハビリテーション, 46, 1, 19, 22, (株)医学書院, 2018年01月
日本語

Quantitative assessment of knee extensor thrust, flexed-knee gait, insufficient knee flexion during the swing phase, and medial whip in hemiplegia using three-dimensional treadmill gait analysis
Norikazu Hishikawa, Hiroki Tanikawa, Kei Ohtsuka, Masahiko Mukaino, Keisuke Inagaki, Fumihiro Matsuda, Toshio Teranishi, Yoshikiyo Kanada, Hitoshi Kagaya, Eiichi Saitoh
Topics in Stroke Rehabilitation, 25, 8, 548, 553, 2018年01月01日, ［査読有り］, ［国際誌］
英語, 研究論文（学術雑誌）

Welwalk facilitate early improvement in walking independence of stroke patients with hemiplegia
S. Hirano, E. Saitoh, H. Kagaya, S. Sonoda, M. Mukaino, T. Tsunoda, S. Tanabe, J. Yamada, A. Suzuki, H. Konosu
Annals of Physical and Rehabilitation Medicine, 61, e93, Elsevier Masson SAS, 2018年, ［査読有り］
英語, 研究論文（学術雑誌）

ウェルウォークが片麻痺患者の歩行自立度回復に与える影響　　　　　　　　　　　　　　　
平野 哲, 才藤 栄一, 園田 茂, 加賀谷 斉, 角田 哲也, 布施 郁子, 波多野 和樹, 舟橋 怜佑, 向野 雅彦, 尾関 恩, 田辺 茂雄, 大塚 圭
The Japanese Journal of Rehabilitation Medicine, 54, 秋季特別号, S270, S270, (公社)日本リハビリテーション医学会, 2017年09月
日本語

Regulation of RhoA by STAT3 coordinates glial scar formation
Francois Renault-Mihara, Masahiko Mukaino, Munehisa Shinozaki, Hiromi Kumamaru, Satoshi Kawase, Matthieu Baudoux, Toshiki Ishibashi, Soya Kawabata, Yuichiro Nishiyama, Keiko Sugai, Kaori Yasutake, Seiji Okada, Masaya Nakamura, Hideyuki Okano
JOURNAL OF CELL BIOLOGY, 216, 8, 2533, 2550, 2017年08月, ［査読有り］
英語, 研究論文（学術雑誌）

Reliability and validity of a force-instrumented treadmill for evaluating balance: A preliminary study of feasibility in healthy young adults
Zhou Yuntao, Zhou Yuntao, Izumi Kondo, Masahiko Mukaino, Shigeo Tanabe, Toshio Teranishi, Takuma Ii, Kensuke Oono, Soichiro Koyama, Yoshikiyo Kanada, Eiichi Saitoh
Hong Kong Physiotherapy Journal, 36, 49, 56, 2017年06月01日, ［査読有り］
英語, 研究論文（学術雑誌）

脳卒中片麻痺者におけるToe clearance獲得戦略の分析(Analysis of strategies used by hemiplegic stroke patients to achieve toe clearance)
松田 文浩, 向野 雅彦, 大塚 圭, 谷川 広樹, 土山 和大, 寺西 利生, 金田 嘉清, 加賀谷 斉, 才藤 栄一
Japanese Journal of Comprehensive Rehabilitation Science, 7(2016), 111, 118, (一社)回復期リハビリテーション病棟協会, 2017年01月
英語

Objective Measurement of Dynamic Balance Function by the Simultaneous Measurement of the Center of Gravity (COG) and Center of Pressure (COP)
Masahiko Mukaino, Fumihiro Matsuda, Ryoma Sassa, Kei Ohtsuka, Nobuhiro Kumazawa, Kazuhiro Tsuchiyama, Shigeo Tanabe, Eiichi Saitoh
INTELLIGENT AUTONOMOUS SYSTEMS 14, 531, 69, 75, 2017年, ［査読有り］
英語, 研究論文（国際会議プロシーディングス）

Biomechanical factors behind toe clearance during the swing phase in hemiparetic patients
Fumihiro Matsuda, Masahiko Mukaino, Kei Ohtsuka, Hiroki Tanikawa, Kazuhiro Tsuchiyama, Toshio Teranishi, Yoshikiyo Kanada, Hitoshi Kagaya, Eiichi Saitoh
TOPICS IN STROKE REHABILITATION, 24, 3, 177, 182, 2017年, ［査読有り］
英語, 研究論文（学術雑誌）

After-effects of pedaling exercise on spinal excitability and spinal reciprocal inhibition in patients with chronic stroke
Akira Tanuma, Toshiyuki Fujiwara, Tomofumi Yamaguchi, Takanori Ro, Hirotaka Arano, Shintaro Uehara, Kaoru Honaga, Masahiko Mukaino, Akio Kimura, Meigen Liu
INTERNATIONAL JOURNAL OF NEUROSCIENCE, 127, 1, 73, 79, 2017年, ［査読有り］
英語, 研究論文（学術雑誌）

日常生活における上肢頻用動作に基づく客観的上肢機能評価法の検討　　　　　　　　　　　　　　　
太田 皓文, 向野 雅彦, 大河内 由紀, 保木本 のぞみ, 才藤 栄一
日本作業療法学会抄録集, 50回, OA, 2, (一社)日本作業療法士協会, 2016年09月, ［査読有り］
日本語

Feasibility of a Simplified, Clinically Oriented, Three-dimensional Gait Analysis System for the Gait Evaluation of Stroke Patients
Mukaino Masahiko, Ohtsuka Kei, Tsuchiyama Kazuhiro, Matsuda Fumihiro, Inagaki Keisuke, Yamada Junya, Tanikawa Hiroki, Saitoh Eiichi
Progress in Rehabilitation Medicine, 1, 1, 1, 8, 公益社団法人 日本リハビリテーション医学会, 2016年07月, ［査読有り］, ［国内誌］
英語, <p>Objective: Although previous studies have evidenced the value ofthree-dimensional gait analysis (3DGA) for evaluating gait disorder, the time-consumingmeasurement process and space requirement has hampered its use in the clinical setting.The aim of this study was to examine the feasibility of a simplified 3DGA system forstroke patients. Methods: Thirteen pairs of stroke patients and age- (± 1year), gender-, and gait speed- (± 0.5 m/s) matched controls were drawn from the FujitaHealth University gait analysis database. 3DGA was performed using theKinemaTracer® treadmill gait analysis system. Comparisons of thespatiotemporal and kinematic parameters were performed between stroke patients and matchedcontrols. The correlations between items from the Wisconsin Gait Scale (WGS) and 3DGA datain stroke patients were also investigated. Results: 3DGA measurements clearlyshowed reduced toe clearance, hip flexion, and knee flexion in stroke patients comparedwith the matched controls. In contrast, significant increases were observed in hipelevation, shoulder elevation, shoulder lateral shift, and step width in stroke patients.For the four items drawn from the WGS, a significant correlation with three 3DGAparameters was observed: stance time on the impaired side, stance width, and knee flexionfrom toe off to midswing. Conclusions: In this study, significant differencesin gait parameters of stroke patients and age-, gender-, and speed-matched controls werefound using a simplified 3DGA system. A significant correlation with WGS was alsoobserved. These results support the validity of the clinical measurement of gaitparameters using a simplified 3DGA system.</p>

回復期リハビリテーション病棟における脳卒中患者の作業療法内容調査　　　　　　　　　　　　　　　
宮坂 裕之, 國分 実伸, 川上 健司, 奥山 夕子, 向野 雅彦, 沢田 光思郎, 加藤 正樹, 寺西 利生, 園田 茂, 才藤 栄一
The Japanese Journal of Rehabilitation Medicine, JARM2016, I181, I181, (公社)日本リハビリテーション医学会, 2016年06月
日本語

急性期病院におけるリハビリテーション専門職配置の効果 呼吸器内科病棟でのADL維持向上等体制加算算定の取り組み
平野 明日香, 加藤 正樹, 藤村 健太, 早川 美和子, 加賀谷 斉, 向野 雅彦, 才藤 栄一
理学療法学, 43, 3, 255, 262, (公社)日本理学療法士協会, 2016年06月
日本語

急性期病院におけるリハビリテーション専門職配置の効果 呼吸器内科病棟でのADL維持向上等体制加算算定の取り組み
平野 明日香, 加藤 正樹, 藤村 健太, 早川 美和子, 加賀谷 斉, 向野 雅彦, 才藤 栄一
理学療法学, 43, 3, 255, 262, (公社)日本理学療法士協会, 2016年06月, ［査読有り］
日本語

The use of a holistic figure in gait analysis: a preliminary study on the effect of ankle-foot orthosis
Kannit Pongpipatpaiboon, Masahiko Mukaino, Kazuhiro Tsuchiyama, Kei Ohtsuka, Fumihiro Matsuda, Hiroki Tanikawa, Junya Yamada, Eiichi Saitoh
Jpn J Compr Rehabil Sci, 7, 80, 86, 一般社団法人 回復期リハビリテーション病棟協会, 2016年, ［査読有り］
英語, 研究論文（学術雑誌）,

Pongpipatpaiboon K, Mukaino M, Tsuchiyama K, Ohtsuka K, Matsuda F, Tanikawa H, Yamada J, Saitoh E. The use of a holistic figure in gait analysis: a preliminary study on the effect of ankle-foot orthosis. Jpn J Compr Rehabil Sci 2016; 7: 80-86.

Objective: To examine the practical usefulness of a simplified three-dimensional treadmill gait analysis with a Lissajous overview picture (LOP), a holistic figure of marker trajectories, to present the effect of ankle-foot orthoses (AFO) on hemiparetic gait.

Methods: Seven patients with hemiparesis who were able to walk without an orthosis or gait assistive device were included in this study. Patients were measured with a simplified three-dimensional treadmill gait analysis system as they walked with and without an orthosis in a rehabilitation center of a university medical center. Gait was analyzed using the LOP, and quantitative comparisons were made to evaluate the changes in joint angles and joint position displacements during the swing phase.

Results: Using the orthosis decreased ankle plantar flexion during the swing phase (p = 0.028) and significantly reduced compensatory patterns, including hip elevation, knee elevation, and circumduction (p = 0.028, 0.018, and 0.028, respectively).

Conclusions: The quantitative assessment by a simplified gait analysis system clarified the effect of AFO on reducing the compensatory movement in a hemiparetic gait. The use of LOP helps to understand the holistic effect of AFO and to analyze the individual patterns of gait disturbance.

非測定下肢の固定がHand-Held Dynamometerによる股関節外転筋力測定値に及ぼす影響　　　　　　　　　　　　　　　
谷川 広樹, 向野 雅彦, 松田 文浩, 稲垣 圭亮, 大塚 圭, 加賀谷 斉, 才藤 栄一, 金田 嘉清
Japanese Journal of Comprehensive Rehabilitation Science, 6(2015), 137, 142, (一社)回復期リハビリテーション病棟協会, 2016年01月
英語

Quantitative assessment of retropulsion of the hip, excessive hip external rotation, and excessive lateral shift of the trunk over the unaffected side in hemiplegia using three-dimensional treadmill gait analysis
Hiroki Tanikawa, Kei Ohtsuka, Masahiko Mukaino, Keisuke Inagaki, Fumihiro Matsuda, Toshio Teranishi, Yoshikiyo Kanada, Hitoshi Kagaya, Eiichi Saitoh
TOPICS IN STROKE REHABILITATION, 23, 5, 311, 317, 2016年, ［査読有り］
英語, 研究論文（学術雑誌）

当科におけるリンパ浮腫の治療成績
田矢理子, 加賀谷斉, 森志乃, 山田薫, 平野哲, 向野雅彦, 柴田斉子, 才藤栄一, 尾関恩, 小野木啓子
Jpn J Rehabil Med, 52, 12, 772, 773, (公社)日本リハビリテーション医学会, 2015年12月18日
日本語

3次元トレッドミル歩行分析を用いた装具の効果判定
布施郁子, 柴田斉子, 赤堀遼子, 平野哲, 向野雅彦, 青柳陽一郎, 加賀谷斉, 才藤栄一, 尾関恩
Jpn J Rehabil Med, 52, 12, 769, 769, (公社)日本リハビリテーション医学会, 2015年12月18日
日本語

Gait Exercise Assist Robot(GEAR) for hemiplegic gait reconstruction(和訳中)　　　　　　　　　　　　　　　
Saitoh Eiichi, Hirano Satoshi, Mukaino Masahiko, Ohtsuka Kei
臨床神経学, 55, Suppl., S60, S60, (一社)日本神経学会, 2015年12月
英語

片麻痺者の歩行における短下肢装具の効果 麻痺側遊脚時の機能障害と代償運動に着目して　　　　　　　　　　　　　　　
土山 和大, 松田 文浩, 向野 雅彦, 大塚 圭, 加賀谷 斉, 才藤 栄一
臨床歩行分析研究会定例会抄録集, 37回, 50, 51, 臨床歩行分析研究会, 2015年10月
日本語

BDNF Induced by Treadmill Training Contributes to the Suppression of Spasticity and Allodynia After Spinal Cord Injury via Upregulation of KCC2
Syoichi Tashiro, Munehisa Shinozaki, Masahiko Mukaino, Francois Renault-Mihara, Yoshiaki Toyama, Meigen Liu, Masaya Nakamura, Hideyuki Okano
NEUROREHABILITATION AND NEURAL REPAIR, 29, 7, 677, 689, 2015年08月, ［査読有り］
英語, 研究論文（学術雑誌）

嚥下造影検査施行後に嚥下内視鏡検査を用いてフォローアップした症例の検討
山田 薫, 小野木 啓子, 加賀谷 斉, 柴田 斉子, 青柳 陽一郎, 向野 雅彦, 布施 郁子, 山岸 宏江, 陳 輝, 才藤 栄一, 尾関 恩
The Japanese Journal of Rehabilitation Medicine, 52, 7, 439, 439, (公社)日本リハビリテーション医学会, 2015年07月
日本語

【進歩した神経内科疾患の実地診療●一般実地医家の活用と実践のために】 解明著しい神経内科疾患と手法の進歩 神経リハビリテーション　　　　　　　　　　　　　　　
向野 雅彦, 才藤 栄一
Medical Practice, 32, 6, 1009, 1011, (株)文光堂, 2015年06月
日本語

歩行分析の指標としての機能的脚長
向野雅彦, 松田文浩, 大塚圭, 加賀谷斉, 米田千賀子, 今井幸恵, 山村怜子, 田中ともみ, 河村美穂, 八谷カナン, 才藤栄一
Jpn J Rehabil Med, 52, S402, 2015年05月18日
日本語

バランス練習アシストを用いた前後外乱に対する運動学的検討　　　　　　　　　　　　　　　
石原 健, 才藤 栄一, 平野 哲, 向野 雅彦, 伊藤 慎英, 田辺 茂雄, 矢箆原 隆造, 加藤 翼, 布施 郁子, 前田 博士, 山中 学
The Japanese Journal of Rehabilitation Medicine, 52, Suppl., S403, S403, (公社)日本リハビリテーション医学会, 2015年05月
日本語

脳卒中片麻痺患者に対する歩行練習アシスト(GEAR)の効果　　　　　　　　　　　　　　　
平野 哲, 才藤 栄一, 園田 茂, 向野 雅彦, 田辺 茂雄, 大塚 圭, 加藤 正樹, 伊藤 慎英, 谷野 元一, 山田 純也, 井元 大介
The Japanese Journal of Rehabilitation Medicine, 52, Suppl., S402, S402, (公社)日本リハビリテーション医学会, 2015年05月
日本語

耳朶式脈拍計を用いた脈拍測定の信頼性　　　　　　　　　　　　　　　
向野 雅彦, 山田 純也, 加藤 正樹, 大塚 圭, 尾関 恩, 小野木 啓子, 才藤 栄一
The Japanese Journal of Rehabilitation Medicine, 52, Suppl., S313, S313, (公社)日本リハビリテーション医学会, 2015年05月
日本語

歩行分析機器の臨床活用 トレッドミル歩行分析
大塚 圭, 才藤 栄一, 向野 雅彦, 松田 文浩, 谷川 広樹
臨床歩行分析研究会誌, 2, 1, 11, 15, 臨床歩行分析研究会, 2015年05月
日本語

練習支援リハビリテーションロボット
才藤栄一, 平野哲, 田辺茂雄, 向野雅彦, 加賀谷斉
日本医学会総会総会会誌, 29th, 91, 2015年
日本語

脳卒中片麻痺患者の足部のクリアランスは機能的脚長の短縮量と股関節挙上量によって規定される
土山和大, 松田文浩, 向野雅彦, 大塚圭, 貝沼啓昭, 日高雅大, 加賀谷斉, 才藤栄一
日本臨床医療福祉学会プログラム・抄録集, 13th, 98, 2015年
日本語

超高齢社会の幕開けと今後の日本 臨床に役立つQ&A 1.超高齢社会における医療・福祉ロボットの動向について教えてください
向野雅彦, 才藤栄一, 平野哲
Geriatr Med, 53, 1, 63, 65, 2015年01月01日
日本語

Influence of contralateral lower limb stabilization on hip abductor muscle strength measured by Hand-Held Dynamometer
Tanikawa Hiroki, Mukaino Masahiko, Matsuda Fumihiro, Inagaki Keisuke, Ohtsuka Kei, Kagaya Hitoshi, Saitoh Eiichi, Kanada Yoshikiyo
Japanese Journal of Comprehensive Rehabilitation Science, 6, 0, 137, 142, 一般社団法人 回復期リハビリテーション病棟協会, 2015年, ［査読有り］
英語, Tanikawa H, Mukaino M, Matsuda F, Inagaki K, Ohtsuka K, Kagaya H, Saitoh E, Kanada Y. Influence of contralateral lower limb stabilization on hip abductor muscle strength measured by Hand-Held Dynamometer. Jpn J Compr Rehabil Sci 2015; 6: 137-142.Objective: To investigate the influence of contralateral lower limb function on hip abductor muscle strength using a hand-held dynamometer.Method: Thirty healthy subjects and fifty-nine hemiplegic patients participated in this study. Hip abductor muscle strength was measured in the supine position with or without stabilization of the contralateral lower limb (stabilizing vs. nonstabilizing method, respectively). Strength as measured using both methods was compared on each side for the lower limb and correlation coefficients for the two methods were calculated. In addition, correlation coefficients between measurements of strength using the two methods on both sides were calculated. In the hemiplegic patients, multiple regression analysis was performed using the strength on the affected side as the dependent variable, and the strength on the unaffected side and the degree of paralysis as independent variables.Results: Strength measured using the stabilizing method was significantly lower than when using the nonstabilizing method. The correlation between the strength on both sides was high in the healthy subjects despite contralateral lower limb stabilization, but low in the hemiplegic patients when using the nonstabilizing method. The strength on the affected side was strongly influenced by the unaffected lower limb function in measurements using the stabilizing method.Discussion: Measurements of hip abduction strength when using the stabilizing method are not an accurate reflection of the strength due to the influence of contralateral lower limb function.

左下四分盲に対するコンピュータ化視野訓練装置による短期効果
山岸 宏江, 平野 哲, 加賀谷 斉, 小野木 啓子, 柴田 斉子, 向野 雅彦, 石原 健, 才藤 栄一, 太田 喜久夫, 尾関 恩
The Japanese Journal of Rehabilitation Medicine, 51, 12, 811, 811, (公社)日本リハビリテーション医学会, 2014年12月
日本語

Functional recovery from chronic writer's cramp by brain-computer interface rehabilitation: a case report
Yasunari Hashimoto, Tetsuo Ota, Masahiko Mukaino, Meigen Liu, Junichi Ushiba
BMC NEUROSCIENCE, 15, 103, 2014年09月, ［査読有り］
英語, 研究論文（学術雑誌）

EFFICACY OF BRAIN-COMPUTER INTERFACE-DRIVEN NEUROMUSCULAR ELECTRICAL STIMULATION FOR CHRONIC PARESIS AFTER STROKE
Masahiko Mukaino, Takashi Ono, Keiichiro Shindo, Toshiyuki Fujiwara, Tetsuo Ota, Akio Kimura, Meigen Liu, Junichi Ushiba
JOURNAL OF REHABILITATION MEDICINE, 46, 4, 378, 382, 2014年04月, ［査読有り］
英語, 研究論文（学術雑誌）

Rewiring of regenerated axons by combining treadmill training with semaphorin3A inhibition
Liang Zhang, Shinjiro Kaneko, Kaoru Kikuchi, Akihiko Sano, Miho Maeda, Akiyoshi Kishino, Shinsuke Shibata, Masahiko Mukaino, Yoshiaki Toyama, Meigen Liu, Toru Kimura, Hideyuki Okano, Masaya Nakamura
MOLECULAR BRAIN, 7, 14, 2014年03月, ［査読有り］
英語, 研究論文（学術雑誌）

Brain-computer interface with somatosensory feedback improves functional recovery from severe hemiplegia due to chronic stroke.
Ono T, Shindo K, Kawashima K, Ota N, Ito M, Ota T, Mukaino M, Fujiwara T, Kimura A, Liu M, Ushiba J
Frontiers in neuroengineering, 7, 19, Frontiers Media SA, 2014年, ［査読有り］
研究論文（学術雑誌）

アトピー性脊髄炎による運動障害に対するリハビリテーション
吉田 直樹, 福岡 哲男, 今西 幸仁, 藤井 良憲, 向野 雅彦, 大田 哲生
The Japanese Journal of Rehabilitation Medicine, 50, 5, 339, 344, 2013年
日本語, 雑誌掲載版http://scpj.tulips.tsukuba.ac.jp/info/nii.html症例は35歳女性で、幼少期よりアトピー性皮膚炎があった。歩行時のふらつきが出現し、徐々に運動障害が進行して複数の病院を受診したが諸検査で異常は指摘されず、廃用症候群の診断で紹介受診した。両下肢はMMT 2で筋緊張は亢進し、ADL重介助の状態であり、精査のため神経内科紹介とした。頸部MRIで異常所見を認めなかったが、著明な血中IgE値の上昇と中枢運動伝導速度の低下よりアトピー性脊髄炎と診断された。ステロイドパルス療法と血漿交換療法を行い、リハビリテーション後に再来院した。基本動作およびADL向上を目的に訓練を開始し、歩行は右足部の内反傾向が強かったため右金属支柱付き短下肢装具を製作して立位・歩行練習を行った。両松葉杖で歩行可能となり5ヵ月後に自宅退院した。外来リハを継続し、A型ボツリヌス毒素製剤注射、バクロフェン内服で筋緊張は軽減したが、動揺性変化に備えて左金属支柱付き短下肢装具を製作し、使用を指導した。

Functional recovery in upper limb function in stroke survivors by using brain-computer interface A single case A-B-A-B design
Takashi Ono, Masahiko Mukaino, Junichi Ushiba
2013 35TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC), 2013, 265, 268, 2013年, ［査読有り］
英語, 研究論文（国際会議プロシーディングス）

Treatment effectiveness of brain-computer interface training for patients with focal hand dystonia: a double-case study
Yasunari Hashimoto, Tetsuo Ota, Masahiko Mukaino, Junichi Ushiba
2013 35TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC), 2013, 273, 276, 2013年, ［査読有り］
英語, 研究論文（国際会議プロシーディングス）

脳卒中回復期患者における尿意回復の予測因子
川上 途行, 向野 雅彦, 里宇 明元, 和田 彩子, 堀江 温子, 片平 真佐子, 安西 敦子, 大塚 友吉, 藤原 俊之, 辻 哲也, 長谷 公隆, 木村 彰男
The Japanese Journal of Rehabilitation Medicine, 49, Suppl., S197, S197, (公社)日本リハビリテーション医学会, 2012年05月
日本語

ニューロリハビリテーションとアンチエイジング　　　　　　　　　　　　　　　
向野 雅彦, 里宇明元
分子脳血管病, 11, 2, 169, 173, 2012年

Beneficial compaction of spinal cord lesion by migrating astrocytes through glycogen synthase kinase-3 inhibition
Francois Renault-Mihara, Hiroyuki Katoh, Takeshi Ikegami, Akio Iwanami, Masahiko Mukaino, Akimasa Yasuda, Satoshi Nori, Yo Mabuchi, Hirobumi Tada, Shinsuke Shibata, Ken Saito, Masayuki Matsushita, Kozo Kaibuchi, Seiji Okada, Yoshiaki Toyama, Masaya Nakamura, Hideyuki Okano
EMBO MOLECULAR MEDICINE, 3, 11, 682, 696, 2011年11月
英語, 研究論文（学術雑誌）

水中環境が歩行に及ぼす影響
宇内 景, 向野 雅彦, 田代 祥一, 當山 峰道, 新藤 恵一郎, 大田 哲生, 木村 彰男, 里宇 明元
The Japanese Journal of Rehabilitation Medicine, 48, Suppl., S235, S235, (公社)日本リハビリテーション医学会, 2011年10月
日本語

再生医療 臨床応用へ向けての現状と課題 リハビリテーションの果たす役割
向野 雅彦, 里宇明元, 木村 彰男
総合リハビリテーション, 39, 1, 7, 11, 医学書院, 2011年
日本語

各種難病の最新治療情報 脳卒中の後遺症の治療 リハビリテーションの現状と今後の展望
向野 雅彦, 木村 彰男
難病と在宅ケア, 17, 7, 49, 52, 日本プランニングセンター, 2011年
日本語

Novel Concept of Motor Functional Analysis for Spinal Cord Injury in Adult Mice
Munehisa Shinozaki, Yuichiro Takahashi, Masahiko Mukaino, Nobuhito Saito, Yoshiaki Toyama, Hideyuki Okano, Masaya Nakamura
JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, 2011, 2011年
英語, 研究論文（学術雑誌）

Beneficial compaction of spinal cord lesion by migrating astrocytes through glycogen synthase kinase-3 inhibition.
Renault-Mihara F, Katoh H, Ikegami T, Iwanami A, Mukaino M, Yasuda A, Nori S, Mabuchi Y, Tada H, Shibata S, Saito K, Matsushita M, Kaibuchi K, Okada S, Toyama Y, Nakamura M, Okano H
EMBO. Mol. Med., 2011年, ［査読有り］
英語, 研究論文（学術雑誌）

損傷脊髄の再生医療　　　　　　　　　　　　　　　
向野雅彦, 中村雅也
Journal of Clinical Rehabilitation, 20, 5, 456, 459, 2011年

Anti-IL-6-receptor antibody promotes repair of spinal cord injury by inducing microglia-dominant inflammation
Masahiko Mukaino, Masaya Nakamura, Osamu Yamada, Seiji Okada, Satoru Morikawa, Francois Renault-Mihara, Akio Iwanami, Takeshi Ikegami, Yoshiyuki Ohsugi, Osahiko Tsuji, Hiroyuki Katoh, Yumi Matsuzaki, Yoshiaki Toyama, Meigen Liu, Hideyuki Okano
EXPERIMENTAL NEUROLOGY, 224, 2, 403, 414, 2010年08月
英語, 研究論文（学術雑誌）

Anti-IL-6-receptor antibody promotes repair of spinal cord injury by inducing microglia-dominant inflammation
Mukaino, M, Nakamura, M, Yamada, O, Okada, S, Morikawa, S, Renault-Mihara, F, Iwanami, A, Ikegami, T, Ohsugi, Y, Tsuji, O, Katoh, H, Matsuzaki, Y, Toyama, Y, Liu, M, Okano, H
Exp Neurol, 224, 2, 403, 14, 2010年08月, ［国際誌］
英語, 研究論文（学術雑誌）, We previously reported the beneficial effect of administering an anti-mouse IL-6 receptor antibody (MR16-1) immediately after spinal cord injury (SCI). The purpose of our present study was to clarify the mechanism underlying how MR16-1 improves motor function after SCI. Quantitative analyses of inflammatory cells using flow cytometry, and immunohistochemistry with bone marrow-chimeric mice generated by transplanting genetically marked purified hematopoietic stem cells, revealed that MR16-1 dramatically switched the central player in the post-traumatic inflammation, from hematogenous macrophages to resident microglia. This change was accompanied by alterations in the expression of relevant cytokines within the injured spinal cord; the expression of recruiting chemokines including CCL2, CCL5, and CXCL10 was decreased, while that of Granulocyte/Macrophage-Colony Stimulating Factor (GM-CSF), a known mitogen for microglia, was increased. We also showed that the resident microglia expressed higher levels of phagocytic markers than the hematogenous macrophages. Consistent with these findings, we observed significantly decreased tissue damage and reduced levels of myelin debris and Nogo-A,

Therapeutic potential of appropriately evaluated safe-induced pluripotent stem cells for spinal cord injury
Osahiko Tsuji, Kyoko Miura, Yohei Okada, Kanehiro Fujiyoshi, Masahiko Mukaino, Narihito Nagoshi, Kazuya Kitamura, Gentaro Kumagai, Makoto Nishino, Shuta Tomisato, Hisanobu Higashi, Toshihiro Nagai, Hiroyuki Katoh, Kazuhisa Kohda, Yumi Matsuzaki, Michisuke Yuzaki, Eiji Ikeda, Yoshiaki Toyama, Masaya Nakamura, Shinya Yamanaka, Hideyuki Okano
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107, 28, 12704, 12709, 2010年07月
英語, 研究論文（学術雑誌）

脳卒中の転帰に影響する機能障害所見の検討
向野 雅彦, 赤星 和人, 小林 由紀子, 森 俊樹, 永田 雅章, 里宇 明元
The Japanese Journal of Rehabilitation Medicine, 47, Suppl., S278, S278, (公社)日本リハビリテーション医学会, 2010年04月
日本語

帯状疱疹による多発脳神経障害で嚥下障害を来たした症例のリハビリテーション
小林 由紀子, 赤星 和人, 田代 祥一, 向野 雅彦, 森 俊樹, 永田 雅章, 里宇 明元
The Japanese Journal of Rehabilitation Medicine, 47, Suppl., S283, S283, (公社)日本リハビリテーション医学会, 2010年04月
日本語

Roles of ES Cell-Derived Gliogenic Neural Stem/Progenitor Cells in Functional Recovery after Spinal Cord Injury
Gentaro Kumagai, Yohei Okada, Junichi Yamane, Narihito Nagoshi, Kazuya Kitamura, Masahiko Mukaino, Osahiko Tsuji, Kanehiro Fujiyoshi, Hiroyuki Katoh, Seiji Okada, Shinsuke Shibata, Yumi Matsuzaki, Satoshi Toh, Yoshiaki Toyama, Masaya Nakamura, Hideyuki Okano
PLOS ONE, 4, 11, e7706, e7706, 2009年11月
英語, 研究論文（学術雑誌）

脊髄損傷に対するES細胞由来神経幹細胞移植効果の違い
熊谷 玄太郎, 岡田 洋平, 山根 淳一, 名越 慈人, 北村 和也, 向野 雅彦, 辻 収彦, 藤 哲, 岡野 栄之, 戸山 芳昭, 中村 雅也
日本整形外科学会雑誌, 82, 8, S913, S913, (公社)日本整形外科学会, 2008年08月
日本語

Role of IL-6 in regulation of inflammation and stem cell differentiation in CNS trauma
Masahiko Mukaino, Masaya Nakamura, Seiji Okada, Yoshiaki Toyama, Meigen Liu, Hideyuki Okano
Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology, 31, 2, 93, 98, 2008年04月, ［査読有り］

Anti IL-6 antibody treatment reduces the infiltration of hematogenous macrophages into the injured spinal cord
Masahiko Mukaino, Masaya Nakamura, Osama Yamada, Seiji Okada, Satoru Morikawa, Yoshiyuki Osugi, Yumi Matsuzaki, Yoshiaki Toyama, Hideyuki Okano
NEUROSCIENCE RESEARCH, 61, S275, S275, 2008年
英語, 研究論文（学術雑誌）

脊髄損傷に対する抗IL-6受容体抗体の有効性の検討 損傷脊髄内の免疫反応に注目して　　　　　　　　　　　　　　　
向野 雅彦, 中村 雅也, 山田 理, 岡田 誠司, 山根 淳一, 大杉 義征, 松崎 有未, 戸山 芳昭, 里宇 明元, 岡野 栄之
Inflammation and Regeneration, 27, 4, 376, 376, (一社)日本炎症・再生医学会, 2007年07月
日本語

褥瘡に対して持続吸引療法を行った頸髄損傷患者の1例
山田 深, 川上 途行, 向野 雅彦, 田中 尚文, 長谷 公隆, 高橋 宣成, 鈴木 幹次郎, 松本 真以子, 里宇 明元, 千野 直一
リハビリテーション医学, 41, 2, 119, 120, (公社)日本リハビリテーション医学会, 2004年02月
日本語

脳出血後の易怒性に対して反復経頭蓋磁気刺激を実施した1例　　　　　　　　　　　　　　　
若林 央樹, 小川 真央, 梅森 秀, 遠山 晴一, 小金丸 聡子, 向野 雅彦, The Japanese Journal of Rehabilitation Medicine, 60, 秋季特別号, S390, S390, 2023年10月
(公社)日本リハビリテーション医学会, 日本語

リハビリテーション病棟脳卒中患者を対象としたウェアラブルデバイスを用いたFIMの将来予測
小笠原隆行, 和田義敬, 向野雅彦, 才藤栄一, 塚田信吾, 大高洋平, 山口真澄, 人工知能学会全国大会論文集(Web), 37th, 2023年

足内反に対するボツリヌス療法は歩容を変えるか?三次元トレッドミル歩行分析を用いた検討
伊藤翔太, 伊藤翔太, 谷川広樹, 加賀谷斉, 寺西利生, 向野雅彦, 藤村健太, 近藤輝, 近藤輝, 小関秀宙, 平野哲, 才藤栄一, 臨床歩行分析研究会定例会抄録集, 42nd (CD-ROM), 2021年

三次元動作解析を用いてボツリヌス療法の治療効果判定を行った1症例
蟹井貴也, 伊藤翔太, 伊藤翔太, 谷川広樹, 近藤輝, 小関秀宙, 向野雅彦, 加賀谷斉, 臨床歩行分析研究会定例会抄録集, 42nd (CD-ROM), 2021年

ICD-11に新たに導入された生活機能評価に関する補助セクション「V章」の活用及び普及に向けた研究 ICFの評点の採点用ガイドの作成,検証およびフィールドテストの実施
向野雅彦, 山田深, 大夛賀政昭, 出江紳一, ICD-11に新たに導入された生活機能評価に関する補助セレクション「V章」の活用及び普及に向けた研究 令和2年度 総括・分担研究報告書(Web), 2021年

脳卒中入院患者のリハビリテーション活動量向上のためのウェアラブルデバイスを用いた行動変容
小笠原隆行, 向野雅彦, 大高洋平, 山口真澄, 才藤栄一, 塚田信吾, 情報処理学会シンポジウムシリーズ(CD-ROM), 2021, 1, 2021年

脳卒中患者における日常の活動量と血清アルブミン値およびヘモグロビン値との相関の検討
和田義敬, 向野雅彦, 小笠原隆行, 松田文浩, 才藤栄一, 大高洋平, Japanese Journal of Rehabilitation Medicine, 58, Autumn, 2021年

脳血管疾患患者の退院時の歩行自立に関連する活動量関連パラメータの検討
松浦広昂, 松浦広昂, 向野雅彦, 鈴木卓弥, 小笠原隆行, 和田勇治, 青柳陽一郎, 青柳陽一郎, 大高洋平, Japanese Journal of Rehabilitation Medicine, 58, Autumn, 2021年

ウェアラブルデータと機械学習を用いた回復期リハビリ病棟脳卒中患者の機能指標(FIM)予測
小笠原隆行, 田中健太郎, 向野雅彦, 大高洋平, 山口真澄, 才藤栄一, 塚田信吾, 人工知能学会全国大会(Web), 35th, 2021年

ボツリヌス治療により歩行中の過度な肘屈曲と足内反が改善した1例
小関秀宙, 小関秀宙, 小関秀宙, 谷川広樹, 加賀谷斉, 近藤輝, 伊藤翔太, 寺西利生, 向野雅彦, 大高洋平, 才藤栄一, 日本ニューロリハビリテーション学会学術集会プログラム・抄録集, 11th, 2020年

介入肢位の違いが下腿三頭筋の痙縮に対する振動刺激効果に及ぼす影響
近藤輝, 谷川広樹, 向野雅彦, 伊藤翔太, 加藤正樹, 寺西利生, 大高洋平, 才藤栄一, 日本ニューロリハビリテーション学会学術集会プログラム・抄録集, 11th, 2020年

Smart clothingシステムを用いた加速度測定による活動量の定量
古澤章太郎, 向野雅彦, 小笠原隆行, 鈴木卓弥, 山田ゆりえ, 犬飼絢香, 松田文浩, 塚田信吾, 中島寛, 加藤正樹, 松浦広昂, 才藤栄一, 大高洋平, Japanese Journal of Rehabilitation Medicine, 57, Autumn, 2020年

リハビリテーション病棟における脳卒中リハビリ患者の運動機能と日常における運動強度との関連性
小笠原隆行, 松永賢一, 都甲浩芳, 向野雅彦, 電子情報通信学会大会講演論文集(CD-ROM), 2020, 2020年

hitoeシステムによる運動強度測定の妥当性の検証　　　　　　　　　　　　　　　
松浦 広昂, 向野 雅彦, 大高 洋平, 小笠原 隆行, 青嶋 保志, 鈴木 卓弥, 藤野 宏紀, 楠戸 正子, 才藤 栄一, The Japanese Journal of Rehabilitation Medicine, 56, 特別号, 2, 1, 2019年05月
(公社)日本リハビリテーション医学会, 日本語

関節抵抗トルク測定装置による速度依存的な痙縮評価
伊藤 翔太, 谷川 広樹, 向野 雅彦, 近藤 輝, 藤村 健太, 寺西 利生, 大塚 圭, 加藤 正樹, 加賀谷 斉, 才藤 栄一, The Japanese Journal of Rehabilitation Medicine, 56, 特別号, 2, P1K, 2019年05月
(公社)日本リハビリテーション医学会, 日本語

加齢が健常者歩行のToe clearanceとばらつきに与える影響　　　　　　　　　　　　　　　
村上 涼, 大塚 圭, 向野 雅彦, 山田 純也, 松田 文浩, 土山 和大, 才藤 栄一, 愛知県理学療法学会誌, 31, 特別号, 38, 38, 2019年03月
(NPO)愛知県理学療法学会, 日本語

Basic Neuroscience 神経生理 動物での脊髄障害と歩行　　　　　　　　　　　　　　　
向野 雅彦, Annual Review神経, 2019, 8, 14, 2019年03月
(株)中外医学社, 日本語

手すりの使用が片麻痺者のトレッドミル歩行に及ぼす影響
松田文浩, 大塚圭, 向野雅彦, 山田純也, 谷川広樹, 土山和大, 才藤栄一, 日本ニューロリハビリテーション学会学術集会プログラム・抄録集, 10th, 2019年

hitoeシステムを利用した回復期病棟入院患者の活動量の横断的調査
鈴木卓弥, 向野雅彦, 松浦広昂, 青嶋保志, 大河内由紀, 犬飼絢香, 服部恵実, 山田ゆりえ, 加藤正樹, 小笠原隆行, 才藤栄一, Japanese Journal of Rehabilitation Medicine, 56, Supplement, 2019年

回復期リハビリテーション病棟入院患者における運動強度とADL自立度の関係
青嶋保志, 向野雅彦, 松浦広昴, 松田文浩, 大河内由紀, 鈴木卓弥, 山田ゆりえ, 加藤正樹, 小笠原隆行, 才藤栄一, 東海北陸理学療法学術大会誌, 35th, 2019年

リハビリテーション患者のADL評価と入院中の生活活動の関連性
豊田新, 小笠原隆行, 佐藤里江子, 松永賢一, 向野雅彦, 電子情報通信学会大会講演論文集(CD-ROM), 2019, 2019年

リハビリテーション病棟における脳卒中リハビリ患者の運動機能と日常における活動状態との関連性
小笠原隆行, 佐藤里江子, 松永賢一, 向野雅彦, 電子情報通信学会大会講演論文集(CD-ROM), 2019, 2019年

リハビリ患者の活動状態モニタリング結果のフィードバック
佐藤里江子, 小笠原隆行, 豊田新, 松永賢一, 向野雅彦, 電子情報通信学会大会講演論文集(CD-ROM), 2019, 2019年

片麻痺患者に対する治療指向的トレッドミル歩行分析　　　　　　　　　　　　　　　
才藤 栄一, 向野 雅彦, 大塚 圭, The Japanese Journal of Rehabilitation Medicine, 55, 秋季特別号, S123, S123, 2018年10月
(公社)日本リハビリテーション医学会, 日本語

「心身機能・構造」「活動・参加」についての医師と作業療法士の連携 ICFの概論および臨床応用に向けた取り組み　　　　　　　　　　　　　　　
向野 雅彦, The Japanese Journal of Rehabilitation Medicine, 55, 秋季特別号, S235, S235, 2018年10月
(公社)日本リハビリテーション医学会, 日本語

ICF generic-30 setを用いた生活機能及び環境依存性の評価　　　　　　　　　　　　　　　
向野 雅彦, 千手 佑樹, 清水 康裕, 小池 知治, 米田 千賀子, 尾関 保則, 園田 茂, 才藤 栄一, The Japanese Journal of Rehabilitation Medicine, 55, 秋季特別号, S293, S293, 2018年10月
(公社)日本リハビリテーション医学会, 日本語

ELFプロジェクト Project of Exercise Log in FHUR当施設急性期病院と回復期病院における言語聴覚療法の比較と分析　　　　　　　　　　　　　　　
桑原 亜矢子, 稲本 陽子, 佐藤 百合子, 山路 千明, 加藤 正樹, 寺西 利生, 山田 将之, 向野 雅彦, 才藤 栄一, 言語聴覚研究, 15, 3, 240, 240, 2018年09月
(一社)日本言語聴覚士協会, 日本語

ロボットを使用した課題指向型リハビリテーション医療
近藤 和泉, 橋爪 美春, 加藤 健治, 向野 雅彦, Journal of Clinical Rehabilitation, 27, 6, 538, 542, 2018年06月
医歯薬出版(株), 日本語

リハビリテーション医療の臨床における歩行分析　　　　　　　　　　　　　　　
向野 雅彦, The Japanese Journal of Rehabilitation Medicine, 55, 特別号, S365, S365, 2018年05月
(公社)日本リハビリテーション医学会, 日本語

リハビリテーション医療における活動モニタリング　　　　　　　　　　　　　　　
向野 雅彦, The Japanese Journal of Rehabilitation Medicine, 55, 特別号, S467, S467, 2018年05月
(公社)日本リハビリテーション医学会, 日本語

国際生活機能分類を用いた生活機能の標準化指標作成の取り組み　　　　　　　　　　　　　　　
向野 雅彦, 才藤 栄一, 園田 茂, 岡崎 英人, 河村 美穂, 米田 千賀子, 尾関 保則, 小口 和代, 清水 康裕, 小池 知治, 戸田 芙美, 近藤 和泉, The Japanese Journal of Rehabilitation Medicine, 55, 特別号, 4, 4, 2018年05月
(公社)日本リハビリテーション医学会, 日本語

ICFリハビリテーションセットb項目における患者アンケート調査と医療者評価の比較　　　　　　　　　　　　　　　
千手 佑樹, 向野 雅彦, 渡邉 誠, 大河内 由紀, 水谷 公司, 才藤 栄一, 園田 茂, The Japanese Journal of Rehabilitation Medicine, 55, 特別号, 4, 4, 2018年05月
(公社)日本リハビリテーション医学会, 日本語

脳卒中片麻痺者における平地歩行とトレッドミル歩行の運動学的因子の比較　　　　　　　　　　　　　　　
山田 純也, 向野 雅彦, 大塚 圭, 松田 文浩, 谷川 広樹, 土山 和大, 日高 雅大, 伊東 慶, 安藤 大智, 王 裕香, 才藤 栄一, The Japanese Journal of Rehabilitation Medicine, 55, 特別号, 4, KP, 2018年05月
(公社)日本リハビリテーション医学会, 日本語

IoTの進展に向けた研究開発の取り組み ウェアラブル素材hitoeを応用したリハビリ支援の取り組み
小笠原隆行, 小笠原隆行, 松永賢一, 伊藤広樹, 大嶋尚一, 向野雅彦, NTT技術ジャーナル, 30, 7, 2018年

入院中の生活活動に着目したリハビリテーションアプローチの提案
豊田新, 小笠原隆行, 小笠原隆行, 松永賢一, 向野雅彦, 電子情報通信学会大会講演論文集(CD-ROM), 2018, 2018年

術前運動機能評価に基づく低侵襲人工股関節置換術(MIS‐THA)後の帰結予測
向野雅彦, 山田純也, 小桑隆, 大塚圭, 谷川広樹, 近藤環, 才藤栄一, 加賀谷斉, 森田充浩, 山田治基, 日本股関節学会学術集会プログラム・抄録集, 45th, 620, 2018年
日本語

3次元動作解析による低侵襲人工股関節全置換術(MIS‐THA)前後の運動学的因子の比較
小桑隆, 向野雅彦, 大塚圭, 谷川広樹, 山田純也, 近藤環, 才藤栄一, 加賀谷斉, 山田治基, 森田充浩, 日本股関節学会学術集会プログラム・抄録集, 45th, 618, 2018年
日本語

3次元動作解析による低侵襲人工股関節全置換術における術後早期の運動学的因子の比較
近藤環, 向野雅彦, 大塚圭, 谷川広樹, 山田純也, 小桑隆, 才藤栄一, 加賀谷斉, 山田治基, 森田充浩, 日本股関節学会学術集会プログラム・抄録集, 45th, 618, 2018年
日本語

医療の質の評価指標としてのICF評価セット(日本版)およびデータ収集ツールの作成 簡潔かつ直感的な説明文の日本語版作成
出江紳一, 才藤栄一, 向野雅彦, 医療の質の評価指標としてのICF評価セット(日本版)およびデータ収集ツールの作成 平成29年度 総括・分担研究報告書(Web), 201702004A0004 (WEB ONLY), 2018年
日本語

リハビリ、介護領域におけるロボット技術の応用の可能性 ロボティックスマートホーム開発の試み　　　　　　　　　　　　　　　
平野 哲, 才藤 栄一, 田辺 茂雄, 向野 雅彦, 加賀谷 斉, 大高 洋平, The Japanese Journal of Rehabilitation Medicine, 54, 秋季特別号, S83, S83, 2017年09月
(公社)日本リハビリテーション医学会, 日本語

ウェルウォークが片麻痺患者の歩行自立度回復に与える影響　　　　　　　　　　　　　　　
平野 哲, 才藤 栄一, 園田 茂, 加賀谷 斉, 角田 哲也, 布施 郁子, 波多野 和樹, 舟橋 怜佑, 向野 雅彦, 尾関 恩, 田辺 茂雄, 大塚 圭, The Japanese Journal of Rehabilitation Medicine, 54, 秋季特別号, S270, S270, 2017年09月
(公社)日本リハビリテーション医学会, 日本語

リハビリ、介護領域におけるロボット技術の応用の可能性 ロボティックスマートホーム開発の試み　　　　　　　　　　　　　　　
平野 哲, 才藤 栄一, 田辺 茂雄, 向野 雅彦, 加賀谷 斉, 大高 洋平, The Japanese Journal of Rehabilitation Medicine, 54, 秋季特別号, S83, S83, 2017年09月
(公社)日本リハビリテーション医学会, 日本語

国際生活機能分類を用いた生活機能の標準化指標作成の取り組み　　　　　　　　　　　　　　　
向野 雅彦, 才藤 栄一, 山田 深, 園田 茂, 水間 正澄, 出江 紳一, The Japanese Journal of Rehabilitation Medicine, 54, 秋季特別号, S265, S265, 2017年09月
(公社)日本リハビリテーション医学会, 日本語

国際生活機能分類を用いた生活機能の標準化指標作成の取り組み　　　　　　　　　　　　　　　
向野 雅彦, 才藤 栄一, 山田 深, 園田 茂, 水間 正澄, 出江 紳一, The Japanese Journal of Rehabilitation Medicine, 54, 秋季特別号, S265, S265, 2017年09月
(公社)日本リハビリテーション医学会, 日本語

【脳血管障害 診療のエッセンス】 リハビリテーション ロボット支援練習　　　　　　　　　　　　　　　
才藤 栄一, 平野 哲, 向野 雅彦, 日本医師会雑誌, 146, 特別1, S315, S316, 2017年06月
日本医師会, 日本語

【ニューロリハビリテーションの進歩】 療法と実際 バランス・歩行練習ロボット　　　　　　　　　　　　　　　
才藤 栄一, 平野 哲, 向野 雅彦, 加賀谷 斉, 園田 茂, Clinical Neuroscience, 35, 5, 576, 579, 2017年05月
(株)中外医学社, 日本語

リハビリテーション中の継時的な脈拍測定に基づく運動効率の評価　　　　　　　　　　　　　　　
松浦 広昂, 向野 雅彦, 平野 哲, 才藤 栄一, 加賀谷 斉, 角田 哲也, 大塚 圭, 加藤 正樹, 山田 純也, 青嶋 保志, The Japanese Journal of Rehabilitation Medicine, 54, 特別号, 1, 12, 2017年05月
(公社)日本リハビリテーション医学会, 日本語

ICFリハビリテーションセットの臨床使用における評点の信頼性に関わる検討
千手 佑樹, 向野 雅彦, 尾関 恩, 大河内 由紀, 水谷 公司, 才藤 栄一, 山田 深, 園田 茂, 出江 紳一, The Japanese Journal of Rehabilitation Medicine, 54, 特別号, 1, 5, 2017年05月
(公社)日本リハビリテーション医学会, 日本語

人工股関節全置換術前後の簡易な三次元歩行分析による歩容の比較
王裕香, 向野雅彦, 才藤栄一, 加賀谷斉, 加藤正樹, 森田充浩, 山田治基, 日本股関節学会学術集会プログラム・抄録集, 44th, 572, 2017年
日本語

大腿骨頸部骨折患者に対するバランス練習アシストの活用
井伊卓真, 平野哲, 才藤栄一, 園田茂, 加賀谷斉, 向野雅彦, 日本股関節学会学術集会プログラム・抄録集, 44th, 576, 2017年
日本語

簡易な三次元歩行分析を用いた日常臨床における歩容評価の実施可能性
向野雅彦, 王裕香, 加賀谷斉, 森田充浩, 加藤正樹, 山田治基, 才藤栄一, 日本股関節学会学術集会プログラム・抄録集, 44th, 604, 2017年
日本語

【医工、産学連携によるリハビリテーション】 ロボットを用いた歩行練習　　　　　　　　　　　　　　　
向野 雅彦, 平野 哲, 加賀谷 斉, MEDICAL REHABILITATION, 205, 29, 33, 2017年01月
(株)全日本病院出版会, 日本語

上肢ロボット
向野雅彦, 才藤栄一, 平野哲, 田辺茂雄, The Japanese Journal of Rehabilitation Medicine, 54, 2, 167, 168, 2017年, ［査読有り］

電気刺激に対するサイトカイン応答と唾液試料によるサイトカイン計測 がん悪液質患者への介入を想定した事前研究　　　　　　　　　　　　　　　
百田 貴洋, 加賀谷 斉, 山田 晃司, 向野 雅彦, 日本物理療法学会学術大会抄録集, 24回, 52, 52, 2016年10月
日本物理療法学会, 日本語

日常生活における上肢頻用動作に基づく客観的上肢機能評価法の検討　　　　　　　　　　　　　　　
太田 皓文, 向野 雅彦, 大河内 由紀, 保木本 のぞみ, 才藤 栄一, 日本作業療法学会抄録集, 50回, OA, 22, 2016年09月
(一社)日本作業療法士協会, 日本語

ICFの活用と研究に関する国際動向と展望 (特集 ICFコアセット)
向野 雅彦, 才藤 栄一, The Japanese journal of rehabilitation medicine = リハビリテーション医学, 53, 9, 690, 693, 2016年09月
日本リハビリテーション医学会 ; 2007-, 日本語

【ICFコアセット】 脳卒中リハビリテーションにおけるコアセットの活用
近藤 和泉, 伊藤 直樹, 向野 雅彦, The Japanese Journal of Rehabilitation Medicine, 53, 9, 681, 685, 2016年09月
(公社)日本リハビリテーション医学会, 日本語

脊髄障害性疼痛の治療とリハビリテーション 脊髄損傷に対する歩行訓練が,異常痛覚や痙縮に及ぼす影響とその分子的背景の解析,治療応用
田代祥一, 篠崎宗久, 向野雅彦, FRANCOIS Renault-Mihara, 戸山芳昭, 里宇明元, 中村雅也, 岡野栄之, Journal of Clinical Rehabilitation, 25, 6, 2016年

移動を支援するロボット
平野哲, 才藤栄一, 向野雅彦, 田辺茂雄, The Japanese Journal of Rehabilitation Medicine, 53, 12, 952, 954, 2016年
公益社団法人 日本リハビリテーション医学会, 日本語

リハビリテーションにおける活動機能構造連関 (第51回日本リハビリテーション医学会学術集会) -- (シンポジウム 活動機能構造連関 : 活動が変える)
向野 雅彦, The Japanese journal of rehabilitation medicine, 52, 2, 96, 100, 2015年02月
日本リハビリテーション医学会 ; 2007-, 日本語

ラット脊髄完全切断モデルに対するtreadmill訓練手法の検討と解析
張亮, 向野雅彦, 田代祥一, 中村雅也, 里宇明元, Japanese Journal of Rehabilitation Medicine, 52, 2015年

ラット脊髄完全損傷に対するsemaphorin3A阻害剤とtreadmill訓練の併用療法の検討
張亮, 向野雅彦, 田代祥一, 中村雅也, 里宇明元, Japanese Journal of Rehabilitation Medicine, 52, 2015年

脳卒中片麻痺患者の麻痺側遊脚相における足部のクリアランスを規定する因子の検討
松田文浩, 向野雅彦, 大塚圭, 土山和大, 貝沼啓昭, 日高雅大, 加賀谷斉, 才藤栄一, 日本ニューロリハビリテーション学会学術集会プログラム・抄録集, 6th, 43, 2015年
日本語

急性期病棟における療法士病棟専従の効果
平野 明日香, 加藤 正樹, 藤村 健太, 向野 雅彦, 加賀谷 斉, 才藤 栄一, 理学療法学Supplement, 2014, 0, 2015年
【はじめに，目的】当院は，高度な医療を開発・提供する特定機能病院であり，急性期のリハビリテーション（以下，リハ）に取り組んできたが，必要な患者全てにリハの提供が浸透していなかった。そこで2013年度から療法士を病棟に配置し，病棟医師，看護師と情報共有を密にすることで早期離床，早期ADL獲得など治療の効率化を図った。そして，疾患別リハ実施者においてリハ開始までの期間短縮，在院日数短縮，自宅復帰率向上など効果を得た。また，2014年度の診療報酬改定により急性期病棟におけるリハ専門職の配置に対する評価としてADL維持向上等体制加算が新設され，疾患別リハ算定者以外にも病棟療法士による病棟マネジメント業務を実践し，その効果が期待されるようになった。そこで今回，病棟に療法士を配置し，その前後で療法士病棟専従の効果を明確にするため比較検討したので報告する。【方法】当院呼吸器内科病棟（60床）において疾患別リハ実施者を対象とし，ADL維持向上等体制加算算定後の2014年4月1日より9月30日の間に当該病棟へ入棟した患者83例を専従群とした。また，療法士を病棟配置する前の2012年4月1日から9月30日の間に当該病棟へ入棟した患者44例を対照群とした。疾患分類は肺がん，COPD，肺炎，気胸等が多かった。療法士の病棟配置は理学療法士1名（臨床経験10年以上，認定理学療法士）を専従配置し，疾患別リハ実施者においてリハ部の患者データベースより後方視的に調査した。調査項目は在院日数，入院からリハ開始までの日数，リハ実施日数，FIM，転帰先とした。対照群と専従群で比較検討した。統計学的検討は有意水準5%とし，χ²検定，Mann-Whitney U検定，unpaired-t検定を用いた。また，疾患別リハ実施者に限らず，療法士病棟専従の効果を検証するために病棟医師，看護師にアンケート調査も行なった。取り組み内容として，入院患者に対する定期的なADL評価（入棟・退棟時を含む），ADL維持向上等を目的とした指導，転倒・転落の防止対策，患者・家族との情報共有，定期的なカンファレンスの参加などを通じて多職種恊働による治療の効率化に努めた。定期的なカンファレンスとして病棟看護師と朝・昼のカンファレンス，病棟医師・リハ科医師との週1回のカンファレンスなどを通じて治療方針の統一，早期退院支援，廃用予防，ADL向上を多職種で行なった。カンファレンス以外にも適宜必要な情報共有を行なった。【結果】病棟全体の患者のうちリハ実施している患者の割合は対照群20.3%，専従群50.4%と有意に増加した。疾患別リハ実施者において，在院日数は対照群44.8±34.8日，専従群28.6±18.7日，入院からリハ開始までの日数は対照群14.3±15.5日，専従群5.0±4.3日と有意に短縮した。自宅復帰率は対照群77.3%，専従群80.7%であった。リハ実施日数は対照群30.5±24.2日，専従群23.6±16.2日であった。リハ開始時FIM総合計は対照群83.5±27.8点，専従群80.3±30.4点，リハ終了時FIM総合計は対照群96.7±26.4点，専従群96.0±29.4点，FIM効率は対照群0.49±0.66，専従群0.63±0.83であった。また，病棟全体の患者において，ADL維持向上等体制加算算定後はADL低下率が2.1%，褥創発生率0%であった。そして，病棟医師，看護師対象のアンケート調査から，療法士の病棟専従によって情報共有がし易くなった，在宅へ向けた指導がし易くなった，廃用による体力低下の防止ができた，ADL能力の回復が早くなった，リハ内容が把握し易くなったなどの意見が多数みられた。【考察】取り組みによって新規入院患者の把握による早期リハの開始，ADL維持向上の実施，状態変化者の把握による患者の安全管理の実施，状態にあわせて早期離床，早期退院，自宅復帰推進等ができたと考えられた。以上から療法士の病棟専従により，病棟医師，看護師との効率的連携が生まれ，疾患別リハ実施割合の向上，在院日数短縮，自宅復帰率の向上などに繋がったと考えられた。【理学療法学研究としての意義】2014年度の診療報酬改定によりADL維持向上等体制加算が新設され，今までの疾患別リハのみならず，病棟マネジメント業務まで幅広く行なうようになった。今回の取り組みを通じて，リハに対する認知度が向上し，入院早期からリハ開始，在院日数短縮などの効果がみられた。さらに，現時点ではADL維持向上等体制加算を実施するための取り組みに対する細かな規定はないため，今回の研究で一つの指標を示すことができたと考えられる。引き続き急性期リハの効果，実際の取り組み内容の指標が明確になるように検討していく。, 公益社団法人 日本理学療法士協会, 日本語

脊髄損傷後の運動負荷が誘導するBDNFによるKCC2発現制御とその分子的背景
田代祥一, 篠崎宗久, 向野雅彦, 岡野栄之, 戸山芳昭, 里宇明元, 中村雅也, Journal of Spine Research, 5, 3, 2014年

脊髄損傷後の運動負荷が誘導するBDNFによるKCC2発現制御とその分子的背景
田代祥一, 篠崎宗久, 向野雅彦, 中村雅也, 里宇明元, Japanese Journal of Rehabilitation Medicine, 51, 2014年

症例から学ぶ臨床神経生理学(第3回)末梢神経障害 : 下肢
大田 哲生, 向野 雅彦, 総合リハビリテーション, 41, 3, 263, 268, 2013年03月
医学書院, 日本語

損傷後早期の運動負荷によるBDNFの上昇は,KCC2発現増加を介して長期的な疼痛と痙性の抑制に寄与する
田代祥一, 田代祥一, 篠崎宗久, 向野雅彦, 里宇明元, 中村雅也, Japanese Journal of Rehabilitation Medicine, 50, 2013年

再生医学と理学療法の展望
向野 雅彦, 理学療法学 = The Journal of Japanese Physical Therapy Association, 39, 8, 499, 502, 2012年12月20日
公益社団法人日本理学療法士協会, 日本語

K-067 再生医学と理学療法の展望(先端科学と理学療法,特別講演II,プロフェッション!新たなるステージへ,第47回日本理学療法学術大会)
向野 雅彦, 理学療法学, 39, 1, 208, 208, 2012年05月25日
公益社団法人日本理学療法士協会, 日本語

初発脳梗塞患者の離床時期 Branch Atheromatous Disease症例に着目して
渡邉 恵莉, 川上 途行, 藤原 俊之, 小原 朋子, 笠島 悠子, 富岡 曜平, 前島 早代, 宮田 知恵子, 向野 雅彦, 石川 愛子, 松本 真以子, 大高 洋平, 興津 太郎, 辻 哲也, 長谷 公隆, 木村 彰男, 里宇 明元, The Japanese Journal of Rehabilitation Medicine, 49, Suppl., S168, S168, 2012年05月
(公社)日本リハビリテーション医学会, 日本語

油圧制動足継手付き短下肢装具による底屈制動の違いが片麻痺歩行に及ぼす影響
富岡 曜平, 長谷 公隆, 渡邉 恵莉, 前島 早代, 小原 朋子, 向野 雅彦, 川上 途行, 笠島 悠子, 松本 真以子, 大高 洋平, 藤原 俊之, 辻 哲也, 木村 彰男, 里宇 明元, The Japanese Journal of Rehabilitation Medicine, 49, Suppl., S262, S262, 2012年05月
(公社)日本リハビリテーション医学会, 日本語

胸部食道癌根治術後の嚥下障害 背景因子、術式、(声帯麻痺反回神経麻痺)と嚥下評価、術後経過との関係
小原 朋子, 松本 真以子, 辻 哲也, 長田 麻衣子, 富岡 曜平, 渡邉 恵莉, 前島 早代, 川上 途行, 宮田 知恵子, 向野 雅彦, 笠島 悠子, 石川 愛子, 大高 洋平, 興津 太郎, 藤原 俊之, 長谷 公隆, 木村 彰男, 里宇 明元, The Japanese Journal of Rehabilitation Medicine, 49, Suppl., S302, S302, 2012年05月
(公社)日本リハビリテーション医学会, 日本語

誤嚥性肺炎の発生率と咳嗽力との関係 Peak cough flowと嚥下機能評価
前島 早代, 川上 途行, 小原 朋子, 渡邉 恵莉, 富岡 曜平, 宮田 知恵子, 向野 雅彦, 笠島 悠子, 石川 愛子, 松本 真以子, 大高 洋平, 藤原 俊之, 辻 哲也, 長谷 公隆, 木村 彰男, 里宇 明元, The Japanese Journal of Rehabilitation Medicine, 49, Suppl., S410, S410, 2012年05月
(公社)日本リハビリテーション医学会, 日本語

トイレ関連動作の自立をゴールとした機能障害チェックリストの作成
向野雅彦, 伊海友雪, 吉田亜友美, 田代祥一, 宇内景, 當山峰道, 新藤恵一郎, 大田哲生, 木村彰男, 里宇明元, Japanese Journal of Rehabilitation Medicine, 48, 2011年

脳卒中における高次脳機能障害への白質損傷の関わり
向野雅彦, 猪瀬学, 小野峻史, 宇内景, 田代祥一, 當山峰道, 新藤恵一郎, 大田哲生, 木村彰男, 里宇明元, Japanese Journal of Rehabilitation Medicine, 48, 2011年

Beneficial compaction of spinal cord lesion by migrating astrocytes through Glycogen Synthase Kinase-3 inhibition
Francois Renault-Mihara, Hiroyuki Katoh, Takeshi Ikegami, Akio Iwanami, Masahiko Mukaino, Hirobumi Tada, Akimasa Yasuda, Satoshi Nori, Shinsuke Shibata, Ken Saito, Masayuki Matsushita, Kozo Kaibuchi, Seiji Okada, Yoshiaki Toyama, Masaya Nakamura, Hideyuki Okano, NEUROSCIENCE RESEARCH, 71, E59, E59, 2011年
英語, 研究発表ペーパー・要旨（国際会議）

Role and mechanisms of reactive astrocytes? Migration after spinal cord injury
Francois Renault-Mihara, Masahiko Mukaino, Munehisa Shinozaki, Yoshiaki Toyama, Masaya Nakamura, Hideyuki Okano, NEUROSCIENCE RESEARCH, 68, E242, E243, 2010年
英語, 研究発表ペーパー・要旨（国際会議）

Combining extensive treadmill training with a selective semaphorin3A inhibitor treatment enhances locomotor functional recovery by wiring regenerated axons in adult spinal cord-transected rats
Liang Zhang, Shinjiro Kaneko, Akihiko Sano, Miho Maeda, Akiyoshi Kishino, Masahiko Mukaino, Yoshiaki Toyama, Meigen Liu, Masaya Nakamura, Hideyuki Okano, NEUROSCIENCE RESEARCH, 68, E259, E260, 2010年
英語, 研究発表ペーパー・要旨（国際会議）

ラット脊髄損傷モデルに対する荷重下歩行訓練の効果の検討
向野 雅彦, 中村 雅也, 戸山 芳昭, 岡野 栄之, 里宇 明元, 末梢神経 = Peripheral nerve, 20, 2, 266, 267, 2009年12月01日
日本語

c-Mycを除いたマウス3因子iPS細胞由来神経幹細胞を用いた脊髄損傷治療
辻 収彦, 三浦 恭子, 藤吉 兼浩, 向野 雅彦, 名越 慈人, 熊谷 玄太郎, 山中 伸弥, 岡野 栄之, 戸山 芳昭, 中村 雅也, 日本整形外科学会雑誌, 83, 8, S1068, S1068, 2009年08月
(公社)日本整形外科学会, 日本語

脊髄損傷に対するiPS細胞由来神経幹細胞移植 機能回復メカニズムの解析
辻 収彦, 三浦 恭子, 藤吉 兼浩, 名越 慈人, 北村 和也, 向野 雅彦, 熊谷 玄太郎, 千葉 一裕, 山中 伸弥, 岡野 栄之, 戸山 芳昭, 中村 雅也, 日本脊椎脊髄病学会雑誌, 20, 2, 461, 461, 2009年03月
(一社)日本脊椎脊髄病学会, 日本語

再生医学 (特集 脊髄損傷リハビリテーション--現状・課題・展望)
向野 雅彦, 総合リハビリテ-ション, 36, 10, 929, 932, 2008年10月
医学書院, 日本語

The role of cytokine signaling in pathophysiology for spinal cord injury
Okada Seiji, Nakamura Masaya, Renault-Mihara Francois, MUKAINO Masahiko, SAIWAI Hirokazu, TOYAMA Yoshiaki, IWAMOTO Yukihide, OKANO Hideyuki, 炎症・再生 : 日本炎症・再生医学会雑誌 = Inflammation and regeneration, 28, 5, 440, 446, 2008年09月25日
日本炎症・再生医学会, 英語

顕微鏡的MRIによるコモンマーモセット脊髄損傷の病態解析—q‐space MR imagingを用いて—
藤吉兼浩, 疋島啓吾, 北村和也, 岩波明生, 辻収彦, 向野雅彦, 加藤裕幸, 百島祐貴, 岡野栄之, 戸山芳昭, 中村雅也, 日本整形外科学会雑誌, 82, 8, S936, S936, 2008年08月25日
(公社)日本整形外科学会, 日本語

脊髄損傷に対する人工多能性幹細胞由来神経幹細胞移植の検討
辻 収彦, 三浦 恭子, 藤吉 兼弘, 北村 和也, 名越 慈人, 向野 雅彦, 熊谷 玄太郎, 山中 伸弥, 岡野 栄之, 戸山 芳昭, 中村 雅也, 日本整形外科学会雑誌, 82, 8, S912, S912, 2008年08月
(公社)日本整形外科学会, 日本語

Lecture 拡散テンソルトラクトグラフィー
藤吉兼浩, 中村雅也, 山田雅之, 山田雅之, 疋島啓吾, 疋島啓吾, 北村和也, 辻収彦, 名越慈人, 向野雅彦, 百島祐貴, 加藤裕幸, 石井賢, 松本守雄, 千葉一裕, 岡野栄之, 戸山芳昭, 臨床整形外科, 43, 7, 692-699, 699, 2008年07月25日
(株)医学書院, 日本語

1-4-11 ラット脊髄損傷モデルにおける運動負荷訓練が機能回復及び痙性に与える効果(脊髄損傷(症例(2)),口演,一般演題,リハビリテーション医学の進歩"評価から治療介入へ",第45回日本リハビリテーション医学会学術集会)
向野 雅彦, 中村 雅也, 戸山 芳昭, 岡野 栄之, 里宇 明元, リハビリテーション医学 : 日本リハビリテーション医学会誌, 45, 0, S153, 2008年05月18日
社団法人日本リハビリテーション医学会, 日本語

拡散テンソルtractographyによる損傷末梢神経の描出—組織変化と拡散異方性—
高木岳彦, 中村雅也, 山田雅之, 疋島啓吾, 藤吉兼浩, 向野雅彦, 岡野James洋尚, 百島祐貴, 戸山芳昭, 岡野栄之, 日本磁気共鳴医学会雑誌, 28, 1, 45, 45, 2008年01月15日
(一社)日本磁気共鳴医学会, 日本語

Comparison between ES cell-derived neurogenic and gliogenic neurospheres as a source of transplantation for spinal cord injury
Gentaro Kumagai, Masaya Nakamura, Yohei Okada, Junichi Yamane, Narihito Nagoshi, Kazuya Kitamura, Osahiko Tsuji, Masahiko Mukaino, Satoshi Toh, Yoshiaki Toyama, Hideyuki Okano, NEUROSCIENCE RESEARCH, 61, S43, S43, 2008年
英語, 研究発表ペーパー・要旨（国際会議）

Cell therapy for spinal cord injury by neural stem/progenitor cells derived from induced pluripotent stem cells
Osahiko Tsuji, Kyoko Miura, Masaya Nakamura, Narihito Nagoshi, Kazuya Kitamura, Kanehiro Fujiyoshi, Masahiko Mukaino, Gentaro Kumagai, Hiroyuki Katoh, Okada Yohei, Shinya Yamanaka, Yoshiaki Toyama, Hideyuki Okano, NEUROSCIENCE RESEARCH, 61, S69, S69, 2008年
英語, 研究発表ペーパー・要旨（国際会議）

拡散テンソル法を用いた末梢神経線維のtractography—ex vivoモデルでの検討—
高木岳彦, 中村雅也, 山田雅之, 疋島啓吾, 藤吉兼浩, 向野雅彦, 岡野James洋尚, 百島祐貴, 岡野栄之, 戸山芳昭, 日本末梢神経学会学術集会プログラム・抄録, 18th, 2, 60, 240, 2007年12月
日本末梢神経学会, 日本語

拡散テンソル法を用いた末梢神経線維の tractography : ex vivo モデルでの検討
高木 岳彦, 中村 雅也, 山田 雅之, 疋島 啓吾, 百島 祐貴, 藤吉 兼浩, 向野 雅彦, 岡野 James 洋尚, 岡野 栄之, 戸山 芳昭, 末梢神経 = Peripheral nerve, 18, 2, 239, 240, 2007年12月01日
日本語

脊髄損傷
向野雅彦, IL-6 Bench to Bedside, 83, 88, 2007年
メディカルレビュー社

講座 再生医学とリハビリテーション(3)再生医学とリハビリテーション
植村 修, 向野 雅彦, 里宇 明元, 総合リハビリテ-ション, 33, 12, 1125, 1131, 2005年12月
医学書院, 日本語

再生医学とリハビリテーション(第42回 日本リハビリテーション医学会 学術集会)
向野 雅彦, 里宇 明元, 岡野 栄之, リハビリテーション医学 : 日本リハビリテーション医学会誌, 42, 10, 702, 707, 2005年10月18日
社団法人日本リハビリテーション医学会, 日本語

運動単位の同期発射 前脛骨筋とヒラメ筋の違い　　　　　　　　　　　　　　　
正門 由久, 山田 理絵, 牛場 潤一, 大田 哲生, 水野 勝広, 補永 薫, 向野 雅彦, 木村 彰男, 富田 豊, リハビリテーション医学, 41, Suppl., S222, S222, 2004年05月
(公社)日本リハビリテーション医学会, 日本語

健常者における運動イメージ時の運動誘発電位の検討 異なる種類の運動イメージが及ぼす影響　　　　　　　　　　　　　　　
大田 哲生, 村岡 慶裕, 辻 哲也, 水野 勝広, 補永 薫, 向野 雅彦, 正門 由久, 木村 彰男, リハビリテーション医学, 41, Suppl., S215, S215, 2004年05月
(公社)日本リハビリテーション医学会, 日本語

マスター脳卒中学 : 最前線医療の現場からリハビリテーションまで
田川, 皓一, 橋本, 洋一郎, 稲富, 雄一郎, 脳卒中リハビリテーションの基本的な考え方
西村書店, 2019年02月, 9784890134939, xx, 587p, 日本語

現代リハビリテーション医学
椿原, 彰夫, 才藤, 栄一, 出江, 紳一, 道免, 和久, 千野, 直一, 再生医療とリハビリテーション医学
金原出版, 2017年07月, 9784307750523, xvi, 459p, 日本語

義肢装具のチェックポイント第８版　　　　　　　　　　　　　　　
伊藤 利之, 赤居 正美, 車椅子
医学書院, 2014年

炎症・再生医学事典　　　　　　　　　　　　　　　
松島綱治, 西脇徹, Ⅱ再生医学・B体性幹細胞と組織修復・1脳神経
朝倉書店, 2009年

IL-6 Bench to Bedside
西本, 憲弘, 平野, 俊夫, 脊髄損傷
メディカルレビュー社, 2007年04月, 9784779200984, 145p, 日本語

リハビリテーション医学における活動モニタリングの意義　　　　　　　　　　　　　　　
向野 雅彦
第58回日本リハビリテーション医学会学術集会, 口頭発表（招待・特別）
2021年06月10日 - 2021年06月13日, ［招待講演］

三次元歩行分析によるリハビリテーション効果の理解と臨床における意思決定への活用　　　　　　　　　　　　　　　
向野 雅彦
第57回日本リハビリテーション医学会学術集会, 口頭発表（招待・特別）
2020年08月19日 - 2020年08月22日

ICFの基本と臨床応用の取り組み　　　　　　　　　　　　　　　
向野 雅彦
第56回日本リハビリテーション医学会学術集会, 口頭発表（招待・特別）
2019年06月12日 - 2019年06月16日, ［招待講演］

ICDとICFの一体としての統計への導入の可能性　　　　　　　　　　　　　　　
向野 雅彦
日・WHOフォーラム2018, 2018年11月18日, 口頭発表（招待・特別）
2018年11月18日 - 2018年11月18日, ［招待講演］

三次元歩行分析による義肢装具の効果の理解　　　　　　　　　　　　　　　
向野 雅彦
第34回日本義肢装具学会学術大会, 口頭発表（招待・特別）
2018年11月10日 - 2018年11月11日, ［招待講演］

リハビリテーション医療における活動モニタリング　　　　　　　　　　　　　　　
向野 雅彦
第55回日本リハビリテーション医学会学術集会, 公開講演，セミナー，チュートリアル，講習，講義等
2018年06月28日 - 2018年07月01日, ［招待講演］

リハビリテーション医療の臨床における歩行分析　　　　　　　　　　　　　　　
向野 雅彦
第55回日本リハビリテーション医学会学術集会, 口頭発表（招待・特別）
2018年06月28日 - 2018年07月01日, ［招待講演］

ウェルウォークが片麻痺患者の歩行自立度回復に与える影響　　　　　　　　　　　　　　　
平野 哲, 才藤 栄一, 園田 茂, 加賀谷 斉, 角田 哲也, 布施 郁子, 波多野 和樹, 舟橋 怜佑, 向野 雅彦, 尾関 恩, 田辺 茂雄, 大塚 圭
The Japanese Journal of Rehabilitation Medicine, 2017年09月, 日本語

国際生活機能分類を用いた生活機能の標準化指標作成の取り組み　　　　　　　　　　　　　　　
向野 雅彦, 才藤 栄一, 山田 深, 園田 茂, 水間 正澄, 出江 紳一
The Japanese Journal of Rehabilitation Medicine, 2017年09月, 日本語

リハビリ、介護領域におけるロボット技術の応用の可能性 ロボティックスマートホーム開発の試み　　　　　　　　　　　　　　　
平野 哲, 才藤 栄一, 田辺 茂雄, 向野 雅彦, 加賀谷 斉, 大高 洋平
The Japanese Journal of Rehabilitation Medicine, 2017年09月, 日本語

リハビリテーション中の継時的な脈拍測定に基づく運動効率の評価　　　　　　　　　　　　　　　
松浦 広昂, 向野 雅彦, 平野 哲, 才藤 栄一, 加賀谷 斉, 角田 哲也, 大塚 圭, 加藤 正樹, 山田 純也, 青嶋 保志
The Japanese Journal of Rehabilitation Medicine, 2017年05月, 日本語

ICFリハビリテーションセットの臨床使用における評点の信頼性に関わる検討　　　　　　　　　　　　　　　
千手 佑樹, 向野 雅彦, 尾関 恩, 大河内 由紀, 水谷 公司, 才藤 栄一, 山田 深, 園田 茂, 出江 紳一
The Japanese Journal of Rehabilitation Medicine, 2017年05月, 日本語

Japanese experience in the development of national rehabilitation quality management systems　　　　　　　　　　　　　　　
Masahiko Mukaino
10th International Society of Physical and Rehabilitation Medicine World Congress, 2016年06月, 英語
Kuala lumpur, Malaysia, ［招待講演］

Development of a clinical tool for measuring dynamic balance function: A proof-of-concept study　　　　　　　　　　　　　　　
Masahiko Mukaino
5th Asia-Oceanian Conference of Physical and Rehabilitation Medicine, 2016年02月, 英語
Cebu, Philippines

ICFの概念と実際　　　　　　　　　　　　　　　
向野雅彦
第53回日本リハビリテーション医学会, 2016年
京都府京都市

The effect of instruction focusing on single versus multi movement parameters on upper limb exercise training,　　　　　　　　　　　　　　　
Masahiko Mukaino
9th International Society of Physical and Rehabilitation Medicine World Congress, 2015年05月, 英語
Berlin, Germany, ［招待講演］

急性期病棟における療法士病棟専従の効果 ADL維持向上等体制加算の開始前後の比較　　　　　　　　　　　　　　　
平野 明日香, 加藤 正樹, 藤村 健太, 向野 雅彦, 加賀谷 斉, 才藤 栄一
理学療法学, 2015年04月, 日本語

耳朶式脈拍計を用いた脈拍測定の信頼性.　　　　　　　　　　　　　　　
向野雅彦, 山田純也, 加藤正樹, 大塚 圭, 尾関, 恩, 小野木啓子, 才藤栄一
第52回日本リハビリテーション医学会, 2015年
新潟県新潟市

歩行分析の指標としての機能的脚長　　　　　　　　　　　　　　　
向野雅彦, 松田文浩, 大塚 圭, 加賀谷斉, 米田千賀子, 今井幸恵, 山村怜子, 田中ともみ, 河村美穂, 八谷カナン 才藤栄一
第52回日本リハビリテーション医学会, 2015年
新潟県新潟市

歩行の神経生理と治療戦略 歩行訓練と脊髄内の構造変化　　　　　　　　　　　　　　　
向野 雅彦
第42回日本臨床神経生理学会学術大会, 2012年
東京

The benefits of early intervention of training for functional recovery after spinal cord injury　　　　　　　　　　　　　　　
Masahiko Mukaino, Osahiko Tsuji, Kanehiro Fujiyoshi, Tetsuo Ota, Meigen Liu, Yoshiaki Toyama, Hideyuki Okano, Masaya Nakamura
Neuroscience 2012, 2012年
New Orleans

脳卒中における高次脳機能障害への白質損傷の関わり　　　　　　　　　　　　　　　
向野 雅彦, 猪瀬 学, 小野 峻史, 宇内 景, 田代 祥一, 當山 峰道, 新藤 恵一郎, 大田 哲生, 木村 彰男, 里宇 明元
第48回日本リハビリテーション医学会学術集会, 2011年
千葉

トイレ関連動作の自立をゴールとした機能障害チェックリストの作成　　　　　　　　　　　　　　　
向野 雅彦, 伊海 友雪, 吉田 亜友美, 田代 祥一, 宇内 景, 當山 峰道, 新藤 恵一郎, 大田 哲生, 木村 彰男, 里宇 明元
第48回日本リハビリテーション医学会学術集会, 2011年
千葉

ブレイン・マシーン・インターフェースを用いた神経筋電気刺激(BMI-NMES)の有効性の検討　　　　　　　　　　　　　　　
向野 雅彦, 小野 峻史, 新藤 恵一郎, 當山 峰道, 宇内 景, 大田 哲生, 牛場 潤一, 木村 彰男, 里宇 明元
第41回日本臨床神経生理学会学術大会, 2011年
静岡

脳卒中の転帰に影響する機能障害所見の検討　　　　　　　　　　　　　　　
向野 雅彦, 赤星 和人, 小林 由紀子, 森 俊樹, 永田 雅章, 里宇 明元
第47回日本リハビリテーション医学会学術集会, 2010年
鹿児島

ラット脊髄損傷モデルに対する荷重下歩行訓練の効果の検討　　　　　　　　　　　　　　　
向野 雅彦, 中村 雅也, 戸山 芳昭, 岡野 栄之, 里宇 明元
第20回日本末梢神経学会学術集会, 2009年
埼玉